Inclusion Criteria:  Diagnosis of moderate to sever facial acne vulgaris Facial IGA score of 3 (moderate) or 4 (severe) At least 20 and no more than 100 inflammatory lesions on the face No more than 100 noninflammatory lesions on the face. No more than 5 nodules (≥5 mm) on the face  Exclusion Criteria:  A subject with acne fulminans or conglobate or secondary acne will be excluded.