Inclusion Criteria:  ASA I-II Aged 18-70 years elective laparoscopic cholecystectomy surgery general anesthesia  Exclusion Criteria:  Morbidly obese patients alcohol or drug addiction chronic obstructive pulmonary disease coronary artery disease congestive heart failure significant anemia liver or kidney disease allergy to propofol or halogenated drugs respiratory system pathology, hypotension hypovolemia and patients with a systemic disease patients using drugs that may affect the oxidation system patients who are converted to open surgery intraoperatively and develop complications