Inclusion Criteria:  Meet the criteria of hepatocellular carcinoma Patients who tested positive for hepatitis B surface antigen (HBsAg) for >6 months Meet the criteria of anemia Ages Eligible for Study: ≤75 years old; Informed consent from the patient.  Exclusion Criteria:  Patients with upper gastrointestinal bleeding within 3 months before enrollment; History of blood transfusion within 3 months before enrollment; Patient with other chronic hepatopathy, such as AIH, NAFLD, ALD; Serious problem of heart, lung, or kidney with severe dysfunction; Pregnant or child breast feeding women; Mental or cognitive disorders; Participating in other drug trials; Who are allergic to the study drug.