Inclusion Criteria:  Provision of signed and dated informed consent/assent form Prescribed and treated with Carbaglu®  Have an established diagnosis of PA or MMA defined as follows:  Diagnosed with PA by semi quantitative urine organic acid analysis, defined as presence of elevated methylcitric acid and normal methylmalonic acid levels and no evidence of biotin related disorders in the organic acid analysis; OR Diagnosed with MMA by semi quantitative urine organic acid analysis, defined as elevation of methylmalonic acid and no evidence of vitamin B12 dependent disorder on plasma amino acid analysis (vitamin B12 dependency is defined by documented vitamin B12 responsiveness).  AND/OR  Confirmation by molecular genetic testing  Exclusion Criteria:  None