Inclusion Criteria:  Patients ≥ 18 years old Chronic infected patients defined by:  Patients with persistent HPV-HR cytological infection (high risk) (as early as 6 months post-treatment of a cervical or vaginal injury), or a recurrence of a high-grade squamous intraepithelial lesion (CIN2 or CIN3 or HSIL) or a recurrence of cancer in the cervix or vagina  Patients who have given their written consent to participate in the study. Person affiliated or beneficiary of a social security scheme.  Exclusion Criteria:  Patient with an infection or a persistent lesion after treatment or not, linked only to low-risk HPV.