Inclusion Criteria:  Present with predominant low back pain and symptoms of DDD of the lumbar region of at least 6 months duration. Failure to have their symptoms resolve or reduce following 12 weeks conservative care (pain medication and/or physical therapy). Male or female patients aged 22 to 80 years, inclusive. Presence of DDD on magnetic resonance imaging (MRI) scan with global disc degeneration. Modified Pfirrmann grades 5 to 8 as characterized by MRI. The presence of one or two symptomatic discs exhibiting degeneration contained within a competent outer annulus as determined by MRI imaging and provocative discography and/or anaesthetic discography at L1-L2, L2-L3, L3-L4, L4-L5, and L5-S1. Patients presenting with a pain level of ≥ 4 out of 10 on the NRS scale and an Oswestry Disability Index (ODI) score of ≥ 30. Patients who are legally competent and able to understand the nature, scope and aim of the clinical investigation. Signed an informed subject consent form in a language in which they are fluent.  Exclusion Criteria:  History of or current systemic or local infection Annular tear or defect that shows free contrast extravasation into the epidural space during or after discography Presence of disc herniation that accounts for the majority of the patient's symptoms. Subjects with Modic type 3 changes Subjects with trans-endplate disc herniations or Schmorl's nodes Neurogenic claudication due to spinal stenosis Previous back surgery at the target level of the lumbar spine Evidence of severe compression of cauda equina Spinal segmental instability (spondylolysis or spondylolisthesis: Grade >1), spinal canal stenosis, isthmus pathology, scoliosis [Cobb angle >10 at the incident level] and other deformity conditions that may compromise the study Subjects with arachnoiditis Subjects who are prisoners of wards or courts Subjects involved in active litigation including worker's compensation cases Subjects with low back pain of non-spinal or unknown etiology Subjects with severe osteoporosis or metabolic bone disease Subjects who have a history of or are current abusers of alcohol or drugs (using definition criteria from the Diagnostic and Statistical Manual of Mental Disorders (DSM-V)) If female, patients who are pregnant or are trying to become pregnant during the course of the trial. (due to risks of additional radiation exposures). Failure to understand informed consent or participation in any other clinical study. Body Mass index (BMI) greater than 40