Inclusion Criteria:  Clinical diagnosis of OI type III or IV. Malocclusion of intermediate severity defined as a PAR score between 15 and 40. Age range 12 to 40 years at the screening visit. Presence of minimum number of intact teeth to proceed with orthodontic treatment.  Exclusion Criteria:  Prior orthodontic treatment defined as - any history of braces, palatal expansion or Invisalign treatment. Candidates who meet the PAR score but need surgical intervention for correction of malocclusion Presence of impacted or retained teeth. Use of medication, other than bisphosphonates, known to affect bone metabolism and contraindicated on orthodontic treatment, examples are, growth hormone, corticosteroids (chronic use) and thyroid hormones. Presence of other dental, oral or systemic conditions that may interfere with orthodontic treatment. Examples are severe gingivitis, active periodontal disease, cancer. Pregnancy - positive during screening visit.