Inclusion Criteria:  histologically proved adenocarcinoma of the rectum Age between 18 and 70 yrs T3 and T4 N1,N2 respectable tumor The WHO performance score 0-2 have a free metastatic work up excluded by chest x-ray , abdominal ultrasonography or CT pelviabdomen  Exclusion Criteria:  patients with locally advanced inoperable disease locally recurrent rectal cancer had a history of malignant tumor within 5 years except the skin cancer pregnant or lactating women previous irradiation in pelvis there was contraindication for neoadjuvent radiotherapy or surgery known metastatic disease mental disorder