Inclusion Criteria:  Be older than 18 years old; Clinical or pathological diagnosis of Digestive tract diseases; Patients before receiving surgery, chemotherapy, radiotherapy, targeted therapy, local therapy, immunotherapy and other treatment measures； The patient had no tongue disease Patients understand and are willing to sign written informed consent.  Exclusion Criteria:  Patients unable to complete the process as required (mental disorder or poor compliance, etc.); The patient or guardian is unwilling to participate in this study; Combined with other serious systemic diseases (heart failure, renal failure,hematopoietic system disease or Uncontrollable acute infection);