Inclusion Criteria:  age of 18-60 years old The diagnosis of CSCR based on clinical and imagining evaluation informed consent  Exclusion Criteria:  Chronic CSCR Laser treatment (6 months prior to enrollment) IVB treatment (3 months prior to enrollment) Other retinal diseases History of eye diseases Diabetes Mellitus Renal or hepatic diseases Allergy to saffron or crocin Pregnancy or lactation Beta-blocker, diuretic, or corticosteroid (1 week prior to enrollment) Bleeding tendency or any coagulation disorder