Inclusion Criteria:  Consecutive patients with a newly diagnosed, objectively confirmed:  symptomatic or unsuspected Deep Vein Thrombosis (DVT) (any location) symptomatic or unsuspected Pulmonary Embolism (PE)  Consecutive patients with any type of cancer whose primary brain tumor or known intracerebral metastases and acute leukemia that meets at least one of the following:  Active cancer defined as diagnosis of cancer within six months or receiving treatment for cancer or any treatment for cancer or recurrent locally advanced or metastatic cancer. Cancer diagnosed within 2 years.  Exclusion Criteria:  pregnant women or breast feeding