Inclusion Criteria:  Immunocompetent individuals, 12 years of age or older with an uncomplicated abscess  Uncomplicated abscess is defined as ≤8 cm of induration (defined as firmness to touch) at the greatest diameter. ≤4 cm of surrounding erythema (surrounding redness). Defined area of central fluctuance may or may not be present. Patient must be able to answer questions. Patient must be medically stable as defined by the emergency department physician. Patient must participate voluntarily in the study.  Exclusion Criteria:  Currently receiving antibiotics or received antibiotics within the last 72 hours. Evidence of systemic infection (fever, aches, chills, nausea). Requires admission to the hospital for infection or for any other reason(s). Abscess caused by a human or animal bite. Prior history of hypersensitivity or allergy to Chlorhexidine Gluconate (CHG). Immunodeficiency (examples: HIV positive, Crohn's disease, systemic lupus erythematosus, Addison's disease, psoriasis, splenectomy, leukemia, cancer (on chemotherapy)). Currently on any immune-modifying medication (examples - prednisone, antivirals). History of chronic skin infection (3 or more in the past year). Chronic medical problem (for example, end-stage heart, liver, kidney or lung disease, diabetes mellitus, peripheral vascular disease, history of organ transplant). Mental illness, including but not limited to, substance abuse, dementia, schizophrenia or mentally handicapped or challenged. Incarcerated. Patient is pregnant or thinks she may be pregnant.