Inclusion Criteria:  Children aged 6 months to 15 years, regardless of immunization status. Child with a major sickle cell syndrome (SS, SC, S+, S°, SE) followed in one of the centers of competence or reference for rare diseases (CRMR) " Major sickle cell syndromes, Thalassemias and other rare pathologies of the Red Blood Cell and Erythropoiesis " in Ile de France. Children who are not subject to legal protection measures. Child affiliated to a social security system. Signed informed consent  Exclusion Criteria:  Sickle cell child with a febrile syndrome at the time of sampling or hospitalized for any reason. Child having received antibiotic therapy other than oracillin in the 7 days preceding the nasopharyngeal swab. Child already included in the observation period (only 1 nasopharyngeal swab per patient). Other hemoglobinopathies and heterozygous AS or AC patients. Patients already involved in a therapeutic protocol or in the exclusion period following a previous research. Patients under AME or without social security coverage.