Inclusion Criteria:  Patients with confirmed thrombotic microangiopathy (TMA) based on citrated blood samples meeting both of the following criteria:  Thrombocytopenia [drop in platelet count ≥50% or platelet count < 100x109/L and Microangiopathic haemolytic anaemia (elevation of lactate dehydrogenase (LDH) >2- fold or by presence or increase of schistocytes in peripheral blood smear) Patients that voluntarily sign informed consent. For subjects unable to provide consent, a fully recognized medical proxy may be used according to local laws. Patients between 0 to 99 years old at the time of screening.  Exclusion Criteria:  -