Inclusion Criteria:  Between the ages of 18 and 80, with any gender; Physical fitness score ECOG 0～1 points; The diagnosis is considered as gastrointestinal pancreatic neuroendocrine tumor or pancreatic ductal adenocarcinoma; There is no obvious contraindication to surgery or biopsy; Uncompensated liver cirrhosis, acute and chronic hepatitis and other diseases; No history of other biliary tract related diseases; Volunteer to participate and sign the informed consent form. -  Exclusion Criteria:  Patients with non-gastrointestinal pancreatic neuroendocrine tumors or pancreatic ductal adenocarcinoma confirmed pathologically; Suffer from other digestive system diseases, such as irritable bowel syndrome, inflammatory bowel disease; Those who have incomplete follow-up data or refuse to accept follow-up; Patients with other malignant tumors or hematological diseases; -