Inclusion Criteria:  Age > 18 Life expectancy > 3 months Brain metastases number ≥ 5 Primary tumor histologic diagnosis Complete Extracranial staging Montreal Cognitive Assessment ≥ 20/30 Barthel Activities of Daily Living ≥ 90/100 KPS ≥ 70 Signed Informed Consent  Exclusion Criteria:  Brain-MRI contraindications Contraindications to SRS Pregnancy Hemorrhagic cerebral disease Miliary metastases Massive perilesional edema Leptomeningeal involvement Previous brain irradiation Dementia Non-solid brain tumor Ischaemic event Alcohol and/or drugs abuse Anxiety and depression KPS ≤ 60 Life expectancy < 3 months