Inclusion Criteria:  All Patients with confirmed COVID-19 of either gender and aged 12 years and above.  Patients having Severe COVID 19 Disease. Severe disease is defined as patients with an oxygen saturation (SpO2) ≤94% on room air or requiring supplemental oxygen or requiring mechanical ventilation or requiring extracorporeal membrane oxygenation (ECMO).17  -  Exclusion Criteria:  Known severe allergic reaction to Remdesivir or to other antiviral drugs Patients already having other treatments like tocilizumab or other antiviral drugs Pregnancy or breastfeeding Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) >5 times upper normal limit Creatinine clearance <30ml/min Low platelet count <50,000/l