Inclusion Criteria:  Consenting patients fulfilling the Poser's criteria for definite MS Age 18-70 Male and female EDSS rate 5.5-7.5 (moderate to high disability) Failure to two lines of the currently available registered immunomodulatory treatments for MS. The lack of response to these treatments was determined by either an increase in EDSS or the appearance of at least two relapses of MS during the year prior to inclusion.  Exclusion Criteria:  Patients who were treated with cytotoxic medications during the last three months prior to the infusion. Patients suffering from significant cardiac, renal or hepatic failure or any other disease that may risk the patient or interfere with the ability to interpret the results. Patients with active infections. Patients with cognitive decline or inability to understand and sign the informed consent.