Inclusion Criteria:  Has mild to moderate KOA (defined as Kellgren-Lawrence [KL] grade 2 to 3) on affected limb Has quadriceps weakness (<7.5N/kg/m2) Can ambulate >50 feet unassisted Must have negative laboratory test results for human immunodeficiency virus, hepatitis B surface antigen (HBsAg), and hepatitis C virus (HCV) at the Screening Visit Has a body mass index (BMI) of <40kg/m2 A male must agree to use contraception during the treatment period and for at least 3 months after the last dose of study treatment and refrain from donating sperm during this period.  A female is eligible to participate if she is not pregnant, not breastfeeding, and at least one of the following conditions applies:  Not a woman of childbearing potential (WOCBP). OR A WOCBP who agrees to follow the protocol's contraceptive guidance during the treatment period and for at least 3 months after the last dose of study treatment. Female has a negative pregnancy test result at screening and prior to investigational medicinal product (IMP) administration Capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in the protocol Willing and able to comply with all study requirements, according to the judgment of the Investigator Has discontinued systemic oral or intravenous steroid use for 6 months prior to Screening Has vital sign measurements within the following ranges at Baseline (predose at Visit 2): heart rate >50 and <100 bpm, systolic blood pressure >100 and <170 mmHg, diastolic blood pressure >50 and <90 mmHg, and blood oxygenation (by pulse-oximetry) >95% Participant has undergone and failed at least 1 3-month or longer treatment regimen (ie, activity modification, weight loss, physical therapy, anti-inflammatory medications, or injection therapy) within a 2-year period prior to the Screening visit.  Exclusion Criteria:  Moderate to severe KOA (defined as KL grade >3) on contralateral limb Has had prior total knee arthroplasty Has a known hypersensitivity to any components of the study medication or comparative drugs (and/or an investigational device) as stated in this protocol Has current or past history of malignancy (10y) excluding nonmelanoma skin cancer Has neurological, vascular, or cardiac condition that limit function, or, in the opinion of the investigator, could jeopardize or would compromise the study participant's ability to participate in this study Has uncontrolled comorbidities including diabetes, hypertension, cardiovascular disease, asthma, or COPD. Is taking a prohibited medication or has taken a prohibited medication (narcotic pain medication, local anti-inflammatory, other investigational drugs) Participant has had a change in medication to manage comorbid condition(s) (including diabestes, hypertension, asthma, and cardiovascular disease) within 1 month of the Screening visit. Participant received intra-articular cortisone or viscosupplementation product(eg, Synvisc®) injections within 3 months prior to the first dose of IMP. Has had administration of a live, attenuated vaccine within 28 days of starting study treatment or anticipation that such vaccine will be required during the study Prior/concurrent clinical study experience Has current or chronic history of liver disease or known hepatic or biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones) Has a positive urine drug screen (with the exception of benzodiazepine) prior to dosing on Day 1. If a study participant presents with a positive drug screen, the participant may be rescheduled at the discretion of an Investigator. Has the presence of hepatitis B surface antigen (HBsAg) or hepatitis C antibody (HCVAb) test result at Screening or within 3 months prior to starting study medication Tests positive for human immunodeficiency virus-1/2 antibody (human immunovirus 1/2Ab) at Screening or within 3 months prior to the first dose of study medication Has current or past history (10y) of smoking Has a history of chronic alcohol or drug abuse within the previous 3 months Participant is currently using a systemic oral or intravenous steroid regimen (eg, for asthma or other chronic respiratory condition) or brief course of systemic pulse steroid administration (eg, for flare up of nonarthritic condition or COVID-19).