Inclusion Criteria:  Age more or same than 18 years old Defined as metabolic syndrome patients based on NCEP-ATP III Criteria with modified of obesity classification (waist measurement) for Asian population Agreed to participate in this study  Exclusion Criteria:  Allergic to Ganoderma lucidum Pregnant woman Participate in another drug or medical device study Waiting for an organ transplantation or have undergone a transplant Cancer patients who undergoing a chemotherapy or radiotherapy People with organ failure Could not be randomized and participate in this study by clinical judgement