Inclusion Criteria:  Histologically confirmed cancer, Stage I-IV, in one of the following: Cervical, rectal, nodal Non-Hodgkin lymphoma, cutaneous lymphoma, Head & neck cancer Diagnostic/pre-treatment biopsy confirmed suitable for translational research * Performance status - ECOG 0-2 (Refer to appendix 1). Age ≥ 18; no upper age limit. Participant considered suitable for radiotherapy  Before participant registration, written informed consent must be given according to GCP and national regulations.  *Pre-treatment biopsy must be from the gross tumour volume within the planned radiation field and must also:  Have been formalin fixed for >12h and <72h Have tumour tissue and morphology confirmed by H&E staining Contain sufficient tumour cells (approximately 100)  Exclusion Criteria:  Participants deemed unsuitable for a biopsy (during or following radiotherapy) in the opinion of the treating oncologist. Participants who have received chemotherapy within 28 days of starting radiotherapy. Participants with intercurrent or past history of hepatitis B, C or human immunodeficiency virus infection if known. A negative test result for hepatitis B, C and HIV infection is required prior to inclusion in the study.