Inclusion Criteria:  Adequate oral hygiene (That is brush teeth daily and exhibit no signs or oral neglect) A minimum of 20 gradable teeth including 4 molars with scorable facial and lingual surfaces. Teeth that are grossly carious, extensively restored, orthodontically banded, abutments, exhibiting severe generalized cervical and/or enamel abrasion, teeth with veneers, or third molars will not be included in the tooth count A mean gingival index greater than or equal to (>=) 1.95 per the Modified Gingival Index at Baseline (for those in the randomized treatment group) A mean gingival index less than or equals to (<=) 0.75 per the Modified Gingival Index at Baseline (for those in the healthy reference group) A mean plaque index >= 1.95 per the 6 site Turesky modification of the Quigley-Hein Plaque Index at Baseline (for those in randomized treatment groups) Greater than or equal to 10 percent (%) bleeding sites at baseline (for those in randomized treatment groups)  Exclusion Criteria:  History of significant adverse effects, including sensitivities or suspected allergies, following use of oral hygiene products such as toothpastes, mouth rinses and red food dye Dental prophylaxis within four weeks prior to Screening/Baseline 1 visit More than three sites that have periodontal pockets depths measuring 5mm or greater in depth Teeth having periodontal pocket depths measuring more than 3 mm in depth (healthy reference group) History of medical conditions requiring prophylactic antibiotic coverage prior to invasive dental procedures Use of Antibiotics, anti-inflammatory or anticoagulant therapy, phenytoin sodium or diphenylhydantoin, calcium channel blockers, cyclosporin A, immunostimulants/ immunomodulators during the study or within the one month prior to the Baseline 1 exam. Intermittent use of certain anti-inflammatory medication is acceptable at the discretion of the Investigator