Inclusion Criteria:  Subject is a male or non-pregnant female 18 to 65 years old. Subject has provided written informed consent. Subject has qualifying Submental Fat evaluation score. Subject has had a stable body weight for the past 6 months prior to starting study. Subject is willing to undergo test article injections as directed, comply with study instructions, and commit to all follow-up visits for the duration of the study.  Exclusion Criteria:  Subject is pregnant, lactating, or is planning to become pregnant during the study. Subject has loose skin in the submental area, diffuse SMF, or prominent platysmal bands at rest that may interfere with evaluation of localized fat, in the opinion of the investigator. Subject has had any prior treatment for SMF (e.g., deoxycholic acid, cryotherapy, liposuction, surgery). Subject has any medical condition that affects clotting and/or platelet function Subject has a history of allergy or sensitivity to polidocanol or any of the other ingredients in the test articles.