Inclusion Criteria:  Age between 40 and 81; Body mass index (BMI) between 21.5 and 29.3; Chronic history (for at least 4 months) of knee joint pain; Radiographically documented knee osteoarthritis of grades 1 to 3 (Kellgren-Lawrence (K-L) radiographic classification scale)  Exclusion Criteria:  Radiographically severe documented knee osteoarthritis of grade 4 (K-L radiographic classification scale); Previous femur and tibia fractures; Knee previous surgical treatment (e.g., arthroscopy); Hyaluronic acid infiltration within the previous six months; Hemoglobin levels <10 g/dL; History of oncohematological disease, infections, or immunodepression