Inclusion Criteria:  Between 18-65 years of age Presenting to Upstate Adult Emergency Department at either the Downtown or Community campuses. Diagnosed with isolated/acute urticaria Requires treatment with antihistamines to alleviate symptoms  Exclusion Criteria:  Pregnant women Prisoners Patients with altered mental status/have impaired decision-making capacity. Presenting with symptoms suggesting life threatening illness or anaphylaxis. Patients who have received any antihistamine (H1 antagonist) within the past 2 hours via any route of administration. Patients who have received an H2 antagonist within the past 2 hours. Patient received steroids by any route within the past 4 hours. Patient received epinephrine within the past 20 minutes. Patients currently taking concomitant p-glycoprotein inhibitors. Patients on any of the following CYP2D6 inhibitors: Bupropion, Fluoxetine, Paroxetine, Quinidine, Tipranavir. Patients with a history of serotonin syndrome. Patients currently taking another tricyclic antidepressant, selective serotonin reuptake inhibitor, and/or serotonin-norepinephrine reuptake inhibitor. Patients who have a condition where an antihistamine may be contraindicated. Patients with a contraindication to anticholinergic medications. History of adverse effects to tricyclic antidepressants or antihistamines. Patient who, based on their medical history or in the opinion of the clinician, have chronic urticaria, urticaria refractory to antihistamines, or dermatological disease that interferes with evaluation of a therapeutic response. Patients taking antileukotriene compounds (montelukast), calcineurin inhibitors (tacrolimus) or anti-serotonin agents (cyproheptadine)