Inclusion Criteria:  Females of age group (15-40yrs) diagnosed with PCOS. The diagnosis of PCOS will be according to Rotterdam criteria, when any two out of the following three abnormalities will be present:  clinical (hirsutism, acne or acanthosis nigricans) and/or biochemical (raised testosterone) hyperandrogenism ; chronic anovulation (oligomenorrhoea or amenorrhea); and polycystic ovaries on ultrasound (one or both ovaries demonstrate 12 or more follicles measuring 2 to 9 mm in diameter or the ovarian volume exceeds 10 cubic cm on pelvic ultrasound) from department of Obstetrics and Gynaecology, Post Graduate Institute of Medical Sciences, Rohtak. presence of ≥20 natural teeth BMI (18.5 - 24.9)  Systemically healthy females {Age and BMI matched with PCOS women} diagnosed on the basis of  Regular mensturation, No clinical or biochemical sign of hyperandrogenism and Ultrasound exclusion of PCOS  Exclusion Criteria:  Previous history of androgen-secreting tumors, congenital adrenal hyperplasia , hyperprolactinemia, or any thyroid dysfunction Patients with chronic inflammatory disease such as nephrotic syndrome, chronic renal failure, significant cardiovascular disease, established type 1 or type 2 diabetes mellitus, or active cancer within the past 5 years Smokers and alcoholics, History of systemic antibiotics or oral contraceptives usage within last 3 months, Periapical pathology or other oral inflammatory conditions and any periodontal treatment within 6 months prior to study