Inclusion Criteria:  Patient aged 18 and over, With isolated high-grade vulvar intraepithelial neoplasia OR associated with invasive cancer proven histologically by biopsy Naive of any vulvovaginal treatment (surgery or radiotherapy) No metastases WHO <or equal to 3 Contraception method for women of childbearing potential Patient affiliated to the social security scheme Patient who understood, signed and dated the information note and the consent form, Patient able and willing to follow all study procedures in accordance with the protocol.  Exclusion Criteria:  History of hypersensitivity to the active substance methyl aminolevulinate or to any of the components of the drug (including peanut oil and refined almond oil), soybean or peanut Ulceration or hyperpigmented lesions of the vulva Patient with porphyria Any previous vulvovaginal treatment (surgery or radiotherapy) Metastatic disease Patient undergoing treatment for any other invasive cancer Pregnant, likely to be or breastfeeding patient Patient deprived of liberty or under guardianship (including guardianship) Inability to undergo medical monitoring of the trial for geographic, social or psychological reasons. Patient already included in another therapeutic trial with an experimental molecule, Associated pathology that may prevent the patient from receiving METVIXIA application and light exposure.