Inclusion Criteria:  Patients undertaking systemic cisplatin therapy as part of their cancer treatment Age ≥ 18 Willing to provide informed consent ECOG performance status 0-2 For female of child-bearing potential, a negative pregnancy test (beta-HCG) prior to study treatment is required Any patient who is of reproductive age should provide written agreement to use adequate contraception for the duration of the trial  Exclusion Criteria:  Age less than 18 Preexisting severe to profound sensorineural hearing loss (unilateral or bilateral) (speech reception threshold >70dB, or word recognition score <50%) as confirmed with an audiogram History of Meniere's or fluctuating hearing loss Asymmetrical hearing loss (bone conduction threshold difference of: (a) 20 dB threshold difference at a single frequency, (b) 15 dB threshold difference at 2 frequencies, (c) 10 dB threshold difference at 3 frequencies Abnormal renal function (creatinine clearance <60 ml/min) Abnormal liver function (liver function tests (ALT and ALP) >2.5 times upper limit of normal without liver metastasis and >5 times upper limit of normal with liver metastasis Previous hypersensitivity to STS or mannitol Pregnant and/or nursing women Patient unable to follow the protocol for any reason