Inclusion Criteria:  adult patient, aged 18 year or older under mechanical ventilation and continuous general anesthesia, with a positive end-expiratory pressure of 5 cmH2O or more with stage 3 KDIGO acute kidney injury treated with continuous renal replacement therapy for less than 14 days ongoing continuous cardiac output monitoring with a predicted intensive care length of stay of 24 hours or more at time of screening  Exclusion Criteria:  High arterial lactate concentration, > 4.0 mmol/L at time of screening Calibrated cardiac index < 2.0 L/min/m2 or > 4.0 L/min/m2 at time of screening Positive postural change maneuver in the last 2 hours preceding screening Patient under extracorporeal membrane oxygenation Patient with active bleeding requiring emergent transfusion Patient under chronic maintenance dialysis or renal transplant recipient Acute ischemic or hemorrhagic stroke complicated with coma and requiring mechanical ventilation Fulminant hepatitis (acute liver injury, hepatic encephalopathy, icterus and a drop in prothrombin < 50% in less that 15 days Impossible postural change maneuver Pregnant or lactating patient Imminent death Patient under legal protection measures as by French regulation Patient already enrolled in the present study Patient already participates in a study with protocolized net ultrafiltration, ongoing at time of screening