Inclusion Criteria:  Male subjects aged >= 45 years old Histologically confirmed diagnosis of prostate cancer Subjects must have completed radiation therapy >= 2 months, but =< 6 years prior to registration Subjects undergoing androgen depravation therapy with serum testosterone levels < 20 ng/ml Subjects who have a score > 25 on the Brief Fatigue Inventory (BFI) at screening Subjects who are fluent in speaking and reading English  Based on International Classification of Diseases (ICD)-10 proposed criteria, the patient must have a diagnosis of CRF with evidence from the history, physical exam, and laboratory findings that the fatigue is a consequence of cancer or cancer therapy and not primarily a consequence of any of the following:  Comorbid psychiatric disorders Anemia (hemoglobin less than 10 g/dl) Hypothyroidism (thyroid stimulating hormone (TSH) greater than 4.6 micro-international units (uIU)/mL) Uncontrolled pain  Any medical or psychiatric condition or medication felt to be clinically contributing to fatigue based on the investigator's history, physical examination, and assessment. These medical circumstances may include:  The use of medications such as opioids, sedating anti-histamines, or neuroleptics; Medical problems associated with fatigue: chronic obstructive pulmonary disease, congestive heart failure, renal disease, hepatic dysfunction, uncontrolled autoimmune disease, neurological disorders such as multiple sclerosis or Parkinson's disease, and sleep apnea Able to provide informed consent and willing to sign an approved consent form that conforms to federal and institutional guidelines  Exclusion Criteria:  Inability to lay supine for one hour at a time, given the nature of the massage intervention Body-mass index less than 18.5 (kg/m^2) Treatment with corticosteroids or other immunosuppressants =< 6 months prior to registration Subjects who have completed radiation >= 6 years prior to registration Subjects who cannot comply with the protocol for any reason Regular use of anti-inflammatory drugs including non-steroidal anti-inflammatory drugs and natural products thought to have anti-inflammatory properties Use of medications for anxiety or depression =< 4 weeks prior to registration. (psychotropic drug free for at least 4 weeks - 8 weeks for fluoxetine) Use of fluoxetine within =< 8 weeks prior to registration Subjects meeting criteria for a current substance use diagnosis or current diagnoses of schizophrenia, depression, generalized anxiety disorder, bipolar disorder, dementia, delirium, or obsessive compulsive disorder (OCD) Subjects who are actively suicidal or homicidal  Other conditions or behaviors that, in the opinion of the treating investigator, may negatively impact study participation, including the following:  Illicit drug use Shift work Current dieting Excessive regular use of alcohol (more than two 5-ounce glasses of wine or equivalents/day) Any instance of binge drinking (more than 7 drinks in a 24-hour period) =< 6 months prior to registration Subjects who have used massage as a therapeutic modality (medical or psychological) for the treatment of medical conditions Subjects who have had 4 or more massages a year for the last 5 years  Current use of complementary or alternative medicine (CAM) manual therapy and/or holistic therapies to treat a perceived health problem.  Subjects who have engaged in a CAM manual therapy in the past will not be excluded. Subjects who practice yoga or meditation for well-being, take vitamins, or use nicotine will not be excluded Medical, psychiatric, cognitive, or other conditions that may compromise the subject's ability to understand the subject information, give informed consent, comply with the study protocol, or complete the study