Inclusion Criteria:  For healthy subjects:  Age 21-80 years Signed informed consent from patient or legal representative No history of neuropathy ECOG 0 No history of hospitalization in the past 6 months  For cancer patients:  Age 21- 80 years Signed informed consent from patient or legal representative Scheduled to receive weekly paclitaxel chemotherapy Patients may receive other chemotherapy drugs alongside taxane e.g. Platinum/Herceptin.  Exclusion Criteria:  For healthy subjects:  Open skin wound or ulcers of the limbs History of Raynaud's phenomenon, peripheral vascular disease, or poorly controlled diabetes Pregnant women  For cancer patients:  Open skin wound or ulcers of the limbs History of Raynaud's phenomenon, peripheral vascular disease, or poorly controlled diabetes Pregnant women