Inclusion Criteria  Females or males aged 18 years and above Having undergone renal transplantation within the previous 2 years Current treatment with tacrolimus Evidence of impaired glucose tolerance (defined as a blood glucose level between 7.8-11.1 mmol/L after a two hour oral glucose tolerance test) Provision of written, informed consent prior to any study specific procedures  Exclusion Criteria  Unable to consent Planning on becoming pregnant/unwilling to use highly effective contraception during the 3-month treatment period or breastfeeding. Clinically significant history of abnormal physical and/or mental health as judged by the investigator other than conditions related to chronic kidney disease History of Type 1 or Type 2 diabetes mellitus; or on treatment with anti-diabetic medications Prior therapy with Envarsus Exposure to an investigational drug withing the preceding 3 months, or 5 half-lives whichever is greater.