Inclusion Criteria:  Age 18-80 years; Acute ischemic stroke caused by middle cerebral artery M1 segment occlusion; Successful recanalization (mTICI 2b/3) after endovascular thrombectomy that confirmed by digital subtraction angiography; Written informed consent provided by the patients or their legal relatives.  Exclusion Criteria:  Known diagnosis or clinical suspicion of cerebral vasculitis or fibromuscular dysplasia; Difficulty in reaching the designated position of the balloon used for ischemic post-conditioning; Stenting in the middle cerebral artery as rescue therapy during the thrombectomy procedures; > 2 times of balloon dilations as rescue therapy due to angioplasty during the thrombectomy procedures; Moderate or severe residual stenosis (≥ 50%) of the culprit artery after recanalization; Difficulty in complying with ischemic post-conditioning or other conditions that the investigator considered inappropriate for inclusion.