Inclusion Criteria:  Severe acute respiratory syndrome coronavirus2 (SARS-CoV-2) infection Within 7 days from the onset of clinical symptoms or 4 days from the onset of severe symptoms Consistent with the National Health Committee New Coronavirus pneumonia diagnosis and treatment plan (Eighth Edition), general or heavy diagnostic criteria.  Exclusion Criteria:  Sever Covid-19 Infection patients SARS-Cov-2 specific antibodies (including IgM and IgG) were positive before included Cardiac function grade III or IV, or left ventricular ejection fraction < 30% History of known or suspected active pulmonary tuberculosis or extra-pulmonary tuberculosis Chronic renal failure needs maintenance dialysis History of solid malignant/tumor or hematological malignancy Pregnancy or lactation