Inclusion Criteria:  Age ≥ 18 years. Serum ALT and AST are both ≤ 80 U/L. HIV and TPHA screening were negative. Body temperature ≤37.0℃.  Exclusion Criteria:  Patients who confirmed the diagnosis of liver cancer by imaging examination (CT/MRI/B scan). Patients who are allergic to any component of the vaccine, or have a serious history of vaccine allergy. Women who is pregnant, breastfeeding, or planning to be pregnant within 6 months. Patients with cardiovascular diseases, such as arrhythmia, conduction block, myocardial infarction, and severe hypertension can not be well controlled by drugs. Patients with severe chronic diseases or diseases can not be controlled well during the progress, such as asthma, diabetes, thyroid disease, etc. Congenital or acquired angioedema / neuroedema.c. Patients with urticaria within a year. Patients with coagulation disorder. Faintng during acupuncture treatment . Patients who received other investigational drugs within one month. Be receiving anti-TB treatment. Other conditions determined by the researcher.