Inclusion Criteria:  female, aged from 18 to 65 years old; according to the patient's blood routine, serum ferritin and other indexes as well as clinical manifestations and signs, it was clearly diagnosed as iron deficiency anemia. all patients were diagnosed with uterine leiomyoma and / or adenomyosis by B-ultrasound, and gonadotropin-releasing hormone agonist (GnRH-a), levonorgestrel intrauterine delivery system (LNG-IUS, Manyuele), compound oral contraceptive (COC) and mifepristone could be used to interfere with menstruation. willing to sign informed consent.  Exclusion Criteria:  patients with other types of anemia: such as hereditary anemia, immune anemia, large cell anemia, microvascular anemia, renal anemia, hypofunction of endocrine glands (such as pituitary, thyroid), infectious anemia, etc.; patients who use intravenous, intramuscular injection and other oral drugs to supplement iron at the same time; patients with malignant tumors. severe cardiopulmonary disease (NYHA cardiac function IV or respiratory failure); obvious renal function impairment (serum creatinine ≥ 2mg/dL or glomerular filtration rate GFR < 40mL/min); liver insufficiency (liver function: total bilirubin > ULN, aspartate aminotransferase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) ≥ 2.0 × ULN). patients with immune function, sepsis and serious diseases of endocrine system; drug addicts or alcoholics; 9) people who have participated in other drug trials within 3 months; 10) researchers think it is not suitable for participants.