Inclusion Criteria:  Patients diagnosed clinically with small vessel disease and verified by MRI. must be at age of 50 or more.  Exclusion Criteria:  large vessel disease or non-ischemic leukoencephalopathy. Patients with any type of cerebral haemorrhage . Diabetic patients . concurrent retinal diseases as epiretinal memberane and macular degeneration. Past history of retinal operation or ocular surgery except for cataract surgery. An history of glaucoma or optic neuropathy. hematological diseases and coagulopathies.