Inclusion Criteria:  Man or woman over 18 years of age, less than 75 years Macular Hole of all etiologies Patient with history of opened macular hole after previous pars plana vitrectomy Delay between previous surgery and inclusion (relapse or non-closing hole) > 1 month Patient who received the study information and provided consent Patient who is a members or a beneficiary of a national health insurance plan  Exclusion Criteria:  Ocular surgery other than the macular hole surgery in the prior 3 months Participation in other clinical studies in the prior 3 months Any current or prior ocular pathology that could interfere with the conduct of the study, including visually significant cataract or media opacity Patient with uncontrolled glaucoma on more than 1 intraocular lowering medication Patient with uveitis or other active ocular inflammation or infection Pregnant or breast-feeding woman. Women of childbearing age will be asked to undergo a pregnancy test before being enrolled into the study or to use an effective birth control method Person deprived of liberty by judicial or administrative measures Any other reason which in the opinion of the investigator would preclude the adherence of the schedules visits, safe participation in the study or affect the results of the study