Inclusion Criteria:  Thyroid nodule requiring additional diagnostic follow-up (TI-RADS/Bethesda) Patients with thyroid problems requiring surgery (e.g. goiter) AeonoseTM measurement before undergoing cytological puncture or at least 3 days after cytological puncture pre-operatively. > 18 year. Signed informed consent  Exclusion Criteria:  Other underlying malignancy, (less than 5 years ago), basal cell carcinoma not included - Unable to participate due to comorbidities (e.g. COPD) Not able to understand the information