Inclusion Criteria:  Men indicated for prostate biopsy due to elevated PSA and/or abnormal DRE No history of prior prostate biopsy No history of genitourinary cancer, including prostate cancer 18 years or older No contraindications to biopsy No contraindications to mpMRI  Exclusion Criteria:  History of prior prostate biopsy History of genitourinary cancer, including prostate cancer Contraindications to biopsy Contraindications to mpMRI