Inclusion Criteria:  receive resective operation with a pathological diagnosis of craniopharyngioma in our hospital enter our hospital between January 2013 and February 2021  Exclusion Criteria:  have a non-craniopharyngioma or unverified pathological diagnosis at discharge have received surgical or radiological treatment on the sellar region receive treatment of coagulation modulation, immunosuppressive agents or chemotherapeutic drugs combine with other clinical emergencies including acute myocardial infarction, cerebral stroke, trauma and sepsis at admission have been diagnosed with other tumors, hematological diseases, autoimmune diseases, liver failure or renal failure