Inclusion Criteria:  Patients undergoing care interventions of a given type (e.g. wound dressings/mobilization/…) recognized as painful (pain VAS >3 despite the usual analgesic protocol) Repetition of the same type of intervention at least three times within a month of interval after inclusion Patient age ≥15 years Informed consent from patient or legal guardian Beneficiary of the French healthcare fund  Exclusion Criteria:  Cognitive or psychiatric disorders preventing the patient from communicating with caregivers or understanding their instructions Any other concomitant nervous system, cardiac, or pulmonary disease that might affect the autonomous nervous system: (myocardial infarction, myocardial disorder (e.g. dilated or hypertrophic cardiomyopathy), class 3 or 4 heart failure, cardia dysrhythmia, including atrial fibrillation, conduction disorder, mechanical ventilation) Non-sinusal rhythm, extrasystoles, altered ECG signals Mandatory drug therapy that might affect the autonomous nervous system and NRV such as beta-blockers, muscarinic receptor blockers, vasopressin agents Contraindication for use of the virtual reality headset and/or hypnosis. Neurological disorder incompatible with use of the virtual reality headset and/or hypnosis (balance disorders/seizures…) Contraindication for using surface electrodes preventing collection of the main endpoint data Any disorder or disability preventing execution of the virtual reality or hypnosis techniques (deafness/blindness) Judicial protection status