Inclusion Criteria:  To be eligible to this trial, patients must fulfill the following inclusion criteria:  Have a histologically confirmed, treatment-naive metastatic pancreatic ductal adenocarcinoma with liver metastases. Be at least 18 years or older at the time of signing the informed consent. Have a life expectancy of at least 12 weeks. Performance status of 0 or 1 on the Eastern Cooperative Oncology Group (ECOG) scale. Have measurable disease as assessed by RECIST v1.1. Agrees and amenable to a tumor and liver biopsy at baseline and on day 41 +/- 3 days. Patient that are anticoagulated at baseline are eligible provided it is deemed safe by the investigator to stop anticoagulation momentarily in order to safely proceed to a biopsy. Eligible to standard-dose FOLFIRINOX as assessed by the principal investigator or a sub-investigator. Demonstrate normal organ function as defined below. These assessments must be done within 7 days of Cycle 1 Day-7. Provide written informed consent and able to follow the trial treatment and visit schedule. For Women Of Child-Bearing Potential (WOCBP), a negative serum pregnancy test must be obtained prior to receiving the study medication. WOCBP should agree to use 2 different methods of birth control OR abstain from heterosexual intercourse for the duration of the trial and up to 90 days after the last study medication administration. Male subjects should agree to use an adequate method of contraception for the duration of the trial and up to 90 days after the last study medication administration. Male subjects should refrain from donating sperm during this period.  Exclusion Criteria:  To be eligible to this trial, patients must not fulfill any of the following exclusion criteria:  Known additional malignancy that is progressing or that requires treatment. Exceptions include basal cell carcinoma of the skin, in situ bladder or in situ cervical cancer. Other malignancy may be eligible after consultation with the chief investigator. Spinal cord compression or brain metastases unless treated, stable and not requiring steroids for at least 4 weeks prior to the initiation of study treatment. Baseline myalgia or myositis of any etiology. Prior treatment with FOLFIRINOX in the adjuvant setting. History of clinically significant intolerance or myositis with any statin. History of clinically significant intolerance or hypersensitivity to PCSK9 inhibitors or ezetimibe. Baseline grade 2 ULN Creatine Phosphokinase (CPK) elevation. Liver tumor burden that is deemed unsafe by the investigator. Major surgery or procedure from which the patient has not yet recovered. Any medical condition that puts the patient at high medical risk, including but not limited to active uncontrolled infection or active bleeding diathesis. Any history of disease that, in the opinion of the investigator, puts liver function at risk including but not limited to autoimmune hepatitis or history of hepatitis B, hepatitis C or human immunodeficiency virus (HIV). Screening at baseline for those conditions is not required. Use of any drugs that are contraindicated as per protocol and that cannot be changed or modified to an acceptable alternative.