Inclusion Criteria:  diagnosis of systemic AL amyloidosis; treatment-naïve (pre-treatment data collected at participating center available for retrospective part); age ≥18 years; ability to understand and willingness to sign an informed consent (patients who already sign informed consent for clinical data to be used in retrospective analyses will be accepted); planned (or ongoing) follow-up at participating center.  Exclusion Criteria:  non-AL amyloidosis; previous treatment for AL amyloidosis.