Inclusion Criteria:  Persons of Kazakh nationality Age up to 59 years inclusive at the time of primary myocardial infarction Myocardial infarction was established in accordance with the EOC criteria: An increase and / or decrease in the level of cardiac troponin must be combined with at least one of the following: • Symptoms of myocardial ischemia • Newly occurring ischemic changes on the ECG • The appearance of a pathological Q wave • Identification according to imaging data methods of new areas of non-viable myocardium, or new areas of local contractility disorders of presumably ischemic etiology • Detection of a thrombus in the coronary arteries according to coronary angiography Presence of coronary angiography Persons able and willing to provide written informed consent;  Exclusion Criteria:  Age at primary myocardial infarction 60 years and older Heart defects, congenital and acquired Non-ischemic cardiomyopathies Autoimmune diseases Diabetes mellitus at the time of development of primary myocardial infarction Terminal stages of renal and hepatic failure