Inclusion Criteria:  Adult patient hospitalized in the Georges Pompidou European Hospital medical ICU Patient with or without SARS-CoV-2 infection ECCO2R treatment decision made by the medical team (regardless of the FLOW-ECCO2R protocol): mainly ECCO2R to enable ultraprotective ventilation for Acute respiratory distress syndrome (ARDS) patients or to avoid intubation or to shorten invasive mechanical ventilation in Chronic obstructive pulmonary disease (COPD) patients Affiliation to a social security regimen Informed consent (patient, trusted person, close family) , by default emergency inclusion notified in medical file and pursuance consent sought Negative serum or urinary β-hCG for women of child-bearing potential  Exclusion Criteria:  Known allergy to heparin or to any of the excipients of the specialty used History of type II heparin-induced thrombopenia Thrombocytopenia (platelet < 100.000/mm3) Constitutional hemostasis disease interfering with biological assays Organic lesion likely to bleed Bleeding manifestations or tendencies linked to disorders of hemostasis Intracerebral hemorrhage Participation in another interventional research involving human participants Pregnant or breastfeeding women Protected adults (including individual under guardianship by court order) Persons deprived of their liberty by judicial or administrative decision