Inclusion Criteria:  Aged between 20 and 60 (male or female) Diagnosed chronic decompensated hepatitis B cirrhosis with a course of more than 5 years Not suitable for liver transplantation or there is no donor liver source No serious bleeding tendency or active bleeding No hepatic encephalopathy After strict medical conservative treatment for more than 6 months, there was no relief of symptoms or significant improvement of quality of life score Subjects voluntarily participate in this study and sign informed consent  Exclusion Criteria:  Be less than 20 years old or more than 60 years old Cirrhosis caused by other causes such as alcoholic hepatitis, hepatitis C virus and autoimmune hepatitis Found liver malignant tumor or the family history of liver malignant tumor in the third generation of their direct relatives Patients with hypersplenism who need splenectomy History of tumors in other organs PT prolongation is greater than 3 seconds Use of human serum albumin within 3 weeks prior to clinical registration Clinically significant upper gastrointestinal bleeding events occurred within 4 weeks before clinical registration Spontaneous peritonitis Active infection (viral or bacterial) Pregnant or lactating women The researcher considers it inappropriate to participate in this study