Inclusion Criteria:  Age ≥18 years Established diagnosis of Gram-negative septic shock according to SEPSIS-3 criteria The immediate post-operative period (no more than 24 hours after surgery)  Hypotension requiring vasopressor support: the need for at least one of the vasopressors listed below at the dose listed below for at least 2 hours continuously and not more than 12 hours.  Norepinephrine> 0.05 µg/kg/min Dopamine> 10 µg/kg/min Phenylephrine> 0.4 µg/kg/min Adrenaline > 0.05 µg/kg/min Vasopressin> 0.03 units/min Vasopressin (any dose) in combination with another vasopressor listed above The patient must have received intravenous infusion therapy of at least 30 ml/kg administered within 24 hours of inclusion. The patient's condition allows therapy with the Efferon LPS device for at least 4 hours.  Exclusion Criteria:  Lack of adequate antimicrobial chemotherapy  Identifying the criteria for non-inclusion; A patient may voluntarily withdraw from a trial at any time after giving informed consent and before the trial is completed. The investigator may also withdraw a participant from the trial at any time at his or her discretion and for any of the following reasons: Reasons for a participant's withdrawal from the trial will be recorded and may include, amongst others, the following Withdrawal of consent to participate in the trial by the participant. The development of an adverse event, including a serious one; individual intolerance to the investigational product, hypersensitivity to the components of the product due to which further participation in the trial is not possible. Continued participation in the trial is not, in the researcher's opinion, in the participant's health interests. The presence of deviations from the plan which, in the opinion of the Sponsor and Investigator, require the withdrawal of the participant from the trial. A positive pregnancy test result at any time during the test. When any participant withdraws from a trial, the reason for the withdrawal should be documented.