Inclusion Criteria:  Age ≥18 years old and ≤75 years old Diagnosed as stable or unstable angina pectoris, asymptomatic myocardial ischemia or old myocardial infarction, or recent myocardial infarction in stable stage. Eligible for balloon dilatation or stent implantation. Subject (or legal guardian) understands the study requirements and procedures and provides written Informed Consent before any study tests or procedures are performed  Exclusion Criteria:  AMI occurred within 7 days before operation The subjects had congestive heart failure or the heart function was classified as NYHA/KillipIV. Left ventricular ejection fraction (LVEF) < 35% History of heart transplantation The subjects had severe arrhythmias, such as high-risk ventricular extrasystole and / or ventricular tachycardia. The subjects had stroke, gastrointestinal bleeding or active ulcers, or had a high risk of bleeding in the past 6 months. Active bleeding physique or blood coagulation disorder Known renal insufficiency（eGFR<30ml/min） Contraindicated to anticoagulants or antiplatelet agents Has a history of percutaneous coronary intervention (PCI) within 6 months before enrollment. Has contraindications for coronary artery bypass grafting known to be allergic to aspirin, heparin, contrast agents, paclitaxel and sirolimus Life expectancy less than 12 months, or unable to complete a 12-month follow-up Pregnant or lactating females, or who plan to become pregnant during a follow-up period of 1 year after operation The subjects have participated in other drug property studies or device studies that have not yet completed the main end point.  Angiographic Inclusion Criteria:  One target lesion (bifurcation lesion) in the coronary artery is allowed, and if there are coexistent non-bifurcated lesions requiring PCI intervention, only one lesion was accepted at most, and the target lesion should be treated after successful PCI treatment of non-target lesion. Target Lesion located in native coronary artery must be de novo Medina classification should be (1.1.1, 1.0.1, 0.1.1) Main branch of target lesion (%DS is ≥70% or ≥50% with clinical symptoms ) is suitable for stent implantation Target Lesion located in main branch should be covered by DES. Moreover, the residual stenosis ≤ 30%, TIMI flow is 3, no complications and branch vessel opening stenosis ≥ 70%. Reference vessel diameter of the branch is 2.0-4.0mm (by visual) Target lesion length ≤ 36mm (by visual)  Angiographic Exclusion Criteria:  Target or non-target lesion located in left main Subjects who have non-target lesions of bifurcation The target lesion is trifurcation or multifurcation lesion. Main branch of target lesion located within 3 mm from the ostium of LAD or LCx or RCA The branch lesion is a diffuse long lesion, which could't covered by one DCB. Main or side branch is occlusive lesion, which TIMI flow is 0. Aneurysm existed in the blood vessel at the target lesion Side branch severely calcified or tortuous The blood pressure was too low to tolerate intracoronary injection of ≥ 100ug nitroglycerin Failure pre-dilatation of the side branch ostium (residual stenosis > 30% ,the blood flow in TIMI is not up to grade 3, or has dissection of type C or above according to NHLBI grade)