Inclusion Criteria:  Age: 18 years or older Patients with a resectable NSCLC Definite stage I to IIIA Performance status of 0, 1 or 2 Normal end organ functions Written and signed informed consent form Subjects must be covered by public health insurance.  Exclusion Criteria:  Any previous systemic neoadjuvant treatment: targeted therapy, chemotherapy, immune checkpoint blockade Previous radiotherapeutic neoadjuvant treatment Resection margins R1 and R2 Non-invasive lung carcinoma Multiple primary lung cancer. Previous malignancy during the past 3 years (except non-melanomatous skin cancer) Preexisting interstitial lung disease Positive serology for following infections: HIV, active viral B hepatitis or C hepatitis Patient with any other situation responsible for cirDNA rate increasing (active auto-immune disease, 10 days following blood transfusion) Patient unable to attend all scheduled visits Woman of childbearing age without efficient contraception, breastfeeding or in pregnancy, these situations modifying significantly the levels of cirDNA detectable in blood. Patient with a legal protection measure (guardianship, curatorship) Vulnerable patient protected by law