Inclusion Criteria:  Recurrent or metastatic malignant solid tumor confirmed by histology or cytology Disease progression or intolerance after receiving standard treatment With evaluable lesions (RECIST 1.1 standard) Tumor tissue pieces with sufficient formalin-fixed paraffin-embedded (FFPE) can be used for genetic testing ECOG PS score 0-4 (3-4 points only for patients with tumor burden) Sign the informed consent form  Exclusion Criteria:  The subject is participating in any other clinical research; Researchers believe that serious or uncontrolled medical diseases (ie uncontrolled diabetes, chronic kidney disease, chronic lung disease, or uncontrolled active infections, mental illnesses/social conditions that restrict compliance with research requirements) that will confuse the analysis of research treatment response ； Patients during pregnancy or lactation