Inclusion Criteria:  Pathologically or cytologically confirmed advanced solid tumor that failed, couldn't tolerate or refused standard treatments; ECOG score 0 or 1; At least 1 measurable lesion according to RECIST 1.1  Exclusion Criteria:  Known hypersensitivity to any ingredient of TWP-101; Receiving any anti-cancer drugs within 4 weeks; History of serious systemic diseases; History of serious autoimmune diseases; Pregnancy or lactating women.