Inclusion Criteria:  Diagnosed as mCRPC according to EAU-ESTRO-SIOG 2016 and PSA > 10ng/ml; No previous treatment with novel hormonal therapy; ECOG 0-2; Normal organ function, WBC >= 3000/mm3 or Neutrophil >= 1500/mm3; Aged 18 to 85 years old when issuing written informed consent; Life expectancy > 12 months. Consent and able to carry out follow-up visit and cooperate with all other study procedures.  Exclusion Criteria:  Severe disease or other medical conditions suggesting a high risk of death within 1 year, which may interfere with follow-up. Decided by investigator; Diagnosed with any other malignant tumor within 3 years before enrollment; Unable to provide necessary follow-up information; Other conditions that are judged as ineligible by the investigator.