Inclusion Criteria:  The patient was diagnosed with breast cancer.; Breast cancer patients diagnosed with cancer related fatigue are included in our clinical study; Voluntarily participate in the clinical trial and sign the informed consent form after informed consent (patients voluntarily accept the treatment and give informed consent); Patients with previous local recurrence were eligible, but not patients with distant metastasis； The basic indexes were consistent, and the blood routine and ECG were normal.  Exclusion Criteria:  The exclusion criteria were patients with needle phobia; Low platelet count (<50 000); co-morbidity with a bleeding disorder; co-morbidity with thyroid dysfunction; pregnancy; haemoglobin levels <10 g/dl and haematocrit <30; anaemia on active pharmacological treatment or receiving blood transfusion or steroids； Life expectancy <6 months； lymphoedematous limbs.