Inclusion Criteria:  Male and female ≥ 18 years of age Must have a suspected or biopsy-proven glioma (World Health Organization grade II or IV), new or recurrent Indication for craniotomy for removal of a suspected or recurrent brain tumor Karnofsky Performance Scale ≥ 60% Willing and able to provide informed consent or have surrogate consent by legally authorized representative  Exclusion Criteria:  Male and female < 18 years of age Porphyria, hypersensitivity to porphyrins Renal insufficiency as defined by a creatinine > 2.0 mg/dL Hepatic insufficiency as diagnosed in preoperative medical clearance evaluation Females of childbearing potential with a positive pregnancy test Nursing women Unwilling or unable to provide informed consent