Inclusion Criteria:  Thai female and foreigner who can understand Thai language Age 15-49 years Diagnose as endometrioma sized more than 3 cm Underwent to surgery in next 13 weeks  Exclusion Criteria:  History of endometriosis Pregnancy woman Contraindication for desogestrel : History of thrombotic event, Autoimmune disease,gestational trophoblastic disease Ovarian endometrioma with complications : Ruptured, twisted Contraindications for NSAIDs : Peptic ulcer, thrombocytopenia, liver disease History of hormonal treatment for endometrioma : DMPA,OCP, GNRH agonist/antoginist