Inclusion Criteria:  Age 18 ~ 75 years old (including boundary value), male and female; Radical resection of liver cancer and intraoperative ablation of tumors ≤ 2cm were performed 4 ~ 8 weeks before enrollment;  Hepatocellular carcinoma diagnosed by pathology and meeting at least one of the following conditions:  Single tumor with tumor size ≥ 5cm; Pathology showed microvascular invasion (MVI); Satellite foci were found in the specimens; Multiple lesions (≥ 3); AFP ≥ 400 ng / ml one week before operation Preoperative imaging and / or intraoperative or postoperative pathological reports found PVTT type I: tumor thrombus invaded the secondary and above branches of portal vein; No anti-tumor treatment was received before operation; Liver function grade child Pugh a; Physical condition (PS) score of Eastern cancer cooperation group (ECoG) was 0-1; Imaging examination ≥ 4 weeks after operation confirmed that there was no recurrence and metastasis; The estimated survival time shall not be less than 3 months;  With sufficient organ function reserve, the laboratory test values within 14 days before treatment must meet the following standards:  Blood routine examination: Hb≥100 g/L; ANC≥1.5 × 109 /L; PLT≥75 × 109 /L Biochemical examination: ALB ≥28g/L; ALT and AST < 5 × ULN; TBIL ≤2 × ULN; creatinine ≤ 1.5 × ULN or creatinine clearance (CCR) ≥ 50 ml / min The electrolyte is basically normal or normal after treatment; Urinary protein < 2 + or 24-hour urinary protein quantitative test ≤ 1.0 g / L (for patients with urinary protein ≥ 2 +, 24-hour urinary protein quantitative test should be carried out, and they can be selected only when it is ≤ 1.0 g / L); Coagulation function:  international standard ratio (INR) or prothrombin time (PT) ≤ 1.5 × ULN activated partial coagulation time (APTT) ≤ 1.5 × ULN  Patients with HBsAg positive should continue antiviral treatment after operation and take first-line antiviral drugs such as entecavir or tenofovir or propofol tenofovir fumarate; The patients were enrolled voluntarily, could provide written informed consent, and could understand and comply with the trial protocol to follow-up.  Exclusion Criteria:  The pathological diagnosis was fiberboard HCC, sarcomatoid HCC, hepatocellular carcinoma intrahepatic cholangiocarcinoma (HCC-ICC); Positive margin or tumor rupture; Reoperation of recurrent liver cancer; Previous liver transplantation; AFP did not return to normal at 4 weeks and did not return to normal at 6 weeks after operation; Previously received systemic therapy for HCC, including targeted drug therapy such as Sorafenib, Lenvatinib and Regorafenib, or immunotherapy such as anti-PD-1, anti-PD-L1 and anti-CTLA-4, except antiviral therapy; If the patient has previously used traditional Chinese medicine with anti-tumor indications, it must be more than 4 weeks after the completion of treatment and before the medication in this study, and the adverse events caused by treatment have not recovered to ≤ CTCAE level 1; Received other adjuvant therapy (except antiviral therapy), including adjuvant local therapy; There were tumor thrombi in the main portal vein and primary branches, inferior vena cava, hepatic vein or bile duct, lymph node invasion or extrahepatic metastasis before operation; 5 years of suffering from other malignancies, unless the patient has received the possibility of curative treatment and there is no evidence of the disease within 5 years, the time requirement (i.e. 5 years) does not apply to successful basal cell carcinoma, cutaneous squamous cell carcinoma, superficial bladder cancer, cervical carcinoma in situ or other orthotopic cancer. Previous history of severe mental illness; Suffering from diseases affecting the absorption, distribution, metabolism or clearance of the study drug (such as severe vomiting, chronic diarrhea, intestinal obstruction, absorption disorder, etc.); Taking drugs that may prolong QTc and / or induce tip twist transition ventricular tachycardia (TDP) or drugs that affect drug metabolism at the same time; The patient has known or suspected allergy to tyrosine kinase inhibitor (TKI) drugs, or is allergic to the excipients of the study drugs; There are uncontrollable hepatic encephalopathy, hepatorenal syndrome, ascites, pleural effusion or pericardial effusion; Have active bleeding or abnormal coagulation function, have bleeding tendency or are receiving thrombolytic, anticoagulant or antiplatelet therapy; Have a history of gastrointestinal hemorrhage or have a clear tendency of gastrointestinal bleeding in the past 4 weeks (e.g. local active ulcer lesions, fecal occult blood + + or more, gastroscopy should be performed if continuous fecal occult blood +, or other conditions that may cause gastrointestinal bleeding determined by the researcher (e.g. severe gastric fundus / esophageal varices); Gastrointestinal perforation, abdominal fistula or abdominal abscess occurred in the past 6 months; Thrombosis or thromboembolism events occurred in the past 6 months, such as stroke and / or transient ischemic attack, deep vein thrombosis, pulmonary embolism, etc;  Uncontrolled cardiovascular disease judged by the researcher. Including but not limited to the following situations:  acute myocardial infarction in the past 6 months; Severe / unstable angina pectoris or coronary artery bypass grafting; Congestive heart failure (NYHA > 2); Arrhythmias with poor control or requiring pacemaker treatment; Hypertension (systolic blood pressure ≥ 140 mmHg and / or diastolic blood pressure ≥ 90 mmHg) ";  Active infection requiring treatment  Active hepatitis B (HBsAg positive and abnormal liver function): if the HBV-DNA is ≥ 104 copies / ml within 14 days before treatment, the patient shall first undergo antiviral treatment, reduce it to < 104 copies / ml, and then enter the study, continue antiviral treatment and monitor liver function and serum HBV-DNA level; Active hepatitis C (HCV-RNA ≥ 103 copies / ml) with abnormal liver function [ALT or ast > 3 × ULN with TBIL > 2 × ULN or clinical jaundice]); pregnant or lactating women, and female or male patients with fertility are unwilling or unable to take effective contraceptive measures;