Inclusion Criteria:  Major Depressive Disorder; Patients older than 60 years Hamilton equal or higher than 17  Exclusion Criteria:  Other mental disorders (alcohol or drug addiction, psychotic disorders, dementia, bipolar disorder); Presence of serious neurological or clinical diseases; Resence of severe suicidal ideation and CIRS (Cumulative Illness Rating Scale) score> 7, characterizing a set of clinical morbidities that could impair adherence to the research protocol, bipolar disorder and/or presence of manic symptoms (hypo) demonstrated with more than 8 points in the Young Mania Rating Scale. Metal implants; Epilepsy or electronics in the cephalic segment;