Inclusion Criteria:  Patients with age group 20-60 years, because it is the most common age group affected by CKD and they appropriate to apply for the study program. Both male and female patients who are undergoing hemodialysis and suffer from muscle cramps. Patients who are receiving two or more HD sessions a week, to facilitate patients follow-up. Patients who are willing to participate, because the patients' participation is voluntary. Patients who are alert and able to communicate verbally, to make the program applicable and facilitate the data collection.  Exclusion Criteria:  Emergency hemodialysis patients, to avoid mal-efficient (harmlessly apply the program). Patients with vascular access in a lower extremity, to avoid vascular access failure. Patients with skin sores, wounds, dermatitis, or edema of the lower extremities, with a known history of deep vein thrombosis (DVT), peripheral vascular disease (PVD), or peripheral neuropathy, to prevent complications. Patients who are unable to communicate, because the patients' communication is an essential part of data collection. Patients who suffer from breathing difficulty, because the application of the program required patients compliance and may cause fatigue among involved patients Not willing to participate, because the patients' participation is voluntary.