Inclusion Criteria:  Diagnosis of essential tremor in accordance with modified Tremor Investigation Group (TRIG) criteria as described in the protocol. The Essential Tremor Rating Assessment Scale (TETRAS) upper limit (UL) score (0-4 scale) > 2 in the dominant limb on at least one of the 3 maneuvers. TETRAS Archimedes spiral task score > 2 in the dominant limb. TREDS-Revised Scale (1-4 scale) unilateral score of >= 3 for the Tremor Disability Scale (TREDS) on any of the 7 unilateral items; no more than a single item score of 1 among the 7 unilateral items in the dominant limb. TETRAS activities of daily living (ADL) (0-4 scale) minimum score of >= 3 on any of the 5 unilateral items; no more than a single item score of <=1 among the 5 unilateral items in the dominant limb.  Exclusion Criteria:  Any uncontrolled clinically significant medical condition other than the one under study. Any medical condition that may put the participant at increased risk with exposure to BOTOX Purified Neurotoxin Complex.