Inclusion Criteria:  Polypharmacy (i.e. use of ≥ 5 medications for longer than six months) ≥ 2 hospitalizations, day clinic admissions and/or individual ER admissions in the last 12 months Charlson Comorbidity Index (CCI) of ≥ 5 (unadjusted for age) Written informed consent to participate  Exclusion Criteria:  Unable to complete questionnaire or interview in Dutch Less than 6 months anticipated life expectancy Serious cognitive impairment (MMSE score < 16)