Inclusion Criteria:  Any patient who are willing to participate and signs informed consent. Any patient with rifampicin resistant tuberculosis confirmed by phenotypic or molecular drug sensitivity test.  Exclusion Criteria:  Any regimen that does not conform to a shorter all-oral regimen composed of 4-5 drugs(BDQ, LZD, FQs, Cs, Cfz, Z, Dlm, INH). Combined extrapulmonary tuberculosis(except for tuberculous pleuritis, endobronchial tuberculosis and tubercular lymphadenitis).