Inclusion Criteria:  patients who was diagnosed as syringomyelia including: Chiari malformation， Basilar Impression， subarachnoid obstruction， patient not received surgical or interventional treatment before， patient willing and able to participate in the registry， Hydrocephalus or other neurodegenerative disease and normal subjects.  Exclusion Criteria:  patient received surgical treatment or interventional treatment before patient is pregnant patient unable to complete follow-up patient with other spinal lesions other nervous system diseases