Inclusion Criteria:  Angiographic diagnosis of SCAD Admission for ACS or other manifestations of ischemia Informed consent  Exclusion Criteria:  Cardiogenic shock or severe hemoynamic instability Concomitant severe heart disease requiring surgical correction (in <2 years) Medical condition seriously limiting life expectancy (< 2 years) Allergies or contraindication to drugs required in one of the study arms; the patient may be randomized in the other arm (factorial design)