Inclusion Criteria:  Male or female patients 18 to 65 years of age (inclusive) Diagnosed with bipolar I disorder, manic or mixed-type, per DSM-5 criteria Voluntary hospitalization for current manic episode  Exclusion Criteria:  Patients with a DSM-5 diagnosis of a psychiatric disorder other than bipolar I disorder that was the primary focus of treatment within the previous six months Patients who are experiencing a first manic episode or meeting criteria for rapid cycling