Inclusion Criteria:  age 50-65yr BMI 18.5-30kg/m2 Willing to avoid consumption of foods rich in Taxifolin/DHQ and Ergothioneine during the study period Willing to avoid taking any other food supplements or high doses of vitamins during the study period Able to provide written informed consent.  Exclusion Criteria:  Use of prescription medication which may influence immune function, such as anti-inflammatory or immunosuppressant medication Diabetes requiring any medication Liver cirrhosis A history of drug or alcohol misuse Asplenia or other acquired or congenital immunodeficiencies Any autoimmune disease including connective tissue diseases Malignancy Laboratory confirmed SARS-CoV-2 infection within last 3 months self-reported symptoms of acute or recent infection (including use of antibiotics within the last 3 months)