Stratum I: germinoma  Inclusion Criteria:  3 years ≤ age ≤ 30 years Newly diagnosed Unilateral basal ganglia/thalamus lesion Germinoma：Histologically confirmed; and/or serum and/or CSF beta-HCG elevation (≤50IU/L); AFP negative No radiological evidence of additional lesions in the CNS Negative CSF cytology test Adequate organ function Written informed consent  Exclusion Criteria:  Bilateral basal ganglia/ thalamus lesions Synchronous pineal or sellar/suprasellar lesion Diabetes insipidus With extracranial lesion(s) Serum/CSF β-HCG >50IU/L without histology Mature teratoma with normal tumor markers Inadequate organ function Poor compliance  Stratum II: non-germinomatous germ cell tumors  Inclusion Criteria:  3 years ≤ age ≤ 30 years Newly diagnosed Unilateral basal ganglia/thalamus lesion NGGCTs: Histologically confirmed; and/or serum and/or CSF AFP elevation; beta-HCG≥500IU/L No radiological evidence of additional lesions in the CNS Negative CSF cytology test Adequate organ function Written informed consent  Exclusion Criteria:  Bilateral basal ganglia/ thalamus lesions Synchronous pineal or sellar/suprasellar lesion Diabetes insipitus With extracranial lesion(s) 50IU/L<serum/CSF β-HCG <500IU/L without histology Mature teratoma with normal AFP and β-HCG <500IU/L Inadequate organ function Poor compliance