Inclusion Criteria:  New or first recurrent diagnosed as major depression disorder. Having total score HAM-D 17 ≥ 17 point  Exclusion Criteria:  Can not answer the question in HAM-D 17 Having psychosis, anxiety disorder, obsessive-compulsive disorder Having risk of suicide now or 3 months past having medical history: diabetes mellitus, hypothyroidism, hypopituitarism, epilepsy, renal failure, heart failure, stroke, myocardial infarction, liver failure, cirrhosis. Pregnancy