Inclusion Criteria:  Clinical diagnosis of Knee Osteoarthritis Knee Osteoarthritis for at least 6 months painful knee in last month radiographic changes of the knee (Kellgren-Lawrence grade 2 or more) signed informed consent participant can move independently  Exclusion Criteria:  if the participant got knee intra-articular injection 3 months before his entry into the study uncontrolled malignant disease unstable heart disease advanced organ failure disease (NYHA III or IV, or a more than the twofold increase of creatinin, or marked dyspnea) unstable psychiatrist's disease bleeding diathesis anticoagulant use