Inclusion Criteria:  All of the following:  The patient must be ≥18 years of age  Patients with an indication for PCI of at least one lesion satisfying any of the following criteria:  Angiographic heavy calcification Ostial lesions True bifurcation lesions involving side-branches >2.5mm Left main lesions Chronic total occlusion In-stent restenosis Long-lesions (estimated stent length > 28mm) OR Patient with an indication for PCI for any lesion and in need for elective mechanical circulatory support assisted PCI Presenting with silent ischemia, stable angina, unstable angina or non-ST-elevation acute coronary syndrome (NSTE-ACS) All lesions must be suitable for treatment with the Synergy stent system, Synergy Megatron system, or other Synergy platform iteration The patient is willing and able to cooperate with study procedures and follow-up until study completion Subject is able to confirm understanding of risks, benefits and treatment alternatives and he/she provides informed consent prior to any protocol-related procedure, as approved by the appropriate Ethics Committee  Exclusion Criteria:  Any of the following:  ST-elevation myocardial infarction, cardiogenic shock Known untreated severe valvular heart disease IVUS is strictly required for pre-PCI lesion severity assessment Known contraindication or hypersensitivity to everolimus, platinum-chromium, or to anticoagulants Absolute contraindications or allergy that cannot be pre-medicated, to iodinated contrast or to antiplatelet drugs, including both aspirin and P2Y12 inhibitors Non-cardiac co-morbidities with a life expectancy less than 1 year Currently participating in another trial that is not yet at its primary endpoint. The patient is not allowed to participate in another investigational device or drug study until the trial primary endpoint time point is achieved and may only be enrolled once in the study Women of childbearing potential who do not have a negative pregnancy test within 7 days before the procedure and women who are breastfeeding Subject belongs to a vulnerable population (per investigator's judgment) or subject unable to read or write