Inclusion Criteria:  Very premature infants born with a gestational age between 23+0 - 31+6 weeks； Admitted to both centers during 3 years from January 1, 2018 to December 31, 2020.  Exclusion Criteria:  Infants not born at QHH or SZH (out born); Infants who had major congenital anomalies; Infants ho were early transferred out.