Inclusion Criteria:  Patients with a confirmatory diagnosis of Acute Lymphoblastic Leukemia relapsed to bone marrow described with more than 5% blasts in bone marrow at any stage of treatment or positivity of minimal residual disease at any stage of treatment. Patients who have signed their informed consent from the institution for hospitalization, and accepted the performance of the bone marrow study, and the administration of chemotherapy.  Exclusion Criteria:  Patients with a diagnosis of phenotypic leukemia or bilinear leukemia Patients treated only with palliative regimen or transfusion support Patients without the administration of prophylaxis to the central nervous system by intrathecal chemotherapy Patients with lymphoblastic leukemia with a positive Philadelphia chromosome Patients with severe comorbidities may put treatment therapy at risk. Patient with a history of cardiac toxicity or arrhythmias associated with treatment