Inclusion Criteria:  Age: older than 18 years WHO (ECOG) performance status 0-2 Histological proven HNC (squamous cell carcinoma) HPV negative tumors or high risk HPV positive tumors Stage III - IVB HNC of the hypopharynx, oropharynx and oral cavity according to UICC and AJCC guidelines Tumor extension and localization suitable for radiochemotherapy with curative intent Simultaneous standard chemotherapy with cisplatin applicable (no contra-indications) Dental examination and -treatment before start of therapy For women with childbearing potential and men in reproductive ages adequate contraception. Ability of subject to understand character and individual consequences of the clinical trial Written informed consent (must be available before enrolment in the trial)  Exclusion Criteria:  Refusal of the patients to take part in the trial Presence of distant metastases (UICC stage IVC) HPV positive tumors UICC Stage III with T1/2 N3, despite of smoking status Previous radiotherapy in the head and neck region Second malignancy that is likely to require treatment during the trial intervention or follow-up period or that, in the opinion of the physician, has a considerable risk of recurrence or metastases within the follow-up period Serious disease or medical condition with life expectancy of less than one year Participation in competing interventional trial on cancer treatment Patients who are not suitable for radiochemotherapy Pregnant or lactating women Patients not able to understand the character and individual consequences of the trial Nasopharyngeal and glottis laryngeal carcinomas Patients with contraindications for magnet-resonance tomography