Inclusion Criteria:  ASAⅠ~Ⅲ Over 18 years old Patients undergoing General Anesthesia surgery requiring BIS Monitoring Obtained informed consent  Exclusion Criteria:  Patients who have mental disorders and unable to answer Patients who have taken anti-epileptic drugs and psychotropic drugs for a long time Patients who are pregnant Patients who refuse to participate in this trial Patients considered by the investigator to be unsuitable for inclusion in the trial