Inclusion Criteria:  Patient must be registered on the waiting list within The Nordic Network for Clinical Islet Transplantation Type 1 diabetes with diagnosed <40years of age and with>5 years of exogenous insulin use C peptide < 0.1 nmol/L at MMTT if no previous islet transplant Adequate previous treatment by an experienced diabetologist Patient must understand and be able to sign an informed consent  Exclusion Criteria:  Patient with a previous transplant other than islets Patient with an BMI>30 Patient with an need of more than 1U/kg of insulin per 24h Repeated abnormal liver function tests non stable retinopathy known abnormalities in coagulation known malignancies non stable heart conditions active infections serological proof of hepatitis B or C or HIV signs of portal hypertension patients that are pregnant, breast feeding or aim to become pregnant during the study period patients with a PRA > 20%, positive cross match or known DSA patients with conditions that the investigator would consider unsafe to combine with islet transplantation