Inclusion Criteria:  Patients will be adult (> age of 18) patients. Both men and women and members of all races and ethnic groups will be included Histologically confirmed malignancy for which standard curative measures in conjunction with radiotherapy are indicated to the following sites: whole breast/chest-wall for post-surgical radiotherapy or bilateral neck (levels one through six) for head and neck cancer All head and neck cancer patients should have the left and right neck treated to the same dose when receiving bilateral neck irradiation Ability to understand and the willingness to sign a written informed consent document  Exclusion Criteria:  Clinically evident skin involvement of malignancy Thin patients with nodal involvement requiring bolus Patients with significant unshaven facialor chest wall hair compromising film application Evidence of active cellulitis or wound infection involving anticipated treatment site History of prior radiotherapy to involved site within 5 cm of anticipated treatment field Eastern Cooperative Oncology Group (ECOG) performance status >= 3 Patients receiving concurrent capecitabine Patient with skin grafts over treatment site(s) Presence of psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule. (i.e. schizophrenia, autism, temporary housing during treatment, scheduling conflict immediately after treatment. This will need to be assessed prior to consent Actual or perceived inability to reliably apply StrataXRT to the patients treatment field in the home environment Anticipated or actual use of other non-study topical medications or remedies in the treatment field Vulnerable populations (pregnant women, decisionally impaired adults, and prisoners) will be excluded from the study Patients receiving ultra-hypofractionated radiation to the breast