Inclusion Criteria:  ST-elevation acute myocardial infarction within 3-14 days Planned elective percutaneous revascularization of angiographically documented coronary chronic total occlusion (CTO) Left ventricular ejection fraction < 50% when hospitalized for index acute myocardial infarction or within 12 months before planned revascularization of coronary CTO Provision of signed and dated informed consent prior to study specific procedures  Exclusion Criteria:  Current unstable angina Significant valvular heart disease NYHA IV heart failure symptoms Severe untreated hypertension (>180/110 mmHg) Female not post-menopausal Contraindications for adenosine infusion (in patients with CTO): Severe renal failure (estimated glomerular filtration rate < 30 ml/min) Atrial fibrillation with ventricular response > 110 bpm No acoustic window for left ventricle assessment by echocardiography Previous cardiac surgery