Inclusion Criteria:  Suspected or documented infection Organ dysfunction defined as SOFA score ≥2 Need for vasopressor infusion for ≥2 hours Serum lactate ≥2 mmol/L Eligible for critical care admission without any restrictions  Exclusion Criteria:  >24 hours since the time point of meeting all inclusion criteria <18 years of age Pregnancy Patients with a known allergy to albumin Jehova's witnesses or other patients expressing a known objection to the use of blood products Previous receipt of human albumin solution for the episode of sepsis in question Previous enrolment in this study