Inclusion Criteria:  Mono-infection with P. falciparum detected by microscopy. Parasitemia of 1.000-200.000/µl asexual forms. Axillary temperature ≥37.5 ˚C or a history of fever within 24 hours. Ability to swallow oral medication. Ability and willingness to comply with the study protocol for the duration of the study and to comply with the study visit schedule. Informed consent  Exclusion Criteria:  Signs or symptoms of severe malaria Presence of general danger signs in children under 5 Presence of severe malnutrition. Any evidence of chronic disease or acute infection other than malaria. Regular medication which may interfere with antimalarial pharmacokinetics. History of hypersensitivity reactions or contraindications to AL, DP or quinine. Domicile outside the study area.