Inclusion Criteria:  Age ≥18 years and Age ≤75 years; Scheduled for laparoscopic gastrointestinal surgical procedure with general anesthesia ; The score evaluated by Apfel simplified PONV risk assessment systems is ≥3.  Exclusion Criteria:  The American Society of Anesthesiologists (ASA) rating is >3; Severe hepatic dysfunction(the score of Child-Pugh is >9); With contraindications for using fosaprepitant, 5-HT3 receptor antagonist or dexamethasone ; Take medications with known antiemetic properties preoperatively ; With mental disorder, or not be able to communicate ; Pregnant women or nursing mothers.