Inclusion Criteria:  Inclusion Criteria:  Patient must have a non-healing ulcer associated with diabetes mellitus Ulcer must have a minimum surface area of 0.5cm2 and a maximum surface area of 10.0cm2 i. Wound depth is not a criterion, though it will be documented throughout the study Failed conventional wound care treatments Amputation candidate  Exclusion Criteria:  Exclusion Criteria:  Co-morbidities which do not allow the ulcer to be linked to diabetic pathology will be excluded from the study  o This is intended to limit the number of probable causes/contributing factors related to the ulcer. Commonly associated conditions, such as peripheral vascular disease is not an exclusion criterion, though it is documented in form, Enrollment Application Form for VAWNY072020PRODFU (IRB692.F01)  Wounds with active infections or gangrene Active carcinoma(s) Wounds where bone is necrosing, avascular necrosis Multiple ulcers on the same foot/ankle