Recipient Inclusion Criteria  In order to be eligible to participate in this study, a potential recipient must meet all of the following criteria prior to transplant procedure:  General inclusion criteria:  Male or female, aged 18 - 65 years old inclusive, at study entry Willing and able to provide written informed consent Reside in the United States Negative serum pregnancy test for women of childbearing potential  Cancer-related inclusion criteria:  Eastern Cooperative Oncology Group (ECOG) : 0 or 1 at all times prior to LDLT Biopsy-proven colorectal LM  Tumor must have the following characteristics  Non-resectable LM (by consensus of three hepatobiliary (HPB) surgeons). All potential recipients will be presented at Multidisciplinary Tumor Rounds for discussion of treatment options Synchronous or Metachronous disease R0 resection can be achieved by total hepatectomy Time from primary CRC resection to transplant is ≥6 months Primary CRC tumor stage is ≤T3 and ≤N1 Maximum tumor diameter <5.5cm Favorable carcinoembryonic antigen (CEA) trend (for CEA producing tumors) and, less than 80 nanograms per milliliter prior to LDLT The patient has undergone first-line "standard of care" chemotherapy for a minimum of 3 months (at the time of screening), with demonstrated stability or regression of LM based on RECIST v 1.1 criteria The only site of metastases is the liver (Staging CT scans are clear of metastases)  Transplant related inclusion criteria:  At least one ABO compatible living donor has been identified, and has completed an intake history which, upon review by the Living Donor team, is deemed acceptable and demonstrates no obvious contraindications to donation (Altruistic donors will not be accepted for the study). Complete colonoscopy within the 12 months prior to potential recipient's inclusion, showing no signs of local recurrence Prior authorization by private insurance as a single payer exception is required. This will be discussed on a case-by-case basis with the insurance providers and the Transplant Financial Group Creatinine clearance greater than or equal to 50 ml/min Absolute neutrophil count greater than or equal to 1,500/uL Child-Pugh score of A Meets criteria to undergo a liver transplantation  Recipient Exclusion Criteria:  A potential recipient who meets any of the following criteria will be excluded from participation in this study:  General exclusion criteria:  Substance abuse, medical, psychological or social conditions that may interfere with the potential recipient's participation in the study or evaluation of the study results Known or suspected allergy to any agent given in association with this trial Any condition that is unstable or which could jeopardize the safety of the potential recipient and his/her compliance in the study Pregnant or breast-feeding patients  Cancer-related exclusion criteria:  Previous or concurrent cancer that is distinct in primary site or histology from adenocarcinoma, except ductal carcinoma in situ, cervical carcinoma in situ, localized prostate cancer, treated basal cell carcinoma, superficial bladder tumors (Ta, Tis & T1). Any cancer curatively treated 5 years prior to entry is permitted Progression of LM at any time point prior to transplant surgery LM show no major vascular invasion: no vena cava involvement and no porta hepatis involvement as seen on scans (including PET-CT), or through endoscopic ultrasound and exploratory laparotomy sampling of porta hepatis lymph nodes BRAF+ mutation or microsatellite instability of either primary tumor or LM  Transplant-related exclusion criteria:  Renal dysfunction with an estimated creatinine clearance of less than 50 ml/min Pulmonary insufficiency (history of chronic obstructive pulmonary disease and FEV1 /FVC < 75%)  History of cardiac disease:  Congestive heart failure > New York Heart Association (NYHA) class 2 Non-revascularized coronary artery disease Uncontrolled hypertension (two systolic blood pressure readings greater than 150 in past 2 visits) Uncontrolled infection(s) as defined per surgeon, subject may be on antibiotics at time of transplant Severe liver dysfunction (Child-Pugh Score of B or C will be excluded) History of solid organ transplantation  Donor eligibility criteria:  In order to be eligible to participate in this study, a potential donor must meet all of the following criteria prior to transplant procedure:  Willing and able to provide informed consent Upon review by the Living Donor team, is deemed acceptable and demonstrates no obvious contraindications to donation Not an altruistic donor Before transplant surgery, must be approved as a liver donor by UW Health Transplant Program