Inclusion Criteria:  Newly diagnosed AML according to the WHO (2016) classification of acute myeloid leukemia. No history of previous chemotherapy or target therapy. Neutrophil deficiency (ANC<0.5x10^9/L) with the first time fever(Oral temperature >=38.3 degree C or axillary temperature >=38.0 degree C) accompanied by chills or hemodynamic instability(BP <=90/60mmHg） Ability to comprehend the investigational nature of the study and provide informed consent.  Exclusion Criteria:  Patients have a history of chemotherapy or target therapy. Patients with other commodities that the investigators considered not suitable for the enrollment.