Inclusion Criteria:  > 18 years old at the date of consent Subjects referred for EMR for the excision of:  Treatment naïve, laterally spreading sessile, flat polyps or adenomas of the colon equal to or greater than 20 mm in largest dimension, assessed by the investigator to be suitable for EMR or ESD.  Exclusion Criteria:  Lesions less than 20 mm in largest dimension Subjects with ulcerated depressed lesions (Paris type III-excavated) or biopsy proven invasive carcinoma Scarred polyps Endoscopic appearance of deep invasive malignancy Previous partial resection or attempted resection