Inclusion Criteria:  Participant is willing and able to give informed consent for participation in the study. Male or Female, aged 12 years or above. (Gillick Competent)  Exclusion Criteria:  The participant may not enter the trial if ANY of the following apply:  Participant who is pregnant, lactating or planning pregnancy during the trial. Significant hepatic impairment (determined by the PI) Scheduled elective surgery or other procedures requiring general anaesthesia during the trial. Participant with life expectancy of less than 6 months, or inappropriate for diagnostic monitoring through regular blood sampling. >3 months post-transplant Any other significant disease or disorder which, in the opinion of the Investigator, may either put the participants at risk because of participation in the trial, or may influence the result of the trial, or the participant's ability to participate in the trial. Participants who have participated in another research trial involving an investigational pharmaceutical product in the past 12 weeks. Multi-organ transplant (e.g., Kidney-Pancreas). Recipients of a transplant from a monozygotic (identical) twin Recipient of non-autologous bone marrow transplant Patients with a history of needle phobia. Patients who are not English or Spanish speaking