Inclusion Criteria:  Extra-abdominal desmoid tumors (trunk and limbs), without limits related to gender. Histologic diagnosis confirmed by the Pathologic Anatomy of our Institute. Desmoid tumor progressing after at least two lines of appropriate medical therapy [including tamoxifen, nonsteroidal anti-inflammatory drugs (NSAIDs), or chemotherapy], with functional symptoms and/or pain; unresectable tumor or tumor amenable only to mutilating surgery deemed inappropriate. Patients with stable disease, but with persistent functional disability or tumor-induced pain not controlled by appropriate pain therapy, Other criteria of inclusion are: age >18 years; tumor deemed accessible for cryotherapy procedure by the interventional radiologist (with 90% of the tumor treatable by a cryoablation procedure and with a possible second cryoablation procedure if necessary and if scheduled at study entry); measurable lesion (mRECIST 1.1) using contrast-enhanced MRI.  Exclusion Criteria:  Desmoid tumors of the abdominal wall. Contraindication to the procedure by the interventional radiologist in terms of tumor size, proximity to neurologic/vascular structures that make the procedure risky; contraindication to any form of sedation; contraindication to MRI or gadolinium injection [proven allergy, glomerular filtration rate (GFR)<30 mL/min, renal disease]; psychiatric disorders and adults under guardianship, pregnancy or lactation, or under judicial guardianship.