Inclusion Criteria:  Age ≥ 18 and ≤ 80 years old Office systolic blood pressure (SBP) ≥ 135 mmHg or on a stable dose of antihypertensive medication(s) for at least 30 days Documented daytime systolic ambulatory blood pressure (ABP) ≥ 135 and < 175 mmHg HbA1c ≥8.0% - ≤11.0% on a stable dose of antidiabetic medication(s) for at least 90 days  Waist circumference ≥ 102 cm (male) and ≥ 88 cm (female)  Exclusion Criteria:  Renal artery (RA) anatomy on either side OR common hepatic artery (CHA) anatomy, ineligible for treatment including the following:  CHA OR RA artery diameter < 4.0 mm or > 7.0 mm CHA OR RA artery length < 20.0 mm Only one functioning kidney Presence of abnormal kidney tumors CHA or RA with aneurysm Pre-existing stent or history of angioplasty in target arteries Fibromuscular dysplasia of the CHA or renal arteries Presence of CHA OR RA diameter stenosis >30% Individual lacks appropriate arterial anatomy for treatment or for maneuvering of the device from the femoral artery to the target location(s) Prior renal denervation procedure Type 1 diabetes mellitus Use of insulin within 90 days prior to Index Procedure eGFR < 45 mL/min per 1.73 m2 One or more documented severe hypertensive crisis (persistent or elevated hypertension > 180 mmHg accompanied by clinical symptoms) in the 90 days prior to Index Procedure One or more documented hyperglycemia episodes (requiring hospitalization) in the 90 days prior to Index Procedure One or more Severe hypoglycemic events (severe cognitive impairment requiring external assistance for recovery) in the 90 days prior to Index Procedure Evidence of active infection within 7 days prior to Index Procedure Documented history of chronic active inflammatory bowel disorders such as Crohn's disease or ulcerative colitis Any history of cerebrovascular event (e.g., stroke, transient ischemic event, and cerebrovascular accident) within 6 months prior to Index Procedure Myocardial infarction within 6 months of Index Procedure Heart failure (New York Heart Association [NYHA] Class III-IV) at time of consent. Documented confirmed episode(s) of stable or unstable angina within 6 months prior to Index Procedure Documented history of persistent or permanent atrial tachyarrhythmia Chronic oxygen support or mechanical ventilation other than nocturnal respiratory support for sleep apnea Night shift workers Chronic regular use (e.g., daily use) of NSAIDs for 6 months or greater. Aspirin therapy is allowed. Active implantable medical device (e.g., ICD or CRT-D, neuromodulator/spinal stimulator, baroreflex stimulator) Known Primary pulmonary hypertension (HTN) (> 60 mmHg pulmonary artery or right ventricular systolic pressure) Individual has known pheochromocytoma, Cushing syndrome, primary hyperaldosteronism, coarctation of the aorta, untreated hyperthyroidism, untreated hypothyroidism, or primary hyperparathyroidism. (Note: Treated hyperthyroidism and treated hypothyroidism are permissible.) A history of bariatric surgery, baroreflex activation therapy, or liver transplant, or these procedures are planned in the 365 days following Index Procedure Previous hepatobiliary surgery/intervention that in the opinion of the investigator could preclude the ability to perform denervation of the CHA History or diagnosis of proliferative retinopathy or advanced autonomic neuropathy (e.g., orthostatic hypotension attributable to autonomic neuropathy, a diagnosis of gastroparesis, or a clinical history strongly suggestive of delayed gastric emptying) ALT or AST greater than 200 U/L History or evidence of active / suspected chronic liver or biliary disease including Hepatitis B, Hepatitis C, autoimmune hepatitis, primary biliary cholangitis (PBC), primary sclerosing cholangitis, Wilson's disease, alpha-1-antitrypsin deficiency, hemochromatosis, drug-induced liver disease, bile duct dilation and obstruction, symptomatic gallstones, liver cancer or liver cirrhosis. Note: subjects with past symptomatic gallstones and a cholecystectomy are not excluded. Current or chronic pancreatitis Documented contraindication or allergy to contrast medium not amenable to treatment Limited life expectancy of < 1 year at the discretion of the investigator Any known, unresolved history of drug use or alcohol dependency, lacks the ability to comprehend or follow instructions, or for any reason in the opinion of the investigator, would be unlikely or unable to comply with study protocol requirements or whose participation may result in data analysis confounders Pregnant, nursing, or planning to become pregnant (documented negative pregnancy test result required documented within a maximum of 7 days before Index Procedure for all women of childbearing potential) Concurrent enrollment in any other investigational drug or device trial (participation in noninterventional registries is acceptable)