Inclusion Criteria:  Adult, age >= 18 Patients with resectable hepatocellular carcinoma  Exclusion Criteria:  Females who are pregnant or attempt to become pregnant Patient with significant anemia (hemoglobin [Hb] < 7g/dL) Patient has known cancer outside of the liver 5 years prior to current blood collection (not including basal cell or squamous cell skin cancers) Patient has had a biopsy to the target organ and/or lesion within 3 days before blood collection Patient has had an intervention to completely remove current target pathology