Inclusion criteria:  Subjects aged ≥18. Body temperature < 37.3 ° C confirmed by clinical examination before enrollment . Subjects who meet the diagnostic criteria for HIV infection and AIDS. Female subjects of childbearing age declare that they are not pregnant, have no birth plan in the first 6 months after enrollment, and have taken effective contraceptive measures within 2 weeks before enrollment, and all the above statements are signed and confirmed; For those who are not known to be pregnant, a negative urine pregnancy test is required to confirm that they are not pregnant. Able and willing to complete the entire study plan during the study follow-up period. Have the ability to understand the study procedures, voluntarily sign informed consent, and comply with the requirements of the clinical study protocol.  Exclusion criteria for the first dose:  Subjects were previously confirmed cases of COVID-19 or asymptomatic infected persons. Subjects have history of vaccination against COVID-19. Being allergic to any component of vaccines (including excipients) . Having uncontrolled epilepsy and other progressive neurological disorders and a history of Guillain-Barre syndrome. Pregnant and lactating women. Subjects are suffering from an acute illness; Or thrombocytopenia patients with platelet count < 20×10^9/L within three days before inoculation, that is, patients at high risk of spontaneous bleeding. Acute HIV infection and opportunistic infection. Subjects with co-opportunistic infections who did not receive antiviral therapy. Subjects with CD4+ count less than 50/ul who have not received antiviral therapy. HIV-infected subjects undergoing treatment with severe drug interactions and overlapping toxicity (kidney damage, liver damage, hematological problems, etc.). Patients with malignant tumors are undergoing chemotherapy and radiotherapy before and after surgery. Other subjects whose physical conditions, as determined by the investigator, are not suitable for inclusion in clinical studies.  Exclusion criteria for the second dose:  Subjects who had vaccine-related adverse reactions after the first dose. Having high fever (axillary temperature ≥39.0℃) for three days after the first dose of inoculation, or severe allergic reaction. Having any adverse nervous system reaction after the first dose. During the acute onset of a chronic disease, or the recovery of acute complications less than two weeks. Subjects with severe immunodeficiency (CD4+ count less than 50/ul). Acute HIV infection and opportunistic infection. Subjects with co-opportunistic infections who did not receive antiviral therapy. HIV-infected subjects undergoing treatment with severe drug interactions and overlapping toxicity (kidney damage, liver damage, hematological problems, etc.). Other reasons for exclusion considered by the investigator.