Inclusion Criteria:  BMD -4.0<T-score ≤-2.5 at either the lumbar spine or total hip or femoral neck All subjects must have at least one of following additional the risk factors:history of fracture, parental history of hip fracture, increased bone turnover rate at screening, low body weight, elderly (age≥65year)，current smoker Postmenopausal is defined as >2 years postmenopausal, which can be >2 years of spontaneous amenorrhea, or bilateral oophorectomy >2 years after surgery. If bilateral oophorectomy status is unknown, use follicle-stimulating hormone (FSH) levels > 40 mIU/mL to confirm surgical postmenopausal status.  Exclusion Criteria:  Bone/metabolic disease Hyperparathyroidism or hypoparathyroidism Thyroid condition: Hyperthyroidism or hypothyroidism Rheumatoid arthritis Malignant tumors Malabsorption syndrome Oral bisphosphonates