Inclusion Criteria:  patients with Recurrent miscarriage is defined as three or more consecutive pregnancy losses at or less than 20 weeks of gestation or with a fetal weight less than 500 grams  Exclusion Criteria:  A woman who had experienced recurrent pregnancy loss due to uterine anomalies, diabetes mellitus and thyroid disease. Hypertensive women. Patients with coagulation defects. History of deep vein thrombosis or pulmonary thromboembolism. Use of medications affecting platelet functions such as aspirin, nonsteroidal anti-inflammatory drugs, oral contraceptives, hormonal treatments, anti-platelet, and anticoagulant drugs.