Inclusion Criteria:  Diagnosis with major depressive disorder or reference to "clinical depression" in patient charts. Recently prescribed monotherapy antidepressant medication (defined as new start, medication switch, or dose change in the past 3 months. Patients with inadequate response or tolerability concerns determined based on A PHQ-2 score of 3 or greater, recorded in medical records in the past 6 weeks or during screening, Able and willing to provide informed consent Able to use the Pathway Platform based on clinician's judgment, e.g. owns an iPhone version 5 or later or smartphones with Android operating systems, have an active data plan or regular WiFi access  Exclusion Criteria:  Missing PHQ-2 score in the past 6 weeks and/or unable to perform PHQ-2 at index visit Diagnosis with bipolar depression, schizophrenia, and/or schizoaffective disorder Patient no longer under primary care for depression and has transitioned to a psychiatric care team (i.e., Psychiatrist, Advance Practice Psychiatric Nurse, Psychiatric Nurse Practitioner, Psychiatric Physician Assistant). Lack of functional English literacy (indicated by primary language in electronic medical record).