Inclusion Criteria:  Consecutive patients presenting to the ED with suspicion of infection Age ≥18 years Written Informed Consent obtained  Exclusion Criteria:  Patients with SARS-COV-2 infection Recent major trauma or surgery End stage renal failure requiring dialysis Terminal disease and/or very severe medical co-morbidity where death has to be expected in the next 6 months, e.g. due to malignancy, cardiac, renal or hepatic failure Patients whose source of infection always requires hospital admission or never requires hospital admission. Patients who cannot be discharged for other than medical reasons Patient participates in any other interventional clinical trial Patients with active abusive drug use Pregnant or lactating women Patients who are institutionalized by official or judicial order Dependents of the sponsor, the CRO, the study site or the investigator