Inclusion Criteria:  Males and females age 18-70 years End Stage Renal Disease (ESRD) on dialysis Patient listed and active for a deceased donor kidney transplant and have not received compatible donor offer for ≥3 year. Calculated PRA ≥ 99% Positive CMV serology Positive EBV serology Current vaccination for more than one month for diphtheria, tetanus, poliomyelitis, influenza, pneumococcus, meningococcus, herpes zoster and SARS CoV-2. Patient affiliated to social security insurance or beneficiary of social security insurance  Exclusion Criteria:  Inability or unwillingness of a participant to give written informed consent or comply with study protocol  Known active current or history of recurrent bacterial, viral, fungal, mycobacterial or other infections (including HIV, hepatitis B, hepatitis C, zoster) Patient with positive hepatitis core antigen and/or positive hepatitis B surface antigen Serious uncontrolled concomitant major organ disease Any infection requiring hospitalization and intravenous antibiotics within 4 weeks of screening or Per os antibiotics within 2 weeks Primary or secondary immunodeficiency History of active tuberculosis (TB) (even if treated) or untreated latent TB Malignancy within the last 5 years except documented and treated basal and squamous cell cancer of the skin Alcohol, drug or chemical abuse within 1 year Difficult peripheral venous access Negative EBV serology Negative CMV serology Neutropenia (ANC <1000/uL) or thrombocytopenia (platelet count <100,000/uL) within 4 weeks prior to study entry Patient previously treated with investigational products (belatacept, daratumumab) Severe allergic or anaphylactic reactions to human, humanized or murine monoclonal antibodies Hypersensitivity to any active substance or component of the investigational medicinal products Any contra-indication to premedication drugs (paracetamol, dexchlorpheniramine, cetirizine, dexamethasone, montelukast) or post-medication drugs (corticosteroids, bronchodilators, valaciclovir) Immunization with live vaccine within 2 months of study entry Dry body weight ≥75kg. Pregnancy or lactation Females with childbearing status, defined as a premenopausal female capable of becoming pregnant, and not using an effective form of birth control. Effective birth control methods include oral, implant or patch hormone contraception; intrauterine device; abstinence and outercourse; tubal ligation; vasectomy. Participant involved in another interventional clinical study Person deprived of liberty by judicial order Person under guardianship or curatorship