Inclusion Criteria:  Male or female, age > 18 years old, Patient undergoing a simple tooth extraction or multiple tooth extraction on the same quadrant, Patient taking curative or preventive antithrombotic treatment or patient with a moderate thrombocytopenia, Patient reachable after surgery, Signed informed consent form, Subject affiliated to a health insurance system, or is a beneficiary.  Exclusion Criteria:  Known allergy to bovine collagen, Preoperative INR<1.5 or >3 or instable, Patient with high risk of bleeding, history of postoperative hemorrhagic complication, Treatment with bone resorption inhibitor, or patient irradiated at the cervico-facial level, Contraindication to anesthesia using articaine with 1:200,000 epinephrine, Clinical follow-up expected to be difficult, Presence of uncontrolled hypertension, uncompensated diabetes or other clinically relevant systemic alterations, Current participation in another clinical trial or subject still within the exclusion period of a previous clinical trial, Vulnerable subjects.