Inclusion Criteria:  Randomized controlled trials Soy protein (Isolated soy protein and non-isolated soy protein) intervention Non-soy protein containing comparator Intervention duration ≥ 3 weeks Data for at least 1 outcome  Exclusion Criteria:  Non-human studies Observational studies Acute single-bolus feeding studies Participants <18 years of age Interventions of soy derivatives or extracts (i.e. soy oil, sterols, etc) No quantification of soy protein in intervention Multimodal interventions Lack of a suitable comparator (i.e. a comparator arm that contains soy protein) Intervention duration < 3 weeks No viable outcome data