Inclusion Criteria:  aged≥20 years with a single clinically or histologically diagnosed colorectal lesions of 20-50mm eligible for which fulfilled criteria for ESD;  Exclusion Criteria:  Patients with coagulopathy (platelet count < 5 × 10*4, prothrombin time international normalized ratio > 2, medical conditions requiring the continuous use of antithrombotic agents prior abdominal surgery or radiation.