Inclusion Criteria:  Provide written consent. Body weight ≥ 50 kg, and a body mass index 18.0 to 32.0, inclusive. Female participants of non child bearing potential or if of child bearing potential, agrees to take effective contraceptive measures throughout the study period. Male participant: has undergone bilateral vasectomy or agrees to use effective contraceptive effective contraceptive measures or abstinence, and not donate sperm throughout the study until at least 3 months after the last dose of IP. Forced expiratory volume in 1 sec (FEV1)/forced vital capacity (FVC) ratio of at least 0.7. Values for FEV1 and FVC of at least 80% of the predicted value. Able to understand the nature of the study and any hazards of participation, and ability to communicate satisfactorily with the Investigator and to participate in, and comply with the requirements of, the entire study. Able to successfully perform spirometry and use the inhalation device at Screening. Negative result for cotinine in the urine drug screen, at Screening and on Day -1.  Exclusion Criteria:  Clinically significant physical findings, vital signs, ECG, or laboratory values that could interfere with the objectives of the study or the safety of the subject. Pregnant or lactating or planning to become pregnant (self or partner) at any time during the study, including the follow-up period. Presence of acute or chronic illness or history of chronic illness. Impaired endocrine, thyroid, hepatic, respiratory or renal function, diabetes mellitus, coronary artery disease, or history of any psychotic mental illness. Upper or lower respiratory tract infection within 4 weeks before the first dose of treatment. Any medically identified respiratory disease(s) and/or condition(s), including but not limited to current asthma, chronic obstructive pulmonary disease, and diagnosed obstructive sleep apnoea syndrome. Any clinically significant arrhythmia(s) at Screening ECG. History of surgery or medical intervention, or planned surgery or medical intervention, that could interfere with the objectives of the study or the safety of the volunteer. Currently taking any drug including prescription and non-prescription medications, herbal remedies, or vitamin supplements beginning 14 days before the first dose and throughout the study, with the exception of acetylsalicylic acid (aspirin). Positive test result(s) for hepatitis C virus (HCV) antibody, hepatitis B surface antigen (HbsAg), human immunodeficiency virus (HIV) antibody, or coronavirus disease of 2019 (COVID-19). Suffering from post-COVID-19 syndrome or have tested positive for COVID-19 infection within 3 months prior to the first dose of treatment. Participation in another clinical study of a new chemical entity, new device, or a prescription medicine within 3 months before dosing. Regular alcohol consumption at levels which may increase risk of harm from alcohol-related disease or injury. Participant is unwilling to abstain from alcohol beginning 48 hours prior to admission to the CRU and for the duration of the study. A history of substance abuse or dependency in the last 12 months, or a history of recreational intravenous drug use over the last 5 years, or a positive toxicology screening panel (urine test including qualitative identification of barbiturates, THC, amphetamines, methamphetamines, MDMA, phencyclidine, benzodiazepines, opiates and cocaine), or alcohol breath test. Current or previous use of tobacco, nicotine products, vaping device or e-cigarettes within the past 6 months. Loss of more than 400 mL blood (e.g., as a blood donor, or donor of blood products), during the 3 months before screening. Received any vaccination (e.g. for COVID-19 or influenza) within 6 weeks of treatment or plans to receive a vaccination during the study. History of Mycobacterium tuberculosis infection, or latent M. tuberculosis infection. Active or latent parasitic infection, have travelled to or have an intention to travel to a country with a high prevalence of parasitic infections within 3 months before or after receiving the treatment. Evidence of any other clinically significant infection, including bacterial or viral infections, at Screening and Day -1. Presence of any underlying physical and/or psychological medical condition that would make it unlikely that the participant will comply with the protocol or complete the study per protocol. An employee of the study site or Sponsor who is directly involved in the study, or a family member of such a person.