Inclusion Criteria:  • Patients aged 18-64 years old with newly diagnosed positive H. pylori antigen in stools, urea breath test or H. pylori detected on endoscopy.  Exclusion Criteria:  • Women who were pregnant or lactating, patients previously treated with H. pylori eradication therapy, patients who previously underwent gastric surgery, patients with malignant neoplasms, and patients with other severe concomitant diseases like renal, hepatic impairement, heart failure NYHA class II or more, hypoalbuminemia will be excluded.  Known allergy to antibiotics.