Inclusion Criteria:  1. Photopic screening pupil diameter ≤ 3.5 mm in each eye  Exclusion Criteria:  Allergy to phenylephrine hydrochloride, tropicamide, or benzalkonium chloride. Use of benzodiazepines, monoamine oxidase inhibitors, tricyclic antidepressants, anticonvulsants, cholinergic drug at screening or anticipated during the study period. History of closed-angle glaucoma. Anatomically narrow anterior chamber angles (Van Herrick grade ≤ 2 in either eye). Ocular surgery or laser treatment of any kind prior to the Screening Visit. History of iris trauma, surgery, or atrophy. Irregularly-shaped pupil secondary to ocular trauma or congenital defect, or history of neurogenic pupil disorder.