Inclusion Criteria:  Age > 18 years; Signed informed consent; Histologically confirmed breast cancer  Exclusion Criteria:  Iodine allergy; Presence of distant metastases of breast cancer; Body mass index more than 40; Chronic cardiovascular and cerebrovascular diseases in the stage of decompensation or recent acute conditions (myocardial infarction, brain stroke, etc.) Suspected pregnancy; Severe hypothyroidism; Bronchial asthma in the stage of decompensation; Decompensated diabetes; Kidney or hepatic failure.