Inclusion criteria (all must be present):  Age ≥18 years Clinically stable patient with known CAD CCTA showing stenosis in at least one major epicardial vessel of stentable/graftable diameter, in whom clinically indicated IVUS is planned within 45 days of the CCTA and FFRct available FFRct successfully processed Willing to comply with all aspects of the protocol Agrees to be included in the study and able to provide written informed consent.  Exclusion criteria (all must be absent):  1. CCTA showing no stenosis Uninterpretable CCTA by HeartFlow assessment, in which image quality prevents FFRCT from being processed. Acute chest pain CABG prior to CCTA acquisition Prior history of PCI for 3 or more vessels MI less than 30 days prior to CCTA or between CCTA and ICA. Suspicion of acute coronary syndrome (acute myocardial infarction or unstable angina) Known complex congenital heart disease Tachycardia or significant arrhythmia Subject requires an emergent procedure Evidence of ongoing or active clinical instability, including acute chest pain (sudden onset), cardiogenic shock, unstable blood pressure with systolic blood pressure <90 mmHg, and severe congestive heart failure (NYHA III or IV) or acute pulmonary edema Any active, serious, life-threatening disease with a life expectancy of less than 2 months Currently enrolled in another study utilizing FFRCT or in an investigational trial that involves a non-approved cardiac drug or device Persons under the protection of justice, guardianship, or curatorship