Inclusion Criteria:  1. Pathological confirmed melanoma 2. Advanced stage confirmed by radiological examination 3. Untreated 4. ECOG PS 0-1 6. Good organ function 7. No other severe diseases such as autoimmune disease, organ transplant, chronic infection.  8. Other tumor disease.  Exclusion Criteria:  Symptomatic brain metastases Active infection Active HBV or HCV infection HIV infection Autoimmune disease Sensitive to drug or ingredients Severe mental disorders Sever disfunction of heart, liver and kidney