Inclusion Criteria:  The clear diagnosis of MINOCA, acute myocardial infarction（AMI) and unstable angina（UA) in BIpass The clear diagnosis of MINOCA from the multi-center cohort  Exclusion Criteria:  Prior surgery (cardiac or non-cardiac), trauma or clinically evident coagulopathic bleeding (e.g. gastrointestinal, genitourinary, et al) Patient with non-cardiac co-morbidities with life expectancy less than 12 months Patients unwilling or unable to comply with all clinical follow-up schedules