Inclusion Criteria:  Inpatients or outpatients greater than or equal to 18 years old Capable of providing informed consent Undergoing bronchoscopy for diagnosis or staging per standard of care Collection of small biopsy samples by EBUS or conventional transbronchial needle aspiration (TBNA) or transbronchial biopsy for purposes outside of the research study  Exclusion Criteria:  Standard contraindications bronchoscopy including bleeding disorders, antiplatelet or anticoagulant usage, severe respiratory failure, and clinical instability Pregnancy