Inclusion Criteria:  Age above 18 years and less than 60 years Patients diagnosed as HIV infection with viral inhibition or preparing to start antivirus therapy were included . The functions of multi-organs were normal or basically normal, and there are no contraindications for vaccination.  Exclusion Criteria:  Patients with acute attack of chronic diseases. Patients have history of convulsion, epilepsy, encephalopathy and psychosis. Patients who are allergic to any component of the vaccine, or have a serious history of vaccine allergy. Pregnant or lactating women. Suffering serious cardiovascular diseases, such as arrhythmia, conduction block, myocardial infarction, and severe hypertension can not be well controlled by drugs. Patients have severe chronic diseases or diseases can not be controlled well during the progress, such as asthma, diabetes, thyroid disease, etc. Congenital or acquired angioedema / uroedema. Patients who are receiving immunosuppressants such as glucocorticoid.