Key Inclusion Criteria:  Fasting TG ≥ 500 mg/dL (5.65 mmol/L) at Screening and Qualification Patients should be on standard of care lipid-lowering medications per local guidelines unless intolerant. Lipid-lowering medications should be optimized and stabilized for at least 4 weeks prior to Screening to minimize changes in these medications during the study.  Key Exclusion Criteria:  Hemoglobin A1c (HbA1c) ≥ 9.5% at Screening Platelet count < 100K/cubic millimeters at Screening or Qualification Alanine aminotransferase or aspartate aminotransferase > 3.0 × upper limit of normal Total bilirubin > upper limit of normal unless due to Gilbert's syndrome Estimated GFR < 40 mL/min/1.73 m^2