Inclusion Criteria:  Female patients Type of surgery; Modified Radical Mastectomy (MRM) Physical status ASA I, II, III. Age ≥ 18 and ≤ 65 Years. Body mass index (BMI): > 20 kg/m2 and < 35 kg/m2.  Exclusion Criteria:  Age <18 years or >65 years BMI <20 kg/m2 and >35 kg/m2 Known sensitivity or contraindication to drug used in the study (local anaesthetics, opioids). History of psychological disorders and/or chronic pain. Contraindication to regional anaesthesia e.g. local sepsis, pre- existing peripheral neuropathies and coagulopathy. Patient refusal. Severe respiratory or cardiac disorders. Advanced liver or kidney disease. Pregnancy. Physical status ASA IV and Male patients.