Inclusion Criteria for centers:  A tertiary children's hospital with more than 300 beds The vice president in charge of nursing affairs, the director of nursing department and the director of hospital infection control department all agree in participating in this study with written permission, which include total acceptance of infusion management scheme and outcome indicators report as required To obtain the approval from Ethics Committee of the hospital  Inclusion Criteria for patients:  Hospitalized children aged 0~18 years Catheterization and maintenance in the same center The indwelling time is longer than 48h  Exclusion Criteria:  The vice president in charge of nursing affairs or the director of nursing department inform the researcher to withdraw from this study with written form and should clear reasons The number of cases for suspected CLABSI sample actually submitted for inspection / The number of cases for suspected CLABSI sample should submitted for inspection<0.9 The awareness rate of infusion management scheme in clinical nurses is less than 90% and the qualification rate of the practice examination in clinical nurses is less than90% during inspection