Inclusion Criteria:  > 18 years Refractory acidosis (pH<7.2 or HCO3<15) Refractory volume overload Refractory hyperkalemia (K>6.2mEq/L or EKG change) Anuria or oliguria (urine output <0.5 mL/kg/hr for 6-12hr) High BUN >100 mg/dL or uremic symptom Increase intracranial pressure  Exclusion Criteria:  Pregnancy Not use heparin in ECMO Chronic kidney disease with CRRT AKI with Glomerulonephritis, Interstitial nephritis, Vassculitis or Urinary tract obstruction