Inclusion Criteria:  Above 18 years of age Sepsis of any background Vasopressor-dependent sepsis for at least 2 hours and vasopressor dose ≥ 0.25 µg / kg / min  Exclusion Criteria:  Pregnancy; Requests for DNR (do not resuscitate) / DNI (do not intubate); Death is considered imminent or inevitable during this hospitalization and the attending physician, patient or substitute decision maker is not committed to active treatment; Patients with acute cerebral vascular event, acute coronary syndrome, active gastrointestinal bleeding, burn or trauma at admission; Patients with known HIV infection; Patients with known glucose-6 phosphate dehydrogenase (G-6PD) deficiency; Patients with septic shock transferred from another ICU or hospital with characteristics of septic shock for> 12 hours; Patients with septic shock characteristics for> 12 hours; Patients with a known history of oxalate nephropathy; Patients with short bowel syndrome or severe known fat malabsorption; Patients with acute beriberi disease; Patients with acute Wernicke's encephalopathy; Patients with known malaria; Patients with known or suspected scurvy; Patients with known or suspected Addison's disease; Patients with known Cushing's disease; Physician expects to prescribe or the patient has previously used (less than 15 days) systemic glucocorticoids for an indication other than septic shock (not including nebulized or inhaled corticosteroids), including the use of glucocorticoids for COVID-19; The patient is receiving treatment for systemic fungal infection or has documented Strongyloides infection at the time of randomization; Patient with known chronic iron overload due to iron storage and other diseases; Patient previously enrolled in this study.