Inclusion Criteria:  An age of >18 years; A CHA2DS2-VASc score of ≥2; Clinical conditions allowing TEE and sedation; Left ventricular ejection fraction >30%; And at least one of the following indications: (a) HAS-BLED score of ≥3; (b) intolerance to long-term OAC, and (c) stroke, transient ischemic attack, or thromboembolism even under oral anticoagulation treatment;  Exclusion Criteria:  A glomerular filtration rate of <50 mL/min/1.73 m2; The presence of a thrombus in the LA and LAA; Acute myocardial infarction or unstable angina, decompensated heart failure (New York Heart Association functional class III-IV), or heart transplantation; Stroke or transient ischemic attack within 30 days; Very poor peripheral vessel access not allowing device delivery; Moderate or massive pericardial effusion.