Inclusion Criteria:  Subject informed and having signed the consent Age ≥ 18 years old Affiliation to a social security Indication for carrying out a screening or diagnostic test for COVID-19  For the study of diagnostic performance in symptomatic hospitalized patients, at least one of the following criteria (HAS recommendations - June 2020):  Respiratory rate> 25 / min Pulse> 100 / mn SpO2 <94% Dyspnea Presence of HCSP comorbidities Unfavorable psycho-family environment  For the study of diagnostic performance in asymptomatic patients:  ● No symptoms of respiratory infection present (fever, chills, sweating, headache, myalgia, feeling sick, cough, rhinorrhea or sputum, sore throat, chest pain)  For the study of diagnostic performance in symptomatic or pauci-symptomatic patients who are not hospitalized:  ● None of the criteria of the two previous populations  Exclusion Criteria:  Contraindication to performing a nasopharyngeal sample or inability to perform the nasopharyngeal sample Subject who has already participated in the study All categories of persons protected according to the CSP (minor subject, pregnant, deprived of liberty, under measure of legal protection, guardianship or curators) Lack of social security affiliation, CMU (or equivalent) Subject under AME Lack of signed informed consent  For the study of diagnostic performance in pauci-symptomatic patients  • Need for nasal oxygen therapy  For the study of diagnostic performance in asymptomatic patients  Presence of respiratory symptoms suggestive of viral infection of the upper respiratory tract Need for nasal oxygen therapy