Inclusion Criteria:  Histologically proven stage II-IV squamous HNC Indication for radiotherapy or radio-chemotherapy No history of antitumor therapies No history of oral ulcer and salivary gland diseases Normal vital signs (body temperature: 36 to 37.5∘C, heart rate: 60 to 100 beats per minute, respiratory rate: <20 per minute, and mean arterial pressure: 70 to 100mmHg), and Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2  Exclusion Criteria:  Terminal cancer for which aggressive treatments were not suitable Impaired renal or hepatic function at initial diagnosis (including chronic kidney disease stages III, IV, and V and Aspartate transaminase (AST), Alanine aminotransferase (ALT) ≥5 × the upper normal limit) Uncontrolled psychiatric problems or altered mental status Had received medications for other clinical trials