Inclusion Criteria:  Have given the signed informed consent form. Confirmed diagnosis of COVID-19 infection by PCR with mild symptoms. Patients who attend the primary care respiratory care module in the participating units and who have symptoms suggestive of COVID-19, who comply with the current operational definition. With or without comorbidities such as hypertension, controlled diabetes mellitus, cardiovascular or respiratory diseases. Controlled diabetes will be considered to be that which is evidenced by results of glycosylated hemoglobin less than 7% in the last 3 tables, whether it is reported in your beneficiary file or by external laboratory results. Electrocardiogram (ECG) normal or with variations without clinical relevance, with QT interval <450 ms. No contraindication to study drugs (history of hypersensitivity to study drugs, including macrolides, patients with renal failure (eGFR <40 mL / min) or on renal replacement therapy, patients with a history of retinopathy or macular degeneration.  Exclusion Criteria:  Patients who are participating in studies with investigational drugs. Pregnancy or breastfeeding. Type 1 diabetes % Type II diabetes mellitus with glycated hemoglobin greater than 7%. Patients requiring hospitalization or assisted mechanical ventilation Cardiac disorders with cardiac conduction delay (QT segment ≥ 450 ms