Inclusion Criteria:  The patient must have been diagnosed with cancer at ≤25 years of age and have been diagnosed with one or more congenital anomalies reported through the APEC14B1 registry intake data. All types of non-syndromic birth defects and all types of cancers are eligible, regardless of patient vital status.  The patient must be enrolled on APEC14B1 with consent to future contact and registered with COG by a North American member institution. Note: (history of) treatment on a COG therapeutic trial is not required.  Language: English, French, or Spanish speaking.  The patient may participate regardless of the availability of biological parent(s).  Exclusion Criteria:  Patients with a self-reported genetic syndrome as identified in the APEC14B1 Registry are not eligible.