Inclusion Criteria:  Adults age 18 years old or older G-tube/G-J tube dependent for medication administration Hypothyroid patients on levothyroxine tablet TSH>5 on levothyroxine  Exclusion Criteria:  J-tube Unstable cardiac condition Unstable gastrointestinal condition Unable to reliably administer medication Screening laboratory value outside of the laboratory normal range that is considered clinically significant for study participation by the investigator. In the opinion of the study investigator, any subject who demonstrate a risk of non-compliance with study procedure, or one who cannot read, understand or complete study - related materials.