Inclusion Criteria:  T2D according to American Diabetes Association (ADA) criteria. Age ≥ 18 yr. HbA1c < 9.5%.). Presence of DPN based on Michigan Neuropathy Screening Instrument (combined questionnaire and a clinical examination of the response to vibration perception examination using a 128 Hz tuning fork and ankle reflexes), a validated, sensitive, and specific instrument for the diagnosis of DPN as reported. Quantitative sensory testing (QST) to hot and cold sensation evaluations (as measures of small-fiber neuropathy) will be also performed for DPN confirmation. Be willing and capable of providing a written consent form and willing and able to cooperate with the medical procedures for the study duration.  Exclusion Criteria:  History of any other causes of neuropathy (e.g. other neurological disorders, medications-induced, occupational history, active hepatitis C infection, exposure to toxins). Untreated hypothyroidism. Severe peripheral vascular, cardiac including pre-existing atrial fibrillation, pulmonary, or any other disorder affecting blood or tissue oxygenation. History of persistent macroalbuminuria (microalbuminuria up to 300 mg/24 hours is acceptable if calculated GFR is >60. Serum creatinine >1.4 for women and >1.5 for men or eGFR <50 [calculated using the Modification of Diet in Renal Disease (MDRD) equation]. Risk of bleeding disorder known to increase risk of bleeding or on medication for anticoagulation. Repeated use of aspirin other than 81 mg daily. Triglyceride > 400 mg/100ml. History of previous kidney, pancreas, liver, or cardiac transplantation. History of drug or alcohol abuse within 5 years, or current weekly alcohol consumption >10 units/week. Pregnancy or lactation or desire to become pregnant. Requiring long-term glucocorticoid therapy. Participation in an experimental medication trial within 3 months of starting the study. Undergoing therapy for malignant disease. History of gastrointestinal bleeding or active gastric ulcer. History of taking fish oil supplements in the last 6 months. History of fish or shellfish allergy. Presence of any condition that in the opinion of the investigators would make it unlikely for the subject to complete study. Known hypersensitivity to salsalate. Patients who have experienced asthma, hives, or other allergic-type reactions to aspirin or other NSAIDs are excluded from participation.