This project is a non-interventionary real world case follow-up registration. All registration data are from real clinical practice cases. The collected data include the following requirements:  Age ≥18 years old; Unresectable hepatocellular carcinoma confirmed by histological examination or clinical diagnosis; Plan or have received systemic therapy combined with Tislelizumab; No participation in other clinical studies; Access to Tislelizumab treatment and other clinical records.