Inclusion Criteria:  a) HIV-negative cisgender female, b) age ≥ 18 years, c) speaks/reads English d) reporting past 30 day non-prescription injection drug use and any of the following HIV risk behaviors based on the 2021 PrEP prescribing guidelines: 1 or more HIV-positive sex partners or partners of unknown HIV status; syphilis or gonorrhea in last 6 months; syringe sharing; has not taken PrEP within 30 days.  Exclusion Criteria:  a) Unable to provide informed consent; b); unwilling or unable to return to the SSP daily for the next 90 days; c) unwilling to provide specimen for PrEP-related clinical monitoring and adherence monitoring.