Inclusion criteria:  For Part A and B:  In-patients of the participating hospital in the last 10 years. Participant at any age.  For Part B additionally:  In addition for identified participants with a high likelihood of having FD- identified by the algorithm and confirmed by medical expert review as belonging to the top 50 FD candidates:  Participant and/or legal representative signed written informed consent form for study participation (including prospective data collection and genetic testing). In the opinion of the investigator, the participant is capable of understanding and complying with protocol requirements.