Inclusion Criteria:  1. Histopathologically confirmed rGBM 2. Age18-65 3. Participants had undergone maximal surgical resection 4. Amount of dexamethasone was not more than 2mg/ days 5. Ability and willingness to sign informed consent 6. Karnofsky Performance Score of 70 or more 7. Normal liver and kidney function 8. Not accepted other treatment plan during the immunotherapy  Exclusion Criteria:  1. Not conforming to the standard 2. Systemic illness or medical condition may pose additional risk,including cardiac, incompensated renal or liver function abnormalities;inflammatory and immune system diseases of rheumatic arthritis 3. Received other drugs for glioma therapy 60 days before participated 4. Allergy to immune adjuvant 5. Nervous system disease and diffuse leptomeningeal disease 6. Amount of dexamethasone was more than 2mg/days during the immunotherapy 7. Pregnant or lactation