Inclusion Criteria:  Age 18 years or older. Diagnosis of primary CAD. Hb level ≤ 9 g/dL. Documented results from bone marrow biopsy within 1 year of screening Either have vaccination against Streptococcus pneumoniae, Neisseria meningitidis (Types A, C, W, Y, and B), and Haemophilus influenzae (Type B) within 2 years prior to screening or agree to receive vaccination during screening. Women of childbearing potential (WOCBP), defined as any women who have experienced menarche and who are NOT permanently sterile or postmenopausal, must have a negative pregnancy test at screening and agree to use protocol-defined methods of contraception for the duration of the study and 8 weeks after their last IMP dose.  Men must agree to the following for the duration of the study and 8 weeks after their last IMP dose:  Avoid fathering a child. Use protocol-defined methods of contraception. Refrain from donating sperm. Willing and able to give written informed consent.  Exclusion Criteria:  Have received other anti-complement therapies (approved or investigational) within 5 half-lives of the agent prior to randomization. Treatment with rituximab monotherapy within 12 weeks prior to randomization, or rituximab combination therapies (e.g., with bendamustine, fludarabine, other cytotoxic drugs or ibrutinib) within 16 weeks prior to randomization. Diagnosis of systemic lupus erythematosus or other autoimmune diseases with antinuclear antibodies. History of an aggressive lymphoma or presence of a lymphoma requiring therapy. Have received an organ transplant. Cold agglutinin syndrome secondary to Mycoplasma pneumoniae, Epstein-Barr virus or other specific causative infection. Presence or suspicion of liver dysfunction as indicated by elevated alanine aminotransferase (ALT) > 2.5 x ULN, or direct bilirubin levels > 2 x ULN. Inability to cooperate with study procedures.