Inclusion Criteria:  Healthy males aged 30 to 65 years inclusive Body mass index (BMI) of 18.0 to 35.0 kg/m2 Must be willing and able to communicate and participate in the whole study Must have regular bowel movements Must provide written informed consent Must agree to adhere to contraception requirements  Exclusion Criteria:  Subjects who have received any IMP in a clinical research study within the 90 days prior to Day 1 Subjects who are, or are immediate family members of, a study site or sponsor employee Evidence of current SARS-CoV-2 infection from results of diagnostic tests or from symptoms reported at screening or admission History of any drug or alcohol abuse in the past 2 years Regular alcohol consumption A confirmed positive alcohol breath test at screening or admission Current smokers and those who have smoked within the last 12 months. Current users of e-cigarettes and nicotine replacement products and those who have used these products within the last 12 months Subjects with pregnant or lactating partners Radiation exposure, including that from the present study, excluding background radiation but including diagnostic x-rays and other medical exposures, exceeding 5 mSv in the last 12 months or 10 mSv in the last 5 years. Subjects who do not have suitable veins for multiple venepunctures/cannulation Clinically significant abnormal clinical chemistry, haematology or urinalysis. Subjects with Gilbert's Syndrome are allowed. Confirmed positive drugs of abuse test result Positive hepatitis B surface antigen (HBsAg), hepatitis C virus antibody (HCV Ab) or human immunodeficiency virus (HIV) antibody results Evidence of renal impairment at screening, as indicated by an estimated creatinine clearance (CLcr) of <80 mL/min using the Cockcroft-Gault equation History of clinically significant cardiovascular, renal, hepatic, dermatological, chronic respiratory or gastrointestinal disease, neurological or psychiatric disorder Serious adverse reaction or serious hypersensitivity to any drug or the formulation excipients Presence or history of clinically significant allergy requiring treatment. Hay fever is allowed unless it is active Donation of blood or plasma within the previous 3 months or loss of greater than 400 mL of blood Subjects who are taking, or have taken, any prescribed or over-the-counter drug or herbal remedies (other than up to 4 g of paracetamol per day) in the 14 days before IMP administration. Failure to satisfy the investigator of fitness to participate for any other reason