Inclusion Criteria:  Age 18-65; 1.0-7.5 points on the EDSS scale (for MS); Length of illness - any; Disease progression during the last 6 months while taking drugs of 1st and 2nd lines; An established and confirmed diagnosis of an autoimmune disease in the previous stages of treatment; Ineffectiveness, inaccessibility or intolerance of Disease-Modifying Therapies; Relapse after AHSCT. Absence of severe concomitant somatic pathology; Left ventricular injection fraction > 50%; Karnofsky Performance Score (KPS) > 30%; The ability to take oral medications; Life expectancy is more than 1 month; Signed informed consent of the patient or legal representatives.  Exclusion Criteria:  Moderate or severe cardiac dysfunction, left ventricular ejection fraction <50% Moderate or severe decrease in pulmonary function, FEV1 <70% or DLCO<70% of predicted Respiratory distress >grade I Severe organ dysfunction: AST or ALT >5 upper normal limits, bilirubin >1.5 upper normal limits, creatinine >2 upper normal limits Creatinine clearance < 60 mL/min Uncontrolled bacterial or fungal infection at the time of enrollment Requirement for vasopressor support at the time of enrollment Karnofsky performans status <30% Pregnancy Somatic or psychiatric disorder making the patient unable to sign informed consent