Inclusion Criteria:  Must be age between 35 and 70 years old; Clinical diagnosis of metabolic syndrome; BMI score more than 27 or less than 24 Clinical diagnosis of 3 grade degneration meniscus leisons;  Exclusion Criteria:  Must be able to have no acute knee injury such as car crash or acute sports injury; Must be able to have no knee surgeries history; Must be able to have no rheumatoid arthritis or serious knee osteoarthritis with deformity; Must be able to have no contraindications to MRI; Must be able to have no severe cardiopulmonary disease; Must be able to have no musculoskeletal or neuromuscular impairments ; Must be able to have good visual, hearing, or cognitive;