Inclusion Criteria for affected individuals (primary participants) include:  Clinical diagnosis or suspicion of ALS or a related disorder, including, but not limited to, ALS-FTD, PLS, HSP, FTD, Multisystem Proteinopathy (MSP) and PMA. Subject is able and willing to comply with study procedures  Exclusion Criteria for affected individuals (primary participants) include:  Subjects with a condition or who are in a situation which, in the PI's opinion, could confound the study finding or may interfere significantly with the individual's participation and compliance with the study protocol -- including but not limited to neurological, psychological and/or medical conditions  Inclusion criteria for biological family members (secondary participants) include:  Family member of an enrolled affected primary participant  Exclusion Criteria for biological family members (secondary participants) include:  Subjects with a condition or who are in a situation which, in the PI's opinion, could confound the study finding or may interfere significantly with the individual's participation and compliance with the study protocol -- including but not limited to neurological, psychological and/or medical conditions