Inclusion Criteria:  Patients diagnosed clinically as ischemic stroke; Age ≥ 40 years; Onset time ≤ 3 months; Informed consent was signed.  Exclusion Criteria:  Patients with symptomatic intracranial hemorrhage; bleeding lesion > 10 mm was found on SWI; Vascular malformations, tumors, abscesses or other major non ischemic brain diseases were present; There are contraindications for antithrombotic drugs use; Serious systemic diseases; Refusal to sign informed consent or poor compliance.