Inclusion Criteria:  Has laboratory-confirmed SARS-CoV-2 infection as determined by polymerase chain reaction (PCR) or other commercial or public health assay in any specimen, as documented by either of the following:  PCR positive in sample collected < 72 hours prior to consent; PCR positive in sample collected ≥ 72 hours prior to consent, with inability to obtain a repeat sample (e.g. due to lack of testing supplies, or limited testing capacity, or results taking >24 hours, etc.) or progressive disease suggestive of ongoing SARS-CoV-2 infection;  At least 1 of the following symptoms:  o Fever, cough, sore throat, malaise, headache, muscle pain, dyspnea at rest or with exertion, confusion, or respiratory distress;  A PaO2/FiO2 ≤200 recorded in the 24 hours before consent. The PaO2/FiO2 can be imputed from pulse oximetry; Oxygen therapy being administered via HFNC or NIV The presence of a respiratory infiltrate or abnormality consistent with pneumonia that is documented by either a CXR or CT scan of the lungs; The patient is ≥18 years of age; A female patient of childbearing potential must not attempt to become pregnant for 180 days, and if sexually active with a male partner, is willing to practice acceptable methods of birth control for 180 days after the last dose of study drug; A male patient who is sexually active with a female partner of childbearing potential is willing to practice acceptable methods of birth control for 180 days after the last dose of study drug. A male patient must not donate sperm for 180 days; The patient is willing and able to, or has a legal authorized representative (LAR) who is willing and able to, provide informed consent to participate, and to cooperate with all aspects of the protocol.  Exclusion Criteria:  Do Not Intubate order; PaO2/FiO2 ≤75 recorded at the time of consent. The PaO2/FiO2 can be imputed from pulse oximetry; Receiving IMV via endotracheal intubation or tracheostomy; Receiving ECMO; Shock defined by the use of vasopressors;  Known history of:  Organ or hematologic transplant; HIV; Active hepatitis B, or hepatitis C infection;  Current treatment with:  Chemotherapy; Immunosuppressive medications or immunotherapy (see protocol (Section 5.3) for list of prohibited immunosuppressive medications and immunotherapy) at the time of consent; Hemodialysis or Peritoneal Dialysis; Known to be pregnant or is nursing; Currently participating in another study of an investigational drug or therapeutic medical device at the time of consent; Known allergy to eggs or any of the excipients in study drug.