Inclusion Criteria:  Female / male aged> 45 years Diagnosis of knee ostheoarthritis after physical examination and imaging (direct radiography) Those whose symptoms persist> 6 months Radiological staging of osteoarthritis according to the Kellgren-Lawrence scale Grade 2 and 3 Participation in the study voluntarily and regularly  Exclusion Criteria:  History of previous knee surgery Patients with inflammatory arthritis (Rheumatoid arthritis, psoriatic arthritis, gouty arthritis as) Patients with neuropathic pain Those with pain reflected from the waist or hip History of tumor, infectious, psychiatric illness, bleeding diathesis Trauma history within the last 6 months Hyaluronic acid or steroid injection in the last 3 months Those with systemic diseases such as diabetes, rheumatoid arthritis, hepatitis, coagulopathy Those with malignant hypertension Those with G6PDH (Glucose 6-Phosphate Dehydrogenase) deficiency Those with Graves' disease Those with cerebrovascular event disease in which bleeding continues actively