Inclusion Criteria:  Patients 19 years of age or older who are undergoing hemodialysis during renal replacement therapy Patients undergoing arteriovenous fistula formation and hemodialysis to the affected area Patients who have the ability and willingness to consent to participate in the clinical study, have signed the consent form in accordance with the appropriate procedures, and can visit and participate in the clinical study as planned  Exclusion Criteria:  Patients who failed to start hemodialysis with an arteriovenous fistula within 3 months Patients who have had stent implantation or surgery during the study period due to cardiovascular disease Patients with severe hepatic impairment Patients with coagulopathy and liver disease associated with clinically significant bleeding risk Patients with clinically significant bleeding or bleeding risk Patients who underwent artificial heart valve replacement requiring anticoagulant administration Patients with pulmonary embolism who are hemodynamically unstable or require thrombolysis or pulmonary embolization. Pregnant and lactating women