Inclusion Criteria:  Female gender Age ≥ 45 cT1-2N0, <3.5cm invasive breast cancer, estrogen-receptor positive or DCIS of breast, Grade 1-2, mammographically detected, < 2.5 cm, estrogen-receptor positive Suitable for breast conserving surgery No contraindication to radiation Mammogram within 6 months of planned procedure Fitness for lumpectomy under general anesthesia Planned to receive IORT  Exclusion criteria  Known axillary lymph node positive breast cancer (negative biopsy not required) Multicentric cancer in the same breast as diagnosed by clinical examination, mammography, ultrasound, MRI or pathologic assessment, not amenable to excisionwith negative margins with a single lumpectomy. Patients known to have BRCA 1/2 gene Patients undergoing neoadjuvant chemotherapy