Inclusion Criteria:  Medically stable adult patients between 35 and 60 years of age with moderate to severe OSA (AHI>15 events/hour by a full night in-laboratory polysomnogram or ambulatory study) More than 9 minutes/night spent below oxygen saturation of 90%. Subjects who have declined therapy, or who have not adhered to CPAP therapy for at least one month prior to the study recruitment .  Exclusion Criteria:  Subjects who have excessive daytime sleepiness (Epworth Sleepiness Scale > 12/24) Subjects who have documented CVD Subjects who have severe sleep associated desaturation (>30% of the sleep study with oxygen saturation <88%). Subjects who are on active therapy for OSA or recently treated for OSA with CPAP in the previous month. Subjects who have a chronic inflammatory disease (e.g. rheumatoid arthritis, asthma) Subjects who regularly use of anti-inflammatory drugs (i.e. systemic or inhaled corticosteroids, statin, ACEI), or other immunosuppressive drugs. Subjects who are taking antioxidants. Subjects who have diabetes. Subjects who have autoimmune syndrome.