Inclusion Criteria:  HIV negative person, who was assigned male or female at birth, who reports sex with another man in the last year and is in good general health Aged 18-59 years Not currently taking PrEP and no plans to initiate during study Not currently taking PEP Not currently taking doxycycline or other tetracycline-derived antibiotics and no plans to initiate during the study Willing to use condoms consistently for the duration of the study Able to provide informed consent in English No plans for relocation in the next 4 months Willing to undergo peripheral blood, urine, rectal or vaginal secretion collection, and a rectal or vaginal and cervical biopsy procedure Willing to use study products as directed Hepatitis B surface antigen (HBsAg) negative (screening lab test) Creatinine clearance >60 ml/min  Exclusion Criteria:  Currently infected with hepatitis virus and/ or has liver disease Current or chronic history of kidney disease or creatinine clearance (CrCl)<60 ml/min  Continued need for, or use during the 90 days prior to enrollment, of the following medications:  Systemic immunomodulatory agents Supraphysiologic doses of steroids (short course steroids less than 7 days duration, allowable at the discretion of the investigators) Chemotherapy or radiation for treatment of malignancy Experimental medications, vaccines, or biologicals Intent to use HIV antiretroviral pre/post-exposure prophylaxis (PrEP or PEP) during the study, outside of the study procedures Intent to use doxycycline or other tetracycline-derived antibiotics during the course of the study, outside of the study procedures Any other clinical condition or prior therapy that, in the opinion of the investigator, would make the patient unsuitable for the study or unable to comply with the study requirements Not pregnant and no plans on getting pregnant throughout the duration of the study Known allergic reaction to study drugs