Inclusion Criteria:  Pathologically or radiologically confirmed diagnosis of CGC or GBC With or without prior radiation or chemotherapy All United States of America (USA) and non USA residents No age, gender, or racial restriction Healthy control with no current or history of cancer Healthy controls are USA and non USA residents Healthy controls are matched to the cases in age (5 years), gender, and race Healthy controls are friends and spouses of patients with other than gastro-intestinal (GI) cancers Chronic Liver Disease (CLD) controls with no current or history of cancer CLD controls are USA and non USA residents CLD controls are frequency matched to CGC cases by age (5 years), gender, and race CLD controls are patients are diagnosed with or without liver biopsy (core or fine needle aspiration) CLD controls must not have evidence liver cancer diagnosis by computed tomography (CT) or magnetic resonance imaging (MRI)  Exclusion Criteria:  None