Inclusion Criteria:  ≥72 years old Either have a diagnosis of dementia or have a severe cognitive impairment as judged by the GP Are permanently living at the nursing home  Are prescribed at least one antidepressant with the following ATC-codes  Selective serotonin reuptake inhibitors (SSRIs): N06AB10 (Escitalopram); N06AB04 (Citalopram); N06AB08 (Fluvoxamin); N06AB03 (Fluoxetin); N06AB05 (Paroxetin); N06AB06 (Sertralin); Serotonin-Norepinephrine Reuptake inhibitors (SNRIs): N06AX21 (Duloxetin); N06AX16 (Venlafaxin); Tricyclic antidepressants (TCAs): N06AA09 (Amitriptylin); N06AA04 (Clomipramin); N06AA02 (Imipramin); N06AA10 (Nortriptylin); (Dosulepin); N06AA17 Noradrenergic and specific serotonergic antidepressants (NaSSAs) / Atypical antidepressants N06AX03 (Mianserin); N06AX11 (Mirtazapin); Monoamine oxidase inhibitors (MAOIs):N06AF01 (Isocarboxazid); Noradrenaline reuptake inhibitor (NARI): N06AX18 (Reboxetin); Other antidepressant with effect on the serotonin-system: N06AX26 (Vortioxetin); Melatonin agonists: N06AX22 (Agomelatin);  Exclusion Criteria:  They are under treatment of a psychiatrist. They are enrolled in another psychopharmacological trial There is a suspicion of a current clinical, major depression or suicidal behavior and intentions. Receiving end-of-life care