Inclusion Criteria:  Patient is between the ages of 18-85 years, inclusive. Patient has a history of ulcerative colitis (UC) or Crohn's disease diagnosed by standard clinical, radiographic, endoscopic, and histopathologic criteria.  On one of the following treatment regimens for at least three months at the time of immunization and continued same therapy at the time of recruitment. Should be on stable doses defined as: Group A should have taken a dose of medication within the past week; Group B infliximab within the previous 8 weeks, golilumab within the previous 4 weeks, adalilumab within the previous 2 weeks, or certolizumab within the previous 4 weeks; Those on combination therapy in group B will have taken azathioprine or methotrexate within the past week. Group C ustekinumab at least within the previous 4 weeks. Those on combination therapy in group C will have taken azathioprine or methotrexate within the past week; Group D vedolizumab at least within the previous 4 weeks. Those on combination therapy in group D will have taken azathioprine or methotrexate within the past week.  Group A non-biologic group: mesalamine monotherapy or thiopurine monotherapy  Group B: Anti-TNF Therapy Group: on maintenance therapy infliximab (at least 5mg/kg every 8 weeks), golimumab (at least monthly), adalimumab (at least every 2 weeks), or certolizumab (at least monthly). Combination Therapy Anti-TNF Combination Therapy Group: on anti-TNF therapy as described above along with either 15mg of methotrexate or azathioprine at least 1.0mg/kg or 6MP 0.5mg/kg at least 40% of the group.  Approximately (40-50% of the group) will be combination therapy. Group C: Ustekinumab on either ustekinumab monotherapy or combination therapy with methotrexate or azathioprine. Group D: Vedolizumab Therapy Group: Vedolizumab Therapy: on either vedolizumab monotherapy or combination therapy with methotrexate or azathioprine Patient received a two-dose mRNA COVID-19 vaccine per standard of care  Exclusion Criteria:  Previous COVID-19 infection Patient cannot or will not provide written informed consent. Unable to provide appropriate informed consent due to being illiterate or impairment in decision-making capacity.