Inclusion Criteria:  To be over 18 years old. Be in good general health. Have at least one monoradicular tooth (premolar, canine or incisor) that must be extracted with the need for bone regeneration and one or more implants afterwards. Have a DPSI (Dutch Periodontal Screening Index) ≤ 2.  Exclusion Criteria:  Being a smoker. Have "active" periodontal problems, have a DPSI > 2. Have a contraindication to the insertion of an implant and/or oral surgery. Have an active inflammatory and/or autoimmune disease of the oral cavity. Treatment with immunosuppressants, corticosteroids or biphosphonates. Have a history of cancer, radiotherapy or chemotherapy for cancer within the last 5 years. Have insulin-dependent diabetes. Have a blood disorder.