Inclusion Criteria:  Patients between the ages of 18-65, Patients who accept the study,  Patients newly admitted to the clinic, Patients whose vascular access will be opened in the clinic, Patients whose upper extremity can be used for vascular access, Patients not receiving chemotherapy, Patients using antibiotics and analgesics containing the same active substance in intravenous drug treatment, Patients not discharged before 72 hours, Patients without blood disease, Patients without peripheral vascular disease,  Exclusion Criteria:  Patients younger than 18 and older than 65, Patients who do not accept the study, Patients with peripheral vascular disease, Patients with blood disease, Patients receiving chemotherapy,  Patients who do not use the upper extremity,