Inclusion Criteria:  renal transplant patient followed at the University Hospital of Amiens and transplanted for over a year patient treated with a calcineurin inhibitor patient having a blood test for evaluation of calcineurin inhibitor concentrations by the toxicology pharmacology laboratory of the Amiens-Picardie University Hospital, patient affiliated with social security.  Exclusion Criteria:  patient in phase of acute rejection of the graft, patient having opposed his participation, patient under guardianship or curatorship or deprived of public right