Inclusion Criteria:  Patients with non-segmental vitiligo of any age and gender.  Exclusion Criteria:  History of vitiligo treatment with topical, systemic or biological agents prior to the study for at least 3 weeks. Pregnancy and lactation. Infections Patients with other autoimmune diseases. Patients with chronic diseases: cardiac diseases, hepatic disorders, hematologic disease, chronic renal failure or malignancies.