Inclusion Criteria:  Patients with wounds larger than 20mm Patients aged 18 to 75 years old  Exclusion Criteria:  Have a serious medical condition, such as heart failure, acute liver failure, severe kidney disease (dialysis or predialysis patients) or New York heart association class iii-iv. Pregnant or breastfeeding. Allergy or intolerance to any study drug. Patients who have taken anticoagulant drugs (aspirin, clopidogrel, etc.) in the past week but are contraindicated for endoscopic polyp treatment. Other imaging findings suggest patients with advanced cancer. Patients with severe gastrointestinal diseases, such as intestinal obstruction or perforation, active ulcerative colitis, toxic colitis, and toxic megacolon