Inclusion Criteria:  patients diagnosed with MS of all forms using any of the oral "DMDs" men and women older than 18 years signature of the Informed Consent to Participate in the Study  Exclusion Criteria:  minor patients (below 18 years of age) refusal to sign the Informed Consent to Participate in the Study refusal of blood samples taken beyond standard examinations  Criteria for exclusion from the study  non-compliance with the treatment regimen according to the decision of the attending physician non-participation in blood samples taken as part of standard examinations