Inclusion Criteria:  Patients who met the diagnostic criteria of recurrent / refractory AML (WHO 2016)(primordial cells in bone marrow ≥ 5%) (excluding APL and bcr-abl positive AML ) and unerwent treatment. Patients who meet the diagnostic criteria of recurrent / refractory MDS (WHO 2016)and underwent treatment. Patients with recurrent / refractory Essential thrombocythemia (WHO2016) after treatment (for Phase Ia) Male or female subject above 18 years old Eastern Cooperative Oncology Group Performance Status (ECOG PS) performance status 0 ~ 2. Must have adequate organ function  Exclusion Criteria:  Previous history with myeloproliferative Neoplasms(MPN) or MDS/MPN Transformation or treatment related AML/MDS. PV/MF/AML/MDS eloved from Essential thrombocythemia Relapse after allogeneic hematopoietic stem cell transplantation, or autologous hematopoietic stem cell transplantation within 1 year Central nervous system leukemia infiltration Previous history of chronic hemolytic anemia or screening Coombe test positive Previous exposure to any anti-CD47 monoclonal antibody, SIRPα antibody, or CD47/SIRPα recombinant protein. Previous exposure to chimeric antigen receptor T cell immunotherapy (CAR-T) Patients who received immunotherapy, targeted therapy, biological therapy or any clinical research treatment within 14 days before receiving the first dose Uncontrolled concurrent diseases Subjects who are allergic to the ingredients of the study drug Subjects who have used immunosuppressive drugs within 7 days before the first dose of study treatment