Inclusion Criteria:  Patients with suspected primary RCC with planned surgery (cohort 1) or patients with tissue-confirmed metastatic ccRCC with a site accessible for biopsy (cohort 2). (In standard clinical practice, biopsy is not routinely performed in patients who will be having surgery). Ability to understand and the willingness to sign a written informed consent that includes study interventions (PET/CT and, if cohort 2, mandatory biopsy). Ability to lie still for a 30- to 60-minute PET/CT scan.  One of the following:  Cohort 1. Patients with suspected RCC planned for surgery. Cohort 2. Patients with metastatic ccRCC.  Women of child-bearing potential must agree to undergo and have documented a negative pregnancy test on the day of [18F]PT2385 administration. A female of child-bearing potential is any woman (regardless of sexual orientation, having undergone a tubal ligation, or celibate by choice) who meets the following criteria:  Has not undergone a hysterectomy or bilateral oophorectomy; or Has not been naturally postmenopausal for at least 12 consecutive months (i.e., has had menses at any time in the preceding 12 consecutive months).  Exclusion Criteria:  Uncontrolled severe and irreversible intercurrent illness or psychiatric illness/social situations that would limit compliance with study requirements. Subjects must not be pregnant or nursing due to the potential for congenital abnormalities and the potential of this regimen to harm nursing infants. Claustrophobia or other contraindications to PET/CT. Subjects must not weigh more than the maximum weight limit for the table for the PET/CT scanner where the study is being performed (>200 kilograms or 440 pounds). For cohort 2 patients, lack of suitable sites for mandatory biopsy. For example, patients with metastatic disease restricted to the lungs that would require percutaneous biopsies with associated risk of bleeding and pneumothorax will be excluded.