Inclusion Criteria:  Patient age ≥ 18 y/o (No age limit due to cardiac variant Fabry IVS4 in Taiwan symptom of onset could be beyond 60 y/o) Patient with confirmed chronic kidney disease (CKD 1~5) diagnosis whose urine protein/creatinine (UPCR) is 150mg/g or above, or urine albumin/creatinine (ACR) is 30mg/g or above. Patient who are willing to sign inform consent form  Exclusion Criteria:  Patient who are unwilling to sign inform consent form Patient who received confirmed diagnosis of Fabry Disease Patient with known etiology of renal failure diagnosed with renal biopsy.