Inclusion Criteria:  Severe motor impairment Able to give consent Appropriate candidate for neurointerventional procedure Able and willing to access all clinical testing and not impeded by geographical location Proficient in English Have a study partner  Exclusion Criteria:  Active condition resulting in immunosuppression Unsuitable for general anaesthetic Anaphylactic allergy to contrast media Allergy to nickel History of pulmonary embolism History of recent deep vein thrombosis Psychiatric or psychological disorder Unable to provide evidence of COVID vaccination