Inclusion Criteria:  Patients must be female, and at least 19 years old. Patients must be ASA grade I or II. Patients must be undergoing total mastectomy with IBR using tissue expander or implant, with or without axillary surgery.  Exclusion Criteria:  Patients have a known contraindication for a regional block: known coagulation disorder, treatment with anticoagulants, infection at the injection site, known allergy to medication in the study. Patients who are pregnant at the time of surgery. Patients having bilateral mastectomy and immediate alloplastic breast reconstruction (as only one side can be blocked to prevent local anesthesia toxicity). Patients with ASA Class III or IV. Patients with BMI>35kg/m2. Patients weighing less than 50kg. Patients living/staying outside of 1-hour driving distance from hospital.