Inclusion Criteria:  Patients 18 years and over at the time of consent Willing and able to provide written informed consent and comply with study procedures Presenting with symptoms of infection, tissue injury, inflammatory disorders. This includes but not limited to : respiratory tract infection (upper and lower), rheumatoid arthritis, Lupus, burns, trauma, inflammatory bowel disease.  Exclusion Criteria:  The patient is currently receiving or has received within the past thirty (30) days of the study visit an experimental biologic or drug including either treatment or therapy. Skin lesions or conditions that would preclude a fingerstick and/or a venous blood draw. Patient has previously participated in this study Any patient with critical illness or requiring a time critical intervention Patient with end of life or palliative care Patient suffering from the following conditions: Myeloma, monoclonal gammopathy, extreme lipaemia Patient is deemed medically unfit to participate.