Inclusion Criteria:  Known biliary-tract cancer including intrahepatic-, extrahepatic- and gallbladder carcinomas age ≥18 years signed informed consent form planned for (or recently started - i.e. within the last 21 days)) neoadjuvant, adjuvant or 1st line therapy  Exclusion Criteria:  Patients who are unable to consent because they do not understand the nature, significance and implications of the registry and therefore cannot form a rational intention Patient under 18 years of age Patient's inability to complete QoL questionnaire or answer the questions. Second-line or further palliative therapies if the patient's first-line therapy was not documented within the study.