Inclusion Criteria:  Patients with locally advanced colorectal cancer met the following criteria at the time of enrollment:  Adult male and female, aged between 18-75 years Colonoscopic biopsy confirmed colonic adenocarcinoma Before treatment, the tumor was located between ileocecal part and ascending colon liver area There were no local complications (no complete obstruction, no massive active bleeding, no perforation and abscess formation) before operation The functions of heart, lung, liver and kidney meet the requirements of operation and anesthesia Informed consent form be signed  Exclusion Criteria:  Patients who met the following criteria at the time of inclusion were excluded from this trial:  Previous history of malignant colorectal tumor Patients with intestinal obstruction, intestinal perforation and intestinal bleeding requiring emergency surgery The primary tumor invades the abdominal wall and / or adjacent organs, resulting in inability to R0 resection Unresectable lymph node metastasis Recent diagnosis complicated with other malignant tumors Patients who had participated or were participating in other clinical trials within 4 weeks before enrollment American Society of Anesthesiologists (ASA) physical status classes ≥ grade IV and / or Eastern Cooperative Oncology Group (ECOG) physical state score ≥ 2 points (see Appendix for details) Patients with severe liver and kidney function, cardiopulmonary function, coagulation dysfunction or combined with serious basic diseases can not tolerate the operation Have a history of serious mental illness Pregnant or lactating women Patients with uncontrolled infection before operation Some researchers believe that patients with other clinical and laboratory conditions should not participate in the trial