Inclusion Criteria:  Patients with Chronic Kidney Disease (CKD)stage 3b-5 defined as an eGFR( estimated glomerular filtration rate ) of less than 45ml/min/1.73m2 or less will be eligible. Stage 5 CKD will include patients receiving in-center hemodialysis, home dialysis (home hemodialysis or peritoneal dialysis), vaccinated with two doses of the COVID-19 vaccine will be eligible for a third dose to be given 2-12 months following the second dose. Age ≥18 at the time of study enrolment  Exclusion Criteria:  Patients not vaccinated against COVID-19 vaccination. Patients who received heterologous first two doses of vaccine Patients with a severe allergic reaction to prior COVID-19 vaccination or any of the ingredients. New COVID-19 infection