Inclusion Criteria for CMT Patients  Age ≥ 18 years Diagnosis of CMT confirmed by: Clinical presentation and electro diagnostics or genetics Physical Features (all must apply): 1) Ambulation for at least 10 meters, without a brace 2) Left and right ankle plantar flexion Medical Research Council (MRC) grade 2 to 5, inclusive 3) Left and right ankle dorsiflexion MRC manual muscle testing (MMT) grade 2 to 4+, inclusive. Ability to adhere to the study visit schedule/procedures, and to understand and comply with protocol requirements Stable concomitant medications for 2 months prior to enrolment Signed written informed consent  Exclusion Criteria for CMT Patients  Severe deformity or ankle contracture that would sufficiently limit passive range of motion to affect assessment of dorsiflexion strength Ulceration that would interfere with functional ability Recent major surgery Significant change in physical activity or exercise (e.g., significant increase or decrease in intensity or frequency) within 8 weeks before Study Day 1 or inability to maintain the baseline level of physical activity throughout the study Any disability or condition that would prevent completion of the study tasks Moderate to severe Neuropathic or inflammatory/musculoskeletal pain that would interfere with performance of the tests A diagnosis of a primary NMJ disorder such as myasthenia gravis, Lambert Eaton Myasthenic Syndrome or congenital myasthenic disorder  Inclusion Criteria for Healthy Volunteers  Healthy male or female volunteers Age ≥18 years Able to give written informed consent  Exclusion Criteria for Healthy Volunteers  Pregnant Requiring prescription medicines likely to interfere with electromyography (EMG) recordings Presence of current or previous medical condition which might interfere with participation in the study