Inclusion Criteria:  Provision of signed and dated informed consent form Stated willingness to comply with all study procedures and availability for the duration of the study Male or female, aged ≥ 18 and < 71 years (Note: HIV-negative subjects with MDS must be aged <50 at the time of signing the informed consent form) Diagnosed with Acute leukemias or T-lymphoblastic lymphoma (T-LBL) in 1st or subsequent CR Acute lymphocytic leukemia (ALL) or T-LBL as defined by the following: < 5% blasts in the bone marrow Normal maturation of all cellular components in the bone marrow No currently active extramedullary disease (EMD) (e.g., central nervous system (CNS), soft tissue disease) ANC ≥ 1,000/mm3 Acute myeloid leukemia (AML) defined by the following: < 5% blasts in the bone marrow No blasts with Auer rods Normal maturation of all cellular components in the bone marrow No currently active EMD (e.g., CNS, soft tissue disease) ANC ≥ 1,000/mm3 Acute biphenotypic leukemia (ABL)/Acute undifferentiated leukemia (AUL) defined by the following: < 5% blasts in the bone marrow Normal maturation of all cellular components in the bone marrow No currently active EMD (e.g., CNS, soft tissue disease) ANC ≥ 1,000/mm3 Myleodysplastic Syndromes (MDS), fulfilling the following criteria: Subjects with de novo MDS who have or have previously had Intermediate-2 or High-risk disease as determined by the IPSS. Current Intermediate-2 or High- risk disease is not a requirement Subjects must have < 20% bone marrow blasts, assessed within 60 days of informed consent Subjects may have received prior therapy for the treatment of MDS prior to enrollment Performance status: Karnofsky ≥ 60% Adequate organ function defined as: Cardiac: LVEF at rest ≥ 35% (RIC cohort) or LVEF at rest ≥ 40% (FIC cohort), or LVFS ≥ 25% Pulmonary: DLCO, FEV1, FVC ≥ 50% predicted by pulmonary function tests (PFTs). DLCO value may be corrected or uncorrected for hemoglobin Hepatic: total bilirubin ≤ 2.5 mg/dL, and ALT, AST, and ALP < 5 x ULN (unless ALT, AST, and/or ALP are disease related) Renal: SCr within normal range for age (see table 5.1B). If SCr is outside normal range for age, CrCl > 40 mL/min/1.73m2 must be obtained (measured by 24-hour (hr) urine specimen or nuclear glomerular filtration rate (GFR), or calculated GFR (by Cockcroft-Gault formula) Subjects must have the ability to give informed consent according to applicable regulatory and local institutional requirements Availability of deceased HLA MMUD cryopreserved product through Ossium cryobank HLA MMUD defined as 4-7/8 HLA-allele matching at MHC class (A, B, or C) or MHC class II (DRB1) Additional MHC class II HLA (DP and DQ) typing will be collected, but not incorporated in donor selection  Exclusion Criteria:  Pediatric patients (17 years or younger) Suitable HLA-matched related or 8/8 allele matched (HLA-A, -B, -C, -DRB1) unrelated donor excluding Ossium product Autologous HCT < 3 months prior to the time of signing the informed consent form Pregnancy or lactation Treatment with an investigational drug or other interventional GVHD clinical trials Current uncontrolled bacterial, viral or fungal infection (currently taking medication with evidence of progression of clinical symptoms or radiologic findings) Prior allogeneic HCT Primary myelofibrosis or myelofibrosis secondary to essential thrombocythemia or polycythemia vera Subjects with MDS may not receive RIC and must be < 50 years of age at the time of signing the informed consent form Any condition(s) or diagnosis, both physical or psychological, or physical exam finding that in the investigator's opinion precludes participation