Inclusion Criteria:  Adults ≥ 18 years Esophagectomy surgery requiring one-lung ventilation for > 120 minutes  Exclusion Criteria:  Severe heart disease (LVEF (Left ventricle ejection fraction) <50%) and/or Heart failure with CI (cardiac index) <2.5 l/min/m2 or need of vasopressors and/or ionotropic support Genetic alterations of hemoglobin Pregnant patients History of severe restrictive lung disease (such as pulmonary fibrosis with minimal FEV1 of <75% or COPD/emphysema with minimal FEV1 of <50%) which may affect inflation/deflation times Trauma patients requiring VATS/thoracotomy Patient with recent mechanical ventilation support (2 weeks)