Inclusion Criteria:  age from 2 months to 5 years old. voluntary participation in clinical trials, and informed consent; Contrast- Enhanced Ultrasonography proved HAT  Exclusion Criteria:  History of sensitivity to study medications or any of their excipients Renal failure (eGFR <30 or requiring dialysis) A known bleeding diathesis, hemostatic or coagulation disorder, or prior major bleeding Prior stroke Active pathological bleeding History of intracranial haemorrhage Life expectancy <12 months based on investigator's judgement Patients considered to be at risk of bradycardic events (e.g., known sick sinus syndrome or second or third degree atrioventricular [AV)] block) unless already treated with a permanent pacemaker Anemia (hematocrit < 27%) Platelet count < 100,000/ml Concomitant use of strong CYP 3A inhibitors or inducers