Inclusion Criteria:  Patients 18 years of age or older. History of an extremity fracture. Prior definitive fracture management with external fixation, internal fixation, or joint fusion. Superficial, deep, or organ space surgical site infection (SSI) (as per Center for Disease Control criteria) at the fracture site that requires operative management. Will have all planned SSI care surgeries performed by a participating surgeon or delegate. Provision of informed consent.  Exclusion Criteria:  Fractures of the hand cannot be imaged. Iodine allergy. Burns at the SSI site. Incarceration. Expected survival of less than 90 days. Problems, in the judgment of study personnel, with maintaining follow-up with the patient. Adults unable to consent or whom do not have a legal authorized representative Individuals who are not yet adults (infants, children, teenagers) Pregnant or breastfeeding women History of cutaneous photosensitivity, porphyria, hypersensitivity to porphyrins, photodermatosis, exfoliative dermatitis. History of liver disease within the last 12 months. Elevated liver function tests (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase or bilirubin levels greater than 2.5 times the normal limit) from laboratory tests conducted within 30 days prior to surgery. Serum creatinine in excess of 180 µmol/L within 30 days prior to surgery. Inability to comply with the photosensitivity precautions associated with the study