Inclusion Criteria:  Aged ≥20 years at time of informed consent Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) of 0 or 1 HCC that has been histologically confirmed  Exclusion Criteria:  Previous or concomitant autoimmune disease Uncontrolled diabetes mellitus and hypertension Concurrent New York Heart Association (NYHA) Class ≥II congestive heart failure, myocardial infarction, arrhythmia, or unstable angina, or a history thereof within 6 months before enrollment. Concurrent symptomatic cerebrovascular disorder (e.g., subarachnoid hemorrhage, cerebral infarction, or transient ischemic attack), or a history thereof within 6 months before enrollment. Symptomatic, untreated, or actively progressing CNS metastases