Inclusion Criteria (oral cancer patients):  Biopsy-proven squamous cell carcinoma (SCC) of the oral cavity that requires surgical resection Lesion is at least 1 cm in greatest surface dimension  Exclusion Criteria (oral cancer patients):  History of prior surgical, chemotherapeutic, or radiation treatment for head and neck cancer Pregnancy or lactation  Inclusion Criteria (healthy subjects):  In good general health as evidenced by medical history  Exclusion Criteria (healthy subjects):  Clinically and/or histologically proven oral pre-cancer, oral cancer Pregnancy or lactation