Inclusion Criteria:  Be over 18 years of age (at the time of inclusion); Be suspected of developing leptospirosis by the clinician in one of the 5 participating centres Have been informed of the use of their samples for non-therapeutic scientific research purposes by a note and information sheet established by the Institut Pasteur of New Caledonia (IPNC) and the Institut Pasteur Paris (IPP), provided and explained by the inclusion centre. Have expressed their oral consent to participate in this research project  Non inclusion criteria:  Under 18 years of age Have not given oral consent to participate Have a chronic inflammatory disease. Having concomitant antibiotic and/or anti-inflammatory treatment or medical management incompatible with the purpose of the study, Pregnant or breastfeeding women.  Exclusion Criteria:  - Leptospirosis diagnostic is not confirmed by molecular biology. Complete destruction of the corresponding samples will be ensured. Clinical data and biological analyses will also be removed from the data associated with the research.