Inclusion Criteria:  Patients aged 50 years and older with a recent fracture that is being evaluated at the FLS at VieCuri MC. Patients who understand the conditions of the study and are willing and able to comply with the scheduled biochemical study procedures Patients who signed the Ethics Committee approved specific Informed Consent Form prior to inclusion.  Exclusion Criteria:  Patients with malignancy metastatic to the bone. Patients with osteomyelitis. Patients with fractures due to failure of a prosthesis. Patients, who as judged by the Principal Investigator, are mentally incompetent. Patients who are compos mentis and understand the patient information, will not be considered mentally incompetent