Inclusion Criteria:  Adults (aged 18 years old or older) Able to consent Receive HIV care at the HIV Department of the Brighton and Sussex University Hospital (Lawson Unit/Elton John Centre) All genders, sexual orientations, and socio-economic groups are eligible for participation On one of the following therapies  Control population  Juluca (DTG/rilpivirine[RPV]) Boosted darunavir plus lamivudine (DRV/r or DRV/c + 3TC) Boosted darunavir plus raltegravir (DRV/r or DRV/c + RAL) A triple regimen (2 nucleos(t)ide reverse transcriptase inhibitors [NRTIs] + 1 InSTI; 2 NRTIs + 1 non-nucleoside reverse transcriptase inhibitor [NNRTI]; 2 NRTIs + boosted protease inhibitor [PI/b])  Target population  DTG/3TC  Exclusion Criteria:  Patients taking off-label drug combinations due to complex HIV resistance patterns. ART naïve or individuals declining ART will be excluded. Patients without access to the technology to participate in the online study will be given the option to participate in person (following COVID-19 guidance), and if this is not possible they will be excluded.