Inclusion Criteria:  Adult men and women age 18 years and above. Diagnosis of perianal fistulae associated with Crohn's disease refractory to medical therapy. Presence of perianal fistula(s) with a maximum of 2 internal openings and a maximum of 3 external openings based on clinical assessment. Fit for surgery.  Exclusion Criteria:  Informed consent refusal. Pregnancy or breastfeeding women. Current diagnosis of active cancer or remission for less than 5 years. Evidence of active sepsis or significant localised infection. Patients with HIV, HBV, HCV or treponema infection, whether active or latent. Patients with documented allergies. Patients who have received infliximab or any other biologics in the 4 weeks before the cell treatment administration. Patients currently receiving, or having received within 1 month prior to enrollment into this clinical trial, any investigational drug. Patients with any other co-morbidity/ co-pathologies which is deemed as contraindication to stem cells infusion (infection, administration of steroids).