Inclusion Criteria:  Age greater than 28 days and less than 85 years Planned complex cardiac surgery with planned use of cardiopulmonary bypass  Exclusion Criteria:  Expected order for washed or volume reduced platelets Patient with known anti-platelet antibodies Platelet transfusion refractoriness due to anti-HLA antibodies Known or suspected pregnancy Previously randomized in this study Conscious objection or unwillingness to receive blood products Known IgA deficiency Known congenital platelet disorder Known congenital bleeding disorder Planned post-operative extracorporeal membrane oxygenation (ECMO), ventricular assist device (VAD), and/or continuous renal replacement therapy (CRRT)/ hemodialysis Patients intended to receive whole blood either intra-operative or post-operative for bleeding Platelet transfusion (of any type) within 24 hours prior to the date of surgery Pre-operative thrombocytopenia, defined as platelet count <75x10(9)/L, based on the most recent labs completed within 72 hours prior to the date of surgery.