Inclusion Criteria:  Neck mass present for >2 weeks with no signs/symptoms of infection Neck mass present for >2 weeks with signs/symptoms of infection that did not resolve with antibiotic therapy Palatine or lingual tonsillar asymmetry on physical exam Palatine or lingual tonsillar asymmetry on imaging, including asymmetric FDG uptake in palatine or lingual tonsils on PET-CT scans Unexplained throat pain for >2 weeks that did not resolve with antibiotic therapy  Exclusion Criteria:  Known diagnosis of HPV-OPC