INCLUSION CRITERIA: Biopsy proven KSHV-associated MCD, confirmed in the Laboratory of Pathology, CCR Age >=18 years. ECOG performance status <=4 (Karnofsky >=20%). Ability of subject to understand and the willingness to sign a written informed consent document. Participants may be co-enrolled in other protocols, including investigational studies to treat KSHV-associated malignancies.  EXCLUSION CRITERIA:  Any condition or set of circumstances that in the opinion of the investigators would make participation in this study unsafe or otherwise inappropriate for a given individual. Pregnancy