Inclusion Criteria:  Age 18 years or older Scheduled for cardiac surgery with cardiopulmonary bypass and cardioplegic arrest Patient scheduled for elective cardiac surgery  Exclusion Criteria:  Patient with Diabetes Mellitus on sulfonylurea medications Scheduled for left ventricular assist device (LVAD) or heart transplant Left ventricular ejection fraction < 30% Pre-operative placement or planned use of mechanical circulatory support during surgery Allergy to Thiazide and its derivatives History of gout Patient is pregnant or breastfeeding