Inclusion Criteria:  Patients with moderate to severe persistent allergic rhinitis who meet the diagnostic criteria for allergic rhinitis (2015 Tianjin standard); The results of allergen examination showed that the allergen was a single allergy of dust mite; After more than 2 years of antihistamine, nasal glucocorticoid and other drug treatments, the curative effect is poor, and the symptoms seriously affect the patient's life; Age 18-60 years old; The patient refused to receive allergen-specific immunotherapy; The patient is willing to receive stem cell therapy and sign an informed consent.  Exclusion Criteria:  The subject is accompanied by sinusitis, asthma and aspirin intolerance; The subjects suffer from severe primary heart, liver, lung, kidney and blood diseases; The subjects suffer from Malignant tumors; The subjects suffer from severe immune diseases; The subjects suffer from mental illness; Female subjects who are or are about to become pregnant, pregnant or breastfeeding; Patients who are participating in other clinical trials; In addition to the above conditions, there are other reasons why researchers believe that they are not suitable to participate in this clinical study.