Inclusion Criteria:  Patients will be eligible for inclusion if all of the inclusion criteria are met:  1.Sepsis-3 criteria from Society of Critical Care Medicine (SCCM) /European Society of Intensive Care Medicine (ESICM), and the infection site is from abdomen 2.18≤ age ≤75years 3.obtain informed consent  Exclusion Criteria:  The primary site of infection is from other parts (such as lungs, intracranial, etc.) except abdomen Diagnosis of sepsis for more than 48 hour Pregnant and lactating women Severe primary disease including unrespectable tumours, blood diseases and Human Immunodeficiency Virus (HIV); Have a known or suspected adverse reaction to UFH including HIT Have bleeding or high risk for bleeding Have an indication for therapeutic anticoagulation or have taken anticoagulants within 7 days Use of an immunosuppressant or having an organ transplant within the previous 6 months Participating in other clinical trials in the previous 30 days Have received cardiopulmonary resuscitation within 7 days Have terminal illness with a life expectancy of less than 28 days