Inclusion Criteria:  Patient aged ≥ 18 years Informed, written consent obtained from patient Patient having the rights to Frenc social insurrance For women of childbearing potential : any effective contraceptive is required Type 1 or 2 diabetic patients Diabetic patients treated non-surgically for an osteomyelitis of the forefoot affecting only one osteoarticular part/radial supported by adequate diagnostic imaging and bone biopsy performed through uninfected tissue. Two peripheral pulses or transcutaneous oxygen tension measurement (TcPO2 > 30mmHg) or ankle brachial index (ABI > 0.9) Patient without antibiotherapy during 2 weeks before D1. Glycated hemoglobin (HbA1C) < 12% ( measured maximum 2 months before D1) Use of offloading boot for diabetic foot is feasible  Exclusion Criteria:  Bone fragmentation, articular destruction requiring bone resection or amputation. Gangrene More than one osteoarticular part/radial affected Contraindication for the use of offloading boot Contraindication for bone biopsy Contraindication for the full course of antibiotics (allergy or based on RCP) Other drug-drug interaction that contraindicated the full course of antibiotics Charcot foot Patient undergoing radiotherapy of chimiotherapy for malignant neoplasms Hepatic insufficiency (ASAT and/or ALAT > 3 times the normal level) Any disease or behaviour making impossible to follow the protocol or difficult to interpret the results Any disease or context making difficult to allow regular monitoring of the patient Participation in other interventional research during the study Curator or guardianship of patient placed under judicial protection Pregnancy or lactating women