Inclusion Criteria:  Patients must have a solid tumor with a pathogenic inactivating TSC1 or TSC2 alteration. Genetic alterations should be identified in tumor tissue using NGS (ie, not by liquid biopsy alone).  • Patients will be enrolled after the central evaluation of NGS report confirms eligibility.  Patients must provide baseline tumor tissue samples. Patients must have solid tumors that are metastatic or locally advanced where surgical resection is not an option or likely to result in severe morbidity. Patients must have received all standard therapies appropriate for their tumor type and stage of disease or, in the opinion of the Investigator, the patient would be unlikely to tolerate or derive clinically meaningful benefit from appropriate standard of care therapy, or the patient has no satisfactory alternative treatments. Patients must have 1 or more measurable target lesions by computed tomography (CT) scan or magnetic resonance imaging (MRI) (RECIST v1.1 or RANO, as applicable for their tumor type). Age: 12 years or older Eastern Cooperative Oncology Group (ECOG) performance status 0, 1, or 2 or Karnofsky Performance Status (KPS) ≥70 or Lansky play-performance scale for pediatric patients ≥70  Adequate liver function:  Total bilirubin ≤1.5 × upper limit of normal (ULN) Aspartate aminotransferase (AST) ≤2.5 × ULN (≤5 × ULN if attributable to liver metastases)  Adequate renal function:  a. Creatinine clearance ≥50 mL/min, Cockcroft-Gault CCr = ((140-age) x weight[kg]) / (72 x SCr[mL/min]) x 0.85, if female  Adequate hematologic parameters:  Absolute neutrophil count (ANC) ≥1.0 × 109/L (growth factor support allowed) Platelet count ≥100,000/mm3 (100 × 109/L) (transfusion and/or growth factor support allowed) Hemoglobin ≥8.0 g/dL (transfusion and/or growth factor support allowed) Fasting serum triglyceride must be ≤300 mg/dL; fasting serum cholesterol must be ≤350 mg/dL. Minimum of 4 weeks since any major surgery, completion of radiation, or completion of all prior systemic anticancer therapy, or at least 5 half-lives if the prior therapy is a single agent small-molecule therapeutic, and adequately recovered from the acute toxicities of any prior therapy, including neuropathy to Grade ≤1.  Male or non-pregnant and non-breastfeeding female:  Females of child-bearing potential must agree to use effective contraception or abstinence without interruption from 28 days prior to starting investigational product (IP) throughout 3 months after last dose of IP and have a negative serum pregnancy test (beta human chorionic gonadotropin, β-hCG) result at screening and agree to ongoing pregnancy testing during the course of the study, and after the end of study treatment. A second form of birth control is required even if she has had a tubal ligation. Male patients must practice abstinence or agree to use a condom during sexual contact with a pregnant female or a female of childbearing potential while participating in the study and throughout 3 months after last dose of IP. A second form of birth control is required even if he has undergone a successful vasectomy. The patient or the patient's parent(s) or legal guardian(s) understand(s) and sign(s) the informed consent. Willingness and ability to comply with scheduled visits, laboratory tests, and other study procedures.  Exclusion Criteria:  Prior treatment with an mTOR inhibitor, including ABI-009. Recent infection requiring systemic (oral or IV) anti-infective treatment, either ongoing or completed ≤14 days prior to enrollment (except for uncomplicated urinary tract infection or upper respiratory tract infection).  Patients who have any severe and/or uncontrolled medical or psychiatric conditions or other conditions that could affect their participation including:  Patients with meningeal carcinomatosis, leptomeningeal carcinomatosis, spinal cord compression, untreated brain metastases or symptomatic or unstable brain metastases. Note: Patients with stable brain metastases (defined as asymptomatic or no requirement for high-dose [defined as dexamethasone 10 mg daily or higher] or increasing dose of systemic corticosteroids) and without imminent need of radiation therapy are eligible. If applicable, patients must have completed brain radiation therapy and recovered adequately from any associated toxicity and/or complications prior to eligibility assessment. For patients who have received prior radiation therapy, post-treatment MRI scan should show no increase in brain lesion size/volume. Unstable angina pectoris, symptomatic congestive heart failure (New York Heart Association, NYHA class III or IV), myocardial infarction ≤6 months prior to first study treatment, serious uncontrolled cardiac arrhythmia or any other clinically significant cardiac disease. Pre-existing severely impaired lung function. If a patient has a pre-existing pulmonary condition, eligible patients should have a spirometry and diffusing capacity for carbon monoxide (DLCO) that is >50% of the normal predicted value and/or O2 saturation that is >88% at rest on room air (Note: spirometry and pulmonary function tests [PFTs] not required to be performed unless clinically indicated). Nonmalignant medical illnesses that are uncontrolled or whose control may be jeopardized by the treatment with the study therapy. Note, controlled non-melanoma skin cancers, carcinoma in situ of the cervix, resected incidental prostate cancer, or other adequately treated carcinoma-in-situ may be eligible, after documented discussion with Aadi / the medical monitor. Uncontrolled hypertension (systolic blood pressure ≥160 mm Hg and/or diastolic blood pressure ≥100 mm Hg). Patients with history of interstitial lung disease and/or pneumonitis, or pulmonary hypertension. Individuals with known human immunodeficiency virus (HIV) infection are excluded from this study as combination antiretroviral therapy could potentially result in significant pharmacokinetic interactions. In addition, these individuals are at increased risk of serious infections due to the immunosuppressive effects of mTOR inhibition. Active Hepatitis B or Hepatitis C, with detectable viral load. Note: A detailed assessment of Hepatitis B/C medical history and risk factors must be done at screening for all patients. Regarding concomitant medications with significant CYP3A4 and P-gp interactions, discontinuation of strong inhibitors (eg, ketoconazole, itraconazole, voriconazole, erythromycin, clarithromycin, telithromycin, and others), strong inducers (eg, rifampin, rifabutin), and known CYP3A4 substrates with a narrow therapeutic window (eg, fentanyl, alfentanil, astemizole, cisapride, dihydroergotamine, pimozide, quinidine, or terfenadine) is required at least 5 half lives prior to receiving the first dose of ABI-009, whichever is longer.