Inclusion Criteria:  Age 19-80 years at screening nonsmoker After fully hearing and fully understanding this clinical trials, those who agree to voluntarily decide to participate and to comply with the notice  Exclusion Criteria:  Participants with clinically significant severe cardiovascular, endocrine, immune, respiratory, liver, biliary, renal and urinary tract, neuropsychiatry, musculoskeletal, inflammatory and hematologic and gastrointestinal disorders Participants who have Body Mass Index(BMI) less than 18.5 kg/m^2 or more than 35 kg/m^2 Participants who have taken medication or dietary supplements related to the respiratory disease within 1 months prior to screening Participants with a history of antipsychotic medication use within 3 months prior to the screening examination Participants who alcoholic or drug abuse suspected Participants who have participated in the other human trials within 3 months before the screening test  Laboratory test by show the following results  AST, ALT > Reference range 3 times upper limit Serum Creatinine > 2.0 mg/dL Pregnancy or breast feeding Patients who are judged ineligible to participate in the trial by the principal investigator for other reasons, including laboratory test outcomes