Inclusion Criteria:  Able and willing to sign the Patient Consent Form and adhere to study visitation schedule Antral follicle count (AFC) ≥ 5 and ≤ 10 Anti-Mullerian hormone (AMH) ≤1.5 ng/ml (AMH result of up to one year will be valid) Age ≥ 35 years and ≤40 years BMI ≥18.5 and <25 kg/m2  Exclusion Criteria:  AFC >10 History of untreated autoimmune, endocrine or metabolic disorders Contraindication for hormonal treatment Preimplantation genetic diagnosis cycles Severe male factor (sperm concentration <5 M/mL) Recent history of severe disease requiring regular treatment (clinically significant concurrent medical condition that could compromise subject safety or interfered with the trial assessment and patients with any contraindication of being pregnant).