Inclusion Criteria:  18 to 70 years old. Need for bronchoscopy (for example, unexplained cough, hemoptysis, localized wheezing and hoarseness, chest X-ray and/or CT scans suggest abnormalities, examination and evaluation of lungs before surgery, chest trauma, lungs Or bronchial infectious disease). ASA classification I-III level. BMI≤30kg/m2. Women of childbearing age have a negative pregnancy test. Before the study, the patients voluntarily signed and dated the informed consent form approved by the institutional review board.  Exclusion Criteria:  Patients with known allergies to benzodiazepines, flumazenil, opioids, naloxone or certain drugs. Patients with long-term use of benzodiazepines or opioids. Patients with a history of drug abuse or alcohol abuse in the past two years. Bradycardia (baseline HR <60bpm) or hypotension (baseline SAP<100mmHg). Asthma or chronic obstructive pulmonary disease(COPD) or FEV1<1.0L. SpO2 <90% before bronchoscopy. Patients who received any study drug within 30 days before screening or less than 7 half-lives of the drug. Any patient with cognitive impairment or inability to provide informed consent.