Inclusion Criteria:  Men with suspicion of clinically significant prostate cancer with prior inconclusive, discordant or negative magnetic resonance imaging/ultrasound (MRI/US) fusion prostate biopsy Scheduled for a repeat transrectal ultrasound (TRUS) prostate biopsy by standard of care Focal 68Ga-PSMA-11 uptake within the prostate  Exclusion Criteria:  Negative 68Ga-PSMA-11 uptake within the prostate (screening failure) Age < 18 and > 90 years Recurrent prostate cancer Inability to provide written informed consent Known inability to remain still and lie flat for the duration of the PET/CT (about 30 minutes)