Inclusion Criteria:  Major patient; Patient affiliated to a social security scheme; Patient suffering from Chronic Myeloid Leukemia, taking a Tyrosine Kinase Inhibitor (Imatinib, Nilotinib, Dasatinib, or Bosutinib); Molecular response < 4,5 Log;  Exclusion Criteria:  Legal incapacity or limited capacity ; Medical or psychological incapacity or limited capacity; Not able to read and/or to write French; Patient taking Ponatinib.