Inclusion Criteria:  Diagnosis of non-small cell lung cancer, both sexes, ECOG performance status (0-1), treatment virgin, eligible for immunotherapy.  Exclusion Criteria:  supplementation of PUFA n-3 in the last 6 months; weight loss> 10% in 6 months, chronic liver disease, previous chronic kidney disease, anorexia, decompensated diabetes mellitus and dementia.