Inclusion Criteria:  18-65 years old; meet the 2-3 grade dry eye diagnosis: 1) At least one eye has one or more ocular discomfort symptoms and OSDI score ≥23; 2) At least one eye meets one of the following two: 2 mm/5min≤Schirmer I test (no anesthesia) <10 mm/5min; BUT≤10s. 3) Corneal spotting but no extensive erosion.  Exclusion Criteria:  Contact lens wearers; Allergies to the study drug; Active eye infections; history of serious systemic diseases; Pregnancy or breastfeeding; Receiving or starting other treatments that may interfere with the interpretation of the results; Participating any other clinical trials within 3 months; Previous eye surgery, including laser treatment and refractive surgery; Need or have undergone punctal embolization or nasolacrimal duct obstruction; KCS secondary to the destruction of conjunctival goblet cells (such as vitamin A deficiency) ; Scar formation (such as cicatricial pemphigus, alkali burn, trachoma or radiation).