Part 1 (HV Population):  Inclusion Criteria:  An informed consent document signed and dated by the subject. Healthy male and female subjects of any ethnic origin between the ages of 18 and 65 years, inclusive.  Exclusion Criteria:  Clinically relevant evidence or history of illness or disease. Pregnant or nursing females. History of febrile illness within 7 days prior to the first dose of study drug or subjects with evidence of active infection. A positive urine drug screen at screening or Day -1. Current tobacco smokers or use of tobacco within 3 months prior to screening. Any condition possibly affecting drug absorption (e.g., gastrectomy, cholecystectomy). History of regular alcohol consumption. Receipt of any vaccine, an investigational agent or biological product within 28 days or 5 times the t½, whichever one is longer, prior to first dose.  Part 2 (CHB Population)  Inclusion Criteria (Nuc-Suppressed CHB Population)  An informed consent document signed and dated by the subject. Healthy male and female subjects of any ethnic origin between the ages of 18 and 70 years, inclusive HBsAg detectable in serum/plasma at Screening and in the most recent HBsAg serum/plasma testing at least 6 months previously.  HBV DNA levels:  A Screening HBV DNA level in serum/plasma that is <LLOQ and No HBV DNA serum/plasma test values ≥LLOQ over the previous 12 months (using an approved test) CHB subjects must have been on their prescribed HBV NUC treatment with no change in regimen for 12 months prior to Screening  Inclusion Criteria (Viremic CHB Population):  An informed consent document signed and dated by the subject. Healthy male and female subjects of any ethnic origin between the ages of 18 and 70 years, inclusive HBsAg detectable in serum/plasma at Screening and in the most recent HBsAg serum/plasma testing at least 6 months previously.  HBV DNA levels:  For subjects who are HBeAg positive at Screening, a Screening HBV DNA level in serum/plasma that is ≥20,000 IU/ml, or For subjects who are HBeAg negative at Screening, a Screening HBV DNA level in serum/plasma that is ≥2,000 IU/mL, and For all subjects, no HBV DNA serum/plasma test values <1,000 IU/ml over the previous 12 months (using an approved test) CHB subjects must not have been on prescribed anti-HBV treatment, specifically pegIFN and/or NUC therapy for at least 12 months prior to Screening  Exclusion Criteria (Nuc-Suppressed and Viremic CHB Population):  A documented prior diagnosis of cirrhosis Pregnant or nursing females Coinfection with human immunodeficiency virus (HIV), HCV, HDV, HAV, or HEV Chronic liver disease of a non-HBV etiology; coexisting liver or biliary diseases