Inclusion Criteria:  Diagnosed case of Hepato-pulmonary syndrome AaPO2 > 15 mm Hg on standing room air arterial blood gas (ABG). PaO2<80 mmHg for clinical HPS between 18-70 years of years Child A/B cirrhosis, Child C with CTP score of =/<10 Patient with no liver transplant option  Exclusion Criteria:  Child-C cirrhosis CTP >10 Very Severe HPS Acute-on-chronic liver failure Thrombosis of splenoportal axis Hepatocellular carcinoma Renal dysfunction Patients intolerant to beta blockers (history of hypotension or bradycardia) Contraindication for beta-blockers (history of chronic obstructive pulmonary disease, atrioventricular block) Pregnant females Refusal to participate in the study Hepatic Hydrothorax