Inclusion Criteria:  Ability to walk without support. Life expectancy greater than 7 days Previous authorization of treating hematologist for participation Acceptance and signing of informed consent form  Exclusion Criteria:  Patients with neutropenia, infections and / or bleeding on admission to hospitalization. Patients that are unable to perform physical activity. Central nervous system diseases that make movement impossible. Cardiac function alterations assessed by electrocardiogram and echocardiogram Patients in relapse Patients referred from another hospital and who are been attended in our hospital