Inclusion Criteria:  Subjects seeking medical care for two or more of the following signs/symptoms of pharyngeal streptococcal infections:  pharyngeal pain [with or without swallowing], tonsillar swelling with exudates, pharyngeal erythema, tender cervical lymphadenopathy, fever. Subjects who have not received antibiotic treatment within the past 14 days. Subjects (or their parents/guardians) provide written informed consent/assent to participate in the study  Exclusion Criteria:  1. Lay users who are accompanying patients are unwilling/unable to collect throat swab sample from a child or adult.