Inclusion Criteria:  Diagnosed with small intestinal CD Fecal calprotectin ≥ 250 ug/g IUS evidence of small bowel inflammation with wall thickness ≥ 4 mm At least 3 months af stable medical treatment Able to read and speak Danish  Exclusion Criteria:  Positive rectal swab for pathogenic microorganisms Use of antibiotics, probiotics and systemic glucocorticosteroids within 4 weeks prior to inclusion Participation in other clinical trials within 30 days prior to inclusion Pregnancy, planned pregnancy or breast feeding Psychiatric disease Abuse of alcohol or drugs