Inclusion Criteria:  Age>18 At least 3 month post transplantation  Exclusion Criteria:  pediatric recipients Active covid infection at the time of the study Pregnancy Allergy to any ingredients included in the vaccine Lactation in first six month of delivery Active Acute cellular rejection proven by liver biopsy Acute Febrile state with either leucopenia or leucocytosis High dose of corticosteroid at study timing (pulse methyl prednisolone)