Inclusion Criteria:  The age of patients ranges from 15-20 years old. Mild to moderate dental irregularity requiring non-extraction treatment. Presence of all the permanent teeth at least up to the first molars. Good oral hygiene, and periodontal health.  Exclusion Criteria:  Patients require orthognathic surgery to correct skeletal discrepancies. patients who are taking medications, like NSAIDs or other anti-inflammatory drugs. cleft lip or palate patients. patients with hypodontia, or hyperdontia.