Key Inclusion Criteria:  65 years of age or older at time of randomization Moderate aortic stenosis Subject has symptoms or evidence of cardiac damage/dysfunction The subject or subject's legal representative has been informed of the nature of the study, agrees to its provisions, and has provided written informed consent.  Key Exclusion Criteria:  Native aortic annulus size unsuitable for the THV Anatomical characteristics that would preclude safe placement of the introducer sheath or safe passage of the delivery system Aortic valve is unicuspid or non-calcified Bicuspid aortic valve with an aneurysmal ascending aorta > 4.5 cm or severe raphe/leaflet calcification Pre-existing mechanical or bioprosthetic aortic valve Severe aortic regurgitation Prior balloon aortic valvuloplasty to treat severe AS LVEF < 20% Left ventricular outflow tract calcification that would increase the risk of annular rupture or significant paravalvular leak post-TAVR Cardiac imaging evidence of intracardiac mass, thrombus, or vegetation Coronary or aortic valve anatomy that increases the risk of coronary artery obstruction post-TAVR