Inclusion Criteria:  Active rheumatoid arthritis Age 18-75 years eGFR > 30 mL/min absolute neutrophil count (ANC) ≥ 2 x 109 /L Platelet count > 150 x 103 /μL (corresponding to >150 x 109 /L) ALAT in the normal range or within 1.5x the upper limit of normal. Use of effective contraception (only woman of childbearing potential) Negative test for hepatitis and tuberculosis  Exclusion Criteria:  Known sensitivity to any of the medications used. Active severe infections Malignancy Diverticulitis Intake of medications which can influence the safety of the patient or the results of the study. Can include prescription medications, over-the-counter medications, herbal medicines or dietary supplements. Will be assessed by the investigators. Participation in other clinical intervention trials. Pregnancy or breastfeeding