Inclusion Criteria:  Participants eligible for inclusion in this study must meet all of the following criteria:  Signed informed consent must be obtained prior to participation in the study Males and females ≥18 years of age History of ASCVD, documented by hospital records, claims data and/or prior laboratory/imaging assessments Serum LDL-C ≥70 mg/dL or non-HDL-C ≥100 mg/dL Fasting triglyceride <5.65 mmol/L (<500 mg/dL) at screening Calculated glomerular filtration rate >30 mL/min by estimated glomerular filtration rate (eGFR) using standardized local clinical methodology Participants should be on maximally tolerated statin therapy, as determined by the investigator, with no immediate plans to modify lipid lowering therapies. Statin intolerant patients are eligible if they had documented side effects on at least 2 different statins, including one at the lowest standard dose Participants must be willing and able to give informed consent before initiation of any study related procedures and willing to comply with all required study procedures  Exclusion Criteria:  Participants meeting any of the following criteria are not eligible for inclusion in this study.  Any uncontrolled or serious disease, or any medical or surgical condition, that may either interfere with participation in the clinical study, and/or put the participant at significant risk (according to investigator's [or delegate] judgment) if he/she participates in the clinical study An underlying known disease, or surgical, physical, or medical condition that, in the opinion of the investigator (or delegate) might interfere with interpretation of the clinical study results New York Heart Association (NYHA) class III or IV heart failure or last known left ventricular ejection fraction <30% Significant cardiac arrhythmia within 3 months prior to randomization that is not controlled by medication or via ablation at the time of screening Major adverse cardiovascular event within 6 months prior to randomization Uncontrolled severe hypertension: systolic blood pressure >180 mmHg or diastolic blood pressure >110 mmHg prior to randomization despite antihypertensive therapy Severe concomitant non-cardiovascular disease that carries the risk of reducing life expectancy to less than 2 years History of malignancy that required surgery (excluding local and wide-local excision), radiation therapy and/or systemic therapy during the two years prior to randomization  Women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they are using basic methods of contraception during dosing of investigational drug. Basic contraception methods include:  Total abstinence (when this is in line with the preferred and usual lifestyle of the participant. Periodic abstinence (e.g., calendar, ovulation, symptothermal, post-ovulation methods) and withdrawal are not acceptable methods of contraception Female sterilization (have had surgical bilateral oophorectomy with or without hysterectomy), total hysterectomy or tubal ligation at least six weeks before taking investigational drug. In case of oophorectomy alone, only when the reproductive status of the woman has been confirmed by follow up hormone level assessment Male sterilization (at least 6 m prior to screening). For female participants in the study, the vasectomized male partner should be the sole partner for that participant Barrier methods of contraception: Condom or Occlusive cap (diaphragm or cervical/vault caps) Use of oral (estrogen and progesterone), injected or implanted hormonal methods of contraception or other forms of hormonal contraception that have comparable efficacy (failure rate <1%), for example hormone vaginal ring or transdermal hormone contraception or placement of an intrauterine device (IUD) or intrauterine system (IUS) In case of use of oral contraception, women should have been stable on the same pill for a minimum of 3 months before taking investigational drug.  Women are considered post-menopausal and not of child bearing potential if they have had 12 months of natural (spontaneous) amenorrhea with an appropriate clinical profile (e.g. age appropriate, history of vasomotor symptoms) or have had surgical bilateral oophorectomy (with or without hysterectomy), total hysterectomy or tubal ligation at least six weeks ago. In the case of oophorectomy alone, only when the reproductive status of the woman has been confirmed by follow up hormone level assessment is she considered not of child bearing potential.  Known history of alcohol and/or drug abuse within the last 5 years (occasional casual users of illicit drugs in the opinion of the investigators are not excluded) Treatment with other investigational products or devices within 30 days or five half-lives of the screening visit, whichever is longer History of hypersensitivity to any of the study treatments or its excipients or to drugs of similar chemical classes Planned use of other investigational products or devices during the course of the study  Any condition that according to the investigator could interfere with the conduct of the study, such as but not limited to:  Participants who are unable to communicate or to cooperate with the investigator Unable to understand the protocol requirements, instructions and study-related restrictions, the nature, scope, and possible consequences of the study (including participants whose cooperation is doubtful due to drug abuse or alcohol dependency) Unlikely to comply with the protocol requirements, instructions, and study-related restrictions (e.g., uncooperative attitude, inability to return for follow-up visits, and improbability of completing the study - including potential participants who indicate that their participation is contingent on receiving inclisiran) Have any medical or surgical condition, which in the opinion of the investigator would put the participant at increased risk from participating in the study Persons directly involved in the conduct of the study Previous or current treatment (within 90 days of screening) with monoclonal antibodies directed towards PCSK9 or ezetimibe Active liver disease defined as any known current infectious, neoplastic, or metabolic pathology of the liver or alanine aminotransferase (ALT) elevation >3x ULN, aspartate aminotransferase (AST) elevation >3x ULN, or total bilirubin elevation >2x ULN (except patients with Gilbert's syndrome) at screening confirmed by a repeat measurement at least one week apart