Inclusion Criteria:  Chronic use of any PPIs, either original brand or generic Absence of conditions that contraindicate the cessation of PPIs, such as active or recent peptic ulcer, active or recent upper digestive bleeding, regular use of salicylates or non-steroidal anti-inflammatory drugs, moderate to severe reflux esophagitis, and sliding hiatal hernia greater than 3 cm Formal agreement to participate  Exclusion Criteria:  Uncompensated acute and chronic morbidities Gastroesophageal surgery Cognitive deficit