Inclusion Criteria:  18 years ≤Subject ≤ 75 years, Male and/or female; Clinical confirmation of COVID-19 patients in accordance with novel Coronavirus Diagnosis and Treatment Protocol (Trial Version 8) of the NHC Participants must be able to understand and willing to participate in this research, this study and signed informed consent form (if incapacitated subjects, the researchers believe the subjects to the test in its own interests, should be signed by its legal guardian informed consent, or telephone inform consent (recording) and note it in the original medical records and other relevant documents)  Exclusion Criteria:  Subjects with any unstable conditions, a history of significant hypersensitivity, or known allergy to components of the investigational agent; SARS-CoV-2 infection by PCR ≥ 96h; Platelet (PLT) < 50×10^9/L, or hemoglobin (HGB) < 60g/L; Total bilirubin (TBIL) > 2×ULN (upper limit of normal value), or alanine transferase (ALT), aspartate transferase (AST), alkaline phosphatase (ALP) > 5×ULN; glomerular filtration rate (GFR) < 30mL/min·1.73m^2, or serum creatinine increased by 0.5mg/ dL within 7 days, or oliguria (<400mL/24hr), or anuria (<100mL/24hr); Pregnant or breast feeding; Persons who have family planning or do not agree to use effective non-drug contraceptive measures within 6 months after signing the ICF; Subjects participating in another clinical study. There will be a need for washout with 5 half lives depending on the study treatment or 30 days since any previous study, whichever is longer; he inestigators concluded that the patients had other reasons for not being eligible for the study.