Inclusion Criteria:  All the patients undergoing elective CAG at Vajira hospital from October 2018 to March 2019 were included in the study older than 18 years old stable eGFR 15-60 mL/min/1.73m2 in last 3 months.  Exclusion Criteria:  dialysis-dependent post-kidney transplantation acute heart failure or critically ill history of contrast or turmeric allergy increasing of alanine aminotransferase (ALT) or alkaline phosphatase (ALP) more than three times of normal upper limits or post-cholecystectomy history of AKI (as evidence by sCr change ≥ 0.3 mg/dL) within 14 days before the study - using medication included NSAIDs, warfarin, immunosuppression, N-acetyl cysteine, ascorbic acid or contrast agents within 14 days before the study pregnancy or lactation o denied consent .