Inclusion Criteria:  Chronic heart failure patients with reduced ejection fraction due to ischemic heart disease.  Exclusion Criteria:  Restrictive or hypertrophic cardiomyopathy, hypertensive cardiomyopathy, acute myocarditis, acute coronary syndrome or acute myocardial infarction in the last 2 months, valvular disease (except mitral regurgitation secondary to left ventricular dilation).