Inclusion Criteria:  Female patients 45 years of age or older who have had Oncoplastic Breast Surgery (OBS) or total mastectomy with adequate axillary clearance and a negative margin. Breast carcinomas that is invasive (TXN1-3M0, T0N2-3 M0, T1N2-3M0, T2N2-3M0, T3N0-3M0, T4N0-3M0) whatever type of tumors biology. All patients with locally advanced breast cancer who received neoadjuvant chemotherapy and underwent either oncoplastic breast surgery or modified radical mastectomy  Exclusion Criteria:  Metastatic breast cancer at the time of diagnosis proved clinically or radiologically. Postoperative positive margin. Carcinomas in situ. Mesenchymal breast lesions. Locoregional recurrent breast cancer. Synchronous bilateral breast cancer. very early breast cancer (T1-2N0M0,T1N1M0).