Inclusion Criteria:  Histologic evidence of ER/PR positive breast adenocarcinoma Postmenopausal women. Baseline LS and total hip BMD T-score > -2.0. No prior treatment with denosumab or IV bisphosphonates is allowed. No prior treatment with radiopharmaceuticals. Not pregnant and not nursing. Good dental health. ECOG performance status 0-2. Calculated creatinine clearance >= 30 mL/min. Corrected serum calcium >= 8.0 mg/dL (2.00 mmol/L) and < 11.6 mg/dL (2.90 mmol/L)  Exclusion Criteria:  Patients with dental problems. Patients with impaired renal functions Patients with osteopenia, or T- score is below -2.0 Patients with history of serious drug hypersensitivity or drug allergy.