Inclusion Criteria for All the Participants:  40-75 years old Ability to comply with study procedures Ability to provide a written informed consent  Exclusion Criteria for All the Participants:  Pregnancy or lactating women Recipients of organ transplant or prior non-autologous (allogeneic) bone marrow transplant or stem cell transplant Recipients of blood transfusion within 7 days prior to study blood draw Recipients of anti-microbial therapy within 14 days prior to study blood draw Recipients of any anti-cancer therapy within 30 days prior to study blood draw, due to diseases other than cancer  Inclusion Criteria for Cancer Arm Participants:  Confirmed diagnosis or highly suspicious cases of hepatobiliary malignancies No prior or ongoing anti-cancer therapy (local or systematic) prior to study blood draw  Exclusion Criteria for Cancer Arm Participants:  Current diagnosis of other malignancies or multiple primary tumors Diagnosis of benign diseases by histopathological assessments Inability to characterize whether the lesion is malignant or benign Prior or ongoing treatment of cancer  Inclusion Criteria for Benign Diseases Arm Participants:  Confirmed diagnosis of benign diseases of the hepatobiliary system No prior radical treatment of the benign diseases prior to study blood draw  Exclusion Criteria for Benign Diseases Arm Participants:  Current or history of malignancies or precancerous lesions No confirmed diagnosis or inability to characterize a benign disease