Inclusion Criteria:  Patients 18 years of age or older. Extremity fracture. Prior definitive fracture management with external fixation, internal fixation, or joint fusion. Superficial, deep, or organ space SSI (as per CDC criteria) at the fracture site that requires operative management. Will have all planned SSI care surgeries performed by a participating surgeon or delegate. Provision of informed consent.  Exclusion Criteria:  Fractures of the hand cannot be imaged. Iodine allergy. Burns at the SSI site. Incarceration. Expected survival of less than 90 days. Problems, in the judgment of study personnel, with maintaining follow-up with the patient. Adults unable to consent or whom do not have a LAR Individuals who are not yet adults (infants, children, teenagers) Pregnant or breastfeeding women