Inclusion Criteria:  adult patients (18 years or older), both sexes Sars-CoV-2 infection confirmed by PCR less than 4 days before randomization hospitalized with a diagnosis of SARS-CoV-2 pneumonia radiographic evidence of pulmonary infiltrates grade 4 or 5 on the ordinal scale for the evaluation of the patient's clinical condition pO2/FiO2 <380 men and women of childbearing age who have heterosexual relations must be agreement to use the safe method(s) of contraception obtaining the informed consent of the patient or the legal representative.  Exclusion Criteria:  imminent death (life expectancy less than 72h) known hypersensitivity or known adverse reactions to the study drug, or its metabolites or excipients of the formulation invasive mechanical ventilation participation in any other clinical trial ALT or AST > 5 x ULN creatinine clearance <50 mL/min using the Cockcroft-Gault formula for participants '18 years old [Cockcroft 1976] patients with recent acute coronary syndrome (<1 month) patients with a history of stroke positive pregnancy test pregnant or lactating woman