Inclusion Criteria:  No age limit, no gender limit; Kidney biopsy confirmed primary IgA nephropathy; Sign the informed consent form voluntarily  Exclusion Criteria:  IgA nephropathy is secondary to systemic diseases such as systemic lupus erythematosus and allergic purpura; IgAN is clinically diagnosed but not confirmed by pathology; The patient refuses to participate; Patients judged by other investigators to be unsuitable for inclusion in the study.