Inclusion Criteria:  Individuals with heterozygous Familial Hypercholesterolemia.  Exclusion Criteria:  Myocardial infarction or stroke within the last 6 months unstable angina, symptoms of angina within the last 3 months NYHA class III or IV heart failure or LVEF < 30% poorly controlled hypertension: SBP > 180 mm Hg or DBP > 110 mm Hg, pregnancy, evidence of a previous acute coronary syndrome, current smokers, individuals with Type 2 Diabetes Mellitus, obesity (BMI > 30), hypertriglyceridemia (fasting TG > 250 mg/dl), renal insufficiency (Cr > 1.8), hepatic disease (aspartate aminotransferase(AST) or alanine aminotransferase (ALT) > 2x ULN), hypothyroidism, nephrotic syndrome, rheumatoid arthritis, systemic lupus erythematosus, AIDS or HIV history of malignancy of any organ in last 5 years.