Inclusion Criteria:  A.Cytology or histology confirmed pancreatic adenocarcinoma with evidence of distant metastasis. B.No history of prior chemotherapy for pancreatic cancer, except adjuvant chemotherapy that completed at least 6 months before documentation of recurrence by imaging study. C.Patients with prior radiotherapy are eligible if there are other measurable target lesions that is not irradiated. D.At least one measurable lesion according to RECIST version 1.1 E.Ability to understand and willingness to sign a written informed consent document. F.ECOG performance status 0-1 G.Age of 20 years or above H.Adequate organ function as defined by the following criteria:  absolute neutrophil count (ANC) ≥ 1,500/mm3 hemoglobin level ≥ 9 g/dL platelet count ≥ 100,000/mm3 total bilirubin < 2 mg/dL aspartate aminotransferase (AST) / alanine aminotransferase (ALT) ≤ 3 x ULN or ≤ 5.0×ULN in the presence of liver metastases creatinine clearance rate (CCr) ≥ 60 mL/min (24-hour urine collection or calculated by Cockroft-Gault formula; male: [(140 - age) × weight (kg)]/[72 × serum creatinine(mg/dL)];female=male x 0.85  -I.Patients with childbearing potential shall have effective contraception for both the patient and his or her partner during the study.  Exclusion Criteria:  A. Other malignancy within the past 5 years except for adequately treated localized skin cancer or carcinoma in situ; B.Active or uncontrolled infection; C.Significant medical conditions that is contraindicated to study medication or render patient at high risk from treatment complications at physician discretion D.Pregnant women or nursing mothers, or positive pregnancy test for women of childbearing potential. E.History of active autoimmune disease within 3 years or use of steroid more than prednisolone 10mg/day.