Inclusion Criteria:  HIV infection group: a. The HIV positive diagnosis is clear; b. 18-80 years old; c. Has been vaccinated against the COVID-19 ; d. Volunteer to participate in the project; Healthy control group: a. HIV negative; b. Age 18-80 years old; c. The COVID-19 vaccination has been completed; d. Volunteer to participate in the project  Exclusion Criteria:  Previous confirmed case of COVID-19 confirmed contact history of COVID-19 vaccination contraindications.