Inclusion Criteria:  An individual must meet all the following criteria to be eligible to participate in this study:  A male or female ≥6 months of age who has been diagnosed with a complement-mediated disease in which a reasonable etiological association with CFI deficiency has been reported Affirmation of participant's informed consent or LAR's willingness to provide informed consent with signature confirmation before any study-related activities. (Study-related activities are any procedures that would not have been performed during normal clinical management of the participant.) The participant (if a minor) must be willing to give written informed assent if the minor is within the age groups 7 to 11 years old and 12 to 17 years old.  Exclusion Criteria:  1) Diagnosis of age-related macular degeneration that is complement-related with no concurrent systemic complement involvement