Inclusion Criteria:  Patients of both sexes suffering from OA in hospital for the surgical treatment of OA (endo- or arthroplasty, or arthroscopy) with an interval of at least three months from any previous infiltrative treatment of any kind; Patients with a Kellgren and Lawrence (KL) [Kohn 2016] score greater than or equal to grade III will be enrolled in the 'Moderate-severe OA' group and those with grade I and II KL scores in the 'MIld OA' group; Patients able to provide the list of medications and supplements taken; Patients able to provide informed consent to treatment.  Exclusion Criteria:  Patients who have undergone previous joint surgery or who have excessive joint deformity. Patients with recent trauma, osteonecrosis or OA induced by previous or current joint infection; Patients with metabolic pathologies; Patients with previous or current oncological pathologies; Women in a climacteric (date of last menstruation less than one year); Patients with severe cognitive deficits or psychiatric disorders; Autoimmune diseases (eg rheumatoid arthritis).