Inclusion Criteria:  Older than 18 years of age; Type 2 diabetes mellitus; EGFR ≥30 to <90 ml/min/1.73 m2; Urinary albumin creatinine ratio (UACR) ≥ 30 mg/g;  Exclusion Criteria:  Women who are already pregnant or planning to become pregnant; SBP >180mmHg and/or DBP >110mmHg; UACR ≥ 3000 mg/g Other non-diabetic renal diseases (such as polycystic kidney disease, lupus nephritis, ANCA-associated vasculitis, etc.); NYHA cardiac function grade III or above Those who have a history of cancer or are currently suffering from cancer; Receiving immunosuppressant, cytotoxic or other immunosuppressive therapy in the first 6 months; Patients with acute coronary syndrome, acute cardiac insufficiency or severe cerebrovascular disease in the previous month; Patients refused to comply with the requirements of the study to complete the study; In the investigator's judgment, the patient is unable to complete the study or comply with the requirements of the study (for management reasons or other reasons);