Inclusion Criteria:  Confirmed diagnosis of spontaneous, non-traumatic ICH. 10 mL ≤ ICH ≤ 60 mL (confirmed via diagnostic and stability CT scans utilizing volumetric assessment) Participants receiving anticoagulants are eligible upon reversal and stability within 24hrs after onset of ICH symptoms Age ≥ 18 years Able to receive first dose of test article ≤ 24h after onset of ICH symptoms NIHSS score ≥ 2 at randomization or Glasgow Coma Scale ≥ 5 at randomization Controlled blood pressure (systolic BP < 180 mm Hg) at randomization. Premorbid magnetic resonance spectroscopy (mRS) of 0-2 Has adequate venous access No planned surgical intervention except EVD Written informed consent from the patient or legally authorized representative (LAR)  Exclusion Criteria:  Unstable hematoma defined as > 6 mL increase as compared to previous CT volume taken at least 6 hours apart within 24 hrs after onset of ICH symptoms. Anticipated neurosurgical evacuation by open surgery or minimally invasive surgery with or without Alteplase (EVD allowed). Uncontrolled temp >38.5˚C at enrollment. Signs of intracranial infection or emergence of a systemic infection Is pregnant or lactating Signs of liver and kidney chronic disease (i.e. creatinine >2, bilirubin > 3, receiving dialysis) Non-reversible bleeding diathesis Used any chronic immunosuppressants or chronic anti-inflammatory drugs (excluding low-dose aspirin), by any route of administration within the past 7 days. Anticipated withdrawal of life-sustaining therapies within the first week after admission. In the opinion of the investigator, patient has any contraindication to the planned study assessments. In the opinion of the investigator, patient has a condition that could interfere with the proposed treatment or unacceptably increase the individual's risk by participating in the study. Concomitant enrollment in another acute interventional study