Inclusion Criteria:  Tumor types: melanoma, NSCLC, RCC, UC, HNSCC, TNBC, gastric/GEJ cancer, cervical, anal, or MSI-high tumors. Additionally up to 10 subjects with other locally advanced or metastatic solid tumor types not listed above.  Signed Informed Consent Form  Age ≥18 years at time of signing the Informed Consent Form  Life expectancy ≥ 6 months  Ability to comply with the trial protocol  Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1  Adequate hematologic and end-organ function, defined by the following laboratory test results, obtained within 14 days prior to initiation of trial treatment:  ANC ≥1.5 × 109/L (1500/µL) without granulocyte colony-stimulating factor support  Lymphocyte count ≥0.5 × 109/L (500/µL)  Platelet count ≥100 × 109/L (100,000/µL) without transfusion  Hemoglobin ≥90 g/L (9 g/dL)  Subjects may be transfused to meet this criterion.  AST and ALT ≤3 × ULN  Alkaline phosphatase (ALP) ≤2.5 × ULN, with the following exceptions:  Subjects with documented liver or bone metastases: ALP ≤5 × ULN  Total bilirubin ≤1.5 × ULN with the following exception:  Subjects with known Gilbert disease: total bilirubin ≤3 × ULN  Measured or calculated creatinine clearance ≥50 mL/min (according to the Cockcroft-Gault formula)  Albumin ≥25 g/L (2.5 g/dL)  For subjects not receiving therapeutic anticoagulation: International Normalized Ratio (INR) and activated partial thromboplastin time (aPTT) ≤1.5 × ULN  For subjects receiving therapeutic anticoagulation: stable anticoagulant regimen  Female subjects of childbearing potential must have a negative serum pregnancy test result within 14 days prior to initiation of trial treatment.  Female subjects of childbearing potential must agree to use a highly effective form of contraception during treatment and for at least 90 days after the final dose of VB10.NEO, and for 5 months after the final dose of atezolizumab, whichever occurs later. Highly effective forms of contraception include:  combined (estrogen and progestogen containing) hormonal contraception associated with inhibition of ovulation: oral, intravaginal, transdermal  progestogen-only hormonal contraception associated with inhibition of ovulation: oral, injectable, implantable  intrauterine device  intrauterine hormone-releasing system  bilateral tubal occlusion  vasectomized partner  sexual abstinence (defined as refraining from heterosexual intercourse during the entire period of risk associated with the trial treatments. The reliability of sexual abstinence needs to be evaluated in relation to the duration of the clinical trial and the preferred and usual lifestyle of the subject. Periodic abstinence [calendar, symptothermal, post-ovulation methods], withdrawal [coitus interruptus], spermicides only, and the lactational amenorrhea method are not acceptable methods of contraception).  For men with a female partner of childbearing potential or pregnant female partner: agreement to remain abstinent (refrain from heterosexual intercourse) or use a condom during the treatment period and for at least 28 days after the final dose of trial treatment to avoid exposing the embryo, and agreement to refrain from donating sperm. Histologic documentation of locally advanced, recurrent, or metastatic incurable malignancy that has progressed after at least 1 available standard therapy; or for whom standard therapy has proven to be ineffective or intolerable or is considered inappropriate; or for whom a clinical trial of an investigational agent is a recognized SOC.  Exclusion Criteria:  Pregnant or breastfeeding, or intending to become pregnant during the trial or within 90 days after the last dose of VB10.NEO or 5 months after the last dose of atezolizumab, whichever occurs later  Significant cardiovascular disease such as, but not limited to, New York Heart Association Class III or IV cardiac disease, myocardial infarction within the last 6 months, unstable arrhythmias, or unstable angina  QT interval corrected through use of Fridericia's formula (QTcF) >470ms demonstrated by at least 2 electrocardiograms (ECGs) >30 minutes apart  Clinically significant liver disease including active viral, alcoholic, or other hepatitis, cirrhosis, and inherited liver disease or current alcohol abuse  Positive hepatitis B surface antigen (HBsAg) test at screening  Subjects with past or resolved hepatitis B infection (defined as having a negative HBsAg test and a positive IgG antibody to hepatitis B core antigen) are eligible.  