Inclusion Criteria:  With chronic liver disease Age 18-80 years Patients who require a portal pressure measurement at the discretion of the treating physician Voluntarily signed informed consent  Exclusion Criteria:  With serious cardiopulmonary disease or other diseases affect survival With severe renal dysfunction Concomitant portal vein cavernous degeneration or extensive portal vein thrombosis Women who are planning to become pregnant or who are pregnant or breastfeeding The researcher judged that it was not suitable to participate in this study