Inclusion Criteria:  Patients with a ≥20mm colon non-pedunculated polyp who are undergoing an ESD or EMR resection signed Informed Consent  Exclusion Criteria:  Patients with known (biopsy proven) or strongly suspected invasive carcinoma in a potential study polyp Pedunculated polyps (as defined by Paris Classification type Ip or Isp) ulcerated depressed lesions (as defined by Paris Classification type III) polyposis syndromes inflammatory bowel disease emergency colonoscopy Poor general health (ASA (American Society of Anaesthesiologists) class>3) Patients with coagulopathy with an elevated INR (International Normalized Ratio) ≥1.5, or platelets <50 Poor bowel preparation pregnancy or breastfeeding Intervention planned using ORISE™ (Boston Medical) or LIFTUP™ (Ovesco) as lifting agents