Inclusion Criteria:  Age ≥ 18 Diagnosis of COVID19 by validated SARS-CoV-2 antigen, RT-PCR, or other molecular diagnostic assay, using an appropriate sample such as NP, nasal, oropharyngeal [OP], or saliva) and no alternative explanation for current clinical condition. Respiratory failure requiring oxygen therapy Has symptoms consistent with COVID-19, and is in non-fibroproliferative stage of disease, as determined by investigator.  Exclusion Criteria:  Respiratory arrest or the need for immediate intubation; Upper airway obstruction; Facial trauma; Inability to cooperate (e.g. agitation or dementia) Inability to give informed consent Participation in another study for COVID19 treatments Deterioration due to other reasons than progressive COVID19 pneumonia per clinical judgment, e.g. pulmonary thromboembolism, heart failure, renal failure etc. Palliative care or expectation that patient will not survive > 72 hours post randomization per clinical judgment of the investigator.