Inclusion Criteria:  Not myopic patients (<6 Dioptre or <26 mm) Large macular hole >550 μm > 6 months symptoms Signing informed consent  Exclusion Criteria:  Patients with other ocular disease (diabetic retinopathy, glaucoma, uveitis, ocular tumors, etc) Using systemic drugs that are toxic for the optic nerve or retina (chloroquine, hydroxychloroquine, tamoxifen, ethambutol, etc) Patients with ocular surgery