Inclusion Criteria:  Histological or cytological confirmed advanced or metastatic pancreatic cancer Measurable disease according to the RECIST criteria (version 1.1) for the evaluation of measurable disease  Documented progression after one or more lines of systemic chemotherapy  For the treatment of advanced or metastatic disease Within 6 months after completion of neo-adjuvant therapy or adjuvant therapy Age ≥ 18 years Eastern Cooperative Oncology Group (ECOG) performance 0-1 Written informed consent obtained for clinical trial participation and providing archival tumor tissue, if available  Exclusion Criteria:  Has disease that is suitable for local therapy administrated with curative intent  Has a serious illness or medical condition(s) including, but not limited to the following:  Other concurrently active malignancies excluding malignancies that are disease free for more than 5 years or carcinoma-in-situ deemed cured by adequate treatment. Known brain metastasis or leptomeningeal metastasis. Active infection (i.e. body temperature ≥38°C due to infection). Ascites, pleural effusion or pericardial fluid requiring drainage in last 4 weeks. Intestinal obstruction, pulmonary fibrosis, renal failure, liver failure, or cerebrovascular disorder. Uncontrolled diabetes. Myocardial infarction within the last 12 months, severe/unstable angina, symptomatic congestive heart failure New York Heart Association (NYHA) class III or IV Gastrointestinal hemorrhage. Known human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)-related illness, or hepatitis B or C. Patients with autoimmune disorders or history of organ transplantation who require immunosuppressive therapy. Psychiatric disease that may increase the risk associated with study participation or study drug administration, or may interfere with the interpretation of study results.  Has had treatment with any of the following within the specified time frame prior to study drug administration:  Major surgery within prior 4 weeks. Any systemic therapy within prior 2 weeks. Any radiation within prior 2 weeks. Any investigational agent received within prior 4 weeks. Untreated active hepatitis B or hepatitis C infections. Has received TAS-102. Has unresolved toxicity of greater than or equal to CTCAE Grade 2 attributed to any prior therapies (excluding anemia, alopecia, skin pigmentation and platinum-induced neurotoxicity). Is a pregnant or lactating female. Is inappropriate for entry into this study in the judgment of the Investigator.