Inclusion Criteria:  meets the diagnostic criteria of acute cerebral infarction established by Neurology Society of Chinese Medical Association, and confirmed by cranial Magnetic Resonance Imaging； Time from onset to enrollment ≤14 days; Volunteer to participate in the study and sign the informed consent.  Exclusion Criteria:  Silent cerebral infarction with no symptoms and signs; Complicated with post-infarction hemorrhage; Cerebral hernia and other complications caused by massive cerebral infarction may lead to death in acute phase; Cardiogenic cerebral embolism caused by atrial fibrillation; Cerebral infarction caused by tumor, vasculitis and other special reasons; Complicated with serious systemic diseases, including liver and kidney insufficiency, respiratory failure, heart failure, infection, etc