Inclusion Criteria:  Patient age between 18 and 75 Signed Informed Consent Form. Confirmed TNM stage is III-Ⅳ of NSCLC ，and failed, refused or assessed ineligible to receive conventional treatments (surgery, chemoradiotherapy, Chemotherapy)； Eastern Cooperative Oncology Group (ECOG) performance status ≤ 1 Adequate hematologic and end-organ function. Expected life span > 3 months. Be able to provide fresh or archival tumor tissues for PD-L1 expression in tumor cells  Exclusion Criteria:  Prior therapies of docetaxel or treatment targeting PD-1, PD-L1 or CTLA-4. Prior therapies of interventional therapy (I seeds implantation, Ablation, BACE). Harboring EGFR sensitizing mutation or ALK gene translocation History of interstitial lung disease, non-infectious pneumonitis or participants with significantly impaired pulmonary function, or who require supplemental oxygen at baseline. With uncontrollable pleural effusion, pericardial effusion, or clinically significant ascites requiring interventional treatment. Symptomatic central nervous system metastasis Known HIV infection, participants with untreated chronic hepatitis B, active vaccination treatment. Prior allogeneic stem cell transplantation or organ transplantation Active autoimmune diseases or history of autoimmune diseases that may relapse. With conditions requiring systemic treatment with either corticosteroids (>10 mg daily prednisone or equivalent) or other immunosuppressive medications Known to be hypersensitive to contrast agent; Pregnant or breastfeeding women; Other protocol defined Inclusion/Exclusion criteria may apply