Inclusion Criteria:  Patients admitted to ICU with the diagnosis of septic shock as defined according to the Sepsis-3 criteria (suspected or confirmed infection AND vasopressor/inotrope ongoing to maintain MAP ≥ 65 mmHg AND Lactate ≥ 2 mmol/l in the last 6 hours  Exclusion Criteria:  Age <18 years Septic shock for more than 12 hours at the time of screening Acute burn injury >/= 10% of the body surface area Known pregnancy or lactating women Consent not obtainable due to national legislation Patients on chronic dialysis Patients that are known to be allergic to furosemide or metolazone