Inclusion Criteria:  Acute head lice infestation Age ≥ 6 months  Adequate informed consent for study participation:  Age-appropriate informed consent and verbal informed consent from the patient (if capable of both). Written informed consent from the legal guardian(s) (written and verbal).  Exclusion Criteria:  Adults (≥ 18 years of age) Known hypersensitivity to any component of the test or comparator product. Scalp lice therapy in the previous 2 weeks (with an appropriate drug or medical device). Severe disease of the scalp or injuries/open wounds on the hairy head Secondary infection in the area of the hairy head Treatment with cotrimoxazole or trimethoprim in the last 4 weeks or new treatment to be initiated now Other relevant reasons, e.g. diseases or dysfunctions, which, in the opinion of the investigator, militate against the inclusion of the patient in the study (including risk factors for severe COVID-19 disease in the case of SARS-CoV-2 infection) Simultaneous participation of another household member in the trial. Previous participation in this trial Participation in another trial within the last 30 days Inability of the legal guardian(s) to understand the study content and instructions. Limited legal capacity of the legal guardian(s) Apparent unreliability or unwillingness to cooperate on the part of the legal guardian(s) Known alcohol, medication or drug dependency of the legal guardian(s) Dependence of the patient or guardian on the sponsor or investigator.