Inclusion Criteria:  Clinical and imagine diagnosis of a first or recurrent unilateral stroke ≥ 3 months Finger flexor muscles spasticity (modified Ashworth scale of ≥ 1+) Initial motor part of UE of FMA score ranging from 10 to 56 indicating moderate to severe movement impairment No serious cognitive impairment (i.e., Mini Mental State Exam score > 20) Age ≥ 20 years  Exclusion Criteria:  Pregnant With bilateral hemispheric or cerebellar lesions Sever aphasia Significant visual field deficits or hemineglect Contraindication for BoNT-A injection Treatment with BoNT-A within 6 months before recruitment Any fixed joint contracture of the affected upper limb A history of orthopedic or other neurological diseases and/or medical conditions that would prevent adherence to the rehabilitation protocol