Inclusion Criteria:  CRC patients who are candidates for surgical treatment with curative intent (risk I-III). American Society of Anesthesiologists' Physical Status Classification (ASA) <3. Patients aged between 18 and 85 years. Eastern Cooperative Oncology Group (ECOG) scale between 0-2. Patients with preserved cognitive function. Patient's authorization after reading the study information sheet.  Exclusion Criteria:  Candidates for neoadjuvant therapy. Patients with concomitant carcinoma. Allergy to the supplied nutraceutical or presence of malabsorption syndrome. Presence of mental disorders Patient with active infection or antibiotic therapy in the last month. Previous colorectal surgery