Inclusion Criteria:  Healthy female and male adult volunteers German speaking, or good knowledge of the German language Able to understand the study Able to give informed consent  Exclusion criteria:  Regularly taking medication potentially interfering with pain sensation (analgesics, antihistamines and calcium and potassium channel blockers) Current pregnancy Daily smokers (as per WHO definition: A daily smoker is someone who smokes any tobacco product at least once a day.) Neuropathy Chronic pain Neuromuscular or psychiatric disease Known or suspected heart, kidney or liver disease Hypertension (Systolic (mmHg) >130, Diastolic (mmHg) >80) History of fainting or seizures History of Frostbite Current medications (psychoactive medication, narcotics, intake of analgesics) or being currently in psychological or psychiatric treatment.