Key Inclusion Criteria:  Be at least 65 years of age at the time of signing the informed consent form. Be currently receiving an antiretroviral regimen for ≥ 3 months prior to the screening visit. Have documented plasma HIV-1 RNA < 50 copies/mL for a minimum of 3 months on current ART regimen. Have a plasma HIV-1 RNA < 50 copies/mL at screening visit.  Key Exclusion Criteria:  Have resistance to tenofovir (K65R/E/N, ≥3 thymidine analogue mutations or T69-insertions), primary INSTI-resistance, or a history of failure on an INSTI-based regimen. Have been treated with B/F/TAF Participants with CrCl <30 mL/min Known or suspected severe hepatic impairment (Child-Pugh Class C)