Inclusion Criteria:  Meet the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) 2010 Classification Criteria for Rheumatoid Arthritis Disease activity score (DAS28) >= 3.2 Age >= 18 Stable RA therapy for 12 weeks prior to baseline Power Doppler Score >= 5 (for the PDUS 34 joint score) Must use at least one highly effective method of contraception Written informed consent  Exclusion Criteria:  Prior exposure to cannabis <= 28 days prior to baseline Current diagnosed substance use disorders (including Alcohol Use Disorder) Moderate (Child-Pugh B) or severe (Child-Pugh C) hepatic impairment Chronic infections >10mg of prednisone daily use Daily use of central nervous system (CNS) depressant medications (e.g. sedatives, hypnotics [zolpidem, temazepam, alprazolam, lorazepam, diphenhydramine etc.]) Women who are pregnant, planning to become pregnant, or breast feeding Sexually active subjects and their partners who are of childbearing potential (ie, neither surgically sterile nor postmenopausal) and not agreeing to use adequate contraception Deemed unsafe by the investigator History of an allergic reaction or adverse reaction to cannabis is exclusionary.