Inclusion Criteria:  Confirmed SARS-CoV-2 infection within 5 days prior to randomization Initial onset of COVID-19 signs/symptoms within 5 days prior to the day of randomization and at least 1 of the specified COVID-19 signs/symptoms present on the day of randomization Fertile participants must agree to use a highly effective method of contraception Has at least 1 characteristic or underlying medical condition associated with an increased risk of developing severe illness from COVID-19  Exclusion Criteria:  History of or need for hospitalization for the medical treatment of COVID-19 Prior to current disease episode, any confirmed SARS-CoV-2 infection Known medical history of active liver disease Receiving dialysis or have known moderate to severe renal impairment Known human immunodeficiency virus (HIV) infection with a viral load greater than 400 copies/mL or taking prohibited medications for HIV treatment Suspected or confirmed concurrent active systemic infection other than COVID-19 History of hypersensitivity or other contraindication to any of the components of the study intervention Current or expected use of any medications or substances that are highly dependent on CYP3A4 for clearance or are strong inducers of CYP3A4 Has received or is expected to receive convalescent COVID-19 plasma Has received or is expected to receive any dose of a SARS-CoV-2 vaccine before the Day 34 visit Participating in another interventional clinical study with an investigational compound or device, including those for COVID-19 through the long-term follow-up visit Known prior participation in this trial or other trial involving PF-07321332 Oxygen saturation of <92% on room air, or on their standard home oxygen supplementation for those who regularly receive chronic supplementary oxygen for an underlying lung condition Females who are pregnant or breastfeeding