Inclusion Criteria:  Inclusion in the STROKE-CARD Registry Study Modified Rankin Scale (mRS) < 5 Provision of signed and dated informed consent form Willingness to comply with all study procedures and ability to participate in the study over the complete study duration  Exclusion Criteria:  Persistent motor deficit before the onset event Not able to walk without walking aid or not able to put the full bodyweight on either leg before the onset event Medical history of stroke Premedication with Corticosteroids for more than 6 Weeks or Pioglitazone or Bisphosphonate within the last 12 months Limb amputation BMI < 18,5 kg/m2 or > 35 kg/m2 Present or previous fracture in the distal Radius or Tibia interfering with HR-pQCT Movement disorder interfering with HR-pQCT imaging Women of childbearing potential