Inclusion Criteria:  Patients must meet ALL of the following criteria:  GENERAL INCLUSION CRITERIA: Candidates for this study must meet ALL of the following criteria prior to randomization:  Pre-PCI:  The patient must be ≥18 years of age. Symptoms of acute myocardial infarction (AMI) with ECG and/or biomarker evidence of ST-segment elevation myocardial infarction (STEMI).  Cardiogenic shock is defined by the presence of at least 2 of the below criteria:  Hypotension due to a primary cardiac cause (systolic blood pressure [SBP] <90 mmHg refractory to urgent medical care and/or not responsive to initial medical care or requiring inotropes or vasopressors or mechanical circulatory support to maintain SBP >90 mmHg) Signs of end organ hypoperfusion (cool extremities, oliguria or anuria, or elevated lactate levels) Hemodynamic criteria represented by cardiac index <2.2 L/min/m2 or cardiac power output (CPO) <0.6 W. Patient had pulmonary artery catheters placed for hemodynamic monitoring for clinical reasons Patient is treated with mechanical circulatory support with an Impella CP. Patient or legally authorized representative has been informed of the nature of the study, agrees to its provisions and has been provided and signed written or remote/electronic informed consent, approved by the appropriate Institutional Review Board (IRB).  Patient or legally authorized representative and his/her physician agree to all required follow-up procedures and visits.  ANGIOGRAPHIC INCLUSION CRITERIA: These are evaluated after the patient has undergone cardiac catheterization and PCI and has provided signed Informed Consent:  Based on coronary anatomy, PCI is indicated for revascularization of the culprit lesion(s) with use of a commercially available coronary stent (bare metal or drug-eluting, at operator discretion). Successful angioplasty with stenting is completed <6 hrs from AMI symptom onset, as documented by less than 30% diameter residual angiographic stenosis within all treated culprit lesions with TIMI 2 or 3 flow and no major complications such as perforation. For coronary intervention, intravenous antiplatelet agents were used Expected ability to place the SSO2 delivery catheter in the coronary ostium to deliver SSO2 Therapy with stable, coaxial alignment. Systemic arterial pO2 greater than or equal to 80 mmHg as measured by arterial blood gas (may be repeated if low after supplemental O2 administration).  Exclusion Criteria:  Patients will be excluded if ANY of the following conditions apply:  GENERAL EXCLUSION CRITERIA  Pre-PCI:  A surgical procedure is planned during the first 30 days post-enrollment.  Contraindication to MRI imaging, including any of the following:  Non-MRI compatible cardiac pacemaker or implantable defibrillator; Non-MRI compatible aneurysm clip or other metallic implants; Neural Stimulator (i.e., TENS unit); Any implanted or magnetically activated device (insulin pump); Any type of non-MRI compatible ear implant; Metal shavings in the orbits; Any indwelling metallic foreign body, shrapnel, or bullet; Any condition contraindicating MRI, including claustrophobia; Inability to follow breath hold instructions or to maintain a breath hold for >15 seconds; and Known hypersensitivity or contraindication to gadolinium contrast. All unwitnessed out of hospital cardiac arrest or any witnessed cardiac arrest in which return of spontaneous circulation (ROSC) is not achieved within 30 minutes or any neurological injury Evidence of anoxic brain injury on admission (including posturing, seizures, loss of brain stem reflexes) Use of IABP Septic, anaphylactic, hemorrhagic, or neurologic causes of shock Non-ischemic causes of shock/hypotension (pulmonary embolism, pneumothorax, myocarditis, tamponade, etc.) Known previous myocardial infarction, in the same territory as present AMI Active bleeding for which mechanical circulatory support is contraindicated. Patient has history of bleeding diathesis or coagulopathy (including heparin induced thrombocytopenia), or refusal to receive blood transfusions if necessary. Contraindication to intravenous systemic anticoagulation Mechanical complications of AMI (acute ventricular septal defect (VSD) or acute papillary muscle rupture) Known left ventricular thrombus for which mechanical circulatory support with Impella is contraindicated Mechanical aortic prosthetic valve or self-expanding TAVR (note: prior bioprosthetic surgical valve or balloon-expandable TAVR implanted >24 hours pre-procedure is acceptable) Known impaired renal function (creatinine clearance <30 ml/min/1.73 m2 by the MDRD formula) or on dialysis. History of intracerebral mass, aneurysm, arteriovenous malformation, or hemorrhagic stroke. Stroke or transient ischemic attack within the past six (6) months, or any permanent neurological defect. Gastrointestinal or genitourinary bleeding within the last two (2) months. Any major surgery (including CABG) within six weeks of enrollment. Patient has received any organ transplant or is on a waiting list for any organ transplant. Patient has other medical illness (e.g., cancer, dementia) with life expectancy of less than one year. Patient has a known hypersensitivity or contraindication to any of the required study medications or contrast that cannot be adequately premedicated. Patient with severe peripheral arterial disease in whom mechanical circulatory support cannot be safely established (or who require a smaller device such as an IABP). Severe known cardiac valvular stenosis or insufficiency, pericardial disease, or cardiomyopathy. Patient is a member of a vulnerable population or has any significant medical or social condition which in the investigator's opinion may interfere with the patient's participation in the study or ability to comply with follow-up procedures, including MRI (e.g. alcoholism, dementia, lives far from the research center, etc.). Current participation in other investigational device or drug study that has not reached its primary endpoint. Symptoms consistent with isolated right ventricular cardiogenic shock (this study is intended to enroll patients experiencing cardiogenic shock from predominant left ventricular dysfunction). Previous enrollment in this study.  Subject is currently hospitalized for definite or suspected COVID-19.  ANGIOGRAPHIC EXCLUSION CRITERIA: These are evaluated after the patient has provided signed Informed Consent and has undergone cardiac catheterization and PCI if indicated:  Left ventriculography or high-quality echocardiography (at least one of which is mandatory either before or after PCI, but in all cases before randomization) demonstrates severe mitral regurgitation with concerns of papillary muscle rupture, a ventricular septal defect, a pseudoaneurysm, aortic dissection or other mechanical complications of MI. Any unrevascularized left main or ostial right coronary artery stenosis >50%, which would preclude use of the delivery catheter. Presence of a non-stented coronary dissection with NHLBI grade >B upon completion of the PCI procedure.