Inclusion Criteria:  Age ≥ 18, both male and female; Patients with primary pancreatic tumor diagnosed by histology, cytology or imaging; Clinical or pathological staging is locally advanced or metastatic pancreatic tumor (newly diagnosed or after surgery and other treatments); You can accept or have not received surgery, chemotherapy, radiotherapy, local treatment or traditional Chinese medicine for tumors; The subject voluntarily joined the study and signed an informed consent form voluntarily.  Exclusion Criteria:  1. Pancreatic tumors are evaluated as metastatic lesions, not primary tumors of the pancreas.