Inclusion Criteria:  Patients between 20 and 65 years (+/- 2 years) Patients of the CRCM of Reims University Hospital Patients with at least one CF causing mutation in CFTR gene Patients agreeing to participate in the study (informed consent form) Patients fluent in French Patients affiliated with a social security regimen Healthy donors between 20 and 65 years (+/- 2 years) Healthy donors giving blood at EFS GE, Reims Healthy donors agreeing to participate in the study (informed consent form) Healthy donors fluent in French Healthy donors affiliated with a social security regimen Healthy donors whose characteristics agree with the ALC/PIL/DIR/AJR /FO/606 convention between EFS GE, Reims, and Reims Champagne-Ardenne University  Exclusion Criteria:  Patient having a medical history that may compromise the protocol (psychiatric, medical or pharmacological disorders such as the use of anti-inflammatory drugs, or any compound that may alter or modify the inflammatory reaction in the week preceding the protocol). Pregnant or breastfeeding women Patient with eating disorders (anorexia, bulimia, overeating) Patient protected by law (guardianship, curatorship, hospitalized without their consent and not protected by law, deprived of liberty)