Inclusion Criteria:  Standard care patients for theranostic goal  Histological or cytological evidence of a diagnosis of metastatic or locally advanced solid tumor Tumor material available and usable for the analyses required by the study Request for genetic analysis to be performed at the initiation of the 1st or 2nd line of treatment Normal biological parameters Life expectancy ≥ 6 months Performance status ≤ 1 Social security affiliation Who have received information and agreed to participate  Patient from EX²TRICAN study  Histological or cytological evidence of a diagnosis of metastatic or locally advanced solid tumor Having cancer before age 40 Patient affiliated to social security Availability of a tumor sample if secondary functional studies are required Availability of the 2 parents when the trio approach is required Availability of affected relatives Who have received information and agreed to participate  Health professional  To be oncologist or geneticist or genetic counselor and able to be inform, prescribe and transmit the results of secondary data Working at university hospital center of dijon or cancerology center Georges Francois Leclerc at Dijon Who have received information and agreed to participate  Exclusion Criteria:  Standard care patients for theranostic goal  History of Human immunodeficiency virus infection History of Hepatitis B virus /Hepatitis C virus infection To be pregnant or likely to be or breastfeeding disorders psychiatric  Patient from EX²TRICAN study  Minor index cases Disorders psychiatric