Inclusion Criteria:  Aged between 18 and 85 years; GGO is diagnosed by lung CT and failure to subside after 3 months (the patient having been re-examined by thin-section CT); The maximum diameter of the GGO is bigger than 8mm and smaller than 3cm; For single GGO: obvious progress was observed in pure GGO or the solid component of mixed ground glass nodules was more than or equal to 2 mm The patients were unable to tolerate the operation for various reasons or multiple grinding glass nodules, operation can not be completely removed; or patients had received surgery in ipsilateral chest The patient is able to understand and comply with the study and has provided written informed consent  Exclusion Criteria:  Patients who participated in any drug and / or medical device clinical trials within one month before the trial had severe disease conditions allergy to narcotic drugs had other autoimmune disease dementia or cognitive impairment can't cooperate with researchers any local treatment other than ablation was received within 4 weeks before the study