Inclusion Criteria:  Mandarin-speaking subjects. Not clinically demented. Meeting the cutoff values of MMSE and CDR. With positive variation of rs3777215, rs234434, rs71352238, and rs4420638.  Exclusion Criteria:  Had major neurologic diagnosis (e.g., Parkinson's disease, stroke, encephalitis, and epilepsy) or other condition that might impair cognition or confound assessments. Had a history of psychotic episodes or had major depression (Hamilton Depression Rating Scale score > 24 points). Had severe systemic diseases, such as tumors, cardiovascular or orthopedic disorder that can affect the ability to perform the proposed intervention tasks.