Inclusion criteria:  patients with aneurysmal aortic disease / aortic rupture; patients with ischemic heart disease and dysfunction of the valves; patients with initially low heart ejection fraction (less than 45%)  Exclusion criterion:  tolerance to antibacterial drugs; taking oncological chemotherapy drugs; taking probiotics and nutritional supplements within the last month; intraoperative complications (shock of any etiology, allergic reactions).