Inclusion Criteria:  Meet the diagnostic criteria for primary immune thrombocytopenia To show a platelet count < 30 * 10^9/L, or with bleeding manifestations, or both Willing and able to sign written informed consent Meet the diagnostic criteria of refractory ITP according to Chinese guidelines  Exclusion Criteria:  Secondary thrombocytopenia severe immune-deficiency or history of primary immunodeficiency active or previous malignancy HIV virus infection, tuberculosis, or other active infection (sepsis, pneumonia, or abscess) pregnancy or lactation diabetes hypertension cardiovascular diseases severe liver or kidney function impairment psychosis osteoporosis inflammatory bowel disease or gastric disease arterial or venous thromboembolism within the 6 months before screening or patients who required anticoagulant treatment an organ or haematopoietic stem-cell transplantation neutrophil count of less than 1500 cells per mm³; glycosylated haemoglobin less than 8%; partial thromboplastin time 1∙5 times or less the upper limit of normal (ULN) clinical electrocardiogram changes neoplastic disease within the past 5 years corrected QT interval greater than 450 ms for men and greater than 470 ms for women; substance misuse within the previous 12 months; and those who could not adhere to the protocol or were planning to have a surgical procedure in 6 months.