Inclusion Criteria:  1. Western medicine diagnosis is consistent with patients with refractory ulcerative colitis. 2. 18 Years to 65 Years，male or female. 3. Those who voluntarily participate in this clinical study and have signed an informed consent.  Exclusion Criteria:  1. Patients with non-refractory UC. 2. Those who are pregnant or breastfeeding, or have a childbirth plan in the near future. 3. People with severe allergies or allergies to known ingredients in basic treatments. 4. Patients with severe primary diseases such as severe cardiovascular and cerebrovascular diseases, liver and kidney, and hematopoietic system. 5. There are serious complications, such as local stenosis, intestinal obstruction, intestinal perforation, multiple intestinal polyps, toxic megacolon, rectal cancer, etc.. 6. Patients with mental disorders and intellectual disabilities. 7. Patients who have participated in clinical studies of other drugs in the past 3 months. 8. Those who are seriously ill and need emergency treatment. 9. Patients who are still undergoing other treatment options for ulcerative colitis. 10. Researchers believe that it is not suitable for entry.