Inclusion Criteria:  Histologically or cytologically confirmed solid malignancy that is metastatic or unresectable for which standard curative or palliative measures do not exist or are no longer effective (phase Ib) Histologically or cytologically confirmed metastatic or locally advanced solid tumors of the selected indications. (Phase II). .Life expectancy exceeds 12 weeeks; The Eastern Cancer Cooperative Group (ECOG) has a performance score of 0 or 1; Normal organ and marrow function;  Exclusion Criteria:  Has known active central nervous system (CNS) metastases. Subjects with previously treated brain metastases may participate provided they are stable. A history of human immunodeficiency virus (HIV) infection is known, or has an active autoimmune disease. History of interstitial lung disease or pneumonia requiring oral or intravenous steroids. Has moderate or severe cardiovascular disease; Active HBV(hepatitis B) or HCV (Hepatitis C virus)-infected subjects; Any other malignancies within 5 years except for those with negligible risk of metastasis or death.