Inclusion Criteria:  Has signed the ICF and is able to read and understand the information provided in the ICF. Is 21 to 65 years of age (inclusive) at screening. No intention of quitting smoking in the next 30 days. Willing and able to comply with the requirements of the study. Owns a smartphone running iOS or Android with text message and data capabilities compatible with the eResearch app.  Exclusion Criteria:  Is unhealthy or cannot participate in the study for any reason (e.g., medical, psychiatric, and/or social reason) as judged by the Investigators or designated medical staff based on all available assessments from the screening period (e.g., vital signs, physical examination, concomitant medications and medical history). PHQ-9 score greater than 9, or a score greater than 0 on item #9 ("Thoughts you would be better off dead, or of hurting yourself in some way") at screening. Body mass index (BMI) greater than 40.0 kg/m2  Use of any of these products in the past 30 days:  Illegal drugs (or if the urine drug screen is positive for cocaine, THC, amphetamines, methamphetamines, or opiates), Experimental (investigational) drugs that are unknown to participant, Chronic opioid use. Pregnant or nursing (by self-report) or positive urine pregnancy test.  Participant enrollment numbers met.  -