Inclusion Criteria:  men and women aged over 18 years of age on the date of informed consent diagnosed CF patients not transplanted and not on the transplant waiting list able to participate in the proposed training programs (especially without cardiac contraindication) able to understand and respect the protocol and its requirement who signed the consent prior to any other procedure protocol  Exclusion Criteria:  major patients under guardianship / curatorship / legal protection pregnant patients dialysis patients patients with a severe exacerbation at the time of inclusion patients for whom a new modulating treatment (eg.: Kaftrio®, Kalydeco®, Symkevi®, etc.) has been implemented in the 4 weeks preceding inclusion patients with pulmonary arterial hypertension (≥ 25 mmHg) patients unable to complete the entire program