Inclusion Criteria:  Diagnosis of multiple sclerosis according to the revised McDonald criteria 2017. Autologous hematopoietic stem cell transplantation performed for treating multiple sclerosis at a Swedish transplantation center until December 31st 2019.  Exclusion Criteria:  Diagnosis of primary progressive MS or secondary progressive MS according to Lublin et al at the time of transplantation. Patient not accepted reporting of data to the EBMT register. Not fulfilling requirements of the minimal dataset, se below.  Definition of minimal dataset  Data on disease course of multiple sclerosis at the time of transplantation. Transplantation and the following in-patient care performed in Sweden. Date of transplantation. Data on drugs used in conditioning.  At least one follow-up visit performed in Sweden (unless early death before first follow-up visit) including data on:  Clinical assessment The Kurtzke Expanded Disability Status Scores (EDSS)  Additional note: For a patient to be included in the analysis of treatment effectiveness data on MRI evaluation is needed at least once during follow-up.