Inclusion Criteria:  Ability to provide written informed consent Male or female aged 18-70 years Must be able to speak and read Danish Type 1 diabetes patients with HbA1c <48 mmol/mol (Case A) or >70 mmol/mol (Case B) CGM-documented frequent exposure to hypoglycaemia (Case A) or CGM without hypoglycaemia (Case B) for 6 days. A documented clinically relevant history of type 1 diabetes In insulin treatment regimen The subject must be willing and able to comply with trial protocol  Exclusion Criteria:  History of severe psychological condition History of severe heart disease History of epilepsy, former apoplexies and dementia History of muscle diseases History of liver disease History of malignancy unless a disease-free period exceeding 5 years Implants not compatible for MRI scans History of alcohol or drug abuse Pregnant or lactating woman