Inclusion Criteria:  Active workers more than 1 year in selected plants with matched controls from employee of Assiut University.  Exclusion Criteria:  Workers who had been working for less than 1 year in their petrochemical plants Workers with self-reported and/or diagnosed carcinomas, hematological diseases, and/or immune diseases. Workers taking any medicine in the preceding 2 weeks affecting lipid profile & blood picture. Workers unwilling to provide biological samples or doing so in insufficient volume. Workers diagnosed MetS and its components before joing the petrochemical industry. Workers with morbid obesity BMI > 40