Inclusion Criteria:  Patient with clinical stage IB to IIIA Non-small Cell Lung Cancer Patients with resectable lung cancer One of followings: 1) Never-smokers or ex-smokers who quit 10 years ago, 2) Female 3) Subsolid nodule in chest CT 4) Biopsy-proven adenocarcinoma  Exclusion Criteria:  Patients with metastatic lung cancer (Stage IIIB-IV) Patients who underwent chemotherapy or radiotherapy Patients with other malignancies