Inclusion Criteria:  Subject is age 18 or older, able and willing to provide consent and agrees to comply with the study procedures Subject must have chronic venous insufficiency of stages C3, C4, or C5 according to the Clinical-Etiological-Anatomical-Pathophysiological (CEAP) classification system Not compliant with their currently prescribed compression system  Exclusion Criteria:  Active malignancy other than non-melanoma skin cancer Study ulcer suspicious for cancer Subjects who are pregnant and/or breastfeeding In the opinion of the PI the subject cannot comply with study procedures