Inclusion Criteria:  Traumatic brain injury patients Age >= 18 years Admitted to the ICU  Within 72 hours after admission to the initial hospital:  ICP monitoring in place (parenchymal probe, ventricular catheter, or both) Requiring sedation  Exclusion Criteria:  Known pregnancy and/or lactation Imminent or actual brain death upon inclusion Allergy or intolerance to the study medication Pre-existing neurocognitive disorders, pre-existing congenital or non-congenital brain dysfunction. Inability to obtain informed consent Inclusion in an interventional randomised controlled trial of which the PI indicates that co-inclusion specifically in the BIKe study is prohibited. Therapy restriction code upon inclusion. Porphyria Glaucoma