Inclusion Criteria:  patients with COVID-19 infection confirmed by polymerase chain reaction of nasopharyngeal and oropharyngeal swabs to the causative agent of this infection age from 18 to 75 years old from December 2020 to April 2021  Exclusion Criteria:  the patient's decision to withdraw from the study refusing to take the probiotic for a reason not related to the development of side effects.  Non-inclusion criteria:  age over 75 years old or under 18 years old, taking probiotics for 3 months prior to admission history of intolerance to probiotics or their components refusal to participate and sign informed consent pregnancy or breastfeeding presence of cancer or psychoemotional disorders renal failure at the time of admission (glomerular filtration rate less than 50 ml / min) hepatic failure at the time of admission (equivalent to cirrhosis class B or C on the Child-Pugh scale)