Key Inclusion Criteria:  Moderate AS, defined as follows by transthoracic echo (TTE) at rest:  Max aortic velocity ≥ 3.0 m/sec and < 4.0 m/sec, and Mean aortic gradient ≥ 20.0 mmHg and < 40.0 mmHg, and AVA >1.0 cm2 and < 1.5 cm2  NYHA class ≥ II and symptoms of AS, including but not limited to:  Dyspnea at rest or on exertion Fatigue Angina Syncope in the absence of another identifiable cause LVEF > 20% by 2-D echo  Any of the following  HF event or hospitalization within 1 calendar year prior to qualifying echo NT proBNP ≥ 600 pg/ml (or BNP 80 pg/ml) measured within 6 months prior to or within 2 weeks after qualifying echo, Global longitudinal strain ≤15% (absolute value) at qualifying echo, or E/e' (average of medial and lateral velocities) ≥ 14.0 at qualifying echo  Key Exclusion Criteria:  Age < 65 years Class I indication for cardiac surgery Sievers Type 0 or Type 2 bicuspid aortic valve or Sievers Type 1 bicuspid aortic valve with ascending aorta diameter > 4.5 cm Not anatomically suitable for transfemoral TAVR In need of and suitable for coronary revascularization per Heart Valve Team Documented history of cardiac amyloidosis