Inclusion Criteria:  Healthy male and female aged 19 to 65 years old Participants with Facial Wrinkle Scale (FWS) score of > 2 at maximum frown at screening Participants willing to follow the study procedures and schedules Participants willing to give written informed consent to participate in the trial  Exclusion Criteria:  Participants with severe glabellar lines that cannot be improved physical method Pregnant, lactating women or women of childbearing age not using a reliable method of contraception Participants with known hypersensitivity to any component of the study drug Participant who has skin disorder including infection and scar on injection site