Inclusion Criteria:  Good health based on medical history, physical exam, and routine laboratory testing. Female participants must have negative urine pregnancy test or be surgically sterilized or postmenopausal. Criteria for menopause are surgical menopause (hysterectomy, oophorectomy) or age > 45 years with the absence of menses for greater than 12 months. Tubal ligation with menses within the past 12 months is not considered to be surgical sterilization. Body mass index (BMI) between 18 kilogram / square meter (kg/m2) and 35 kg/m2. Willing and able to stay at the clinical research facility as required by the protocol Willing and able to comply with the investigational nature of the study and able to communicate well with investigators Ability to comprehend and willing to provide written informed consent in accordance with institutional and regulatory guidelines  Exclusion Criteria:  Known allergy to insulin. Preexisting diabetes. Current or previous use of diabetes medication or insulin. Any nasal disease or congestion that may interfere with intranasal drug absorption. Baseline hypoglycemia (blood glucose ≤ 65 mg/dL) or hyperglycemia (blood glucose > 200 mg/dL) as evident from the screening labs. Active serious disease, such as liver disease, kidney disease, uncontrolled hypertension, clinically significant hypokalemia, and significant or unstable medical illness Blood donation in excess of 500 milliliter (mL) within 60 days prior to the first dose of study medication. Treated with an investigational drug within 30 days. Individuals with inadequate venous access.