Inclusion Criteria:  All volunteers must satisfy the following criteria to be considered for study participation:  Understands study procedures and voluntarily provides written informed consent prior to the start of any study-specific procedures. Is a healthy adult male or a healthy adult female, 19 to 50 years of age (inclusive) at the time of screening. Has a body mass index (BMI) ≥18.5 and ≤32.0 (kg/m2) and a body weight of no less than 50.0 kg at the time of screening and check-in. Is medically healthy with no clinically significant screening results, as determined by the Principal Investigator (e.g., laboratory profiles are normal up to and including Grade 1 per DMID toxicity tables; Appendix 3), medical history, vital signs, ECG, or physical/neurological examination findings. Note: If exclusionary lab criteria are met, values may be confirmed by repeat evaluation. Has not used tobacco- or nicotine-containing products (including smoking cessation products), for a minimum of 6 months before dosing.  Females of non-childbearing potential, based on having undergone one of the following sterilization procedures at least 6 months before dosing:  Hysteroscopic sterilization. Bilateral tubal ligation or bilateral salpingectomy; Hysterectomy; or Bilateral oophorectomy. Or is postmenopausal with amenorrhea for at least 1 year before the first dose with serum FSH levels consistent with postmenopausal status (i.e., greater than 40 mIU/mL) at screening. Or, if female of childbearing potential, must agree to use an allowable form of birth control from screening until 14 days after study completion. The following are allowed birth control methods for this study: Vasectomized partner (at least 6 months before dosing); Non-surgical permanent sterilization (e.g., Essure® procedure) at least 3 months before dosing. Double barrier method (e.g., diaphragm with spermicide; condoms with spermicide). Intrauterine device (IUD). Abstinence (and must agree to use a double barrier method if they become sexually active during the study); Implanted or intrauterine hormonal contraceptives in use for at least 6 consecutive months before study dosing; and/or Oral, patch, or injected contraceptives, or vaginal hormonal device (i.e. NuvaRing®), in use for at least 3 consecutive months before study dosing.  If a non-vasectomized male (or male vasectomized less than 120 days prior to study start) must agree to the following during study participation and for 90 days after the last administration of study drug:  Use a condom with spermicide while engaging in sexual activity or be sexually abstinent Not donate sperm during this time. In the event the sexual partner is surgically sterile or postmenopausal, use of a condom with spermicide is not necessary. None of the birth control restrictions listed above are required for vasectomized males whose procedure was performed more than 120 days before study start. Is willing to answer inclusion and exclusion criteria questionnaire at check-in. Is able to comply with the protocol and the assessments therein, including all restrictions. Is willing and able to remain in the study unit for the entire duration of the assigned confinement period(s), return for outpatient visit(s), and receive a phone call for follow-up questioning about AEs.  Exclusion Criteria:  Volunteers will be excluded from study participation for any of the following:  History or presence of clinically significant cardiovascular, pulmonary, hepatic, renal, hematological, gastrointestinal, endocrine, immunologic, dermatologic, neurological (including epilepsy), oncologic, or psychiatric disease or any other condition that, in the opinion of the Investigator, would jeopardize the safety of the subject or the validity of the study results. Any abnormality on neurologic exam. History of any illness that, in the opinion of the Investigator, might confound the results of the study or pose an additional risk to the subject by their participation in the study. Surgery within the past 90 days prior to dosing as determined by the Investigator to be clinically relevant, or any history of cholecystectomy. History or presence of alcoholism or drug abuse within the past 2 years as determined by the Investigator to be clinically relevant. History of sensitivity or contraindication to use of linezolid, tedizolid, or any study investigational products. Participation in another clinical trial within 30 days prior to dosing. Female subjects who are pregnant or lactating. Positive result on a urine drug/alcohol/cotinine screen at Baseline or check-in. Seated blood pressure is less than 90/40 mmHg or greater than 140/90 mmHg at screening. Out-of-range vital signs may be repeated once for confirmation. Seated heart rate is lower than 40 bpm or higher than 99 bpm at screening. Out-of-range vital signs may be repeated once for confirmation.  Any clinically significant ECG abnormality at Screening (as deemed by decision of the Investigator and the Sponsor's Medical Monitor). NOTE: The following may be considered not clinically significant without consulting the Sponsor's Medical Monitor:  Mild first-degree A-V block (P-R interval <0.23 sec) Right or left axis deviation Incomplete right bundle branch block Isolated left anterior fascicular block (left anterior hemiblock) in younger athletic subjects Early repolarization Tall T waves RSR in V1/V2 consistent with right ventricular conduction delay (with acceptable QRS) Sinus rhythm or sinus bradycardia with sinus arrhythmia Minimal or moderate voltage criteria for left ventricular hypertrophy (LVH). QTcF interval >450 msec for males or >470 msec for females at screening, Day -1, or Day 1 (predose), or history of prolonged QT syndrome. For the triplicate ECGs taken at screening and on Day -1, the average QTcF interval of the three ECG recordings will be used to determine qualification. Family history of long-QT syndrome or sudden death without a preceding diagnosis of a condition that could be causative of sudden death (such as known coronary artery disease, congestive heart failure, or terminal cancer).  History of any of the following:  Serotonin syndrome Seizures or seizure disorders, other than childhood febrile seizures Brain surgery History of head injury in the last 5 years Any serious disorder of the nervous system particularly one that may lower the seizure threshold. Lactose intolerant. Specific Treatments Use of any prescription medication within 14 days prior to dosing. Use of any of the following medications within 30 days before the first dose of study drug or during the study drug treatment period: monoamine oxidase (MAO) inhibitors (phenelzine, tranylcypromine), tricyclic antidepressants (amitriptyline, nortriptyline, protriptyline, doxepin, amoxapine, etc.), antipsychotics such as chlorpromazine and buspirone, serotonin re-uptake inhibitors (fluoxetine, paroxetine, sertraline, etc.), bupropion, agents known to prolong the QTc interval (erythromycin, clarithromycin, astemizole, type Ia [quinidine, procainamide, disopyramide] and III [amiodarone, sotalol] anti-arrhythmics, carbamazepine, sulfonylureas, and meperidine). Use of any over-the-counter (OTC) medication, including herbal products and vitamins, within 7 days prior to dosing, except acetaminophen. Up to 3 grams per day of acetaminophen is allowed at the discretion of the Investigator prior to dosing. Use of any drugs or substances known to be significant inhibitors of cytochrome P450 (CYP) enzymes and/or significant inhibitors or substrates of P-glycoprotein (P-gp) and/or organic anion transporting polypeptides (OATP) within 14 days prior to the first dose of study drug. Use of any drugs or substances known to be inducers of CYP enzymes and/or Pgp, including St. John's Wort, within 30 days prior to the first dose of study drug. Use of any drugs or substance known to lower the seizure threshold. Specific Laboratory Abnormalities Serum magnesium, potassium, or calcium laboratory values outside of the normal range at screening. If exclusionary lab criteria are met, values may be confirmed by repeat evaluation. Positive results at screening for human immunodeficiency virus (HIV), hepatitis B surface antigen (HBsAg), or hepatitis C antibodies (HCV). ALT or AST greater than ULN.