Inclusion Criteria:  for sedentary individuals: ≤700 METs/week measured by IPAQ for active individuals: ≥1000 METs/week measured by IPAQ  Exclusion Criteria:  Presence of cardiovascular and respiratory diseases Presence of Hypertension Presence of neurodegenerative diseases Pesence of acuteor chronic conditions that might influence inlfammatory response Any vascular Diabetes-related complication Drugs or alchol abuse Presence of other health-related condition that might affect the practice of physical activity.