Inclusion Criteria:  Provision of a written informed consent form signed by the participant Age between 18 and 80 years at time of enrollment A care partner must be available for training on SC+ and to be present in the home during all home hemodialysis sessions Participants should be either receiving regular, facility-based hemodialysis therapy for at least 90 days, or performing home dialysis (with any frequency) for at least 90 days and willing to return to facility for purpose of study, and should be clinically stable and deemed suitable for home dialysis in the opinion of the principal investigator Willing to accept a dialysis prescription of 3 sessions per week, 4 hours each session or facility standard during in-clinic visits; 4 sessions, 3.5 hours each session during in-home sessions In the opinion of the Investigator, participant has well-functioning and stable vascular access (tunneled, central venous catheter, arteriovenous fistula, or graft) that allows a blood flow of at least 300 ml/min Home environment is adequate to ensure that appropriate electrical connections, water supply, internet/wifi capacities and any other features necessary for the use and storage of the device and disposables are available Participant or care partner are capable of understanding the nature of procedures and requirements of the study protocol and of home-based hemodialysis, and are willing and capable of complying with protocol and returning to treatment center as stated in protocol Participant or care partner are capable of being trained to use the machine and troubleshoot should an alarm situation occur Documented psychosocial evaluation by a qualified social worker, the treating physician, or a home hemodialysis nurse that supports protocol participation Acceptable physical ability of the participant and/or care partner to perform the hemodialysis treatment at home Financial coverage for treatment costs by Medicare, Medicaid, private insurance, or other arrangement acceptable to participant  Exclusion Criteria:  Pregnant or trying to become pregnant (women of childbearing potential must use medically accepted contraceptive measures) Predicted life expectancy of less than 12 months from first study procedure Major cardiovascular adverse event in the 3 months prior to screening Fluid overload due to intractable ascites secondary to liver cirrhosis Uncontrolled or unstable blood pressure (systolic BP outside the range 90 to 180 mmHg) Unstable coronary artery disease New York Class III or IV heart failure, or ejection fraction less than 30% Participation in other clinical studies that may interfere with the current protocol Known problems with coagulation Active, life-threatening, rheumatologic disease. Hematocrit less than 28% at enrollment Hemoglobin less than 9 g/dL at enrollment Suffering from active severe infection Seroreactive for hepatitis B surface antigen Suffering from active malignancy with expected deteriorating course within 6-12 months History of severe reactions to dialyzer membrane material Expected to receive an organ transplant during the course of the study Have dementia or inability to understand procedures Lack an ability for self-care Are non-adherent to their current dialysis treatments Experience intra-dialytic hypotension defined as a decrease in systolic blood pressure of greater than or equal to 20 mmHg or a decrease in mean arterial pressure of greater than or equal to 10 mmHg provided that the decrease is associated with clinical events (symptoms) and the need for an intervention (ultrafiltration turned off, bolus of fluid) in 3 of 5 previous treatments Is intolerant to heparin Considered in the investigator's opinion to be clinically unstable for any other reason Undergoing outpatient dialysis for the treatment of acute kidney injury (AKI)