Inclusion Criteria:  >18 y of age; acute onset of focal neurological deficit consistent with acute ischemic stroke; measurable neurological deficit (NIHSS ≥ 5); anterior-circulation ischemic stroke defined by magnetic resonance angiography (MRA) and Diffusion-Weighted Imaging(DWI); onset of symptom to admission more than 4.5 h and less than 72 h. Patients who arrived within 0-4.5 h poststroke were treated with other medications according to the best accepted medical treatment guidelines.  Exclusion Criteria:  Other diseases of the central nervous system There has been neurological disability in the past (mRS score>2) Difficulty swallowing Arrhythmia, atrioventricular block Use of anti-tumor drugs, other immunosuppressive and immunomodulatory drugs Macular edema MRA shows vertebral basilar artery obstruction Hemorrhagic stroke Patients who are known to have hypersensitivity to dimethyl fumarate or any excipients of this product Pregnant and lactating women