Inclusion Criteria:  Patients having been investigated with a suspected hematological disorder and: Having unclear diagnosis after internal routine diagnosis Unusual clinical course Unusual r/r status or non-responder Multiple parallel hematological conditions Difficult/rare therapy associated/secondary neoplasms Current diagnostic workup is not satisfactory in terms of (1) accuracy (2) clinical behavior Only samples of patients min. 18 years of age will be used Material with a minimum of 20% tumor content in bone marrow or peripheral blood sample Patient´s informed consent  Exclusion Criteria:  Sample is not fit for state-of-the-art diagnosis, fails initial quality control. For quality insurance we will exclude samples with wrong anticoagulant sent. Samples with damage due to meteorological reasons (freeze-thaw damage or elevated temperature) will be excluded. Samples with to scarce material jeopardizing routine gold-standard diagnosis will be excluded (tumor content < 20 %).