Inclusion Criteria:  Subjects who have signed informed consent. Subjects were 20-80 years old and of either gender. Subjects showed good compliance, and the follow-up data was available for >5 years.  Exclusion Criteria:  Meet the 1999 World Health Organization (WHO) diagnostic criteria for T1DM、T2DM; Renal diseases caused by other causes, including primary and secondary; All kinds of acute infections; The expected life expectancy (life expectancy or related diseases) was less than 5 years according to the researcher's judgment. Drug users or drug abusers; Sexually transmitted diseases such as viral hepatitis, AIDS and syphilis, and infectious diseases such as tuberculosis are in an active period; Any situation judged by the researcher that affects enrollment.