Inclusion Criteria:  Patient, male or female, over 18 years of age, hospitalized in ICU for at least 48 hours. Consent to participate in the patient's study or authorization to carry out the research collected from the designated trustworthy person (failing this, a family member, or failing this, a close and stable relation with the person concerned) according to the modalities described in Title II of the book of the First Public Health Code. If no relative is present, the patient may be included on the advice of the investigator (article L. 1111-6). A consent form for continuation of the study and use of the data will then be signed by the patient if and when the patient is again conscious and lucid, or if the patient is unable to express consent, authorization to continue the research will be obtained from the designated trusted person. Patient covered by a social security system.  Exclusion Criteria:  Predictable and uninterrupted maintenance of deep sedation throughout the duration of the stay, due to the seriousness of the lesions, from the moment the patient is admitted to the intensive care unit. Lack of predictable remission of a severe coma present on admission to intensive care. Refusal to participate by the patient, or by the trusted person contacted by default. Patient with DNR (do not resuscitate) orders. Patient under legal protection. Patient already included in the protocol during another stay in resuscitation