Inclusion Criteria:  Age from 45 to 74 years Undergoing elective orthopedic surgery Provide written informed consent to participate in the PoD trial  Exclusion Criteria:  Undergoing emergent/urgent surgery Montreal Cognitive Assessment < 18 points History of mental disorders according ICD-11 Treated with at least one psychotropic drug Patients with neuromuscular disease Inability to undergo preoperative assessment for any reason Previously enrolled in PoD trial