Inclusion Criteria:  People at high cardiovascular risk. Clinical diagnosis of hypertension Clinical diagnosis of hyperlipidemia Clinical diagnosis of type 2 diabetes Clinical diagnosis of arrhythmia Clinical diagnosis of coronary artery disease Patients at the cardiology clinic.  Exclusion Criteria:  People who have been diagnosed by a doctor as unsuitable for vaccination. People with serious injuries or catastrophic illness, such as cancer patients. People who stay in bed for a long time and cannot take care of themselves.