Inclusion Criteria:  Aged 18 to 75 years, inclusive at Visit 1 Screen. Clinical diagnosis of Irritable Bowel Syndrome with Diarrhea (IBS-D) according to Rome III or IV criteria at Visit 1 Screen. Clinical laboratory evidence of BAM with at least one of the following results recorded within the past 5 years or to be performed at screen: Serum C4 ≥ 52 ng/mL; Fecal BA > 2337 µmoles / 48 hours; Total fecal BA > 1000 µmoles / 48 hours + 4 % primary BA; Fecal primary BA > 10%. Body mass index (BMI) 18.0 to 45.0 kg/m2, inclusive at Visit 1 Screen Understands the study procedures, is willing and able to comply with the study procedures, and is able to give informed consent If treated with any of the following medications, dosing must be stable for 30 days prior to Visit 1 Screen. Participant must agree to maintain the same dose of medication throughout the study: tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs).  Exclusion Criteria:  Pregnant or lactating Structural or metabolic diseases/conditions that affect the gastrointestinal system Use of the following medications at least 7 days prior to Visit 1 throughout the duration of the treatment period: IBS-D medications, including colestipol, cholestyramine, colesevelam, obeticholic acid, alosetron, ondansetron. Note: Participants may elect to withdraw from these medications at Visit 1 Screen. A 14-day washout will be required after which the patient may proceed with laboratory tests, bowel pattern diary and stool collection; GI medications including anti-nausea agents including trimethobenzamide, promethazine, prochlorperazine, dimenhydrinate, hydroxyzine; osmotic laxative agents including lactulose, sorbitol or PEGylated (PEG) solutions as Miralax and Glycolax; prokinetic agents including tegaserod, metoclopramide, prucalopride, domperidone, erythromycin, clarithromycin and azithromycin; serotonin 5-HT3 antagonists including alosetron, ondansetron, tropisetron; drugs with a known pharmacological activity at 5-HT4, 5-HT2b or 5-HT3 receptors including tegaserod, ondansetron, granisetron and tropisetron; all narcotics including codeine, morphine, and propoxyphene, either alone or in combination; anti-cholinergics including dicyclomine, hyoscyamine, propantheline; antimuscarinics; tramadol; peppermint oil; systemic antibiotics and antibiotics directed at colonic flora including rifaximin and metronidazole Use of central nervous system (CNS) stimulant medications, including methylphenidate, atomoxetine, modafinil, amphetamines or phentermine. Clinically relevant changes in dietary, lifestyle, or exercise regimen within 30 days prior to Visit 1 Screen and throughout the duration of the study Any colonic or major abdominal surgery including bariatric surgery, gastric banding, stomach surgery and intestinal or colonic surgery. Procedures such as appendectomy, cholecystectomy, hysterectomy, caesarean section, or polypectomy are allowed as long as they have occurred at least 3 months prior to Visit 1 Screen. History of colorectal cancer, inflammatory bowel disease, diverticulitis, ischemic colitis, microscopic colitis or celiac disease. History of organic abnormalities of the GI tract, intestinal obstruction, stricture, toxic megacolon, GI perforation, or impaired intestinal circulation. Other GI diseases such as GI bleeding or ulcerations. History of cerebrovascular disease including stroke, transient ischemic attack (TIA), acute coronary syndrome, myocardial infarction or unstable angina. Clinically significant cardiac history or presence of electrocardiogram (ECG) findings at Visit 1 Screen: Abnormal heart rate < 40 or > 100 beats per minute; corrected QT interval (QTc interval) > 470 milliseconds (ms); QRS interval ≥ 110 ms; PR interval ≥ 220 ms Hepatic dysfunction including abnormal serum alanine aminotransferase (ALT) or aspartate transaminase (AST) > 3 × upper limit of normal (ULN)); total direct bilirubin > 2 × ULN, or alkaline phosphatase > 2 × ULN at Visit 1 Screen Clinically significant renal insufficiency including serum creatinine > 2.5 mg/dL at Visit 1 Screen History of severe head injury or history of seizures History of suicide attempt or a hospitalization for a major psychiatric condition within 1 year prior to Visit 1 Screen. At Visit 1 Screen, participants will complete the Hospital Anxiety and Depression questionnaire. If either score for anxiety or depression individually exceeds 8, the score will be discussed. The participant will be advised whether to participate or whether to see their primary care physician. History of alcohol use disorder or substance use disorder within 2 years of Visit 1 Screen. Significant history or clinical manifestation of any endocrine, allergic, dermatological, hepatic, renal, hematological, pulmonary, GI, neurological or psychiatric disorder, malignancy (with the exception of treated basal cell carcinomas), or any other condition that would prevent the individual from participating in the study due to risk to the scientific validity of study assessments or to personal well-being of the participant. Participants must use one highly effective method of contraception for 30 days before the study through 90 days after study completion for males and through 30 days after study completion for females. Highly effective methods of contraception include: Oral, implantable, transdermal or injectable hormonal contraceptives; standard intrauterine device or vaginal ring; Male or female condoms and diaphragms used with spermicide; abstinence from heterosexual intercourse; female partners exclusively sexually active with a surgically sterilized male partner. Females who are surgically sterile having experienced a prior hysterectomy, bilateral salpingectomy, or bilateral oophorectomy or postmenopausal (defined as12 consecutive months with no menses) are not considered to be of childbearing potential. Participated in another clinical study within 30 days or 5 half-lives (whichever time period is longer) or 6 weeks for biologic therapies prior to Visit 1 Screen