Key Inclusion Criteria:  Visual acuity 20/25 to 20/40  o Epiretinal membrane (ERM) must be thought to be the primary cause of vision loss  ERM meeting the following criteria  Symptoms of visual loss and/or distortion (and in the opinion of the investigator, the ERM is contributing to the participant's symptoms); either new or worsening in the past 24 months Epiretinal membrane involving or altering the central 3 mm of the macula on optical coherence tomography (OCT) Distortion of the foveal center by ERM on OCT Immediate vitrectomy not required (investigator and participant are willing to wait at least 4 weeks to see if vision remains stable without having to proceed to vitrectomy) No known medical problems that will be a contraindication to surgery  Key Exclusion Criteria:  Secondary ERM due to retinal vascular disease, vitreous hemorrhage, retinal detachment, inflammatory disease, or associations other than vitreous syneresis, retinal break, or posterior vitreous detachment Prior intraocular surgery (except uncomplicated cataract extraction) Cataract extraction within prior 3 months History of diabetic macular edema (DME), retinal vein occlusion (RVO), or uveitis Past or current macular hole or degenerative lamellar macular hole Vitreomacular traction within 1,500 microns of the foveal center Central serous chorioretinopathy Nonproliferative diabetic retinopathy or worse (diabetic retinopathy severity >20)