Inclusion Criteria:  At least 18 years old; Evidence of myocardial ischemia and indications of PCI, stable or unstable angina pectoris, or old myocardial infarction; Primary and bifurcated coronary artery lesions (Medina classification 1,1,1 or 1,0,1 or 0,1,1); Visual angiography of the main branch reference vessel diameter ≥2.5mm, and ≤4.0mm;Branch reference vessel diameter ≥2.0mm; Diameter stenosis of main and branch lesions ≥ 70%, and diameter stenosis of branch lesions ≥ 50%; Visual examination of residual stenosis of main branch lesions after pre-dilation ≤ 30% without vascular dissection or dissection with NHLBI classification A, B, C type. If 2 bifurcation lesions meet the inclusion requirements, only 1 lesion can be included in the study, and the other lesion can be treated or not treated as a non-target lesion.  Exclusion Criteria:  Main branch or branching target lesions require treatment with more than one device (DES or DCB); There is more than 1 non-target lesion requiring intervention on the target blood vessel; The distance between non-target lesion and target lesion is less than 10 mm; Main and branch lesions > 26 mm or branch lesions length BBB> mm; Left main lesion and its bifurcation lesion; Intra-stent restenosis or severe calcification; ST-segment elevation or non-ST-segment elevation myocardial infarction 7 days before surgery; Severe heart failure (NYHA-IV or left ventricular ejection fraction <35%); Cardiogenic shock; known to have renal failure (EGFR <30ml/min/1.73m2); Pregnant or lactating women, or women of reproductive age who had family planning or were unable to take adequate contraceptive measures during the study period; Any known allergic reactions or contraindications to the drug and coating or scaffold metal required for DCB in the study; Other DES or DCB treatment contraindications; Failing to sign an informed consent or having an expected life of less than 12 months; Other researchers consider it inappropriate to participate in this study.