Inclusion Criteria:  Patients with biopsy-proven lupus nephritis who experienced an episode of Asymptomatic Serological Flare (ASF) as defined by:  Increase in anti-dsDNA to >100 IU/mL, with or without drop in serum complement levels OR  Increase in anti-dsDNA to higher than the normal range and more than two times of the preceding value, with or without drop in serum complement levels  AND  Absence of renal or systemic manifestation of SLE.  Exclusion Criteria:  Patients who cannot provide informed consent. Patients whom the clinicians opined to have excessively high risk of infection or malignancy. Patients who are pregnant or lactating.