Inclusion Criteria:  Age ≧ 20 Both gender are accepted Subject with at least three epidermal pigmented lesions on face The diameter of solar lentigo are ≦ 0.5*0.5 cm2 Fitzpatrick skin Type III or IV Subject having lentigos graded 5 or more on the severity grading scale Clinically and dermoscopic confirmed epidermal pigmented lesions on the face which were no treated in the last 12 months Accepts not to expose the face to sunlight or artificial UV rays during the study Is willing to comply with all requirements of the study including being photographed, following post treatment care and attending all treatment and follow up visits  Exclusion Criteria:  Simultaneous use of other topical skin lightening Refuses to comply the requirements during the study Pregnant woman or woman wishing to be pregnant during the study, or during breastfeeding period Has any condition which, in the investigator's opinion, would make it unsafe for participating in this research study Has systemic skin disorders or infections Is enrolled or accepted other investigational drug or medical device