Inclusion Criteria:  Chronic and recurrent ENL cases of leprosy regardless of age, sex and treatment status with MDT Patients not responded with paracetamol, clofazimine, pentoxifylline, colchicine, methotrexate, azathioprine, TNF inhibitors etc., Patients who can give valid consent. Willing for monthly follow-up visits for at least 3 months.  Exclusion Criteria:  Pregnant and lactating mothers Severe renal dysfunction Patients with HIV, Hepatitis B and Hepatitis C Inability to come for monthly follow up visits for 6 months Those who cannot provide consent for the study Known case of psychiatric disease