Inclusion Criteria:  Age ≥ 18 years World Health Organization (WHO) status ≤ 2 Colorectal adenocarcinoma in progression after first line metastatic chemotherapy Able to understand and read French Visual Analog Scale (VAS) fatigue ≥ 4 Patient starting a second or third line of metastatic chemotherapy Patient having signed the informed consent Patient subscribing to a French Social Security system  Exclusion Criteria:  Patients without phones or devices for sessions at home Bradycardia (< 50 beats/minute) with β-blockers Known severe heart failure with ventricular ejection fraction < 40%. Presence of known or symptomatic brain metastases Chronic pain evolving for more than three months and using morphine Patient used to and having a regular and habitual practice of relaxation techniques such as yoga, hypnosis, sophrology, meditation. Medical (neurological, psychiatric, etc.) or psychological conditions that do not allow participation in the protocol (filling out the questionnaires, the booklet, as well as following the sessions) Hearing-impaired patient without hearing aids Patient under guardianship or legal protection