Inclusion Criteria:  Participants over 18 years old Consent to participate by signing the consent form. No intravenous antineoplastic therapy regimen schedule (clinical follow-up). To have a functioning, fully implantable catheter with venous return, no resistance during solution infusion, no obstruction or evidence of infection at the time of recruitment.  Exclusion Criteria:  - Use of any type of anticoagulant / antiplatelet drugs.