Inclusion Criteria:  Women with established causes of infertility and indications for the use of ART methods, according to the Order of the Ministry of Health of the Russian Federation "On the use of assisted reproductive technologies, contraindications and limitations to their use" No. 107 n dated August 30, 2012. Infertility due to female and/or male factor. Presence of ovaries accessible for aspiration of follicles. Anatomical and functional capability of uterus to bear pregnancy.  Exclusion Criteria:  Women with established contraindications to the use of ART methods, according to the Order of the Ministry of Health of the Russian Federation "On the use of assisted reproductive technologies, contraindications and limitations to their use" No. 107 n dated August 30, 2012. Presence of pregnancy Hypersensitivity to follitropin alfa or excipients. Ovarian cysts (not associated with polycystic ovarian syndrome), uterine hemorrhage of unclear etiology Premature ovarian failure Presence of clinically significant systemic disease Presence of chronic cardiovascular, hepatic, renal or pulmonary disease Neoplasia Narcomania, alcoholism