Inclusion Criteria:  Signed the informed consent. Female aged between 18 and 70 years. Pathologically diagnosed operable breast cancer. WHO Eastern Cooperative Oncology Group (ECOG) performance status of 0-1. Cancer located in the upper inner quadrant; Single tumor or multiple tumors in the same quadrant. The important organ functions meet the following criteria: WBC >=3.0 x 10^9/L; Neutrophilic granulocytes >=1.5×10^9/L; Platelet >=100 x 10^9/L; Hb >=9 g/dL; Total bilirubin no more than 1.5 times the normal upper limit (ULN); AST and ALT no more than 1.5 times ULN; AKP no more than 2.5 times ULN; Serum creatinine no more than 1.5 times ULN or Clearance rate of creatinine >= 60ml/min; Thyroid stimulating hormone (TSH) <= ULN (T3, T4 levels need to be detected simultaneously if abnormalities, the patient can be included if T3, T4 levels is normal); LVEF basement >= 50%. Adjust to the criteria of breast conserving surgery.  Exclusion Criteria:  Multifocal or multicentric disease. Tumor localized in the central quadrant or the distance to the nipple < 2 cm； Diffused calcifications with fine plemorphic or fine linear or fine-linear branching morphology. The ratio of tumor to breast > 20%; The diameter of tumor is up to 4 cm; Women in the early or intermediate stage of pregnancy; Prior history of breast radiation; Any severe comorbidities, inability to give informed consent or unavailability for follow-up.