Inclusion Criteria:  Newborns presenting with probable genetic conditions inpatient on the NICU. These may include (but is not limited to) those with unexplained hypotonia, seizures, metabolic disorders, disorders of sex development, interstitial lung disease, immunodeficiency or multiple congenital anomalies.  Exclusion Criteria:  Presence of a likely nongenetic explanation for the phenotype (e.g., perinatal asphyxia explained by uterine rupture or placental pathology; Clinical features pathognomonic for a recognizable chromosomal abnormality, such as trisomy 21; Associations already known to have low genetic diagnostic yield, including VATER/VACTERL association and OEIS complex; Infants who die before enrollment; Known family history of genetic disease that is plausibly the cause of the infant's illness; - Those with a prenatal genetic diagnosis.