Inclusion Criteria:  Men 35-74 years old No known diagnosis of prostate cancer Life expectancy >10 years Meet either cohort 1 or 2 criteria Cohort 1: Documented pathogenic or likely pathogenic germline genetic mutation in a prostate cancer risk gene from a CLIA-certified laboratory (ATM, ATR, BRCA1, BRCA2, BRIP1, CHEK2, EPCAM, FANCA, GEN1, HOXB13, MLH1, MSH2, MSH6, NBN, PALB2, PMS2, RAD51C, RAD51D, TP53) Cohort 2: A strong family history suggestive of high genetic risk for prostate cancer with negative clinical genetic testing  Exclusion Criteria:  Prior diagnosis or treatment of prostate cancer Inability to undergo prostate MRI Inability to receive MRI contrast agent