Inclusion Criteria:  Adult subjects with early stage melanoma (stage I-II) Patients must be undergoing wide local excision +/- sentinel lymph node biopsy Patients must be capable of giving written informed consent, which includes compliance with the requirements and restrictions listed in the consent form  Exclusion Criteria:  Use of antibiotics within the three months prior to surgery Allergy, sensitivity or anaphylaxis to beta-lactam or cephalosporin antibiotics Presence of an infection at the time of surgery Increased risk of infection due to a co-existing medical condition as determined by the surgical team or principal investigator (PI) Subjects with a condition requiring systemic treatment with either corticosteroids (> 10 mg daily prednisone equivalents) or other immunosuppressive medications within 14 days of study drug administration American Society of Anesthesiologists (ASA) grade > IV Refusal to participate in the study Patients who are pregnant will not be included in this study