Inclusion Criteria:  Be willing and able to provide written consent. Over 18 years of age. Undergo and satisfy MRI Safety Screening Patient volunteers must be under the care of a clinical oncologist at The Christie NHS Foundation Trust and be planned to receive radiotherapy to the target site to be imaged.  Patient volunteers must be able to give blood and/or urine sample as required through the treatment period.  Non-patient (healthy) volunteers must have no known or suspected significant medical condition.  Exclusion Criteria:  The following apply to both patients and healthy volunteers:  Any conditions that would be a contra-indication to MRI including:  Failure to satisfy MRI Safety Screening Form Implanted pacemakers and/or pacing wires Cochlear implants Programmable hydrocephalus shunts Ferromagnetic implants Unable to tolerate MR scans Known HIV or active HepB or C Pregnancy Healthy volunteers must not be a member of the study team.