Inclusion Criteria:  Clinically evident lesions as morphologically altered tissue noted at conventional visual tactile examination Clinically evident suspicious lesions which are morphologically altered tissue noted at comprehensive visual ductile examination ( CVTE) with a definitive diagnosis of a potentially malignant disorders (PMD) or even a malignant disorder to be a distinct possibly. Healthy subjects presenting no clinically detectable oral lesions matched for age, gender, and risk factors will recruited as controls.  Exclusion Criteria:  .<18 years of age.  pregnant or breast feeding. .psychiatrically or mentally unstable.