Inclusion Criteria:  Conformed to the diagnostic criteria of diabetic nephropathy No gender limitation, age 18-65 years old, no fertility requirement temporarily eGFR: 30~90ml/min/1.73m2（CKD-EPI） Urine protein >1 g/day No glucocorticoids or/and immunosuppressive therapy was received within 3 months Patients volunteered to participate in this study and signed the informed consent  Exclusion Criteria:  Combined with diabetic acute complications or acute kidney injury (AKI) Combined with other autoimmune diseases Primary and other secondary renal diseases Patients with hypotension (BP < 90/60mmHg) or bilateral renal artery stenosis who are not suitable for angiotensin receptor blockers (ARB) drugs There are contraindications to the use of kunxian capsules or allergic to any of the ingredients in kunxian capsules There are fertility requirements or pregnant, lactation patients Combined with malignant tumor, hepatitis, tuberculosis, HIV, serious infection, rheumatic disease, heart failure, chronic obstructive pulmonary disease (COPD) and other serious systemic diseases Kidney transplant or dialysis has been performed Clinicians deem it inappropriate, or patients are unwilling to sign informed consent, have poor compliance, have a history of mental illness, or cannot complete follow-up visits