Inclusion Criteria:  18-65 years old Experience a severe burn injury that warrant laser therapy. Free of any significant underlying medical problems based upon a detailed medical history and physical exam  Exclusion Criteria:  Known heart disease Other chronic medical conditions requiring regular medical therapy including cancer, diabetes, uncontrolled hypertension, and uncontrolled hypercholesterolemia. Abnormality detected on routine screening suggestive of cardiac ischemia or previously undetected cardiac disease or resting left bundle branch block on screening electrocardiogram. Subject with a body mass index >35 kg/m2 Pregnant or planning to become pregnant within the subsequent 6 months.