Inclusion Criteria:  Consecutive patients per 10-year age range, (20 patients per age range from 50 to 100 years included) :  hospitalization in one of the participating centres, treatment with clopidogrel 75 mg/d for at least 10 days for primary or secondary prevention of cardiovascular events. who have received the information and have not expressed their opposition to participate in the study and who have given their written consent for the performance of genetic examinations and the realization of a biocollection affiliated to French social security system  Exclusion criteria :  treatment with another antithrombotic agent, myeloproliferative syndrome, platelet count < 100 G/L, acute inflammatory situation: severe sepsis, documented acute infection, chronic systemic inflammatory disease or active cancer, under dialysis, no participation in another clinical study, deprived of liberty