Inclusion Criteria:  Diagnosis of osteoarthritis according to the clinical and radiographic criteria of the American College of Rheumatology. Pain score of at a minimum of 50 mm on a VAS scale of 0-100 mm  Exclusion Criteria:  Presence of a previous cardiovascular event in the last 6 months. History of liver or kidney disease. Presence of medical condition requiring chronic treatment with drugs or other substances. Excessive alcohol consumption (> 20 g/day) or substance abuse. Presence of intolerance or hypersensitivity to the food supplement or to any of its components in isolation. Use of any intra-articular injection in the anatomical area under study in the last 6 months. Treatment with symptomatic slow-acting osteoarthritis drugs (SYSADOA) in the last 3 months. Criteria listed in the Clinical Investigation Guideline for medicinal products used in the treatment of osteoarthritis published by the European Medicines Agency of the European Union in 2010 and radiographic osteoarthritis grade 4 according to the Kellgren-Lawrence classification system. Any condition that, in the opinion of the investigators, would disqualify the subject from participation in the study.