Inclusion Criteria:  Patient age > 60 years at screening Patient willing to participate in the study and can provide inform consent Patient have residual kidney function ≤ 90 ml/min/1.73m2 by CKD-EPI equation  Exclusion Criteria:  Patient active smoking Patient have Charlson comorbidity index > ..... Patient active cancer Patient contraindications for blood collection Patients with a history of hypersensitivity to cimetidine or amino acid IV solution