Inclusion Criteria:  Adult 18 -80 years old Must have laboratory confirmed COVID-19(A patient with laboratory confirmation (Positive RT-PCR) of COVID-19 infection, irrespective of clinical signs and symptoms according to Ain Shams University Hospitals Consensus Statement on Management of Adult COVID-19 Patients.  Must have severe or immediately life-threatening COVID-19,  Severe disease is defined as:  Dyspnea, Respiratory frequency ≥ 30/min, Blood oxygen saturation ≤ 93%, Partial pressure of arterial oxygen to fraction of inspired oxygen ratio < 300, and/or lung infiltrates > 50% within 24 to 48 hours  Life-threatening disease is defined as:  respiratory failure, septic shock, and/or multiple organ dysfunction or failure Must provide informed consent by patient or his/her legal guardian or Professional Legal Representative  Exclusion Criteria:  Mild to moderately affected COVID 19 confirmed patients. pregnancy, lactation. known hepatic failure. Patient who is not likely to comply to study procedures. Creatine clearance <30 ml/min. Elevated transaminases > 5 fold ULN.