Inclusion Criteria:  Male or Female patients aged ≥ 22 Severe necrotizing pancreatitis with abdominal compartment syndrome or severe sepsis requiring decompressive laparotomy and/or pancreatic debridement Patients that require open abdomen at the conclusion of their index operation  Exclusion Criteria:  Female patients who are pregnant or lactating If in the opinion of the treating physician a patient should not participate in this study.