Inclusion Criteria:  Patients with an indication for PCI due to acute coronary syndrome All target lesions can be successful treatment of PCI with drug-coated balloon (DCB) Patients who are able to complete the follow-up and compliant to the prescribed medication  Exclusion Criteria:  Under the age of 18 or Older than 80 years old Unable to give informed consent Patient is a woman who is pregnant or nursing (a pregnancy test must be performed within 7 days prior to the index procedure in women of child-bearing potential according to local practice) Known contraindication to medications such as Heparin, antiplatelet drugs, or contrast. Currently participating in another trial and not yet at its primary endpoint Planned elective surgery Concurrent medical condition with a life expectancy of less than 1 years Previous intracranial haemorrhage Need long-term oral anticoagulant therapy Cardiogenic shock Previous stent implantation 6 month In-stent thrombosis Target lesion located in surgical conduit