Inclusion Criteria:  SARS-CoV-2 infection is confirmed on antigen test or PCR test Pulmonary infiltrative shadow is confirmed on chest X-ray test PaO2/FiO2 <=200mmHg at the time of screening  Exclusion Criteria:  Continue treatment for Pneumonia before SARS-CoV-2 infection SOFA score >= 15 Infection type on DIC diagnosis criteria >= 4 Deep Venous Thrombosis