Inclusion Criteria:  Each patient should have at least four teeth with a probing depth ≥of 5mm. Patients with good domestic oral hygiene will be include (documented with a full mouth plaque index of ≤ 30% before starting the clinical trial)  Exclusion criteria:  Patients receiving periodontal therapy and/or antibiotics within the previous six months Patients with diseases or medication with an inhibitory or promoting effect on periodontal healing, including anticoagulants, anti-inflammatories. Pregnant or nursing women Patients allergic to the test product will be excluded.