Inclusion Criteria:  1. Age ≥18 years old, both male and female; 2. Histologically confirmed glioblastoma; 3. Patients with glioblastoma who have failed standard treatment (surgery, Stupp regimen), were diagnosed by MRI and evaluated by RANO standard to support the first recurrence. Stupp regimen needs to complete at least 6 medication cycles.  Exclusion Criteria:  1. Use low molecular weight heparin and warfarin within 35 days before randomization; 2. Arterial or venous thrombosis (such as cerebral infarction, myocardial infarction, venous thrombosis of lower limbs, arterial embolism of lower limbs, pulmonary embolism, etc.) occurred within 6 months before randomization