Inclusion Criteria:  Patients diagnosed with systemic lupus erythematosus (SLE) (ACR criteria, 1997); Pregnant women aged 20-45 years old; Willing to participate in this study, willing to medication and follow-up according to the treatment plan, and sign the informed consent.  Exclusion Criteria:  The cause of previous abortion was known:  Known chromosomal abnormalities in the parent, maternal or embryo.  - Page 3 of 4 [DRAFT] -• Endocrine dysfunction of pregnant women: luteal dysfunction; Polycystic ovarian syndrome; Ovarian premature failure (FSH  ≥ 20uu/ L) in follicular stage;  Hyperprolactinemia thyroid disease; Other hypothalamic pituitary adrenal axis abnormalities in diabetes mellitus. Abnormal anatomy of pregnant women: abnormal uterus; Asherman syndrome; The uterine fibrosis of cervical insufficiency is more than 5 cm. Vaginal infection. Any known serious heart disease, liver, kidney, blood or endocrine disease. Any active infection Active viral hepatitis includes hepatitis B virus (HBV), hepatitis C virus (HCV), human papillomavirus (HPV). Active infections include small intestine herpes zoster virus (VZV), human immunodeficiency virus (HIV), syphilis or tuberculosis. Allergic to prednisone, hydroxychloroquine, low molecular weight heparin or aspirin.  The history of the disease is as follows:  There was a history of peptic ulcer or upper gastrointestinal bleeding in the past. The past history of malignant tumor. The past history of epilepsy or psychosis. Women who disagree or cannot complete the follow-up during pregnancy and after delivery.