Inclusion Criteria:  Age 18 to 65 years At least one sputum smear and or CBNAAT test should be positive for tubercle bacilli Female participants of childbearing potential must have a negative urine pregnancy test at screening. Those who have not undergone permanent sterilisation - tubal ligation or spouse with vasectomy must agree for use of contraceptive measures for birth control - vaginal diaphragm, intrauterine device, condom until treatment completion. Willing to follow the trial procedures Willing to give written informed consent Residing within the study TU  Exclusion Criteria:  Body weight less than 30 kg Previous anti-TB treatment, if any, should not exceed one month in the past 2 years and more than 7 days in the preceding one month Multidrug resistant TB (MDR-TB) Resistance to isoniazid or rifampicin or quinolone as evidenced by Cartridge based Nucleic acid Amplification test (CBNAAT) and Line probe Assay (LPA) test Associated extra-pulmonary TB except TB superficial lymphadenitis Hepatic or renal disease as evidenced by clinical or biochemical abnormalities- ALT/AST> 2.5 times ULN or Total bilirubin >1.2 mg/dl, Serum Creatinine >1.2 mg/dl, Blood Urea >43 mg/dl. QTcF> 450 ms or bundle branch block or heart block on ECG Psychiatric illness Seizure disorder Pregnancy or lactation Those seriously ill as defined by a score of <50 on Karnofsky scale (Annexure 1)