Inclusion Criteria:  Persons with a doctor-confirmed diagnosis of idiopathic scoliosis; Persons of Kazakh nationality, whose paternal and maternal grandparents are Kazakhs; Hereditary history of scoliosis; Persons who are able and willing to provide written informed consent;  Exclusion Criteria:  Patients diagnosed with idiopathic scoliosis under 4 and over 40 years of age; Representatives of the Kazakh ethnic group less than 3 generations; No family history of bilateral idiopathic scoliosis; Patients with an acute period of the inflammatory process (laboratory and clinical signs); Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent; Pregnant or lactating women; Tuberculosis of any localization in the active phase and in history; Severe and decompensated diseases of the liver and kidneys, cardiovascular system; Severe and decompensated course of endocrine diseases; Autoimmune diseases; Systemic diseases; Oncological diseases;