Inclusion Criteria:  At timepoint of inclusion in the LIFE-Heart study normal left ventricular ejection fraction (≥ 50%) At timepoint of inclusion in the LIFE-Heart study normal NT-proBNP (< 125 ng/l)  Exclusion Criteria:  At timepoint of inclusion in the LIFE-Heart study acute coronary syndrom  Troponine elevation above 14 pg/ml as well as coronary intervention, or isolated troponine elevation above 50 pg/ml in the absence of a coronary intervention No troponine elevation but coronary intervention Creatine kinase > 0.41 µmol/l*s and Creatine kinase to Creatine kinase-MB ration >6% or Creatine kinase-MB > 0.82 µmol/l*s At timepoint of inclusion in the LIFE-Heart study missing data on left ventricular ejection fraction At timepoint of inclusion in the LIFE-Heart study missing NT-proBNP measurement At timepoint of inclusion in the LIFE-Heart study missing data on echocardiographic diastolic function and structural alterations of the left ventricle At timepoint of inclusion in the LIFE-Heart study relevant valvular heart disease (including relevant aortic stenosis, mitral- and/or tricuspid regurgitation, congenital heart disease, mitral stenosis)