Inclusion Criteria:  postmenopausal women aged 50-70 years old with a clinical diagnosis of vaginal atrophy who will not need systemic estrogen therapy for the treatment of vasomotor symptoms or prophylaxis of osteoporosis Any parity.  Exclusion Criteria:  Women with any history of carcinoma of the breast or endometrium, abnormal genital bleeding, acute thrombophlebitis, or thromboembolic disorders associated with previous estrogen use, or current urinary. In addition, women who underwent hormone replacement therapy, treated with systemic or vaginal estrogen within 6 months prior to the study, or had any contraindication for estrogen therapy will be excluded from the study.