Inclusion Criteria:  Hospitalized patients at SBCH with confirmed COVID19 pneumonia (PCR + clinical signs/symptoms of lower respiratory disease) Patients currently on a ventilator Patients who meet the Berlin definition of ARDS Patients who have access to measure a mixed venous oxygen saturation (i.e., patients with an internal jugular central venous catheter) Patient and/or Legally Authorized Representative is willing/able to provide informed consent  Exclusion Criteria:  As tadalafil is currently a FDA Class B1 medication, indicating that little information is available, pregnant women along with women who are actively breastfeeding will be excluded from this series. All patients under 18 Patients who are routinely taking nitrate medications All patients using Tadalafil daily for pulmonary arterial hypertension (Note: patients using Tadalafil intermittently for erectile dysfunction may still participate in the study)