Inclusion Criteria:  Patients who have been confirmed to have NSCLC by histological or cytological examination Patients with ECOG performance status (PS) 0-1 at the time of obtaining consent Patients aged 20 years or older at the time of obtaining consent  Exclusion Criteria:  Patients with symptomatological cranial nerve system metastasis. If treatment for cranial nerve system metastasis has already been performed and the neurologically recovered state has been maintained for 2 weeks or more before registration, registration is possible. Patients diagnosed with cancerous meningitis Patients who received allogeneic hematopoietic stem cell transplantation Patients with active autoimmune disease