Inclusion Criteria:  Healthy caucasian men and women aged between 18 to 45 years Verified diagnosis "healthy" according to the anamnesis data and the results of standard clinical, laboratory and instrumental examination methods, physical examination and anamnestic examination Body mass index 18.5-30 kg/m² according to Quetelet's weight-height index The results of an X-ray or fluorographic examination of the chest organs within the normal range (the results of an examination carried out within 12 months before the start of the study may be provided)  For female subject:  the results of the examination of the mammary glands (palpation or mammography) within the normal range according to the data obtained within 12 months before the start of the study; non-breastfeeding women, negative pregnancy test and the consent to adhere to adequate methods of contraception from the moment of signing the informed consent form and up to 30 days after taking the drug in the second period of the study; reliable methods of contraception: sexual continence, or condom + spermicide, or diaphragm + spermicide, started at least 14 days before the first dose of the study drug; intrauterine contraception is also a reliable method of contraception, installed at least 4 weeks before taking the study drugs in the first period; in case of using hormonal contraceptives, the latter should be canceled at least 2 months before taking the drug in the first period; women who do not use acceptable methods of contraception, if they are considered incapable of childbearing, will also be able to participate in the study: women who have undergone a hysterectomy or tubal ligation, women with a clinical diagnosis of infertility, and women who are in menopause (at least a year without menstruation in the absence of alternative pathologies that may cause the cessation of menstruation). For male: consent to use a double barrier method of contraception (condom + spermicide) or complete sexual abstinence, as well as consent not to participate in sperm donation during the entire study and 90 days after taking the drug in the second period Subjects are able to understand the requirements of the study, to sign a written informed consent, and also to accept all the restrictions imposed during the course of the study, and to agree to return for the required investigations  Exclusion Criteria:  burdened allergic history, hypersensitivity to torasemide or excipients that are part of any of the investigational drugs, or intolerance to these components; clinically significant pathologies of the cardiovascular, bronchopulmonary, neuroendocrine systems, as well as diseases of the gastrointestinal tract, liver, kidneys and blood; other diseases that, in the opinion of the researcher, may affect the absorption, distribution, metabolism or excretion of both drugs, or increase the risk of negative consequences for the volunteer; the presence of mental disorders, including a history; surgical interventions on the gastrointestinal tract, with the exception of appendectomy; acute infectious diseases that ended less than 4 weeks before taking the drug in the first period; dehydration due to diarrhea, vomiting or other reason within the last 24 hours before taking the drug in the first period of the study; clinically significant abnormalities on the ECG, the level of systolic blood pressure (SBP) measured in the sitting position at the time of screening ≤ 100 mm Hg or ≥ 130 mm Hg and / or diastolic blood pressure (DBP) ≤ 60 mm Hg or ≥ 85 mm Hg; heart rate less than 60 beats/min or more than 90 beats/min at the time of screening, respiratory rate less than 12 or more than 18 per minute at the time of screening, body temperature below 36.0 ° C or above 37.0 °C at the time of screening; the use of injectable and oral hormonal contraceptives, subcutaneous hormonal implants or intrauterine hormonal therapeutic systems and other hormonal contraceptives for 60 days before taking the drug in the first period; use of well-known inhibitors or inducers of liver microsomal enzymes less than 30 days before enrollment in the study; use of any drugs including herbs and food additives, vitamins that can have a significant effect on the PK of torasemide or data on the effect of which on the pharmacokinetics of torasemide are unknown, as well as question the characterization of the volunteer as healthy, less than 14 days before taking the drug in the first period; donation of plasma or blood (450 ml or more) less than 2 months (60 days) before taking the drug in the first period; consumption of caffeine and xanthine-containing drinks and products (tea, coffee, chocolate, cola, etc.), products containing poppy seeds, less than 48 hours before taking the drug in the first period; consumption of alcohol and alcohol-containing foods and beverages less than 48 hours before taking the drug in the first period; use of citrus fruits (including grapefruit and grapefruit juice) and cranberries (including juices, fruit drinks, etc.) less than 7 days before taking the drug in the first period; intake of more than 10 units alcohol per week (1 unit of alcohol is equivalent to 500 ml of beer, 200 ml of dry wine or 50 ml of spirits ethyl 40%) or history of alcoholism, drug addiction, drug abuse; smoking more than 10 cigarettes per day less than 48 hours before taking the drug in the first period; inability to refrain from intensive physical activity and contact sports less than 24 hours before taking the drug in the first period; participation in other clinical trials of drugs less than 3 months before taking the drug in the first period; test positive for syphilis, hepatitis B, hepatitis C or HIV at the time of screening; positive pregnancy test at screening; breastfeeding; positive test for alcohol in exhaled air at screening; positive urinalysis for the content of narcotic and potent substances during screening (opiates, morphine, barbiturates, benzodiazepines, cannabinoids/marijuana); the value of standard laboratory and instrumental parameters that go beyond the reference values; lack of intention of volunteers to comply with the Protocol requirements throughout the course of the study and/or lack, in the opinion of the Investigator, of the volunteers' ability to understand and evaluate the information on this study as part of the informed consent form signing process, in particular regarding the expected risks and possible discomfort; tattooing and piercing within 30 days prior to first drug administration; difficulty swallowing tablets; a history of lactase deficiency, galactose intolerance, glucose/galactose malabsorption (the tablets of the tested and reference drugs contain lactose); difficulty with taking blood (for example, difficult access to the veins); using special diets (eg fasting, etc.) or diets (eg, protein, vegetarian, vegan, etc.).