Inclusion Criteria for Cancer Arm Participants:  Ability to provide a written informed consent 40-75 years old Ability to comply with study procedures Confirmed diagnosis or suspicious cases of one of the 9 types of cancers within 42 days prior to study blood draw. No prior anti-cancer therapy (local or systematic) prior to study blood draw  Exclusion Criteria for Cancer Arm Participants:  Pregnancy or lactating women Recipients of organ transplant or prior non-autologous (allogeneic) bone marrow transplant or stem cell transplant Recipients of blood transfusion within 7 days prior to study blood draw Recipients of any anti-cancer therapy within 30 days prior to study blood draw, due to diseases other than cancer Known prior diagnosis of malignancies, other current malignant diseases or multiple primary tumors No confirmed diagnosis of cancer by histopathological or radiological assessments within 42 days of study blood draw, or diagnosis of a benign disease or precancerous lesions by histopathological assessments, or inability to characterize whether the lesion is malignant or benign  Inclusion Criteria for Healthy Arm Participants:  Ability to provide a written informed consent 40-75 years old No cancer-related symptoms or discomfort within 30 days prior to study blood draw Ability to comply with study procedures No clinically significant finding by laboratory tests and radiology examinations  Exclusion Criteria for Healthy Arm Participants:  Pregnancy or lactating women Recipients of organ transplant or prior non-autologous (allogeneic) bone marrow transplant or stem cell transplant Recipients of blood transfusion within 7 days prior to study blood draw Clinically significant or uncontrolled comorbidities Prior or ongoing treatment of cancer within 3 years prior to study blood draw