Inclusion Criteria:  Patients of both sexes, aging 18 - 60 years after written informed consent Patients with sepsis on admission according to the new sepsis definition in 2016 (life-threatening organ dysfunction due to a dysregulated host response to infection) Hemodynamically stable without or with low dose support Patients on mechanical ventilation for at least 48 hours and not more than 1 week Patients ready for start of weaning protocol, fully conscious, on continuous positive airway pressure (CPAP) mode with positive end expiratory pressure (PEEP) 3-5 Centimetre water (CmH2O), Pr. Supp. <15 CmH2O, Fio2 less than 60%, Respiratory rate less than 35 breath/min, partial oxygen pressure (PO2)/FIO2 >200, Rapid Shallow Breathing Index (RSBI) is less than 105  Exclusion Criteria:  Patients aged less than 18 years or more than 60 years old Patients in septic shock, hemodynamically unstable or on high dose support Patients on mechanical ventilation for more than 1 week or less than 48 hours Patients not ready for start of weaning from mechanical ventilation Patients with neuromuscular disorders Pregnant females in the second and third trimester, patients with tense ascites or morbidly obese with body mass index more than 40 kg/m2