Inclusion Criteria:  voluntarily participated and signed the informed consent form in writing is 18-70 and gender unlimited histologically proved to be squamous cell carcinoma as AJCC(version 8): -A, ⅣB head and neck squamous carcinoma unable or denied surgery; ~ A, ⅣB squamous carcinoma of the head and neck with the following postoperative risk factors: positive or proximal resection, lymph node envelope invasion, nerve and vascular invasion, primary focal pT3 or T4, N2 or N3 lymph node lesions. card score ≥ 70 survival is expected to be ≥ for 6 months fertility women should guarantee contraception during entering the study Hemoglobin (HGB) ≥ 100 g/L, leukocyte (WBC) ≥ 3.5 × 10^9 / L*(unit normal), Platelet (PLT) ≥ 100 × 10^9 / L(unit normal), neutrophil (WBC) ≥ 1.5 × 10^9 / L*(unit normal) liver function: 2.5 times of the upper normal limit (ULN), gluten transaminase (ASAT) <; total bilirubin <1.5 × ULN renal function: Serum creatinine <ULN, endogenous creatinine clearance (Ccr) ≥ 55 ml/min has no severe complications such as hypertension, diabetes, coronary heart disease, and psychiatric history (no history of head and neck radiotherapy or chemotherapy within 3 months)  Exclusion Criteria:  has a distant transfer has received epidermal growth factor targeted or immunotherapy has developed other malignant tumors (except for cured basal cell carcinoma or cervical carcinoma in situ) pregnant women or lactating women and women of childbearing age who refuse contraception during the treatment observation period has a serious history of severe allergies or abnormalities refused or cannot sign an informed consent to participate in the trial substance abuse or alcohol addicts