Inclusion Criteria:  cT1b-T4b (cT4b - invasion in diaphragm, parenchyma of liver, spleen, pancreas, abdominal wall, small bowel, colon, distal part of splenic artery) cN0-3 M0 Age: 18 - 80 ECOG: 0 - 1 Histological type: adenocarcinoma Differentiation grade: G0 - G4 No previous surgery No previous chemotherapy No concomitant severe comorbidity Written informed consent  Exclusion Criteria:  cT1a, cT4b (invasion in truncus, hepatic artery, proximal part of splenic artery) Presense of distant metastases ECOG: 2 - 5 Age: <18 and >80 Severe concomitant comorbidity