Inclusion Criteria:  Male or females 18-75 years old. Subjects diagnosed with moderate-to-severe allergic asthma [Global Initiative for Asthma [GINA]; GINA, 2019) at least 12 months prior to Visit 1 and post-bronchodilator (BD) reversibility of FEV1 ≥ 12% and ≥ 200 mL during screening. Documented reversibility from historical data within 5 years of Visit 1 of at least 12% and 200 mL in FEV1 after the administration of 200 to 400 mcg albuterol/salbutamol (2 to 4 inhalations of albuterol/salbutamol or of a nebulized solution of albuterol/salbutamol, if considered as a standard office practice) OR documented airway hyperresponsiveness (methacholine provocative concentration (PC)20 < 8 mg/mL [or PC20 < 16 mg/mL on ICS]) within 5 years of Visit 1. Reversibility should be documented. If reversibility data is not available, the bronchodilator test should be finished before randomization. Subjects must have a morning pre-bronchodilator FEV1 value of ≥ 40% and ≤ 80% predicted at screening  Subjects must have received a physician-prescribed asthma regimen with medium- or high-dose ICS plus LABA for at least 3 month prior to Visit 1 and the dose of ICS must be stable for at least 30 days prior to Visit 1 and throughout the screening period.  High-dose ICS is defined as total daily dose of >500 mcg fluticasone propionate or equivalent Medium-dose ICS is defined as a total daily dose of 250 to 500 mcg fluticasone propionate or equivalent. Equivalence ICS doses will be based upon the GINA guidelines (GINA, 2019), shown in Appendix 12.1 According to the medical history, subject have no more than a maximum of 2000 mcg/day equipotent ICS daily dosage of fluticasone propionate or equivalent in 3 months before entry of study.  Prior to screening, subjects must be on a stable dose of any of the following doses and formulations of ICS/LABA combination therapy for at least 1 month:  Fluticasone/salmeterol combination therapy  Advair® Diskus - dry powder inhaler (DPI): 250/50 μg BID or 500/50 μg BID, or Advair® HFA - metered dose inhaler (MDI): 230/42 μg BID or 460/42 μg BID, or Budesonide/formoterol combination therapy (Symbicort® -160/9 μg BID or 320/9 μg BID), or Mometasone/formoterol combination therapy (Dulera® -200/10 μg BID or 400/10 μg BID). Subjects must have a documented history of protocol-defined severe asthma exacerbation at least 1 or more times within the 12 months. A total serum IgE ≥ 400 IU/mL. Subjects must have at least one positive in skin prick test or at least one environmental allergen-specific IgE greater than normal range. Uncontrolled asthma demonstrated both during the screening period and at the time of randomization defined as ACQ-5 (5-item Asthma Control Questionnaire) ≥ 1.5 If recently treated for respiratory tract infection, the treatment must have been completed at least 4 weeks prior to screening. Subjects who have an upper respiratory tract infection during screening are allowed to be rescreened 4 weeks after resolution.  Female subjects of childbearing potential must use at least two forms of birth control. One must be barrier protection (i.e., condom or female condom) and the other is one of acceptable method of birth control (ie, diaphragm, intrauterine device, hormonal contraceptives, or abstinence) throughout the study. Subjects who are surgically sterile (ie, hysterectomy, bilateral tubal ligation, or bilateral oophorectomy), or postmenopausal (defined as amenorrhea for 12 consecutive months and documented serum follicle stimulating hormone level >40 mU/mL) will be considered as no childbearing potential. All female subjects of child-bearing potential must have a negative serum pregnancy test at screening.  Note: The subject must use the methods of contraception mentioned above during study period and at least 120 days after the last dosing of FB825.  The subject has a body weight ≥ 40 kg at screening. The subject has a normal, as determined by the investigator, 12-lead electrocardiogram (ECG). The subject is able to provide written informed consent. The subject agrees to comply with all protocol requirements.  Exclusion Criteria:  Asthma exacerbation or any other reason requiring systemic steroids in the 30 days prior to randomization. Subjects are allowed to be rescreened 30 days after completion of treatment. >20% relative change in FEV1 between screening and randomization. Female subjects who are pregnant or lactating. A positive human immunodeficiency virus (HIV) test (e.g., HIV Ag/Ab combo test) at screening or subject taking antiretroviral medications, as determined by medical history. Patients with positive HBeAg results should be excluded as it is an indication of active Hepatitis B virus replication. Active lung diseases (e.g., bronchitis, chronic obstructive pulmonary disease) other than allergic asthma. Use of any experimental drug within 30 days or 5 half-lives, whichever