Inclusion Criteria:  Healthy subjects Age between 18 and 40 years Participant is able and willing to give informed consent.  Exclusion Criteria:  Unable to understand and speak Danish Non-cooperative Chronic pain or acute pain the past week lasting more than 4 hours or pain on the day of investigation Pain medication within the last week Medication within the last week that can affect assessment Psychiatric or neurological disease and diseases that may affect the assessment Sensory disturbances History or symptoms of significant diseases (e.g. psychiatric or neurological disease, diseases that may affect the assessment, sensory disturbances, cancer, diabetes mellitus, liver diseases, kidney diseases, cardiovascular diseases) Pregnancy or lactation Jetlag or sleep deprivation Alcohol or drug abuse Consumption of cannabis the last 4 weeks and consumption of alcohol in the last 48 hours Any abnormality of the skin or of vascular origin at application site History of hypersensitivity to lidocaine, other amide-type anesthetics, or other contents of the lidocaine or vehicle