Inclusion Criteria:  Primary open-angle glaucoma patients with cataract in our Ophthalmic Center; Topical use of hypotensive drugs in the treatment of poor or intolerable intraocular pressure control; The patients were aged from 50 to 80 years old, regardless of gender; Class operation and phacoemulsification were performed; Patients are able and willing to comply with the research guidance and may complete all visits required by the research; Informed consent has been signed.  Exclusion Criteria:  Allergic to any perioperative medication in this study; History of ocular trauma; Any previous intraocular surgery; Angle of the chamber was narrow by angle microscopy (Schaffer grade III and below); Patients diagnosed as secondary glaucoma; Optic atrophy caused by other reasons; The serious complications such as posterior capsule rupture and choroidal hemorrhage occurred during the operation; Serious complications of eyes occurred after operation; The patient's history indicated that he had severe dysfunction of heart, lung, liver and kidney; Women in pregnancy, lactation or planned pregnancy; The researchers believe that the patient's condition may put the patient at significant risk, and may confuse the research results.