Inclusion Criteria:  Patients treated with standard therapy according to guidelines for sepsis Vasoplegic septic shock*, requiring NA ≥ 0.3 µg/kg/min despite adequate fluid resuscitation to maintain MAP ≥ 65 mmHg after at least 6 hours of guideline-oriented initial therapy Standard of care (SOC) shock treatment for >6 and < 24 hours Serum lactate >2 mmol/l at screening IL-6 ≥ 1000 ng/l at screening Indication for CRRT according to:  Kidney Disease Improving Global Outcomes (KDIGO) stage 2 AND/ OR Severe refractory metabolic acidosis after fluid resuscitation (HCO3<20 mmol/l and pH <7.20)9  Minimum 18 years of age Provide voluntary consent to participate in the study either directly or via a legally authorized representative (LAR) or in accordance to the procedure after determination of an emergency situation according to § 21 no. 3 sentence 3 MPG, as applicable  Exclusion Criteria:  Patients with an abdominal source of infection without a source control intervention within 6h of the determination of the indication OR a planned additional surgical intervention outside of ICU within the first 48 hours Patients with abdominal source of infection due to anastomotic leakage Septic shock for more than 24 hours prior to inclusion Need for use of first-line vasopressors other than NA Patients with a steroid therapy above Cushing-threshold dose (e.g. 30 mg hydrocortisone/d or 6 mg prednisolone/d) for more than 30 days prior to baseline Cytokine-specific antibody therapy before inclusion Anticipated interruption of CRRT and / or CytoSorb® 300 mL device therapy for more than 2 hours within the first 48 hours