Inclusion Criteria:  Male or female 18 years of age or older, with documented full, written informed consent Requiring cardiothoracic (CT) surgery with cardiopulmonary bypass (CPB) within 48hrs of last ticagrelor intake  Exclusion Criteria:  >48hrs between last ticagrelor dose and start of CT surgery Heart-lung transplant procedures Procedures for ventricular assist device Underlying bleeding diathesis Prohibited concomitant antithrombotic medications as defined in the study protocol Acute sickle cell crisis Known allergy to device components Active (untreated) systemic infection History of major organ transplantation and those currently receiving immunosuppressive medication or who are profoundly immune suppressed Women with positive pregnancy test during current admission or who are lactating Life expectancy <30 days Inability to comply with requirements of the study protocol Treatment with investigational drug or device within 30 days of current surgery Previous enrollment in this trial