Inclusion Criteria:  Male or female, 18 years of age or older Dental panoramic radiograph or cone beam examination less than 6 months prior to inclusion  Clinical criteria and similar radiographs of the 2 mandibular third molars:  Stage of root planing Normoposition, horizontal Type of eruption: disincluded, impacted, impacted Anatomical relationship between inferior alveolar nerve and mandibular wisdom tooth apices similar for both sides Affiliation to a social security scheme Informed consent, dated and signed before any study procedure is performed  Exclusion Criteria:  Pregnant or breastfeeding woman Known allergy to the anesthetic molecule or to a component of the anesthetic carpule Contraindication to the use of vasoconstrictor in dental anesthesia Contraindication to a therapeutic procedure under local anesthesia Patients taking TKA for another medical reason Presence of a cystic pathology related to at least 1 of the 2 mandibular third molars to be extracted Limitation of mouth opening Associated systemic pathology requiring priority management Inability of the patient to comply with study follow-up and scheduled visits (especially for second wisdom tooth avulsion) Patient under legal protection