Inclusion Criteria:  Pregnant women between 23+0 weeks and 34 weeks gestation. Admitted with signs and symptoms of threatened PTL with positive fetal fibronectin of 200ng/mL or clinical confirmation of preterm rupture of membranes Singleton pregnancy The ability to understand and sign a written informed consent form, prior to participation in any screening procedures and must be willing to comply with all study requirements.  Women must be aged 18 years or older.  -  Exclusion Criteria:  Chorioamnionitis: Defined as maternal temperature was elevated to 37.8°C and two or more of the following criteria were present: uterine tenderness, malodorous vaginal discharge, maternal leucocytosis (>15 000 cells/mm3), maternal tachycardia (>100 beats/min) and fetal tachycardia (>160 beats/min). Multiple pregnancy Uterine contractions >2:10 and evidence on tocogram Maternal infections such as HIV and hepatitis Clinical suspicion of placental abruption Evidence of meconium stained liquor Fetal abnormality or growth restriction Abnormal fetal heart rate pattern  Maternal pathologies in which preterm termination of pregnancy is required.  -