Inclusion Criteria:  Hospitalized patients aged ≥18 years. Confirmed diagnosis of COVID-19 by RT-PCR or antigen test in respiratory samples. Time between symptom onset and inclusion ≤ 7 days. Enrolled within 5 days of hospitalization. Sign the consent form.  Exclusion Criteria:  Contraindication to transfusion due to inability to tolerate additional fluid, such as due to decompensated congestive heart failure. History of previous severe allergic reactions to transfused blood products. Limiting comorbidity for administering the therapies provided for in this protocol in the opinion of the investigator. Not currently enrolled another interventional clinical trial of COVID-19 treatment. Critically ill patient with COVID-19 being treated in intensive care.