Inclusion Criteria:  Infants with a diagnosis of infantile colic per Rome IV criteria and reported to cry/fuss for ≥ 3 hours/day, within a 24-hour period as determined by the 24-hour cry/fuss eDiary AND 24 hours of LENA vocalizations Infants with a gestational period of ≥ 37 to 42 weeks Infants between 14 and ≤ 42 days of life at the completion of screening/baseline tasks Infants exclusively breastfed for at least 7 days immediately prior to enrollment and with mother's intent to continue feeding breast milk exclusively for the duration of the study Mothers willing to use their own electronic device(s) to download and utilize all required study software (decentralized trial platform on a mobile device and the LENA device software on a Windows 10 or higher laptop or desktop that has at least 10 GB of free space and fast, reliable internet) Mother is fluent in English  Exclusion Criteria:  Infants born in multiple birth (i.e., twins, triplets, etc.) Infants born with medical complications (i.e., neurological, cerebral palsy, confirmed food allergies) Infants with current evidence of failure to thrive, fever, or illness Infants with any GI tract abnormalities Antibiotic, infant formula, solid food or iron supplement intake within 7 days prior to enrollment or mother's intent to feed non-study probiotics, prebiotics, infant formula, solid food or iron supplements to their infant at any time during the study Infants who have consumed any probiotics since birth Unwillingness to discontinue/avoid products used to treat IC (i.e., Simethicone, gripe water, colic drops, etc.) during the study. Note: consumption of IC products prior to the baseline period is NOT exclusionary Maternal use of probiotics containing B. infantis during pregnancy, after the baby's birth and/or intent to use probiotics containing B. infantis at any time throughout the study Maternal smoking or smoking within the home by any household member currently or during pregnancy Mother following exclusionary diet due to her infant's colic (i.e., dairy elimination diet) Any infant the Investigator deems to be ineligible for participation