Inclusion Criteria:  ASA physical status I- II body mass index (BMI) ˃ 35 scheduled to undergo laparoscopic gastric bypass  Exclusion Criteria:  Patients' refusal hypersensitivity to the study medications patients with known history of; hepatic disease, renal dysfunction severe renal impairment (eGFR <30ml/min/1.73m2) heart failure; left ventricular ejection fraction than 35% any cardiac dysrhythmias; Adam-Stokes syndrome; Wolff- Parkinson-White syndrome, atrio-ventricular block with heart rate below 50 bpm chronic pain concomitantly taking beta blocking drugs •substance abuse disorder chronic opioid use.