Inclusion Criteria:  Had the history of sexual life. Transferred to colposcopy examination and biopsy for abnormal screening of cervical cancer, contact bleeding of cervix, recurrent discomfort of vulva or abnormal signs of lower genital and anal tract. The pathology of biopsy indicate CIN, VaIN, VIN, AIN, or PaIN. If CIN, the colposcopy manifests transformation zone-1 which means the lesion can totally be seen. However the consideration of fertility damage of resection overweighs the chance of suffering cancer. The patients can accept multiple laser ablations and colposcopy examinations and follow-up at least 2 years.  Exclusion Criteria:  Patients who are suffering cancers of other systems and in treatment. Patients suffering acute inflammation of lower genital and anal tracts. The colposcopy and pathology examination suspect of cancer of lower genital and anal tract. Patients suffering severe diseases such as insufficiency of liver and kidney function, diseases of blood system and other acute infections who will get heath harm from colposcopy and laser vaporization.