Inclusion Criteria:  Both gender; Age from 18 to 80 years; Diagnosed with ME; Agree to under optical examination and willing to complete questionnaires and take medications as scheduled; and Agree to participate in the study and provide written informed consent. (for those illiterate subjects, their family member can sign the consent form upon subject's agreement)  Exclusion Criteria:  Known ocular media opacities, such as cataract, vitreous hemorrhage, asteroid hyalosis, that affect the determination of retinal thickness from OCT imaging; Known clinically significant macular edema (CSME). The definition of CSME: if one or more of the following criteria are met 1) retinal thickening at or within 500 μm of the center of the macula; 2) hard exudates at or within 500 μm of the center of the macula, if associated with adjacent retinal thickening; 3) a zone or zones of retinal thickening one disc area in size, at least part of which is within one disc diameter of the center of the macula; On concomitant oral or injectable corticosteroids, leukotriene inhibitors, anti-VEGF, immunosuppressants or other Chinese herbal medicine for the treatment of ME within past month; Impaired hematological profile and liver / renal function; Documented pregnant or lactating; or Subjects participating in other clinical studies at the same time.