Inclusion Criteria:  Histopathology proven diagnosis of squamous cell carcinoma of the oropharynx, localized to the tonsil and/or lateralized tongue-base ECOG Performance Status ≤2 Age ≥18 to 70 years Anesthetic fitness obtained for surgery under general anesthesia Resectable primary tumor with an anticipation of achieving resection free margins either by minimally invasive/open techniques Clinical stage III or IV, i.e. T1-T2 or T3-T4 with N0-N3. Nodal disease withextranodal extension on clinical examination/imaging may be included at the surgeon's discretion, if the nodal disease is deemed resectable by the operating surgeon HPV negative status determined by p16 status.  No distant metastases below the clavicles, based upon the following minimum diagnostic workup:  History/physical examination by the physician. Imaging of the head and neck (Contrast enhanced MRI for local workup and Chest CT/PET-CT for distant metastatic workup) Patients with no contraindications to Cisplatin chemotherapy and radiotherapy  Adequate organ function  Hematological- Hb> 10 g/L, ANC ≥ 1.5 x 109/L, platelets ≥ 100 x 109/L. Liver functions- bilirubin ≤ 2 x upper limit normal (ULN), AST/ALT/ ALP ≤ 2.5 x ULN, S. albumin ≥ 30 g/L. Renal function- Creatinine ≤ 1.5 ULN, Creatinine clearance > 50 mL/min. Women of child bearing age should have a negative pregnancy test at the time of randomization and should be willing to use adequate contraception during the treatment phase of the trial Patients who can be followed up and must be able to provide informed consent prior to study entry  Exclusion Criteria:  Prior head and neck malignancy Prior invasive malignancy, unless disease free for a minimum of 3 years Prior chemotherapy for a different cancer administered within 3 years prior to registration Patients who have received any neoadjuvant/ induction chemotherapy Prior radiotherapy to the region of the head and neck that would result in overlap of radiation therapy fields Unresectable primary or nodal disease involving the carotid vessels, prevertebral fascia or skull base Large soft palate involvement >1 cm Deep extension into larynx, pre-epiglottic space and deep invasion into extrinsic muscles of tongue Calculated GFR < 50 cc/min  Patients who have uncontrolled cardiac comorbidity  QTc prolongation (a value of >450 milliseconds) Ejection fraction below 50% Presence of regional wall akinesia Presence of previous episode of thrombosis or embolism or presence of a prothrombotic condition in last 1 year Presence of severe malnutrition as defined by body mass index of below 16kg per m2 or presence of weight loss of greater than 20% in last 6 months Severe active co-morbidities such as severe cardiac failure, severe pulmonary compromise, type 1or 2 diabetes mellitus (Hb1ac of > 8 mg/dl) severe and active infections or life expectancy less than 6 months Prior allergic reaction to cisplatin Radiographic evidence of retropharyngeal and/or level VI metastasis Patients on other investigational drugs within last 30 days