Inclusion Criteria:  Men and women age 18 or older Hospitalized and requiring medical care for COVID-19 Presenting respiratory failure cause by COVID 19 requiring oxygen and/or mechanical ventilation support With radiographic evidence of pulmonary infiltrate Able to give informed consent or, if unable to do so regarding the medical condition, having relatives able of consenting for the patient  Exclusion Criteria:  Pregnancy Patients with pre-existing terminal condition with life expectancy < 6 months Patients with pre-existing severe lung disease requiring home O2 History of seizure disorder History of adverse reaction to antihistamines or to Cyproheptadine