Inclusion Criteria:  Adult male or female (age ≥ 18 years); Patient requiring root canal treatment or retreatment; Patient who will need a single visit for the root canal therapy, for a mature molar or second premolar, with or without pre-operative pain Patient who received information and gave written consent (signed informed consent form); Subject affiliated to a health insurance system, or is a beneficiary (art. L.1121-11, Code of Public Health, France).  Exclusion Criteria:  Pulpotomy or pulpectomy performed at a prior visit; Tooth with apical calcification (sealer unable to reach the root apex); Tooth with suspected root perforation; Immature tooth (too wide root apex requiring an apexification); Other dental treatment ongoing or scheduled within the study period; At least one symptomatic tooth among those that are not included in this study Known hypersensitivity to steroids, local anesthetics, or any component of study medical devices; Subject using long term anti-inflammatory drugs; Use of illicit substances during the 48h before the first visit (cannabis, cocaine…); Presence of any significant medical finding or significant history such as uncontrolled systemic diseases that may impact the safety, the interpretation of the results and/or the participation of the subject in the study according to the opinion of the investigator; Subject who cannot be contacted in case of emergency (phone number); Simultaneous participation in another clinical trial or subject still within the exclusion period of a previous clinical trial; Vulnerable subjects (art. L.1121-5 and L.1122-1-2, Code of Public Health, France; art. 66 of the Regulation (EU) 2017/745 on medical devices)