Inclusion Criteria:  Age: 18-80 years old, male or female; Colon cancer (ascending colon, transverse colon, descending colon, sigmoid colon) is diagnosed by histology or cytology; The clinical stage is T1-4aN0-2M0; 4 No multiple distant metastases;  5. ECOG score 0-2; 6. Heart, lung, liver, and kidney functions can tolerate surgery; 7. Patients and their families can understand and are willing to participate in this clinical study, and sign an informed consent.  Exclusion Criteria:  Past history of malignant colorectal tumors or recent diagnosis combined with other malignant tumors; Patients with intestinal obstruction, intestinal perforation, intestinal bleeding, etc. who need emergency surgery; Neighboring organs need to be combined with organ resection; New adjuvant therapy before surgery; ASA grade ≥ grade IV and/or ECOG physical status score> 2 points; Those who have severe liver and kidney function, cardiopulmonary function, blood coagulation dysfunction, or combined with serious underlying diseases that cannot tolerate surgery; Have a history of severe mental illness; Pregnant or lactating women; Patients with other clinical and laboratory conditions considered by the investigator should not participate in the trial.