Inclusion Criteria:  patients with fixed orthodontic appliances in at least one arch for at least 3-6 months, visible plaque around the bracket bases of at least 6 teeth repeated oral hygiene instructions have been given during the orthodontic treatment  Exclusion Criteria:  clinically visible active caries lesions and/or periodontitis significant oral soft tissue pathology based on a visual examination history of allergy or significant adverse events following use of oral hygiene products such as toothpastes, mouth rinses, breath mints, lozenges, or chewing gum or their ingredients history of allergies to ingredients in the test product, including allergy against enzymes history of common food allergies, such as peanuts, tree nuts, milk, eggs, shellfish, fish, wheat, soybeans self-reported serious medical conditions, pregnancy or nursing acute sinusitis or severe oral-pharyngeal infections