Inclusion Criteria:  Solitary pulmonary nodule with indication of bronchoscopic diagnostic approach Age between 18 and 90 years Written informed consent after participant's information  Exclusion Criteria:  Age < 18 and > 90 years Lacking ability to form an informed consent (including impaired judgement, communi-cation barriers) Contraindication against bronchoscopy (e.g. co-morbidities) INR > 2 or Thrombocytes < 50000 Double antiplatelet drugs (e.g. ASS and Clopidogrel) within 7 days before biopsy Anticoagulation with NOAK within 48 hours before biopsy Moderate or severe pulmonary hypertension (mPAP > 30 mmHg, RV/RA >30 mmHg) Tumors suspicious of endobronchial growth