Inclusion Criteria:  1. H. pylori-infected outpatients with endoscopically proven peptic ulcer diseases or gastritis.  Exclusion Criteria:  Previous H. pylori-eradication therapy ingestion of antibiotics, bismuth, or PPIs within the prior 4 weeks patients with allergic history to the medications used patients with previous gastric surgery the coexistence of serious concomitant illness (for example, decompensated liver cirrhosis, uremia) pregnant women.