Inclusion Criteria:  Female patients Type of surgery; Modified Radical Mastectomy MRM Physical status ASA II, III. Body mass index (BMI): > 20 kg/m2 and < 35 kg/m2.  Exclusion Criteria:  Patient refusal. BMI <20 kg/m2 and >35 kg/m2 Known sensitivity or contraindication to drug used in the study (local anaesthetics, opioids). History of psychological disorders and/or chronic pain. Contraindication to regional anaesthesia e.g. local sepsis, pre- existing peripheral neuropathies and coagulopathy. Severe respiratory or cardiac disorders. Advanced liver or kidney disease. Pregnancy. Physical status ASA IV and Male patients.