Inclusion Criteria:  Women with suspicious mammographic microcalcifications (Breast Imaging Reporting and Data System [BI-RADS] categories 4 or 5) occupying an area equal to or exceeding 4 cm in diameter and recommended for a stereotactic biopsy, who underwent their diagnostic imaging work-up resulting in a biopsy recommendation at MD Anderson Cancer Center (MDACC) or at an outside facility with a technically acceptable quality of diagnostic mammography, and who are planning to have their stereotactic biopsy at MDACC. Age 25-85 years Willing to participate in the study, undergo an intravenous (IV) placement, able to undergo iodinated contrast injection, and able to provide informed consent  Exclusion Criteria:  Reported history of an allergic reaction to iodinated contrast History of anaphylactic reaction to any substance Renal insufficiency Pregnancy or lactation within 6 months Breast surgery affecting the site of interest within prior 6 months Breast biopsy at the site of interest within the last 2 months Mammographic mass or architectural distortion associated with the calcifications in question