Inclusion Criteria:  Age during 18-45y; Women tested for TPOAb and/or TgAb, TSH, free T3, free T4, total T3 and total T4 during the 1st trimester of pregnancy  Exclusion Criteria:  Multiple pregnancies; Age < 18 y or > 40 y; L-T4 or PTU intervention before pregnancy; Other autoimmune diseases.