Key Inclusion Criteria:  Successful wear of spherical soft contact lenses with at least 3 months wearing experience, with a minimum wearing time of 5 days per week and 10 hours per day. Willing to wear habitual spectacles for vision correction when study lenses are not worn, as needed. Willing to wear contact lenses for at least 16 hours on the day prior to Visit 2 and the day prior to Visit 3. Other protocol-defined inclusion criteria may apply.  Key Exclusion Criteria:  Participation in a clinical trial within the previous 30 days or currently enrolled in any clinical trial. Habitual PRECISION1, Biotrue, and DAILIES TOTAL1 contact lens wear. Monovision and multifocal lens wear. Other protocol-defined exclusion criteria may apply.