Inclusion Criteria:  20 years of age and above. clinically symptomatic and electrophysiologically confirmed carpal tunnel syndrome. no response to conservative treatment. Signed Informed Consent and willing to comply with doctors and nurses' order.  Exclusion Criteria:  Subjects with recurrent carpal tunnel syndrome Subjects with coexisting cervical radiculopathy Subjects treated with systemic immunosuppressive or glucocorticosteroids, except subjects taking occasional doses or doses less than 10mg prednisolone per day or equivalent. Diabetic patients with pre-OP HbA1c >7% Subject included in other ongoing clinical investigation which could interfere with this investigation, as judged by the investigator Known allergy/hypersensitivity to any of the components included into the investigation.