Inclusion Criteria:  Histopathologically confirmed diagnosis of an advanced, unresectable, or metastatic solid malignant tumor (including lymphoma; dose-escalation phase only) that has failed to respond to standard therapies; Male or female patients age 18 or older; Measurable or evaluable disease by RECIST v 1.1, or PCWG3 for prostate cancer; Capable of understanding and complying with protocol requirements; A life expectancy of greater than 8 weeks at Screening; An ECOG PS of 0 to 2; Written informed consent from the patient or the patient's legally acceptable representative prior to the initiation of any study procedures;  Adequate bone marrow, liver, and renal function as defined below:  Hemoglobin ≥ 8.0 g/dL (transfusions and/or erythropoietic stimulating growth factors allowed); Absolute neutrophil count ≥ 1500/μL; Platelet count ≥ 75,000/ μL;; Alanine aminotransferase and aspartate aminotransferase ≤ 2.5 × the upper limit of normal (ULN) or ≤ 5 × ULN for patients with known hepatic metastases; Total serum bilirubin ≤ 1.5× ULN or ≤ 2 .0 × ULN if liver metastases are present. Patients with a known history of Gilbert's syndrome (≤ 3.0 × ULN) and/or isolated elevations of indirect bilirubin are eligible for study participation; Estimated creatinine clearance ≥ 40 mL/min(using the Cockcroft Gault formula); Adequate cardiac function as estimated by left ventricular ejection fraction (LVEF) > 50% by multiple-gated acquisition (MUGA) or echocardiogram (ECHO); Negative pregnancy test for women of childbearing potential (women of childbearing potential and men must agree to use adequate contraception [hormonal or barrier method of birth control] prior to study entry and for the duration of study participation.  [NOTE: Sexual abstinence is considered a highly effective method only if defined as refraining from heterosexual intercourse during the entire period of risk associated with the study intervention. The reliability of sexual abstinence needs to be evaluated in relation to the duration of the study and the preferred and usual lifestyle of the patient]. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately).  Exclusion Criteria:  New York Heart Association (see Appendix 5) Class III or IV cardiac disease, myocardial infarction within the past 6 months, unstable arrhythmia, a history of risk factors for Torsades de Pointes, including heart failure, hypokalemia, and family history of long QTc syndrome, or evidence of ischemia on ECG; Baseline QTc exceeding 470 msec (using the Fridericia's formula) and/or patients receiving Class 1A or Class III antiarrhythmic agents or concomitant medications that prolong the QT/QTc interval; Active, uncontrolled bacterial, viral, or fungal infections requiring systemic therapy; Treatment with simvastatin unless it can be stopped prior to and during the study. Treatment with strong inhibitors and inducers of CYP3A4 or narrow therapeutic index substrates of CY3A4, CYP2B6, CYP1A2, CYP2C9 and CYP2C8, unless these can be stopped prior to and during the study Known sensitivity to DZ-002 or drug excipients Pregnant (confirmed by serum or urine pregnancy test) or is breast feeding; Treatment with radiation therapy, surgery, chemotherapy, or investigational therapy within 30 days prior to study entry (6 weeks for nitrosoureas or Mitomycin C); Unwillingness or inability to comply with procedures required in this protocol; Known infection with human immunodeficiency virus and CD4 lymphocyte count < 200 cells/mm3 , or active hepatitis B virus, or hepatitis C virus infections; Serious nonmalignant disease (e.g., hydronephrosis, liver failure, or other conditions) that could compromise protocol objectives in the opinion of the investigator and/or the Sponsor; Patients who are currently receiving any other investigational agent.