Inclusion Criteria:  Have histologically or cytologically confirmed metastatic or locally advanced NSCLC, and have not received prior systemic therapy. Subjects with locally advanced disease must have Stage III NSCLC and are not candidates for surgical resection or definitive chemoradiation Tumor PD-L1 expression (TPS≥1%) as determined by PD-L1 22C3 immunohistochemistry local or central assay. Have measurable disease Agree to provide screening biopsy (or archival tissue) at screening to assess PD-L1 ECOG 0-1 Adequate hematologic and end organ function  Exclusion Criteria:  Prior systemic anti-cancer therapy NSCLC with EGFR, or ALK, or BRAF or ROS or RED or other genomic tumor aberrations which have available therapy Prior radiotherapy within 2 weeks of start of study treatment Known active CNS metastasis or carcinomatous meningitis Severe reactions to mAbs or IV immunoglobulin preparations Autoimmune disease history in past two years