Inclusion Criteria:  Regardless of sex, aged 30 or above, hope to treat bilateral motor symptoms and receive the other side treatment plan at the 6th month; Subjects are able and willing to give informed consent and can participate in whole study visits; It was clinically diagnosed as Parkinson's disease and confirmed by functional neurosurgeons; The subjects should respond to levodopa; In the off-medication state, the subjects' MDS-UPDRS scores were 30 or more.  Exclusion Criteria:  The subjects scored 3 or more in the pull-back test; Parkinson's disease symptoms were suspected as the side effects of antipsychotics; severe cognitive impairment confirmed by neuropsychologists; subjects with other neurodegenerative diseases; Subjects with unstable mental illness, defined as active, uncontrolled depression, schizophrenia, delusions, hallucinations or suicide intention; Pregnant or lactating women; Subjects with alcohol or drug abuse; Subjects with unstable heart condition or severe hypertension; Subjects with a history of abnormal bleeding or clotting.