Inclusion Criteria:  Female Age 18 years or older Patients undergoing elective breast conservation surgery for the treatment of Stage 0-III invasive ductal and/or ductal carcinoma in situ May include subjects treated with neo-adjuvant therapy (endocrine and/or chemotherapeutic), but not required for study inclusion Ability to understand and the willingness to sign a written informed consent document  Exclusion Criteria:  Male Metastatic cancer (Stage IV) Lobular carcinoma as primary diagnosis Previous ipsilateral breast surgery for benign or malignant disease (this includes implants and breast augmentation) Subjects with multi-centric disease (histologically diagnosed cancer in two different quadrants of the breast), unless resected in a single specimen Subjects with bilateral disease (diagnosed cancer in both breasts) Participating in any other investigational margin assessment study which can influence collection of valid data under this study Use of cryo-assisted localization Currently lactating Current pregnancy Subjects undergoing breast conserving surgery whose resected specimen will be evaluated with intraoperative pathology, frozen section, or imprint cytology