Inclusion Criteria:  Patients must participate voluntarily and sign an informed consent form (ICF), indicating that they understand the purpose and required procedures of the study Patients must be ≥ 18，male Histopathological by Prostate biopsy confirmed prostatic cancer（No Neuroendocrine prostate cancer or small cell carcinoma） High-risk prostate cancer (T2c≤ clinical stage ≤T4 or Gleason score ≥8 or PSA≥20ng/ml) Patients willing to undergo laparoscopic radical resection of prostate cancer and extensive lymph node dissection ECOG PS：0-1  Exclusion Criteria:  Imaging or biopsy confirmed distant Metastatic lesion The number of regional lymph nodes metastasis >3 Patients had undergone The treatment of Systemic chemotherapy and endocrine therapy for prostate cancer Patients had undergone prostate surgery、radical radiotherapy or Bilateral orchidectomy