Inclusion Criteria:  Age 18-80 Diagnosis of multiple sclerosis (revised 2017 criteria) EDSS 0-7 Plans to initiate treatment with ocrelizumab within 6 months or has been on an approved regimen of ocrelizumab for >12 months as part of their clinical care Individual must be able to provide consent, read/write/comprehend English Language  Exclusion Criteria:  Clinical relapse within 3 months of first on-study infusion Cognitive impairment limiting the ability to consent or fill out the electronic survey Currently pregnant, planning to become pregnant during the study period, or currently breastfeeding Untreated psychiatric illness (such as major depressive disorder, Bipolar disorder, psychotic disorder, schizophrenia) Active substance abuse disorder Significant medical comorbidities (such as history of severe traumatic brain injury, stroke, systemic cancer or chronic infection) Chemotherapy use within 6 months of first study infusion Prior treatment with alemtuzumab within 12 months of first study infusion Prior treatment with a B-cell depleting therapy other than ocrelizumab within 12 months of first on-study infusion