Inclusion Criteria:  type 2 diabetes complicated by diabetic nephropathy (first group), non-diabetic nephropathy (second group) or healthy subjects Angiotensin-converting enzyme inhibitor or antagonists of angiotensin receptor blockers in the stable dose for the 4 months age 18 - 70 years stable clinical condition for the last 3 months GFR 25-60 ml / min / 1.73 m2 proteinuria 0.5-3 g / day  Exclusion Criteria:  diabetes mellitus other than t.2 have taken SGLT2 inhibitors in the last 4 weeks or have ever had an intolerance to SGLT2 inhibitors in the past acute kidney damage systolic blood pressure <90 mmHg Cancer acute inflammation liver failure heart failure> 2. NYHA grade pregnancy patients with impaired consciousness and testers with insufficient management in the past.