Inclusion Criteria:  Agree to comply with the trial treatment plan and visit plan, voluntarily agree to sign the informed consent form; 18-75 years old (including boundary value), no gender limit; previous standard treatment failed, no standard treatment or standard treatment is not applicable at this stage; The expected survival time is at least 12 weeks  Exclusion Criteria:  Receiving other unmarketed clinical research drugs or treatments within 4 weeks before using the research drug for the first time; Brain parenchymal metastases or meningeal metastases with clinical symptoms, which are not suitable for inclusion in the group by the investigator's judgment; Women who are pregnant or breastfeeding; The investigator believes that the subject has other conditions that may affect compliance or are not suitable for participating in the study