Inclusion Criteria:  (1）Children with SLE diagnosed by the SLICC classification criteria for systemic lupus erythematosus (2012); (2) Since diagnosed of SLE to follow-up termination, inpatient and/or outpatient follow-up at the research centers shall be carried out at least twice a year, the interval of follow-up is ≤3-6 months, and the total follow-up time is ≥1 year; (3) All children or guardians signed an informed consent file before inclusion.  Exclusion Criteria:  the treatment plan is unknown; Excluding deaths caused by other diseases follow-up was interrupted; Follow-up time is less than 1 year, or interval is more than 6 months.