Inclusion Criteria:  Meet the 2016 International Sepsis Guidelines diagnostic criteria (sepsis 3.0). Serum procalcitonin≥ 2 ng/mL at enrollment.  Exclusion Criteria:  Patients will be excluded if participants meet any of the following criteria:  age<18 years old or > 80 years pregnancy or lactation solid organ or bone marrow transplant advanced pulmonary fibrosis HIV-positive neutropenia; hematological/lymphatic tumors have no remission; limited care (lack of commitment to full and aggressive support); long-term use of immunosuppressive drugs or immunodeficiency; advanced tumors; combined with noninfectious factors leading to death (uncontrolled large bleeding, cerebral hernia, etc.); Combined with autoimmune diseases Paraquat poisoning Combined with Nasopharyngeal carcinoma Combined with chronic nasosinusitis Combined with severe nasal injuries