Inclusion Criteria:  Informed consent signed by the patient (ages 14 to 18) and / or his legal representative (ages 0 to 18). The patient has an indication for allogeneic transplantation of hematopoietic stem cells established in accordance with the current regulatory framework Planned HSCT selective immunomagnetic depletion of alpha/betta T lymphocytes Karnovsky or Lansky index more than 50% Life expectancy at least 4 weeks Heart function: ejection fraction of at least 40% Consent to continue follow-up for 5 years  Exclusion Criteria:  Acute viral hepatitis or acute HIV infection Hypoxemia with SaO2 <90% Bilirubin> 3 norms Creatinine> 3 norms Pregnancy and lactation Severe uncontrolled infection Severe (>?) pathology of the central nervous system (epilepsy, dementia, organic damage to the central nervous system, psychosis)