Inclusion Criteria:  Diagnosis of idiopathic PD (Clinically Probable PD) H&Y OFF 1-3 at Baseline Visit  Exclusion Criteria:  Chronic gastrointestinal disease (IBS allowed, celiac disease allowed if on gluten free diet, gastritis allowed) Any previous major gastrointestinal surgery that may alter gastrointestinal physiology Any abdominal surgery in the last 3 months Major genital and/or rectum prolapse Active autoimmune disease Active cancer within 5 years (allowed: basalioma and successfully removed carcinoma in situ) Immune deficiency HIV infection Antibiotic use in last 3 months before baseline visit Dementia as indicated by Moca <21p Psychosis Active significant impulse control disorder (by interview and medical records) Major depression as indicated by BDI-II >28 Pregnancy Alcohol or drug abuse Negative dysbiosis test result Iodine allergy Deep brain stimulation or Duodopa/Lecigon treatment Inability to interrupt regular use of NSAIDs for at least one month before permeability assessments