Inclusion Criteria:  Male/female aged 18-80 years; Having complex coronary artery disease (SYNTAX score > 22 points) undergoing myocardial revascularization  Exclusion Criteria:  Cardiogenic shock or hemodynamic instability; Undergoing other heart surgery at the same time; Previous coronary artery bypass surgery; History of cerebral hemorrhage; Ischemic stroke in the past six months; History of cancer; Life expectancy no more than 12 months