Inclusion Criteria:  Subjects must meet all the following inclusion criteria to be eligible for participation in this study  18<age≤85； Patients with hypertrophic cardiomyopathy and without hypertrophic cardiomyopathy undergoing coronary angiography and echocardiography; Willing to sign informed consent.  Exclusion Criteria:  Subjects who meet any of the following exclusion criteria are not to be enrolled in this study  All coronary arteries can not be shown clearly in coronary angiography Prior coronary artery bypass surgery, valve prosthesis Connective tissue disease Cardiac dilatation(left ventricular end diastolic diameter, ≥55mm male，≥50mm female ) Congenital heart failure, LVEF<35% Coronary total occlusion, changes in coronary morphology, such as long stents implantation