Inclusion Criteria:  Age ≥ 18 years old Patient with type 2 diabetes, treated with basal insulin plus metformin (maximum tolerated dosage) for at least 12 weeks Patient accepting to participant to this study  Exclusion Criteria:  Pregnant or breastfeeding woman severe renal dysfunction (eGFR <60 ml/min/1.73m2) chronic or acute hepatic disorder (HBV or HCV hepatitis, liver cirrhosis etc.) (AST/ALT > 2.5*ULN) Prescription such as immunosuppressant agents, glucocorticoids Active anti-cancer treatment