Inclusion Criteria:  Black male or female, of Sub-Saharan African origin (defined as participants whose parents are both black and are of Sub-Saharan African origin) aged ≥18 years to ≤45 years at the date of signing informed consent. This inclusion criterion will only be assessed at the screening visit  Healthy as defined by:  the absence of clinically significant illness and surgery within four weeks prior to dosing. Participants vomiting within 24 hours pre-dose will be carefully evaluated for upcoming illness/disease. Inclusion pre-dosing is at the discretion of the Investigator the absence of clinically significant history of neurological, endocrine, cardiovascular, respiratory, haematological, immunological, psychiatric, gastrointestinal, renal, hepatic and metabolic disease  Participants must agree to use the following contraceptive requirements for the applicable duration:  Female participants of non-childbearing potential (WNCBP): Defined as either postmenopausal (evidence of menopause based on a combination of amenorrhea for at least one year and increased serum follicle-stimulating hormone (FSH) level [>30 IU/L]), or surgical sterilisation (evidence of hysterectomy and/or bilateral oophorectomy) CONTRACEPTION REQUIRED: None Female participants of childbearing potential (WOCBP) who anticipate being sexually active with a male during the trial (from one complete menstrual cycle prior to the first IMP administration until 13 weeks after the last IMP administration):  CONTRACEPTION REQUIRED: Highly effective contraception must start one complete menstrual cycle prior to the first day of dosing and continue until 13 weeks after the last IMP administration. Highly effective contraception methods for WOCBP include:  combined (i.e. oestrogen- and progestogen-containing) hormonal contraception associated with inhibition of ovulation:  oral intravaginal transdermal  progestogen-only hormonal contraception associated with inhibition of ovulation:  oral injectable implantable intrauterine hormone-releasing system (IUS) intrauterine device (IUD) bilateral tubal occlusion infertile male partner (e.g. vasectomised, permanently sterile following bilateral orchidectomy, or any other documented cause of infertility) Female participants of childbearing potential (WOCBP) who agree to remain abstinent for the duration of the trial (from one complete menstrual cycle prior to the first IMP administration until 13 weeks after the last IMP administration):  CONTRACEPTION REQUIRED: Abstinence (sexual abstinence is considered a highly effective method only if defined as refraining from heterosexual intercourse during the entire period of risk associated with the trial treatments. The reliability of sexual abstinence needs to be evaluated in relation to the duration of the clinical trial and the preferred and usual lifestyle of the participant. Calendar, symptothermal and post-ovulation methods of contraception are not considered to be equivalent to abstinence)  • Male participants, who agree to remain abstinent for the duration of the trial (from first IMP administration until 13 weeks after the last IMP administration): CONTRACEPTION REQUIRED: Abstinence (sexual abstinence is considered a highly effective method only if defined as refraining from heterosexual intercourse during the entire period of risk associated with the trial treatments. The reliability of sexual abstinence needs to be evaluated in relation to the duration of the clinical trial and the preferred and usual lifestyle of the participant) If the situation changes post-dose during the trial, participants must use a condom with or without spermicide.  • Male participants, who anticipate being sexually active during the trial period (from first IMP administration until 13 weeks after the last IMP administration) with a woman who is either a WOCBP, a woman who is pregnant and/or breast feeding:  CONTRACEPTION REQUIRED: From the first day of dosing until the end of the systemic exposure of the trial drug. Acceptable methods are:  male condom with or without spermicide infertile male (e.g. vasectomised, permanently sterile following bilateral orchidectomy, or any other documented cause of infertility) Participants must agree not to donate sperm or ova from the time of the first administration of trial medication until three months after the end of the systemic exposure of the trial drug Participants must have a body weight of 50 kg or greater and a BMI between 18.0 kg/m² - 28.0 kg/m² (inclusive) at screening Satisfactory medical assessment with no clinically significant or relevant abnormalities as determined by medical history, physical examination, vital signs, 12-lead ECG and clinical laboratory evaluation (haematology, biochemistry, coagulation, and urinalysis) that is reasonably likely to interfere with the participant's participation in or ability to complete the trial as assessed by the Investigator Ability to provide written, personally signed, and dated informed consent to participate in the trial, in accordance with the ICH Good Clinical Practice (GCP) Guideline E6 (R2) (2016) and applicable regulations, before completing any trial-related procedures An understanding, ability, and willingness to fully comply with trial procedures and restrictions.  Exclusion Criteria:  Current or recurrent disease (e.g. cardiovascular, haematological, neurological, endocrine, immunological, renal, hepatic or gastrointestinal or other conditions, including cholecystectomy or gastrectomy) that could affect the action, absorption, distribution, metabolism or excretion of PYR or PQP or could affect clinical assessments or clinical laboratory evaluations Any history of seizures or epilepsy Any history of photosensitivity Any documented retinopathy History of malaria in the previous two years A score of 20 or more on the Beck Depression Inventory, and/or a response of 1, 2 or 3 for item 9 of this inventory (related to suicidal ideation) [26]. Current or relevant history of physical or psychiatric illness that are not stable or may require a change in treatment, or use of prohibited therapies during the trial, that make the participant unlikely to fully comply with the requirements of the trial or to complete the trial, or any condition that presents undue risk from the investigational product or trial procedures Any other significant disease or disorder which, in the opinion of the Investigator, may either put the participant at risk because of participation in the trial, or may influence the result of the trial or the participant's ability to participate in the trial The history or presence of any of the following cardiac conditions: known structural cardiac abnormalities; family history of long QT syndrome; cardiac syncope or recurrent, idiopathic