Inclusion Criteria:  The patient is diagnosed with later stage of Alzheimer Disease with sever cognitive disability. All current anti-Alzheimer medicines cannot prevent disease progression and the patient's mental and physical ability persistently declined Patient's legal guardian and caregiver must voluntarily sign an approved written consent form after ample explanation of the proposed therapy.  Exclusion Criteria:  Current diagnosis of malignancy Renal/liver dysfunction: Exceed two times as normal subject Pregnant or nursing Received other trial drugs within 30 days after participation of this study Experienced major surgery or trauma in the last 14 days