Inclusion Criteria:  Age >= 18 years Histologically confirmed, operable, invasive breast cancer. Note: Patients with oligometastatic breast cancer (up to 3 isolated distant metastases) will be eligible after review and approval by principal investigator (PI) Recommended to receive neoadjuvant systemic treatment by their primary medical oncologist and planning to receive one of the regimens Provide written informed consent Willing to return to Mayo Clinic for breast cancer surgery Willingness to provide mandatory blood specimens for future research on breast cancer at Mayo Clinic Willingness to provide authorization to access archival tumor tissue specimens for research  Exclusion Criteria:  Patients who have already initiated neoadjuvant chemotherapy for the current malignancy Inability to provide blood samples based on the judgement of the treating physician Inability to comply with the protocol Patient is pregnant or plans to become pregnant