Inclusion Criteria:  Inclusion criteria for the LTBIDM arm:  18+ years Known DM type 2  Inclusion criteria for LTBI arm  18+ years LTBI positive No diagnosis with or known DM (1 and 2)  Exclusion Criteria (both arms) :  Previous treatment for TB or LTBI Pregnancy Type 1 DM Known immunosuppression such as: HIV, steroid treatment within 14 days before inclusion, daily NSAID treatment, ongoing chemotherapy, ongoing immunomodulating treatment or splenectomy Known contraindication to both study drugs Known active liver disease Known inflammatory or rheumatological diseases with immune activation such as IBD, RA, Psoriasis and Wegners granulomatosis Recent antibiotic treatment (>2 days) or severe infection within 14 days before enrollment Known active cancer