Inclusion Criteria:  Patients with blepharospasm who received botulinum toxin injection therapy All patients must have had the symptoms of blepharospasm for over six months  Exclusion Criteria:  Glaucoma Age-related macular degeneration Visual acuity of 20/200 or worse Chronic obstructive pulmonary disease Cardio cerebral diseases, psychosis Loss of limb Connective tissue diseases Dialysis dependence Anyone who was unable to cooperate with the examinations