Inclusion Criteria:  a diagnosis of Parkinson's Disease; a disease duration between 2 and 5 years at baseline  Exclusion Criteria:  past or concomitant autoimmune disease previous or ongoing immune-modulating or immunosuppressive therapy inflammatory bowel diseases, colorectal diseases or past major abdominal or pelvic surgery antibiotics therapy up to three months before enrolment usage of tube feeding known or suspected allergy to any component of the treatment or placebo mixtures known and established cognitive decline or any comorbidity preventing reliable completion of trial assessments motor fluctuations