Inclusion Criteria:  Able to understand and sign an approved Informed Consent form; Willing and able to attend all scheduled study visits as required by the protocol; Currently wearing any commercial spherical weekly/monthly soft contact lenses in both eyes for at least 3 months, minimum 5 days per week, 10 hours per day; Manifest cylinder less than or equal to 0.75 diopter (D) in each eye; Willing to stop wearing habitual contact lenses for the duration of study participation. Other protocol-defined inclusion criteria may apply.  Exclusion Criteria:  Any eye condition that contraindicates contact lens wear, as determined by the Investigator; Any use of systemic or ocular medicine that contraindicates contact lens wear, as determined by the Investigator; Ocular or intraocular surgery (excluding placement of punctal plugs) within the previous 12 months or planned during the study; Any use of topical ocular medications and artificial tear or rewetting drops that would require instillation during contact lens wear; Current or prior Biofinity contact lens wear in the past 3 months prior to consent. Other protocol-defined exclusion criteria may apply.