Inclusion Criteria:  Participants aged 18 to 70 years Participants must be outpatients with a primary diagnosis of Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) defined PTSD confirmed by the clinical interview PTSD is primary diagnosis  Exclusion Criteria:  Acute or unstable medical condition, behavioral or psychiatric disorder (other than PTSD) Suicidal behavior in the past 2 years or active suicidal ideation in the past 6 months Ongoing traumatic event or exposure to a traumatic event <3 months prior to Screening Index event > 12 years Index event is combat trauma