Inclusion Criteria:  Adult (≥18 years old) patients presenting to the emergency department of Kiruddu National Referral Hospital (KNRH) with:  suspected infection [(any of): temperature >38 degrees Celsius or <36 degrees Celsius or (in the past seven days) fevers, rigors, night sweats or antibiotic use]; AND systolic blood pressure (SBP) <90 mmHg Evidence of a personally signed and dated informed consent document indicating that the subject (or a legal representative) has been informed of all pertinent aspects of the study. Subjects who are willing and able to comply with scheduled visits, treatment plan, laboratory tests and other study procedures.  Exclusion Criteria:  Pregnant or known active breast feeding Non-severe, localized, uncomplicated infection (e.g., cellulitis with only local symptoms) which is apparent on clinical examination Severe bleeding or hemorrhagic shock Hypotension likely secondary to a cause other than sepsis or sepsis-induced cardiac insufficiency Detainee or prisoner Admission to a surgical or obstetric/gynecological ward Emergency surgery required Previously recruited to the REVISTA-DOSE study History of end stage renal disease requiring dialysis Current symptomatic renal stones or or a previous diagnosis of primary hyperoxaluria or oxalate nephropathy History of allergic reactions to vitamin C or vitamin B1 Use of vitamin C at a dose greater than 1 g (oral or intravenous) within 24 hours of screening Chronic disease/illness that, in the opinion of the site investigator, has a lifespan of less than 30 days unrelated to current sepsis diagnosis (e.g., advanced malignancy or neurodegenerative disease). Previous or current enrolment in a trial in which co-enrolment is not allowed