INCLUSION CRITERIA:  In order to be eligible to participate in this study as an affected subject, an individual must meet all of the following criteria:  Have a known (via clinical, radiographic or molecular diagnosis) or suspected skeletal disorder State willingness to comply with study procedures and availability for the duration of the study Be age 2 months or older Be able to understand and sign informed consent document (or availability of a parent/guardian or LAR to provide written consent)  In order to be eligible to participate in this study as an unaffected subject, an individual must meet all of the following criteria:  Be an unaffected family member of an affected enrolled subject State willingness to comply with study procedures and availability for the duration of the study Be age 2 months or older Be able to understand and sign informed consent document (or availability of a parent/guardian)  EXCLUSION CRITERIA:  The below describe exclusion criteria for an individual to participate as an affected subject:  An individual who cannot or is unwilling to abide by the procedures of the protocol. An individual deemed to not have sufficient signs of skeletal disease. An individual who is pregnant.  The belowdescribe exclusion criteria for an individual to participate as an unaffected subject:  An individual who cannot or is unwilling to abide by the procedures of the protocol. An individual that shows signs of skeletal disease. An individual who is pregnant.