Inclusion Criteria:  The inclusion criteria for participants including;  • Patients who met the histological criteria for presence of parasite Age of older than 4 years and both gender. Lesions are less than 5 in number in each patient Size of lesion is less than 5cm2 Participants who had stopped therapy greater than 4 weeks earlier and the lesions were not improving. Duration of disease for patients under trial was six months (acute) and more than one year (chronic).  Exclusion Criteria:  The following patients were excluded:  Whose clinical data were incomplete Participants who had received any anti anti-leishmanial or immunosuppressive drugs in the last 15 days Patients with co-morbid conditions, immunocompromised patients, Lactating mothers and pregnant women.