Inclusion Criteria:  Age group (18-38) History of at least 2 previous IVF or ICSI trial failures with ET of at least 2 good quality embryos in each trial. Endometrial cavity within normal anatomy as assessed with transvaginal ultrasound (TV-US) with or without hysteroscopy and HSG if needed. Availability of good quality embryos (at least 2 grade A embryos) for ET in the investigated trial  Exclusion Criteria:  Any factor which may affect quality of embryos transferred or endometrial receptivity and embryo growth, like:  Severe male factor infertility Poor ovarian reserve (according to ESHRE criteria) 1 Uterine anatomic factor (eg polyp, intramural fibroid, endometrial septum, intrauterine synechiae .. etc) as well as endometritis Immunological disorder (eg: SLE, APS, … etc) Thyroid or adrenal dysfunction Thrombophilia history or tendency as proven by labs in suspected women Untreated hyperprolactinemia Genetic abnormalities in the infertile couple Chronic hematologic, renal or liver disease