Inclusion Criteria:  Patients of ACLF (APASL criteria) - jaundice (serum bilirubin ≥ 5 mg/dL and coagulopathy (INR ≥ 1.5) complicated within 4 weeks by clinical ascites and/or encephalopathy in a patient with previously diagnosed or undiagnosed chronic liver disease/cirrhosis, Age 18-70 yrs Baseline HVPG ≥ 12 mmHg.  Exclusion Criteria:  Contraindications to NSBB (heart rate < 65 /min, BP < 110/65 mm Hg, asthma, heart failure), Portal Vein Thrombosis, Hepatocellular carcinoma, HVOTO, HE grades 2-4, NSBB therapy within 5 days, Pregnancy, Lactation, Planned for LT in the next 12 weeks No consent.