Inclusion Criteria:  Patients aged 7 to 17 who have irritability symptoms will be recruited. They will be screened for the irritability symptoms with ARI scale.  Exclusion Criteria:  Patients who are not willing to participate in the study after detailed explanation. Patients who could not follow the investigator's instructions. Patients who have problems to express questions or emotional problems exactly. Patients who have severe neurological or mental illness like epileptic disorder, history of stroke, schizophrenia, bipolar disorder, mental retardation or uncontrolled suicide risk. Patients who have severe medical illness or surgical conditions like uncontrolled abnormal thyroid function, history of heart attack, uncontrolled hypertension. Patients who are allergic to methylphenidate or dextromethorphan. Patients with autoimmune disorders Patients with asthma or severe infection disorder currently or in the previous two months to avoid the influence of the level of cytokines.