Inclusion Criteria:  Healthy Age 20 - 60 years Written informed consent  Exclusion Criteria:  severe gastrointestinal disease or known malabsorption use of proton pump inhibitors malignancies rheumatoid diseases metabolic syndrome acute or chronic infections or inflammatory diseases use of medications or supplements to interfere with immune function alcohol and/or drug abuse or addiction dependent relationship with the project manager or his or her employees pregnancy or breastfeeding chronic illness or regular use of medication (except hormonal contraception) smoker