Inclusion Criteria:  Obtention of a written informed consent. Patient with histologically proved cholangiocarcinoma ; histologic diagnosis must be proved by biliary brushing, bile cytology, endobiliary biopsy under Spyglass, or by EUS-FNA. Patient with Karnofsky score > 60， ECOG>level 2 Patient capable of fill in the quality of life questionnaire For the first time treatment CT, MRCP, EUS and other examinations indicate that the tumor has locally infiltrated large blood vessels and cannot be surgically removed  Exclusion Criteria  No written informed consent Patients under or already treated by radiotherapy or chemotherapy treatment for cholangiocarcinoma. Pregnant, parturient or breastfeeding women Serious abnormalities in liver and kidney function and coagulation function The ERCP guide wire cannot pass the stricture due to severe biliary stricture Merge with other malignant tumors Use other treatments that may affect the observation, such as radioactive particles or seed stent implantation, P53 injection, oral chemotherapy, interventional therapy, etc.