Inclusion Criteria:  Definite diagnosis of inflammatory bowel disease【diagnostic criteria reference: (2020)JSGE Evidence-based clinical practice guidelines: inflammatory bowel disease】 There is no restriction on men and women, aged 18-65 years old; No complicated other serious diseases such as heart, brain, lung, liver, kidney, etc., no mental illness, and normal communication skills; No antibiotics, Bifidobacterium, Bacillus subtilis and other probiotic preparations have been used within one month; Sign the informed consent form and agree to participate in this research.  Exclusion Criteria:  Course of disease <6 months; Unspecified inflammatory bowel disease. Authors with bipolar disorder, persistent mood disorder, and mania; Patients with malignant tumors; Patients during pregnancy and lactation; Combined with hypertension, diabetes, heart disease, stroke or severe chronic disease (infectious, genetic, metabolic, internal Secretory diseases); Patients who cannot cooperate to complete the study.