Inclusion Criteria:  All patients with Chronic limb threatening ischemia present with one or more of the following:  Rest pain (Rutherford category 4) Minor tissue loss (Rutherford category 5) admitted to the department of Vascular surgery for Endovascular Intervention with provided written informed consent.  Exclusion Criteria:  Patients presented with proved vasculitis. Patients with Chronic liver disease if there is prolonged PT. Patients with Heart failure if the patient is orthopneic and cannot lay on table for long time). Patients with impaired renal function.