Inclusion Criteria:  living-donor kidney transplantation; eGFR level > 45ml/min/1.73m2 at discharge; 18<Age<65 years; receiving standard triad immunosuppressive regimen.  Exclusion Criteria:  previous therapy with metformin or SGLT 2 over the previous 3 months; alanine aminotransferase (ALT) or aspartate aminotransferase (AST) > 2.5 or more of upper limit of normal; Combined with HBV/HCV/HIV infection in the donor or recipient; Malignancy history in the donor and recipient; 6) organ transplant history in the recipient.