Inclusion Criteria:  Patient adult age 18years and over(higher incidence) presented to Assiut University Hospital from 1december2020 to 30march.2021(winter2021-second wave) Suspected of covid19 beacuse of the presence of symptoms suggestive of pneumonia (fever>38) and at least one of the following symptoms ;cough, dyspnea, tachpnea or hypoxia having undergone RT-PCR (confirmed positive PCR) Chest CT within 5 days of initial PCR  Exclusion Criteria:  Cases less than 18 years old Cases express a dissent from the use of their data in the syudy Cancer patients (affect result of study as they have disrubted level of these biomarker)