Inclusion Criteria:  The patient's parent or legal representative has provided informed consent Must be receiving medical care in an intensive care unit Age less than 18 years. Body weight between ≥10 and ≤ 20 kilograms Intent to receive full supportive care through aggressive management Clinical diagnosis of AKI requiring CRRT At least one non-renal organ failure OR presence of proven/suspected sepsis  Exclusion Criteria:  Threshold blood pressure of 80/40 mmHg Patients with a solid organ transplant or those with a bone marrow or stem cell transplant in the previous 100 days or who have not engrafted Acute or chronic use of circulatory support device, other than extracorporeal membrane oxygenation (ECMO) Presence of preexisting advanced chronic renal failure on chronic renal replacement therapy or with an estimated glomerular filtration rate less than 30 mL/min/1.73m2 AKI occurring in the setting of burns, obstructive uropathy, scleroderma renal crisis, atheroembolism, functional or surgical nephrectomy, cyclosporine or tacrolimus nephrotoxicity Metastatic malignancy which is actively being treated or may be treated by chemotherapy or radiation during the subsequent three month period after study therapy Chronic immunosuppression with the exception of corticosteroids up to a dose of 10 mg of prednisone per day Known positive HIV or AIDS or COVID-19 Current Do not Attempt Resuscitation (DNAR), Allow Natural Death (AND), or withdrawal of care status, or anticipated change in status within the next 7 days Patient not expected to survive 28 days because of an irreversible medical condition Any medical condition that the Investigator thinks may interfere with the study objectives Treating clinician does not feel it is in the best interest of the patient Platelet count <15,000/mm3 Concurrent enrollment in another interventional clinical trial Use of any other investigational drug or device within the previous 30 days Use of AN-69 hemofilter membrane for CRRT