Inclusion Criteria:  People who live in plain areas all year round and have not been to an altitude of 1500 meters or more in the past 30 days; Sign the informed consent form voluntarily.  Exclusion Criteria:  Chronic physical or mental diseases, including hypertension, diabetes, coronary heart disease, cerebrovascular disease, chronic obstructive pulmonary disease, migraine, anxiety, depression, insomnia, etc.; The female is pregnant or in the period of preparing for pregnancy or breast-feeding; Have a history of smoking; Have a history of thrombosis in the upper limbs; Severe damage to local soft tissues of upper limbs, fractures, etc.; Allergic to sulfa; Are taking one or more drugs; Past laboratory tests suggest hypokalemia, hyponatremia, or liver and kidney damage; Patients unsuitable for enrollment in the clinical trial according to investigators decision making.