Inclusion Criteria:  Age ≥18 and ≤75 years Witnessed cardiac arrest CPR initiated within 7 min of presumed arrest Cardiac arrest not responding to standard ALS Total CPR time ≤ 40 min at the time of screening for enrollment  Exclusion Criteria:  Traumatic cardiac arrest Known pregnancy Known terminal disease Known Do-Not-Resuscitate (DNR) order Subjects whose femoral arterial access site cannot accommodate an 8 Fr introducer sheath Subjects currently on mechanical circulatory support