Inclusion Criteria:  Subjects eligible for inclusion in the study must meet all of the following criteria:  Signed the informed consent; Have pain-related TMD myalgia assessed by history and clinical examination as established by the DC/TMD; Age 18 years and younger than 60 years; Have a good knowledge of the English language; Able to understand and comply with the study requirements; Have had TMD myalgia for 6 months or longer; and If taking pain medications, the dose regimen must be stable for at least 4 weeks prior to the screening visit.  Exclusion Criteria:  Subjects meeting any of the following criteria are not eligible for inclusion:  Lacking stable bilateral posterior occlusion; Currently uses a complete maxillary or mandibular prosthetic denture; Currently pregnant or plan to become pregnant; Breastfeeding or plan to breastfeed; Allergic to erenumab-aooe or any of the ingredients in Aimovig® (acetate, polysorbate 80, and sucrose); Allergic to rubber or latex; Currently undergoing TMD treatment elsewhere; Currently undergoing orthodontic treatment; Currently included in other experimental protocols within the last 30 days before enrollment; Having 11 or more headaches during the past 4 weeks; Having received massage, acupuncture or physical therapy treatment of the head, neck or shoulders during the previous 3 months; History of unstable or acute severe pain from another pain condition; History of traumatic brain injury; History of surgical treatment or recommended surgical treatment for TMD; History of ongoing, unresolved disability litigation; History of drug abuse; History of moderate to severe sleep apnea requiring CPAP or oral mandibular repositioning appliance; Anything that would place the subjects at increased risk or preclude the individual's full compliance with or completion of the study (e.g., medical condition, laboratory finding, physical exam finding logistical complication); and History of previously receiving erenumab-aooe or other anti-CGRP therapies, including anti-CGRP and anti-CGRP receptor monoclonal antibodies and small molecule CGRP receptor antagonists (gepants). History of chronic constipation and/or using medication associated with decreased gastrointestinal motility. History of hypertension or risk factors for hypertension.