Inclusion Criteria:  Subjects suffering from systemic sclerosis with at least an ulcerative lesion on the fingers of the upper limbs; The ulcer must not present bone or tendon exposure; Chronicity of the lesion: at least 4 weeks; Men and women aged ≥ 18 years; The patient must be able to understand the purposes of the clinical trial and provide informed consent in writing.  Exclusion Criteria:  Patients who are participating in other clinical trials with drug or medical device; Patients with a history of self-harm who can voluntarily alter the course of healing; Women who are pregnant or breastfeeding1; Patients who participated in a clinical study on the healing of skin ulcers during the previous month; Patients who are unable to understand the purposes and objectives of the study; Presence of infectious signs according to IDSA criteria at the time of recruitment; Presence of peripheral vascular obstructive diseases; Patients with psychiatric disorders; Patients with neoplasia; Patients with pathologies that induce skin photosensitivity; Patients with a limited life expectancy.