Inclusion Criteria:  ≥18 years and ≤75 years in age AML diagnosed with ≥20% myeloid marrow blasts or peripheral blood blasts per WHO criteria(2008) at the time of initial diagnosis  For refractory AML, only cytarabine/daunorubicin(or Idarubicin) as can be applied repeatedly(maximal twice) as induction, no other chemotherapy are allowed to be applied Venatoclax /hypomethylation drug [HMA] can be used before and after chemotherapy.  For relapse AML, it must be the first or second relapse, and remain untreated. Certain regimens (Venatoclax/HMA, Venetoclax/LDAC, HMA single agent) and FLT3 inhibitors, tyrosine kinase inhibitors, IDH1/IDH2 inhibitors or similar targeted inhibitors used alone are not considered cytotoxic chemotherapy are allowed. No more than one prior stem cell transplant Has not received the chemotherapy regimen to be used for induction on this trial Is considered medically eligible to receive the chemotherapy regimen to be used for induction on this trial  Exclusion Criteria:  Patients with acute promyelocytic leukemia Acute leukemia of ambiguous lineage (biphenotypic leukemia) Chronic myeloid leukemia with myeloid blast crisis Active signs or symptoms of CNS involvement by malignancy (No lumbar puncture required) Prior use of G-CSF, CM-CSF or plerixafor within 7 days of dosing. Stem cell transplantation ≤4 months prior to dosing. Any immunotherapy or radiotherapy therapy within 28 days of dosing; any other experimental therapy or chemotherapy within 14 days of dosing Inadequate organ function. Abnormal liver function. Known active infection with hepatitis A, B, or C, or human immunodeficiency virus. Moderate kidney dysfunction (glomerular filtration rate <45 mL/min). Uncontrolled acute life-threatening bacterial, viral, or fungal infection. Clinically significant cardiovascular disease. Major surgery within 4 weeks of dosing.