Inclusion Criteria:  Medically healthy adult [ASA (American Society of Anesthesiologists) classification I-II], age ≥ 16 years old Preferably non-smoker, or previous smoker (quit ≥ 5 years), light smoker with less than 20 cigarettes/ day Therapeutic or strategic indications No allergies against local anasthesia (Articain, Mepivacain) and their preservatives (Natriummetabisulfid E223, natriumchlorid) Written consent of the patient No infected upper and lower third molars Third molars in 4 quadrants and located in maxilla/mandible (classification of Pell and Gregory/ Winter) and indication for extractions  Exclusion Criteria:  Medically compromised subjects (ASA classification III-V) General contraindications against third molar extractions (e.g. immunodeficiency, advanced systemic diseases, corticosteroid medication) Treatment or diseases that may have an effect on bone turnover or bone or non-mineralized tissue metabolism (e.g. Bisphosphonates or local radio-therapy) Patients with anticoagulant therapy Heavy smoker or previous heavy smoker (quit < 5 years; ≥ 20 cigarettes/day) Use of any form of antibiotics in the last 3 months or subjects requiring antibiotic prophylaxis prior to dental treatment Pregnant or breast feeding. Self declared intend to conceive. A pregnancy test performed for female patients. Subjects aged < 16 years old