Inclusion Criteria:  Adult males and females, 18+ years in general good health as assessed by the investigator.  Clinical laboratory results within the following ranges:  granulocytes ≥2,000/mm3 platelets >50,000/mm3 serum creatinine ≤2X the upper limit of normal (ULN) Aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), alkaline phosphatase ≤3X the ULN. Subject must have no other "clinically significant" abnormal findings in his/her medical history, physical examination or clinical laboratory test results as assessed by the investigator. Subject must be willing to adhere to the instructions of the investigator and his or her research team. Subject must sign an Informed Consent Form prior to any study specific procedures and entry into the study. BCC (subtype: superficial or nodular) confirmed histologically by diagnostic shave biopsy at the Screening Visit. If previously confirmed, subjects can only have diagnosed BCC via shaved biopsy within 6 months of first study treatment. Biopsy removed ≤25% of the original volume of the target lesion. Primary BCC (i.e., no previous treatment) Lesion size ≥ 64 mm2 or 8 x 8 mm and ≤ 169 mm2 or 13 x 13 mm, i.e., the entire lesion must be covered by 13X13 mm area of the array containing the microneedles Subjects must avoid sunlight/ultraviolet light to the target lesion for the duration of the study.  Female subjects must be:  postmenopausal (no menstrual period for a minimum of 12 months), or surgically sterile upon entry into the study. female subjects of childbearing potential must have a negative pregnancy test upon entry into this study and agree to use a highly effective method of contraception from Screening until the final follow-up visit. Consult Section 5.5 in this protocol for a description of effective contraceptive methods. Female subjects must also have negative pregnancy tests before each dose is applied to female subjects Male subjects with female partners of child bearing potential must be either surgically sterile or agree to use a double-barrier contraception method (i.e., condom + diaphragm, condom or diaphragm + spermicidal gel or foam) from screening until the final follow-up visit.  Exclusion Criteria:  Evidence of clinically significant, unstable medical conditions as assessed by the investigator. Previously demonstrated sensitivity to doxorubicin or carboxymethyl cellulose. Female subjects who are pregnant or breastfeeding. The subject has uncontrolled, significant intercurrent or recent illness. Concomitant anticoagulation with coumarin agents (e.g., warfarin), direct thrombin inhibitors (e.g. dabigatran), betrixaban, or platelet inhibitors (eg, clopidogrel). Prophylactic use of Low-dose aspirin for cardio-protection (per local applicable guidelines) and low-dose low molecular weight heparins (LMWH) are permitted. Topical therapy(ies) to the target lesion within 6 weeks of first treatment. Prior excisional surgery performed on the lesion to be treated in this study. Recent therapy(ies) to the BCC treatment area. Recurrent BCC (previously treated) at the site presented for treatment. BCC lesion to be treated is located in an area where excisional biopsy is undesired or aesthetically unacceptable to the subject Subject with other active malignancies except for non-metastatic prostate cancer, carcinoma in situ of the skin or cervix, and basal cell cancer in locations other than lesion of interest. Subject with evidence of metastatic malignancies. Concomitant disease requiring systemic immunosuppressive treatment. Genetic skin cancer disorder, e.g., basal cell nevus syndrome. Subject is currently participating or has participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to the first dose of study treatment (patients who are in a follow-up phase of an investigational study may participate as long as it has been 30 days after the last dose of the previous investigational agent). Evidence of dermatological disease or confounding skin condition within 3 mm margin of the target BCC lesion, e.g., SCC, actinic keratosis, rosacea, psoriasis, atopic dermatitis, eczema. Existing condition or treatment within 3 months prior to the Screening Visit that may have impact on clinical outcome for the treatment of BCC or delay in wound healing from the standard of care excision.