Inclusion Criteria:  Male and / or female patients aged 18-65 will be included in the study. Normal left ventricular function (alternating one, two and three vessels). coronary artery patients scheduled for elective coronary artery surgery under cardiopulmonary bypass, Valvular diseases planned for elective valve replacement with normal left ventricular function, ASD (Atrial Septal Defect) cases for atrial septal defect closure, and patients without left ventricular dysfunction (E / F≥ 50-55%) elective valve + CABG will be included in the study.  Exclusion Criteria:  Patients requiring acute coronary syndrome and emergency cardiovascular surgery, Patients who have had myocardial infarction within the past month Recurrent cardiovascular surgery Off-pump coronary artery bypass surgery (OPCAB) Patients with chronic inflammatory disease (rheumatoid arthritis, malignancy, psoriasis, etc.), autoimmune disease, immunocompromised patients Patients with chronic renal failure, liver disease, active infection Patients older than 80 years and smaller than 18 years Patients with coagulation disorders