Inclusion Criteria:  About 100 women aged> 40 years will be included in the study with diagnosed pharmacologically controlled hypertension, including:  Group I-about 50 women > 40 years before the onset of menopause Group II - approximately 50 women > 1 year after the onset of menopause  Exclusion Criteria:  unstable hypertension;  diagnosed heart failure or typical symptoms of heart failure; documented: hyperandrogenism, hyperendogenism, insulin resistance, premature ovarian failure, polycystic ovary syndrome; previous myocardial infarction; diagnosed cardiomyopathy (hypertrophic, dilated, restrictive, puerperal, tachyarrhythmic); storage diseases; stroke, TIA, an intracerebral bleeding; severe hyperthyroidism or hypothyroidism; pregnancy or lactation; chronic kidney disease in stage IV, V according to NKF and patients undergoing dialysis; documented cancer process; patient's inability to cooperate and / or give informed consent not to participate in a research; alcohol and drug abuse; active autoimmune disease; taking immunosuppressive, cytostatic drugs, glucocorticoids or antiretroviral drugs; bone marrow transplant or other organ transplantation, treatment with blood products during the last 6 months; active systemic infection; HBV, HCV or HIV infection or a positive result for the presence of HbS antigen or anti-HCV antibodies; surgery or serious injury in the last month; vaccination interview in the last 3 months; patients who have not expressed their informed consent to participate in the study