Inclusion Criteria:  Objective evidence of coronary heart disease risk factors Or angina pectoris symptoms Or ECG ischemic changes Or elevated myocardial enzymes, myocardial radionuclide scanning showing myocardial filling defect, coronary CT showing coronary stenosis ≥ 50%  Exclusion Criteria:  Older than 80 years and younger than 18 years old, Aortic dissection Pulmonary embolism Malignant tumor Autoimmune diseases Systemic systemic diseases Severe infectious diseases Trauma, surgery in the last three months Myocarditis, cardiomyopathy, pericarditis, severe congenital heart disease Syphilis Human immunodeficiency virus / acquired immunodeficiency syndrome Hepatitis B and hepatitis C