Inclusion Criteria:  Subject is between 18 and 80 years of age at the time of surgery Subject is a candidate for a cholecystectomy Subject has a diagnosis of acute cholecystitis and is being admitted through the Emergency Room (ER)  Exclusion Criteria:  A single port (single site or single incision procedure) cholecystectomy will be performed Subject will undergo a concomitant procedure Subject is contraindicated for surgery or a minimally invasive approach Subject has a known bleeding or clotting disorder that is not able to be controlled during surgery Pregnant or suspect pregnant Subject is mentally handicapped or has a psychological disorder or severe systematic illness that would preclude compliance with the study requirements or ability to provide informed consent Subject belonging to other vulnerable population, e.g. prisoner or ward of the state Subject is unable to comply with the follow-up visit schedule Subject is currently participating in another research study