Inclusion Criteria:  Diagnosis of degenerative lumbar diseases with symptoms of low-back pain and/or leg pain for at least 3 months, which was not be adequately controlled by nonoperative treatments. Diagnosis of osteoporosis, defined as a bone mineral density (BMD) at lumbar or femoral neck with 2.5 standard deviations or more below the mean peak bone mass (T scores <-2.5 SD) measured by dual-energy X-ray absorptiometry (DXA). Patients will be underwent single-level or two-level lumbar interbody fusion.  Exclusion Criteria:  Paget disease of bone, Low laboratory tests for calcium, Previous radiation treatment or fusion surgery to lumbar spine, Bone tumors, Bone infection, Acute vertebral fractures Severe spinal deformities such as degenerative scoliosis, Other metabolic bone disease, History of a anti-osteoporosis medication Combined with severe morbidities, Uncorrected bleeding diatheses Application of steroids.