Inclusion Criteria:  • 18 years of age or older  Able to provide informed consent Pathologically and/or clinically confirmed diagnosis of advanced cancer  At any point of treatment with standard chemotherapy*  o Scheduled to start, have discontinued or completed, or currently receiving  Greater than or equal to 5% unintentional weight loss over the previous 3-6 months, not explained by simple starvation  o Simple starvation is considered to be excluded when weight loss is not ameliorated by standard nutritional counseling and oral supplementation over a 2-week period).  Life expectancy of at least 4 months  Able to communicate well and comply with study requirements, including by phone and written logs  Patients on Dexamethasone will be allowed  Exclusion Criteria:  • Abnormal liver function defined as > twice upper limit of normal  Elevated QTc  o EKG performed within 1 year of enrollment will be accepted  Total parental nutrition (TPN) or enteral feeds (PEG/PEJ) for >70% of their primary source of daily calorie intake Taking Marinol within 2 week of enrollment onto study