Inclusion Criteria:  Age ≥ 18 years at the time of screening or age of consent. Written informed consent obtained from the subject prior to performing any protocol-related procedures, including screening evaluations. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. Weight ≥ 35 kg. Must have a life expectancy of at least 12 weeks. Recurrent or newly diagnosed metastatic non-small cell lung cancer Tumor PDL1 status <50%. Non-Squamous and squamous histologies are eligible Histologies with targetable mutations are not eligible, regardless of prior treatment with tyrosine kinase inhibitors No prior radiation, surgery or chemotherapy is allowed for the current diagnosis of non-small cell lung cancer Adequate organ and marrow function  Exclusion Criteria:  Receipt of any conventional or investigational anticancer therapy within 21 days or palliative radiotherapy within 14 days prior to the scheduled first dose of study treatment. Prior receipt of any immune-mediated therapy. Incomplete surgical resection Concurrent enrolment in another therapeutic clinical study. Enrolment in observational studies will be allowed. Any toxicity (excluding alopecia) from prior standard therapy that has not been completely resolved to baseline at the time of consent. Participants with prior history of myocardial infarction, transient ischemic attack, congestive heart failure ≥ Class 3 based on New York Heart Association Functional Classification or stroke within the past 3 months prior to the scheduled first dose of study treatment. Active or prior documented autoimmune disorders within the past 3 years prior to the scheduled first dose of study treatment with exceptions. Participants with confirmed human immunodeficiency virus (even if viral load is undetectable), chronic or active hepatitis B or C, or active hepatitis A. History of primary immunodeficiency, solid organ transplantation, or active tuberculosis (by clinical evaluation that includes clinical history, physical examination and radiographic findings, and tuberculosis testing in line with local practice). Other invasive malignancy within 2 years. Non-invasive malignancies (i.e., cervical carcinoma in situ, in situ prostate cancer, non-melanomatous carcinoma of the skin, ductal carcinoma in situ of the breast that has been surgically cured) are excluded from this definition. Known allergy or hypersensitivity to investigational product formulations. History of more than one event of infusion related reactions requiring permanent discontinuation of intravenous drug treatment. Uncontrolled intercurrent illness including, but not limited to ongoing or active infection requiring antibiotic therapy, uncontrolled hypertension, bleeding diatheses, or psychiatric illness/social situations that would limit compliance with study requirements, substantially increase risk of incurring adverse events, or compromise the ability of the subject to give written informed consent. Current or prior use of immunosuppressive medication within 14 days prior to the scheduled first dose of study treatment with exceptions. Receipt of live, attenuated vaccine within 30 days prior to the scheduled first dose of study treatment - Major surgery within 28 days prior to scheduled first dose of study treatment or still recovering from prior surgery. Females who are pregnant, lactating, or intend to become pregnant during their participation in the study. Participants who are involuntarily incarcerated or are unable to willingly provide consent or are unable to comply with the protocol procedures. Any condition that, in the opinion of the investigator, would interfere with safe administration or evaluation of the investigational products or interpretation of subject safety or study results.