Inclusion Criteria:  BMI before surgery was ≥ 35,0 kg/m2 Patient has undergone a primary banded/non-banded Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) Gaining more than 5% weight after reaching plateau phase of lowest weight  Exclusion Criteria:  Anatomical or surgical abnormalities for which revisional surgery is indicated. Use of the following medication Monoamino-oxidase inbibitors (MAO), selective serotonin reuptake inhibitor (SSRI), Tricyclic antidepressants (TCA), haloperidol, risperidone, opioids, antiarrhythmics, betablockers, antiviral medication (HIV) Pregnancy or breastfeeding  Patients suffering from:  unregulated hypertension a tumour in the central nervous system severe liver failure end stage kidney failure Patients suffering from or with a history of insults  Patients with a history of:  bipolar disease bulimia or anorexia nervosa Patients withdrawing from alcohol or benzodiazepines Patients who are not able to understand the informed consent form and patient information.