Inclusion Criteria:  Chinese healthy male or female Subjects with skin problems such as skin dullness, skin tone unevenness, skin inelasticity, skin dryness, and wrinkle/fine lines. Subjects without any other chronic or on treatment diseases Subjects are voluntary to participate the trial and signed informed consents. Subjects are voluntary to follow all evaluation criteria  Exclusion Criteria:  Subjects have a plan to be pregnant, or are in pregnancy or lactation period; Not participated any clinical trial or evaluation within nearly 1 month; Used anti-histamine medication within nearly one week or immunosuppressor within nearly one month Used any anti-inflammation drugs at test site within nearly two months Subjects who have any skin diseases (psoriasis, eczema, skin cancer etc.) Subjects with Type I diabetes Subjects who currently are receiving asthma or other chronic respiratory diseases treatment Subjects who are receiving anti-cancer chemotherapy in nearly 6 months Subjects who have anyother health problem or chronic diseases Subjects who have externally used Vit A, a-hydroxy acid, salicylic acid, hydroquinone within nearly 3 months or prescription medicines, oral contraceptive within nearly 6 months Expert or professional person evaluate have other iatrogenic reason may impact the evaluation results