Inclusion Criteria:  Age: more than or equal to 18 years Primary rhegmatogenous retinal detachment with proliferative vitreoretinopathy more than or equal to grade C  Exclusion Criteria:  Patients with a history of open globe injury Recurrent retinal detachment or primary failed retinal detachment surgery History of vitreoretinal procedure Retinal vascular diseases (Diabetic retinopathy, retinal vein occlusion,...etc) Pregnant or breastfeeding females Inability to attend regular follow-up visits History of pulmonary or extra-pulmonary tuberculosis.