Inclusion Criteria:  Patients older than 18 years of age with the diagnosis of calcific aortic stenosis, aortic-jet velocity≥2m/s，<4m/s or mean aortic-valve pressure gradients≥20mmHg，<40mmHg, or aortic-jet velocity≥4m/s or mean aortic-valve pressure gradients≥40mmHg on echocardiography, and the patient has no symptoms and/or signs related to aortic valve stenosis and the exercise treadmill test is negative. Patients with moderate to very high cardiovascular risk require long-term use of statins and after 2 weeks of conventional intensive lipid-lowering therapy , the level of LDL-C is still≥1.8mmol/L and/or L(a)>50mg/dL.  Exclusion Criteria:  Cannot maintain the use of PCSK9 inhibitors for about 12 months Child-bearing potential without contraception Active or chronic liver disease History of alcohol or drug abuse Severe mitral-valve stenosis (mitral-valve area<1 cm2) Severe mitral or aortic regurgitation Left ventricular dysfunction (ejection fraction<35%), Planned aortic-valve replacement Intolerance of statins or PCSK9 inhibitors The presence of a permanent pacemaker or cardiodefibrillator.