Inclusion Criteria:  age, 19-45 years; infertility, 2 years; regular sexual intercourse with a fertile female. The female partner was defined as being fertile if she had undergone a negative infertility workup (biphasic basal body temperature, P evaluation in luteal phase, ultrasound ovary and uterus evaluation, and hysterosalpingogram to study tubal patency)  Exclusion Criteria:  use of antioxidant agents or vitamins within 8 weeks prior to inclusion in the study, a history of excessive consumption of alcohol 40 days prior to the start of the trial, patients that showed lower than 5% motility and less than 1 × 106/ml sperm concentration, - patients with any acute or chronic disease or who are undergoing some kind of treatment with any class of drugs and subjects with known hypersensitivity to ingredients in the antioxidant formula.