Inclusion Criteria:  Patients diagnosed with major depressive disorder of either gender within the age group of 18-65 years Patients with MADRS score ≥ 7 and ≤ 34 (patients having mild to moderate MDD). Patients who are on a stable dose of Sertraline 50 mg or any other Selective Serotonin Reuptake Inhibitor (SSRI) therapy in equivalent dose. Patients who have given written informed consent.  Exclusion Criteria:  Patients who have been treated with Electro Convulsive Therapy (ECT) recently. History of epilepsy, or other major neurological or medical disorders, head trauma. Patients with a history of Bipolar Depression (BPD). Patients with schizophrenia or other psychotic disorder. Patients with suicidal thoughts or risk. Patients with cognitive impairment. Initiating or stopping formal psychotherapy within six weeks before enrolment. Patients with comorbidities like any malignancies, hepatic, renal, cardiovascular, neurological or endocrinal, respiratory dysfunction. Substance abuse history of psychoactive agents. Pregnant and lactating mothers.