Inclusion Criteria:  Male or female patients aged 18 years and older at screening Patients with at least one defined Venous Leg Ulcer (VLU) suitable for treatment that is no smaller than 2cm2 but no larger than 50cm2 Presence of slough and/or eschar within the reference ulcer suitable for debridement therapy Confirmed, clinically diagnosed VLU (30 days or more) which has been present for less than 2 years Willing and able to attend and comply with study visits and study related activities  Exclusion Criteria:  Diabetic Foot Ulcer A clinical history of a bleeding disorder including haemophilia, purpura, or thrombocytopenia Current or history of use of anti-thrombotic therapy less than 7 days prior to screening. Stage 4 or 5 chronic kidney disease, defined as estimated glomerular filtration rate (eGFR) less than or equal to 30 mL/min Reference ulcer has active infection or florid oedema at screening Oral or intravenous antibiotics for any indication within 72 hours of screening Reference ulcer has exposed tendons, ligaments, muscle, or bone Active osteomyelitis, cellulitis or gangrene in either leg Patients with amputation above a trans metatarsal amputation (TMA) in the target leg Planned vascular surgery, angioplasty, or thrombolysis procedures within the study period, or 4 weeks before screening