Inclusion Criteria:  1.Adults patients ≥20 years who underwent lower extremity amputation for diabetic foot under general anesthesia or PNB and having coagulopathy in which condition that neuraxial block is contraindicated  Exclusion Criteria:  patients with prior surgical history within 1 month combined operation (joint operation) patients who required continuous intravenous administration of vasopressors and/or mechanical ventilation prior to surgery combination of general anesthesia and PNB