Inclusion Criteria:  All participants  Signed informed consent must be obtained prior to participation in the study. Male and non-child bearing potential female participants, 18 to 75 years of age (inclusive), at Screening. Participants must weigh at least 50 kg to participate in the study, and must have a BMI within the range of 18.0 - 38.0 kg/m2, at Screening. Ability to communicate well with the investigator, to understand and comply with the requirements of the study.  Must be a non-smoker or agree to smoke no more than 5 cigarettes (or equivalent) per day from Screening until Study Completion.  Participants with mild HI (Group 2)  Participants must have a prior diagnosis of liver cirrhosis and mild HI as defined by the Child Pugh classification with a score of 5-6, inclusive (Class A) Participants have been clinically stable and had no worsening of more than 1 point in Child Pugh score within 1 month prior to dosing of study treatment.  Seated vital signs must be within the following ranges at Screening and Baseline:  Body temperature between 35.0 to 37.5°C, inclusive; Systolic blood pressure between 100 to 159 mmHg, inclusive; Diastolic blood pressure between 60 to 109 mmHg, inclusive; Pulse rate between 45 - 99 bpm, inclusive.  Participants with other stable medical disorders such as controlled diabetes, hyperlipidemia, hypothyroidism, etc., may be eligible as long as they are considered appropriate for enrollment as determined by the investigator by medical history, physical examination, ECG, and clinical laboratory tests at Screening.  Healthy control participants (Group 1)  Each participant must match 1:1 in gender, age (± 10 years), and body weight (± 15%) to a participant with mild HI.  Seated vital signs must be within the following ranges at Screening and Baseline:  Body temperature between 35.0 to 37.5°C, inclusive; Systolic blood pressure between 89 to 139 mmHg, inclusive; Diastolic blood pressure between 50 to 89 mmHg, inclusive; Pulse rate between 45 to 90 bpm, inclusive. Participants must be in good health as determined by medical history, physical examination, ECG, and clinical laboratory tests at Screening.  Exclusion Criteria:  All participants  Use of other investigational drugs within 5 half-lives or 30 days prior to dosing of study treatment, whichever is longer. History of hypersensitivity to the study treatment or its excipients or to drugs of similar chemical classes. Treatment with any oligonucleotide (with an exception for COVID 19 vaccines) or SiRNA within 9 months prior to Screening. Participants who received any COVID 19 vaccination and/or have not completed their full COVID-19 vaccination regimen within 14 days prior to Screening. Women of child bearing potential, defined as all women physiologically capable of becoming pregnant. Women are considered post-menopausal and not of child bearing potential if they have had 12 months of natural (spontaneous) amenorrhea with an appropriate clinical profile (e.g. age appropriate history of vasomotor symptoms) or have had surgical bilateral oophorectomy (with or without hysterectomy), total hysterectomy or bilateral tubal ligation at least 6 weeks prior to the first dosing. In the case of oophorectomy alone, only when the reproductive status of the woman has been confirmed by follow-up hormone level assessment is she considered not of child bearing potential. Sexually active males unwilling to use a condom during intercourse while taking study treatment and for 16 weeks after stopping study treatment. A condom is required for all sexually active male participants to prevent them from fathering a child AND to prevent delivery of study treatment via seminal fluid to their partner. In addition, male participants must not donate sperm for the time period specified above. Known history of, or current clinically significant arrhythmias, history of prolonged QT interval corrected by Fridericia's formula (QTcF), QTcF > 450 msec (males), or QTcF > 460 msec (females) at Screening. History of immunodeficiency diseases or have a positive HIV test result at Screening. History of malignancy of any organ system (other than localized basal cell carcinoma of the skin or in-situ cervical cancer), treated or untreated, within the past 5 years of Screening, regardless of whether there is evidence of local recurrence or metastases. Donation or loss of 400 mL or more of blood within 8 weeks prior to dosing of study treatment. Platelet count ≤ LLN at Screening or Baseline. History of unhealthy alcohol use within 12 