Inclusion Criteria:  A COVID-19 diagnosis confirmed with a SARS-coV-2 viral infection positive polymerase chain reaction (PCR) test Age 18-80 years  Severity of disease according to the following criteria (at least one clinical parameter and one laboratory parameter are required):  a. Clinical and Imaging-based evaluation i. Respiratory rate > 23/min and < 30/min ii. SpO2 at room air ≤94% and ≥90% iii. Bilateral pulmonary infiltrates >50% within 24-48 hours or a severe deterioration compared to imaging at admission b. Evidence of an exacerbated inflammatory process i. LDH score> 450 U/L ii. CRP >50 mg/L iii. Ferritin >1650 ng/ml iv. Lymphocytes >800 cells/mm3 v. D-dimers >1 mcg/ml  Willing and able to sign an informed consent  Exclusion Criteria:  Age<18 years or >80 years Any concomitant illness that, based on the judgment of the Investigator is terminal Ventilated patient Pregnancy (positive urine pregnancy test [women of childbearing potential only]) or breastfeeding Patients with Immunodeficiency (eg, CLL, HIV, rituximab therapy) Unwilling or unable to provide informed consent Participation in any other Interventional study in the last 30 days