Inclusion Criteria:  Patient with WM according to diagnostic criteria Patients with WM followed in one of the centre of North-Western region. Patients requiring first-line or subsequent-line therapy Patients agreement for giving informed consent. Social insurance system affiliation  Exclusion Criteria:  Patients with another chronic B-cell malignancy patients with other lymphoplasmacytic proliferations patients with marginal zone lymphoma. Patients with WM and histologic transformation Absence of informed consent