Inclusion Criteria:  Patients aged 18-65 years, of either gender with the clinical diagnosis of major depressive disorder (DSM 5). Patients with MADRS score ≥ 7 and ≤ 34 (Mild to moderate severity). Patients who are on a stable dose of Sertraline 50 mg or any other SSRI (selective serotonin reuptake inhibitor) therapy in equivalent dose. Patients who have given informed written consent.  Exclusion Criteria:  Major depressive patient treated with Electro Convulsive Therapy recently. History of epilepsy, head trauma, or other major neurological or medical disorders. Patients with a history of bipolar depression. Patients with schizophrenia or other psychotic disorder. Patients with suicidal risk. Patients with cognitive impairment. Initiating or stopping formal psychotherapy within six weeks before enrolment. Patients with comorbidities like any malignancies, hepatic, renal, cardiovascular, neurological or endocrinal, respiratory dysfunction. Substance abuse history of psychoactive agents. Pregnant and lactating mothers.