Inclusion Criteria:  1. The patients volunteered to participate in this study and signed the informed consent; 2. Pathologically confirmed as a newly diagnosed and unresectable locally advanced non-small cell lung cancer (STAGE IIIA/ IIIB) with measurable lesions;IIIa3: Multistation lymph node metastases detected by mediastinoscopy, other lymph node biopsy, or PET/CT;IIIa4: Massive or fixed multistation N2 lymph node metastasis (massive lymph nodes, defined as lymph nodes with a short diameter of more than 2 cm on a helical CT scan, especially those with extranode invasion).;Patients with IIIb.In addition, T3/4 with multiple satellite nodules in the ipsilateral or contralateral lung was not included in this study. 3. Patients with negative EGFR, ALK and ROS1 gene test results; 4. Ages 18-75, regardless of gender; 5. ECOG score: 0-1; 6. Expected survival over 3 months; 7. Function of major organs within 7 days prior to treatment meets the following criteria:  A. Standard of blood routine examination (without blood transfusion within 14 days) :  I. Hemoglobin (HB) ≥100 g/L; II. WBC ≥3.0×109/L; Iii. Platelet (PLT) ≥100×109/L.  B. Biochemical examination shall meet the following standards:  I. Total bilirubin (TBIL) ≤1.5 times the upper limit of normal value (ULN); II. AST≤2.5×ULN of alanine aminotransferase (ALT) and aspartate aminotransferase (ASpartate), if accompanied by liver metastasis, ALT and AST≤5×ULN; III. Serum creatinine (Cr) ≤1.5×ULN or creatinine clearance rate (CCr)≥60ml/min; C. Doppler ultrasound evaluation: left ventricular ejection fraction (LVEF) ≥ lower normal limit (50%); D. Pulmonary function assessment: FEV1≥1.45 l/s.  8. Patients of childbearing age (including female and female partners of male patients) must take effective birth control measures  Exclusion Criteria:  1. Patients who have previously used anlotinib hydrochloride capsules; 2. Small cell lung cancer (including mixed small cell and non-small cell cancers); 3. Lung squamous cell carcinoma with empty cavity, or non-small cell lung cancer with hemoptysis (> 20ml/day); 4. Patients with other malignant tumors other than NSCLC within 5 years before the start of treatment in this study (except those with simple surgical resection and disease-free survival for at least 5 consecutive years, cured cervical carcinoma in situ, cured basal cell carcinoma and bladder epithelial tumor); 5. Systemic antitumor therapy, including cytotoxic therapy, signal transduction inhibitors and immunotherapy, is planned within 4 weeks before enrollment or during the medication period of this study.In addition to thymosin, lentinan and other immunomodulator treatment. 6. Unmitigated toxicity due to any previous treatment above CTC AE level 1, excluding hair loss; 7. Patients with multiple factors affecting oral medication (such as inability to swallow, chronic diarrhea and intestinal obstruction); 8. Accompanied by pleural effusion or ascites, causing respiratory syndrome (≥CTC AE level 2 dyspnea); 9. Patients with any severe and/or uncontrolled disease, including: A) Patients with unsatisfactory blood pressure control (systolic blood pressure ≥150 mmHg, diastolic blood pressure ≥100 mmHg); B) Having grade I or above myocardial ischemia or infarction, arrhythmia (including QTc ≥480ms), and grade 2 or above congestive heart failure (New York Heart Association (NYHA) classification); C) Active or uncontrolled severe infection (≥CTC AE level 2 infection); D) Antiviral treatment for cirrhosis, decompensated liver disease, active hepatitis or chronic hepatitis; E) Renal failure requires hemodialysis or peritoneal dialysis; F) A history of immunodeficiency, including HIV positive or other acquired or congenital immunodeficiency diseases, or a history of organ transplantation; G) poor control of diabetes mellitus (FBG) > 10mmol/L; H) urine routine indicated urinary protein ≥++, and confirmed 24-hour quantitative urinary protein > 1.0g; I) patients with epileptic seizures requiring treatment; J) Patients with gastric ulcer 10. Receive major surgical treatment, open biopsy or significant traumatic injury within 28 days before grouping; 11. Patients whose tumors have invaded important blood vessels according to imaging findings or whose tumors are likely to invade important blood vessels during the follow-up study according to the judgment of the researchers, resulting in fatal massive hemorrhage; 12. Patients with any physical signs or history of bleeding, regardless of severity;Patients with any bleeding or bleeding event ≥CTCAE level 3 within 4 weeks prior to enrollment have unhealed wounds, ulcers or fractures; 13. Occurrence of ARTERIAL/venous thrombotic events, such as cerebrovascular accidents (including temporary ischemic attacks), deep venous thrombosis and pulmonary embolism within 6 months; 14. Persons with a history of abuse of psychotropic substances and who cannot be cured or have mental disorders; 15. Pregnant and lactating women; 16. Participated in other clinical trials of anti-tumor drugs within 4 weeks; 17. The researcher considered that there were other conditions that were not suitable for inclusion.