Inclusion Criteria:  - all patients with PAD candidates for revascularization procedures  Exclusion Criteria:  planned long-term dual antiplatelet therapy (>6 months), clinical requirement for therapeutic anticoagulation, recent acute limb ischemia or acute coronary syndrome, medical condition that could increase the risk of major bleeding, significantly impaired renal function at baseline (estimated glomerular filtration rate <15 mL•min-1•1.73 m-2), any documented history of intracranial hemorrhage, stroke, or transient ischemic attack