Inclusion Criteria:  ethnicity - Kazakhs in at least three generations active disease or a history of B-line ALL or B-NHL, established on the basis of morphological, cytochemical, immunophenotypic or immunohistochemical research methods with confirmation of the fact of the disease in medical documentation Signed voluntary informed consent of the legal representative to participate in the project  Exclusion Criteria:  Children suffering from other types of malignant neoplasms Children with B-linear leukemia and lymphomas with concomitant specified genetic and chromosomal diseases Children of non-Kazakh nationality Absence of signed informed consent or informed refusal of the legal representative to participate in the study before starting therapy