Inclusion Criteria:  The participant is capable of understanding the contents of the investigation, recording his/her own symptoms in the health observation diary, and has obtained written consent to participate in the investigation from the vaccinee himself/herself (If minor, parent or legal guardian). The participant has an underlying disease at the time of this drug vaccination that is considered to pose a high risk of aggravation of COVID-19.  Exclusion Criteria:  1. The subject has any contraindication to this drug.