Inclusion Criteria:  Male 18 years or older; Histologically or cytologically confirmed diagnosis of prostate cancer; Patient must have had previous treatment with definitive surgery or radiation therapy, cryoablation, or brachytherapy; Patient may have prior salvage therapy (surgery, radiation or other local ablative procedures) within 6 months prior to randomization if the intent was for cure. Prophylactic radiotherapy to prevent gynecomastia within 4 weeks prior to randomization is allowed  Patient must have evidence of biochemical failure after primary therapy and subsequent progression. Biochemical failure is declared when the PSA reaches a threshold value after primary treatment and it differs for radical prostatectomy or radiation therapy:  For radical prostatectomy the threshold for this study is PSA ≥ 0.8ng/mL For radiation therapy the threshold is a PSA rise of 2 ng/mL above the nadir PSA achieved post radiation with or without hormone therapy (2006 RTOG-ASTRO Consensus definition). PSA progression requires a PSA rise above the threshold measured at any time point since the threshold was reached; PSA doubling time ≤ 12 months. PSA calculation requires two consecutive PSA rises (PSA2 and PSA3) above the threshold PSA (total 3 PSA values); PSA2 and PSA3 must be obtained within 12 months of study entry. All baseline PSAs should be obtained at the same reference lab. ECOG performance status less than or equal to 2; Ability to swallow the study drugs; If a male with a female partner of child bearing potential, adequate methods of contraception must be employed; If male, no sperm donation for 90 days until after the conclusion of the study; Be properly informed of the nature and risks of the clinical investigation, comply with all clinical investigation-related procedures, and sign an Informed Consent Form prior to entering the clinical investigation; Be able to participate for the full term of the clinical investigation; Have a Karnofsky performance status of >70; Have a life expectancy ≥ 6 months; and Have adequate baseline organ function (hematologic, liver, renal, nutritional and metabolic):  Hematology:  Absolute neutrophil count (ANC) ≥1.5 Hemoglobin ≥ 10 g/dL Platelets ≥ 100,000 per microliter of blood  Hepatic:  Total bilirubin ≤ 2 x ULN Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) ≤2.5 x ULN  Renal:  creatinine clearance (CrCl) ≥ 60 ml/min within 2 weeks prior to registration determined by 24-hour collection or estimated by Cockcroft-Gault formula: CrCl male = [(140 - age) x (wt in kg)] [(Serum Cr mg/dl) x (72)] CrCl female = 0.85 x (CrCl male)  Exclusion Criteria:  Evidence of metastatic disease on imaging studies (CT and/or bone scan);  Diagnosis of diabetes mellitus defined as:  Fasting blood glucose > 126 mg/dl or, Random blood glucose > 200 mg/dl Hemoglobin A1C > 6.5% Patients with QTc >480 msec Need for treatment with any conventional modality for prostate cancer (surgery, radiation therapy, and hormonal therapy); Treatment within the last 30 days with any investigational drug; Radiation therapy within prior 6 months (prophylactic radiotherapy to prevent gynecomastia within 4 weeks prior to randomization is allowed); Patient with previous or concurrent malignancy. Exceptions are made for patients who meet any of the following conditions: Basal cell or squamous cell carcinoma of the skin or prior malignancy that has been adequately treated and patient has been continuously disease free for ≥ 2 years; Evidence of a significant medical illness, or a psychiatric illness/social situation that would, in the investigator's judgment, make the patient inappropriate for this study; Refractory nausea and vomiting, malabsorption, biliary shunt, or significant bowel resection that would preclude adequate absorption of the study drug; Have had a recent, serious, non-malignant medical complication that, in the opinion of the investigator, makes the individual unsuitable for study participation; Have used an investigational drug within 28 days of the initiation of study treatment; Have a history of a positive blood test for HIV; At the time of screening, have a significant active medical illness which, in the opinion of the investigator, would preclude completion of the study; and Body weight less than 35 kg (77 lbs.)