INCLUSION CRITERIA:  In order to be eligible to participate in this study, an individual must meet the following criteria:  Aged 3 years and older. Must be eligible to receive (based on official FDA authorization or approval) and scheduled to receive or have already received a COVID-19 vaccine outside of this facility.  Must meet the definition of affected participant or control participant:  Affected participants must have evidence of a primary or secondary immune deficiency or dysregulation under another NIAID protocol or as documented by an outside physician. Control participants are healthy volunteers that do not have evidence of a primary or secondary immune deficiency or dysregulation and may include unaffected relatives of affected participants. Ability to provide informed consent. Willing to have blood samples stored for future research. Able to proficiently speak, read, and write English.  EXCLUSION CRITERIA:  Individuals meeting any of the following criteria will be excluded from study participation:  Receipt of any other vaccine within 14 days prior to screening. Planned non-COVID-19 vaccination within 28 days after COVID-19 vaccination(s). Any condition that, in the opinion of the investigator, contraindicates participation in this study (e.g. specific autoinflammatory diseases, interferonopathies). Self-reported history of HIV.