Inclusion Criteria:  Patients with recurrent and recalcitrant cutaneous and anogenital warts.  Exclusion Criteria:  History of allergy to the HPV vaccine Active viral, fungal, or bacterial infections Immunosuppressive diseases or drugs. Autoimmune diseases, or other systemic diseases, e.g., hepatic, or renal disorders, diabetes, meningitis or convulsions Skin allergies Pregnancy and lactation Earlier wart treatment at least one month before enrollment.