Inclusion Criteria:  Male and female subjects with age ≥ 21 years old and < 70 years old. BMI ≥ 30 kg/m2 and ≤ 50 kg/m2 Abnormal sex-specific ALT (female ≥ 32 U/L; male ≥ 41 U/L), but less than 100 U/L within the last 3 months Negative tests for viral hepatitis C (hepatitis C antibody) and autoimmune hepatitis (anti-smooth muscle antibody) Elastography result positive for fibrosis grade F2 through F4 (that is, LSM between 8 and 124 kPa) and/or steatosis grade S1 through S3 (that is, CAP ≥ 248 dB/m) within the last 3 months  Exclusion Criteria:  Type 1 diabetes mellitus Subjects with type 2 diabetes mellitus who use insulin Heart failure New York Hear Association (NYHA) stage 3 or 4 Myocardial infarction within last 6 months Unstable angina Chronic kidney disease with estimated glomerular filtration rate (eGFR) ≤ 30 mL/min/1.73 m² Chronic obstructive pulmonary disease requiring oxygen supplementation Coexisting liver disease or end-stage liver disease Severe or uncontrolled mental health disease Gout History of uric acid nephrolithiasis Porphyria Conception attempts, confirmed pregnancy or breast feeding Past or active cholecystitis without cholecystectomy Uncontrolled hyperthyroidism Uncontrolled hypothyroidism with TSH ≥ 10 micro international units/mL Excessive alcohol consumption (that is, an AUDIT-C score ≥ 4 for men and ≥ 3 for women) Use of medicines for weight loss within last 3 months Use of warfarin, lithium, chronic use of prednisone (20 mg or more daily)