Inclusion Criteria:  Age: 19 - 70 patients receiving hematopoietic stem cell transplantation HBV serologic test: HBsAg (-), anti-HBc IgG (+) ECOG performence: 0-2 patients with informed consent  Exclusion Criteria:  HBV DNA (+, ≥10 IU/mL) at the time of screening Receiving hematopoietic stem cell transplantation from donor with HBsAg+ Combined other chronic liver disease (severe alcoholics, autoimmune hepatitis, chronic hepatitis C etc.) HIV (+) Previous antiviral therapy history for chronic hepatitis B Other concomitant malignancy combined autoimmune disease (rheumatic arthritis, SLE etc) CTP class B, C Decompensated complications (ascites, hepatic encephalopathy etc.) active tuberculosis