Inclusion Criteria:  Biopsy proven soft tissue sarcoma of the extremity, trunk, or head and neck No prior sarcoma-directed therapy Age ≥ 18 years Karnofsky performance status ≥ 60 Able to understand and sign an informed consent Life expectancy of greater than 12 weeks Hypofractionated or conventionally fractionated radiotherapy using Intensity Modulated Radiation Therapy (IMRT) are both deemed feasible and safe neoadjuvant treatments, at the treating physician's discretion Operable disease and medically fit for surgery, based on the opinion of the consulting surgeon; surgery within 5-14 days of completion of radiation therapy (RT) Adequate bone marrow function as defined by absolute neutrophil count > 500/mcL, hemoglobin > 8 g/dL, platelets > 50,000/mcL; adequate renal function as defined by creatinine clearance > 30 mL/min  Exclusion Criteria:  Pregnant Unable to undergo imaging or positioning necessary for radiotherapy planning