Inclusion Criteria:  adult patient histologically proven or asserted cirrhosis on a combination of clinical, biological, endoscopic and radiological criteria follow-up of cirrhosis > 6 months subject informed of the study and not having objected to it.  Exclusion Criteria:  immunosuppression not related to liver disease: HIV, variable common immune deficiency, chemotherapy, anatomical splenectomy, immunosuppressive treatments for non-hepatic disease vaccine contraindication.