Inclusion Criteria:  Male and female between 20 and 70 years of age. Patients diagnosed with benign goiter or thyroid cancer that will undergo open thyroidectomy (either unilateral or bilateral total thyroidectomy with or without central lymph node dissection). Naïve patients to thyroid surgery. Subjects are willing to comply with all aspects of the study and have signed informed consent form.  Exclusion Criteria:  Pregnant or lactating female patients. Presence of severe and uncontrolled illness such as stroke, hypertension, diabetes, chronic renal failure, coagulopathy, drug abuse. Patients with previous neck radiotherapy within 1 year. Concurrent diseases/conditions which will be unable to evaluate the outcomes. Patients receiving any adhesion prevention adjuvant. Previous history of Keloid or hypertrophic scar. Anticoagulant used within a week from surgery. Subjects are hypersensitive to sodium hyaluronate. Participate in another clinical trial within 1 month. Patients presence of surgical site infection. Patients are with abnormal clinical test (appendix 1) result within one month or ECOG performance status (appendix 2) score ranged from 3-4.