Inclusion Criteria:  Patient with moderate to severe head injury are admitted to the ICU (Intensive Care Unit). patient with stable vital sign and the GCS (Glasgow coma volume) between 5-13 will be included. Patient with normal consciousness and no cognitive or motor function disease before brain injury. Patient aged between 20 to 80 years old and is willing to sign the consent (the agent can sign on behalf of patient).  Exclusion Criteria:  Patients who are vital sign unstable and with severe complication. Patients combined with other terminal illness such as cancer in terminal stage, liver failure, end stage renal failure and so on. Pregnant patients. Any other conditions deemed unsuitable by the physician in charge. Patients (agent of the patient) who did not sign the consent.