Inclusion Criteria:  Boys aged between 3 and 18 years (inclusive) diagnosed with C-CALD (elevated levels of VLCFA and leukodystrophy at brain MRI) Boys or girls aged between 15 months and 12 years (inclusive) diagnosed with LI-MLD (onset <30 months, low ARSA activity and accumulation of sulfatides in urine) Adult males diagnosed with AMN (elevated VLCFA and clinical symptoms of AMN without leukodystrophy at brain MRI) Children (15 months-18 years) without significant neurologic disease Informed consent obtained: from the parents or guardian for children patients and children controls; from subject himself for adult patients.  Exclusion Criteria:  Participation to a therapeutic clinical trial Treatment likely to modify the immune system Unable to have a blood collection (i.e. low hemoglobin level at the investigator's judgment) Any other reason, to the discretion of the investigator Children or adults without health insurance or social security