Inclusion Criteria:  -Age group between 35 to 42 years old AFC <5 AMH <1.2 ng/ml first IVF trial  Exclusion Criteria:  - Serious and unstable disease, such as cerebrovascular, liver, and kidney disease "will be unfit for pregnancy". History of malignant or border line tumors "will be unfit for pregnancy". Endocrine or metabolic disorder "affecting quality of oocyte so affecting results". Either one of the couple with chromosomal abnormalities "affecting quality of oocyte so affecting results". Male partner with severe oligoasthenozoospermia or with teratozoospermia"affecting quality of embryo to be transfered so affecting results". Any contraindications to growth hormone, pregnancy (to be ruled out and documented before GH treatment). female patients with causes of infertility other than poor ovarian reserve females suffering from congenital or acquired uterine anomalies "will affect results of implantation and pregnancy rates " females with focal uterine lesions anomalies "will affect results of implantation and pregnancy rates " BMI >30 kg/m2 "affecting quality of oocyte so affecting results".