Inclusion Criteria:  Weigh at least 50kg (females) or 55kg (males) and have a BMI between 20.0 kg/m2 - 30.0 kg/m2. Subjects having no ulceration, damage, sunburn, redness, rash, acne, folliculitis, pigmentation, uneven skin tone, excessive freckles on the skin of the target application area and fever.  Exclusion Criteria:  An abnormality related to the comprehensive physical examination, laboratory test, 12-lead ECG, and other diagnostic tests and which is determined by the investigator as clinically significant (CS). A history of CS diseases of heart, liver, lung, kidney, digestive tract, blood, or neuropsychiatric system. Intolerance to venipuncture for blood collection and/or having blood or needle phobia.