Inclusion Criteria:  ≥ 18 years old, weight > 30 Kg Eligible for Spine revision surgery, at least one year after primary surgery Agree to participate and sign the informed consent  The age and weight of patient are defined according to the instruction for use of the CADISS System currently on the EU market.  Exclusion Criteria:  < 18 years old Weight ≤ 30 kg Primary surgery Known hypersensibility to mesna Patient is pregnant, breastfeeding or has wish of pregnancy during the study. Unable to sign the informed consent Participation in any study involving an investigational drug or device within the past 3 Months. Individuals under tutorship or trusteeship.