Inclusion Criteria:  Males or females BMI between 18-23 and 27-35  Exclusion Criteria:  History of acute cardiac event, stroke, or cancer Alcohol or substance abuse within the last 6 months Pregnancy or lactation (or planned pregnancy) No recurrent hospitalizations within the last 6 months Allergy against any of the study treatments (mango or probiotics) Liver or renal dysfunction Hepatitis B or C, HIV Currently smoking more than 1 pack/week History of dizziness/fainting during/after blood draws