Inclusion Criteria:  Aged ≥ 18 years; Diagnosed with EDS/HT defined by the New York critieria; With intense fatigue defined by an FSS ≥ 4; Having given free and informed written consent; Speaking french language; Being affiliated with or benefiting from a social security scheme.  Exclusion Criteria:  with progressive parenchymal pulmonary pathology (pulmonary fibrosis, post-smoking emphysema); having an ongoing pregnancy or breastfeeding; who have already received oxygen therapy for the EDS / HT indication in the last 6 months; having a pathology that causes fatigue, which is not compensated or treated; non-exhaustive list anemia, sleep apnea syndrome, psychiatric pathologies including severe depression, organ failure (cardiac, renal, respiratory, hepatic), endocrinopathies (hypo or hyperthyroidism, diabetes), nutritional deficiencies; Subject to a measure for the protection of justice.