Inclusion Criteria:  Patients older than 18 years. Diagnosis of locally advanced head and neck cancer (oral cavity, oropharynx, hypopharynx, larynx), stage III-IVB. Proposed for primary treatment with curative intent - surgery or induction chemotherapy before chemoradiotherapy (CRT) or CRT alone.  Exclusion Criteria:  Synchronous tumors or other comorbidities with associated uncontrolled symptoms. Inability to provide informed consent. Expected inability to fulfil the propose schedule and follow-up.