Inclusion Criteria:  Patients with clinical bone defects or need for bone fusion; Age 18 to 65, and gender is not limited; Informed consent has been signed.  Exclusion Criteria:  Age less than 18 or greater than 65; Patients with severe deformities of the iliac bone or extensive defects of the iliac bone, which are not suitable for bone extraction; Patients with coagulation dysfunction; Patients who are unwilling to perform iliac bone extraction; BMI & lt; = 18.5 kg/m2; Patients with type I and type II diabetes; Osteoporosis(T & lt; = -2.5); Moderate and severe anemia(hemoglobin & lt; 9g/L) or hypoproteinemia(albumin & lt; 30g/L); Patients with malignant neoplasms; Patients with mental illness and those who are unconscious and unable to express themselves accurately.