Inclusion Criteria:  Is scheduled to undergo an open 1-3 level lumbar laminectomy with or without fixation under general anesthesia. Females are eligible only if not pregnant, not lactating, not planning to become pregnant during the study.  Exclusion Criteria:  Has a contraindication of a known or suspectied history of hypersensitivity or clinically significant idiosyncratic reaction to required study medications. Has a history of severe allergic reaction due to aspirin or other NSAIDs, or known history of severe gastrointestinal adverse reactions associated with NSAID use. Has functioning intrathecal drug pump or spinal cord stimulator. Has a history of spinal nerve ablation within 6 months of Screening (Part B only). Opioid use for most days within the last 3 months. Has initiated treatment with selective serotonin reuptake inhibitors (SSRIs), selective norepinephrine reuptake inhibitors (SNRIs), gabapentin, pregabalin, or duloxetine within 1 month prior to the scheduled surgery. Received an investigational product or device in a clinical trial within 30 days or within 5 elimination half-lives. Has a history of clinically significant cardiac abnormality, coronary artery bypass graft surgery within 12 months, or suspected coagulopathy or uncontrolled anticoagulation. Has loss of sensation in lower extremities or peripheral neuropathy that interferes with balance or walking. Is currently undergoing treatment for hepatitis B, hepatitis C, or HIV. Has undergone 3 or more surgeries within 12 months. Has a known history of glucose-6-phosphate dehydrogenase deficiency. Has History of liver cirrhosis, having an aspartate aminotransferase >3 × the upper limit of normal (ULN), or having an alanine aminotransferase >3 × ULN.