Inclusion Criteria:  Age ≥ 70 years old; ASA: Grade Ⅰ～Ⅳ; Signed informed consent； Scheduled non-cardiac surgery.  Exclusion Criteria:  Refuse to participate; Expected length of stay <3 days; The same patient can only be included once, regardless of whether the reason for the second operation is related to the first cause; Emergency surgery patients; Inability to communicate due to illiteracy, language impairment, severe hearing or visual impairment; Central nervous system diseases, including various types of dementia and depression Severe renal insufficiency (requiring dialysis treatment); Severe liver dysfunction (Child-Pugh score ≥10); Patients who have participated in other relevant clinical studies within 3 months MMSE examination has confirmed the existence of cognitive dysfunction: illiteracy ≤17 points, primary school degree ≤20 points, middle school degree (including technical secondary school) ≤22 points, university degree (including junior college) ≤23 points