Inclusion Criteria:  Body mass index (BMI) of 18.0 to 30.0 kg/m^2, inclusive Body weight ≤100 kg. Must agree to adhere to the requirements on contraception, exposure to sexual partners, and sperm donation as defined in the protocol Additional criteria apply.  Exclusion Criteria:  Received any investigational drug in a clinical research study within the last 90 days History of alcohol abuse or drug addiction (including soft drugs like cannabis products) within past 5 years. Regular alcohol consumption Positive drug, nicotine (cotinine), or alcohol screen Current smokers, user of e-cigarettes and nicotine replacement products and those who have used these products within the last 3 months Have a pregnant partner Clinically significant abnormal clinical chemistry, hematology (including coagulation), or urinalysis Positive hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) antibody or human immunodeficiency virus (HIV) results Positive nasopharyngeal polymerase chain reaction (PCR) test for severe acute respiratory syndrome Covid Virus-2 (SARS-CoV-2) on Day -1 or within 8 weeks prior to screening. Contact with COVID-19 positive (or suspected) persons within 14 days prior to first dose Active renal and/or hepatic disease History of clinically significant cardiovascular, renal, hepatic, endocrine, metabolic, respiratory, gastrointestinal (GI), neurological, or psychiatric disorder Abnormalities in brain and lumbar spine, or other medical or surgical conditions or clinically significant abnormal findings, for which lumbar puncture is contraindicated History of clinically significant back pain, back pathology and/or back injury History of significant active bleeding or coagulation disorder or have taken non-steroidal anti-inflammatory drugs or other drugs that affect coagulation or platelet function within 14 days prior to lumbar puncture Allergy to lidocaine (Xylocaine®) or its derivatives Any form of cancer within the 5 years (exceptions apply) History and/or symptoms of adrenal insufficiency Have a condition that could be aggravated by glucocorticoid antagonism Donation or loss of greater than 400 mL of blood within the previous 3 months Currently using glucocorticoids or have a history of systemic glucocorticoid use at any dose within the last 12 months or 3 months for inhaled products Additional criteria apply.