Inclusion Criteria:  Age 18-65 years old; Pathologically confirmed non-keratinizing nasopharyngeal carcinoma; Stage T3-4N0-1 (according to the UICC/AJCC 8th); No distant metastasis; Have not received anti-cancer treatment in the past; ECOG (Eastern Cooperative Oncology Group of the United States): 0-1; Adequate hematologic, hepatic and renal function.  Exclusion Criteria:  The purpose of treatment is palliative; Diagnosed with other malignant tumors at the same time; Malignant tumor history; Pregnancy or breastfeeding, or expect to become pregnant during the clinical trial period; Combined serious illness.