Inclusion Criteria:  Multiple myeloma patients who are diagnosed by bone marrow morphology and immunology Patients with stable condition after conventional treatment Patients with renal insufficiency or abnormal M protein Patients over 18 years of age Liver function: blood bilirubin ≤ 35μmol/L, enzymes aspartate transaminase (AST)/aka alanine aminotransferase (ALT) is less than 2 times the upper limit of normal Normal heart function Physical condition score 0-2 level (ECOG score) Obtain an informed consent form signed by the patient or family member  Exclusion Criteria:  Allergies or obvious contraindications to any of the drugs involved in the plan Severe heart disease, including myocardial infarction and cardiac insufficiency. Suffering from other organ malignancies Active tuberculosis patients and HIV-positive patients At the same time suffering from other blood system diseases Pregnant or lactating women Able to understand or follow the research plan Past history of intolerance or allergy to similar drugs Patients under 18 years of age Participating in other clinical researchers at the same time There are any other circumstances that hinder the progress of the research