Inclusion Criteria:  Patients with advanced cancers that failed to current available therapies; Life expectancy >12 weeks; Adequate heart, lung, liver, kidney functions; Available for tumor biopsy or cancerous effusions; Informed consent explained to, understood by and signed by patient/guardian. Patient/guardian given copy of informed consent.  Exclusion Criteria:  Had accepted gene therapy before; Severe virus infection such as HBV, HCV, HIV, et al; Known HIV positivity; Active infectious disease related to bacteria, virus, fungi, et al; Other severe diseases that the investigators consider not appropriate; Pregnant or lactating women; Systemic steroid treatment (greater than or equal to 0.5 mg prednisone equivalent/kg/day); Other conditions that the investigators consider not appropriate.