Main inclusion criteria:  In good health according to medical history, physical examination, vital signs, ECG and clinical chemistry, urinary and hematological laboratory tests  Main exclusion criteria:  Unable or unwilling to use eye-drops Current usage of contact lenses History of eye surgery Sign or symptom of active eye disease History of an eye disease or other condition that could interfere with eye examinations in the study, or with ocular absorption of the investigational product History of inflammatory ocular disease History of cardiovascular or pulmonary disorder Family history of known or suspected hereditary cardiovascular disease Autoimmune disease or known family history of autoimmune disease Any other condition that would contraindicate subject's participation in the clinical study due to safety concerns or compliance with clinical study procedures