Inclusion Criteria:  Subjects age 18 or older able to provide informed consent. Ulcer size 1-300 cm2  4. Undermining/tunneling <3 cm from wound margin 5. Grossly free of necrotic and/or infected tissue 6. Baseline minimum of 2 on VAS pain scale  Exclusion Criteria:  Subjects who meet any of the following criteria will be excluded from the study:  Known allergy to the standard of care or any of the ingredients in KeraStat® Gel or to morphine Wound has heavy or high-volume exudate or necrotic tissue Clinical signs of infection or contamination of the wound Subjects unable to complete the VAS pain score in pain journal Pregnant or nursing Prisoner Any condition the Investigator determines will compromise subject safety or prevent the subject from completing the study