Inclusion Criteria:  Age from 18 to 35 y.o. Indications for administration of estradiol valerate/ dienogest for the purpose of oral contraception. Patients who did not take estradiol valerate/ dienogest for at least one month before enrollment into the study. Signed informed consent to participate in the study  Exclusion criteria  Participation in an investigational program with interventions outside of routine clinical practice. Contraindications to estradiol valerate/ dienogest according to the local market authorization. Any medical and non-medical reasons that according to the physician's judgment may prevent patient's participation in the non-interventional study.