Inclusion Criteria:  Suspected central line-associated bloodstram infection defined as:  Catheterization with a non-tunneled CVC and Clinical signs of local catheter infection or any increase in humoral inflammatory markers (PCT, CRP, WBC) or elevated body temperature ≥ 38.3°C not otherwise explained.  Baseline CRP at screening ≥ 100 mg/L  Exclusion Criteria:  known positive blood cultures at the time of randomization High risk situation warranting immediate empiric antibiotic therapy: endovascular implant (prosthetic valve, pacemaker, vascular graft) high-risk for endocarditis warranting endocarditis-prophylaxis Septic shock Catheter replacement not feasible or no further indication for central venous catheterization Known hypersensitivity to vancomycin or any component of the formulation. Administration of Vancomycin, Teicoplanin, Daptomycin or Linezolid <48 hours before enrolment. Enrolment in another clinical study Pregnancy