Inclusion Criteria:  Admitted to the Pediatric Intensive Care Unit (PICU), Cardiac Intensive Care Unit (CICU), or Neonatal Intensive Care Unit (NICU) at participating institution  Exclusion Criteria:  Baseline Chronic Kidney Disease (CKD) Stage IV or V (estimated GFR <60 mL/min/1.736m2) History of kidney transplant within the previous 90 days Ongoing AKI or Acute Kidney Disease (AKD) at ICU admission requiring renal replacement therapy initiated prior to ICU admission Acute DNR order or clinical team is not committed to escalating medical care Anticipated to require intensive care for less than 48 hours