Inclusion Criteria:  Diagnosed with HCC according to the European Association for the Study of the Liver (EASL) diagnostic criteria TACE failure/refractoriness by Liver Cancer Study Group of Japan (LCSGJ) criteria Without extrahepatic metastasis The following laboratory parameters:  Platelet count ≥ 60,000/μL Hemoglobin ≥ 8.5 g/dL Total bilirubin ≤ 1.5 mg/dL Serum albumin ≥ 35 g/L ASL and AST ≤ 5 x upper limit of normal Serum creatinine ≤ 1.5 x upper limit of normal INR ≤ 1.5 or PT/APTT within normal limits Absolute neutrophil count (ANC) >1,500/mm3  Exclusion Criteria:  Known history of HIV History of organ allograft Patients with clinically significant gastrointestinal bleeding within 30 days prior to study entry. Serious non-healing wound, ulcer, or bone fracture Evidence of bleeding diathesis. Any other hemorrhage/bleeding event > CTCAE Grade 3 within 4 weeks of first dose of study drug