Inclusion Criteria:  Patients must meet DSM-5 criteria for major depressive disorder with and without anxiety symptoms Patients must also be symptomatic (i.e. symptom severity above clinical thresholds using standard rating scales) and, if relevant, stable treatment(s) for >6 weeks. Healthy volunteers must have an absence of psychiatric disorders ( >6 months; lifetime for major depression and PTSD) and absence of psychiatric medications of therapy for >6 months  Exclusion Criteria:  history of seizure disorder or serious neurologic illness including dementia structural or neurologic abnormalities present or in close proximity to sonication site for patients (e.g., clinically significant calcification as might be observed in Fahr disease) history of brain surgery, iv) pacemaker or implanted central nervous system device greater than mild traumatic brain injury, or any head injury within sixty days of participation greater than moderate alcohol or substance use disorders (last six months; excluding nicotine/caffeine) active use or withdrawal from alcohol or substances (assessed via breathalyzer/urine testing as indicated) metal in the head impediment to vision, hearing and/or hand use likely to interfere with assessments pregnant or lactating (assessed via pregnancy test) unable to follow protocols acute suicidality, defined as "Yes" on item 4 of the Columbia Suicide Severity Rating Scale (C-SSRS), (i.e., active suicidal ideation with some intent to act on thoughts), or any endorsement of item 5 (active ideation with specific plan and intent) or any actual, interrupted, aborted attempt or preparatory behavior within the past month. symptom threshold considered in the "very severe" range using standard rating scales will be excluded.