Inclusion Criteria:  Understood and Signed an informed consent form., with good compliance Age: 18-75 years old；.Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2；Life expectancy of at least 3 months. Glioblastoma confirmed by histology ; Random time is 4-6 weeks from the last operation , and the investigator judges that the surgical wound has healed well; Within 5 days before administration, the dosage of corticosteroids was stable or gradually decreased; Male or female subjects should agree to use an adequate method of contraception starting with the first dose of study therapy through 6 months after the last dose of study ；Not Pregnant or breastfeeding women,Pregnancy before pregnancy screening, the women who blood / urine results were positivetherapy.  Exclusion Criteria:  Have previously received systemic radiotherapy and chemotherapy for GBM; IDH1/2 mutations are present Contraindicated for MRI examination The tumor only occurs in the brain stem Radiologically obvious diffuse meningeal dissemination Imaging shows that the tumor has invaded the periphery of important blood vessels or the investigator judges that the tumor is very likely to invade important blood vessels and cause fatal hemorrhage, cerebrovascular malformations or other bleeding tendency during the subsequent study period; Patients with arterial or venous thromboembolic events occurred within 6 months, such as cerebrovascular accident , deep vein thrombosis and pulmonary embolism； Other malignant tumors have occurred or are currently present at the same time within 3 years. There are many factors that affect oral medications ; Received anti-tumor Chinese patent medicine which were approved by NMPA Within 2 weeks before the start of the study. A clear history of neurological or psychiatric diseases, moderate or higher epilepsy , moderate or higher aphasia or dementia Participated in other anti-tumor drug clinical trials within 4 weeks before grouping; Other conditions which are not fit for this study assessed by investigator.