Inclusion Criteria:  Any sex. That they agree to participate in the study and give their informed consent in writing. Age between 18 and 65 years old at the beginning of the study. Patients with essential arterial hypertension with BP ≥140 / 90 mmHg and <180/110 mmHg. Women of childbearing potential using a contraceptive method (barrier, oral hormonal, injectable, subdermal), menopausal or surgically sterile.  Exclusion Criteria:  The drug is contraindicated for medical reasons. Glomerular filtration rate ≤30 ml / min x 1.73 m2. Hypersensitivity to any of the components of the formula or other sulfonamides. Patients treated with other diuretics. Patient with a history of vascular disease (cerebrovascular disease, acute coronary syndrome, etc.) and acute renal failure in the last 6 months. Patient with severe complications of type 2 diabetes mellitus (Ketoacidosis or hyperosmolar nonketotic coma). Patients participating in another clinical study involving an investigational treatment or participated in one in the previous 4 weeks. Positive pregnancy test, women who are pregnant, breastfeeding or planning a pregnancy while conducting the study. Oncological patients (except basal cell skin cancer) or with serious diseases that, in the opinion of the investigator, have a serious prognosis or a life expectancy of less than 1 year, as well as mental illnesses. Patients diagnosed with gout. Patients whose participation in the study may be influenced (employment relationship with the research center or sponsor, inmates, etc.).