Inclusion Criteria:  They were 18-75 years old; From thoracic vertebrae to lumbar vertebrae, pedicle screw fixation is needed; Signed informed consent, willing to receive treatment and follow-up according to the requirements of the trial protocol.  Exclusion Criteria:  Patients with pedicle deformity. Patients with severe osteoporosis. Patients with spinal tumor or tuberculosis. Patients with abnormal liver function (alanine aminotransferase, aspartate aminotransferase values > 3 times of the upper limit of the normal range) and abnormal renal function (creatinine values > 3 times of the upper limit of the normal range). Patients with abnormal coagulation function (prothrombin time, activated partial thromboplastin time > 1.5 times of the upper limit of normal range). Pregnant or lactating women. Patients with mental disorders. The investigators evaluated patients who were not suitable for pedicle screw fixation. Patients who are participating in clinical trials of any other device or drug. Poor compliance, difficult to cooperate with patients who complete treatment and follow-up.