Inclusion Criteria:  Patients with a diagnosis of recurrent or metastatic squamous cell carcinoma of the head and neck region, whose planned treatment is immunotherapy, will be included. We will consider, separately, patients that had been treated with platinum before (platinum-refractory) and patients that were not submitted to this treatment (platinum naïve).  Primary site: patients with primary pharyngeal tumors (oro or hypopharynx), oral cavity and larynx will be included.  Exclusion Criteria:  Patients with cognitive impairment that prevents the proper application of questionnaires Brain metastasis Autoimmune disease Systemic immunosuppressive treatment Hepatitis B, C or HIV infection Prior immunotherapy