Key Inclusion Criteria:  Males and females, 46 years of age or older A diagnosis of primary open-angle glaucoma, who are candidates for medical therapy, laser treatment, or glaucoma-filtering surgery Pseudophakic with prior uncomplicated cataract surgery  Key Exclusion Criteria:  Angle closure, congenital, or secondary glaucoma Diagnosed degenerative visual disorders Clinically significant intraocular inflammation or infection