Inclusion Criteria:  Patients with dyslipidemia and statin intolerance, defined as:  Use of 2 or more statins and intolerance of these drugs in any dose or inability to tolerate dosage increasement beyond a maximum weekly dose of 70 mg atorvastatin, 140 mg Simvastatin, pravastatin, or lovastatin, 35 mg rosuvastatin, 280 mg of Fluvastatin and symptoms improve or disappear when statin is reduced in dosage or discontinued  Participants are ≧ 18 years old Written declaration of consent is available The patient is cognitively, linguistically and organizationally capable to meet the study requirements. The possibility of 1 year follow-up is very likely.  Exclusion Criteria:  Use of any experimental or investigational drugs within 30 days prior to screening. An employee or contractor of the facility conducting the study, or a family member of the principal investigator, co-Investigator, or sponsor.