Inclusion Criteria:  Diagnosis of Hypertrophic Cardiomyopathy consistent with current US and European guidelines Ability to perform an upright treadmill cardiopulmonary exercise test Agreement to abide by contraceptive requirements  Exclusion Criteria:  Clinically significant concurrent condition which could prevent the patient from performing any of the protocol-specified assessments, represent a safety concern if the patient participates in the trial or could confound trial assessments of safety or tolerability Women who are pregnant, planning to become pregnant or lactating Participation in another clinical study involving a test product or invasive medical device within 28 days (or within 5 elimination half-lives of the respective test product, whichever is longer), prior to first dosing