Inclusion Criteria:  Clinical diagnosis of real pancreatic swelling or submuscular swelling; Patients need to be guided by ultrasound endoscopy under the guidance of puncture to eliminate malignant lesions or clear lesions; Fully communicate before surgery, understand the risks and benefits of endoscopic operation, and sign an informed consent form.  Exclusion Criteria:  There are endoscopic operation contraindications, including abnormal blood clotting, or long-term oral anticoagulant antiplatelet drugs, can not guarantee INR < 1.5, or platelets less than 5 x 10 x 9 / L; Pregnant woman