Inclusion Criteria:  Subject is at least 18 years old Subject has a degenerative aortic stenosis with mean valvular gradient ≥40 mmHg Subject has a formal heart-team indication for TAVR Subject has one or more stable coronary stenosis lesions 30-90% by visual estimation, in a vessel over 2 mm in diameter, and which is amenable for pressure-wire analysis Subject agrees to participate in the study and is able to sign the informed consent form  Exclusion Criteria:  Subject is unable to provide informed consent Subject has asthma or acute bronchospasm Subject has unstable angina or myocardial infarction Subject meets any contraindication in the applicable OptoWire IFU Subject is pregnant