Inclusion Criteria:  Patients treatable for HNSCC (palliative), NSCLC (separately palliative and adjuvant) or "other solid tumour" Indication for system therapy with a PD-1/PD-L1 inhibitor according to clinical standards Patients without or with radiation of one or more metastases Age at least 18 years  Exclusion Criteria:  Melanoma patients Fertile patients who refuse effective contraception during study treatment Persistent drug and/or alcohol abuse Patients not able or willing to behave according to study protocol Patients in care Patients that are not able to speak German Patients which are imprisoned according to legal or governmental order  Both gender are included into the study, a maximum age was not defined.