Inclusion Criteria:  - Patients scheduled for mitral valve surgery via port access, aortic valve replacement via right anterior thoracotomy and minimal invase direct coronary artery bypass  Exclusion Criteria:  Patients who are pregnant or breastfeeding BMI >35 Opioid abuse Patients known with chronic pain Patients known with allergy to local anaesthetics (in this case levobupivacaine) Patients known with hypersensitivity to piritramide Patients who receive medication that could possibly interact with levobupivacaine (sa. mexilatine, ketoconazol, theophylline) Patients who simultaneously participate in another interventional clinical trial, unless the Principal Investigators of the clinical trials give consent by mutual agreement that the patient can participate in another interventional clinical trial Soft tissue infection in the area of the procedure