Inclusion Criteria:  Patients ≥18 years of age with AKI requiring KRT  Exclusion Criteria:  Chronic kidney disease with estimated glomerular filtration rate <30 mL/min/1.73 m2 Non-end stage renal disease with extracorporeal ultrafiltration due to diuretic- resistant fluid overload Decision to limit therapeutic interventions History of solid-organ transplants Pregnancy