Inclusion Criteria:  Self-reported neck problems that the person experiences as troublesome, affecting ability to perform work, and lasting at least 4 weeks. Neck problems as being predominant. Current neck pain ≥ 3 on the numeric rating scale (0-10) [53, 55]. Persons of working age, 18-65 years, who have a permanent job. Neck problems clinically verified through a clinical examination to ensure study criteria are met. Answers the baseline questionnaire and attends the first intervention visit. Confirms being motivated to participate and completes and signs informed consent, including approval, to contact their immediate supervisor regarding a CDM.  Exclusion Criteria:  Red flags and illness/injury that are contraindicated for or hinder exercise or may be confounding factors for the results, such as severe cardiovascular/lung disease, malignancy, severe rheumatic disease, severe neurological disease, spinal cord injury, diagnosed severe mental illness, drug or alcohol abuse, neck surgery, neck fracture or dislocation, severe cervical radiculopathy, myelopathy, general body pain (e.g., fibromyalgia, Ehlers-Danlos syndrome, generalized osteoarthritis). Known pregnancy. Cannot understand/communicate in Swedish and thus would be unable to understand information in the study.  For blood samples (not wanting to participate does not constitute exclusion for the randomized controlled trial), the following exclusion criteria are added: increased tendency to bleed and use of blood thinners.  For the subgroup for microdialysis (n = 30, consecutively asked, 15 persons/group; not wanting to participate does not constitute exclusion for the randomized controlled trial), the following exclusion criteria are added:  Patients who cannot imagine refraining from non-steroid anti-inflammatory drugsduring 2 days before microdialysis may not participate in the microdialysis part of the study. Hypersensitivity to anesthetic and antibiotics. Increased tendency to bleed and use of blood-thinning drugs.