Criteria:  Please see https://drive.google.com/drive/folders/1WD618wrywYjEaXzfLTcuK-VCcnb6b-gV for full code and algorithm definitions.  Inclusion Criteria:  Confirmed acute symptomatic proximal PE with or without symptomatic DVT  Exclusion Criteria:  Legal lower age limitations [Day 0, Day 0] Thrombectomy, insertion of a caval filter, or use of a fibrinolytic agent to treat the current episode of DVT or PE [Day -14, Day 0] Other indications for VKA than DVT and/or PE [Day -180, Day 0] Creatinine clearance <30 ml/min [Day -180, Day 0] Significant liver disease (e.g. acute hepatitis, chronic active hepatitis, cirrhosis) or ALAT>3x ULN [Day -180, Day 0] Bacterial endocarditis [Day -180, Day 0] Life expectancy <3 months [Day -365, Day 0] Active bleeding or high risk for bleeding contraindicating treatment with enoxaparin or VKA [Day -180, Day 0] Systolic blood pressure >180 mgHg or diastolic blood pressure >110mgHg [Day -180, Day 0] Childbearing potential without proper contraceptive measures, pregnancy or breastfeeding [Day -180, Day 0] Concomitant use of strong CYP3A4 inhibitors (e.g. HIV protease inhibitors, systemic ketoconazole) or strong CYP3A4 inducers rifampin [Day -14, Day 0]