Inclusion Criteria:  men or women aged 18 years and older at Visit 1 (Baseline/Screening) women of child-bearing potential must have a negative urine pregnancy test at Visit 1 (Baseline/Screening) must be confirmed positive for SARS-CoV-2 with RT-PCR testing of a nasal swab taken within 72 hours prior to randomization (first dose of study drug) must have a score ≤ 2 on the WHO ordinal scale for clinical improvement subject must be willing to refrain from any other intranasal instillations (e.g., medications, saline, etc.) for 24 hours after study medication dosing must be capable, in the opinion of the investigator, of providing informed consent to participate in the study.  Exclusion Criteria:  women who are pregnant or lactating hospitalized subjects or subjects requiring nursing care for COVID-19  currently has one of the clinical signs suggestive of moderate-to-severe COVID-19 illness:  O2 saturation of ≤ 93% on room air at sea level Heart rate ≥ 90 beats per minute (after seated for 5 min) Respiratory rate ≥ 20 breaths per minute receiving respiratory support (including any form of oxygen therapy) history of hypothyroidism, goiter, hyperthyroidism, thyroid tumor, autoimmune thyroid disease currently taking medications that contain iodine or currently taking lithium receiving any other investigational drug has an allergy, hypersensitivity, or contraindication to povidone iodine has an allergy or hypersensitivity to any excipients in study medication any serious or unstable concurrent disease, psychiatric disorder, or any significant condition that, in the opinion of the investigator could confound the results of the study or could interfere with the subject's participation or compliance in the study