Inclusion Criteria:  Documented informed consent of the participant and/or legally authorized representative Age between 18 and 54 years Eastern Cooperative Oncology Group (ECOG) =< 2  Histologically confirmed B-cell ALL according to World Health Organization criteria  Note: Lymphoblastic leukemia is included as long as there is bone marrow involvement Newly diagnosed disease with >= 5% blasts in the marrow White blood cell count less than 25 x 10^9/L prior to initiation of venetoclax. Cytoreduction with hydroxyurea or steroid or a single dose of intrathecal chemotherapy prior to treatment may be required (performed within 14 days prior to day 1 of protocol therapy unless otherwise stated) Total bilirubin =< 1.5 X upper limit of normal (ULN) (unless has Gilbert's disease or underlying leukemia, =< 3 X ULN) (performed within 14 days prior to day 1 of protocol therapy unless otherwise stated)  Aspartate aminotransferase (AST) =< 2.5 x ULN (performed within 14 days prior to day 1 of protocol therapy unless otherwise stated)  Unless it is related to underlying leukemia  Alanine aminotransferase (ALT) =< 2.5 x ULN (performed within 14 days prior to day 1 of protocol therapy unless otherwise stated)  Unless it is related to underlying leukemia Creatinine clearance of >= 60 mL/min per 24 hour urine test or the Cockcroft-Gault formula (performed within 14 days prior to day 1 of protocol therapy unless otherwise stated)  Left ventricular ejection fraction (LVEF) >= 50%  Note: Echocardiogram to be performed within 42 days prior to day 1 of protocol therapy  Women of childbearing potential (WOCBP): Negative urine or serum pregnancy test. (performed within 14 days prior to Day 1 of protocol therapy unless otherwise stated)  If the urine test is positive or cannot be confirmed as negative, a serum pregnancy test will be required  Agreement by females and males of childbearing potential* to use an effective method of birth control (non-hormonal) or abstain from heterosexual activity for the course of the study through at least 3 months after the last dose of protocol therapy  Childbearing potential defined as not being surgically sterilized (men and women) or have not been free from menses for > 1 year (women only  Exclusion Criteria:  Leukemia-based therapy with chemotherapy with the exception of:  Cytoreduction with steroid or hydroxyurea or a single dose of intrathecal chemotherapy is allowed before initiating the study Strong or moderate CYP3A4 inducers within 14 days prior to day 1 of protocol therapy Subjects who have consumed grapefruit, grapefruit products, Seville oranges (including marmalade containing Seville oranges) or Star fruit within 3 days prior to the first dose of study drug Live vaccines Philadelphia chromosome positive (Ph+; t(9;22)), MLL-rearrangement, t(12;21), and t(1;19) T cell ALL Class III/IV cardiovascular disability according to the New York Heart Association Classification. Subjects with controlled, asymptomatic atrial fibrillation can enroll Parenchymal central nervous system (CNS) involvement requiring cranial radiation Participants with clinically significant arrhythmia or arrhythmias not stable on medical management within two weeks of enrollment History of acute cardiovascular ischemic event, i.e., myocardial infarction or unstable angina within 6 months of enrollment History of allergic reactions attributed to compounds of similar chemical or biologic composition to study agent Clinically significant uncontrolled illness Uncontrolled active infection Other active malignancy Females only: Pregnant or breastfeeding Any other condition that would, in the Investigator's judgment, contraindicate the patient's participation in the clinical study due to safety concerns with clinical study procedures Prospective participants who, in the opinion of the investigator, may not be able to comply with all study procedures (including compliance issues related to feasibility/logistics)