Inclusion Criteria:  Patients diagnosed with non-small cell lung cancer(NSCLC) and scheduled for curative resection. NSCLC with clinical stage Ⅰ-Ⅲ Patients who understood the study and gave written informed consent.  Exclusion Criteria:  Recurred lung cancer Patients with extra-pulmonary synchronous double primary cancer. Patients with history of other cancer diagnosis or treatment in the last 3 years.  Drop Criteria:  When surgery was canceled or pathologic stage IV was confirmed after surgery. Withdrawal informed consent.