Donation after Brain Death (DBD) Liver Inclusion Criteria (one or more):  Donor age 50-85 years Anticipated cold ischemia time 10-15 hours (excluding HOPE duration) Macrosteatosis 10-40% Terminal ALT 250-1500 IU/ml Peak ALT within 3 days 1000-3000 IU/ml Terminal total bilirubin 2-4 mg/dl  Donation after Brain Death (DBD) Liver Exclusion Criteria (one or more):  Donor age <18 or >85 years Anticipated cold ischemia >15 hours Macrosteatosis >40% Terminal ALT >1500 IU/ml Peak ALT within 3 days >3000 IU/ml Terminal total bilirubin >4 mg/dl Presence of hemodynamic and/or anatomical donor abnormalities that, in the opinion of the Investigator, make the liver allograft unsuitable for transplant into the recipient subject Liver intended for split transplant Liver from living donor Donor terminal serum Na >160 mmol/L  Donation after Cardio-circulatory Death (DCD) Liver Inclusion Criteria (all):  Donor age 18-60 years Anticipated cold ischemia time <12 hours (excluding HOPE duration) Functional warm ischemia time ≤35 minutes, defined as interval from the time of onset of donor hypotension (MAP <50mmHg) until the time of donor cross clamp Macrosteatosis ≤20% Terminal ALT ≤500 IU/ml Peak ALT within 3 days ≤2000 IU/ml Terminal total bilirubin ≤3 mg/dl  Donation after Cardio-circulatory Death (DCD) Liver Exclusion Criteria (one or more):  Presence of hemodynamic and/or anatomical donor abnormalities that, in the opinion of the Investigator, make the liver allograft unsuitable for transplant into the recipient subject Liver intended for split transplant Liver from living donor Donor terminal serum Na >160 mmol/L  Recipient Inclusion Criteria (one or more):  Subject (or legally authorized representative) is able to provide informed consent and HIPAA authorization Subject is male or female and at least 18 years of age Subject is registered as an active liver recipient on the UNOS waiting list for liver transplantation Subject will undergo primary liver transplantation Subject is willing to comply with the study requirements and procedures Subject with hepatocellular carcinoma as indication for Orthotopic Liver Transplantation; the tumor must be within Milan Criteria or down-staged to Milan Criteria  Recipient Exclusion Criteria (one or more):  Subject will undergo multiple organ transplantations (liver-kidney, liver-lung, etc.) Subject is listed for liver transplantation due to fulminant liver failure (UNOS status 1A) Subject is pregnant Subject is on respiratory (ventilator dependent) and/or cardiocirculatory support (requires at least one intravenous inotrope to maintain hemodynamics) Subject is enrolled in an interventional clinical trial with an investigational drug or device