Inclusion Criteria:  have read the subject information and signed informed consent documents age 18 - 55 years body mass index between 18-25 kg/m2 have a normal electrocardiogram blood pressure within normal range (systolic 90-120 mmHg and diastolic 60-80 mmHg) heart rate within normal range (60-100 bpm) with absence of significant disease or clinically significant abnormal laboratory values on laboratory evaluation, medical history or physical examination during screening acceptance to use protection (condom) during intercourse with their spouse throughout the study  Exclusion Criteria:  those who are pregnant and/or nursing women those with a history of hypersensitivity to furosemide, or other diuretics or other ingredients in the drugs or a history of serious allergic reaction to any drug, a significant allergic disease, or allergic reaction those with a history or presence of medical condition which might significantly influence the pharmacokinetic of the study drug, e.g. chronic gastrointestinal disease, diarrhea, gastric surgery, renal insufficiency, hepatic dysfunction or cardiovascular disease. those with a history or presence of any coagulation disorder or clinically significant hematology abnormalities those who are using any medication (prescription or non-prescription drug, food supplement, herbal medicine), particularly the medication known to affect the pharmacokinetic of the study drug, within one week prior to the drug administration day those who have participated in any clinical study within 3 months prior to the study (< 90 days) those who have donated or lost 300 ml (or more) of blood within 3 months prior to the study those who smoke more than 10 cigarettes a day those who are positive to HIV, HBsAg, and HCV tests (to be kept confidential) those with a history of drug or alcohol abuse within 12 months prior to screening for this study those who are unlikely to comply with the protocol, e.g uncooperative attitude, inability to return for follow up visits, poor venous access