Inclusion Criteria:  Type 2 diabetes mellitus patients with diabetic foot ulcers; Patients aged 18 to 79 years.  Exclusion Criteria:  Presence of autoimmune disease; Presence of psychiatric or cognitive disorders that impede the application of questionnaires; Pressure ulcers Venous ulcers; Contraindications to the treatment methods adopted in the research; Ulcers in other parts of the body than the feet; Diabetic foot ulcers infected.