Inclusion Criteria:  Male or Female, age 18-79 Obese: BMI > 30 m/kg2 Hypertensive: blood pressure >130/80 Elevated insulin resistance (HOMA-IR > 2.5) Waist circ: >102 cm (men) and >88 cm (women) Fasting glucose < 126 mg/dL Fasting triglycerides < 250 mg/dL HbA1c < 6.5% Willing to visit research lab (Fairway CTSU) Willing to undergo a blood draw Able to provide written informed consent  Exclusion Criteria:  Current use of clonidine or beta-blockers Current smoker or History of smoking in the past 3 months. Hyperlipidemia: Fasting triglycerides > 250 mg/dL Currently taking hypertension medication History of heart disease (e.g., myocardial infarction, stent, byass, heart attack, stroke, heart failure, valvular heart disease, cardiomyopathy) History of neurological disorders History of transplant Actively participating in other studies, except for a registry study.