Inclusion Criteria:  Male or female patients aged 18 to 65 years at the screening visit and also adolescents (12-17 years) only after initial cohort of 5 adult patients have been treated for at least three days. Patients/legal guardian endpoint must be willing to provide written informed consent.  Clinical diagnosis of NS including at least 3 out of the 4 following clinical criteria;  Neonatal erythroderma Bamboo hair and/or alopecia Chronic atopy specified as food allergy, asthma, rhino conjunctivitis and/or eczema for at least 2 years Ichthyosis linearis circumflexa Patients must be willing and able to understand and can comply with study requirements, apply the medication as instructed and be able to complete the study. Absent LEKTI on immunohistochemistry of skin biopsy and/or confirmed mutation in SPINK5 gene NS involvement ≥ 20% of Body Surface Area (BSA) required at both the screening and baseline visits. Investigator Global Assessment (IGA) of two areas to be treated, score ≥3, i.e. moderate or severe for each area required. Each target area approx. 9% of BSA. i.e. equal to one arm. Female of childbearing potential must either commit true abstinence when this is in line with the preferred and usual lifestyle or use an adequate and approved method of contraception throughout the study and for 4 weeks after the last study drug application. This criterion also applies to a prepubertal female subject who begins menses during the study.  Adequate and approved methods of contraception applicable for the subject and/or her partner are defined below:  Progestogen-only oral hormonal contraception Combination of male or female condom with cap, diaphragm, or sponge with spermicide (double barrier methods) Combined (estrogen- and progestogen-containing) oral, intravaginal, or transdermal hormonal contraception Injectable or implanted hormonal contraception Intrauterine devices or intrauterine hormone-releasing system Bilateral tubal ligation or tube insert (such as the Essure system) at least 3 months before the study Vasectomy of partner at least 3 months before the study Female subjects of non-childbearing potential must meet one of the following criteria: Absence of menstrual bleeding for 1 year prior to screening without any other medical reason Documented hysterectomy, bilateral salpingectomy, or bilateral oophorectomy at least 3 months before screening  Exclusion Criteria:  Female patient who is pregnant, nursing an infant or planning a pregnancy throughout the course of the study Patient with any uncontrolled systemic disease. A potential patient in whom therapy for a systemic disease is not yet stabile for at least 3 months will not be considered for entry into the study. Patient with positive serology tests like HIV, HCV & HBsAg. Patient with presence of any skin disease that might interfere with the diagnosis or evaluation of the test medications. Cutaneous infection within 1 week before the baseline visit or, any infection requiring treatment with oral or parenteral antibiotics, antivirals, antiparasitics, or antifungals within 2 weeks before the baseline visit. Patient that has a condition or is in a situation, which in the investigator's opinion may put the patient at significant risk, may confound the study results, or may interfere significantly with the patient's participation in the study. Use of topical drugs that might alter the course of NS (e.g., topical corticosteroids and topical calcineurin inhibitors) within two weeks before baseline visit. Patient with a known sensitivity to any of the study treatments and/or their components. Patient who anticipates a need to use other topical or systemic therapy that might alter the course of NS. Emollients/creams can be used on remaining skin area but not the test areas. Use of topical prescription treatment within 2 weeks prior to initial dosing of study drug. Recent systemic treatment for NS (e.g. systemic corticosteroids, antibiotics, immunosuppressant, biologic and biosimilars treatments). A washout period of 4 weeks will be required for such patients to be eligible to participate in the trial. Patient who anticipates the need for surgery or hospitalization during the study. Concurrent involvement in any other clinical study/expanded access program with an investigational drug or device, or participation in a clinical study within 30 days prior to entering the study. Suspected or confirmed COVID-19 infection within 4 weeks before the screening or baseline visit. Unresolved COVID-19 infection. Planned vaccination for COVID-19 during screening, treatment period or before the follow-up visit.