Inclusion Criteria:  The participant must have a major limb amputation. The participant is ≥ 18 years old at the time of consent. The participant must be in generally good health to undergo a surgical treatment, as per the clinical investigator's opinion. The post-operative amputation follow-up is greater than one year at time of consent. The participant must be diagnosed with neuroma pain, stump pain, or phantom limb in their residual limb, at latest the time of screening visit. The participant must have an average pain score (of neuroma pain, sump pain or PLP) greater than three on the Numerical Rating Scale (NRS, 0-10) after the baseline period. If the participant is prescribed pharmacological treatments for pain, there must be no variations in dosage (steady consumption) for at least one month before the screening visit. If the participant is prescribed non-pharmacological treatments for pain, such as spinal cord stimulation, transcutaneous electrical nerve stimulation or mirror therapy, the treatment must have ended at least one month before the screening visit. The participant has sufficient understanding of Swedish or English to be able to participate in all study assessments, as per the principal investigator's opinion.  Exclusion Criteria:  Neurological or other conditions that affect nerve regeneration. Active infection in the residual limb. Smokers or less than six weeks of smoking cessation at inclusion. Mental inability, reluctance or language difficulties that result in difficulty understanding the meaning of study participation, as per the principal investigator's discretion. Ongoing participation in a clinical study that the clinical investigator deems detrimental to participation in this study.