inclusion criteria for "cases" :  age 18 to 50 years premenopausal diagnostic of PCOS has been made according to Rotterdam criteria followed in the gynecology and endocrinology departments at the university hospital of Reims. agreeing to participate in the study  inclusion criteria for "controls"  age 18 to 50 years premenopausal diagnostic of PCOS can be excluded du to the absence of menstrual cycle disorders and absence of clinical signs of hyperandrogenism followed in the gynecology and endocrinology departments at the university hospital of Reims. agreeing to participate in the study  exclusion criteria:  under the of 18 years or over 50 years menopausal refusing to participate in the study protected by law