Inclusion Criteria:  Age from 55 and 80 year Both male and female patients. Participants will need to have had knee pain for at least 6 months and experience current average pain of at least 3 (on an 11-point Numerical Pain Rating Scale (NRS) Patients having no other physical and mental illness. Osteoarthritis of knee (Stage-II) by kallgren and lawrence scale  Exclusion Criteria:  Patients with lab results abnormal (malignancy) Nonmusculoskeletal conditions Patient's undergone surgery of knee. Other than osteoarthritis