Inclusion Criteria:  Diagnosed with cancer of different aetiologies Undergoing chemotherapy or targeted therapy (TKIs) Diagnosed with HFS-HFSR grade 1, 2 or 3 (National Cancer Institute - Common Terminology Criteria for Adverse Events, NCI-CTCAE v5) Age ≥ 18 years Able to comply to the study protocol Able to sign written informed consent  Exclusion Criteria:  Pre-existing skin rash, ulceration or open wound in the treatment area (hand, foot) Known allergy to polyurethane Substance abuse patients or patients with medical, psychological or social conditions that may interfere with the patient's participation in the study or evaluation of the study results as judged by the investigator Any condition that is unstable or could affect the safety of the patient and their compliance in the study as judged by the investigator