Inclusion criteria:  Current major depressive episode assessed by clinician administered MINI; Minimum score of 8 on OASIS anxiety scale; Normal or corrected to normal vision/hearing, as protocol elements may not be valid otherwise; Fluent English speaker, capable of providing written informed consent  Exclusion criteria:  Has uncontrolled, clinically significant neurologic (including seizure disorders): cardiovascular, pulmonary, hepatic, renal, metabolic, gastrointestinal, urologic, immunologic, endocrine disease, or psychiatric disorder, or other abnormality, which may impact the ability of the participant to participate or potentially confound the study results; History of moderate or severe traumatic brain injury, as assessed by a TBI questionnaire; Family history of psychotic or bipolar disorder, because of low risk of inducing a manic episode with tDCS; Current diagnosis of eating disorder or obsessive-compulsive disorder; Current use of medications with major effects on brain function or the fMRI hemodynamic response (e.g., methylphenidate, acetazolamide, excessive caffeine intake > 1000 mg/day) following an initial list compiled by the Aupperle lab at LIBR but also assessed on a case by case basis); Moderate to severe current substance use disorder, defined as 5 or more symptoms of the criteria for Substance Use Disorder according to DSM 5; Drug or alcohol intoxication (based on positive UTOX or breathalyzer test at screen or baseline) or reported alcohol/drug withdrawal; Has a risk of suicide according to the Investigator's clinical judgement or per Columbia-Suicide Severity Rating Scale (C-SSRS), the subject scores "yes" on items 4 or 5 in the Suicidal Ideation section with referent to a 30-day period prior to Screening/Baseline or the subject has had one or more suicidal attempts with reference to a 2-year period prior to Screening/Baseline; MRI or tDCS contraindications; Is pregnant or lactating or intending to become pregnant before, during, or within 12 weeks after participating in this study; or intending to donate ova during this time-period. ; History of highly irritable skin and/or contact dermatitis that affects skin integrity of the scalp; Any participant judged by the Investigator to be inappropriate for the study.