Inclusion Criteria:  adult patients (aged 18 years or order) patients with suspected or new diagnosed fibrotic disease (supporting evidence may include , BBI, MRI, CT and pathology report) patients who had scheduled 68Ga-FAPI-04 PET/CT scan patients who were able to provide informed consent (signed by participant, parent or legal representative) and assent according to the guidelines of the Clinical Research Ethics Committee  Exclusion Criteria:  patients with pregnancy the inability or unwillingness of the research participant, parent or legal representative to provide written informed consent