Inclusion Criteria:  Between 19 aged and 50 aged in healthy adult Body weight more than 50kg BMI more than 18.0 and under 27.0 Who has negative result on Helicobacter Pylori antibody test  Exclusion Criteria:  Have clinically significant disease that hepatobiliary system, kidney, nervous system, immune system, respiratory system, endocrine system, hemato-oncology disease, cardiovascular system or mental illness, or a history of mental disease Have a gastrointestinal disease history(including surgery) that can effect drug absorption Hypersensitivity reaction of clinically significant hypersensitivity reaction in the history of Esomeprazole, additives or benzimidazole family