Inclusion Criteria:  Depression major disorder. 2 or more antdepressives resistant a treatment. Consent informed signed  Exclusion Criteria:  Schizophrenia or other disorders. Suicide risk. Unstable medic illness or unsuitable controlled. Disorder for use of active substances. Comorbidity with other psychiatric pathologies. Montreal Cognitive Assessment <26/30, cognitive deterioration. Incapacity for realizing physical exercise because of osteoarticular, cardiovascular, or metabolic difficulty.