Inclusion Criteria:  Patients 18 years old or older with an ischemic de-novo lesion(s) in a 2.5 - 4.0 mm reference diameter coronary artery suitable for elective percutaneous coronary intervention, in context of acute coronary syndrome or chronic coronary syndrome with evidence of ischemia by non-invasive study or pressure guidewire that can be treated by DEB or DES, and has at least 1 major or 2 minor Academic Research Consortium High Bleeding Risk criteria:  Major criteria:  Anticipated use of long-term oral anticoagulation Severe or end-stage CKD (eGFR <30 mL/min) Hemoglobin < 11 g/dL Spontaneous bleeding requiring hospitalization or transfusion in the last 6 months, or any time, if recurrent. Moderate or severe baseline thrombocytopenia (<100,000/uL) Chronic bleeding diathesis Liver cirrhosis with portal hypertension Active malignancy (excluding nonmelanoma skin cancer) within the past 12 months Previous spontaneous intracranial hemorrhage Previous traumatic intracranial hemorrhage within the past 12 months Presence of Brain arteriovenous malformation (AVM) Moderate or severe ischemic stroke (NIHSS score equal or more than 5) within the past 6 months Non deferrable major surgery while on DAPT Recent major surgery or major trauma within 30 days before PCI  Minor Criteria:  Age 75 years old and older Moderate Chronic Kidney Disease (CKD) (eGFR 30-59 mL/min) Hemoglobin 11 - 12.9 g/dL in men and 11 - 11.9 g/dL in women Spontaneous bleeding requiring hospitalization or transfusion within the past 12 months, not meeting major criterion Long term use of NSAIDs or steroids Any ischemic stroke at any time not meeting major criterion  Exclusion Criteria:  STEMI undergoing primary PCI Any ACS undergoing urgent PCI Cardiogenic shock or resuscitation with uncertain neurological status at arrival to PCI Unprotected left main lesion Life expectancy < 12 months Reference vessel diameter < 2.5 mm or > 4.0 mm Bifurcation lesion requiring 2-stent technique Chronic total occlusion In-stent restenosis Dissection affecting the flow (TIMI<3) or significant recoil (>30% in main branch, >50% in side branch) after predilatation Inability to give written consent