Inclusion Criteria:  1. Healthy male and female participants 2 aged 18-65 years 3 BMI 18.0-35.0 kg/m2, maximum weight 100 kg 4 in good health, as determined by: 4a medical history, 4b physical examination, 4c vital signs assessment, 4d 12-lead ECG 4e clinical laboratory evaluations 5 provision of informed consent and abide by study restrictions  Exclusion Criteria:  not willing to abide by contraception restrictions donated blood in previous 3 months, plasma previous 7 days, platelets previous 6 weeks consumption >14 units of alcohol/week tobacco smoking concomitant medication, apart from treatments for mild asthma, eczema, contraception, paracetamol herbal remedies history of anaphylaxis, drug allergy, clinically significant atopic condition as determined by Investigator clinically significant medical history, as determined by the Investigator positive hepatitis, HIV serology live vaccine in previous 3 months, Covid-19 vaccine prior 14 days Participants who, in the opinion of the Investigator, should not participate in this study.