Inclusion Criteria:  Dry eye disease for > 3 months meeting specific sign and symptom criteria Best corrected visual acuity of +0.6 logMAR or better Willing to sign informed consent and attend study visits Willing to comply with contraception requirements  Exclusion Criteria:  Unable to meet specific sign and symptom criteria Signs of ophthalmic allergic, inflammatory or infection conditions Use of contact lenses Anatomic abnormalities preventing accurate study assessments Use of medications that influence eye dryness Recent ophthalmic surgery Unwilling to suspend current treatments for dry eye disease