Inclusion Criteria:  Patients (≥ 18 years of age) with diagnosis of NSCLC or breast cancer amenable to medical or radiation therapy with curative or palliative intent Evidence of a personally signed and dated informed consent form document indicating that the patient has been informed of all pertinent aspects of the study Able to read and understand Danish Willing and able to complete collection of data including WGS  Exclusion Criteria:  Patient with breast cancer initiating adjuvant systemic therapy In the judgment of the investigator, the patient's life expectancy is fewer than 3 months at the time of diagnosis of NSCLC or breast cancer