Inclusion Criteria:  Aged 18 years or older Written informed consent Both sexes Patients with NAFL and NASH according to EASL Guidelines 2016.  Exclusion Criteria:  Patients on anti-platelet or anti-coagulant medications Reported severe immunosuppression Uncontrolled diabetes mellitus type 2 (HbA1c >7.0 %) Patients receiving PPAR-gamma and PPAR-alpha agonists Uncompensated cirrhosis defined as the presence of at least one of the following features: current or past cirrhosis complications (e.g. ascites, variceal gastrointestinal bleeding, hepatic encephalopathy), the presence of hyperbilirubinaemia (>2 mg/dl), hypoalbuminaemia (<3.2 g/dl), prolonged INR (>1.7), low platelet count, gastroesophageal varices at endoscopy. preexisting medical condition with a life expectancy of less than 3 months