Inclusion Criteria :  Have a signed informed consent form before any study-specific procedures are performed; Have DME with presence of intraretinal and/or subretinal fluid in the study eye, with central subfield thickness (CST) of ≥310 µm (may be adjusted based on gender specific requirements) by SD-OCT at screening (Visit 1) (as assessed by an independent reading center); CST is not part of the eligibility reconfirmation on Day 1 Have a documented diagnosis of type 1 or type 2 diabetes mellitus and a glycosylated hemoglobin A1c (HbA1c) of ≤ 12.0% (≤108 mmol/mol) at Visit 1 (Screening).  Exclusion criteria:  1) Have macular edema considered to be because of a cause other than DME.