Inclusion Criteria:  Age ≥ 18 years old. The clinical symptoms and signs are consistent with acute anterior circulation large vessel occlusion; NIHSS score ≥ 10 points; (Level of consciousness) NIHSS score 0 or 1; The time from onset to randomization is within 6 hours of onset; The mRS score before stroke is 0-1; The patient has good compliance and can complete the operation with local anesthesia; The patient can cooperate with this study and follow-up in the future Patient and family members sign informed consent。-  Exclusion Criteria:  Rapid neurological function improvement, NIHSS score less than 10 points, or evidence of vessel recanalization prior to randomization; Seizures at stroke onset; Intracranial hemorrhage; Symptoms suggestive of subarachnoid hemorrhage, even if CT scan was normal; Platelet count of less than 100,000 per cubic millimeter; Severe hepatic or renal dysfunction; Active and chronic obstructive pulmonary disease or acute respiratory distress syndrome; >3 L/min oxygen required to maintain peripheral arterial oxygen saturation (SaO2) 95% as per current stroke management guidelines; Medically unstable; Life expectancy<90 days; Evidence of intracranial tumor;