Inclusion Criteria:  Patients who fulfilled the criteria for the NO-ALS study and have completed the study will be proposed inclusion in the NO-ALS extension study protocol. Patients from both arm 1 and arm 2 in the NO-ALS study will be allowed inclusion in the prolongation study  Exclusion Criteria:  Individuals will be excluded if any of the following exclusion criteria apply:  Dementia, FTD or other neurodegenerative disorder interfereing with compliance. Metabolic, neoplastic, or other physically or mentally debilitating disorder. Patients who become tracheostomized as part of the treatment of ALS. Patients with short expected survival at the discretion of the investigator. Such cases cannot be expected to follow protocol procedures. Use of Vit B3 or blue berry extracts outside the study