Inclusion Criteria:  Subject is at least 18 years of age.  Subject has a clinical diagnosis of stable AD characterized by at least three of the following four features:  Pruritus Typical morphology and distribution (e.g., flexural lichenification or linearity in adults) Chronic or chronically-relapsing eczematous/atopic dermatitis Personal or family history of atopy (i.e., asthma, allergic rhinitis, AD) Subject has an area of AD (excluding the scalp) covering ≥5% and ≤20% body surface area Subject has an Investigator's Static Global Assessment score of 2 or 3 If the subject is a woman of childbearing potential, she has a negative urine pregnancy test and agrees to use a protocol approved method of birth control for the duration of the study Subject is non-pregnant and non-lactating Subject is in good general health and free of any known disease state or physical condition which, in the investigator's opinion, might impair evaluation of AD or which exposes the subject to an unacceptable risk by study participation Subject is willing and able to follow all study instructions and to attend all study visits Subject is able to comprehend and willing to sign an Informed Consent Form (ICF)  Exclusion Criteria:  Subject has, in the investigator's opinion, spontaneously improving or rapidly deteriorating AD Subject has, in the investigator's opinion, clinically infected AD Subject has any signs or symptoms associated with topical AD therapy (e.g., history of anaphylaxis, hypersensitivity reactions, skin atrophy, striae, pigmentary changes) which, in the investigator's opinion, puts the subject at undue risk by study participation or interfere with the study conduct or evaluations Subject has used any systemic immunosuppressive or immunomodulatory therapy (e.g., etanercept, alefacept, infliximab) with 16 weeks prior to Visit 1 Subject has used any phototherapy (e.g., ultraviolet A, ultraviolet B) for AD within four weeks prior to Visit 1 Subject has used any systemic AD therapy (e.g., systemic corticosteroids [including intranasal and inhaled corticosteroids at doses >2mg of prednisone or equivalent per day], cyclosporine, immunosuppressants/immunomodulators, Janus Kinase inhibitors, methotrexate, cytostatics) within four weeks prior to Visit 1 Subject has used any systemic antibiotics within two weeks prior to Visit 1 Subject has used any topical AD therapy (e.g., corticosteroids, calcineurin inhibitors, topical H1 and H2 antihistamines, topical antimicrobials, other medicated topical agents) on the planned treatment area within one week prior to Visit 1 Subject is currently using antihistamines (e.g., diphenhydramine, terfenadine) UNLESS the subject has been on a stable dose for at four weeks and agrees to continue that dose for the duration of the study Subject has a history of sensitivity to any of the ingredients in the study medications Subject has any concomitant medical condition which, in the investigator's opinion, might put the subject at undue risk by study participation or interfere with the study conduct or evaluations Subject has participated in an investigational drug trial in which administration of an investigational study medication occurred within 30 days prior to Visit 1.