Inclusion Criteria:  Patients with documented progressive keratoconus within one year include any of the following:  A. ≥ 1.00 diopter increase in maximal keratometry (Kmax). B. ≥ 1.00 diopter increase in the manifest cylinder. C. ≥ 0.75 diopter increase in average of Kmax and Kmin (Kmean). D. ≥ 2% decrease in central thickness. E. ≥ 1.50 diopter increase in the central K power from baseline. F. ≥ 1.0 diopter increase in manifest spherical equivalent change (MRSE).  All patients have minimal corneal stromal thickness 400 μm before UVA irradiation.  Exclusion Criteria:  Patients with corneal rings. Advanced keratoconus with corneal scarring. History of herpetic keratitis and severe corneal infection. Pregnancy or breastfeeding. The use of rigid contact lens¬es for more than 4 weeks before the baseline evaluation.