Inclusion Criteria:  Patients age 18 or older on the day of the procedure Undergoing cardiac or vascular interventional procedures for diagnostic angiography, coronary intervention, TAVR or TAVI, with planned use of radiocontrast media within the next 30 days Able to provide informed consent Available to participate in follow-up visits eGFR < 45 within the last 90 days, or eGFR < 60 within the last 90 days with at least one (1) of the following risk factors: Diabetes Heart failure (acute or chronic) Anemia (hemoglobin < 12 g/dL for females and < 13 g/dL for males) within the last 90 days Age > 75 on the day of the procedure  Exclusion Criteria:  Patient on dialysis or with eGFR < 15 within the last 30 days History of renal transplant Current use of immunosuppressive drugs other than prednisone < 10 mg/day Current clinically significant infection (including HIV, hepatitis) Presence of KDIGO Stage 1, 2, or 3 AKI within the last 7 days, according to KDIGO criteria Known or suspected nephritic or nephrotic syndrome. A current post-renal etiology of renal impairment Known allergy or hypersensitivity to radiographic contrast dye that cannot be pre-medicated Females that are known to be pregnant or nursing Participation within the last 30 days in another clinical trial involving use of any drug known to affect AKI and/or device known to affect AKI