Inclusion Criteria:  Patients' age ≥18 years Patients who had been on regular hemodialysis for at least 3 months. Patients' residual daily urine output is less than 100 mL/day. Pre study one week average systolic BP ≥120 mmHg but ≤ 180 mmHg. Patients who have achieved their dry weight as assessed by clinical examination. Predialytic serum sodium level ≥ 140mmol/l. Kt/V ≥ 1.2  Exclusion Criteria:  Patients who have advanced heart failure or permanent atrial fibrillation decompensated liver disease, neoplastic illness, overt edema. History of acute cardiovascular accidents or infections during 3 months preceding entry into the study. Patients prone to hypotension or other intradialytic adverse events. Patients participating in another interventional study that may affect blood pressure.