Inclusion Criteria:  Participant is willing and able to give informed consent for participation in the study. Male or Female, aged 18 years to 75 years.  Malignancy Cohort: extra inclusion criteria - Diagnosed with a malignancy or with clinical suspicion of a malignancy affecting the Liver or Biliary Tree.  Control cohort: extra inclusion criteria  - Patients with confirmed chronic non-malignant hepatobiliary disease.  Additional Inclusion Criteria for Patients Undergoing optional Liver FNA  Willing to undergo ultrasound guided liver FNA (unless specific contra-indications to the procedure apply). Has undergone appropriate clinical imaging of the upper abdomen (US/CT/MRI) within the last 12 months. Full blood count (FBC) and coagulation profile (Coag) checked within 30 days prior to FNA procedure (Baseline Visit).  Exclusion Criteria:  Unable to consent. Pregnancy. Any concern by the investigator regarding the safe participation of the patient in the study; or investigator's consideration, for any other reason, that a patient is inappropriate for participation in the study.  Additional Exclusion Criteria for Patients Undergoing optional Liver FNA (These criteria will exclude a patient from having FNA as part of the study)  Significant comorbid medical condition(s) which may in the opinion of the investigator increase the risk of an FNA Liver. Coagulopathy - International Normalized Ratio (INR) >1.3, Prothrombin Time (PT) >16 seconds, Platelet count <100 x 10^3/L. Known bleeding disorder (e.g. Haemophilia). Current use of an oral/injectable anticoagulant medication. Current use of an oral antiplatelet agent. The presence of ascites.