Inclusion Criteria:  Telephone Interview of Cognitive Status (TICS-M) performance above impaired range (≥21)  Group-specific criteria:  First time, primary diagnosis of prostate cancer (ADT+ and ADT-) Diagnosed within past 30 days (ADT-) Scheduled to receive ≥ 6-months androgen deprivation therapy and have not received >30 days of androgen deprivation therapy (ADT+) Men without a history of cancer who are within one year of age of ADT+ participants (PCa-)  Exclusion Criteria:  Second cancer diagnosis (excluding non-invasive skin cancers) History of stroke, transient ischemic attack, neurological disorder, or brain surgery involving tissue removal Unable to walk without assistance Unwilling to complete study requirements Body weight greater than 300 pounds (DXA requirement) Moderate-intensity physical activity ≥ 150 minutes per week Upper and lower body strength training ≥ 2 days per week Unable to read in English