Inclusion Criteria:  Diffuse large B-cell lymphoma，NOS all patients were diagnosed for the first time between 18-75 years old, male and female ECoG 0-3 ，the expected survival was more than 6 months the pregnancy test of women of childbearing age was negative; Male and female patients should agree to take effective contraceptive measures during the treatment period and one year of follow-up; sign the informed consent before the test screening  Exclusion Criteria:  those who are known to be allergic to the study drug or its related components; Or allergic patients uncontrolled psychosis participating in other trials at the same time, and using experimental drugs that may affect the efficacy and safety evaluation impairment of liver and kidney function HIV antibody positive; HBsAg positive hepatitis B carriers and confirmed hepatitis B and C patients; pregnant or lactating women and patients who do not agree to take effective contraceptive measures; the patient is unable to swallow the capsule or has a disease or condition that seriously affects the gastrointestinal function;