Inclusion Criteria:  Helicobacter pylori-positive participants determined by ¹³C-urea breath test, ¹⁴C-urea breath test, HE stain or bacterium culture With no historical treatment for helicobacter pylori infection.  Exclusion Criteria:  Administration of antibiotics, bismuth in 4 weeks prior to inclusion or antacids including H2 receptor antagonist, proton pump inhibitor and potassium-competitive acid blocker in 2 weeks prior to inclusion Active peptic ulcer with complications such as hemorrhage, perforation, obstruction, cancerization, etc. With previous esophageal or gastric surgery With severe systemic diseases, major organ like heart, lung, brain diseases, liver or kidney insufficiency, malignant tumor or other diseases Allergy to any of the study drugs Pregnancy or in lactation Participated in other research within 3 months，cannot express his/her own ideas correctly or cannot cooperate with the researcher