Inclusion Criteria:  18 years old or older; male and female patients Eaton-Glickel stage 2-3 thumb CMC arthritis Failed conservative treatment (i.e. hand therapy, pain medications, splinting) Able to provide informed consent  Exclusion Criteria:  Pregnancy/breastfeeding Inflammatory or posttraumatic arthritis Prior thumb base trauma or surgery Evidence of skin infection or soft tissue loss at the thumb CMC joint or adipose harvest site Active local or systemic malignancy Known allergy to any study drug