Inclusion Criteria:  Age above 18 up to 65 years Microbiologically or histologically confirmed active tuberculosis as well as confirmed positive with COVID-19 Clinically confirmed latent tuberculosis Drug resistant MTb Negative pregnancy test for 18-40 year-old females Able to sign consent  Exclusion Criteria:  HIV positive Known intolerance of vitamin D Sarcoidosis Hyperparathyroidism or nephrolithiasis Taking vitamin D or A supplementation in the two months preceding enrolment Baseline serum corrected calcium >2.65 mmol/L Current haemodialysis Children, pregnant or breastfeeding individuals Concomitant benzothiadiazine derivative, cardiac glycoside, carbamazepine, phenobarbital, phenytoin, primidone or long-term immunosuppressant therap Extra-pulmonary or smear negative tuberculosis Patients receiving steroids, cytotoxic drugs, post transplant or metastatic malignancy, or not expected to survive for the duration of ATT Pregnant or lactating women Active diarrhoea, indicating possible fat-soluble vitamin malabsorption. Baseline Hypercalcemia >10.5 mg/dl Concurrent use of cyclosporin, cisplatin, amfotericin B, cephalosporins, polymyxins and vancomycin. History of adverse events on previous Minocycline or other tetracycline use (by spontaneous reporting nor by active questioning). Depressive disorder Body mass index less than 18 points or higher than 25 points Contraindications for hormonal contraception or intrauterine device. Autoimmune diseases A history of organ, bone marrow or hematopoietic stem cell transplantation Patients receiving anti-hcv treatment Permanent blindness in one eye History of iritis, endophthalmitis, scleral inflammation or retinitis 15-90 days of retinal detachment or eye surgery