Inclusion Criteria:  Male or nonpregnant female aged 18 years or older with chronic open angle glaucoma or ocular hypertension in both eyes. Provide signed and dated informed consent in accordance with good clinical practice and local legislation prior to any study procedure. Be able and willing to follow study instructions and complete all required visits. Subject requires treatment of both eyes and is able to discontinue use of all ocular hypotensive medication(s) or switch ocular hypotensive medications and undergo appropriate washout period.  Exclusion Criteria:  Subjects with angle closure glaucoma Females who are pregnant, breast feeding, or planning a pregnancy. Females of childbearing potential who do not agree to utilize an adequate form of contraception. Current, or past history of, severe hepatic or renal impairment Current, or history within 2 months prior to baseline of, significant ocular disease Functionally significant visual field loss Contraindication to brinzolamide or sulfonamide therapy or known hypersensitivity to any component of brinzolamide or sulfonamide therapy Subjects currently in another clinical trial