Inclusion Criteria:  Patients with symptomatic PAD who signed the informed consent form (ICF) with:  Ankle-brachial index (ABI) < 0. 85 in at least one member, and ACD < 500 meters age > 18 years No history of lower-limbs arterial bypass surgery or angioplasties in the last year walking ability limited by the symptom of claudication and ability to complete a treadmill test  Exclusion Criteria:  high risk of bleeding  - Evidence of a recent history of bleeding in the last three months, hemorrhagic diathesis in the last three months, changes in coagulation tests (INR> 1.5 or aPTT > 2), pulmonary bronchiectasis, active cancer, active gastroduodenal ulcer, use of dual antiplatelet therapy.  Recent hemorrhagic stroke (1 month) or any history of previous hemorrhagic or lacunar stroke, if detected by occasional prior tomography, which is not part of the study protocol. severe heart failure (NYHA class III and VI) advanced stable kidney disease (estimated creatinine clearance <15 ml per minute), defined as eTFG <15 mL/min by 1.73 m2 calculated by the abbreviated formula Diet Modification in Kidney Disease (MDRD). the use of dual antiplatelet therapy, anticoagulation, or other antithrombotic therapy Continuous use of pentoxifylline or cilostazol Cardiac conditions that may lead to heart failure, such as unstable angina, arrhythmias, acute myocardial infarction in the last three months Non-cardiac conditions that may interfere with the ability to complete functional tests (e.g., chronic obstructive pulmonary disease, anemia, rheumatologic diseases) Non-cardiovascular conditions are considered by the researcher as associated with a poor prognosis.  a. Active cancer with a life expectancy of fewer than six months b. Collagen limiting diseases c. Previous or scheduled surgeries that prevent functional evaluation d. Orthopedic diseases that hinder functional evaluation (j) Pregnancy. Women with the potential to bear children should be under contraceptive strategies and take a negative pregnancy test to be enrolled.  (k) Patients with COVID in the contagious phase (PCR+)  -