Inclusion Criteria:  Recurrence of histologically verified glioblastoma Adequate biopsy to generate enough live cells to allow functional screening Must be ambulatory with an Eastern Cooperative Oncology Group (ECOG) performance status 0-1 Must be 15 to 70 years of age Adequate bone marrow, liver and heart function Must be competent to give consent Signed informed consent and expected cooperation of the patients for the treatment and follow up must be obtained and documented according to International Conference on Harmonization Good Clinical Practice guidelines (ICH GCP), and national/local regulations.  Exclusion Criteria:  Patients taking part in other clinical trials which could make inclusion or follow-up difficult Any reason why, in the opinion of the investigator, the patient should not participate