Inclusion Criteria:  Hepatitis B Virus Infection  TherVacB sub-cohort:  confirmed chronic hepatitis B virus infection: HBsAg positive for at least 1 year prior inclusion HBeAg status documented for at least 6 months  Exclusion Criteria:  TherVacB sub-cohort:  age >70 years co-infection with HIV, HCV (RNA positive), clinically relevant concomitant liver diseases (ALD, NASH, Haemochromatosis, Autoimmune hepatitis, AT1, Wilson's disease, primary biliary cirrhosis etc.) significant comorbidities (e.g. malignancies) immunosuppressive treatment (> 40 mg Cortisol- equivalent) liver cirrhosis (judged clinically or based on ultrasound/transient elastography) History of hepatocellular carcinoma