Inclusion Criteria:  At least 18 years of age, male or female, of any race Provide written consent and sign a HIPAA form Willingness and ability to follow all instructions and comply with schedule for follow-up visits For females: must not be pregnant  Having topographic evidence of keratoconus which is graded as moderate or severe keratoconus defined as the following:  Moderate Keratoconus: Axial topography consistent with keratoconus, Maximum keratometry on Pentacam greater than or equal to 51.01 D Severe Keratoconus: Axial topography consistent with keratoconus with marked areas of steepening, Maximum keratometry on Pentacam greater than or equal to 56.01 D Presence of central or inferior steepening on the Pentacam map BSCVA less than or equal to 20/25 Contact lens wearers only: remove contact lenses one week prior to the screening refraction  Exclusion Criteria:  Contraindications, sensitivity or known allergy to the use of the test article(s) or their components If female, be pregnant Eyes classified as either normal, atypical normal, keratoconus suspect or mild keratoconus on the severity grading scheme  Previous ocular condition (other than refractive error) in the eye to be treated that may predispose the eye for future complications. For example:  a) History of corneal disease (e.g., herpes simplex, herpes zoster keratitis, corneal melt, corneal dystrophy, etc.)  A history of delayed epithelial healing in the eye to be treated Have used an investigational drug or device within 30 days of the study or be concurrently enrolled in another investigational drug or device study within 30 days of the study