Inclusion Criteria:  45-65 years old, BMI 30-49.99 kg/m2 At elevated risk for CRC based on the following criteria: In the past 5 years, 3 or more adenomatous polyps or an adenomatous polyp >1 cm, a well-accepted definition of increased risk Are up to date with CRC screening. Prediabetic (fasting glucose 100-125mg/dl)  Exclusion Criteria:  Have a history of renal disease, autoimmune disorders, immunodeficiency, malabsorptive disorder, significant gastrointestinal and hepatic disease, surgical change in gastrointestinal anatomy, severe ischemic heart disease, severe pulmonary disease, severe mental health disorder, eating disorder, or bariatric surgery; Abuse alcohol (> 50 grams/day), illicit drugs (other than self-reported marijuana use), or use combustible tobacco; Have controlled type 2 diabetes or undiagnosed uncontrolled diabetes based on hemoglobin A1c (HbA1c) > 9.0%; Have a history of cancer treatment within the past 12 months, CRC, genetic predisposition to CRC (e.g., Lynch syndrome); Have a baseline body weight > 450 lbs (weight limitation of the DXA); Are on a weight loss diet or actively involved in a formal weight loss program (e.g., Weight Watchers); Are not weight stable for 3 months prior to the study (weight gain or loss > 4 kg); Are unable to keep a food diary for 7 consecutive days during screening; Are night shift workers; Are pregnant or trying to get pregnant; Are taking drugs that influence study outcomes (weight loss medications); Are perimenopausal or have an irregular menstrual cycle (menses that does not appear every 27-32 days). Are non-English speaking Are taking anticoagulant medications or medications with endoscopic risk Are taking antivirals or immunosuppressant medications