Inclusion Criteria:  Patients who meet all the following criteria will be eligible for inclusion in this study:  Willing and able to provide written informed consent (ages greater or equal to 18 years) or parental/guardian consent and patient assent (age <18 years), as required by the IRB or institution or IRB, per local regulations Male or female patients with documented diagnosis of SCD (all genotypes) Have been treated with Oxbryta for at least 2 weeks, according to the Oxbryta USPI  Exclusion Criteria:  -