Inclusion Criteria:  Subjects must be diagnosed with clinically significant dry eye. Subjects have no active ocular disease or allergic conjunctivitis. Subjects must not be using any topical ocular medications within two weeks prior to enrollment. Subjects must be willing and able to follow instructions. Subjects must have voluntarily agreed to participate in the study by signing the statement of informed consent. Subjects must meet plasma donor criteria as established by University of Rochester Transfusion Medicine & Blood Bank.  Exclusion Criteria:  Is pregnant at the time of enrolment in the study determined by urine pregnancy test. Is currently on a course of antibiotics Is considered by the Investigator to not be a suitable candidate for participation and are not at risk for glaucoma. Is considered by the University of Rochester Transfusion Medicine & Blood Bank not a suitable candidate for blood donation.