Inclusion Criteria:  Age: ≥18  Adequate bone marrow function defined as:  absolute neutrophil count (neutrophil and bands) of ≥ 1,500/mm3 (≥ 1.5 x 109/L) platelet count > 150,000/mm3 hemoglobin of ≥ 10 g/dL Adequate renal function, defined by serum creatinine ≤ 1.5 x lab ULN.  Adequate hepatic function defined as:  serum albumin ≥ 3.0 g/dL total bilirubin ≤ 1.5 times lab ULN. alanine aminotransferase (ALT) ≤ 2.0 times lab ULN. aspartate aminotransferase (AST) ≤ 2.0 times lab ULN For female subjects of childbearing potential WOCBP, a negative pregnancy test at screening and the female subjects must agree to either abstain from sexual intercourse or use reliable, effective contraception such as hormonal contraceptive, intrauterine device (IUD), diaphragm with spermicide, contraceptive sponge, or use of a condom by their partner. Women of non-childbearing potential include those who cannot get pregnant medically, including post-menopausal women and those with a history of hysterectomy or surgical sterilization. Male participants must agree to abstain from sexual intercourse or use a reliable, effective contraceptive method, such as condoms, or have had a vasectomy. Alternatively, female partners of male subjects enrolled in the study must use reliable, effective contraception such as hormonal contraceptive, intrauterine device (IUD), diaphragm with spermicide, or contraceptive sponge. Signed and dated Institutional Review Board (IRB) approved informed consent before any protocol-specific screening procedures are performed.  Exclusion Criteria:  Treatment with any biologicals (including intravenous immunoglobulin) or investigational agents within the last 4 weeks (or 5 half-lives, whichever is longer).  Uncontrolled or significant cardiovascular disease, including:  A myocardial infarction within the past 6 months. Uncontrolled angina within the past 3 months. Congestive heart failure within the past 3 months, defined as New York Heart Association (NYHA) Class II or higher. Uncontrolled hypertension (blood pressure >160 mm Hg systolic or >100 mm Hg diastolic). Dementia or altered mental status that would prohibit the understanding or rendering of informed consent. Treatment with immunosuppressant agents, including corticosteroids or cyclosporine within the last 4 weeks. Serious uncontrolled medical disorders, such as uncontrolled diabetes, active peptic ulcer disease, cerebrovascular accident within three months, ongoing congestive heart failure, and any other condition, which in the opinion of the investigator, would put the subject at risk by participating in the trial. History of severe allergic or anaphylactic reactions to humanized or murine monoclonal antibodies. Abnormal ECG with any clinically significant findings or with QTc >470 ms. Infection requiring treatment with antibiotics within 3 weeks prior to screening.  Infectious disease:  • Positive HIV, RPR, Hepatitis B or C, TB (QuantiFERON-TB Gold (QFT)/ IGRA)  History of immunodeficiency. Female subjects who are pregnant, planning to become pregnant during the course of the study, or breast-feeding. Major surgery within 28 days prior to Day 0. History of progressive multifocal leukoencephalopathy (PML) or other demyelinating disease.