Inclusion Criteria:- healthy subjects (all 3 Parts)  evidence of steatosis on FibroScan (Part 2 only) BMI 17.5 to 30.5 kg/m2 (Part 1, Part 3) BMI 17.5 to 35.4 kg/m2 (Part 2) Exclusion Criteria:- evidence of clinically significant disease subjects on chronic medications clinically significant, abnormal laboratory results, vital signs, or cardiac conduction abnormalities contraindication to MRI (Part 2, only)