Inclusion Criteria:  Patients with acute ischemic stroke and large intracranial vessel occlusion within 24 hours after the onset of symptoms in whom mechanical thrombectomy has been performed. Successful recanalization, defined as a TICI score of 2b, 2c, or 3. Previous score on the modified Rankin scale (mRS) of 0, 1, or 2. The patient or her legal representative gives informed written or verbal consent  Exclusion Criteria:  ASPECTS score <6 Vertebral, basilar, A2, P2 and M3-4 occlusion History of intracerebral hemorrhage Pregnant or breastfeeding patient Patient with congestive heart failure or recent/unstable coronary artery disease (<3 months) Dissection of aorta, cervical or cerebral or unruptured aortic / cerebral aneurysm or known arteriovenous malformation Any bleeding visible on baseline CT History of ventricular arrhythmias Use of MAO inhibitors Inclusion in other clinical trials.