Inclusion Criteria:  Patients with clinically confirmed hemophilia A (coagulation factor VIII <1%) and previous medical records confirming exposure to coagulation factor VIII for ≥150 days (EDs ≥150). Non-immunodeficient, with some immunity (CD4 > 200/μL). Platelet count >100×10^9/L. Normal prothrombin time (PT) or international normalized ratio (INR) <1.3. Negative lupus anticoagulant. Fully understand, informed about this study and sign the informed consent form, voluntarily participate in the clinical study and have the ability to complete all study procedures  Exclusion Criteria:  Hypersensitivity to the test substance or its excipients (including rodent or hamster protein). Pre-existing hypersensitivity or allergic reactions to FVIII or IgG2 injection therapy. Positive FVIII inhibitor at screening (≥0.6 BU/mL), or previous history of FVIII inhibitor Positive history, or family history of inhibitors. Patients with other coagulation disorders in addition to hemophilia A. The results of vWF antigen examination lower than normal. Severe anemia and need blood transfusion (hemoglobin < 60g/L). Patients who have received any standard half-lives FVIII formulations (e.g., Kogenate, Kovaltry, Advate, Xyntha, etc.) or received any other half-life-extending FVIII formulations within 4 days or 5 half-lives (whichever is longer) before administration. Patients who had used emecizumab within 6 months prior to administration. Patients with fever, upper respiratory tract infection or allergy symptoms within the previous 2 weeks before screening. Suffer from other diseases that may increase the risk of bleeding or the risk of thrombosis. Severe cardiovascular and cerebrovascular diseases: such as cerebral hemorrhage, stroke, myocardial infarction, unstable angina pectoris, congestive heart failure(the current New York Heart Association cardiac function grade III, Hypertension that cannot be controlled with drug treatment: systolic blood pressure> 160 mmHg or diastolic blood pressure> 95 mmHg. Clinically significant of other systematic diseases: alcoholism, drug abuse, mental disorders and mental retardation. Significant hepatic or renal impairment (ALT and AST > 2×ULN; serum bilirubin level > 3 × upper limit of normal (ULN)). Abnormal kidney function: BUN > 2×ULN, Cr > 2.0mg/dL. One or more clinically significant tests for Hepatitis B Virus Surface Antigen, Human Immunodeficiency Virus (HIV), Antisyphilitic spirulina (TPHA) and Hepatitis C Virus (HCV) Antibody. Patients who received any anticoagulant or antiplatelet therapy within a week prior screening or need to receive an anticoagulant or antiplatelet therapy during the period of clinical trials. Systemic immunomodulators (e.g., corticosteroids [equivalent dose of 10 mg/ day prednisone], A-interferon, immunoglobulin, cyclophosphamide, cyclosporine, etc.) were used within 14 days prior to administration or during the study period. Patients having major surgery or receiving blood or blood components transfusion within 4 weeks prior screening or having planned major surgery schedule during the study. Patients who previously participated in the other clinical trials within a month prior screening. Any life-threatening disease or condition which, according to the investigator's judgment, could not benefit from the trial participation. Patient who is considered by the other investigators not suitable for clinical study.