Inclusion Criteria:  Male or Female. Age >18 years old at the beginning of the study. Diagnosis of type 2 diabetes prior to the start of the study. Therapeutic failure to a dual treatment with SGLT2 / Metformin, Biguanide / Sulfonylurea, Sulfonylurea / iDPP4, Biguanide / iDPP4. HbA1c ≥ 7.5% and ≤ 11% during screening tests. Women of childbearing potential using a contraceptive method (barrier, oral hormonal, injectable, subdermal) or naturally or surgically sterile in menopause. Subject agree to participate in the study and give informed consent in writing.  Exclusion Criteria:  The drug is contraindicated for medical reasons. History of Type 1 Diabetes Mellitus. History of metabolic complications such as ketoacidosis or nonketotic hyperosmolar state. History of gastric bariatric surgery or gastric band in the last year. History of drug or alcohol abuse in the past year. Body Mass Index <20 kg/m2 and >40 kg/m2. Acute or severe renal dysfunction (glomerular filtration <30 ml / min / 1.72 m2). History of chronic liver disease or ALT and / or AST ≥3 times the normal upper limit and / or Total Bilirubin> 2.5 times the upper limit of normal, or GGT ≥3 times the upper limit of normal. Pregnant and / or lactating women. The patient is participating in another clinical study involving an investigational treatment or participated in one in the previous 4 weeks. At medical criteria, a disease that affects the prognosis and prevents outpatient management, for example, but not restricted to: end-stage cancer, kidney, heart, respiratory or liver failure, mental illness, with scheduled surgical or hospital procedures. Be a patient with a working relationship with the main researcher or the research center or deprived of liberty.