Inclusion Criteria:  FIT concentration of 20 ug Hb/g or higher (Italy) or 47 ug Hb/g or higher (Netherlands) in the national CRC screening program as reason for referral. Age between 55 and 75 years (Netherlands) or 50 and 69 years (Italy)  Exclusion Criteria:  No signed informed consent History or current treatment for colorectal cancer History of inflammatory bowel disease History of other condition for which colonoscopy surveillance is planned within the next 5 years.