Inclusion Criteria:  Female patients aged 18-70 years. Diagnosed with locally advanced (T2-3, N2-3, M0 or T4a-c, any N, M0), inflammatory (T4d, any N, M0) or operable (T2-3, N0-1, M0), invasive breast cancer. Primary tumor > 2 cm in diameter. HER2 positive breast cancer confirmed (Tumors must be IHC 3+ or FISH/CISH + for IHC 2+ tumors). Baseline LVEF ≥ 55% measured by echocardiography. Performance status ECOG ≤ 1 Signed informed consent.  Exclusion Criteria:  Metastatic disease (Stage IV) or bilateral breast cancer. Previous anticancer therapy or radiotherapy for any malignancy. Other malignancy, except for carcinoma in situ of the cervix or basal cell carcinoma. Received any investigational treatment within 4 weeks of study start. At least 4 weeks since major surgery. Uncontrolled hypertension (systolic > 150 and/or diastolic > 100), unstable angina, CHF of any NYHA classification, serious cardiac arrhythmia requiring treatment, history of myocardial infarction within 6 months of enrollment.  Hematological, biochemical and organ dysfunction:  Inadequate bone marrow function: Absolute Neutrophil Count (ANC) < 1500 cells/ µL, Platelet count < 100,000 cells/ µL and Hb < 9 g/dL). Impaired liver function: serum [total] bilirubin > 1.25 x ULN, AST/ALT > 1. 5 x ULN with ALP > 2.5 x ULN Inadequate renal function: serum creatinine > 1.5 x ULN. Dyspnea at rest or other diseases which require continuous oxygen therapy. Severe uncontrolled systemic disease (e.g., clinically significant cardiovascular, pulmonary, metabolic, etc). Current chronic daily treatment with corticosteroids (dose of ≥10 mg Oral prednisolone, or equivalent [excluding inhaled steroids]) Subjects with known infection with HIV, HBV, and HCV. Known hypersensitivity to any of the study drugs or excipients. Pregnant and/or lactating women or subjects with reproductive potential not willing to use effective methods of contraception. Subjects assessed by the investigator to be unable or unwilling to comply with the requirements of the protocol (e.g.: physical, psychological and mental problems)