Inclusion Criteria:  Diagnosis of histopathologically proven locoregional advanced primary breast cancer:  Tumors > 5 cm (= T3) or Tumors with invasion of the skin or chest wall (= T4) or Any tumor with ≥ 4 axillary lymph nodes or ipsilateral internal mammary, infraclavicular or supraclavicular nodal involvement (= N2-3) Heterogeneously or extremely dense breasts as described by visual assessment on full-field digital mammograms: category C or D according to the ACR BI-RADS lexicon  Exclusion Criteria:  History of allergic reactions to iodinated contrast agents Pregnancy or breast feeding Treatment of thyroid disease with radioactive iodine Use of metformin Creatinine clearance < 45 ml/min Chronic or acutely worsening renal disease Patients who are declared incompetent