Inclusion Criteria for Children (3 months to 5 years):  Male or female participants aged between ≥3 months of age and <5 years of age at Day -7. Written informed consent from participant/parent(s)/guardian(s). Participants and parent(s)/guardian(s) are willing and able to comply with study instructions, study visits, and procedures. Have a clinical diagnosis of AD according to the criteria of Hanifin and Rajka. Have AD involvement ≥ 5% Treatable % Body Surface Area (BSA) excluding the scalp and less than 40% BSA. Have an Investigator's Static Global Assessment (ISGA) score of Mild (2) or Moderate (3) at the screening visit. Have an Eczema Area and Severity Index (EASI) total score of ≥3 at Day -7. Have a minimum Observer Reported Itch Assessment score of 2 at Day -7.  Inclusion Criteria for Adult Caregiver (18-75 years)  Primary caregiver of the enrolled child participant, between ≥18 years of age and ≤75 years of age. Able to understand and cooperate with study procedures and give informed consent. Native English speakers or demonstrated fluency in English Evidence of a personally signed and dated informed consent document indicating that the participant has been informed of all pertinent aspects of the study. ISGA score of 0 or 1 of AD at the screening visit, and no reported diagnosis of Atopic Dermatitis  Exclusion Criteria for Children:  Has any clinically significant medical disorder, condition, disease (including active or potentially recurrent non-AD dermatological conditions and known genetic dermatological conditions that overlap with AD, such as Netherton syndrome) or clinically significant finding at screening that precludes participant's participation in study activities. Participants who are on systemic corticosteroids or immunosuppressive agents within 28 days of Day -7 (V01). Participants who are on topical AD treatment such as low-to-high-potency corticosteroids, topical calcineurin inhibitors (TCIs), antihistamines, antibiotics, sodium hypochlorite-based products, antibacterial soaps, bleach baths, diaper rash creams, lotions, ointments, powders, light therapy, and use of bland emollients on or overlapping with treatable AD-involved areas or on AD-involved within 7 days of Day -7 (V01). Participant agrees to refrain from applying diaper rash creams, lotions, ointments, powders, etc. where AD lesions are present. Participants who are or have been on crisaborole treatment regimen in the past. Allergy to polyurethane resin (strap/wristband component), skin nickel allergy, silicone, and/or adhesives. Has documented non-AD related insomnia, sleep apnea or other sleep-related disorders (e.g., narcolepsy, restless legs syndrome, circadian rhythm disorder). Participant has a known lack of efficacy to crisaborole. Participant scores <20 on the Childhood Asthma Control Test (ages 4-5) indicating poorly controlled asthma. If the participant has significant eczema at the location where the bilateral wrist or ankle devices will need to be worn, making the devices intolerable for the participant, and in the opinion of the participant or investigator would likely lead to noncompliance. If participant has a history of angioedema or anaphylaxis. Has a significant active systemic or localized infection, including actively infected. Has any planned surgical or medical procedure that would overlap with study participation. Participants with cardiac pacemakers, electronic pumps or any other implanted medical devices. Participants with AD lesions on the fingers or hands or within 2 cm of the mouth to prevent inadvertent ingestion of crisaborole.  Exclusion Criteria for Adult Caregiver:  Has any clinically significant medical disorder, condition, disease or clinically significant finding at screening that precludes Caregivers participation in study activities (e.g., sleep apnea, narcolepsy, etc.) History of regular alcohol consumption exceeding 7 drinks/week for females or 14 drinks/week for males (1drink=5ounces (150mL) wine, 12 ounces (360mL) of beer, or 1.5 ounces (45mL) of hard liquor) within 6 months of screening as disclosed by participant during evaluation. Current shift worker or travel across more than two time zones in the past 2 weeks, and/or during the study period. Has any planned surgical or medical procedure that would overlap with study participation. Participants who are investigational site staff members directly involved in the conduct of the study and their family members, site staff members otherwise supervised by the investigator, or participants who are Boston University (BU)/Boston Medical Center (BMC) employees directly involved in the conduct of the study. Allergy to polyurethane resin (strap/wristband component), skin nickel allergy, silicone, and/or adhesives. A female who is pregnant. The primary caregiver or share the same domicile of another child who has previously been or is currently enrolled in the study.