Inclusion Criteria:  The age of the population is 18 or more than 18 years old. According to China PAR equations, Chinese guidelines and consensus on cardiovascular risk assessment and management，it is considered as healthy, low, medium, high and extremely high risk group. The subjects read and fully understood the patient's instructions and signed the informed consent  Exclusion Criteria:  Refused to sign informed consent. ACS is caused by surgery, trauma, or other diseases. Age less than 18 years old. Pregnant women. In the past 3 months, the patients were treated with trauma surgery. There are aortic dissection, pulmonary embolism, pneumonia, pericarditis, myocarditis, stress cardiomyopathy. Severe heart failure. Liver and kidney failure. Blood borne infectious diseases: including HIV / AIDS, hepatitis B, hepatitis C, etc. Patients with a history of malignancies, autoimmune diseases, severe infectious diseases and trauma. Any condition (such as travel, speech disorder, mental disorder) that the researcher believes can significantly limit the completion of the patient's follow-up.