Inclusion Criteria:  Patients aged 21 years or younger at the time of enrollment on this study of any gender, race, or ethnicity. Subjects with suspected or confirmed diagnosis of all types of sarcomas. Subjects who are scheduled for or have recently had biopsy or tumor excised (solid tumors) or bone marrow aspirate (blood cancers). Subjects are willing to have a blood draw or buccal swab done for the purposes of genetic testing. Subjects or their parents or legal guardians willing to sign informed consent. Subjects aged 7 to 17 willing to sign assent.  Exclusion Criteria:  Subjects who do not have malignant tissue available and accessible. The amount of excised malignant tissue is not sufficient for ex vivo drug testing and/or genetic profiling. Patients with other types of tumors and tumors that have a high (>90%) cure rate with safe standard therapy.