Inclusion Criteria:  Male or female aged 18-90 Signed and dated informed consent and IRB form by the patient or legally authorized health care proxy. Diagnosis of acute ischemic stroke due to large vessel occlusion based on clinical and radiographic evidence as determined and documented by the Stroke Neurology team at Northshore University Hospital. Participants must meet criteria for intra-arterial thrombectomy as determined and documented by the Stroke Neurology and Interventional Neuroradiology attending physicians at Northshore University Hospital. Angiography must reveal a thromboembolism which is completely occluding flow within the intracranial portion of the internal carotid artery, the M1 or proximal M2 portions of the middle cerebral artery.  Exclusion Criteria:  Patients that do not otherwise meet criteria for endovascular intervention Large vessel occlusion of the anterior cerebral artery, posterior circulation, or distal M2 portion of the middle cerebral artery. Recanalization of only TICI 0-2A. Pregnant or lactating women. Therapeutic anticoagulation prior to presentation. Known allergic reactions to contrast dye or components of minocycline (tetracycline) or magnesium sulfate. Patients with a known prior diagnosis of heart block or prior myocardial infarction (increased risk of adverse reaction to MgSO4). Renal insufficiency (creatinine > 2.5 mg/dL) Severe hepatic functional impairment (AST > 10xULN, bilirubin > 5xULN) Systemic lupus erythematosus Idiopathic intracranial hypertension