Inclusion Criteria:  Provision of signed and dated informed consent form Resistant hypertension is defined as casual blood pressure during clinical examination of more than 140/90 mmHg despite treatment with optimal or best-tolerated doses of three or more drugs, which should include a diuretic, typically an angiotensin converting enzyme (ACE) inhibitor or an angiotensin receptor blocker (ARB), and a calcium channel blocker (CCB) (or beta blocker). All reference blood pressures will be taken as a mean of the 2nd and 3rd measurements in physician's office during a single examination, measured at least 3 min apart Aged 18 years or above Inadequate control of hypertension is confirmed with home blood pressure monitoring (average of morning and evening measurements after 5 minutes of relaxation in sitting position, for 6 days)  Exclusion Criteria:  Pregnancy, anticipated pregnancy, or breastfeeding Incarceration or institutionalized living which may prohibit measurement of home blood pressure Participation in another intervention study that may affect blood pressure Patients in whom systolic blood pressure is not measurable (e.g. those with left ventricular assist devices) Hypotension: average systolic blood pressure <100 mmHg over last 2 weeks prior to screening while not taking any blood pressure medications Life expectancy <4 months Anticipated living donor kidney transplant within 4 months Patients with a systolic blood pressure value over 220 mmHg requiring immediate adjustments of therapy Patients with moderate to severe renal insufficiency (acute or chronic) with glomerular filtration rate of less than 30 ml/min Patients with active bronchospastic disorders Heart failure classes III and IV Severe bradycardia (heart rate below 50/min), 2nd and 3rd degree AV block Patients with a history of hypersensitivity to any of the drugs under study Patients already using add-on therapy