Inclusion Criteria:  Male or female, non-smoker and/or light smoker Have a diagnosis of stable renal impairment  Meet the following estimated glomerular filtration rate (eGFR) criteria during the screening period (based on 2 Screening visits) based on the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation:  Mild renal impairment: eGFR between 60 - 89 mL/min. Moderate renal impairment: eGFR ≥30 mL/min and <60 mL/min. Severe renal impairment: eGFR <30 mL/min, but not requiring hemodialysis. Normal renal function: eGFR ≥90 mL/min  Renal impairment participants:  Any form of renal impairment except acute nephritic syndrome (participants with history of previous nephritic syndrome but in remission can be included). Good general health commensurate with the population with chronic kidney disease (renal impairment). Stable concomitant drug regimen for the management of individual participant's medical conditions, so long as they are considered necessary for the welfare of the study participants (eg, standard therapy for underlying diseases), and are not contraindicated with study drug, and are unlikely to interfere with the PK of study drug.  Healthy participants with normal renal function:  No clinically relevant abnormalities identified by a detailed medical history, full physical examination, including temperature, blood pressure (BP) and pulse rate measurement, 12 lead ECG and clinical laboratory tests.  Demographically comparable to the group of participants with impaired renal function.  Each participant's body weight within ±15 kg of the mean body weight of renal impairment group. Each participant's age within ±10 years of the mean age of the renal impairment group.  Exclusion Criteria:  Positive test result for SARS-CoV-2 infection at the time of screening or Day -1. History of HIV infection, hepatitis B, or hepatitis C; positive testing at screening for HIV, HBsAg, HBcAb, or HCVAb. As an exception a positive HBsAb test due to Hepatitis B vaccination is allowed. Renal transplant recipients. Urinary incontinence without catheterization Any condition possibly affecting drug absorption (eg, prior bariatric surgery, gastrectomy, cholecystectomy, appendectomy). Participants who have been vaccinated with COVID-19 vaccines within the past 2 weeks of dosing, or are to be vaccinated with these vaccines at any time during the study. A positive urine drug test, for illicit drugs, at Screening aspartate aminotransferase (AST) or alanine aminotransferase (ALT) level >2 × upper limit of normal (ULN) Total bilirubin level ≥1.5 × ULN; participants with a history of Gilbert's syndrome may have direct bilirubin measured and would be eligible for this study provided the direct bilirubin level is≤ ULN. History of sensitivity reactions to ritonavir or any of the formulation components of PF 07321332 or ritonavir. Female participants of childbearing potential who are unwilling or unable to use highly effective methods of contraception as outlined in Section 5.3.4 for the duration of the study and for at least 28 days after the administration of investigational product, pregnant female participants, female participants planning to become pregnant during the duration of the study until 28 days after the administration of investigational product, breastfeeding female participants.  Renal impairment participants:  Participants requiring hemodialysis and/or peritoneal dialysis Participants with other clinically significant disease that may affect the safety of the participant or that may affect the PK of PF-07321332. Participants with any significant hepatic, cardiac, or pulmonary disease or participants who are clinically nephrotic.  Healthy participants with normal renal function:  Evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurological, or allergic disease (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at the time of dosing). Screening supine BP >140 mm Hg (systolic) or >90 mm Hg (diastolic), following at least 5 minutes of supine rest. If BP is >140 mm Hg (systolic) or >90 mm Hg (diastolic), the BP should be repeated 2 more times and the average of the 3 BP values should be used to determine the participant's eligibility.