Inclusion Criteria:  Criteria for all groups:  Adults ≥ 18 years  Dated and signed inform consent *  * : written informed consent of relative (trusted person, close family) in case of emergency procedure, by default emergency inclusion notified in medical file and pursuance consent sought. Affiliation with a social security scheme  Criteria for control group:  Age-matched healthy donors  Criteria for chronic myeloid malignancies:  A diagnosis of low or high-risk myelodysplastic syndromes according to the WHO 2016 classification A diagnosis of dysplastic or proliferative chronic myelomonocytic leukemia according to WHO 2016  Criteria for COVID-19 patients:  Patients with a recent diagnosis (<7 days since first symptoms) of moderate or severe COVID-19  Exclusion Criteria:  Pregnant women Minor patient or major under protection Patients with COVID-19 infection and active cancer or a history of cancer within the last 6 months Patients with COVID-19 and severe comorbidities including cardiovascular or respiratory diseases, unbalanced diabetes, obesity (IMC >29) Patient on AME (state medical aid)