Inclusion Criteria:  Have the ability to communicate orally or in writing and sign an informed consent form; Age from 18 to 60 years (the age of patients with mild to moderate COPD <65 years), regardless of gender; Meet the above-mentioned early diagnosis criteria for high-risk patients with COPD/early-stage COPD/mild to moderate COPD.  Exclusion Criteria:  Patients suffering from any of the following diseases: active tuberculosis, severe bronchiectasis, lung abscess, aspiration pneumonia, lung tumor, non-infectious interstitial lung disease, pulmonary edema, atelectasis, pneumothorax, pleural effusion , Pulmonary embolism, pulmonary eosinophilic infiltration, and pulmonary vasculitis; Patients with a history of tumors or patients with current tumors; The patient has severe renal impairment: creatinine clearance rate <30ml/min/1.73m2 or serum creatinine>265μmol/L (>3mg/dL); Patients suffering from liver disease or severe liver damage: ALT, AST> 2 times the upper limit of normal; pregnancy; Severe COPD, FEV1 predicted value ≤50%; Severe heart disease, such as coronary heart disease, heart failure, etc.; Severe coagulopathy: INR>1.4, PTT>40s, PLT<150x103 cells Bronchial Asthma; Severe alcoholism; diabetes; Have used antibiotics within two months, Used systemic and local hormones; Cannot sign the informed consent form;