Inclusion Criteria:  Currently receiving haemodialysis, or peritoneal dialysis that can be converted to haemodialysis, with planned ongoing haemodialysis a minimum of three times per week for at least the duration of the protocolised calciphylaxis treatments within this trial Have a new calciphylaxis ulcer present for less than 10 weeks Age ≥ 18 years Eligible for randomisation in at least one recruiting domain The participant and treating physician are willing and able to perform trial procedures  Exclusion Criteria:  Nil