Inclusion Criteria:  People aged 45 to74 years who agree to participate in the study and who not meet any of the exclusion criteria  Exclusion Criteria:  Participants with a personal history of cardiovascular disease (ischaemic heart disease or stroke, peripheral arterial disease or Heart Failure) Participants with diabetes mellitus 1 or 2 Participants with a BMI> 40 kg / m2 Participants diagnosed renal failure in terminal stages (GFR <30 ml / min); Chronic intestinal inflammatory disease or acute inflammatory process in the past 3 months Oncology disease diagnosed in the last 5 years or with active treatment Participants who are in a terminal condition Consumption of antibiotics last 15 days