Inclusion Criteria:  Male or female, age > 18 years old Patient requiring a primary or a secondary root canal treatment on a single or multi-rooted tooth. Informed consent signed Patient with social protection.  Exclusion Criteria:  Endodontic treatment on tooth with suspected root perforation, or immature tooth, Known allergy to corticosteroids, local anesthetics, or any component of the medical devices, Patient taking anti-pain or anti-inflammatory treatment regularly for another pathology, Presence of any significant medical finding or significant history such as uncontrolled systemic diseases that may impact the safety, the interpretation of the results and/or the participation of the subject in the study according to the opinion of the investigator, Participation in another intervnetional clinical trial or subject still within the exclusion period of a previous clinical trial, Vulnerable subjects referred to in articles L.1121-5 to 8 and L.1122-1-2 of the Public Health Code and article 66 of Regulation (EU) 2017/745 on medical devices are excluded from the investigation (such as known pregnancy or lactation, patients with legal protection).