Inclusion Criteria:  Both male and female; Age from 18 to 65 years; Documented history of CU for at least 6 weeks prior to entry in the study; Meet EAACI/GA2LEN/EDF/WAO 2017 guidelines, i.e. spontaneous appearance of wheals, angioedema or both for > 6 weeks due to known or unknown causes; Symptom severity must be greater than 10 points (UAS7 score); Able to complete questionnaires and take medications as scheduled; and Agree to participate in the study and sign the informed consent.  Exclusion Criteria:  Dual deficiency of Qi and blood according to Chinese medicine theory Urticaria is induced by physical factors (e.g., cold urticaria, delayed pressure urticaria, solar urticaria, heat urticaria, vibratory angioedema) only; Known to have dermatological diseases with skin pruritus; Known to have any serious diseases such as cancer, severe kidney and liver impairments, autoimmune disease, thyroid disease, Hodgkin's disease, lymphoma, severe mental disorders, leukemia, and acute infectious disease; Known to use oral/injectable corticosteroids, leukotriene inhibitors, immunosuppressants or other Chinese herbal medicine within one month of enrollment; Known to receive omalizumab, ligelizumab, or other experimental biologic for CU; Documented pregnancy or planning to conceive, breast-feeding women; or Operate heavy machinery or need to drive motor vehicles as an essential part of their profession. Know recent history (within previous 12 months) of drug addiction or alcohol abuse. Involved in other interventional clinical studies at the same time.