Inclusion Criteria:  clinical diagnosis of cirrhosis Portal hypertension with esophageal variceal bleeding diagnosis of PVT by imaging examination undergo variceal band ligation  Exclusion Criteria:  liver cancer or other tumors cavernous transformation of portal vein creatinine more than 20mg/dL，platelet count lower than 10*10^9/L ongoing antithrombotic treatment or have received thrombolytic treatment pregnancy or breastfeeding Having contraindications for endoscopic therapy Severe heart and lung diseases，uncontrolled massive hemorrhage or general infection major surgery within 3 months primary thrombophilia, Budd-Chiari syndrome Having received endoscopic therapy, transjugular intrahepatic portosystemic shunt (TIPS) or liver transplantation before