Inclusion Criteria:  age between 18 and 80 years old mild to moderate degenerative temporomandibular joint disease based on DC/TMD protocol and MRI/CT agreement to take part in the study  Exclusion Criteria:  severe hematologic and/or neurological disorder rheumatoid arthritis septic arthritis polymyalgia rheumatica gout Paget's disease osteonecrosis connective tissue disease malignant disease vasculitis any previous temporomandibular joint (TMJ) invasive treatment any current temporomandibular joint (TMJ) conservative or invasive treatment patients who had used oral, parenteral or intra-articular corticosteroids in the 3 months prior to the first injection previous or current radiotherapy of head and neck pregnancy or lactation presence of severe mental disorders drug and/or alcohol addiction presence of local contraindications for injection therapy patients with needle phobia presence of hypersensitivity to substances to be used in the study