Inclusion Criteria:  The course of the disease is more than 6 months, and it is clearly diagnosed as ulcerative colitis with depression.【Diagnostic criteria: (2020) "JSGE Evidence-based Clinical Practice Guidelines: Inflammatory Bowel Disease" and "Chinese Mental Disorders Classification and Diagnostic Standards" (CCMD) -3) The relevant standards in the above, and also meet the improved Mayo score ≤ 10 points, PHQ9 score ≥ 5 points】; There is no restriction on men and women, aged between 18-65 years old; BMI is between 18-30kg/m2; Have basic reading comprehension skills; No other serious diseases such as heart, brain, lung, liver, and kidney are complicated; Have not traveled abroad in the past month, and have no history of alcoholism, drug abuse, or smelting; No antibiotics and probiotic preparations have been used within one month; Agree to participate in this study and sign an informed consent form.  Exclusion Criteria:  Age <18 years old or >65 years old; Patients with unspecified ulcerative colitis; Authors with bipolar disorder, persistent mood disorder, and mania; Malignant tumors such as gastrointestinal infection, irritable bowel syndrome, bowel cancer and other gastrointestinal diseases; A history of gastrointestinal surgery; Patients during pregnancy and lactation; Complicated with obesity, hypertension, diabetes, heart disease, stroke and other serious chronic diseases (hereditary, metabolic, endocrine diseases); Infectious diseases: hepatitis B or C, HIV, syphilis (rapid recovery of positive plasma), Epstein-Barr virus and cytomegalovirus infection (IgM positive); Abnormal liver function: AST or ALT higher than 2 times the upper limit of normal; renal insufficiency: serum Cr higher than 1.5 times the upper limit of normal or eGFR<60ml/min; dyslipidemia (TC> 4.0 mmol/L, TG >2.0 mmol/L, LDL-c>2.5 mmol/L, HDL-c<1.0 mmol/L), CRP>8mg/L; Anticoagulation therapy; Patients who were participating in other clinical trials at the time of enrollment; Those who do not agree to join the group or have various factors affecting compliance and other people who are not suitable for participating in clinical trials.