Inclusion Criteria:  > 18 years of age; Primary Parkinson's disease diagnosed according to British Brain Bank criteria (Hoehn and Yahr); Deep brain stimulator therapy; Sign the informed consent.  Exclusion Criteria:  Use of probiotics or probiotics during the study; Use antibiotics against intestinal bacteria at present or within the last 1 month; With cognitive dysfunction or mental illness; With severe diseases or is not expected to survive for more than a year; A history of gastrointestinal surgery; AIDS patients, hepatitis B/C positive.