Inclusion Criteria:  Patients must be able to understand English and provide written informed consent; Males and females between 18 and 70 years of age; Recipients of a primary or secondary kidney transplant 4 weeks to 10 years prior to screening; Patients receiving a stable dose (i.e., no dose adjustments) of TAC-IR for a minimum of 4-7 days at screening; Patients with a screening TAC-IR trough level of 3-9 ng/mL, measured between Day -7 to 0; Women of childbearing potential must have a negative urine pregnancy test at screening; Patients must be willing to commit to and comply with the schedule of study visits. The patient is not scheduled to begin any new medication that could interfere with tacrolimus blood levels, including prescription and over-the-counter medications, herbal or food supplements (including grapefruit and pomegranate products), or medications listed in Appendix 1.  Exclusion Criteria:  Recipients of any transplanted organ other than kidney; Patients with an estimated glomerular filtration rate (eGFR) (MDRD4) < 25 mL/min at screening; Patients with significant visual impairments affecting their ability to complete the study requirements and assessments: patient's vision is 20/200 or worse; Patients with significant hearing impairments affecting their ability to complete the study requirements and assessments, based on Investigator discretion; Patients with any severe medical condition (including infection) requiring acute or chronic treatment that in the Investigator's opinion would interfere with study participation;  Patients who have a history of any of the following, based on documentation of clinical conditions and concomitant medications in the medical records:  Cognitive decline secondary to stroke, per Investigator discretion Dementia Resected or existing brain tumor Acute or chronic bipolar psychosis or schizophrenia per Investigator discretion Mental retardation Moderate or severe traumatic brain injury Failure of any major organ other than the kidneys (e.g., end-stage liver disease) Known non-adherence (defined as documentation in the patient chart of multiple missed visits and/or medication doses) which in the Investigator's opinion would interfere with the objectives of the study Patients with medical history of hypertension or diabetes which is unmanageable by medically approved intervention (e.g., medication/diet) as assessed by the Investigator; Patients with acute or chronic depression, corresponding to a score of ≥20 (corresponding to moderate depression) on the BDI-II at screening; Patients who are taking any acute or chronic medications that may impact reaction time, memory, or sleep habits, based on Investigator discretion; Patients on concurrent immunosuppression with MMF (CellCept) or MPS delayed release tablets (Myfortic), or generic versions of these medications, as per SOC, who have not been on stable doses (i.e., no dose adjustments or formulation change) for at least 4-7 days prior to screening; Patients receiving prednisone or equivalent >10 mg/day; Patients with an episode of biopsy-proven or suspected acute rejection that requires treatment within 3 months of screening; Patients who are being actively treated for cancer (with the exception of non-invasive basal cell or cutaneous squamous cell carcinoma); Patients known to be human immunodeficiency virus (HIV) positive; Patients with any form of current drug or alcohol abuse as assessed by the Investigator; Patients who were treated with any other investigational agent within 1 month prior to screening;  Pregnant or nursing women or women planning to become pregnant, where pregnancy is defined as a state of the female patient after conception and until the termination of gestation, confirmed by a positive urine laboratory test; women of child-bearing potential, defined as all women physiologically capable of becoming pregnant who are unwilling to use a defined SOC birth control method; UNLESS they are:  Women whose career, lifestyle, or sexual orientation preclude intercourse with a partner Women whose partners have been sterilized by medically approved means