Inclusion Criteria:  ART-naïve or ART-experienced HIV-infected children between 4 weeks and <6 years of age Active TB diagnosis Weight of at least 3 kilograms Consent of the parent or legal guardian  Exclusion Criteria:  Baseline labs with evidence of ≥grade 3 abnormalities: ALT, total bilirubin, absolute neutrophil count (ANC), platelets, or creatinine Suspected TB meningitis or presenting with acute respiratory distress or decompensation Receipt of a medication that has drug-drug interactions with dolutegravir or rifampicin