Inclusion Criteria:  Diagnosis of Systemic Sclerosis according to American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR) 2013 criteria Systemic Sclerosis patients with moderate to sever skin sclerosis  Exclusion Criteria:  Patients witg a disease considered inappropriate for participation in clinical trials, such as serious cardiac / hepatic / renal / pulmonary / hematologic disease Patients with a diseases that could interfere with assessment of Systemic Scleorosis Patients with body weight less than 30.0kg Pregnant or lactating women.