Inclusion Criteria:  Paitent who aged over 20, with clear consciousness, is capable of communicating with Chinese, and is able to perform ear acupoints by himself/herself. Pancreatic Cancer patients who receives chemotherapy at outpatient department. The subject who agrees and is willing to participate in the research after explaining the purpose of the research.  Exclusion Criteria:  Patient who is younger than 20 years old, illiterate, or is unable to cooperate with intervention measures. Patient who is not suitable for ear acupoint pressing after evaluated by the attending physician.