Inclusion Criteria:  Male or female patients aged from 12 years or older with a diagnosis of CS Patients who started ketoconazole therapy after study start For patients previously treated with ketoconazole, patients must have taken their last dose at least 6 months before starting ketoconazole again in this study. Written informed consent signed prior to registration of any patient data in HRA modules.  Exclusion Criteria:  Adrenal cortical carcinoma Patients currently participating in any other trial (interventional or not) of an investigational medicine or participation in the past one month before start of ketoconazole Patients who have at least one contraindication among those listed in section 4.3 of the ketoconazole SmPC