Inclusion Criteria:  Having received oxaliplatin-based chemotherapy for at least one cycle History of variceal bleeding (including hematemesis or melena) Portal hypertension confirmed by CT or MRI Esophageal and / or gastric varices confirmed by endoscopy Informed consent signed  Exclusion Criteria:  With serious life-threatening diseases of circulation / blood / respiratory system With known causes of liver cirrhosis (hepatitis B, hepatitis C, autoimmune, schistosomiasis, non-alcoholic fatty liver disease, and etc.) With contraindications of endoscopic treatments and TIPS; Participation refused