Inclusion Criteria:  Ability to provide written informed consent Ability and willingness to comply with the study procedures and duration requirements, including connection of the device to the left wrist/hand and maintaining relatively motionless during the session 18 years of age or older Planned to undergo a minimum of three (3) hemodialysis sessions within the two (2) weeks following enrollment.  Exclusion Criteria:  Females who are pregnant or breastfeeding Undergone an amputation of the left upper extremity Subjects with left arm hemodialysis access only Diagnosed with dextrocardia Subjects who have a pacemaker Subjects who have any other underlying condition that would inhibit completion of participation in the study, per Investigator opinion