Inclusion Criteria:  Informed consent: Subject's written informed consent obtained prior to any study related procedures; Gender and age: Male or female subjects aged ≥ 18 and ≤ 75 years; Diagnosis of asthma: A documented diagnosis of permanent asthma for at least 1 year according to GINA recommendations (Box 1-2, GINA report 2021), and with diagnosis before the subject's age of 40 years; Stable asthma therapy: a stable treatment with medium dose of Inhaled corticosteroids (ICS) (extrafine BDP daily dose > 200 and ≤400 µg or estimated clinically comparable dose, as described in GINA 2021 box 3-6) plus a long-acting ß2-agonist (LABA) (formoterol 24 µg or salmeterol 100 µg or vilanterol 25 µg or other approved dose of LABA as clinically comparable to the others) for at least 4 weeks prior to screening; Lung function: A pre bronchodilator FEV1 < 80% of the predicted normal value, after appropriate washout from bronchodilators, at the screening and randomization visits; Reversibility of bronchoconstriction: A demonstrated increase in FEV1 > 12% and > 200 mL over baseline within 30 minutes after inhaling 400 µg of salbutamol pMDI (based on ATS/ERS guidelines); A Post-bronchodilator FEV1/FVC ratio ≥ 0.5 within 30 minutes after inhaling 400 µg of salbutamol pMDI at screening (based on ATS/ERS guidelines); Poor Asthma control: Evidence of poorly controlled or uncontrolled asthma as based on an Asthma Control Questionnaire© (ACQ-7) score ≥ 1.5 at screening and at randomization; History of exacerbations: A documented history of one or more asthma exacerbations requiring treatment with systemic corticosteroids or emergency department visit or inpatient hospitalization in the last 3 years prior to screening;  A cooperative attitude and ability:  to correctly use the pMDI inhalers; to perform all trial related procedures including technically acceptable pulmonary function tests; to correctly use the e-Diary/e-Peak flow meter and home-spirometry device.  Female subjects:  a. Woman of Childbearing Potential (WOCBP) fulfilling one of the following criteria: i. WOCBP with fertile male partners: they and/or their partner must be willing to use a highly effective birth control method from the signature of the informed consent and until the follow-up call or ii. WOCBP with non-fertile male partners (contraception is not required in this case).  or b. Female patient of non-childbearing potential defined as physiologically incapable of becoming pregnant (i.e. post-menopausal or permanently sterile. Tubal ligation or partial surgical interventions are not acceptable. If indicated, as per investigator's request, post-menopausal status may be confirmed by follicle-stimulating hormone levels (according to local laboratory ranges).  Exclusion Criteria:  Pregnant or lactating woman where pregnancy is defined as the state of a female after conception and until termination of the gestation, confirmed by a positive pregnancy test (serum pregnancy test to be performed at screening visit and urine pregnancy test to be performed prior to randomization); Run-in compliance to study drug and e-Diary completion < 50% at randomization; History of "at risk" asthma: History of near fatal asthma or of a past hospitalization for asthma in intensive care unit which, in the judgement of the Investigator, may place the subject at undue risk;  Recent exacerbation: hospitalization, emergency room admission or use of systemic corticosteroids for an asthma exacerbation in the 4 weeks prior to screening visit or during the run-in period;  Note: Subjects experiencing an exacerbation during the run-in period may be re-screened once, at least 4 weeks after recovery.  Non-permanent asthma: exercise-induced, seasonal asthma (as the only asthma-related diagnosis) not requiring daily asthma control medicine; Subjects using systemic corticosteroid medication in the 4 weeks or slow release corticosteroids in the 12 weeks, prior to screening; Asthma requiring use of biologics: Subjects receiving asthma treatment with an injectable biologic drug such as monoclonal antibodies; Respiratory disorders other than asthma: Subjects with known respiratory disorders other than asthma. This can include but is not limited to: diagnosis of COPD as defined by the current guidelines (e.g. GOLD Report), known α1-antitrypsine deficiency, active tuberculosis, bronchiectasis, sarcoidosis, lung fibrosis, pulmonary hypertension and interstitial lung disease; Lung cancer or history of lung cancer: Subjects with an active diagnosis of lung cancer or a history of lung cancer; Lung resection: Subjects with a history of lung volume resection; Respiratory tract infection: Subjects with respiratory tract infection within 4 weeks prior to screening or during the run-in period; Note: Subjects experiencing a respiratory tract infection during the run-in period may be re-screened once, at least 4 weeks after recovery. Smoking status: Current smoker or ex-smoker with a smoking history of ≥ 10 pack-years (pack-years = the number of cigarette packs per day times the number of years). Ex- smokers must have stopped smoking for ≥1 year (≥ 6 months for e-cigarettes). Cancer or history of cancer (other than lung): Subjects with active cancer or a history of cancer