Patients:  Inclusion Criteria:  Patients aged 18-80 years who visit Peking University Third Hospital, Beijing, China from December 2020.  Patients who diagnosis MND/FTD spectrum disease (including ALS, FAS, FLS, PLS, PBP, PMA, FTD, MND-FTD) by an experienced neurologist strictly according to a list of diagnosis criteria and clinical guidelines  Informed consent signed Exclusion Criteria  Patients who receive alternative diagnoses during the follow-up. Patients who refuse to sign informed consent.  Control group:  Control group consists of individuals matched for gender and age with the patients who are mainly the caregivers of the patients, including but not limited to the patients' spouses and their long-term nurses.  Exclusion criteria:  Suffering from neurological disease, including but not limited to motor neuron disease/frontotemporal dementia spectrum disease, dementia, Alzheimer's disease, Parkinson's disease, multiple sclerosis, neuromyelitis and so on. Individuals who refuse to sign informed consent.