Inclusion Criteria:  Adults: men and women ≥ 18 years. Patients with a medical diagnosis of COPD based on a recent spirometry. Patients with a CAT score> 15, affecting COPD symptoms in a moderate-high way in the daily life of these patients. Minimum clinical stability period of 4 weeks before the start of the study. Patients who are trained to give informed consent. Patients must agree to perform study visits and procedures with precise instructions.  Exclusion Criteria:  BMI ≥ 40. Comorbidities, which due to their severity or progression, may interfere with the results, such as cancer, hematological disorders, severe heart or liver failure, kidney failure on dialysis, tuberculosis (TB) or AIDS, or other pulmonary pathologies such as pulmonary thromboembolism ( PE), pulmonary fibrosis, or relevant bronchiectasis. In Pulmonary Rehabilitation treatment or in treatment for smoking. Pregnancy or breastfeeding. Impossibility of the patient, due to a medical condition, to follow the study.