Inclusion Criteria:  Diagnosis of MDD (Diagnostic and Statistical Manual of Mental Disorders V [DSM-V] and (Mini International Neuropsychiatric Interview [MINI] criteria, QIDS-C16≥18) Right-handed No response at a first antidepressant Under AD ≥ 6 weeks No contraindications for rTMS and MRI Absence of addictive comorbidities Absence of severe progressive neurologic and/or somatic pathologies (specially tumors, neurodegenerative diseases) Inpatients or outpatients of Adult Psychiatric Department Signed informed consent form Subjects affiliated to or beneficiary from a French social security regime  Exclusion Criteria:  Subjects under 35 years old or over 65 years old Treated with over 4 AD for the current episode ECT or rTMS for current episode BZD or antiepileptic (except pregabalin up to 75 mg / d, zopiclone ≤7.5 mg / d) Left-handed Subject under measure of protection or guardianship of justice Presence of psychiatric comorbidities Subject beneficiary from a legal protection regime Subject unlikely to cooperate or low cooperation stated by investigator Subject not covered by social security Pregnant woman Subject being in the exclusion period of another study or provided for by the "National Volunteer File