Inclusion Criteria:  Adult patient, male or female, treated long term with an oral anticoagulant (anti-vitamin K or direct), admitted to a hospital emergency department for intracerebral, digestive or intramuscular hemorrhage, defined as major according to the criteria of the International Society of Thrombosis and Haemostasis1. These three sites of bleeding are the most common. Capable of giving informed consent to participate in research or in the event of emergency care for a reference person. Affiliated with a Social Security scheme.  Exclusion Criteria:  Incapable major. Administration within the last 24 hours of parenteral anticoagulant. Refusal of participation. Pregnant or breast feeding mother