Inclusion Criteria:  Patients with type 2 diabetes mellitus having proteinuria associated with macroscopic or microscopic haematuria. Patients with type 2 diabetes mellitus with nephrotic syndrome appearing in the early stages of DM (less than 10 years of diagnosis) in absence of retinopathy or neuropathy. Patients with type 2 diabetes mellitus with unexplained renal failure or rapidly progressive renal dysfunction within few weeks or months. Patients with type 2 diabetes mellitus with symptoms and signs suggestive of systemic disease that may affect the kidney as SLE, vasculitis, multiple myeloma or lymphoma. Patients with type 2 diabetes mellitus with rapidly progressive glomerulonephritis.  Exclusion Criteria:  Patients with type 1 diabetes mellitus. DM with clinically, laboratory or radiologically evident CKD due to either chronic pyelonephritis, polycystic kidney disease or chronic obstructive nephropathy. DM with end stage renal disease (ESRD) with bilateral small kidneys. Patients with any contraindication to renal biopsy (systemic infections, bleeding tendency, low platelets, decrease prothrombin concentration).