Inclusion Criteria:  18 to 75 years of age at the time of signing informed consent. Body mass index (BMI) between 25.0 and 40.0 kg/m2, inclusive, at Screening. Female participants will be of non-childbearing potential. Male participants will agree to use contraception while on study intervention and for at least 6 months after the last dose of study intervention. SAD cohorts only: Participants must be in good health. Repeat-dose cohort only: Type 2 diabetes mellitus (T2DM) treated with lifestyle modification or metformin, and in otherwise good health except for well-controlled common conditions associated with T2DM, such as hypertension and dyslipidemia.  Exclusion Criteria:  History of, or treatment for, psychiatric illness, including anxiety or depression within 5 years of the Screening visit. Participants with a history of attempted suicide or clinically significant suicidal ideation. History of cardiovascular disease. Blood pressure >155 mmHg systolic or >95 mmHg diastolic. History of alcoholism or drug/chemical abuse within 2 years prior to Screening. Alcohol consumption of >21 units per week for males and >14 units for females. One unit of alcohol equals 12 oz (360 mL) beer, 1.5 oz (45 mL) liquor, or 5 oz (150 mL) wine. History of significant hypersensitivity, intolerance, or allergy to more than one class of drugs. Positive hepatitis panel and/or positive human immunodeficiency virus test. Participants whose results are compatible with prior immunization may be included. SAD cohorts only: Fasting glucose >126 mg/dL.