Inclusion Criteria:  Children of either gender, aged 6 months to 10 years will be recruited. Uncomplicated P. falciparum malaria confirmed by microscopy using Giemsa-stained thick film with an asexual parasite density within the range 1000 to 200000 parasites/μl. Presenting with fever (axillary temperature ≥ 37.5oC) or having a history of fever in the preceding 24 hours. Able to ingest tablets orally (either suspended in water or uncrushed with food). Willing to participate in the study with written informed consent from parent/guardian. Willing and able to attend the clinic on stipulated regular follow-up visits.  Exclusion Criteria:  Mixed or mono-infection with another Plasmodium species detected by microscopy. Children who are currently suffering or had the following within the last 2 months: tuberculosis, HIV, schistosomiasis, diabetes mellitus, cardiovascular disease, gout, rheumatoid arthritis, underlying chronic hepatic or renal disease, hypoglycaemia, jaundice, respiratory distress, and other inflammatory-related diseases.  Signs/symptoms indicating severe/complicated malaria" according to WHO criteria (WHO definition) such as:  Not able to drink or breastfeed. Persistent vomiting (>2 episodes within the previous 24 hours). Convulsions (>1 episode within the previous 24 hours). Lethargic/unconscious. Severe anemia (hemoglobin < 5 g/dl). Serious gastrointestinal disease. Presence of severe malnutrition defined as a child aged between 6-60 months whose weight-for-height is below -3 z-score (W/H < 70%) or has symmetrical oedema involving at least the feet or has a mid-upper arm circumference < 115 mm). Regular medication, which may interfere with anti-malarial pharmacokinetics. History of hypersensitivity reactions or contraindications to any of the medicine (s) being tested or used as alternative treatment (s). Individuals who have taken part in anti-malarial efficacy and safety studies in the last 3 months. Participants who have taken anti-malarial drugs within the last one month.