Inclusion Criteria:  Have a body mass index (BMI) of ≥30-kilogram square meter (kg/m²) Have a BMI ≥27 kg/m² and <30 kg/m² with at least 1 of the following weight-related comorbidities eg; [Have hypertension, or dyslipidemia, cardiovascular disease] Have had a stable body weight for the 3 months prior to randomization (not more than 5% body weight gain and/or loss)  Exclusion Criteria:  Have any prior diagnosis of diabetes Have a prior or planned surgical treatment for obesity Have obesity induced by other endocrinological disorders or diagnosed monogenetic or syndromic forms of obesity Have renal impairment measured as estimated glomerular filtration rate (eGFR) <30 milliliter (mL)/minute (min)/1.73 m² Have a history of acute chronic pancreatitis Have a history of significant active or unstable Major Depressive Disorder (MDD) or other severe psychiatric disorder (for example, schizophrenia, bipolar disorder, or other serious mood or anxiety disorder) within the last 2 years Note: Participants with MDD or generalized anxiety disorder whose disease state is considered stable for the past 2 years and expected to remain stable throughout the course of the study, may be considered for inclusion if they are not on excluded medications.  Within 3 months prior to screening:  Have poorly controlled hypertension Have history of acute myocardial infarction Have history of cerebrovascular accident (stroke) Had hospitalization due to congestive heart failure (CHF) Have cancer Have human immunodeficiency virus (HIV) and/or positive HIV antibodies historically or at screening Have hepatitis B and/or positive hepatitis B surface antigen