Inclusion Criteria:  18 to 75 years of age (inclusive)  Presence of shock, defined as systolic blood pressure (SBP) less than 90 mmHg with signs of hypoperfusion, including at least one of the following (without alternate causes):  low cardiac index (<2.2 L/min/m2) elevated filling pressures of the left heart (pulmonary capillary wedge pressure [PCWP] >15 mmHg) and/or right heart (central venous pressure [CVP] >10 mmHg) non-perfusing cardiac rhythm or cardiac arrest mixed venous oxygen saturation <60% or >80% without non-shock cause Heart rate >90 beats per minute Respiratory rate >20 breaths per minute White blood cell count >12 or < 4 Temperature >38°C or <35°C SOFA score ≥2 with vasopressor requirement and elevated lactate >2 mmol/L (>18 mg/dL) despite adequate fluid resuscitation Central venous pressure <8 mmHg Obstruction such as pulmonary embolus on imaging Admitted to Abbott Northwestern Rapid Response Team call or request Patients who previously agreed to allow their medical record information to be used for Allina Health research (i.e. Minnesota Research Authorization (MRA) "Yes") or those who have not explicitly declined use of their medical information in Allina Health research (i.e. MRA "Null")  Candidates for the prospective case series must meet the following inclusion criterion:  Interventional assessment and treatment by SWOT Team (full-implementation period only) Patients who previously agreed to allow their medical record information to be used for Allina Health research (i.e. Minnesota Research Authorization (MRA) "Yes") or those who have not explicitly declined use of their medical information in Allina Health research (i.e. MRA "Null")  Exclusion Criteria:  Known or suspected pregnancy Significant trauma BMI > 50 kg/m2 Pre-existing Do Not Resuscitate order Presence of orders limiting resuscitation efforts during the initial resuscitative period (less than 2 hours from the onset of protocol) Refusal to receive whole blood or blood products Severe brain injury (anoxic, traumatic, hemorrhagic or ischemic) presence of an assist device such as intra-aortic balloon pump Advanced chronic organ dysfunction Known or presumed COVID-19 Patients with a status of MRA "No" Patient in ICU at time of shock  Candidates for the prospective case series will be excluded if the following condition is present:  Patients with a status of MRA "No" Patient in ICU at time of shock