Inclusion Criteria:  Healthy, non-smoking, adult males or females aged 18-60 Body mass index of 18 to 32 mg/m2 at Screening Medically healthy with no clinically significant medical history, physical examination, laboratory profiles, vital signs or ECGs If of reproductive age, willing and able to use a medically highly effective form of birth control 30 days prior to first dose, during the study and for 30 days following last dose of study medication Understands the study procedures in the informed consent form and be willing and able to comply with the protocol  Exclusion Criteria:  History or presence of clinically significant medical or psychiatric condition or disease History of any illness that might confound the results of the study or poses an additional risk to the subject by their participation in the study History or presence of alcohol or drug abuse within the past 2 years prior to the first dosing History of prolonged QT syndrome or a QTc interval with Fridericia's correction (QTcF) > 450 msec for males or QTcF > 470 msec for females obtained at Screening visit or prior to the first dosing Females who are nursing, pregnant, or planning to become pregnant while in the study, and for 30 days after last dose of study drug Positive results at Screening for human immunodeficiency virus, hepatitis B surface antigen or hepatitis C virus A positive test or history of incompletely treated or untreated tuberculosis