Inclusion Criteria:  Selected teeth: Permanent first and second molars in the mandible. Furcation dimension: Radiographic and clinical evidence of exhibiting defects due to Grade II furcation with at least 2 millimeters probing depth horizontally and at least 5 millimeters probing depth circumferential. Gender: both males and females. Age range: between 18 and 55 years. Health status: healthy patients non-systemic diseased except controlled diabetic. Compliance: Patients will be willing and able to comply with adequate oral hygiene protocols.  Exclusion Criteria:  Patients that received periodontal regenerative therapy within the past 12 months. Patients that are lactating. Pregnant patients. Smokers. Patients with pulp infection. Patients with trauma resulting from occlusion. Patients with receding gum. Patients with tooth mobility greater than grade II. Patients that will not comply with the hygiene protocols in Phase I therapy. Patients with potential illnesses that can influence the periodontal therapy outcomes. Patients that are taking medications that can interfere with the healing outcomes of the periodontal wound. Patients allergic to any drugs.