Inclusion Criteria:  Ability to provide written informed consent and comply with study assessments for the full duration of the study. Definite pathology signs of retinoblastoma, Stage I base on International Retinoblastoma Staging System. Received enucleation in the study eye. Monocular retinoblastoma.  Exclusion Criteria:  Any previous disease in the study eye. Previous participation in any studies of investigational drugs within 1 month preceding Day 0 (excluding vitamins and minerals). History of chemical intervention for retinoblastoma in the study eye.