Inclusion Criteria:  Participants > 18 years old Able to give written informed consent Able to understand and complete questionnaire forms independently  Exclusion Criteria:  Participants < 18 years old Participants with cancer and/or undergoing chemotherapy Participants with difficult to cannulate veins (DTCV) Participants with lymphoedema in either hand Participants with pre-existing Raynaud's disease Participants with Diabetes (Type 1 & 2) Participants with generalised anxiety disorder Participants with diagnosis of hypertension Participants with any cardiovascular disease, previous stroke, episodes of DVT, recent treatment for venous thromboembolism (VTE), recently administered heparin, participants on warfarin or any anticoagulant treatment (including NOACs). Participants not able to give written informed consent Participants not able to comprehend or complete questionnaire forms independently