Inclusion Criteria:  Adult pregnant woman with singleton  For cases: diagnosis of intrahepatic cholestasis of pregnancy For controls: no diagnosis of ICP  Exclusion Criteria:  Women under 18 years old Women under legal protection Gemellar pregnancies Delivery before 22 Weeks of gestation Medical termination of pregnancy Acute chorioamniotitis, in particular those due to the following pathogens: toxoplasmosis, rubella, CMV, herpes virus Premature rupture of membranes