Inclusion Criteria:  Adult (≥18 years of age) All admitted patients with severe or critical COVID-19 Confirmed diagnosis of COVID-19 through RT-PCR (attach report) and/or HRCT Chest Patients at high risk of coagulopathy demonstrating signs of micro-thrombi induced organ dysfunction or strongly suspected macro thromboembolism  Exclusion Criteria:  High risk of bleeding as judged by treating physicians Contra-indication to therapeutic anti coagulation Platelets < 50,000 (attach report) INR >1.5 Evidence of current or recent bleeding