Inclusion Criteria:  Diagnosis of sickle cell disease based on hemoglobin electrophoresis Provision of signed and dated informed consent form Able to speak and understand English Chronic pain defined as a response of "Most days" or "Every day" to the question, "In the past 3 months, how often have you had pain?" (Answer options: Never, Some days, Most days, Every day) Current pain interference using the general activity question from PEG, score ≥3 on 0-10 scale  Exclusion Criteria:  Has had a stem cell transplant for sickle cell disease A known diagnosis of moderate or severe opioid use disorder by Diagnostic and Statistical Manual of Mental Disorders-5 criteria Current incarceration Patients who are on a chronic transfusion/exchange program Any other condition that the investigator considers precludes participation in the clinical trial