Inclusion Criteria:  Male subjects or female subjects of non-childbearing potential ≥18 and ≤55 years of age at the time of consent BMI >18.5 and <30 kg/m2 and a weight of ≥50 kg Sexually active males must use a double barrier method of contraception during the study and for at least 90 days after the last dose of study drug Male subjects must be willing not to donate sperm until 90 days following the last study drug administration  Exclusion Criteria:  Personal or family History of significant medical illness Clinically significant abnormalities on screening tests/exams History of or significant risk of committing suicide Donation of plasma within 7 days prior to dosing Donation or significant loss of blood within 30 days prior to the first dosing Major surgery within 3 months or minor surgery within 1 month prior to admission Use of prohibited prescription, over-the-counter medications or natural health products Alcohol-based products 24 hours prior to admission Female subjects who are currently pregnant or lactating Use of tobacco or nicotine products within 3 months prior to Screening Significant alcohol consumption History of drug abuse within the previous 2 years, or a positive drug screen History of allergy to study medications Not suitable for study in the opinion of the Principal Investigator