Inclusion Criteria:  Subjects must be able to understand and provide informed consent. Males or females, between 21 and 45 years of age, inclusive; Body mass index must be within the range of 18.5 to 32.0 kg/m2; 12-lead electrocardiogram (ECG) within normal limits with no clinically significant abnormalities in the opinion of the Investigator； Systolic blood pressure ≤140 mmHg and a diastolic blood pressure of ≤ 90 mmHg after 5 minutes with supine rest； non-pregnancy meningococcal vaccinations for at least 2 weeks before dosing  Exclusion Criteria:  Disease or conditions interfere with participating the trial Active serious mental illness or psychiatric disorder clinically relevant abnormal test results in hepatic function unacceptable CBC lab test asymptomatic complement deficiency Any other clinical safety laboratory test HIV, HBV, HCV positive Alcohol and drug abuse etc.