Inclusion Criteria:  Between ages 18-70 years Must be willing to undergo major facial reconstruction Be able to understand the pre and post-transplantation evaluation, physical therapy, and follow up procedures Conventional reconstruction deemed unsatisfactory  Exclusion Criteria:  Medically unable to provide consent Active infections such as Human Immunodeficiency Virus, mycobacteria, hepatitis B, and hepatitis C Recent history of alcohol or IV drug or chemical dependency Psychiatric evaluation that indicate mental instability or non-compliance Cognitively impaired and Terminally ill Women of child bearing age with intent to conceive, pregnant or lactating Unable to receive immunosuppression after transplantation because of either geographic or financial limitations End stage organ disease (renal failure, Congestive Heart Failure (CHF), Chronic Obstructive Pulmonary Disease (COPD), etc.) Chronic infections such as osteomyelitis