Inclusion Criteria:  Between 18-75 years of age Signed informed consent form Clinical diagnosis of Parkinson's disease (according to 2016 edition of Chinese Parkinson's disease diagnostic criteria) Parkinson's disease duration of 1 year or more Hoehn & Yahr stage 1-4 (including) Patients have following 2 or more symptoms, which appear for at least 6 months and exist in recent 3 months: A. at least 25% of defecation feel strenuous; B. At least 25% of defecation was not massive or hard; C. at least 25% of defecation had incomplete feeling; D. at least 25% of defecation had anorectal obstruction; E. at least 25% of defecation needed manual assistance; F. defecation less than 3 times a week, with or without abdominal pain Patients are taking oral L-dopa (with or without Benserazide, carbidopa, and O-methyltransferase inhibitors) at least 4 weeks, and be able to tolerate a steady dose of dopamine agonists, monoamine oxidase B inhibitors, anticholinergics, and / or adamantine. Patients are taking stable dosage of anti-PD drugs, antidepressant drugs and antipsychotics for more than 1 month. Be able to tolerate the FMT infusion method such as endoscopy, colonoscopy, capsule, nasoduodenal tube insertion, etc. Be able to receive follow-up visit, follow-up examination and specimen collection on time  Exclusion Criteria:  Patients with Parkinson's syndrome and Parkinsonism plus syndrome History of cerebrovascular accident, brain injury, epilepsy and other brain injury The "opening" stage was Hoehn & Yahr 5 Patient received neurosurgical intervention or stereotactic brain surgery for Parkinson's disease Patients with organic lesions of digestive tract Patients had major abdominal surgery History of infectious diarrhea and took antibiotics in recent 2 weeks Patients infected with Clostridium difficile and other pathogens Patients with HIV or compromised immune system (such as congenital immunodeficiency or currently taking immunosuppressive drugs) Patients with uncontrollable basic diseases of digestive system Patients could not fully understand and sign the informed consent form Patients who were not considered suitable for inclusion in the study