Inclusion Criteria:  Male or female patients ≥18 years of age Radiologically (MRI) confirmed diagnosis degenerative disc disease of the lumbar spine and/or lumbar disc herniation Unresponsive to conservative/non-operative treatment for >3 months Psychosocial, mental and physical ability to understand and to adhere to this protocol, especially adhering to the visit schedule follow-ups, and observe treatment plan Signed and dated informed consent document prior to any study-related procedures indicating that the patient has been informed of all pertinent aspects of the trial study-related procedures  Exclusion Criteria:  Pregnant or breastfeeding patients Active malignancy Active chronic or acute infection Autoimmune disorder that impacts the lumbar spine (Ankylosing spondylitis, lupus eg.) Acute Episode or major mental illness Major cognitive impairment causing to inability to understand informed consent