Inclusion Criteria:  Written informed consent from the patient. Age: 21-45 years old. Sex: both sex (males and females). Physical status: ASA 1& II. BMI = (25-35 kg/m2). Type of operation: elective laparoscopic cholecystectomy  Exclusion Criteria:  Altered mental state. Patients with known history of allergy to study drugs. Advanced hepatic, renal, cardiovascular, and respiratory diseases. Patients with chronic pain. Patients receiving anticoagulants. Contraindications of regional anesthesia, e.g., allergy to local anesthetics, coagulopathy, or septic focus at site of injection.