Inclusion Criteria:  18 to 80 years of age; Acute ischemic stroke with National Institute of Health Stroke Scale (NIHSS) ≥ 10 and Volume of infarction on DWI <31ml or with a NIHSS ≥20 and 31ml<Volume of infarction<51ml(DWI); Patients who presented with acute ischemic stroke and a large vessel occlusion in the anterior circulation; Endovascular Therapy in 6-24 hours of stroke onset; The availability of informed consent.  Exclusion Criteria:  First ever stroke or mRS≤1 after previous disease; Hemorrhagic stroke: cerebral hemorrhage, subarachnoid hemorrhage; Coagulation disorders, systematic hemorrhagic tendency, thrombocytopenia Severe hepatic or renal dysfunction, increase in ALT or AST (more than 2 times of upper limit of normal value), increase in serum creatinine (more than 1.5 times of upper limit of normal value) or requiring dialysis; Severe cardiac or pulmonary disease; Patients with malignant tumor or under antineoplastic therapy with estimated lifetime less than 3 months; Pregnancy, plan to get pregnant or during lactation; Patients with contraindication or allergic to any ingredient of drugs in our study; Unsuitable for this clinical studies assessed by researcher