Inclusion Criteria:  Admitted to an intensive care unit (ICU) with pathogen associated shock defined as:  The need for vasopressors to maintain mean arterial pressure (MAP) ≥ 65 mmHg despite adequate fluid resuscitation Presence of a pathogen detected in the bloodstream within 72 hours of screening using commercially available in-vitro diagnostic testing Male or non-pregnant female adult. At least 18 years of age at time of enrollment. Within 72 hours of admission to the ICU.  Exclusion Criteria:  Pregnant or breast feeding. Anticipated transfer to another hospital (that is not a study site) within 72 hours for any reason. Not anticipated to survive more than 24 hours. Allergy to heparin sodium. Patients who cannot tolerate placement of double-lumen catheter. High risk of bleeding (platelet count <50mm3 or International normalized ratio >1.5). Inability to tolerate extra-corporeal therapy (defined as MAP<65 despite fluids and vasopressors). Advanced cancer (defined as stage IV). Unable to obtain informed consent from either patient or legally authorized representative. Hypotension and volume depletion due to etiologies other than sepsis. Neutropenia with an absolute neutrophil count <500mm3.