Inclusion Criteria:  Male or non-pregnant female ages 18-80 years old Having evidence of myocardial ischemia, or participants with stable or unstable angina pectoris, old myocardial infarction, or Stabled recent myocardial infarction (occurred more than 7 days before enrollment, including non-ST-segment elevation and ST-segment elevation myocardial infarction) Participants are are eligible to undergo any type of coronary revascularization surgery, such as balloon angioplasty, stenting, and coronary artery bypass grafting (CABG); Participants Can understand the trial's purpose, voluntarily participate and acknowledge all the risks and benefits, providing written informed consent and are willing to accept invasive radiographic during the follow-up period. Angiography confirmed as De novo bifurcation lesion, the stenosis rate of side branch (diameter) ≥70％ Suitable for PCI and the side branch lesions is not expected to stent implantation, and no DCB treatment for the main branch. If a stent is implanted into the main-branch, it's usually necessary to perform a final balloon kissing on the two branches Residual stenosis of the side-branch lesion ≦30% after successful pre-treatment, with a TIMI flow grade 3 side branch referenced diameter was 2.0~4.0mm, lesion length was ≤40 mm  Exclusion Criteria:  Any AMI occurred within 1 week before operation Unstable arrhythmias, such as high-risk ventricular premature beats, ventricular tachycardia severe heart failure (above NYHA IV) or Left ventricular ejection fraction (LVEF) <30% (ultrasound or left ventricular angiography) Renal function insufficiency: Serum creatinine >2.0mg/dl; Or undergoing hemodialysis; definite hemorrhagic tendency, antiplatelet and anticoagulant therapy contraindication and unable to anticoagulant therapy; Have a history of peptic ulcer or gastrointestinal hemorrhage in the past 6 months; Have a history of cerebrovascular accidents (stroke) such as cerebral hemorrhage, cerebral infarction in the past 6 months; allergic to contrast agent, paclitaxel, and rapamycin and its derivatives Has been diagnosed as advanced cancer and other serious diseases, lifespan are expected less than 1 year Patients who are considered to have poor compliance and cannot complete the trial in accordance with requirements; Or other reasons that considered by the investigator, it be unsuitable to enroll the participant; Be participating in any other clinical trials, or have participated in clinical trials of other drugs or medical devices before being selected but have not reached the timeline of the primary endpoint; Female who are pregnant or breastfeeding (women who may become pregnant must undergo a pregnancy test within 7 days before the baseline surgery)；Or have fertility plan/can not have adequate contraception during the study period Thrombus in the target lesion The target lesion is completely occluded The target lesion side branch are severely calcified and fail to pre-dilated or need kissing balloon dilatation The target lesion is intracoronary stent restenosis Have grade C or above dissection after target lesion pre dilation/ double-balloon kiss dilation, or restenosis >30% Non-target lesions cannot be processed prior to target lesions, or processing failed