Inclusion Criteria:  Mild-moderate-to-severe secondary MR (as assessed by qualitative, semi-quantitative and/or quantitative echocardiographic assessment (Zoghbi, JASE 2017)) in the setting of all of the following (a-d, below):  Symptomatic functional (secondary mitral regurgitation defined as both: 1+ (mild) 2+ (Moderate), or 3+ (Moderate/Severe) Exacerbation of MR with exercise by at least one grade or 10 mm2 EROA Left Ventricular Ejection Fraction ≤50% by Simpson's biplane technique LVEDD >5.5 cm New York Heart Association (NYHA) Class II, III or ambulatory IV heart failure Stable heart failure medication regimen for at least 30 days prior to index procedure Patient deemed appropriate candidate for transcatheter mitral valve repair by the local multidisciplinary heart team Subject meets anatomic screening criteria as determined by angiographic screening at the time of the index procedure to ensure that implant can be sized and placed in accordance with the Instructions for Use Female subjects of child-bearing potential must have a negative serum βHCG test Age ≥ 18 years old The subject has read the informed consent, agrees to comply with the requirements, and has signed the informed consent to participate in the study  Exclusion Criteria:  Hospitalization in past three (3) months due to myocardial infarction, coronary artery bypass graft surgery, and/or unstable angina Evidence of transient ischemic attack or stroke within three (3) months prior to intervention Percutaneous coronary intervention in the last 30 days Subjects expected to require any cardiac surgery, including surgery for coronary artery disease or for pulmonic, aortic, or tricuspid valve disease within one (1) year Subjects expected to require any percutaneous coronary intervention within 30 days of the index procedure. Pre-existing device (e.g., pacing lead) in coronary sinus (CS) / great cardiac vein (GCV), or anticipated need for cardiac resynchronization therapy (CRT) within twelve (12) months Presence of a coronary artery stent under the CS / GCV in the implant target zone Presence of left atrial appendage (LAA) clot. Presence of primary renal dysfunction or significantly compromised renal function as reflected by a serum creatinine > 2.2 mg/dL (194.5 μmol/L) OR estimated Glomerular Filtration Rate (eGFR) < 30 ml/min Poorly controlled atrial fibrillation or flutter, with poor ventricular rate control (> 100 bpm resting HR), or other poorly controlled symptomatic brady- or tachy-arrhythmias Uncontrolled hypertension (BP > 180 mmHg systolic and/or >105 mmHg diastolic) or hypotension (BP < 90 mmHg systolic) at baseline Presence of severe mitral annular calcification Prior mitral valve surgery Presence of a mechanical mitral heart valve, mitral bio-prosthetic valve or mitral annuloplasty ring Echocardiographic evidence of intracardiac mass, thrombus, or vegetation Active endocarditis Severe aortic stenosis (aortic valve area <1.0 cm2) or severe aortic regurgitation Infiltrative cardiomyopathies (e.g., amyloidosis, hemochromatosis, sarcoidosis) Hypertrophic cardiomyopathy, restrictive cardiomyopathy, constrictive pericarditis, or any other structural heart disease causing heart failure other than functional mitral regurgitation Subjects with echocardiographic documentation of non-compaction cardiomyopathy with associated hypercontractility of the cardiac structures supporting the mitral annulus Hemodynamic instability requiring inotropic support or mechanical heart circulatory support Active infections requiring current antibiotic therapy Severe right ventricular failure or severe tricuspid regurgitation History of bleeding diathesis or coagulopathy, or subject who refuses blood transfusions Significant organic mitral valve pathology (e.g., moderate or severe myxomatous degeneration, with or without mitral leaflet prolapse, rheumatic disease, full or partial chordal rupture) Allergy to contrast dye that cannot be pre-medicated Pregnant or planning pregnancy within next 12 months. Chronic severe pathology limiting survival to less than 12-months in the judgement of the investigator Anticipated need of left ventricular assist device within twelve (12) months Currently participating or has participated in another investigational study where the study primary endpoint was not reached at the time of screening Patient requires emergent/emergency treatment for mitral regurgitation