Key Inclusion Criteria:  Criteria for patient inclusion in this study are as follows:  Male and female adults with SBS secondary to surgical resection of small intestine 18-75 years of age at the time of screening. Female patients must be postmenopausal (at least 2 years prior to dosing) or surgically sterile or agree to use an acceptable form of birth control from screening until 30 days after last dose. If oral contraceptives are used, patients must have been on a stable dose for ≥6 months. Male patients must agree to use an acceptable form of birth control during the study and for 30 days after the last dose. Male patients should not donate sperm for 90 days after last dose. At least 6 months since last surgical bowel resection. Patients may be on Parenteral Support [PS] (nutrition and/or fluid and electrolytes for at least some of their nutritional needs). If on PS, stable administration of PS volume for 1 month (±20% vol) prior to enrollment [stable administration of PS volume confirmed by Medical Monitor]. Able to ingest solid or semi-solid foods and drink.  Key Exclusion Criteria:  Criteria for exclusion from participation in this study are presented below. If there are any questions as to the inclusion or exclusion of a particular patient, please contact the study Medical Monitor.  Pregnancy or lactation Body mass index at screening <18 or >30 kg/m2 Clinically significant intestinal adhesions and/or chronic abdominal pain that can interfere with the conduct of the study Active Crohn's disease or IBD (as evaluated by standard procedures employed by the investigator/institution). If in remission, must be ≥12 weeks of remission prior to screening Inflammatory bowel disease patients who have NOT been on a stable drug treatment regimen for at least the past 3 months prior to screening Visible blood in the stool within the last 3 months Known heart failure or active coronary disease Alcohol or drug abuse within the last 12 months by history, or a disqualifying positive urine drug test at screening. Inadequate renal function as defined by serum creatinine <0.7 or >1.3 mg/dL (in men) and <0.6 or >1.1 mg/dL in women. Personal or family history of medullary thyroid cancer. History of pancreatitis Any use of growth hormone, or growth factors such as native GLP-2 or GLP-2 analog (teduglutide) within the last 3 months Use of antibiotics within the last 30 days Patient not capable of understanding or not willing to adhere to the study visit schedules and other protocol requirements