Inclusion Criteria:  Adult person, over 40 years of age, both sexes, resident in medium altitudes or 2,600 meters above sea level in the last 2 years. People with a diagnosis of COPD categorized in GOLD 1,2,3 and 4, with no record of respiratory crises in the last 3 months. People with a diagnosis of COPD categorized by lung function in GOLD 1,2,3 and 4 and by severity of symptoms in A, B and C, without the need for supplemental oxygen. People with a diagnosis of COPD settled and domiciled for a minimum time of 14 months at moderate altitudes or 2600 m.a.s.l. People who have read and signed informed consent and who have membership in a mandatory health plan.  Exclusion Criteria:  People with a medical diagnosis of anemia, liver disease, chronic kidney disease, rheumatological diseases or a history of gastrointestinal bleeding in the last 2 months. People with a diagnosis of COPD who have a history of kidney or liver transplantation. People with a diagnosis of COPD who present severity of symptoms and/or respiratory exacerbations categorized in D presenting an mMRC > 2 and CAT > 10 with >1 hospitalization requirements. People who are under pharmacological management with erythropoietin (EPO), antibiotics and / or steroids on a chronic basis. People with musculoskeletal injuries that limit the execution of the physical training program or that present medical restrictions for the execution of physical exercise. People with a diagnosis of COPD who record active smoking. People who are participating in research related to medical, pharmacological or physiotherapeutic intervention protocols.