Inclusion Criteria:  aged 18 to 65 years, of either sex patients with a diagnosis of Hp infection patients who have failed treatment for Hp infection not taking acid-suppressing medications (PPI or H2 blockers) within the last 2 weeks who have not used antibiotics and/or bismuth within the last 4 weeks understand and are willing to participate in this clinical trial and provide a signed informed consent form.  Exclusion Criteria:  those with a history of drug allergy those with severe cardiac, hepatic, pulmonary, and renal insufficiencies those with a recent history of gastrointestinal hemorrhage, obstruction, perforation, tumors, and other serious organic diseases of the gastrointestinal tract those with mental illness, psychological disorders that cannot be expressed normally those who are pregnant, lactating, or planning to have children in the near future during the study period. those who are not suitable for clinical trials and those who cannot cooperate