Inclusion Criteria:  C49.1 Malignant neoplasm of the connective and soft tissues of the upper limb, including the shoulder girdle C49.2 Malignant neoplasm of the connective and soft tissues of the lower limb, including the hip region Tumor size 7 cm or less For malignant tumors: Grade 2-3 Locally advanced soft tissue sarcomas Absence of regional metastases Tumor recurrence  Exclusion Criteria:  Children, women during pregnancy, childbirth, women during breastfeeding. Military personnel, with the exception of contract military personnel. Persons with mental disorders. Persons detained, taken into custody, serving a sentence in the form of restriction of freedom, arrest, imprisonment or administrative arrest. The age of patients is under 18 years old Histologically confirmed diagnosis of GIST, Kaposi's sarcoma, alveolar, clear cell sarcoma, chondrosarcoma, paraossal osteosarcoma Inoperable tumor A tumor with decay or with the threat of decay The presence of damage to the skin in the affected area The presence of a second malignant tumor Having an active or chronic fungal / bacterial / viral infection Uncontrolled chronic diseases of the liver, kidneys in the acute stage Superficial tumor (within the skin) The use of a reconstructive plastic component using a displaced musculocutaneous flap The use of vascular prosthetics The removed tumor bed is more than 7 cm The presence of a tumor growing into the bone The presence of blood vessels and nerves in the removed tumor bed Presence of metastases Surgical intervention using transplanted skin