Inclusion Criteria:  Age 21 years or greater Biopsy proven primary breast malignancy (BI-RADS 6) Tumor stage T1 and T2, lesion size > 1 cm Primary surgical treatment with breast conservation No previous treatment No contraindications for MRI or MRI contrast agents or high-field MRI (3T) ECOG performance of 0-2 Liver function laboratory test results within the normal institutional reference range (AST (Plasma <=37 U/L); ALT (Plasma <=55U/L); Albumin (Plasma 3.8-5.0 g/dL); Bilirubin (total Plasma <=1.2mg/dL); Creatinine (0.6-1.1 mg/dL))  Exclusion Criteria:  Life expectancy < 3 months Pregnancy or lactation Known contrast agent allergies that require premedication before MRI.  Patients who cannot undergo multiparametric MRI scanning because of:  Weight limits. MRI scanners may not be able to function with patients over 450 pounds. Severe claustrophobia/ examination associated anxiety. MRI unsafe implant Known metastatic liver disease, hepatic neoplasms (benign and malignant), biliary atresia, chronic liver disease (CLD) and cirrhosis. Known moderate hepatic impairment (in phase I, and in phase IIa dependent on safety profile established in phase I) Known hypersensitivity to indocyanine green. Individuals with impaired-decision making capacity