Inclusion Criteria:  Suspected primary lobar Glioblastoma clearly measurable on the basis of Response Assessment in Neuro-Oncology (RANO) criteria Brain glioblastomas located in a surgically accessible brain region for resection The targeted tumor resection volume measures between 1cm and 5cm in diameter. Karnofsky rating 70-100 American Society of Anesthesiologists (ASA) score 1-3 Able to attend all study visits No previous brain surgery No previous radiation treatment No previous systemic treatment for the tumor Able and willing to give informed consent  Exclusion Criteria:  Brain glioblastoma presenting with the following characteristics: Brain edema and/or mass effect that causes midline shift of more than 10 mm Evidence of recent intracranial hemorrhage within the targeted tumor volume Calcifications in the focused ultrasound sonication path (system tools may not tailor the treatment around these calcifications) The sonication pathway to the tumor involves either: More than 30% of the skull area traversed by scars, scalp disorders (e.g. eczema),or atrophy of the scalp Clips, shunts, or other metallic implanted objects in the skull or the brain  Cardiac disease or unstable hemodynamic status including:  Documented myocardial infarction within six months of enrolment Unstable angina on medication Congestive heart failure Left ventricular ejection fraction < 50% Right-to-left, bidirectional, or transient right-to-left cardiac shunts History of a hemodynamically unstable cardiac arrythmia Cardiac pacemaker Severe hypertension Anti-coagulant therapy or medications known to increase risk of hemorrhage within washout period prior to treatment History of a bleeding disorder, coagulopathy or with a history of spontaneous tumor hemorrhage Abnormal level of platelets (<100000) or international normalized ratio (INR) >1.3 Cerebral or systemic vasculopathy Known allergy sensitivity or contraindications to gadolinium Contraindications to MRI such as non-MRI-compatible implanted devices Subjects not fitting comfortably into the MRI scanner Difficulty lying supine and still for up to 4 hours in the MRI unit or claustrophobia Positive pregnancy test (for pre-menopausal women) Severely impaired renal function with estimated glomerular filtration rate <30 mL/min/1.73m2 and/or on dialysis Respiratory: chronic pulmonary disorders, e.g. severe emphysema, chronic obstructive pulmonary disease (COPD), pulmonary vasculitis, or other causes of reduced pulmonary vascular cross-sectional area. Any illness or medical condition that in the investigator's opinion precludes participation in this study Patients unable to sign a consent form