Inclusion Criteria:  Age>=18Y Good Organ Function Expected survival time ≥ 3 months advanced melanoma with BRAF V600 mutation that have been diagnosed ECOG score 0-1;  Exclusion Criteria:  Previous treatment with BRAF inhibitors or MEK inhibitors Symptomatic brain or meningeal metastases (unless the patient has beenon > treatment for 3 months, has no evidence of progress on imagingwithin 4 weeks prior to initial administration, and tumor-related clinicalsymptoms are stable). Severe active infections requiring systemic anti-infective therapy A history of other malignancies within two years, except for cured carcinoma in situ of the cervix or basal cell carcinoma of the skin.