Inclusion Criteria:  Age group 18-65; Newly diagnosed smear or GeneXpert positive for TB with or without SARS-CoV-2 (present or prior asymptomatic) disease; Willing to provide written informed consent.  Exclusion Criteria:  Any prior episode of TB disease; Treatment for current TB episode >1 week before enrollment; Drug resistance TB patients; Pregnancy or childbirth within last 6 months; Diabetes, HIV-seropositive and current use of immunosuppressive and steroid therapy Mild, Moderate and severe Covid-19 disease.