Inclusion Criteria:  Adult aged ≥ 18 years old Patients diagnosed with HFpEF;  Diagnostic criteria including:  LVEF 50% or higher; BNP≥35 pg/mL and/or NTproBNP≥125 pg/mL; Presence of symptoms and/or signs of heart failure; At least one additional criteria: relevant structure heart disease or diastolic dysfunction  Exclusion Criteria:  Severe liver failure; Other causes of shortness of breath, such as severe pulmonary disease or severe ● chronic obstructive pulmonary disease; Primary pulmonary hypertension. Severe left valvular heart disease. Long-term bedridden or unable to move autonomously Age < 18