Inclusion Criteria:  Informed consent Age 19 years or greater Cytologically or histologically confirmed pancreatic adenocarcinoma Locally advanced unresectable disease per National Comprehensive Cancer Network resectability criteria No active infection except chronic hepatitis on anti-viral therapy Eastern Cooperative Oncology Group performance status 0 or 1 Body weight > 30 kg Normal organ and bone marrow function  Exclusion Criteria:  Gastrointestinal obstruction Active gastrointestinal bleeding or ulcer Clinically significant cardiac disease or myocardial infarction within 6 months before the randomization Histology other than adenocarcinoma (adenosquamous or neuroendocrine tumors) Pregnancy or breastfeeding