Inclusion Criteria:  COPD patients under Respiratory clinic UKM follow up  Patients who are with stable COPD (no exacerbation past 2 months) Age same and more than 40-year-old Patient able to perform inhaler medication Patient able to perform technically acceptable pulmonary function test  Exclusion Criteria:  Drug hypersensitivity Bronchial Asthma Significant disease that may influence patient's ability to participate in the study. Unable to provide signed informed consent Mental condition rendering the subject unable to understand the nature, scope and the possible consequences of the study.