Inclusion Criteria:  DEERS eligible Male or female, aged 18 to 70 years (inclusive) Presenting symptoms of shoulder pain caused by mild to moderate Shoulder OA as defined by Samilson Prieto criteria on a standard anterior-posterior (AP) Xray series BMI < 40 Willing and able to give voluntary informed consent to participate in this investigation Glenohumeral joint osteoarthritis that has been refractory to standard care treatments  Exclusion Criteria:  Patients who have received shoulder intraarticular or subacromial injection(s) in the last 3 months Patients who have undergone arthroscopic surgery on the study shoulder within the past year Patients who have undergone arthroplasty on the study shoulder Diabetes (Type 1 or II) Inflammatory arthropathies Fibromyalgia or chronic fatigue syndrome Female patient who is pregnant or nursing Patients taking narcotics Patients with planned deployment or separation from the military within 12 months Any other serious medical condition(s) that might preclude optimal outcome and/or interfere with participation such as intra-articular sepsis, bacteremia, fracture, joint instability, rheumatoid arthritis, osteoporosis, cancer, and coagulopathy Patients who have had an adverse reaction to a previous corticosteroid or PRP injection either documented in the medical record or shared by the patient during screening