Inclusion Criteria:  KCNQ2 mutation was confirmed by WES, Panel and other gene tests; Clinically diagnosed as epilepsy; KCNQ2 mutation was identified as pathogenic or possibly pathogenic according to ACMG pathogenicity rating standard; Age and gender are not limited; No abnormal birth history; Informed consent and willingness to follow up  Exclusion Criteria:  Patients with KCNQ2 mutation without epilepsy; Other possible pathogenic gene mutations except KCNQ2; Large cross-gene deletions or duplications including KCNQ2; Unable to participate in the study follow-up