For more information regarding participation in the Trial, please refer to your physician  Inclusion Criteria:  Women and men ≥18 years of age with Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 Subject with histologically or cytologically confirmed advanced solid tumor for whom no standard treatment is further available. At least 4 weeks since any previous treatment for cancer Subject must consent to pretreatment and on treatment tumor biopsies Adequate organ and marrow function  Exclusion Criteria:  Patients with primary brain tumors or primary tumors with central nervous system metastases as only location of disease. Controlled brain metastases are permitted Participants with second/other active cancers requiring current treatment Uncontrolled/significant heart disease Known History of chronic hepatitis, Positive test for Hepatitis B virus surface antigen or - - Hepatitis C antibody (except participants with liver cancer) or Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome(HIV/AIDS) Active/uncontrolled autoimmune disease Active infection Other protocol defined inclusion/exclusion criteria could apply