Inclusion Criteria:  Diagnosis of PCD  Clinical features consistent with PCD PLUS At least 1 diagnostic test consistent with PCD:  i) Biallelic pathogenic variants in PCD-associated genes identified by genetic panel testing including deletion/duplication analysis; ii) Ciliary ultrastructural defect by transmission electron microscopy known to be disease-causing, including outer dynein arm defects, outer dynein arm plus inner dynein arm (IDA) defects, IDA defects with microtubular disorganization and absent central pair  Age ≥ 6 years At least one course of antibiotics (oral or IV) in the prior year prescribed to treat new or increased respiratory symptoms Smart phone and/or internet access available in home Informed consent provided by participant or parent/guardian, with assent provided as applicable  Exclusion Criteria:  Acute course of antibiotics for respiratory symptoms completed <14 days prior to enrollment or Visit 1 (evaluated at enrollment and Visit 1; visit may be rescheduled >14 days after completion of antibiotics) Developmental or cognitive disability that would impair ability to complete PRO instruments or perform spirometry Congenital heart disease OTHER THAN repaired or resolved atrial septal defect (ASD) or ventricular septal defect (VSD) Asplenia or functional asplenia Co-existing non-pulmonary disease that, in the opinion of the investigator, could have significant impact on lung function or health-related quality of life (e.g., severe scoliosis) or overall health status (e.g., cancer, severe renal disease) Listed for or post-lung transplantation