Inclusion Criteria:  Diagnosis is based on Revised International Diagnostic Criteria (Read et al. 2001b). Age from 12 to 70 years old. Patients have no contraindication of prednisone and immunosuppressive therapy, as determined by the investigator based on the results of laboratory and physical examinations. Written informed consent is provided.  Exclusion Criteria:  Patients with other ocular diseases or fundus diseases: diabetic retinopathy, neovascular/wet age-related macular degeneration History of renal or hepatic insufficiency, heart failure, systemic inflammatory disease or any other condition that, in the opinion of the investigator, would put the patients at risk by participating in the protocol. History of infectious disease like chronic or active hepatitis B infection, HIV infection, immunodeficiency syndrome, chronic recurring infections, or active tuberculosis. Female patients who were pregnant or considering becoming pregnant during the study.