Inclusion Criteria:  FPG 5.6mmol/L~6.9mmol/L or OGTT 2H blood glucose 7.8mmol/L~11.0mmol/L or HbA1c 5.7%~6.4%, the above 3 indicators need to meet at least 2 items； Age 18 ~ 70 years old (including boundary value); Patients who voluntarily signed the informed consent and had conditional follow-up.  Exclusion Criteria:  Regularly take drugs affecting blood glucose within 1 month before screening, such as hypoglycemic drugs, glucocorticoids, niacin β- Adrenergic agonists, thyroid hormones, contraceptives, diazoxide, diuretics, phenytoin sodium γ- Interferon, etc; Combined with various diseases that may significantly shorten life expectancy, such as malignant tumors, severe organ failure and so on; Combined with various diseases that may seriously affect the subject's participation in the test, such as psychosis, serious motor system abnormalities, etc; Combined ALT or ast > 2.5 times the upper limit of normal value, or serum creatinine > 1.5mg/dl; Allergic to the test drug or its components; Pregnant or lactating women, or women who have pregnancy plans from the study period to 3 months after the last administration, or men who are unwilling to take a medically recognized effective non drug contraceptive measure. Chronic diarrhea caused by inflammatory bowel disease and irritable bowel syndrome; The investigator believes that it is inappropriate to be included in this trial.