Inclusion Criteria:  Over 19 years old  evidence of coronary artery disease including asymptomatic ischemia stable angina acute coronary syndrome (unstable angina, non-ST segment elevation  myocardial infarction, ST segment elevation myocardial infarction). coronary artery diameter 2.25~3.5mm, stenosis 50% or more Those who voluntarily agreed in writing to participate in this clinical study  Exclusion Criteria:  instability or psychogenic shock within 24 hours before percutaneous coronary intervention life expectancy no longer than 1 year hypersensitivity or contraindications to the following drugs or substances: heparin, aspirin, clopidogrel patients whom researchers think unsuitable for participation in this study