Inclusion Criteria:  Ability to understand and be willing to sign an informed consent form. Male or female, ≥ 18 years old at the time of screening.  Diagnosis of histologically or cytologically confirmed:  Locally advanced or metastatic cancer (all solid tumours). Patients must be considered refractory or intolerant to standard (SOC) therapies or have refused standard therapy (Phase 1a, Dose Escalation Monotherapy), OR Locally advanced or metastatic cancer (ovarian or bladder cancer). Patients must be considered refractory or intolerant to standard (SOC) therapies or have refused standard therapy (Phase 1b, Dose & Disease Expansion Combination Arms, Arms 1 & 2), OR High-grade glioma, such as glioblastoma multiforme (GBM) that are either: Newly diagnosed and are undergoing, or are planned to undergo, 42 days of standard of care (SOC) chemoradiation therapy as per part 1 of the eviQ protocol 3364 v.1. Patients successfully enrolled will receive a subsequent combination of NTX-301 and Temozolomide on day 1 of their first 28-day cycle of part 2 of the eviQ protocol 3364 v.1. This combination arm replaces the Temozolomide monotherapy SOC maintenance therapy as described in Part 2 of the eviQ protocol 3364 v.1. In order to prevent any potential delays after radiotherapy, patients can be enrolled at any time during Chemoradiation (eviQ Part 1). In order to commence the TMZ combination arms the patient is required to complete the full 42 days of eviQ part 1, and also receive their first dose of the TMZ combination arm within the screening window. This timing can be adjusted based on medical need on a patient-by-patient basis as per the discretion of the principal investigator together with the approval of the medical monitor (Phase 1b, 2a, Dose & Disease Expansion Combination GBM (optional) Arm, Arms 3 & 4)  Note: patients must also have:  a. At least one measurable disease lesion per RECIST 1.1 &/or RANO criteria.  Eastern Cooperative Oncology Group performance status of 0 to 2 for Phase 1a, and 0 to 1 for Phase 1b, 2a. Able to take oral medications and willing to record daily adherence to the study drug. QT interval corrected using the Fridericia method (QTcF) ≤ 450 msec for males and ≤ 460 msec for females at screening and on Day 1, prior to dose administration (the mean of triplicate measurements will be used to determine eligibility).  Evidence of adequate hepatic function at screening, as defined by the following:  AST and ALT ≤2.5 × upper limit of normal (ULN) (≤5 × ULN if liver metastases are present); and Total bilirubin ≤1.5 × ULN (< 2.0 x ULN for subjects with liver metastases or documented Gilbert's syndrome).  Adequate haematology laboratory assessment at screening, as defined by:  Absolute neutrophil count ≥1.00 x109/L; Haemoglobin ≥90 g/L; and Platelet count ≥100 x109/L. Evidence of adequate renal function, as defined by a calculated creatinine clearance ≥50 mL/min using the Cockcroft-Gault equation or 24-hour urine collection with plasma and urine creatinine concentrations respectively. Adequate coagulation laboratory assessments (i.e., within normal reference range values) at screening, in the opinion of the Investigator.  Female patients must be:  Of non-child-bearing potential i.e., surgically sterilized (hysterectomy, bilateral salpingectomy, bilateral oophorectomy at least 6 weeks before the Screening visit) or postmenopausal (where postmenopausal is defined as no menses for 12 months without an alternative medical cause and a follicle-stimulating hormone level consistent with postmenopausal status, per local laboratory guidelines), or Of child-bearing potential, must agree not to attempt to become pregnant, must not donate ova, and, if engaging in sexual intercourse with a male partner, must agree to use an acceptable method(s) of contraception from signing the consent form until at least 45 days after the last dose of study drug. Male patients must agree not to donate sperm and if engaging in sexual intercourse with a female partner who could become pregnant, must agree to use an acceptable method of contraception from signing the consent form until at least 90 days after the last dose of study drug Estimated life expectancy of at least 3 months, in the opinion of the Investigator. Willing and able to comply with all scheduled visits, treatment plans, laboratory tests, and other study procedures.  Exclusion Criteria:  Investigational agents, including hypomethylating agents, in the past 5 half-lives Patients with symptomatic brain metastases. Uncontrolled pleural effusion(s), pericardial effusion or ascites. Note: if they are controlled with recurrent drainage procedures, patients will be eligible for enrolment.  