Inclusion Criteria:  A cohort of patients admitted to the Department of Emergency Neurology at Peking University Third Hospital on January 1, 2017 and admitted on September 30, 2019, who were diagnosed with acute ischemic stroke and underwent intravenous thrombolysis.  Exclusion Criteria:  Patients who underwent intravenous thrombolysis but were confirmed to be apoplexy like by imaging and other clinical examinations; Incomplete craniocerebral MRI examination; Bridging endovascular therapy; The previous application of Yangxuenao granules or other drugs with similar effects;