Inclusion Criteria:  Adult subject (≥ 18 years old) Patient having consented to the research  Group 1:  Patient with cancer who was treated with immunotherapy Appearance of CT lung abnormalities during immunotherapy, not related to cancer With high suspicion of infiltrative lung disease: Pneumopathy (CTCAE version 5 classification). Patients requiring bronchial fibroscopy with BAL  Groups 2:  Patient with lung cancer with peripheral tumor Requires surgical pulmonary lobectomy in the operating room  Exclusion Criteria:  Patient treated or having been treated in the last 2 months with corticosteroid therapy Patient treated with immunosuppressant and/or cyclophosphamide, and/or Anti-TNF α in the last 12 months Absence of consent Patient under curatorship, guardianship or safeguard of justice Pregnant woman Group 1: Patient with respiratory failure  Groups 2:  Patient with lung cancer with proximal or endobronchial tumor Patients requiring bilobectomy or pneumonectomy Patient who has been treated with immunotherapy