Inclusion Criteria:  female with no racial or ethnic restrictions; 18 to 75 years old; Have a bunionectomy or toe fusion surgery scheduled; must be able to read, understand, and sign consent form; generally healthy.  Exclusion Criteria:  Chronic neurologic conditions, e.g., Parkinson's pregnancy; opioids use 60 mg/day oral morphine milligram equivalent.; use of anticoagulants (low dose ASA allowed); history of gastric ulcer; renal insufficiency or congestive heart failure, contraindication to study medication as determined by surgeon Any medical condition that in the investigator's judgment may prevent the individual from completing the study or put the individual at undue risk In the judgment of the investigator, unable or unwilling to follow protocol and instructions; Diagnosis of psychological diseases, such as major depression; bipolar disorder.