Inclusion Criteria:  At least 6 months history of moderate or severe PPP, as defined by PPPASI ≥12 and PPPGA ≥3 at screening Males and females must be willing to use birth control as indicated  Exclusion Criteria:  Moderate to severe psoriasis covering ≥10% of total body surface area (BSA) at screening Breastfeeding or pregnant Known immunodeficiency or subject is immunocompromised Active/latent infection with HBV, HCV, HIV, SARS-CoV-2 or TB Any topical medications for PPP excluding emollients within two weeks of randomization and systemic therapies (including phototherapy) within 4 weeks of randomization