Inclusion Criteria:  (1) Patients with chronic kidney disease who have signed the subject's consent and the glomerular filtration rate (eGFR) is less than 59ml/min/1.73m2 (2) Both male and female patients aged 20-85 years old are acceptable (3) You must be able to come back at a specific time each month during the 6-month trial  Exclusion Criteria:  If you have any of the following conditions, you will not be able to participate in this research project:  Drug abuse. Heart failure (stage 3-4) Mental illness (psychotic disorder, epilepsy, depression, panic disorder) Patients who have undergone dialysis or are expected to have a kidney transplant in the last three months The blood pressure still exceeds 150/90mmHg after using more than three antihypertensive drugs Pregnancy or planning to become pregnant or breastfeeding Malignant disease Acute illness (hepatitis, jaundice, acute myocardial infarction) in the last 3 months The patient is engaged in another research study. 3 months before entering the study or having used NSAIDs, anti-rejection drugs or performing imaging agent examinations during the study You have participated in other research study in the previous month You have drug dependence and drinking habits