Inclusion Criteria:  Age 18-80 years old, both gender Confirmed diagnosis of stage III hepatocellular carcinoma(HCC) Fulfill the criteria of surgery No other severe comorbidity Eastern Cooperative Oncology Group score(ECOG) 0-2 Expected survival > 3months Informed consent obtained.  Exclusion Criteria:  Received chemoradiotherapy or other antineoplastic drugs Severe cirrhosis with Child-Pugh score >10 Total bilirubin > 1.5 times upper limit, AST or ALT > 2times upper limit, indocyanine green retention rate after 15 min(ICG15) >=40%; Not fulfill the surgery criteria Received major surgery within 1month History of other tumor Participate other clinical trial within 1month Drug or alcohol abuse, AIDS Uncontrollable epileptic seizure or cognitive disorder Severe allergy Other unsuitable conditions.