Inclusion Criteria:  ASA Physical Status Classification Grade 1-3 Patients with an ECOG score of 0 or 1 when selecting a subject for the study Patients who can provide written consent to participate in clinical trials Patients requiring the use of vasopressor because the mean arterial pressure is not maintained more than 65 mmHg during surgery  Exclusion Criteria:  Patients with peripheral arterial diseases Patients with allergic history to study drugs If surgery on other areas is scheduled at the same time or is an emergency operation Patients with history of previous abdominal surgery involving the flap donor site Pregnant If there are other major medical or psychiatric disorders that may affect treatment response Left ventricular ejection fraction < 30% or with a history of arrhythmia that is not controlled by medication Refuse to participate