Key Inclusion Criteria:  Able to understand and sign an Informed Consent Form that been approved by an Institutional Review Board. Successful wear of spherical soft contact lenses in both eyes for a minimum of 5 days per week and 10 hours per day during the past 3 months. Willing to wear study contact lenses for at least 16 hours prior to the follow up visits. Other protocol-defined inclusion criteria may apply.  Key Exclusion Criteria:  Current/previous PRECISION1 or INFUSE contact lens wearer. Any eye condition or use of medication that contraindicates contact lens wear, as determined by the investigator. Routinely sleeps in contact lenses. Other protocol-defined exclusion criteria may apply.