Inclusion Criteria:  Willing and able to provide signed and dated informed consent prior to any study-related procedures and willing and able to comply with all study procedures. Healthy male and female subjects, 18-65 years of age (inclusive). Body Mass Index (BMI) between 18 and 32.0 kg/m2. Generally, in good health, with no history of chronic or serious cardiovascular, hepatic, renal, respiratory, blood and lymphatic system, endocrine, immune, mental, neurological, psychiatric, gastrointestinal and allergic diseases. Vital signs, physical examination, clinical laboratory tests (CBC with differential, urinalysis, blood biochemistry, coagulation, pregnancy test (females), urine drug test and lipid panel , etc.), and 12-lead ECG should be within normal reference range or abnormal not clinically significant at screening and Admission (Day -1). For eligibility purposes, abnormal laboratory or vital signs results may be repeated once if abnormal result is observed at the initial reading. Moreover, Blood pressure must be within 90/50-140/90 mm/Hg. Respiratory rate must be within 12-18/minutes. Pulse must be within 60- 100/minute and the oral temperature must be < 99.0 oF. No prescription or non-prescription drug within 14 days prior to the study drug administration and throughout the study. Women of non-childbearing potential defined as being surgically sterile (bilateral oophorectomy and hysterectomy) or menopause confirmed by FSH and Estradiol levels in accordance with local laboratory reference ranges. Women of childbearing potential who are not pregnant or breast-feeding must consent to use acceptable contraception (Section 5.3) during the study and for an additional 30 days after the administration of study drug. Men with a partner of childbearing potential must consent to use acceptable contraception (Section 5.3) during the study and for an additional 90 days after the administration of study drug.  Exclusion Criteria:  Pregnant or breastfeeding woman. Within 5 years prior to the study, subjects with history of cardiovascular,respiratory, kidney, liver, metabolism, endocrine, gastrointestinal, blood, nerve, skin and mental illness, cancer or other major disease that in the judgement of the Investigator might put the subject at risk on this study. History of autoimmune disease. Known history or family history of hereditary immunodeficiency; History of recurrent infection suggestive of immune deficiency. Positive test at screening for human immunodeficiency virus antibody (HIV1/HIV2), hepatitis C antibody or hepatitis B virus surface antigen (HBsAg) or hepatitis B core antibody (HBcAb), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing. Significant infections requiring hospitalization or intravenous antibiotics or as judged by the investigator within 3 months prior to dosing. Symptomatic viral, bacterial (including upper respiratory infection), or fungal (including cutaneous) infection within 1 week prior to dosing. Received live or attenuated vaccines within 6 weeks prior to dosing, or plan to be vaccinated with live or attenuated vaccines during the study or within 6 weeks after dosing. Received any experimental drugs or devices or have participated in a clinical study within 60 days prior to admission. Allergy to study drug or components of its formulation or history of a Grade 3-4 allergic reaction to treatment with another protein product. Abuse on alcohol, cannabis- derived products or other drugs. Positive urine drug test (amphetamines, barbiturates, benzodiazepines, cannabinoids, cocaine, cotinine and opiates) at screening and admission. Smoking or use of other nicotine-containing products (snuff, chewing tobacco, cigars, pipes or nicotinereplacement products such as nicotine chewing gum and nicotine plasters) within 3 months prior to admission, or negative cotinine test at screening period and Day -1,or during the trial. Donated or lost ≥ 450 mL of blood or received blood transfusion or blood products within 8 weeks prior to admission or donated ≥200 mL of blood (blood components) or had blood loss (≥300 mL) within 1 month prior to admission. Poor venous access or inability to tolerate venipuncture. Any condition that the investigator or primary physician believes may not be appropriate for participating the study.