Inclusion Criteria:  Age≥18 Years and <80 years; ACS patients eligible for percutaneous coronary intervention; Successful preparation is defined as ≤ 30% residual stenosis with Thrombolysis in Myocardial Infarction (TIMI) Grade III flow and not evidence of type C-F dissection; Vessel diameter from 2.25mm-4.0 mm ; Lesion length ≤ 28 mm; A single culprit lesion or 1 lesion in each of two vessels ; Eligible for enrollment and provide written informed consent.  Exclusion Criteria:  Clinical Exclusion Criteria：  Stable angina or asymptomatic myocardial ischemia; Cardiogenic shock or requiring mechanical support for breathing and circulation; Hemodynamically unstable tachyarrhythmia or bradyarrhythmia; Plan to perform cardiac surgery or non-cardiac surgery within 24 months of percutaneous coronary intervention; A history of stroke within 6 months; History of severe renal insufficiency; Life expectancy < 12 months; Pregnant women; Allergies to aspirin, clopidogrel, ticagrelor, heparin, contrast agents, and paclitaxel, patients with systemic lupus erythematosus or other systemic immune diseases; Patients not suitable for enrollment considered by researcher; Currently participating in another trial before reaching the primary endpoint; Inability to provide informed consent. Image Exclusion Criteria  1. Chronic total occlusion (CTO); 2. Left main lesion; 3. Bifurcation lesions treated with double stents; 4. Moderate to severe distortion, angulation or severe calcification lesions; 5. Coronary artery graft stenosis; 6. In-stent restenosis; 7. To be re-hospitalized for the other scheduled PCI treatment; 8. Myocardial bridge at the target lesion.