Inclusion Criteria:  Given informed consent 18 - 75 years of age Glasgow scale higher than 6 and smaller than 12 at the trauma scene moderate or severe acute traumatic brain injury all genders brain CT scan with signs of acute intraparenchymatous contusion  Exclusion Criteria:  Previous use of biperiden history of epilepsy (confirmed by patient chart) History of seizures or use of antiepileptic medication family history of epilepsy pregnancy participation in another clinical trial at the time of randomization History of neoplasia, neurodegenerative diseases; history of stroke, cognitive impairment, benign prostatic hyperplasia, atrioventricular block or any other cardiac arrhythmia, or glaucoma;