Inclusion criteria:  Major subjects (≥18 years old) Couples who have been treated at the HUS for a preimplantation diagnosis request for type 1 neurofibromatosis (confirmed by a molecular molecular analysis) and who have benefited from preliminary analyzes, between 01/01/2004 and 30/06 / 2021 Couple who, after receiving information, did not express their opposition to the reuse of their data for the purposes of this research  Exclusion criteria:  Couples who expressed their opposition to participating in the study Subject under guardianship, curatorship or safeguard of justice