Inclusion Criteria:  Newly diagnosed exocrine pancreatic cancer with pathology confirmed as adenocarcinoma Patient is a candidate for surgical resection of pancreatic cancer ≥ 18 years old at the time of informed consent ECOG Performance Status 0-2 Patients with or without neoadjuvant chemotherapy will be eligible Ability to provide written informed consent and HIPAA authorization Women of childbearing potential definition must have a negative pregnancy test within 14 days of registration. All women (regardless of sexual orientation, having undergone a tubal ligation, or remaining celibate by choice) are considered to have childbearing potential unless they meet one of the following criteria: Prior hysterectomy or bilateral oophorectomy; Has not had menses at any time in the preceding 24 consecutive months Adequate organ function for surgical therapy  Exclusion Criteria:  Patients with pancreatic malignant tumor histologically confirmed as neuroendocrine or any other type of malignancies Positive pregnancy test, pregnant, or breastfeeding Known hypersensitivity to any component of the formulation or substituted benzimidazoles Any other clinically significant laboratory abnormality that would compromise patient safety or the outcome of the study Any clinically significant and/or uncontrolled cardiac-related abnormality that would compromise patient safety or the outcome of the study Medical condition that might affect the absorption of study medications in the opinion of the investigator.