Inclusion Criteria:  Age more than 18years scheduled for cardiac surgery and requiring CPB Surgery with total cross clamp time more than 60 min (Aortic valve surgery, double valve, CABG)  Exclusion Criteria:  Allergy to tranexamic acid or any of the lysine analogues History of seizure Chronic homeostasis abnormality, platelet <100000/cumm PT>20sec INR>2 On anticoagulant Severe chronic kidney disease with creatinine clearance less than 30ml/hr Deranged liver function test Total cross clamp time less than 60 min