Inclusion Criteria:  Participants must be at least 50 years of age, inclusive, at the time of signing the Informed Consent Form (ICF). Participants must be capable of giving signed and legally effective informed consent  Exclusion Criteria:  Undergoing or referred for diagnostic evaluation due to clinical suspicion for cancer (e.g., referred to a medical or surgical oncologist, or scheduled for biopsy on the basis of a suspicious imaging abnormality). Personal history of invasive or hematologic malignancy, diagnosed within the 3 years prior to expected enrollment date, or diagnosed greater than 3 years prior to expected enrollment date and never treated. Definitive treatment for invasive or hematologic malignancy within the 3 years prior to expected enrollment date. Adjuvant hormone therapy for cancer (e.g. for breast or prostate cancer) is not an exclusion criterion. Individuals who will not be able to comply with the protocol procedures. Individuals who are not currently registered patients at a participating center. Previous or current participation in another GRAIL-sponsored study. "Participation" is defined as having signed consent and provided a blood sample. Previous or current employees or contractors of GRAIL.