Inclusion Criteria:  Informed Consent as documented by signature Patient undergoing video-assisted thoracoscopic anatomical resection of the lung under general anaesthesia for confirmed or anticipated Stage I lung cancer (UICC 8th edition) American Society of Anesthesiologists (ASA) physical status classes I to III  Exclusion Criteria:  NRS while coughing > 0 Previous ipsilateral thoracotomy or sternotomy Abdominal or contralateral thoracic surgery up to 6 months preoperatively Contraindications to the class of drugs under study, e.g. known hypersensitivity or allergy to class of drugs or the investigational product Contraindications to self-administration of opioids Women who are pregnant or breast feeding Chronic steroid therapy (e.g. Prednisone > 10mg/day for more than last 2 weeks before surgery) Chronic, daily pain therapy Congestive heart failure Liver insufficiency Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant, Participation in another study with investigational drug within the 30 days preceding and during the present study, Enrolment of the investigator, his/her family members, employees and other dependent person