Inclusion Criteria:  Age ≥60 years Diagnosis of HFpEF by either H2FEPF score of 6-9 or HFA-PEFF score of 5-6, or invasively confirmed diagnosis of HFpEF (resting pulmonary capillary wedge pressure ≥15mmHg or ≥25mmHg with exercise). Diagnosis of computable phenotype of frailty rests on screening questions about ability to climb two flights of stairs, activities of daily living, living environment, wearing of dentures/hearing aids, and whether the patient uses assistive devices.  Exclusion Criteria:  Reduced ejection fraction (≤50%) with or without prior history of myocardial infarction Acute coronary syndrome <3 months Uncontrolled diabetes mellitus (HbA1C>8) Uncontrolled hypertension (>160/100mmHg, despite 3 antihypertensive medications) Nephrotic syndrome or eGFR <30mL/min/1.73m2 Cirrhosis Hepatitis B/C positive Elevated lived enzymes (AST/ALT>3ULN Prior malignancy other than basal cell carcinoma History of ongoing, chronic or recurrent infectious disease Suspected/proven immunocompromised state Uncontrolled hyperlipidemia (fasting TG >400 mg/dL (>4.5 mmol/L) or total cholesterol >300 mg/dL (>7.8 mmol/L) despite maximum lipid lowering therapy Class IV HF symptoms