Inclusion Criteria:  Admitted covid 19 patients to the ICU with the following criteria : :  Hypoxia (P/F less than 100) Need for high level of oxygenation or ventilatory support Tachypnea, respiratory distress due to hypoxia  >50 percent involvement of the lung parenchyma on chest imaging .  Serum IL-6 ≥ 5 x upper normal limit of daily increase of >1 time Ferritin >300 ug/L with doubling within 24 hours Ferritin >600 ug/L at presentation LDH >250 U/L Elevated D-dimer (>1 mg/L)  Exclusion Criteria:  1- Patients with hemodynamic instability or multiorgan failure 2- Failure to obtain temporary vascular access under ultrasound guidance or due to bleeding tendency.