Inclusion Criteria:  American society of anesthesiologists I-III, scheduled for elective non-cardiac surgery under general anesthesia  Exclusion Criteria:  Patients with severe cardiac morbidities (impaired contractility with ejection fraction < 50%, heart block, arrhythmias, tight valvular lesions, metabolic equivalent less than 4), patients on angiotensin converting enzyme inhibitors and angiotensin receptor blockers medications, patients with uncontrolled hypertension, patients with body mass index <18 or > 35 Kg/m2, patient with allergy of any of the study drugs