Inclusion Criteria:  Over 18 years old Cardiovascular surgery patients with cardiopulmonary bypass Preoperative EuroSCORE I≥6（European System for Cardiac Operative Risk Evaluation) Obtained informed consent  Exclusion Criteria:  Patients who cannot accept blood products Patients who refuse to accept transfusion Patients with autologous blood reserve before surgery Patients who are going to receive heart transplantation or have undergone heart transplantation Patients who have undergone ventricular assist device implantation surgery Patients who refuse to participate in this trial