Inclusion Criteria:  Participants must be >18 years and <80 years Participant has a temporary loop ileostomy that was created ≥ 2 months but ≤ 10 months prior to reversal Preoperative clearance with confirmation of anastomotic integrity of the original resection; i.e., absence of active exacerbation of inflammatory disease (as applicable), stricture or leakage at or distal to the diverted colorectal anastomosis via gastrografin enema and/or endoscopy based on physician's discretion BMI ≤ 40 kg/m2 American Society of Anesthesiologist (ASA) score < IV at time of reversal All cancer patients must have completed chemotherapy ≥2 months prior to ileostomy closure Subject or authorized representative have been informed of the nature of the study and has provided written informed consent approved by the appropriate local Institutional Review Board (IRB) and agrees to comply with all protocol-specified follow-up appointments  Exclusion Criteria:  Radiological or clinical signs of anastomosis leak, active infection (except uncomplicated urinary tract infection) Ongoing or prolonged ileus or bowel obstruction from original surgery Index operation was a total proctocolectomy or palliative stoma Requires/d additional abdominal surgery (e.g., Major hernia repair, either necessitating mesh and/or abdominal wall reconstruction) after ileostomy or requires/d concurrent abdominal surgery during reversal procedure Multiple small bowel obstructions occurring between ileostomy creation and closure requiring a formal abdominal exploration through a midline incision at the time of ileostomy closure or any other participant in whom laparotomy is required at time of ileostomy closure Requires/d laparotomy at time of ileostomy closure Congestive heart failure with ejection fraction<35% or clinically significant arrhythmia (any rhythm disturbances except sinus tachycardia, sinus bradycardia or a sinus rhythm with premature atrial or ventricular complexes) Decompensated chronic obstructive lung disease Pulmonary embolism or myocardial infarction in the prior 6 months Congenital or acquired anomalies of the gastrointestinal tract, including atresias, stenosis, luminal distortion or malrotation Coagulation deficiency not normalized by medical treatment or platelet count <50,000/µL at time of reversal Known moderate to severe renal disease (eGFR < 44 milliliters per minute per 1.73m2) or ongoing dialysi