Inclusion Criteria:  Age 20 to 80 years; Coronary artery disease documented by coronary angiography; Use of aspirin 100mg.  Exclusion Criteria:  Serum creatinine dosage > 2.5 mg/dl; Hemoglobin <12 g/% for men and <11 g/% for women; Platelets <100,000 or >400,000/mm3; Leukocytosis >12,000/mm3; Fasting glycemia >126mg/dl; Aspartate aminotransferase (AST) and/or Alanine aminotransferase (ALT) with values above the upper limits of normality; Consumption of more than 30 grams of alcohol per day; Active smoking or ex-smoking for less than 2 years; Use of P2Y12 inhibitor; Ventricular dysfunction (left ventricular ejection fraction <45%).