Inclusion Criteria:  Age 20--90  newly ICU admission (<48 hours) APACHE score <30 Less than 3 inotropic medicine use Fi02< 60%.  Exclusion Criteria:  • Coagulopathy: Prolong Prothrombin Time (PPT) activated Partial Thromboplastin Time (aPTT) more than 4 times  Thrombocytopenia - low platelet count Clinically unstable: receiving two or more inotropic agents or Fraction of Inspired Oxygen (Fi02) >60% Primary central nervous system disorder: stroke, traumatic brain injury, central nervous system infections, brain tumors, recent intracranial surgery Already under other traditional medicine intervention during hospitalization Skin damage of more than 20% of the body skin.