Inclusion Criteria:  A pruritus frequency of more than 3 days in previous week recorded by Q1 in The Patient Oriented Eczema Measure (POEM) History of known moderate-to-severe eczema Able to read Chinese voluntarily willing to participate into the study by written consents endorsed by patients and their legal guardians  Exclusion Criteria:  No history of known eczema Concurrently participating into another clinical trial History of known drug allergy unable to read Chinese