Inclusion Criteria:  diagnosis of diagnosis of Stage I-III breast cancer (<10 years from diagnosis) episode of major depressive disorder without psychotic features on Structured Clinical Interview for DSM-5 (SCID-5) 24-item Hamilton Depression Rating Scale score ≥18 written informed consent  Exclusion Criteria:  Psychosis (by SCID-5 interview) current moderate/severe substance use disorder (mild substance disorder is not an exclusion) acute suicidal risk history of non-response to (>6 week) trials of venlafaxine (≥225 mg/d) and escitalopram (≥20 mg/d); history of non-response to IPT (>4 sessions receiving current medication or psychotherapy treatment for depression acute medical instability (too physically debilitated to participate in trial) or delirium inability to complete self-administered questionnaires in English current enrollment in a therapeutic oncology trial known metastases