Inclusion Criteria:  Age> 18 years and smokes at least 1 cigarette daily Hospitalized with an acute cardiovascular event (i.e. myocardial infarction, unstable or stable angina, arrythmias, carotid stenosis or claudication with need for revascularization) Sign informed consent and is expected to participate according to ICH / GCP  Exclusion Criteria:  Does not usually live or work in the Vestre Viken catchment area Chronic renal failure stage 4 or known allergic reaction to varenicline Any condition (e.g. psychosis, alcohol abuse, dementia) or situation that may pose a significant risk to the participant, confuse the results or make participation unethical Lack of Norwegian and English knowledge Short life expectancy (<12 months)