Inclusion Criteria:  The indications for endoscopic resection were large (≥20mm in diameter), nonpedunculated, benign, and early malignant mucosal or submucosal gastric or colorectal lesions. Written informed consent  Exclusion Criteria:  The tumor has spread to the muscularis layer, lymph nodes, or distal metastases; Multiple lesions (≥20mm in diameter) ; Underlying bleeding disorder; The platelet count less than 50×10^9/L; Serious cardio-pulmonary, hepatic or renal disease; Intolerance to endoscopy; Other high-risk conditions or disease (such as massive ascites, etc.); Pregnancy.