Inclusion Criteria:  Patients with cirrhosis who have been referred for a procedure where HVPG is obtained.  Exclusion Criteria:  Patient is pregnant, breast-feeding, or planning to become pregnant during the course of the study Patient is unwilling or unable to sign and date the informed consent Patient is unwilling to comply with the follow-up study schedule Previous total or partial splenectomy Non-cirrhotic portal hypertension Known history of spontaneous bacterial peritonitis (SBP) within the last three months irrespective of treatment for SBP Patients with known infection which is not controlled by medical intervention Portopulmonary hypertension Cardiac decompensation Pre-sinusoidal liver disease Cholestatic liver disease Patient who received endoscopic treatment for upper gastrointestinal (GI) variceal bleeding within the past 7 days Patients with current hepatocellular carcinoma (HCC)