Inclusion Criteria:  Age > 18 years; Patients provides informed consent; Documented coronary artery disease: chronic coronary syndromes acute coronary syndromes presenting with at least one stenosis with indication for invasive functional assessment.  Exclusion Criteria:  Patients unable to provide informed consent; Pregnant women; Any contraindication to perform angiographic study or functional evaluation with pressure wire; Patients with aorto-ostial stenosis Target vessel diameter < 2mm