Inclusion Criteria:  Age 18-70 years Living in the surroundings of Wageningen (max. 25 km) Stable body weight for past 6 months Suitable veins for insertion of cannula BMI 18.5-22 kg/m2 (lean subjects) BMI ≥ 30 kg/m2 (obese subjects)  Exclusion Criteria:  Use of cholesterol-lowering medication (e.g. statins) Use of diabetes medication (e.g. insulin, metformin) Use of antibiotics or anti-inflammatory medication (e.g. NSAIDS such as ibuprofen) Known allergy for any of the food components used in the study (milk, cream, sugars) Blood clotting disorders Current smokers Alcohol consumption of > 21 units per week Participation in another clinical trial at the same time Being an employee of Wageningen Food & Biobased Research