Inclusion Criteria:  Vaccination with two doses of Coronavac vaccine or BNT162b2 vaccine Eastern Cooperative Oncology group performance status < 3  Exclusion Criteria:  Previous SARS-CoV-2 infection Vaccination with booster vaccine more than 12 weeks before informed consent Intravenous inmunoglobulin therapy 60 days before informed consent Any condition that could interfere with the paticipant´s participation during the study in the opinion of the treating investigator.