Inclusion Criteria:  Those who have been diagnosed with disease to be studied and do not respond to exist treatments  Ulcerative colitis, Crohn disease : Patient who does not responding to anti- TNF treatment for more than 3 month. Irritable bowel syndrome, Functional dyspepsia : Patient who does not responding to pharmacological therapies and serotonin uptake inhibitor for more than 6 month. Recurrent of Refractory CDI, NASH, Obesity : Patient who does not responding to treatment for more than 6 month.  Exclusion Criteria:  Neutrophil (<0.5 x 10*9/L) Leukocytosis (> 30.0 x 10*9/L) Toxic megacolon confirmed in abdomen Xray Pregnant or lactating women