Inclusion Criteria:  Participant is willing and able to give and sign a written informed consent for participation in the study Male, aged 18 years or above Diagnosed with prostate cancer at low or high risk Candidate to active surveillance (in case of low-risk disease) or treatment with curative intent such as radical prostatectomy or radiation therapy (in case of low risk patients not willing to undergo active surveillance or patients with high risk disease) Healthy participants undergoing a visit at the site for reason other than cancer diagnosis (including prostate cancer)  Exclusion Criteria:  History of other malignancies other than prostate cancer (for healthy participants includes also prostate cancer) Undergone surgery or treatment for prostate cancer before enrolment Presence of known severe coagulation or haematological disorder Absence of written signed informed consent for participation in the study