Inclusion Criteria:  Clinical Inclusion criteria  Age ≥18 years Pre-stroke mRS 0~2 Acute ischemic stroke (NIHSS score 6-30) Time-last-known-well to puncture ≤ 8 hours Informed consent  Baseline Imaging Inclusion Criteria  1.Anterior circulation stroke: NECT or DWI ASPECTS ≥ 6; Posterior circulation stroke: CTA-SI or DWI pc-ASPECTS ≥ 6 and Pons-Midbrain Index (PMI) < 3  Angiographic Inclusion Criteria  Acute ischemic stroke caused by LVO, including intracranial internal cerebral artery (ICA)，M1 of the middle cerebral artery (MCA)，V4 of vertebral artery（VA) or basilar artery (BA) Failed recanalization (eTICI 0-2a) after 1-3 attempts of thrombectomy with stent retriever and/or contact aspiration Microcatheter can pass through the occluded segment before randomization Occluded artery amenable to angioplasty by judgement of the treating neurointerventionalist  Exclusion Criteria:  Any sign of intracranial hemorrhage on brain imaging prior to thrombectomy CT or MRI evidence of mass effect or intracranial tumor Any sign of intracranial vessel perforation during mechanical thrombectomy prior to randomization Contraindication of anti-platelet treatment History of contraindication for contrast medium Current use of oral anticoagulants (e.g. INR > 1.7 for Vitamin K antagonists) Current pregnant or breast-feeding Known to have dementia or psychiatric disease unable to complete neurological assessment and follow-up Life expectancy is less than 3 months Enrolled in another drug or device trial or expected to participate in another drug or device treatment trial within the following 3 months. Any other condition (in the opinion of the site investigator) that inappropriate to participate this study