Inclusion Criteria:  Patients aged 40 years or older undergoing screening colonoscopy for CRC Ability to provide written, informed consent (approved by EC) and understand the responsibilities of trial participation  Exclusion Criteria:  subjects at high risk for colorectal cancer subjects with a personal history of CRC, IBD or hereditary polyposis or non-polyposis syndromes patients with previous resection of the sigmoid rectum patients on anticoagulant therapy, which precludes resection / removal operations due to histopathological findings patients who perform an emergency colonoscopy