Inclusion Criteria:  Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) Glomerular Filtration Rate (eGFR) 20 to <45 mL/min/1.73m^2 Body Mass Index ≥ 27 kg/m^2 Six minute walk distance ≥ 300 m and < 600 m Able to perform resistance training  Exclusion Criteria:  Clinical history of Type 1 or Type 2 Diabetes Mellitus Screening hemoglobin A1C ≥ 6.5% Potential contraindications to semaglutide such as a history of pancreatitis, family or personal history of multiple endocrine neoplasia type 2 or familial medullary thyroid carcinoma Previous bariatric surgery Use of medications that cause clinically significant weight gain or loss Medical condition likely to limit survival to less than 1 year Anticipated start of dialysis or kidney transplantation within 6 months Any factors judged by the investigator or study team to likely limit adherence to interventions Vulnerable populations, including pregnant or incarcerated subjects Currently enrolled in interventional clinical trials using drugs or devices Recent hospitalizations or major interventional procedures done within the past 60 days