Inclusion Criteria:  Participants who understand and sign the informed consent form voluntarily. Age ≥ 18 years old and ≤ 80 years old, regardless of sex. hospitalized patients diagnosed with acute coronary syndrome within 1 month. Coronary angiography (CAG) showed that in addition to the culprit lesion, there was at least one lesion with 30-70% stenosis. the lesion shown by OCT was lipid-rich plaque (Lipid pool arc > 90 °).  Exclusion Criteria:  Allergic to colchicine. Colchicine was taken within 10 days before randomization. Abnormal liver function (ALT > 3 times the upper limit of normal value). Abnormal renal function (creatinine clearance rate < 45 ml/min). Thrombocytopenia (PLT < 100G/L). Uncontrolled infectious diseases during the screening period. During the screening period, patients with immune diseases or immune-related diseases such as systemic lupus erythematosus, asthma, inflammatory bowel disease, gout, malignant tumor and so on. Long-term use of non-steroidal anti-inflammatory drugs, hormones, immunomodulatory and chemotherapeutic drugs outside the regimen during the study period. History of surgery or interventional therapy within 6 months prior to the screening period. A history of coronary artery bypass grafting or a plan for coronary artery bypass grafting within 1 year. More than 50% stenosis of the left main artery or severe calcification / distortion of the coronary artery are considered to affect the assessment of OCT. Diagnosed with mental disorders such as anxiety or depression. Pregnant women, lactating women or women of childbearing age who do not use effective contraceptive methods. Participated in other clinical trials within 3 months before the screening period. Do not receive standardized treatment after being diagnosed with coronary heart disease. The life expectancy of the subjects is less than 1 year. The researchers determined that other conditions in which the patient was not suitable to participate in the clinical trial.