Inclusion Criteria:  Medical diagnosis for uni or bilateral OA of the tibiofemoral joint (grade II or superior Kellgren-Lawrence radiographic changes); Not having systemic rheumatic diseases such as fibromyalgia, rheumatoid arthritis, systemic lupus erythematosus; Not having total knee arthroplasty, knee ligament injury, history of knee surgery; Not having heart disease, congestive heart failure, or a history of acute myocardial infarction (except those with hypertension); Not having diagnosis of neurological, metabolic, endocrine disorder, respiratory disease; Not being an alcoholic or smoker; Not use drugs that influence cardiac autonomic modulation (beta-blocker); Not having one or more predisposing risk factors for thromboembolism.  Exclusion Criteria:  Use anti-inflammatory drugs or analgesics 24 hours before the test; Perform physical activity; Consume alcohol; Perform therapeutic treatments for pain relief; Errors in capturing the RR intervals; Want to leave the study.