Inclusion Criteria:  Patient scheduled for TAVR through femoral artery access 1h ≤ Expected duration of surgery ≤ 3h Planned for general anesthesia without intubation 18 ≤ BMI ≤ 30 ASA category Ⅱ～Ⅳ  Exclusion Criteria:  Contraindications to anesthesia/sedation or a history of adverse reaction to anesthesia/sedation Known allergies to eggs, soy products, opioids and their antidotes, propofol, etc; Contraindications of propofol, opioids and their antidotes Shock and hypotension difficult that is to be corrected by vasoactive drugs in the screening period Hemoglobin (HB) < 10.0 g / dl (100 g / L) Judged by the investigator to have any other factors that make the subject unsuitable for participation in the study.