Inclusion Criteria:  Males and females using suitable methods of contraception, or females of non-childbearing potential Consent to study participation Body weight ≥ 50 kg and body mass index 19 - 30 kg/m2 Vital sign assessments within the normal ranges Healthy as determined following physical and laboratory examinations at screening visit Spirometry readings (FEV1 and FVC) to be ≥ 80% of predicted value  Exclusion Criteria:  Acute or chronic illness detected at the screening visit Respiratory tract infection within 4 weeks of the screening visit Use of prescribed or OTC medication within 14 days of the screening visit History of regular alcohol use over the recommended limits within 6 months of screening, or history/evidence of alcohol or drug abuse Smoker or use of tobacco products within 6 months of screening Abnormal blood or urine laboratory test results at screening Recent participation (within 3 months) in another clinical trial Current, or history of, allergy that may be contraindicated