Inclusion Criteria:  Age>18 years Confirmed diagnosis of AL-AMY and symptomatic organ involvement. Initiated first line treatment for AL-AMY in the period 2004-2018. Patients who have signed a participation agreement/ICF allowing data collection and source data verification in accordance with local requirements.  The inclusion of deceased subjects in the study is permitted under the condition that consent waiver has been granted by the Scientific Committee and/or Administrative Board of the participating sites and/or any applicable regulatory body, as per local regulations, to either implement a hospital informed consent form (ICF) already in place or provide written approval of this study-specific waiver. In the occasion that waiver of consent is not granted deceased subjects will not be enrolled in the study.  Exclusion Criteria:  Patients under the age of 18 will not be considered eligible for this study