Inclusion Criteria:  Diagnosis of diabetes mellitus (Type 1 or Type 2) Macular thickening secondary to diabetic macular edema (DME) involving the center of the macula Decreased visual acuity attributable primarily to DME Ability and willingness to provide written informed consent and to comply with the study protocol Willingness to allow Aqueous Humor collection For women of childbearing potential: agreement to remain abstinent or use at least two acceptable contraceptive methods that result in a failure rate of <1% per year during the treatment period and for at least 12 weeks after the final dose of study treatment  Exclusion Criteria:  Hemoglobin A1c (HbA1c) of greater than (>) 12% Uncontrolled blood pressure, defined as a systolic value greater than (>)180 millimeters of mercury (mmHg) and/or a diastolic value >100 mmHg while a patient is at rest Currently pregnant or breastfeeding, or intend to become pregnant during the study Prior treatment with panretinal photocoagulation or macular laser to the study eye Any intraocular or periocular corticosteroid treatment within the past 16 weeks prior to Day 1 to the study eye Prior Iluvien or Retisert implants within 3 years prior to Day 1 to the study eye Prior anti-VEGF treatment within the past 8 weeks prior to Day 1 to the study eye Prior administration of IVT brolucizumab in either eye Any proliferative diabetic retinopathy Active intraocular or periocular infection or active intraocular inflammation in the study eye Any current or history of ocular disease other than DME that may confound assessment of the macula or affect central vision in the study eye Any current ocular condition which, in the opinion of the investigator, is currently causing or could be expected to contribute to irreversible vision loss due to a cause other than DME in the study eye Other protocol-specified inclusion/exclusion criteria may apply