Inclusion Criteria:  18 years of age and older willing to give informed consent hemodynamically stable de novo acute coronary syndrome patients with a stenosis of 50% and more by visual estimation in at least two separate coronary arteries adequate coronary flow, Thrombolysis in Myocardial Infarction (TIMI) flow ≥ 2 sinus rhythm  Exclusion Criteria:  inability to give consent; younger than 18 years of age atrial fibrillation rhythm at the time of inclusion with significant valve disease in cardiogenic shock with reduced kidney function - eGFR < 30 (mL/min/1.73m2); with congenital heart defects with acute pulmonary artery embolism; with isolated left main ostial stenosis; on active oncologic treatment or toxic cardiomyopathy; revascularization by PCI is not possible due to other comorbidities or patient denial of treatment.