Inclusion Criteria:  Aged >18 HIV infection  Disseminated TB confirmed by one or more of the following tests being positive  Lysed blood Xpert Ultra positive for MTB Concentrated urine Xpert Ultra positive for MTB Urine Alere LAM positive Hospital clinical team made decision to initiate TB treatment  Exclusion Criteria:  Pregnant or breastfeeding Active or recent SARS-CoV-2 infection TB treatment within the last 1 month or more than 2 doses of TB treatment Rifampicin resistance Neurological TB Receiving corticosteroids or other immunosuppressive therapy ALT >120 IU/L or total bilirubin >34 μmol/L Plasma CrAg positive or cryptococcal meningitis Current malignancy requiring active treatment (including any Kaposi sarcoma lesions) Patients established on ART with Protease Inhibitor based regimen who cannot be switched to a dolutegravir based regimen Diabetic ketoacidosis or Hyperosmolar Non-ketotic acidosis Any condition in the opinion of the investigator for which participation would increase risk to the patient