Inclusion Criteria:  Male or female, age greater than or equal to 18 years at the time of signing informed consent Body mass index (BMI):  greater than or equal to 27.0 kg/m^2 with the presence of at least one of the following weight-related complications (treated or untreated): hypertension, dyslipidaemia, obstructive sleep apnoea or cardiovascular disease OR greater than or equal to 30.0 kg/m^2  History of at least one self-reported unsuccessful dietary effort to lose body weight  Exclusion Criteria:  HbA1c greater than or equal to 6.5% (48 mmol/mol) as measured by the central laboratory at screening A self-reported change in body weight greater than 5 kg (11 lbs) within 90 days before screening irrespective of medical records