Inclusion Criteria:  Specimen collected/handled prior to enrollment in accordance with site policies and procedures. Specimen with adequate volume (1 mL) to complete protocol tests. Specimen is leftover PB and BM from routine flow cytometry laboratory testing for having or suspected of having acute leukemia disorders (i.e. AML, BCP-ALL, ALAL, etc.), myelodysplastic syndrome (MDS), other hematological, or non-hematological disorders. Specimen from newly diagnosed or relapsed subject. Only one specimen type (PB or BM) shall be enrolled per given subject. Specimen is stored at room temperature, upon receipt by the site. Specimens are collected in EDTA (K2 or K3) or heparin (sodium or lithium). Age of specimen (BCP ALL T1: time of collection to start of first pre-wash; ALOT, AML T1-T4: time of collection to start of staining): ≤ 24 hours. Specimens are from subjects irrespective of race, gender, and ethnicity  Exclusion Criteria:  Specimen is from healthy subject. Specimen from subject <3 years of age. Specimen is from subject undergoing any treatment for any form of leukemia. Specimen is from subject with minimal residual disease (MRD) as determined by the site. Specimen is from subject suspected of plasma cell disorders. Visibly clotted specimen. Visibly hemolyzed specimen. Frozen specimen. Refrigerated specimen. Fixed specimen.