Inclusion Criteria:  Adults of both sexes, regardless of color or social class; Age over 18 years, with good clinical characteristics at medical discretion; Research patients who agree to participate in the study and sign the consent form free and informed; Chronic renal failure patients on dialysis regimen (3 times a week). Chronic Kidney Failure with indication for anticoagulant during dialysis  Exclusion Criteria:  Not agreeing with the terms described in the informed consent; Research patients with sensitivity to sadistic heparin; Research patients with hypersensitivity to benzyl alcohol; Research patients with a history of bleeding or disease that change in coagulation may worsen or terminate the clinical picture, such as ulcer gastric; Research patients with a history of peptic ulcer.