Inclusion Criteria:  Adults aged over 18 years old Gout confirmed by identification of urate crystals by joint fluid or tophus analysis or by ultrasound of the affected joint or Gout according to Nijmegen criteria (presence of a score ≥ 8/13) depending on the following items:  Man (2 pts) Previous crisis (2 pts) Involvement of first metatarsophalangeal joint (MTP1) (2.5 pts) Maximum pain within 24 hours (0.5pt) Redness (1 pt) HTA or cardiovascular disease (1.5 pts) SUL > 360 μmol/l during the crisis (3.5 pts)  Chronic kidney disease stage 4/5 or renal transplantation Flare ≤ 5 days Pain assessed by visual analogical scale ≥ 5  Exclusion Criteria:  Participating in another trial including the administration of a drug Active infection History of anakinra or prednisone allergy Contra-indication of anakinra or prednisone Neutrophil count < 1000/mm3 (not due to ethnic cause) Difficulty understanding French Illiteracy Pregnant women or breastfeeding mothers (see PHC article L.1121-5) Persons deprived of liberty by judicial or administrative decision, persons receiving psychiatric care under Sections L. 3212-1 and L. 3213-1 and persons admitted to a health or social institution for purposes other than research (see CSP Article L.1121-6) Major persons subject to a measure of legal protection or unseeding to express consent (see PHC Article L.1121-8) Persons not affiliated to a social security plan or beneficiaries of such a plan (see PHC Article L.1121-8-1)