Inclusion Criteria:  All newly admitted patients (shifted to ICU within 48 h of hospital admission)  Age ≥ 16 years Expected to stay in ICU or critical care areas for 7 days  Exclusion Criteria:  Patients with an admission diagnosis of a neuromuscular disorder  Patients with an admission diagnosis of stroke Patients with an admission diagnosis of cardiac arrest Patients with an admission diagnosis of traumatic brain injury Patients with an admission diagnosis of spinal injury Patients with an admission diagnosis of intracerebral infection or space-occupying lesion Patients transferred from ICU of another hospital Patients with a poor pre-hospital functional status (modified Rankin >3) Patients in whom no arms or no legs were available for muscle strength testing or ultrasound