Inclusion Criteria:  provision to sign and date the consent form. stated willingness to comply with all study procedures and be available for the duration of the study. Male and female patients aged 18 and older Benign or malignant colorectal disease undergoing laparoscopic, robotic, or a "hybrid" (minimally invasive dissection with a 6-8 cm incision to complete the surgery) colorectal resection with or without an ostomy  Exclusion Criteria:  Pregnant or breastfeeding patients Medical conditions that may interfere with the use of the study medications (e.g., drug allergy), Patients with opioid dependence defined as chronic opioid use more than 3 times per week preoperatively Incarcerated individuals Age less than 18 years-old Urgent/emergent operations as defined by need for operation within 24 hours Other conditions or general disability or infirmity that in the opinion of the investigator precludes further participation in the study. Enrollment in another concurrent study with use of investigational drugs