Inclusion Criteria:  Consecutive adult patients (≥ 18 years) with septic shock according to Sepsis-3 consensus conference (septic shock defined as suspected or confirmed infection, plus hyperlactatemia and NE requirements due to persistent hypotension, after a fluid load of at least 1000 mL in one hour)  Exclusion Criteria:  More than 4 hours since septic shock diagnosis, Anticipated surgery or acute hemodialysis procedure to start during the 6h intervention period Active bleeding, Do not resuscitate status, Child B-C Cirrhosis Underlying disease process with a life expectancy < 90 days and/or the attending clinician deems aggressive resuscitation unsuitable Refractory shock (high risk of death within 24h) Pregnancy Concomitant severe acute respiratory distress syndrome. Patients in whom CRT cannot be accurately assessed.