Inclusion Criteria:  • Must be age between 35 and 70 years old;  Clinical diagnosis of metabolic syndrome;  Exclusion Criteria:  • Must be able to have no acute knee injury such as car crash or acute sports injury;  Must be able to have no knee surgeries history; Must be able to have no rheumatoid arthritis or serious knee osteoarthritis with deformity; Must be able to have no contraindications to MRI; Must be able to have no severe cardiopulmonary disease; Must be able to have no musculoskeletal or neuromuscular impairments ; Must be able to have good visual, hearing, or cognitive;