Inclusion Criteria:  Diagnosis of multiple sclerosis according to established international criteria Steroid free period: > 4 weeks Participation in the Swiss MS Cohort (SMSC) study  Exclusion Criteria:  . History of severe (other) neurological, internal or psychiatric disease with SC affection  MRI-related exclusion criteria (questionnaire):  Paramagnetic and/or superparamagnetic foreign objects in the body (especially when located close to the SC) Pacemaker Claustrophobia Pregnancy, lactation Known hypersensitivity to gadolinium-based contrast media