Inclusion Criteria:  The age of subjects are between 18-90 years old (including 18 and 90 years old); All kinds of tumor diseases of subjects are acceptable; All kinds of PD-1 immune checkpoint blockades or dosages are acceptable; The subjects knew about the experiment and signed the informed consent voluntarily; The subjects plan to receive PD-1 immune checkpoint blockades and potentially to be treated for over 3 months; The subjects complicated with atherosclerotic carotid plaques.  Exclusion Criteria:  Subjects stop receiving or changing the PD-1 immune checkpoint blockades during follow-up; Subjects are reluctant to continue to be involved in this study; Known pregnant and lactating women; The parameters (e.g., CCA intima-media, ICA intima-media or carotid plaque burden) could not be calculated because of the quality of ultrasound image; Other situations that the researchers judged were not suitable for inclusion.