Inclusion Criteria:  Patient must between 18 and 75 years old, male or non-pregnant female. Patient must have evidence of myocardial ischemia (e.g., stable, unstable angina, silent myocardial ischemia, or acute myocardial infarction> 1 week) suitable for elective PCI.  One or two de novo target lesions each located in a different epicardial vessel.  If there is one target lesion, another non-target lesion may be treated but the non-target lesion must be present in a different epicardial vessel, and must be treated first with a successful result prior to randomization of the target lesion. If two target lesions are present, they must be present in different epicardial vessels and both satisfy the angiographic eligibility criteria. The definition of epicardial vessels means the left anterior descending artery (LAD), the left circumflex artery (LCX), and the right coronary artery (RCA) and their branches. Thus, for example, the subject must not have lesions requiring treatment in both the LAD and a diagonal branch. Lesion(s) must have a visually estimated length of ≤33mm, diameter between range of 2.5-4.0mm, and each lesion can be completely covered by a stent. Lesion(s) must have a visually estimated diameter stenosis of ≥70% (or ≥50% and have evidence of myocardial ischemia in this location) with a TIMI flow of ≥1 Patient can understand the study purpose, voluntarily participate in the study, sign the informed consent, and willing to undergo 5-year follow-ups.  Exclusion Criteria:  General Exclusion Criteria  Patient had an acute myocardial infarction (AMI) or CK, CK-MB have not returned to within normal limits after myocardial infarction within 7 days of the index procedure. Patient has implanted stent in the target vessel within 1 year of the index procedure, or is scheduled to undergo re-intervention in the future 6 months. Patient with a history of coronary artery bypass (coronary artery bypass grafting). Patient with contraindications on coronary artery bypass graft surgery. Patient with severe heart failure (NYHA class ≥III) or left ventricular ejection fraction<40% (by echocardiography or contrast left ventriculography). Patient with known renal insufficiency: serum creatinine > 2.0 mg/dl or 177 μmol/L, or/and patient on dialysis. Patient with known hepatic insufficiency: ALT, AST ≥3 times the upper limit of normal. Patient had an ischemic stroke within 6 months or transient ischemic neurological attack (TIA) within 3 months before the index procedure, or has tendency of hypercoagulation as per investigator judgement or laboratory test. Patient with bleeding diathesis, active gastrointestinal ulcers, history of cerebral hemorrhage or subarachnoid hemorrhage, contraindications on antiplatelet agents and anticoagulant therapy, and unable to undergoing antithrombotic therapy. Patient with known allergy to aspirin, clopidogrel, heparin, contrast agent, PDLLA, sirolimus and metal (iron, zinc etc). Patient with a history of disease related to iron overload or iron disorder, such as hereditary hemochromatosis, etc. Patient with life expectancy ≤1 years. Patient is already participating in another drug or medical device clinical trial that has not yet reached its primary endpoint. Patient with poor compliance and cannot comply with the protocol requirement as per investigator judgement. Subject has received a heart transplant. Patient with unstable arrhythmia, such as high-risk ventricular premature beat and ventricular tachycardia. Patient requires chemotherapy for malignancy. Patient with known immunosuppressive or autoimmune disease, and is receiving or scheduled to receive immunosuppressant therapy. Patient is receiving or scheduled to receive chronic anticoagulation therapy such as aspirin and warfarin, etc. Patient is scheduled to receive a surgery that require to stop antiplatelet drugs such as aspirin and clopidogrel. Patient has a platelet count <100x109/L or >700 x109/L, a white blood cell count of <3 x109/L during the screening period. Patient with diffuse peripheral vascular disease, and cannot use 6F catheter. Patient with prior valvular surgery.  Angiographic exclusion criteria  Chronic total occlusion (TIMI flow of 0 before the index procedure). Target lesion is located in left main. Aorto-ostial target lesion (within 3 mm of the ostium). Target lesion involving a bifurcation lesion with side branch ≥2.5 mm in diameter (the ostium of side branch has restenosis ≥40% or require balloon pre-dilatation). Visible thrombus in target vessels. Severe triple vessels lesions and all require revascularization.  Severe calcified or distorted lesions which unable to predilate, not suitable for stent delivery and expansion, impair delivery including:  Extreme angulation (≥ 90°) proximal to or within the target lesion Excessive tortuosity (≥ two 45° angles) proximal to or within the target lesion Moderate or heavy calcification proximal to or within the target lesion In-stent restenosis target lesion. Target lesion involves a myocardial bridge. The investigational stent would need to cross the previously implanted stent to reach the target lesion.  Target lesion which prevents complete balloon pre-dilatation, defined as full balloon expansion with the following outcomes:  Residual diameter stenosis (DS%) is < 40% (per visual estimation), ≤ 20% is strongly recommended. TIMI flow of 3 (per visual estimation). No angiographic complications (e.g., distal embolization, side branch closure). No dissections National Heart, Lung, and Blood Institute (NHLBI) grade D-F. No chest pain lasting > 5 minutes. No ST depression or elevation lasting > 5 minutes.