Inclusion Criteria:  Age 18-79 at the time of planned SFA intervention SFA lesion requires intervention (according to ACC/AHA/SCAI/SIR/SVM 2018 Appropriate Use Criteria for Peripheral Artery Intervention, ABI, imaging, and/or clinical symptoms) Index SFA lesion is ≤150 mm Rutherford Classification of Peripheral Artery Disease (PAD) is Class 2, 3, 4, or 5 Minimum two vessel run-off without a hemodynamically significant lesion below the treatment lesion (in at least one vessel to the foot) in the opinion of the treating physician  Exclusion Criteria:  Study lesion is a Chronic Total Occlusion (CTO) Clinically significant (in the opinion of the treating physician) inflow disease of the aorta, common iliac, external iliac, or common femoral artery Presence of an additional hemodynamically significant stenosis within the SFA in the opinion of the treating physician Active cancer (any type) Life expectancy less than 1 year Pregnancy