Inclusion criteria:  Data on the following subjects is planned to be collected in the project:  Aged from 40 to 65 years inclusively With a high (≥5%) cardiovascular risk measured by SCORE and low density lipoprotein (LDL) levels of ≥2,5 mmol/L, or with a very high (≥10%) cardiovascular risk measured by SCORE and LDL levels ≥1,8 mmol/L or With atherosclerotic stenosis of brachiocephalic arteries of >50% in the absence of cerebrovascular disease  Exclusion criteria:  No contraindications to statin treatment and not taking stating at study entry.  History of the following clinically significant events and conditions:  (а) myocardial infarction (б) stroke (в) transient ischemic attack  Presence of the following diseases at the time of a statin administration:  (а) ischemic heart disease (б) heart failure (в) peripheral artery atherosclerosis (г) atherosclerotic stenosis of brachiocephalic arteries with cerebrovascular disease .  Subjects must give their consent for processing of their personal data for the purposes of this scientific project.