Inclusion Criteria:  Clinical diagnosis of Premature Ovarian Failure Patients show no response to drug treatment Willing to receive follow up Willing to conceive a baby Age between 18 to 39  Exclusion Criteria:  Patients with chromosome abnormalities Patients with congenital ovarian malformations Patients with severe endometriosis Patients with thyroid dysfunction Patients with pregnancy contraindications Patients with hormone replacement therapy contraindications Past history of ovarian tumors or after radiotherapy Can not take the follow-up, or want to take other treatment during the follow-up period Patients with immune system diseases