Inclusion Criteria:  Age > 18 years, both sexes, history of sensory and/or motor complaint with progressive course over more 2 months  Exclusion Criteria:  *Patients with systemic diseases (DM, chronic kidney or liver disease, thyroid disease, vitamin B12 deficiency)  Family history of peripheral neuropathy or neurological symptoms suggestive for heredo-familial neurological disorders Patients with infective cause as (HBV, HCV, HIV, leprosy) Toxic and drug induced polyneuropathy (chemotherapeutics, antimicrobial ..