Inclusion Criteria:  Participants who participated in the Phase III clinical study of a recombinant human papillomavirus 16/18 bivalent vaccine in females (Unique Protocol ID: HPV-PRO-003, Identifiers: NCT01735006) and received at least one dose; Participants can fully understand the study content and sign an informed consent form； Able to comply with the requests of the study;  Exclusion Criteria:  Participants used other HPV vaccine products (including both marketed and unmarketed vaccines) since participating in the Phase III clinical study. According to the investigator's judgment, there might be some medical, psychological, social or occupational factors which might impact on the individual to obey the protocol or sign the informed consent;