Inclusion Criteria:  Clinical diagnosis of coronary atherosclerosis without indications for stent implantation. Age ≥ 18 years, ≤ 65 years Sign informed consent  Exclusion Criteria:  A history of asthma or allergic constitution or known allergy to indobufen or aspirin. High risk of bleeding (low hemoglobin 10g / L, history of peptic ulcer disease, fecal occult blood positive or known active bleeding, history of cerebral hemorrhage within 6 months, history of fundus hemorrhage, etc). Creatinine was 1.2 times higher than the upper limit of normal value and ALT was 1.2 times higher than the normal value. History of smoking and alcoholism. History of diabetes. Pregnancy and lactation women. Nonsteroidal anti-inflammatory or other antithrombotic drugs other than indobufen are required. Any other reason may affect the results of this study.