Inclusion Criteria:  Patients with COPD who treated in Phramongkutklao Hospital Have a history of smoking FEV1 predicted after bronchodilator more than 50% No change in medication in 4 weeks No history of acute exacerbation in 4 weeks No history of cardiac disease.  Exclusion Criteria:  Recurrent of acute exacerbation Cannot participate at least 80% of training program (≤ 32 sessions of 40 sessions) Unwilling to continue practicing.