Inclusion criteria:  Patients with three different CNS groups of tumors: from III and IV brain tumor groups, and metastatic tumors enrolled to RT, Age between 18-70 years, good general health conditions (according to Eastern Cooperative Oncology Group (ECOG) 0-2), obtaining informed consent for participation in the study.  Exclusion criteria:  Patients with numerous tumors (above two), psychological or psychiatric illnesses treated pharmacologically, neurological disorders (e.g. MS, Parkinson's disease, meningitis, etc.), significant clinical circulatory failure (above III NYHA).