Inclusion Criteria:  Patients 18 years or older. Signature of the form consent for participation in the study. Diagnosis of APL (either primary or secondary) according to the criteria of the World Health Organization (WHO), without prior treatment. Identification of the specific genetic alteration of APL by conventional karyotype, fluorescent in situ hybridization (FISH), reverse transcriptase polymerase chain reaction (RT-PCR or RQ-PCR). Identification of the transcript is recommended at the time of diagnosis isoforms: bcr1, bcr2, bcr3 essential to document the therapeutic response: Molecular remission  Exclusion Criteria:  Presence of other concomitant active malignant tumors that require simultaneous treatment. Having received prior treatment for APL.  Electrocardiogram abnormalities:  Patients with a pre-existing diagnosis of Long QT Syndrome Patients with a baseline QTc of> 450msec. The Bazett formula should be used to measure the corrected QT interval (QT interval in msec divided by the square root of the RR interval in msec). Patients with a history or presence of significant ventricular or atrial tachyarrhythmia (Grade 3-4, CTCAE v5.2017). Patients with right bundle branch block plus left anterior hemiblock. Bifascicular blocks are excluded. ECOG score 4. Stage III-IV heart failure. Serum creatinine ≥ 2.5 mg / dL (≥ 250 μmol / L) unless due to APL. Bilirubin ≥ 2.5 mg / dL, alkaline phosphatase, GPT or GOT> 3 times the normal limit unless it is for APL. Severe psychiatric illness. Women who are pregnant or who have decided to continue breastfeeding.