INCLUSION CRITERIA  General inclusion criteria:  Age 18 years or older. Willing to provide written informed consent and written HIPAA authorization prior to initiation of study-related procedures. Agree to not participate in any other clinical study during hospitalization for the index procedure that would interfere with the endpoints of this study. Clinical evidence of ischemic heart disease, stable/unstable angina, or silent ischemia.  Acceptable candidate for PCI and emergency coronary artery bypass grafting and is planned for possible PTCA and/or stent placement.  Angiographic inclusion criteria:  De novo or restenotic lesion(s) in native coronary arteries, including in-stent restenosis.  A maximum of two lesions, including at least one target lesion, in single or double vessel coronary artery disease.  If two target lesions are defined, then no non-target lesions can be treated. If a single target lesion is defined, then a single non-target lesion may be treated, but if so, it must be located in a different coronary artery from the target lesion. Target lesion(s) must have a reference vessel diameter between 2.0 mm and 4.0 mm by visual estimation. Target lesion(s) must have a diameter stenosis of (a) ≥70% by visual estimation or (b) >50% by visual estimation and a fractional flow reserve (FFR) of <0.80 or resting full-cycle ratio (RFR) or instantaneous wave-free ratio (iFR) <0.9. Treatment of non-target lesion, if any, must be completed prior to treatment of target lesion; must not, in the opinion of the investigator, impact the conduct or completion of the index procedure; and must be deemed a clinical angiographic success as visually assessed by the investigator.  EXLUSION CRITERIA  General exclusion criteria:  Known hypersensitivity or contraindication to aspirin, heparin, bivalirudin, anti-platelet medications, a clopidogrel non-responder, or sensitivity to contrast media that cannot be adequately pre-medicated or replaced with a clinically suitable alternative. Known diagnosis of type I myocardial infarction (resulting from primary reduction of flow from a culprit lesion likely to have a thrombotic component) within 7 days prior to the index procedure. Known pregnancy or is nursing. Women of child-bearing potential should have a documented negative pregnancy test within 7 days prior to index procedure. Planned target lesion treatment with atherectomy (rotational, orbital or laser), cutting balloon, thrombectomy, lithotripsy or an unapproved device during the index procedure. Serum creatinine >2.0 mg/dl within 7 days prior to the index procedure. Cerebrovascular accident within 6 months prior to the index procedure. Active peptic ulcer or active gastrointestinal bleeding within 6 months prior to the index procedure. Left ventricular ejection fraction <30% based on most recent measurement within a year of the index procedure (if LVEF is not available in the medical records, it may be obtained at the time of the index procedure, prior to enrollment). Target lesion located within a bypass graft (venous or arterial) or graft anastomosis. Previous percutaneous intervention, within 9 months before the study procedure, on lesions in a target vessel (including side branches) that are located within 10 mm from the current target lesion(s). Target lesion(s) with complete total occlusion defined as the complete obstruction of a native coronary artery, exhibiting TIMI 0 or TIMI 1 flow, with an occlusion duration of at least 3 months. Unstable hemodynamics or shock.  Other medical condition which might, in the opinion of the investigator, put the patient at risk or confound the results of the study.  Angiographic exclusion criteria  Target lesion(s) longer than 32 mm by visual estimation. Extreme angulation (90º or greater) within 5 mm of the target lesion. Target lesion(s) demonstrating flow limiting dissection (NHLBI Grade C or higher) prior to deployment of the Lacrosse NSE ALPHA. Unprotected left main coronary artery disease (>50% diameter stenosis). Coronary artery spasm of the target vessel in the absence of a significant stenosis. Target lesion(s) with angiographic presence of probable or definite thrombus. Target lesion(s) involves a bifurcation requiring treatment with more than one stent or pre-dilatation of a side branch >2.0 mm in diameter. Target lesion(s) located in bifurcation beyond stent struts. Target lesion(s) located distal to an implanted stent. Target lesion(s) with stent damage.  Non-target lesion that meets any of the following criteria:  Located within a bypass graft (venous or arterial) Located in an unprotected left main coronary artery A CTO Involves a bifurcation