Inclusion Criteria:  Patients with Post Schizophrenic Depression according to ICD10-DCR (International Classification of Diseases 10- Diagnostic Criteria for Research). Aged between 18 to 60 years of either sex Patients with a positive score of less than 29 on the Positive and Negative Syndrome Scale (PANSS) [88] Patients with a score of more than 6 on the Montgomery-Asberg Depression Rating Scale (MADRS) [89-90] Patients without Extrapyramidal symptoms: a score of less than 3 on the Simpson-Angus Scale [91] With Informed consent from the Legally Authorised Relative  Exclusion Criteria:  Patients with a medical or neurological disorder Patients with a history of substance dependence Patients with high suicidality Patients with a past history of primary depression Patients already on Olanzapine-Fluoxetine combination or Amisulpride