Inclusion Criteria:  Men and women Age 18 - 70 years BMI 18,5-25 for normal weighed and BMI 25-39 for overweighed/obese Hb ≥ 120g/L Serum TSH <4,0 mIU/L Signed informed consent  Among the overweighed, they need to have waist circumference > 102 cm/88 cm for men and women respectively. All overweighed participants must have one of the following risk factors for cardiovascular decease, whereas the normal weighed could have or not elevated risk factors:  LDL ≥ 3,0 mmol/L HDL ≤1.04 mmol/L Total cholesterol ≥ 5.0 mmol/L Triglycerider ≥1.69 mmol/L Blood pressure ≥130/85 mmHg Fasting glucose ≥6.1 mmol/L.  Exclusion Criteria:  Blood donation or participation in a clinical study with blood sampling within 30 days prior to screening visit and throughout the study. Following any weight reduction program or having followed one during the last 6 months Food allergies or intolerances Vegetarian or other diet restrictions (due to the standardized meal plan) History of stomach or gastrointestinal conditions (Inflammatory bowel disease, Crohn's disease, malabsorption, colostomy, bowel resection, gastric bypass surgery etc.) Previous major gastrointestinal surgery Pregnant or lactating or wish to become pregnant during the period of the study. Unable to understand written and spoken Swedish Lack of suitability for participation in the trial, for any reason, as judged by the medical doctor or PI. Pharmacological medication with drugs known to affect the microbiota, e.g. antibiotics, within 6 months prior to baseline. Intake of probiotics within 6 months prior to baseline. Have type I diabetes Receiving pharmacological treatment for type II diabetes (treatments based on life style interventions are acceptable, as long as it is compatible with the study protocol) Using nicotine products on a daily basis (including chewing gum, patches, snus etc.) History of heart failure or heart attack (TIA) within 1 year prior to screening Thyroid disorder