Inclusion Criteria:  Diagnosis of asthma step 4 to 5 under optimal medical treatment for at least 6 months according to GINA guideline Symptomatic despite being on treatment: Asthma Control Test (ACT) score ≥ 20 ≤24 Able to perform and complete with studies procedures (FeNO, CPET, Six Minute Walking Test (6MWT), MVS.  Exclusion Criteria:  Diagnosis of Chronic Obstructive Pulmonary Disease (COPD) according to the Global initiative for Obstructive Lung Disease (GOLD) guidelines criteria Smokers or ex-smokers with pack/years ≥10 Body Mass Index (BMI) ≥30 Change in asthma medications in the last 30 days Cognitive impairment (Mini-Mental State Examination score <22) History of oncological, neurological, cardiovascular diseases, musculoskeletal impairment and/or medical diseases precluding exercise testing and pulmonary rehabilitation