Inclusion Criteria:  Pathologically confirmed measurable basal cell carcinoma (BCC) or well to moderately differentiated squamous cell carcinoma (SCC) Age 18 years or older Able to provide informed consent  Exclusion Criteria:  Lesion with indistinct borders Any evidence of metastatic disease Poor performance status (Eastern Cooperative Oncology Group > 1) with life expectancy of less than 2 years Gorlins syndrome, a genetic predisposition to multiple skin cancers where surveillance and early intervention is of paramount importance Any recurrent cancer after surgery or radiation Very extensive carcinoma that cannot be readily removed by surgery or treated by radiation using orthovoltage or electron beam History of cutaneous photosensitization, porphyria or photodimerization as their tolerance to hydrogen peroxide application is unpredictable Previous application of 5-Fluorouracil cream to the lesion within the last 8 weeks Any immune-compromised patients where skin cancers can be very aggressive Patients who are unwilling to return for 1-year follow-up assessment Poorly differentiated SCC