The inclusion criteria:  Patients were age older than or equal to 18 years Patients with medium and high Framingham risk score，namely, Framingham Risk Score (FRS) 10%-20%,or FRS > 20%. All participants gave written informed consent to this study, which was approved by the ethics committee of Tongji University.  Exclusion Criteria:  Patients were suffering from mental illness. Life expectancy of patients were less than 1 year.