Inclusion Criteria:  Between 18 to 65 years of age for men and 18-75 for women, inclusive, at the Screening Visit. Mean AHI 10 to 45 events/h, inclusive PGI-S: >1  Exclusion Criteria:  Current clinically significant sleep disorder other than OSA Clinically significant craniofacial malformation. Clinically significant cardiac disease (e.g. rhythm disturbances, coronary artery disease or heart failure or hypertension requiring more than 2 medications for control). Participants with a history of using devices for OSA treatment, including CPAP, oral or nasal devices, or positional devices, may enroll as long as the devices have not been used for at least 2 weeks prior to first PSG and are not used during participation in the study