Inclusion Criteria:  Patient who has provided written and informed consent Adult patient  Patient undergoing cardiac surgery which is:  Scheduled With bypass surgery Of the following types: aortic valve surgery, mitral valve surgery, tricuspid valve surgery, atrial myxoma, coronary artery bypass surgery, aortic surgery, combined surgery  Exclusion Criteria:  Person not affiliated to national health insurance Person under legal protection (curatorship, guardianship) Person under court order Pregnant or breastfeeding woman Adult unable to express consent Patient already included once in the study Patient requiring emergency surgery within 24 hours Patients with hypersensitivity to local anesthetics or opiates or to any of the excipients in the products used Patients on antidepressants, neuroleptics such as non-selective MAOIs (iproniazid), selective A MAOI (moclobemide), selective B MAOI (selegiline) gabapentin (Neurontin®) Patients with an unprotected atrioventricular conduction disorder Patients with a prolonged QTc (> 450 ms) on preoperative ECG Patient with severe liver failure (PT< 30%) Patient suffering from respiratory failure (Long-term oxygen therapy patient except OSA) Patient with uncontrolled epilepsy Patient with preoperative cognitive dysfunction (MMS <24) Patient with intracranial hypertension Patient with chronic kidney failure (dialysis, creatinine > 200 μmol L-1) Patient with porphyria Patients treated with linezolid (Zyvoxid®) Patients with severe arterial hypotension (systolic BP<90 mmHg)