Inclusion Criteria:  Participant must be able to understand and provide informed consent No evidence of infectious illness (defined as fever >38 degrees celsius, vomiting, diarrhea, new cough, new shortness of breath, new congestion, new runny nose, new headache or sore throat) within 14 days of vaccine administration. Participant must have a history of adverse reaction to the Pfizer-BioNTech mRNA COVID vaccination within the past 3 months. Females of childbearing potential must have a negative pregnancy test prior to vaccination.  Exclusion Criteria:  Evidence of COVID-19 infection within 21 days of vaccination visit History of antibody agent or convalescent plasma for treatment or prevention of COVID-19 within 90 days Individuals with known history of a severe allergic reaction (e.g., anaphylaxis) to any component of Pfizer-BioNTech mRNA COVID-19 vaccination History of underlying immune disorder. Pregnancy Immunocompromised Participants with primary or acquired immunodeficiency Participants on anti-rejection therapy following solid organ transplant or bone marrow transplant Participants on biologic therapeutic agents Participants with malignancy and ongoing or recent chemotherapy Participants receiving systemic immunosuppressive therapy, including corticosteroids equivalent to 20 mg/day of prednisone for 2 weeks Participants with chronic kidney disease stage 3 or higher Participants with history of significant pulmonary compromise