Inclusion Criteria:  Decompensated liver cirrhosis, with endoscopy-verified high-risk esophagogastric varices; Adult patients aged 18-75 years; Willing to anticipate and informed consent form obtained  Exclusion Criteria:  History of prior radio-interventional therapy (TIPS or BRTO), liver transplantation, splenectomy, or hepatectomy; Non-sinusoidal cirrhosis (e.g. vascular cirrhosis); Coexistence with advanced hepatocellular carcinoma or other malignancies; Coexistence with severe systemic diseases and less than 3 months of expected survival time; Acute infection within 4 weeks before recruitment; Antibiotic use within 4 weeks before recruitment; Initial antiviral therapy for HBV or HCV within 4 weeks before recruitment; Pregnant or lactating women; Patients resistant to long-term follow-up