INCLUSION CRITERIA  Histologically proven prostate adenocarcinoma; Intermediate and High risk disease, as per the NCCN definition; N0M0 at staging with standard techniques (Bone Scan and Abdominal CT) or (preferably) Choline or PSMA PET-CT; ECOG performance status between 0 and 2; Life expectancy of > 5 years, in the opinion of the investigator; IPSS score must be ≤ 19 (alpha blockers allowed);  EXCLUSION CRITERIA:  ≥T3b disease according to the 8th AJCC classification; PSA>20 ng/ml at any time point; Previous local treatment of the prostate with surgery (radical prostatectomy or cryotherapy); Previous radiotherapy to the pelvis; Previous invasive malignancy unless disease free for a minimum of 5 years; Active Crohn's Disease or Ulcerative Colitis;