Inclusion Criteria:  Consenting adult patients (≥18 years) Patient is scheduled for elective major non-cardiac surgery under general anesthesia that is expected to last at least 120 minutes and in whom blood pressure is monitored using an arterial catheter.  Exclusion Criteria:  Patients undergoing emergency surgery OR nephrectomy, liver and/or kidney transplantation Patients suffering from atrial fibrillation and/or sepsis (according to current Sepsis-3 definition) American Society of Anesthesiology (ASA) physical status classification V or VI Disability and/or other circumstances under which the patient is not able to understand the nature, significance and scope of the investigation Pregnancy at the time of surgery Patients without signed informed consent / data protection statement Patient participates in other interventional trials