Inclusion Criteria:  Age>=18Y Good Organ Function Expected survival time ≥ 3 months Refractory primary brain tumors with BRAF mutation that have been diagnosed Unable to receive surgery/radiotherapy, or have treatment failed after surgery/radiotherapy ECOG score 0-1;  Exclusion Criteria:  Previous treatment with BRAF inhibitors or MEK inhibitors A history of other malignancies within two years, except for cured cervical carcinoma in situ, basal cell carcinoma of the skin, adenocarcinoma in situ of the lung, or tumors that do not require interventional treatment after radical surgery Severe active infections requiring systemic anti-infective therapy Other anti-tumor treatments, such as chemotherapy, targeted therapy, or radiation therapy (except palliative radiation therapy), may be given during the study period.