Inclusion Criteria:  measurable metastatic uveal melanoma. No concomitant therapy. Prior PD1 or tebendafesp allowed. Performance status 0-1. No active Hepatitis B. No known HIV infection. WBC>2000, ANC>1500, Hgb >8. Creatinine < 3 x ULN. AST & ALT < 2.5 x ULN Bilirubin < 2 x ULN. Albumin >2.9  Exclusion Criteria:  Liver tumor volume > 50%. Active CNS metastases. Pregnancy. Prior therapy with ipilimumab or other CTLA-4 inhibitor. Certain autoimmune diseases. Previous liver embolization or radiation. Use of systemic steroids