Inclusion Criteria:  Age ≥18 years Maintenance hemodialysis 3×/week for ≥3 months and ≤3 years BMI <45 kg/m2 and stable weight (± 5 kg ["dry weight"]) over the preceding three months Signed informed consent  Exclusion Criteria:  Study specific:  Contraindications for MRI Hypersensitivity or Intolerance of Empagliflozin Participation in another clinical trial  Medical condition specific:  History of diabetic ketoacidosis Life expectancy < 1 year Substance abuse History of Type 1 diabetes mellitus Scheduled kidney transplant from a living donor Other significant disease or pathology, that might predispose that patient to an unacceptable risk or interferes with the study in the opinion of the investigator. Acute coronary syndrome during the last 30 days Existing treatments with SGLT2i within the last 6 months  Female specific:  Child bearing potential & unwilling / unable to use an acceptable method to avoid pregnancy for the entire study (estrogen and/or progesterone treatment). Pregnancy Breast feeding