Inclusion Criteria:  Ability to understand and the willingness to sign a written informed consent document； Aged between 18-75 years old; Histologically or cytologically confirmed advanced or metastatic malignant tumor; Presence of at least of one measurable lesion in agreement to RECIST criteria; Eastern Cooperative Oncology Group (ECOG) performance status 0 to 1; Life expectancy >12 weeks; Adequate organ performance based on laboratory blood tests; Women of childbearing potential and men must agree to use adequate contraception prior to study entry and for the duration of study participation.  Exclusion Criteria:  Patients who have received cytokines (IL-2, IFN-α)as anti-tumor therapy within 6 months before the first dose; Previous systemic therapy within 28 days before the first dose; Previous therapeutic surgery within 28 days, and diagnostic surgery within 14 days prior to the first dose; Received live attenuated vaccine within 28 days before the first dose, or expected to receive live attenuated vaccine during the study treatment period; Patients who received systemic immunosuppressive therapy within 14 days before the first dose; Patients with known or suspected brain metastasis； Subjects with interstitial pneumonia or interstitial lung disease, with a history of interstitial pneumonia or interstitial lung disease limiting self care ADL or with life-threatening respiratory compromise, with a history of pulmonary fibrosis, lasting pneumonia, drug- or radiation-induced pneumonia, and congenital pneumonia that may otherwise interfere with the judgement of immune-related pulmonary toxicity, or with any evidence of active pneumonia as shown on chest CT scans; Patients with history of autoimmune diseases; History of immunodeficiency (including HIV infection) or organ transplantation; Known active hepatitis B or C infection; Other serious accompanying illnesses, which, in the researcher's opinion, could seriously adversely affect the safety of the treatment.