Inclusion Criteria:  Patients 18 years of age and older Patients who had received a solid organ (kidney, liver, lung, heart, and pancreas) transplant patient from living or deceased donors. Patients with active graft with at least one immunosuppressive medication Completed two doses of BNT162b2 vaccination at least 28 days ago  Exclusion Criteria:  Patient with non-active graft Any significant side effect with previous COVID-19 vaccination Within 28 days of BNT162b2 vaccine completion Already received more than and equal to three doses of COVID-19 vaccination Previously received COVID-19 vaccine other than BNT162b2 vaccine Previously received monoclonal Antibody treatment that are specifically directed against the spike protein for SARS-CoV-2 such as Mab, Bamlanivimab, etesevimab, Casirivimab, imdevimab, Sotrovimab and/or any combination. Thrombocytopenia (if less than 50,000 per microliter 30 days prior vaccination) History of Capillary Leak Syndrome Adults unable to consent Individuals who are not yet adults (younger than 18 year old) Vulnerable patients (prisoners) Pregnant women