Inclusion Criteria:  Age: 18 years or older Male sex at birth Self-identify as a woman, a transgender woman, or another identity along the male-to-female gender spectrum PrEP naïve PrEP indicated per CDC guidelines (incl. HIV negative) Owns a cell phone or willing to use one in the study Able to understand and speak English or Spanish  Exclusion Criteria:  Unable to provide informed consent due to severe mental or physical illness, cognitive impairment, or substance intoxication at time of visit Has lived in RI for less than three months (as a means to enhance participant retention) Discovery of active suicidal ideation or major mental illness (e.g. untreated psychosis or mania) at the time of interview (these patients will be referred immediately for treatment, but may join the study when this is resolved) Laboratory or clinical findings that would preclude PrEP initiation (e.g. Hepatitis B infection, decreased creatinine clearance)