Inclusion Criteria:  Paediatric patients (male and female), aged 3- ≤ 12 months Scheduled general anaesthesia with sevoflurane and opioid. Induction with propofol is optional The legally acceptable representative for the study participant provides written informed consent/assent for the trial  Exclusion Criteria:  ASA >2 Cardiac, neuro and trauma surgery Ex-premature (<37 weeks) • Premedication with clonidine Intubated prior to scheduled anaesthesia or is expected to require intubation after the procedure Critical illness incl. hemodynamic instability (inotropic drugs needed) Bleeding requiring transfusion prior to scheduled anaesthesia Planned for a postoperative nurse-controlled analgesia pump including a continuous infusion of opioid Malignant disease Cardiac disease incl. arrhythmia Chronic lung disease that may influence study results or study participation in the opinion of the Investigator or may comprise safety and well-being of the patient Mental retardation Neurological disease including symptoms similar to emergence agitation Has or is suspected of having a family or personal history of malignant hyperthermia Has or is suspected of having an allergy to study treatment or its excipients Any condition that can in opinion of the Investigator, deteriorate safety and well-being of the patients or interfere with pharmacokinetic data Positive Covid-19 test or clinical suspicion of Covid-19 (according to current local guidelines)