Inclusion Criteria:  19 years ≤ age ≤ 80 years Those who are diagnosed as CEAP Classification Class 1 ~ Class 3  Those who have the Venous Duplex ultrasonography result at least one of the following  reflux more than 1 second in Femoral vein or Popliteal vein reflux more that 0.5 second in GSV or SSV or Accessory saphenous vein or perforating vein or calf vein  Those who have completed the washout period as following until the baseline, including the screening period  Analgesic, corticosteroids, anti-inflammatory drugs: at least 2 weeks Those who provide written consent voluntarily to participate in this clinical trial  Exclusion Criteria:  Those who must wear compression stockings Those who have obstruction of the peripheral arteries of the lower extremities Those who have asymptomatic varicose veins Those who have acute deep vein thrombosis Those who have frequent lower extremity pain due to neuropathy Varicose vein surgery patient or prospective person (if surgery was done more than 1 year prior to the time of screening, recruitment is possible) Those who have systemic disease that causes edema or thrombosis Those who have a history of malignant tumors within 5 years prior to the time of screening Those who have severe renal dysfunction at the time of screening (serum creatinine ≥ 2 x upper limit of normal) Those who have severe liver dysfunction at the time of screening (AST or ALT ≥ 3 x upper limit of normal) Those who are required to receive diuretics, analgesics, corticosteroids, anti-inflammatory drugs, or contraindications that may affect the outcome of this clinical trial during the clinical trial period Those who have a history of significant mental illness, alcohol abuse Patients who have an allergy to investigational product or any of its excipients Patients who participated in other clinical trials within 12 weeks prior to the date of screening Pregnant or lactating woman Those who do not agree to use an effective method of contraception Individual considered by the investigator to be ineligible for study participation