Inclusion Criteria:  no sign of malnutrition (defined as one of the following unintentional weight loss by at least 10% or body mass index (BMI) < 18), good general status (Karnofsky Performance Index > 80, Eastern Cooperative Oncology Group (ECOG) grade 0 or 1); no confirmed neoplastic dissemination no severe concomitant disease (heart, lung, kidney, liver failure, chronic obstructive pulmonary disease [COPD], coronary aortic bypass graft [CABG], etc.), no history of known allergies or drug intolerance to analyzed substances.  Exclusion Criteria:  Patients malnourished or with metastatic disease, pregnant, in poor general status (Karnofsky <80, Eastern Cooperative Oncology Group (ECOG) > 1), recent history of severe heart, lung, kidney or liver failure, history of allergies or drug intolerance