Inclusion Criteria:  Healthy male or female aged between 18 and 45 years old (including the critical value). The body mass index is in the range of 19-28 kg/m2 (including the critical value). The weight of male is not less than 50 kg, and that of female is not less than 45 kg (including the critical value). Subjects who had not any medical history of cardiovascular, digestive, respiratory, nervous or hepatic/renal impairment. The following examination show that the indicators are normal or abnormal without clinical significance. The examination including: physical examination, 12-lead ECG, vital sign measurements, and laboratory safety tests. The subjects have no family planning within 6 months and could select contraceptive method. Before the study, all subjects have been informed of the study's purpose, protocol, benefits, and risks, and signed the informed consent voluntarily. The subjects could complete the study according to the protocol.  Exclusion Criteria:  Being allergy to the study medications, smoking, alcohol abuse. Participation in another clinical trial within 3 months. Any history of hypersensitivity, needlesickness or idiosyncratic reactions to any food or drug; Any use of other prescription drugs (including contraceptive) 14 days prior to medication for this study; Any use of prescription or over-the-counter drugs, functional vitamin, herbal/ alcohol products, grapefruit-containing or caffeine/xanthine-rich food and beverages 48 h prior to medication for this study; dysphagia or having special dietary requirements; occurring acute disease in the screening period or before the medication lactating or pregnant women;