Inclusion Criteria:  Darvadstrocel cohort  1. Participants will be included in the darvadstrocel cohort if they have at least one record of prescription/dispensation/administration of darvadstrocel at some point during the study period.  Comparator cohort  A comparator cohort of controls (matched control cohort) will be composed of participants with CD and PAF randomly selected from a pool of eligible participants with no history of administration of darvadstrocel. Has any other management of CPAF different to darvadstrocel, from no treatment to any other treatment.  Exclusion Criteria:  Has less than 12 months of uninterrupted data within country-specific data source prior to index date. Has not meet quality indicators for country-specific data source (if applicable). Has diagnosis of cancer prior to index date. This will minimise the misclassification of prevalent or metastatic cancer as incident cases for the analysis of the study objectives. Has diagnosis of ulcerative colitis at any point during the study period and medical history period. This will avoid potential ascertainment bias as there is currently no gold standard for differential diagnosis in IBD. Approximately 5 percent (%) to 15% of cases do not meet strict criteria for either ulcerative colitis (UC) or CD and in up to 14% of participants classified as UC and CD, the diagnosis changes over time. Has record of proctectomy or colectomy prior to index date. Proctectomy and colectomy are considered "last chance" surgery options for anal fistulas or other complications of CD. These participants are not the target population for darvadstrocel. They would not be eligible for darvadstrocel administration and loss of their gastrointestinal tract would affect the risk of colorectal cancer; the most common cancer associated with CD.