Inclusion Criteria:  Any male or female aged between 18 and 80 on the date of signing the informed consent; Diagnosed as hypercholesterolemia ; Fasting triglyceride was less than 5.6 mmol/L during screening: Understand the study procedures and methods, volunteer to participate in the study, and sign the informed consent.  Exclusion Criteria:  A history of the following diseases or treatments during the screening period:  Known allergies to PCSK9 inhibitors or test drugs, or severe allergic reactions to other antibody drugs in the past; Participated in clinical studies of other drug interventions within the last 1 month (except for patients who failed in screening), or those who are within 5 half-lives of the drug before screening (whichever is longer);  Any of the laboratory test indicators meets the following criteria:  Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) was more than 3 times the upper limit of normal value (ULN), and total bilirubin was more than 2 times ULN during the screening period or at random; The creatine kinase (CK) was more than 3 times of ULN during the screening period or at random;  Have used the following drugs:  PCSK9 inhibitors had been used in the previous 6 months; Continuous systemic corticosteroid therapy with doses exceeding or equivalent to 10mg of prednisone (oral or intravenous) within the previous 3 months was screened.  Other circumstances:  Women of reproductive age who are fertile but did not use contraception within 4 weeks before the screening period;Women who are pregnant or breastfeeding;Not agreed during the trial or at 24 weeks after the last dose Subjects who are considered by the investigator to have any unsuitable factors for participating in the study or who have poor compliance.