Inclusion Criteria:  18 years old or older; Confirmed positive diagnosis of disease, condition or disorder. This will be self-reported or reported by the patient's provider, advocacy group or other patient representative; Laboratory or other independent means of confirmation is not required but may be confirmed in clinical trials; Able to understand and willing to sign the informed consent document; or whose legal representative has given consent to participate in the research per state and Federal requirements; Willing and able to complete the registry questions or have the instrument(s) completed by an informed proxy; Anticipated additional follow up with the registry once per year.  Exclusion Criteria:  Subjects who do not meet the inclusion criteria for the study; Subjects who are unable to understand the protocol or unable to provide legally effective informed consent