Inclusion Criteria:  Males and females aged ≥18 years old Able and willing to give informed consent and attend study visits Controlled intraocular pressure (IOP) (≤21 mmHg) in both eyes Prior to screening, 3 or more Humphrey Visual Field (HVF) tests (with acceptable reliability standards) or 3 or more Optical Coherence Tomography (OCT) studies of the study eye on record Open angle glaucoma that is progressing in the study eye  Exclusion Criteria:  Considerations for either eye  Best Corrected Visual Acuity (BCVA) at Baseline of ≤64 letters (Snellen equivalent of worse than 20/50) Severe open angle glaucoma Glaucoma due to non-open angle causes  Worse than mild non-proliferative diabetic retinopathy  Considerations for study eye:  Visual field results suggestive of another disease (eg, altitudinal field defect) Evidence of macular edema based on OCT imaging and Investigator's judgement Previous intravitreal (IVT) injections, history of retinal surgery, history of retinal laser Cataract surgery within 3 months of Screening or yttrium-aluminum-garnet capsulotomy (YAG) within 4 weeks of Screening  Anticipated need for surgical or procedural intervention for glaucoma, cataract, posterior capsular opacity, refractive error, or retinal conditions during the study  Other general exclusion criteria:  The requirement for oral carbonic anhydrase inhibitors to control intraocular pressure Severe, unstable, or uncontrolled cardiovascular, diabetic, renal, or pulmonary disease, based on Investigator's judgement Systolic blood pressure >180 mmHg or diastolic blood pressure >110 mmHg Women who are pregnant, breastfeeding, or contemplating pregnancy during the study period and men who are contemplating contributing sperm for a biologic child during the study period