Inclusion Criteria:  Must be at least 20 years old and less than 80 years old With anesthesia risk grade below grade three (including grade three) (ASA I~III) Patients who are expected to undergo intracranial surgery for skull pin fixation  Exclusion Criteria:  Those with anesthesia risk classification ASA class IV or higher Those who are allergic to opioid analgesics or propofol drugs Emergency patients