Inclusion Criteria:  Subject must have the ability to understand and provide written informed consent Subject must be ≥18 years of age Subject must be willing and able to comply with study procedures and duration Male or female of any race Baseline SpO2 ≥85% At least 3 subjects (10% of a total 30 subjects) will have a history of smoking  Exclusion Criteria:  Subjects who meet any of the following criteria will be excluded from the study:  Subjects who refuse or are unable to provide to sign an informed written consent for study Subject is evaluated by the Investigator and found to be medically unsuitable for participation in this study Compromised circulation, injury, or physical malformation of fingers, toes, hands, ears or forehead/skull or other sensor sites which would limit the ability to test sites needed for the study. Tattoo in the optical path which would limit the ability to test sites needed for the study. (Note: Certain malformations may still allow subjects to participate if the condition is noted and would not affect the particular sites utilized.)  Subjects with known respiratory conditions such as:  uncontrolled / severe asthma, flu, pneumonia / bronchitis, shortness of breath / respiratory distress, respiratory or lung surgery, Severe COPD  Subjects with self-reported heart or cardiovascular conditions such as:  high blood pressure: systolic >160 mmHg or diastolic >100 mmHg on 3 consecutive readings (reviewed during health screen) have had cardiovascular surgery chest pain (angina) heart rhythms other than a normal sinus rhythm or with respiratory sinus arrhythmia (occasional PVCs is acceptable, less than two a minute) previous heart attack blocked artery unexplained shortness of breath congestive heart failure (CHF) history of stroke transient ischemic attack carotid artery disease myocardial ischemia myocardial infarction cardiomyopathy  Self-reported health conditions as identified in the Health Assessment Form  uncontrolled thyroid disease, kidney disease / chronic renal impairment, history of seizures (except childhood febrile seizures), epilepsy, history of unexplained syncope, recent history of frequent migraine headaches, recent head injury within the last 2 months, Cancer / chemotherapy Subjects with severe contact allergies to standard adhesives, latex or other materials found in pulse oximetry sensors, ECG electrodes, or other medical sensors (self-reported) Other known health condition, should be considered upon disclosure in health assessment form