Inclusion Criteria:  Advanced non-small cell lung cancer diagnosed by histology or pathology, and has progressed after first-line treatment with tislelizumab combined with platinum-containing dual-drug chemotherapy Patients who have progressed after first-line tislelizumab treatment for more than 3 months No EGFR, ALK gene mutations (the genetic test is not required for patients with lung squamous cell carcinoma) At least one measurable lesion (RECIST standard version 1.1) The expected survival period is ≥3 months The ECOG-PS score is 0-2 points  Exclusion Criteria:  The tumor histology or cytology is confirmed to be mixed adenosquamous carcinoma or combined with small cell lung cancer Known or suspected active autoimmune diseases A history of immunodeficiency or other acquired or congenital immunodeficiency diseases, or a history of organ transplantation and history of allogeneic bone marrow transplantation Interstitial lung disease, drug-induced pneumonia, radiation pneumonia requiring steroid therapy or clinical symptoms, active pneumonia or severe lung dysfunction Symptomatic brain metastases Those who are known or suspected to be allergic to test drugs and their excipients Women who are pregnant or breastfeeding