Inclusion Criteria:  Individuals aged 50 to 65 years. Individuals with at least one advanced adenoma (tubulovillous or villous histology, high grade dysplasia or ≥ 10mm), and / or at least three non-advanced adenomas detected and resected completely within the population-based CRC screening program.  Exclusion Criteria:  Personal history of CRC. Colonic lesion ≥10mm resected without histological diagnosis. More than 10 adenomas in baseline colonoscopy. Serrated polyposis syndrome. Two or more first-degree relatives with CRC. Hereditary predisposition to CRC. Relevant comorbidity with life expectancy inferior to 5 years. Colonoscopy with incomplete mucosal examination. Incomplete resection of baseline lesions. Non-acceptance after reading the informed consent.