Inclusion Criteria:  Patient with an established diagnosis of Sezary syndrome (stage IVA1) The patient must have a minimum wash-out period of 3 weeks between the last dose of prior systemic therapy Patients should have recovered from all adverse events related to prior therapy to ≤ grade 1 Signed informed consent form prior to any protocol-specific procedures.  Exclusion Criteria:  Visceral metastasis of lymphoma Concomitant administration of radiotherapy or systemic anti-cancer therapy including but not restricted to: chemotherapy, biological agents, or immunotherapy Patients with known NCI CTCAE grade 3 or higher active systemic or cutaneous viral, bacterial, or fungal infection. Patients with any serious underlying medical condition that would impair their ability to receive or tolerate the planned treatment and/or comply with study protocol. Patients with dementia or altered mental status that would preclude understanding and rendering of informed consent document. Patients with known allergy to methoxsalen or heparin -