Inclusion Criteria:  Has American Society of Anesthesiologists (ASA) Physical Status of I, II, or III. Is scheduled to undergo a unilateral Total Shoulder Arthroplasty (TSA) or abdominoplasty.  Exclusion Criteria:  Is undergoing a revision surgery. Has a known or suspected history of hypersensitivity or clinically significant idiosyncratic reaction to bupivacaine (or other local anesthetics), NSAIDs, acetaminophen, oxycodone, morphine, or hydromorphone. History of severe allergic reaction to aspirin or other NSAIDs, or known history of severe gastrointestinal adverse reactions associated with NSAID use Has taken meloxicam within 10 days prior to the scheduled surgery, or any NSAID within 24 hours prior to the scheduled surgery, with the exception of subjects on low-dose (≤100 mg) daily acetylsalicylic acid for cardioprotection Opioid use for most days within the last 3 months prior to Screening in the opinion of the Investigator. Has been administered immediate-release bupivacaine HCl within 5 days prior to the scheduled surgery, or a modified-release bupivacaine product within 14 days prior to the scheduled surgery. Has initiated treatment with any of the following medications within 1 month prior to study drug administration: selective serotonin reuptake inhibitors, selective norepinephrine reuptake inhibitors, gabapentin, pregabalin, duloxetine, or cyclooxygenase-2 inhibitors. Has been administered systemic steroids within 5 half-lives or 10 days prior to the scheduled surgery (whichever is longer). Has a known or suspected history of drug abuse, a positive drug screen (except for cannabinoids) on the day of surgery, or a history of alcohol abuse within the past 5 years. Suspected or confirmed active coronavirus disease 2019 (COVID-19) infection Had a malignancy in the last year, with the exception of nonmetastatic basal cell or squamous cell carcinoma of the skin or localized carcinoma in situ of the cervix. Has undergone 3 or more surgeries within 12 months, other than for diagnostic procedures (eg, colonoscopy). Has a body mass index (BMI) >40 kg/m2. Had undergone prior abdominoplasty or major abdominal wall surgery.