Inclusion Criteria:  Diagnosed with breast cancer More than 18 years old Karnofsky Performance Status (KPS) larger than 80 No clinical or imaging evidence of distant metastasis BMI < 35kg/m2 Patients with no or mild breast ptosis No severe deficiency in hematological, cardiovascular system, no immune-deficiency, no severe abnormal liver or kidney function.  Mental Health Patient  -  Exclusion Criteria:  1. Patients with distant metastasis of breast cancer or local recurrence; 2. Past ipsilateral breast/chest wall radiation; 3. Inflammatory breast cancer, stage IV breast cancer 4. History of severe allergic or specific constitution; 5. Mental illness; 6. Drug/alcohol abuse; 7. Pregnancy, lactation, or impregnated during the trial period; 8. Non-eligible to the study enrollment based on researchers' discretion  -