Inclusion Criteria:  Evidence of a personally signed and dated informed consent document indicating that the subject (or a legal representative) has been informed of all pertinent aspects of the study. Subjects who are willing and able to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures. Age of ≥18 years Bacteriologically confirmed pulmonary TB (determined by Xpert, culture, or microscopy) Confirmed HIV-1 infection. On TB treatment for ≤ 7 days at the time of enrolment (Within this time, the patient is still expected to have mycobacteria present in sputum and will provide enough time to conduct screening procedures)  Exclusion Criteria:  TB infection of any organ/systems requiring TB treatment longer than 6 months Pregnancy Decompensated liver disease and/or aminotransferases >2.5 x ULN