Inclusion Criteria:  first ever non traumatic supratentorial primary intracerebral haemorrhage on non contrast CT brain admitted within 24 hours of symptom onset  Exclusion Criteria:  blood diseases, decompansated hepatic or renal impairment, or encephalopathy caused by electrolyte disturbance on anticoagulant treatment if devolped major complications during hospitalization ( e.g sever chest infection, hypoxia, or deep venous thrombosis ) comorbid neurological or psychiatric disorders