Inclusion criteria:  Patient followed up in vascular medicine departement at Montpellier University Hospital for primary lymphedema of lower limbs, who carries the CELSR1 mutation with codon stop or amino acids substitution mechanism. Relatives to the index case who carry the mutation for the segregation study.  Exclusion criteria:  Patients who carry another mutation than CELSR1 responsible for primary lymphedema Syndromic form of primary lymphedema Patient not followed up at Montpellier University Hospital.