Inclusion Criteria:  The subjects were able to understand the informed consent, voluntarily participate in and sign the informed consent, with good compliance and cooperation with follow-up. A histopathological or cytological diagnosis of epithelial ovarian, fallopian tube or peritoneal cancer. Previous systematic treatment ≤ 2 lines, and progression in platinum based regimens or recurrence within 6 months after the end of platinum regimen. 1) Imaging progression of recurrence and progression should be clearly recorded;2) Neoadjuvant + adjuvant chemotherapy with platinum regimen ≥ 6 cycles, and platinum regimen after recurrence / progression ≥ 4 cycles;3) If there is progression during the treatment of platinum based regimen, the treatment cycle is not limited;4) Recurrence / progression within 6 months after the end of neoadjuvant / adjuvant therapy is considered to have received the first-line systematic treatment. Measurable cancer lesion according to Response Evaluation Criteria in Solid Tumors (RECIST) v1.1; ≥18 years old; Eastern Cooperative Oncology Group(ECOG) performance status score 0-1; Estimated life expectancy >3 months;  The function of important organs meets the following requirements:  white blood cell count (WBC) ≥ 3.0×109/L, absolute neutrophil count (ANC) ≥ 1.5×109/L, platelets ≥ 100×109/L, hemoglobin ≥ 90g/L; ALT, AST≤ 2.5×ULN; liver metastasis: ALT、AST≤ 5.0×ULN; serum albumin ≥ 28g/L; total bilirubin ≤ 1.5×ULN; serum creatinine ≤ 1.5×ULN, creatinine clearance rate ≥60 mL/min; PT≤ 1.5×ULN; The subjects had no history of allergy to camptothecin or its components; Non surgical sterilization or female subjects of childbearing age need to use a medically approved contraceptive method after signing the informed consent, during the study treatment period and within 6 months after the end of the study treatment period; non surgical sterilization female subjects of childbearing age must have negative blood HCG test within 3 days before entering the study; and they must be in non lactation period. Taking drugs orally; The subjects had recovered and treatment will start more than 4 weeks after the end of previous surgery, chemotherapy, targeted therapy and radiotherapy.  Exclusion Criteria:  Subjects who have been treated previously with topotecan, Irinotecan or other topoisomerase I inhibitors; Other anticancer therapy including any investigational agent within 30 days prior to the first dose of the investigational drug gimatecan; Within 14 days before the first dose of the investigational drug gimatecan, any active infection requiring systemic anti infective treatment; Subjects with a history of major gastrointestinal surgery (e.g., total gastrectomy, small bowel resection) or gastrointestinal dysfunction that may alter drug absorption and activity in vivo; Severe cardiovascular disease, such as NYHA grade 3-4 heart failure; Patients who have been treated previously with intravenous or oral drugs that affect CYP isoenzymes within 7 days prior to the first dose of the investigational drug gimatecan; A history of immunodeficiency (including a positive HIV test result);Presence of active hepatitis B , hepatitis C (positive for hepatitis C antibody, and HCV-RNA levels higher than the lower limit of the assay); Pleural effusion, pericardial effusion or ascites with clinical symptoms can not be controlled by puncture drainage or other treatment; Subjects with hereditary or acquired bleeding tendency (hemophilia, thrombocytopenia, etc.), interstitial pneumonia or pulmonary fibrosis, and active tuberculosis (whether or not treated) in the past year; Vaccinated with live attenuated vaccine within 4 weeks; Subjects had other active malignancies within 5 years before the first dose of the investigational drug gimatecan; Subjects with active meningeal metastasis or uncontrollable and untreated brain metastasis. Other considered unsuitable for the study.