Inclusion Criteria:  previous diagnosed primary glomerular disease based on both clinical and renal biopsy findings an estimated glomerular filtration rate ≥15 ml/min/1.73m2 proteinuria ≥2.0 g/24h  Exclusion Criteria:  secondary glomerular disease acute kidney injury acute or chronic inflammation malignancy uncontrolled hypertension with systolic blood pressure higher than 160 mmHg symptomatic hypotension advanced heart failure history of non-compliance, dementia or depression