Inclusion Criteria:  Patients diagnosed with severe motor and intellectual disabilities (SMID); Pediatric patients ( 29 days; <18 years); Subjects whose enteral nutrition through a nasogastric tube or endoscopic gastrostomy; percutaneous (PEG) involves the administration of a special formula based on whey protein or a formula based on caseinates; Subjects undergoing or not NF surgery.  Exclusion Criteria:  Patients less than 24 months of follow-up at the closing of the database; Patients with less than 12 months of observation.