Inclusion Criteria:  Healthy, adult, male or non-pregnant, non-lactating females Given written informed consent No clinically significant health problems Agree to avoid conception through Day 29 Agree to minimize blood and body fluid exposures to others after vaccination through Day 29 Agree to avoid exposure to immunocompromised persons after vaccination through Day 29 Agree to avoid employment in industry involved with livestock after vaccination through Day 29  Exclusion Criteria:  Signs or symptoms of acute COVID-19 within 1 week before vaccination. Prior infection with Nipah virus Prior infection with vesicular stomatitis virus (VSV) Received VSV-vectored vaccine BMI > 35 Healthcare worker with direct physical contact with patients Childcare worker in direct contact with children 5 years old or younger Household contact who is immunodeficient, or on immunosuppressive medication Hands-on food preparation job Primary care or treatment of cattle, horses, llamas or swine Hepatitis B, hepatitis C, HIV-1, HIV-2, diabetes, atopic dermatitis (eczema), chronic inflammatory disease, autoimmune or autoinflammatory disorder, malignancy, chronic or active neurologic disorder, ; History of severe reactions to any vaccine or history of severe allergies Receipt of another investigational vaccine within 30 days or a licensed vaccine within 14 days (live vaccine within 30 days) Known allergy to components of PHV02 Injection sites obscured by tattoos or physical condition Significant psychiatric or medical condition or laboratory abnormality on screening History of Guillain Barre Syndrome or any chronic or acute neurological disorder Alcohol or illicit drug abuse within past 5 years Pregnant or lactating female Administration of blood or IgG within 120 days preceding study History of blood donation within 60 days of study Unwilling to undergo diagnostic evaluation of rash (skin biopsy, if indicated) or joint symptoms (athrocentesis if indicated by joint effusion), in both cases if acceptable to subject History of chronic autoimmune/autoinflammatory disease Elective surgery planned during the study period Subjects who have not adhered to and do not agree to adhere to local and institutional guidelines for COVID-19 prevention or testing