Inclusion Criteria:  Male and female, aged between 18 and 75 (inclusive); Subjects who are able and willing to participate in the study; Chronic neuropathic pain with disease duration lasting more than 6 months; The worst NPRS score was ≥ 5 (out of 10), and the subjects reported a similar degree of pain in at least the past two months; Medication-refractory neuropathic pain with resistance to at least three kinds of neuropathic pain prescription drugs and one interventional procedure  Exclusion Criteria:  Craniofacial pain syndrome associated with malignant tumors of the head and neck; Idiopathic trigeminal neuralgia; Headache syndrome, such as migraine; Temporomandibular joint syndrome; Atypical facial pain or pain related to somatoform disorders; Subjects are regarded as unqualified candidates by experts; active mental illness; unstable heart state; severe hypertension (diastolic blood pressure after taking medicine >100mm/Hg) MR imaging standard contraindications, such as non-MRI compatible implanted metal devices, including pacemakers.