Inclusion Criteria:  Patient eligible to receive the Harmony TPV, meeting the indications for use criteria per current geography-specific device labeling at time of study enrollment Patient (or patient's legally authorized representative) is willing to consent to participate in the study  Exclusion Criteria:  Anatomy unable to accommodate a 25 Fr delivery catheter system Obstruction of the central veins Clinical or biological signs of infection including active endocarditis Planned concomitant branch pulmonary artery stenting at time of implant Positive pregnancy test at baseline (prior to CT angiography and again prior to implant procedure) in female subjects of childbearing potential Patients with right ventricular outflow tract obstruction (RVOTO) lesions surgically treated with an RV-PA conduit implant A major or progressive non-cardiac disease (e.g. liver failure, renal failure, cancer) that results in a life expectancy of less than one year Planned implantation of the Harmony TPV in the left heart Known allergy to aspirin, heparin, or nickel Echocardiographic evidence of intracardiac mass, thrombus, or vegetation Pre-existing prosthetic heart valve or prosthetic ring in any position