Pre-Registration Eligibility Criteria:  1. Clinical stage T1-3 N1-2M0 breast cancer at diagnosis (prior to neoadjuvant chemotherapy) by American Joint Committee on Cancer (AJCC) staging 7th edition 2. No inflammatory breast cancer 3. No other malignancy within 5 years of registration with the exception of basal cell or squamous cell carcinoma of the skin treated with local resection only or carcinoma in situ of the cervix 4. All patients must have had an axillary ultrasound with fine needle aspiration (FNA) or core needle biopsy (CNB) of axillary lymph nodes documenting axillary metastasis at the time of diagnosis, prior to or at most 14 days after starting neoadjuvant chemotherapy (NAC)  Note: Biopsy of intramammary nodes does not fulfill eligibility criteria; In some patients, a clip is implanted into positive lymph nodes verified by FNA or CNB under the guidance of ultrasound 5. Patients must have had estrogen receptor, progesterone receptor and HER2 status (by immunohistochemistry [IHC] and/or in situ hybridization [ISH]) evaluated on CNB prior to start of NAC Note: If HER2 status has not been clearly determined (i.e. equivocal/indeterminate), then patients should not be enrolled 6. Patients must have completed all planned cycles and regimens of NAC prior to surgery; sandwich chemotherapy is not allowed (i.e. anthracycline/cytoxan or taxane chemotherapy planned to be given after surgery); patients must have completed at least 4 cycles of NAC consisting of an anthracycline and/or taxane-based regimen without evidence of disease progression in the breast or the lymph nodes Note: Delays/dose modifications due to toxicities/adverse events are allowed as long as a minimum of 4 cycles of NAC is administered; more than 4 cycles of NAC may be administered at the discretion of the treating medical oncologist 7. Patients with HER-2 positive tumors must have received neoadjuvant trastuzumab, or trastuzumab + pertuzumab, or other approved anti-HER-2 therapy (either with all or with a portion of the NAC regimen); therapy must be Food and Drug Administration (FDA)-approved targeted anti-HER2 therapy, but additional therapies are allowed as are non-trastuzumab regimens if administered in the context of an Institutional Review Board (IRB)-approved clinical trial 8. All patients must have a clinically negative axilla (no bulky adenopathy) on physical examination documented at the completion of NAC Note: an ultrasound of the axilla is not required at completion of NAC; if performed, its findings do NOT impact eligibility 9. No more than 8 weeks of neoadjuvant endocrine therapy prior to the start of NAC 10. No neoadjuvant radiation therapy 11. No SLN surgery/excisional biopsy for pathological confirmation of axillary status prior to or during NAC 12. No prior history of ipsilateral breast cancer (invasive disease or ductal carcinoma in situ [DCIS]); lobular carcinoma in situ (LCIS) and benign breast disease is allowed 13. No prior ipsilateral axillary surgery, such as excisional biopsy of lymph node(s) or treatment of hidradenitis 14. No history of prior or concurrent contralateral invasive breast cancer; benign breast disease; LCIS or DCIS of contralateral breast is allowed 15. Patients must not be pregnant or nursing Note: Peri-menopausal women must be amenorrheic for > 12 months to be considered not of childbearing potential 16. Eastern Cooperative Oncology Group (ECOG) (Zubrod) performance status 0-1  Intra-Operative Registration/Randomization Criteria:  Breast surgery (lumpectomy or mastectomy) and SLN or targeted axillary dissection (TAD) surgery must be completed within 30 days of the completion of the last dose of NAC SLNB is rountinely performed after NAC using dual tracer mapping with technetium-99m sulfur colloid and isosulfan blue dye. Radioactive, blue, or palpably abnormal nodes were considered SLNs. In patients presenting with clips, localization of the clipped node was performed and surgeons were aware if the clipped node was retrieved during the SLNB. A minimum of 2 and a maximum of 8 total nodes (sentinel + non-sentinel+/-clipped nodes) are identified and excised; more than 8 biopsied nodes identified by either surgeon or pathologist is not allowed Note: Patients who do not have an identifiable SLN will not be enrolled Zero or one lymph node (sentinel + non-sentinel+/-clipped nodes) excised during SLNB or TAD with a metastasis identified on intra-operative pathologic assessment Note: Nodal macro/micro-metastasis (greater than 0.2 mm in greatest dimension) and isolated tumor cells (metastases less than or equal to 0.2 mm) will be treated as node positive disease (N0i+) Note: If on final pathology, more than 8 lymph nodes are seen pathologically, or two or more than two nodes turn positive pathologically, then the patient should not be recruited into the study. Axillary lymph node dissection (ALND) is not to be performed prior to registration/randomization  Post-Operative Registration/Randomization Criteria:  For cases where ALND has not been performed and one of the following is true: 1) intra-operative evaluation of biopsied lymph node (including sentinel or non-sentinel or targeted nodes) turned to be negative and final pathology identified less than two positive lymph nodes with metastasis OR 2) biopsied lymph node considered negative on intra-operative evaluation was found to be positive on final pathology (only one positive lymph node is allowed) Breast surgery (lumpectomy or mastectomy) and sentinel lymph node surgery must be completed within 30 days of the completion of the last dose of NAC; negative margin (by either breast conservation or mastectomy) on final pathology where negative margin is defined as no tumor on ink For those patients who also undergo contralateral breast surgery, if invasive disease is found in the contralateral breast, the patient is not eligible for registration /randomization