Inclusion Criteria:  Age: 18-40 Body Mass Index: 30-45 kg/m2 No regularly planned exercise/physical activity for at least 6 months Women must have regularly occurring menses and must be premenopausal  Exclusion Criteria:  Evidence/history of cardiovascular or metabolic disease Medications known to affect lipid or glucose metabolism, or inflammation Weight instability ≥ ± 6 pounds in the last 3 months Tobacco or e-cigarette users Women must not be pregnant or actively lactating