Inclusion Criteria:  Diagnosed as acute fat-soluble drug and organophosphorus (fat-soluble) pesticide poisoning; Conventional treatment is ineffective, especially for patients with circulatory failure, such as ventricular arrhythmia, shock, cardiac arrest, etc., who need intravenous fat emulsion treatment; Those who are not allergic to fat milk; Sign informed consent.  Exclusion Criteria:  Mergers with insufficiency of important organs; Patients with malignant tumors; Severe mental disorder affects the treatment; Those with incomplete clinical data.