Inclusion Criteria:  Histologically confirmed diagnosis of pTa metastatic tumors of the urogenital area; Patient who require repetitive transurethral resection; Expression of muc-1/wt-1 by the tumor; EGOC 0-3;  Exclusion Criteria:  any medical condition which can be associated with the high risk for the patient; pregnancy/lactation; chronic infections, including hepatitis B/C, tuberculosis, HIV