Inclusion Criteria:  Age ≥ 18 years old, no gender limit; First episode of STEMI (diagnostic criteria: ischemic chest pain lasting ≥30min; ST-segment elevation in two or more adjacent leads on the ECG or new left bundle branch block; with or without elevated myocardial markers), The onset time is within 12 hours, and emergency interventional treatment is planned; Agree and cooperate to participate in this research.  Exclusion Criteria:  Old myocardial infarction; Killip grade of cardiac function ≥ grade III or cardiogenic shock; Systolic blood pressure ≤100mmHg; Bradycardia, HR<60pbm, or AVB above II degree; Past history of asthma or severe COPD; Severe liver and kidney dysfunction.