Inclusion Criteria:  -  Healthy subjects:  Voluntarily sign the informed consent form, understand the trial procedures, and be willing to comply with all trial procedures and restrictions; 18 ≤ age ≤45, male; Subjects with weight ≥50.0 kg and body mass index (BMI) 19-26 kg/m^2 (inclusive); Subjects are willing to use effective non-hormonal contraceptives such as sexual abstinence, and not allowed to donate sperm from screening to the 6 months after the last dose administration unless permanent contraception has been taken, such as vasectomy; Ability to communicate well with researchers, and be willing to comply with all trial requirements.  Exclusion Criteria:  Allergic constitution, including a history of allergy to any of the study drugs or other similarly structured drugs; Previous or current severe diseases, such as cardiovascular, respiratory, gastrointestinal, endocrine, hematological, psychiatric/neurological systems diseases, or any other disease that can interfere with the results of the study; Subjects with sleep apnea syndrome; Subjects with rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption; Subjects with acute angle closure glaucoma; Subjects who have previously undergone surgery that may affect the absorption, distribution, metabolism, or excretion of the drug (e.g., subtotal gastrectomy), or who have a scheduled surgical plan during the study period; Use of any inhibitors or inducers of CYP3A4, or any strong inhibitors or inducers of CYP2C8 or P-gp within 2 weeks prior to screening; Use of any prescription drug, over-the-counter drug, herbal medicine or health products within 2 weeks prior to screening; History of drug abuse within 1 year prior to screening, or positive urine drug screen at screening; Smoking more than 5 cigarettes per day within 6 months prior to screening; Average daily intake of alcohol more than 14 units (14 units ≈285 mL of beer, or 25 mL of liquor, or 150 mL of wine) within 4 weeks prior to screening, or a positive ethanol breath test at screening; Consumption of grapefruit juice, methylxanthine-rich food or beverage (such as coffee, tea, cola, chocolate, energy drinks) within 48 h before the administration, or those who have had strenuous exercise, or have other factors affecting absorption, distribution, metabolism, excretion, etc of the drug; Subjects who have received vaccinations within 4 weeks prior to screening; Participation in another clinical trial within 3 months before screening (whichever is administrated); Blood donation (or blood loss) ≥200 mL within 4 weeks prior to the screening, or who have a blood donation plan during the entire study or within 1 months after the study; Any abnormalities of clinical significance in physical examination, vital signs, clinical laboratory tests (routine blood test, blood biochemistry, routine urine test, coagulation function), anteroposterior chest radiograph or chest CT scan; Abnormalities of clinical significance in 12-lead ECG examination (such as tachycardia/bradycardia in need of medical treatment, II-III degree atrioventricular block, QTcF>450 ms or any other clinically significant abnormalities); Any positive test result of hepatitis B surface antigen or hepatitis C virus antibody, or subjects with a history of hepatitis B; Any positive test result of anti-human immunodeficiency virus antibody or anti-Treponema pallidum specific antibody; Subjects with a history of fainting needle or blood, cannot tolerate vein puncture for blood collection; Any condition that, in the opinion of the Investigator, may prevent the subject from completing the study or pose a significant risk to the subject.