Inclusion Criteria:  Healthy male volunteers Subjects aged 18 - 45 years Subjects weighing ≥ 50.0 kg and ≤ 100.0 kg Subjects with a body mass index (BMI) ≥ 19.0 and ≤ 26.0 kg/m2  Exclusion Criteria:  Subjects with evidence or history of clinically significant disease Subjects with a history of previous cancer Subjects with a history of hypertension, or abnormal blood pressure at screening/baseline measurements (systolic blood pressure > 140 mmHg and/or diastolic blood pressure > 90 mmHg confirmed by a repeat measurement on the same day) Subjects with a history of blood donation 3 months before study drug infusion Subjects with a history of exposure to antibodies 12 months before study drug infusion Subjects with previous exposure to anti-VEGF therapy