Inclusion Criteria:  Patients must have a positive screen for prostate cancer as confirmed by a prostate specific antigen (PSA) >= 2 ng/ml Patients must elect to elect to undergo PHI blood test and TRUS-guided elect to undergo PHI blood test and TRUS-guided biopsy as part of routine clinical care Patients must be age >= 18 years Patients must agree to use adequate contraception (e.g. Barrier method of birth control; abstinence) for 24 hours following completion of imaging Patients must have the ability to understand and the willingness to sign a written informed consent prior to registration on study  Exclusion Criteria:  Patients who have had a prior biopsy for prostate cancer Patients who have contraindications to MRI (i.e. pacemakers, aneurysm clips or shaped fragments) are not eligible Patients receiving any other treatments or investigational agents are not eligible Patients with a glomerular filtration rate (GFR) < 30mL/min are ineligible to receive intravenous contrast per standard magnetic resonance (MR) exclusion criteria Patients administered a radioisotope < 5 physical half-lives prior to the date of study PET/MRI Patients administered IV X-ray contrast medium < 120 hours prior to the date of study PET/MRI Patients who report taking multivitamins on the day of study PET/MRI