Inclusion Criteria:  Body Mass Index (BMI) ≥ 18.0 and ≤ 30.0 kg/m Clinically normal medical history, physical findings, vital signs, ECG and laboratory values at the time of screening, as judged by the Investigator Dual user of snus and conventional cigarettes for ≥1 year, with a minimum weekly consumption of two or more snus cans and >5 cigarettes, and who is willing and able to use brands with nicotine content ≥1%  Exclusion Criteria:  History of any clinically significant disease or disorder Any clinically significant illness, medical/surgical procedure or trauma within 4 weeks of the first use of IP Positif for HIV, hepatitis B or C  After 10 minutes supine rest at the time of screening, any vital signs values outside the following ranges:  Systolic blood pressure <90 or >140 mmHg, or Diastolic blood pressure <50 or >90 mmHg, or Pulse <40 or >90 bpm Alcohol or drug abuse Use, or history of use of anabolic steroids Allergy/hypersensitivity to drugs with a similar chemical structure or class to nicotine Excessive caffeine consumption (daily intake of >5 cups) Female subjects who are pregnant or breastfeeding