Inclusion Criteria:  Have provided written informed consent Be between the ages of 21 and 50 Be in good general health based on a physical examination, medical history, vital signs, and screening urine and blood tests Not be pregnant or nursing (if female). All females must have a negative serum pregnancy test at the screening visit and a negative urine pregnancy test at each study visit. Have a body mass index (BMI) in the range of 19 to 36 kg/m2 Blood pressure at Screening Visit does not exceed a systolic blood pressure (SBP) of 150 mmHg or a diastolic blood pressure (DBP) of 90 mmHg Have not donated blood in the prior 30 days. For women, consume ≥ 7 alcoholic drinks/week and for men, consume, ≥ 14 alcoholic drinks/week Report at least 1 day of binge drinking in the past 90 days (greater than 4 or 5 drinks on a single occasion for women and men, respectively) Report ≥ 5 uses of cannabis in the past year Provide negative urine test for illicit drug use (excluding THC) and negative breath alcohol test (0% BAC) at screening and before study sessions Report at least 1 instance of simultaneous alcohol and use in the past year.  Exclusion Criteria:  Psychoactive drug use (aside from cannabis, nicotine, alcohol, or caffeine) in past month Current use of over-the-counter (OTC) drugs, supplements/vitamins, or prescription medications that, in the opinion of the investigator or medical staff, will impact the participant's safety History of or current evidence of significant medical condition Evidence of current psychiatric condition [(MINI for Diagnostic and Statistical Manual (DSM)-V)] Meet criteria for severe alcohol use disorder (MINI for DSM-V) Clinical Institute Withdrawal Assessment for Alcohol scale (CIWA-Ar) score > 9 Been in treatment previously for alcohol or cannabis use disorder Use of cannabis, on average, more than 2 times/week over past 3 months Liver function tests more than 2x normal range Enrollment in another clinical trial or receiving of any drug as part of research within past 30 days Shipley vocabulary score <18 (corresponds to 5th grade reading level).