Inclusion Criteria:  It is known that patients with T2DM has a history of more than 12 months (the WHO1999 Standard) and is treated with at least one anti-diabetic agent. Gender and age: men and women who are at least 18 years old with informed consent. Patients are willing and able to provide written informed consent before participating in this study.  Exclusion Criteria:  Type 1 diabetes mellitus (DM) Patients with severe ketosis, diabetic coma, severe infection or severe trauma Perioperative patients Patients with severe renal impairment and advanced nephropathy (eGFR < 45 ml/min/1.73m2) Renal transplant patients Patients are participating in or have participated in any other clinical trials in the past 3 months Any disease with a life expectancy of less than 2 years according to the clinical judgment of the investigator Pregnant or lactating women Patients judged by the investigator to be unsuitable for participating in the study.