Inclusion Criteria:  25 < BMI < 40 kg/m2 Waist circumference > 102 cm (men) / 88 cm (women)  Exclusion Criteria:  Type 2 diabetes (HbA1c > 48 mmol/mol) or in treatment with antidiabetic drugs Pregnancy Planned pregnancy Breastfeeding Significant comorbidity expected to unable the subject from completing visits