Inclusion Criteria:  1. No requirement for age and sex 2. Need to meet the diagnosis of at least one IDD (clinically isolated syndrome (CIS)/multiple sclerosis (MS)/neuromyelitis optica spectrum disorder (NMOSD)/MOG antibody-associated disease (MOGAD)/acute disseminated encephalomyelitis (ADEM). 3. Signed informed consent form.  Exclusion Criteria:  Those with severe mental disease unable to cooperate with the examination and/or follow-up. Any patient (or the patient's legal representative) who is unable or refuses to sign informed consent.