Inclusion Criteria:  Age 19 or over at time of informed consent.  Diagnosis of metastatic renal cell cancer (mRCC) with no prior systemic therapy for mRCC.  Prior surgery and radiation therapy are permitted. Prior neoadjuvant and adjuvant therapy for non-metastatic renal cell carcinoma are permitted. Patients currently not on therapy and being observed are permitted. Evidence of signed and dated informed consent document indicating that the patient has been informed of all pertinent aspects of the study. Ability to comply with completion of PROs  Exclusion Criteria:  Patients being treated for active malignancies other than mRCC are excluded, unless all systemic therapy was completed at least 3 months prior to enrollment.