Inclusion Criteria:  Visual acuity +1.0 logMAR or better Willing to give informed consent Ability to washout from current intraocular pressure lowering medications -  Exclusion Criteria:  All secondary glaucomas Previous glaucoma intraocular or laser surgery (selective laser trabeculoplasty permitted when done 18 months or longer from Screening) Refractive surgery Ocular infection or inflammation