Inclusion Criteria:  ≥18 years old PCI and stent implantation indication according to ESC Myocardial Revascularization Guidelines At least 1 stenosis at native coronary anatomy, in a 2-4mm vessel size, that could be treated with 1 or more ihtDEStiny® drug eluting stent Informed consent previous to PCI  Exclusion Criteria:  Patient refusal to participate in the study Pregnancy Other DES implantation during index PCI, or 30 days before of after index PCI PCI at surgical grafts PCI for in-stent restenosis Killip class 3-4 Acute Coronary Syndromes (ACS) High bleeding risk with dual antiplatelet intolerance for at least 3 months (or 6 months for ACS PCI) Allergy or hypersensitivity to sirolimus Patients requiring surgery (cardiac or non-cardiac) in the next 3 months after index PCI Patients with life expectancy <2 years Patients included in other trials or clinical studies