Inclusion Criteria:  Female patients aged 18-70 years. Metastatic breast cancer included unresectable locally advanced breast cancer, de novo stage IV breast cancer, and recurrent metastatic breast cancer. HR+ was defined as estrogen receptor- or progesterone receptor-positive status by immunohistochemistry. HER2 status was determined by immunohistochemistry or fluorescence in situ hybridization. Palbociclib treatment of metastatic breast cancer for at least one cycle. Available medical history.  Exclusion Criteria:  1.Incomplete medical history.