Inclusion Criteria:  Patients undergoing elective LC under general anesthesia, ASA status I-II, aged from 18 to 65 years old of both sex  Exclusion Criteria:  Contraindications to regional block (coagulopathy, infection at the needle insertion site, or diaphragmatic paralysis) Altered conscious level Pregnancy Body mass index (BMI > 35) Advanced hepatic or renal failure Chronic opioid consumption