Inclusion Criteria:  Able and willing to sign the Patient Consent Form and adhere to study visitation schedule antral follicle count (AFC) <20 Anti-Mullerian hormone (AMH) ≤3ng/ml (AMH result of up to one year will be valid) Age >=18 and ≤40 years BMI >18 and <30 kg/m2  Exclusion Criteria:  Medically indicated fertility preservation AFC ≥ 20 Polycystic ovarian syndrome (PCOS) according to the Rotterdam criteria FSH ≥ 20 History of untreated autoimmune, endocrine or metabolic disorders Contraindication for hormonal treatment Recent history of severe disease requiring regular treatment (clinically significant concurrent medical condition that could compromise subject safety or interfered with the trial assessment).