Inclusion Criteria:  DBS in one of the defined nuclei of interest during the period of the study Male or female, aged 18 years and above Be willing and able to give written and oral informed consent Ability to complete all required study procedures including travelling to Mayo Clinic and staying overnight All women of childbearing potential and women who have been amenorrheic for less than 1 year must practice effective contraception during the study. This includes a barrier method such as condom or diaphragm with spermicide; barrier intrauterine device (IUD) or abstinence.  Exclusion Criteria:  Cognitive impairment (judged by the clinician taking consent as not having sufficient mental capacity to understand the study and its requirements). This is including anyone who, in the opinion of the clinician taking consent is unlikely to retain sufficient mental capacity for the duration of their involvement in the study. Patients with any other medical condition that would interfere with study conduct or make it unsafe for them to participate Pregnancy test positive.