Inclusion Criteria:  Closed craniocerebral trauma; The injury time on admission was less than 10 hours; The GCS score was less than 9, and the GCS score was evaluated without sedation or using muscle relaxants; They were 18-75 years old; Authorized close relatives to sign informed consent.  Exclusion Criteria:  The damage time is uncertain; Penetrating brain injury; With spinal cord injury; Severe and fatal injuries associated with other parts of the body; Pregnant women or pregnancy test positive; Lactating women had lactation needs during the study period; blood suger is lower than 2.8 mmol / L; Renal insufficiency, history of dialysis treatment, or serum creatinine more than 2.5 mg / dl; The total bilirubin was more than 1.5 times of the upper limit; INR was greater than 1.4; Systolic blood pressure was less than 90 and had no response to fluid resuscitation; Allergic to sulfonylureas; There was a history of admission for brain injury, mental or neurological diseases within 3 years before brain injury; The drug use was restricted due to emergency operation within 8 hours after brain injury; There was a history of taking antiplatelet drugs, oral anticoagulants or heparin or low molecular weight heparin 72 hours before brain injury; There was a history of taking sulfonylureas within 30 days before brain injury; 17. There was a history of participating in other drug trials within 30 days before brain injury;  18. There was a history of G6PD deficiency; 19. There were clinical conditions that other researchers did not consider to meet the inclusion criteria.