Inclusion Criteria:  Male or female of any race, at least 20 years of age at Visit 1 Screening. Has a subject reported history (including physician diagnosis) of dry eye disease in both eyes for at least 3 months prior to Visit 1. Has SANDE score ≥50 in either frequency or severity of symptoms of dryness and/or irritation at Visit 1.  Have all of the following in the same eye at Visit 1:  Fluorescein Tear Break-Up Time of ≤5 seconds. Corneal fluorescein staining score of moderate or more in any field (inferior, superior or central). Report a severity score of moderate or more on ocular dryness and at least one of the other symptoms on the GLIA Ocular Surface Disease Symptoms Questionnaire. Has provided written informed consent. Be able and willing to follow oral and written instructions, including participation in all study assessments and visits.  Exclusion Criteria:  Comorbidity with other severe or chronic eye conditions that in the judgment of the investigator will interfere with study assessments, such as but not limited to corneal opacities and scars, dystrophies, epithelial scarring, infections, history of blood clots, etc. Has infections, or inflammatory skin lesion in or around the dosing area. Best corrected visual acuity baseline <20/200. Has a condition or history that, in the opinion of the investigator, may interfere significantly with the subject's participation in the study. Wear contact lens within 7 days prior to Visit 1. Anticipate change of vision correction or anticipate any ocular procedures during study period. A woman who is pregnant or testing positive in the blood pregnancy test at screening, nursing an infant, or planning a pregnancy. Has a known adverse reaction and/or sensitivity to the study drug or its components. Use of topical ocular cyclosporine (e.g. Restasis®), lifitegrast (Xiidra®), diquafosol (Diquas®), eye gels, eye ointments, any administration route of steroids, anti-histamines, antipsychotics, antidepressants and NSAIDs within 30 days prior to Visit 1. Routine use (more than once a week) of a chlorinated swimming pool during study period. Unwilling or unable to cease using the following medications during the study period (from Visit 1 to Visit 6): Topical ocular cyclosporine (e.g. Restasis®), lifitegrast (Xiidra®), diquafosol (Diquas®), eye gels, eye ointments, any administration route of steroids, anti-histamines, antipsychotics, antidepressants and NSAIDs.. Unwilling to cease the use of sunscreen and face scrubs on the forehead or eye area during study period. Smoke within 3 months prior to Visit 1. Ongoing glaucoma treatment within 30 days prior to Visit 1 and during study period. Currently enrolled in an investigational drug or device study within 30 days prior to Visit 1 and during study period.