Inclusion Criteria:  Symptom-free, bilaterally located third molars Medically healthy patient ≥ 16 years No allergies/intolerances against the investigational product/placebo Informed consent  Exclusion Criteria:  General contraindications to wisdom tooth extraction surgery (Former) heavy smoking Use of antibiotics within the last three months or patients requiring antibiotic treatment prior to surgery (Planned) Pregnancy/lactating