Inclusion Criteria:  Women or men greater than or equal to 18 years. Histologically confirmed invasive adenocarcinoma of the breast.  Clinical T0-4 N2-3 M0 at diagnosis (American Joint Committee on Cancer, 7th Edition)  Assessment for cN2 disease will be performed by clinical exam and imaging. Patients should have pathologic level 1 and/or 2 axillary lymph nodes which are fixed/matted on physical exam. Cross-sectional imaging will be used to identify advanced nodal disease involving the axilla, infraclavicular, supraclavicular, and internal mammary regions, cN3 disease. Patients must have biopsy proven involvement of the axillary lymph nodes. Receipt of standard multiagent chemotherapy +/- targeted therapy based on tumor subtype. Candidate for surgical management of breast cancer. Ability to understand and willingness to sign a written informed consent document.  Exclusion Criteria:  History of allergic reactions or hypersensitivity to radioactive lymph node mapping agents or blue dye. Pregnancy.