Inclusion Criteria:  Age ≥ 18 years Written informed consent NSTI/NF of the lower limb clinically suspected and confirmed by surgery with a first debridement performed since 5 days or more Infection considered controlled (i.e., no more surgical debridement is necessary) Last debridement performed at least 72 hours before Affiliation to a social security system  Exclusion Criteria:  Limited life expectancy NPWT already initiated for the current NSTI/NF episode 1st surgical debridement performed less than 5 days or more than 15 days before High risk of bleeding (blood vessels exposed) Local neoplasia Risk of organ or peripheral nerve injury Impossibility to set up a NPWT dressing hermetically Limb amputation Patient unable to walk without help Women who are pregnant or are breast-feeding, or are of childbearing age and do not use or do not plan to use acceptable birth control measures Patients under legal protection Prisoners