Inclusion Criteria:  Healthy women in the age of 30-65  Able to follow the following dietary restriction for 4 months (4 weeks wash-out, 3 months intervention):  Do not take omega-3 supplements do not take supplements containing vitamin A do not take supplements containing collagen try to avoid using skin products containing vitamin A do not undergo skin treatment  Exclusion Criteria:  Pregnancy or breast feeding known allergy to seafood skin treatment the last 6 months planned skin treatment during the study period  -