Inclusion Criteria:  Diagnosis of sickle cell disease (HbSS, HbSC, HbSB0 thalassemia, HbSB+ thalassemia, HbS/Other) Has not received any COVID-19 vaccination prior to enrollment Scheduled for a COVID-19 vaccination (type does not matter) as part of routine clinical care Willing and able to sign consent  Exclusion Criteria:  Unwilling to have labs drawn or complete study requirements. Previous therapy curative of SCD (including bone marrow transplant and gene therapy) Previous receipt of anti-COVID-19 antibody therapy