Inclusion Criteria:  The pathological diagnosis was retinoblastoma. According to the IRSs (International retinoblastoma staging system) staging system, the stage was IVB CSF tumor cells on cytology, or radiographic evidence of NM on MRI scans and histologic diagnosis of systemic malignancy needed KPS≥60% Adequate bone marrow and organ function The parents signed the informed consent and were willing to accept the treatment and follow-up.  Exclusion Criteria:  1.Eye diseases other than retinoblastoma The eyes were infected within 30 days before screening There was a history of surgery and / or unhealed wound within 1 month before enrollment . Those who have allergic reaction or allergic history to chemotherapeutic drugs. Infectious diseases requiring oral, intramuscular or intravenous administration. Patients with systemic immune diseases. Active disseminated intravascular coagulation. Abnormal coagulation function. Abnormal bone marrow and organ function. Uncontrollable clinical problems. The researchers believe that those who need to be excluded.