Inclusion Criteria:  Adult patients over 20 years old with ASA class I-III Scheduled total mastectomy and deep inferior epigastric artery perforator flap breast reconstruction  Exclusion Criteria:  emergency surgery Bilateral deep inferior epigastric artery perforator flap breast reconstruction patients unable to make their own decisions, illiterate, foreigners Allergy / hypersensitivity to sevoflurane or propofol 5, Current or past history or thrombosis / thromboembolism  6. patients who are taking oral contraceptives 7. Patients with renal insufficiency (eGFR 60 ml / min / 1.73 m 2 or less) 8. Patients receiving anticoagulants 9. pregnant and lactating women 10. Patients with history of psychiatric disease or neurological disease