Inclusion Criteria:  Patients undergoing neoadjuvant chemotherapy Surgery: Breast conservative surgery; Oncoplastic surgery type II; Conservative mastactomy (nipple sparing - NSM or skin sparing - SSM)  Exclusion Criteria:  lack of initial staging or restaging; previous or synchronous history of systemic malignant neoplasms. history of homo-or contralateral breast cancer. initial evidence of metastatic pathology or development of metastases during noeadjuvant chemotherapy (Stage IV) indication to modified radical mastectomy (MRM) without delayed reconstruction