Inclusion Criteria:  Documented diagnosis of advanced malignant disease Advanced malignant disease without any available standard of care treatment option Live expectancy > 3 month Ability to understand and voluntarily sign an informed consent form. Ability to adhere to the visit schedule and other protocol requirements Eastern Cooperative Oncology Group (ECOG) performance status score of ≤ 2.  Exclusion Criteria:  Pregnant or lactating females. Treatment regimens inducing severe T cell deficiencies Treatment-related side effect from prior cancer treatment > CTC grade 2 (CTCAE V5.0) Participation in any clinical study or having taken any investigational therapy, which would interfere with the studys primary and secondary end points within 2 weeks prior to Ab treatment.