Inclusion Criteria:  Healthy male subjects above 18 years old (including 18 years old). Weight not less than 50 kg, body mass index between 19 and 28kg/m2. No bad habits such as smoking or alcohol, and no history of drug abuse. Subjects are willing to have no birth plan in the next 6 months and voluntarily take effective contraceptive measures. Volunteered to participate in the clinical trial, understood the study procedures and signed the written informed consent. Able to complete the study according to the test protocol.  Exclusion Criteria:  Abnormal results of vital signs, physical examination, electrocardiogram and other laboratory examinations were clinically significant. With the central nervous system, cardiovascular system, liver and kidney function is not complete, the digestive system (not included in the drug delivery two weeks ago suffering from acute gastroenteritis, diarrhea), respiratory system (not included in the drug delivery two weeks ago with upper respiratory infection), metabolism and skeletal system disease, or any other may affect the results of the study of disease and physiological conditions. A history of hospitalization or surgery within 3 months prior to the trial. Known active hepatitis B, HIV, HCV and Treponema pallidum infection. Have a history of specific allergic reactions (such as atopic dermatitis, asthma, etc.), or have a history of allergy to drugs and biological agents, or have a history of known allergy to the ingredients of this drug. Positive alcohol and urine drug screening. Regular drinkers who consumed more than 14 units of alcohol per week (1 unit is 360 mL beer or 45 mL liquor of 40% alcohol or 150 mL wine) during the 3 months prior to the trial. Smoking more than 5 cigarettes per day within 3 months before the trial. Participate as a subject in any drug clinical trial within 3 months prior to the trial. People who had donated blood or lost more than 400mL of blood in 3 months before the experiment. Have taken any prescription drugs during the 14 days prior to the trial. Have taken any over-the-counter medicines, any functional vitamins or herbal products within 48 hours prior to the trial. Have consumed any xanthine-rich beverage or food or grapefruit fruit or products containing grapefruit within 48 hours prior to the test. Have consumed any food or drink containing caffeine (such as tea or coffee) and any alcoholic products within 48 hours before the trial. Have special requirements on diet and fail to follow the diet and corresponding regulations provided. Subjects who are considered by the investigator to have poor compliance or have any unsuitable factors for participating in the study.