Inclusion Criteria:  1. Patients were aged from 14 to 65 years; 2. Patients were diagnosed of acute leukemia or MDS; 3. There were indications of MSD-PBSCT for these patients; 4. Patients without any uncontrolled infections or without severe pulmonary, renal, hepatic or cardiac diseases.  Exclusion Criteria:  1. Patients with any uncontrolled infections or with severe pulmonary, renal, hepatic or cardiac diseases; 2. AML patients with t (15;17).