Inclusion Criteria:  Permanent bite; Presence of more than 20 teeth; Absence of systemic and chronic diseases.  Non-inclusion Criteria:  More than 5 cavities requiring treatment; Refusal to sign informed consent; Taking supplements and medication containing probiotics or prebiotics 3 weeks before the study; Taking antibiotics (within 1 month before the study); Orthodontic and prosthetic treatment; Allergy to the components of the drugs used in the study.  Exclusion Criteria:  Use of other hygiene products, immunostimulants and antibacterials, probiotics, prebiotics during the study; Refusal to take a given medication; Failure to attend check-ups.