Inclusion Criteria:  Age >18years Danish speaking Open angle glaucoma or ocular hypertension Average intraocular pressure equal to or above 22 mmHg based on 3 measurements on each eye  Exclusion Criteria:  history of significant eye diseae (including okular trauma) other than open angle glaucoma and ocular hypertension Pressure difference equal to or above 4 mmHg between eyes corneal thickness <450μm or >600μm treatment with steroids within the last 3 months from inclusion Significant untreated systemic disease such as hypertension, heart failure, diabetes mellitus, stroke, lung disease and autoimmune diseases. Diseases are not reason for exclusion if they are well treated or does not need treatment smoker at inclusion pregnant or breast feeding women using unsafe anticonception allergy towards trial medication patients who cannot cooperate in eye examination ocular surface defects need for polytherapy in glaucoma treatment