Inclusion Criteria:  Male or female, age above or equal to 18 years at the time of signing informed consent Body Mass Index (BMI) equal to or greater than 30.0 kg/m^2 Clinical diagnosis of knee OA (American College of Rheumatology (ACR) criteria) with moderate radiographic changes (Kellgren-Lawrence (KL) grades 2 or 3 as per central reading) in target knee. Target knee joint is defined as most symptomatic knee at screening. If pain in knees are equal target knee joint will be in the most dominant leg. Pain due to knee OA  Exclusion Criteria:  Joint replacement in target knee Arthroscopy or injections into target knee within last 3 months prior to enrolment Any other joint disease in the target knee