Inclusion Criteria:  Continuous non-smoker participant who has not used nicotine-containing products for >= 3 months before the first dose Have body mass index of >= 18.0 and <= 32.0 kg/m^2 at screening Medically healthy with no clinically significant medical history, physical examination, laboratory profiles, vital signs, or electrocardiograms (ECGs), as deemed by the principal investigator (PI) No clinically significant history or presence of ECG findings as judged by the PI or qualified designee at screening and each check-in, including each criterion as: 1) Normal sinus rhythm (heart rate between 50 and 100 beats per minute [bpm]), 2) QTcF interval ≤ 450 milliseconds (msec), 3) QRS interval ≤ 110 msec, and 4) PR interval ≤ 220 msec Women participants must be of non-childbearing status Women participants must have negative serum pregnancy test ability to swallow multiple capsules and/or tablets using size 0 blank capsules (up to a maximum of 5 capsules per participant) Male participants must be willing to use protocol specified contraception methods  Exclusion Criteria:  Participant is mentally or legally incapacitated or has significant emotional problems at the time of the screening visit or expected during the conduct of the study History of any illness that, in the opinion of the PI, might confound the results of the study or poses an additional risk to the subject by their participation in the study Presence of any clinically significant, ongoing systemic bacterial, fungal, or viral infections (including upper respiratory tract infections, but excluding localized cutaneous fungal infections), in the opinion of the PI History of any major surgical procedure within 30 days before the first dose of study drug History or presence of alcoholism or drug abuse within the past 2 years before screening Any clinically significant condition that may affect ACP-196 absorption in the opinion of the PI, including gastric restrictions and bariatric surgery (eg, gastric bypass). Allergy to band-aids, adhesive dressing, or medical tape History or presence of clinically significant thyroid disease Prior exposure to Bruton's tyrosine kinase inhibitors (eg, ACP-196, ibrutinib) within 3 months before the first dose of study drug Positive urine cotinine at screening Positive urine drug or alcohol results at screening or each check-in Positive for human immunodeficiency virus (HIV), hepatitis B surface antigen (HBsAg), or hepatitis C virus (HCV) at screening Seated blood pressure is less than 90/40 mmHg or greater than 140/90 mmHg at screening Seated heart rate is lower than 50 bpm or higher than 99 bpm at screening Unable to refrain from or anticipates the use of protocol defined medications for 28 days before the first dose of study drug and throughout the study