Inclusion Criteria:  Age during 18-85 years old Arteriovenous fistula is matured and has undergone one or more hemodialysis sessions Venous stenosis of the AV fistula target lesion has stenosis ≥50% evidenced by angiography. and have at least one symptom of these：1,the venous pressure increased significantly during dialysis. 2,abnormal physical examination. 3,Decrease in blood flow the length of target lesion ≤100mm Patient able to give informed consent residual stenosis ≤30% after predilation  Exclusion Criteria:  Women who are breastfeeding, pregnant or are intending to become pregnant AVF located at lower limbs Two or more than two stenosis at the target vessel. Obstruction of central venous return ISR AVF with acute thrombosis requiring lysis or thrombectomy in 30 days Vascular access has surgery in 30 days or intending to undergo a surgery Known hypersensitivity to aspirin, heparin, clopidogrel,paclitaxel, contrast medium, etc. Patients undergoing immunotherapy or suspected / confirmed vasculitis Patients with history of blood coagulation dysfunction and history of thrombocytopenic purpura Vascular access infection or systemic active infection Patients's life expectancy is less than 12 months Renal transplantation has been planned or converted to peritoneal dialysis Other medical conditions that lead to researchers who believe that patients may not be able to follow the trial program Involved in other drugs, biology, medical device research, or has been involved in other similar products clinical Test