Inclusion Criteria:  Ability to understand and the willingness to sign a written informed consent document Have pathology proven peritoneal carcinomatosis (PC) due to colorectal, ovarian, gastric, pancreatic, appendiceal cancer or mesothelioma No other standard treatment options are available Measurable intraperitoneal disease by RECIST v1.1 criteria on imaging studies 18 to 75 years of age Have an ECOG performance of 0 to 2 Have adequate organ and bone marrow functions as indicated by: Leukocytes ≥ 3000/mcL Absolute neutrophil count ≥ 1500/mcL Platelets ≥ 100000/mcL Total bilirubin within normal institutional limits AST (SGOT) < 3 x institutional upper limit of normal ALT (SPGT) < 3 x institutional upper limit of normal Medically fit for surgery. Defined as: Patients who are able to undergo general anesthesia for abdominal surgery and have a metabolic equivalent (METs) ≥ 4  Have adequate contraception, as follows:  Women of child-bearing potential and men with partners of child-bearing potential must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and for 10 months beyond the last dose of TPM. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately A woman of child-bearing potential is any female (regardless of sexual orientation, having undergone a tubal ligation, or remaining celibate by choice) who meets the following criteria: has not undergone a hysterectomy or bilateral oophorectomy; or  has not been naturally postmenopausal for at least 12 consecutive months (i.e., has had menses at any time in the preceding 12 consecutive months)  c. Men with partners of child bearing potential must use barrier contraceptive  d. Men of child-bearing potential must not donate sperm while on this study and for 7 months after the last dose of TPM  Acceptable forms of birth control are listed below:  One Barrier method (cervical cap with spermicide plus male condom; diaphragm with spermicide plus male condom) OR Hormonal method (oral contraceptives, implants, or injections) or an intrauterine device (e.g., Copper-T)  Exclusion Criteria:  Presence of mucinous ascites Evidence of extra-peritoneal metastases Current or expected use of other investigational agents Received systemic chemotherapy or radiotherapy within 3 weeks prior to study enrollment or not recovering from adverse events (e.g., recovery to ≤ Grade 1) Abdominal cavity deemed not accessible by treating surgeon due to prior abdominal surgery History of allergic reactions to paclitaxel, PLG co-polymer, mannitol, or polysorbate 80 Uncontrolled intercurrent illness Currently active second malignancy other than non-melanoma skin cancer Pregnancy, nursing, or plans to become pregnant for the duration of study participation including 10 months beyond the last dose of TPM Grade 2 or higher peripheral neuropathy CrCL ≤ 4 mL/min Actively treated for other malignancy Patients with HIV or Hepatitis B/C requiring the use of ART agents