Inclusion Criteria:  The patient has reviewed the ethics-approved consent form and has provided consent for data collection Subject is a female over the age of 18 at the time of index surgery (mastectomy) Subject had mastectomy performed for cancer or as a cancer prophylaxis  The surgical plan included one of the following approaches:  Immediate unilateral or bilateral prepectoral DTI or TE/I breast reconstruction following nipple-sparing, skin-sparing, or skinreducing mastectomy with the use of SurgiMend® PRS or SurgiMend® PRS Meshed Immediate unilateral or bilateral submuscular DTI or TE/I breast reconstruction following nipple-sparing, skin-sparing, or skin-reducing mastectomy with the use of SurgiMend® PRS or SurgiMend® PRS Meshed If subject received bilateral breast reconstruction, the subject must have received the same surgical technique for both breasts including the implantation of SurgiMend® PRS or SurgiMend® PRS Meshed If subject received unilateral breast reconstruction, there was no surgical intervention on the contralateral breast within 12 months post-operatively Subject underwent mastectomy (index surgery) at a minimum of 24 months prior to study initiation at site  Exclusion Criteria:  The surgical plan included muscle flaps to supplement the breast mound The reconstruction plan included hybrid implant coverage with another type of mesh (e.g., use of another mesh or ADM in addition to SurgiMend®) Subject had received prior breast augmentation, mastopexy, or breast reduction surgeries (does not include breast biopsy) Subject was a user of any nicotine products (cigarettes, chewing tobacco, vapor, etc.) (within 6 weeks before index surgery) Subject had uncontrolled Type I or Type II diabetes (HbA1C >9) Subject had previously undergone radiation therapy to the chest wall prior to index surgery Subject had been diagnosed with advanced stage disease (stage 3 or 4, or inflammatory cancer)