Inclusion Criteria:  American Society of Anesthesiologists (ASA) Class: I&II. Elective laparoscopic cholecystectomy. Age: 25-55 years. Gender: Both male and female. Body Mass Index (BMI): 18.5-24.9 km2-(Normal weight).  Exclusion Criteria:  Extremes of age. Abnormal hepatic function by alanine aminotransferase (ALT) and aspartate aminotransferase (AST) values outside the normal range. Abnormal renal function by blood urea nitrogen (BUN) and creatinine above the normal ranges. Hypertension, unstable angina pectoris or myocardial infarction within the last six months. Pregnancy and lactation. Bronchial asthma. Drug allergies. Alcohol or drug addiction. General anesthesia within the last three months.