Inclusion Criteria:  Solid pancreatic lesions 3 1cm Peri-GI tract lymph nodes 3 1cm Peri-GI tract masses Lesions of the GI wall Signed informed consent  Exclusion Criteria:  Pancreatic cystic lesions (more than 50% of the volume) Diameter of lesion ≤ 1 cm Lesion not seen at EUS Pregnancy Coagulopathy (platelet count <50.000/mm3 and/or international normalized ratio >1.5); Severe cardiorespiratory dysfunction precluding endoscopy; Failure to provide informed consent