Inclusion Criteria:  Persons able to read and understand Italian. people affected by COPD stage C (GOLD 3 o 4, and/or 2 or more exacerbations per year or 1 or more hospitalizations for exacerbations and score of COPD assessment test-CAT < 10 or mMRC 0-1). People affected by COPD stage D (GOLD 3 o 4, and/or 2 or more exacerbations per year or 1 or more hospitalizations for exacerbations and score of COPD assessment test-CAT ≥ 10 or mMRC ≥ 2).  Exclusion Criteria:  Persons or dyads not able to guarantee the presence on the MBSR intervention sessions for the four months requested. Persons with diagnosis of anxiety or depression. Persons that have practiced before or actually practice yoga or mindfulness. Persons with cognitive impairment. Persons under continuous oxygen therapy. Persons with diagnosis of cancer or other terminal diseases or any psychiatric problem.