Inclusion Criteria:  Pancreatic adenocarcinoma proven histologically or cytologically in favor of pancreatic adenocarcinoma Mesurable disease according to RECIST 1.1 criteria or non measurable disease Metastatic disease (synchronous or metachronous) or locally advanced / borderline deemed unresectable and / or patient inoperable due to his co-morbidities and / or local recurrence after surgery Thrombosis of the main portal vein and/or of one of its branches (endo-luminal defect on the injected CTscan) of cruoric or tumoral origin or circumferential stenosis of the portal vein trunk, the spleno-mesaraic confluence or one of its venous branches with or without signs of portal hypertension on CTscan and / or upper GIendoscopy  Exclusion Criteria:  - Post-surgical portal vein thrombosis and / or in patients considered in remission Non-adenocarcinomatous pancreatic tumor (endocrine, etc.)