Inclusion Criteria:  This will include children and adolescents who fulfill the 2012 Systemic Lupus International Collaborating Clinics (SLICC)(10) classification criteria of SLE.  Inclusion Criteria:  Age younger than 18 years. Active SLE with and without renal affection Patients with biopsy proven LN according to ISN/RPS classification criteria of Lupus nephritis.  Exclusion Criteria:  -Patients in remission.