Inclusion Criteria:  Patients that are seen at MD Anderson Cancer Center Patients with pancreatic ductal adenocarcinoma (PDAC) diagnosis who are expected to have surgery (whipple) Patient should have normal levels of blood cell count (CBC) differential and CBC chemistry test results White blood cell (WBC) count >= 3,000/microL Platelet count >= 75,000/microL Hemoglobin (Hgb) >= 8 g/dL Total bilirubin level =< 1.5 x the upper limit of normal (ULN) An aspartate aminotransferase (AST) level =< 2.5 x ULN An alanine aminotransferase (ALT) level =< 2.5 x ULN Estimated creatinine clearance > 30 mL/min according to the Cockcroft-Gault formula or by a creatinine clearance measurement from a 24-hour urine collection Between ages 18-70 Male or female Willingness and ability to sign an informed consent Consent and ability to give blood and stool samples Consent to undergo a baseline core biopsy and colonoscopy for FMT delivery An Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2  Exclusion Criteria:  Age younger than 18 years Positive gastrointestinal (GI) infection Patients with pancreatic cancer stage T1N0 Individuals at higher risk of colonization with multi-drug resistant organisms (MDROs) Patient received antibiotics in the last 48 hours. Patients will be eligible to enroll if antibiotic therapy is discontinued for at minimum 48 hours prior to start of study Patients with active viral, bacterial or fungal infection History of inflammatory bowel disease, and/or radiation enteritis or colitis Pregnant and breastfeeding women Women of child-bearing potential who have positive urine or serum pregnancy test or refuse to do pregnancy test Has a diagnosis of immunodeficiency Peripheral WBC > 12 x 10^9/L and/or temperature > 38 degrees Celsius Subjects with neutropenia (absolute neutrophil count [ANC] < 1500) Swallowing dysfunction or known chronic aspiration Delayed gastric emptying History of intestinal obstruction Acute exacerbation of underlying comorbid condition Severely immunocompromised patients Allergies to ingredients generally recognized as safe