Inclusion Criteria:  adult patient, 18 years of age diarrhea and/or abdominal pain. Presence of C. difficile toxins in feces Patient having dated and signed informed consent.  Exclusion Criteria:  pregnant or nursing women adult under guardianship Ileus Peritonitis Pseudomembranous colitis Hemodynamic instability Fever ≥ 38.5°C Shivers Respiratory failure Leukocytosis > 15x109/L Serum creatinin >50% reference values) Serum lactate > 5mM Serum Albumine < 30g/l Other diarrhea cause Humoral immunodeficiency