Inclusion Criteria:  Patients scheduled to undergo elective thoracotomy for lung cancer European Cooperative Oncology Group 0 or 1 American Society of Anesthesiologists (ASA) physical classification I-III Willingness and ability to sign an informed consent document  Exclusion Criteria:  patients with chronic postoperative pain after thoracic surgery patients undergoing thoracotomy with chest wall resection allergies to anesthetic or analgesic medications patients with coagulopathy or who continue to take anticoagulants preoperative liver or renal dysfunction patients with chronic pain, chronic opioid, analgesic or antidepressant or anticonvulsant use Do not understand our study Medical or psychological disease that can affect the treatment response