Inclusion Criteria:  Age 18 years or older Presentation with a 50-99% de novo SVG lesion SVG lesion that is considered to cause clinical symptoms and is treated with percutaneous coronary intervention of the corresponding native coronary artery using a SYNERGY stent. Has provided informed consent and agrees to participate  Exclusion Criteria:  1. Known comorbidities/ conditions that, in the opinion of the investigator, limit life expectancy to less than 1 year