Inclusion Criteria:  Healthy volunteers, male or female 18-55 at the time of informed consent In good health as determined by the principal investigator Body weight of ≥ 50 kg and BMI within the range 18-30 kg/m2 (inclusive). Chinese subjects are eligible to be included in the study if all of the following criteria apply in addition to the above: Must have been born in China, with 2 Chinese biological parents and 4 Chinese grandparents as confirmed by interview; Must have lived no more than 10 years outside of China; Must not have changed their lifestyle or habits significantly, including diet, since leaving China.  Exclusion Criteria:  Any current history of clinically significant disease in the opinion of the investigator or receiving maintenance medications on a daily basis. Any active or unstable clinically significant medical or psychiatric condition as judged by the investigator. Smokes cigarettes or uses other nicotine-containing products (eg, snuff, nicotine patch, nicotine chewing gum, mock cigarettes, or inhalers), and has done so in the 3 months prior to screening. Regular alcohol consumption within 6 months prior to the study defined as: an average weekly intake of > 20 units for males or > 16 units for females. One unit is equivalent to 8 glasses of alcohol: a half pint (∼240 mL) of beer, 1 glass (125 mL) of wine or 1 (25 mL) measure of spirits.