Inclusion Criteria:  The subject is capable to understand and willing to provide written informed consent before any study-related activities (study-related activities are any procedures that would not have been performed during normal management of the subject's disease). The subject is at least 18 years of age. The subject has been diagnosed with stage IV PDAC (Pancreatic Ductal Adenocarcinoma) and is amenable to first-line systemic therapy. The subject must have measurable disease that is histologically or cytologically confirmed. The subject has an ECOG (Eastern Cooperative Oncology Group) performance status of 0 or 1. The subject has a primary or metastatic lesion amenable to biopsy and is willing to undergo repeat biopsies, unless a biopsy would not be safe in the opinion of the investigator and in agreement by the sponsor and medical monitor (or designee).  The subject has clinically adequate bone marrow, hepatic, and renal function based on clinical laboratory test values at screening within the following ranges:  Creatinine clearance >30 mL/min calculated by Cockcroft-Gault formula Haemoglobin >90 g/L (blood transfusions during the screening period are not allowed) Absolute neutrophil count >1.5 × 109/L (usage of growth factors, such as G-CSF (Granulocyte Colony-Stimulating Factor), during the screening period is not allowed) Platelets >100 × 109/L Total bilirubin <1.5 × ULN unless due to Gilbert's syndrome AST and ALT ≤3 × ULN (or <5 × ULN for subjects with hepatic metastases) The subject has a QT interval corrected using Fridericia's formula (QTcF) of ≤ 480 milliseconds at screening. Female subjects of childbearing potential (more info can be found in the protocol) and male subjects with female partners of childbearing potential must be willing to adhere to contraceptive requirements as detailed in the protocol, from at least 1 month prior to study entry to at least 4 months after the last dose of study treatment. The subject has suitable venous access for safe drug administration and the study- required drug concentration and pharmacodynamic sampling.  Exclusion Criteria:  Subjects who have received previous radical radiotherapy, chemotherapy, or investigational therapy for the treatment of metastatic disease.  Prior treatment with 5-FU or gemcitabine administered as a radiation sensitiser during and up to 4 weeks after radiation therapy, is allowed; however, if there is lingering toxicity (Grade >1), then the sponsor should be consulted. If a subject received adjuvant or neoadjuvant chemotherapy, tumour recurrence or disease progression must have occurred no sooner than 6 months after completing the last dose. Subjects with uncontrolled brain metastases; however, subjects are allowed if they have been previously treated with surgery, whole-brain radiation, and/or stereotactic radiosurgery and are considered controlled (with ≤10 mg/day of prednisone or equivalent) at the time of receiving the first dose of CAN04. For asymptomatic subjects, screening brain imaging is not required. Subjects with endocrine or acinar pancreatic carcinoma. Subjects with an active severe infection requiring parenteral antibiotics at the time of enrolment or subjects currently receiving oral antibiotics as a continuation of a previous course of parenteral antibiotics. Subjects with peripheral sensory neuropathy Grade ≥2. Subjects with a serious uncontrolled medical disorder that, in the opinion of the investigator or medical monitor, makes it unwise for the subject to participate in the study or that might jeopardise compliance with the protocol. Subjects with psychiatric illness/social circumstances that would limit compliance with study requirements and substantially increase the risk of AEs (Adverse Events) or has compromised ability to provide written informed consent. Subjects with an active second invasive malignancy with the exception of stable prostate cancer on watchful waiting. Subjects with uncontrolled or significant cardiovascular disease defined as NYHA (New York Heart Association) classification III or IV. Subjects with congenital long QT syndrome. Subjects with a history of autoimmune disease requiring systemic immunosuppressive therapy (daily prednisone equivalent doses >10 mg/day). Subjects with known hepatitis B virus surface antigen seropositive or detectable hepatitis C infection viral load. NOTE: Subjects who have positive hepatitis B core antibody or hepatitis B surface antigen antibody can be included but must have an undetectable hepatitis B viral load.  Subjects with a known history of any other relevant congenital or acquired immunodeficiency other than HIV infection. NOTE: Subjects testing positive for HIV are NOT excluded from this study, but HIV- positive subjects must meet the following criteria:  Have CD4+ T-cell (CD4+) counts ≥350 cells/µL. Have not had an opportunistic infection within the past 12 months. Subjects on prophylactic antimicrobials can be included in the study. Should be on established antiretroviral therapy for at least 4 weeks. Have an HIV viral load less than 400 copies/mL prior to enrolment. Subjects who receive a live vaccination, etanercept, or other TNF-α (Tumor Necrosis Factor-alpha) inhibitors during or just prior to (within 28 days of first dose of study treatment) participation in this study. Subjects who have had a hospitalization for bowel obstruction within 12 weeks prior to enrolment. Subjects with a known bleeding disorder or coagulopathy. NOTE: Subjects on stable anticoagulant therapy are allowed at the discretion of the investigator; however, these subjects should be monitored more frequently. Subjects with a known or suspected allergy to any study treatment or related products, including platinum-based chemotherapeutic agents. Female subjects who are pregnant or breastfeeding or trying to become pregnant.