Inclusion Criteria:  Poor Ovarian Response according to Bologna Criteria (fulfilling 2 out of 3 of the following):  Age ≥ 40 years AMH < 1.1 ng/ml OR AFC < 7  ≤ 3 oocytes with a conventional stimulation protocol  Discontinuation of any complementary/adjuvant treatment including hormone replacement, acupuncture, and botanotherapy, for at least three months prior to recruitment. Willing to comply with study requirements  Exclusion Criteria:  Any pathological disorder related to reproductive system anatomy Cycle irregularities Amenorrhea Endometriosis Adenomyosis Fibroids and adhesions Infections in reproductive system Current or previous diagnosis of cancer in reproductive system History of familiar cancer in reproductive system Severe male factor infertility Prior referral for PGT -Ovarian inaccessibility -Endocrinological disorders (Hypothalamus- Pituitary disorders, thyroid dysfunction, diabetes mellitus, metabolic syndrome) BMI>30 kg/m2 or BMI<18.5 kg/m2 Systematic autoimmune disorders