Inclusion Criteria:  Patients with sepsis who meet the Sepsis 3.0 standard proposed by the 2016 International Sepsis Expert Consensus, that is, for patients with infection or suspected infection, when sepsis-related sequential organ failure (Sequential (Sepsis-related) Organ Failure) Assessment (SOFA) score increased by ≥ 2 points from the baseline can be diagnosed as sepsis; It is estimated that the patient's ICU stay ≥24 hours; Obtain informed consent and sign an informed consent form.  Exclusion Criteria:  The patient's ICU hospital stay is less than 24 hours; Participated in other clinical research; Failed to sign the informed consent form.