Inclusion Criteria:  Age 18 years or older Male or a nonpregnant female All of the following: Established diagnosis of amyloid TTR Cardiomyopathy; baseline ejection fraction ≥25% and ≤45%; at least one hospitalization due to worsening heart failure over the year before entry into the registry. ICD if indicated PM if indicated Willing and able to return for all follow-up visits  Exclusion Criteria:  AL amyloid cardiomyopathy Subjects who have a potentially correctible cause of heart failure (eg, Ischemic or valvular or congenital heart disease). Scheduled for CABG or PCI or has undergone a CABG within 90 d or PCI within 30 d. Myocardial infarction within 90 days Mechanical tricuspid valve Prior heart transplant Chronic haemodialysis Familial TTR amyloidotic cardiomyopathy with significant polyneuropathy potentially eligible for Patirisan or Inotersen17 Unable to provide informed consent