Inclusion Criteria:  ECOG PS 0-2; histological diagnosed diffuse large B cell lymphoma; normal hematological, hepatal, renal function; normal heart function with LVEF ≥ 50%;  Exclusion Criteria:  Diagnosed as a malignant tumor other than lymphoma or receiving treatment, except for the following conditions:  ①Have received treatment for the purpose of curing, and no malignant tumor with known active disease occurred ≥5 years before enrollment;  ②Skin basal cell carcinoma (except melanoma) that has received adequate treatment and has no signs of disease;  ③ Carcinoma in situ of the cervix that has received adequate treatment and has no signs of disease.  Heart disease with clinical significance, including unstable angina pectoris, acute myocardial infarction within 6 months before screening. Congestive heart failure (NYHA) heart function is graded in grade III or IV (Annex 3) Severe arrhythmia requiring treatment. Patients with active hepatitis B and HIV infection. Women who are pregnant or breastfeeding Patients who have received organ transplants in the past Patients with severe active infection Have a history of severe neurological or psychiatric diseases, including dementia or epilepsy