Inclusion Criteria:  Healthy male and female subjects aged 40-70 years. Caucasian Non-smokers or ex-smokers Body Mass Index (BMI): ≥18.5 and ≤32 kg/m2 Presence of a negative SARS-CoV-2 PCR test.  Exclusion Criteria:  Complaints that may indicate the presence of an infection, including Covid-19. Pathological alcohol consumption. Positive alcohol breath test at the preliminary examination. Alcohol consumption within the last 24 hours before the start of sampling. History of drug dependence. Positive urine drug test during the preliminary examination. Clinically significant acute or chronic disease. In particular, chronic inflammation, rheumatological and other autoimmune diseases, diabetes and other metabolic diseases. Indications in the medical history or during the medical examination that may jeopardize the safety of the study participant by participating in the study. History of relevant clinically significant cardiovascular disorders or clinically relevant hyper- or hypotension or clinically relevant brady- or tachycardia at screening as assessed by an investigator. Heart rate <45/min after 5 minutes in a quiet sitting position. Heart rate >100/min after 5 minutes in a quiet sitting position. Systolic blood pressure of > 170 mmHg or < 90 mmHg. Diastolic blood pressure of > 95 mmHg and/or < 60 mmHg. Regular use of prescription medication within 3 months prior to inclusion in the research project. Use of non-prescription medications within 3 days prior to inclusion in the research project. Presence of clinically significant food intolerance and/or food allergy as assessed by the investigator. Medically relevant previous operations. Condition following radio- or chemotherapy. History of oncological diseases. Blood and/or plasma donation within the last 30 days prior to sample collection. Pregnant or nursing female. Employees of study site.