Inclusion Criteria:  Patients with sepsis requiring surgical treatment under general anesthesia should be transferred to ICU with endotracheal intubation for further treatment after surgery 18≤ age ≤85, gender and nationality is not limited Agree to participate in this study and sign the informed consent  Exclusion Criteria:  Declined to participate in this study Patients in pregnancy or with drug allergy in this study Patient had chronic or acute respiratory ailments long-term preoperative continuous ventilatory support or oxygen dependency Patients are now being included in another study In the opinion of the attending physician or researcher, there are other conditions that are not appropriate for the study