Inclusion Criteria:  age between 25 and 62 years body mass index （BMI）of 18.5-24.9kg/m2 American Society of Anesthesiologists (ASA) score from I to III.  Exclusion Criteria:  history of allergy to narcotic drugs and other drugs cardiopulmonary insufficiency congestive heart failure neuromuscular disease，such as myasthenia gravis severe liver dysfunction hyperkalemia history of malignant hyperfever .