Inclusion Criteria:  Patient Inclusion Criteria : Adult patients who are < 80 years old with a first diagnosis of colon cancer, regardless of TNM stage to undergo a scheduled excision surgery (laparoscopic colectomy or laparoscopy) and post-operative chemotherapy treatment with WHO stage < 1 at visits V1 and V2 having given their written consent living close to the participating center (<50 km) ability to understand instructions with the consent of the surgeon and oncologist to the practice of physical activity having no medical contraindication to the physical activity program, in particular ostomy  Criteria for inclusion of healthy subjects :  Adult who is < 80 years old matched by gender, age and BMI to a patient with WHO stage < 1 at visits V1 and V2 no medical contraindications to the program having given written consent  Exclusion Criteria:  Criteria for exclusion of patients and healthy subjects : Protected Adult Person not affiliated to national health insurance Pregnant or breastfeeding woman hypersensitivity to lidocaine uncontrolled hypertension Suffers from unstable diabetes of any type Suffers from heart disease. Pre-surgical VO2 test will confirm authorization. Affected by any condition likely to complicate the performance of physical activity (neurological, psychiatric, neuromuscular disorders, severe osteoporosis) Person who has been regularly physically active in the last 2 months (strength and/or aerobic training) ≥ 150 min/week  Patient-specific exclusion criteria  Patient with rectal cancer or other evolving cancer Presence of an ostomy (complicates the practice of physical activity)  Exclusion criteria specific to healthy subjects  - Subject has had cancer in the last 5 years  Criteria for exclusion of patients and healthy subjects for biopsy:  Person with keloidosis Person with bleeding disorders, and/or on anticoagulant and antiaggregant medication