Inclusion Criteria:  Having signed informed consent Age≥ 18 years old Histologically confirmed gastric adenocarcinoma Unresectable recurrent or metastatic disease Measurable disease according to the RECIST criteria Life expectancy of ≥3 month No prior chemotherapy of the study more than 4 weeks Immunotherapy regimens were included in the treatment  Exclusion Criteria:  Other previous malignancy within 5 year Surgery (excluding diagnostic biopsy) within 4 weeks prior to study Pregnancy or lactation period Legal incapacity