Inclusion Criteria:  STEMI patients with heavy thrombus burden as assessed by TIMI score of 0-1 or thrombus burden classification 4-5  Exclusion Criteria:  STEMI patients with low thrombus burden (TIMI 2-3 or TB 0-3) History of hypersensitivity or allergy to any of the study drugs, as well as known or suspected contraindications to the study drugs. Symptomatic hypotension and/or an SBP < 100 mmHg at the time of randomization.