Inclusion Criteria:  Males or females ≥18 years of age, Not less than 6 months on HD, High level of serum dephosphorylated uc-MGP Signed informed consent,  Exclusion Criteria:  Patients with normal level of dp-ucMGP History of thrombosis, Intake of vitamin K antagonists (warfarin) at baseline or in the 3 months prior to baseline, Inflammatory bowel disease, Liver dysfunction,