Inclusion Criteria:  Willing to participate in the study and provide written informed consent. Male and female adults aged > 18 years. History of cirrhosis and at least 1 documented prior episode of overt hepatic encephalopathy within 24 weeks prior to Screening; A PHES ≤ -4 during Screening MELD-Na score of <20 at Screening Support of a primary caregiver who is able and willing to give written informed consent.  Exclusion Criteria:  Hospitalization or serious medical condition History or presence of Child's Pugh class C, hepato-renal syndrome(s), refractory ascites or spontaneous bacterial peritonitis (SBP) History of a portosystemic or a transjugular intrahepatic portosystemic shunt (TIPS) placement; Expectation of a liver transplant during the study Screening Alcohol Use Disorders Identification Test (AUDIT) score ≥8