Inclusion Criteria:  moderately to severely active ulcerative colitis, defined as a total score of 6 to 12 on the Mayo scale (scores range from 0 to 12, with higher scores indicating more severe disease) and a subscore of at least 2 on the endoscopic component of the Mayo scale (subscores on each of the four components of the Mayo scale range from 0 to 3) Patients who had colonic involvement of at least 15 cm Patients who had a confirmed diagnosis of ulcerative colitis at least 3 months before screening and confirmed by Pathology  Exclusion Criteria:  Patients who had previously used any TNF inhibitor Patients who were steroid-dependent or steriod-resistant Patients who had undergone subtotal colectomy or total colectomy Patients who had stoma