Inclusion Criteria:  Neoplasia group: high suspicion of pancreas neoplasia based on computed tomography and/or nuclear magnetic resonance. Inflammatory group: high suspicion of acute or chronic pancreatitis based on computed tomography and/or nuclear magnetic resonance. Control group: patients without a history of any type of solid or hematologic malignancy, hepato-pancreato-biliary disease (including fatty liver and pancreas disease), tobacco/alcohol habits, or morbid obesity with bariatric surgery criteria; who require EUS evaluation (e.g., suspicious of a subepithelial lesion in the context of chronic dyspepsia).  Exclusion Criteria:  Uncontrolled coagulopathy, kidney/liver failure, or any comorbidity with important impact on cardiac risk assessment (NHYA III/IV); Impossibility of EUS-guided biopsy (only for neoplasia or inflammatory group); Pregnancy or nursing; Refuse to participate in the study and/or to sign corresponding informed consent.