Inclusion Criteria:  Subjects must give written informed consent, and Subject is ≥ 18 years of age, and Subject is eligible for a kidney or simulateous kidney pancreas transplant, and Subjects are highly sensitized (cPRA 98-100%), and Subjects have a positive T flow crossmatch  Exclusion Criteria:  Severe cardiac disease not amenable to intervention Clinical significant systemic infection within 30 days prior to transplant Life expectancy < 1 Year Positive pregnancy test performed < 1 week prior to enrollment or intention to plan a pregnancy in the following year Current drug or alcohol abuse Uncontrolled, severe psychiatric illness Combined transplantation of kidney and other organs