Inclusion Criteria:  Adults between the ages of 20 and 65 who are willing to sign the consent form of the subject. For those with BMI ≥ 24, men's body fat ≥ 25%, women's body fat ≥ 30% Those who are not pregnant and are willing to cooperate with contraception during the trial period. Those who have no history of cardiovascular disease, organ transplantation, epilepsy or convulsions, liver and kidney disease, malignant tumors, endocrine disease, mental disease, alcohol or drug abuse, and other major organic diseases (according to medical history).  Exclusion Criteria:  Pregnant women, people with a history of cardiovascular disease, organ transplantation, epilepsy or convulsions, liver and kidney disease, malignant tumors, endocrine diseases, mental illness, alcohol or drug abuse, and other major organic diseases (according to medical history). Those who had undergone major surgery or bariatric surgery (according to medical history). Currently or within 3 months before participating in the screening, those subjects used drugs that can affect body fat or increase weight significantly, such as systemic corticosteroids, tricyclic antidepressants, atypical psychiatric drugs, and mood stability Drugs (according to medical history).