Inclusion Criteria:  patients are diagnosed as brain metastases by Xiangya Hospital multidisciplinary team; age from 18 to 65 year-old; patients have been progressed from standard therapy (drug/radiation resistance) KPS more than 70 score; anticipated OS more than 3 months; signed consent form.  Exclusion Criteria:  unable to take TTFields more than 18 hours each day; unable to follow-up till progression; the scalp wound is not well healed, the head skin condition is not good, the skull has a large area defect, or other situations that are not suitable for wearing electrodes pregnant women; last drug within 4 weeks, last radiation within 3 months, take other trials; other heavy diseases like heavy infection; other condition: Such as breastfeeding, installation of cardiac pacemakers, brain stimulators, severe intracranial edema, increased intracranial pressure leading to midline structures exceeding 5 mm, optic nerve head edema, disturbance of consciousness, etc., allergies to conductive coupling agents, gels, etc. blood and biochemical indicators in the following range: A. Liver function impairment: AST or ALT > 3 times the upper limit of normal; B. Total bilirubin> upper limit of normal value; C. Renal impairment: serum creatinine>1.7mg /dL (>150 mol/L); D. Coagulopathy: PT or APTT >1.5 times normal; E. Platelets counts < 100x10^9/L; F. Absolute neutrophils count < 1x10^9/L; G. Hemoglobin < 100g/L; other conditions physicians not suggest to take the trial