Inclusion Criteria:  Age: up to 99 Years (Child, Adult, Older Adult) Sex: All; Families and patients with a history of renal hematuria; Those who signed the informed consent.  Exclusion Criteria:  Polycystic kidney disease, hypertensive nephropathy, etc.; Kidney biopsy is diagnosed as other primary/secondary kidney disease without type IV collagen-related kidney disease, including IgA nephropathy, membranous nephropathy, lupus nephritis, etc. Incomplete medical history or clinical data.