Inclusion Criteria:  Age: > or = 18 years old Rotator Cuff Tendinitis Atraumatic Full-thickness Rotator Cuff Tear Subjects who speak English Women who are of non-childbearing potential  Exclusion Criteria:  Age: < 18 years old Prior Shoulder Surgery Fracture Acute Traumatic Rotator Cuff Tear Infection Uncontrolled Diabetes Mellitus (HbA1c >8) Uncontrolled High Blood Pressure (Hypertension) Recent Prior Shoulder Injection in either the Subacromial space Workers Compensation History of Peptic Ulcer disease (includes both Gastric and Duodenal Ulcers), Gastrointestinal perforation, Inflammatory Bowel disease (Ulcerative Colitis, Crohn's disease), or any other gastrointestinal pathology Tumor Involving the Shoulder Region Prior history of gastrointestinal bleeding, allergic reactions, impaired renal function, seizures or cardiac arrhythmias Subject unable to provide informed consent Subjects who don't speak English Patients who are pregnant or lactating at time of screening or are of pregnant bearing age Patients currently receiving an aspirin, NSAID regimen or any other anti-inflammatory agents that could affect inflammation response. Patients taking any anti-platelet agents, warfarin or other anticoagulants, or SSRIs. Patients with any bleeding disorders such as coagulopathy, hypercoagulable state, or platelet disorders including thrombocytopenia. Patients with cardiac disease such as congestive heart failure, coronary artery disease, or myocardial infarction. Patients with severe renal failure. Patients with severe liver impairment or active liver disease. Patients with heavy alcohol use; this is defined as consuming 8 or more drinks per week for a woman and 15 or more drinks per week for a man. Patients likely to have severe problems maintaining follow-up, including patients diagnosed with severe psychiatric conditions, patients who live too far outside the hospital's catchment area, patients who are incarcerated and patients who have unstable housing situations. Patients with a known hypersensitivity to bupivacaine or other local anesthetic agent of the amide-type. Patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs Patients who are allergic to aspirin, ketorolac tromethamine and other NSAIDs. Patients who are currently on probenecid or pentoxifylline as described in the approved label of Ketorolac tromethamine injection.