Inclusion Criteria:  Indication for ASD surgery Indication for the use of bone graft Age ≥ 18 years old at the date of surgery  Exclusion Criteria:  ASA ≥ 4 Formally diagnosed with a disease affecting the bone metabolism or wound healing (severe osteoporosis, osteomalacia, Pagets disease, hyperparathyreoidism etc.) Disseminated cancer diseases Hypersensitivity to any of the i-FACTOR Peptide Enhanced Bone Graft ingredients Smoking, extensive alcohol use or abuse of hallucinating drugs Severe liver or kidney disorders Pregnancy or breastfeeding patients Patients estimated not to be able to understand the information sheet or patients, who do not consent to participate in the study. Severe psychiatric diseases Ongoing infections