Inclusion Criteria:  Adult participants (≥ 25 to ≤ 85 years) Participants must be capable and willing to provide IRB-approved written informed consent Participants must be willing and able to attend all in-person study visits and complete all study assessments and questionnaires  Exclusion Criteria:  Autoimmune disorders Previous or currently undergoing chemotherapy, immunotherapy, or radiation therapy History of transplants, including solid organ or bone marrow transplants Presence of major active infection for which antibiotics and/or antivirals are prescribed within the last 14 days (chronic or acute, e.g., sepsis, HIV, pneumonia, active COVID infection) Dialysis Pregnant women