Inclusion Criteria:  Their age should range from 35 to 50 years. Their body mass index (BMI) should range from 18 to 35 Kg/m2. The presence of one or more symptomatic type 2, 3, 4, 5, or 6 uterine fibroids according to the FIGO classification. The dominant fibroid diameter should range from 4 to 8 cm as assessed by ultrasound. They should not be seeking future fertility. They should be refusing any surgical intervention whether myomectomy or hysterectomy.  Exclusion Criteria:  Post-menopausal status or premature ovarian failure. Type 0, 1 and 7 uterine fibroids according to FIGO classification. Previous myomectomy or any uterine surgery. Previous or ongoing hormonal treatment.