Inclusion Criteria:  Patients with one or multiple pathologically proven malignancies in the head and neck region (targeted lesions), independent of origin and stage. Patient is planned for the surgical resection of the targeted lesion. Age ≥ 18 years. Karnofsky performance scale ≥30 Patient has given informed consent according to the International Conference on Harmonization (ICH) Good Clinical Practice (GCP) guidelines in accordance with the declaration of Helsinki.  Exclusion Criteria:  Patient is planned for a treatment regimen which does not include standard surgical resection of the targeted lesion. Pregnant or actively lactating women. Blood glucose level ≥ 200mg/dl or more on the day of surgery.