Inclusion Criteria:  Subject aged ≥ 18 to ≤ 65 years old Meet ICD-10 criteria for a primary diagnosis of schizophrenia， the duration must be at least one year Provide written informed consent (subject's legal guardian or impartial witness shall sign informed consent if the subject is unable to sign) and is willing and able to comply with the protocol in the opinion of the investigator. Considered to be an appropriate candidate for switching olanzapine due to safety or tolerability concerns Received Olanzapine monotherapy at a dose of 10 to 20mg/d for at least 8 weeks with a body mass index (BMI) ≥25kg/m2, the dose of olanzapine has been stable for at least 4 weeks prior to screening. Weight gain during current olanzapine therapy was verified in the subject history.  Subject must meet the clinical stability as following criteria:  CGI-S ≤ 4 (at both Screening and Baseline) PANSS total score ≤ 70 at Screening and Baseline No exacerbation of schizophrenia has occurred for at least 8 weeks prior to screening  Exclusion Criteria:  Subjects with severe or unstable physical diseases (including but not limited to severe or unstable cardiovascular diseases, cerebrovascular diseases, liver and kidney diseases) determined by the investigators. Currently has severe liver function impairment, or serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) level ≥3 times the upper limit of normal value Creatinine clearance rate < 50mL/min Subjects had a history of stomach or intestinal surgery or any other condition that could interfere with absorption, distribution, metabolism, or excretion of medications More than 10% weight loss 3 months prior to the screening period A history of malignant tumors (including benign pituitary tumors) Any chronic organic disease of the central nervous system (excluding schizophrenia), such as CNS related tumors and inflammation, active seizures, vascular disease, Parkinson's disease, Alzheimer's disease, or other forms of dementia, myasthenia gravis, and other degenerative diseases. A history of mental retardation or persistent neurological symptoms caused by severe head injury Subjects need to take any potent CYP3A4 inhibitor (e.g., ketoconazole, ritonavir, clarithromycin, ritonavir, voriconazole, Mibefradil) or inducer (e.g. rifampicin, avasimibe, St. John's Wort, phenytoin, carbamazepine), drugs for external use in dermatological patients are excluded Subject has a history of treatment with clozapine for refractory psychosis and/or subject has been treated with clozapine (for any reason) within 4 months of baseline Subjects has used long-term antipsychotic drugs in the following time prior to the enrolment Subjects received electroconvulsive therapy (ECT) within 90 days prior to screening, or were expected to require ECT during the study A history of neuroleptic malignant syndrome Severe tardive dyskinesia, severe dystonia, or any other severe dyskinesia Subjects is at risk of suicide or self-mutilation behaviours or the act of endangering others, or other corresponding characteristic behaviour, or a history of suicide Female subjects were pregnant (positive pregnancy test at screening) or breast-feeding or planning pregnancy for the duration of the study, or the partners of male subjects were planning pregnancy for the duration of the study History of severe allergy or hypersensitivity; Angioedema occurred after previous administration of lurasidone; Patients who had previously participated in a clinical study of lurasidone; The subject is participating in or has participated in other clinical trials, including the use of commercially available drugs or medical devices, within 30 days prior to the signing of the informed consent; Any other conditions judged by the investigators that not suitable to participate in this study