Inclusion Criteria:  Malignant bone tumor of the femur and finished neoadjuvant chemotherapy Candidate for resection and reconstruction by prosthesis. 3- Age 4-18 years.  Exclusion Criteria:  Anatomic location other than femur de Reconstruction other than prosthesis Allergy to TXA Previous history of DVT Previous history of renal dysfunction Congenital or acquired coagulopathy. Congenital or acquired cardiomyopathy. Previous history of convulsions.