Inclusion Criteria:  Signature of the form consent for participation in the study Ph-negative ALL diagnosis without previous treatment.  Exclusion Criteria:  ALL with mature B phenotype (sIg +) or with the cytogenetic alterations characteristic of ALL mature B (t (8,14), t (2, 8), t (8, 22)). Ph-positive ALL Acute leukemias of ambiguous lineage (undifferentiated or mixed phenotype). Patients with a history of coronary, valvular or hypertensive heart disease, that contraindicate the use of anthracyclines. Patients with chronic liver disease in the activity phase and / or Bilirubin> 2 mg / dl and / or transaminases 5 times the normal limit, not related to ALL. Patients with severe chronic respiratory failure. Renal failure and / or creatininemia> 2 mg / dl not related to ALL. Serious neurological disorders, not related to leukemic disease. General condition affected (grades 3 and 4), not attributable to ALL. Uncontrolled infection by HIV, HTLV-1, HBV, HCV. Patient not a candidate for treatment based on the criteria of the treating physician. Pregnant women will have to be evaluated by a multidisciplinary team and an ethics committee.