Inclusion Criteria:  Age ≥ 18 years old; A clinical indication for Fluorodeoxyglucose (FDG or 18F-FDG) PET/CT examination according to current clinical practice standards; Have ≥ 1 WHO Karnofsky index < 70; Are able to maintain a supine position twice; Are affiliated with a Social Security scheme in France; AND, Are able and willing to provide informed consent for participation in this study, per the EC approved policy.  Exclusion Criteria:  Have uncontrolled diabetes; Have a formal contraindication to certain imaging examinations (i.e., significant claustrophobia, or other contraindications as determined by the ordering physician.) Are known to be pregnant or breastfeeding (the investigational site will follow their standard practice of verifying for women of childbearing age; OR, Are known to have any psychological, family, geographic, or sociological condition that does not allow compliance with the medical monitoring and/or the procedures provided for in the study protocol.