Inclusion Criteria:  Diagnosis of first acute STEMI in accordance with the European Society of Cardiology (ESC) Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation Symptoms consistent with STEMI with beginning greater than 30 minutes but less than 12 hours prior to primary percutaneous coronary intervention (PCI) CRP elevation of ≥7 mg/l measured between 6 to 16 hours after primary PCI Eligible for primary PCI Age ≥18 years Written informed consent  Exclusion Criteria:  Prior acute myocardial infarction, coronary artery bypass surgery or PCI. Persistent hemodynamic instability (Killip class >2 including cardiogenic shock) or resuscitated cardiac arrest not allowing a CMR scan. The patient is febrile (temperature >38°C) or has experienced an acute infection with fever in the last 14 days. CRP >15 mg/l at time of hospital admission. Chronic inflammatory disease. Known history of severe hepatic failure Chronic kidney disease with a creatinine clearance <30ml/min./1.73m² Contraindication to CMR. Pre-STEMI life expectancy of <1 year Participation in another interventional trial Limited possibility to join the follow-up examinations (e.g. patient lives abroad) Pregnancy