Inclusion Criteria:  Participation in the PACAP cohort with written informed consent for being randomized in future studies Histologically proven local recurrence after primary PDAC resection Minimum age of 18 years  Exclusion Criteria:  Distant metastases Expected lifespan < 3 months Ineligibility for MRI or CT according to the protocol of the local radiology department; Highly selective cases with resectable, isolated local recurrence without the need for either systemic or local ablative induction therapy, eligible for re-resection according to the expert panel.