Inclusion Criteria:  patients aged > or equal to 40 years diagnosis of stage 2, 3 or 4 melanoma treated with an ICI not currently treated with a statin ,and having acceptable imaging quality deemed by the core laboratory  Exclusion Criteria:  inability to provide informed consent unwilling to be followed for serial evaluation contra-indication or intolerance to statins clinically manifest CV disease prognostic factors associated with an expected survival less than 18 months (eg. un-resectable brain metastases) severe liver disease or advanced renal disease (³stage 3b CKD or eGFR <45 ml/min) any other factor that will preclude patients from participating in all study related activities