Inclusion Criteria:  Type 1: Patients undergoing a routine clinical MR examination using established MR techniques to which an additional new sequence is added for evaluation, who give verbal consent for additional data to be acquired for evaluation of a new MR technique. Type 2: Patients who voluntarily agree to participate in the study by giving written informed consent. Type 3: Normal volunteers who voluntarily agree to participate in the study by giving written informed consent.  Exclusion Criteria:  Standard MR Exclusion criteria apply to all MR examinations, as documented in the MRI Local Rules. Patients or volunteers who are unwilling to undergo an additional MR examination, for example due to claustrophobia, will be excluded from the study. Normal volunteers who do not have an NHS number or who are not registered with a GP will be excluded.