Inclusion Criteria:  Patients with either:  Histologically confirmed invasive carcinoma or multiple myeloma OR Clinical diagnosis of carcinoma or multiple myeloma OR Suspected clinical diagnosis of multiple myeloma  Patients with one of following tumor types and age ranges:  Breast cancer diagnosis at ages 18-45 Colon cancer diagnosis at ages 18-55 Kidney cancer at diagnosis at ages 18-50 (American Indian or Alaska Native [AIAN] and non-Hispanic Whites [NHW] only) Liver cancer diagnosis at ages 18-55 Prostate cancer diagnosis at ages 18-55 Multiple myeloma diagnosis at ages 18-50  Patients whose tumor specimen was collected or will be collected during one of the following routine procedures:  Surgery to remove cancer OR Routine biopsy procedures performed to confirm a histologic diagnosis OR Routine biopsy procedure performed to obtain additional tumor material for routine prognostic or predictive biomarkers OR Routine procedure to place a vascular access device prior for systemic therapy Patients who have received no therapy for their cancer other than surgery, irrespective of stage  Collection of specimens from living patients:  Ability to understand and willingness to sign a written informed consent document indicating their willingness to have their tissue or biologic fluid specimens used for research as outlined in this protocol  Collection of specimens from deceased patients:  Banked tissue samples and/or banked biologic fluid specimens of deceased patients may be used as long as all samples or specimens are properly de- identified prior to submission Sites must use the Central Institutional Review Board for the National Cancer Institute (NCI CIRB).  Exclusion Criteria:  Patients who do not meet criteria for an early onset malignancy Prior systemic therapy or radiation therapy for their malignancy Tumor does not meet quality metrics Patient refused consent for use of tissue for research activities included in the Early Onset Malignancies Initiative A diagnosis of a synchronous invasive malignancy Patients with a history of invasive cancer or hematologic malignancy in preceding 5 years