Inclusion Criteria:  Subject is a male or a female aged ≥ 18 years Have given their written consent to participate in the study Use of artificial tears (AT), autologous serum or specific dry eye medications during the last 6 months prior to the selection Willing to not use AT or autologous serum for the study duration VAS scale for Dry Eye Symptom Score ≥ 40 Total CFS ≥ 5 Schirmer's test with anesthesia < 10 mm/5min Patients with Sjögren Syndrome  Exclusion Criteria:  Any concomitant treatment or prior ocular procedure or surgery, or alteration of the dose of systemic medications at the time of entry into the study Use of contact lenses during the study Significant Eye diseases according to investigator's opinion