Inclusion Criteria:  Subject who met 1977 or 2015 ACR (American College of Rheumatology) classification of Gout and has a serum acid ≥ 480 μmol/L at screening; 2、18 kg/m2 ≤ Body mass index (BMI) ≤ 35 kg/m2.  Exclusion Criteria:  Subject who is pregnant or breastfeeding; Alanine aminotransferase or Aspartate aminotransferase or total bilirubin>1.5 upper normal limit; Subject with a positive test for HLA-B*5801; Estimated glomerular filtration rate (MDRD formula) <60ml/min; HbA1c≥8%; Subject with known hypersensitivity or allergy to SHR4640 and allopurinol, or any component of SHR4640; Subject with kidney stones or suspicion of kidney stones; Subject who has acute gout flares within 2 weeks before randomization; Subject with a history of malignancy within the previous 5 years; Subject with a history of active peptic ulcer within a year; Subject with a history of xanthine urine.