Inclusion Criteria:  Age ≥ 18 years; Supratentorial non-traumatic ICH confirmed by CT, without a confirmed causative lesion on admission CT-angiography (e.g. aneurysm, AVM, DAVF, cerebral venous sinus thrombosis) or other known underlying lesion (e.g. tumour, cavernoma); Minimal intracerebral haemorrhage volume of 10 mL; Intervention can be started within 8 hours from symptoms onset; Patient's or legal representative's informed consent.  Exclusion Criteria:  Severe ICH, unlikely to survive the first 72 hours (defined as Glasgow Coma Scale score < 6 at time of consent); Confirmed or suspected haemorrhagic transformation of an arterial or venous infarct; Planned neurosurgical haematoma evacuation; Severe infection at admission, requiring antibiotic treatment; Known active tuberculosis or active hepatitis; Use of immunosuppressive or immune-modulating therapy at admission (see 15.1 Appendix A); Neutropenia (Absolute Neutrophil Count (ANC) <1.5 x 109/L ); Pre-stroke modified Rankin Scale score ≥ 3; Pregnancy or breast-feeding; Standard contraindications to MRI (see 15.2 Appendix B); Known prior allergic reaction to gadolinium contrast or one of the constituents of its solution for administration; Known allergy to anakinra or other products that are produced by DNA technology using the micro-organism E. coli; Live vaccinations within the last 10 days prior to this ICH; Severe renal impairment (eGFR <30ml/min/1.73m)