Inclusion Criteria:  Pathologically confirmed angioimmunoblastic T-cell lymphoma according World Health Organization (WHO) classification; Age≥18years; ECOG≤2; Patients received at least one systemic treatment previously and achieved no remission or relapsed after first-line treatment; Adequate bone marrow hematopoietic function: ANC>1.5 × 109/L，HGB>90g/L，PLT>80 × 109/L; Adequate organ function: ALT≤3 times ULN, TBil≤1.5 times ULN, SCr≥50ml/min/m2, cardiac function grade 0-2 (NYHA);  Exclusion Criteria:  Active or uncontrolled infections requiring systemic treatment within 14 days before enrollment; Any instability of systemic disease, including but not limited to severe cardiac, liver, kidney, or metabolic disease need therapy; Pregnant or lactating women;