Inclusion Criteria:  All Subjects:  Ability to understand and provide written informed consent Age ≥ 50 years Current or Former Smoker  ≥ 20 pack-years (pack years = number of packs per day X number of years smoked)  AND  Inclusion Group 1: High Risk Patients that meet criteria 5 and 6 below:  Prior thoracic imaging (computed tomography (CT)) within 12 months of enrollment OR Planned thoracic imaging (CT) as part of standard of care within 6 weeks of enrollment  AND  Meet one of the criteria below:  No suspected or confirmed lung cancer diagnosis OR Suspected of lung cancer OR Confirmed, untreated lung cancer  Inclusion Group 2: High Risk Patients with cancer other than lung cancer that meet the following criteria:  Pathologic confirmed, solid-tumor cancer diagnosis, that is not lung cancer or non-melanoma skin cancer, with no prior systemic therapy, definitive therapy, radiation, or surgical resection.  Exclusion Criteria:  All Subjects:  History of previous cancer or therapy for cancer within the year prior to enrollment Any history of hematologic malignancies or myelodysplasia Any history of organ tissue transplantation Any history of blood product transfusion Current pregnancy Any condition that in the opinion of the Investigator should preclude the subject's participation in the study