with less than 5 years disease free survival time (whether or not there is evidence of local recurrence or metastases). Localized carcinoma (e.g. basal cell carcinoma, in situ carcinoma of the cervix adequately treated, …) is acceptable; Cardiovascular diseases: Subjects who have clinically significant (CS) cardiovascular condition according to Investigator's judgement, such as but not limited to: congestive heart failure (NYHA class IV), unstable or acute ischemic heart disease in the last year prior to screening, history of sustained and non-sustained cardiac arrhythmias diagnosed in the last 6 months prior to screening (sustained meant lasting more than 30 seconds or ending only with external action, or led to hemodynamic collapse; non-sustained meant > 3 beats < 30 seconds, and or ending spontaneously, and or asymptomatic), high degree impulse conduction blocks (> 2nd degree atrioventricular block type 2),persistent, long standing or paroxysmal atrial fibrillation (AF); Note: Subjects with permanent AF (for at least 6 months prior screening) with a resting ventricular rate < 100/min, controlled with a rate control strategy (i.e. selective β blocker, calcium channel blocker, pacemaker placement, digoxin or ablation therapy) can be considered for enrolment; ECG criteria: Any abnormal and clinically significant 12-lead ECG that in the investigator's opinion would affect efficacy or safety evaluation or place the subjects at risk. ECG QTcF: Male subjects with a Fridericia's corrected QT interval (QTcF) >450 msec and female subjects with a QTcF >470 msec at screening are not eligible (not applicable for subjects with permanent atrial fibrillation and for subjects with pacemaker); Subjects with a medical history or current diagnosis of narrow angle glaucoma, symptomatic prostatic hypertrophy, urinary retention bladder neck obstruction that, in the opinion of the Investigator, would prevent use of anticholinergic agents; Note: Benign prostatic hyperplasia subjects who are stable under treatment can be considered for inclusion. CNS disorders: Subjects with a history of symptoms or significant neurological disease such as but not limited to transient ischemic attack (TIA), stroke, seizure disorder or behavioral disturbances according to the investigator's opinion; Other medical conditions: Subjects with other severe acute or chronic medical or malignancy or psychiatric condition or clinically significant laboratory abnormalities indicating a significant or unstable concomitant disease, that might in the judgment of the Investigator, place the subject at undue risk or potentially compromise the results or interpretation of the study; Other concurrent diseases: Subjects with historical or current evidence of uncontrolled concurrent disease such as but not limited to hyperthyroidism, diabetes mellitus or other endocrine disease; hematological disease; autoimmune disorders (e.g. rheumatoid arthritis, ), gastrointestinal disorders (e..; poorly controlled peptic ulcer, GERD), significant renal and hepatic impairment or other disease or condition that might, in the judgement of the investigator, place the subject at undue risk or potentially compromise the results or interpretation of the study; Liver diseases: Subjects with severe hepatitis, chronic active hepatitis or evidence of uncontrolled chronic liver disease according to the investigator's opinion; Vaccination: Subjects who receive a vaccination within 2 weeks prior to screening or during the run-in; Subjects mentally or legally incapacitated, or subjects accommodated in an establishment as a result of an official or judicial order; Contra-indications to IMPs: Contra-indications to IMPs constitute an exclusion criterion. For warnings, eligibility will be judged by the investigator; Alcohol/drug abuse: Subjects with a history of alcohol or drug abuse within two years prior to the start of the study; Hypersensitivity: Subjects with known intolerance/hypersensitivity or contraindication to treatment with ß2-agonists, ICS, anticholinergics or propellant gases/excipients. For warnings/precaution for use, eligibility will be judged by the investigator; Surgery: Subjects with major surgery in the 3 months prior to screening visit or planned surgery during the trial; Subjects treated with non-potassium sparing diuretics (unless administered as a fixed dose combination [FDC] with a potassium conserving drug or changed to potassium sparing before the screening), nonselective beta blocking drugs, quinidine, quinidine like anti-arrhythmics, or any medication with a corrected QT interval (QTc) prolongation potential or a history of QTc prolongation; Subjects treated with monoamine oxidase inhibitors (MAOIs) and tricyclic anti-depressants; Subjects receiving any therapy that could interfere with the study drugs according to Investigator's opinion; Participation to investigational trial: Subjects who have received an investigational drug within 2 months or six half-lives (whichever is greater) prior to screening visit, or have been previously randomized in this trial, or are currently participating in another clinical trial; Documented COVID-19 diagnosis or its complication which has not resolved within 14 days prior to screening.