Inclusion Criteria:  Patients naïve to GFD; With clinical history suggestive of malabsorption (weight loss, chronic diarrhea, iron-deficiency, anemia, etc.); And serologic suspicion of CD as positive or borderline antiendomysial (normal values are absent for both IgA and IgG) and antitransglutaminase antibodies (normal values 0-10 U/mL).  Exclusion Criteria:  Presence of severe gastrointestinal or systemic disease (e.g., chronic pancreatitis, liver cirrhosis, and blood coagulation disorders) impacts cardiovascular risk assessment. Presence of duodenal ulcer in the context of patients with upper gastrointestinal bleeding. History of any type of duodenal surgery. Pregnancy or nursing female. Refusal to participate in this observational trial.