Inclusion Criteria:  men and woen over 18 years old and under 65 years old with multiple sclerosis 0-6 points in the expanded disability states scale (EDSS) with MS in remission (at least 6 months since the last relapse) able to understand and respect the protocol and its requirement who signed the consent prior to any other procedure protocol  Exclusion Criteria:  major patients under guardianship/curators/legal protection pregnant patients patients with contraindication for cryotherapy patients unable to complete the entire program patients with substantial change in pharmacological treatment the month before the start of the study