Inclusion Criteria:  Diagnosis of Mesoamerican nephropathy Stages 3 and 4 No other renal disease No essential hypertension  Exclusion Criteria:  Significant abnormalities in laboratory tests that contraindicate surgical procedures. Acute pathology or complications of significant chronic pathologies in the 6 months prior to study entry, including, but not limited to:  Medical history of deep vein thrombosis Uncontrolled hypertension Active infection Reduced cardiac ejection fraction Hepatitis B, C or HIV Diabetes treated with insulin or glucose lowering agents Anemia (Hb <9 g/dL) History of cancer Severe depression (Beck scale) Autoimmune disease