Inclusion Criteria:  Patients between 20 - 65 years of ages Patients who agree to participate this study Not taking analgesic or antibiotics in the last week Single root and single-canal incisor, canine, premolar teeth that have been treated only once before Teeth with previous endodontic treatment but with insufficient root canal filling on radiographic examination Teeth with periapical lesions and at least 2 years since the previous treatment, although root canal filling seems sufficient Periapical radiolucency, teeth with increased or unchanged according to pre-treatment radiography (if available) Teeth are asymptomatic Patients who had good oral hygiene  Exclusion Criteria:  Pregnant patients and patients in lactation period Having used corticosteroids in the last 6 months Individuals with systemic diseases (endocarditis, immune system diseases,etc.) requiring antibiotic prophylaxis Having received immunosuppressive therapy within the last week Patients who had systemic or allergic sensitivty for the NSAIDs and local ananesthetics The presence of advanced periodontal disease (probing depth > 4 mm) The presence of a foreign body in the root canal that prevents entry (broken file, post, etc.) Fracture or crack in the root Teeth that cannot reach the working length due to calcification in the root canal and step formation Teeth that cannot be restored due to excessive loss of material in the coronal structure The presence of more than one adjacent tooth requiring endodontic treatment that may cause reflected pain in the same patient. Teeth that develop any complications ( breakage of endodontic file, perforation, inability to determine the working length with the apex finder) during the removal of the canal filling material.