Inclusion Criteria:  Healthy males and females ages 18-40 Non-smoking Able to provide informed consent and agree to adhere to all study visits and requirements. Females of childbearing potential must have a negative blood pregnancy test at screening and agree to use one of the accepted contraceptive regimens, or a double method of birth control during the study and at least 30 days after the last dose of study drug. Males who engage in sexual activity that has the risk of pregnancy must agree to use a double barrier method and agree not to donate sperm during the study and for at least 90 days after the last dose of study drug  Exclusion Criteria:  Allergy to study medication Pregnant or breast feeding Received investigational medicine (IMP) within past 30 days VO2 max < 35 mL/kg/min (male), < 30 mL/kg/min (female) at screening Abnormal pulmonary function testing at screening Surgery or hospitalization in past 3 months determined by the PI to be clinically relevant History of ongoing alcohol or substance abuse Known cardiovascular disease, including treated or untreated hypertension Respiratory disease and/or any other significant medical condition, including psychiatric disorders Clinically significant abnormality on ECG per PI discretion Blood donation (excluding plasma donation) of approximately 500 mL within 56 days prior to screening Plasma donation within 7 days prior to screening Treatment with an investigational drug within 30 days or 5 times the half-life (whichever is longer) prior to screening History of smoking Urine screen positive for drugs or positive breathalyzer for alcohol (at screening and Treatment Visit Day 1) History of seizures Previous pneumothorax or pneumomediastinum Hypo/Hyperglycemia Diabetes Regularly taking medications which may alter heart rate, blood pressure or cardiac output Previous history of middle ear equalization problems at discretion of PI