Inclusion Criteria:  Healthy males or females within the ages of 21 to 65 years, inclusive. Subjects will have a body mass index (BMI) of 18.5 to 35.0 kg/m2, inclusive, and a body weight exceeding 52 kg (males) or 45 kg (females). Subjects must be current smokers (≥10 per day) of factory-made, high tar (10mg) combustible cigarettes (eCO >10 ppm at screening) for at least one continuous year before Visit 1 and may be occasional or dual users of e-cigarettes. Urine cotinine >200 ng/mL. Subject demonstrates understanding of the study and willingness/consent to participate as evidenced by voluntary written informed consent and has received a signed and dated copy of the consent form. Subject understands and is willing, able, and likely to comply with all the study procedures and restrictions. Subject is in good general health in the opinion of the investigator, with no clinically significant and relevant abnormalities of medical history (e.g., uncontrolled hypertension, recent myocardial infarction or unstable angina, history of seizures or recent stomach ulcer). Subject has a seated systolic blood pressure ≤160 mmHg, diastolic blood pressure ≤95 mmHg, and heart rate ≤100 bpm. Females of childbearing potential are, in the opinion of the investigator, practicing a reliable method of contraception.  Exclusion Criteria:  Subjects who, in the judgment of the study physician, have recent or active COVID 19 infection, as evidenced by the following:  Endorsement of symptoms that could indicate COVID-19 during screening (Section 13.1) and/or Body temperature ≥38.0°C and/or Laboratory test results suggestive of active or recent exposure to SARS-CoV-2 (Section 9.4). Laboratory serology results positive for HBsAg, hepatitis C virus (HCV) antibody, (HIV) type 1 or 2. Subjects who have participated in another clinical study within 30 days of Visit 1 or who have previously participated in this study. Subjects who have an acute illness (e.g., upper respiratory tract infection, viral infection) requiring treatment in the 4 weeks prior to Visit 1, or an active respiratory infection at time of the Screening Visit. Subject has a clinically significant abnormal finding on the physical examination, medical history, vital signs, ECG, lung x-ray or clinical laboratory results that could interfere with, or for which use of the study products might interfere with, the conduct of the study, or that would, in the opinion of the investigator, pose an unacceptable risk to the subject in this study. Subjects who have used any nicotine or tobacco product other than e-cigarettes or factory-made combustible cigarettes in the 14 days prior to the Visit 1. Subjects who are self-reported or observed (during the trial session at Visit 2) non inhalers during ENDS/cigarette use. Subjects who have used any prescription or over-the-counter (OTC) smoking cessation treatments, including, but not limited to any form of nicotine replacement therapy (NRT), varenicline, cytisine, or bupropion within 30 days prior to Visit 1. Is planning to quit smoking during the study or postponing a quit attempt in order to participate in the study. Subjects who have used prescription or OTC bronchodilator medication (e.g., inhaled or oral β adrenergic agonists, anticholinergics, glucocorticoids, cromones, or theophylline) to treat a chronic condition within the 12 months prior to Visit 1 or have a history of lung disease. Subjects who have received any medications or substances that interfere with the cyclooxygenase pathway within 14 days prior to Visit 1 or are known to be strong inducers or inhibitors of cytochrome P450 (CYP) enzymes within 14 days or 5 half lives of the drug (whichever is longer) prior to Visit 1. Women who are pregnant or who have a positive urine pregnancy test. Women who are breast-feeding. Subject has a history or diagnosis of adult asthma, COPD (including emphysema and chronic bronchitis), or use of an inhaler within the past 3 months. Subject has been hospitalized in the 28 days prior to the Visit 1. Subject has a history of schizophrenia, psychosis, or bipolar disorder. Subject provides a positive drugs of abuse urine test at Visit 1. Tested drugs will include cocaine, amphetamines, methamphetamines, opiates (morphine, heroin), barbiturates, and benzodiazepine. Subject has a self-reported use of more than 21 drinks per week. A drink is defined as 25 ml of spirits (e.g., whisky, vodka), 250 ml of beer, or 75 ml of wine. Subjects who have lost or donated more than 450 mL of blood within the 2 months preceding the first product use. Subject is an employee of the sponsor or the study site, or members of their immediate family. In the opinion of the investigator, the subject should not participate in this study. A history of allergy/oversensitivity to the ingredients of the study products.