Inclusion Criteria:  Males and post menopausal females Aged between 40 - 60 years BMI of 18.5 - 34.9 kg/m2 Over the last 6 months has participated in less than 150 mins of moderate intensity physical activity or 75 mins of vigorous activity or a combination of both, but takes part in some form of physical activity within their weekly routine. Maximal oxygen uptake categorised as 'fair' for a given age group.  Exclusion Criteria:  Previous myocardial infarction or cerebrovascular event Any signs or symptoms of cardiovascular issues High blood pressure: SBP >180 mmHg and / or DBP >100 mmHg Orthostatic hypotension: Drop of SBP > 20mmHg and / or DBP >10 mmHg upon standing. Changed blood pressure medication in the 6-month period prior to the study Plan to change any form of relevant medication during study period Suffers from diabetes Suffers from severe asthma Currently have any infections or symptoms of an infection (e.g. COVID-19 etc) Suffers from a neurodegenerative disease Cannot understand and/or fully cooperate with the study protocol Exercise-limiting comorbidity (e.g. angina, chronic lung disease, arthritis etc) Severe peripheral neuropathy (cannot sense temperature) Current smoker or have stopped in the last 3 months Any skin conditions including ulcerations Exposed to high temperatures in the last 4-weeks (e.g. holiday, spa, sun beds etc) Use of antioxidant supplements in the last 6-weeks