Inclusion Criteria:  age 18-70 . histologically proved urinary bladder squamous cell carcinoma. non-metastatic disease. all patients who underwent radical treatment or bladder preserving approach. patient with isolated urinary bladder carcinoma (no other or previous primary).  Exclusion Criteria:  age < 18 , > 70. patient not documented having bladder squamous cell carcinoma by biopsy (cystoscopic or operative). metastatic disease. patient with synchronous or metachronous double primary