Inclusion Criteria:  Patients ≥18 years old of both genders. Patients diagnosed as confirmed COVID-19 when they have a positive result of RT-PCR for SARS-CoV-2 RNA or confirmed diagnosis by typical clinical picture and radiological methods , according to the WHO and Egyptian Ministry of Health and Population (MOH) definitions, at Assiut University Hospital.  Exclusion Criteria:  Children less than 18 years. Patients refusal to participate in the study