Inclusion Criteria:  Provision of signed and dated informed consent form Stated willingness to comply with all study procedures and availability for the duration of the study Stated willingness to comply with lifestyle considerations Male or female, 18 years or older presenting in long-term care facilities, out-patient department or in-hospital patients with a stage II, III or IV pressure injury with or without local signs of infection with a size not exceeding 28 cm2 Within 72 hours before randomization, pressure injury specimen positive for S. aureus, P. aeruginosa, or K. pneumoniae determined by qPCR or rapid diagnostic test or conventional method or positive growth on specific agar. For females of reproductive potential: use of a highly effective contraception for at least 1 month prior to screening and agreement to use such a method during study participation and for an additional 4 weeks after the end of administration of the study intervention For males of reproductive potential: use of condoms or other methods to ensure effective contraception with partner.  Exclusion Criteria:  Diagnosis of Kennedy terminal ulcer, Trombley-Brennan terminal tissue injuries or skin changes at life's end (SCALE). Pregnancy or lactation. Known allergic reactions to components of SilvaSorb hydrogel. Known allergic reactions to components of the phage treatment; including known allergic reactions to bacteriophages, polyester amide urea polymers and/or TMN buffer. Unstable coronary artery disease. Patients diagnosed with Type I or Type II diabetes, uncontrolled (HgbA1c >8% or 2+ glycosuria). Treatment with another investigational drug or other intervention within 30 days. Intercurrent condition requiring a high dose of chronic corticosteroid therapy, immunosuppressive medication, oncologic chemotherapy. Patients who have additional uncontrolled serious medical or psychiatric illness determined by the investigators where the patient is unfit to receive the product. Chronic stool incontinence without a rectal tube if an individual has a sacral ulcer. Placement of a wound vacuum. Surgical wound closure planned within the study period. Organ failure, acute respiratory failure and chronic renal failure. Diagnosed osteomyelitis.