Inclusion Criteria:  Patients with a confirmed diagnosis of Cystic Fibrosis regardless of CFTR genotype Persons affiliated to the social security system Minor or major patients able to expectorate spontaneously or after induction Consent signed by the patient or the holder of parental authority for the children  Exclusion Criteria:  Persons deprived of liberty, persons under guardianship or curatorship, persons in emergency situations Persons non affiliated to a social security system or not entitled Pulmonary transplant patients Refusal to participate to the study