Inclusion Criteria:  Adults aged 18 years or older at the time of enrollment SARS-COV2 positivity by PCR with respiratory failure requiring mechanical ventilation for at least 72 hours Prior therapy with antifungals, including prophylaxis, is NOT an exclusion.  Exclusion Criteria:  Life expectancy of less than 72 hours as determined by the site investigator. Expected to be weaned from mechanical ventilation in next 24 hours Care received in any setting other than an intensive care unit (ICU) at the time of enrollment