Inclusion Criteria:  Having serum levels of LDL cholesterol (LDL-C) at least 100 mg/dL and being treated with any group of statins for at least 3 months prior to the trial.  Exclusion Criteria:  Having very high serum levels of LDL-C (above 200 mg/dL) Hypersensitivity to orlistat Using other lipid-lowering agents with statins History of liver disease Pregnancy.