Inclusion Criteria:  Able and willing to provide a written informed consent Males and females aged between 18 years and 55 years at screening, inclusive. Meet the weight standard Agree to take effective contraceptive methods No clinically significant abnormalities in medical history, general physical examination, vital signs, laboratory tests  Exclusion Criteria:  Severe infections, injuries or surgeries or plan to undergo any surgeries. ALT, AST, ALP or total bilirubin level abnormal Estimated Glomerular Filtration Rate (eGFR, using CKD-EPI Creatinine Equation) is abnormal Subject's supine systolic BP is >140 mmHg or <90 mmHg; diastolic BP >90 mmHg or <40 mmHg at screening/baseline visits or before dosing. Subjects with cardiac and Cerebrovascular Disease Positive nicotine test History of regular alcohol consumption in the past 1 month exceeding an average weekly intake of 21 standard drinks Positive drug screening tests Positive infectious diseases screening tests plan to use of any other medicine during the trial Whole blood donation or loss of more than 200 mL of blood within 1 month blood transfusion in the past 2 months History of allergy to the study drug or any component of it. Can't accept assigned meals during the trial Treatment with an investigational drug within 30 days (or 5 half-lives, whichever is longer) of dosing. poor tolerance or difficult for vein blood collection Other conditions or laboratory abnormality that may increase the risk associated with study participation