Inclusion Criteria:  Patients are candidates for elective primary total knee arthroplasty for a diagnosis of osteoarthritis or inflammatory arthritis. Patients ≥18 years of age Patients have been medically cleared and scheduled for surgery Patients' primary care physician has verified that the patient can safely take the described dose of Losartan for the duration of the study period.  Exclusion Criteria:  Any contraindications to Losartan Revision surgery Surgery for fracture, infection, or malignancy Patients with a diagnosis of post-traumatic arthritis Bilateral, simultaneous surgery Patients already taking an ACE-inhibitor or Angiotensin receptor blocker for hypertension