Inclusion Criteria:  Male and Female subjects >18 years old. Patients undergoing clinically indicated non-emergent PCI as a stand-alone procedure or in combination with diagnostic angiography during the same procedure. Study target lesion characteristics: a) native de-novo coronary stenosis of at least 70% visually estimated stenosis, or at least 50% visually estimated stenosis and shown to be physiologically significant by flow-mediated criteria (FFR <0.80, IFR <0.91); b) estimated reference vessel diameter 2.0-4.5mm; c) lesion length <25mm; d) calcification not greater than mild. Per investigator assessment, the patient may benefit from inflation distal perfusion during balloon inflation. Examples include, but are not limited to: (i) LV systolic dysfunction with LVEF<50% by any modality; (ii) a territory subtended by the target vessel downstream from the target lesion that is estimated to be in excess of 25% of viable LV mass; (iii) prior hemodynamic or electrical instablility during intervention on the target lesion; (iv) the potential to avoid placement of a coronary stent if a stent-like result can be achieved through prolonged balloon inflation. Female subjects of childbearing potential must have a negative pregnancy test per standard of care for PCI and be practicing contraception. Informed consent provided.  Exclusion Criteria:  Hemodynamic or arrhythmic instability within 48 hours or a myocardial infarction within 72 hours of PCI. More than 2 lesions planned during index PCI. Procedural complication developing prior to PCI of study target. Ejection fraction (EF) <25%. Creatinine clearance (Cr-Cl) <25 mg/dL. Baseline flow at study target <TIMI-2.