Inclusion Criteria:  Patient with histologic diagnosis of non-small cell lung cancer The recommended treatment is thoracic radiation therapy combined with concurrent systemic therapy (chemotherapy and/or immunotherapy) with or without neoadjuvant and/or adjuvant systemic therapy (chemotherapy, immunotherapy, targeted therapy) >= 18 years of age Karnofsky performance status (KPS) >= 70 Willing and able to sign informed consents Able and willing to perform 6minute walking test Able and willing to preform required cardiac imaging examinations  Exclusion Criteria:  Unable or unwilling to give written informed consent Previous history of RT to the thorax Any contraindication for cardiac imaging Pregnant or breast-feeding Renal failure necessitating dialysis Unable to perform protocol tests Contraindication for any protocol tests