Inclusion Criteria:  high risk acute B cell lymphoblastic leukemia with the indications for allogeneic transplantation; Have matched sibling donors, ≥8/10 HLA matched unrelated donors or haploidentical donors All patients should aged 12 to 65 years; Liver function: ALT and AST≤2.5 times the upper limit of normal , bilirubin≤2 times the upper limit of normal; Renal function: creatinine ≤the upper limit of normal; Patients without any uncontrolled infections , without organ dysfunction or without severe mental illness; Eastern Cooperative Oncology Group (ECOG) performance status ≤2; Have signed informed consent.  Exclusion Criteria:  pregnant women; Patients with mental illness or other states unable to comply with the protocol; ALL patients with Ph positive;