Inclusion Criteria:  Males and females between 40 and 75 years of age Body mass index (BMI) < 40 kg/m2 Diagnosis of primary tibiofemoral knee OA by standard American College of Rheumatology clinical and radiographic criteria and other criteria as specified by the protocol  Exclusion Criteria:  Participants with radiographic knee OA K-L grade = 4 on the non-target knee Arthroscopy of the target knee within the 6 months prior to Screening Hemoglobin < 8.5 g/dL (85 g/L) or platelet count < 100,000/μL and other criteria as specified by the protocol