Inclusion Criteria:  Man or woman aged ≥18 and <90 years old; Must not be of child-bearing potential (≥1 year post-menopausal, contraceptive, or surgically sterile); Symptoms suggestive of CCS and intermediate PTP (15-85%) according to the Diamond classification (2); Undergone at least one stress imaging test (annex 3) or an abnormal coronary Computed Tomography Angiography (CTA) with the recommendation to perform ICA with FFR in all intermediate lesions; Non-contributive ECG (resting 18-lead); Normal echocardiography with left ventricular ejection fraction (LVEF) >50%; Cardiac troponin level <99th percentile; Intended for an invasive strategy for CCS; Affiliated to or beneficiary of, a social security system; Signed written informed consent.  Exclusion Criteria:  Persons referred in articles L.1121-5 to L.1121-8 and L.1122-2 of the Public Health Code:  Pregnant, parturient or breastfeeding woman Person deprived of liberty for judicial or administrative decision Person under psychiatric care  Minor person (non-emancipated)  History of CAD or known CAD Suspected acute coronary syndrome (ACS: annex 4) Inability to undergo adenosine testing Allergy to iodinated contrast media Bleeding diathesis Known significant bleeding risk according to physician judgment Severe hepatic failure (ASAT, ALAT>3ULN) Ischemic stroke within 1 month or a history of hemorrhagic stroke Bradycardia Platelet count <100 G/L Hemoglobin <10g/dl Major surgery or trauma within 10 days Life expectancy <1 year Pre-test Probability <15% or >85% History and clinical examination suggesting non-cardiac chest pain Contraindication to coronary angiography Thyroid disorder Refusal to participate