Inclusion Criteria:  Subject has a body mass index (BMI) in the range of 18.5 and 35.0 kg/m2 (inclusive); Subject is in good physical health in the opinion of the principal investigator (PI); Subject is in good mental health in the opinion of the PI and clinical psychologist;  Exclusion Criteria:  Has known allergies or hypersensitivity or any other contraindication to 5-MeO-DMT; Has received any investigational medication within the last 4 weeks; Has a medical condition, which renders the subject unsuitable for the study.