Inclusion Criteria:  Oropharynx or Oral Cavity Squamous Cell Carcinoma Patients: collected under the OPX Biomarker Protocol (IRB: 19-006036).  Normal Controls:  Age ≥ 18 years; Able to provide informed written consent documenting permission to give saliva sample for research testing.; Ability to complete questionnaire(s) by themselves or with assistance.  Exclusion Criteria:  Oropharynx or Oral Cavity Squamous Cell Carcinoma Patients: collected under the OPX Biomarker Protocol (IRB: 19-006036).  Normal Controls:  Any personal history of head or neck cancer including head or neck skin cancer. Other active malignancy ≤ 5 years prior to registration. EXCEPTIONS: Non-melanotic skin cancer, non-metastatic prostate cancer. NOTE: If there is a history of prior malignancy, they must not be receiving other specific treatment for their cancer. Dry mouth (xerostomia) caused by any chronic (>30 days) condition (known or unknown) or medication. Recent (within 30 days) or active upper aerodigestive tract or anogenital infections.