Inclusion Criteria:  Post-dural puncture headache (PDPH) after documented dural puncture with Tuohy needle during placement of epidural analgesia for labor and no other explanation for headache (HA). Onset of HA within 72 hours of delivery.  Exclusion Criteria:  Patient refusal. Visual analog scale (NRS) score < 4. History of migraine headaches. Asthma. Arrhythmia. Heart block. Myasthenia gravis. Inability to understand pain scores and other questionnaires. Inability to speak English. Contraindication to acetaminophen or NSAIDs. Temperature > 38.5 C. Prior EBP done for this HA.