Inclusion Criteria:  Aged between 18 - 75 years old First-time ST-segment elevation myocardial infarction based on the newest ESC guidelines Timely primary percutaneous coronary intervention within 12 hours from onset Written informed consent acquired  Exclusion Criteria:  Known history of or persistent clinical chronic heart failure prior to randomization Previous use of ARNI, or intolerance or contraindications to study drugs including ARNI or ACEI History of significant chronic coronary obstruction and adverse ventricular remodeling History of any cardiomyopathy, valvular heart disease, congenital heart disease, stent or CABG, or planned open-heart surgery within 3 months History of hepatic impairment or history of cirrhosis with evidence of portal hypertension History of chronic renal dysfunction, or eGFR < 30 ml/min/1.73 m2 History of malignancy and with a life span less than one year Patients with a known history of angioedema related to previous ACEIs/ARB therapy. With contraindication to MRI examination (pacemaker and claustrophobia) or cannot finish breath-holding when lying on the examination bed Pregnancy or nursing women