Inclusion Criteria:  Clinical characteristics that meet the criteria of the current International Headache Classification for Migraine or Chronic Migraine. Age >18, <65 years of both sexes At least 8 days of migraine/month and Migraine Disability Assessment Questionnaire (MIDAS) score greater than 11 at baseline*.  Lack of benefit or intolerance or contraindication to at least three classes of drugs for the preventive therapy of migraine*.  Drug Italian Agency (AIFA) criteria for the prescription of monoclonal antibodies directed against CGRP.  Exclusion Criteria:  dementia, psychosis, mental retardation women of childbearing age without contraceptive protection, pregnant and lactating women