Inclusion Criteria:  Non pregnant women confirmed to have endometriosis by histopathology and not received any hormonal treatment yet. Also, medical treatment was the proper choice for treatment of each case.  Exclusion Criteria:  Women suspect pregnancy. Breast feeding women. Previous use of hormonal agents (progestin less than 6 months, danazol less than 3 month, oral contraceptive pills less than 1 month before screening). Women with other gynecological pathology interfere with treatment we will use. Using of corticosteroids. Family history of osteoporosis.