Inclusion Criteria:age >18 years  diagnosis of severe refractory asthma according to the ERS/ATS criteria ATS Blood eosinophils >150 cells/mcL at the screening visit and at least one value of 300 or more eosinophils/mcL during the previous year; at least two exacerbations despite maximal therapy with long-acting bronchodilators and high dose inhaled corticosteroids in the previous year or the need for continued therapy with oral corticosteroids in addition to maximal inhaled therapy for at least 6 months in the previous year written informed consent. For CRSwNP diagnosis, the EPOS 2020 guidelines will be considered as reference. All the above-mentioned inclusion criteria must be met.  Exclusion Criteria:Pregnancy  Eosinophilic Granulomatosis with Polyangiitis (EGPA); Serious life threatening cardiopulmonary disorders; Systemic immunologic disorder in the last 12 months; Positive history for malignant tumors ever in patient's life; Immunodeficiency.