Inclusion Criteria:  o At least 18 years of age  Male or female patient who had DMEK within the past 1 to 7 weeks. Patient is able and willing to administer eye drops. Patient is able to comprehend and has signed the Informed Consent form. Patient is likely to complete the 11-month study duration.  Exclusion Criteria:  o A history of a previous rejection episode in the study eye  A patient exhibiting intraocular inflammation. A patient with a known sensitivity to any of the ingredients in the study medications A patient who has a condition (i.e., UNCONTROLLED systemic disease) or is in a situation which in the investigator's opinion may put the patient at significant risk, may confound the study results, or may interfere significantly with the patient's participation in the study A patient with abnormal eyelid function. A patient that is exhibiting active corneal ulceration, keratitis, or conjunctivitis, or who has a history of herpetic keratitis. Presence of any ocular disease that would interfere with the evaluation of the study treatment. However, patients with a history of cystoid macular edema, age-related macular degeneration, controlled glaucoma, corneal neovascularization, and other non-interfering comorbidities may be enrolled. A patient with a history of non-compliance with using prescribed medication. Patients who are pregnant or planning to become pregnant within the duration of the study