Inclusion Criteria:  Sputum Ziehl-Neelsen stain positive for AFB (≥1+) Culture or Xpert positive for Mtb; those who are smear+ but ultimately Xpert or culture negative, will be included until their culture results return at which time they will retrospectively be removed from the study. No history of TB treatment (i.e., no history of partial or complete treatment for a previous TB episode) Has at least 1 household contact with whom they have shared a house with during the previous one month Agrees to have household contact notified about study  Exclusion Criteria:  Household contact ineligible for TB LION study Pregnant at enrollment Previously diagnosed with diabetes or hemoglobin A1c>6.5% on testing No Xpert or culture confirmation and unable to provide sputum sample Known multidrug-resistant tuberculosis (MDR) or extensively drug resistant (XDR) TB case at recruitment or found at time of enrollment BMI <14 kg/m2 Lower extremity edema/kwashiorkor Reported neuropathy in lower extremities (may result from thiamine deficiency)