Inclusion Criteria:  Age ≥ 18 years of age. Have an ECOG Performance Status of ≤ 2. No evidence of distant metastasis on imaging. Histologic or cytologic proven adenocarcinoma of the pancreas. Providing informed consent prior to enrollment in the trial.  Exclusion Criteria:  Failure to obtain additional core needle biopsies for generating PDTs. Females who are pregnant or plan to become pregnant.