Inclusion Criteria:  -The participant must meet ALL of the following criteria to be considered eligible for the study:  Male or Female, aged 18 years or above. Requiring gastroscopy and/or colonoscopy to investigate gastrointestinal symptoms, or as part of screening or ongoing surveillance of GI neoplasia. Participant is willing and able to give informed consent for participation in the study.  Exclusion Criteria  The participant may not enter the study if ANY of the following apply:  Patients with endoscopically active severe oesophagitis Poor bowel preparation