Inclusion Criteria:  Subjects who completed the 2-year RCT study of carvedilol in HBV cirrhotic patients with anti-viral therapy; Subjects who are willing to participate the extension study.  Exclusion Criteria:  Subjects who refused to receive 2-year EGD examination during the previous RCT study; Subjects who could not compliance with the protocol judged by investigators; Subjects who are not suitable for the study judged by investigators.