Inclusion Criteria:  Patient ≥ 18 years Histologically confirmed melanoma patient Patient for whom treatment by targeted therapy or immunotherapy is prescribed as an adjuvant or curative treatment In the case of adjuvant treatment, the tumor must be completely removed Patient included in the Ric-Mel cohort Patient informed of the objectives and modalities of the study and having received the information form and having given his/her written consent to participate in the research Patient affiliated to a social security system  Exclusion Criteria:  Patient already treated medically for melanoma Palliative care patient management Pregnant or breastfeeding women Patient under guardianship or curatorship refusal of the patient to participate in the study, or refusal of the patient to allow a portion of his/her previously collected skin sample to be used in the present research