Inclusion Criteria:  Clinical indications for prostate biopsy to be performed under local anesthesia based on an elevated prostate-specific antigen (PSA) level (≤30 ng/mL) or abnormal digital rectal exam Willingness to sign informed consent and adhere to the study protocol  Exclusion Criteria:  Prior prostate biopsy performed in the last 5 years; OR prior diagnosis of prostate cancer Acute prostatitis within the last 6 months Current non-urologic bacterial infection requiring active treatment with antibiotics Unfit to undergo prostate biopsy under local anesthesia Prior definitive therapy for prostate cancer, such as radiation therapy or partial gland ablation Contraindication to prostate MRI (claustrophobia, pacemaker, chronic kidney disease)