Inclusion Criteria:  Subject is between 40 and 80 years of age inclusive;  Menopausal women (with or without hysterectomy) must also meet 1 of the following 3 conditions:  A Non-hysterectomy, menopause ≥ 12 months; B. Menopause > 6 months and < 12 months or premenopausal hysterectomy, follicle stimulating hormone (FSH) > 40 IU/L; C ≥ 6 months since baseline assessment (Day 1) with or without hysterectomy.  At screening and baseline (Day 1), the subject presented with moderate-severe dyspareunia (dyspareunia) as measured by the Vaginal Atrophy Symptom Questionnaire (VASQ) and self-rated as the most bothersome symptom. ≤ 5% superficial cells by vaginal smear at screening and baseline (Day 1). Vaginal pH > 5 at Screening and Baseline (Day 1). Women (with or without a partner) who currently have sex or other sexual activity (masturbation, etc.) at least once a month, or who have sex or other sexual activity at least once a month in the past, with reduced sexual activity due to excessive pain or vaginal dryness. Normal physical examination of the breast and normal mammographic findings (BI-RADS grade 1 or 2) within 9 months prior to the baseline visit (Day 1). Normal cervical smear results (including inflammatory changes), regardless of hysterectomy (no abnormal cervical smear in the past 2 years if ASCUS is present, and human papillomavirus (HPV) test negative can be used) within 12 months before the baseline visit (Day 1).  Voluntarily participate in this clinical trial and sign the informed consent form (ICF).  -  Exclusion Criteria:  Patients with a history of malignant tumor. Have active or history of thromboembolic disease (excluding thromboembolic events due to accidents, surgery, immobilization). Clinically significant endocrine metabolic disease (e.g., diabetes mellitus) not controlled with medication. Use of estrogen injections, estrogen implant sticks, progestogen injections, progestogen implants, androgens, anabolic steroids within 6 months of the screening visit. Use oral estrogen, oral progesterone, prasterone (DHEA) or intrauterine progesterone treatment, intravaginal hormonal drugs (ring, cream, gel or tablet), estrogen alone or estrogen/pregnancy within 8 weeks before the screening visit, hormone transdermal drug users. Confirmed depression with poor control under standard treatment or history of diagnosed psychiatric disorder. Those who have participated in or plan to participate in other drug or device clinical trials during the study period within 1 month prior to the screening visit. Laboratory findings suggestive of glutamic-pyruvic transaminase (ALT), glutamic oxaloacetic transaminase (AST) ≥ 2 times the upper limit of normal, or creatinine ≥ 1.5 times the upper limit of normal. Grade 2 and higher uterine prolapse (cervix reaching labia minora). Transvaginal ultrasound revealed a uterine fibroid ≥ 3 cm in diameter. Endometrial thickness ≥ 4 mm by transvaginal ultrasound, or other comprehensive assessment by the investigator with the possibility of endometrial hyperplasia, deterioration. Current endometrial polyps. Previous endometrial ablation. Patients with vulvar lichen sclerosus. Patients with unexplained vaginal bleeding. Patients who are known to be allergic to the study drug or its ingredients. Patients who have participated in other relevant clinical trials of the investigational drug (prasterone vaginal suppositories). History of past or present drug or alcohol abuse (14 units of alcohol per week: 1 unit = 285 mL of beer, or 25 mL of spirits, or 100 mL of wine).  Subjects who are unable to perform the procedures required by the protocol, or any other subjects who are not suitable for this clinical study judged by the investigator.  -