Inclusion Criteria:  Male of female, aged 18 to 60, inclusive No clinically relevant abnormalities identified by a detailed medical history and vital signs Presence of one keloid scar, up to 2.2 cm length and up to 1.2 cm width, at least 1 year from formation, and located on trunk or arms Willing to undergo surgical excision of keloid No concurrent treatment of the study keloid or prior treatment within last 2 months  Exclusion Criteria:  Prior keloidectomy of study keloid History of genetic disorder that predisposes to keloids (e.g., Ehlers-Danlos syndrome, Ullrich congenital muscular dystrophy, etc.) Corticosteroids (topical, injectable, inhalable, intranasal, or oral) within last two months (except as prescribed by physician for seasonal allergies) Clinically relevant cardiovascular, endocrine, hepatic, neurologic, renal, or other major systemic disease that could complicate execution of the protocol or interpretation of the study results History of thrombotic events, hemorrhagic events, and gastrointestinal perforation and fistula Subject has active collagen vascular disease or vasculitis, e.g., systemic lupus erythematosus, polyarthritis, dermatomyositis, systemic scleroderma or thrombotic thrombocytopenic purpura