Inclusion Criteria:  Aged >18 years old. Non-severely disabling initial ischemic stroke (mRS≤3) in the last 90 days. With diagnosis of severe periodontitis (generalized stage III-IV). Presence of at least 10 teeth in the mouth.  Exclusion Criteria:  Patients receiving periodontal treatment in the last 12 months. Stroke due to intracranial hemorrhage, dissection, veno-occlusive disease, drugs, trauma or vasculitis. Previous neurological impairment that would make detection of a subsequent event difficult. Comorbidities that may limit survival <12 months. Brain CT/MRI that shows a lesion other than stroke as a cause of syndrome. History of medical conditions requiring antibiotic prophylaxis prior to dental exam. Pregnants or breastfeeding. Known allergy or hypersensitivity to local anesthesia thst cannot be medically managed. Patients with bleeding disorders or