Inclusion Criteria:  Scheduled to undergo arthroscopic shoulder surgery. American Society of Anesthesiology Physical Class 1-3. Ability and willingness to provide informed consent.  Exclusion Criteria:  Not willing to adhere to the study visit schedule. With a history of hypersensitivity or allergy to opioids, NSAIDs or sesame oil. With a medical history that may predispose them to abnormal intracranial pressure. Any history of narcotic dependency, addiction, or withdrawal. Any clinically significant condition that may interfere with study assessments. Pregnant or breastfeeding. Nonregular sinus cardiac rhythm or implanted pacemakers. Prescribed antimuscarinic agents, α2-adrenergic agonists, β1-adrenergic antagonists, or antiarrhythmic agents.