Inclusion Criteria:  Signed informed consent Histopathological confirmation of PDAC and planned standard first-line treatment prior to entering this study OR Patients suspected of primary locally advanced, non-metastatic PDAC based on cross-sectional imaging undergoing diagnostic standard of care (SOC) EUS-FNB procedure Age > 18 years and older Life expectancy greater than 3 months ECOG/WHO Performance Status (PS) 0-1 Patients must have normal organ and marrow function as defined below: White blood cell count (WBC) ≥ 3 x 10⁹/L Platelet count ≥ 100 x 10⁹/L Serum bilirubin ≤1.5 x upper limit of normal (ULN) (patients with Gilbert's Syndrome must have a total bilirubin ≤ 50 mmol/L) PP ≥ 40 or INR ≤ 1.5 Serum creatinine ≤ 1.5 x ULN or CrCl ≥ 40 mL/min (using the Cockcroft-Gault formula)  Exclusion Criteria:  Contraindications for nurse administered propofol sedation (NAPS) Contraindications for EUS-FNB procedure