Inclusion Criteria:  CLL patients with indications for treatment according to iwCLL; CT/MRI shows measurable lesions; ECOG score is 0-2; No pregnancy plans during treatment  Exclusion Criteria:  Richter transformation; 17p-/TP53 amplification ≥20% (FISH); Received steroids within 7 days before starting treatment; Have previously received treatments for chronic lymphocytic leukemia; Vaccine live attenuated vaccine within 4 weeks of randomization; Any life-threatening disease; Central nervous system leukemia; Apoplexy, history of intracranial hemorrhage; HIV or HCV or HBVpositive