syncope; exercise-related clinically significant cardiac events  Any clinically significant abnormalities in rhythm, conduction or morphology of resting ECG or clinically important abnormalities that may interfere with the interpretation of QTc interval changes. This includes participants with any of the following (at screening or Day -1):  sinus node dysfunction clinically significant PR >220 msecs (PQ) interval prolongation second- or third-degree atrioventricular (AV) block sustained cardiac arrhythmia's including (but not limited to) atrial fibrillation or supraventricular tachycardia, or any symptomatic arrhythmia, with the exception of isolated extra-systoles abnormal T-wave morphology which may impact on the QT/QTc assessment QT interval corrected using the Fridericia's formula (QTcF) >450 ms (males and females) any other ECG abnormalities in the standard 12-lead ECG and 24-hour 12 lead Holter ECG or an equivalent assessment which in the opinion of the Investigator will interfere with the ECG analysis Participants with borderline abnormalities may be included if the deviations do not pose a safety risk, and if agreed between the appointed cardiologist and the PI.  Has vital signs consistently outside of normal range at screening or Day -1. Acceptable normal range is as follows:  supine HR 40 - 100 bpm (after at least five minutes of supine rest)  supine blood pressure (after at least five minutes of supine rest):  systolic blood pressure: 90 - 140 mmHg diastolic blood pressure: 40 - 90 mmHg Has a positive test for Hepatitis B surface Antigen (HBsAg), Hepatitis C Antibody (HCV Ab), or Human Immunodeficiency Virus Antibody (HIV Ab) at screening Has total bilirubin, ALT or AST consistently >ULN at screening (up to two repeats may be taken during the screening period; volunteer may be included if two out of the three total results are ≤ULN), or has total bilirubin, ALT or AST>ULN on Day -1 (mild variations from baseline may be allowed if considered not clinically significant by the Investigator) Has a haemoglobin, platelet count, total white blood cell count, lymphocyte or monocyte count less than Lower Limit of Normal (LLN) (up to two repeats may be taken during the screening period and on Day -1 (participants may be included if two out of the three total results are greater or equal to LLN), at screening. Where there is a clear diurnal effect on the result participants may be included if variations are considered not clinically relevant by the Investigator Any other abnormal findings on vital signs, ECG, physical examination or laboratory evaluation of blood and urine samples that the Investigator judges as likely to interfere with the trial or pose an additional risk in participating Positive test results for alcohol or drugs of abuse at screening or Day -1 Female participants who are pregnant (including a positive serum pregnancy test at screening or on Day -1) or breastfeeding Male participants with a female partner(s) who is (are) pregnant or lactating at screening or on Day -1, or is (are) expected to be during the trial period History or clinical evidence of substance and/or alcohol abuse within the two years before screening. Alcohol abuse is defined as regular weekly intake of more than 14 units (for both males and females), using the following National Health Service (NHS) alcohol tracker https://www.nhs.uk/oneyou/for-your-body/drink-less/know-your-alcohol-units/ Treatment with an investigational drug within 90 days or five half-lives preceding the first dose of trial medication (whichever is the longer) Use of tobacco in any form (e.g. smoking or chewing) or other nicotine-containing products in any form (e.g. gum, patch, electronic cigarettes) within six months prior to the planned first day of dosing Has used any medication (see list for reference: https://www.fda.gov/drugs/drug-interactions-labeling/drug-development-and-drug-interactions-table-substrates-inhibitors-and-inducers#transporter ) that is either a moderate or strong inhibitor or inducer of CYP3A4 within 30 days or five half-lives (whichever is longer) prior to the planned first day of dosing Additionally, participants must have not consumed other substances known to be potent inhibitors or inducers of CYP3A4 system such as grapefruit or cranberry juice-containing products in the 30 days before the planned first IMP administration Has used any other prescription medication (excluding hormonal contraception and hormone replacement therapy) within 14 days or five half-lives (whichever is longer) prior to Day 1 of the dosing period that the Investigator judges is likely to interfere with the trial or pose an additional risk in participating Has used any over-the-counter medication (including multivitamin, herbal, or homeopathic preparations;) during the seven days or five half-lives of the medication (whichever is longer) prior to Day 1 of the dosing period, that the Investigator judges is likely to interfere with the trial or pose an additional risk in participating Consumption of any herbal remedies or dietary supplements containing a herbal remedy in the 30 days before the planned Day 1 of the dosing period Ingestion of any poppy seeds within the 24 hours prior to screening and admission Known or suspected intolerance or hypersensitivity to the investigational products, any closely related compound, or any of the stated ingredients History of significant allergic reaction (e.g. anaphylaxis, angioedema, but excluding untreated, asymptomatic, seasonal allergies) to any product (food, pharmaceutical, etc) Donation of blood or blood products (excluding plasma) within 90 days prior to trial medication administration Has a mental incapacity or language barriers precluding adequate understanding, co-operation, or compliance with the trial requirements An inability to follow a standardised diet and meal schedule or inability to fast, as required during the trial Inability to swallow eight tablets in short succession Participants with veins on either arm that are unsuitable for intravenous puncture or cannulation (e.g. veins that are difficult to locate, or a tendency to rupture during puncture) Prior screen failure (where the cause of the screen failure is not deemed to be temporary), randomisation, participation, or enrolment in this trial. Participants who initially failed due to temporary non-medically significant issues are eligible for re-screening once the cause has resolved Participants who have received or are planning on receiving a COVID-19 vaccination four weeks before first dose administration, or within one week after trial completion Any conditions which in the opinion of the Investigator would make the volunteer unsuitable for enrolment or could interfere with the participants' participation in or completion of the trial.