Inclusion Criteria: ambulatuar or non -ambulatuar  All patients with diagnosed with Multiple Sclerosis. (Diagnosis of MS according to the revised McDonald Criteria 2017) An ability to understand and execute simple instructions. Aged 20-65 years old.  Exclusion Criteria:  patients with hearing, vision and cognitive problems. Pregnancy (self-reported) Orthopedic and other neurological disorders affecting upper limb movements (e.g., epileptic seizures) Contra-indication to physical activity (e.g., heart failure, severe osteoporosis) MS clinical relapse or treatment with corticosteroid therapy within 30 days prior to enrollment Started or stopped a disease-modifying therapy for MS within 30 days prior to enrollment