Inclusion Criteria:  Documented HIV infection On continuous antiretroviral therapy and virologically suppressed HIV infection for ≥12 weeks prior to study entry CD4 T-cell count > 350 cells/mm3 Male or female between the ages ≥ 40 years of age to <≤75 Documented cardiovascular disease (1. Prior myocardial infarction, 2. History of percutaneous coronary intervention, 3. History of coronary artery bypass graft OR 4. Angiographic evidence of >50% stenosis in at least one coronary artery] OR 1 CVD risk factor (T2DM, current smoking, hypertension, dyslipidemia, hsCRP≥2mg/L, family history) TBR of >1.6 of the MDS of the carotid/aorta at baseline. This baseline arterial TBR cutoff excludes the rare individual that lacks appreciable arterial inflammation. It is notable that while 5-10% of uninfected individuals will have lower TBRs, it is rare that an HIV infected individual will fall below this range. Female subjects must either be of non-childbearing potential as defined by menopause with amenorrhea for >2 years, bilateral oophorectomy, or agree to use adequate contraception throughout the study and for at least one month following termination and have a negative pregnancy test at screening prior to the first dose of drug. Males must use at least one method of contraception throughout the study.  Exclusion Criteria:  Pregnant/nursing women Uncontrolled hypertension or diabetes requiring insulin AST/ALT or alkaline phosphatase >2x ULN Cancer within the last 5 years with exception of squamous cell carcinoma and basal cell carcinoma Nephrotic syndrome or eGFR <60 mL/min/1.73m2 Cytopenias which include 1) WBC <3.5 x103/uL 2) Platelet <120 x103/uL 3) ANC <1.5 x103/uL, and absolute lymphocytes <0.8 x 103/uL Anemia as fined by <10 g/dL Evidence of tuberculosis infection at screening within 30 days prior to screening. Family history of long QT syndrome, using medication that prolongs QT internal, OR evidence of prolonged QT of >470 msec as evidenced by ECG Acute systemic infection within 30 days On additional immunosuppressant or immunomodulatory therapies