Inclusion Criteria:  Patients with anterior ischemic stroke due to large vessel occlusion. A previous autonomous modified Rankin Scale (mRS) of less than 2. A National Institutes of Health Stroke Scale (NIHSS)≥4 A groin puncture within 4.5 hours of the neurological deficit onset.  Exclusion Criteria:  Imaging documentation of intracranial haemorrhage A premorbid mRS score of 2 or more Absence of diffusion perfusion mismatch in CT perfusion.