Exclusion Criteria - All patients/participants  Participants in the diabetic wound group or healthy volunteer group will be excluded if any of the following criteria are met:  Less than 18 years of age History of hypersensitivity or allergy to tebipenem or its derivatives and any β-lactam antibiotic History of hypersensitivity to lidocaine or lidocaine derivatives Concurrently receiving probenecid.  Males who are not surgically sterilized (with female partners of childbearing potential) and females of childbearing potential must agree to use two highly effective methods of contraception from screening, during this trial, and for 90 days after the last dose of study drug. A woman is considered of childbearing potential unless postmenopausal (≥1 year without menses) or surgically sterilized via bilateral oophorectomy, hysterectomy, bilateral tubal ligation, or successful Essure® placement with a documented confirmation test at least 90 days after the procedure. Highly effective contraception is defined as a method of contraception that has a less than 1% failure rate when used consistently and correctly. These methods are as follows:  Hormonal contraceptives (eg, combined oral contraceptives, patch, vaginal ring, injectables, and implants). Intrauterine device or intrauterine system. Double-barrier methods of contraception (eg, male condom with diaphragm or male condom with cervical cap). Monogamous relationship with a vasectomized partner. Total abstinence, in accordance with the lifestyle of the subject. Any other documented reason felt by the investigator to potentially affect the outcomes of the study  Additional Exclusion Criteria for Diabetic Patient Study Group  Participants likely to require multiple surgical interventions during the study period, which could affect placement of the microdialysis catheter Creatinine clearance (CrCl) < 30ml/min, as calculated by Cockroft-Gault using ideal body weight  Additional Exclusion Criteria for Healthy Volunteer Control Group  Body Mass Index (BMI) ≥ 35 kg/m2 Creatinine clearance (CrCl) < 50ml/min, as calculated by Cockroft-Gault using ideal body weight Presence of anemia, thrombocytopenia, or leukopenia as defined by hematocrit, platelet, or white blood cell count < 75% of the lower limit of normal Aspartate transaminase, alanine aminotransferase, or alkaline phosphatase greater than five times upper limit of normal Total bilirubin greater than three times the upper limit of normal Any known active co-morbidity listed on medical history or that becomes apparent during physical examination Positive urine drug screen (cocaine, THC, opiates, benzodiazepines, and amphetamines) History of regular alcohol consumption exceeding 7 drinks/week for females or 14 drinks/week for men (1 drink = 5 ounces of wine or 12 ounces of beer or 1.5 ounces of hard liquor) within 6 months of screening. Use of tobacco- or nicotine-containing products in excess of the equivalence of 5 cigarettes per day. Consumption of caffeine between Study Days -1 and 2. Use of prescription or non-prescription drugs, vitamins, or dietary supplements within 7 days or 5 half-lives (whichever is longer) prior to the first dose of study medication, with the exception of acetaminophen at doses of ≤ 1 g/day. The use of hormonal methods of contraception (including oral and transdermal contraceptives, injectable progesterone, progestin subdermal implants, progesterone-releasing IUDs, postcoital contraceptive methods) are permitted.