Inclusion Criteria:  Children with noninfectious uveitis aged between 4-16, weight ≥ 30kg. Uveitis resistant to well conducted topical steroid therapy for three months, or uveitis resistant to well conducted 0.1% prednisolone twice a day for one month Retina peripheral vascular leakage demonstrated by UWFFA at the time of inclusion.  Exclusion Criteria:  Any contraindication to administration of immunosuppressive therapy (active tuberculosis, immune deficit, opportunistic infection, other severe chronic disease). Previous diagnosis or signs of demyelinating disease of the central nervous system. Children unable to cooperate with examinations and follow-up. Positive allergy skin test when conducting fluorescence fundus angiography. Diffuse vascular leakage, macula edema or any retina lesions demonstrated by UWFFA. History of oral immunosuppressive drug treatment within 2 months History of biological treatment within 2 months History of triamcinolone acetonide subconjunctival/intraocular injection within 3 months Current topical steroid use more than six times per day History of eye surgery within 3 months. Eye complications that interfere with fundus observation.