Inclusion Criteria:  PA diagnosis Voluntary to sign on the informed consent and willing to complete all follow-up; Have legal capacity and willingness to surgery AVS succeeded  Exclusion Criteria:  AVS failure or indeterminate subtype Pregnant or lactate Malignant tumor Refuse to AVS Complicated with Cushing syndrome Glucocorticoid remediable aldosteronism (GRA) or Liddle syndrome Rejected or intolerant to surgery, such as NYHA class 3 or 4, Severe anemia (Hb<60g/L)、stroke or acute coronary syndrome occurred within 3 months、end stage cirrhosis、eGFR<30ml/min/m2、untreated aneurysms, etc.