Inclusion Criteria:  Age ≥3 months Willingness to comply with trial procedures and written informed consent to be obtained at the beginning of the study  Exclusion Criteria:  Severe illness or self-reported chronic illness (e.g., HIV, tuberculosis, heart/liver/kidney disease, and severe malnutrition) Known hypersensitivity to study drug  Additional exclusion criteria for DHA-PPQ:  First trimester pregnancy assessed by history and/or urine pregnancy testing Concurrent artemisinin-based combination therapy (ACT) use Taking drugs that influence cardiac function or prolong QTc interval  Additional exclusion criteria for PQ:  Pregnancy (any trimester) or currently breastfeeding an infant <6 months of age assessed by history and/or urine pregnancy testing <2 years of age