INCLUSION CRITERIA  Age ≥ 18 years Diabetes mellitus Non-surgical ulcer located distal to the malleoli Wound diameter >4 millimeters Patient-reported wound duration between 6 and 52 weeks  Only one ulcer will be included from each participant. If a patient has more than one eligible ulcer, the largest ulcer is included. In case of equally sized ulcers, the ulcer with the most recent onset is included.  EXCLUSION CRITERIA  Dementia or other reasons that cause inability to give informed consent Malignant disease Current treatment with systemic immunosuppressive drugs.  Exclusion criteria related to the index extremity:  Diagnosed with or awaiting evaluation of suspected acute phase Charcot arthropathy or osteomyelitis Non-palpable pulse in both arteria dorsalis pedis and arteria tibialis posterior accompanied by systolic toe pressure <30 mmHg in the index foot measured within the last 6 months Amputation at midfoot level or proximal to midfoot level Revascularization procedure awaits or has been undertaken within the last 8 weeks or the patient awaits a vascular surgeons' decision on revascularization Gangrene  Exclusion criteria related to the index ulcer  Infection of the ulcer defined according to IWGDF/IDSA (International Working Group on the Diabetic Foot/ Infectious Diseases Society of America system) classification as presence of at least 2 of the following; 1) local swelling or induration; 2) erythema >0.5 to ≤2 cm around the ulcer; 3) local tenderness or pain; 4) local warmth; or 5) purulent discharge. Current antibiotic treatment due to infection of the index ulcer will also be considered as an ongoing infection regardless of presence of clinical signs of infection. Positive probe-to-bone test Exposed joint or tendon The soft tissue layer covering bone or joint is evaluated to be too thin to allow for inforatio technique anywhere in the wound bed. Interdigital ulcer location