Inclusion Criteria:  Average office BP ≥140/90 mmHg at screening visit despite taking stables doses of three or more antihypertensive medications, including a diuretic, for at least 4 weeks prior to consent Documented daytime ABP ≥135/85 mmHg following 4 week stabilization period on on standardized antihypertensive medication regimen  Exclusion Criteria:  Renal artery anatomy ineligible for treatment Secondary hypertension not including sleep apnea Type I diabetes mellitus or uncontrolled Type II diabetes (defined as plasma HbA1c ≥9.0%) eGFR <40 Brachial circumference ≥42 cm Any history of cerebrovascular event or severe cardiovascular event within 3 months prior to consent Documented repeat (>1) hospitalization for hypertensive crisis within 3 months prior to consent Documented confirmed episode(s) of unstable angina within 3 months prior to consent Chronic oxygen support or mechanical ventilation other than nocturnal respiratory support for sleep apnea Primary pulmonary hypertension Night shift workers Pregnant, nursing or planning to become pregnant