Inclusion Criteria:  Patients of both sexes aged 18 years or older Patient with a validated indication for colonoscopy for colorectal lesions Patients with a single colorectal lesion to be resected by ESD according to European recommendations. Patients with a colorectal neoplastic lesion (≥3 cm) Patients taking anticoagulants (acetylsalicylic acid >300 mg/day) or antiplatelet agents (clopidogrel, prasugrel, ticagrelor, clopidogrel) and managed according to European recommendations for ESD (including patients who may require heparin replacement) Written consent signed after clear, fair, and understood information. Patients with social security coverage.  Exclusion Criteria:  Patients who may have an allergic reaction to the substances of PuraStat®. Patients with severe fibrosis Patients with a history of familial colorectal polyposis (familial adenomatous, Lynch syndrome, Peutz-Jeghers syndrome) Patients with a score ASA greater than or equal to 4 or 5 Patients with a platelet count of 50,000/mm3 Patients with acquired (non-medicated) or inherited bleeding disorders Patients who are being treated with acetylsalicylic acid but whose treatment is discontinued at the time of the procedure (therapeutic window) Patients with advanced cancer or inflammatory bowel disease, including ulcerative colitis (with colonic involvement) Contraindication to general anesthesia Patients with a mental disorder, drug addiction, alcoholism, etc. Pregnant women or women wishing to become pregnant during the study Patients already participating or scheduled to participate in other clinical trials Lesion that has been previously resected by mucosectomy Patient with an initial metastatic lesion prior to colonoscopy. Patient unable to give personal consent Lack of signed informed consent