Inclusion Criteria:  Systemically healthy males and females ≥18 years old Willingness to read and sign a copy of the Informed Consent Form after reading the Patient Information Sheet, and after the nature of the study has been fully explained Clinical evidence of periodontitis, defined as the presence of interdental clinical attachment loss detectable at ≥2 non-adjacent teeth or buccal or oral clinical attachment loss ≥3mm with pocketing >3 mm detectable at ≥2 teeth (Tonetti et al., 2018) Not having received subgingival instrumentation within the previous 12 months  Exclusion Criteria:  Medical history that includes serious medical conditions or transmittable diseases (e.g. serious cardiovascular disease, organ transplant, renal failure, AIDS, viral etc.). Antibiotic, anti-inflammatory or anticoagulant therapy during the month preceding the baseline exam. In treatment with drugs that induce gingival overgrowth History of conditions requiring prophylactic antibiotic coverage prior to invasive dental procedures History of alcohol or drug abuse. Self-reported pregnancy or lactation (this criterion is due to oral tissue changes related to pregnancy and nursing, which can affect interpretation of study results). Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with trial participation or investigational product administration or may interfere with the interpretation of trial results and, in the judgement of the investigator, would make the subject inappropriate for entry into this trial.