Inclusion Criteria:  Subjects with American Society of Anesthesiologists score I (ASA I) Subjects with Frankl's behavior rate III (positive) and IV (definitely positive), Subjects with indication of similar restoration treatment on bilateral first permanent mandibular molars Subjects whose plaque index score of 0 (no plaque) and 1 Subjects whose gingival index score of 0  Exclusion Criteria:  Allergic to the local anesthetics or sulfites Subjects with cholinesterase deficiency Subjects who use drugs that may affect the assessment of pain, such as narcotic or non-narcotic analgesic, anti-inflammatory, anxiolytic, antipsychotic and antihistamine agents Subjects who need to use sedatives or other medications during dental procedures