Inclusion Criteria:  PLHIV receiving ART (TDF/FTC/EFV, TDF/FTC+RPV, TDF+3TC+RPV, TDF/3TC/DTG, or ABC/3TC/EFV) for more than 6 months hs-CRP >=2 mg/mL Agree to participate the study  Exclusion Criteria:  Those who has contraindication for colchicine Those who had history of allergy to colchicine Those who was diagnosed with myocardial infarction or ischemic stroke Those who was diagnosed with cirrhosis child B or C Those who had eGFR <30 ml/min/1.73 m2) Those who had HIV viral load more than 40 copies/mL in 6 months before entering the study Those who has CD4 less than 300 cells/mm3 Deny to participate the study