Inclusion Criteria:  Patients after the first week of their treatment till the end of their treatment protocol and at their follow-up visits patients who completed ESAS questioner Male and female patients from 20 -70 years old who are diagnosed with head and neck cancer.  Exclusion Criteria:  Patients who didn't start their treatment before the examination Patients who refuse to participate in the study. Patients with leukemia or blood cell cancers, infants and children