Inclusion Criteria:  Information to the patient and signed informed consent; Locally advanced breast cancer that is a candidate for neoadjuvant therapy; Histological diagnosis of localized invasive breast carcinoma, confirmed by the pathologist, with or without expression of hormone receptors, and/or with the presence of HER-2.  Exclusion Criteria:  Metastatic breast cancer (Stage IV); Additional invasive malignant disease; Known psychiatric or substance abuse disorders that may interfere with cooperation with study requirements; Presents any organic condition that makes it impossible to carry out chemotherapy treatment; Pregnant or lactating women Received previous treatment for breast cancer.