Inclusion Criteria:  Diagnosed with pSS by meeting the 2016 ACR/EULAR Classification Criteria. The patient complained of dry mouth and eyes. Positive anti-SSA/Ro-60 antibody at screening. IgG≥16 g/L. No hormone, immunosuppressant, biological agents or other treatments were received within 4 weeks before screening; Pregnancy test of is negative. Use effective contraceptives during the trial (female) Those who did not participate in any drug trial within 12 weeks before enrollment  Exclusion Criteria:  Pregnant or lactating or planning to get pregnant during the duration of the study. Complicated with other CTD Complicated with malignancy mental illness, a history of alcohol abuse, immunodeficiency, uncontrolled infections, and drug or other substance abuse serious systemic damage, glucocorticoids, other immunosuppressants and biological agents should be added to control the condition: Heart, liver (transaminase/bilirubin >1.5 times the upper normal limit), kidney (Cr≥133mmol/L), lung (FVC % < 60%), blood (white blood cell <3×109/L, HGB<80g/L, PLT<80×109/L), etc. Fundus/visual field lesions; Allergic to any component of the study drug (IGU and/or HCQ); the investigator considers the patient to be unsuitable for entry into the study