Inclusion Criteria:  Newly diagnosed patients with stages III-IV ovarian or endometrial cancer Receiving first-line carboplatin and paclitaxel chemotherapy after surgery ≥18 years, children under the age of 18 will be excluded due to rarity of disease Physician's clearance to participate in moderate-vigorous intensity exercise Able to read, write, and understand English Ability to understand and the willingness to sign an informed consent document Willing to undergo two venous blood draws for the study  Exclusion Criteria:  Pre-existing musculoskeletal, neurological, or cardiorespiratory conditions, as determined by the treating oncologist Participants with uncontrolled intercurrent illness, as determined by the treating oncologist Participants with psychiatric illness/social situations that would limit compliance with study requirements, as determined by the treating oncologist Participants who have received prior chemotherapy for cancer treatment (e.g. taxanes for breast cancer)