Inclusion Criteria:  Patient's consent to share in the study Patients' age >18 years Patients with denovo acute myeloid leukemia  Exclusion Criteria:  Patients refusing to share in the study Non-Egyptian patients Patients' age < 18 years Pregnant women Patient's with other malignancies Patients with known congenital thrombotic/ hemorrhagic diseases Patients with Thrombotic Thrombocytopenic Purpura Patients with auto-immune diseases