Inclusion Criteria:  Healthy male aged from 20 to 51 at screening test Weight 50kg ~100kg BMI 18-27 Those who are fully understood, voluntarily decided to participate and signed prior to screening Those who are deemed suitable for participating in clinical trial due to lab tests, physical exam etc  Exclusion Criteria:  Those who have clinically significant liver, kidney, respiratory, endocrine, neurologic diseases or hematologic disease, mental diseases(mode disorder, obsessive compulsive disorder)