Inclusion Criteria:  Males and females ASA 1, 2, or 3 No neuropsychiatric conditions Acceptance of informed consent Elective prosthetic hip or knee surgery  Exclusion Criteria:  ASA 4 Present or past neuropsychiatric conditions Hip or knee revision surgery Use of iron as dietary supplement Known erythrocytosis Incompatible hypersensitivities Iron metabolism disorders Lymphoproliferative disorders