Inclusion Criteria:  Age 6-80 years old, gender is not limited patients who have been diagnosed with systemic diseases; patients who have ever or never used any ocular toxic drugs such as corticosteroids, chloroquine, etc.; no history of glaucoma, cataract, scleritis, uveitis, ocular trauma, etc. before enrollment; willing to complete follow-ups for at least 2 years.  Exclusion Criteria:  Mainly use local therapies (intraocular, intra-articular and other non-systemic drug routes); history of intraocular surgery (such as lens implantation, vitrectomy, retinal photocoagulation); history of glaucoma, cataract, center serous retinopathy, etc.; history of various diseases (such as scleritis, uveitis, eye trauma, etc.) that may cause opacity of the eye under the posterior capsule; any other diseases or conditions that affect the observation, such as diabetes, low calcium convulsions, long-term exposure to radiation before enrollment; subjects with endogenous corticosteroids, or psychiatric diseases.