Inclusion Criteria:  Age 18-65 years old ASA classification I-II grade Body mass index (BMI) 18-30kg/m2  Exclusion Criteria:  Patients with paresthesia or pruritus Drug and alcohol abuse Allergies to lipid drugs and contraindications; corticosteroids are cautious Patients Hyperlipidemia Patients during pregnancy and lactation Mental diseases, communication disorders Patients who use hormones for a long time