Inclusion Criteria:  Participants with age over 40 but under 80, who need to take colonoscopy or diagnostic confirmed colorectal cancer patient.  Exclusion Criteria:  Participants who are undergoing cancer treatments or have diagnosed with cancer, received cancer treatment in the past. Participants who have received any cancer treatments, including chemotherapy and radiotherapy before taking surgery. Participants have received any surgery for colorectal cancer in the past. Pregnant women or nursing women.