Inclusion Criteria:  Volunteer subjects over 18 years old Having signed a free and informed consent Having a diagnostic of caracterised depressive episod recurrent or isolated according to DSM IV criteria (A.P.A 1994). Having an antidepressant treatment not modified since 3 weeks Score to MADRS scale ≥ 21 Subject affiliated to a social security regimen  Exclusion Criteria:  Depression with psychotic caracteristics Co-morbid diagnosis according to axis I (DSM IV) of schizophrenia, dependence (or abuse) on alcohol and / or another substance (lifetime) Patient who has already undergone seismotherapy for current episode and non-responder to this treatment Patient hospitalized under duress or under legal protection (guardianship, curatorship) Patient with a high risk of suicide (item 10 of MADRS > 4) in the absence of hospitalization. Contra-indication for IRM exam or rTMS : personnal history of comitial crisis, of neurological or neurochirurgical pathologies, metallic prosthetic material or foreign body (pacemaker, intraoculare ferromagnetic material, implanted cardiac defibrillator, cochlear implant, metal clip Pregnancy Simultaneous participation to another interventionnal study