Inclusion Criteria:  an endogenous hypercortisolism (group 1) a disease justifying the next start of glucocorticoid therapy (group 2) chronic adrenal insufficiency (group 3) subjects with either diabetes, hypertension or osteoporosis, but without glucocorticoid excess (control group) patients will have to be affiliated to a social security scheme patients should be able to understand the study and able to express their consent  Exclusion Criteria:  patients with reduced life expectancy, less than 2 years pregnant or lactating women patients refusing the protocol patients under state medical assistance