Inclusion Criteria:  1)Patients with Irregular Vaginal bleeding with endometrial thickness is greater than 5mm(Postmenopausal) or10mm (Premenopausal) via transvaginal ultrasound； 2)Able to perform curettage or other image examination and surgical pathological staging； 3) Patients with complete clinical data, pathological test and follow-up data； 4)Ability to understand, sign informed consent and agree to participate in the investigator.  Exclusion Criteria:  1)Patients without Endometrial carcinoma; 2)Women during pregnancy and lactation; 3)Those who are known to be allergic to ultrasound contrast agents; 4)Patients with arterial-venous (right to left) shunt in the heart or lung or with serious heart diseases or with serious lung diseases; 5)Any other condition makes patient not eligible for this clinical trial.