Inclusion Criteria:  Patient who completed the CL2-95014-002 study Patient currently receiving clinical benefit from previous treatment with S95014 as per investigator's judgment Signed informed consent and assent, when appropriate Highly effective contraception method  Non-inclusion Criteria:  Unlikely to cooperate in the study Pregnant and lactating women Participant already enrolled in the study (informed consent signed) Prior surgery or bone marrow transplant related to the studied disease History of sensitivity to polyethylene glycol (PEG) or PEG-based drugs Psychiatric illness/social situation that would limit compliance with study requirements Group "E" and "T-HR" patients according to ALL-MB 2015 protocol classification Major safety issue due to previous S95014 administration (e.g. non recovery of safety parameters, serious hypersensitivity, serious pancreatitis, serious haemorrhage, serious thromboembolic event) Significant laboratory abnormality or uncontrolled intercurrent illness (e.g. life-threatening acute tumor lysis syndrome, symptomatic congestive heart failure, cardiac arrhythmia, severe or uncontrolled active acute infection) likely to jeopardize the patients' safety or to interfere with the conduct of the study, in the investigator's opinion