Inclusion Criteria:  Male or female 12 to 21 years of age, inclusive Have a diagnosis of SCN8A-DEE supported by both clinical and genetic findings Have on average at least 1 countable motor seizure per week and not be seizure-free for more than 20 consecutive days Being treated with at least 1 other antiseizure medication (ASM), but no more than 4 ASMs Have failed to achieve seizure freedom with at least 2 ASMs Must be using a nocturnal alerting system or practice consistent with standards of care at the time of screening and continue to use this for the duration of the study Must have an adequate rescue medication regimen per the investigator's judgment in place at the time of screening and for the duration of the study Have a body weight of at least 10 kg The subject's parent/caregiver is able to accurately identify seizure types, especially countable motor seizures (defined as GTCS, tonic, atonic or FOS with noticeable motor component) and is able to complete seizure diary  Exclusion Criteria:  Have previously been enrolled in this study and received blinded treatment Have participated in an interventional clinical trial < 30 days prior to screening Have symptoms that would be more consistent with another epilepsy disorder such as Dravet syndrome (eg, fever-induced episodes of status epilepticus, frequent myoclonic seizures, worsening on sodium channel blockers) Are currently receiving cannabinoids or medical marijuana except Epidiolex/Epidyolex, unless approved by the Sponsor Are currently taking systemic steroids (excluding inhaled medication for asthma treatments). If subject has received these medications in the past, must be off these medications for at least 3 months prior to the screening visit and these drugs may not be initiated during the duration of the study. Intermittent steroids to treat nonepilepsy related diseases (such as allergies or dermatological conditions) are not exclusionary Have a history of moderate or severe head trauma or other neurological disorders or systemic medical diseases that are, in the investigator's opinion, likely to affect nervous system functioning Have a clinically significant medical condition or chronic disease, that in the opinion of the investigator would preclude the subject from participating in and completing the study or that could confound interpretation of study outcome Have clinically significant abnormal vital signs at the screening visit as determined by the investigator Have one or more clinical laboratory test values outside the reference range, based on blood samples taken at the screening visit, that are of potential risk to the subject's safety as determined by the investigator Have, at the screening visit, an electrocardiogram (ECG) finding of a corrected QT interval using Fridericia's formula (QTcF) > 450 msec or presence of any significant cardiac abnormality