Inclusion Criteria:  Age ≥18 years; Clinical diagnosis meets the diagnostic criteria of the national HFRS prevention and treatment plan (Hantavirus-specific IgM antibody is positive). The classification and staging standards of HFRS patients are based on the "Expert Consensus of Shaanxi Province on Diagnosis and Treatment of Hemorrhagic Fever with Renal Syndrome".  Exclusion Criteria:  Age <18 years; Have a history of kidney disease; Have a history of liver disease; Have a history of malignant tumor; Receive dialysis treatment before admission; Combined with hypertension, coronary heart disease and diabetes history; Combined with HIV infection and patients with autoimmune diseases and pregnancy.