Inclusion Criteria:  Overall inclusion criteria for PCD and PID:  Ages ≥ 5-45 years. Informed consent, and assent from minors.  Inclusion Criteria for PCD:  Clinical features consistent with PCD plus  At least one diagnostic test consistent with PCD:  Biallelic pathogenic variants in PCD-associated genes identified by genetic panel testing including deletion/duplication analysis. Ciliary ultrastructural defect by transmission electron microscopy known to be disease causing, including outer dynein arm defects, outer and inner dynein arm defects, or inner dynein arm defects with microtubular disorganization.  Inclusion Criteria for PID:  - A clinical diagnosis of PID known to be associated with an increased risk of infections, as defined by the European Society of Immunodeficiencies (ESID) registry, AND a genetic confirmation with a known or likely pathogenic variant.  OR a diagnosis of a common variable immunodeficiency (CVID) as defined by the ESID registry:  a. At least one of the following:  i. Increased susceptibility to infection  ii. Autoimmune manifestations  iii. Granulomatous disease  iv. Unexplained polyclonal lymphoproliferation  v. Affected family member with antibody deficiency  b. AND marked decrease of IgG and IgA with or without low IgM levels  c. AND at least one of the following:  i. Poor antibody response to vaccines (and/or absent isohemagglutinins)  ii. Low switched memory B cells (<70 percent of age-related normal value)  d. AND secondary causes of hypogammaglobulinemia have been excluded (e.g., infection, protein loss, medication, malignancy)  e. AND diagnosis established after the 4th year of life  f. AND no evidence of profound T cell deficiency  Exclusion Criteria:  Inability to undergo study procedures Reported increased respiratory symptoms within 3 weeks before the scheduled visit Congenital craniofacial abnormalities (cleft lip and/or palate, hemifacial microsomia) that may result in otologic or sinus disease Congenital hearing loss Diagnosis of Trisomy 21, Kabuki syndrome, DiGeorge anomaly or syndrome, 22q11 deletion syndrome, or CHARGE syndrome History of intranasal illicit drug use (i.e. cocaine) or intranasal abuse of over the counter or prescription drugs (i.e. oxycodone, acetaminophen, etc.) Pregnancy Known selective IgA deficiency, specific antibody deficiency (SPAD), selective IgG subclass deficiency, selective IgM deficiency, mannose-binding lectin deficiency, as well as inborn errors of immunity (IEIs) which are not known to be associated with an increased risk of infections (e.g. autoinflammatory syndromes; unclassified disorders of immune dysregulation) Medical condition that is known to cause secondary immunodeficiency, including human immunodeficiency virus (HIV) infection, acquired immunodeficiency syndrome (AIDS), and/or active malignancy Patients ever having received gene therapy, hematopoietic stem cell transplant, solid organ transplant, or thymus transplant Treatment with targeted immune modulators or immune modifiers Treatment with chronic systemic steroids