Inclusion Criteria:  Patients group :  Patients included in the HAMA cohort Who is willing to take part in the IVAMA project  Control group :  Grade 2 or 3 hypertension with office blood pressure measurement (above 160 and/or 100 mmHg for systolic and diastolic) Persistence of blood pressure above 160 / 100 mmHg on the average of 3 "attended" blood pressure measurements  Exclusion criteria:  Patients group :  Age < 18 years old Patients with chronic renal failure of stage 3 or higher. Patients with any type of diabetes Patient in per partum Patients who cannot freely give their consent, or patients who refuse to participate Chronic dialysis patient  Control group:  Evidence of subacute involvement of one of the following target organs: brain, kidney, eye, heart, thrombotic microangiopathy. Target organ impairment is defined in the inclusion criteria for the "Patients" group. Presence of known chronic kidney insufficiency of grade 3 or higher Chronic dialysis patient Diabetes of any type Patients who cannot freely give their consent, or patients who refuse to participate