Inclusion Criteria:  1:Patients scheduled for heart surgery 2:Moderate to severe depressive symptom measured by the qualified psychiatric doctors 3:Over 18 years of age 4:American Society of Anesthesiologists physical status I-III  Exclusion Criteria:  1:History of epilepsy 2:Major depression disorder patients undergoing antidepressive therapy within 2 weeks 3: Psychiatric illness 4: Drug abuse 5:History of allergy to esketamine 6:Hyperthyroidism 7:Patients can not cooperate with investigators on psychiatric assessments 8:Pregnant or breastfeeding woman 9:refuse to sign informed consent.