Inclusion Criteria:  Women with biopsy confirmed or clinically suspected LS English-speaking Electing to undergo Fractionated CO2-laser therapy Willing and able to undergo concomitant 0.05% clobetasol propionate treatment  Exclusion Criteria:  Prior surgery with placement vaginal mesh for repair of pelvic organ prolapse (does not include vaginal mesh for anti-incontinence procedure "sling" or prior mesh sacrocolpopexy) Prior laser, topical immunomodulators or systemic therapy for LS Active genital infection^ Suspicious vulvar lesion that has not been evaluated Known vulvar or vaginal malignancy or active treatment for other malignancy Planning pregnancy Prior pelvic radiation therapy Topical corticosteroid use on the vulvovaginal tissues in the past 2 weeks*  Contraindication or allergy to clobetasol propionate 0.05%  Eligible for inclusion after washout period of 2 weeks ^Eligible for inclusion after treatment