Inclusion Criteria:  patients with IBD diagnosed by colonoscopy and histopathology will classify the activity of the case to mild ,moderate and severe according to Mayo classification and have renal problems . Age (18 - 65 years)  Exclusion Criteria:  patients underage of 18 HCV or HBV patients renal patients diagnosed before diagnosis of IBD diabetic or hypertensive patients other autoimmune diseases such as Rheumatoid Arthritis, SLE. Malignancy