Inclusion Criteria:  Aged 18 and more; Scheduled for an elective series of ambulatory ECT sessions at the University Hospital Bern; Informed Consent as documented by signature (Appendix Informed Consent Form).  Exclusion Criteria:  Contraindications to the study drug, e. g. known allergy or hypersensitivity, hypotension, bradycardia, higher grade atrioventricular block; On regular Clonidine for another indication (e.g. arterial hypertension) Patients undergoing emergency ECT; Unable to consent (incapable of judgment, next-of-kin consent necessary or under tutelage); Inability to follow the procedures of the study, e. g. due to language barrier; Previous enrolment into the current study; Participation in another study with investigational drug within the 30 days preceding and during the present study; Enrolment of the investigator, his/her family members, employees and other dependent persons. Women who are pregnant or breast feeding; Intention to become pregnant during the course of the study; Lack of safe contraception, defined as: Female participants of childbearing potential, not using and not willing to continue using a medically reliable method of contraception for the entire study duration (and 4 weeks thereafter), such as oral, injectable, or implantable contraceptives, or intrauterine contraceptive devices, or who are not using any other method considered sufficiently reliable by the investigator in individual cases. Female participants who are surgically sterilised / hysterectomised or post-menopausal for longer than 2 years are not considered as being of child bearing potential.