Inclusion Criteria:  Participant must be willing to share medical records and relevant medical information pertaining to the medical history of urinary tract infections (UTIs) and to the medical events identified as suspected cases of invasive extraintestinal pathogenic Escherichia coli disease (IED), UTI, or acute bacterial prostatitis (ABP) occurring during the study observation period Participant must have a history of UTI in the past 2 years that is documented in the medical records. In case of a recent history of UTI, the condition must have resolved greater than (>)14 days prior to randomization Before randomization, participants who were born female must be either postmenopausal or permanently sterile, and not intending to conceive by any methods Participant must be willing to provide verifiable identification, has means to be contacted and to contact the investigator during the study Participant or his/her designated caregiver must be able to work with smartphones/tablets/computers  Exclusion Criteria:  Participant has end-stage renal disease for which dialysis is required Participant has a contraindication to intramuscular (IM) injections and blood draws example, bleeding disorders or difficulty to perform blood draws Chronic use of antimicrobials. In case of prolonged antimicrobial treatment (> 3 weeks) or chronic use of antimicrobials, the last dose must have been administered > 60 days prior to randomization Participant has a history of acute polyneuropathy (example, Guillain-barre syndrome) or chronic inflammatory demyelinating polyneuropathy Participant has received any Escherichia coli (E. coli) or extraintestinal pathogenic Escherichia coli (ExPEC) vaccine