Inclusion Criteria:  Patients aged 10-70 years old; The symptoms lasted for at least 3 months; With or without cataclysm; MSLT showed that the sleep latency was less than or equal to 8 min, there were two or more times of sleep, the onset of REM sleep; Somnolence can not be explained by other diseases, such as insufficient sleep, OSAHS, delayed sleep phase, drug or drug use, etc.  Exclusion Criteria:  Somnolence was caused by sleep disorders, central nervous system diseases, brain trauma and other non narcolepsy; Recent lack of sleep or irregular sleep; PSG and MSLT examination can not be diagnosed as narcolepsy; Poor compliance, taking drugs or food and beverage containing central inhibitory components during the trial; Severe neuropsychiatric disorders can not cooperate with the examination; Patients with history of rheumatism, diabetes, ankylosing spondylitis and other HLA related diseases.