Inclusion Criteria:  Caucasian (people will be excluded when having a ≥50% racial African/Asian background) Male or postmenopausal female Aged 45-75 years at start of the study Body mass index (BMI) 27 - 38 kg/m2 Stable dietary habits (no weight loss or gain >3kg in the past 3 months) Sedentary lifestyle (not more than 2 hours of vigorous exercise per week)  Exclusion Criteria:  Type 2 diabetes (fasted blood glucose > 7 mmol/L) Any condition or medical history that would in the investigator's or dependent physician's opinion interfere with the study, with study outcomes or increase the risk of the study procedures Alcohol consumption of >2 servings per day Smoking Low Hb (men: <8.6 mmol/L; women <7.4 mmol/L) Use of medication known to interfere with the safety of study procedures Use of medication known to increase liver fat, like for instance corticosteroids (parenteral & oral chronic administration only), amiodarone (Cordarone), tamoxifen (Nolvadex), and methotrexate (Rheumatrex, Trexall). Subjects receiving thiazolidinediones (glitazones [pioglitazone, rosiglitazone]). Participation in research or medical examination that included PET/CT scanning in the last 3 months Contra-indication for MRI