Inclusion Criteria:  Age >/= 18 years old. Breast cancer diagnosis histologically proven and pathology report from breast and ipsilateral axillary nodes. Pathology: invasive carcinoma. Staging: tumor size >2cm (>/=T2), node positive (N >/= 1), i.e. >/= T2N1; from stage IIB to stage IIIC, according to AJCC breast Cancer staging 8th edition. (Giuliano, Edge and Hortobagyi, 2018) All subtypes are included, either HR (ER, PR) positive or negative, HER2 positive or negative. Neoadjuvant systemic treatment composed of anthracyclines-based chemotherapy and taxanes, trastuzumab for HER2 positive patients  Exclusion Criteria:  Metastatic breast cancer inflammatory breast cancer, male breast cancer, bilateral breast cancer, or concurrent malignancy Previous malignancy. Presence of any contraindication to neoadjuvant treatment