Inclusion Criteria:  Age ≥ 18 years. Chest pain or other complaints suspect of ACS for at least 2 hours where the GP or emergency medical personnel are in need of further diagnostics or risk stratification to come to a decision of referral. Patients, who have been informed of the nature of the study, agree to its provisions and have provided written informed consent.  Exclusion Criteria:  Electrocardiographic ST-segment elevation/High suspicion of STE-ACS. Suspicion of an acute non-coronary diagnosis e.g. pulmonary embolism, thoracic aortic dissection or other life-threatening disease. Patients presenting cardiogenic shock, defined as: systolic blood pressure <90mmHg and heart rate >100 and peripheral oxygen saturation <90% (without oxygen administration) Patients presenting with sudden onset heart rhythm disorders and second or third degree atrioventricular block. Patients with confirmed ACS, PCI or CABG <30 days prior to inclusion. Impaired consciousness defined as an EMV <8. Severe shortness of breath. Patients with known end-stage renal disease (dialysis and/or MDRD < 30 ml/min). Patients with known cognitive impairment. Communication issues with patient/language barrier. Patients already participating in an interventional cardiology or cardiovascular trial.