Key Inclusion Criteria:  Patients are diagnosed with sepsis and receive study treatment within 48 hours Sepsis-related Organ Failure Assessment（SOFA）score range from 2 to 13 The informed consent form signed by the patient or the patient's legally acceptable representative  Key Exclusion Criteria:  Pregnant or breastfeeding women ; Women of childbearing potential (WOCBP) could not take effective method of contraception Moribund, and death is considered imminent within 24 hours or patient expected survival time is less than 6 months due to the underlying disease Absolute neutrophil count (ANC) <0.5 x 10^9/L New York Heart Association (NYHA) classification IV Patient with end-stage lung disease eGFR <60ml/min Alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) >3.0 times the upper limit of normal (ULN)  Immunosuppressed patients with following situations:  Human immunodeficiency virus (HIV) infection Patients undergoing active radiation or chemotherapy treatment within the past 3 months Any organ or bone marrow transplant and related immunosuppressive therapy High dose steroids (eg, > 0.5 mg/kg prednisone or a steroid with equivalent activity, daily for a month) within 3 months before provision of written informed consent for the study  Patients with high bleeding risk:  Recent surgery <72 hours, or a planned surgical procedure in the next 24h Severe thrombocytopenia (< 30 x 10^9/L, before platelet transfusion) Recent trauma <72 hours History of gastrointestinal bleeding or intracranial hemorrhage in the past 6 weeks. Stroke or head injury in the past 3 months On-going therapeutic anticoagulants that could not be interrupted (except prophylactic heparin treatment that can be continued） Any history of Chronic liver disease with a Child score B or C Any condition at risk of bleeding, as appreciated by the physician in charge of the patient Severe anemia (hemoglobin <5.9 g/dL)