Inclusion Criteria:  Subject must be ≥ 18 years of age Subject must have received previous diagnosis of NPM1mut AML with or without concomitant FLT3-TKD or FLT3-ITD At screening, subject must have confirmed NPM1 type A, B, or D mutant transcripts Subject must be eligible for alloSCT, according to transplant center policy Subject must have undergone at least two cycles of conventional anthracycline- and cytarabine-based chemotherapy, achieving first CR (CR1)  Subject must be in morphological CR1 with bone marrow detectable minimal residual disease (MRD) positivity, defined as qRT-PCR NPM1 transcript ≥ 0.01/100 ABL1 copies and confirmed in two consecutive determinations performed at 2 to 4 weeks' distance  Molecular progression is defined in patients with molecular persistence at low copy number as an increase of MRD copy number ≥ 1 log10 between 2 positive samples. Molecular relapse is defined in patients previously tested MRD negative as an increase in MRD copy number ≥ 1 log10 between 2 positive samples Subject must have a projected life expectancy of at least 12 weeks. Subject must have an Eastern Cooperative Oncology Group (ECOG) Performance status < 2  Subject must have adequate renal and hepatic function per local laboratory reference range as follows:  Aspartate transaminase (AST) and alanine transaminase (ALT) < 3.0X ULN Bilirubin ≤1.5 x ULN (unless bilirubin rise is due to Gilbert's syndrome or of non-hepatic origin) Subject must have adequate renal function as demonstrated by a creatinine clearance ≥ 30 mL/min; calculated by the Cockcroft Gault formula or measured by 24 hours' urine collection. Female subjects of childbearing potential must have negative results for pregnancy test at screening Female and male patients who are fertile must agree to use an effective form of contraception with their sexual partners from screening through 3 months after the end of treatment. Signed written informed consent according to ICH/EU/GCP and national local laws.  Exclusion Criteria:  Subject has acute promyelocytic leukemia (APL) Subject has known active CNS involvement with AML Subject has received previous treatment with venetoclax and/or hypomethylating agents Subject has undergone alloSCT for AML Subject has more than 5% of bone marrow blast cells at screening bone marrow aspirate Subject is known to be positive for HIV  Evidence of other clinically significant uncontrolled condition(s) including, but not limited to:  Uncontrolled and/or active systemic infection (viral, bacterial or fungal) Chronic hepatitis B virus (HBV) or hepatitis C (HCV) requiring treatment. Note: subjects with serologic evidence of prior vaccination to HBV (i.e. hepatitis B surface (HBs) antigen negative-, anti-HBs antibody positive and anti-hepatitis B core (HBc) antibody negative) or positive anti-HBc antibody from intravenous immunoglobulins (IVIG) may participate. Cardiac history of CHF requiring treatment or Ejection Fraction ≤ 50% or chronic stable angina; DLCO ≤ 65% or FEV1 ≤ 65%; Creatinine clearance < 30 ml/min  Subject has a cardiovascular disability status of New York Heart Association Class > 2  a. Class 2 is i. defined as cardiac disease in which patients are comfortable at rest but ordinary physical activity ii. results in fatigue, palpitations, dyspnea, or anginal pain  Patients who are pregnant or breast feeding and adults of reproductive potential not employing an effective method of birth control (women of childbearing potential must have a negative serum pregnancy test within 48 hrs prior to administration of induction therapy). Post-menopausal women must be amenorrhoic for at least 12 months to be considered of non-child bearing potential. Male and female patients must agree to employ an effective barrier method of birth control throughout the study and for up to 3 months following discontinuation of study drugs. Patients unwilling or unable to comply with the protocol.