Inclusion Criteria:  Patients undergoing open cardiac surgery at VCU Age18 to 80 years American Society of Anesthesiologists Physical Status 1-3  Exclusion Criteria:  history of excessive bleeding partial thromboplastin time > 35 s prothrombin time > 35 s fibrinogen < 200 mg/dL platelet count < 100,000/L history of infection and fever within 4 weeks before surgery use of steroid or immunosuppressant within 4 weeks before surgery