Inclusion Criteria:  ECOG perfomance 0-1 pathologically confirmed colorectal carcinoma, with RAS wild type inital unresectable liver metastases discussed by MDT prior no systemical therapy or exceed 6 months after the adjuvant chemotherapy of primary tumor surgery. without extraheptic metastatic lesions, except for locally controlled lung metastases (RFA or SBRT) adequate blood, liver and renal function expected survival longer than 6 months  Exclusion Criteria:  with bleeding risk interestinal obstruction or disease uncontrolled hypertension and severe heart disease previous severe thrombotic events central nervous system metastases accompanied with other malignant tumor