Inclusion Criteria:  ≥ 21 years old of any gender and race; Clinical ischemic stroke (confirmed by CT or MRI) that occurred > 2 months ago; Predominantly unilateral motor impairment with FM-UE score ≤ 62/66; MEPs are inducible from a hand muscle on the affected side (i.e. Abductor Pollicis Brevis (APB) muscle).  Exclusion Criteria:  Any concomitant neurological disorder affecting arm function; Documented history of severe dementia with or without medication before stroke; Subject is unable to do the motor learning practice at the baseline; Presence of any MRI/TMS/ultrasonic stimulation risk factors: an electrically, magnetically, or mechanically activated metal or nonmetal implant including cardiac pacemaker, intracerebral vascular clips, or any other electrically sensitive support system; non-fixed metal in any part of the body; pregnancy (the effect of TMS/ultrasonic stimulation on the fetus is unknown); no history of seizure before or after the stroke; preexisting scalp lesion or wound or bone defect or hemicraniectomy.