Inclusion Criteria:  People with MS (relapsing-remitting, secondary progressive, primary progressive phenotype) or clinically isolated demyelinating disease syndrome-CIS) according to McDonald's 2001 criteria, consecutively afferent to the outpatient clinic or hospitalized after study approval by the ethics committee.  They:  have never been previously evaluated and/or treated for LUTS secondary to MS; are between 18 and 80 years old; have given written consent to study part.  Exclusion Criteria:  analphabetism; severe cognitive impairment; severe psychiatric pathologies; EDSS> 7; clinical relapse of MS within the previous 30 days; history of urinary fevers > 2 in the last 6 months or > 3 in the last year; indwelling catheter; renal failure (creatinine> 1.2 mg / dL); presence of hydronephrosis, mono or bilateral vesicoureteral reflux; presence of urinary stones; history of urological surgery, neoplasms of the urogenital system and / or pelvic radiotherapy; therapy/treatment for LUTS secondary to MS or other diseases.