Inclusion Criteria:  Men and postmenopausal women Age 55 to 80 years old Meets NIA-AA criteria for probable AD dementia MMSE of 20-26 APOE ε4 positive Geriatric Depression Scale short form (GDS-S) score of ≤ 6 No medical contraindications to participation Capacity to provide informed consent at screening  Exclusion Criteria:  Dementia other than probable AD Use of benzodiazepines, anticonvulsants, antipsychotics, or other drugs that might interact with the GABA-A receptor complex History of stroke with a modified Hachinski Ischemic Scale score >4 History of seizure disorder, focal brain lesion, traumatic brain injury History within the last 5 years of a primary or recurrent malignant disease Unstable or clinically significant cardiovascular, kidney or liver disease MRI indicative of any other significant abnormality, including but not limited to one or more significant ARIA-E or macro-hemorrhage findings, or multiple microhemorrhages (>8), or Fazekas score of 3; encephalomalacia, aneurysms, vascular malformations, subdural hematoma, or space occupying lesions Any conditions that would contraindicate MRI studies.