Inclusion Criteria:  Patient with a neurodevelopmental disorder and presenting one of the following criteria:  Motor development delay Cerebral palsy Hypotonia / hypertonia Movement disorders: Oculogyric crises, dystonia, hypokinesia / bradykinesia Catatonia Dysautonomia: ptosis, excessive sweating, intermittent hypothermia, nasal congestion, fluctuating blood pressure Epileptic encephalopathy Autism spectrum disorder Absence of cerebral structural abnormality on MRI apart from corpus callosum abnormality, white matter non-specific abnormality or cerebral atrophy Collection of informed consent signed by both parents or legal guardians and by the child if possible or formed consent signed by adult Patient benefiting from a social security scheme  exclusion criteria  Patient who had already have a neurotransmitter profiling or a measure of AADC enzymatic activity Patient with a clearly defined anoxo-ischemic history Patient with issues in blood collection