Inclusion Criteria  Patients admitted to participating hospital with a clinical diagnosis of acute exacerbation of bronchiectasis (AEB), defined as a change in bronchiectasis treatment associated with deterioration in three or more of the following key symptoms for at least 48 hours: cough; sputum volume and/or consistency; sputum purulence; breathlessness and/or exercise tolerance; fatigue and/or malaise; or haemoptysis. Patients with an established diagnosis of bronchiectasis, defined as the presence of cough, shortness of breath, chronic sputum production, recurrent respiratory infection, or a combination thereof with CT thorax scan confirmation of the presence of bronchiectasis indicated by a bronchoarterial ratio of > 1, lack of tapering, airway visibility within 1 cm of the pleural surface, or a combination thereof.  Exclusion criteria  Patients unable to provide informed consent Age < 18 years Pregnancy Bronchiectasis due to known cystic fibrosis Bronchiectasis is not the main or co-dominant respiratory disease Traction bronchiectasis due to interstitial lung disease Prior lung transplantation for bronchiectasis