Inclusion Criteria:  Age at disease onset above 16 yrs old Patients diagnosed as according to 1984 modified New York criteria of AS .including radiographic and non-radiographic AS according to ASAS crteriae[22]. Psoriatic arthritis patients fulfilling the diagnostic criteria defined by the Classification Criteria of Psoriatic Arthritis (CASPAR[23]study and with a diagnosis confirmed by a rheumatologist  Exclusion Criteria:  Diabetes mellitus or use of antidiabetic medication. Heart failure, as defined by ejection fraction <50%. Renal disease. Chronic obstructive lung disease; pulmonary hypertension; pregnancy or obesity. Metabolic syndrome. History of cardiovascular, peripheral artery disease, or cerebrovascular events.