Inclusion Criteria:  Primary diagnosis histologically confirmed invasive breast carcinoma pT1-4 pN0 or pN+ cM0 curative-intended breast-conserving therapy (BET) ± (neo-) adj. system therapy with subsequent adjuvant radiotherapy of the breast ± lymphatic drainage system planned informed consent of the patient  Exclusion Criteria:  DCIS, Inflammatory breast carcinoma Recurrence situation Presence of distant metastases Second malignancies < 10 years prior to diagnosis of breast carcinoma Prior exposure to radiotherapy