Inclusion Criteria:  Age 21 to 65 years at screening Medically healthy (does not meet criteria for an exclusionary medical condition) No current DSM-5 psychiatric diagnosis No current use of psychotropic medications Ability/willingness to complete all study activities Use of acceptable contraceptive methods (sexually active males and women of childbearing potential) Speaks and reads English No use of psychedelic drugs within prior 3 months of dosing visit Able to swallow oral medications  Exclusion Criteria:  Pregnancy Current exclusionary medical illness Current DSM-5 psychiatric diagnosis and/or suicidal thoughts/behavior within prior 12 months Clinically significant safety lab abnormalities (i.e., Complete Blood Count with Differential, Comprehensive Metabolic Panel, and urinalysis) Clinically significant electrocardiogram (ECG) Hypertension or tachycardia First degree relative(s) with a history of schizophrenia, schizophreniform disorder, bipolar I disorder, bipolar II disorder, major depressive disorder with psychotic features