Inclusion Criteria:  Male and female subjects, 17-65 years of age Provide voluntary, written informed consent (parent(s) / legal guardian(s) of participant); provide voluntary, written assent (participants, as appropriate) PWS due to chromosome 15 micro-deletion, maternal uniparental disomy, or imprinting defect, confirmed by fluorescent in situ hybridization, chromosomal microarray, and/or methylation studies Body weight of at least 50 kg with BMI ≥27 kg/m² A HQ-CT score >10  If a subject has a diagnosis of type 2 diabetes, the following criteria must be met:  Hemoglobin A1c (HbA1c) <7.5% not being managed with insulin. Patients taking glucagon-like peptide (GLP)-1 analogues (exenatide or liraglutide) must have been on stable dose for greater than 3 months. Fasting plasma glucose <140 mg/dL during the Screening Period No history of ketoacidosis or hyperosmolar coma  Stable or well-controlled blood pressure (BP) and vital signs. Specifically: Vital signs after 5 minutes resting in seated position (feet flat on floor, back supported):  95 mmHg <systolic blood pressure (SBP) <160 mmHg 45 mmHg <diastolic blood pressure (DBP) <100 mmHg 40 bpm <heart rate (HR) <100 bpm Stable body weight for ~2 months (self or guardian-reported loss/gain within ± 10%) prior to enrollment Standard 12-lead ECG parameters after 10 minutes resting in supine position in the following ranges; 120 ms <PR <220 ms, QRS <120 ms, QTc ≤430 ms if male, ≤450 ms if female and normal ECG tracing unless the Investigator considers an ECG abnormality to be not clinically relevant. Parent or guardian is able to communicate well with the investigator, to understand and comply with the requirements of the study, and be able to understand and sign the written informed consent. Assent is to be provided for the patient who cannot consent for himself or herself Results of screening clinical laboratory tests [complete blood count (CBC) with differential and platelets and chemistry profile] and vital signs must be within normal range or, if outside of the normal range, must be accepted by the investigator and sponsor as not clinically significant Females of non-childbearing potential, defined as surgically sterile (status post hysterectomy, bilateral oophorectomy, or bilateral tubal ligation) or post-menopausal for at least 12 months (and confirmed with a screening FSH level in the post-menopausal lab range), do not require contraception during the study. This may also apply to subjects with documented hypogonadism with and without estrogen replacement therapy as per investigator judgement. All other females of child-bearing potential must agree to use contraception as outlined in the protocol Males with female partners of childbearing potential must agree to a double barrier method if they become sexually active during the study and for 90 days following the study. Patients must be on a stable dose of any allowed chronic concomitant medications while participating in the study, as described in protocol. This is defined as no changes in medication or dose for at least 30 days prior to Day 1 Stable concomitant usage (>3 months) of medications commonly used in PWS patients are allowed  Exclusion Criteria:  Use of weight loss agents, including herbal medication, within 3 months prior to enrollment Diagnosis of schizophrenia, bipolar disorder, personality disorder, or other DSM-III disorders which the investigator believes will interfere significantly with study compliance A PHQ-9 score of ≥10 Any suicidal ideation of type 4 or 5 on the C-SSRS Clinically significant illness in the 8 weeks prior to enrollment History of clinically significant bleeding disorders Current, clinically significant liver, renal, pulmonary, cardiac, oncologic, or gastrointestinal (GI) disease Diagnosis of type 1 diabetes mellitus or other active endocrine disorders (e.g., Cushing syndrome, or thyroid dysfunction except if on stable adequate thyroid or glucocorticoid replacement supplement) Liver disease or liver injury as indicated by abnormal liver function tests, SGOT (aspartate aminotransferase (AST)), alkaline phosphatase, or serum bilirubin (> 1.5 x upper limit of normal (ULN) for any of these tests) or history of hepatic cirrhosis History or presence of impaired renal function as indicated by clinically significantly abnormal creatinine, blood urea nitrogen (BUN), or urinary constituents (e.g., albuminuria) or moderate to severe renal dysfunction as defined by the Cockroft Gault equation (< 50 mL/min) Significant history of abuse of drugs within 1 year prior to enrollment or a positive Drugs of Abuse (DOA) test at screening History of alcohol abuse within 1 year prior to enrollment or currently drinks in excess of 21 units per week (3 servings or units/day) Caffeine consumption exceeding 6 cups of caffeinated tea/coffee (or equivalent) per day Participation in any clinical study with an investigational drug/device within 1 month prior to enrollment Serious adverse reaction or significant hypersensitivity to any drug Clinically significant blood loss or blood donation > 500 mL within 3 months prior to enrollment Inadequate venous access History of significant drug hypersensitivity or anaphylaxis Any condition that the investigator or primary physician believes may not be appropriate for participating the study