Inclusion Criteria:  informed consent of participation in the study; systolic BP > 140 or diastolic BP > 90 mm Hg; type 2 diabetes mellitus (glucose tolerance test > 11.0 mmol/l, HbA1c>6,5%);  Exclusion Criteria:  secondary hypertension; type 1 diabetes mellitus; acute renal failure; traumatic kidney injury; toxic kidney injury; CKD G4 and G5 according to the KDIGO 2012; infectious diseases requiring active antibacterial and/or antiviral therapy; other severe diseases and conditions