Inclusion Criteria:  Newly diagnosed patients with Hodgkin's Lymphoma who have not yet received treatment Ages over 15 years old Signed informed consent before registration in study  Exclusion Criteria:  Patients who have already received treatment Patients with a previous history of malignancy Patients with autoimmune diseases Patients with primary immunodeficiency AIDS patients Patients with acute or chronic infections Patients treated with drugs that affect the result of the analysis (Corticosteroids, Immunosuppressants, Li)