Inclusion Criteria For Case:  Hospitalized adults 65 years or older, Presenting with bacteremia with positive blood culture (excluding catheter related infections) and/or WHO Severe Acute Respiratory Infection (SARI) case definition Upper respiratory infection = SARI (fever or history of fever >38°C, cough, onset of the disease within the last 10 days and requires hospitalisation) Lower respiratory infection = SARI with confirmed CT/CHR Informed consent form signed Patient affiliated to social security insurance  Exclusion Criteria For Case:  Bedridden or terminally ill patient (based upon a threshold of ADL: ≤2 TBD, or CLINICAL FRAILTY SCALE: ≥8 ) Patients that refuse the 3- and 6-months follow-up phone call assessments Patients that will not be able to answer the 3- and 6-months follow-up phone call assessments via a nurse Subject in exclusion period for another study, Subject who cannot be contacted in an emergency Persons referred to in Articles L1121-5 to L1121-8 of the French code of public health (this corresponds to all persons protected: pregnant or parturient women, breastfeeding mothers, persons deprived of liberty by judicial or administrative decision, persons subject to a legal protection measure).  Inclusion Criteria For Controls  Same age (+/- 3 years) same sex, without suspicion of infection Hospitalized during the past or upcoming month in the same centre. Informed consent form signed Patient affiliated to social security insurance  Exclusion Criteria For Controls  Bedridden or terminally ill patient (based upon a threshold of ADL: ≤2 TBD, or CLINICAL FRAILTY SCALE: ≥8 ) Patients that refuse the 3- and 6-months follow-up phone call assessments Patients that will not be able to answer the 3- and 6-months follow-up phone call assessments via a nurse Subject in exclusion period for another study, Subject who cannot be contacted in an emergency Persons referred to in Articles L1121-5 to L1121-8 of the French code of public health (this corresponds to all persons protected: pregnant or parturient women, breastfeeding mothers, persons deprived of liberty by judicial or administrative decision, persons subject to a legal protection measure)