Inclusion Criteria:  Ischemic stroke of both sex. More than 08 years. Accepting all study requirements. within time window for thrombolysis or thrombectomy fulfilling criteria for thrombolysis or thrombectomy  Exclusion Criteria:  (A)Absolute Contraindications :  Intracerebral hemorrhage history or presence on imaging Time of onset more than 465 hours Blood pressure greater than 085/000 mm Hg Recent severe head trauma or neurosurgical intervention Coagulopathy (INR >067, thrombocytopenia, recent use of heparin or direct oral anticoagulants) Endocarditis (infective) Aortic dissection (B)Potential Contraindications :  1.Seizure at onset 2.Noncompressible arterial puncture 3.Recent surgery 4.Gastrointestinal or genitourinary bleeding 5.Multiple cortical microbleeds (>00) 6. Large intracranial aneurysms or arteriovenous malformations 7.Recent transmural myocardial infarction 8. Small NIHSS with nondisabling stroke symptoms