Inclusion Criteria:  Patients aged between 20 years and 75 years Patients have H. pylori infection and have not treated with oral antibiotics Patients are willing to receive the intraluminal therapy. The written informed consents will be obtained from all patients prior to enrollment.  Exclusion Criteria:  Patients will be excluded from the study if any one of the following criteria is present:  Children and teenagers aged less than 20 years, or adult greater than 75 years Contraindication for endoscopic examination or food retention in the gastric lumen History of gastrectomy; Gastroduodenal stenosis、deformity or obstruction; Gastroduodenal malignancy, including adenocarcinoma and lymphoma Contraindication to treatment drugs: previous allergic reaction to antibiotics of study, PPI (Lansoprazole), Acetylcysteine and Sucralfate; pregnant or lactating women Severe concurrent acute or chronic illness: renal failure, decompensated cirrhosis of liver, incurable malignant disease Patients who cannot give informed consent by himself or herself