Inclusion Criteria:  Patient Informed consent form must be appropriately obtained under the applicable local and regulatory requirements. Each patient must sign a consent form prior the enrollment to document their willingness to participate. The subject is male or female, aged 1 - 19 years The subject must have a histologically proven recurrent/ refractory or very high-risk CNS tumors Patients must be in good overall physical condition, which allows tumor biopsy Patients must have a life expectancy of at least 3 months. Patients must have a tumor amenable to image-guided or direct vision biopsy and be willing and able to undergo a tumor biopsy and/or blood taking for molecular profiling. Patients must be accessible for follow-up.  Exclusion Criteria:  Patients with known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial. Pregnant and/or breastfeeding women, if applicable No intention to treat the patient.