Inclusion Criteria:  Age ≥18 years, ≤80 years Urea breath test (UBT) was positive for Hp infection; WIthout any anti-Hp treatment before Endoscopy was performed within 1 month Understanding the purpose and procedure of the study, voluntarily participating in the study and signing a written informed consent.  Exclusion Criteria:  Allergic to drugs used in this clinical study; Using PPI, histamine H2 receptor antagonist, antibiotics, bismuth, probiotics or drugs with antibacterial effects within 4 weeks before treatment. Using adrenal corticosteroids, non-steroidal anti-inflammatory drugs and anticoagulants The disease or clinical condition that may interfere with the treatment evaluation of the study, such as liver disease, cardiovascular disease, lung disease, kidney disease, metabolic disease, psychiatric disease, or malignant tumor Pregnant or lactating women Participated in other clinical studies within 3 months prior to the registration of this clinical study Suspected history of antibiotic abuse Patients with craniocerebral injury, mental illness or epilepsy who cannot communicate with others or other diseases that may affect follow-up