Inclusion Criteria:  18 years or older  Apply one of the following  Chronic abdominal pain for at least 4 weeks, min. 3/10 points on a visual pain scale Persistent diarrhea, Stool frequency of at least 4 per day doctor visit due to the mentioned complaints Exclusion of an infectious genesis or coeliac disease by serological testing or duodenal biopsy, if necessary Consent to study participation Fecal calprotectin > 50 µg/g  Exclusion Criteria:  Pregnancy metastasized malignoma terminal renal insufficiency, renal insufficiency requiring dialysis swallowing disorder age < 18 years lack of consent infectious genesis of symptomps coeliac disease  Relative contraindication:  evidence of strictures, strictures or fistulas in the gastrointestinal tract in imaging or in high suggestive symptoms, e.g. Ileus