Inclusion Criteria:  Confirmed diagnosis of iSS (superficial siderosis of the CNS)  No illegal drug use  No history of myocardial infarction or stroke  No history of severe chronic obstructive pulmonary disease  Can safely swallow large capsules  Exhibits at least one confirmed iSS related symptom: Hearing Loss, Balance, Memory/Cognitive problems  Does not have a known hypersensitivity or intolerance to any study antioxidant  Has not taken part in another treatment study for any condition within the last 30 days (about four and a half weeks)  Not currently pregnant or breastfeeding  Exclusion Criteria:  Inosine Arm Exclusion :  Diagnosed with urate urolithiasis, or recurrent urolithiasis, all unknown type  History of Gout  History of Kidney Stones  P6 Arm Exclusion  Long-term anticoagulant  Known or suspected active bleed into the CNS  Currently undergoing deferiprone chelation therapy  Plan to begin deferiprone chelation therapy within three years  -