Inclusion Criteria:  Female patients with ductal carcinoma (stage 1 to 3) undergoing primary potentially curative unilateral mastectomy. Older than 18 years ASA I-III  Exclusion Criteria:  Weight < 50 kg BMI > 35 Allergy to local anaesthetic or dexmetomidine Contraindications to NSAIDs use Local infection over block site Coagulopathy Preexisting chronic pain Pregnancy Autoimmune disease Inability to give informed consent