Inclusion Criteria:  Arm 1  Pregnant woman > 18 years Signed informed consent for participation At least one previously completed parturition with ICP Willingness and ability to comply with the study procedures, visit schedules and other instructions regarding the study  Arm 2  Pregnant woman ≥ 18 years (±5 calendar years from the matched subject in arm 1) Signed informed consent for participation At least one previously completed parturition No previous ICP Willingness and ability to comply with the study procedures, visit schedules and other instructions regarding the study  Exclusion Criteria:  Multifetal pregnancy (twins, triplets etc.) Latin American ethnicity Use of any systemic antibiotics within 3 months prior to enrollment Medical history of liver disease (other than previous ICP for subjects in arm 1) Medically significant gastrointestinal disorder which, in the opinion of the investigator, may affect the results or the subject ́s ability to comply with the study History or concurrent status of any clinically significant disease or disorder which, in the opinion of the investigator, may influence the results or the subject ́s ability to participate in the study Participation in any other clinical study that included drug treatment within 3 months prior to enrollment Serious bacterial or chronic viral infection such as human immunodeficiency virus (HIV) or hepatitis virus at enrollment visit Any other condition which, in the Investigator ́s opinion, makes the subject unsuitable for study participation