Inclusion Criteria:  The participant is an adult female or male ≥18 years of age. Note: Age requirements are as specified or allowed by local regulations. The participant has a diagnosis of asthma for at least 6 months and has been stable without exacerbation or change in medications for at least 1 month..  Current Asthma Therapy: The participant has been maintained for at least 1 month on stable doses of:  medium or high dose inhaled corticosteroids (ICS)±another controller. any fixed dose combination ICS (low, medium, or high) with long-acting beta agonist (LABA)±another controller. Women of non-childbearing potential, or congenitally sterile, or 1-year postmenopausal. Women of childbearing potential must have a negative β-human chorionic gonadotropin (β-HCG) test result and practice a highly effective method of birth control prior to investigational medicinal product (IMP) administration and 30 weeks after the dose of IMP. The participant, as judged by the investigator, is able to continue their current asthma maintenance medications throughout the study.  NOTE- Additional criteria apply, please contact the investigator for more information.  Exclusion Criteria:  Life threatening asthma, defined as a history of asthma episode(s) requiring intubation and/or associated hypercapnea, respiratory arrest, hypoxic seizures, or asthma-related syncopal episode(s). The participant has a suspected bacterial or viral infection of the upper or lower respiratory tract, sinus, or middle ear that has not resolved at least 2 weeks before the screening period. Note: Participants who develop an upper respiratory infection/lower respiratory infection (URI/LRI) during the run-in period may rescreen 2 weeks after symptoms resolve and undergo coronavirus disease 2019 (COVID-19) testing. Participants with a confirmed infection with COVID-19 within 3 months prior to the screening visit. The participant has an eosinophilic condition including hypereosinophilic syndrome, eosinophilic pneumonia, eosinophilic granulomatosis with polyangiitis (EGPA [Churg Strauss syndrome]), or allergic bronchopulmonary aspergillosis. The participant has an active helminthic or parasitic infection currently or within the last 6 months. The participant has a history of malignancy other than fully resected basal cell carcinoma of the skin. The participant has any clinically significant, uncontrolled medical or psychiatric condition (treated or untreated) that would interfere with the study schedule or procedures, interpretation of efficacy results, or compromise the participant's safety. The participant has known history of, or a positive test result for, hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) antibodies (Ab), or human immunodeficiency virus (HIV) Types 1 or 2 Ab (according to 4th generation serology testing). The participant is a pregnant or lactating woman, or plans to become pregnant during the study. The participant has previously participated in a study with TEV-53275. The participant has participated in another study of an IMP (or a medical device) within the previous 30 days or is currently participating in another study of an IMP (or a medical device). The participant has been treated with a monoclonal antibody used to treat asthma or other inflammatory conditions within the washout period (5 half-lives), has demonstrated hypersensitivity or anaphylaxis to a monoclonal antibody (Appendix G),or is currently using or has used a systemic immunosuppressive medication within the last 6 months. NOTE: Prior depemokimab exposure is prohibited without exception. The participant has a history of chronic alcohol or drug abuse within the previous 2 years. The participant currently smokes or has a smoking history of 10 pack years or more (a pack year is defined as smoking 1 pack of cigarettes [20 cigarettes]/day for 1 year), OR the participant used tobacco products within the past year (eg, cigarettes, cigars, chewing tobacco, or pipe tobacco), OR the patient has smoked marijuana within 1 month, OR the participant has a history of "vaping" tobacco, marijuana, or any other substance within 24 months. Vulnerable participants (eg, people kept in detention).  NOTE- Additional criteria apply, please contact the investigator for more information