is longer, prior to or during the screening period. Current or history of treatment with a monoclonal antibody, for example, interleukin (IL)-4, IL-5, IL-13 or IL-15 antibody treatment within 6 months prior to the screening. Current or history of treatment with anti-IgE antibody treatment within 6 months or 5 half-lives, whichever is longer. The subject has a history of alcohol or drug abuse that would impair or risk the patients' full participation in the study, in the opinion of the investigator. The subject has any condition that, in the opinion of the investigator, would compromise the study or the well-being of the subject or prevent the subject from meeting or performing study requirements. The subject has indication of severe liver disease, defined by serum levels of either alanine aminotransferase (ALT), aspartate transaminase (AST) above 3x upper limits of normal (ULN) or elevated total bilirubin >2x ULN as determined at screening. The subject has severe kidney disease, defined as estimated glomerular filtration rate (GFR)<30ml/min/1.73m2 or creatinine > 3x ULN. The subject has known or suspected history of immunosuppression or immunodeficiency. Known history of active tuberculosis (TB) or evidence of tuberculosis infection as defined by a positive purified protein derivative (PPD) skin test and/or interferon-gamma release assay. The interferon-gamma release assay should be repeated in case of an indeterminate result. The subject has history of malignancy within 5 years before the screening period. Patients with non-invasive carcinoma in-situ of the cervix, basal cell carcinoma or squamous cell carcinoma of the skin may be eligible if they have undergone curative resection at least 12 months prior to screening. Current smoker with > 10 packs year prior to screening. A smoker is defined as a subject who has taken inhaled nicotine containing products (e.g. cigarette, cigar, pipe), including e-cigarettes prior to screening.  High risk of parasite infection  • Risk factors for parasitic disease (living in an endemic area, travel within the last 6 months to regions where geohelminthic infections are endemic, and/or chronic immunosuppression).  AND  • Evidence of parasitic colonization or infection on stool evaluation for ova and parasites.  Note: stool ova and parasite evaluation will only be conducted in patients with risk factors and an eosinophil count more than twice the upper limit of normal.  The subject has received live vaccine within 12 weeks prior to dosing or planned live attenuated vaccinations during the study. The subject has a history of any clinically relevant arrhythmias as determined by the investigator. The subject has a history of respiratory failure or near fatal asthma events which resulted in intensive care unit admission or intubation within five years before the screening period. History of anaphylaxis to any biologic therapy. The subject has major surgery, for example organ replacement, joint replacement, full hysterectomy, heart surgeries, within 8 weeks before the screening. The subject who has major surgery prior to 8 weeks of screening should have fully recovered from any surgical procedures. The subject has comorbid disease that might interfere with the evaluation of IMP (investigational medicinal product) or conduct of study procedures (eg, bronchodilator test). The subject requiring non-selective beta-adrenergic receptor blockers for any reason and initiation or dose change of a selective beta-1 adrenergic receptor blocker within 3 months prior to Visit 1. The subject who received bronchial thermoplasty within 3 years of Visit 1 OR patients who plan to begin therapy during the Screening Period or the Randomized Treatment Period. The subject with active autoimmune disease (excluding atopic dermatitis) or patients using immunosuppressive therapy for autoimmune disease (excluding atopic dermatitis) (eg, rheumatoid arthritis, inflammatory bowel disease, primary biliary cirrhosis, systemic lupus erythematosus, multiple sclerosis, etc.) or patients with high titer autoantibodies at screening who are suspected of having high risk for developing autoimmune disease at the discretion of the Investigator or the Sponsor. Use of Traditional Chinese Medications in the treatment of asthma within 3 months prior to screening. (To be listed in Prohibited Medications) Aggravating factors that are inadequately controlled e.g., medication uncontrolled gastroesophageal reflux disease. The subject has adrenal insufficiency (ACTH-resistant) by rapid ACTH stimulation test due to known history of adrenal insufficiency or being suspected of adrenal insufficiency or long-term use of systemic corticosteroids (annual average more than 6 months in the past two years).  Adrenal insufficiency: after 30 minutes of ACTH injection, the cortisol level ≦20 mg/ml in rapid ACTH stimulation test.