Key Inclusion Criteria:  Is healthy, or has chronic medical condition(s) that per the opinion of the investigator is (are) stable, well-controlled, and not likely to require medical intervention through the end of study Does not require medication(s) for co-morbid condition, or has received stable medication(s) for co-morbid condition(s) for at least 6 months prior to screening Weighs between ≥60 kg and ≤100 kg at the time of screening Has SARS-CoV-2-negative reverse-transcriptase polymerase chain reaction (RT-PCR) from a sample collected ≤72 hours prior to randomization, using local assay and sample collection and assay standards Has completed a full course of COVID-19 vaccination more than 6 weeks prior to randomization  Key Exclusion Criteria:  Has active respiratory or non-respiratory symptoms consistent with COVID-19 in the opinion of the Investigator Has recent SARS-CoV-2 infection that resolved within 6 weeks prior to randomization Prior use of casirivimab+imdevimab at any time prior to randomization Prior, current, or planned use during the study of any of the following treatments: COVID-19 convalescent plasma, other monoclonal antibodies against SARS-CoV-2 (eg, bamlanivimab and etesevimab, sotrovimab), intravenous immunoglobulin (any indication), or any other investigational, authorized, or approved agent intended for COVID-19 treatment or prevention (with the exception of COVID-19 vaccines) Treatment with another investigational drug in the last 30 days or within 5 half-lives of the investigational drug, whichever is longer, prior to screening Body mass index (BMI) ≥28 kg/m2 Medically-attended acute illness, systemic antibiotics use, or hospitalization for any reason within 30 days prior to screening Acute exacerbation of a chronic pulmonary condition (eg, chronic obstructive pulmonary disease [COPD], asthma exacerbations) in the past 6 months prior to screening Uncontrolled hypertension, in the opinion of the investigator History of heart failure hospitalization, diagnosis of a myocardial infarction, stroke, transient ischemic attack, unstable angina, percutaneous or surgical revascularization procedure (coronary, carotid, or peripheral vascular), or intracardiac device placement (eg, pacemaker) within 12 months prior to screening Cancer requiring treatment currently or in the past 5 years, except for non-melanoma skin cancer or cervical/anus in-situ Is pregnant at screening  Note: Other protocol-defined Inclusion/ Exclusion Criteria apply