Inclusion Criteria:  Advanced hepatocellular carcinoma with an indication of systemic therapy by Atezolizumab-Bevacizumab At least one measurable untreated lesion ECOS performance status of 0 or 1  Exclusion Criteria:  HIV/ immunosuppressive treatment Active of history of autoimmune disease or immune deficiency Priori history of liver transplantation or systemic porto shunt Pregnant of breastfeeding women