Inclusion Criteria:  Patients with RRMS Patients diagnosed as SPMS with relapse All the patients taking other DMTs and their medication had been changed to Cinnomer® due to any reason. 0 ≤ EDSS ≤ 5 18 ≤ Age ≤ 60  Exclusion Criteria:  History of hypersensitivity to Glatiramer Acetate, mannitol, or any component of the formulation. In the investigator's opinion, any reason that makes the subject unsuitable for treatment with Cinnomer®.