Inclusion Criteria:  Female, at least 18 years old Welfare scale 0, 1, and 2 (ECOG - WHO) Patients with stage IV breast cancer who have histopathological data according to the TNM Classification of Malignant Tumors (TNM) from American Joint Committee on Cancer (AJCC) 8th edition 2017 Patients who are willing to participate in the test and sign an informed consent Patients who undergo breast cancer chemotherapy with luminal B sub-type or triple negative with anthracycline base Patients who are willing and able to fill out a questionnaire The patients who are willing and able to comply with the test protocols during the test  Exclusion Criteria:  Unable to meet the test protocol Patients with liver and kidney disorders Patients with other diseases/disorders that are meaningful according to the investigators will be excluded from the test Patients with cancer that has metastasized to the brain Pregnant women and breastfeeding mothers Patients with the ejection fraction smaller-than or equal to 55%