Inclusion Criteria:  Provide signed informed consent at the screening visit as well as comply with all study visits and requirements through the end of the study Male or female, age ≥18 years at the screening visit Confirmed diagnosis of PBC in line with the AASLD guidelines UDCA and anti-pruritic medication use will be allowed if meeting additional criteria Qualified pruritus associated with PBC as assessed by Adult ItchRO  Exclusion Criteria:  Pruritus associated with an etiology other than PBC Evidence or clinical suspicion of decompensated cirrhosis or a history of decompensation events Current symptomatic cholelithiasis or inflammatory gallbladder disease History of small bowel surgery/resection impacting the terminal ileum that may disrupt the enterohepatic circulation. Evidence, history, or suspicion of other liver diseases