Inclusion Criteria:  Adults: Age more than or equal to 18; an equal number of Males and Females Consent to the collection of genetic material Willing to adhere to the study protocol  Exclusion Criteria:  Age <18, at screening. BMI >45 kg/m2. Blood pressure more than 140/90 mmHg. Participants who are taking more than 2 hypertension medications. History of diabetes or fasting plasma glucose >126 mg/dl or HbA1C>=6.5% or prior treatment with antidiabetic medication. Have any past or present history of cardiovascular diseases (stroke, seizure, myocardial infarction, heart failure, transient ischemic attack, angina, or cardiac arrhythmia) Women who are pregnant or breastfeeding or who can become pregnant and not practicing an acceptable method of birth control during the study (including abstinence); Estimated GFR < 60 ml/min/1.73 m2; albumin creatinine ratio ≥30 mg/g Hepatic Transaminase (AST and ALT) levels >3x the upper limit of normal Anemia (men, Hct < 38%; women, Hct <36%) Inability to exercise on a treadmill