Inclusion Criteria:  Patients who meet the following inclusion criteria will be eligible to participate in the study:  Patients who meet RA standards in 1987 and 2010 or ERA standards in 2012; Age > 18 years old; the extrapulmonary manifestations of RA were stable; Patients with NSAIDs tolerance; DAS28-ESR is highergreater than 2.6.  Exclusion Criteria:  Patients who meet any of the following criteria will be excluded from the study:  Patients with acute and chronic infection; Platelet count < 80*10^9/L, or white blood cell < 3*10^9/L; ALT or AST is 2 times higher than the upper limit of normal value; Renal insufficiency: serum Cr ≥ 176 umol/L; Pregnant or lactating women (breastfeeding); Have a history of malignant tumor (the cure time is less than 5 years); Patients with severe hypertension and cardiac insufficiency; Other diseases or conditions in which immune suppressants cannot be used; People who are allergic to TF.