Inclusion Criteria:  Participants diagnosed with high-risk polyps in the colorectal cancer screening programme or in the relative's colon cancer prevention program or patients who are in follow-up due to prior detection of polyps with any of the following characteristics:  At least 10 adenomas At least 5 proximal serrated polyps (PSP) At least 2 serrated polyps with diameters ≥10 mm Serrated Polyposis Syndrome (SPS) Early invasive CRC (stage pT1) endoscopically resected (surgery not required) A sessile or flat lesion ≥ 20 mm with fragmented resection Patients with previous resection of polyps in which the resection margin was not assessable and are considered susceptible to repeat colonoscopy Regular consumer of milk and dairy products. Informed consent form signed.  Exclusion Criteria:  History of allergic reaction attributed to compounds of similar chemical composition to the study agents. Incomplete colonoscopy or with poor quality criteria, Boston <6. Concomitant acetylsalicylic acid (ASA), NSAIDs, misoprostol, corticosteroids or statins needed on a regular or predictable basis during the time of the study. Previous gastrointestinal surgery (colon or small intestine or gastric) that affects the absorption of nutrients. History of familial adenomatous polyposis.