Inclusion Criteria:  being diagnosed with T2 diabetes with <10% HbA1C for at least 6 months, 30-65 years old patients, high caries activity patients with Periodontal Disease Index (PDI) scores of 2, 3, 4 and 5, provision of written informed consent -  Exclusion Criteria:  patients regularly using probiotics, patients on corticosteroid, non-steroid anti-inflammatory, antibiotic or antibacterial mouthwash therapy, patients with multi-organ deficiency such as liver or kidney failure, patients with Immunodeficiency syndrome or on immunosuppressive therapy, patients with heart valve prosthesis or central venous catheter, patients undergoing chronic or acute disease therapy such as cancer, arthritis, influenza, flu, legal incapability or mental incapacity to give consent.