Inclusion Criteria:  Age greater than or equal to 18 years of age Able to sign consent Planned Endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) for polyps within the upper and lower GI tract Polyp size greater than 25mm  Exclusion Criteria:  Pregnant patients Prisoners Unable to sign consent Polyp size less than or equal to 24mm