Inclusion Criteria:  Patients with locally advanced or metastatic renal cell carcinoma. Patients scheduled to undergo anti-angiogenic treatment or immunotherapy Eastern Cooperative Oncology Group (ECOG) Status 0, 1 and 2. Women of child-bearing potential must agree to undergo a urine pregnancy screening per standard Radiology departmental protocol, in place to prevent imaging of pregnant patients. A female of child-bearing potential is any woman (regardless of sexual orientation, having undergone a tubal ligation, or remaining celibate by choice) who meets the following criteria: 1) Has not undergone a hysterectomy or bilateral oophorectomy; or 2) Has not been naturally postmenopausal for at least 12 consecutive months (i.e., has had menses at any time in the preceding 12 consecutive months). Ability to understand and the willingness to sign a written informed consent.  Exclusion Criteria:  Subjects may not be receiving any other anti-angiogenic agents, at the time of enrollment. Subjects must not be pregnant since pregnancy is a contraindication to administration of gadolinium-based contrast agents. Any contraindication to MRI per Radiology Department's routine protocol, e.g. MRI-incompatible objects, including but not limited to medical devices (e.g. pacemakers, automated implantable cardioverter defibrillators, etc.) and other foreign bodies. Known severe allergic reaction to Gadolinium-based contrast agents. Patients with sickle cell disease and patients with other hemolytic anemias (low red blood count in body). Patients with uncontrollable claustrophobia, severe lower back pain, and uncontrollable tremors, to the point that it would render them unable to tolerate an MRI study.