Inclusion Criteria:  ① sign the informed consent for this study Voluntarily  ≥18 years old and < 70 years old (3) Single lacrimal tract obstruction was included in the study  no purulent secretion of lacrimal passage  Exclusion Criteria:  Patients who meet any of the following criteria will not be eligible for inclusion in this study:  Have a history of lacrimal duct surgery, including lacrimal duct catheterization, laser lacrimal duct plasty, etc  Have a history of allergy to hormones and antibiotics  congenital lacrimal duct malformation  nasal trauma and deformation ⑤ Patients with severe abnormal liver and kidney function and cardiovascular and cerebrovascular diseases In addition to lacrimal duct obstruction, there are other ophthalmic diseases ⑦ Exclude diabetes  Exclusion of pregnancy, lactation women ⑨ Not willing to participate in research