Inclusion Criteria:  Aged 18 and over who agreed to participate in the study, Cooperative and have no communication problem, Who have been on opioid therapy for at least 2 weeks, Can be fed orally, Constipation diagnosed by the physician, Patients whose constipation continues despite receiving laxative therapy for at least 1 week  Exclusion Criteria:  Diagnosed with a known psychiatric illness (delirium, anxiety, panic attack, depression) Have thrombocytopenia (thrombocyte count <50,000 / μL), Have a gastrointestinal tumor, Having a history of abdominal hernia, bowel cancer and abdominal surgery, Having intraabdominal infection, Have irritable bowel syndrome and intestinal obstruction, Patients with inflammatory bowel disease will be excluded.