Inclusion Criteria:  Index cases: patients with myeloproliferative or lymphoproliferative disorders. Controls: patients without hematological disease, without chemotherapy ((≤ 5 years.) and without immunosuppressive treatment at the study time. Age ≥ 18 y.o for all the patients  Exclusion Criteria:  Age < 18 y.o Pregnant or breastfeeding woman Patients deprived of their liberty by judicial or administrative decision.