Inclusion Criteria:  1) Age 18-70, regardless of gender; 2) HP positive in 13C/14C breath test or pathological test; 3) HP eradication has never been performed in the past; 4) Based on the consensus of helicobacter pylori in 2017, it conforms to the HP eradication guideline; 5) The patient voluntarily signed the informed consent.  Exclusion Criteria:  1) History of drug allergy in this study; 2) liver and kidney dysfunction; 3) cardiopulmonary insufficiency; 4) History of malignant tumor; 5) Taking clopidogrel, warfarin and other drugs simultaneously may affect CYP2C19 metabolism; 6) Pregnant or lactating women; 7) Patients with severe mental illness; 8) those planning pregnancy; 9) Previous upper gastrointestinal surgery history; 10) Participated in any other clinical investigator in the last 3 months.