Inclusion Criteria:  Participants with diagnosis of AD for at least 6 months. Participants with an overall and a face and/or neck IGA score of 2 or 3 at screening and baseline.  Participants with AD affecting the following at screening and baseline:  ≥ 0.5% of the total BSA on the face and/or neck Up to a total of 20% BSA (face and/or neck plus other body areas) Willingness to avoid pregnancy or fathering children based on the criteria outlined in the protocol. Further inclusion criteria apply.  Exclusion Criteria:  Participants who have an unstable course of AD (spontaneously improving or rapidly deteriorating) as determined by the investigator over the previous 4 weeks prior to baseline. Participants with concurrent conditions and history of other diseases such as immunocompromised; chronic or acute infection requiring systemic treatments; active acute skin infection; other concomitant skin conditions that may interfere with the evaluation of AD or compromise participant safety; other types of eczema; chronic asthma requiring high dose of inhaled corticosteroids. Any serious illness or medical, physical, or psychiatric condition(s) that, in the investigator's opinion, would interfere with full participation in the study, including administration of study drug and attending required study visits; pose a significant risk to the participant; or interfere with interpretation of study data. Previous treatment with systemic or topical JAK inhibitors (eg, ruxolitinib, tofacitinib, baricitinib, filgotinib, lestaurtinib, pacritinib). Participants who are pregnant (or who are considering pregnancy) or lactating. Laboratory values outside of the protocol -defined criteria Further exclusion criteria apply.