Inclusion Criteria:  Minimum age of 18 years for mother.  Non-viable fetus (missed abortion or blighted ovum) in the 1st trimester of pregnancy evidenced by criteria for diagnosis by TVS . Previous C.S or Myomectomy (1 or more ) lack of any maternal diseases such as: heart disease, asthma, history of thromboembolism, cancer, renal failure, and liver diseases.  Exclusion Criteria:  * Medical problem in patient  Emergency conditions which need intervention . History of allergy to misoprostol or letrozole drugs.