Inclusion Criteria:  Provision of signed and dated informed consent form Stated willingness to comply with all study procedures and availability for the duration of the study Male or female, aged 18-65 In good general health as evidenced by medical history and exhibiting upper facial wrinkles on physical examination Agreement to adhere to Lifestyle Considerations (see section 5.3) as appropriate throughout study duration  Exclusion Criteria:  Current use of aminoglycosides, curare like agents, and muscle relaxants Pregnancy or lactation Known allergic reactions to components of the botox formulation and any of its ingredients Treatment with another botox product for the face within 4 months Infections/preexisting weakness at the proposed injection sites on physical examination History of neuromuscular disorder, pre existing severe cardiovascular disease, compromised respiratory function, severe dysphagia Pediatric population, patients older than 65 since the effect of botox in terms of duration and magnitude is highly variable in these age groups.