Key Inclusion Criteria:  Documented history of HTG-associated AP within 15 months of screening Fasting serum TG value >880 mg/dL (10 mmol/L) on 2 occasions at least 2 days apart determined during the screening period. Stable dose of lipid-lowering therapy (≥8 weeks) and willingness to maintain a stable regimen throughout the study Body mass index ≥18.0 and ≤40.0 kg/m2 Compliance with a stable diet and exercise regimen at screening and willingness to continue the diet through the end of the study  Key Exclusion Criteria:  Hospitalization for AP within 4 weeks of screening Known genetic FCS defined as homozygous or compound heterozygous LoF mutations in LPL as defined in the protocol Symptomatic gallstone disease within 6 months prior to screening as defined in the protocol Use of any medication or nutraceutical known to alter serum lipids which has not been part of a stable therapeutic regimen for at least 8 weeks, and there are no plans to change the regimen during the study Presence of any clinically significant, uncontrolled endocrine disease known to influence serum lipids as defined in the protocol  Note: Other protocol-defined Inclusion/ Exclusion Criteria apply