Inclusion Criteria:  Informed consent signed; Non-metastatic Breast cancer patients confirmed by pathology; Adult (>18 years old, <80 years old); Female; Must undergo oncoplastic or conventional breast-conserving surgery;  Exclusion Criteria:  Inflammatory breast cancer, Stage IV breast cancer patients; Have other malignant tumors; Pregnancy women; Have severe co-morbidities that compromise the patients' compliance to our protocol, or endanger the patients; Refuse breast-conserving surgery.