Inclusion Criteria:  adults and pediatric patients with positive results of direct SARS-CoV-2 viral testing 12 years of age and older weighing at least 40 kg are at ":high risk" for progressing to severe COVID-19 and/or hospitalization  High risk is defined as patients who meet at least one of the following criteria:  Have a body mass index (BMI) >35 Have chronic kidney disease Have diabetes Have immunosuppressive disease Are currently receiving immunosuppressive treatment Are over 65 years of age Are over 55 years of age AND have: cardiovascular disease, OR hypertension, OR chronic obstructive pulmonary disease/other chronic respiratory disease Are 12 - 17 years of age AND have BMI >85th percentile for their age and gender based on CDC o growth charts, ii. sickle cell disease OR iii. congenital or acquired heart disease OR iv. neurodevelopmental disorders, for example, cerebral palsy, OR a medical-related technological dependence, for example, tracheostomy, gastrostomy, or positive pressure ventilation (not related to COVID-19), OR  v. asthma, reactive airway or other chronic respiratory disease o that requires daily medication for control.  Exclusion Criteria  Younger than 12 years of age Do not meet criteria to be classified as "high risk'