Inclusion Criteria:  Male or female ≥50 years old; Able to read, understand and sign informed consent The investigator believes that the subjects can understand the process of the clinical study, are willing and able to complete all study procedures and follow-up visits, and cooperate with the study procedures Patients requiring colonoscopy  Exclusion Criteria:  Have drug or alcohol abuse or mental disorder in the last 5 years Pregnant or lactating women Patients with known multiple polyp syndrome; patients with known inflammatory bowel disease; known intestinal stenosis or space-occupying tumor; known colon obstruction or perforation; patients with a history of colorectal surgery; Patients with previous history of allergy to pre-used spasmolysis; Unable to perform biopsy and polyp removal due to coagulation disorders or oral anticoagulants; High risk diseases or other special conditions that the investigator considers the subject unsuitable for participation in the clinical trial.