Inclusion Criteria:  Age≥55 and ≤85. The diagnosis of probable CAA and probable CAA with supporting pathology by the Boston criteria. Signed and dated informed consented is obtained.  Exclusion Criteria:  Familial hereditary CAA or other hereditary small-vessel disorders. Previous intracranial hemorrhage caused by other reasons, such as tumor, cerebral cavernous angioma, ruptured aneurysm, arteriovenous malformation, venous sinus thrombosis and so on. A history of stroke within 3 months. The degree of intracranial or extracranial large artery stenosis >50%. Clinical diagnosis of probable AD by National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) criteria. Significant cognitive impairment (defined as Mini-mental State Examination (MMSE) score of ≥20 (primary school) or ≥24 (junior school or above) or other diseases resulting from severe cognitive impairment. Inability to walk 6m unaided or other conditions that affected gait performance, such as Parkinson. Illiteracy and patients with severe visual or hearing impairment. Contraindication to MRI scan, such as intracranial metal implants, cardiac pacemaker, severe claustrophobia, history of seizures and so on. Patients with missing or poor-quality MRI sequences at baseline and follow-up. Patients with a pre-existing neurological deficits (modified Ranks scale score >2) or psychiatric disease that would confound the neurological or functional evaluations. Alcohol dependence and other psychoactive substance abuse Contraindication for remote ischemic conditioning: severe soft tissue injury, limb deformities, fracture, atrial fibrillation or peripheral vascular disease in the upper limbs. Life expectancy of less than 1 year due to co-morbid conditions. Severe, sustained hypertension (SBP > 180 mmHg or DBP > 110 mmHg). Severe renal or hepatic disease. Known pregnancy (or positive pregnancy test), or breast-feeding. Concurrent participation in another research protocol for investigation of another experimental therapy. Any condition which, in the judgment of the investigator, might increase the risk to the patient.