Inclusion Criteria:  Patients with chronic liver disease caused by virus C. Have received treatment with the new DAAs between November 1, 2014 and December 1, 2017. Patients diagnosed with advanced fibrosis and liver cirrhosis. Advanced fibrosis was defined as a Fibroscan> 10 kPa, an APRI index> 1.5 and / or a FIB-4 index> 3.25. For its part, cirrhosis was defined such as a Fibroscan> 12.5 kPa and / or presence of esophagogastric varices in the endoscopic study and / or data portal hypertension ultrasound.  Exclusion Criteria:  Coinfection by virus B or HIV. Development of HCC before or during treatment. Abuse of alcohol intake or addiction to parenteral drugs. Liver disease of non-viral etiology (autoimmune, toxic, metabolic).