Inclusion Criteria:  Body mass index 18.0 to 30.0 kg/m^2, inclusive Willing and able to participate in the whole study Have regular bowel movements (i.e., average stool production of ≥1 and ≤3 stools per day) Provide written informed consent Adhere to the contraception requirements.  Exclusion Criteria:  Have received any investigational medicine in a clinical research study within 90 days Are, or are immediate family members of, a study site or sponsor employee Evidence of current severe acute respiratory syndrome (SARS-CoV-2) infection History of any drug or alcohol abuse, or regularly consume >21 units alcohol per week Current smoker or user of e-cigarettes and nicotine replacement products within the last 6 months Have pregnant or lactating partners Radiation exposure, exceeding 5 milliSieverts (mSv) in the last 12 months or 10 mSv in the last 5 years Clinically significant abnormal results of clinical chemistry, hematology or urinalysis as judged by the investigator Confirmed positive drugs of abuse test result Positive hepatitis B surface antigen (HBsAg), hepatitis C virus antibody (HCV Ab) or human immunodeficiency virus (HIV) antibody results Active renal and/or hepatic disease History of clinically significant cardiovascular, renal, hepatic, dermatological, chronic respiratory or gastrointestinal (GI) disease, neurological or psychiatric disorder Any form of cancer within the last 5 years (exceptions apply) History and/or symptoms of adrenal insufficiency Condition that could be aggravated by glucocorticoid antagonism or activation Donation of blood or plasma or loss of greater than 400 mL of blood within the previous 3 months Are taking, or have taken, any prescribed or over-the-counter drug or herbal remedies (other than up to 4 g of paracetamol per day) within 14 days. COVID-19 vaccines are accepted concomitant medications. Exceptions may apply on a case by case basis. Currently using glucocorticoids or have a history of systemic glucocorticoid use at any dose within the last 12 months or 3 months for inhaled products Additional criteria apply.