Inclusion Criteria:  The patient has repeated knee joint pain in the past month; X-ray film (standing position or weight-bearing position) shows narrowing of the joint space, subchondral bone sclerosis and/or cystic degeneration, and osteophyte formation on the joint edges; Age ≥50 years old; Morning stiffness time ≤30min; There is bone friction sound (sensation) during activity.  Patients who meet the diagnostic criteria 1 + (any 2 of 2, 3, 4, 5) can be diagnosed as KOA.  Exclusion Criteria:  Patients who do not meet the diagnostic criteria for knee osteoarthritis