Inclusion Criteria:  BMI 18.5 - 25.0 kg/m2 Untrained in resistance exercise No known chronic disease or current acute illness No current or recent (past 3 months) musculoskeletal injury No frequent use (2x per week for past month) of non-steroidal anti-inflammatory drugs, anti-oxidant supplements, polyunsaturated omega-3 fatty acids (and other substances that may alleviate muscle damage) and compliant to abstain from use during experimental period No recent or current engagement in massage or cryotherapy and compliant to abstain from use during experimental period Females will be eumenorrheic (regular menstrual cycle) >12 months Absence of pregnancy and breast-feeding  Exclusion Criteria:  Underweight Overweight/obese Resistance trained Current or recent injury Pregnancy or breast-feeding Unwilling to provide blood samples, perform resistance exercise, or abstain from use of NSAID's and other substances (stated above) Unwilling to abstain from other forms of exercise during the experimental period