Inclusion Criteria:  Chronic hepatitis B (positive HBsAg for at least 6 months prior to NA therapy start) Patients on-treatment with NAs  Exclusion Criteria:  Treatment with immunosuppressors (including systemic corticosteroids) or anti-neoplastic treatment (including radiation therapy) <=6 months prior to the first dose of study drug or the expectation that such treatment will be needed at any time during the study. History of depression or uncontrolled psychiatric disorders Subjects protected by law or not in a position to give consent