Inclusion Criteria:  All ocular criteria apply to study eye unless otherwise noted.  Age ≥ 21 years. Phakic or Pseudophakic with a posterior chamber intraocular lens Symptomatic corneal edema associated with endothelial dysfunction which may be secondary to Fuchs corneal dystrophy or pseudophakic bullous keratopathy.  Exclusion Criteria:  All ocular criteria apply to study eye unless otherwise noted.  Other corneal disease Anterior chamber intraocular lens, Sutured or scleral-fixated intraocular lens. Macular disease that in the investigator and/or sponsor's opinion would limit the ability of the subject to demonstrate improvement in BCVA. History of refractive surgery. Descemet membrane detachment. History of uveitis or other ocular inflammatory disease. History of glaucoma or ocular hypertension, incisional glaucoma surgery in either eye or prior glaucoma laser procedures in either eye Prior incisional eye surgery within 3 months prior to study treatment or penetrating or endothelial keratoplasty. History of ocular neoplasm. ETDRS BCVA in the fellow eye is worse than 35 letters (Snellen equivalent of 20/200). Female who is pregnant, nursing, or planning to become pregnant, or who is of childbearing potential and not using a reliable means of contraception during the study. Subject is currently participating in or has participated within the last 3 months in any other clinical trial of an investigational drug by ocular or systemic administration. Any concomitant medical or psychological condition that could interfere with study participation or is otherwise not suitable for entry into the study in the opinion of the investigator.