Inclusion Criteria:  Patient with Parkinson's disease confirmed with UKPDSBB and MDS clinical criteria. who signed the informed consent to follow the study protocol. Age at onset of PD: 45-60 years. Age at enrollment: 45-65 years Disease of 2 to 8 years of evolution Without uncontrolled chronic degenerative disease (High blood pressure, AF, dyslipidemia). Without uncontrolled diabetes mellitus With a fixed treatment during the last 3 months and throughout the study. A patient who does not suffer from another neurodegenerative disease. No symptomatic brain injury. A patient who can lie on his back for at least 2 hours in the OFF state of levodopa.  Exclusion Criteria:  Patients unable to give their informed consent Subjects who are not able to fill out a questionnaire or cooperate during the study Diabetic people or with another uncontrolled chronic disease or with brain injury.