Inclusion Criteria:  Clinical diagnosis of advanced resectable colorectal cancer (Active stage III or IV) Histopathologically confirmed as adenocarcinoma Age 18 or over Being able to understand and sign the Informed Consent Form (ICF) Qualification for resection within 3 months from W0 or condition after primary tumor resection, not longer than 5 years from surgery  Exclusion Criteria:  Mucinous colorectal adenocarcinoma Canal and anal edge cancer, Adenocarcinoma of the appendix, Patients treated with neoadjuvant therapy or radiation therapy in the 3 months prior to study enrollment. Patients treated with systemic chemotherapy in the 3 months prior to study enrollment. Histopathological diagnosis other than adenocarcinoma Remission History of inflammatory bowel diseases Pregnancy HIV infection Active infection with hepatitis B and C viruses Leukocytopenia