Inclusion Criteria:  Adult patient >18 years Patient with acute leukemia eligible to receive intensive chemotherapy (induction phase) with predictable deep bone marrow aplasia (polynuclear neutrophils <500mm3 for more than 8 days) requiring prolonged hospitalization with room confinement. Patient having signed the informed consent to participate in the study  Exclusion Criteria:  Patient with disabilities or contraindications (significant cognitive or psychiatric disorders, significant cardiac or pulmonary pathology, neurological, joint, orthopedic or medical condition, etc.) following an exercise therapy program and carrying out follow-up defined by the protocol and in particular the physical performance tests. Active bleeding, acute thrombosis, ischemia, hemodynamic instability or uncontrolled pain No understanding of the French language Pregnant women, parturients and nursing mothers Persons deprived of their liberty by judicial or administrative decision People under duress psychiatric care Persons subject to legal protection Persons unable to express their consent Person not affiliated to a health insurance scheme or not beneficiary of a social security scheme.