Inclusion Criteria:  Patients with Diabetic Melitus type 2 Patients with center-involving diabetic macular edema (central macular edema > 300 micrometer) Patients have diabetic retinopathy at the stage of nonproliferative diabetic retinopathy (NPDR) or early PDR (proliferative diabetic retinopathy) or regressed PDR In patients with bilateral macular edema, only one eye is included in the study.  Exclusion Criteria:  uncomplicated cataract surgery history of cataract surgery during last 4 months history of Panretinal Photocoagulation (PRP) during last 4 months any retinochoroidal disease except Diabetic retinopathy optic disc pathology patient with high-risk PDR or advanced PDR one-eye patients patient with glaucoma or uveitis pregnant or lactating patients patients whom topical Timolol or Dorzolamide are prohibited for any reason