Inclusion Criteria:  ·age ranged from 16-70 years old body mas index over 28kg/m2  Exclusion Criteria:  secondary cause of obesity such as hypothalamic obesity, cushing syndrome, and hypophysis dysfunction, etc. pregnancy or lactation significant dysfunction of heart, liver, kidney and systemic organs (NYHA Class III or IV; alanine aminotransferase(ALT) and / or aspartate aminotransferase(AST) ≥ 5 times the normal upper limit; glomerular filtration rate< 60(ml/min) or with malignant tumor body weight fluctuated by more than 5 kg in the last 3 months with drug abuse or alcohol addiction with serious mental and neurological disorders blood pressure ≥ 180/110 mmHg, or malignant hypertension organic and systemic diseases intolerant of herb