Inclusion Criteria:  A confirmed severe form of any type of pyoderma with lesions of the skin and muscle tissue was diagnosed Male or female, age ≥ 21 years Previous treatment with TNF antagonists (infliximab, adalimumab, etanercept, certolizumab, golimumab) ended no earlier than 30 days before starting therapy Secondary treatment failure with up to one previous TNFα antagonist treatment (from the list above) Secondary failure of corticosteroid treatment Adequate hematologic, hepatic, and renal function Written informed consent.  Exclusion Criteria:  History of primary resistance or intolerance to any TNFα antagonist. History of congestive heart failure or current, controlled or uncontrolled Women who are pregnant or breastfeeding, or women of childbearing age if no effective method of contraception has been used during and for 3 months after the trial Men, if no effective contraceptive method was used during the study and for 3 months afterward Any prior exposure to Hu5F9-G4 or other CD47 targeting agents Previous allogeneic stem cell transplant within 6 months prior to enrollment, active graft versus host disease (GVHD), or need for graft-associated immunosuppression Refusal to sign the informed consent