Inclusion Criteria:  Age over six months to receive dihydroartemisinin-piperaquine Height over 90cm or weight over 15kg to receive ivermectin or placebo Willingness to adhere to trial procedures Individual written, informed consent from the participant or parent/guardian in the case of participants below the age of 18 years (and assent in young people between the ages of 12 and 17 years of age)  Exclusion Criteria:  Known severe chronic illness (AIDS, Tuberculosis, chronic malnutrition) Known hypersensitivity to either dihydroartemisinin-piperaquine or ivermectin Pregnancy (any trimester) and breastfeeding (for ivermectin (or placebo)) and pregnancy (first trimester only) (for dihydroartemisinin-piperaquine) Travel to a Loa loa endemic country (eg Central African Republic) (for ivermectin (or placebo)) Concomitant drugs that influence cardiac function or affect the corrected QT interval (for dihydroartemisinin-piperaquine)