Inclusion Criteria:  Hospitalized adults over 18 years of age Positive molecular test for SARS-CoV-2 Computed tomography (TC scan) compatible with "COVID pneumonia" and / or in need of supplemental oxygen Therapy with Tenofovir-DF (TDF) or Hydroxychloroquine (HCQ) at least 3 days Signed informed consent  Exclusion Criteria:  Negative molecular test for SARS-CoV-2 No need for hospitalization Negative CT scan for "COVID pneumonia" and / or no supplemental oxygen requirement for COVID-19 Had not received either HCQ or TDF, or both drugs at the same time, or had received HCQ or TDF for two days or less No signed informed consent