Inclusion Criteria:  Patient with Parkinson's disease age< 70 years Underwent bilateral STN-DBS or not Having complete medical history and clinical follow up All MRI examination performed according to study protocol Imaging data can be processed Signed informed consent obtained from the patient or patient's legally authorized representative;  Exclusion Criteria:  Parkinson-plus syndrome or secondary parkinsonism Patients with severe mental disorders such as psychosis, liver and kidney dysfunction, poor blood pressure or blood glucose control, severe depression and substance abuse, low IQ, and acute phase of severe stroke with definite limb dysfunction should also be excluded.