Inclusion Criteria:  Age>=18Y; Good Organ Function; Expected survival time ≥ 3 months; Advanced BRAF V600 ATC that have been diagnosed histologically; At least one measurable lesion as per RECIST v1.1; ECOG score 0-1.  Exclusion Criteria:  Pregnant or lactating women; Previous treatment with BRAF inhibitors or MEK inhibitors; A history of other malignancies within two years, except for cured cervical carcinoma in situ, basal cell carcinoma of the skin; Severe active infections requiring systemic anti-infective therapy.