Inclusion Criteria:  Age ≥18 years and < 80 years Patient with a medically unbalanced partial epilepsy Patient with a lesional image(s) in morphological MRI responsible for epilepsy based on clinical and electrophysiological assessment, +/- PET +/- SPECT +/- MEG +/- sEEG Patients for whom scheduled neurosurgical treatment with craniotomy appears difficult: Deep lesions, eloquent region lesions, patient reluctance to perform surgery. Endorsement of the Multidisciplinary Meeting of Neuro-epileptology Patient affiliated with a social security scheme Patient who has signed prior, free and informed consent  Exclusion Criteria:  Pharmacosensitive epilepsy Patient with poor adherence to medication, or with psychological disorders Patients under legal protection Patient with a contraindication to MRI (metal shards, known allergy to gadolinium, etc.) Anticoagulant and antiplatelet therapy underway, cannot be stopped. Severe and unbalanced psychiatric disorders Pregnant women. Women of childbearing age should use oral contraception throughout the study. Allergy to local anaesthetics / general anaesthesia