Inclusion Criteria:  Adult patients presenting with NSTE-ACS planned for PCI Written informed consent  Exclusion Criteria:  Known allergy or contraindication for aspirin or P2Y12-inhibitors Concurrent use of oral anticoagulants (e.g. because of atrial fibrillation) Overwriting indication for DAPT (e.g. recent PCI or ACS) Planned surgical intervention within 12 months of revascularization Pregnant or breastfeeding women at time of enrolment Participation in another trial with an investigational drug or device (i.e. stent)