Key Inclusion Criteria:  Age ≥ 18 years on the day of signing the ICF (or the legal age of consent in the jurisdiction in which the study is taking place). Participant has newly diagnosed, histologically confirmed, locally advanced, Stage III unresectable NSCLC. Measurable disease as assessed by RECIST v1.1. Eastern Co-operative Oncology Group (ECOG) Performance Status of 0 or 1. Patients must have adequate organ function  Key Exclusion Criteria:  Any prior therapy for lung cancer, including but not limited to chemotherapy, radiotherapy, targeted therapy, biologic therapy, or immunotherapy. Any prior radiotherapy to the thorax, including radiotherapy to the esophagus, mediastinum, or for breast cancer. Prior therapy with an anti-PD-1, anti-PD-L1, anti-PD-L2, TIGIT or any other antibody or drug specifically targeting T-cell costimulation or checkpoint pathways. Diagnosed with NSCLC that harbors an EGFR-sensitizing mutation or ALK gene translocation. Active autoimmune diseases or history of autoimmune diseases that may relapse. Any condition that required systemic treatment with either corticosteroids (> 10 mg daily of prednisone or equivalent) or other immunosuppressive medication ≤ 14 days before the first dose of study treatment. Infection (including tuberculosis infection, etc) requiring systemic antibacterial, antifungal or antiviral therapy within 14 days before the first dose of study treatment.  NOTE: Other protocol Inclusion/Exclusion criteria may apply.