Inclusion Criteria:  age older than 40 years diagnosis of pituitary adenoma treatment-naïve with Endoscopic Endonasal Pituitary Surgery absence of other neurological diseases absence of vitreoretinal and vascular retinal diseases  Exclusion Criteria:  age younger than 40 years No diagnosis of pituitary adenoma previous treatments with Endoscopic Endonasal Pituitary Surgery presence of neurological diseases presence of vitreoretinal and vascular retinal diseases