Inclusion Criteria:  Individuals who meet all of the following criteria are eligible for enrollment as study subjects-  Subject must be able to understand and provide informed consent End stage renal disease (ESRD) on dialysis  United Network for Organ Sharing (UNOS) listed for a kidney transplant with any one of the following:  Current calculated panel reactive antibodies (cPRA) ≥ 99.9 percent awaiting deceased donor transplant Current cPRA >98 percent (with >5 years of waiting time) awaiting deceased donor transplant Current cPRA >98 percent with Human Leukocyte Antigen (HLA)-incompatible approved living donor and has not received a transplant after 1 year in a kidney paired exchange program Evidence of established immunity to Epstein-Barr virus (EBV) as demonstrated by serologic testing  Negative result of most recent tuberculosis (TB) testing or appropriately completed latent tuberculosis infection (LTBI) therapy.  Testing should be conducted using either a purified protein derivative (PPD) or interferon-gamma release assay (i.e. QuantiFERON-TB, T-SPOT.TB). Negative results from tests performed within 12 months prior to study entry are acceptable in the absence of any intervening exposure to TB.  Subjects with a positive test result must have completed appropriate therapy for LTBI.  Note: LTBI treatment regimens should be among those endorsed by the Centers for Disease Control and Prevention (CDC), url: https://www.cdc.gov/tb/topic/treatment/ltbi.htm Negative Food and Drug Administration (FDA)-approved test for human immunodeficiency virus (HIV) diagnosis (at screening or as documented in medical record, up to 12 months prior to screening)  Negative Hepatitis C antibody test at screening or as documented in medical record, up to 12 months prior to screening.  --If there is a history of treated hepatitis C or there is a suspected false positive hepatitis C virus (HCV) antibody test, then documentation of two consecutive negative HCV quantitative ribonucleic acid (RNA) polymerase chain reaction (PCR) tests separated by at least 6 months is required  Negative result for 2019-novel Coronavirus (2019-nCoV) by real-time reverse transcriptase- polymerase chain reaction (RT-PCR)  Subjects must have an echocardiogram within the previous 1 year without any of the following findings:  severe left ventricular hypertrophy (LVH) greater than mild LVH accompanied by diastolic dysfunction left ventricular ejection fraction <40 percent pulmonary hypertension defined as right ventricular systolic pressure >35 mm Hg or tricuspid regurgitant velocity >2.8 m/s Female subjects of reproductive potential must have a negative pregnancy test upon study entry All subjects of reproductive potential must agree to use contraception for the duration of the study  Subjects must have current vaccinations or documented immunity to:  varicella (chickenpox) measles hepatitis B pneumococcus influenza, and  varicella zoster (if ≥ 50 years old).  Note: If subjects require administration of either live or killed vaccines to meet eligibility requirements, they must wait at least 2 weeks between vaccination and the baseline visit (i.e., at least 4 weeks before initiation of therapy)  Living Donor Inclusion Criteria:  Living donors must meet all of the following criteria to be eligible-  Able to understand and provide informed consent for research Meets United Network for Organ Sharing (UNOS) requirements for kidney organ donation  Exclusion Criteria:  Individuals who meet any of these criteria are not eligible for enrollment as study subjects-  Inability or unwillingness of a subject to give written informed consent or comply with study protocol Known active current or history of invasive fungal infection, non-tuberculous mycobacterial infection Hepatitis B surface antigen or core antibody positive Serious uncontrolled concomitant major organ disease, excluding kidney failure Chronic respiratory failure Uncontrolled systemic hypertension Previous non-kidney solid organ transplant or bone marrow transplant Any infection requiring hospitalization and intravenous (IV) therapy within 4 weeks of screening or oral therapy within 2 weeks of screening History of positive result for 2019-novel Coronavirus (2019-nCoV) by real-time reverse transcriptase reverse transcriptase-polymerase chain reaction (RT-PCR) Primary or secondary immunodeficiency History of thromboembolism (except thrombosis of dialysis vascular access site) Subjects with myocardial infarction within 12 months of screening or cardiac dysrhythmias uncontrolled by medications History of plasma cell dyscrasia Known bleeding diathesis or coagulation abnormality History of active tuberculosis (TB) (even if treated) Malignancy within the last 5 years except treated basal and squamous cell cancer of the skin or treated cervical cancer in situ Women who are currently pregnant or nursing Alcohol, drug, or chemical abuse within 1 year Treatment with any investigational agent within 4 weeks (or 5 half-lives of investigational drug, whichever is longer) of screening Current treatment with other biological drug Current treatment with any medication which increases the risk of thromboembolic events including oral contraceptives Currently smoking tobacco Neutropenia (absolute neutrophil count <1000/microliter) or thrombocytopenia (platelet count <100,000/microliter) within 4 weeks prior to screening Alanine Aminotransferase (ALT) or aspartate aminotransferase (AST) ≥3 times upper limit of normal (ULN) or total bilirubin ≥ 2 times ULN  Past or current medical problems or findings from physical examination or laboratory testing not listed above, which, in the opinion of the investigator, may:  pose additional risks from participation in the study interfere with the subject's ability to comply with study requirements, or impact the quality or interpretation of the data obtained from the study.  Exclusion Criteria for Living Donors:  1. There are no exclusion criteria for living donors.