Inclusion Criteria:  Age > 18 years old Histological or cytological documentation of squamous cell carcinoma. Primary tumor location in nasopharynx Previous, documented failure on platinum-based chemotherapy or progression of the disease during platinum-based chemotherapy Tumor recurrence (local or nodal) or generalization (metastasis) occurence during or within 6 months after previous platinum-based chemotherapy ECOG(Eastern Cooperative Oncology Group) performance scale 0-1 Participant is willing and able to give informed consent for participation in the study and agrees to undergo all follow up visit and planned procedures.  Exclusion Criteria:  Known active central nervous system metastases. Presence of renal insufficiency defined as eGFR(estimated glomerular filtration rate) < 30 ml/min/m2 Presence of liver disfunction, defined as level of AST(aspartate aminotransferase) and /or ALT(alanine aminotransferase) > 2,5 x ULN(upper limits of normal) (> 5 x ULN in patients with documented liver metastases); total bilirubin > 1,5 xULN ( bilirubin > 1,5 x ULN is acceptable if bilirubin is fractionated and direct bilirubin is < 35%) or albumin < 2,5 g/dL Abnormalities in blood count such as: hemoglobin < 9 g/dl, platelets < 100 x 109 /L, Absolute Neutrophil Count (ANC) <1,0 x 109 /L Ejection fraction in echocardiography < 50% History of active autoimmune diseases except for type I diabetes, hypothyroidism (treated only with hormone supplementation), psoriasis, albinism. Patient with diagnosed mental disorder preventing, in Investigator's opinion, from participating in a clinical trial. Pregnancy or breastfeeding. Female with childbearing potential or male participant with female partner of childbearing potential, who is unwilling or unable to use an acceptable method of contraception to avoid pregnancy throughout the entire clinical trial period and for 5 months after the end of treatment (last infusion) Prior therapy with an anti-PD-1/L1/L2 and/or anti-ICOS directed agent Patient is currently participating in another clinical trial. Active infection, which significantly affects the patient's clinical condition and requires treatment. Patient with prior bone marrow or solid organ transplantation. Patient requires immunosuppressive agents, including steroids (daily dose of prednisone or equivalent > 10 mg) Known immunodeficiency including HIV/AIDS(human immunodeficiency virus/acquired immunodeficiency syndrome) infection. Patient received any live vaccine within 28 days before enrollment. Heart Failure - NYHA(New York Heart Association functional classification system) III or IV Coexistence of active malignant tumor or history of malignant tumor after radical treatment with disease-free period > 2 years, except: cervical cancer in situ/ basocellular skin cancer/prostate cancer, after radical treatment. Other comorbidities symptoms or conditions that in Investigator's judgement prevent patient from participation in clinical trial.