Inclusion Criteria:  Aged 60 to 85 years Major depression disorder Under a stable dose of all psychotropic medication during the stimulation period.  Exclusion Criteria  Having any current psychiatric comorbidity or history of substance dependence. Having active suicidal ideation currently. Having severe physical illness, recent and/or current unstable medical disorders. Having history of cancer or chemotherapy. Dementia or MMSE<24. Having TMS contraindicated (seizure disorder, history of seizures, metal in the head, pacemakers, history of craniotomy)