Inclusion Criteria:  Healthy male Caucasian subject aged 18 to 50 years inclusive Body Mass Index (BMI) between 18 and 27 kg/m2 inclusive and body weight ≥ 50 kg at screening Signing a written informed consent prior to selection;  Exclusion Criteria:  Any history (including family history) or presence of cardiovascular, pulmonary, gastro-intestinal, hepatic, renal, metabolic, haematological, neurologic, psychiatric, systemic or infectious disease;