Inclusion Criteria:  Participant is willing and able to give and sign a written informed consent for participation in the study. Female aged 18 years or above. Diagnosed with early breast cancer (stage I and II) or metastatic breast cancer. Healthy participants who visit the site for reason other than cancer diagnosis (including breast cancer).  Exclusion Criteria:  History of other malignancies other than breast cancer (for healthy participants includes also breast cancer). Undergone surgery or treatment for breast cancer before enrollment (only for early breast cancer). Presence of known severe coagulation or haematological disorder Known Pregnancy Absence of written signed informed consent for participation in the study