Inclusion Criteria  Have skeletal Cl III malocclusion Wisdom teeth are absent or extracted at least 6 months before the surgery Need of orthognathic surgery through Le Fort I osteotomy of the maxilla and bilateral sagittal split osteotomies (BSSO) of the mandible. Undergo fixed orthodontic treatment before and after the orthognathic surgery Have available orthopantomograms with adequate quality Have healthy periodontal tissue without inflammation or bleeding before and after the surgery. Maintain the same medication protocol during and after the surgery.  Exclusion Criteria:  ongoing use of regular medication smoking known penicillin allergy, any immune disorder, musculoskeletal diseases, syndromes, cleft lip-palate, systemic diseases affecting root resorption, periodontal and gingival disorders, missing teeth among upper or lower incisors, poor oral hygiene.