Inclusion Criteria:  Age of women <43 years at the time of ovarian stimulation for IVF PGT-A indicated for advanced maternal age (>40 years), recurrent miscarriage (>=2 or 3 consecutive miscarriage and repeated implantation failure (>=4 embryos replaced or >=2 blastocysts replaced without success)  Exclusion Criteria:  Presence of a functional ovarian cyst with E2>100 pg/mL use of donor eggs/sperm, Presence of hydrosalpinx or endometrial polyp which is not surgically treated moderate or severe endometriosis