Inclusion Criteria:  Concerning patients:  / Patients with suspected prostate cancer (MRI or digital rectal examination), or prostatic hyperplasia with a PSA level> 4 ng / ml / Patients with cancer detected after biopsy including 3 groups of 10 patients with Gleason score> = 8 (High Risk), 7 (intermediate Risk), or <= 6 (low risk) / Patients diagnosed by prostate MRI in the course of treatment / Information of the patient and signature of informed consent or his legal representative. / Participant affiliated to a social security scheme  Regarding healthy volunteers:  / Male from 50 to 70 years old / PSA level <4 ng / mL / No infectious episode in the week before the visit (in particular no urinary tract infection), documented by dipstick and the absence of fever / Absence of cancer and history of haematological pathologies (in particular leukemia, lymphoma). / Patient information and signature of consent  Exclusion Criteria:  1 / Participants who refused to participate in the biological collection 2) Persons deprived of their liberty or under guardianship. 3) Inability to undergo medical monitoring of the trial for geographical, social or psychological reasons.