Inclusion Criteria:  Patient receiving a comprehensive information about the study, and not opposed to participate  + one criterion among :  patient hospitalized fo a COVID-19 Patient with known APS Patients hospitalized for an acute venous thromboembolism event aPL positivity or COVID-19 healthy volunteers  Exclusion Criteria:  For all participants : pregnancy, age below 18 years-old, absence of written informed consent , autoimmune or inflammatory disease except antiphospholipid syndrome For patients with COVID-19: previous aPL positivity (before COVID-19 infection) For patients with APS: previous symptomatic COVID-19 infection For patients control with acute venous thromboembolism event: previous symptomatic COVID-19 infection, infection or inflammatory disease in flare at the time of thromboembolism event, known aPL positivity For Healthy volunteers: history of thrombosis (venous, arterial or small vessels), previous symptomatic COVID-19 infection, infection or inflammatory disease in flare at the time of inclusion, known aPL positivity