Inclusion Criterion:  • Asymptomatic moderate aortic valve stenosis on recent (<6 months) echocardiography (based on peak velocity, mean gradient, aortic valve area). The severity of AS will be quantified according to current EACVI / ASE guidelines.  Exclusion Criteria:  Heavily calcified aortic valve on echocardiography (defined as grade 4 calcification: extensive thickening/calcification of all cusps as described in the articles by Rosenhek et al.); a planned aortic valve replacement in the next six months; severe mitral valve stenosis (MVA < 1cm2); severe mitral or aortic valve regurgitation; rheumatic aortic valve disease; bicuspid aortic valve; valvular disease due to history of chest radiation; left ventricular dysfunction (LVEF < 35%); renal impairment (eGFR <30 ml/min/1.73m2); patients aged <50 and >80 years; pre-existing chronic gastro-intestinal complaints which may obscure signs of colchicine intolerance; child-bearing potential without the use of contraception; use of CYP3A4 (e.g. verapamil) or P-glycoprotein inhibitors; use of bisphosphonate or denosumab; chronic use of immunosuppressants or anti-inflammatory drugs including colchicine and NSAID's (excl. acetylsalicylic acid); active or chronic liver disease; the presence of a pacemaker or internal cardiac defibrillator; life expectancy <2 years.