Inclusion Criteria:  Participation in the prospective Haga, HMC or LUMC cohort Clinical diagnosis of SSc Age of ≥18 years >= two evaluations in the Care Pathway Low or intermediate risk for disease progression according to the prediction model Written informed consent  Exclusion Criteria:  Patients with SSc who are part of ongoing (randomized) trials Patients who have had an autologous stem cell transplantation in the past five years Patients with SSc who were categorized as high risk for disease progression according to the prediction model.