Inclusion Criteria:  Healthy volunteers who signed informed consent form Age ≥ 18 years and ≤ 40 years, male or female, Han nationality. Weight: male ≥ 50 kg, female ≥ 45 kg; 18.5 ≤ BMI ≤ 30. Temperature: 36.3-37.2℃ (Forehead temperature).  Exclusion Criteria:  Those with known respiratory, circulatory, digestive, urinary, blood, immune, endocrine disorders or metabolic disorders, neurological diseases, mental illnesses and those with a family history; Those with known chronic skin diseases, especially infectious, allergic or inflammatory systemic skin diseases; Those with known allergic diseases or recurrent allergies; Those with known malignant tumors or health-affecting benign tumors; Two or more physical examination results of blood pressure have shown (except for white coat hypertension): systolic blood pressure < 90 or ≥140mmHg, or diastolic blood pressure < 60 or ≥ 90 mmHg, or pulse pressure < 30 mmHg, heart rate: < 60 beats/min or >100 beats/min; Laboratory tests: hemoglobin is abnormal and has clinical significant; liver and kidney function are higher than the normal upper limit and have clinical significance; 12-lead ECG is abnormal and has clinical significance, or abdominal ultrasound is abnormal and has clinical significance, or chest X-ray is abnormal and has clinical significance; abnormal coagulation function; increased CRP; Those with active or latent hepatitis B or active hepatitis C, or Treponema pallidum antibody, or human immunodeficiency virus antibody, or anti-EBV IgM antibody, or anti-CMV IgM antibody, or COVID-19 DNA ; Recipients of allogeneic tissue and organ or hematopoietic stem cell transplants; Those who have undergone resection of vital internal organs such as stomach, kidney, spleen and lung; Those who have undergone minor surgery within last 3 months, such as appendectomy and ophthalmic surgery; those who have undergone major surgery within 1 year, such as surgical treatment for gynecological benign tumors or superficial benign tumors; Women who are pregnant, or have an abortion within last 6 months or gave childbirth within 1 year; Those whose upper respiratory tract infection has recovered for less than 1 week, or pneumonia has recovered for less than 3 months; Those whose acute pyelonephritis has recovered for less than 3 months, or those with acute exacerbation of urinary calculi; Those who have been injured or wound-contaminated by equipment contaminated by blood or tissue fluids, or who have got a tattoo for less than 1 year; Those who have received whole blood and blood component transfusion within 1 year; Those who have received the last dose of live attenuated vaccines within 2 weeks, or have received the last dose of rubella live vaccine within 4 weeks; Those who have received the last dose of rabies vaccines after being bitten by an animal within 1 year; Those who have received the last dose of antitoxin or immune serum injection within 4 weeks, or those who have received the last dose of hepatitis B human immunoglobulin injection within 1 year; Those who have participated in clinical trials within 3 months, or try to participate in other intervention trials during the study. Those who are considered by the investigator as unsuitable for participating in the study.