Inclusion Criteria:  Age 40-80 years old, both male and female; Patients with primary Parkinson's disease who meet the 2015 MDS clinical diagnostic criteria; PD with modified Hoehn-Yahr stage 1-3 and MDS-UPDRS II+III score ≥ 14 and no significant off periods or off periods ≤ 1.5 hours per day (excluding morning motor inability); Pre-enrollment therapeutic medications included Levodopa and Benserazide Hydrochloride Tablets, and all Parkinson's disease medications were unadjusted and motor symptoms were stable for 28 days prior to enrollment; No probiotic or/and prebiotic (including lactulose) and antibiotic therapy for 60 days prior to enrollment, and if so, a 60-day washout period; Understand and agree to follow the study protocol, agree to be enrolled and sign the informed consent form.  Exclusion Criteria:  Parkinson's superimposed syndrome and secondary Parkinson's syndrome, such as multiple system atrophy, progressive supranuclear palsy, etc.； Taking any probiotic or prebiotic (including lactulose) within 60 days prior to enrollment; having inflammation at any site and using any antibiotic within 60 days prior to enrollment; or having blood leukocytes above the upper limit of normal at screening； Combined endocrine disorders, such as history of diabetes or fasting glucose ≥ 7.8 mmol/L, hyper- or hypothyroidism, adrenal tumors, abnormal pituitary function, etc.； Comorbid other neurological disorders, such as cognitive impairment, Mini-Mental State Examination（MMSE） scale score <24; severe anxiety states and/or severe depressive states (Hamilton Depression Inventory-17 item score >17, Hamilton Anxiety Scale score ≥14, or being treated with antidepressant anxiety medication); malignancy, spinal cord lesions, epilepsy, autonomic disorders (urinary retention, urinary incontinence, or upright hypotension , blood pressure drop ≥30/15 mmHg at any time point within 5 minutes of uprightness), etc.; new cerebrovascular disease or sequelae of severe cerebrovascular disease within 6 months, which affects the assessment； Gastrointestinal tumors, history of inflammatory bowel disease, other acute and chronic inflammation of the gastrointestinal tract (including acute attacks of cholecystitis) within 3 months； History of gastrointestinal surgery (excluding endoscopic resection of gastrointestinal benign polyps, appendicitis resection) or constipation caused by surgery； History of anal fissure, perianal abscess, irreversible anal prolapse, pelvic trauma； Severe cardiovascular disease (such as congestive heart failure with a heart function classification of Ⅲ-Ⅳ by the American Heart Association, a history of myocardial infarction within 6 months, etc.); Severe liver and kidney dysfunction with glutamate-pyruvate transaminase, aspartate transaminase and total bilirubin 1.5 times higher than the upper limit of normal; serum creatinine 1.5 times higher than the upper limit of normal; Pregnant and lactating women or women of childbearing age (40-60 years) who are human chorionic gonadotropin (HCG)-positive; Known allergy to test drugs or related products; People with a history of drug abuse or alcohol dependence; Those who have participated in other clinical trials within 3 months prior to enrollment; Refusal to enroll and inability to cooperate with the investigator; patients judged by the investigator to be unsuitable for enrollment.