Evidence of abnormal cardiac function as defined by any of the following:  Myocardial infarction within 6 months of Cycle 1, Day 1 Symptomatic congestive heart failure (New York Heart Association > class II) Unstable angina Cardiac arrhythmia requiring medication. Unable to swallow oral medications. Gastrointestinal (GI) conditions that, in the opinion of the Investigator, could affect the absorption of NTX-301 History of bowel obstruction, abdominal fistula, gastrointestinal perforation or intra-abdominal abscess within 6 months of the first administration of NTX-301 (Cycle 1, Day 1) (unless otherwise approved by the Investigator).  Use of any herbal or prescription medications, or consumption of foods known to be strong inhibitors of cytochrome P450 3A (CYP3A) enzymes within 7 days prior to the first administration of NTX-301 (Cycle 1, Day 1). These include (but are not limited to):  Medications: refer to eMIMS Australia (www.emims.com.au) Foods: Grapefruit or Seville orange (or grapefruit- or Seville orange-containing products, including juices). Use of any herbal or prescription medications known to be strong inducers of CYP3A enzymes within 7 days prior to the first administration of NTX-301 (Cycle 1, Day 1) (refer to eMIMS Australia (www.emims.com.au)). Clinically significant active infection within 2 weeks of the first dose of NTX-301 (Cycle 1, Day 1). Positive test results for active human immunodeficiency virus (HIV-1 or HIV-2), hepatitis B surface antigen (HBsAg) or hepatitis C virus (HCV) antibodies at the Screening visit.  History of other malignancy within the past 2 years, with the following exceptions:  Malignancy treated with curative intent and with no known active disease present for ≥ 2 years before enrolment and felt to be at low risk for recurrence by the treating physician. Adequately treated non-melanoma skin cancer or lentigo malignancy without evidence of disease. Adequately treated cervical carcinoma in situ without evidence of disease. Adequately treated breast ductal carcinoma in situ without evidence of disease. Prostatic intraepithelial neoplasia without evidence of prostate cancer. Adequately treated urothelial papillary non-invasive carcinoma or carcinoma in situ.  Major surgery within 28 days of Cycle 1, Day1, with the following exceptions:  a. Major surgical procedures ≤28 days of beginning study drug, or Minor surgical procedures ≤7 days. No waiting required following port-a-cath placement or for venous access. Planned elective surgery unrelated to the patient's oncologic diagnosis, such as hernia repair, may be allowed, at the discretion of the Investigator, as long as it was performed at least 2 weeks prior to starting NTX-301, and the patient has recovered fully from this procedure.  Received cancer-directed therapy within the following timeframes:  Anti-tumour therapy (chemotherapy, antibody therapy, molecular targeted therapy, hormonal therapy or investigational agent) within 28 days or (unless 5 times the half-life is shorter than 28 days); Note: concurrent use of hormone deprivation therapy for hormone-refractory prostate cancer, bisphosphonate or denosumab for skeletal related events per institution guideline is permitted. Wide field radiation administered ≤28 days or limited field radiation for palliation ≤7 days prior to starting study drug or has not recovered from side effects of radiation therapy. Receiving treatment with any other concurrent investigational device(s) or conventional agent(s) within 28 days (unless 5 times the half-life is shorter than 28 days) of Cycle 1, Day 1.  Adverse Events due to investigational or conventional agents >4 weeks earlier that have not recovered to a severity of Grade 0 or Grade 1 (per Common Terminology Criteria for Adverse Events (CTCAE) version 5.0 or higher), with the exception of alopecia.  Notes (applies to Phase 1a, dose levels 3-5 and Phase 1b only):  i. Patients with chronic Grade 2 toxicities may be eligible per discretion of the Investigator and Sponsor (e.g., Grade 2 chemotherapy induced neuropathy).  ii. Grade 2 or 3 toxicities from prior anti-tumour therapy that are considered irreversible - defined as having been present and stable for > 6 months (such as ifosfamide-related proteinuria) may be allowed if they are not otherwise described in the exclusion criteria AND there is agreement to allow by both the Investigator and Sponsor  For women of childbearing potential, a positive pregnancy test at screening, or on Day 1, prior to dose administration. Pregnant or breast-feeding (or planning to breastfeed while on study through 15 days after the last dose of study drug. Hypersensitivity or other clinically significant reaction to the study drug or its inactive ingredients. Known substance abuse or medical, psychological, or social conditions that, in the opinion of the Investigator, may interfere with the patient's participation in the clinical study or evaluation of the clinical study results. Any other condition or prior therapy that in the opinion of the Investigator would make the patient unsuitable for this study, including inability to cooperate fully with the requirements of the study protocol or likelihood of noncompliance with any study requirements