Inclusion Criteria:  Patients with well-fixed prosthesis; Patients who have preoperative diagnosis of TKA-PJI ongoing no more than 4 weeks prior to study drug administration  Exclusion Criteria:  Patients for whom a DAIR procedure is not indicated; Patients with loose prosthesis and/or surgical treatment requiring removal of well-fixed, non-modular implants at screening; Presence of a sinus tract(s) at screening; Patients on chronic antibiotic therapy within 3 months of diagnosis of the PJI at screening; Patients with previous history or presence of osteomyelitis in the index limb; Patients who have uncontrolled diabetes mellitus; Patients who have anemia at screening; Patients with body mass index >40 kg/m2 at screening; Patients who are immunosuppressed; Patients who require therapeutic anticoagulation and/or antiplatelet therapy