Inclusion Criteria:  Age over 18 years old; Pathologically confirmed with sinonasal mucosal melanoma; Eligible for assessment by enhanced contrast computed tomography scan or magnetic Resonance Imaging (MRI); T4N0-1M0 according to the 8th edition American Joint Committee on Cancer (AJCC) staging system, and breaks through the natural anatomical boundaries of orbital fascia or dura mater; or 2) any Tumor stage, with retropharyngeal node metastasis. unresectable tumor after multi-disciplinary team (MDT) discussion. Eastern Cooperative Oncology Group (ECOG) score between 0 to 2; No distant metastasis; Adequate organ function; Sign the informed consent forms.  Exclusion Criteria:  There is evidence or suspicious of distant metastasis on clinical examination or imaging examination; suffered from uncontrolled concurrent diseases that may interfere with treatment; Suffered from another malignant tumor or multiple primary tumors at the same time within 5 years (excluding fully treated basal cell or squamous cell skin cancer, cervical cancer in situ, etc.); With surgical contraindications: severe cardiopulmonary disease, coagulation dysfunction, etc; With and conditions that interfere with patient compliance or safety; With severe mental or neurological diseases; Uncontrolled active infection diseases; Pregnant or breastfeeding women; Patients without personal freedom or independent civil capacity; Other situations that are not suitable.