Inclusion Criteria:  Age between18 and 75 years. HCC confirmed by histopathology and/or cytology, or diagnosed clinically. Accompanied with tumor thrombus involving unilateral portal vein branch. Child-Pugh class A or B. Eastern Cooperative Group performance status (ECOG) score of 0-2. Serum bilirubin ≤ 51.3 μmol/L, albumin ≥ 28g/L, ALT and AST ≤ 5 times of the upper normal limit, and creatinine ≤ 20g/L. Prothrombin time prolonged for less than 4s or international normalized ratio < 1.7. Neutrophilic granulocyte count ≥ 1.5×10^9/L, platelet count ≥ 50×10^9/L, and hemoglobin level ≥ 85g/L; At least one measurable intrahepatic target lesion. Life expectancy of at least 3 months.  Exclusion Criteria:  Diffuse HCC. Extrahepatic metastasis. Tumor thrombus involving both the left and right branch of portal vein or main portal vein. Hepatic vein and/or vena cava invasion. History of organ or cells transplantation. Previous treatment with TACE, intra-arterial infusion chemotherapy, radiotherapy or systemic therapy. History of other malignancies. Serious medical comorbidities. Female patients who are pregnancy or breastfeeding.