Inclusion Criteria:  The pregnant women and newborns who were injected with the new crown vaccine during the perinatal period of both husband and wife or one of them were the observation group, and the pregnant women and newborns who were not vaccinated with the new crown vaccine during the perinatal period of both husband and wife were the control group. They were fully informed of the risk, voluntarily joined the study and signed the informed consent.  Exclusion Criteria:  Both husband and wife or family have previously delivered congenital abnormal fetus; Neither husband nor wife was willing to participate in this study.