Inclusion Criteria:  Women with breast cancer diagnosis confirmed by a physician and receiving paclitaxel for the first time. Above 20 years of age.  Exclusion Criteria:  Patients with neurological disease histories. Patients with histories of the hand-foot syndrome. Patients with distant cancer metastases or skin metastases. Patients with nail lesions or the absence of fingers. Patients with a low tolerance to cold, and edema.