Inclusion Criteria:  Age>=18Y Good Organ Function Expected survival time ≥ 3 months advanced BRAF V600 NSCLC that have been diagnosed histologically or cytology and have failed standard treatment or unable to receive, or refusing standard care. Previous failure to standard treatment, or insuitability for standard treatment or refuse standard treatment. ECOG score 0-2; Exclusion Criteria: Previous treatment with BRAF inhibitors or MEK inhibitors Presence of EGFR mutations or ALK rearrangements (unless disease progression following prior treatment with tyrosine kinase inhibitors). Symptomatic brain or meningeal metastases (unless the patient has been on > treatment for 1 months, has no evidence of progress on imaging within 4 weeks prior to initial administration, and tumor-related clinical symptoms are stable). Current or former patients with interstitial lung disease; Severe active infections requiring systemic anti-infective therapy A history of other malignancies within two years, except for cured cervical carcinoma in situ, basal cell carcinoma of the skin, adenocarcinoma in situ of the lung, or tumors that do not require interventional treatment after radical surgery. Other anti-tumor treatments, such as chemotherapy, targeted therapy, or radiation therapy (except palliative radiation therapy), may be given during the study period.