Inclusion Criteria:  Age 20 years or older. Ability to give informed consent. An naive major papilla. Transient bleeding after endoscopic sphincterotomy Bleeding less than 30 secs when end of procedure  Exclusion Criteria:  Prior endoscopic sphincterotomy. Thrombocytopenia (platelets <50,000/mm3). Liver cirrhosis (Child A-C) CKD stage 4-5 and dialysis. Allergy to epinephrine Prolonged PT/APTT (INR>1.5) Had exposure any antithrombotic or antiplatelet agent in recent 7 days and/or will take those agents in one month after EST Ampulla Vater tumor Active GI bleeding Pregnancy Limited visibility when immediate bleeding after sphincterotomy Still bleeding after 30 secs when end of procedure Recurrent bleeding during ERCP