Inclusion Criteria:  OL diagnosis should be confirmed by incisional diagnostic biopsy and subsequent histopathological analysis Subjects' age: 18 years or older Lesions' size: 3 cm maximum longitudinal size of the single lesion Lesions's location: oral areas with no surgical risk of damages to important anatomical structures such as nerves, salivary ducts and/or arteries. Ability to understand and to sign a written informed consent document  Exclusion Criteria:  Previous oral cancer Head and neck radiotherapy Subjects under the age of 18 Subjects affected by PVL (proliferative verrucous leukoplakia) High-risk of surgical damages to anatomical structures such as nerves, salivary ducts and/or arteries