Inclusion Criteria:  Patients aged > 18 years Willingness to participate in this study including the assessment with high resolution OCT Skin lesion/tumor with suspicion for skin cancer that requires skin biopsy or complete excision Benign skin tumor that is scheduled for excision due to suspicion, irritation or for cosmetic reason  Exclusion Criteria:  Patients aged < 18 years Any unstable medical or psychological conditions Unwillingness to participate in this study including the assessment with high resolution OCT