Inclusion Criteria:  diastolic heart failure (E/e' > 8, left ventricular ejection fraction (LVEF) => 50 %, dyspnea)  Exclusion Criteria:  nutritional supplements with polyamines acute myo-, endo- or pericarditis aortic valve stenosis (2nd degree) cardiomyopathy or severe left ventricular hypertrophy (Interventricular septal end diastolic thickness or posterior wall thickness > 17 mm) AV block (second degree) pulmonary hypertension thromboembolic event in the last six months anemia infection (with fever) within the last four weeks cancer