Key Inclusion Criteria:  Forced expiratory volume in 1 second (FEV1) value ≥30% and ≤90% predicted Heterozygous for CF transmembrane conductance regulator gene (CFTR) F508del mutation and a minimal function mutation (F/MF genotypes)  Key Exclusion Criteria:  Clinically significant liver cirrhosis Solid organ or hematological transplantation Non-ambulatory status Lung infection with organisms associated with a more rapid decline in pulmonary status  Other protocol defined Inclusion/Exclusion criteria may apply