Inclusion Criteria for Index Subjects:  Males or females between the ages of 21-35 years-old Diagnosis of MSUD Ability to communicate verbally or using augmentative communication effectively to participate in appropriate neurocognitive testing  Inclusion Criteria for Comparison Subjects:  Males or females between the ages of 21-35 year-old Sibling or acquaintance of index subject Ability to communicate verbally or using augmentative communication effectively to participate in appropriate neurocognitive testing  Exclusion Criteria for all subjects:  Inability to communicate verbally or using augmentative communication effectively to participate in appropriate neurocognitive testing Subjects or guardians or who, in the opinion of the Investigator, may be non-compliant with study schedules or procedures. Subjects or guardians who do not have internet access Subjects who do not speak English as a primary language