Inclusion Criteria:  Age ≥ 18 years. Availability of nasopharyngeal swab from SOC SARS-CoV-2 infection as assessed by a positive RT-PCR test (CT < 32), including in SARS CoV-2 vaccinated or previously infected patients Patient admitted in the ICU for acute respiratory failure (SpO2 ≤ 90% and need for supplemental oxygen or any kind of ventilator support; i.e., OMS 10-category ordinal scale ≥5) Patient or trusted person or close or relative, And, accepting study participation  Exclusion Criteria:  Patient with SARS-CoV-2 infection but no acute respiratory failure Patient deprived of liberty or under legal protection (guardianship, curators, legal protection, forced hospitalization)