Inclusion Criteria:  Patient is 1 month to </= 18 yrs of age Admitted to Shriners Hospitals for Children Northern California Patient has a third degree burn >/= 20 % total body surface area (TBSA)  Exclusion Criteria:  Infants < 5 kg  Pregnancy  18 years of age Inability or unwillingness to receive blood products Pre-existing need for hemodialysis Brain death or imminent brain death Non-survivable burn as determined by the attending burn surgeon Pre-existing hematologic disease Closed head injury with Glasgow Coma Score <9