Inclusion Criteria:  Clinical diagnosis of atrial fibrillation Disease Age >18years CHA2DS2-VASc scores ≥ 2 And at least one of the following indications: (a) HAS- BLED scores ≥ 3; (b) intolerance to long-term OAC; (c) stroke, TIA or thromboembolism even under OAC treatment  Exclusion Criteria:  GFR <50 mL/min/1.73 m2 Thrombus in LA and LAA