Inclusion Criteria:  diagnosed as regular dialysis patients with cardiorenal anemia syndrome Hemoglobin 60-110g / L (twice with an interval of at least 4 days); Volunteered to participate  Exclusion Criteria:  Anemia caused by diseases other than CKD Malignant tumors Active liver disease Rheumatic immune diseases in active stage Hereditary or idiopathic angioedema Systolic blood pressure≥180 mmHg;diastolic blood pressure≥110 mmHg Acute myocardial infarction and unstable angina pectoris Severe parathyroidism Active peptic ulcer taking aliskiren Mental disease Alcohol and drug abuse Allergy to test drugs