Inclusion  Male and female supposed-healthy volunteer outpatients, age: > 50 years. Diagnosis: patients with chronically UV-exposed photodamaged facial skin. Consent by signing the ICF (Informed Consent Form)  Exclusion  Current participation in another clinical trial Patients who are using topical glucocorticoids on the face. Known intolerance/hypersensitivity to imiquimod Pregnant/breastfeeding women Systemic disease, immunodeficiency