Inclusion Criteria:  ≥18 years old; It meets the diagnostic criteria of China Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke 2018, and bleeding is confirmed by head MRI or excluded by CT after admission; Admission within 72 hours of onset. -  Exclusion Criteria:  Non-vascular causes and transient ischemic attack; with severe hepatic and renal dysfunction; Central nervous system infection, recent history of severe trauma, and malignant tumors affecting survival time; Incomplete main clinical data. -