Inclusion Criteria:  18-90 years old diarrhea (3 or more unformed stools per 24h for two consecutive days; or >= 8 unformed stools per 48h) XML File Identifier: KqQEbBLRYEZjGgsIl5GcI+NXCyM= Page 10/22 positive PCR test for toxin A/B genes and/or positive toxin EIA for current and previous episodes (low PCR cycle threshold value when only PCR performed) a minimum of two prior CDI episodes previous episode is maximum of 3 months prior to the current episode the current episode responds well to Standard of Care treatment (vancomycin or fidaxomicin orally). Assessment of the severity of the disease will be performed according to the ESCMID recommendations. Both mild and severe CDI will be included  Exclusion Criteria:  Severe complicated CDI, i.e presence of: hypotension, septic shock, elevated serum lactate, ileus, toxic megacolon, bowel perforation, or any fulminant course of disease. ICU admission for underlying disease pregnancy or current desire for pregnancy breastfeeding (prolonged) use of antibiotics (other than for treatment of CDI) during the study period or directly after the intervention previous use of bezlotoxumab or fecal microbiota transplantation a history of underlying congestive heart failure (potential safety signal phase-III trail bezlotoxumab). Diagnosis of inflammatory bowel disease in medical history.