Inclusion Criteria:  1) Age≥18 years, regardless of sex; 2) Patients with a clinical diagnosis of acute ischemic stroke caused by large vessel occlusion of the anterior circulation (distal intracranial carotid artery, M1/proximal M2 or tandem lesion) cerebral artery confirmed by CTA or DSA and underwent mechanical thrombectomy; 3) Baseline NIHSS >= 6; 4) Baseline mRS ≤ 2； 5) Signed and dated informed consent is obtained.  Exclusion Criteria:  1) Patients who undergo intravenous thrombolysis; 2) Patients who had the contraindication of endovascular thrombectomy. 3) The patients who had the contraindication of remote ischemic conditioning treatment, such as severe soft tissue injury, fracture, or vascular injury in the upper limb. Acute or subacute venous thrombosis, arterial occlusive disease, subclavian steal syndrome, etc. 4) Head CT showed cerebral hernia and midline displacement. 5) Pregnant or lactating women. 6) Previous remote ischemic conditioning therapy or similar treatment. 7) Severe hepatic and renal dysfunction. 8) Patients with a life expectancy of less than 3 months or patients unable to complete the study for other reasons. 9) Unwilling to be followed up or treated for poor compliance. 10) He/She is participating in other clinical research or has participated in other clinical research or has participated in this study within 3 months prior to admission. 11) Other conditions that the researchers think are not suitable for the group.