Inclusion Criteria:  Part 1: Obese Otherwise Healthy Males Part 2: Males or Females with T2D Part 1: BMI 30.0-35.0, inclusive Part 2: BMI 27.0-45.0, inclusive 18-65 years old, inclusive Stable body weight for 2 months  Exclusion Criteria:  Significant medical history Uncontrolled hypertension History of malignancy