Inclusion Criteria:  Pregnant women with singleton pregnancies ≥18 years old Estimated gestational age less than 24 weeks Meet criteria for an exam indicated cerclage Patients must also be able to provide consent, demonstrate an understanding of the purpose of the study, and agree to the study protocol.  Exclusion Criteria:  Human immunodeficiency virus (HIV) positive status Known prolonged QT syndrome Major fetal congenital anomalies Temperature of 100.4 F or higher Prior cerclage during the current pregnancy Contraindication to indomethacin Allergy to both penicillin and clindamycin Received indomethacin or any antibiotics within 7 days before their presentation