Inclusion Criteria:  Pseudomyxoma peritonei diagnosis through imaging tests and/or histological studies Pseudomyxoma peritonei relapse in abdominal area in patients who comply inoperability criteria, which are:  At least two HIPEC operations or major abdominal surgery (PSS > 3). Patients with acute morbidities (ASA score IV)  ECOG 0-2 Age ≥ 18 Signs informed consent  Exclusion Criteria:  Candidates to other potentially healing treatments Allergy to bromelains (pineapple), N-Acetylcysteine or possible cross-reactive allergy (eggs, sulphate. latex, carrots, celery, wheat...) Non-manageable coagulation alterations No possibility of intraabdominal drainage catheter Acute respiratory pathology (asthma, COPD), acute hepatic, cardiopathic or kidney pathology Allergy to any substance that might cause crossed reactivity to bromelain Unwillingness to participate in this clinical trial