Inclusion Criteria:  The patient came to visit a coloproctologist Male or female aged over 18 years Signed informed consent form to participate in the study has been obtained Absence of conditions requiring emergency medical care. The patient is not taking VAD for at least 1 month before the date on inclusion to the study  Exclusion Criteria:  Confirmed or suspected malignant tumor Diagnosed coloproctological disease at the time of inclusion Severe somatic disorders (of heart and blood vessels, lungs, kidneys, pancreas, or liver), associated with decompensation of organ functions Mental disorders Presence of contraindications for examination