Inclusion Criteria:  The person who voluntarily signed the consent form Adults over 40 years of age Patients who diagnosed with COPD Patients with smoking history of 10 packs or more Patients who are taking or in need of tiotropium/olodaterol inhaler for the treatment of COPD Patients in a clinically stable state within 3 months of screening Patients who confirmed FEV1/FVC < 0.7 and FEV1 <80% after using bronchodilator Patients who confirmed FRC > 125% Patients who confirmed mMRC > 2  Exclusion Criteria:  Patients with a history of asthma Patients with asthma- COPD overlap Patients with serious disease other than COPD Patients with unstable or life-threatening cardiac arrhythmias Patients hospitalized for heart failure or myocardial infarction within 1 year of screening Patients with systolic ejection fraction less than 40% Patients with unstable ischemic heart disease Patients receiving regular oxygen therapy for 1hour or more per day Others who are difficult to participate in the research under judgment of the investigation