Inclusion Criteria:  >= 18 years of age cancer patients treated with ICI therapy (e.g., anti-CTLA-4, anti-PD-1, anti-PD-L1, and combinations) patients with primary autoimmune or autoinflammatory diseases that resemble immune-related adverse events (irAEs) healthy volunteers with non-inflammatory disorders, and without any history of cancer  Exclusion Criteria:  Participants not able to provide informed consent