Inclusion Criteria:  Helicobacter pylori infected patients comfirmed by 13C/14C UBT age 18~65  Exclusion Criteria:  prior Hp eradication therapy including amoxicillin and clarithromycin previous gastric resection allergic to the drugs used in this study previous use of proton pump inhibitors, bismuth, H2 receptor antagonist or antibiotics, probiotics within 4 weeks of the study Patients who were pregnant or lactating Patients taking NSAIDs, alcoholic or with other serious disease (e.g. hepatopathy, heart disease, nephropathy#diabete mellitus, hypertension…) effect the evaluation of this study Can't express the complaint correctly