Inclusion Criteria:  Male or female subjects with aged 18 and over Living in around Jakarta Type 2 diabetes mellitus patients with depression symptom Patients with Body mass index 20-30 m/kg2 Patients are able and willing to maintain diet, physical activity, and lifestyle for 3 months Patients are able and willing to control for follow up  Exclusion Criteria:  - Presence of severe hepatic dysfunction, defined as cirrhosis hepatic Presence of severe renal dysfunction, defined as chronic kidney disease stage 5 or e-GFR ≤15 or history of hemodialysis Patients with acute coronary syndrome Presence of acute systemic inflammatory response syndrome (SIRS). The term SIRS describes a clinical state arising from a non-specific cause, infective, or otherwise Recent obtained vitamin D therapy within the last 3 months Current or regular use of corticosteroids within immunosuppressant dosage Presence of major depression Presence of psychosis Current or regular use of anti-depressant Current or regular use of phenytoin or phenobarbital For females: current pregnancy and lactation period Patients who refuse the studies