Inclusion Criteria:  Is a male or female subject ≥ 5 years of age with venomous snakebite and must present with an initial SSS of  2 points in any SSS category other than gastrointestinal and 1 or more additional points in any other SSS category other than gastrointestinal or ≥ 3 in any SSS category other than gastrointestinal.  SSS scoring should be performed for inclusion assessment without waiting for receipt of Baseline hematological laboratory results. Gastrointestinal scores should not be used for inclusion.  Index event (snakebite) must be symptomatic and must have occurred within 8 hours of first treatment. Is willing (or legally authorized representative is willing) to provide informed consent prior to initiation of any study procedures.  Exclusion Criteria:  Has received antivenom treatment for envenoming prior to enrollment in this study. Is considered by the investigator to have a clinically significant upper GI bleed evidenced by hematemesis, "coffee-ground" emesis or nasogastric aspirate, or hematochezia thought to originate from upper GI tract. Has history of cerebrovascular accident or intracranial bleeding of any kind, acute coronary syndrome, myocardial infarction, or severe pulmonary hypertension. Has known history of inherited bleeding or coagulation disorder. Is, at Screening Visit, using the following anticoagulants: warfarin/coumadin, argatroban, bivalirudin, lepirudin, apixaban, dabigatran, clopidogrel, prasugrel, ticlopidine or another anticoagulant agent not specifically listed, or has used heparin, enoxaparin, fondaparinux, or other low molecular weight heparin or antiarrhythmic drugs within 14 days prior to treatment. Has a history of chronic liver disease such as chronic active viral hepatitis, alcohol-related liver disease, non-alcoholic steatohepatitis, non-alcoholic fatty liver disease, hemochromatosis, primary biliary cirrhosis, primary sclerosing cholangitis, or autoimmune hepatitis. Reports or has known pre-existing renal impairment or chronic kidney disease (defined as Stage 4 or receiving dialysis or hemofiltration). Has a known allergy or significant adverse reaction to varespladib-methyl or related compounds. Is considered by the Investigator to be unable to comply with protocol requirements due to geographic considerations, psychiatric disorders, or other compliance concerns. Is pregnant, has a positive serum human chorionic gonadotropin (hCG) pregnancy test or not willing to use a highly effective method of contraception for 14 days after initial treatment, or is breast-feeding.