Inclusion Criteria:  Type2 diabetes in treatment with metformin 30 kg/m2≤IMC≤40 kg/m2 30-70 years old HOMA-IR >6 Informed consent  Exclusion Criteria:  psychopathologic alterations that do not permit the adherence to the trial. Diabetes medication different from metformin. History of cholecystectomy. Use of Probiotics, and/or antibiotics in the last 3 months