Inclusion Criteria:  Patients who, based on the agreement of parents and/or guardians, agree to participate in the research with a signed "Informed Consent Form" Patients from 3 to 17 years of age Patients older than 6 years must not only have parental and/or guardian authorization must have the consent term Patients who have not started antineoplastic treatment Patients with ALL only with BFM protocol AML patients with BFM protocol only  Exclusion Criteria:  Responsible for patients who do not sign the free and informed consent form. Patients under three years of age and over 17 years of age Children older than six years who do not agree to the term of assent Patients who have started antineoplastic treatment Patients with syndromes and/or other systemic diseases associated with the diagnosis of lymphoid and acute myeloid leukemia Neoplasms other than lymphoid leukemia or acute myeloid