Inclusion Criteria:  Patients willing to sign an informed consent and capable of understanding the features of this clinical trial. Willing to keep a weekly diary and undergo observation for four months Non-pregnant patients 18-55 years of age with MS according to the revised McDonald criteria and meeting the Possner criteria for clinically defined MS. EDSS scores of 2·0 to 5·5 points assessed at least three months after the last acute attack of MS.  Exclusion Criteria:  Patients with evidence of active proliferative retinopathy. Patients with poorly controlled diabetes mellitus (HbA1C > 8.5%). Patients with renal insufficiency (Creatinine > 2.5) or failure. Infection as evidenced by WBC count of >15,000 k/cumm and/or temperature >38C. History of organ transplant. History of previous or active malignancy, except for localized cutaneous basal or squamous cell carcinoma or carcinoma in situ of the cervix History of sickle cell anemia  Cardiovascular conditions:  Exercise limiting angina ( Canadian Cardiovascular Society Class greater or equal to 3 Congestive heart failure (New York Heart Association class greater or equal to 3 Unstable angina Acute ST elevation myocardial infarction (MI) within one month Transient ischemic attack or stroke within one month Severe valvular disease