Inclusion Criteria:  Endovascular therapy were large arterial occlusions proven by MR angiography, Alberta Stroke Program Early CT Score (ASPECTS) >5 on MRI, Baseline National Institutes of Health Stroke Scale (NIHSS) score >5.  If eligible, patients received intravenous thrombolysis (IVT).  Exclusion criteria:  - Vertebro-basilar occlusion