Inclusion Criteria:  Aged 60 years or older.  Scheduled for one of the predefined surgical procedures:  off-pump coronary bypass surgery on-pump coronary bypass surgery aortic valve replacement laparoscopic hemicolectomies thoracoscopic lung resections femoral popliteal and tibial bypass surgery laparoscopic radical prostatectomies  Exclusion Criteria:  Lack of informed consent or inability to give informed consent. Severe postoperative nausea & vomiting (PONV), needing corticosteroids as PONV prophylaxis. Urgent, not elective surgery Hypersensitivity or known allergic reactions to methylprednisolone  Preoperative systemic use of steroids:  Including, but not limited to, the use of corticosteroids > 4 weeks before surgery of at least 4 mg methylprednisolone equivalents. Excluding inhalational and topical steroids Preexisting muscle disease o Including, but not limited to: Steinert's disease, amyotrophic lateral sclerosis (ALS), Duchenne dystrophy, amputation of dominant arm or hand.