Inclusion Criteria:  Patients with newly histologically confirmed non-keratinizing nasopharyngeal carcinoma, including WHO II or III ,with no distant metastasis Age between 18-45, female Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0 or 1 Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤2.5×upper limit of normal (ULN),serum total bilirubin (TBIL) ≤2.0 times the upper limit of normal (ULN) . Adequate renal function: creatinine clearance rate≥60 ml/min or Creatinine ≤1.5× upper limit of normal value. No history of infertility. No history of hysterectomy or bilateral ovariectomy. Patient have signed on the informed consent, and well understood the objective and procedure of this study  Exclusion Criteria:  Histologically or cytologically confirmed with keratinizing squamous cell carcinoma of the nasopharynx. Women in the period of pregnancy, lactation, or reproductive without effective contraceptive measures. Known history of other malignancies (except cured basal cell carcinoma or carcinoma in situ of the cervix). Patients with severe dysfunction of heart, liver, lung, kidney or marrow. Patients with severe, uncontrolled disease or infections. Refuse or fail to sign the informed consent . Patients with personality or mental disorders, incapacity or limited capacity for civil conduct.