Inclusion Criteria:  Over 18 years either sex Women of childbearing age with a negative pregnancy test In close contact group or epidemiological nexus of a positive COVID-19 case Able to understand and grant informed consent Real-time - polymerase chain reaction test with a negative result  Exclusion Criteria:  Known hypersensitivity or allergy to any component of the drug under evaluation Age under 18 years Use of immunosuppressants (including systemic corticosteroids) in the last 30 days Pregnant or lactating Patients with other acute infectious diseases Patients with autoimmune disease and/or chronic decompensated diseases Who have received a vaccine for COVID-19 (1/2 dose) or that have taken ivermectin (prior to 30 days of the study) or who are participating in another COVID-19 prophylaxis study