Inclusion Criteria:  Age of 18 years or older at registration. Diagnosis of cancer which is targeted by each cohort. Metastatic and/or recurrent disease.  Exclusion Criteria:  Any other malignancy within 3 years prior to registration, except for adequately treated basal cell or squamous cell skin cancer, or carcinoma in situ of the esophagus, stomach, colon, or cervix. Ongoing chemotherapy. (Chemotherapy-naïve patients or awaiting initiation of the next line of chemotherapy are eligible. There is no limit on the number of prior chemotherapies or on the time from completion of chemotherapy to registration). Ongoing radiation therapy. (There are no limits on the time from completion of radiation therapy to registration).