Inclusion Criteria:  Male or female subjects over 18 years Histologically and endoscopically proven Barrett's esophagus requiring ablation therapy according to the current guidelines General health status sufficient to perform an endoscopic procedure (ASA I-III)  Exclusion Criteria:  Primary or secondary coagulopathy, with INR>1.5 and/or platelet count of <75,000. Anticoagulation therapy (e.g. warfarin) for high-risk condition and unable to withhold the medication temporarily Recent myocardial infraction or other significant cardiovascular event within 6 months prior to recruitment Patients under long-term care and/or within nursing facilities (e.g. psychosocial disorders, mental retardation) Any history of esophageal resection surgery Esophageal varices