Inclusion Criteria:  A form of chronic pain disorder other than chronic lower back pain (cLBP) - examples include chronic pain associated with rheumatoid arthritis, fibromyalgia, neuropathy, neuralgia, etc. Forms of cLBP not allowed in Back Pain Consortium Research Program Study Mechanistic Research Center(sacroiliitis or a spondyloarthropathy, e.g. ankylosing spondylitis). Definition of chronic pain suggested by the 2014 NIH Pain Consortium, i.e. pain present at least six months, and present more than half of those days Individuals must have a pain interference score of ≥60 on Patient-Reported Outcomes Measurement Information System (PROMIS) Pain Interference. The normal population mean for pain interference is 50.  Exclusion Criteria:  Unable to speak and write English Visual or hearing difficulties that would preclude participation Chronic pain from migraine headaches. Chronic pain from cancer. Severe psychiatric disorders that in the opinion of the investigative team would interfere with participation in the study. This includes any active suicidal ideations or history of suicide attempts, because of safety issues concerning administering duloxetine to such individuals Current severe substance use disorder (mild or moderate substance use that is being managed / treated will be accepted)