Inclusion Criteria:  18-65 years old; Nmosd was diagnosed according to wingerchuk standard revised in 2015, MS was diagnosed according to McDonald standard revised in 2017, and 100 normal people were diagnosed; In the acute stage, within 1 month of the onset or stable stage, there was no GD enhanced lesion on MRI, and EDSS score had no significant change within 6 months, which was more than 1 month from the last attack; MRI examination was complete: baseline, 6 months, 1 year, 2 years; Sign informed consent.  Exclusion Criteria:  The course of disease was more than 30 years; History of brain injury or spinal cord injury; History of central nervous system infection or immunodeficiency syndrome; HBV, HCV patients, syphilis, HIV-1, HIV-2 patients; Suffering from mental illness; Pregnant and lactating women or patients planning to conceive within one year; Unable to cooperate to complete the follow-up due to geographical or other reasons; Patients also participated in other randomized controlled trials.