Inclusion Criteria:  A COVID-19 diagnosis confirmed with a SARS-CoV-2 infection positive polymerase chain reaction (PCR) within 30 days of screening. Age 18-80 years.  Severity of disease according to the following criteria (at least one clinical parameter and one laboratory parameter are required):  a. Clinical and Imaging-based evaluation i. Respiratory rate > 23/min and < 30/min ii. SpO2 at room air ≤94% and ≥90% iii. Bilateral pulmonary infiltrates >25% within 24-48 hours or a severe deterioration compared to imaging at admission.  b. Evidence of an exacerbated inflammatory process i. LDH > 300 U/L or what is the upper limit for normal per age ii. CRP >25 mg/L iii. Ferritin >500 ng/ml iv. Lymphocytes <800 cells/mm3 v. D-dimers > 500ng/ml  Willing and able to sign an informed consent.  Exclusion Criteria:  Any concomitant illness that, based on the judgment of the Investigator might affect the interpretation or the results of the study (i.e., immunodeficiency). Mechanically-ventilated patient or patient who will probably require ICU admission or mechanical ventilation within 24 hours from enrolment, according to the Investigator's judgment. Previous complete or partial vaccination for SARS-CoV-2. Pregnancy [positive urine pregnancy test (women of childbearing potential only)] or breastfeeding. Participation in any other Interventional study in the last 30 days Active cancer.