Inclusion Criteria:  Unilateral involvement; Signs and symptoms of degenerative pathology of knee cartilage; Radiographic and MRI signs of degenerative pathology of the knee cartilage (Kellgren-Lawrence 1-4 grades); Failure, defined as the persistence of symptoms, after at least one course of conservative treatment (pharmacological, physiotherapeutic or infiltrative treatment); Ability and consent of patients to actively participate in clinical follow-up;  Exclusion Criteria:  Patients who have undergone intra-articular injections of another substance in the previous 6 months; Patients undergoing knee surgery within the previous 12 months; Patients with malignant neoplasms; Patients with rheumatic diseases; Patients with diabetes; Patients with hematologic diseases (coagulopathies); Patients on anticoagulant therapy; Patients with metabolic disorders of the thyroid gland; Patients abusing alcoholic beverages, drugs or medications; Body Mass Index > 35; Pregnant or lactating women. Patients with established hypersensitivity to bovine collagen or vitamin C. Patients with joint or peri-articular infections, emarto, erythema, or psoriatic patches in the knee joint area