Inclusion Criteria:  Diabetic patients Patients with osteoarthritis awaiting knee replacement surgery Patients awaiting knee replacement surgery Patients who agree to sign informed consent  Exclusion Criteria:  Patients less than 55 years of age. Patients over 85 years of age. Patients who are unable to understand and want. Patients with severe neurological disorders or with severe disabilities. Rheumatoid arthritis patients Cancer patients Patients suffering from chronic inflammatory bowel syndromes (RCU and Crohn's disease) Patients on immunosuppressive therapy