Inclusion Criteria:  are above the age of 18. have traumatic, surgical, or chronic wounds. have radiotherapy related tissue injury. have thermal, chemical, and/or electrical burn injuries. have pressure ulcers, diabetic foot ulcers, venous ulcers, arterial ulcers, and/or neuropathic skin ulcers. have acute ischemic wounds  Exclusion Criteria:  have infected wounds. have wounds with exposed vital structures such as nerves, arteries, and/or veins. have wounds associated with malignancy.