Inclusion Criteria:  Exhibiting viral upper respiratory infection symptoms during the symptomatic phase of infection and tested positive for a common seasonal coronavirus (NL63, 229E, OC43, and HKU1) at time of diagnosis for initial symptoms Available for specimen collection greater than 14 days and less than 100 days after first exhibiting symptoms of confirmed seasonal coronavirus infection. Male and female participants of any race and ethnicity between 18 to 89 years of age (inclusive) at the time of enrollment in the study Able to communicate with the investigator, understand, and comply with the requirements of the study  Exclusion criteria:  Did not develop symptoms related to their diagnosed seasonal coronavirus infection Prior diagnosis of COVID-19 or any positive test result for SARS-CoV-2 infection or antibodies test Cohabitated with or has had significant exposure (per the Center for Disease Control guidelines) to another individual with known COVID-19 Protected populations including pregnant women, prisoners, mentally disabled persons, and wards-of-the state. Any significant condition, laboratory abnormality, or psychiatric illness that would prevent the participant from safely participating in the study Donated more than 500cc or 1 pint of blood in the past 60 days prior to the study blood draw Received a COVID-19 vaccine, including a single dose of a multiple dose vaccine regimen Participated in a COVID-19/SARS-CoV-2 study or received a SARS-CoV-2 antibody, or other SARS-CoV-2 therapeutic investigational drug or compound that will impact results of the study at the discretion of the investigator, such as but not limited to a SARS-CoV-2 antibody, therapeutic, or other medication that may impact the person's immune response