Exclusion criteria:  Individuals who do not wish to complete the treatment protocol Individuals with healthy periodontium pregnant women Infants Individuals who use drugs Individuals with systemic alterations Individuals who used antibiotics in the last 3 months Individuals with systemic diseases that require antibiotic prophylaxis before periodontal therapy Immunosuppressed individuals  Inclusion criteria:  Individuals of both sexes Individuals without a history of systemic complications for more than 6 months Individuals with no recent history of drug use Systemically healthy individuals Individuals with periodontal disease