Inclusion Criteria:  Age 18-75 years The diagnosis of liver cirrhosis based on imaging, laboratory and/or histological patameters from a board-certified hepatologist. Patients who underwent at least two abdominal CT examinations, and the interval between the first and the second check was more than one year. CT examination included the cross-sectional areas of muscle at L3 level. Basic patient data included age, gender, weight, height, biochemical examination, complications and 5-year survival. Biochemical examinations were available within 7 days before or after CT scan.  Exclusion Criteria:  patients with liver cancer and other malignant tumors. Patients accompanied by severe respiratory and circulatory diseases. Patients had a history of previous transplantation.