Inclusion Criteria:  Males ≥ 18 years old at the time of informed consent Ability to provide written informed consent and HIPAA authorization  Willingness to donate a fasting urine sample for research Patient Cohort  Histologically confirmed prostate or urothelial carcinoma Localized disease No neoadjuvant chemotherapy for disease Healthy Volunteer Cohort Healthy volunteers must not have prostate or urothelial carcinoma  Exclusion Criteria:  Concurrent disease or condition that would make the subject inappropriate for study participation or any serious medical or psychiatric disorder that would interfere with the subject's safety Dementia, altered mental status, or any psychiatric condition that would prohibit the understanding or rendering of informed consent