Inclusion Criteria:  Individuals over 18 years old With or without associated comorbidities: any pathology of the systems: cardiovascular, respiratory, endocrine, digestive, neurological, psychiatric, genitourinary Diagnosed with COVID-19 through RT-PCR (naso-oropharyngeal swab) Who agreed to participate in the research voluntarily  Exclusion Criteria:  Participants who refuse to participate in the survey Who have lesions in the oral mucosa that make the collection of material unfeasible Individuals with severe xerostomia In cancer treatment.