Inclusion Criteria:  Age 18-75 years ECOG PS 0-1 Curative surgery (R0 resection) ypStage III B and ypStage III C No distant metastasis after surgery  Exclusion Criteria:  any treatment before surgery including chemotherapy, radiotherapy and targeted agents. Previous or concurrent cancer that is distinct in primary site or histology from colon cancer within 5 years prior to randomization. Significant cardiovascular disease including unstable angina or myocardial infarction within 6 months before initiating study treatment. Heart failure grade III/IV (NYHA-classification). Unresolved toxicity higher than CTCAE v.4.0 Grade 1 attributed to any prior therapy/procedure. Subjects with known allergy to the study drugs or to any of its excipients. Current or recent (within 4 weeks prior to starting study treatment) treatment of another investigational drug or participation in another investigational study. Breast- feeding or pregnant women Lack of effective contraception