Inclusion Criteria:  21-60 years of age Able to provide consent Heavy drinker, defined as drinking 5 or more drinks (4 or more drinks for women) on the same occasion on at least 5 days/month over the past 3 months Regular legal-market cannabis smoker, defined as using smoked flower cannabis obtained from a dispensary at least 3 days per week/over the past 3 months Willing to abstain from cannabis use for 14 days  Exclusion Criteria:  Daily tobacco use Actively seeking treatment for Alcohol Use Disorder or other Substance Use Disorder Females cannot be pregnant, breastfeeding or trying to become pregnant Meet criteria for psychotic, bipolar, or major depressive disorder with suicidal ideation, or history of these disorders Immune-relevant disease (e.g. osteoarthritis, HIV, cancer, recent infection, other autoimmune disorder) or currently taking an immune-modulating medication Current use of psychotropic (except anti-depressants or steroid-based medications) Report illicit drug use in the past 60-days or fail drug screen Major medical condition that contraindicates the consumption of alcohol or cannabis Use of an antibiotic medication in the past 3 months Current GI disorder including: inflammatory bowel disease, irritable bowel disease, diverticular disease, peptic ulcer/gastritis, and gastroesophageal reflux disease Use of probiotic or supplement drink at least once per week over the last 3 months