Inclusion Criteria:  In order to be eligible to participate in this study, a subject must meet all of the following criteria:  Male Age ≥ 40 years Undergo prostatectomy or TRUS-guided biopsy Provide signed Informed Consent  Exclusion Criteria:  A potential subject who meets any of the following criteria will be excluded from participation in this study:  treatment with any plant extract or 5a-reductase inhibitors during the last 3 months, history of pelvic radiotherapy, history of prostatectomy or transurethral resection of bladder tumor or previous TRUS-biopsy, presence of an indwelling catheter, prostate cancer found at the biopsy No symptoms (IPSS=0) No specimen is available (ablation/vaporization of the prostate)