Subject Inclusion Criteria:  The age of 19 years or older Diagnosis of open-angle glaucoma (POAG) or ocular hypertension (OH) Intraocular Pressure(IOP) ≤ 35mmHg at both eye and IOP ≥ 22mmHg at either eye Shaffer's grading > 2 Best-corrected visual acuity in both eye equivalent to 0.2logMar Able and willing to give signed informed consent  Subject Exclusion Criteria:  Central corneal thickness <500㎛ or >600㎛  Medical history of following  Closed-angle glaucoma, pigment dispersion syndrome, pseudoexfoliation, narrow-angle glaucoma Advanced glaucomatous loss; mean deviation (MD) < -12dB Moderate to severe inflammatory/infectious disease in either eye Advanced retinopathy Surgical or laser therapy for glaucoma treatment  Have confirmed the following at the screening visit  SBP ≥ 180mmHg or DBP ≥ 110mmHg HbA1c > 9.0% CrCl < 30mL/min AST or ALT ≥ 3 X ULN Unstable angina, myocardial infarction, transient ischemic attack, cerebral stroke, coronary artery bypass graft, or coronary angioplasty within 24 weeks History of malignant tumor with 5 years History of the causative disease that may cause secondary glaucoma, including a history of steroid administration for more than 4 weeks Conditions need to wear contact lenses during the study Known hypersensitivity to any component of the investigational product  Who has administered topical/systemic drugs that may affect the study within a certain period prior to eligibility check or are expected to need administration during the study duration  Prostaglandin analogues: 5 weeks β-blockers: 4 weeks ROCK inhibitors: 4 weeks α/β-adrenergic agonists: 2 weeks Muscarinic agonists: 1 week Carbonic anhydrase inhibitors: 1 week Systemic corticosteroids: 4 weeks Pregnant or breast-feeding Who disagreed with the use of the methods of proper contraception during the study duration Administration or use of other investigational drugs/devices prior to the screening visit within its 5 half-lives or 30 days, whichever is longer Unsuitable for participation in the study according to the judgment of the investigator