Inclusion Criteria:  Non-functioning patients undergoing endoscopic transsphenoidal tumor surgery under general anesthesia  Exclusion Criteria:  Patients who do not agree to participate in the study Patients with contraindication to dexmedetomidine Patients with previous history of endoscopic transsphenoidal tumor surgery Patients who take anticoagulants or have bleeding disorder Patients with conduction block or cardiovascular disease Patients with psychiatric disease such as dementia, delirium Patients have difficulty filling out the QoR-15 questionnaire Pregnant or lactating women Patients who have allergies to propofol, remifentanil, fentanyl or rocuronium Patients with myasthenia gravis or myasthenic syndrome