Inclusion Criteria:  Age: 55-70 years BMI: 28-40 kg/m2  Exclusion Criteria:  Any drug that, in the investigator's opinion, may affect the study HbA1c > 48 mmol/mol Known heart failure, previous blood clots, or other heart disease that, in the investigator's opinion, may affect the study, including abnormal ECG and/or echocardiography with evidence of structural heart disease Liver disease (ALAT > 3 x of upper normal range), renal failure (eGFR < 60 ml/min), anaemia (Hb < 6.5), current or previous malignant disease which, in the investigator's opinion, may affect the study Current alcohol abuse (> 21 items per week) Blood donation within the last 3 months before the study day Participation in studies/examinations involving radioactive isotopes within the last 6 months Claustrophobia