Inclusion Criteria:  Subjects agree to participate in the study and having dated and signed the informed consent form; Subjects who have the capability to communicate, to make themselves understood, and to comply with the study's requirements; Male or female aged ≥ 18 years and ≤ 70 years old; Subjects free from cardiovascular diseases (CVDs) (primary prevention for CVDs); Subjects with sub-optimal serum levels of cholesterol (total cholesterol (TC) of 200-240 mg/dl OR LDL-C of 130-190 mg/dl); Subjects with body mass index (BMI) 25 -34.9 Kg/m2  Exclusion Criteria:  Subjects already affected by CVDs (secondary prevention for CVDs); Subjects with serum levels of triglycerides (TG)> 400 mg/dl; Type 1 or type 2 diabetes; Lipid-lowering treatment not stabilized since at least 2 months; Known current gastrointestinal diseases and use of medications for their treatment; Known clinically relevant decline in renal function; Women in fertile age not using consolidated contraceptive methods Pregnancy and Breastfeeding; History or clinical evidence of any significant concomitant disease that could compromise the safety of the subject or the possibility of completing the study; Any medical or surgical condition that would limit the patient adhesion to the study protocol