Inclusion Criteria:  Aged from 50 to 80 years old; Patients diagnosed as acute ischemic stroke according to Chinese guidelines for the diagnosis and treatment of acute ischemic stroke 2018 and who met the requirements of middle cerebral artery blood supply area infarction (except deep perforator disease) without treatment; Brain MR showed that the low perfusion area of ASL was at least 20% larger than that of DWI core infarct area, and the contralateral mirror brain tissue was basically normal; NIHSS score was between 4 to 24; Patient or their legal representatives were willing to sign the informed consent form.  Exclusion Criteria:  Serious mental abnormality, complicated with heart, lung, liver, renal insufficiency or malignant tumor and other serious diseases; Combined with cerebral vascular malformation or cerebral hemorrhage; Pregnant or lactating women; Allergic to edaravone or dexborneol; There are interactions between the drugs being taken by patients and the study drug or affect the clinical trial parameters.