Inclusion Criteria:  Clinical indications for HSCT in SCN: clinical diagnosis of SCN with (1) no adequate response to G-CST therapy or (2) with malignant transformation or (3) unfavorable mutations of known SCN genes GATA2 deficiency SCN patients age at HSCT 18 months - 21 years GATA2 deficiency patients age at HSCT more than 10 years Signed informed consent to participate in the study Presence of HLA-matched unrelated or HLA-mismatched related donor  Exclusion Criteria:  Presence of HLA matched related donor in absence of pathologic SCN gene mutation Inability to perform TCRab/CD19 graft depletion Contraindications for HSCT due to patients somatic condition