Inclusion Criteria:  Over 18 years Both genders Diagnosis of COVID-19 (SARS-COV2) with moderate to severe ARDS from the Berlin classification (PaO2 / FiO2: < 200).  Exclusion Criteria:  Acute kidney failure. Severe liver failure Suspected or documented intracranial hypertension. Family history of malignant hyperthermia. History of malignant hyperthermia. Documented chronic lung disease. Documented chronic pulmonary hypertension Patients who do not sign informed consent.