Inclusion Criteria:  HCC (diagnosis: histological or radiological) Age: 18-80 Number of lesions 1-3 lesions Size of the lesion (or sum of 2-3 lesions) ≥ 4 cm Sufficient non-tumorous liver volume (≥ 800 cm3) Child Pugh Score: A5-6 or B7 BCLC A or B Patient is illegible or refused surgical resection or orthotopic liver transplant Blood work (within 2 weeks before registration): Absolute neutrophil count (ANC) ≥ 1,500 cells/mm³) Platelets ≥50,000 cells/mm³ AST (and ALT) < 5 times ULN Serum creatinine ≤ ULN or creatinine clearance ≥ 60 mL/min  Exclusion Criteria:  Evidence of extrahepatic disease (lymph node or distant metastases) Evidence of macroscopic vascular invasion Evidence of an arterio-portal or arterio-venous fistulas History of previous malignancy Active hepatitis B Previous SIRT Previous Sorafenib in the last 8 weeks Pregnant and lactating females