Positive hepatitis C virus (HCV) antibody test at screening  Subjects positive for HCV antibody are eligible only if polymerase chain reaction is negative for HCV ribonucleic acid (RNA)  Positive human immunodeficiency virus (HIV)-1 test at screening  Active tuberculosis  Any other diseases, metabolic dysfunction, physical examination finding, and/or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug or that may affect the interpretation of the results or may render the subject at high risk from treatment complications  Known primary immunodeficiencies  Active, or history of, autoimmune disease or immune deficiency, including, but not limited to, myasthenia gravis, myositis, autoimmune hepatitis, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, antiphospholipid antibody syndrome, Wegener granulomatosis, Sjögren syndrome, Guillain-Barré syndrome, or multiple sclerosis, with the following exceptions:  Subjects with a history of autoimmune-related hypothyroidism who are on thyroid replacement hormone are eligible for the trial.  Subjects with controlled Type 1 diabetes mellitus who are on an insulin regimen are eligible for the trial.  Subjects with eczema, psoriasis, lichen simplex chronicus, or vitiligo with dermatologic manifestations only (e.g., subjects with psoriatic arthritis are excluded) are eligible for the trial provided all of the following conditions are met:  Rash must cover <10% of body surface area  Disease is well controlled at baseline and requires only lowpotency topical corticosteroids  No occurrence of acute exacerbations of the underlying condition requiring psoralen plus ultraviolet A radiation, methotrexate, retinoids, biologic agents, oral calcineurin inhibitors, or high potency or oral corticosteroids within the previous 12 months  History of severe allergic anaphylactic reactions to chimeric or humanized antibodies or fusion proteins.  Known hypersensitivity to Chinese hamster ovary cell products or to any component of the atezolizumab formulation.  Known allergy or hypersensitivity to any component of the VB10.NEO formulation.  History of idiopathic pulmonary fibrosis, pneumonitis (including drug-induced), organizing pneumonia (i.e., bronchiolitis obliterans, cryptogenic organizing pneumonia, etc.), or evidence of active pneumonitis on imaging conducted for tumor assessment at screening  History of radiation pneumonitis in the radiation field (fibrosis) is permitted  History of drug-induced pneumonitis that was asymptomatic (defined by radiographic findings only) and reversible (without any anti-inflammatory therapies) is permitted.  Severe infection within 28 days prior to Cycle 1, Day 1, including, but not limited to, hospitalization for complications of infection, bacteremia, or severe pneumonia  Subjects receiving prophylactic antibiotics (e.g., to prevent a urinary tract infection or chronic obstructive pulmonary disease [COPD] exacerbation) are eligible for the trial.  Uncontrolled pleural effusion, pericardial effusion, or ascites requiring recurrent drainage procedures (once monthly or more frequently)  Subjects with indwelling catheters (e.g., PleurX) are allowed.  Uncontrolled or symptomatic hypercalcemia (ionized calcium >1.5 mmol/L, calcium >12 mg/dL, or corrected calcium >ULN)  Major surgical procedure within 28 days prior to Cycle 1, Day 1, or anticipation of need for a major surgical procedure during the course of the trial  Prior allogeneic stem cell or solid organ transplantation  Treatment with systemic immunostimulatory agents (including, but not limited to, interferon and IL-2) within 28 days or 5 drug-elimination half-lives (whichever is longer) prior to Cycle 1, Day 1  Treatment with systemic immunosuppressive medications (including, but not limited to, prednisone >7.5 mg/day, cyclophosphamide, azathioprine, methotrexate, thalidomide, and tumor necrosis factor-alpha [TNF-α] antagonists) within 2 weeks prior to Cycle 1, Day 1 with the following exceptions:  Subjects who received acute, low-dose systemic immunosuppressant medication or a one-time pulse dose of systemic immunosuppressant medication (e.g., 48 hours of corticosteroids for a contrast allergy) are eligible for the trial after medical monitor confirmation has been obtained  Subjects who received mineralocorticoids (e.g., fludrocortisone), corticosteroids for COPD or asthma, or low-dose corticosteroids for orthostatic hypotension or adrenal insufficiency are eligible for the trial.  Treatment with investigational therapy within 28 days prior to Cycle 1, Day 1  Live, attenuated vaccines are prohibited within 28 days prior to Cycle 1, Day 1, during atezolizumab treatment, and for 5 months after the final dose of atezolizumab  Vaccination with an approved COVID-19 vaccine that does not contain live, attenuated virus is permitted