Inclusion Criteria:  Patients with periodontitis (stage III-IV); Patients with two or more periodontal pockets in different quadrants (bleeding on probing (BOP)>15% and probing pocket depth (PPD) ≥5mm; More than 30 years old; Patients should have not undergone any type of periodontal therapy 6 months prior to initial examination.  Exclusion Criteria:  An uncontrolled systemic disease; Patients had antibiotic therapy during the last 3 months prior to treatment or nonsteroidal anti-inflammatory drug use during the last 2 weeks; had periodontal treatment during last 6 months; pregnant or lactating women; allergies to the adjunct (proanthocyanidins).