Inclusion Criteria  Subjects must be ≥18 years of age at the time of signing the informed consent form. Confirmed diagnosis of chronic phase MPN: high risk ET (HU failure/intolerance), low-intermediate 1 (DIPSS 0-1) PMF Verified mutation in CALR exon 9 PS ≤ 2  Adequate organ function:  Absolute neutrophil count ≥ 1000/mm3 Platelet count ≥ 50,000/mm3, Creatinine ≤ 2.5 mg/dL, Total bilirubin ≤ 2 mg/dL, (except in patients with Gilbert Syndrome who can have total bilirubin < 3.0 mg/dL) Transaminases 3 times above the upper limits of the institutional normal. INR<2 if off of anticoagulation. Patients on anticoagulation therapy with an INR>2 may be enrolled at the discretion of the investigator if they have not had any episodes of severe hemorrhage. Females of childbearing potential (FCBP) must have a negative serum or urine pregnancy test with a sensitivity of at least 50 mIU/mL within 10 - 14 days prior to starting study medication and must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control, one highly effective method and one additional effective method AT THE SAME TIME, at least 4 weeks before prior to first dose of vaccine. FCBP must also agree to ongoing pregnancy testing. Men must agree to use a condom during sexual contact with a female of child bearing potential even if they have had a successful vasectomy. Ability to understand and the willingness to sign a written informed consent. Ability to adhere to the study visit schedule and all protocol requirements  Exclusion Criteria  Other invasive malignancy in the past 3 years except non-melanoma skin cancer, localized cured prostate cancer and early stage breast cancer on HRT. Active autoimmune disease Uncontrolled serious infection Known immunodeficiency Pregnant and breastfeeding women Not willing to use contraception Current use of immunosuppressive medications including steroids Current Ruxolitinib or Fedratinib use Current use of hydroxyurea Current use of INF (use of anagrelide is permitted) Treatment with other experimental drugs Any significant psychiatric/medical condition per investigators judgment