Inclusion Criteria:  Signed informed consent, inclusive of release of medical information Age ≥ 18 years CAD with indication for revascularization  Coronary anatomy as follows:  Multivessel-CAD involving the left anterior descending (LAD) (proximal or mid) and/or the left main (LM) (ostial, mid-shaft or distal) with at least one further epicardial coronary artery requiring treatment (LCX or RCA), OR Single vessel disease involving the LAD and a major diagonal, both requiring independent revascularization with at least one stent Severe aortic stenosis/insufficiency and/or mitral stenosis/insufficiency requiring surgery, with CAD (involving one or more vessels), suitable for PCI CAD with indication for revascularization with severe unilateral carotid stenosis (>85%)  Ability to tolerate, and no plans to interrupt dual antiplatelet therapy (DAPT) for:  At least 6 months in presentation was stable CAD, At least 12 months if presentation was a biomarker-positive acute coronary syndrome (ACS) Willing to comply with the follow-up required by the protocol.  Exclusion Criteria:  Previous cardiac surgery of any kind Previous thoracic surgery involving the left pleural space (if a left thoracotomy approach is planned) Complicated or unsuccessful PCI within 30 days prior Total occlusion (TIMI 0 or 1 flow) of the LM or LAD Cardiogenic shock at time of screening Any prior lung resection End-stage renal disease on dialysis Extra-cardiac illness that is expected to limit survival to less then 5 years Allergy or hypersensitivity to any of the study drugs or devices used in protocol Patient unable to give informed consent or potentially noncompliant with the study protocol, in the judgement of the investigator Pregnant at time of screening, or unwilling to use effective birth control measures while dual antiplatelet therapy is required.