Inclusion Criteria:  Patients aged one to five years old presenting to primary care or emergency department or urgent care centre or identified from primary care records and have been diagnosed with wheezing by their GP or paediatrician who has decided to prescribe any bronchodilator, ICS or montelukast on clinical grounds Parents/Carers able to understand and familiarize themselves with the study and are willing to provide informed consent  Exclusion Criteria:  Inability to understand and cooperate with study procedures Significant co-morbidity (respiratory or otherwise), for example cystic fibrosis (excluding atopic disorders such as eczema, allergic rhinitis and food allergy) Withholding or withdrawal of informed consent Severe procedural anxiety (needle phobia) Child is already enrolled in another study involving investigational medicinal product (CTIMP) History of anaphylaxis or near-fatal asthma that resulted in intubation / assisted ventilation.