Inclusion Criteria:  Patients with clinical and genetic diagnosis of β-thalassemia major and intermedia Patients who showed partial response or a decline in response to hydroxyurea Patients who are not the candidates for the bone marrow transplant procedure.  Exclusion Criteria:  Married Patients Patients with comorbidities such as liver, cerebrovascular, cardiovascular, or kidney diseases Patients allergic to the drug ingredients Patients with mental disorders Patients who are enrolled in other clinical trials Patients with a history of venous or arterial thrombosis