Inclusion Criteria:  Male or female. informed consent. Age >40years. FEVl/FVC<70%. diagnosed 3 month before enrollment (mild-moderate) Reversability test pre-post bronchodilators FEVl predicted<200ml/hr and less than 12%.  Exclusion Criteria:  Asthmatic patient. patient already use B blockers. Acute exacerbation. Pregnency -lactation. Advanced cardiac, renal or liver disease according to investigator opinion.