Inclusion Criteria:  Pathologically confirmed adenocarcinoma of prostate Stage cT1-3N0M0 localized prostate cancer performed PSMA PET/CT and mpMRI before treatment No lymph nodes or distant metastasis Age ≥ 45 and < 85 years of age Karnofsky Performance Score ≥70 No previous pelvic radiation therapy (RT) No previous prostatectomy No previous invasive cancer (within 5 years before the prostate cancer diagnosis) Ability to understand character and individual consequences of the clinical trial Willing to sign the written informed consent; Informed consent must be signed before the enrollment in the trial  Exclusion Criteria:  No pathologically confirmed adenocarcinoma of the prostate Pelvic lymph node metastasis (N1) Distant metastasis (M1) Previous pelvic radiotherapy Previous prostatectomy