Inclusion Criteria  To be eligible for this study, participants must meet all the following:  Age  55 to 80 years old inclusive at the time of signing the Informed Consent Form (ICF).  Type of Participants  In stable and good general health, without significant medical illness, based on medical history, physical examination and vital signs at screening  Safety laboratory values within the following range criteria at screening:  Laboratory value of < grade 1 elevation from normal or decrease from normal with no clinical significance (NCS) for alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and bilirubin,  Laboratory value of < grade 1 from normal with no NCS for:  decreased: albumin, magnesium, total protein and phosphorous elevated: amylase, BUN, CPK and creatine and; elevated or decreased: calcium, glucose, potassium and sodium; Body mass index (BMI) between 17 and 35 kg/m2 at screening  Available for all planned visits and phone calls, and willing to complete all protocol- defined procedures and assessments (including ability and willingness to swallow multiple small enteric-coated tablets per study dose).  Gender and Reproductive Considerations  Male or female participants Female participants must provide a negative pregnancy test at screening and baseline or be at least one year post-menopausal or surgically sterile. Female participants of childbearing potential must be willing to use a reliable oral, implantable, transdermal or injectable contraceptive for 30 days prior to and until 60 days post last study drug administration. The form of contraception must be approved by the Investigator Contraception use by men should be consistent with local regulations regarding the methods of contraception for participants in clinical studies.  Informed Consent  Capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the ICF and in this protocol.  Exclusion Criteria  The participants must be excluded from participating in the study if they meet any of the following:  Medical Conditions  Presence of significant uncontrolled medical or psychiatric illness (acute or chronic) including institution of new medical/surgical treatment or significant dose alteration for uncontrolled symptoms or drug toxicity within 3 months of screening and reconfirmed at baseline Cancer, or treatment for cancer treatment, within past 3 years (excluding basal cell carcinoma or squamous cell carcinoma) Presence of immunosuppression or medical condition possibly associated with impaired immune responsiveness, including diabetes mellitus  History of irritable bowel disease or other inflammatory digestive or gastrointestinal condition that could affect the distribution/safety evaluation of an orally administered vaccine targeting the mucosa of the small intestine.  Such conditions may include but are not limited to:  Esophageal Motility Disorder Malignancy Malabsorption Pancreaticobiliary disorders Irritable bowel syndrome Inflammatory Bowel Disease Surgical Resection GERD Hiatal Hernia Peptic Ulcer (History of cholecystectomy is not exclusionary) History of any form of angioedema History of serious reactions to vaccination such as anaphylaxis, respiratory problems, hives or abdominal pain Diagnosed bleeding disorder or significant bruising or bleeding difficulties that could make blood draws problematic Any condition that resulted in the absence or removal of the spleen Acute disease within 72 hours prior to vaccination defined as the presence of a moderate or severe illness (as determined by the Investigator through medical history and physical exam). (Assessment may be repeated during screening period.) Presence of a fever ≥ 38oC measured orally at baseline (Assessment may be repeated during screening period) Any significant hospitalization within the last year which in the opinion of the investigator or sponsor could interfere with study participation.  Any of the following history or conditions that may lead to higher risk of clotting events and/or thrombocytopenia:  Family or personal history of bleeding or thrombosis History of heparin-related thrombotic events, and/or receiving heparin treatments History of autoimmune or inflammatory disease  Presence of any of the following conditions known to increase risk of thrombosis within 6 months prior to screening:  Recent surgery other than removal/biopsy of cutaneous lesions Immobility (confined to bed or wheelchair for 3 or more successive days) Head trauma with loss of consciousness or documented brain injury Receipt of anticoagulants for prophylaxis of thrombosis Recent clinically significant infection Any other condition that in the clinical judgment of the investigator would jeopardize the safety or rights of a participant taking in the study, would render the participant unable to comply with the protocol or would interfere with the evaluation of the study endpoints Diagnostic Assessments Positive human immunodeficiency virus (HIV), Hepatitis B surface antigen (HBsAg) or hepatitis C virus (HCV) tests at the screening visit Stool sample with occult blood at screening Positive urine drug screen for drugs of abuse at screening (postive test for marijuana is not exclusionary; however concurrent use of marijuana during the study Active period through Day 57 is prohibited) Positive breath or urine alcohol test at screening and baseline Prior/Concurrent Therapy Receipt of a licensed vaccine (including any COVID-19 vaccines under Emergency Use Authorization) within 14 days prior to baseline vaccination or planned administration during the study active period (Day 57) Use of antibiotics, proton pump inhibitors, H2 blockers or antacids within 7 days prior to study drug administration or planned use during the active study period (Day 57) Use of medications known to affect the immune function (e.g., systemic corticosteroids and others) within 2 weeks before study drug administration or planned use during the active study period (Day 57) Daily use of nonsteroidal anti-inflammatory drugs within 7 days prior to study drug administration or planned use during the active study period (Day 57) Administration of any investigational vaccine, drug or device within 8 weeks preceding study drug administration, or planned use within the duration of the study Other Exclusions Donation or use of blood or blood products within 30 days prior to study drug administration or planned donation during the active study period (Day 57) History of drug, alcohol or chemical abuse within 1 year of screening History of hypersensitivity or allergic reaction to any component of the investigational vaccine, including but not limited to fish gelatin