Inclusion Criteria:  men & women 50-75 years post-menopausal or women not of child-bearing potential diagnosis of Alzheimer's disease based on National Institute for Aging: Biomarker classification A+T+N+ or A+T+N- Clinical Stage 3 or 4 with Clinical Dementia Rating score >/= 0.5 & </= 1; mini-mental state examination (MMSE) score >/=20 Have an APOE genotype of E4/E4 or E3/E4 not on or on stabilized AD medication Patient & study partner willing to sign consent  Exclusion Criteria:  Other than AD, disorder that may impair cognition Contra-indication for MRI  History of neurological, psychiatric or mental conditions;  history stroke MI Type 1 diabetes & Type 2 with HbA1c>8% BP > 150/90 mmHg renal or hepatic impaired hyperaldosteronism cancer depression laboratory abnormalities not able to undergo lumbar puncture taking certain medications including lipid altering