Inclusion Criteria:  Male or female who is not of childbearing potential Body mass index of 18.0 to 32.0 kg/m^2, inclusive  Exclusion Criteria:  QTcF >450 msec at screening Clinically relevant abnormalities in conduction parameters; or if PR interval > 200 msec, QRS duration > 110 msec, or bradycardia or tachycardia (HR <45 bpm or >100 bpm) History or presence of hypokalemia, hypomagnesemia, or hypocalcemia Risk factors for Torsades de Pointes (TdP) (eg, congenital deafness, heart failure, cardiomyopathy, concomitant medications known to cause QTc prolongation) within a washout of at least 30 days Family history of Long QT Syndrome or family history of TdP Sick sinus syndrome, atrioventricular block (any degree) Myocardial infarction, pulmonary congestion, cardiac arrhythmia, prolonged QT interval, or conduction abnormalities Repeated or frequent syncope or vasovagal episodes Resuscitated arrest possibly due to TdP; hypertension, angina, or severe peripheral arterial circulatory disorders Use of concomitant medications that prolong the QT/QTc interval