Inclusion Criteria:  Participants aged 18 years or older. Both inpatients and outpatients. Healthy volunteers or patients with suspected esophageal disease Able to provide informed consent.  Exclusion Criteria:  known or suspected complex history of gastrointestinal obstruction, stenosis or fistula. dysphagia. known or suspected possibility of active bleeding of digestive tract. Pregnancy or suspected pregnancy.. Patients who have participated in or are participating in other clinical trials within three months. Life-threatening conditions. other circumstances that doctors consider inappropriate for the study.