Inclusion Criteria:  Age ≥18, ≤75 years, (subject to the date of signing the informed consent) who voluntarily sign the informed consent. Positive expression of Claudin 18.2 which is defined as moderate to severe membrane staining (2+/3+) in ≥50% of tumor cells tested by central laboratory immunohistochemistry (IHC). Histologically or cytologically confirmed diagnosis of advanced or metastatic solid tumors. At least one measurable lesion as per RECIST version 1.1. Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) 0 or 1. Life expectancy ≥12 weeks. Adequate major organ function within 7 days prior to treatment. Serum pregnancy tests were negative in women of reproductive age (WOCBP) within 7 days prior to initial use of the investigational drug. Patients and their spouses must agree to take adequate contraceptive measures from the time of signing the informed consent until 6 months after the last dose. During this period, women are not breastfeeding and men avoid sperm donation.  Exclusion Criteria:  A history of other malignancies within 3 years prior to first dose, except for locally curable cancers. Patients with central nervous system metastases.  Gastrointestinal abnormalities include:  A) Pyloric obstruction or persistent recurrent vomiting (defined as ≥3 times of vomiting in 24 hours); B) There is a high risk of gastrointestinal bleeding or that there are other gastrointestinal abnormalities affecting the drug toxicity assessment determined by the investigator.  Patient with a history of serious cardiovascular disease. A history of severe autoimmune disease that the investigator judged inappropriate for inclusion. Patients with active hepatitis B or C, or active syphilis infection, or HIV positive. Patients who are known to have severe allergic reactions and/or contraindications to prescription ingredients of NPL-015 or monoclonal antibodies, or who are intolerant to combination drugs; Patients who underwent major surgery (excluding needle biopsy) within 4 weeks prior to initial use of the investigational drug, or who required elective surgery during the trial period, or who had severe unhealed wounds, traumatic ulcers, etc. Toxicity of previous antitumor therapy did not return to grade 1 or below (CTCAE V5.0), except for toxicity of alopecia and other toxicity that researchers judged to have no safety risk. Patients have previously been treated with a drug targeting Claudin18.2.  The time interval between the last anti-tumor treatment and the first use of experimental drug should meet the following requirements:  A) Received antitumor therapy such as chemotherapy, radiotherapy (except local radiation therapy for pain relief), targeted therapy, immunotherapy, and other investigational agents within 4 weeks prior to initial administration; B) Received oral fluorouracil, small-molecule targeted drugs and traditional Chinese medicine with anti-tumor indications within 2 weeks prior to initial administration.  Receiving a corticosteroid (prednisone>10 mg/ day or equivalent dose of the same kind of drug) or other immunosuppressant treatment, except for:  A) Local, ocular, intraarticular, intranasal, and inhaled glucocorticoids; B) Short-term use of glucocorticoids for prophylactic treatment (e.g. to prevent contrast allergy).  Live attenuated vaccine is received within 2 weeks prior to the first use of the investigational drug or is planned for the study period. Other conditions that the investigator considers inappropriate for participation in this clinical trial.