Inclusion Criteria:  with the ability to understand this study and voluntarily sign the informed consent form. 18 to 65 years of age. with normal or abnormal without clinically significance on medical history, vital signs, physical examination, 12-lead ECG, laboratory examination, chest X-ray, and abdominal color ultrasound, etc. able to communicate with the researchers and follow the requirements specified in the protocol. agree to use effective contraceptive methods from signing the ICF to 6 months after the administration.  Exclusion Criteria:  plan to conduct any major surgery during the study. known allergy to monoclonal antibody drugs or other related drugs, or to the excipients of CM338 injection. with any clinical history including serious diseases or circulatory system, endocrine system, nervous system, blood system, immune system, mental system and metabolic abnormalities.