Inclusion Criteria:  Pre-randomization mRS </= 3 Confirmed diagnosis of chronic subdural hematoma Completed informed consent  Exclusion Criteria:  Acute subdural hematoma Prior treatment of target subdural hematoma Markwalder assessment >/= 3 Glasgow Coma Scale < 9 Presumed microbial superinfection CT or MRI evidence of intracranial tumor or mass lesion Life expectancy < 1 year Women who are pregnant, lactating, or who are of childbearing age and plan on becoming pregnant during the study Current involvement in another clinical trial that may confound study endpoints