Inclusion Criteria:  All patients between 18 and 75 years with diagnosed diabetes mellitus, according to WHO criteria. Proven peripheral neuropathy. Written consent with documentation that all participants received relevant information about this study is given to the patient. The participants must be willing and able to meet the planned visit and meet the planned schedule, including participation in the experimental investigations.  Exclusion Criteria:  Health professionals' assessment makes the patient have medical or surgical diseases unsuitable to participate in the study. Pregnancy or breastfeeding for female patients. Competitive conditions that can cause peripheral neuropathy. Participants involved in the planning or execution of the study.