Inclusion Criteria:  Participant has an index VOC. The index VOC is any VOC that required admission to a healthcare facility and treatment with parenteral pain medication. An admission for the index VOC includes:  A hospital admission, or An admission to an emergency room, observation unit, or infusion center for ≥ 12 hours, or 2 visits to an emergency room, observation unit, or infusion center over a 72-hour period  for an acute episode of pain with no other cause other than a vaso- occlusive event that includes the following:  Uncomplicated VOC, Acute chest syndrome (ACS), Acute hepatic sequestration, Acute splenic sequestration, or Priapism. Participant has a confirmed diagnosis of SCD (any genotype). Documentation of SCD genotype is required and may be based on documented history of laboratory testing or confirmed by laboratory testing at Baseline. Participant is male or female, ≥ 12 years of age at the time of informed consent.  Participant has experienced between 2 and 10 VOCs within the 12 months prior to Screening as determined by documented medical history. The index VOC is not to be considered as one of the 2 to 10 events. A prior VOC is defined as an acute episode of pain that:  Has no medically determined cause other than a vaso-occlusive event, and Results in a visit to a healthcare facility (hospital, emergency department, urgent care center, outpatient clinic, or infusion center) or results in a remote contact with a healthcare provider; and Requires parenteral narcotic agents, parenteral nonsteroidal anti-inflammatory drugs (NSAIDs), or an increase in treatment with oral narcotics. Participants receiving erythropoiesis-stimulating agents (ESA, e.g., erythropoietin [EPO]) must be on a stable dose for at least 90 days prior to Screening and expected to continue with the stabilized regimen throughout the course of the study. Participants receiving hydroxyurea (HU), L-glutamine, or voxelotor (Oxbryta®) must be on a stable dose for at least 30 days prior to Screening and expected to continue with the stabilized regimen throughout the course of the study.  Exclusion Criteria:  Participant is receiving regularly scheduled red blood cell (RBC) transfusion therapy (also termed chronic, prophylactic, or preventative transfusion). Participant is taking or has received crizanlizumab (ADAKVEO®) within 90 days prior to Screening. Participant weighs > 133 kg (292 lbs.).  Other protocol-defined Inclusion/Exclusion may apply.