Inclusion Criteria:  Patients with fabry disease-associated phenotypes in infancy, childhood and adolescence: pain in the hands and feet, angiokeratomas, hypohidrosis, corneal whorls, unexplained renal failure, unexplained hypertrophic myocardiopathy and unexplained early onset stroke.  Exclusion Criteria:  Patient's parent(s) or legal guardian(s) are unable to understand the nature, scope, and possible consequences of the screening.