Inclusion Criteria:  Must be able to provide an archived tumor sample Must have histologically or cytologically confirmed metastatic or locally advanced solid tumor Must be refractory to or become intolerant of existing therapy(ies) known to provide clinical benefit for their condition Must have at least 1 measurable lesion per RECIST v1.1 Must have adequate organ functions  Exclusion Criteria:  Has CNS metastases or carcinomatous meningitis, except if CNS metastases treated and no evidence of radiographic progression or hemorrhage for at least 28 days Active infection requiring systemic treatment within 7 days Active HBV, HCV, or HIV Any severe and/or uncontrolled medical conditions LVEF ≤50% assessed by ECHO or MUGA QTcF interval >470 msec Experiencing unresolved CTCAE 5.0 Grade >1 toxicities