Inclusion Criteria:  Age equal to or greater than 18 years. Need for hospitalization in ICU. At least 12 h of invasive mechanical ventilation Informed consent signed by legal representative and / or patient. Positive covid-19 diagnosis  Exclusion Criteria:  Known cognitive impairment before admission with short IQCODE (Informant Questionnaire on Cognitive Decline in the Elderly) Scores> 3.3 were excluded. Previous functional impairment, FAQ (Functional Activities Questionnaire) defined as > 6 points. Severe communication disorder and cultural limitation of language (language different from Spanish) Patient with limited therapeutic proportionality. Neurocritical patients (moderate-severe Traumatic Brain Injury / stroke of some kind / among others) Spinal injury or unstable fractures that limit mobilization