Inclusion Criteria:  Female patients 18 years of age or older with known invasive or in-situ breast cancer (BC) diagnosed at an outside facility and presenting to MD Anderson for staging with imaging Female patients 18 years of age or older referred from outside institutions with imaging findings categorized as highly suspicious (Breast Imaging Reporting and Data System [BI-RADS] 5 or 4C) on outside imaging or on rereview by MD Anderson's radiologists and referred for staging at MD Anderson Cancer Center (MDACC) Willingness to participate in the study and ability to provide informed consent  Exclusion Criteria:  Breast surgery within 6 months Known allergy to iodine-containing contrast agents History of anaphylactic reaction to any substance that required hospitalization or IV placement Renal insufficiency; hyperthyroidism Detection of non-breast primary or metastatic cancer in the breast