Inclusion Criteria:  Patients with colorectal cancer with clear pathological diagnosis and Western medicine diagnostic criteria. TNM classification of stage IV disease according to National Comprehensive Cancer Network (NCCN) Guidelines. Expected survival time is over 3 months. The age of 18 years old or more. According to the efficacy evaluation criteria for solid tumors (RECIST 1.1), there are measurable lesions. Chemotherapy and/or targeted therapy are planned. Signed informed consent.  Exclusion Criteria:  History of previous or combined malignancies except non-melanoma skin cancer, cervical cancer in situ, or bladder cancer (Tis and T1) received adequate treatment in the five years prior to screening. Combined with severe heart, liver, lung and kidney disease. Patients have intestinal obstruction can't take decoction and need intravenous high-energy nutrition. Patients have malabsorption syndrome or other disease affecting gastrointestinal absorption or have active peptic ulcer disease. Any unstable condition or condition that may endanger patient safety and compliance with research, such as pregnancy, depression, manic-depressive disorder, obsessive-compulsive disorder, or schizophrenia. The expected survival time is less than 3 months. The researchers determine that they were not suitable for the study.