Inclusion Criteria:  Female and male volunteers aged 21-50 Have used cannabis at least once Willing to provide written informed consent Willing to provide blood samples Fluent English speaker  Exclusion Criteria:  Past or present major mental illness Past or present major physical illness Past or present substance use disorder Past or present use of anti-psychotic or anti-depressant medications First degree relative with psychotic disorder Currently taking psychotropic medication Positive urine drug screen at screening or experimental visits Use of alcohol 24h prior to experimental visit or tobacco on the day of experiment Pregnancy (current or planned) or lactation in women Significant abnormality detected during physical examination at screening visit Cannabis use (defined as days in which cannabis is used recreationally) more than once per week on average over the last 12 months Any past use of synthetic cannabinoids Score of 5 and above on the Fagerstrom Nicotine dependence questionnaire BMI classified as obese or underweight Taken part in any drug study within the last 30 days or taking part in another study over the course of the trial Known drug sensitivity/allergy towards cannabis or Lorazepam