Inclusion Criteria:  ability to give written consent. Diagnosed advance cancer specifically gastrointestinal tract (GIT) cancer, Lung cancer and Breast cancer etc. (stage 2 and 3). Intensity of fatigue ≥4 out of 10 on fatigue Numerical Rating Scale in first visit observation Survival expectancy more than one month, Functional status allowing the participants to participate in the proposed therapy.  Exclusion Criteria:  Anemia (Hb ≤ 8g/dl), Existence of other comorbidities causing fatigue (i.e. Parkinson's, Multiple sclerosis, Heart failure), Infection requiring antibodies bone metastases, thrombocytopenia (<50×109/l), myocardial infarction within the past three months uncontrolled hypertension (diastolic pressure >95 mm Hg).