Inclusion Criteria:  Any patients above 40 years with type 2 diabetes of at least two years duration complicated with diabetic nephropathy.  Exclusion Criteria:  Patients below 40 yrs. Patients with type 1 diabetes complicated with diabetic nephropathy Type2 diabetes without nephropathy. Diabetic nephropathy cases on dialysis due to other causes Blood pressure more than 160/100 Acute coronary syndrome in the past 6 months Non alcoholic fatty liver disease, impaired liver function. Malignancy. Pregnancy Acute infection, acute inflammation. Severe renal impairment, and urinary tract infection.