Inclusion Criteria:  Pathologically confirmed advanced malignancies that failed, or not suitable for standard treatments; At least 1 measurable lesion. ECOG score 0 or 1; Life expectancy of ≥ 3 months;  Exclusion Criteria:  Known hypersensitivity to any ingredient of TWP-102; Receiving any anti-cancer drugs within 4 weeks; History of serious systemic diseases; History of serious autoimmune diseases; Persistent toxicity of National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 5.0 Grade > 1 severity that is related to prior anti-cancer therapy. (except alopecia) Pregnancy or lactating women.