Inclusion Criteria:  Meet the diagnostic criteria for endometriosis and have dysmenorrhea VAS score ≥4 points; Age 18 to 45; Regular menstrual cycle (28±7 days); Not pregnant at the time of seeing a doctor and no pregnancy plan during the medication, can insist on contraception; No pelvic nodules or adnexal masses, or pelvic nodules or adnexal masses ≤4cm; CA125 is normal or slightly elevated (below 200U/ml). Patients who voluntarily signed the informed consent and had conditional follow-up.  Exclusion Criteria:  Patients who have known to have malignancies of reproductive organs or other malignancies; Suffering from serious diseases or mental diseases such as cardiovascular, cerebrovascular, liver, kidney or hematopoietic system; Uterine fibroids (≥3cm) and adenomyosis (uterine over 6 weeks of gestation, the reference value of uterine tridiameter at 6 weeks is 12cm, 7.5cm, 4.5cm); Those who received hormone drug therapy within 3 months before enrollment; lactating patients.