Inclusion Criteria:  patients with end-stage kidney disease who are ready for kidney transplantation; Panel reactive antibodies (PRA) less than 20%. informed consent to participate in the study.  Exclusion Criteria:  recipients preparing for combined organ transplantation; recipients with previously performed transplantation of another organ; recipients preparing for transplantation with a different immunosuppressive regimen; upcoming blood group incompatibility (AB0-i) transplant; PRA antibodies more than 20%;