Inclusion Criteria:  Breast cancer surgery. Age 20 to 60 years. Female patients. At least 24 hours post-operative hospital admission. ASA (American society of anesthesiologist) physical status classification system І to Ш.  Exclusion Criteria:  • Morbid obesity (body mass index > 40).  Impossibility of anatomical structures identification by ultrasound in a satisfactory way (there can be no distinction in the interfacial plan between serratus and pectoral muscle). Opioids treatment before surgery or substance abuse. Sepsis and/or infection at the puncture site. Hemostasis disorders. Allergy to any of the drugs used in the study. Less than 24 hours postoperative hospital admission. Inability to communicate with the patient.