Inclusion Criteria:  Age 18 years or above Ability to provide informed consent  Exclusion Criteria:  Pregnancy or breastfeeding at the time of planned recruitment History of significant renal (eGFR<30) or hepatic impairment (AST or ALT >two-fold above ULN; pre-existing bilirubinaemia >1.2 ULN) The investigators will retain the right not to recruit potential participants with severe health disorders which may impact on their ability to participate in the study; these may include, but are not limited to, metastatic cancer, severe cardio-respiratory disease or other life-limiting health disorders Participants who have participated in another research study involving an investigational medicinal product in the 12 weeks preceding the planned recruitment Glucocorticoid use via any route within the last six months Current intake of drugs known to impact upon steroid or metabolic function or intake of such drugs during the six months preceding the planned recruitment Use of combined oral hormonal contraception in the three months preceding the planned recruitment