Inclusion Criteria:  Patient is 18 years of age or older Patient has a clinical indication for and has consented for primary or revision bilateral ESS and had evidence of ethmoid disease bilaterally (Lund-Mackay score at least 1 on each side). Diagnosed with CRS based on American Academy of Otolaryngology - Head and Neck Surgery guidelines  Exclusion Criteria:  Patient has a known history of immune deficiency such as immunoglobulin G or A subclass deficiency, or Human Immunodeficiency Virus (HIV). Patient has concurrent condition requiring active chemotherapy and/or immunotherapy management for the disease (e.g. cancer, HIV, etc.) Patient has clinical evidence of disease or condition expected to compromise survival or ability to complete follow-up assessments during the 90 day followup period. Patient is currently participating in another clinical trial. Patient has a known coagulation disorder. Patient is allergic to shellfish.