Inclusion Criteria:  Age >18 years Both genders Diagnosis of non-m3 AML by the WHO 2016 diagnostic criteria Patients eligible and not eligible for transplant AML secondary to treatment or associated to myelodisplasia  Exclusion Criteria:  AML with PML/RAR-alfa translocation t(15;17) Central nervous system involvement Poor functional status (ECOG>2) Organic dysfunction (Marshall score ≥2) Active infection Use of other CYP3A4 inhibitors Pregnancy GFR <30 ml/min/1.72m2