Inclusion Criteria:  Patients who enter the Intensive Care Unit of the CES Clinic during the recruitment period with: Diagnosis of septic shock of any origin according to the definition of the Sepsis-3 consensus. Acute renal injury according to the KDIGO 2012 classification that requires continuous renal replacement therapy and that its origin is presumed to be septic origin. In invasive ventilatory support. Informed consent previously filled out by a guardian.  Exclusion Criteria:  Patients under 18 years of age and women in pregnancy or postpartum will be excluded. Chronic kidney disease that requires RRT on an outpatient basis before admission to the ICU. Contraindication to the use of heparins or another anticoagulant Dissent to escalate therapeutic measures Terminal or irrecoverable condition according to the criteria of the specialist in critical medicine and intensive care