Inclusion Criteria:  Patients with T2DM diagnosed at least one year ago. That they are outpatients. Between 25 and 65 years old.  Exclusion Criteria:  Smoking patients. Lactose intolerance. Pregnancy or breastfeeding. Presence of kidney, liver, immunodeficiency, inflammatory bowel disease or thyroid disorder. Use of insulin, estrogen, progesterone or diuretic injections. Consumption of probiotic supplements two months before the start of the study