Inclusion Criteria:  Patients with a diagnosis of heart failure and who have been on a stable dose of a diuretic for at least 30 days. Plan for a daily outpatient oral loop diuretic regimen with anticipated need for long term loop diuretic use ≥ 18 years of age Signed informed consent  Exclusion Criteria:  End-stage renal disease requiring dialysis therapy Inability or unwillingness to comply with the study requirements History of heart transplant or actively listed for heart transplant Implanted left ventricular assist device or implant anticipated <3 months Pregnant or nursing women or women who are trying to conceive Malignancy or other non-cardiac condition limiting life expectancy to <12 months Known hypersensitivity to furosemide, torsemide, or related agents