Inclusion Criteria:  Patients presenting with anterior circulation acute ischemic stroke Patients aged between 18-80 years. CTA or DSA verified arterial occlusion of ICA, M1 or M2. NIHSS on admission 4 - 26 Baseline CTP verified infarct core < 70 ml, penumbra > 10 ml, hypoperfusion/core > 1.8 Undergoing mechanical thrombectomy within 24 hours of stroke onset. For wake-up stroke, the onset time is determined as the midpoint of last-seen-well and discovered time  Exclusion Criteria:  Patients without recanalization (TICI 0,1, 2a) Pre-existing neurological disability (a score greater than 2 on the mRS) Contraindication of edaravone dexborneol