Inclusion Criteria:  Subject is ≥18 years of age Subjects with native coronary artery disease (including stable or unstable angina and silent ischemia) suitable for PCI Left ventricular ejection fraction >25% within 6 months The target lesion must be a de novo coronary lesion that has not been previously treated with any interventional procedure  LAD, RCA or LCX (or of their branches) with:  Stenosis of ≥70% and <100% or Stenosis ≥50% and <99% (visually assessed) with evidence of ischemia via positive stress test, or fractional flow reserve (FFR) value ≤0.80, or iFR <0.90 or IVUS or OCT minimum lumen area ≤4.0 mm² The lesion length must not exceed 40 mm The target vessel must have TIMI flow 3 at baseline (visually assessed; may be assessed after pre-dilatation) Evidence of calcification at the lesion site by angiography, with fluoroscopic radio-opacities noted without cardiac motion prior to contrast injection involving both sides of the arterial wall in at least one location  Exclusion Criteria:  Subject experienced an acute MI (STEMI or non-STEMI) within 30 days prior to index procedure New York Heart Association (NYHA) class III or IV heart failure Renal failure with serum creatinine >2.5 mg/dL or chronic dialysis Subjects in cardiogenic shock or with clinical evidence of acute heart failure Target lesion is located in a native vessel that can only be reached by going through a saphenous vein or arterial bypass graft Previous stent within target lesion (in-stent restenosis)