INCLUSION CRITERIA: Confirmation of peritoneal carcinomatosis from appendiceal, colorectal, ovarian, or peritoneal mesothelioma histologies by the Laboratory of Pathology, NCI. Measurable or evaluable disease as defined by RECIST v1.1. criteria and/or by peritoneal carcinomatosis index (PCI) score. Participants must be assessed to be able to undergo complete cytoreduction, with PCI score >= 30 at the time of laparoscopy. Age >= 18 years. ECOG performance status <= 1 (Karnofsky >= 80%).  Participants must have adequate organ and marrow function as defined below:  Leukocytes >= 3,000/mcL Absolute neutrophil count >= 1,000/mcL Platelets >= 75,000/mcL Total bilirubin within normal institutional limits AST (SGOT)/ ALT (SGPT) <= 3x institutional upper limit of normal (ULN) Creatinine within normal institutional limits  OR  --Creatinine clearance >= 60 mL/min/1.73 M^2 for participants with creatinine levels above institutional normal calculated using eGFR.  Because therapeutic agents used in this trial are known to be teratogenic, women of childbearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for 180 days after last study treatment; should a woman suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately. Ability of participant to understand and the willingness to sign a written informed consent document. Ability and willingness to co-enroll on the tissue collection protocol 13C0176, Tumor, Normal Tissue and Specimens from Patients Undergoing Evaluation or Surgical Resection of Solid Tumors .  EXCLUSION CRITERIA:  Participants with known extra-abdominal metastatic disease. Participants who have received intraperitoneal chemotherapy or other anti-cancer therapy within the last 4 weeks prior to the start of study treatment. Participants who have undergone major surgery within the last 12 weeks prior to the start of study treatment. History of allergic reactions attributed to platinum-containing compounds. History of dihydropyrimidine dehydrogenase deificiency (appendiceal or colorectal  cancer patients only).  Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements. Pregnant women are excluded from this study because the protocol involves major abdominal surgery and chemotherapeutic agents with the potential for teratogenic or abortifacient effects; because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother, breastfeeding should be discontinued if the mother is undergoing treatment. HIV-positive participants with detectable viral load despite antiretroviral therapy are ineligible because of participants increased risk of lethal infections when treated with marrow-suppressive therapy. HIV-positive participants who have undetectable viral load on antiretroviral therapy may be considered for this study only after consultation with a NIAID physician.