Inclusion Criteria:  All Participants:  Informed Consent provided by participant or substitute decision maker Age 18 and older Participant must rate his/her level of proficiency speaking and understanding English at 7 out of 10 or higher on the a modified version of the LEAP-Q * Telephone or internet access Ability to attend a LifeLab facility of participant's choice to provide blood sample  Under the care of a primary medical care provider (e.g. family physician or nurse practitioner) and/or specialist and their name provided for purposes of reporting incidental findings.  Participants must have proficiency in English to understand study instructions and respond to questionnaires licensed for use in English only. Study does not have resources for translation of study documents/certified translators.  Participants with Neurodegenerative Diseases:  Participant-reported diagnosis of meeting "possible or probable" clinical criteria for AD, MCI, PD, PD+ (e.g. MSA/PSP/CBD/LBD), ALS, FTD or Cerebrovascular disease. Aging adults without a specific diagnosis, but who have cognitive symptoms (Telephone Interview for Cognitive Status-Modified (TICS-M; Total score <32) will be assigned to the MCI cohort.  Exclusion Criteria:  Underlying conditions which may interfere with the participant's ability to participate in the study or may compromise study results, including but not limited to:  Contraindication to the biosensors as outlined by biosensor manufacturers, Substance abuse within the past year or history of alcohol or drug abuse which the study team feels may interfere with the participant's ability to comply with the study procedures. Known brain tumour (e.g. glioblastoma, metastatic cancer to the brain) Prior brain surgeries that the study team feels will interfere with participation Known history of poor venous access or difficulties with blood draws Significant psychiatric disorders (e.g. untreated major depression, psychosis)