Inclusion Criteria:  Age >= 18 years of age Surgically resected stage III melanoma with no evidence of disease according to the American Joint Committee on Cancer (AJCC) classification criteria Eligible for adjuvant CPI treatment per treating physician discretion Plan to continue care, including CPI infusions, at MD Anderson Cancer Center (MDACC) Ability to communicate and read in English language  Exclusion Criteria:  Previous systemic therapy for melanoma  Previous history of other cancer  Note: Participants with basal cell carcinoma of the skin, squamous cell carcinoma of the skin, or carcinoma in situ (e.g., breast carcinoma, cervical cancer in situ) that have undergone potentially curative therapy are not excluded Previous history of inflammatory or autoimmune diseases. This include but not limited to systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, vascular thrombosis associated with antiphospholipid syndrome, Wegener's granulomatosis, Sjogren's syndrome, Guillain-Barre syndrome, multiple sclerosis, autoimmune thyroid disease, vasculitis, type I diabetes mellitus, psoriasis, or vitiligo Other concurrent malignancies that require active therapy Participants < 18 years of age and pregnant women are not eligible to participate in this study