Adults aged 18 to 75 with UC, with initial diagnosis of UC >3 months prior to time of study enrollment visit Partial Mayo score of 4-10 with endoscopic subscore ≥2 on flexible sigmoidoscopy Permissible UC medications include oral or rectal administered mesalamines Corticosteroids must be discontinued at least 4 weeks before enrollment Documented negative C. difficile and GI PCR for enteric pathogens (BioFire) testing before commencement of fecal microbiota transplantation Previous documentation of ulcerative colitis based on colonoscopy/flexible sigmoidoscopy with compatible histology