Inclusion Criteria:  Female 18-40 years BMI 20-40 Reproductive age women with PCOS diagnosis  Irregular menstrual cycles  Chronic oligo/anovulation defined as an intermenstrual interval of >45 days < 8 menstrual cycles/year evidence of either hyperandrogenemia (elevation of total or free testosterone above the normal range for women) clinical hyerandrogenism (hirsutism and or acne) 3 years from menarche Agree to avoidance of pregnancy and to use barrier contraception for duration of study  Exclusion Criteria:  • Clinically ascertained presence of type I and type II Diabetes  Pregnancy and/or nursing  Medication exclusion  Use of medications and/or supplements that influence either ovarian function or insulin sensitivity, within 2 months: including oral contraceptive pills, hormonal implants, anti-androgens, antipsychotics or antihypertensives metformin, glucocorticoids, and/or health food remedies other than multi-vitamins and calcium; Subjects who are on oral contraception, metformin, or nutritional supplements must agree to discontinue these drugs and undergo an 8 week washout period before the tests are performed Other drugs that cannot be suspended during the FMD phase Alcohol usage more than 7 drinks/week