Inclusion Criteria:  Age ≥ 18 years old Patients diagnosed with de novo mature B-ALL, Burkitt lymphoma (BL). Under physician's criteria, patients with unclassified B-lymphoma with intermediate characteristics between DLBCL and BL could be included. Candidate to intensive treatment.  Exclusion Criteria:  Other ALL subtype different from mature B-ALL/BL Severe complications not due to mature B-ALL/BL (eg, sepsis, pneumonia, shock or hemorrhage) at diagnosis. Renal failure not due to mature B-ALL /BL Heart or liver failure Severe lung disease Secondary mature B-ALL/BL Hypersensitivity to foreign proteins Previous treatment with cytotoxic drugs Pregnancy/breastfeeding Severe psychiatric disease Lack of social or familiar support