Inclusion Criteria:  Patient consent. Patients between 6-60 years old suffering from allergic rhinitis clinically. Positive skin prick test  Exclusion Criteria:  1- Chronic inflammatory condition as COPD, tuberculosis, aspergillosis and chronic hepatitis.  2- Other allergic diseases as bronchial asthma, allergic conjunctivitis and chronic urticaria 3- Those undergoing chronic treatment with systemic steroids or B- blockers 4- Systemic immunological disorders as systemic lupus erythematous, rheumatoid arthritis and systemic sclerosis.  5- Malignancy