Inclusion Criteria:  18-65 years old (including 18 and 65 years old); Chronic HBV infection confirmed by serological, etiological and clinical diagnosis (HBsAg positive for more than 6 months); HBV-DNA negative after nucleoside (acid) treatment;  Laboratory test values meet the following requirements :  Liver function : AST, ALT ≤ 3×ULN; serum total bilirubin≤2×ULN; direct bilirubin≤1.5×ULN; serum albumin≥35 g/L (blood collection is not within 2 weeks before transfusion of albumin); Hematology: white blood cell count>3.0×109/L, ANC>1.5×109/L; platelet>1×ULN; hemoglobin 120g/L. (No blood transfusion (including transfusion of red blood cells and platelets) and EPO, TPO, leukocyte-stimulating factor were required within 2 weeks before blood collection) ; Renal function: serum creatinine≤1×ULN; Thyroid function: TSH and T4 in normal range or thyroid function can be completely controlled ; Determination of serum immunoglobulin : IgM≤ULN; Coagulation function: International normalized ratio: INR≤1×ULN;  Exclusion Criteria:  Chronic HBV with unexplained portal hypertension; Subjects with liver cancer or serum AFP >1×ULN; Previously received FXR therapy;