Inclusion Criteria for Chronic Kidney Disease (CKD):  Participant submitted to hemodialysis for more than 3 months Between 18 and 70 yeard old Stable haemoglobin (more than 10 gr/dl) Absence of infectious disease at the date of sample collection and for a period of more than two weeks Absence of active neoplasia Stable vascular access  Inclusion Criteria for controls :  Between 18 and 70 yeard old Absence of chronic kidney disease or dialysis treatment Absence of chronic pathology (including neoplasia) Absence of infectious disease at the date of sample collection and for a period of more than two weeks Spanich residence  Exclusion Criteria for CKD:  Clinical instability Life expectancy of more than 12 months Coagulation system disorders Participation in other clinical study Pregnancy Unsigned informed consent  Exclusion criteria for controls:  Participation in other clinical study Pregnancy Unsigned informed consent