Inclusion Criteria:  High-grade intraepithelial neoplasia of the esophagus 18-80 years old The tumor was confined to the lamina propria of the mucosa The tumor invaded the submucosa and was limited to 200 microns  Exclusion Criteria:  The tumor invaded the entire circumference of the esophagus The tumor invaded the muscularis or submucosa more than 200 microns The patient has difficulty tolerating anesthesia due to other diseases Pregnant or breastfeeding women