Inclusion Criteria:  Ages 2-25 at time of consent Subject has newly diagnosed cancer per Investigator, and is planning to undergo chemotherapy for treatment of malignancy Ability of subject (and/or parent/guardian) to read and understand the English or Spanish language Subject is anticipated to receive at least 3 months of chemotherapy or other cancer treatment. As determined and documented by the enrolling investigator, ability of the subject to understand and comply with study procedures for the entire length of the study  Exclusion Criteria:  Known cardiac dysfunction that, in the opinion of the investigator, would be unsafe for the child to participate in the exercise program Recent (within 4 weeks of enrollment) or planned surgery that will result in prolonged limited mobility not amendable to exercise modifications per investigator discretion Primary CNS Tumor Osteosarcoma