Inclusion Criteria:  Age ≤ 25 years at time of enrollment  High-risk AML, as defined by one of the following:  a. AML in CR1 (defined as <5% blasts in BM by morphology and flow cytometry) having at least one of these high-risk features: i. Mutations associated with high risk disease (Appendix A). Other high-risk features not explicitly stated in Appendix A can be considered after discussion/approval with the protocol chair/team ii. MRD-positive at the end of Induction I chemotherapy (defined as flow cytometry ≥ 0.1% blasts) b. AML in ≥CR2 (defined by <5% blasts in BM by morphology and flow cytometry)  Recovery from prior cycle of chemotherapy as defined by an absolute neutrophil count ≥ 500/mm3 AML secondary to select germline marrow failure disorders (with exception of Fanconi Anemia) may be eligible but require approval from Protocol Chairs prior to enrollment. Performance status ≥70% (Lansky for <16 years; Karnofsky for ≥16 years)  Adequate major organ system function as demonstrated by:  Renal: Creatinine clearance (CrCl) ≥60 mL/min/1.73m2 by Cockcroft-Gault formula, Schwartz formula, or nuclear GFR study (Table 3) Hepatic: Total bilirubin <2 mg/dL (unless due to Gilbert syndrome) and ALT and AST < 5x ULN Cardiac: LVEF at rest ≥50% or SF ≥27% (by MUGA or ECHO) Pulmonary: DLCO, FEV1, and FVC ≥ 50% of predicted corrected for hemoglobin. For patients <7 years of age or those unable to perform PFTs: O2 Sat >92% on room air by pulse oximetry and on no supplemental O2 at rest The patient, patient's parent, guardian, or legal representative can provide written informed consent  Exclusion Criteria:  Active extramedullary disease Unresolved/ongoing and serious viral, bacterial, or fungal infection despite appropriate treatment Positive pregnancy test in a female of child-bearing potential (FCBP) Inability to comply with medical therapy or follow-up Prior allogeneic transplant Patients with Fanconi Anemia and Down syndrome