Inclusion Criteria:  Participants are able to provide signed and dated written informed consent prior to any study specific procedures Participants should have suitable veins for cannulation or repeated venipuncture Women are post-menopausal (defined as at least 1 year post cessation of menses) Aged ≥ 45 and ≤ 75 years Body mass index (BMI) 27 - 38 kg/m2 Stable dietary habits (no weight loss or gain >5kg in the past 3 months) Sedentary lifestyle (not more than 2 hours of sports per week) No signs of active cardiovascular disease, liver or kidney malfunction Liver fat content ≥ 2% weight/weight.  Exclusion Criteria:  Type 2 diabetes Previous enrolment in a clinical study with an investigational product during the last 3 months or as judged by the Investigator Patients with congestive heart failure and and/or severe renal and or liver insufficiency or another condition that may interfere with outcomes measured in this study. Any contra-indication MRI scanning Alcohol consumption of >2 servings per day for men and >1 servings per day for woman Smoking in the past 6 months Men: Hb <8.4 mmol/L, Women: Hb <7.8 mmol/l Vegetarian, vegan, food intolerant to common foods (e.g. gluten intolerant, lactose intolerant) Medication use that may influence outcome parameters  A medical doctor will judge participation eligibility based on the medical history questionnaire, medication use and fasting blood parameters. If the medical doctor advises that a volunteer cannot participate, the volunteer will be excluded from enrollment.