Inclusion Criteria:  type 2 diabetes therapy including at least metformin 1000 mg and sulphonyl urea at least half of the maximal dose BMI > or = 30 kg/m2 HbA1c < or = 8,5% associated risk factors including smoking, dyslipidaemia, arterial hypertension, chronic kidney disease stage 1 to 3.  Exclusion Criteria:  therapy with injectable GLP-1 receptor agonist ongoing or was taking place in the last year manifested cardiovascular disease heart failure chronic kidney disease stages 4 and 5 advanced liver disease proliferative retinopathy or maculopathy