Inclusion Criteria:  Age: 20-40 years old to constitute a young study population BMI: 19-27 kg/m2 to constitute a normal/healthy weight population Weight: 133lbs or more Subjects must be willing and able to consume a standardized breakfast bar containing cashews and dates (Larabar). Subjects must be willing to consume oral dietary supplement versions of spermidine, 1-methlynicotinamide, palmitoylethanolamide, and oleoylethanolamide. Subjects must be willing and able to undergo blood draws at the UC Davis Ragle Nutrition Center at 0, 1, 2, and 4 hours after supplementation with spermidine, niacinamide, palmitoylethanolamide, and oleoylethanolamide.  Exclusion Criteria:  Smoker Anemia Documented chronic diseases including diabetes, thyroid disease, metabolic syndrome, cancer, autoimmune diseases, or previous cardiovascular events Any inflammatory bowel disease including IBS, Crohn's Disease, Celiac Disease Any allergy or sensitivity to wheat, gluten, or soy products Consumption of >1 alcoholic drink/day Current consumption of any probiotic, prebiotic, or dietary supplements Extreme dietary or exercise patterns Recent weight fluctuations (greater than 10% in the last six months) Regular use of over-the-counter allergy or pain medications (>1/week) Taking prescription lipid medications (e.g. statins) or other supplements known to alter lipoprotein metabolism such as isoflavones. Use of any form of hormonal birth control including oral contraception pills, hormonal IUDs or rings, or hormonal birth control patches Illness such as flu or cold of any kind within the last two weeks Allergy to components of standardized breakfast bar (cashew/dates) Changes to any of the above during the study period.