Inclusion Criteria:  The patient is male or female 18 years of age or older The patient or legal representative has voluntarily signed and dated an Institutional Review Board (IRB)/Independent Ethics Committee (IEC) approved written informed consent. Female patients must be of non-childbearing potential (surgically sterile or post-menopausal for at least 1 year) or be practicing a highly effective contraception method from consent to at least 30 days after the last dose of study medication. Highly effective contraception methods include: vasectomized partner (at least 6 months prior to dosing); double barrier (diaphragm with spermicide; condoms with spermicide); intrauterine device; implanted or intrauterine hormonal contraceptives in use for at least 6 consecutive months prior to study dosing and throughout the study duration; oral, patch, or injected contraceptives in use for at least 3 consecutive months prior to study dosing. Male patients will be required to practice highly effective contraception methods such as: having had a vasectomy, double barrier (condoms with spermicide) or abstinence. Female patients of childbearing potential have a negative pregnancy test (serum β human chorionic gonadotropin [HCG]) during screening and ≤ 24 hours prior to dosing and are not lactating. Histologically confirmed solid malignant tumors, which are suspected to over express COX-2 by elevations in urinary PGE-M, such as, but not limited to colorectal, non-small cell lung cancer, head and neck, etc. Patients who (1) have failed all standard of care therapy (relapsed/refractory) or (2) have relapsed and are not a candidate for an available standard of care therapy as assessed by the investigator. Elevated urinary PGE-M levels at least 1.5 times the upper normal limits (Males 10.4+1.5, Females 6.0+0.7 ng/mg creatinine). Eastern Cooperative Oncology Group (ECOG) performance status 0, 1, or 2 and able to comply with protocol. Patients with treated brain metastases are eligible if there is no evidence of progression for at least 2 weeks after CNS-directed treatment, as ascertained by clinical examination and brain imaging during the screening period. Life Expectancy ≥ 12 weeks.  Normal organ function as defined below:  platelets ≥100,000/mcL total bilirubin ≤1.5X the institutional upper limit of normal (ULN) AST(SGOT)/ALT(SGPT) <2.5X institutional ULN or <5X institutional ULN in the presence of liver metastases creatinine clearance ≥45 mL/min/1.73 m2 for subjects with creatinine levels above institutional normal (use Cockcroft-Gault formula) absolute neutrophil count ≥1,500/mcL. No prior history of myocardial infarction, angina pectoris, coronary artery bypass graft (CABG) within 6 months prior to starting study treatment No congestive heart failure, clinically significant cardiac arrhythmias, complete left bundle branch block, high-grade AV block, left ventricular ejection fraction <50% evaluated by ECHO or MUGA requiring treatment. No increased QTCF (>450 for men and >470 for women). No NSAIDS, full dose oral anticoagulation such as warfarin within 2 weeks of screening. No gastric acid-reducing agents. Avoid strong inhibitors or inducers of CYP450 The patient is willing and able to understand the study procedures and to comply with the study protocol.  Exclusion Criteria:  Receiving other investigational drugs or participated in a clinical investigation trial of an agent within 30-days prior to or washout of at least 5 half-lives of the investigational drug prior to Day 1 (dosing of ECP-1014), whichever is longest. Patients with known hypersensitivity to COX-2, aspirin, or other NSAIDs, history of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. And those with history of allergic-type reactions to sulfonamides. Significant gastrointestinal abnormalities that may affect absorption (e.g., gastric bypass, short gut syndrome). History of gastric ulcer or gastrointestinal bleed. Known human immunodeficiency virus (HIV), acute or chronic hepatitis B virus surface antigen or (HBsAg) hepatitis C virus (HCV). Ongoing ≥ CTCAE grade 2 toxicity (except alopecia) due to prior cancer therapy. Patient has a condition that precludes ability to consume study medication. Concomitant disease or condition that, in the clinical judgment of the treating physician, is likely to prevent the subject from complying with any aspect of the protocol or that may put the subject at unacceptable risk.