Inclusion Criteria:  stage 3 or 4 of head and neck cancer or nasopharyngeal cancer with pathological confirmed malignancy undergoing concurrent chemoradiotherapy more than 20 times or radiation dermatitis > CTCAE grade 2. more than 18 years old. VAS score > 6 with poor response to narcotics. estimated survival time of > 6 months. be suitable for TCM topical treatment after evaluation by TCM physicians. willingness to joint this trial and sign consent form of study.  Exclusion Criteria:  non-head and neck cancer or have not receive CCRT. not be suitable for Ru-Yi-Jin-Huang topical treatment after TCM physicians evaluation. history of allergy to TCM topical use. poor conscious to answer questionnaires. pregnancy. KPS < 30.