Inclusion Criteria:  Age ≥18 years.  Indication for complex PCI, defined as:  PCI of a chronic total occlusion Two-stent PCI of a bifurcation lesion. PCI of severely calcified lesion Preprocedural biomarker Troponin-I within normal range Left ventricular ejection fraction >50% Written informed consent obtained  Exclusion Criteria:  Previous randomization in the study Decompensated heart failure requiring inotropic /adrenergic support, invasive or non-invasive ventilation or intra-aortic balloon pump/ventricular assist device therapy less than 48 hours prior to randomization Recent PCI (<3 months) Known previous myocardial infarction in the target vessel or regional wall motion abnormalities within the myocardium subtended by the target vessel(s) Any contraindication for Cardiac magnetic resonance imaging Pregnancy