Inclusion Criteria:  age 18-70 years; diagnosis of SARS-COV-2 NCI confirmed by laboratory tests; the lung lesion volume on CT scan is significant or subtotal - CT 3-4; initiation of infusion therapy on the 1st day after patient admission to ICU  Exclusion Criteria:  1) presence of initial indications for transfer to invasive ALV at the time of screening; 2) history of Reamberin intolerance; 3) administration of other polyelectrolyte solutions with reserve alkalinity carriers; 4) pregnancy and postpartum; 5) severe renal failure requiring renal replacement therapy; 6) severe hepatic failure (Child-Pugh class C or higher); 7) diabetes mellitus; 8) terminal stage of other chronic incurable diseases