Inclusion Criteria:  Adults between the ages of 18-80 years CKD Stage IV (eGFR = 15-29 mL/min) with declining kidney function for a period > 6 months Serum Creatinine > 2.5 mg/mL Adherence to low protein diet (LPD) of 0.6-0.8 g/kg/day  Exclusion Criteria:  Those on probiotics in the past 3 months Pregnancy, breast feeding or females of child-bearing potential who are unwilling to use a reliable form of contraception. Immunosuppressant medications therapy specific to immune mediated renal diseases HIV/AIDs Underweight (BMI ≤ 18.5) Subject with an infection that requires oral antibiotic administration. Those with gastrointestinal disease (irritable bowel syndrome or anal fissures or anal fistulas or perianal abscesses or perianal infections or diverticular diseases or colitis or colon polyps) Those with internal prosthetics of any kind Those on anticoagulant medicines Those on peritoneal dialysis Those with acute kidney injury Those with mental conditions or medically debilitating disease/disorder other than CKD, which, in the judgment of the investigator, would interfere with or serve as a contraindication to adherence to the study protocol or affect the ability to give informed consent or affect overall prognosis of the patient.