Inclusion Criteria:  Age ≥ 18 years Type II Diabetes mellitus Finding of obstructive coronary artery disease (≥50% stenosis in major epicardial vessel) and clinical indication of percutaneous coronary intervention.(PCI) Participant is willing to comply with all aspects of the protocol, including adherence to the assigned strategy, medical therapy and follow-up visits Participant is willing to give written informed consent  Exclusion Criteria:  Estimated glomerular filtration rate (eGFR) < 30mL/min/1,73m2 or dialysis Inability to comply with the protocol Urgent need for PCI Acute coronary syndrome within the previous 30 days Use of iodinated contrast or other nephrotoxic agents < 7 days Angina after coronary bypass surgery Canadian Cardiovascular Society Class IV angina, including unprovoked rest angina Life expectancy less than the duration of the trial due to non-cardiovascular comorbidity Pregnancy