Inclusion Criteria:  Healthy subject. Age: between 30 and 65 years. Subject with right and left NLF rating grade 3 or 4 (Moderate or Severe) on the Wrinkle Severity Rating Scale (WSRS), as assessed by a Blinded Live Evaluator. Subject having the same WSRS grade on both NLFs (i.e., symmetrical NLFs). Subject with marionette's lines that do not require to be treated in addition to nasolabial folds, according to the Blinded Live Evaluator. Subjects willing to abstain from any other facial plastic surgical or cosmetic procedures (i.e., dermal fillers, toxin treatments, facial ablative or fractional laser, microdermal abrasion, chemical peels, non-invasive skin-tightening) below the level of the lower orbital rim, for the duration of the study. Subjects agreeing not to take Anti-histamines within 2 weeks prior to touch-up visit Subject able to comply with protocol requirements and to complete all required visits. Subject, psychologically able to understand the study related information and to give a written informed consent. Subject having given freely and expressly his/her informed consent to participate in the study, and use of data privacy, prior to any study-related procedure being performed. Subject agreeing to have photographs taken. Female of childbearing potential must have a negative urinary pregnancy test (UPT) at Visit 1 and practice a reliable method of contraception throughout the study, and for at least 12 weeks prior to study enrolment. Subject affiliated to a health social security.  Exclusion Criteria:  Subject presenting any symptom which can be related to a medical condition that is likely to make the subject not being compliant with the study schedule, at the discretion of the investigator Pregnant or breastfeeding woman or planning a pregnancy during the study. Had prior surgery in the mid- and/or lower-face area, including the nasolabial fold(s), or has a permanent implant or graft in the mid- and/or lower-face area, or a tattoo, a scar, moles, or anything that could interfere with effectiveness assessments. (NOTE: Rhinoplasty is permitted if the procedure was ≥ 12 months prior to study enrolment). Subject in a social or sanitary establishment. Subject who had been deprived of their freedom by administrative or legal decision or who is under guardianship. Subject participating to another research on human beings or who is in an exclusion period of one. Subject having received 4500 euros indemnities for participation in researches involving human beings in France in the 12 previous months, including participation in the present study. Subject suffering from a severe or progressive disease or any other pathology that may interfere with the evaluation of the study results. Subject with known history of or suffering from autoimmune disease and/or immune deficiency. Subject with a past history of streptococcal disease, such as acute rheumatic fever or recurrent sore throats with cardiac localisation. Subjects suffering from porphyria. Subject suffering from inflammatory and/or infectious cutaneous disorders in or near the studied zones (herpes, acne, mycosis, papilloma…). Subject with recurrent herpes is not eligible even if asymptomatic at time of inclusion. Subject having history of severe allergy or anaphylactic shock including hypersensitivity to hyaluronic acid, to gram positive bacterial proteins, to lidocaine or antiseptic solution or amide type local anaesthetics. Subject predisposed to develop keloids or hypertrophic scarring. Subject prone to develop inflammatory skin conditions or having tendency to bleeding disorders. Subject having received treatment with a laser, a dermabrasion, a surgery, a peeling or other ablative procedure below the inferior orbital rim within the past 6 months prior to study start. Subject having received injection with a resorbable filling product (eg, hyaluronic acid, collagen) below the inferior orbital rim within the past 12 months prior to study start. Subject having received at any time injection with a slowly resorbable filling product (polylactic acid, calcium hydroxyapatite, combinations of hyaluronic acid (HA) and hypromellose, HA and dextran microbeads or HA and TriCalcium Phosphate (TCP), etc.) or with a non-resorbable filling product (polyacrylamide, silicone, combination of methacrylic polymers and collagen, polymer particles, etc.). Subject having received at any time a treatment with tensor threads below the inferior orbital rim. Subject who received oral surgery (tooth extraction, orthodontia or implantation) within 6 weeks prior to study start or who plans to undergo any of these procedures during the study. Subject having started or changed her oral contraceptive or any other hormonal treatment during 12 weeks prior to study start or planning to change it during the study. Subject using medication such as aspirin, nonsteroidal anti-inflammatory drugs (NSAID) (ibuprofen, naproxen, etc.), antiplatelet agents, anticoagulants, vitamin C or other substances known to increase coagulation time within one week prior to treatment dates. Subject using medication that reduce or inhibit hepatic metabolism (cimetidine, beta-blockers, etc.).  Subject undergoing a topical treatment on the test area or a systemic treatment:  Anti-histamines during the 2 weeks prior to study start; Immunosuppressors and/or corticoids during the 4 weeks prior to study start; Retinoids during the 6 months prior to study start.