Inclusion Criteria:  Open reduction internal fixation surgery at Campbell Clinic Surgery Center Body Mass Index less than or equal to 45 Fluent in verbal and written English  Exclusion Criteria:  Known sensitivity to medications in either protocol Renal disease by medical history Concomitant ipsilateral upper extremity injury or condition other than wrist Chronic pain syndrome Consumption of ten consecutive day so opioid use in the previous 90 days Worker's compensation Women who are pregnant, planning to become pregnant, or are breastfeeding Takes either angiotensin-converting enzyme inhibitor or angiotensin II receptor blockers for hypertension