Inclusion Criteria:  Neonates and infants with CHD undergoing CPB for corrective surgery Age <1 year old  Exclusion Criteria:  Requirement of inhaled NO immediately prior to surgery Emergency surgery Severe developmental delay at baseline defined as a score of ≥ 4 (severe disability) on the Pediatric Cerebral Performance Category (PCPC) Scale, referencing cognitive status prior to critical illness Pre-existing renal disease Inability to understand English or deafness that will preclude delirium evaluation. The inability to understand English in verbal participants will not result in exclusion when the research staff is proficient and/or translation services are actively available in that particular language.