Inclusion Criteria:  Patient, men or women between 18 and 60 years-old Patient with a diagnosis of moderate to severe dependence (DSM 5) to cocaine with or without co-addictions to alcohol or psychostimulant. Patient on day-hospitalisation or full hospitalisation Patient affiliated or beneficiary to a social security scheme. Patient having signed the free and informed consent.  Exclusion Criteria:  Patient with psychiatric disorders psychosis type Patient with severe chronic somatic disease. Patient participating in another clinical study Protected patient: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision. Pregnant, breastfeeding or parturient woman. Patient hospitalized without consent.