Inclusion Criteria:  - Any adult healthy subject (with age 20-50 years old) not meeting any of the exclusion criteria listed below  Exclusion Criteria:  BMI < 18.5 kg/m2 or > 25 kg/m2 Any active pharmacological treatment Pregnancy or breastfeeding History of polyuria/polydipsia syndrome History of dysionia History of peptic disease History of gastrointestinal bleeding History of kidney disease History of heart disease History of asthma Known allergy to NSAIDs Any current acute medical condition