Inclusion Criteria:  Subject with moderate to severe nasolabial folds as determined by a Wrinkle Severity Rating Scale (WSRS) score of 3 or 4 on both folds at the pre-treatment evaluation. Subject wiling to abstain from other facial procedures (i.e., dermal fillers, toxin treatments, laser, microdermal abrasion, chemical peels, non-invasive skin-tightening) during the whole study period. Subject, psychologically able to understand the study related information and to give a written informed consent. Subject having given freely and expressly his/her informed consent. Subject willing to have photographs of the face taken. Subject affiliated to a health social security system. Female of childbearing potential should use a contraceptive regimen recognized as effective since at least 12 weeks before screening visit and during the whole study period.  Exclusion Criteria:  Pregnant or nursing woman or planning a pregnancy during the study. Subject with a scar, moles, pigment disorders or anything on the face which might interfere with the evaluation. Subject who had been deprived of their freedom by administrative or legal decision or who is under guardianship. Subject in a social or sanitary establishment Subject participation to another research on human beings or who is in an exclusion period of one. Subject having received 4500 euros indemnities for participation in research involving human beings in the 12 previous months, including participation in the present study. Subject suspected to be non-compliant according to the investigator's judgment. Subject suffering from a severe or progressive disease or any other pathology that may interfere with the evaluation of the study results. Subject with known history of or suffering from autoimmune disease and/or immune deficiency. Subject suffering from inflammatory and/or infectious cutaneous disorders in or near the studied zones (e.g. acne, mycosis, papilloma, chronic eczema, atopic dermatitis…). Subject with labial herpes in the last 2 years is not eligible even if asymptomatic at time of screening visit. Subject with an abscess, unhealed wound, or a cancerous or precancerous lesion on the studied zone. Subject prone to develop inflammatory skin conditions or having tendency to bleeding disorders. Subject with a tendency to develop keloids or hypertrophic scarring. Subject having history of allergy or anaphylactic shock including hypersensitivity to Poly-l-lactic acid, to lidocaine or to one of the components of the tested devices or antiseptic solution. Subject having received treatment with a laser, a dermabrasion, a surgery, a deep chemical peeling or other ablative procedure on the face within the past 12 months prior to screening visit. Subject having received injection with a resorbable filling product in the face area within the past 12 months prior to screening visit. Subject having received at any time injection with a slowly resorbable filling product (polylactic acid, calcium hydroxyapatite, combinations of hyaluronic acid (HA) and hypromellose, HA and dextran microbeads or HA and TriCalcium Phosphate (TCP), …) or with a non-resorbable filling product (polyacrylamide, silicone, combination of methacrylic polymers and collagen, polymer particles, …) on the face. Subject having received at any time a treatment with tensor threads on the face. Subject having started or changed her oral contraceptive or any other hormonal treatment during 12 weeks prior to screening visit. Subject using medication such as aspirin, nonsteroidal anti-inflammatory drugs (NSAID) (ibuprofen, naproxen, …), antiplatelet agents, anticoagulants or other substances known to prolong bleeding time within 1 week prior to injection visits.  Subject undergoing a topical treatment on the test area or a systemic treatment:  Antihistamines during the 2 weeks prior to screening visit. Immunosuppressors and/or corticoids during the 4 weeks prior to screening visit. Retinoids during the 6 months prior to screening visit. Intensive exposure to sunlight or UV-rays within the previous month before and after injection visits.