Inclusion Criteria:  Active surveillance cohort: History of Grade Group 1 prostate cancer, first diagnosed ≤24 months prior to date of planned confirmatory biopsy and diagnostic biopsy was preceded by a multiparametric MRI of the prostate Prior negative cohort: Clinical concern for the presence of prostate cancer as determined by the treating urologist and prior negative prostate biopsy performed ≤36 months prior to date of planned biopsy Willingness to sign informed consent and adhere to the study protocol  Exclusion Criteria:  Acute prostatitis within the last 6 months Current non-urologic bacterial infection requiring active treatment with antibiotics Unfit to undergo prostate biopsy under local anesthesia Prior definitive therapy for prostate cancer, such as radiation therapy or partial gland ablation Contraindication to prostate MRI (claustrophobia, pacemaker, chronic kidney disease)