Inclusion Criteria:  18-65 years of age at screening Met the American College of Rheumatology criteria (2010) for RA Active mild to moderate RA (defined as 3.2 < DAS28-CRP< 5.1) naïve to any medication; or refractory RA who demonstrated an inadequate response or loss of response to 2 or more conventional synthetic Disease-Modifying Anti-Rheumatic Drugs (csDMARDs) after treatment for at least 6 months.  Exclusion Criteria:  Any severe chronic or uncontrolled comorbid disease, such as important organ failure, degree II and III heart block, clinically significant cardiovascular disease, severe infection, tumor, etc; Combined with other connective tissue diseases Cognitive impairment and can't cooperate Pregnancy or breastfeeding Bleeding or coagulation disorders Localized skin infections Intra-articular corticosteroid or pulse steroid within 2 weeks preceding the study