Inclusion Criteria:  - Subject (aged 6 months to 18 years) is enzymatically/genetically confirmed to have GSD 1b and has been on regular GCSF treatment for >= 1 month  Exclusion Criteria:  Subject fails to provide relevant background medical information, or comply with all requirements of the clinical trial, or sign the informed consent Subject has any co-morbidity or condition that could increase the risk of empagliflozin treatment (e.g. renal failure with eGFR <30 mL/min/1.73m2 or requiring dialysis, diabetes requiring insulin &/or oral hypoglycemic agents, dyslipidemia requiring pharmacological intervention) Subject is pregnant, or a sexually active female who does not consent to use effective contraception during the study History of liver transplantation is NOT an exclusion criterium