Inclusion Criteria:  Patients must be between 0 to 21 years old with Sickle Cell Disease and receive care at the Riley Hospital for Children Comprehensive Sickle Cell Disease clinic. The family must be willing to receive their care using the telemedicine model available to them based on the location of their primary residence. TeleSCD model participants must live within 1 hour of the pre-identified telemedicine sites, while VirtualSCD model participants must live within the city limits of the pre-identified area.  Exclusion Criteria:  If a patient receives chronic transfusion therapy, they will not be eligible to participate, as our telemedicine models will not support this.