Inclusion Criteria:  Patient is age between 18 and 85 years old, inclusive; Patient qualifies for a primary TKA based on the investigator's clinical judgement; Patient is a candidate for commercially available Persona® Knee Joint Prosthese which is compatible with the ROSA® Knee System; Patient is willing and able to provide written Informed Consent.  Exclusion Criteria:  Patient planning to receive bilateral TKA surgery within 3 months; Patient who has undergone revision surgery for partial or total knee arthroplasty of the ipsilateral knee； Bone tumor patient who has undergone bilateral TKA; Stable, painless ipsilateral knee arthrodesis within a satisfactory function and position; Patient who has received partial or total knee arthroplasty for the contralateral knee within 6 months prior to scheduled primary TKA; Patient has active, local infection or previous intra-articular infection in the affected joint; Insufficient bone stock on femoral or tibial surfaces; Skeletal immaturity; Osteomalacia or any metabolic disorder which may impair bone formation; Patient has neurologic disorders (e.g. Stroke); Patient hs diseases that could lead to prosthesis instability, failure of prosthesis fixation or postoperative complications (e.g. Arthrodesis, Scoliosis, Lumbar Stenosis) Patient has a hip pathology with significant bone loss (e.g. avascular necrosis of the femoral head with collapse, severe dysplasia of the femoral head or the acetabulum); Patient has hip pathology severely limiting range of motion (e.g. arthrodesis, severe contractures, chronic severe dislocation); Patients with severe knee instability caused by incomplete collateral ligaments, cruciate ligaments, and posterolateral structural injury; Rheumatoid arthritis accompanied by an ulcer of the skin or history of recurrent breakdown of the skin; Patient has severe angular knee deformity of >20° varus or >20° valgus; Patient has a known or suspected sensitivity or allergy to one or more of the implant materials; Patient has other contraindications specified by the implant manufacturer; Patient is pregnant or considered a member of a protected population (e.g. prisoner, mentally incompetent); In the past 1 month participated in or is participating in clinical trials related to other drugs and medical devices; Any other conditions that the investigator considers inappropriate for participation in this trial.