Inclusion Criteria:  Clinical diagnosis of Type 2 diabetes mellitus Clinical diagnosis of Diabetic Foot Ulcer  Exclusion Criteria:  Type 1 diabetes mellitus(T1DM), special type of diabetes, gestational diabetes mellitus, drug-induced hyperglycemia TNTL allergy Chronic kidney failure（eGFR≤30ml/min/1.73cm2）, severe liver function damage (transaminase ≥ 3 times the normal value), acute or chronic pancreatitis, autoimmune disease, malignant tumors Recent acute complications of type 2 diabetes mellitus（ketoacidosis, hyperosmolar nonketotic diabetic coma, lactic acidosis etc.）or other emergency situations History of using glucocorticoids and immunosuppressants Mental illness and cognitive dysfunction or poor compliance, unable to take medication as required Malignant ulcer