Inclusion Criteria:  Full-term newborns who were admitted to the hospital with phototherapy were treated with "neonatal hyperbilirubinemia". Ask about a positive family history of allergic diseases, that is, the parents and siblings are atopic constitutions, including allergic asthma, allergic rhinitis, allergic conjunctivitis and (or) history of AD, as well as a significant increase in IgE. The guardian voluntarily followed the doctor's guidance for treatment and follow-up during the entire study period, and signed an informed consent form. Exclude severe heart, brain, lung, kidney disease and fatal congenital malformations.  Exclusion Criteria:  Those who do not meet the selection criteria or meet the exclusion criteria after review. After enrollment, due to the disease, the jaundice gradually worsened to reach the indications for transfusion therapy. Other skin diseases other than infant AD were diagnosed during the follow-up period. Guardians voluntarily withdraw from the study.