Inclusion Criteria:  Head and neck cancer patients undergoing cancer surgery and microvascular reconstruction. Age 18 years or older Ability to comprehend and willingness to participate in open-label conditioning study regardless of study group assignment  Exclusion Criteria:  Chronic opioid use prior to HNC diagnosis Substance use disorder Contraindication to receiving scheduled Acetaminophen, Ibuprofen, or Opioids Psychosis, delirium or other significant cognitive impairment preventing participation in study