Inclusion Criteria:  Male or female ≥18 years of age Patients with gastrointestinal tumors or breast cancer who will be treated with capecitabine Indication of adjuvant or palliative treatment with capecitabine Eastern Cooperative Oncology Group (ECOG) 0-2 Information of the patient and signature of the informed consent form by the patient or her legal representative.  Exclusion Criteria:  Previous chemotherapy with capecitabine Pre-existing patients with neuropathies Patients with known allergic reactions to any of the ingredients of the investigational product Patients with dermatological conditions that affect the hands or feet Patients with rectal neoplasia and indication for neoadjuvant treatment.