Inclusion Criteria:  Healthy male or female subjects ≥18 years of age, with appropriate sex ratio The body mass index is in the range of 19.0-27.0 kg/m2 (including the critical value). The weight of male is not less than 50.0 kg, and that of female is not less than 45.0 kg The subjects have no family planning within 3 months and could select contraceptive method. Before the study, all subjects have been informed of the study's purpose, protocal, benefits, and risks, and signed the informed consent voluntarily  Exclusion Criteria:  Subjects with allergic constitution. Being allergy to the study medications, smoking, alcohol abuse. Participation in another clinical trial within 3 months. Blood donation, massive blood loss (#400mL) or enrolled in other clinical trials 3 months prior to screening; Hepatitis (including hepatitis B and C), positive screening results for AIDS or syphilis;