Inclusion Criteria:  Age ≥ 18 years Participant has provided informed consent History of migraine (with or without aura) for ≥ 12 months before screening ≥ 4 migraine days per month on average across the 3 months prior to screening Treatment with 1 oral migraine preventive medication Participant reports to their provider intolerance or insufficient response with their current preventative treatment  Exclusion Criteria:  History of cluster headache or hemiplegic migraine headache Unable to differentiate migraine from other headaches Evidence of substance-related disorders Active chronic pain syndromes (eg, fibromyalgia and chronic pelvic pain) No therapeutic response with > 3 migraine preventive medication categories Used a prohibited medication, device, or procedure Other clinically significant disorder, condition, or disease