Inclusion Criteria:  Diagnosis of stage II/III/IV and grade A/B generalized periodontitis; Presence of at least 20 teeth in the mouth; Signing the informed consent form.  Exclusion Criteria:  Presence of systemic conditions that contraindicate the periodontal procedure or influence the progression of the disease; Periodontal treatment history in the last six months; Use of antibiotics or probiotics in the last six months; Smoke more than 10 cigarettes a day; Pregnant or breastfeeding; Chronic use of anti-inflammatory drugs or medications that can alter the response of periodontal tissues; Need of antibiotic prophylaxis for dental procedures; Need of probiotic therapy.