Inclusion Criteria:  Healthy man between the ages of 18 and 35 years. Able and willing to be located easily by providing street address and telephone number (land line and/or cell phone number). Willingness to provide written informed consent. Able and willing to attend all study visits including 6-day stay in the Clinical and Translational Research Center (CTRC) during the trial (with ability to leave the unit during the day) and follow-up visit during the week after treatment. Able and willing to abstain from masturbation during the 6-day stay in the CTRC. Able and willing to abstain from all sexual activity during the course of the study. Acceptable medical history by screening evaluation. Standard physical exam within normal limits (WNL). Serum creatinine WNL. Serum alanine transaminase (ALT) WNL. White blood cell (WBC), polymorphonuclear cell (PMN) and hemoglobin values WNL. Normal urinalysis. Total Complement (CH50) WNL. Urine negative for chlamydia, gonorrhea, trichomonas and mycoplasma. Negative HIV, syphilis, and Hepatitis C (HCV) test results. Negative Hepatitis B (HBV) core and surface antibodies or results consistent with immunization (negative HBV core antibody/positive HBV surface antibody). Denies history of STIs including syphilis and hepatitis B & C. Denies history of bleeding diathesis. Denies history of seizures (due to reports of seizures with ciprofloxacin). Denies history of cancer, except basal cell carcinoma of the skin more than 5 years ago. Denies history of drug abuse. Denies history of psychiatric disorders, except depression controlled by medication. Denies history of genitourinary surgery.  Exclusion Criteria:  Student or employee under the direct supervision of any of the study investigators. Any known immunodeficiencies including complement deficiency, antibody deficiency, chronic granulomatous disease or HIV infection. Psychiatric disorders that would interfere with the integrity of the data or volunteer safety. Unstable depression (defined as receiving either < 3 months of the same medication (and dose) or a decompensating event during the previous 3 months) or depression that, in the opinion of the investigator, will compromise the subject's ability to comply with protocol requirements. Heart murmur or heart disease. Anatomic abnormality of the urinary tract. Any antibiotic treatment in the past 30 days, or azithromycin in the past 60 days. Chemotherapy within the past year. Current steroid use, except for topical application. Allergy to penicillin, ceftriaxone or ciprofloxacin or to lidocaine. Treatment with medications that are contraindicated with ciprofloxacin or ceftriaxone and that cannot be withheld for the single doses given in this study.