Inclusion Criteria:  Signed and dated written informed consent Age ≥ 45 years at time of screening Preserved systolic left ventricular function, defined by left ventricular ejection fraction (LVEF) ≥ 50% NYHA classes II-IV H2FPEF score ≥ 6 or HFA-PEFF score ≥ 5  Exclusion Criteria:  Patients with a known history of angioedema History of hypersensitivity to ARNI Any prior echocardiographic measurement of LVEF <45% Significant congenital heart disease Rheumatic valvular heart disease Acute coronary syndrome, cardiac surgery, other major cardiovascular surgery Probable alternative diagnoses could account for the patient's HF symptoms Systolic blood pressure(BP) >180 mm Hg or diastolic BP >120 mm Hg at visit Diastolic BP <90 mm Hg at visit 1, or symptomatic hypotension Patients with a cardiac pacemaker therapy device eGFR <30 ml/min/1.73 m2 Serum potassium >5.2 mmol/l at visit 1 Pregnant or nursing women