Inclusion Criteria:  History of limb amputation with limb-amputation surgery at least 6 months ago Have a prosthetic device  4. HDSS of 3 or greater (at screening) 5. ASDD-m Item 2 severity score >= 4 (at screening) 6. PFFQ score >= 4 (at screening)  Exclusion Criteria:  Open sores or wounds on residual limb (at screening and baseline) Known sensitivity to glycopyrronium tosylate or other component of Qbrexza Pregnant or lactating. Use of botulinum toxin within 1 year of the baseline visit Use of topical aluminum chloride within 1 month of the baseline visit Any significant concurrent condition that could adversely affect the patient's participation and/or the assessment of the safety and efficacy in the study in the opinion of the investigator