Inclusion Criteria:  Males and females ≥ 18 years of age Willing to sign the informed consent and deemed capable of following the study protocol Subjects must have a diagnosis of primary or secondary unilateral upper extremity edema  Exclusion Criteria:  Individuals with a history or presence of a systemic disorder or condition that could place the subject at increased risk from sequential compression therapy Inability or unwillingness to participate in all aspects of study protocol and/or inability to provide informed consent Subjects with exam results that would prevent safe and effective use of the study device (cellulitis, open-wounds, healing-wounds, etc.) Subjects must not have any diagnosed cognitive or physical impairment that would interfere with use of the device Diagnosis of lipedema Diagnosis of active or recurrent cancer (< 3 months since completion of chemotherapy, radiation therapy or primary surgery for the cancer) Diagnosis of Acute infection (in the last four weeks) Diagnosis of acute thrombophlebitis (in last 6 months) Diagnosis of pulmonary embolism or deep vein thrombosis within the previous 6 months Diagnosis of pulmonary edema Diagnosis of congestive heart failure (uncontrolled) Diagnosis of chronic kidney disease with renal failure Diagnosis of epilepsy Subjects with poorly controlled asthma Any condition where increased venous and lymphatic return is undesirable Women who are pregnant, planning a pregnancy or nursing at study entry Participation in any clinical trial of an investigational substance or device during the past 30 days