Inclusion Criteria:  Caucasian ethnicity; Age between 30 and 65 years; Smokers who have smoked at least 100 cigarettes in their lifetime and smoke at least 10 cigarettes a day; Sportsmen who have been playing sports for at least 6 months between 4 and 8 hours per week; Signature of informed consent.  Exclusion Criteria:  Systemic pathologies; Active drug therapy; Estrogen-progestogen therapy; Pregnancy; Allergies to the components of the raw material under study.