Inclusion Criteria for enrollment:  Clinical indication to undergo transoral incisionless fundoplication (TIF) with the EsophyX device for treatment of chronic gastro-esophageal reflux disease; Availability for prolonged follow-up (5 years) after TIF at San Raffaele Hospital; Signed informed consent for participation in the observational registry.  Exclusion Criteria for enrollment:  Absence of clinical indication to undergo transoral incisionless fundoplication (TIF) with the EsophyX device for treatment of chronic gastro-esophageal reflux disease; Unavailability for prolonged follow-up (5 years) after TIF at San Raffaele Hospital; No signed informed consent for participation in the observational registry.