Inclusion Criteria:  Adults (age 18-65 years) of American society of anesthesiologists (ASA) I-II who will be diagnosed with sepsis by qSOFA ≥2 & needed ICU admission.  Exclusion Criteria:  Chronic renal failure Liver cirrhosis Bleeding disorders or current anticoagulant therapy Pregnancy or breastfeeding Impaired color vision Severe vascular ischemia, history of venous thrombosis & pulmonary embolism Long term treatment with acetylsalicylic acid or non-steroidal anti-inflammatory drugs not discontinued before ICU admission Allergy to tranexamic acid (TXA)