Inclusion Criteria:  refractory AML (no remission after 2 induction therapy, relapsed AML within 6 months of first complete remission (CR), relapse AML no CR after reinduction therapy), multiple relapse and refractory relapse AML patients with HLA matched related or unrelated donor (9~10/10) or haplo-identical related donor  Exclusion Criteria:  Patients with poor liver function (enzyme >2N or bilirubin >2N) poor renal function (Scr >1.5N) poor cardiac function （EF<45%） inform consent not provided