Inclusion Criteria:  Age ≥ 18 years of age, gender-neutral; Diagnosed with sepsis shock; ICU survives longer than 48 h; The preservation of clinical data is complete;  Exclusion Criteria:  - Diagnosed with sepsis shock within 6 hours of emergency treatment; Combined with people with autoimmune diseases; 3. Organ transplantation or immunosuppressive treatment; 4. Severe heart, liver and kidney insufficiency; 5. Late stage of malignant tumor; 6. Maternity; 7. Referral or referral to another hospital;