Inclusion Criteria:  Cystic fibrosis Liver disease detected by an abnormal physical examination (hepatomegaly or splenomegaly, confirmed on US), abnormalities of liver function tests (increase of AST, ALT, GGT levels above the upper normal limits) or ultrasonographic evidence of liver involvement (US liver score ≥ 5). Indirect signs of portal hypertension on Doppler US Progressive portal hypertension / liver disease on bi-monthly follow-up, evaluated by physical examination, blood analysis and US  Exclusion Criteria:  Cirrhosis on biopsy Symptomatic portal hypertension (Portosytemic pressure gradient > 10 mmHg)