Inclusion Criteria:  Patients with esophageal and anorectal symptoms after COVID 19- infection Patients with worsening of esophageal and anorectal symptom after COVID 19- infection, but who had previously described esophageal and anorectal symptoms  Exclusion Criteria:  Other gastrointestinal disease that can influence to results Gastroesophageal reflux H. Pylori infection Bacterial, parasitic, viral and fungal gastrointestinal infection or infestation Myasthenia Scleroderma Diabetes mellitus Thyroidal hyperfunction