Inclusion Criteria:  -  The inclusion criteria of ALS patients:  They met the diagnostic criteria of Chinese guidelines for the diagnosis and treatment of amyotrophic lateral sclerosis; ② Receiving care at home; ③ No cognitive impairment (if the patient is unable to talk and write due to illness, the family members can express it for the patient);  ④ Informed consent, willing to participate in this study;  ⑤ No mental illness.  The inclusion criteria of caregivers: ① the primary caregiver designated by the patient was responsible for the primary care;  They are relatives of patients;  No payment for care; ④ Informed consent, willing to participate in this study;  No mental illness; ⑥ There was no cognitive impairment.  Exclusion Criteria:  -  Exclusion criteria of ALS patients:  ① severe physical diseases, such as malignant tumor, liver and kidney dysfunction, etc;  ② They are participating in other intervention projects.  Exclusion criteria of caregivers:  severe physical diseases, such as malignant tumor, liver and kidney dysfunction, etc; ② They are participating in other intervention projects.