Inclusion Criteria:  Patient beneficiary or affiliated to Social security system Consent signed  Exclusion Criteria:  Personal or family history (parents, brothers, sisters) of hemorrhage Personal or family history (parents, brothers, sisters) of thrombosis before 45 years old Taking an anti-inflammatory or an aspirin one week before the sampling Current take of an anticoagulant or antiaggregant treatment Surgery within previous month before the sampling Chronic pathology responsible of an inflammatory syndrome Episode of viral or bacterial infections Known HIV or Hepatitis C Virus (HCV) infection Participation in a therapeutic clinical trial