Inclusion Criteria:  Over 18 years of age ECOG performance status of 0,1, or 2  Newly discovered lung nodule with:  At least one solid lung nodule measuring 6 mm- 20 mm in greatest diameter detected on screening CT No single lesion larger than 20 mm in greatest diameter when multiple nodules present High- or intermediate-risk nodules per American College of Chest Physician (ACCP) guidelines Able to provide informed consent  Exclusion Criteria:  Prior cancer of any type for the previous 3 years Prior organ, bone marrow, of hematopoietic stem cell transplant Contraindication to administration of [18F]FDG Inability to undergo a PET/CT scan Ongoing infection, either acute or subacute Severe COPD or lung disease requiring home oxygen use Pregnancy