Inclusion Criteria:  Men and women aged above 16 years Clinical diagnosis of MS as per revised McDonald Criteria 2017 Existing susceptibility-weighted brain MRI scan Able to provide blood samples  Exclusion Criteria:  Unwilling or unable to comply with the requirements of this protocol including the presence of any condition (physical, mental or social) that, in the opinion of the PI, is likely to affect the participants ability to comply with the study protocol. Unable to provide informed consent.