Inclusion Criteria:  histologically confirmed squamous cancer of nasal cavity and paranasal sinuses T4bN0-3M0 (AJCC8th) or unresectable lymph nodes or refusal of surgery KPS≥70 NE≥ 1.5×10E9/L, HGB ≥ 100g/L and PLT ≥100×10E9/L ALT≤ 1.5 upper limit of normal (ULN), AST≤ 1.5ULN and bilirubin ≤ 1.5ULN creatinine clearance rate ≥ 60 ml/min (calculated by Cockcroft-Gault)  Exclusion Criteria:  older than 65 or younger than 18 HBsAg (+) and HBV DNA >1×10E3 copiers /mL HCV (+) HIV (+) autoimmune diseases interstitial lung diseases had other cancers before