Inclusion Criteria:  The subjects can communicate well with the researchers, understand and comply with the requirements of this study, and sign the informed consent voluntarily. Age on the day of signing the informed consent: healthy subjects aged 18 or above, both male and female. At the time of screening, male weight ≥ 50.0 kg, female weight ≥ 45.0 kg, 19.0 kg / m2 ≤ BMI ≤ 26.0 kg / m2. Fasting blood glucose ≥ 3.9 mmol / L and < 6.1 mmol / L. From one month before the informed consent to three months after the last medication, the subjects and their partners had no plans to have a child, take effective contraceptive measures voluntarily, and donate sperm or eggs.  Exclusion Criteria:  Within 3 months before screening, a clinical trial was completed or withdrawn, or a clinical trial was currently in progress, or other medical trials were conducted. The researchers judged that it was not suitable for the trial. In the past, there were serious systematic diseases or family history (including cardiovascular system, digestive system, urinary system, etc.), the researchers judged that the disease status could significantly change the absorption, distribution, metabolism and excretion of the drug used in the trial, or the risk of the subjects would be increased by taking the trial drug. Allergic constitution, or food allergy history, or known to be allergic to study drug / similar drug. Previous history of hypoglycemia. Previous patients with postural hypotension. The past five years have been positive for drug abuse, drug use history or urine drug screening results. Those who donate blood or lose more than 400ml of blood within 4 weeks before screening, or who have received blood or blood component infusion within 4 weeks before screening, or who plan to donate blood components within 3 months after the end of the study. Those who have history of syncope or blood sickness, who cannot tolerate venous puncture or have difficulty in blood collection. Severe infection, trauma or surgical operation within 4 weeks prior to screening, or those who are scheduled to perform surgery during the study (including, but not limited to, dental operations). Use any prescription, over-the-counter, herbal or health care product within 2 weeks prior to screening. Any drugs that inhibit or induce the metabolism of liver drugs were used within 30 days before screening. The average alcohol intake in the first three months of screening was more than 14 units per week (1 unit = 360ml beer, 45ml of alcohol content of 40% spirits or wine 150ml), or those who could not give up drinking alcohol during the test, or those who were positive for alcohol exhalation. Smoking was ≥ 5 cigarettes per day within 3 months before screening, or unwilling / unable to give up smoking during the trial. Special requirements for diet, and those who cannot comply with the unified diet arrangement. No guarantee of chocolate, any caffeine or food or drink (such as Firedragon fruit, grapefruit, grapefruit, orange juice, mango, etc.) 48 hours before and during the test. Pregnant or lactating women, or pregnant women with positive results. The results of screening were positive for HBsAg, HCV, TP and HIV. ALT > 1.5 times of normal value was found in screening（ × ULN), or glutamic transaminase (AST) >1.5 × ULN, or serum total bilirubin (TBIL) > 1.5 × ULN。 The results of 12 lead ECG were: QT interval (qtcb) >450ms (male) or >470ms (female). The results of physical examination, vital signs, abdominal B-ultrasound (liver, gallbladder, pancreas, spleen and kidney), chest CT, ECG, laboratory examination items and related auxiliary examination results were judged by the researchers to be unsuitable for the participants. The researchers judged that the subjects with other factors were not suitable for participating in the test.