Inclusion criteria:  Major subject (≥18 years old) Having been seen at least once in consultation in the Internal Medicine, Endocrinology and Nutrition department of Hautepierre Hospital Subject operated for a pituitary adenoma at the HUS between 01/01/2000 to 09/01/2021 In whom biological confirmation of recurrence has been demonstrated Patient not having expressed his opposition, after information, to the reuse of his data for scientific research purposes.  Exclusion criteria:  Subject having expressed opposition to participating in the study Treatment pre and / or post surgery by radiotherapy No recurrence No treatment with a somatostatin analogue for recurrence Subject under guardianship, curatorship or safeguard of justice