Inclusion Criteria:  Trisomy 21 by genetic karyotype. Down syndrome children with delayed milestone. Definite identification of Down syndrome by neurologist. Children having the average birth weight above 2.500 grams and average birth length above 49.52 cm. Laxity, low muscle tone and psychomotor development deficits  Exclusion Criteria:  Infants with Heart Defect. Seizure. Critical orthopedic difficulties or deformities (hip instability, patellar instability, foot deformity). Unrestrained thyroid conflicts. Perilabour asphyxia (Apgar of minutes 1 and 5 equal to or less than 7). Critical optical or acoustic disorders. Mass below the 3rd percentage of Down syndrome