Inclusion Criteria:  Female aged 18- 45 years old; Diagnosed criteria meet the Rotterdam criteria (2003); Insulin Resistance  Exclusion Criteria:  Women who are pregnant or have a pregnancy plan within six months; Confirmed diagnosis of diabetes. Congenital adrenocortical hyperplasia; Hyperprolactinemia; Hyperthyroidism or hypothyroidism; Combined with liver or kidney diseases; Abnormal liver function (≥ 3 times of the upper limit of normal range); Abnormal renal function (GFR<60ml/min/1.73m2); Adrenal or ovarian tumors secreting androgens; Used metformin, glucagon-like peptide-1 receptor agonists, pioglitazone and contraceptives in the last 3 months.