Inclusion Criteria:  age older than 20 years of age admission with a confirmed positive test for SARS-CoV-2 infection by reverse transcription polymerase chain reaction (RT- PCR) disease onset (start of COVID-19 symptom and PCR test) for ≤ 120 hours available informed consent of this study.  Exclusion Criteria:  receiving oxygen supply before randomization known intolerance/allergy to the study drugs pregnancy sinus/oral operation within 30 days of the beginning of the study using intranasal medication before randomization no available informed consent inability to self-care or reply to questionnaire