Inclusion Criteria:  Age ≥18 years Received kidney replacement therapy with dialysis for more than 1 month. Hemodialysis at least 3 times a week (Kt/v) greater than 1.2 Never received an organ transplant. Life expectancy of more than 1 year Research participants or representatives are welcome to join the project by signing.  Exclusion Criteria:  History of any vaccinations in the 4 weeks prior to the study. History of receiving influenza vaccine 6 months before entering this study. History of allergy to flu vaccine or allergic to egg white Fever or headache, muscle pain (influenza-like illness) 3 days before vaccination Thrombocytopenia On immunosuppressive drug (Prednisolone 15 mg daily or equivalent for two weeks in a row in the previous 3 months) or immunocompromised patient Patient or family history of having had Guillain-Barre disease. (Guillain-Barre syndrome) The research participant or his representative refuses or requests to withdraw.