Inclusion Criteria:  Body Mass Index (BMI) between 18 and 40 kilograms per meters squared (kg/m^2), inclusive Clinical diagnosis of acute ischemic stroke (AIS) in anterior circulation, supported by acute brain computed tomography (CT) scan or magnetic resonance imaging (MRI) consistent with the clinical diagnosis. Able to be randomized and dosed within 7 days of index stroke event. The last known awake time will be used for participants whose stoke occurred during sleep. National Institute of Health Stroke Scale total score of 7 to 21, inclusive  Exclusion Criteria:  Evidence of severe stroke on imaging (e.g., sulcal effacement or blurring of gray-white junction in greater than 1/3 of middle cerebral artery [MCA] territory, Alberta Stroke Program Early CT [ASPECT] score of 0 to 4 based on head CT, acute infarct volume on MRI diffusion weighed imaging ≥70 milliliters (mL) based on acute imaging studies performed under the standard of care Lacunar or isolated brainstem or cerebellar stroke based on clinical assessment and available acute imaging studies performed under the standard of care Evidence of seizure at the onset of index stroke  Evidence of acute myocardial infarction (MI) at Baseline, including any of the following:  Acute ST elevation MI; Acute decompensated heart failure, or New York Heart Association Class III/IV heart failure; Admission for an acute coronary syndrome, MI, cardiac arrest, or non-voluntary coronary intervention (percutaneous coronary intervention or coronary artery surgery) within the past 3 months. QT interval corrected using Bazett's formula (QTcB) >520 milliseconds (msec)