Inclusion Criteria:  female: Hb<11 g/dL; male: Hb<13.5 g/dL has no allergic reaction to TCM  Exclusion Criteria:  below 20 years old ever drug abuse or still in drug abuse pregnant or in breast-feeding women with psychotic disorders cardiac arrhythmia with pacemaker dyscoagulation or thrombocytopenia (platelet< 15000/uL) or liver dysfunction (> 2 fold normal range) with severe disease (cardiac arrest, heart failure, COPD, GI bleeding, etc.) under another clinical trials