Inclusion Criteria:  Age ≥18 years of age ECOG 0-2 Histologically proven hepatocellular carcinoma or proven according to radiological and biochemical criteria (EASL-AASLD) in cirrhotic patients Child-Pugh class A Absence of truncular or lobar portal vein invasion, or suprahepatic vein invasion  Exclusion Criteria:  Uncontrolled replication of hepatitis B virus Transplanted liver Previous abdominal irradiation Previous treatment of HCC with systemic therapy, or with surgical resection in the 2 previous years Metastatic illness