Inclusion Criteria:  Age ≥ 18 years or older A diagnosis of cancer with no restrictions placed on type of cancer or stage. Eligibility criteria will not be restricted to MSK confirmed biopsy/diagnosis. Participating institution's testing is sufficient for other study sites Completed active treatment (surgery, chemotherapy, and/or radiotherapy) at least one month prior to study initiation (patients on continued hormone treatment or maintenance targeted therapies will not be excluded). Patients currently have no evidence of disease Ambulatory (Karnofsky functional score of ≥ 60) Having a focused location of regional musculoskeletal pain (e.g. joints, extremities, back, neck) that can be covered by one patch of PRP Worst pain score (numeric pain rating scale) 5 or above in the preceding week Pain for at least 3 months and at least 15 days with pain in the preceding 30 days; and willingness to adhere to and understanding of all study-related procedures, including randomization to one of the two possible choices Able to understand informed consent and provide signed informed consent form  Exclusion Criteria:  Patients with non-musculoskeletal pain syndromes (headache, facial pain, chest pain, visceral abdominal pain) will be excluded if these are the sole source of pain but can be present as co-morbid conditions as long as a patient has a primary musculoskeletal pain condition defined as above. Patients have generalized musculoskeletal pain such as fibromyalgia Use of corticosteroid drugs by any route of administration within 30 days Patients with significant self-reported skin disorders Patients with open wounds, infections, skin trauma at skin overlying area of pain Patients with documented history of skin sensitivity to adhesive or allergic reaction to other patches or topical analgesics Patients with documented skin allergic reaction to plants or herbs Patients who are in active treatment (chemotherapy, surgery, radiotherapy) Plan to change or initiate other pain medications or interventions (e.g. physical therapy, acupuncture, injection). Patients may remain on their current pain regimen.