Inclusion Criteria:  Age: > 18 years of age Acute ischemic stroke with large extra- and intracranial artery occlusion and intraarterial mechanical thrombectomy treatment. Successful recanalization after thrombectomy with TICI 2b or 3. Informed consent by the patient  Exclusion Criteria:  Informed consent not possible within 7 days after thrombectomy due to impaired awareness or speech disturbances. Permanent stent during thrombectomy. Severe complications, such as severe intracranial hemorrhage, during or after thrombectomy including prolonged ICU stay. Modified rankin scale (mRS) over 3 before admission. Diagnosis of dementia with mini mental state examination (MMSE) < 26 points in the medical history Intracranial hypertension in the medical history or brain imaging. Patent foramen ovale in the medical history. Glaucoma in medical history. Inability to complete study visits