Inclusion Criteria:  Age: 50-70-years old BMI: 28-40  Exclusion Criteria:  All drugs that could affect the outcome HbA1c > 48 mmol/mol Known heart failure og episodes of acute myocardial infarction Liver disease ALAT > higher than 3 times of the normal level Kidney disease eGFR < 60 ml/min Blood donation in the last 3 months before inclusion Participation in other studies with radiation in the last 6 months Alcohol addiction