Inclusion Criteria:  The subject (male and female) aged between 20 ~ 65. The subject planned a first thyroidectomy for thyroid disease. The subject did not have medical history of esophagus-related disease The subject was suitable for local anesthesia or general anesthesia (Respiration and Intravenous anesthesia) The subject who could communicate with the investigators fluently, understands the purpose of clinical trial and the risk of participation in the clinical trial, and was willing to comply with guideline for clinical trial. The subject has been informed of the nature of the study (objective, methodology, efficacy, etc.) and signed written informed consent. The subject has been informed the efficacy and risk of anesthesia related to the surgery, procedures and examination, etc. and singed written informed consent. The subject who agrees to comply with permitted contraception during the study (example of permitted contraception: using condom and infertility surgery, etc.)  Exclusion Criteria:  The subject had general or local infection. The subject was diagnosed with liver and/or kidney and coagulation abnormalities. The subject took the prohibited concomitant medication. The subject had suppressed immunity or autoimmune disease The subject had hypersensitivity to the investigational devices. The subject was pregnant of a nursing mother or those who plan pregnancy during the study. The subject had serious disease that may affect to the study justified by Investigators (example: heart failure, kidney failure, pancreatitis, and diabetes, etc.) The subjects participate in another investigational study after enrollment of this study or subject previously participated in another investigational study within last 3 months before participating in this study. The subject considered to be not eligible to participate in the study justified by Investigator