Inclusion Criteria:  age 18-65 years; confirmed cirrhosis based on clinical or pathological criteria; no history of grade 1-4 hepatic encephalopathy; with written informed consent.  Exclusion Criteria:  with other neurological or mental diseases (such as Alzheimer's disease, Parkinson's disease, etc.); with alcohol or drug addiction and unstable vital signs; with liver cancer or other malignant tumors; fail to comply with psychological tests; incomplete data collection.