Inclusion Criteria:  Histologic diagnosis of breast cancer with documentation of ER/PR/HER2 status Radiographic evidence of stage IV extracranial disease having progressed past first line therapy Age ≥ 18 Life expectancy ≥ 6 months Eastern Cooperative Oncology Group performance status 0 to 2 Patients must be able to understand and the willingness to sign an informed consent for study procedures Stated willingness to comply with all study procedures and availability for the duration of the study  Exclusion Criteria:  Prior diagnosis or treatment of brain metastases or leptomeningeal disease Patients with prior history of non-breast cancer malignancies should have no evidence of disease ≥ 2 years Neurologic symptoms warranting standard screening brain MRI in the judgement of the treating physician at time of enrollment Indications warranting brain MRI for other neurologic conditions at time of study entry Contraindication towards MRI imaging with contrast Chronic kidney disease stage IV or V or end stage renal disease