Inclusion Criteria:  Postmenopausal women BMD measured by dual-energy X-ray absorptiometry (DXA)  Exclusion Criteria:  Primary ovarian failure Early menopause Cardiovascular, liver, or renal diseases Surgical menopause History of cancer Receiving treatment known to influence levels of Hcy or bone mineralization (folates or vitamin B12 supplements, menopausal hormonal treatment, corticosteroids, anticonvulsants, heparin, thiazide diuretics, and antiresorptive agents).