Inclusion Criteria:  Individuals of either gender between the ages of 3months (but weight ≥5 kg) and 12 years who present with symptoms compatible with acute uncomplicated malaria Minimum asexual parasite density of 1000/µl. This will be done at enrolment for all study participants. Fever with an axillary temperature≥ 37.5°C or history of fever within 24hours of presentation Residence within 15 kilometres to the study site. Ability to take drugs orally. Absence of history of ACT intake in the two weeks prior to enrolment A signed informed consent from parents or guardians of the prospective enrollee to participate in the study  Exclusion Criteria:  History of allergy to study drugs i.e. artemisinins, lumefantrine and pyronaridine Any concurrent illness that could hamper evaluation of response e.g. bacterial infections, viral infections, severe gastrointestinal disease, malnutrition (weight for height <70%). Presence of clinical evidence of severe malaria such as prostration, inability to drink or breastfeed, persistent vomiting, convulsion, severe anaemia haemoglobin <5 g/dl), unarousable coma Patients with known chronic diseases like chronic kidney disease, chronic liver disease, malnutrition, cardiac failure, Sickle Cell haemoglobin (HbSS) etc. Mixed or mono-infection with another Plasmodium species detected by microscopy; presence of severe malnutrition defined as a child aged between 6-60 months whose weight-for-high is below -3 z-score, or has symmetrical oedema involving at least the feet or has a mid-upper arm circumference < 115 mm). Parent or guardian who in the judgment of the investigator will not comply with protocol in the opinion of the investigator