Inclusion Criteria:  Between the ages, 5 to 18, and are diagnosed with neurogenic bladder. Use CIC (CIC: Clean Intermittent Catheterization) daily to empty the bladder. A recent history of fecal incontinence within the last 3 months More than two episodes of urinary tract infection and/ or pyuria within the last 6 months  Exclusion Criteria:  An anatomical abnormality of the bladder neck. Known intractable origin of bacteriuria such as urolithiasis (kidney stone) or nonfunctional renal segment. Received bladder augmentation surgery Patient without completion of toilet training  Either received following treatment diagnosed according to Peristeen® product safety guideline:  Anorectal malformation Colorectal cancer Endoscopic polyp removal surgery in 3 months Ischemic colitis Acute inflammatory bowel disease Acute intestinal diverticulum. Radiotherapy to the colon Long-term corticosteroid usage