Inclusion Criteria:  Hospitalised children (aged <18 years old) SARS-CoV-2 infection associated disease (clinically suspected or laboratory confirmed) with evidence of single or multi-organ dysfunction (called Pediatric Multisystem Inflammatory Syndrome temporally associated with COVID-19 [PIMS-TS]). No medical history that might, in the opinion of the attending clinician, put the patient at significant risk if he/she were to participate in the trial  Exclusion Criteria:  Neonates/infants with a corrected gestational age of <= 44 weeks If the attending clinician believes that there is a specific contra-indication to one of the active drug treatment arms or that the patient should definitely be receiving one of the active drug treatment arms, then that arm will not be available for randomisation for that patient.