Inclusion Criteria:  Female or male 18 years of age or older. Patients with a high grade primary glial tumor (Astrocytoma grade 3; Glioblastoma; Anaplastic Oligodendroglioma) Patients scheduled to begin radiation and/or chemotherapy. Able to give informed consent to participate in the research. Enrolled in a social security plan or beneficiary of such a plan.  Exclusion Criteria:  Patient under guardianship or curatorship Psychological disorder (cognitive disorders, vigilance disorders, etc.) or social reasons (deprivation of liberty by judicial or administrative decision) or geographical reasons that could compromise the medical follow-up of the trial. Refusal to participate. Pregnant or breastfeeding woman.