Inclusion Criteria:  Participants aged≥18 Pathological mCRPC cases confirmed by histopathological report. Evidence of a previous methastatic primary PC Availability to provide medical history data(demographic information and history of cancer). Availability to provide blood and/or tissue sample in case it is available Participants who are able to sign the informed consent form(ICF).  Exclusion Criteria:  Diagnosis of any severe acute or chronic medical or psychiatric conditions that may increase the risk associated with study participation or may interfere with the interpretation of the study results Inability of participant to provide informed consent.