Inclusion Criteria:  CML diagnosis by the WHO 2016 criteria Failure to reach cytogenetic response of Ph chromosome of 36 to 95% at 3 months or BCR/ABL <10% at 6 months of treatment with TKI Progression or relapse of the disease after previous response to treatment with TKI Validation of adherence to treatment Inform consent  Exclusion Criteria:  Lack of information to complete the register Failure to response achievement due lack of adherence to treatment