Inclusion Criteria:  Adult patients (age ≥18 years at transplantation) Kidney and kidney pancreas simultaneous transplantation EBV seronegative patients (IgG anti EBNA, IgG anti VCA and IgM anti VCA negative) (from 6 months before transplantation to the day of transplantation, included) Patient who have given written informed consent Negative pregnancy test and use of contraception during all the study EBV positive donor Patient affiliated to a social security scheme  Exclusion criteria:  Patient with known HBV active infection Allergy to Rituximab Severe Immune deficiency Severe cardiac insufficiency Pregnant or lactating women Women of child bearing potential unless they are using a birth control method Patient under judicial protection or under guardianship Patient currently participating in another clinical trial investigating drugs. Observational studies are not considered as an exclusion criterion Any form of substance abuse, psychiatric disorder or condition, which, in the opinion of the investigator, is incompatible with the participation in the study Unlikely to comply with the visits scheduled in the protocol.  Exclusion Criteria:  -