Inclusion Criteria:  Participant is scheduled to undergo an elective open surgery on the liver; Participant is willing and able to give written informed consent for investigation participation; Participant is 18 years of age or older at the time of enrollment; Participant has been informed of the nature of the clinical investigation.  A participant must meet all of the following intraoperative inclusion criteria to be treated with the investigational device:  Participant in whom the Investigator is able to identify a target bleeding site at the liver resection plane for which any applicable conventional means for hemostasis (e.g. suture, ligature or cautery) are ineffective or impractical and the choice is made to use a topical hemostat for control of hemostasis; and the choice is made to use a topical hemostat for control of hemostasis; Participant has a minimal, mild, or moderate target bleeding;  Exclusion Criteria:  Participant is scheduled to undergo surgery on other organs besides the liver (e.g. pancreas, colon, lungs); Participant is taking multiple antithrombotic therapies in therapeutic dosage up to the time of surgery, allowing exclusive use of acetylsalicylic acid; Participant has platelet count <100 x 10ˆ9/L, an activates partial thrombin time of >100s, or international normalized ratio >2.5; Participant is pregnant, planning on becoming pregnant or actively breast-feeding during the follow-up period; Participant has a known hypersensitivity to brilliant blue (FD&C Blue #1); Participant has an active or suspected infection at the surgical site; Participant has a total bilirubin level of ≥ 2.5 mg/dl Participant has had or has planned to receive any organ transplantation; Participant has American Association of Anesthesiologists (ASA) classification of 4/5; Participant has a life expectancy of less than 3 months; Participant has a documented severe congenital or acquired immunodeficiency; Participant in whom the investigational device will be used at the site of a synthetic graft or patch implant; Participant is currently participating or has participated in another clinical investigation within the past 30 days that may affect the endpoints of the study, such as trials related to the surgical procedure, and on anti-coagulation; Participant is not appropriate for inclusion in the clinical investigation, per the medical opinion of the Investigator; Participant has any incidental (pre- and peri-operative) findings deemed by the Investigator to potentially jeopardize the safety or welfare of the patient