Inclusion Criteria:  Patients diagnosed with periodontitis Age ≥ 18 years old Single-rooted and multi-rooted teeth Presence of suprabony periodontal defects at a minimum of two adjacent teeth and a maximum of 7 adjacent teeth in either the maxilla or the mandible with a PD ≥ 5 mm after completion of non-surgical periodontal treatment and re-evaluation Intrabony defect with an intraosseous component < 2 mm  Exclusion Criteria:  Patients with systemic diseases Prolonged antibiotic or anti-inflammatory treatment within 4 weeks prior to surgery Pregnant or lactating Tobacco smokers (≥ 10 cigarettes per day) Multi-rooted teeth with furcation involvement Increased tooth mobility (grade II and III)