Inclusion Criteria for both Part 1 and Part 2 of the trial:  Patient must be 18 years of age inclusive or above, at the time of signing the informed consent. Confirmed tumor cell CD1d positivity/expression. Patients with documented diagnosis of CLL, MM, or AML who have failed to respond to or who have relapsed after prior therapy and are not amenable to standard treatments or for whom no standard treatments are available.  Males or non-pregnant, non-breastfeeding females who are:  Surgically sterile Female of childbearing potential with a negative pregnancy test prior to first dosing and compliant with a highly effective contraceptive regimen from signing of the informed consent form (ICF) through 90 days after the last Investigational Medicinal Product (IMP) administration. Female, postmenopausal defined as continuous amenorrhea for at least 12 consecutive months without an alternative medical cause and a serum follicle-stimulating hormone (FSH) measurement of > 40 IU/L). Male, compliant with an effective contraceptive regimen from signing of the ICF through 90 days after the last IMP administration. Male, refraining from donating sperm following from signing of the ICF through 90 days after the last IMP administration. Predicted life-expectancy of ≥ 3 months. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. Adequate renal function ((estimated glomerular filtration rate (eGFR) per local laboratory> 40 mL/min/1.73m2)), hepatic function [(total bilirubin ≤ 2 times upper limit of normal (ULN); aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 3.0 times ULN] and hematological function (neutrophils ≥ 1 x109/L; platelet count ≥ 75x109/L Capable of giving signed and dated informed consent prior to initiation of any trial-related procedure that is not considered Standard of Care which includes compliance with the requirements and restrictions listed in the ICF and in the protocol.  Exclusion Criteria:  Prior allogeneic bone marrow transplant as long as the patient still has active acute or chronic graft versus host disease requiring >10 mg prednisone or equivalent corticosteroids. Concomitant malignancies except carcinoma in situ, basal or squamous cell skin carcinoma. Patients who had no evidence of disease from another primary cancer for 2 or more years are allowed to participate in the trial. Localized non-metastatic prostate cancer, not requiring systemic treatment, and for which no local treatment is planned, is allowed. Uncontrolled or severe intercurrent medical condition. Known uncontrolled central nervous system involvement. A significant history of renal, neurologic, psychiatric, pulmonary, endocrinologic, metabolic, immunologic, cardiovascular, or hepatic disease that in the opinion of the investigator would adversely affect his/her participating in this trial. Unstable cardiovascular function defined as: (a) symptomatic ischemia, or (b) uncontrolled clinically significant conduction abnormalities (i.e., ventricular tachycardia on antiarrhythmic agents are excluded; 1st degree atrioventricular block or asymptomatic left anterior fascicular block/right bundle branch block (left anterior fascicular block /right bundle branch block) will not be excluded), or (c) congestive heart failure New York Heart Association Class ≥ 3, or (d) myocardial infarction within 3 months. Previous treatment with radiotherapy, immunotherapy, or chemotherapy in the 2 weeks prior to initial IMP administration. Previous treatment with biological therapy or with an investigational product in the 4 weeks prior to initial IMP administration. Previous treatment of any systemic immunosuppressant within 2 weeks prior to initial IMP administration, with the exception of systemic corticosteroid use up to oral dose of 10 mg prednisolone daily (or equivalent for other steroids). Previous treatment with live or live attenuated vaccines within 2 weeks prior to initial IMP administration. Other (new) types of vaccines need to be evaluated as to their mode of action. Known non-CLL/MM/AML related pre-existing clinically relevant immunodeficiency disorders. Positive serological testing for human immunodeficiency virus (HIV) antibody, hepatitis B surface antigen [HBsAg] and hepatitis B core antibody (anti-HBc) negative, and hepatitis C virus antibody. Patients who are positive for anti-HBc or hepatitis C antibody may be included if they have a negative Polymerase Chain Reaction (PCR) within 6 weeks prior to initial IMP administration. Those who are PCR positive will be excluded. Known allergies, hypersensitivity, or intolerance to the excipients of the IMP. Major surgery within 4 weeks of initial IMP administration or planned surgery during the time the patient is expected to participate in the trial. Known ongoing drug and alcohol abuse in the opinion of the investigator.