Inclusion Criteria:  patients suffering from Diabetes Mellitus Type 1 adult patients patients who agreed to participate to the study and that signed the informed consent.  Exclusion Criteria:  patients taking intravenous or oral Bisphosphonates at the study begin or in the previous 12 months patients with low compliance and motivation to participate pazienti irradiati alla testa o collo negli ultimi 12 mesi pregnant or breastfeeding women alcohol and drug abuse patients with psychiatric diseases