Inclusion Criteria  Age ≥ 18 years and ≤ 70 years, male or female； Newly diagnosed multiple myeloma (NDMM) ； Transplant-eligible； Non-17p-, t(4;14) , t(14;16)； Expected survival ≥12 weeks; Eastern Cooperative Oncology Group (ECOG) scores 0 - 2.  Subjects should have adequate hemostatic and liver and kidney meet the following examination criteria: (without ongoing supportive treatments):  Complete blood count (CBC) results: absolute neutrophil count（ANC） ≥ 1.0 × 109/L, platelet count ≥ 75 × 109/L (if the proportion of plasma cells in the bone marrow is > 50%, subjects with platelets ≥ 50 × 109/L will be eligible), Hb ≥ 70 g/L. Blood biochemistry: creatinine clearance ≥ 30 mL/min, alanine aminotransferase (ALT) ≤ 2.5 × upper limit normal (ULN)，aspartate aminotransferase (AST) ≤ 2.5 × ULN, total bilirubin ≤ 1.5 × ULN. Serum calcium ≤14.0 mg/dL (≤3.5 mmol/L); Normal cardiopulmonary function; The patient agrees to join the clinical trial and signs an informed consent form.  Exclusion Criteria  Poor hypertension control; Have received ASCT or anti-tumor systemic therapy; Peripheral neuropathy or neuralgia of grade 2 or higher; During pregnancy or lactation or planning to become pregnant; History of other malignant tumors within 5 years; Subjects positive for any following tests: human immunodeficiency virus (HIV) antibody, Treponema pallidum (syphilis) antibody, hepatitis C virus (HCV) antibody, hepatitis B virus (HBV) surface antigen (HBsAg) and HBV DNA. Participating in other clinical trials; Allergic to the drugs in the treatment plan; Receiving any other experimental drugs or experimental medical devices; The investigator believes that the patient has other conditions that are not suitable for participating in this study.  Patients with R-ISS Phase III  -