Inclusion Criteria:  Participants scheduled to undergo a screening, surveillance or symptomatic colonoscopy with an endoscopist participating in the study phase of the trial. Male and female participants aged 18 years or older at the time of informed consent. Participants able to comprehend, sign and date the written informed consent document to participate in the study.  Exclusion Criteria:  Emergency and/or inpatient colonoscopies Participants with inflammatory bowel disease (IBD) Participants with current Colorectal Cancer (CRC)  Participants with a contraindication for biopsy or polypectomy. These include:  Participants who have not withheld medications pre-disposing to bleeding at time of colonoscopy as per local site /national guidelines. Participants with a history of haemostasis disorders (haemostasis disorders will include but will not be limited to: participants with haemophilia or other congenitally acquired clotting factor deficiencies, participants with cirrhosis with coagulopathy, participants known to have thrombocytopenia (<80,000 platelet/ul) and individuals with Von Willebrand's disease or other known platelet malfunction disorders) Participant is enrolled in another research study with an investigational medicinal product (IMP) or non-IMP that pre-disposes them to bleeding