Inclusion Criteria:  In good general health at the screening visit, as determined by the investigator from medical history. Subjective complaints of poor near vision that impacts activities of daily living, as defined by at least a moderate impact (score > = 3) on at least 1 question on NEI VFQ-25 Questions 5 to 7 in the main questionnaire or near vision subscale, Questions A3 to A5 in the Appendix of Optional Additional Questions, at the screening visit. Note: Please advise the participant that for this questionnaire they are to interpret the instructions as referring to glasses or contacts they need for seeing objects at a distance (if required), not their reading glasses or bifocals. Photopic, high-contrast, best distance correction in the range of spherical -4.00 D to +1.00 D inclusively and cylinder < = + -2.00 D with photopic at the screening visit and photopic, high-contrast BCDVA of 20/25 or better OD and OS at the screening visit. Photopic, high-contrast HDVA of 20/32 or better OU at screening as well as before and 1 hour after dosing at both driving tests. Only monofocal correction (either spectacles or contact lenses) is allowed for the driving tests. If the participant does not have monofocal correction of 20/32 or better OU, the study site will provide monofocal spectacles. Mesopic, high-contrast DCNVA of 20/40 to 20/100 OD and OS at screening Photopic, high-contrast near visual acuity correctable to 20/40 or better in each eye at the screening visit. Mesopic pupil diameter < 8.0 mm in both eyes at the screening visit.  Exclusion Criteria:  History of cataract surgery, phakic intraocular lens surgery, corneal inlay surgery, radial keratotomy, or any intraocular surgery. Use of any topical ophthalmic medications, including artificial tears other than the study medications during the study. Use of temporary or permanent punctal plugs or history of punctal cautery in one or both eyes. Corneal abnormalities in either eye that are likely to interfere with visual acuity. Narrow iridocomeal angles, history of angle-closure glaucoma, or previous iridotomy. Diagnosis of any type of glaucoma or ocular hypertension. Females who are pregnant, nursing, or planning a pregnancy during the study. Uncontrolled systemic disease. Severe dry eye disease. History of iris trauma. Lens opacity in either eye that is determined to cause significant disturbance of the central visual axis on screening biomicroscopy.