Inclusion Criteria of cases:  male and female aged 25 years or more written informed consent must be obtained before the enrolment diagnosis of defined MS  Exclusion Criteria of cases:  under the age of 25 unable to provide informed consent or to fill in the questionnaire  Inclusion Criteria of controls:  male and female aged 25 years or more written informed consent must be obtained before the enrolment  Exclusion Criteria of controls:  under the age of 25 unable to provide informed consent or to fill in the questionnaire history of MS