Inclusion Criteria:  Men or Women. Aged 30-65 years. Ambulatory systolic blood pressure ≥ 135 mmHg and/or diastolic blood pressure ≥ 85 mmHg. Ambulatory daytime systolic blood pressure standard deviation (SD)≥13mmHg. Never took antihypertensive drugs. Signed the written consent.  Exclusion Criteria:  Under antihypertensive treatments. Clinic systolic blood pressure ≥ 160mmHg and/or diastolic blood pressure ≥ 100mmHg. Contraindications to the treatment of drugs, including hypersensitivity reaction, bradycardia, asthma, etc. Any cardiovascular disease except hypertension. Suspected or confirmed secondary hypertension. Poor compliance.