Inclusion Criteria:  Female patients aged 35-60 years old Patients with Glogau II-III skin classification Patients are willing to participate in the study and sign an informed consent form  Exclusion Criteria:  Patients with hypertrophic scars or keloid on the face Patients with open wound or infection on the face History of other topical treatment on the face within 1 month of enrollment Pregnant or breastfeeding mother Patients and/or their families are not willing to participate in the study.