Inclusion Criteria:  Age> 18 years Clinical indication for simple tooth extraction in the posterior sectors (from the second premolar to upper and lower second molars) Need to place a dental implant in the same position of the extraction Availability of observation during the period of treatment Signature of the informed consent  Exclusion Criteria:  Third molars Active periodontal disease Simultaneous extraction of two adjacent pieces in the same quadrant Oral dehiscence ≥ 25% Alveolus depth <7mm Loss of some wall of the alveolus Severe inflammation in the extraction area Previous diagnosis of coagulopathies Previous diagnosis of autoimmune disease Be receiving, or have received the 30 days prior to extraction treatment with radiotherapy, chemotherapy, immunosuppressants, systemic corticosteroids or anticoagulants Regular treatment with NSAIDs History of chronic hepatitis or liver cirrhosis Positive markers for HCV, AfHBs, HIV-I / II or TP Diabetes mellitus with poor metabolic control (evidence of glycated hemoglobin> 9%) Dialysis treatment Presence of malignant tumors, hemangiomas or angioma in the extraction area. History of ischemic heart disease in the last year Pregnancy or women of childbearing age who do not take action contraceptives Lactating women Previous diagnosis of metabolic bone disease Antiresorptive treatment Treatment with monoclonal antibodies Smoker> 10 cigarettes / day Any inability to participate in the study