Inclusion Criteria:  Age from 18 to 85 years Patients with stroke within 30 days of enrollment attributed to 70% to 99% stenosis of a major intracranial artery (carotid artery, MCA stem [M1], vertebral artery, or basilar artery) on Computer Tomography angiography (CTA) (According to WASID method) The diameter of the target vessel is between 2.0mm-4.5mm Target area of stenosis is ≤14 mm in length Baseline mRS score ≤3 Patient understands the purpose and requirements of the study, can make him/herself understood, and has provided informed consent  Exclusion Criteria:  Patients with stroke within 7 days before enrollment. Tandem extracranial or intracranial stenosis (70%-99%) or occlusion that is proximal or distal to the target intracranial lesion (NOTE: anexception is allowed if the occlusion involves a single vertebral artery proximal to a symptomatic basilar artery stenosis and the contralateral vertebral artery is supplying the basilar artery) Patients with stroke caused by perforating artery occlusion CT angiographic evidence of severe calcification at target lesion Any history of brain parenchymal or other intracranial subarachnoid, subdural or extradural hemorrhage in the past 6 weeks Intracranial artery stenosis caused by non-atherosclerotic lesions, including: arterial dissection, moya-moya disease, vasculitis disease, herpes zoster, varicella-zoster or other viral vascular diseases, neurosyphilis, any other intracranial infections, any intracranial stenosis related to cerebrospinal fluid cells, radiation-induced vascular disease, fibromuscular dysplasia, sickle cell disease, neurofibromatosis, central nervous system benign vascular disease, postpartum vascular disease, suspected vasospasm, suspicious embolism recanalization, etc History of stenting or angioplasty of an intracranial artery; Presence of any unequivocal cardiac source of embolism; Combined with intracranial tumor, aneurysm or intracranial arteriovenous malformation Those who cannot tolerate general anesthesia due to insufficiency of cardiac or pulmonary function Patients who cannot receive dual antiplatelet therapy due to existing diseases or are tolerant to dual antiplatelet therapy confirmed by relevant test Patients with known severe hepatic and renal dysfunction Patients with known severe allergies or contraindications to heparin, paclitaxel, contrast agents and other related intravascular treatment drugs Patients with hemoglobin<100g/L, platelet count<100×1,000,000,000/L, INR>1.5 or there are uncorrectable factors leading to bleeding (if there are multiple checks, the last one shall prevail) Major surgery (including open femoral artery, aortic or carotid artery surgery) within the past 30 days or planned within 90 days Patients with renal artery, iliac artery, and coronary artery requiring simultaneous intervention Life expectancy <1 year Pregnant or lactating women Patients who cannot complete the follow-up due to cognitive, emotional or mental illness According to the judgement of the investigator, other situations that are not suitable for enrollment Enrollment in another study that would conflict with the current study