Inclusion Criteria:  age > 18 years old; acceptance of written informed consent to undergo an endoscopic bariatric therapy; I and II grade obesity: BMI 30-34.99 with many failed attempts at noninvasive weight loss and with obesity-related diseases; BMI 35-39.99 with many failed attempts at noninvasive weight loss.  Exclusion Criteria:  coagulation problems (such as platelet < 30000, INR >1.8), chronic kidney disease, heart disease; any other contraindication for endoscopic bariatric procedure; patients who do not give their consent to the enrollment in the study or are incompetent, unconscious or unable to express their consent for any reason; patients suffering from any condition which precludes compliance with study instructions; patient has any allergy or other known contraindication or intolerance to the medications used in the study for the preparation; women who are either pregnant or nursing at the time of screening, or are of child-bearing potential and do not practice acceptable methods of contraception; patient suffers from a life threatening condition.