Inclusion Criteria:  Adults 18 to 65 years old height >160 cm fast weight >65 Kg Body Mass Index (BMI) >22.  Exclusion Criteria:  Diabetes vascular diseases liver diseases renal failure cancer chronic obstructive pulmonary disease (COPD) alcohol, drugs or tobacco addiction convulsive diseases hypothyroidism tuberculosis or chronic debilitating diseases use of statins or other lipid lowering drugs anticoagulants drugs herbal remedies. For women 18 to 50 years old, pregnancy should ruled out with a proper test before recruiting and anti conceptive measures must be started in case of active sexual life during all the time of the study and 2 additional weeks.