Inclusion Criteria:  Age 18 years or older Stage 5 kidney disease (glomerular filtrate rate <15 mL/minute or under substitutive renal therapy Informed written consent  Exclusion Criteria:  Prior allergy/intolerance to rifamycins or isoniazid Pregnancy or breastfeeding Pre-treatment transaminases (ALT and/or AST) >5-fold of normality titer Concomitant drugs contraindicated with rifamycins Having received rifamycins or isoniazid within the two previous weeks Weigh <32 Kgs Inability to understand the nature of the study or to give written consent