Inclusion Criteria:  Male or female 21 years or above age. 2 or 3 of the 5-point (0-4) NLFRS (Nasolabial Fold Rating Scale). Agree to use proper contraception as guided in the protocol. Signed for Informed Consent.  Exclusion Criteria:  have received permanent facial implants anywhere in the face or neck or planning during the investigation. have undergone facial plastic surgery of the lower face and nasolabial region within 12 weeks have undergone semi-permanent filler in lower face have undergone temporary dermal filler treatment in the lower two-thirds of face within 12 months Have undergone facial tissue augmentation or facial treatment with fat or botulinum injections in the lower two-thirds of face Have undergone mesotherapy or cosmetic procedures in face or neck within 6 months have used any over-the-counter anti-wrinkle products or prescription anti-wrinkle medicines for the nasolabial folds within 28 days