Inclusion Criteria:  1.Time from poisoning to hospital admission: within 6 hours, 2 The age is greater than 18 years old, less than 65 years old 3 There is at least one target organ dysfunction 4 Previous physical fitness 5 No bad habits (drug use, alcohol addiction)  Exclusion Criteria:  Refuse to join this study Missing/incomplete information Pregnant women, vulnerable groups such as those who have no capacity for civil conduct and cannot determine the consent of their attorneys Chronic organ dysfunction (chronic heart insufficiency, chronic respiratory insufficiency, chronic renal insufficiency, chronic Liver insufficiency) Tumors, blood system diseases, various systemic immune diseases Various infectious diseases (various hepatitis, tuberculosis, AIDS)