Inclusion Criteria:  It is diagnosed as non-small cell lung cancer by pathological examination or cytological examination; it is assessed as locally advanced, unresectable stage III non-small cell lung cancer by imaging; Plan to receive radical radiotherapy and chemotherapy ± immunotherapy; Male or female between 18 and 75 years old; Life expectancy ≥ 12 weeks; The World Health Organization (WHO) PS score is 0 or 1; Organ and bone marrow function meet the following conditions: Forced expiratory volume per second (FEV1) ≥1000 ml; absolute neutrophil count ≥1.5×10^9/L; platelets ≥100×10^9/L; hemoglobin ≥90 g/L ; Serum creatinine clearance calculated according to the Cockcroft-Gault formula ≥50 mL/min (Cockcroft and Gault 1976); serum bilirubin ≤1.5 times the upper limit of normal (ULN); alanine aminotransferase and aspartate aminotransferase ≤2.5 times ULN; A signed informed consent form is required before proceeding with any step in the research; There is an abnormality in the initial cardiac output index.  Exclusion Criteria:  PS score 2-4; Organ function impairment: FEV1 <1000ml; absolute neutrophil count <1.5×10^9/L; platelets <100×10^9/L; hemoglobin <90 g/ L; Serum creatinine clearance calculated according to Cockcroft-Gault formula <50 mL/min; serum bilirubin>1.5 times ULN; alanine aminotransferase and aspartate aminotransferase>2.5 times ULN; Unstable angina or myocardial infarction occurred in the past month; Arrhythmia that has not been controlled and can cause symptoms or abnormal hemodynamics; Active endocarditis; Symptomatic severe aortic stenosis; Heart failure that has not been controlled; Acute pulmonary embolism, pulmonary infarction or low thrombosis (artery or vein) formation; Suspected or confirmed aortic dissection; Uncontrolled bronchial asthma; Pulmonary edema; Fingertip blood oxygen saturation at rest ≤85%; Acute non-cardiopulmonary diseases (such as infection, renal failure, thyrotoxicosis, etc.) that may affect sports performance or aggravate due to exercise; Mental disorders make it impossible to cooperate.