Inclusion Criteria:  The subject's parent or legal guardian must provide signed and dated informed consent (parent permission form). The subject's parent or legal guardian of the subject must be willing and able to comply with study requirements. The subject is a 10-20 months at the time of enrollment. The subject must be in good general health as evidenced by parent report. The subject will have at least 1 erupted tooth that is either sound or has only a d1 (white spots) lesion.  Exclusion Criteria:  Previous treatment with fluoride varnish Known allergy to iodine Diagnosis of thyroid disease Chronic, prophylactic use of antibiotics Treatment with another investigational drug or intervention within 30 days preceding the Baseline Visit. Visible cavities (d2-4) Presence of intraoral pathology that would make assessment of post treatment soft tissue ulcerations or inflammation impossible (child could be enrolled if problem is treated and lesions cleared) Parent anticipates the child will move from Pohnpei during the next 2 years.