Inclusion Criteria:  ≥ 18 years of age and plan to undergo cataract surgery Prior use of DED/keratitis conservative treatments (artificial tears, ointment, Xiidra®, Restasis, warm compresses, etc.) within 30 days Moderate to severe DED/keratitis (SPEED score ≥ 10) Total cornea fluorescein staining score ≥ 4 (NEI scale) Topographic changes such as irregularity, dropout, and higher order aberrations (HOAs; RMS > 0.4) as determined by the investigator  Distorted keratometry mires or inconsistent biometry between 2 consecutive readings (30s apart) as determined by the investigator  Exclusion Criteria:  Use of soft contacts lens, bandage contact lens, or scleral lens within 7 days Ocular surgery within 3 months History of refractive surgery (LASIK, keratectomy, radial keratotomy, etc.) History of clinically significant ocular trauma Significant posterior corneal astigmatism (≥ 0.75 D) History of herpetic keratitis Ongoing ocular or systemic infection Visually significant retinal pathology Clinically significant findings observed at screening, including lid abnormalities, epithelial basement membrane dystrophy, Salzmann's nodular degeneration, subclinical or clinical keratoconus (defined as KISA% index > 6019), ectasia (Belin/Ambrosio enhanced ectasia display final 'D' index > 2.6920), Fuchs' endothelial corneal dystrophy (Using the Classification by Sun et al21), etc. Short eyes (axial length < 22 mm22, 23) High myopia (axial length ≥ 26 mm)22, 24 Eyes with glaucoma drainage devices or filtering bleb Patients with a history of drug reactions to Ciprofloxacin, Amphotericin B, Glycerol, and/or DMEM. Patient cannot close the eyelid, has an incomplete blink, or demonstrates any other signs of exposure that cannot be addressed by the investigator Pregnancy or subject expecting to be pregnant Use of additional eye medications (i.e. glaucoma eye drops, anti-histamines, etc)