Inclusion Criteria:  Male or female patients of 18-75 years old; Clinical or histopathological diagnosis of hepatocellular carcinoma; ECOG PS score of 0-1, Child-Pugh grade A; Chinese stage IIb/IIIa (equal to BCLC B/C) patients with portal vein tumor thrombus (according to the Japanese PVTT grading criteria Vp3-Vp4) or more than 3 tumor nodules, without extrahepatic metastasis; According to the evaluation by the site multi-disciplinary team (MDT), surgical resection is not the current preferred treatment; No previous systemic treatment for hepatocellular carcinoma; no previous use of PD-1 inhibitor, PD-L1 inhibitor, lenvatinib or sorafenib; Previous TACE treatment for 0-2 times The patients in the treatment group voluntarily and have decided to receive treatment of lenvatinib in combination with toripalimab and TACE, and sign an informed consent form. Additional identification of qualified subjects: subjects who have received at least one combination medication enter the safety evaluation; subjects who have received at least one imaging evaluation after treatment enter the efficacy evaluation. The patients in the control group treated with TACE alone have at least one imaging evaluation. Patients with HBV infection (characterized by hepatitis B surface antigen [HBsAg] positive and/or hepatitis B core antibody [anti-HBcAb], with detectable HBV DNA [>10 IU/mL]) should be treated with antiviral therapy according to clinical routine, so as to ensure adequate viral suppression (HBV DNA≤2000 IU/mL or 104) before enrollment. Patients must maintain antiviral therapy during the study period and within 6 months after the last study drug administration; patients with positive hepatitis B core antibody (HBc) and undetectable HBV DNA (<10 IU/mL) will be not required to receive antiviral therapy before enrollment; these patients will be checked every cycle to monitor HBV DNA levels; if HBV DNA is detected (> 10 IU/mL), antiviral therapy will be initiated; patients with detectable HBV DNA must continue to receive antiviral therapy during the study  Exclusion Criteria:  Clinical or pathological diagnosis of mixed liver cancer, fibrolamellar hepatocellular carcinoma or other non-hepatocellular malignant tumor components; Hematological examination: PLT<50×109/L, WBC<3.0×109/L or not meet the requirements of TACE treatment; Coagulation function: international normalized (prothrombin time) ratio (INR) > 1.2; Liver function indicators: serum albumin (ALB) < 2.8 g/dl, serum total bilirubin (TBIL) > 1.5 times the upper limit of normal (excluding those with biliary obstruction), serum transaminase (ALT and AST) > 3 times the upper limit of normal; Renal function indicators: serum creatinine (CR) > 1.5 times the upper limit of normal; Uncontrollable hypertension (defined as diastolic blood pressure > 90 mmHg or systolic blood pressure > 150 mmHg); Patients with bile duct tumor thrombi, superior mesenteric vein tumor thrombi and diffuse portal vein tumor thrombi; Participated in other clinical trials 30 days before screening; Accompanied by hepatic encephalopathy, Gilbert syndrome, sclerosing cholangitis, etc.; Acute gastrointestinal bleeding recorded within the last 3 months; Have a history of allogeneic transplantation (such as liver transplantation); Patients with acute or chronic active hepatitis B or C infection, hepatitis B virus (HBV) DNA > 2000IU/ml or 104 copies/ml; hepatitis C virus (HCV) RNA > 103 copies/ml; those who are positive for both hepatitis B surface antigen (HbsAg) and anti-HCV antibodies. Patients who have autoimmune diseases or a history of autoimmune diseases or syndromes requiring systemic use of steroids / immunosuppressants, including hypophysitis, pneumonia, colitis, hepatitis, nephritis, hyperthyroidism, hypothyroidism etc. Be suspected of being allergic to study drugs; Patients with other organ dysfunction who are expected to be unable to tolerate general anesthesia or hepatectomy; Other conditions in which the investigators deem the patients unsuitable for the clinical trial