Inclusion Criteria:  Aged 18 years or older and less than 80 years of age. Persistent office systolic blood pressure (SBP) ≥ 140 mm Hg and diastolic blood pressure (DBP) > 90 mm Hg on antihypertensive medicines on two visits separated by a minimum of four weeks. Mean 24-hour systolic ABPM ≥ 130 mm Hg and mean 24 hour diastolic ABPM ≥ 80 mm Hg conducted after direct observed therapy to confirm that antihypertensive medicines were taken as prescribed during the ABPM measurement. Stable drug regimen of 4 antihypertensive medicines consisting of a renin-angiotensin blocker(ACE) or Angiotensin II Receptor Blocker (ARBs), a calcium channel blocker (CCB), a diuretic and spironolactone for 4 weeks at treatment. If spironolactone is not tolerated, the regimen must include instead the addition of further diuretic therapy with either eplerenone, amiloride, higher-dose thiazide/thiazide-like diuretic or a loop diuretic, or the addition of bisoprolol or doxazosin. If none of these medicines are tolerated, then patients on a 3-drug regimen may be included. The Investigator has confirmed that the patient has already tried and/or is not suitable for treatment with currently CE-marked device-based therapies for resistant hypertension as an alternative to baroloop therapy. Willingness and ability to comply with follow-up requirements. Signed informed consent.  Exclusion Criteria:  Any patient in whom access to the vagal nerve is limited by the size of the vagus (a size not compatible with the baroloop cuff). Any patient with a history of injury to the vagus nerve or its branches (e.g., the recurrent laryngeal nerve). Secondary causes of hypertension. Calculated eGFR < 30 mL/min/1.73m2. Type 1 diabetes mellitus or poorly controlled type 2 diabetes mellitus (HbA1c > 10%). One or more episodes of orthostatic hypotension in the past year Requirement for chronic oxygen therapy or mechanical ventilation. Untreated (no CPAP therapy) sleep apnea (AHI > 15) Morbid obesity, defined as Body Mass Index >40 kg/m2 or arm circumference 46 cm. Pacemaker and/or implantable defibrillators. History of transient ischemic accident or cerebrovascular accident during six (6) months prior to screening. Symptomatic carotid artery disease or > 70% occlusion of either carotid artery; any carotid malformation or lesion, a carotid bruit or other abnormal carotid sound. Prior surgery, radiation therapy or scarring in the neck in the region of the carotid artery (e.g., patients with a tracheostomy, extensive thymectomy or thyroid surgery). Limited mobility of the neck secondary to vertebral disease or prior vertebral surgery, including patients who wear a cervical support. History of heart failure (NYHA class III-IV or ejection fraction < 30%), myocardial infarction, unstable angina, coronary bypass or coronary angioplasty during six (6) months prior to screening. Cardiac arrythmias (atrial fibrillation, atrial flutter, etc.) that require anticoagulation or interfere with a consistent measurement of blood pressure. Syncope in the last 6 months. History of bleeding disorders, thrombocytopenia, hemophilia or significant anemia (hemoglobin (Hgb) < 10 gm/dl). Current anticoagulation therapy (excluding antiplatelet therapy with aspirin as a sole therapy). Works night shifts. History of unresolved drug or alcohol use. Active treatment of a psychiatric ailment. Life expectancy of less than 12 months due to other disease. Subject has a condition that, in the opinion of the investigator, precludes participation, including willingness to comply, with all follow-up procedures. Participation in another clinical study for which follow-up is currently on-going. Women who are of child-bearing age or who have the potential to become pregnant Resting heart rate of <40 beats/min for patients on beta blockers or <60 beats/min for all other patients, confirmed at both baseline visits. Baroreflex failure or autonomic neuropathy Symptomatic, uncontrolled bradyarrhythmias Atrioventricular block of any grade Patients who are treated with Pacemaker and/or implantable defibrillators Presence of a vagus stimulator Patients who expect to require magnetic resonance imaging (MRI) of the cervical area Occupational exposure to high levels of non-ionizing radiation that may interfere with therapy Patients with a limited ability to read, understand and execute adjustment procedures (for example, persons suffering from dementia). Likely exposure to diathermy.