Inclusion Criteria:  Signed informed consent form. Men and women aged 40-55. Body mass index <30 kg / m2. Level increase of one or several aging markers. Understanding of requirements for study participants, written consent to participate in the study (including volunteer's consent for his/her health information related to the study to be used and passed on) and to perform procedures outlined in study protocol. Negative pregnancy test for women of childbearing potential.  Non-inclusion Criteria:  Refusal to participate in the study. Any health conditions that, according to investigators, might prevent volunteers from participating in the study. Mental disorders, past medical history included. 10 + alcohol units per week (one alcohol unit equals 0,5 l of beer, 200 ml of wine or 50 ml of hard liquors) or any records of alcohol addiction. Drug addiction, chemical abuse. Pregnancy or breastfeeding. Past medical history of severe allergic reactions. General contraindications to plasmapheresis procedures. Any other health conditions or reasons that, according to investigators, might increase risks for participants or reduce the likelihood of results needed to meet the study goals.  Exclusion Criteria:  Voluntary refusal to participate in the study. Investigator doctor's decision on participant's exclusion for this participant's own benefit. Participant refuses to cooperate with investigator or is undisciplined. In case participant misses one or several study procedures or follow-up visits. Development of severe adverse reactions or severe diseases/conditions unrelated to the study, requiring withdrawal from therapy. Positive pregnancy test.