Inclusion Criteria:  18 to 85 (inclusive) years-old subjects of both sexes; A signed written informed consent form; Genetically confirmed diagnosis of limb-girdle muscular dystrophy (type 2B) (a case group)  Exclusion Criteria:  A subject who is an investigator, study assistant, study coordinator and a member of the other personnel indirectly or directly associated with the conduct of the study; Acute medical conditions associated with visceral dysfunction, life-threatening conditions which occurred less than 6 months prior to enrollment into the study such as acute cardiac, renal, hepatic insufficiency, myocardial infarction or an acute cerebrovascular accident (stroke) as well as infectious diseases; Excessive alcohol consumption (> 20 g/day).