Inclusion Criteria:  18-89 years old Diagnosed with diabetes Mellitus; hemoglobin A1C < 12% Diabetic foot ulcer present for minimum 30 days (Wagner grade 1 or 2 classification) Wound drainage is minimal or moderate No clinically active wound infection Able and willing to provide consent Has not participated in another research trial within 3 months of enrollment.  Exclusion Criteria:  Unable to keep weekly research appointments Unable or unwilling to use offloading device if recommended Wounds with large amount (high) drainage Active gangrene Wounds impending surgical intervention (including revascularization or plastic surgery) Untreated osteomyelitis Soft tissue infection (can be enrolled once infection is cleared) Active Charcot arthropathy BMI >40kg/m2 History of AIDS History of organ transplant or impending transplant End stage renal disease requiring dialysis Decompensated hepatic or cardiac disease Select autoimmune diseases Lymphedema Oral steroid use in last 3 months Venous stasis disease Active malignancy (cancer) Unable to sign consent Active alcohol or substance abuse Pregnant or lactating women Insufficient vascular flow to heal a wound Hemoglobin A1C >12%