Inclusion Criteria:  Patients with chronic liver disease up to progressive cirrhosis (e.g. ethyltoxic, Viral hepatitis, fatty liver, autoimmune hepatitis, colorectal liver metastases, HCC).  Patients with elevated liver values undergoing elective abdominal surgery.  As comparison groups patients with acute hepatitis (e.g. viral or autoimmune genesis) and patients without liver disease.  Exclusion Criteria:  Age under 18