Inclusion criteria  Patient admitted to the intensive care unit Severe infection in any site (defined as the presence of sepsis/septic shock or bloodstream infection) associated with a positive culture by MRD-GNB (Acinetobacter baumannii complex, Pseudomonas aeruginosa, and Enterobacterales bacteria, only susceptible to carbapenems and/or polymyxins) Hemodynamically stable and afebrile (axillary temperature less than 37.8ºC) for at least 48 hours on day 7 of adequate antibiotic therapy  Exclusion criteria  Inclusion in other experimental studies involving antimicrobial therapy Infections that have as the primary site: endocarditis/endovascular infection, necrotizing fasciitis, osteomyelitis, abdominal abscess or other abdominal infections requiring surgical intervention, central nervous system infections, empyema, prosthetic infection Immunosuppression defined as: neutrophil cells <1000/mm³ in the current hospitalization, HIV/AIDS diagnosis with last CD4 count <200/mm³, solid organ transplantation in the last year and/or need for increased immunosuppression due to acute rejection in the last year, hematopoietic stem cell transplantation in the last year, and/or current therapy for chronic graft-versus-host disease Positive blood cultures for the same pathogen within 48 hours prior to randomization, when collected Concomitant infection with another GNB (regardless of susceptibility profile) Previous inclusion in this study Known pregnancy