Inclusion Criteria:  Couples eligible for a first attempt at Assisted Reproduction (AMP). Couples asking for Assisted Reproductive Technology, and requiring an ICS procedure. Women aged 18 to 36 inclusive. Men aged 18 to 58 inclusive Use of CSCM-C culture medium from Biocare / Irvine, exclusively. People affiliated to a Social Security scheme  Exclusion Criteria:  Lack of consent Early menopause. Couples under IVF or Intra Uterine Insemination treatment. Patients resumed after a first attempt by the couple. People unable to follow protocol visits in France. Couple with a contraindication to treatment with ART. Women with a contraindication to treatment with ART or an associated pathology such as: hypertension, risk of eclampsia, viral risk, family genetic problems, diabetes, uterine partitions, synechiae adhesions, adenomyosis or any other contraindication judged as such by the investigator. AMP with donation of gametes or embryos. Frozen sperm. Participant under guardianship or guardianship