Inclusion Criteria:  Parent or caregiver at least 18 years of age, with a female child, age 2 or older, diagnosed with Rett syndrome confirmed by a disease-causing MECP2 genetic mutation. Fluency in the English language Currently lives with the child with Rett syndrome Ability and willingness to participate in all study activities. Access to a telephone and/or access to a device with internet access that is capable of supporting electronic survey completion  Exclusion Criteria:  Parent or caregiver with clinically significant condition or situation that makes them not be suitable for the study, in the opinion of research staff. Parent or caregiver of a child with Rett syndrome who also has another diagnosis in addition to Rett syndrome.