Inclusion Criteria:  For people living with HIV receiving two-dose regimen:  Females 9-26 years and males 9-14 years, Documented HIV infection, Aware of HIV+ status, Currently receiving antiretroviral treatment (ART) for HIV infection for at least six months, Living in Eswatini, For individuals 18+ years: able to provide informed consent, For individuals 15-17 years: able to provide informed assent, For individuals 9-14 years of age: able to provide informed assent AND accompanied by an adult caregiver who is able to give informed consent, Intending to remain in the vicinity of the study sites for the study period  For reference group of HIV-uninfected women receiving three-dose regimen:  Females 15-26 years, Documented negative HIV test at baseline Living in Eswatini, Able to provide informed assent (15-17 years) or informed consent (18-26 years) Intending to remain in the vicinity of the study sites for the study period  Exclusion Criteria:  For all participants:  Diagnosis of other immunosuppressive diseases or receipt of immunosuppressive medications, Diagnosis of other acute or chronic illness, Receipt of other vaccinations within 2-3 weeks before or after study vaccination, Receipt of blood-derived products within 6 months before or during the study, Previous receipt of an HPV vaccine, Currently pregnant, Known allergies to a vaccine component