Inclusion Criteria:  Male or female ages 18 - <66 years Chronic HBV infection for >/= 6 months On NRTI therapy for >/= 2 months at the time of screening  Exclusion Criteria:  Any clinically significant chronic or acute medical condition that makes the participant unsuitable for participation Significant fibrosis or cirrhosis History or evidence of drug or alcohol abuse History of chronic liver disease from any cause other than chronic HBV infection History of hepatic decompensation History of anaphylaxis History of allergic reactions, hypersensitivity, or intolerance to monoclonal antibodies, antibody fragments, or any excipients of VIR-3434 History of immune complex disease History of known contraindication to any interferon product