Inclusion Criteria:  Age is between 20 and 80 years. Patients meeting the diagnosis of sepsis-associated brain injury. Patients who agreed to accept this trial and signed the informed consent form.  Exclusion Criteria:  Patients with a history of brain injury, stroke, epilepsy, cognitive impairment, or mental illness prior to admission. Patients who were also involved in any other interventional study. Due to hearing or vision loss, or any other situation that may seriously interfere with study data collection. Patients who refused to participate in this study. The pregnancy test was positive or is currently breastfeeding. Any other situation that the investigator believed might be detrimental to participant in the study.