Inclusion Criteria:  >18 years of age For patients with choledocholithiasis found by MRCP and feasible ERCP lithotomy, the diameter of calculi ≥1cm should be indicated (number of calculi should be indicated >5 or<5) During ERCP, the surgeon determined that the calculi should be removed by combining EPBD and mechanical lithotripsy, and the calculi could be removed by a single ERCP Previous cholecystectomy or planned recent cholecystectomy or liver lobectomy can also be included Subjects voluntarily participate in this study and sign the informed consent  Exclusion Criteria:  Coagulation disorders (INR>1.3) and peripheral blood plate count significantly decreased<50x10^9/L Preoperative complicated with acute pancreatitis Preoperative biliary hemorrhage Complicated with severe liver disease and primary sclerosing cholangitis Mirizzi syndrome and intrahepatic bile duct stones Complicated malignant tumor of hepatobiliary and pancreatic system Complicated with obvious stricture of the lower segment of the bile duct intraoperative bile duct duodenal fistula was found Previous EST or EPBD Previous history of gastrointestinal reconstruction surgery 11. Other ERCP contraindications