Inclusion Criteria:  Primary tumor resected according to standard oncological practice, p≤T4a, R0 resection Colorectal liver metastasis considered as non-resectable either up-front or after previous hepatic resections No local recurrence of primary colon cancer confirmed by Positron Emission Tomography, Computed Tomography and colonoscopy No extra-hepatic metastatic disease confirmed by Positron Emission Tomography and Computed Tomography Good performance status Eastern Cooperative Oncology Group 0 or 1 Neutrophils > 1.000 Patients who received at least one line of chemotherapy for at least 3 months with partial response or stable disease according to modified Response Evaluation Criteria in Solid Tumours Carcino-Embryonic Antigen < 80 µg/L or reduction of ≥ 50% of highest Carcino-Embryonic Antigen level observed Written informed consent No other contraindications to liver transplantation  Exclusion Criteria:  Presence of other malignancies Local recurrence of primary tumor Extra-hepatic metastatic disease Patients who did not receive any neoadjuvant or adjuvant therapy Palliative resection of primary tumor Any other reason, according to the investigators, that could be a contraindication to protocol enrollment