Inclusion Criteria:  1. Capable of giving signed informed consent as described in Appendix 1, which includes compliance with the requirements and restrictions listed in the Informed Consent Form (ICF) and in this protocol.  2. Male subjects who are 18 to 55 years old, inclusive, at the time of signing the ICF.  3. Have a body weight of 50.0 to 90.0 kg (inclusive) and body mass index (BMI) of 18.0 to 32.0 kg/m2 (inclusive) at Screening and Day -1.  Exclusion Criteria:  1. Any evidence of clinically relevant pathology, especially prior diagnosis of bone disease, or any uncontrolled condition that will affect bone metabolism (such as, but not limited to osteoporosis, osteogenesis imperfecta, hyperparathyroidism, hyperthyroidism, hypothyroidism, osteomalacia, rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, current flare-up of osteoarthritis and/or gout, active malignancy, renal disease [defined as glomerular filtration rate <45 mL/min], Paget's disease of the bone, recent bone fracture [within 6 months], and malabsorption syndrome).  2. Have ONJ or risk factors for ONJ such as invasive dental procedures (eg, tooth extraction, dental implants, oral surgery) within 6 months prior to Day 1, poor oral hygiene, periodontal, and/or pre-existing dental disease.  3. Have bone fractures within 6 months prior to Day -1. 4. Have a history of immunodeficiency. 5. Abnormal serum calcium: current hypocalcemia or hypercalcemia at Screening or Day -1. Serum calcium levels must be within reference ranges. NOTE: Subjects who meet this exclusion at Screening will be allowed to receive supplementation and undergo 1 repeat evaluation, at the discretion of the Investigator.  6. Known vitamin D deficiency (25[OH]D levels <10 ng/mL [25 nmol/L]) at Screening or Day -1. NOTE: Subjects who meet this exclusion at Screening will be allowed to receive supplementation and undergo 1 repeat evaluation, at the discretion of the Investigator.  7. Known intolerance to calcium or vitamin D supplements.