Inclusion Criteria:  Infants with moderate or severe hypoxic-ischemic encephalopathy (HIE) based on the modified Sarnat Exam on admission and has started to receive therapeutic hypothermia for 72 hours. Cared for in the Newborn and Infant Critical Care Unit (NICCU) at Children's Hospital Los Angeles (CHLA). Family lives within 60 miles of CHLA. One parent/legal guardian has provided signed and dated informed consent form agreeing to the child's participation and the parent's own participation.  Exclusion Criteria:  Infant born preterm. Infant with congenital anomalies, chromosomal or microarray abnormalities. Infant with microcephaly. Infants who have been redirected for comfort care. Infants who are medically unstable.