Inclusion Criteria:  Inclusion Criteria for study Arms 1, 2 and 3:  Participant is willing and able to give informed consent for participation in the study. Male or Female, aged 18 -99 years.  Inclusion Criteria for study Arm 4:  • Male or Female, aged 18 -99 years.  Exclusion Criteria:  Exclusion Criteria for Study Arms 1, 2 and 3:  Unable or unwilling to consent Active cancer  Exclusion Criteria for Study Arm 4:  Participation in Study Arms 1, 2 or 3 Existing opt-out from use of data for research purposes