Inclusion Criteria:  Patients ≥40 and of age Patients who meets the American College Rheumatology (ACR) criteria and has lasted for at least three months after diagnosis of one-sided or bilateral knee osteoarthritis. Radiographic evidence of grade 1 ~ 3 osteoarthritis based on the Kellgren & Lawrence radiographic entry criteria at visit 1 Score of 100mm pain VAS ≤ 80mm at visit 1 Written consent form voluntarily Score of 100mm pain VAS ≥ 40mm at visit 3 Patients with an individual medication compliance of 70% or more of the IP administered during the Run-in period  Exclusion Criteria:  Patients who has a history of hypersensitivity to components of IP, NSAIDs including COX-2 inhibitors, a history of hypersensitivity to aspirin, or allergic reactions to sulfonamides Patients with inflammatory, infectious, metabolic, septic arthritis or rheumatoid arthritis other than osteoarthritis Patients with a condition that can affect the joints Patients who have undergone arthroscopic surgery within 1 year , knee joint surgery within 5 years, synoviorthesis within 3 months prior to visit 1 to the target knee, or who have planned surgery during the trial period  Patients who have used corticosteroids as follows:  Inj. of corticosteroid, including intraarticular administration, into the target knee within 3 months prior to visit 1 Oral corticosteroid administration within 1 month prior to visit 1 Patients who have intraarticular injected hyaluronic acid or cell therapy products, gene therapy products, etc. for the treatment of osteoarthritis within 3 months prior to visit 1