Inclusion Criteria:  Age >18 years, admitted to the ICU Septic shock according to the Sepsis-3 criteria and a norepinephrine requirement ≥0.2µg/kg/min despite adequate fluid resuscitation Acute kidney injury at or after ICU admission and the treating physician considers that initiation of CRRT is likely within 48 hours. Informed consent from the patient or family members is received  Exclusion Criteria:  Maintenance dialysis dependency or RRT during current hospital stay prior to ICU admission GFR less than 20ml/kg/1.73m2 prior to hospital admission (within 365 days) Neurosurgical patients Pregnant women Patient's lack of commitment to start RRT Chronic or acute clinical condition with a prognosis below 6 months History of heparin allergy or heparin induced thrombocytopenia