Inclusion Criteria:  Healthy Chinese male and female participants No clinical relevant abnormalities willing and able to comply with all study procedures BMI:17.5-30.5 Sign informed consent  Exclusion Criteria:  Any clinical significant illness History of alcohol abuse Use within 14 days prior the first study dose CL>80ml/min Abnormal vital signs, such 12-ECG, blood pressure and pulse rate Blood donation within 60days History of HIV, HBsAg, HBcAb, HCVAb Other medical or psychiatric may inappropriate for the study