Inclusion Criteria:  At least one lesion on coronary artery branch greater than 2 mm in diameter assessed as 40-90% narrowing by visual estimation Invasive intracoronary FFR and RFR measurement using the Quantien system according to clinical decision  Exclusion Criteria:  Patients with acute coronary syndrome Left main disease Contraindication for adenosine Coronary artery bypass graft on the investigated vessel Severe renal insufficiency (estimated glomerular filtration rate <30 ml/min/1.73 m2) Coronary angiography and pressure recordings not suitable for evaluation