Inclusion Criteria:  Male or female participants ≥ 18 years of age; Confirmed diagnosis of a stage 1-3 solid tumor; or Curative surgery or definitive therapy (e.g., chemoradiation, SBRT) planned within 28 days of consent or occurred without any current evidence of radiographical or biochemical recurrence; Able to tolerate venipuncture for blood draws; and Primary diagnosis is not glioma or CNS disease. Both the tumor tissue sample and blood sample pass the quantity and quality parameters to allow for a successful MRD test result