Inclusion Criteria:  General  Potential subjects are required to meet all of the following criteria for enrollment into the study and subsequent randomization:  At least 18 years old. The index wound (i.e. current episode of the wound or ulcer) has been present for greater than 4 weeks prior to SV 1 and less than 1 year, as of the subject's consent for the study participation. The index wound is a minimum of 1.0 cm2 and a maximum of 25 cm2 at SV1. Subject understands and is willing to participate in the clinical study and can comply with weekly visits.  Subject must have read and signed the IRB approved Informed Consent Form (ICF) before study specific screening procedures that are not standard of care are undertaken.  DFU  Presence of diabetic foot ulcer (DFU) that meets all of the following features:  a. Wagner Grade 1 or 2 (see Appendix A for definitions), including wounds that extend to the ligament, tendon, joint capsule or fascia  Without abscess or osteomyelitis  The index ulcer will be the largest ulcer if two or more DFUs are present and will be the only one evaluated in the study. If other ulcerations are present on the same foot, they must be more than 2cm distant from index ulcer (edge to edge). The index ulcer has been offloaded for at least 14 days prior to randomization Adequate circulation to the affected foot as documented by a Clarifi SFDI Vascular Assessment Tool, or an Ankle Brachial Index (ABI) between 0.7 and 1.3 within 3 months of SV1, using the affected study extremity. As an alternative, arterial Doppler ultrasound can be performed, evaluating for bi-phasic dorsalis pedis and posterior tibial vessels at the level of the ankle within 3 months of SV1 or if monophasic wave forms present must have adequate micro circulation as evidenced by Clarifi SFDI Vascular Assessment Tool. Note: A documented record of an ABI test performed using the index ulcer leg, within 3 months of SV1 is acceptable for the purposes of this study. Otherwise, this must be completed in the Screening Visit. Acceptable alternatives include arterial Doppler ultrasound evaluating for biphasic dorsalis pedis and posterior tibial vessels at the level of the ankle, or documented adequate microcirculation as determined by a Clarifi SFDI Vascular Assessment Tool.  VLU  All wounds using the CEAP VLU Classification, except for those in the exclusion criteria. (See Appendix A for definitions)  The index ulcer will be the largest ulcer if two or more VLUs are present and will be the only one evaluated in the study. If other Ulcerations are present on the same leg, they must be more than 2cm distant from index ulcer.  Surgical Dehisced  All wounds using the Sandy Grading System, except those in the exclusion criteria. (See Appendix A for definitions) Traumatic All wounds as per the CDC Surgical Wound Classification, with the exception of Class IV or dirty infected wounds, SSI - Deep incisional and organ space. (See Appendix A for definitions)  Exclusion Criteria:  General  Potential subjects meeting any of the following criteria will be excluded from enrollment and subsequent randomization:  The index wound, in the opinion of the investigator, is suspicious for cancer or have a positive carcinoma diagnosis. Subject has a history of more than two weeks of treatment with immune-suppressants (including systemic corticosteroids >10mg daily dose), cytotoxic chemotherapy, or application of topical steroids to the wound surface within 1 month prior to first SV1, or who receive such medications during the screening period or who are anticipated to require such medications during the course of the study. Subject is taking a selective COX-2 inhibitor, such as Celecoxib, for any condition. Subject is on any investigational drug(s) or therapeutic device(s) within 30 days preceding SV1. History of radiation at the wound site (regardless of time since last radiation treatment). Index wound has been previously treated or will need to be treated with any prohibited therapies (See Section 6 of this protocol for a list of prohibited medications and therapies). Subject has a previous diagnosis of HIV, Hepatitis C, or other contagious diseases. Presence of any condition(s) which seriously compromises the subject's ability to complete this study or the subject has a known history of poor adherence with medical treatment. Subject is pregnant or breast-feeding. Presence of diabetes with poor metabolic control as documented with an HbA1c >12.0 % within 90 days of randomization. Subject has end-stage renal disease as evidenced by a serum creatinine > 3.0mg/dL within 6 months of randomization. BMI >40 DFU Wagner 2 wounds that require debridement of bone.  Osteomyelitis or bone infection of the affected foot as verified by x-ray, CAT Scan, or MRI within 30 days prior to randomization (In the event of an ambiguous diagnosis, the Principal Investigator will make the final decision).  VLU  Exclude  Secondary post thrombotic Venous Obstruction Venous Obstruction with reflux Lipodermato sclerosis or atrophic blanche  Osteomyelitis or bone infection of the affected leg as verified by x-ray, CAT Scan, or MRI within 30 days prior to randomization (In the event of an ambiguous diagnosis, the Principal Investigator will make the final decision).  Surgical Dehisced  Using the Sandy Grading System for Surgical Wound Dehiscence: Wounds Grade 3 where organs are exposed, and 3a, where the infection is severe as deemed by the Principal Investigator.  Traumatic  Using CDC Surgical Wound Classification, exclude  Class IV - dirty infected wounds SSI - Deep incisional and organ space