Inclusion Criteria:  Breast volume > 800 ml BMI< 25 if under 50 years of age and BMI<2 if over the age of 50 Symptoms of breast hypertrophy Non-smokers  Un-operad controls:  -Symptoms of breast hypertrophy, but do not comply with the criteria above.  Augmented controls:  Augmented breast volume > 800 ml BMI< 25 if under 50 years of age and BMI<2 if over the age of 50  Exclusion Criteria:  Inability to provide informed consent Inability to understand the Swedish language Age under 18 years