Inclusion Criteria  Adult participants are eligible to be included in the study only if all of the following criteria apply:  Type of Participant and Disease Characteristics  Participants with documented spontaneous intraparenchymal hemorrhage within 48 hours of symptom onset (or last seen normal) and  Qualifying for at least one of the following categories:  i. history of symptomatic coronary, peripheral and/or carotid artery disease (severe atherosclerotic vascular disease), or ii. visualized extracranial cervical/intracranial atherosclerotic disease causing any degree of stenosis/occlusion or presence of aortic arch plaque with maximum thickness ≥1 mm (moderate atherosclerotic vascular disease), or iii. two or more risk factors including: age 60 years or older, hypertension, dyslipidemia, diabetes mellitus, chronic kidney disease (eGFR: 15-50mL/min), history of ischemic stroke or current smoking (mild atherosclerotic vascular disease)  Informed Consent  Capable of giving signed informed consent either independently, or by a legally authorized representative (LAR), which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol.  Exclusion Criteria  Participants are excluded from the study if any of the following criteria apply:  Medical Conditions  Secondary causes of ICH (relating to trauma, macrovascular anomalies, neoplasms or bleeding diathesis) Inflammatory bowel disease or chronic diarrhea Cirrhosis or severe hepatic dysfunction  Renal insufficiency (eGFR <15mL/min)  Prior/Concomitant Therapy  Concurrent treatment with strong CYP3A4 inhibitors (atazanavir, clarithromycin, darunavir/ritonavir, indinavir, itraconazole, ketoconazole, lopinavir/ritonavir, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, tipranavir/ritonavir) or P-gp inhibitors (cyclosporine, ranolazine) Known allergy or sensitivity to colchicine  Strong indication for colchicine where assignment to placebo is deemed unacceptable  Other Exclusions  Pregnant or breast-feeding Inability to adhere to study procedures Estimated life expectancy less than 6 months at the time of enrollment Close affiliation with the investigational site; e.g. a close relative of the investigator, dependent person (e.g., employee or student of the investigational site)