Inclusion Criteria:  Newly diagnosed GVHD that meets criteria for Minnesota standard risk except GVHD that is limited to skin rash <50% body surface area (grade I GVHD) OR isolated upper gastrointestinal tract involvement Ann Arbor 1 GVHD by biomarkers GVHD not previously treated systemically (topical therapies and non-absorbed steroids are allowed) Any donor type, HLA-match, conditioning regimen is acceptable Age 0-21 years at the time of screening Performance score (Lansky/Karnofsky) ≥70% Signed and dated written informed consent obtained from patient or legal representative and assent from pediatric patients capable of providing assent  Exclusion Criteria:  Patients treated for GVHD with >0.5 mg/kg prednisone or any steroid treatment for GVHD for more than 3 days prior to enrollment Patients receiving corticosteroids >0.1 mg/kg prednisone (or other steroid equivalent) for any indication within 7 days before the onset of acute GVHD except for adrenal insufficiency, premedication for transfusions/IV medications, or intermittent use for symptom control such as nausea/vomiting Relapsed, progressing, or persistent malignancy or other condition (e.g., known declining donor chimerism) requiring withdrawal of systemic immune suppression Patients with uncontrolled infection (i.e., progressive symptoms related to infection despite treatment, persistently positive microbiological cultures despite treatment, viral reactivations unresponsive to treatment, or any other evidence of severe infection) Severe organ dysfunction including requirement for dialysis, mechanical ventilation, or oxygen supplementation exceeding 40% FiO2 within 7 days of enrollment Significant liver disease evidenced by direct bilirubin >2 mg/dl or ALT or AST >5 times the upper limit of normal Creatinine clearance or estimated glomerular filtration rate <30 ml/min as calculated by institutional practice A clinical presentation resembling de novo chronic GVHD or overlap syndrome developing before or present at the time of enrollment Patients who are pregnant