Inclusion Criteria:  Sixty adult diabetic patients (type II DM) clinically symptomatized painful neuropathy for six or more months.  Exclusion Criteria:  Patients with other causes of neuropathy (e.g., vitamin B12 deficiency), hereditary neuropathies and entrapment neuropathies, overt neuropathy with foot ulcers and/or amputation, peripheral vascular diseases, vertebral pathologies (e.g., previous surgery, foraminal stenosis, spinal canal stenosis, and/or vertebral disc herniation) Patients with other medical conditions such as connective tissue diseases, thyroid disorders, significant renal or hepatic dysfunction, platelet dysfunction syndrome, critical thrombocytopenia, hemodynamic instability and septicemia local infection at the site of the procedure Consistent use of nonsteroidal anti-inflammatory drugs within the last two weeks Systemic corticosteroid administration or local injection at the suspected treatment site within the last month Recent fever or illness, hemoglobin level <10 g/dL, platelet count <105 _ 109/L, and/or tobacco use.