Inclusion Criteria:  Parent/guardian willing and able to provide informed consent; assent will be sought for participants between 12 and <16 years of age Resident of the defined study area, Kisantu Health Zone at the time of vaccination Age between 9 months and <16 years (i.e., ≤15 years and 364 days) on the day of vaccination  Exclusion Criteria:  The participant has a known allergy to any of the vaccine components, Any medical reason perceived to increase risk to health posed by vaccination as judged by a medical professional Self-reported pregnancy in females greater or equal to 11 years of age who have reported menarche