Inclusion Criteria:  Patients requiring tumor ablation; Voluntarily participate and sign the informed consent.  Exclusion Criteria:  Allergic to contrast agent, test drug or other ingredients; With a history of substance abuse, chronic pain and mental illness; Use of any monamine oxidase inhibitor within 14 days prior to randomization; Pregnant or breastfeeding; Cannot tolerate ablation due to other reasons; Cannot express their wishes correctly; Poor compliance, unable to complete the trial; Have participated in other drug trials within 30 days prior to enrollment; Judged by the researcher to be unsuitable.