Inclusion Criteria:  Poorly treated FH, defined as LDL-C >5.5 mmol/L. Age, >18 and <65 years of age. A age matched control-group.  Exclusion Criteria:  Additional cardiovascular comorbidities such as diabetes mellitus, coronary artery disease, or kidney failure. Any condition which interfere with the outcome recording for example atrial fibrillation. Unwillingness to participate. Concurrently participating in another interventional trial.