Inclusion Criteria:  10% of sites with survey depth 5 mm Comparable pockets in 4 mouth quadrants Health at systemic level  Exclusion Criteria:  Changes in oral mucosa Depth at the poll 5 mm Presence of removable prostheses or orthodontic equipment Allergies to even a single component of a product in testing• Antibiotic-based treatments during the 6 months preceding the start of testing History of previous periodontal treatments in the 12 months preceding the start of the study