Inclusion Criteria:  Men and women aged 18 or over Subjects with a diagnosis of mild to moderate eczema with a SCORAD between 1-50.  Exclusion Criteria:  Individuals who have a known allergy to isosorbide diesters. Individuals who have solely hand and/or foot eczema without evidence of eczema anywhere else on their body. Individuals who have been on topical calcineurin inhibitors or crisaborole to the predetermined areas within two weeks of initiation of participation or unwilling to undergo a washout period. Subjects with an ongoing secondary infection of the skin. Subjects who are on systemic therapy or who need systemic therapy at the discretion of the investigator. Systemic therapies include cyclosporine, systemic steroids, methotrexate, and dupilumab. Subjects who have been on cyclosporine, systemic steroids, or methotrexate in the month prior to initiation of study intervention or are unwilling to undergo a washout period. Subjects who have been on dupilumab in two months prior to initiation of study intervention or are unwilling to undergo a washout period. Subjects with a diagnosis of Scabies. Pregnant women Prisoners