Inclusion Criteria:  Age 35-69 years old BMI between 25-40 kg/m2 Currently non-smoking No serious health issues Fully vaccinated for COVID-19 Normal blood chemistry profile Visceral adiposity tissue (VAT) area at L4/L5 ≥90 cm2 for men and ≥80 cm2 for women East Asian, Native Hawaiian/other Pacific Islander or white ancestry Resident of the County of Honolulu Non-drinkers / low habitual drinkers, i.e., men ≤15 drinks per week, women ≤10 drinks per week DXA VAT ≥90 cm2 for men and ≥80 cm2 for women Recruit volunteers living within a 20 miles radius of the University of Hawaii Cancer Center (UHCC) in the Honolulu area Hawaii residency For peri-menopausal women, the investigators will require that they had their last period at least 1 year before baseline)  Exclusion Criteria:  Pregnancy Contraindication to MR imaging (e.g. pacemaker, claustrophobia, metal implants) Previous surgery to remove any part of the small intestine, colon or rectum (e.g.  ileostomy or colectomy) or an amputation of a leg or arm.  For women, mastectomy or taking any anti-estrogen medications. Diagnosis of Type 1 diabetes or Type 2 diabetes and taking insulin for treatment Diagnosis of thyroid conditions under treatment with hormones or medications. For women only, taking estrogen receptor blockers: tamoxifen, Nolvadex. For men only, taking any anti-androgen medications (e.g., Eulexin (flutamide); Anandron or Nilandron (nilutamide); Casodex (bicalutamide); Proscar or Propecia (finasteride); Avodart (dutasteride); or izonsteride, turosteride. Serious health issues such as dialysis, organ transplant, celiac disease, Crohn's disease, chronic liver disease, hepatitis or kidney disease. Substantial change of weight (20 pounds/10 kilograms or more) in the past six months (i.e. gain or loss). Treatment or drug prescription in the past 6 months for chemotherapy, radiation therapy (on abdomen or pelvis), steroid hormones (Cortisone, Prednisone, Methylprednisone), weight-loss prescription drugs (Lorcaserin or Belviq, Orlistat or Xenical, Phentermine, Qsymia or Qnexa, Alli), or sleep-aid prescription medication. Study visits with collection of a fasting blood sample will not be scheduled on days when IER+MED group members are restricting their energy intake. BMI outside the range of 25-40 kg/m2 (individuals with BMI over 25 will be more likely to have elevated VAT; those with BMI over 40 won't fit MRI or DXA and would be less likely to change their lifestyle) Previous problem with fasting blood collection Cannot exercise (walk) for up to 1hr/day History of claustrophobic episode; no metal in the body (for MRI) History of amputation, breast implants/mastectomy or GI resection (for DXA, MRI) Current conditions that may affect biomarker levels: insulin-dependent diabetes, thyroid condition on long-term medication, other serious medical issues (liver diseases such as chronic hepatitis, dialysis, organ transplant) Current tobacco smoking No COVID-19 vaccination  Deferral Criteria :  Volunteers with the following conditions will be called back after the specified duration:  Following treatments in past 6 months: chemotherapy or radiation of abdomen/pelvis; corticosteroid hormones; prescription weight loss drugs; estrogen/androgen receptor blockers Substantial weight change (>20lbs) in past 6 months Antibiotic use in past 3 months MRI scan or computed tomography (CAT) scan with contrast in the past 2 weeks