Inclusion Criteria:  Patients with degenerative ankle cartilage disease; Unilateral involvement on the ankle; Signs and symptoms of degenerative pathology of the ankle cartilage; Radiographic or MRI signs of degenerative pathology of the ankle cartilage (OA Van Dijk grade 1-3); No clinically significant electrocardiographic changes (recently performed ECG). Ability and consent of patients to actively participate in clinical follow-up;  Exclusion Criteria:  Patients unable to give consent; Patients who have undergone intra-articular infiltration of another substance in the preceding 6 months; Patients who have undergone ankle surgery in the preceding 12 months; Patients with malignant neoplasms; Patients with rheumatic diseases; Patients with uncompensated diabetes;  9. Patients with uncompensated thyroid metabolic disorders; 10. Patients who abuse alcoholic beverages, drugs or medications; 11. Body Mass Index > 35;