Inclusion Criteria:  The subject is 18 years or older. The subject can be implanted with the assigned craniotomy closure system according to its Instructions for Use. At least one post-operative medical image (CT scan or Magnetic Resonance image) is planned to be performed. Life expectancy higher than 6 months. The subject is willing to give his/her informed consent and to comply with the required follow-up.  Exclusion Criteria:  The subject presents any of the contraindications of the assigned craniotomy closure system. Orbitozygomatic or mastoid craniotomies. Posterior fossa (skull base) surgeries. Combined used of craniotomy systems (plates and clamps). The subject is currently participating in an investigational drug or device study.