Inclusion Criteria:  Male or female 40 - 80 years of age Receiving care at Intermountain Medical Center At higher than typical risk for cardiovascular events, as assessed by the Principal Investigator or his/her delegate (further defined in the protocol) Currently not pregnant Ability to understand and sign a written informed consent form which must be obtained prior to initiation of any study procedures Willing and able to comply with any virtual or in-person follow-up visits, tests, and schedule of evaluations Willing and able to undergo a blood draw for SomaSignal Tests Willing and able to provide access to their electronic health records  Exclusion Criteria:  Presence of Systemic Lupus Erythematosus Inability to communicate appropriately Participation in any other clinical trials involving investigational or marketed products within 30 days prior to entry in the study Other conditions that in the opinion of the Principal Investigator and/or Co-Principal Investigators may increase risk to the participants and/or compromise the quality of the clinical trial The Principal Investigator and/or Co-Principal Investigator determine(s) that the participant is not eligible for participation in this research study.