Inclusion Criteria:  Informed Consent as documented by signature Good oral and general health  Exclusion Criteria:  Women who are pregnant or breast feeding Intention to become pregnant during the course of the study Systemic disease Previous enrolment into the current study Clinically diagnosed severe oral lesions Use of antibiotics and topical oral probiotics within the 3 months preceding the study or during the study Dental treatments and use of oral disinfectants within 30 days preceding the study or during the study