Inclusion Criteria:  Patients who are overtly healthy as determined by medical evaluation including lack of diagnosis of Down Syndrome and children with Down Syndrome  Exclusion Criteria:  Contraindication to adhesive placement, eg, epidermolysis bullosa Patient or parent refusal Opioids Heart rate altering therapy such as beta blockers During the study period, participants will abstain from ingesting caffeine- or xanthine-containing products (eg, coffee, tea, cola drinks, and chocolate) for [6 hours] before the start of the anesthetic. Participants will be assumed not to be using tobacco or alcohol during the study period due to their young age.