Inclusion Criteria:  Subject provides written informed consent prior to entering the study or undergoing any study procedures; Subject is a generally healthy male or female 18 to 65 years of age; Subject is considered to be healthy on the basis of medical history, physical examination, vital signs, normal electrocardiogram (ECG) and clinical laboratory test results.  Exclusion Criteria:  Subject is pregnant or lactating, or females planning a pregnancy during the course of the trial; Subject has severe cardiac, renal or hepatic impairment; Subject has used any topical drugs at the patch application site within 72 hours prior to dosing.