Select Inclusion Criteria:  Age ≥ 18 years  Prior diagnosis of Group 2 PH due to HFpEF, with the following resting hemodynamic criteria confirmed in the past year by right heart catheterization  mPAP ≥ 25 mmHg PVR ≥ 3 Wood units  Confirmation of the following hemodynamic criteria during supine exercise  mPAP/CO slope > 3 mmHg/L/min PCWP ≥ 25 mmHg, or PCWP/CO slope > 2 mmHg/L/min  Chronic symptomatic heart failure documented by the following:  NYHA HF Class II with history > II, or Class III, or ambulatory Class IV ≥ 1 HF hospitalization, or healthcare facility with IV diuretics or intensification of oral diuresis for HF within 12 months, or NT-pro BNP value > 400 pg/mL in normal sinus rhythm or > 750 pg/mL in atrial fibrillation in past 6 months Ongoing stable guideline directed medical therapy (GDMT) for HF and medically optimized per treating HF physician according to current ACCF/AHA guidelines that is expected to be maintained without change for 6 months (excluding diuretic dosage changes for HF optimization within 90 days of the Index Procedure) 6MWD ≥ 150 m  Select Exclusion Criteria:  Any therapeutic intracardiac intervention within the last 30 days PH Group 1, 3, 4 or 5 Mean RAP >12 mmHg by RHC at rest on room air  Right ventricular dysfunction, defined as one or more of the following  Greater than moderate RV dysfunction as assessed by TTE and/or MRI RV FAC < 35% TAPSE < 14 mm via TTE RV size severely enlarged compared to LV size as estimated by TTE and/or MRI Severe tricuspid valve regurgitation Peak systolic pulmonary arterial pressure > 80 mmHg by RHC at rest while awake Mean pulmonary arterial pressure > 50 mmHg by RHC at rest while awake PVR > 6 Wood units at rest while awake on room air Left ventricular ejection fraction < 50%  Severe heart failure, defined as one or more of the following:  ACC/AHA/ESC Stage D heart failure, non-ambulatory NYHA Class IV HF If BMI < 30, Cardiac Index < 2.0 L/min/m2 If BMI ≥ 30, Cardiac Index < 1.8 L/min/m2 Requires continuous intravenous inotropic infusion Requires mechanical circulatory support Currently on the cardiac transplant waiting list  Chronic renal dysfunction defined as one or more of the following:  Currently requiring dialysis; OR eGFR < 35 mL/min/1.73 m2 by the CKD-Epi equation  Chronic pulmonary disease defined as one or more of the following:  Requires continuous home oxygen therapy Recent hospitalization for exacerbation within 12 months prior to screening FEV1 < 50% predicted