Inclusion Criteria:  Age 18-80 years;  Histologically proven colorectal carcinoma (TNM stage I-IV)  R0 resection is possible according to preoperative evaluation  Written informed consent for participation in the trial.  Exclusion Criteria:  Primary tumor or metastases not able to be removed radically  Receiving any preoperative treatment (Including chemotherapy, radiotherapy and target therapy)  Have other malignant tumors meanwhile  Other previous malignancy within 5 years