Inclusion Criteria:  premenopausal adult women diagnosis of acute uncomplicated cystitis (with the symptoms of dysuria, increased frequency, and urgency of urination and lower abdominal pain (suprapubic pain), that is presumed to be confined to the bladder; with no signs or symptoms that suggest an upper tract or systemic infection) a sum-score of of ≥6 for the typical uncomplicated urinary tract infections symptoms (frequency, urgency, painful urination, incomplete emptying, suprapubic pain, and visible hematuria) reported on the Acute Cystitis Symptom Score (ACSS) typical domain and pyuria (10 white blood cells/mm3 in a mid-stream specimen) at day 0  Exclusion Criteria:  any renal disease upper urinary tract infection malformations of the urinary tract congenital disorders of the urinary tract catheter use pregnancy breastfeeding self-medication with bearberry or antibiotic use in the last 3 months 5 or more bearberry treatments in the previous year concomitant use of other antibiotics and NSAIDs contraindication for study drugs active malignancy immunodeficiency, including immunosuppressive treatment.