Inclusion Criteria:  Participant is willing and able to give informed consent for participation in the study. Male or Female, aged 18 years or above. Diagnosed with solid tumour that requires surgical resection, and has a high propensity of relapse. Fit for planned surgical procedure. Able (in the Investigators opinion) and willing to comply with all study requirements. Willing to allow his or her General Practitioner, Consultant, and Clinical Geneticist, if appropriate, to be notified of participation in the study.  Exclusion Criteria:  Female participants who are pregnant, lactating or planning pregnancy during the course of the study. Not fit for surgery. Not willing to donate blood and tissue samples. Any other significant disease or disorder which, in the opinion of the Investigator, may either put the participants at risk because of participation in the study, or may influence the result of the study, or the participant's ability to participate in the study. Participants who have participated in another research study involving an investigational product in the past 12 weeks.