Inclusion Criteria:  Subject must have the ability to understand and sign written informed consent. Subject must be an adult male or female adult who is ≥ 18 years of age at the time of screening. Subject must be diagnosed with plaque psoriasis by either a dermatologist or a rheumatologist, with the affected area of ≥ 2 centimeters in diameter (study-lesion). Subjects must be treated with an anti-IL-17, anti-IL-23, or an anti TNF-α biologic Subject must abstain from the use of any treatment to the identified study-lesion after screening until the baseline visit (this includes biologic treatments until after the dermal patch sample has been collected). Subjects must abstain from the use of steroid or any topical treatment to the identified study lesion from screening till the last study visit. Subjects must have a baseline PASI ≥10 and the identified study-lesion must have a PGA severity ≥3 on a 5-point scale of 0 to 4. Agree to abide by the study protocol and its restrictions and be able to complete all aspects of the study, including all visits and tests.  Exclusion Criteria:  Subject is unable or unwilling to give written informed consent and/or to comply with study procedures. Subject has had new usage of topical psoriasis treatments within 2 weeks prior to screening study visit (these concomitant immunomodulatory treatments such as corticosteroid/calcineurin inhibitors). Subjects currently treated with Hydroxychloroquine (Plaquenil). Subjects has had usage of anti TNF-α, IL-12/23, IL-17, IL-23, JAK inhibitor, or T-cell activation inhibitor, therapy within 2 weeks prior to baseline, unless otherwise approved by Sponsor. More than 2 prior treatments with a biologic therapy. Subjects with a BMI ≥40 and a diagnosis of Class III (Severe) Obesity (or solely a diagnosis of Class III (Severe) Obesity). Any change in biologic medication (including change in dosage) between screening and randomization. No phototherapy or other oral systemic therapy (acitretin, ciclosporin, methotrexate, apremilast, fumarate, oral JAK inhibitor, or T-cell activation inhibitor) at least 2 weeks before baseline and throughout study.