Inclusion Criteria:  Age more than 18 years old regardless of gender. Platelet count below 100000/cu mm. Confirmed diagnosis aplastic anaemia. Confirmed diagnosis immune thrombocytopenia  Exclusion Criteria:  Patient who received a platelet or blood transfusion within two weeks prior MPV analysis. Splenectomized patients Patients with chronic infection or inflammations. Diabetics and patients with coronary artery disease. Patients on anti- platelet or anti-inflammatory drugs.