Inclusion Criteria:  Office SBP at Screening as follows:  ≥155 mmHg and ≤180 mmHg for patients with untreated hypertension ≥145 mmHg and ≤180 mmHg for patients on antihypertensive medications 24-hour mean SBP >130 mmHg and ≤160 mmHg by ABPM after at least 4 weeks of run-in on protocol-specified background antihypertensive medication  Exclusion Criteria:  Secondary hypertension, orthostatic hypotension Elevated potassium >5 mEq/L Estimated glomerular filtration rate (eGFR) of ≤30 mL/min/1.73m^2 Received an investigational agent within the last 30 days Type 1 diabetes mellitus, poorly controlled Type 2 diabetes mellitus, newly diagnosed Type 2 diabetes mellitus History of any cardiovascular event within 6 months prior to randomization History of intolerance to SC injection(s)