Inclusion Criteria:  Pathologically confirmed GIST. The tumors can be resected, unresectable, recurrent or metastatic and the patients had ever received, are receiving or will receive systemic treatment (adjuvant, neoadjuvant or salvage TKI or other targeted agents) The tumors were tested for wild type c-KIT and PDGFRA. There are archived tumor samples available or the patients agree to do tumor biopsy for oncopanel test if there is no tumor sample or not enough tumor sample available. The patients who are systemic treatment naïve or have received prior systemic treatment are all eligible. Age - the legal age. Life expectancy greater than 6 months Capable of understanding and complying with the protocol requirements and signed informed consent.  Exclusion Criteria:  Patients will be excluded from the study if they meet any of the following criteria:  Inability and unwillingness to give informed consent Patients do not agree to provide archived tumor samples and blood samples or they do not agree to do tumor biopsy when archived tumor samples are not available. Patients refused for collection of clinical data and follow up. Mental status is not fit for further treatment or data collection.