Inclusion Criteria:  Pregnant woman aged 20 to 35 years old 24-26 week of gestation HBsAg positive more than 6 months and HBeAg positive HBV DNA> 200,000 IU/ml Informed consent is signed voluntarily by both husband and wife Good compliance and able to be followed up as planned  Exclusion Criteria:  Mothers co-infected with HCV and HIV Evidence of decompensated cirrhosis and liver cancer Mothers had other organ lesions which would affect patient compliance and follow-up plan Mothers had history of spontaneous abortion or their children had birth defect or congenital malformation Mothers received antiviral therapy within 6 months Mothers had history of kidney injury, CCr <50ml/min and urine protein test positive (>300mg/L) Mothers had history of other chronic diseases and had to take immunomodulators, cytotoxic drugs or hormonal drugs during pregnancy The infants' biological fathers are infected with HBV Symptoms of threatened abortion during early pregnancy ALT > 1×upper limit of normal (ULN), or TBIL ≥ 1×ULN or glomerular filtration rate (GFR) < 90 ml/min, or Albumin (ALB) < 25 g/L Fetal malformations detected by B-ultrasound during pregnancy Participating in other studies