Inclusion Criteria:  Any patient undergoing primary TKA with a diagnosis of osteoarthritis  •≥ 18 years old  Willingness to undergo randomization  Exclusion Criteria:  Reported chronic corticosteroid or opiate use Suspected or confirmed periprosthetic joint infection Revision TKA Primary diagnosis other than osteoarthritis, including avascular necrosis, fracture, or post-traumatic arthritis American Society of Anesthesiologists (ASA) score ≥ 4 Reported history of liver disease, renal disease, or diabetes mellitus Current systemic fungal infection or other local infection Immunocompromised or immunosuppressed Current peptic ulcer disease History of hypothyroidism, psychosis, heart failure, myasthenia gravis, ocular herpes simplex virus, or systemic sclerosis Women with reported current pregnancy  Known hypersensitivity to methylprednisolone  •≤ 18 years old  Inability to take oral medications Unable to provide consent