Inclusion Criteria:  The case is between the ages of 2-18 The patient is followed up in the Pediatric Hematology Clinic The patient is only receiving leukaemia treatment The patient is receiving chemotherapy suitable for the high-risk group (T-ALL, High Risk ALL [Protocol HR1-2-3], Middle Risk ALL [Protocol M, Mtx 5gr / m2] The patient does not have any other chronic disease The patient does not have a systemic infection The patient has a central venous catheter or port catheter Volunteering of the mother and the caregiver parent The caring parent knows Turkish and is open to communication  Exclusion Criteria:  -