Inclusion Criteria:  Female adult (age 18-80) Patients planned for immediate or delayed DIEP/MS-TRAM breast reconstruction  Exclusion Criteria:  Patients who are unable to consent or do not consent Clotting disorder Pregnancy Individuals whose immune system is depressed or who have some types of anaemia (e.g. sickle cell disease or haemolytic anaemia). COVID positive Known previous allergic reactions to ARTISS