Inclusion Criteria:  Age between 25 and 75 years-old Diagnosis of pre-existing osteoarthritis of the glenohumeral joint Working understanding of the English language and able to fully understand the procedure Capable of providing informed consent Able to complete online, in-person or phone surveys for the purposes of follow-up Capable of understanding pre- and post-procedure care instructions Ambulatory at baseline Previous trial and failure of conservative therapy consisting of a minimum of 6 weeks of physical therapy and trial of anti-inflammatory medications if not contraindicated, with or without concomitant bracing and/or injections.  Exclusion Criteria:  Age < 25 or > 75 years old Radiographs demonstrating either no, little osteoarthritis, severe(bone on bone) osteoarthritis Prior total or partial joint replacement surgery or surgery involving cartilage regeneration Previous cortisone, PRP or Hyaluronic acid intra-articular injection within the last 3 months Co-morbidity with the rheumatologic condition, inflammatory arthritis Currently undergoing immunomodulatory therapy Uncontrolled endocrine disorder BMI >40 or joint space not visible by ultrasound Current diagnosis of osteomyelitis, human immunodeficiency virus (HIV-1, -2) and/or hepatitis C (HCV), infection, and poorly controlled diabetes (HgA1C >7.0) Pregnancy or planned pregnancy previous stem cell injection into treatment joint Patient scheduled to undergo any concomitant shoulder surgical procedures or other surgery which may affect outcomes. Coagulopathy or anticoagulant treatment Chronic pain involving multiple body parts or opioid medication management Diagnosis of fibromyalgia Concomitant massive(2 tendons with retraction), complete rotator cuff tendon tear