Inclusion Criteria: All of the below must be fulfilled:  Unplanned emergency department admission Age ≥ 18 years  Sepsis defined as  suspected infection by the treating clinician AND blood cultures drawn AND IV antibiotics administered or planned AND An infection related increase of SOFA*-score ≥ 2 from baseline  Expected hospital stay > 24 hours as deemed by treating clinician  Sequential Organ Failure Assessment (SOFA) Score  Further more the patient must fulfill criteria for enrollment in an acute study according to Danish law  Exclusion Criteria: We will exclude patients fulfilling any of following exclusion criteria:  ≥ 500 ml of fluids given prior to randomization Invasively ventilated or vasopressors initiated at the time of screening Known or suspected severe bleeding judged by the treating clinician Known or suspected pregnancy (women aged <45 years will have a pregnancy test performed before enrollment) Prior enrollment in the trial Patients, who the clinician expect not to survive the next 24-hours