Inclusion Criteria:  Cases:  Acute lymphoblastic leukemia survivor, OR living with chronic lung disease of prematurity, OR living with heart transplant 8-25 years old Height: ≥ 48 inches Ambulatory without assistance English speaking Normotensive (<95th percentile for age; okay if managed with antihypertensive medication) SpO2 >92% Not pregnant ALL survivor specific: must have completed therapy ≥ 3 months prior to study entry  Controls  8-25 years old Height: ≥ 48 inches Ambulatory without assistance English speaking No history of arrhythmia or known cardiac dysfunction at baseline Normotensive (<95th percentile for age; okay if managed with antihypertensive medication) SpO2 >95% Not pregnant  Exclusion Criteria:  Cases:  ALL specific: received cranial radiation, bone marrow transplant recipients Investigator or patient's primary physician deems the patient unsuitable for the study  Controls:  History of malignancy, CLD or HT or any other diagnosis which may reduce cardiorespiratory function Investigator deems the patient unsuitable for the study