Inclusion Criteria:  Adult ≥ 18 years ≤ 80 years (female or male). ASA I - II - III. Able to comprehend, sign and date the written informed consent document to participate in the clinical trial. Patient is scheduled for pancreaticoduodenectomy (Whipple's procedure).  Exclusion Criteria:  Allergy to the medication dobutamine. Renal insufficiency (SCr > 2 mg/dL). Severe heart failure (EF < 25%). Hemodynamic unstable patients. Atrial fibrillation. Sinus tachycardia > 100 bpm on pre-operative electrocardiogram. Sepsis. BMI > 40. Severe coagulopathy (INR > 2). Thrombocytopenia (< 80 x 103 /mcL). End stage liver disease and/or portal hypertension. Pregnancy and breastfeeding women.