Inclusion Criteria:  Pathological proven diagnosis of cervical cancer or benign gynecologic tumor and will undergoing panhysterectomy or pathological proven diagnosis of cervical cancer and will undergoing radiotherapy Tumor accessible for biopsy during the course of radiotherapy or tumor samples could be obtained via surgery Patient must provide study-specific informed consent prior to study entry  Exclusion Criteria:  History of autoimmune diseases History of immunotherapy History of pelvic radiotherapy Will receive immunotherapy during the course of treatment Contraindications for biopsy, such as high bleeding risk