Inclusion Criteria:  Age ≥ 16 years old and ≤ 75 years Patients diagnosed with adrenal associated diseases, including cushing syndrome, primary aldosteronism, primary hypoadrenalism, congenital adrenal hyperplasia and adrenal adenomas, incidentalomas, and carcinomas, pheochromocytoma, etc. Provide written informed consent Satisfactory compliance  Exclusion Criteria:  Patients with significantly reduced life expectancy (less than 2 years) With Drug abuse With AIDS or syphilis or infectious diseases such as viral tuberculosis in active phase at enrollment