Inclusion Criteria:  Men and women, aged between 60-75 years Subjective cognitive decline (SCD) BMI between 25-35 kg/m2 Fasting plasma glucose < 7.0 mmol/L Fasting serum total cholesterol < 8.0 mmol/L (further testing will be performed for excessive hyperlipidemia [serum total cholesterol ≥ 8.0 mmol/L] according to the Standard for cardiovascular risk management of NHG) Fasting serum triacylglycerol < 4.5 mmol/L Systolic blood pressure < 160 mmHg and diastolic blood pressure < 100 mmHg Stable body weight (weight gain or loss < 3 kg in the past three months) Willingness to give up being a blood donor from 8 weeks before the start of the study, during the study and for 4 weeks after completion of the study No difficult venipuncture as evidenced during the screening visit  Exclusion Criteria:  Left-handedness Current smoker, or smoking cessation < 12 months Diabetic patients Familial hypercholesterolemia Abuse of drugs More than 3 alcoholic units per day Use of vitamin or mineral supplements known to interfere with the main outcomes as judged by the principal investigators within the previous 1-month Use of medication to treat blood pressure, lipid or glucose metabolism Use of an investigational product within another trial within the previous 1-month Severe medical conditions that might interfere with the study, such as epilepsy, asthma, kidney failure or renal insufficiency, chronic obstructive pulmonary disease, inflammatory bowel diseases, auto inflammatory diseases and rheumatoid arthritis Active cardiovascular disease like congestive heart failure or cardiovascular event, such as an acute myocardial infarction or cerebrovascular accident Contra-indications for MRI imaging (e.g. pacemaker, surgical clips/material in body, metal splinter in eye, claustrophobia)