Inclusion Criteria:  Adults (=/>18 years of age) Able to provide informed consent Clinical indication for cardio-CT in line with the latest clinical guidelines  Exclusion Criteria:  standard contraindications to CT (in line with local roles and guidelines - please see Appendix) known allergy to iodinated contrast agent suspected acute kidney injury unstable hemodynamic status or arrhythmias suspected acute coronary syndrome manifest thyrotoxicosis