Inclusion Criteria:  40-80 years old with a CT identified indeterminate pulmonary nodule and scheduled for biopsy. Nodule to be biopsied is solid ≤2 cm Nodule to be biopsied is subsolid of any size Pulmonary nodule identified as an incidental finding or as part of a lung cancer screening program. The subject must be able to comprehend and sign an approved Informed Consent Form and other applicable study documents. Patients are eligible regardless of race, gender, and ethnicity.  Exclusion Criteria:  Current and or prior diagnosis +/- treatment of non-lung cancer within the past 3 years. Current and or prior lung cancer diagnosis within two years following intent-to-cure surgery.