Inclusion Criteria:  Diagnosed as potentially resectable with consensus by the panel of liver surgeons stage BCLC A/B/C, without extra-hepatic involvement No previous anti-HCC treatment Eastern Co-operative Group performance status 2 or less Liver function: Child's A or B (score < 7)  Exclusion Criteria:  Evidence of hepatic decompensation including ascites, gastrointestinal bleeding or hepatic encephalopathy  underlying serve cardiac or renal diseases Known or suspected allergy to the investigational agent or any agent given in association with this trial Patients ineligible for hepatic artery embolization, or PD-1 antibody