Inclusion Criteria:  18-75 years old patients with pacemaker implantation for the first time, 3-6 months after operation stable condition, independent walking ability.  Exclusion Criteria:  Cognitive impairment; ICD, CRT / Crtd implanted, patients with neurogenic syncope; Atrial tachycardia, atrial fibrillation, NYHA class II or above, difficult to control hypertension; Musculoskeletal disease limiting activity nervous system disease, severe respiratory disease, Patients with acute inflammation, cancer and other diseases uncontrolled.