Inclusion Criteria:  - residents of Viana, Espírito Santo, aged between 18 and 49 years  Exclusion Criteria:  Pregnant women; History of severe allergic reaction (anaphylaxis) to any previously administered vaccine; Having received another vaccine in the last 14 days; Belonging to a priority risk group for vaccination, as per the PNI recommendations; Have fever or flu-like symptoms; Have previously received any vaccine for covid-19 at any time; Recent diagnosis of covid-19 with onset of symptoms 28 days before vaccination; Disorders of coagulation and use of anticoagulants.