Inclusion Criteria:  The Diagnostic criteria of OCD in the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-V), as well as the definition of refractory OCD, are as follows: failure to respond to oral treatment with at least two effective doses of antidepressants, including: Fluoxetine (≥20mg/ d), fluvoxamine (≥200mg/d), sertraline (≥150mg/d), and paroxetine (≥ 40mg/d) were all treated for at least 12 weeks. The Yale-Brown compulsive scale (Y-BOCS) score decreased by < 35%. The total score of Yale- Brown compulsion scale (Y-BOCS) ≥16 points. (3)age 12 ~ 45 years.  Exclusion Criteria:  Exclusion of severe organic brain disease; Severe physical illness; Other mental disorders such as tics, disruptive disorders, eating disorders and autism spectrum disorders; Pediatric streptococcal infection causedby autoimmune neuropsychiatric disease (PANDAS); Alcohol and drug dependence; Angle-closure glaucoma; Suicidal tendencies; Previous history of drug allergies related to research; Pregnant and lactating women.