Inclusion Criteria:  Older dan 45 years old, With hand ostheorthritis, Regularly uses of paracetamol or NSAIDs to manage pain, Painful symptoms must have been present for more than 6 months, The patient assesses their pain on a visual pain scale and must be greater than 4 out of 10 over the last 48 hours.  Exclusion Criteria:  Related to previous and associated treatments:  Corticosteroids injection in the 3 previous months, whatever the joint concerned, Use of Slow-acting drugs for OA and/or dietary supplements taken within less than 6 months prior to the study(ex: chondroitin sulfate, diacerein, soy and avocado unsaponifiables, oxaceprol, granions de cuivre, glucosamine, phytotherapy for OA, homeopathy for OA...), Anticoagulant (coumarinic) treatment and heparin, General corticotherapy in the 3 previous months, Contraindication to paracetamol, curcumin, boswellia and NSAID's.  Related to associated pathologies:  Patient suffering from serious associated illness (liver failure, kidney failure, non-controlled cardiovascular diseases...), The patient has rheumatoid arthritis or gout, The patient has a bile obstruction.  Related to patient:  Pregnant or breastfeeding women.