Inclusion Criteria:In order to be eligible to participate in this study, an individual must meet all of the following criteria:  Provision of signed and dated informed consent form Stated willingness to comply with all study procedures and availability for the duration of the study Age 18-45 years In good general health as evidenced by medical history and lean (BMI 18.5-24.9 kg/m2) or non-diabetic obese (BMI 30-50 kg/m2) with a fasting plasma glucose (FPG) <100 mg/dL and a hemoglobin A1c <5.7%.  Exclusion Criteria:  An individual who meets any of the following criteria will be excluded from participation in this study:  Hypertension Cardiac or pulmonary disease, Known history of Type 1 or Type 2 diabetes Hepatic disease, swallowing and gastrointestinal disorders Current use of anti-obesity medications, supplements and/or anti-hyperglycemic medications Neurological injury or illness, and psychiatric medications Women who are pregnant or lactating Subjects who suffer from claustrophobia Subjects who have received a diagnostic or therapeutic radiopharmaceutical within 7 days prior to participation in this study Radiation works or participation in other research studies involving ionizing radiation within one year of the PET scans that would cause the subject to exceed the yearly dose limits. Subjects with history of IV drug use which would prevent venous access for PET tracer injection Severe motor problems that prevent the subject from lying still for PET and MR imaging Subjects who complain of chronic pain Blood donation within 8 weeks of the study