Inclusion Criteria:  Aged from 18-75 years. HCC diagnosis was confirmed by pathological examination and those who did not receive anti-tumor treatment (anti-tumor treatment including but not limited to: local ablation therapy, TACE, radiation therapy, chemotherapy, targeted drug therapy, immunotherapy, and etc.) Underwent curative resection for HCC with high risk of tumor recurrence, which was defined by Shanghai Score ≥ 4.922 (Sun, et al. Chin Med J (Engl) 2017) Child-Pugh class: A or B7 The ECOG Performance Status: 0-1 points The expected survival time ≥ 6 months No disease recurrence 4-6 weeks after surgery as evaluated by abdominal contrast-enhanced CT/MRI and chest CT. Adequate organs function Complete blood counting HB ≥ 90 g/L ANC ≥ 1.5×10^9 /L PLT ≥ 75×10^9/L Blood biochemistry ALB ≥ 28 g/L ALT and AST< 5×ULN TBIL ≤ 2×ULN Serum creatinine ≤ 1×ULN Women of childbearing age must have pregnancy tests within 7 days prior to admission, and the results are negative and are willing to use appropriate methods of contraception at 8 weeks after the trial and at the end of the trial. For men, surgical sterilization should be applied, or consent to use appropriate methods of contraception 8 weeks after the trial and at the end of the trial. Subjects voluntarily participated in the study, signed informed consent, good compliance in drug therapy and followed up.  Exclusion Criteria:  Cholangiocarcinoma, the combination of cholangiocarcinoma of HCC, or fibrolamellar HCC diagnosed by pathology examination. Past or current diagnosed with other malignancy, except skin basal cell carcinoma and cervical carcinoma in situ. Those treated with liver or other organ transplantation or willing to undergo liver transplantation. The conditions not suitable for oral medications, including difficulty swallowing, chronic diarrhoea, or bowel obstruction.  Vascular events within 6 months, including stroke and transient ischemic attack  , deep venous thrombosis or pulmonary artery embolism.  Alimentary tract hemorrhage or high risk of alimentary tract hemorrhage due to esophageal varices, active ulcerative lesions or ulcerative colitis; or fecal occult blood test ≥ ++, or for those with fecal occult blood test (+), gastroscopy is required. Abnormal coagulation function (international normalized ratio > 2, prothrombin time > 16 s, thrombin time >21s, activated partial thromboplastin time > 21 s, or fibrinogen < 2 g/L); or other conditions with bleeding tendency or undergoing thrombolysis or anticoagulant therapy. Other severe or uncontrolled comorbidities: hypertension and the blood pressure was not well managed by medications (systolic pressure ≥ 150 mmHg or diastolic pressure ≥ 90 mmHg); level 2 or higher myocardial ischemia or myocardial infarction, uncontrolled arrhythmia (including QTc interval ≥ 480 ms); level 1 heart dysfunction; or LVEF < 50%. active or uncontrolled infection. uncontrolled diabetes (fasting blood glucose > 10 mmol/L). Urinary protein ≥ ++ or 24 hours urine protein > 1 g. Unhealed wounds, ulcer, or bone fracture. Those with mental illness or a history of psychotropic substance abuse; HIV infection. Other conditions that the investigators considered that not suitable for trial inclusion.