Inclusion Criteria:  Age 18-85 years old; Symptomatic, non-valvular persistent atrial fibrillation (atrial fibrillation duration ≥ 1 week), and is ineffective to one or more anti-arrhythmic drugs; CHA2DS2-VASc score ≥ 2 points; The patient is ready to undergo atrial fibrillation catheter ablation and left atrial appendage closure surgery; Provide an informed consent form that is willing to participate in the research, follow-up trials and evaluation procedures.  Exclusion Criteria:  Past left atrial appendage occlusion, atrial fibrillation catheter ablation or surgical ablation history; There are plans for cardiac surgery within 90 days; Stroke/transient ischemic attack occurred within 30 days; Have had atrial septal defect repair or have an ASD/PFO occluder in the body; Heart failure NYHA heart function grade IV; LVEF<30%; Combined with other serious diseases, the life expectancy is less than 2 years; Within 6 months after cardiac revascularization or other cardiac surgery; Women who are pregnant, breastfeeding, planning to become pregnant, or women of childbearing age who have not adopted reliable contraceptive methods; Obviously abnormal liver and kidney function and coagulation function;