Inclusion Criteria:  Systemically healthy patients. Stage III Grade B periodontitis.  Exclusion Criteria:  Medical history of systemic disease: diabetes, pregnancy or lactation. Previous periodontal treatment for the last 6 months Grade II mobility Smoker or alcoholic patient. Teeth with untreated caries, endodontic lesions Symptoms of recent acute illness e.g., COVID-19 will be excluded as well