Inclusion Criteria:  Patients with primary trigeminal neuralgia receive trigeminal nerve microvascular decompression, and healthy people without a history of chronic pain or patients with facial nerve palsy without chronic pain receive facial nerve decompression as a control; Age from 30 to 60 years old Complete white blood cell count: 4.8~11.0x109/L  Exclusion Criteria:  Patients with co-infection and tumor Patients with craniocerebral disease