Inclusion Criteria:  Smoke ≥5 cigarettes per day for past year ≥21 years old Able to read and write English Desire to quit smoking Not currently engaged in cessation treatment Eligible to use combination nicotine replacement therapy Willing and able to attend study visits Have reliable smartphone access Not currently pregnant, trying to get pregnant, or breastfeeding Willing to respond to ecological momentary assessment prompts and other study activities Baseline breath carbon monoxide (CO) ≥5ppm  Exclusion Criteria:  Used pipe tobacco, cigars, snuff, or chew more than twice in the past week Used e-cigarette, vaping, or any other electronic nicotine delivery product more than twice in the past week Unwilling to try to abstain from all non-medicinal nicotine use (including e-cigarettes) for the duration of the Cessation Phase (other than nicotine replacement therapy provided by the study) Currently taking varenicline or bupropion Allergy to adhesive tape Previous reaction to the nicotine patch or mini-lozenge that prevented them from continuing to use it Unwilling to use study approved methods of birth control while taking study medication and for 1 month after discontinuing study medication [only for women of child-bearing potential] Hospitalized for a stroke, heart attack, congestive heart failure, ulcers, or diabetes within the last year History of seizure within the last year Diagnosis of and/or treatment for schizophrenia, other psychotic disorders, or bipolar disorder within the last 5 years End-stage renal disease Suicide attempt or suicidal ideation within the last 12 months Severe hypertension > 180/100 mmHg