Inclusion Criteria:  Subjects free of malignancy  men or women 40-70 yrs aged  Patients with colon cancer  men or women 18-85 yrs aged Biopsy-proven colon cancer with indication to chemiotherapy Chemiotherapy (first line or second line) not started  Exclusion Criteria:  All subjects  Ischemic cardiac history known heart disease blood hemoglobin concentration <8g / dl Acute or chronic systemic illnesses, (apart from diabetes, essential or secondary hypertension for patients) Pregnancy or breastfeeding or in progress  Subjects free of malignancy  Cardiovascular risk factor (active smoking or greater than 10 pack-years, diabetes, hypertension or known dyslipidemia not controlled by the diet) Glomerular filtration rate estimated by the CKD epi (Chronic Kidney Disease - Epidemiology Collaboration) formula < 60 ml.min-1.1.73 m-² Contraindication to exercise Drug taking in progress (except estrogen-progestogen contraception)