Inclusion Criteria:  Age ≥ 5 years old, ≤ 75 years old; After MDT discussion, routine surgery can be performed, and the postoperative pathology is clear as pancreatic cancer and other pancreatic diseases; No history of antibiotics for three months before surgery, no history of yogurt containing probiotics There is no serious damage to heart, liver and kidney function.  Exclusion Criteria:  Antibiotics or yogurt containing probiotics history in three months; Patients with evidence of sensory or motor neuropathy; Those who have a clear cardiovascular disease, severe associated disease or active infection, including known HIV infection; Those who have a history of other cancers.