Inclusion Criteria:  Male or female, 18 - 55 years old Willing and able to give informed consent and comply with the study Body mass index (BMI) 18 to 32 kg/m2 and weighs at least 50 kg Women of child bearing potential must have a negative pregnancy test and use a highly efficient birth control method Pre-bronchodilator FEV1 ≥ 70 and ≥80% for Part 1 and Part 2 participants, respectively  Exclusion Criteria:  Clinically significant laboratory test abnormalities Clinically significant abnormal blood pressure and/or pulse rate Resting ECG clinically significant abnormalities Respiratory tract infection within 6 weeks of screening Positive test for active COVID-19 within 2 days prior to administration of IMP