Inclusion Criteria:  Any tumor presenting a variant of the exonuclease domain of POLE (exons 9 to 14) classified as pathogenic by the project working group, including: the 4 hotspots of mutations described (codons 286 (P286R/H/L), 411 (V411L), 459 (S459F), 424 (L424/V/I), (2). Any tumor presenting a variant of the exonuclease domain of PolD1 (exons 8-12), classified as pathogenic by the project working group, including : C319Y(10).  Diagnosis made from the date of launch of the cohort and in the previous year  -Age ≥ 18 years  Exclusion Criteria:  Tumor without POLE or POLD1 mutation Tumor with POLE mutation identified in research studies retrospective research Opposition of the patient to the registration of his data in the cohort