Inclusion Criteria:  Provision of signed and dated informed consent form  Stated willingness to comply with all study procedures and availability for the duration of the study  Male or female, ages 18 to 75  Previous abdominal solid organ transplant  Diagnosis of acute or chronic rejection based on clinical observations, laboratory analysis, histological evaluation.  Diagnosis of worsening allograft function based on clinical observations, laboratory analysis, histological evaluation.  Failed primary and alternate standard of care therapies  Serious or life-threatening condition or progressing to serious or life-threatening condition if not treated as evaluated by the treating physician.  In otherwise good general health as evidenced by medical history  Male or female of reproductive potential must utilize birth control method during from time of enrollment to 6 months after study completion  Exclusion Criteria:  Pregnancy or lactation  Treatment with another investigational drug or other intervention within 30 days of enrollment  Subjects with a history of laboratory evidence of hypercoagulability  Subjects with a history of deep venous thrombosis or pulmonary embolus