Inclusion Criteria:  ①Healthy volunteers or VCIND patients（Diagnostic criteria comply with the "Guidelines for the Diagnosis and Treatment of Vascular Cognitive Impairment" formulated by the Dementia and Cognitive Impairment Group of the Neurology Branch of the Chinese Medical Association）; ②Age between 50-70 years old; ③Able to accept and cooperate in completing various instrumental examinations and neuropsychological examinations Scale testing; ④Agree to sign an informed consent form.  Exclusion Criteria:  ①Combined with other serious diseases, life expectancy is less than 3 years; ②Patients with vision and hearing impairment that significantly affect cognitive testing; ③Severe heart, brain, lung, kidney and other diseases; ④Have a history of psychoactive substance abuse; ⑤Have other serious physical diseases that affect cognitive testing, such as coma, epilepsy, hypothyroidism , Hypoxemia, etc.; ⑥have a history of mental illness; ⑦have MRI contraindications, unwilling to participate in research and unconditional follow-up.