Inclusion Criteria:  18- 70 years old Not allergic to PPF5%, NS and RL, No morphological or functional cardiac valve/s changes, cardiac ischemia, significant arrhythmias or in failure, Patients with normal liver function tests before surgery and has no chronic active liver disease, Patients with normal kidney functions.  Exclusion Criteria:  Patients with cardiac disease, Kidney disease, Liver dysfunction, Those who receive additional blood products other than PRBCs.