Inclusion Criteria:  Patients who are fully informed and sign informed consent by themselves or their guardians; Patients receiving allogeneic hematopoietic stem cell transplantation; Patients with acute graft-versus-host disease of grade II-IV were diagnosed after transplantation; Patients with stable implantation of granulocytes and platelets. ECOG score ≤3  Exclusion Criteria:  Patients with severe brain, heart, kidney or liver dysfunction unrelated to graft-versus host disease; Patients with uncontrollable active infection; Patients with recurrence of primary malignant hematopathy; Expected survival is less than 3 months Patients who have histories of severe allergic reactions Pregnant or lactating women The researcher judges that there are other factors that are not suitable for participating