Inclusion Criteria:  18 years or older Participant in SSP History of self-report injection opioid use in the past 6 months Willing to take bup/nx, PrEP, and/or hepatitis C treatment for 6 months Not currently taking PrEP HIV negative Not pregnant  Either a history of sharing injection or drug preparation equipment or risk of sexual acquisition of HIV* in the past 6 months  *Individuals are considered at risk of sexual acquisition of HIV if they answer yes to any of the items in the below question: In the last 6 months, have any of the following applied to you?  Traded sex for money or drugs Had a sexual partner who is HIV positive Did not consistently use condoms when having sex Had a bacterial sexually transmitted infections (like gonorrhea, chlamydia, or syphilis) No medical contraindications for these medications such as history of renal failure or bone diseases  Exclusion Criteria:  Have altered mental status in which participant cannot sign a consent form Receive a positive pregnancy test (will be checked at screening visit) Receive a positive HIV test at enrollment (will be checked at screening visit) Have evidence of renal failure (will be checked at screening visit) Have a history of hepatitis B (will be checked at screening visit) Becoming incarcerated during the study  Additional considerations:  The following are not exclusion criteria for the study overall, but will affect which treatment(s) they can receive:  Are currently receiving some form of MOUD (buprenorphine, naltrexone, methadone) - this makes them ineligible for MOUD treatment through the study, but they can still receive PrEP and/or hepatitis C treatment Have received treatment for hepatitis C prior to enrollment - this makes them ineligible for hepatitis C treatment through study, but they can still receive PrEP and/or MOUD