Inclusion Criteria:  PART I : ESCALATION, EXPANSION, RE-ENTRY COHORTS:  Histologically confirmed, locally-advanced, or metastatic pancreatic ductal adenocarcinoma (PDAC) or other malignancies known to express CA19-9 positive malignancies  PART II: PRE-SURGERY COHORT ONLY:  Biopsy-proven or high suspicion on imaging for pancreatic ductal adenocarcinoma (PDAC) (Stage T2 and T3) and Patient scheduled to undergo surgery as standard of care for their pancreatic adenocarcinoma OR Patients with Intraductal papillary mucinous neoplasm (IPMN) scheduled to undergo surgery as standard of care.  The suspicion for pancreatic carcinoma and decision for surgery will be based on review of imaging and clinical findings in the disease management team discussion including surgeon and radiologist.  PART I and II:  Signed, informed consent Age 18 or more years At least one lesion by CT or MRI ≥ 2 cm, unless determine otherwise for pre-surgery cohort subjects  CA19-9 serum level:  For Part I: >ULN or CA19-9 positive biopsy (optional); For Part II ( presurgical cohort): CA19-9 serum level (normal or high levels are allowed) or CA19-9 positive biopsy (optional) ECOG performance status of 0 to 2  Adequate laboratory parameters including:  Absolute neutrophil count (ANC) ≥1.5 x 10^9/L Hemoglobin ≥ 9.0 g/dL (in the absence of red blood cell transfusions in the prior 14 days) Platelet count >75,000/ mm^3 AST/SGOT, ALT/SGPT ≤2.5 x ULN, unless liver metastases are clearly present, then ≤5.0 x ULN Total bilirubin ≤1.5x the upper limit of normal unless considered due to Gilbert's syndrome in which case, ≤3x the upper limit of normal Creatinine (serum or plasma) ≤ 1.5 x ULN or eGFR>50 mL/min  PART I: ESCALATION, EXPANSION, RE-ENTRY COHORTS:  Willingness to participate in collection of pharmacokinetic samples  Exclusion Criteria:  Active, uncontrolled bacterial, viral, or fungal infection(s) requiring systemic therapy Major surgery other than diagnostic surgery within 4 weeks of Study Day 1 History of anaphylactic reaction to human, or humanized, antibody Other on-going cancer therapy or investigational agents (except MVT-5873) Known history of HIV Pregnant or currently breast-feeding Psychiatric illness/social situations that would interfere with compliance with study requirements Prior entry onto this protocol 3 or more times (e.g., subjects may enter this protocol and be imaged up to 3 times)