Inclusion Criteria:  Patients developed MSA based on clinical examination and consensus MSA criteria. Patients diagnosed with MSA for less than 4 years. Patients with an anticipated survival of at least 3 years in the opinion of the examiner. Patients with MOCa and Mini Mental State Examination (MMSE) values of more than 24. For Adipose Autologous-MSC group subjects were not experiencing active infection, which was confirmed by screening for HbSAg, Anti HCV, Syphilis, HIV, CMV, Rubella, and Toxoplasma. Subjects are willing to participate in research and fill out an informed consent form. Do not have autoimmune disorder, or undergoes management disorders and / or other diseases related to MSA Subjects are willing to participate in research and fill out an informed consent form.  Exclusion Criteria:  Suffer from systemic autoimmune diseases (systemetic lupus erythomatosus, Addison's disease, Crohn's disease, arthritis management), immunodeficiency (SIDA), or blood clotting disorders or management of malignant diseases (diseases associated with MSA) Undergo immunosuppressive therapy, anticoagulants or corticosteroids. Patients with malignant neoplasms and close family history of neoplasms. already had history of spinal surgery, have paralysis or have spinal diseases. Patients with a history of electroconvulsive therapy. Patients with a history of brain surgery for Parkinson's disease. Patients with systemic or local infections located close to the injection site. Undergo immunosuppressive therapy, anticoagulants or corticosteroids. The patient was not willing to take part in the study and did not fill out informed consent.