Inclusion Criteria:  ≥18 years of age at the time of screening Cancer patients that will receive chemotherapy with anthracyclines.  Exclusion Criteria:  Inability to adequate asses left ventricular function Previous history of heart failure Previous history of any cardiomyopathy (eg.: valve disease, Chagas' disease, infiltrative cardiomyopathy) LVEF < 50% Previous history of myocardial revascularization Permanent tachyarrhythmia (flutter, atrial fibrillation, atrial tachycardia) Contra-indication to the use of beta-blockers. Trastuzumab indication Pregnant or Breast-feeding females. On kidney replacement therapy ECOG >= 4 or Karnofsky <=30 Advanced hepatic failure (C score Child-Pugh and MELD > 15); Previous use of anthracycline Have any serious concomitant systemic disease, condition, or disorder that, in the opinion of the investigator, should preclude participation in this study Are concurrently enrolled in any other type of medical research judged not to be scientifically or medically compatible with this study