Inclusion Criteria:  Patients with stage 5 CKD (GFR < 15 mL/min); On hemodialysis for more than 6 months; Who have arteriovenous fistula (AVF) as vascular access  Exclusion Criteria:  Pregnant women; Smokers; Using antibiotics in the last 3 months; Using antioxidant supplements; Who have habitual intake of propolis, curcumin and turmeric; With autoimmune and infectious diseases, cancer, liver and AIDS (Acquired Immunodeficiency Syndrome)