Inclusion Criteria:  18~75 years old, male or female associated past medical history, including asthma, bronchiectasis, COPD ect. elevated serum total IgE (>100IU/mL) elevated aspergillus specific IgE  Exclusion Criteria:  According to the investigator, the patient has other factors that may affect the results of the study or lead to the termination of the study, such as alcohol abuse, drug abuse, other serious diseases (including mental illness). Pregnancy or breastfeeding Abnormality of liver or kidney function