Inclusion Criteria:  Histologically documented diagnosis of metastatic/locally advanced melanoma, hormone-refractory breast cancer, RCC and UC, SCCHN, SCC or NSCLC, stage III resectable NSCLC will also be included Will and ability to comply with the protocol Willingness and ability to provide an adequate archival Formalin- Fixed Paraffin-Embedded (FFPE) tumor sample available for exploratory biomarker analysis Age from 18 to 90 years at the time of recruitment ECOG Performance Status < 2 Understanding and signature of the informed consent  Exclusion Criteria:  Known history of HIV infection Serious neurological or psychiatric disorders Pregnancy or lactation Inability or unwillingness of participant to give written informed consent Inability or unwillingness to be regularly followed up at the enrolling center