Inclusion Criteria (primary outcome measure):  - Post-menopausal women  Inclusion Criteria (secondary outcome measure):  Women currently experiencing, or have experienced in the last month, moderate to severe VMS symptoms (i.e. minimum of 1 moderate to severe hot flushes per day over the last month) Peri-menopausal and post-menopausal women  Exclusion Criteria (primary outcome measure):  Women with current breast cancer treatment Women treated with anti-estrogens, aromatase inhibitors or Gonadotropin-releasing hormone (GnRH) agonists/antagonists for cancer or any other medical condition.  Additional exclusion criterion for secondary outcome measures will be:  - Mild VMS symptoms only