Inclusion Criteria:  18 years and older at admission. Confirmed diagnosis of severe SARS CoV 2 infection. category 6 and 7 of World's Health Organization (WHO) COVID 19 ordinal scale on Clinical Improvement .  Exclusion Criteria:  under 18 years of age no Confirmed diagnosis of SARS CoV 2 infection. category 1dnd 5 of World's Health Organization (WHO) COVID 19 ordinal scale on Clinical Improvement .