Inclusion Criteria:  Age ≥ 12 years old; Resident of Toledo city; Seeking care in the public healthcare system with symptoms suggestive of COVID-19 defined as follows: 1) ARI symptoms (nasal congestion, rhinorrhea, anosmia, sore throat, hoarseness, new or increased-from-baseline cough, sputum production, dyspnea, wheezing, myalgia) OR 2) Admitting diagnosis suggestive of ARI (pneumonia, upper respiratory infection, bronchitis, influenza, cough, asthma, viral respiratory illness, respiratory distress, AND/OR respiratory failure). Nasal sample for SARS-CoV-2 PCR test obtained as standard of care.  Exclusion Criteria:  SARS-CoV-2-directed antiviral treatment within the past 30 days; COVID-19 monoclonal antibody therapy within the past 90 days; COVID-19 convalescent serum therapy within the past 90 days; Lack of consent to participate.