Inclusion Criteria:  1.18-80 years old 2. NIHSS score>5 3. First stroke, MRI shows anterior cerebral artery and middle cerebral artery obstruction 4. Patients who meet Alteplase thrombolytic therapy within 4.5h  Exclusion Criteria:  Alteplase contraindications Other diseases of the central nervous system There has been a neurological disability in the past (mRS score>2) Difficulty swallowing Arrhythmia, atrioventricular block Use of anti-tumor drugs, other immunosuppressive and immunomodulatory drugs Macular edema Magnetic resonance angiography(MRA) shows obstruction of internal carotid artery and vertebrobasilar artery Hemorrhagic stroke Patients who are known to have hypersensitivity to dimethyl fumarate or any excipients of this product Pregnant and lactating women