Inclusion Criteria:  A body mass index (BMI) in the range 18.0-30.0. Ability & willingness to provide written consent.  Exclusion Criteria:  Clinically relevant abnormal medical history, physical findings, laboratory values at pre-trial screening. History of bleeding disorders, coagulation variables or abnormal blood cell count. History of chronic illness. Impaired endocrine, thyroid, hepatic, renal or respiratory function, diabetes mellitus, coronary heart disease or history of any psychotic mental illness. History of adverse reaction or allergy to any drug. Use of aspirin, other non-steroidal anti-inflammatory drugs (NSAIDs), or any other medicine that affects platelet function or coagulation, or any prescription medicine, during the 28 days before the first dose of trial medication. History of drug or alcohol abuse Smoker or use of nicotine-containing products Blood pressure or heart rate at screening outside normal ranges.