INCLUSION CRITERIA:  In order to be eligible to participate in this study, the participant must:  State their willingness to complete all study procedures for the duration of the study 18 years of age or older at the time of screening Have a documented clinical diagnosis (upon review of medical records) of SCD or presence of a SCD hemoglobinopathy genotype HbSS, HgSC, HbSB 0 or HBSB+  EXCLUSION CRITERIA:  The following criteria will exclude any individual from participating in the study:  Less than 18 years of age Unable to speak, read, write, and/or understand English Presence of a condition or illness that will hamper the individual from giving informed consent (e.g. cognitive impairment) SCD trait genotype Currently undergoing inpatient treatment in any hospital for SCD at the time of screening Pregnancy at the time of screening