Inclusion Criteria:  It conforms to the western diagnostic criteria of plaque psoriasis and the diagnostic criteria of TCM syndrome of blood heat syndrome; Physician global assessment (PGA) ≥3, psoriasis area and severity index (PASI) score ≥12, and body surface area (BSA) ≥ 10% at screening and baseline; Aged between 18 and 70; Those who voluntarily participate in the study and sign the informed consent.  Exclusion Criteria:  Erythrodermic psoriasis patients, arthropathic psoriasis patients, pustular psoriasis patients; There are other active skin diseases that may affect the evaluator; Have systematically received other investigational drugs within 1 month; Received external glucocorticoid and phototherapy within 2 weeks; During a period of severe and uncontrollable local or systemic acute or chronic infection; Infected persons with tuberculosis; Patients with viral hepatitis; Serious systemic disease; Or clinical test indicators belong to one of the following cases of patients: alanine aminotransferase or glutamic-oxalacetic transaminase increase > 1.5 times the upper limit of normal value; Creatinine increase > 1.5 times the upper limit of normal value; Any one of the major blood routine indicators (white blood cell count, red blood cell count, hemoglobin amount, platelet count) is lower than the lower limit of normal value; Or other abnormal laboratory tests determined by the investigator to be unsuitable for the study; Patients with a history of malignant tumor and patients with primary or secondary immune deficiency and hypersensitivity; Participants in clinical trials of other drugs within 3 months; Those who have undergone major surgery within 8 weeks or will require such surgery during the study period; For fertile women of childbearing age who did not use highly effective contraception from the screening period until the end of the last dose; Pregnant or lactating women; Persons with a history of alcohol, drug or substance abuse; Persons with a serious history of mental illness or family history; For other reasons, the researcher considers it inappropriate to participate in this study.