Inclusion criteria for cases:  Adult men and women Well characterized Fabry disease in terms of i. alpha-Gal A enzyme activity, ii. mutation in GLA gene, and iii. disease manifestations Followed at one of the 3 centers for patients with Fabry disease in Sweden (Karolinska in Stockholm, Sahlgrenska in Gothenburg, Akademiska in Uppsala)  Signed informed consent prior to sample collection is mandatory for inclusion to the study.  Inclusion criteria for controls:  Adult men and women Followed/treated at the endocrinology or nephrology in- or out-patient clinic at Sahlgrenska University Hospital in Gothenburg Matched for age, sex, estimated Glomerular filtration rate (eGFR) with the cases with Fabry disease  Exclusion criteria for controls:  Fabry disease Liver disease with elevated transaminases Ongoing infection