Inclusion Criteria:  medical history of sesame allergy, IgE-mediated sesame allergy confirmed as positive skin prick tests with sesame allergens (diameter of the wheal greater than 3mm) and/or specific IgE level greater than 0.35 kilo units of Allergen per liter (kUA/l) (UniCAP method), reaction to sesame protein during OOFC (maximum dose 4000g), signed Informed Consent by parent/legal guardian and patient aged >16 years old, patient's/caregivers' cooperation with researcher.  Exclusion Criteria:  no confirmed sesame allergy, negative oral food challenge with sesame protein (maximum dose 4000g), severe asthma, uncontrolled mild/moderate asthma: forced expiratory volume at one second (FEV1)<80% (under 5. percentile), FEV1/forced vital capacity (FVC)<75% (under 5. percentile), hospitalization due to asthma exacerbation within last 12 months, current oral/sublingual/subcutaneous immunotherapy with other allergen, eosinophilic gastroenteritis, a history of severe recurrent anaphylaxis episodes, chronic diseases requiring continuous treatment, including heart disease, epilepsy, metabolic diseases, diabetes,  medication:  oral, daily steroid therapy longer than 1 month within last 12 months, at least two courses of oral steroid therapy (at least 7 days) within last 12 months, oral steroid therapy longer than 7 days within last 3 months, biological treatment, the need to constantly take antihistamines, therapy with β-blockers, angiotensin converting enzyme (ACE) inhibitors, calcium channel inhibitors, pregnancy, no consent to participate in the study, lack of patient cooperation.