Inclusion Criteria:  Referral to pulmonary services for pleuroscopy with biopsies and indwelling pleural catheter (IPC) placement Age > 18  Exclusion Criteria:  Inability to provide informed consent  Study subject has any disease or condition that interferes with safe completion of the study including:  Allergic reaction to EXPAREL Need for pleurodesis No placement if IPC Previous ipsilateral thoracic surgery Allergies to lidocaine or other local anesthetics, narcotics, non-steroidal anti-inflammatory drugs (NSAIDs) or acetaminophen Pregnancy Advanced liver disease where the clinician deems the procedure unsafe