Inclusion Criteria:  Age 18 or older Speaks and reads English Verified HIV+ status with antiretroviral medications bearing his/her name Current diagnosis on Major Depressive Disorder (MDD) using a structured clinical interview If prescribed antidepressants, on a stable regimen and dose for at least 2 months Clinically elevated C-Reactive Protein (CRP) of > 3 mg/L Undetectable HIV viral load from peripheral venous blood sample Able to complete Functional Magnetic Resonance Imaging (fMRI) scans (i.e., no claustrophobia, no metal implants, no pacemaker, and BMI < 40)  Exclusion Criteria:  Unable to provide informed consent Active, untreated major mental illness Pregnancy at baseline Received CBT for depression in the past 2 years Otherwise eligible but does not complete baseline biospecimen collection and fMRI visit