Inclusion Criteria:  Index cases  ≥18 years old Willing to provide the contact information of people who meet the definition of contacts, or willing to refer those people (which make require the distribution of study pamphlets) so that may contact study staff Willing to comply with study requirements i.e. provision of contact details and written, informed consent prior to enrolment Willing to provide sputa (expectorated or induced) for culture; and Meeting the definition for active TB.  Contacts (cohort)  ≥12 years old Meeting contact definition Able and willing to return for follow-up visits, with no plans to move soon Willing to comply with study requirements i.e. provision of contact details and written, informed consent or assent prior to enrolment Willing and able to provide sputum and blood Agree to potentially undergo CXR at M12 (women  Exclusion Criteria:  Index cases  No informed consent or assent More than six weeks has passed since the index case's first bacteriological result for TB was reported Patient was started on treatment based on empirical or clinical grounds (including CXR) alone Patient with rifampicin resistance (known from Xpert, Ultra, and/or MTBDRplus results)  Contacts (cohort)  No informed consent or assent Not diagnosed with active TB Unwilling or unable to provide blood More than six weeks has passed since reporting of the index case's first positive test result Has taken any form of TB treatment within the preceding two months (i.e., is currently on treatment). There are no exclusions based on any TB treatment more than two months prior.