Inclusion Criteria:  Patients > 17 years old with no upper age limit. Histological diagnosis of DLBCL Stages I or II Patients who have signed informed consent.  Exclusion Criteria:  Patients with elevated LDH (lactate dehydrogenase) ECOG (Eastern Cooperative Oncology Group) > 2 Stage III or IV Bulky mass (> 7.5 cm) Extranodal involvement (patients with testicular, central nervous system and primary mediastinal non-Hodgkin's lymphoma are excluded) HIV positive patients Platelet count <100,000 / mcl and total leukocyte count <3,000 / mcl Marked impairment of ventricular function (FEy <50%) Moderate / severe renal impairment defined by Cl. Cr. <50 ml / min Severe liver disease: prothrombin rate <50% and / or bile level. total> 2.5 times normal value Pregnant and breastfeeding Previous or concomitant diagnosis of indolent lymphoma Patients who have previously received chemotherapy and / or radiotherapy