Inclusion Criteria:  Renal cell carcinoma patient: histological confirmed clear cell tumor; First-line metastatic treatment; Stage IV with at least one measured lesion; Fresh-frozen primary tumor tissue available; No previous immunotherapy or tyrosine kinase inhibitor treatment; All International Metastatic RCC Database Consortium (IMDC) Risk Score; Karnofsky Performance Scale (KPS) >=70; >=18 years old.  Exclusion Criteria:  History of a known or suspected autoimmune disease; Any condition requiring systemic treatment with corticosteroids; Creatinine clearance < 40mL/min; Alanine aminotransferase (ALT) and/or Aspartate Aminotransferase (AST) > 5 x ULN; Pregnant women.