Inclusion Criteria:  1. Diagnosis of glioblastoma confirmed by histology 2. Age: 18-75 years old 3. Single lesion located in one hemisphere with a diameter between 2 and 6 centimeters 4. No prior anticancer therapy for glioblastoma besides biopsy. 5. ECOG PS：0-2 point  Exclusion Criteria:  1. Infra-tentorial tumor or tumor involves the ependymal surface. 2. Nonmeasurable disease. 3. Evidence of uncontrolled intracranial pressure. 4. Severe heart, brain, and lung diseases. 5.Severe hepatic or renal dysfunction. 6. Uncontrolled, active infection. 7. Severe clotting dysfunction. 8. Pregnant. 9. Uncontrolled hypertension. 10. Participated in any other clinical treatment trial within 4 weeks before randomization. 11. Severe vascular diseases within 6 months before randomization. 12. Participants who received major surgical treatment within 4 weeks or were expected to be treated during the trial.