Inclusion Criteria:  Patient must be ≤ 18 years at the time of diagnosis Newly diagnosed patients with histologically confirmed high-risk anaplastic large cell lymphoma No congenital immunodeficiency, HIV infection, or prior organ transplant  Exclusion Criteria:  Patients have received prior cytotoxic chemotherapy/target therapy/radiation, if any steroid applied, total prior steroids dosage > Dexamethasone 40 mg/m2 for the current diagnosis or any cancer Patients have overwhelming infection, and a life expectancy of < 2 weeks