Inclusion Criteria:  Histologically confirmed as breast cancer. The age of diagnosis was 18-35 years old. ECOG score was 0-2, and the expected survival time was more than 3 months. No serious complications; no liver, kidney, hematopoiesis dysfunction. Informed consent, and patients willing to long-term follow-up. -  Exclusion Criteria:  4 weeks before the start of the study, the use of drugs other than the trial, or participate in another clinical study at the same time, or others with an impact on the results of this study. Having a clear history of neurological or mental disorders (including epilepsy or dementia). Patients have uncontrollable complications, including active infection, symptomatic congestive heart failure, unstable angina pectoris, arrhythmia, decompensated diabetes, uncontrollable hypertension or mental disorders. Pregnant or lactating female patients. HIV infected patients. Patients with other tumors. After comprehensive evaluation, the researchers believe that patients are not suitable for this study.