Inclusion Criteria:  Diagnosis of CP and scheduled for TP-IAT; ≥18 years old; Diabetes-free before surgery as defined by the standards of the American Diabetes Association*. No previous major pancreatic surgeries. Patients who have had minor surgeries including transduodenal sphincteroplasty or Whipple/Beger procedure are eligible.  Exclusion Criteria:  Patients who are under immunosuppression; Pregnant and breastfeeding women. Patients who have liver damage based on ALT, AST, and total bilirubin levels (>3 times normal levels); Patients who have had prior pancreatic surgeries including distal pancreatectomy or lateral pancreaticojejunostomy. We have observed that islet yield and function are negatively correlated with these types of pancreatic surgeries.