Inclusion Criteria:  1. The age ranged from 18 to 80 years. 2. Clinical or pathological diagnosis of cirrhosis; 3. Electronic gastroscopy is planned; 4. To agree and sign the informed consent;  Exclusion Criteria:  1. Hepatocellular carcinoma or other malignant tumors have been or are currently diagnosed; 2. Orthotopic liver transplantation patients; 3. Patients who have undergone transjugular intrahepatic portosystemic shunt (TIPS),or previous surgical shunt; 4. Pregnant women; 5. Neurological or psychiatric disorders;