Inclusion Criteria:  Age > 18 Histologically or cytologically confirmed invasive cancer Bulky tumor > 7 cm, determined clinically and/or radiographically, at the time of evaluation prior to enrollment Treated indicated for palliative intent Eastern Cooperative Oncology Group (ECOG) performance status < 2 Anticipated treatment deemed safe on pre-review by PI For patients with prior Radiation Therapy (RT): Dicoms must be available for dose fusion if overlap anticipated with GRID Willing and able to provide informed consent Discussion with medical oncology or surgical specialty  Exclusion Criteria:  Age < 18 ECOG performance status 3-4 Planned for definitive, curative management For patients with prior RT that overlaps with Pro-GRID: Dicoms not available Pregnant women Tumor encasing critical structure, as defined by the treating MD.