Inclusion Criteria (summary):  Ability and willingness to provide informed assent or written consent or consent from their legal representative. Fluency in the language of the study staff Age 5 to 18 years A documented history of TSC, Refractory seizure treatment status Currently receiving one or more anti-epileptic drugs (AEDs) Stable medications or interventions for epilepsy Willingness to complete Patient Reported Outcome  For female patients of childbearing potential:  Willingness to undergo serum or urinary pregnancy testing at screening and during the trial period. Willingness to use contraception.  Exclusion Criteria (summary):  Neurologic disease other than TSC. Recent anoxic episode Patient weight below 15kg Clinically significant unstable medical condition(s). Pregnancy or lactation.