Inclusion Criteria:  Age ≤14 years old; Bone marrow/umbilical blood HCT received high dose cyclophosphamide(>120mg/kg) ； ECOG≤2; Sign an informed consent form (<10 years old, signed by the guardian; ≥10 years old, signed by the child and guardian).  Exclusion Criteria:  Past myocarditis, cardiomyopathy, valvular heart disease, rheumatic heart disease, severe arrhythmia, heart failure, congenital heart disease history; Have heart or pericardial surgery; Have received radiotherapy involving thoracic cavity； Those who do not meet the above entry criteria.