Inclusion Criteria:  1. A: ≥ 3 times embryo transfer failures，and at least accumulated 4 high-quality embryos were transferred  B: Two times consecutive embryo transfers failures, at least accumulated 4 high-quality embryos were transferred  2. Undergo IVF / ICSI / PGT;  3. Transfer 1-2 D3 cleavage embryos or blastocysts in IVF / ICSI and transfer 1 blastocyst in PGT;  4. 20-38 years old female  5. Sign the informed consent voluntarily.  Exclusion Criteria:  Contraindications for pregnancy or assisted reproductive technology; Chromosome abnormality of husband or wife (except polymorphism); Abnormal gene diseases; Untreated of uterine diseases that affect the uterine cavity morphology (uterine malformation, submucous myoma, adenomyosis, endometriosis and endometriosis etc.); AMH < 1.1ng/ml or AFC < 7; The most thickness of endometrium is less than 7 millimeter; Those who have more than 2 times clinical pregnancy abortion; Patients with serious primary diseases including cardiovascular, cerebrovascular, liver, kidney and hematopoietic system and mental diseases The treatment (such as acupuncture and traditional Chinese Medicine) related to help pregnancy had been carried out in the last 3 months.