Inclusion Criteria:  Unilateral involvement; Signs and symptoms of degenerative pathology of the knee cartilage; Radiographic or MRI signs of degenerative pathology of the knee cartilage (Kellgren-Lawrence 1-4 grades); Ability and consent of patients to actively participate in clinical follow-up; Signature of informed consent  Exclusion Criteria:  Patients undergoing knee surgery within the previous 12 months; Patients with malignant neoplasms; Patients with rheumatic diseases; Patients with diabetes; Patients with hematologic diseases (coagulopathies); Patients with metabolic disorders of the thyroid gland; Patients abusing alcoholic beverages, drugs or medications Body Mass Index > 35