Inclusion Criteria:  Age≥18 Signed Informed Consent Form (ICF) Total bilirubin ≥ 8 mg/dL  Acute Alcoholic Hepatitis diagnosed by EtOH consumption within 6 weeks of onset of symptoms, exclusion of other causes for jaundice and liver biopsy or at least 2 out of the following symptoms:  Hepatomegaly AST > ALT Elevated WBC Ascites Maddrey DF > 32  Systemic inflammation as defined by 2 fulfilled criteria out of:  leucocytosis body temperature > 38°C tachycardia > 90 bpm tachypnoeia > 20 breaths/min ACLF grade ≥2 Creatinine >2 mg/dl and increase >1.5 mg/dl despite standard of care  Exclusion Criteria:  Platelets < 40,000/mm3 INR > 3.5 MELD Score > 35 AST > 500 IU/l Bilirubin reduction > 20% in prior 72 hours (early responders to conventional Standard of Care (SOC)) Uncontrolled infection, bleeding or hemodynamic instability Small liver size (diagnosed by imaging, ultrasound/CT) Chronic dialysis Contraindications for CytoSorb® according to Instructions for Use ACLF grade <2