Inclusion Criteria:  Age: ≥ 18; Ischemic stroke confirmed by head CT or MRI; Patients receiving endovascular treatment; First ever stroke or pre-stroke mRS≤2; signed informed consent.  Exclusion Criteria:  Prestroke mRS≥3; Other serious illness that would confound the clinical outcome at 90 days; Unavailable neuroimaging data; Other unsuitable conditions judged by the investigator