Inclusion Criteria:  Patients aged ≥16 years at index date. Patients with records of receiving high dose ICS or high dose ICS/LABA and diagnosed as asthma (ICD-10 code: J45 or J46 ) during baseline period. High dose ICS and high dose ICS/LABA will be defined in the appendices (Table 6-9). Patients who had visit histories at least one visit during baseline period, at least two visits during outcome period and at least one visit after outcome period. Patients who had a total of 12 weeks of OCS prescribed during the baseline period including the index date.  Exclusion Criteria:  1. Patients diagnosed with selected autoimmune diseases during the baseline period because OCS is used as a therapeutic agent for these disease. Autoimmune disease will be identified by following ICD-10 code (M30, M05, M06, L93, M32, K50, K51, K52, N04).