Inclusion Criteria:  Clinical diagnosis of mild to severe active Ulcerative Colitis (confirmed by endoscopy at screening), Currently taking mesalamine, Be an individual of non-European ancestry. Adult 18 years and older  Exclusion Criteria  Current use of biologics, steroids or other UC medications not including mesalamine. Presence of hepatic or renal insufficiency Pregnancy or lactation Known allergic reactions to components of the Hydroxychloroquine, Chloroquine or quinine products. Any pre-existing macular disease or cardiac disease. Treatment with another investigational drug or other intervention within 4 weeks.