Inclusion Criteria:  Patients with bilateral idiopathic gonarthrosis aged 18 to 65 years; Representatives of the Kazakh ethnic group up to the 3rd generation; Hereditary history of arthrosis; Persons who are able and willing to provide written informed consent;  Exclusion Criteria:  Patients with bilateral idiopathic gonarthrosis under 18 years of age and over 65 years of age; Representatives of other ethnic groups; Representatives of the Kazakh ethnic group less than 3 generations; No family history of bilateral idiopathic gonarthrosis; Patients with an acute period of the inflammatory process (laboratory and clinical signs); Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent; Pregnant or lactating women; Tuberculosis of any localization in the active phase and in history; Severe and decompensated diseases of the liver and kidneys, cardiovascular system; Severe and decompensated course of endocrine diseases; Autoimmune diseases; Systemic diseases; Oncological diseases;