Inclusion Criteria:  Age ≥ 18 years Willing to sign informed consent Patient with CT scan or MRI or EUS defining the lesion as locally advanced Patient who already underwent EUS-TA for solid lesion of the pancreas positive for pancreatic ductal adenocarcinoma (PDAC) Patient undergoing neoadjuvant chemotherapy Patient primarily followed at San Raffaele Hospital  Exclusion Criteria:  Patients not willing to sign informed consent Pregnancy and breastfeeding Cytology positive for malignancies other than PDAC Patient undergoing progression at re-staging CT scan