Inclusion Criteria: all population  No history of respiratory diseases (childhood asthma, respiratory allergies, exercise-induced asthma or dyspnea) Willing to participate and able to sign an informed consent form (ICF) Being affiliated with the French Social Security  Inclusion Criteria:Patients with diabetes  type 1 diabetes mellitus or type 2 diabetes mellitus (ADA definition) Age : 18 to 75 years stable diabetes treatment for more than 3 months no diabetic retinopathy no diabetic neuropathy no cardiovascular diseases no contra-indication for coronary computed tomography angiography or myocardial perfusion scintigraphy.  Inclusion Criteria: Healthy volunteers  Age : 18 ; 40 years No diabetes No persistant drug use > 3 months except contraception Body mass index : [18,5 - 29,9] kg/m2  Non-inclusion criteria : all population  Active smokers Pregnant or breastfeeding women, women of childbearing age without effective contraception Known allergies to the patch. Skin lesions at the sensor site that may interfere with sensor placement or accuracy Major cardiovascular complications within the past 3 months Decompensated congestive heart failure Chronic respiratory failure Chronic renal failure Resting ambient air O2 saturation ≤95%. Treatment with systemic corticosteroids Severe hypertension (≥180 mmHg systolic pressure or ≥ 100 mmHg diastolic pressure) Any concomitant disease or condition that the investigator believes may compromise patient safety or affect the conduct of the study Anemia (Hb<12g/dl) History of severe mountain sickness Concurrent participation in another clinical research study, Persons benefiting from enhanced protection  Non-inclusion criteria: Patients with diabetes  Absolute contraindications to physical activity (HAS definitin) : Pulmonary arterial hypertension (> 60 mm Hg) Presence of intra-cardiac thrombus Acute pericardial effusion Severe obstructive cardiomyopathy Symptomatic aortic stenosis Recent thrombophlebitis with or without pulmonary embolism