Inclusion Criteria:  People (aged ≥18 years) Clinical signs and symptoms of pulmonary TB including cough ≥2 weeks and ≥1 other symptom typical of pulmonary TB (fever, malaise, recent weight loss, night sweats, hemoptysis).  Exclusion Criteria:  Absence of informed consent (Unwilling or unable to provide informed consent) Insufficient sample volume or number, Receipt of any dose of TB treatment within six months prior to enrolment. Unwilling to provide two sputum specimens at enrolment Patients with only extra-pulmonary TB signs & symptoms