Inclusion Criteria:  To be considered eligible to participate in this study, the subject must meet all of the Inclusion criteria listed below:  Hospitalized patients age ≥ 18 with diagnosis of SARS-CoV-2-infection based on positive PCR test result and can provide informed consent Diagnosed with pneumonia due to SARS-CoV-2 Respiratory rate ≥ 25/minute and SpO2 ≤ 93% Review of Chest radiograph, chest computed tomography (CT) scan, or chest ultrasound consistent with bilateral infiltrates. Horowitz index (partial pressure of oxygen/fraction of inspired oxygen [PaO2/FiO2]) ≤ 300. If a subject does not have an arterial line in place, a SpO2/FiO2 ≤ 315 may be used.  Exclusion Criteria:  To be eligible for entry into the study, the subject must not meet any of the exclusion criteria listed below:  Age < 18 Pregnant or lactating women History of heart failure Clinically significant cardiac dysrhythmia, as determined by investigator History renal impairment Presence of any of the following abnormal laboratory values at screening: absolute neutrophil count (ANC) less than 2000 mm3, aspartate aminotransferase