Inclusion Criteria:  Over 18 years old Any gender. Patients with solid pancreatic lesions evidenced by CT or MRI who do not have a histopathological diagnosis.  Exclusion Criteria:  That no lesion in the pancreas is identified by EUS. Pancreatic lesions with a cystic component. Alteration of coagulation parameters (INR> 1.5, Platelets <50,000 / mm3) or having taken antiplatelet agents or oral anticoagulants one week prior to the biopsy. History of acute pancreatitis in the last 4 weeks. Pregnant Refusal or inability to sign informed consent