Inclusion Criteria:  Healthy volunteers: ages 18 - 55 years old; Primary residence elevation of 2,461 ft (750m) or lower; Not ascending to altitude >10,000 ft within 4 months prior to screening; Females of childbearing potential must have a negative pregnancy test and established on a method of contraception that in the investigator's opinion is acceptable. Females must agree to remain on their established method of contraception from the time of the screening visit and throughout the study period; Willing to participate voluntarily and sign a written informed consent.  Exclusion Criteria:  Subjects with medical history of cardiovascular, cerebrovascular diseases or asthma; uncontrolled hypertension with SBP>140 and or DBP>90 mmHg; Subjects with current and clinically significant respiratory system disease, digestive disease, liver disease, central nervous system disease, psychiatric disease, metabolic disease, renal disease, acute infection or anemia, or who test positive for COVID-19 (COVID testing will be performed, not per study requirement, but in compliance with local law or policy, and subject with known positive for COVID-19 will be excluded). Total LLSS score (LLSS score) is ≥2 at any check point during screening period; Blood oxygen saturation (SpO2), preferably tested on the left-hand index finger, is less than 95% at screening visits; Subjects with abnormal renal or liver function with clinical significance (ALT or AST > 2×ULN, Creatinine > ULN) at screening visit; Subjects with CRP > ULN at screening visit; Subjects with primary (migraine, tension-type headache, and cluster headache etc.) or secondary headaches (headache related to infection, vascular disease etc.) within one month at screening; Surgery or blood donation within 3 months prior to screening; On treatment of any medications (including any dietary supplements) except for birth control within 14 days prior to screening and throughout the study period; Smokers who had a habit of smoking during the last 4 months prior to the starting of screening; Contradictive to treatment of Danshen (Radix Saliva Miltiorrhize Bge., RSM) products; Women who are pregnant or lactating. Substance abuse. Subjects with a recent (within the last 6 months) history of substance abuse (alcohol, marijuana, or known drug dependence). Or subjects who have a positive urine substance test at screening; Participation in any other interventional clinical trial or on an investigational drug within 30 days prior to screening; A family member or relative of the study site staff; Any condition that, in the opinion of the investigator, is likely to prevent compliance with the study protocol, interfere with the assessment, or pose a safety concern if the subject participates in the study at screening.