Inclusion Criteria:  Participants will be included if all the following criteria are met.  Able to give informed consent and undergo treatment < 72 hours of injury (consent may be given by LAR as necessary); Any adult or pediatric patient < 75 years of age; Target burn to be at least one discrete partial thickness (second degree) thermal burns <20% total body surface area (TBSA) on anybody surface except the face; Characteristics of treated wound (s) must be superficial to deep partial thickness wounds such that application of both PermeaDerm and Mepilex Ag is medically appropriate; Agrees to abstain from the use of any other wound covering device for the duration of the study unless determined by the individual site Principal Investigator to be medically necessary; Demonstrates the ability and willingness to follow the requirements of the protocol.  Exclusion Criteria:  Participants will be excluded if s/he meet any of the following criteria.  Pregnant or breastfeeding; Target burn ≥ 20% TBSA; Electrical burns, chemical burns, frostbite; Treatment with silver sulfadiazine prior to presentation; Has comorbidities and/or medications and/or health status that (at the discretion of the individual site Principal Investigator) could result in poor wound healing (some examples may include admission to intensive care unit, inhalation, or other significant burn associated conditions, uncontrolled and/or significant diabetes, peripheral vascular disease, active malignancy, autoimmune disease, smoking, drug abuse, renal failure, steroid usage.