Inclusion Criteria:  Cases:  Patients must be 18 years of age or older with a confirmed or suspected diagnosis of sinonasal cancer Patients must have either a routine diagnostic biopsy of primary tumor or surgical resection planned as part of routine care (to allow for the collection of tumor sample for the study) or grant access to archival material, from a previously performed biopsy. Willing to provide 20 mL blood sample Ability to understand and the willingness to sign a written informed consent document  Controls:  Must be 18 years of age or older within the categories of age, gender, and race needed to match cases Ability to understand and the willingness to sign a written informed consent document  Exclusion Criteria:  Cases:  Presence of medical or psychiatric condition affecting ability to give voluntary, informed consent Participants who do not speak English and do not agree to use of a telephone or video interpreter will be excluded. However, if there is a hearing, literally or minor fluency issue and the participant requests assistance from a family member or the study coordinator, this individual may still enroll and receive this assistance to ensure they fully hear and understand everything being asked  Controls:  Presence of medical or psychiatric condition affecting ability to give voluntary, informed consent Participants who do not speak English and do not agree to use of a telephone or video interpreter will be excluded. However, if there is a hearing, literacy or minor fluency issue and the participant requests assistance from a family member or the study coordinator, this individual may still enroll and receive this assistance to ensure they fully hear and understand everything being asked No prior diagnosis of head and neck cancer, except basal cell cancer No previous radiation therapy of the head and neck