Inclusion Criteria:  Eligible participants will be adult patients (> 18 years) with onychomycosis confirmed by dermoscopy, direct KOH microscopic examination and positive culture..  Exclusion Criteria:  Patients with one or more with the following criteria will be excluded.  Pregnant and lactating women. Patients received topical and/or systemic antifungal therapy during the previous 3 months. Patients with impaired liver or renal functions. Patients with anemia (hemoglobin level <10mg/dl), thrombocytopenia (platelet count < 100,000 /µL), coagulopathies or patients on anticoagulant therapy as aspirin and patients with iron deficiency.