INCLUSION CRITERIA:  Subjects of both genders will be considered for inclusion in this study. There will be no racial, ethnic, or gender discrimination.  Affected Subjects:  18 years of age or older Diagnosed with moderate-severe psoriasis clinically confirmed by licensed physician, or advanced practitioner consisting of typical skin findings and/or associated findings of systemic disease of joints, nails and hair and may be scheduled to initiate biologic treatment for psoriasis  Healthy Controls:  Females and males 18 years of age or older  EXCLUSION CRITERIA:  Affected Subjects:  Pregnant or lactating women Subjects with a contraindication to MRI scanning will not receive the CMR assessment.  These contraindications include subjects with the following devices:  i. Central nervous system aneurysm clips  ii. Implanted neural stimulator  iii. Implanted cardiac pacemaker or defibrillator  iv. Cochlear implant  v. Ocular foreign body (e.g. metal shavings)  vi. Implanted Insulin pump  vii. Metal shrapnel or bullet  viii. Estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73m^2 body surface area according to the Modification of Diet in Renal Disease criteria  History of seizures or taking anti-epileptic medications Inability to provide informed consent  Healthy Controls:  Diagnosis of an inflammatory disease (including psoriasis, psoriatic arthritis, rheumatoid arthritis, lupus, inflammatory bowel disease) Pregnant women and lactating women Subjects with a contraindication to MRI scanning will not receive the CMR assessment.  These contraindications include subjects with the following devices:  ix. Central nervous system aneurysm clips  x. Implanted neural stimulator  xi. Implanted cardiac pacemaker or defibrillator  xii. Cochlear implant  xiii. Ocular foreign body (e.g. metal shavings)  xiv. Implanted Insulin pump  xv. Metal shrapnel or bullet  xvi. Estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73m^2 body surface area according to the Modification of Diet in Renal Disease criteria  History of seizures or taking anti-epileptic medications Inability to provide informed consent