Inclusion Criteria:  age 18-60 years old who are newly diagnosed with ovarian cancer based on histopathology epithelial ovarian cancer stage II-III haven't received chemotherapy pre-cachexia or cachexia level of vitamin D below 30 ng/ml no vitamin D allergy ability and willingness to understand and provide informed consent  Exclusion Criteria:  autoimmune disease chronic liver disease chronic renal disease known had hypercalcemia refractory cachexia