Inclusion Criteria:  PIRADS 4 and 5 prostate lesions and PIRADS </= 3 prostate lesions with high clinical suspicion. Patients who are included in the study will be randomly allocated into either PSMA PET/CT guided biopsy or TRUS guided biopsy using simple randomization in RRApp  Exclusion Criteria:  Patients with acute prostatitis/ urine culture positive. Patients with pre-existing bleeding diathesis like hemophilia, coagulopathy defined by INR ≥ 1.2, and Platelet counts ≤ 80,000/mm3 Patients who refuse to provide the written informed consent Non-cooperative patients