Inclusion Criteria:  Age 6-59 months Weight ≥ 5.0 kg Axillary temperature ≥ 37.5C or history of fever in the past 24 hours Hemoglobin ≥7 grams/deciliter at enrolment Slide-confirmed mono-infection with Plasmodium falciparum and asexual parasite density between 2,000-200,000 parasites/μl Live within the catchment boundaries of the study site (10km radius) Able to swallow oral medication Able and willing to comply with the protocol for the duration of the study Able and willing to comply with the study visit schedule on days 2, 3, 7, 14, 21, 28, 35, and 42 Parent or caregiver has access to a phone and agrees to have study staff contact them for visit reminders during study period Written informed consent provided by parent/guardian  Exclusion Criteria:  Presence of severe malaria or danger signs, including prostration, alteration in level of consciousness, respiratory distress, convulsions, or jaundice Severe malnutrition according to WHO child growth standards (weight for age <3 standard deviations) Known hypersensitivity to AL or DP Use of antimalarials or other drugs with antimalarial activity in the last 2 weeks General clinical condition necessitates hospitalization Evidence of concomitant infections at the time of presentation Plan to travel or leave the area within the next 3 months Previously enrolled in this study