Inclusion Criteria:  Patients suspected with UTUC and planned to undergo surgery such as such ureteroscopy or radical nephroureterectomy.  Participants without any tumor disease and willing to attend the study by providing morning urine.  Male or female patients aged >= 18 years. Participants signed informed consent form.  Exclusion Criteria:  Individuals unwilling to sign the consent form or unwilling to provide morning urine for test or unwilling to provide the medical record.  Patient already received suprapubic cystostomy or urethral catheterization. Participants with late-stage uremia and need regular dialysis. Participants with reasons like elevated serum creatinine, allergy to intravenous CT contrast media et al, and unable to undergo CTU.  Patient with cancer other than urothelial carcinoma.