Inclusion Criteria:  The subject or his/her guardian and/or impartial witness voluntarily signed the written informed consent form（ICF）. Aged 18 to 80 Years old (Female or male subjects to the date of signing the informed consent form). Subjects with solid tumor confirmed by histological or cytological examination. At least one documented bone metastasis confirmed by computed tomography[CT], magnetic resonance imaging[MRI]) or pathology (bone biopsy). Eastern Cooperative Oncology Group（ECOG）performance status≤2. Adequate organ function at baseline.  Exclusion Criteria:  Prior treatment with denosumab or other RANKL-targeted therapeutic drugs. Subjects who previously received any bone-modifying agents (including intravenous or oral bisphosphonates, etc.) for advanced tumor disease. Orthopedic surgery or bone-related radiation therapy within 1 month prior to first dose. Bone radioisotope therapy within 6 months prior to first dose, or planned radiation therapy or surgery for bone during the study. Past or ongoing osteomyelitis or osteonecrosis of the jaws （ONJ）, an active dental or jaw condition requiring oral surgery, non-healed dental or oral surgery, or any planned invasive dental procedure during the study period. Primary central nervous system malignancy. Subjects with central nervous system metastases who have failed local therapy. Subjects with asymptomatic brain metastases or clinically stable brain metastases who do not require steroids and other therapy for brain metastases for ≥ 28 days may be enrolled.