Inclusion Criteria:  No known coagulopathy, no known esophageal varices. No significant dysphagia or odynophagia Absence of chronic GERD, defined as five or more years of heartburn or regurgitation with symptoms at least once a week when not on medications for GERD symptoms. Subjects to qualify must meet criterion 3, be over age 50, and have two additional risk factors for BE (white race, central obesity defined as waist size >35 inches for women and >40 inches for men, male gender, current smoker or smoking history >10 pack years, confirmed family history in at least two members with one being a first degree relative).  Exclusion Criteria:  History of prior EGD procedure Inability to provide written informed consent History of weekly of more frequent heartburn or regurgitation for five or more years On anti-coagulant drug(s)that cannot be temporarily discontinued or coagulopathy with international normalized ratio (INR) > 1.5 Known history of esophageal varices or esophageal stricture Any contraindication, as deemed inInvestigator's medical judgment, to undergoing the EsoCheck procedure, undergoing the EGDprocedure,and/or having biopsies taken, including but not limited to due to comorbidities such as coagulopathy or a known history of esophageal diverticula, esophageal fistula and/or esophageal ulceration History of difficulty swallowing (dysphagia) or painful swallowing (odynophagia), including swallowing pills Oropharyngeal tumor History of esophageal or gastric surgery, with exception on uncomplicated surgical fundoplication procedure History of myocardial infarction or cerebrovascular accident within past 6 months