Inclusion Criteria:  Age ≥ 13 years Weight > 30 kg HIV-seropositive HIV viral load <400 copies/mL, defined as "virally suppressed," on an efavirenz (EFV) or dolutegravir (DTG)-based ART regimen (see Section 3.6.2) Candidates must meet national criteria for receiving TPT  Exclusion Criteria:  Confirmed or suspected TB disease (evidenced by symptoms and/or clinical exam findings and/or chest radiographic findings suggestive of TB, positive mycobacterial culture or molecular TB testing or currently on TB treatment for active TB disease) Likely to move from the study area during the study period Known recent exposure to a TB case with resistance to isoniazid or rifampicin. Previous treatment for active or latent TB for more than 30 days within the past 2 years On nevirapine, etravirine, rilpivirine, PI-based, or raltegravir-containing ART regimens Known sensitivity or intolerance to isoniazid or rifamycins Suspected acute hepatitis or known chronic or unstable liver disease^ Alanine aminotransferase (ALT) > 3 times the upper limit of normal (ULN) Total bilirubin > 2.5 times the ULN Pregnancy or breastfeeding Females of childbearing potential who are unable or unwilling to use two forms of contraception** On prohibited medications