Inclusion Criteria:  Persons> 35 years of age who are capable of giving informed consent Planned diagnostic colonoscopy (clarification of symptoms, polyp follow-up) Screening colonoscopy for men >50 or women > 55 years of age  Exclusion Criteria:  Colon bleeding Colon carcinoma Known polyps for removal Inflammatory bowel disease Colonic stenosis Other suspected colon disease for further clarification Follow-up care after colon cancer surgery (partial colon resection) Anticoagulant drugs that make a biopsy or polypectomy impossible Poor general condition (ASA IV) Incomplete colonoscopy planned