Inclusion Criteria:  Be a male or female 18 years of age or older. For females: Be of non-childbearing potential or willing to use appropriate contraceptive measures for 30 days prior to vaccination through 6 months after completion of the vaccine series. Willingness to provide a signed, printed, and dated informed consent form. Able and willing to participate in all activities in the clinical trial. Participants with HIV, HBV, HCV should have a health record, determined to be stable for 6 months prior to the screening.  Exclusion Criteria:  Participants with unstable pre-existing medical conditions over the three months before enrollment (condition that has worsened to require hospitalization or significant changes in therapy). Planned administration/administration of a vaccine not foreseen by the study protocol from within 45 days before the first dose of study vaccine. Previous vaccination with any Covid-19 vaccine. History of COVID-19 disease. History of allergic reactions or anaphylaxis to previous immunizations or allergies to any components of the vaccine. Planning to become pregnant or planning to discontinue contraceptive precautions during the vaccination phase through 6 months after the second immunization. History of bleeding disorders/hemostasis or use of anticoagulants. Currently having cancer or undergoing cancer treatment. Chronic administration (defined as more than 14 days) of immunosuppressants or other immune-modifying drugs within 3 months prior to the first vaccine dose (inhaled and topical steroids are allowed). Women who are pregnant or breastfeeding.