Inclusion Criteria:  Male or female participants, aged 18 to 65 years, inclusive Participants who are healthy as determined by medical evaluation including medical history, physical examination, laboratory tests, and cardiac monitoring. Japanese participants must be of Japanese ancestry, defined as having been born in Japan, being descendants of four ethnic Japanese grandparents and two ethnic Japanese parents, holding a Japanese passport or identity papers, and being able to speak Japanese. Participants should have lived outside Japan for fewer than 10 years at the time of Screening. Caucasian participants must be of Caucasian ancestry, defined as Caucasian descent as evidenced by appearance and verbal confirmation of familial heritage. Body mass index (BMI) within the range of 18 to 29.9 kg/m2 (inclusive). Capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the consent form and protocol.  Exclusion Criteria:  History or presence of cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, hematological, or neurological disorders capable of significantly altering the absorption, metabolism, or elimination of drugs; constituting a risk when taking the study intervention or interfering with the interpretation of data. Lymphoma, leukemia, or any malignancy within the past 5 years except for basal cell or squamous epithelial carcinomas of the skin that have been resected with no evidence of metastatic disease for 3 years. Breast cancer within the past 10 years. Abnormal blood pressure at Screening. Significant allergies to humanized monoclonal antibodies. Clinically significant multiple or severe drug allergies, intolerance to topical corticosteroids, or severe post-treatment hypersensitivity reactions (including, but not limited to, erythema multiforme major, linear immunoglobulin A (IgA) dermatosis, toxic epidermal necrolysis, and exfoliative dermatitis). Current or chronic history of liver disease or known hepatic or biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones). Use of any prescription medications (besides contraceptive medications or devices) within the 28 days prior to dosing or concomitantly, unless permitted by the protocol or approved by the Investigator in conjunction with the GSK medical monitor. Treatment with biologic agents (such as monoclonal antibodies including marketed drugs) within 3 months or 5 half-lives (whichever is longer) prior to dosing. Receipt of convalescent plasma from a recovered COVID-19 patient or anti-SARSCoV- 2 mAb within the last 3 months. Receipt of any vaccine within 48 hours prior to enrollment. Vaccination will not be allowed for 90 days after dosing. Participant has received a SARS-CoV-2 vaccine but has not completed all doses in the series more than 28 days prior to Screening Participation in the study would result in loss of blood or blood products in excess of 500 mL within a 56 day period. Exposure to more than 4 new chemical entities within 12 months prior to the first dosing day. Enrollment in any investigational vaccine study within the last 180 days or any other investigational drug study within 30 days prior to Day 1 or within 5 half-lives of the investigational compound, whichever is longer. A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody result within 3 prior to dosing. Positive pre-study drug/alcohol screen. Positive HIV antibody test. History of regular alcohol consumption within 6 months prior to the study defined as: An average weekly intake of >14 units. One unit is equivalent to 8 g of alcohol: a half pint (~240 mL) of beer, 1 glass (125 mL) of wine, or 1 (25 mL) measure of spirits. Regular use of known drugs of abuse.