Inclusion Criteria:  Overall:  anomaly on MRI of the lissencephaly spectrum (lissencephaly, pachygyria, subcortical band heterotopia  Diagnostic track:  No established genetic diagnosis by conventional WES/WGS  Research track:  An established genetic diagnosis by conventinal WES/WGS  Exclusion Criteria:  No anomaly of the lissencephaly spectrum on MRI