Inclusion Criteria:  Volunteer to participate and sign the informed consent in writing; Age: 18-75 years old; No gender limit; Unresectable hepatocellular carcinoma with clear pathological diagnosis or clinical diagnosis; Unresectable hepatocellular carcinoma patients who failed first-line treatment (including but not limited to sorafenib, lenvatinib, atezolizumab combined with bevacizumab, etc.); At least one measurable lesion (according to mRECIST criteria) imaging diagnosis time ≤ 21 days from selection; Child-pugh grade A-B7 grade The expected survival period is ≥3 months; General physical condition (ECOG) 0-2; Sufficient bone marrow hematopoietic function (within 7 days): hemoglobin ≥9 g/dL, white blood cells ≥3.0×10^9/L, neutrophils ≥1.5x 10^9/L, platelets ≥80x 10^9/L; liver and kidney functions are normal; (Within 14 days): TBIL≤1.5 times the upper limit of normal; ALT and AST≤5 times the upper limit of normal; creatinine≤1.5 times the upper limit of normal; INR≤1.7 or prolonged PT≤4s.  Exclusion Criteria:  Those who are currently receiving other effective treatments; Patients who have received regorafenib in the past; Patients who have participated in other clinical trials within 4 weeks before enrollment; Unable to cooperate with cTACE and HAIC treatment; Patients with primary malignant tumors other than hepatocellular carcinoma at the same time, except for cured skin basal cell carcinoma and cervical carcinoma in situ; Clinically significant cardiovascular diseases, such as heart failure (NYHA III-IV), uncontrolled coronary heart disease, cardiomyopathy, arrhythmia, uncontrolled hypertension or a history of myocardial infarction within the past 1 year; Neurological or mental abnormalities that affect cognitive ability, including central nervous system transfer; There were active serious clinical infections (>grade 2 NCI-CTCAE version 4.0), including active tuberculosis within 14 days before enrollment; Known or self-reported HIV infection; Uncontrolled systemic diseases, such as poorly controlled diabetes; Known to have hypersensitivity or allergic reactions to any component of the study drug; Pregnancy (determined by serum β-chorionic gonadotropin test) or breast-feeding