Inclusion Criteria:  Age: ≥ 18years old female patients. Patients who received radical radiotherapy and chemotherapy, and who needed supplementary radiotherapy due to the prognostic risk factors for treating pathologically diagnosed gynecological malignancies (including cervical cancer, endometrial cancer, and vulvar cancer), with no pathological type restrictions. The Eastern Cooperative Oncology GroupPerformance Status (ECOG PS) score: 0-1. Expected survival ≥12 months. The main organs functioned normally, which meant that they met the following criteria: Hemoglobin (Hb) ≥90g/L; Absolute neutrophil count (ANC)≥1.5×109/L; Platelet count (PLT) ≥50×109/L; Total bilirubin (TBIL)<1.5×upper limit of normal (ULN); Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST)<2.5×ULN,for patients with liver metastasis<5×ULN; Blood urea nitrogen (BUN) and Creatinine ratio (CR) ≤1×ULN or Endogenous creatinine clearance≥50ml/min(by Cockcroft-Gault equation). The subjects willingly participated inthe study, signed an informed consent form, were medication-compliant, and cooperated with the follow-ups.  Exclusion Criteria:  Patients with hypertension and could not control the blood pressure within the normal range after treating with antihypertensive medications (systolic blood pressure>140 mmHg and diastolic blood pressure>90 mmHg). Patients with a history of severe cardiovascular diseases, including myocardial ischemia or myocardial infarction above grade II, poorly controlled arrhythmia (QTc interval ≥470 ms in women), grade III~IV cardiac insufficiencyaccording to the New York Heart Association (NYHA) standards, orthe left ventricular ejection fraction (LVEF) < 50%shown by the heart color Doppler ultrasound. Patients with coagulation disorders (international normalized ratio (INR) >1.5, activated partial thromboplastin time (aPTT) >1.5 ULN), with bleeding tendency. Patients with a history of psychotropic medication abuse and unable to quit, and patients with mental disorders. Patients participatingin another drug trial. Patients with concomitant diseases that seriously endangered the safety of the patient or affected the completion of the study from the investigators' opinion. Not suitable for enrollment in the investigators' opinion.