Inclusion Criteria:  Patient with de Beta-thalassemia major Patient with regular blood transfusion regimen (every 4 - 6 weeks) informed and signed consent weight > 30kg Hemoglobin > 7g/dL  Exclusion Criteria:  Emergency situation Patients receiving antithrombotic drugs (anticoagulants such as Vitamin K antagonism, heparin or direct oral anticoagulant) or antiplatelet drugs; women of childbearing age without contraception pregnancy deprivation of liberty no consent