Inclusion Criteria:  Current infection with COVID-19 written informed consent Confirmed diagnosis of COVID-19 by PCR and/or Positive Serology or any existing and validated diagnostic COVID-19 parameters during this time. 18yrs ≥ Age <66 yrs Chest X-ray showing suggestive of COVID-19 disease. Both gender  The presence of Pulmonary fibrosis or hyper inflammation signs or A syndrome of cytokine release defined as ANY of the following::  Leukopenia or lymphopenia, Ferritin > 500ng/mL or D-dimers ≥ 500 ng/mL Hs>90  Exclusion Criteria:  Lactation and Pregnancy women unlikely to survive beyond 48h Need for mechanical ventilation. cases of multiorgan failure or abnormal renal function and shock. malignancies, autoimmune disease, Perforation of the bowels or diverticulitis. active bacterial or fungal infection. We define impairment of cardiac function as poorly controlled heart diseases, cardiac insufficiency, unstable angina pectoris, myocardial infarction within 1 year before enrollment, supraventricular or ventricular arrhythmia needs treatment or intervention, Uncontrolled hypertension (>180/110 mmHg. Levels of serum transaminase >5 upper references rang Symptoms of active tuberculosis or human immunodeficiency virus (HIV) positivity the patient receiving Vaccines: Live, attenuated vaccines Subjects received monoclonal antibodies within one week before admission. Patients receiving high-dose systemic steroids (> 20 mg methylprednisolone or equivalent), immunosuppressant or immunomodulatory drugs  Contraindications for use in people with psoriasis include concomitant treatment with methotrexate, other immunosuppressant agents, coal tar, or radiation therapy.  -