Inclusion Criteria:  Patients diagnosed with new or recurrent myeloid leukemia Aged >= 18 years old Eastern Cooperative Oncology Group (ECOG) performance status < 4 Patient have measurable and amenable to biopsy under local anesthesia without the need for imaging directed procedure Ability to understand and provide signed informed consent Females must be surgically or biologically sterile or postmenopausal (amenorrhoeic for at least 12 months) or if of childbearing potential, must have a negative serum or urine pregnancy test within 72 hours before the start of the treatment. Women of childbearing potential must agree to use an adequate method of contraception during the study and until the last radiation treatment. Males must be surgically or biologically sterile or agree to use an adequate method of contraception during the study and until the last radiation treatment  Exclusion Criteria:  Patients who are unwilling to participate Patients unwilling to undergo the biopsy before or after radiotherapy