Inclusion Criteria:  Have a diagnosis of cancer Be receiving neurotoxic chemotherapy or have completed neurotoxic chemotherapy in the past nine months (i.e., taxane-, platinum-, vinca alkaloid-, epothilone-, or proteasome inhibitor-based chemotherapy) Report two or more symptoms of CIPN at a level of >= 4 on the CIPN symptom inventory on the Screening Form Have an Eastern Cooperative Oncology Group (ECOG) performance status 0-1 Have at least six months life expectancy Be at least 18 years of age Be able to read and understand English Be able to provide written informed consent  Exclusion Criteria:  Have physical limitations (e.g., cardiorespiratory, orthopedic, central nervous system) that contraindicate participation in a low to moderate intensity home-based walking and progressive resistance program, according to the patient's physician (e.g., oncologist, primary care) or physician's designee Be identified as in the active or maintenance stage of exercise behavior per the Exercise Stages of Change Question on the Screening Form Have planned surgery or radiation treatment during the course of the study (hormonal and biologic therapy is allowed)