Inclusion Criteria:  Malignant-appearing pancreatic mass, or proven pancreatic cancer involving the pancreatic genu, body, or tail  Any level of abdominal or back pain considered to be potentially related to the mass:  New onset pain (<3 months) Constant Centrally located With or without irradiation to the back No obvious other source of pain based on history and physical examination by the attending endosonographer No possibility of surgical management Signed, informed consent Celiac axis accessible for bilateral neurolysis at EUS.  Exclusion Criteria:  1. Allergy to bupivacaine