Inclusion Criteria:  Age greater than or equal to 18 years and less than or equal to 75 years  Children are excluded from this study because the disease does not occur in children Individuals over the age of 75 are excluded from this study to improve the likelihood of a catheterizable prostatic artery, given the higher rates of occlusive atherosclerosis with advanced age Ability to provide informed consent Biopsy-proven unilateral or bilateral prostate adenocarcinoma, any stage (any N or any M) Maximal tumor diameter >= 2.0 cm on each affected side, documented on prostate magnetic resonance imaging (MRI) within 3 months of first scan Gleason score >= 4+4 Cancer of the Prostate Risk Assessment (CAPRA) score >= 6  Exclusion Criteria:  Body mass index (BMI) > 30 kg/m^2 Prior treatment for prostate cancer, or any use of anti-androgen therapy within 3 months of first scan History of any pelvic radiotherapy Greater than 10 pack-year smoking history or severe atherosclerosis from prior CT imaging study, if available Stage IV or V chronic kidney disease by estimated glomerular filtration rate (eGFR) within 45 days of first scan Platelet count < 50 x 109/L and/or international normalized ratio > 1.5 Severe allergy to iodinated contrast Active urinary tract infection or recent episode of prostatitis within 1 month of first scan Inability to tolerate prolonged supine positioning