Inclusion Criteria:  Recent onset group  age > 12 months and < 15 years recently diagnosed type 1 diabetes according ISPAD criteria  At risk subjects:  age > 12 months and < 15 years siblings of type 1 diabetic patient HLA DR3 and DR4 positive  Control subjects:  age > 12 months and < 15 years no HLA associated with high risk type 1 diabetes no antibodies against pancreas antigenes  Control subjects for UGI endoscopy:  age > 12 months and < 15 years suspicion of coeliac disease or gastritis  Exclusion Criteria:  For all groups:  no health care insurance parents or tutors unable to sign the consent personnal history of autoimmune disease and/or inflammatory disease except from T1D for RD and CE groups use of corticosteroids during the month before inclusion pregnant subjects medical contraindication of anesthetic topics  For control subjects for UGI endoscopy control and Recent onset-endoscopy groupe:  age below 8 years for Recent onset-endoscopy groupe age below 4 for UGI endoscopy control group cardiac or respiratory insufficiency, cardiac rythme disorders, coagulation disease, patients treated with anticoagulant or antiaggregant drug history of allergy to anesthetic drug