Inclusion Criteria:  Patient aged less than 6 months Sickle cell syndrome SS, Sβthal or SC confirmed by hemoglobin electrophoresis Subjects legal representatives must have signed an informed consent document indicating that they understand the purpose of and procedures required for the study and are willing to let participate their child in the study  Exclusion Criteria:  Congenital abnormality other than sickle cell disease except for a glucose-6-phosphate-deshydrogenase Prematurity Initiation of the following therapies before enrollment: chronic transfusion regimen or bone marrow transplantation