Inclusion Criteria:  Patients diagnosed with CKD as defined in the KDIGO Clinical Practice Guidelines for the Evaluation and Management of Chronic Kidney Disease 2012 Edition; Non-CKD patients with hypertension, diabetes, hyperlipidemia, hyperuricemia, eGFR (CKD-EPI formula) of 60-89 ml/min/1.73m^2 and other risk factors for CKD; Healthy population. Signed the informed consent voluntarily.  Exclusion Criteria:  。Patients identified to be unsuitable for enrollment by the study physician.