- Female  Inclusion criteria:  In pre-menopausal period Aged between 18 to 40 years Patients that meet the classification criteria according to Systemic Lupus International Collaborating Clinics classification criteria (SLICC) Patients with SLEDAI score ≤ 4 on Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) Under glucocorticoid treatment at a dosage <10 mg/day Under treatment with chloroquine at a stable dose  Exclusion Criteria:  Infection Diabetes Smokers Pregnancy