months prior to dosing of study treatment, as defined by a recurring pattern of either binge drinking (≥ 5 drinks over 2 3 hours on ≥ 5 days/month) or heavy drinking (≥ 8 drinks/week in females or > 15 drinks/week in males). A "drink" definition includes: 12 ounces of 5% beer, 8 ounces of 7% malt liquor, 5 ounces of 12% wine or 1.5 ounces of 40% spirits. Positive alcohol screen at Screening or Baseline. History of drug abuse within the last 12 months or evidence of such abuse as indicated by the laboratory assay conducted during Screening or Baseline, unless the positive drug screen is due to prescription drug use that is approved by the investigator and Novartis. Clinically significant illness (other than HI for participants in Group 2) within 2 weeks prior to dosing of study treatment that may jeopardize safety of the participant and/or alter the study results as judged by the investigator. Significant glomerular disease (including but not limited to IgA nephropathy, diabetic nephropathy, systemic lupus erythematosus, etc.) with urinary protein-creatinine ratio > 500 mg/g (56.6 mg/mmol). Any surgical or medical condition which might significantly alter the absorption, distribution, metabolism, or excretion of drugs (apart from cholecystectomy), or which may jeopardize the participants in case of participation in the study. The investigator should make this determination in consideration of the participant's medical history. Have tattoo(s) or scarring at or near the site of injection or any other condition which may interfere with injection site examination, in the opinion of the investigator.  Unwillingness or inability (e.g. physical or cognitive) to comply with study procedures, study treatment administration (i.e. injection), or schedule.  Participants with mild HI (Group 2)  Presence of any non controlled and clinically significant disease that could affect the study outcome or that would place the participant at undue risk. Severe complications of liver disease within the preceding 3 months of Screening. Have received liver transplant at any time in the past. Participants requiring paracentesis more than every 30 days for the management of ascites. Participants who are receiving diuretics to manage ascites may be enrolled and will be assigned the Child Pugh score for the degree of ascites while on diuretic treatment. The diuretic dose must have been stable for at least 14 days prior to dosing of study treatment. Have transjugular intrahepatic portosystemic shunt and/or have undergone portacaval shunting. Have acute hepatitis B or C infection at Screening or active infection requiring therapy that will not be completed before Screening. Presence of moderate to severe impaired renal function as indicated by estimated glomerular filtration rate < 45 mL/min/1.73 m2 based on MDRD calculation. Hemoglobin levels below 10.0 g/dL at Screening or Baseline. Have encephalopathy Grade 3 or worse within 28 days prior to dosing of study treatment. Have primary biliary cholangitis or biliary obstruction. History of gastrointestinal bleeding within the past 3 months prior to Screening.  Clinically significant abnormal findings in physical examination or clinical laboratory evaluations not consistent with known liver disease.  Healthy control participants (Group 1)  Any single parameter of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl-transferase (GGT), or alkaline phosphatase (ALP) exceeding 1.2 x upper limit of normal (ULN), total bilirubin ≥ 1.5 x ULN, or any elevation above ULN of more than one parameter of ALT, AST, GGT, ALP, or total bilirubin at Screening or Baseline. Hemoglobin levels more than 10% below LLN at Screening or Baseline. Participants known to have Gilbert's syndrome. Chronic hepatitis B or hepatitis C infection. A positive HBsAg test, or if standard local practice, a positive hepatitis B virus core antigen test, is an exclusion. Participants with a positive hepatitis C virus (HCV) antibodies (Ab) test should have HCV ribonucleic acid (RNA) levels measured. Participants with positive (detectable) HCV RNA should be excluded. Are taking medications prohibited with the study treatment (see Section 6.2.2 for additional details on prohibited medication) or herbal supplements, prescribed medicinal use of cannabis/marijuana, within 14 days prior to dosing of study treatment. Impaired renal function as indicated by clinically significantly abnormal creatinine or blood urea nitrogen and/or urea values, or abnormal urinary constituents at screening and/or baseline.