Inclusion Criteria:  Subject has Parkinson's disease of ≤2 years of duration, defined as the time since the diagnosis was made by a neurologist. Subject is an adult, at least 18 years of age. Subject can read and understand Dutch. Subject has completed the IRB-approved Informed Consent. Subject is willing, competent, and able to comply with all aspects of the protocol, including follow-up schedule and bio-specimen collection. Subject has never been treated before with any symptomatic dopaminergic drug treatment for Parkinson's disease and is not expected to start treatment for motor symptoms of PD within 52 weeks from baseline.  Exclusion Criteria:  Subject has co-morbidities that would hamper interpretation of parkinsonian disability, such as coincident musculoskeletal abnormalities, in the opinion of the Investigator. Subject is taking Mucuna Pruriens. For Study Watch: subject is allergic to nickel.