Inclusion Criteria:  Morphological verification of cutaneous melanoma. Verification of metastases is not necessary ECOG 0-1 Age of patients - 18 years and older No prior chemotherapy, immunotherapy, radiation or hormonal therapy Adequate contraception for women of childbearing age Written consent of the patient to participate in the study  Exclusion Criteria:  Non-compliance with the previously listed criteria Pregnancy and breastfeeding Therapy with systemic corticosteroids and/or other immunosuppressants within 4 weeks before the screening or a high probability of the need for their use during the study for the treatment of intercurrent pathology History of another malignancy other than the study indication under this trial within 5 years of study enrollment. Does not apply to subjects who underwent successful definitive resection of basal or squamous cell carcinoma of the skin, in situ cervical cancer, in situ breast cancer, or other in situ cancers.