Inclusion Criteria:  Patients of Clinic of Dermatology, Sexually Transmitted Diseases and Immunodermatology, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz Provision of an informed consent form prior to any study procedures Diagnosis of non-segmental acrofacial vitiligo with upper and lower limbs involvement Active vitiligo, defined as appearance of new areas of depigmentation or progression of existing areas of depigmentation within 3 months preceding screening Male or non-pregnant and non-breastfeeding female patients aged 18 to 80 years Women must use effective contraception one month preceding treatment, during treatment and 6 months after completing treatment. Confirmed valid health insurance  Exclusion Criteria:  Diagnosis of segmental, mixed, unclassified or undefined vitiligo Pregnancy and breastfeeding Hypersensitivity to methotrexate or any of the excipients Systemic immunosuppressive/immunomodulating i.e. cyclosporine A, corticosteroids within 4 weeks preceding eligibility screening or azathioprine, methotrexate, mycophenolate mofetil, Janus kinase - JAK within 8 weeks preceding eligibility screening Phototherapy due to vitiligo or any other medical conditions within the 4-week period preceding eligibility screening Any topical or systemic additional vitiligo treatment (e.g. antioxidants, ginkgo biloba, dermo-cosmetics) within 4 weeks preceding screening Surgical treatment of vitiligous lesions within past 4 weeks Severe liver dysfunction [bilirubin> 5 mg / dL (85.5 μmol / L)], including cirrhosis and hepatitis Severe renal impairment (eGFR <20 ml / min), Disorders of the hematopoietic system, bone marrow disorders (leukopenia, thrombocytopenia, anemia), Immunodeficiencies, including HIV infection Severe acute or chronic infections such as tuberculosis Alcohol abuse Mouth ulcers and known active gastric or duodenal ulcer disease Recent surgical wounds. Skin malignancies (currently or history of skin malignancy within 5 years preceding screening) Presence of skin characteristics that may interfere with study assessments Patients currently participating in any other clinical study Uncooperative patients