Main Inclusion Criteria:  Be healthy males, non-smokers, ≥18 and ≤45 years of age; Able to attend all scheduled visits and to comply with all study procedures.  Main Exclusion Criteria:  Clinically significant illness or surgery within 4 weeks prior to dosing; Any clinically significant abnormality or abnormal laboratory test results found during screening; Positive test for hepatitis B, hepatitis C, or HIV at screening; Clinically significant vital sign abnormalities at screening; History of significant alcohol or drug abuse within one year prior to the screening visit; History of severe allergic or hypersensitivity reactions; Use of an investigational drug or participation in an investigational drug trial within the last 4 weeks; Any clinically significant history or presence of neurological, cardiovascular, pulmonary, hematological, immunologic, metabolic or other uncontrolled systemic disease; Clinically significant history or known presence of psychiatric disorders, including but not limited to depression, anxiety, and sleep disorders; Body organ transplant and are taking immunosuppressants; History of malignant disease; History or presence of endocrine disorders; History of coagulation disorders and blood dyscrasias; Inability to comprehend the written consent form.