Inclusion Criteria:  polymerase chain reaction (PCR) confirmed coronavirus infection (COVID-19) in hospitalized patients with severe risk factors in age from 18 years to 59 years, of both sexes, irrespective of national or ethnic origin the duration of the COVID-19 disease is no more than 10 days informed concent to participate in clinical trials informed concent to to use reliable contraceptive methods while participating in a clinical trial  Exclusion Criteria:  age less than 18 years old and over 59 years old pregnancy or breastfeeding hypersensitivity, allergy, intolerance to iodine, iodine-containing medicines hypersensitivity to Remdesivir or its components impaired consciousness, causing the impossibility of oral administration conditions or circumstances that, in the opinion of the investigator, may affect the patient's safety or the quality of the results obtained participation in another clinical trial, including in the period up to 2 months before this study signs of multiple organ failure alanine aminotransferase (ALT), aspartate aminotransferase (AST) is 5 or more times higher than normal thrombocytopenia below 100 * 10^9/ l decrease in glomerular filtration rate (GFR) less than 30 ml / min by 1.73 m2 chronic heart failure with reduced ejection fraction liver failure coagulopathy mechanical ventilation for 48 hours or more extracorporeal membrane oxygenation (ECMO) disseminated intravascular coagulation