Inclusion Criteria:  Diagnosis of Crohn's disease (CD) of at least 3 months in duration Have moderate to severe CD as assessed by CDAI, stool frequency, and abdominal pain score, and Simple Endoscopic Score for Crohn's disease (SES-CD). Demonstrated intolerance or inadequate response to conventional or to biologic therapy for CD  Exclusion Criteria:  Current diagnosis of ulcerative colitis or indeterminate colitis Complications of Crohn's disease that require surgical intervention or confound efficacy assessments Unstable doses of concomitant Crohn's disease therapy