Inclusion Criteria:  Subjects must be able and willing to provide written informed consent and comply with the requirements of the study protocol; In good general health, based on answers provided during the screening visit; Subjects must be able to read and understand English; Caucasian female; Aged 18-30 years and ≥ 60 years;  Skin Types (Fitzpatrick Skin Phototypes I-III);  Smoking history is self-report. Have very thin to moderately thick lips (Lip Fullness Grading Scale [LFGS] scores 0-2).  Exclusion Criteria:  Participation in another investigational drug or device clinical trial in the past 30 days; Are pregnant or lactating; Intake of hormone replacement therapy (HRT) in the past 6 months; Have a history of drug or alcohol abuse or have reported habitual alcohol intake greater than 2 standard drinks per day [e.g., 2 beers, 2 glasses of wine, or 2 mixed drinks]; Presence of eczema, psoriasis, or any other skin disease on the lips or perioral skin; Have birth marks, tattoos, scars, or any other disfiguration of the skin in the skin area of interest; Use of any anti-aging skin care products containing retinoic acid, retinol, or other retinoids (e.g. tazarotene, adapalene) or estrogen on the skin area of interest in the past 6 months; Use of any prescription topical medication, such as corticosteroids or hydroquinone on the skin area of interest in the past 6 months; Have a history of photodynamic therapy treatment or any skin rejuvenation procedure on the skin area of interest; History of blood-clotting abnormality; History of keloid formation or hypertrophic scarring; Clinically significant abnormal findings or conditions which might, in the opinion of the Investigator, interfere with study evaluations or pose a risk to subject safety during the study; Exhibits any clinical conditions or takes any medication which in the opinion of the investigator may interfere with the study or pose a risk to subject safety during the study; Is not able to follow study protocol; Have permanent lip implant, and lip enhancement or laser therapy performed within the preceding 12 months; Known history of allergy or sensitivity to glycerol, Tegaderm, lidocaine, hyaluronic acid dermal fillers or materials with gram-positive bacterial proteins.