Inclusion Criteria:  Adult patients (≥18 years) Admitted to a participating inpatient palliative care unit Agitated delirium: (a) Richmond Agitation-Sedation Scale for palliative care patients (RASS-PAL) score of +2 or greater and (b) Confusion Assessment Method (CAM) positive status and (c) Without a known potentially reversible cause (e.g. hypercalcemia, specific medication infection, etc.), or in whom the patient/Substitute Decision Maker (SDM) has requested not to treat the cause.  Exclusion Criteria:  Hemodynamic instability (systolic blood pressure <80mmHg) Bradyarrhythmia (heart rate < 60) at baseline