Inclusion Criteria for All the Participants:  Ability to provide a written informed consent 40-75 years old Ability to comply with study procedures  Exclusion Criteria for All the Participants:  Pregnancy or lactating women Recipients of organ transplant or prior non-autologous (allogeneic) bone marrow transplant or stem cell transplant Recipients of blood transfusion within 7 days prior to study blood draw Recipients of any anti-cancer therapy within 30 days prior to study blood draw, due to diseases other than cancer  Inclusion Criteria for Cancer Arm Participants:  Confirmed diagnosis or suspicious cases of cancer within 42 days prior to study blood draw. No prior anti-cancer therapy (local or systematic) prior to study blood draw  Exclusion Criteria for Cancer Arm Participants:  Known prior or current diagnosis of other types of malignancies or multiple primary tumors Diagnosis of benign diseases by histopathological assessments No confirmed diagnosis of cancer by histopathological or radiological assessments within 42 days of study blood draw, or inability to characterize whether the lesion is malignant or benign Non-small-cell lung cancer patients with ground-class nodularity by radiological examination Diagnosis of precancerous lesions  Inclusion Criteria for Healthy Arm Participants:  No cancer-related symptoms or discomfort within 30 days prior to study blood draw No clinically significant finding by physical examinations, hematological assessment, urinalysis, LDCT or ultrasound No clinically significant finding by breast ultrasound or Molybdenum Target Mammography Detection, or Thinprep cytologic test (TCT) detection for female participants No active hepatitis B or hepatitis C infection  Exclusion Criteria for Healthy Arm Participants:  Prior or ongoing treatment of cancer within 3 years prior to study blood draw Clinically significant or uncontrolled comorbidities