Inclusion Criteria:  Healthy male subjects; 18 - 40 years of age Body mass index between 18 and 27 kg/m2 Written informed consent Normal findings in medical history Non-smoking  Exclusion Criteria:  Regular intake of any medication including OTC drugs and herbals within 2 weeks before IMP administration History of occlusive vascular diseases History of vascular anomalies History of coagulation disorders History of diabetes mellitus (Type 1&2) or pre-diabetes (i.e. HbA1c ≥ 5,7 %) History of kidney disease History of ketoacidosis Impaired liver function (AST, ALT, gGT, bilirubin >3 x ULN) Impaired renal function (serum creatinine > 1.3 mg/dl) Any other relevant deviation from the normal range in clinical chemistry, haematology or urine analysis HIV-1/2-Ab, HbsAg or HCV-Ab positive serology Systolic blood pressure above 145 mmHg, diastolic blood pressure above 95 mmHg Known allergy against any test agent under study and/or lactose intolerance Regular daily consumption of more than on litre of xanthine-containing beverages or more than 40g alcohol Participation in another clinical trial during the preceding 3 weeks