Inclusion Criteria:  1- Adult patients (aged 18 and over) with bilateral nasal polyps confirmed by nasal endoscopy and CT scan.  Exclusion Criteria:  CRS without nasal polyps. Unilateral nasal polyps. Pregnant and lactating women. Patients younger than 18 years old. Subjects with known allergic reaction to steroids or tetracyclines, hypertension, diabetes (type 1 and 2), glaucoma, tuberculosis, herpes infection are excluded. If any major complications to the drugs in use appeared in process.