Inclusion Criteria:  Patients diagnosed with an infectious disease or Sepsis patients meeting the diagnostic criteria for sepsis 3.0 (determined by two doctors with senior professional titles) Older than 16 years and younger than 60 years Agree to cooperate with the investigation and sign the informed consent  Exclusion Criteria:  The infection was preexisting with clinically diagnosed organ insufficiency or failure Hematological disorders predate infection Sepsis is preceded by a serious infectious disease Long-term use of immunosuppressant or immunodeficiency patients. A pregnant woman