Inclusion Criteria:  Male/Female subject must be 18 years of age or over. Affected by periodontitis, with at least 20 sites with PPD>4mm and have at least 20 teeth (excluding wisdom teeth). Have voluntarily signed the informed consent.  Exclusion Criteria:  Presence of any systemic diseases (e.g., diabetes mellitus or cardiovascular, kidney, liver or lung disease). Pregnant or breastfeeding. Regular use of analgesic or antibiotics within 1 month before entering the study. Have untreated gross carious lesions and/or insufficient restorations. Allergic to any ingredient in the products provided within the trial as determined by the dental/medical professional monitoring the study. Concurrent participation in other clinical studies.