Inclusion Criteria:  18-65 years of age ADPKD diagnosis based on the modified Pei-Ravine criteria Body-mass index of 25-45 kg/m^2 Estimated glomerular filtration rate ≥ 30 mL/min/1.73m^2 Total kidney volume (htTKV) > 600 mL, calculated from a previous kidney ultrasound or magnetic resonance imaging performed within the last 12 months Access to the internet with video chat capabilities No plans for extended travel (>2 weeks) without internet access during the 12-month intensive period Not currently participating in another interventional study or weight loss program Ability to provide informed consent  Exclusion Criteria:  Diabetes mellitus Current smokers or history of smoking in the past 12 months Alcohol dependence or abuse History of hospitalization or major surgery within the last 3 months Untreated dyslipidemia Uncontrolled hypertension Pregnancy, lactation, or unwillingness to use adequate birth control Cardiovascular disease, peripheral vascular disease, or symptoms suggestive of cardiovascular disease: chest pain, shortness of breath at rest or with mild exertion, syncope Abnormal resting electrocardiogram (ECG): serious arrhythmias, including multifocal premature ventricular contractions (PVC's), frequent PVC's (defined as 10 or more per min), ventricular tachycardia (defined as runs of 3 or more successive PVC's), or sustained atrial tachyarrhythmia; 2nd or 3rd degree A-V block, QTc interval > 480 msec or other significant conduction defects Significant pulmonary disease including: chronic obstructive pulmonary disease, interstitial lung disease, cystic fibrosis, or uncontrolled asthma Regular use of prescription or over-the-counter medications that may affect weight, appetite, food intake, or energy metabolism History of clinically diagnosed eating disorder including: anorexia nervosa, bulimia, binge eating disorder Weight loss of >5% in the past 3 months for any reason except post-partum weight loss; weight gain >5% requires assessment by PI Major psychiatric disorder (e.g., psychosis, schizophrenia, mania, bipolar disorder) or current severe depression, based on DSM-IV-TR criteria for Major Depressive Episode, which in the opinion of the Study MD would interfere with ability to adhere to dietary interventions) Inability to cooperate with or clinical contraindication for magnetic resonance imaging, including: severe claustrophobia, implants, devices, or non-removable body piercings