Inclusion Criteria:  HIV-1 sero-positive, with documented HIV-1 infection by official, signed, written history Male with body weight ≥ 50 kg or female with body weight ≥ 45 kg, aged 20 years or older. No breastfeeding or pregnancy for women. Have been receiving ART for more than 3 years by screening visit 1 (SV1). Both male and female patients and their partners of childbearing potential must agree to use 2 medically accepted methods of contraception Subjects must sign the informed consent before undergoing any study procedures.  Exclusion Criteria:  Subjects with active systemic infections, except for HIV-1 Any exposure to a monoclonal antibody within 12 weeks prior to the first dose of study drug. Current receiving treatment regimen for hepatitis B, hepatitis C or latent tuberculosis Any alcohol or illicit drug use Receipt of any other investigational study agent(s) within 90 days before SV2. Currently on the treatment for diabetes.