Inclusion Criteria:  Any sex, gender orientation, and ethnicity Between ages 30 and 70 Must be willing and able to participate in venipuncture, health history and clinical assessments, passive monitoring (Oura ring), and continuous in-home Blushield device usage  Exclusion Criteria:  Significant change in diagnosis and/or treatment of major illness or injury within 2 years prior to screening, e.g., diabetes, cancer, cardiovascular disease, psychiatric condition 2. Any ongoing immune system concerns or immunodeficiency disease History of any viral illness in preceding year Body mass index (BMI) > 35 kg/m2 Presence of active infection Any other illness, disorder, alcohol or chemical dependence that in the opinion of investigators would render study participation unsuitable Unable or unwilling to provide required biological sample Unable or unwilling to avoid pregnancy during study period