Inclusion Criteria:  Age over 18 years old, no gender limit; A clear diagnosis of chronic systolic heart failure with heart function NYHA III-IV (including medical history, clinical symptoms, and signs) by two attending physicians or above the level of attending ; Left ventricular ejection fraction (LVEF) <40%; Plasma NT-proBNP>1000 ng/L; Participate voluntarily and sign an informed consent form, and can be followed up for more than 6 months.  Exclusion Criteria:  NYHA Class I-II of cardiac function; Acute myocardial infarction occurred in the past month; Unstable angina pectoris; Patients with acute pulmonary edema or acute hemodynamic disturbance; Right heart failure due to lung disease; Patients who are going to undergo heart transplantation or cardiac resynchronization therapy (CRT), or those who have received CRT treatment; Female patients who have or plan to become pregnant; Those who have participated in any drug clinical trials within the previous 3 months; Those who have a history of tumors or are currently suffering from tumors, or pathological examinations have confirmed precancerous lesions (such as ductal carcinoma in situ of the breast, or dysplasia of the cervix); Patients who was detected with a malignant mass in the body through examination (physical examination, or X-ray examination or B-ultrasound examination or other means), or detected with a hyperplastic gland or adenoma that has endocrine activity and affects heart function or endocrine function, such as pheochromocytoma, etc.; The patient refused to comply with the requirements of this research to complete the research work; According to the judgment of the investigator, the patient cannot complete the study or cannot comply with the requirements of the study (due to management reasons or other reasons).