Inclusion Criteria:  Willing to receive COVID-19 vaccination as per standard of care Willing and able to provide research blood samples Capable of providing valid informed consent  For cancer patient cohort:  Male or female age >= 18 years Histologically confirmed solid malignancy on or will be starting on systemic cytotoxic chemotherapy  For healthy individual cohort:  Male or female age >= 18 years No history of active malignancy =< 3 years EXCEPTIONS: Adequately treated non-melanotic skin cancer (adequate wound healing is required prior to study entry) or carcinoma-in-situ of the cervix NOTE: If there is a history of prior solid tumor malignancy, it must have been treated curatively with no evidence of recurrence =< 3 years  Exclusion Criteria:  Immunocompromised patients including patients known to be human immunodeficiency virus (HIV) positive or those on immunosuppressive therapy other than chemotherapy in the judgment of the investigator