Inclusion Criteria:  Patients with primary invasive breast cancer cT1-T3 cN0-2 Full tumour biology available before initiation of NACT Oral and written consent Age ≥ 18 years Able to travel to the exercise testing and training premises Anticipates being able to adhere to the exercise program requirements  Exclusion Criteria:  Pregnancy or breast-feeding Inability to absorb or understand the meaning of the study The presence of musculoskeletal, neurological, respiratory, metabolic or cardiovascular conditions that may prevent safe completion of the exercise demands of the study Currently performing equal to or more than 150 mins of moderate to high intensity aerobic exercise and 2 sessions per week of moderate intensity resistance exercise