Inclusion Criteria:  Age is over 18 years old Histologically or cytologically diagnosed patients with recurrent or refractory B-cell malignancies ECOG performance status (PS) 0 ~ 1 Expected survival of > or = 3 months  Exclusion Criteria:  The use of PI3Ks as the target of anti-tumor drugs progress (due to intolerance group) Received any other anti-cancer treatment within 4 weeks Unable to swallow, chronic diarrhea and intestinal obstruction, there are many factors that affect drug use and absorption Allergy, or known to have a history of allergy to the drug components