Inclusion Criteria:  Eastern Cooperative Oncology Group (ECOG) performance status score of 0 to 1. Life expectancy >=3 months. Female patients of childbearing age should agree to use contraceptive measures during the study period and for at least 6 months after study is stopped; male patients should agree to use contraception during the study period and for at least 6 months after study is stopped. Understood and signed an informed consent form.  Exclusion Criteria:  Diagnosed and/or treated additional malignancy within 5 years before the first dose. With factors affecting oral medication. Received major surgical treatment, open biopsy or obvious traumatic injury within 4 weeks before the first dose. A history of psychotropic drug abuse or have a mental disorder. Any severe and/or uncontrolled diseas. Has received Chinese patent medicines with anti-tumor indications within 2 weeks before the first dose. Has participated in other clinical studies within 4 weeks before the first dose. According to the judgement of the investigators, there are other factors that subjects are not suitable for the study.