Inclusion Criteria:  received three doses of the quadrivalent HPV vaccine and enrolled in the quadrivalent HPV vaccine safety and immunogenicity study (MISP 38406) participant consent or parental/guardian consent and participant assent for participants still <18 years of age participants and guardians who consented to be contacted for further evaluation and participation in research and are willing to continue longer-term follow up.  Exclusion Criteria:  Did not participate in the quadrivalent HPV vaccine safety and immunogenicity study (MISP 38406) Not willing or able to provide written informed consent/assent to participate in the study