For symptomatic patients attending to the SFXH or other satellite health centers  Inclusion Criteria  Patients > or =16 years of age Presenting respiratory symptoms Positive respiratory sample for SARS-CoV-2 or other respiratory infections included in the panel Possibility to be contacted during follow-up Consented participation Patients which households are located within the study catchment area  Exclusion Criteria  Symptomatic patients who test negative for all pathogens of the PCR-based respiratory panel. Symptomatic patients who test negative for the SARS-CoV-2 RDT and do not meet the matching criteria (age and residency (community)) as symptomatic controls to any of the recruited cases (to be considered as controls for the Antimicrobial Use Workpackage)  Antimicrobial Use Work package (A subset of hospitalized, symptomatic patients are to be recruited as control group for the Antimicrobial Use Workpackage, if they meet the inclusion criteria)  Inclusion Criteria  Patients > or =16 years of age Presenting respiratory symptoms Negative respiratory sample for SARS-CoV-2 (RDT) Do not meet the matching criteria (age and residency (community)) as symptomatic controls to any of the recruited cases Admitted to SFXH Consented participation  For healthy controls from the community  Inclusion Criteria  Patients > or =16 years of age Meet the age and residency (community) criteria to be matched to the cases Possibility to be contacted during follow-up Consented participation  Exclusion Criteria  Presenting COVID-19 like symptoms Positive for SARS-CoV-2 RDT Eligible participants in the community presenting with an acute illness can be considered for inclusion as a case and recommended for referral to SFXH/ satellite health centre.