Inclusion Criteria:  Histologically confirmed, locally advanced unresectable or metastatic tumors. At least one evaluable or measurable lesion per RECIST 1.1 Male or female subject at least 18 years old and no more than 75 years old. Eastern Cooperative Oncology Group Performance Status (ECOG PS) performance status 0 or 1. Must have adequate organ function Be able to provide archived or fresh tumor tissues-  Exclusion Criteria:  Previous exposure to any anti-CD73 monoclonal antibody Subjects participating in another interventional clinical study, except for during the survival follow-up phase of the studies. Unstable central nervous system netastases Known active autoimmune disease or inflammatory disease Known active infectious disease Other uncontrolled systematic disease that may increase the risk of participating the study-