Inclusion Criteria:  FDG avid lesion in a clinically suspected case of lymphoma. Suspicious, residual FDG avid lesion detected at the time of follow-up PET/CT imaging in a patient with a prior diagnosis of lymphoma either at the end-of-treatment or during surveillance.  Exclusion Criteria:  Deranged coagulation profile. Inaccessibility of the lesion for a percutaneous biopsy. Resolution of the lesion at the time of biopsy planning. Participant is not willing for the procedure. Pregnant females and participants less than 18 years of age.