Inclusion Criteria:  Age 18 to 65 years of age Weight 60 kg to 90 kg  Willing and able to  communicate in English or Spanish provide written informed consent to take part in the study be available for all visits and able and willing to comply with all study procedural requirements  In general good health in the opinion of the investigator as defined by:  The absence of clinically significant illness or surgery within 4 weeks of dosing. Participants vomiting within 24 hours before the first study drug administration will be carefully evaluated for upcoming illness/disease. Inclusion pre-dosing is at the discretion of the Investigator or designee. The absence of clinically significant neurological, endocrine, cardiovascular, respiratory, hematological, immunological, psychiatric, gastrointestinal, renal, hepatic, and metabolic disease including uncontrolled diabetes. Agree not to participate in other concurrent interventional and/or drug trials Agree not to use nicotine containing products Agree not to eat grapefruit, drink grapefruit juice or take St. John's wort for 5 days prior to study drug dosing and throughout the study.  If you or your heterosexual partner is pre-menopausal, you must agree to use an effective method of contraception and to continue use of an effective method for the duration of study participation and 2 weeks after. For this study, a clinical history of amenorrhea for ≥1 year without a separate identifiable cause and a medical history consistent with menopause meets criteria for post-menopausal. Acceptable methods are:  condom use together with an additional barrier method plus spermicide, hormonal methods, or an IUD sterilization of participant or partner heterosexual abstinence  Exclusion Criteria:  Pregnant or lactating History of hypersensitivity to the EQU-001 API History of EQU-001 API use within the previous 2 weeks History of ocular conditions that interfere with pupillometry including inability to focus on an object 3 meters in front of them, current eye disorder under the care of an ophthalmologist, or pupil not readily distinguishable from the iris History of excessive caffeine use (>8 cups of coffee or caffeine-containing energy drinks per day) History of smoking or vaping within the past 3 months History of substance abuse within 6 months (with the exception of medically indicated marijuana), including alcohol Use of concomitant prescription medications within 5 days of the study drug dose Use of an investigational drug or device or participation in an investigational study within 30 days prior to enrollment Donation of blood within the previous 4 weeks  Has any of the following laboratory abnormalities at screening or baseline:  Breathalyzer result ≥ 0.1 Positive COVID test Positive urine drug screen Positive urine cotinine screen Total bilirubin or higher ≥ 1.5 x the site laboratory ULN ALT or ALT ≥ 2 x the site laboratory ULN HbA1c ≥ 6.5% Positive hCG (female pre-menopausal participants) Received a COVID-19 vaccine within 7 days of the baseline visit Any reason which, in the opinion of the PI, would prevent the subject from participating in the study