Inclusion Criteria:  Adult patients Patients diagnosed with scleroderma (diffuse or limited) Patients with at least one digital ulcer, whether or not it is due to scleroderma Patients with 2013 ACR / EULAR Classification Criteria with a total score of ≥ 9 Patients already taking Bosentan (Klimurtan®) Patients who will sign the consent form for their participation in the study  Exclusion Criteria:  Patients with digital ulcers of other etiology, other than scleroderma Patients with severe pulmonary arterial hypertension (severe PAH- Category 3-4 according to WHO) Patients who do not meet the criteria for taking the study drug, according to the Summary of Product Characteristics