Inclusion Criteria:  Written informed consent Males or females age ≥ 18 At least one venous chronic leg ulcer with the following condition 3.1. Ulcer is present beyond 2 months 3.2. Conservative treatment not leading to improvement 3.3. Wound size between ≥5 and ≤100 cm2 Ability to safely undergo tissue harvest that is anticipated to yield >100mL of adipose tissue at a site that is free from infection and injury Able and willing to work with the doctor, adhere to therapeutic prescriptions and appear on prescribed examinations Normal or clinically not significant abnormal values based on investigator judgement on white blood cell count (WBC), C-reactive protein (CRP), Platelets, international normalized ratio (INR), partial thromboplastin time (APTT), haemoglobin (Hgb), Renal and Liver function Females of childbearing potential must have a negative pregnancy test at the Screen Visit Females of childbearing potential must agree to use a highly effective method of birth control during the study. A highly effective method of birth control is defined as one which has a proven low failure rate of less than 1%  Exclusion Criteria:  More than 20% change in surface area of target ulcer between screening and enrollment visit. There is bone involvement in case of ulcer Patient with a history of bleeding disorder Therapy for anticoagulation Patient receiving corticosteroids, immunosuppressive or cytotoxic agents, and all systemic agents that can affect wound repair Patient with any treatment that might interfere with the assessment of the study treatment Pregnant or likely to become pregnant or lactating women Participation in any type of clinical investigation concurrently or in the last 6 months Positive for HIV, hepatitis B virus (HBV) or hepatitis C virus (HCV) and syphilis (results within 1 month are acceptable) Any concurrent disease or condition that, in the opinion of the investigator, would make the patient unsuitable for the participation in the study. Active cancer during chemotherapy or radiotherapy, or recent cancer, if the remission had place less than 5 years before joining the study (except basal cell skin cancer) Patient currently undergoing dialysis for renal insufficiency (serum creatinine ≥2 mg/dL) In the opinion of treating physician, patient not expected to survive beyond 30 days Subjects with psychiatric conditions that are anticipated to result in protocol noncompliance Uncontrolled chronic disease Patient with history of severe alcohol or drug abuse Lack of patient's cooperation Use with blood thinners within 8 weeks of enrollment  Systemic treatments with a possible effect on ulcers within 4 weeks prior to enrollment with the following exceptions:  Ustekinumab (within 16 weeks prior to enrollment) Adalimumab, infliximab, alefacept (within 8 weeks prior to enrollment)