Inclusion Criteria:  Written informed consent signed prior to the performance of any study procedures Male or female volunteers, age 18 to 65 years, inclusive Overweight to obese (BMI 28.0 - 40.0 kg/m2) Magnetic resonance imaging derived proton density fat fraction (MRI-PDFF) ≥ 10% If subject has Type 2 diabetes mellitus (T2DM), on stable regimen, for at least 3 months prior to screening, of any combination (1) diet and exercise, (2) metformin with absent or mild gastrointestinal symptoms (nausea, vomiting or diarrhea), and/or (3) sodium glucose cotransporter-2 (SGLT-2) therapy  Exclusion Criteria:  Women who are pregnant or breastfeeding Type 1 DM and/or insulin-dependent T2DM, or uncontrolled T2DM defined as HbA1c ≥ 10% or fasting blood glucose ≥ 200 mg/dL (11.1 mmol/L) History of pancreatitis or hypersensitivity reaction to GLP-1 analogues