Inclusion Criteria:  Healthy men and women 18-60 years Speak and understand English  Exclusion Criteria:  Pregnancy or lactation Drug addiction defined as any use of cannabis, opioids or other drugs Previous or current neurologic, musculoskeletal or mental illnesses that may affect the results (e.g. neuropathy, muscular pain in the upper extremities, etc.). Lack of ability to cooperate Current use of medications that may affect the trial such as antihistamine medications or pain killers. Skin diseases Hypersensitivity to papaya and mango fruit, cashew nuts and rubber latex Consumption of alcohol or painkillers 24 hours before the study days and between these Acute or chronic pain Participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical trials) Known history of anaphylactic shock, or local allergy (contact dermatitis) to lidocaine, prilocaine or other local anaesthetics of the amide type.