Inclusion criteria  The inclusion criteria are healthy female subjects who/with:  have read the subject information and signed informed consent documents age 18 - 55 years body mass index between 18-25 kg/m2 have a normal electrocardiogram blood pressure within normal range (90-120 mmHg for systolic blood pressure and 60-80 mmHg for diastolic blood pressure) heart rate within normal range (60-100 bpm) with absence of significant disease or clinically significant abnormal laboratory values on laboratory evaluation, medical history or physical examination during screening pass hormone screening related to cyproterone acetate and ethinyl estradiol  Exclusion criteria  Any of the following criteria will exclude the subject from the study:  those who are pregnant and/or nursing woman. those with history of hypersensitivity to cyproterone acetate and ethinyl estradiol or other oral contraception or other ingredients in the drugs or a history of serious allergic reaction to any drug, significant allergic disease, allergic reaction, or active allergic. those with a history or presence medical condition which might significantly influence the pharmacokinetic of the study drug, e.g. chronic gastrointestinal disease, diarrhea, gastric surgery, renal insufficiency, hepatic dysfunction or cardiovascular disease. those with a history or presence of any coagulation disorder or clinically significant hematology abnormalities, thrombophlebitis, and thromboembolic disorder. those who are using any medication (prescription or non-prescription drug, food supplement, herbal medicine, oral contraception, anti-platelet drug), particularly the medication known to affect the pharmacokinetic of the study drug, within one week prior to the drug administration day. those who have participated in any clinical study within 3 months prior to the study (< 90 days). those who have donated or lost 300 ml (or more) of blood within 3 months prior to the study. those who smoke. those who are positive to HIV, HBsAg, and HCV tests (to be kept confidential). those with a history of drug or alcohol abuse within 12 months prior to screening for this study. those who are unlikely to comply with the protocol, e.g uncooperative attitude, inability to return for follow up visits, poor venous access.