Inclusion Criteria:  MS diagnosis was made based on the McDonald criteria valid at the time of diagnosis Written consent by the legal guardians of the participating child following a detailed oral and written education Exposed group (n=40): Children and adolescents (aged 8 to 18 years) of mothers with prenatal exposition to MP in the context of a MS relapse therapy Non-exposed group (n=40): Children and adolescents of mothers suffering from MS without MP therapy during pregnancy (aged 8 to 18 years) matched for age, gender and social background  Exclusion Criteria:  Perinatal complications such as cerebral bleeding, neonatal intensive care with ventilation, prenatal therapy with glucocorticoids except for an MS relapse Maternal abuse of noxious agents during pregnancy Long-term glucocorticoid medication (e.g. asthma) Preterm births (before 36 weeks of pregnancy) Severe disease making an examination impossible (e.g. mental retardation) disease-modifying therapy during pregnancy