Inclusion Criteria:  Patient with non-specific chronic low back pain for at least 3 months; A pain intensity of at least 5 points measured by 0 -10 points pain rating scale; Co-morbidity - IHD and/or CHF and/or COPD and/or chronic bronchitis) Willing and able to consent, complete all assessment and study procedures;  Exclusion Criteria:  Specific types of back pain (metastatic cancer or bone cancer or secondary cancers, vertebral fractures, spinal infection, active inflammatory disease); Low back surgery within past 3 months; Serious cardiovascular, cerebrovascular, neuromuscular and other systemic diseases or other diseases affecting physical activity; Any significant systemic illness or medical condition that could affect safety or compliance with study; Major active or chronic unstable psychiatric illness (e.g. depression, bipolar disorder, obsessive compulsive disorder, schizophrenia) within the previous year; Tumour disease except being successfully treated and off treatment with >2 years. Tumour disease except being successfully treated and off treatment with >2 years. Use of other investigational agents or interventions one month prior to entry and for the duration of the trial;