Inclusion Criteria:  Patients had residual or recurrent atypical meningioma (grade II) after surgery (Simpson score) Age: ≥ 18 years old Karnofsky performance Status ( KPS) ≥ 70 Written consent  Exclusion Criteria:  Pregnancy Neurofibromatosis type 2 (NF2) Concomitant aggressive haematological or solid neoplasm