Inclusion Criteria:  Patients who developed recurrence of HCC after surgical resection . Age ≥ 18 years. Eastern Cooperative Oncology Group performance status (ECOG) of 0-2 . Patient with radiologically or pathologically confirmed hepatocellular carcinoma. Patients who had been treated with surgical approach as per our (Ain Shams University) institute protocols and developed recurrence after surgery. They were either intolerant to the institute protocol of treatment or showed unresponsiveness of their disease after treatment. Child-Pugh class A or B .  LAB values:  Hemoglobin (≥ 8 g/dl), platelets (≥ 50,000/µl), leukocytes (≥ 2,500/µl), neutrophils (≥ 1,000/µl), lymphocytes (≥ 500/µl) Liver function: serum bilirubin (< 3 x ULN), Alanine aminotransferase (ALT) or Aspartate aminotransferase (AST) (< 5 x ULN) Renal function: serum creatinine (< 1.5 x ULN)  Patient has not received any antineoplastic chemotherapy, immunotherapy, or radiotherapy for the four weeks prior to the start of study treatment. Pregnancy test should be negative at the first dose of study treatment in fertile females. (Female patients who are not post-menopausal or surgically sterile should use a highly effective method of birth control from the date of signing the consent to the last follow up visit. Pregnancy test should be negative at the first dose of study treatment.) Written informed consent .  Exclusion Criteria:  Patients receiving continuous systemic steroid treatment within the last 4 weeks prior to start of study treatment (The use of inhaled and nasally applied steroids, as well as topical steroids outside the vaccination area are permitted) Patients receiving systemic immunotherapy or immunosuppressant medication other than steroids within the last 4 weeks prior to start of study treatment. Patients with a history or evidence of systemic autoimmune disease. Active second malignancy or a prior malignancy within the past 12 months. Acute active infections requiring oral or intravenous antibiotics, antiviral or antifungal therapy within 1 week before the start of study treatment [Hepatitis B Virus (HBV) and/or Hepatitis C Virus (HCV) infections are permitted; direct-acting antivirals may be administered when medically indicated]. Any other acute medical condition that may compromise patient's safety or the activity of the studied vaccine treatment. Any other concurrent severe or uncontrolled chronic disease such as uncontrolled non-malignant liver, renal or lung disease, or decompensated cardiac failure or coronary insufficiency. Administration of a live, attenuated vaccine within 4 weeks before randomization Known previous major hypersensitivity reactions. History of human immunodeficiency virus (HIV) Evidence of current alcohol or drug abuse Women who are pregnant or who are breast feeding Medical or mental impairments that may limit participation in the study as judged by the investigators disease specialist. History of organ allograft. History of splenectomy. Psychiatric illness or known social situation that would preclude study compliance. Encephalopathy.