Inclusion Criteria:  Diagnosis of non-specific low back pain; Aged between 18 and 65,male and female; Duration of low back pain as the main symptom for at least 12 weeks; pain intensity with NRS score equals or more than 4; X-ray or CT on low back helped to confirm no lumbar diseases; Ability to understand and complete the questionnaires; Any treatments aiming to CNLBP need more than 1 month washout period; Volunteer to participate in the study and informed consent form.  Exclusion Criteria:  Sciatica, myelopathy, displacement, or radiculopathy due to lumbar intervertebral disc disorders or Spondylolisthesis； Chronic low back pain caused by local disease (e.g., lumbar fracture, lumbar tumor, lumbar tuberculosis, lumbar spine surgery or trauma)； Immune diseases such as rheumatoid joints and ankylosing spondylitis； Severe primary disease such as cardiovascular, lung, kidney, and hematopoietic disease; Pregnant or lactating women; patients with skin injury; Allergy or intolerance to Non-steroidal anti-inflammatory drug (e.g., asthma, gastrointestinal ulcers, and bleeding); Mental illness； Poor compliance of examination and treatment.