Inclusion Criteria:  - Child-Pugh A or B cirrhosis. ECOG performance status (PS) Grade 2 or below. BCLC stage B or C. No serious concurrent medical illness. Radiologically or histologically proven HCC (an alpha-fetoprotein level > 500 ug/ml in the presence of radiological findings suggestive of HCC in a patient with chronic HBV or HCV infection is considered eligible). Unresectable and locally advanced disease without extra-hepatic disease. Nodular tumor morphology with measurable lesion on CT with less than 50% involvement of liver by HCC. Size of largest tumor is less than or equal to 15cm in largest dimension. Number of main tumor is less than or equal to 5, excluding associated small satellite lesions. Patent main portal vein.  Exclusion Criteria:  - Child-Pugh C cirrhosis (evidence of poor liver function). History of significant concurrent medical illness such as ischemic heart disease or heart failure. Serum creatinine level > 2 mg/dL. Presence of extrahepatic metastasis. Predominantly infiltrative lesion. Diffuse tumor morphology with extensive lesions involving both lobes. Hepatic artery thrombosis. Thrombosis of the main portal vein. Tumor invasion of portal branch of contralateral lobe.