Inclusion Criteria:  Patients must meet all the following criteria for study entry:  Males aged ≥ 18 years at the time of consent No previously diagnosed prostate cancer No previous prostate biopsy  Having undergone MRI within 6 months prior to randomisation and meet one of the following criteria:  PI-RADS 2 AND ≥1 red flag defined as:  PSA density >0.1 Abnormal DRE Strong family history (1 first degree relative or ≥2 second degree) BRCA mutation PSA >10 PSA doubling time <36 months PSA velocity >0.75/year PI-RADS 3 Scheduled for prostate biopsy Willing and able to comply with all study requirements  Exclusion Criteria:  Patients who meet any of the following criteria will be excluded from study entry:  Having a PSA >20ng/ml Having ≥ cT3 on DRE Significant morbidity that, in the judgment of the investigator, would limit compliance with study protocol