Inclusion Criteria:  Diagnosis of cystic fibrosis confirmed by the identification of genetic mutation and/or positive sweat test regular follow-up in CF centers ; age higher than 6 years old stable clinical status, away from exacerbation period or antibiotic treatment.  Exclusion Criteria:  transplant patient or patient waiting for a transplant inability to fill in the questionnaire or to complete the planned evaluations ongoing participation in another research protocol (interventional study) refusal to participate in the study patient under legal protection.