Inclusion Criteria:  Age 70 or more Undergoing major non cardiac surgery Expected surgical duration > 2 hours.  Exclusion Criteria:  Patients unable to express consent Patients undergoing urgent/emergent surgery Patients in which surgery is planned within less than two weeks Patients with limited physical activity due to limited mobility related with neurological or orthopedic disease Acute cardiovascular event Surgery conducted in locoregional anesthesia only