Inclusion Criteria:  Subjects who voluntarily join the study, sign the informed consent form, and have good compliance. Aged from 18 to 75 years; Eastern Cooperative Oncology Group (ECOG) performance status score: 0-1; at least 3 months expected survival period. Subjects with relapse advanced malignant solid tumors clearly diagnosed by pathology and / or cytology, lack of conventional effective treatment methods. The function of main organs is normal. Subjects need to adopt effective methods of contraception.  Exclusion Criteria:  Subjects with other malignancies currently or suffered within 3 years. The following two conditions can be enrolled: other malignant tumors treated with a single operation to achieve disease-free survival (DFS) for 5 consecutive years; cured cervical carcinoma in situ, non-melanoma skin cancer and superficial bladder tumors[ Ta (non-invasive tumor), Tis (carcinoma in situ) and T1 (tumor infiltrating basement membrane)]. Subjects with multiple factors affecting oral administration. Subjets with unhealed toxicity above Grade 1 Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0 due to previous antitumor treatment. Subjects who have received major surgical treatment, open biopsy or obvious traumatic injury within 28 days before first administration. Subjects with long lasting wounds or fractures. Subjects with a history of psychotropic drug abuse unable to quit or with mental disorders. Subjects with any severe and/or uncontrolled disease. Subjects who have received surgery, chemotherapy, radiotherapy or other anticancer therapies 4 weeks before the first administration ( 2 weeks for brain radiotherapy ). Subjects who have taken Chinese patent medicines with anti-tumor indications in the drug instructions that National Medical Products Administration (NMPA)approved within 2 weeks before the first administration. Subjects with pleural effusion, pericardial effusion or ascites that cannot be controlled and need repeated drainage. Subjects with known central nervous system metastases and/or cancerous meningitis. Subjects who have participated in other clinical studies within 4 weeks before the first administration. According to the judgment of the investigators, there are accompanying diseases that seriously endanger the safety of patients or affect the completion of the study.