Inclusion Criteria:  For human treatment/safety cohort  Residents of the study area Male or female weighing more than 15kg Adult able to provide written consent Minors aged 12 to 17 able to provide assent Parent/guardian's able to provide consent for minors Negative pregnancy test for women aged between 13 and 49 Agreement to adhere to study visits and procedures  For pediatric active cohort:  Children in the age of highest burden at the time of enrollment (under 5 years of age in Mozambique or 5-15 in Tanzania) Residents of the study area Parent/guardian's able to provide consent for minors Minors aged 12 to 15 in Tanzania able to provide assent  For cross sectionals  Residents of the area for at least 3 months prior to enrolment Parent/guardian's consent for minors Ability to provide assent for minors aged 12 to 17 Written consent from adults  For livestock treatment:  Owner/guardian able to provide consent Animal expected to spend at least one week every study month inside the cluster border  Exclusion Criteria:  5.2.1. For human treatment/safety cohort:  Known hypersensitivity to ivermectin or albendazole Risk of Loa as assessed by travel history to Angola, Cameroon, Chad, Central African Republic, Congo, DR Congo, Equatorial Guinea, Ethiopia, Gabon, Nigeria or Sudan Pregnant women Lactating women in the first week postpartum Children < 15 kg Currently participating in another clinical trial Unwilling to provide informed consent or assent Unwilling to adhere to study visits and/or procedures Severely ill either self-reported or in the eyes of the investigator, e.g. defined as need for clinical care, or active or progressive disease interfering with activities of daily living. If in doubt, these criteria can be confirmed after a call with either the site PI/MD/safety officer against a pre-defined list. Currently under treatment with inhibitors of CYP3A or P-gp or other drugs that can interfere with the study  For incidence cohort:  Non-residents Currently enrolled in other clinical trial  For cross sectionals  • Non-residents  For livestock treatment  Received ivermectin three weeks than four weeks ago Intention to milk or slaughter the animal for human consumption during the withdrawal period Calves under 8 weeks and piglets under 6 weeks of age