Inclusion Criteria:  Adult aged ≥ 18 years old ALS defined, probable or likely based on neurophysiological data according to Airlie House criteria (Brooks, 2000) Sporadic ALS or familial ALS defined by the existence of a case of ALS or FTD among first or second degree relatives of the patient included (Byrne et al, 2011). Participant affiliated to a social security scheme Free, informed and signed consent for the examination of the genetic characteristics of the participant  Exclusion Criteria:  All conditions mimicking ALS including motor neuropathies with multiple conduction blocks and all cases of ALS that do not meet the criteria of the Airlie House classification. Patients who are cognitively incapable of signing the consent to participate in this study.