Inclusion Criteria:  Age ≥ 18 years and able to give consent Severe aortic stenosis found eligible for transfemoral TAVI by the multi-disciplinary heart team Angiographic evidence of coronary artery disease with absence of coronary stents in at least one native coronary artery At least 30 mm of total NIRS-IVUS pullback length in sufficient quality for offline analysis of at least one native coronary artery with absence of coronary stents, containing at least one lesion requiring NIRS-IVUS imaging for clinical indications Written, informed consent by the patient or her/his legally-authorized representative for participation in the study In women with childbearing potential a negative pregnancy test is mandatory  Exclusion Criteria:  Age < 18years Any clinical contraindications to perform NIRS-IVUS ST-elevation myocardial infarction or cardiogenic shock within 48h prior to enrollment Decompensated aortic valve stenosis requiring emergency TAVI History of coronary artery bypass graft (CABG) Severe renal failure with estimated glomerular filtration rate <20 ml/min Malignancies or other comorbid conditions (resulting in a life expectancy <12 months) Inability to fully cooperate with the study protocol Known allergy towards P2Y12 receptor antagonists Pregnancy