Inclusion Criteria:  18-40 years of age and premenopausal (female) or 18-50 years of age (male) at time of diagnosis Histologic diagnosis of colorectal adenocarcinoma Able and willing to participate in the informed consent process Eligible for curative adjuvant or neoadjuvant therapy for colon or rectal cancer Willing and able to complete protocol questionnaires Rectal patients only: Individuals who will be receiving chemotherapy, followed by chemoradiotherapy (ChemoRT)  Exclusion Criteria:  Prior systemic treatment for this malignancy Active or prior secondary malignancy History of ovarian resection (if female) Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception until the termination of gestation, confirmed by a positive hCG laboratory test.