Inclusion Criteria:  Male or Female with SCD Participants with SCD ages 18 to 60 years, inclusive. Participant has provided documented informed consent. Patients with stable and close to baseline hemoglobin value Patients on HU should be on stable dose for at least 90 days prior to signing ICF  Exclusion Criteria:  Patients had more than 10 VOC within 12 months of screening Patients who are pregnant or nursing Patients who receive RBC transfusion therapy regularly or received an RBC transfusion for any reason within 60 days of signing the ICF Hospitalized for sickle cell crisis or other vaso-occlusive event within 14 days of signing the ICF or within 24 days prior to Day 1 treatment