Inclusion Criteria:  All individuals aged 18 to 65 years It has been confirmed positive for COVID-19 by throat swab / sputum / brochoalveolar lavage (BAL) with real-time reverse transcription polymerase chain reaction (RT-PCR) Categorized as a severe case of COVID-19 patient Agree to participate and sign the informed consent  Exclusion Criteria:  History of allergy to penicillin, streptomycin, and amphotericin-B Have any cancer conditions Active in other intervention studies Have had other intervention studies in the last 3 months