Inclusion Criteria:  Participants in the study are children 9 to 17 years old. Obtained written informed consent from parents or gave-givers as well as obtained verbal informed consent from the child to participate in the study, in which procedures are explained in age-appropriate manner. Children, identified as positive or definitely positive through Frankl behavioral rating scale. Presence of at least four initial carious lesions of smooth surface (white spots) in permanent teeth that reach the inside of the enamel but are not cavitated, estimated with ICDAS system values 01 (first visible enamel change) and 02 (localized visible enamel change), Nyvad caries activity criteria (1 -active, noncavited lesion) and DIAGNOdent pen values up to 24. Study participants did not conduct remineralizing or topical fluorine therapy of the lesions involved up to six months prior to inclusion in the study. Children without a history of allergy to the administered medications  Exclusion Criteria:  Patients with general diseases or conditions associated with decreased salivation and intake of medications suppressing salivary current. Children with cognitive and behavioral disorders. The presence of a disease is confirmed by an anamnestic interview with the parent. Children with a history of allergy to the administered medications Patient with non-carious lesion such as enamel hypoplasia, or any developmental defects. Patient received restorations or any remineralizing agent other than the regular toothpaste during the last 6 months. Participant in another trial.