The inclusion criteria for the subjects in the indolent cohort will be:  a local disease with Gleason ≤ 7 (3+4, i.e. more differentiated tissue is found in diagnostic biopsies, better overall prognosis) no metastasis whatsoever during the follow-up;  The inclusion criteria in the early-metastatic aggressive cohort will be:  an advanced prostatic neoplasia with Gleason score ≥ 7 (4+3, i.e. less differentiated tissue is found in diagnostic biopsies, worse overall prognosis) multiple synchronous or metachronous metastasis.  Exclusion Criteria:  insufficient material on the tissue biopsy to be left in archives for further evaluations/analyses; insufficient amount of tumor cells at baseline;