Inclusion Criteria:  Patients aged ≥18 years, including fertile women Blunt or penetrating trauma mechanism Direct transfer from the scene of accident to one of the participating trauma centers Trauma team activation The enrolling physician must initially expect a hospital length of stay for 24 hours or longer  Exclusion Criteria:  Patients in cardiac arrest before or on admission Patients with a suspicion of carbon monoxide intoxication Patients with no/minor injuries after secondary survey will be excluded if they are expected to be discharged <24 hours