Inclusion Criteria  Men and women 18 years and older at the time of signing the Informed Consent Form. Availability of written informed consent signed by the patient prior to the start of any procedures related to the study.  Confirmed diagnosis of HAE:  C4 level <50% of the lower limit of the range of normal laboratory values and one of the points below: the C1INH level <50% of the lower limit of the range of normal laboratory values, OR the level of C1INH within normal values, while the level of functional activity of C1INH is below 50% of the lower limit of the range of normal values. Localization of the edema in the abdominal cavity, in the face area (lips, eyelids, subcutaneous tissue), limbs, trunk or in the area of the external genitals in the anamnesis. ≥4 HAE attacks requiring treatment or causing significant functional impairment for 2 consecutive months in the 3-month period prior to Screening, properly documented in the medical records. Patient's consent to adhere to reliable methods of contraception.  Exclusion Criteria  Deviation of the C1q level below the normal limit. B-cell lymphoproliferative diseases in the anamnesis or at the time of inclusion in clinical trial. The presence of anti-C1INH autoantibodies. Allergic reactions to the components of C1INH drugs or other blood components. Glomerular filtration rate ≤59 ml/min/1.73 m2, calculated by the formula CKD-EPI Creatinine Equation (2009) (see Appendix). The concentration of peripheral blood leukocytes >20*109/L. Drug addiction, solvent abuse, alcoholism in the anamnesis or at the time of inclusion. Participation in clinical trials of C1-esterase inhibitor drugs, blood transfusion and its components during the last 90 days prior to screening. Participation in clinical trials of any other investigational drugs within the last 30 (thirty) days prior to screening. Positive laboratory results for HIV and hepatitis B and C. Pregnancy and lactation. Diseases and conditions associated with thrombosis (myocardial infarction, transient ischemic attacks, deep and superficial vein thrombosis, and pulmonary embolism) less than 6 months before the start of the screening period, as well as an increased risk of arterial or venous thrombosis according to the study doctor's opinion.  Concomitant diseases and conditions that according to the study doctor's opinion put the patient's safety at risk when participating in the study, or that will affect the analysis of safety data if this disease/condition worsens during the study, including:  Mental illness; Diseases of the immune and endocrine system that are not controlled by drug therapy (including decompensated diabetes mellitus and thyroid diseases); Hematological diseases requiring chemotherapy; Cancer or cancer in the past medical history, with the exception of cured basal cell carcinoma; Decompensated liver diseases.