Inclusion Criteria:  18 Years and older signed the informed consent indicated for revascularization, with possible bypass segment in LAD and amendable lesions by PCI in other vessels anatomy requiring as following: (1) Multivessel CAD involving the LAD (proximal or mid) and/or LM (ostial, mid-shaft or distal) with at least 1 other epicardial coronary artery requiring treatment in LCX or RCA, including: (2) LAD disease, and a major diagonal lesion, either bifurcation or independent in location, with both requiring revascularization (determined by QFR or FFR) (3) LM distal bifurcation lesion (Medina 1,1,1), intended for 2-stent approach if randomized to PCI Heart team discussion after angiogram, with conclusion of suitable candidate for either PCI or HCR Able to tolerate and no plans to interrupt dual anti-platelet therapy for 3~12 months Willing to comply with 2-year clinical follow-up  Exclusion Criteria:  Previous cardiac or thoracic surgery Previous PCI of the LM and/or LAD within 12 months Totally occluded left main vessel Cardiogenic shock or LVEF <30% Previous STEMI within 30-day prior to randomization Concomitant vascular or other cardiac disease with plan of surgical treatment Indication for chronic oral anticoagulation therapy Previous stroke history within 6-month prior to randomization Survival expectation less than 3 years due to non-cardiac illness Allergy or hypersensitivity to any of the study drugs or devices used in the trial Enrolled in additional clinical study Informed consent not available or noncompliance with follow-up Pregnant