Inclusion Criteria:  Adult over 18 years old The vaccinated patients to be included must have received a complete vaccination scheme for COVID-19 according to the Ministerio de Salud y Protección Social de Colombia SARS-CoV-2 infection in the last 2 months, verified by rtPCR test  Exclusion Criteria:  Immunocompromised patients Immunosuppressive treatments, chemotherapy or antiretroviral therapy Outpatient anticoagulant therapy For vaccinated people (groups 1 and 2): if have had COVID-19 infection in the last 6 months