Inclusion Criteria:  Male or female patients aged ≥ 18 years at time of proposal study, Histologically confirmed non-small cell lung carcinoma, No previous treatment for NSCLC, Indication to EGFR status determination following HAS recommendation, Voluntary signed and dated written informed consent prior to any study specific procedure Patients with a social security in compliance with the French Law.  Exclusion Criteria:  Treatment for advanced NSCLC started before liquid biopsy sampling. Involvement in the planning and/or conduct of the study (applies to both Investigator staff and/or staff at the study site).