Inclusion Criteria:  The subject is willing and parents/guardians are able to give informed consent for participation in the study. Male or Female, aged 3 -18 years. Presenting with wheeze. Able (in the Investigators opinion) and willing to comply with all study requirements  Exclusion Criteria:  Any other significant disease or disorder which, in the opinion of the Investigator, may either put the subjects at risk because of participation in the study, or may influence the result of the study, or the subject's ability to participate in the study.