Inclusion Criteria:  Aged: ≥18 years old. Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2. Life expectancy ≥ 3 months. Patients with advanced malignancy tumor who have failed standard treatment or are unable to receive standard treatment or have no effective treatment. Female and male subjects should agree to use an adequate method of contraception starting with signing informed consent form (ICF) through 180 days after the last dose of study. The women of reproductive age who blood/urine results were positivetherapy before the first study drug is administered within less than 7 days.  Exclusion Criteria:  Patients has had or is currently having other malignant tumors within 3 years. Patients have multiple factors that affect their oral medication (such as inability to swallow, chronic diarrhea, and intestinal obstruction). The patient had unmitigated toxic reactions due to any prior treatment. Patients underwent major surgical treatment, open biopsy, or significant traumatic injury within 4 weeks prior to the start of study treatment. Patients have long - term unhealed wounds or fractures. Patients were taking Cytochrome P450 3A4, Cytochrome P450 3A5, Cytochrome P450 2A6, Cytochrome P450 2D6 (CYP3A4, CYP3A5, CYP2A6,CYP2D6) inhibitors or inducers before oral medication. Patients who, in the investigator's judgment, have a comorbidity that seriously endangers patient safety or interferes with study completion, or who are considered unsuitable for inclusion for other reasons.