Inclusion Criteria:  - HBsAg+  Persistent normal ALT 3-6m apart (<30 IU/ml in male and <20 IU/ml in female) HBV DNA < 2000 IU/ml LSM <8 Kpa  Exclusion Criteria:  Prior NUC/IFN exposure Renal dysfunction (Serum Creatinine >1.5 mg/dl) Known liver cirrhosis/ esophageal varices Any clinical decompensation (CD) Pre-existing hepatocellular carcinoma Pregnancy Healthcare workers (HCW) Post transplant, patients with advance malignancy or on chemotherapy Co-infections - Hepatitis C, Hepatitis D, Human immunodeficiency virus