Inclusion Criteria:  Male gender at birth, age ≥18 years HIV negative by a routinely used assay within 4 weeks prior to or on the day of randomization Willing and able to provide written informed consent  And any one of:  condomless anal sex with a male on >1 occasion within the 90 days prior to randomization bacterial rectal sexually transmitted infection (STI) within the 90 days prior to randomization use of PEPSE in the 12 months prior to randomization following possible exposure to HIV through unprotected anal intercourse (UAI) with a male  Exclusion Criteria:  An acute viral illness that could be due to HIV seroconversion Any contraindications to Truvada or maraviroc according to the current SmPC allergic to soy or peanuts concomitant use of antihypertensive agents history of postural hypotension known hepBsAg positive current participation in a HIV PrEP or PEPSE study Any other active clinically significant condition, or findings during screening medical history or examination, or abnormality on screening laboratory blood tests that would, in the opinion of the investigator, compromise the patient's safety or outcome in the trial.