Inclusion Criteria:  Patients with mild or moderate ulcerative colitis newly diagnosed by colonoscopy and biopsy according to Mayo endoscopic scoring of ulcerative colitis. Adults (males and/or females) with age range from 18 to 65 years old. Patients on treatment with 5-aminosalisylic acid (5-ASA)  Exclusion Criteria:  Patients with severe ulcerative colitis according to Mayo endoscopic scoring of ulcerative colitis. Treatment with systemic or rectal steroids. Treatment with immunosuppressants. Previously failed treatment with a sulphasalazine. Known hypersensitivity to any of study drugs. Hepatic and renal dysfunction. Pregnancy and lactation. History of colorectal carcinoma. History of complete or partial colectomy. Patients with diabetes mellitus Patients with history of lactic acidosis Patients with disease states associated with hypoxemia including cardiorespiratory insufficiency Positive stool culture for enteric pathogens, positive stool ova and parasite exam.