Inclusion Criteria:  Age > 18 years relapsed multiple myeloma, at least one prior line of treatment treatment with carfilzomib validated in a multidisciplinary consultation meeting and accepted by the patient The patient accepts mixed management and benefits from the support of his/her family and friends (see ANAES 2003 criteria). If the patient does not have a caregiver, he/she can still participate in the research and the absence of a caregiver will be collected. Patient capable of adhering to care (cf. ANAES 2003 criteria) Patient affiliated to a social security system or beneficiary of such a system. Patient having received full information on the organization of the research and having signed his or her informed consent  Exclusion Criteria:  Person with a contraindication to carfilzomib Women of childbearing age who do not have effective contraception Persons referred to in articles L. 1121-5, L. 1121-7; L1121-8 and L1122-1-2 of the Public Health Code Pregnant woman, parturient or nursing mother Minor (not emancipated) Adult person under a legal protection measure (guardianship, curatorship, safeguard of justice) A person of full age who is unable to express his or her consent