Inclusion Criteria:  Patients diagnosed with hypertrophic cardiomyopathy by medical history, physical examination and echocardiography.  Exclusion Criteria:  Patients with cardiac hypertrophy caused by other factors such as hypertension, diabetes, myocardial amyloidosis, mitochondria cardiomyopathy, congenital heart disease, valvular heart disease, etc; Patients who had underwent heart transplatation; Individuals not suitable for the present study due to maligant tumor or severe trauma will be excluded.