Inclusion Criteria:  Patients with schizophrenia who meet the dsm-5 diagnostic criteria Aged from 18 to 55 Right-handedness, normal hearing, visual acuity or corrected visual acuity Written informed consent of the patient and his/her family All patients received MINI 7.0 structured interviews  Exclusion Criteria:  Patients who are currently taking clozapine or who have failed to respond to a full course of treatment with clozapine Current or past neurological illness,severe physical illness,substance abuse or addiction,alcohol dependence,mental retardation,pregnancy or lactation,extreme agitation, stupor, negative suicide,or those who can not cooperate Medically unstable for at least 1 month