Inclusion Criteria:  Male or female patients 18 years and above. Patients who give written informed consent Patients with performance status - 0,1 or 2 (ECOG scale)  Patients receiving any of the following high dose chemotherapy regimens for autologous transplant in any indicated malignant disease.  Melphalan- 200 mg/m2 or more (MEL-200 mg/m2) Busulfan and Melphalan (BuMEL) Carmustine (BCNU), Etoposide, Cytosine Arabinoside and Melphalan ( BEAM) Patients who have creatinine clearance > 50 ml/min Patients with serum bilirubin levels < 2mg/dl. and serum liver enzymes (ALT or AST or both) lesser than 5 times the upper limit of normal value.  Exclusion Criteria:  Patients who are on NSAIDs, aspirin, antioxidants or systemic steroids for more than 3 months and the last dose taken within the last one week. Patients being treated for active infection at the time of starting high dose chemotherapy.