Inclusion Criteria:  patient's age ≥65years prostate cancer robot-assisted laparoscopic radical prostatectomy (RALP)  Exclusion Criteria:  inability to obtain written informed consent history of significant liver, renal or pulmonary diseases current smoking chronic or acute alcoholism known or suspected neuromuscular disorders family history of malignant hyperthermia any pre-existing coagulopathy abnormal blood coagulation tests (including prothrombin time <70%; activated partial thromboplastin time >38 seconds and INR >1.20) or preoperative anticoagulant therapies BMI ≥30 Kg/m2 known allergy or hypersensitivity to the drugs used in the study planned postoperative admission to intensive care unit. moderate neuromuscular block (TOF 1-3) at the end of surgery