Inclusion Criteria:  Age 18 years or older Presence of an intraparenchymal lung lesion for which cryobiopsy is deemed the most appropriate method of biopsy Ability to provide informed consent  Exclusion Criteria:  Acute respiratory failure (defined as oxygen requirement > 4 L/min by nasal cannula above baseline, or need for any intervention to support ventilation and/or gas exchange for any duration, including invasive and non-invasive positive pressure ventilation, high-flow therapy, non-rebreather mask, or Venturi mask) Intensive care unit (ICU) admission Forced vital capacity (FVC) < 50% or diffusing capacity of the lung for carbon monoxide (CO) (DLCO) < 35% (if pulmonary function tests are available) Known or suspected pulmonary hypertension (defined as elevated right ventricular systolic pressure on echocardiogram, if available) Acute renal failure or chronic kidney disease Platelets < 100,000/uL International normalized ratio (INR) > 1.5 Use of anticoagulant therapy that cannot be held for 2 days Use of antiplatelet therapy (other than baby aspirin) that cannot be held for 5 days Any bleeding diathesis Pregnancy