Inclusion Criteria:  Age ≥ 18 years Seropositive for HIV-1 Recipient of ART Plasma HIV-RNA < 500 copies/ml Patients written consent obtained  Exclusion Criteria:  Pregnancy or breastfeeding History of meningococcal or pneumococcal vaccination Allergies towards any of the vaccine components Temperature > 38 ᵒC Sign of bacterial infection Previous known or suspected disease caused by N. meningitidis Active AIDS associated illness Active malignancy End-stage renal or liver disease Bleeding disorder Recipient of any blood, blood products and/or plasma derivatives or any parenteral immunoglobulin preparation within the last month Use of immunosuppressive agents (corticosteroids, cancer chemotherapeutic agents etc.)