Inclusion Criteria:  Patients aged 18-70 with H. pylori infection. Patients Allergic to Penicillin.  Exclusion Criteria:  Patients with previous H. pylori eradication therapy. Patients treated with Histamine-receptor antagonist, proton pump inhibitor, bismuth and antibiotics in the previous 4 weeks. Patients with gastrectomy, acute gastrointestinal bleeding and advanced gastric cancer. Patients with known or suspected allergy to study medications. Currently pregnant or lactating. Inability to provide informed consent