Inclusion Criteria:  Male or female 18 to 65 years old Scheduled to undergo surgery to repair open tibial fracture Willing and able to comply with all study procedures and be available for the duration of the study Provide signed and dated informed consent or obtain consent from legally authorized representative Not be pregnant, planning to become pregnant, or nursing female subjects.  Exclusion Criteria:  Unable to provide signed and dated informed consent or unable to obtain consent from a legally authorized representative Unable or unwilling to comply with all study-related procedures Known history of allergic reaction to any of the study products or its components, including any products used for standard of care (such as dressings or any coverings) Subject has known history of contraindications to general anesthesia Subject with any underlying condition or state that, in the investigator's opinion, will make them too critically ill to complete 30 and/or 90 day follow ups Pregnant, planning to become pregnant, or nursing female subjects. Any subject positive for Covid-19 virus at time of surgical screening Any open fracture, including tibial plateau or pilon fractures or any fracture that will require vascular surgery to salvage the limb, or surgery that requires referral to another surgical service (i.e., Plastics) will be excluded from this study Any patient who will require ongoing use of NPWT after hospital discharge will be excluded from the study. Subjects have evidence of prolonged QT segment, per EKG. Subjects from a vulnerable population, in accordance with 45 CFR 46 Subparts B, C, and D