Inclusion Criteria:  Additional screening criteria check may apply for qualification:  ACR/European League Against Rheumatism (EULAR) criteria (2013) systemic sclerosis (SSc) diagnostic criteria satisfied. Skin thickening score based on the mRTSS between 10 and 22 inclusive.  Exclusion Criteria:  Additional screening criteria check may apply for qualification:  Pulmonary hypertension associated with SSc. Presence of a serious, SSc-related concurrent illness other than interstitial pneumonia. Finding of inadequate respiratory reserve capacity. Past history of rituximab, blinatumomab, obinutuzumab, or ofatumumab. Presence of a clinically significant active infection requiring antimicrobial therapy. A past history of cancer. Past history of a recurrent, clinically significant infection. Past history of severe allergy or anaphylactic reaction to a biologic drug product. Treatment with live vaccine within a certain period (inactivated vaccine is acceptable).