Inclusion Criteria:  Patients with jaundice and an injury to the head of the pancreas recommended for EUS-guided tissue acquisition or staging Patients with jaundice and distal CBD lesion suggestive of cholangiocarcinoma or Vater's ampulla carcinoma recommended for EUS-guided tissue acquisition or staging Serum bilirubin level ≥ 3 mg / dl Age ≥ 18 years old Subject affiliated or beneficiary of a social security scheme. Subject having been informed of this study and having given his no objection  Exclusion Criteria:  Presence of altered anatomy due to previous gastric surgery (Billroth II or Roux-en-Y anastomosis) Sphincterotomy performed previously, plastic biliary stent or metal stent placement Percutaneous drainage of the bile ducts performed previously Pregnant, breastfeeding or parturient woman Protected patients: Adults under guardianship, curatorship or other legal protection, deprived of their liberty by judicial or administrative decision; hospitalized without consent.