Inclusion Criteria:  age >65 general anesthesia using non-depolarizing neuromuscular blocker  Exclusion Criteria:  Patients with an ASA score greater than 3 Those with contraindications to anesthetic drugs Those with neuromuscular, neurological and psychiatric diseases Patients in whom TOF monitoring is not possible in the ulnar nerve region Patients with advanced renal failure Patients with advanced hepatic insufficiency Those with decompensated heart failure Patients with BMI<18 and BMI>30 Patients with uncontrolled hypertension, uncontrolled diabetes, pheochromocytoma, thyroid dysfunction Those who are incapable of reading and signing the consent form Patients who do not want to sign the consent form Patients deemed unsuitable by the investigator Those with chronic opioid use