Inclusion criteria:  Men and women aged between 30-65 years old; BMI between 30-40 kg/m2; Waist circumference ≥85 cm for women, ≥90 cm for men; Stable weight in the past 3 months; Plasma triglycerides levels ≥1.5 mmol/L for men and women; Access to a computer and Internet.  Exclusion criteria:  Any severe uncontrolled medical, surgical, neurological or psychiatric condition; Medication for hypertension, dyslipidemias, CVD, T2D or obesity; Medication that may affect the CNS; Gastro-intestinal conditions or disorders likely to impact on absorption; History of nephrolithiasis or urolithiasis; Contraindications to MRI (cardiac pacemaker/defibrillator, cochlear implant or other ear implant, implanted insulin pump or other infusion pump systems, neurostimulator or other electronic/magnetic implant or device, any type of prothesis, aneurysm clips, any metallic fragments, vascular access port, catheter, dental retainer, claustrophobia, surgery in the last 3 months); Anticoagulant/blood thinning medication in the last month; Pregnant or breastfeeding women; Substance or alcohol abuse; Known allergy or intolerance to cranberry; Currently smoking.