Inclusion Criteria:  Treatment-naïve patients with operable locally advanced cancer (LARC, T3-4 and/or N+) Pathologically diagnosed as rectal adenocarcinoma Male or non-pregnant female Age: 18-70 years old Hematology examination：I. White blood cell count ≥4×10^9/L;II. Neutrophils ≥1.5×10^9/L;III. Platelet count ≥100×10^9/L;IV. Hemoglobin ≥9g/L Blood biochemical examination: total bilirubin, AST, ALT≤2.0×upper limit of normal; creatinine≤1.5×upper limit of normal Functional status: ECOG score 0-1 points or KPS score ≥70 points Obtain the patient's informed consent  Exclusion Criteria:  Pathologically diagnosed as non-adenocarcinoma Age> 70 years old Patients with recurrence and distant metastasis Have a history of other malignancies Have had radiotherapy and/or chemotherapy Pregnant or breastfeeding women Mentally disordered Patients with severe heart, liver, and kidney damage Non-compliance or the investigator believes that the patient cannot complete the entire trial treatment