Criteria for groups with arterial hypertension, chronic obstructive pulmonary disease (COPD), asthma, type 2 diabetes mellitus and nonalcoholic fatty liver disease (NAFLD) (both prospective and retrospective)  Inclusion criteria:  All mentioned groups:  Men and women aged ≥ 18 and <80 Signed informed consent form  Group of arterial hypertention (inclusion criteria):  No current treatment of hypertension Systolic blood pressure <180 mm Hg and diastolic blood pressure <110 mm Hg No clinical signs of other cardiovascular diseases  Group of COPD and asthma (inclusion criteria)  Medical records, confirming COPD or asthma Regular stable treatment of COPD, asthma or any chronic disease for ≥ 4 weeks before the enrollment. If inhaled corticosteroids are being used, regular treatment is required for ≥12 weeks. Absence of acute exacerbations of COPD, asthma or any concomitant diseases 4 weeks before the enrollment No use of genetically engineered biological drugs For patients with COPD after inhalation of salbutamol (400 mcg) the ratio FEV1/FVC is less than 0,70  Group of type 2 diabetes mellitus (inclusion criteria)  Confirmed type 2 diabetes mellitus Stable glucose lowering treatment for ≥ 1 month No systemic corticosteroid treatment 4 weeks before the enrollment  Group of NAFLD (inclusion criteria)  Ultrasound criteria of non-alcoholic fatty liver disease or Confirmed non-alcoholic fatty liver disease using FibroMax test  Control group inclusion criteria  Men and women aged ≥ 18 and <80 years Signed informed consent form  Control group for arterial hypertension (inclusion criteria):  1. No history of cardiovascular diseases, COPD or asthma  Control group for COPD and asthma (inclusion criteria):  1. No history of diabetes mellitus, NAFLD, COPD and asthma  Exclusion criteria for all groups  Age < 18 years and ≥80 years Denial of further participation Obesity with BMI≥40 kg/m2 History of organ transplantion Psychiatric disorder, limiting participation in the study Acute infections Exacerbation of chronic infection 2 weeks before the enrollment Cancer with no radical treatment Pregnancy and lactation Alcohol and drug addition Chronic kidney disease with GFR <30 ml/min/1.73m2 Systemic autoimmune diseases Inflammatory bowel disease Antimicrobial and probiotic treatment 3 months before the enrollment  Additional exclusion criteria adjusted for each group  Group of arterial hypertension (exclusion criteria):  Ischemic heart disease (angina pectoris, myocardial infarction), cerebrovascular disease (stroke, transient ischemic attack), occlusive peripheral arterial disease, revascularization of any vascular bed. Cardiomyopathies Symptomatic arterial hypertension Diabetes mellitus Signs of previous myocardial infarction on ECG Arrhythmias (parohysmal arrhythmias, atrial fibrillation, sinoatrial block, atrioventricular block grade II-III) Signs of current myocardial ischemia on ECG Decompensated heart failure  Group of COPD and asthma (exclusion criteria):  Exacerbation of COPD or asthma 3 months before the enrollment which required antibiotic treatment or systemic corticosteroids.  Group of type 2 diabetes mellitus (exclusion criteria):  Type 1 diabetes mellitus and other specific types of diabetes Severe microangiopathy: proliferative and terminal stage of diabetic retinopathy, chronic kidney disease (GFR < 30 ml/min/1,73 m2) for patients with type 2 diabetes The history of moderate, severe and very severe COPD The history of moderate or severe asthma Vegetarians or vegans  Group of non-alcoholic fatty liver disease (exclusion criteria):  Chronic liver diseases except NAFLD The history of moderate, severe and very severe COPD The history of moderate or severe asthma Vegetarians or vegans Diabetes mellitus  Criteria for groups of heart failure and obstructive atherosclerosis (retrospective)  Inclusion criteria for HF-pEF group:  Men and women aged ≥ 18 and <80 years Signs and symptoms of heart failure Left ventricular diastolic dysfunction Left ventricular ejection fraction ≥50% NT-pro BNP >125 pg/ml Signed study informed consent form  Inclusion criteria for HF-rEF group:  Men and women aged ≥ 35 and <80 years Signs and symptoms of heart failure Left ventricular ejection fraction <50% Signed study informed consent form  Inclusion criteria for obstructive atherosclerosis group:  Men and women aged ≥ 35 and <80 years  Symptoms and signs of obstructive atherosclerosis of any vascular bed:  Ischemic heart disease or Revascularization of coronary, renal, brachiocephalic or lower extremity arteries or carotid endarterectomy or chronic lower extremity ischemia or history of myocardial infarction, stroke, transient ischemic attack or renovascular AH atherosclerotic aorta aneurysm Signed study informed consent form  Inclusion criteria for control group for HF-pEF, HF-rEF and obstructive atherosclerosis  Men and women aged ≥ 18 and <80 years. No signs or symptoms of chronic heart failure No signs of left ventricular diastolic dysfunction No history, signs or symptoms of obstructive atherosclerosis of any vascular bed Signed study informed consent form  Exclusion criteria for groups with HF-pEF, HF-rEF and obstructive atherosclerosis:  Age <18 and ≥80 years. Refuse to sign study informed consent form Body mass index ≥35 kg/m2 Chronic kidney disease with GFR <30 ml/min/1,73 m2 Current smoking Moderate or severe COPD Moderate or severe asthma Acute infections or exacerbation of chronic infections 2 weeks prior to study enrollment History of allergic reactions to gadolinium contrast Hypertrophic cardiomyopathy, dilated cardiomyopathy, restrictive cardiomyopathy: primary, amyloidosis, glycogen storage diseases, hemochromatosis, sarcoidosis, drug induced cardiomyopathy, radiation heart disease, constrictive pericarditis). Connective tissue disease Cancer with no radical treatment Pregnancy or lactation Inflammatory bowel disease Use of antimicrobial agents, probiotics or systemic corticosteroids 3 months before the enrollment