Inclusion Criteria:  Subjects join the study voluntarily and sign informed consent; Female subjects are older than 18 years; ECOG(Eastern Cooperative Oncology Group) physical status score is 0-2; Life expectancy≥3 months; Histologically confirmed FIGO(International Federation of Gynecology and Obstetrics ) III/IV ovarian cancer, fallopian tube cancer, or primary peritoneal cancer; Participants must have high-grade serous histology  Exclusion Criteria:  Personnel involved in the formulation or implementation of the research plan; The subjects had other malignant diseases in past 2 years, except skin squamous cell carcinoma, basal-like carcinoma, breast intraductal carcinoma in situ, or cervical carcinoma in situ;