Inclusion Criteria:  Subject >18 years of age Patients with significant acute or chronic coronary de-novo lesions or ISR lesions requiring treatment using PCI Treatment with at least one DCB (device choice at the operator's discretion) In case of a patient with lesions treated at different procedural time, lesions will be separately collected and documented Subjects must be willing to sign a patient informed consent (PIC) or must have signed the General Consent (GK).  Exclusion Criteria:  Patient is <18 years of age Patient unwilling or unable to provide informed consent pregnancy and lactation Indication for surgical revascularization