Inclusion Criteria:  Subject age ≥ 18 years Subject has been informed of the nature of the study, agrees to participate and has signed a Medical Ethics Committee approved consent form, understands the duration of the study, agrees to attend follow-up visits LVEF >25% Single de-novo target lesion with stenosis ≥ 70% and < 100% or ≥ 50% and < 70% with evidence of ischemia, or FFR ≤ 0.80, or lumen area ≤ 4.0 mm2 (≤ by 6.0mm2 in left main) IVUS or OCT Target vessel RVD ≥ 2.5 mm and ≤4.0 mm Lesion length ≤ 60 mm Lesion site severe calcification: Angiographic radio-opacities prior to contrast involving both sides of arterial wall with total calcium length ≥10 mm, or presence of ≥270° of calcium on at least one cross section by IVUS or OCT or incomplete balloon expansion at 12 atm Target lesion was traversed by a guide wire  Exclusion Criteria:  Failure to successfully cross the target lesion with the guidewire Target lesion in a coronary artery bypass graft In-stent-Restenosis Thrombus in the target vessel Chronic total occlusion in the target vessel ST-elevation myocardial infarction (STEMI) within the last 4 weeks prior to enrollment Stroke within the last 3 months prior to enrollment Decompensated heart failure Life expectancy of less than one year Chronic kidney disease (serum creatinine > 2.5mg/dl) Pregnant or lactating females Receiving dialysis or immunosuppressant therapy Platelet Count < 100.000mm3 or > 600.000mm3 Significant gastrointestinal bleeding or any coagulopathy that would contraindicate the use of antiplatelet therapy Known allergies or sensitivity to heparin, aspirin, other anticoagulant/antiplatelet therapies or contrast media that cannot be adequately pre-treated prior to index procedure Surgical procedure within the last 30 days prior to enrollment