Inclusion Criteria:  Women who meet the following inclusion criteria will be eligible to participate in the study:  Age between 20-45 years; Diagnosed with APS: patients meet the Sydney classification criteria; Diagnosed with UCTD: at least one presence of auto-antibodies, including antinuclear antibody (ANA), anti-extractable nuclear antigen (ENA) antibodies, anti-doublestranded DNA (ds-DNA) antibody, antiphospholipid antibody(aPL), and anti-cyclic citrullinated peptide (CCP) antibody, with or without at least one symptoms or signs suggesting connective tissue disease(CTD) , while not fulfilling any classification criteria of a defined CTD. Participate voluntarily in this study, willing to use medication and follow-up according to treatment plan, and sign informed consent.  Exclusion Criteria:  Women who meet any of the following criteria will be excluded from the study:  1.Any known etiology of previous pregnancy loss:  Known paternal, maternal or embryo chromosome abnormality. Maternal endocrine dysfunction: corpus luteal insufficiency; polycystic ovarian syndrome; premature ovarian failure (follicle stimulating hormone, FSH ≥20uU/L in follicular phase); hyperprolactinemia; diabetes mellitus; other hypothalamic pituitary-adrenal axis abnormality Maternal anatomical abnormality: uterine malformation; Asherman syndrome; cervical incompetence; uterine fibrosis more than 5 cm.Vaginal infection. Any known severe cardiac, hepatic, renal, hematological or endocrinal diseases:  2. Any active infection: Active infection including V aricella zostervirus(VZV), human immunodeficiency virus (HIV), Human papillomavirus (HPV),syphilis or tuberculosis.  3. Allergic to prednisone, hydroxychloroquine, low-molecular-weight heparin or aspirin.  4.Disease history as follows:  Past history of digestive ulcers or upper gastrointestinal hemorrhage. Past history of malignancy. Past history of epilepsia or psychotic disorders.  5.Women have been diagnosed with Systemic lupus erythematosus  6. Women who disagree or cannot complete pregnancy and follow-up after delivery.