Inclusion Criteria:  18 years old ≤age≤65 years of age,male. Hemophilia A or B patients with inhibitors. Peak historical inhibitor titer ≥ 5 BU and a positive inhibitor test when enrolled. Establish proper venous access. Agree to use adequate contraception to avoid pregnancy. Provide signed informed consent.  Exclusion Criteria:  Have any coagulation disorder other than hemophilia A or B. Treat with prophylactic treatment of coagulation factor. Treat with anticoagulant within 7d of the time of study drug administration. Have a history of arterial and/or venous thromboembolic events. Have platelet count <100,000/mL,hemoglobin<90g/L. Severe liver or kidney disease. Accept major operation or blood transfusion within 1 month of the time of screening. Have a known allergy to Blood product. Participate in other clinical research within 1 month of the time of study drug administration.