Inclusion Criteria:  Patients with localized leiomyosarcoma (LMS) of extremity, body wall or retroperitoneum Grade 2 or 3, or high-grade LMS Tumor size >5 cm in greatest dimension Primary tumor amenable to complete resection There is no age requirement; however, high-grade LMS is exceeding rare in children Participant agrees to receive neoadjuvant doxorubicin and ifosfamide combination chemotherapy If pre-operative radiation is administered, it must be administered after chemotherapy. Post-operative radiation may be administered Archival tumor tissue (either frozen sample, tissue block containing tumor, or minimum of 4 unstained slides and 1 H&E stained slide) from diagnostic or pre-treatment biopsy available for study research