Inclusion Criteria:  Age ≥ 18 years Patients admitted to the ED of Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome Femur Fracture Patients who signed the informed consent Able to take analgesic therapy both orally (OR) and intravenously (IV) Able to define pain by VAS  Exclusion Criteria:  Age <18 years Allergy to paracetamol Unable to take analgesic therapy both orally (OR) and intravenously (IV) Unable to define pain by VAS