Inclusion Criteria:  "Case" Patient :  with nephronophthisis or ciliopathy with known genetic diagnosis or not signed the Informed consent form (patient or legal guardians if minor/incapable major) no limit of age, this patients could be recruited from the birth social insurance affiliation  Healthy related individual :  related with a included patient (father, mother, brother, sister) signed the Informed consent form (major or legal guardians if minor/incapable major) no limit of age, this patients could be recruited from the birth social insurance affiliation  "Negative Control" patient :  without chronic renal failure signed the Informed consent form (major or legal guardians if minor/incapable major) no limit of age, this patients could be recruited from the birth social insurance affiliation  "Positive Control" patient :  with chronic renal failure not related with a ciliary dysfunction signed the Informed consent form (major or legal guardians if minor/incapable major) no limit of age, this patients could be recruited from the birth social insurance affiliation  Exclusion Criteria "Case" Patient :  pregnant, parturious and nursing mothers. with functional renal graft use an experimental treatment during 30 days before inclusion date  Healthy related individual :  - pregnant, parturious and nursing mothers.  "Negative Control" patient :  - pregnant, parturious and nursing mothers.  "Positive Control" patient :  pregnant, parturious and nursing mothers. with functional renal graft use an experimental treatment during 30 days before inclusion date