Inclusion Criteria:  Familia partial lipodystrophy type 2 (FPL2) with the R482 codon mutation of the LMNA gene Social insured Ability to give consent  Exclusion Criteria:  urinary incontinence or inability to collect urine for 24 hours moderate and severe kidney insufficiency hepatic insufficiency history of hypercortisolism or adrenal insufficiency treatment interfering with the cortisol metabolism: taking oral or inhaled glucocorticoids within the last 6 months pregnant and lactating woman.