Inclusion criteria:  Over 18 years old Hospitalization in the Department of Emergency Psychiatry and Acute Care (Montpellier University Hospital) between 2012 and 2019 Having being enrolled in one the department's clinical studies between 2012 and 2019 Moderate to severe characterized depressive episode according to DSM-5 diagnostic criteria (severity assessed with BDI, IDSC-30 and QIDS)  Exclusion criteria:  Protection by law (guardianship or curatorship) Deprivation of liberty (by judicial or administrative decision) Bipolar disorder