Inclusion Criteria:  Male or female subjects, 18 to 85 years of age at the time of enrollment. Subject has Diabetes Mellitus (type 1 or type 2) by WHO criteria. Wounds in which a decision to treat it with Negative Pressure Wound Therapy (NPWT) has been made due to the wound condition and the physician practice (the wound should be one that deem suitable to NPWT treatment). In the case of wounds involving the plantar aspects, they should be without significant bony prominences (unless off-loading can effectively relieve these pressure areas). The wound does not have overt signs of infection or if there is residual infection, it is under control and in the process of resolving as evidenced by laboratory tests (within one day prior to study commencement for in-house patients) and clinical judgment. The wound type configuration and location clearly allows the application of VAC with efficient sealing. If there are additional wounds in the same foot that can be connected by the same VAC apparatus, then each wound will be considered as an index wound and analyzed separately. If there are additional wounds that cannot be connected by the VAC apparatus, the criteria to include the patient in the study is that these wounds can be dressed separately and not interfere with the VAC apparatus. These wounds will be treated by SOC and will not be included in the statistical analysis.  Vascular assessment:  All patients need to have ankle-brachia index (ABI) determination even in the presence of palpable pulses. If ABI is > 0.5 in both arteries, or >0.8 in at least one artery, the patient will be eligible to participate in the study. Patients in whom reliable ABI cannot be obtain due to non-compressible arteries, toe-brachial index (TBI) will be assessed and it needs to be > 40. Patients who have undergone successful vascular intervention will be assessed by ABI measurements. Nevertheless, if in such patients the value will negate participation in the study, vascular surgeon consultation or interventional radiologist report on good outcome during the procedure will allow inclusion in the study. Having a body mass index (BMI) <45 Kg/m2. Recent glycosylated haemoglobin (HbA1c) <12.0%. Recent creatinine level ≤3.0 mg/dL. No further surgery to handle the wound or the infection is expected or contemplated. The patient is able and eligible to sign written informed consent and participate in the study. Be available for the entire study period, and ability and willingness to adhere to the requirements of the study.  Exclusion Criteria:  General conditions:  Unstable cardiac disease or other medical conditions with expected repeated hospitalizations during the study phase. Participation in an investigational trial (active phase) at the time of study inclusion. History of allergic reactions attributed to copper; Wilson disease. Any patients receiving or expected to receive chemotherapy during the study period. Any form of substance abuse (including drug or alcohol abuse, excluding cannabis), psychiatric disorder or any chronic condition susceptible, in the opinion of the investigator, of interfering with the conduct of the study. Females who are pregnant, lactating, of child-bearing potential. Fertile female subjects who are not willing to use an acceptable method of contraception during the treatment period and for 14 days following completion of treatment. Subjects who are likely to be non-compliant or uncooperative during the study. Subjects and conditions in which a non-approval of VAC therapy (usually be the HMO) is expected or suspected.  Laboratory tests:  Anemia (Hemoglobin < 7.0 g/dL). BMI > 45 Kg/m2. White Blood Cells count > 12,000/μL (higher levels are affordable if clinical improvement and other laboratory signs of improvement are evident). Platelet's count < 75,000/μL. Albumin < 2.0 g/dL. CRP - may be higher than normal but should be stable at the time of enrollment or a with a trend toward improvement. Blood Creatinine > 3.0 mg/dL at the time of enrolment. Any other clinically significant blood and urinalysis tests abnormalities that can jeopardize study results as evaluated by the investigator.  Wound condition:  Any signs of active or residual infection of the wound that need close inspection and/or repeated debridement. Wounds that deem unsuitable to NPWT treatment due to expected problem of sealing the wound (e.g. wound with toe clefts) or too painful to handle such treatment.