Inclusion Criteria:  femur fractures type 31-A1, A2, (Muller ME, Nazarian S, Kock P et al.); age 60 - 85 years; co-operative patients; Body Mass Index (BMI) < 30 Kg/m²; patients treated by intramedullary nailing surgery (PFNA Synthes®); patients with osteoporosis disease if T-Score< -2,5;  Exclusion Criteria:  patients with heart, kidney, neurological diseases; patients with metabolic and systemic disease (rheumatoid arthritis, diabetes mellitus); previous surgery or severe osteoarthritis of lower limbs; specific drugs treatments such as anticoagulants or psychiatric drugs.