Inclusion Criteria:  Group 1  Healthy donors (HD) who had recovered from COVID-19 disease and/or HD who did not have COVID-19 disease in the past and who will receive the COVID-19 vaccine or a COVID19 vaccine candidate or other protective vaccines HD who did receive one dose of a specific COVID19 vaccine but who will receive a different vac-cine for her/his second vaccination for completion of the immunization Age > 18 years  Group 2  Vaccinated subjects who are diagnosed with central thrombosis, anaphylactic shock or other major or minor complications such as atopic dermatitis (for example) after vaccination. Age > 18 years  Exclusion Criteria:  Group 1 and 2  - Missing informed consent of the subject