Inclusion Criteria:  Children (2 days to <18 years) cannulated onto ECMO and admitted to a pediatric or cardiac Intensive Care Unit at participating institutions.  Exclusion Criteria:  ECMO cannulation at an outside institution with transport to a study site >24 hours after ECMO initiation Limitation of care (e.g., family planning to withdraw support) Brain death evaluation within 24 hours of ECMO cannulation Inability to speak or understand English or Spanish Pregnancy.