Inclusion Criteria:  Age ≥ 18 years Ability to give informed consent Documented NVAF (paroxysmal, persistent, or permanent) CHA2DS2VASc risk score ≥2 Chronic kidney disease KDOQI stage 5 (eGFR <15 ml/min/1.73m2) with or without hemodialysis  Exclusion Criteria:  Absolute contraindication to aspirin and/or clopidogrel Comorbidities other than AF requiring chronic (N)OAC therapy e.g. mechanical heart valve prosthesis Present LAA thrombus Mobile aortic atheroma Age ≤18 years Patients presenting with pregnancy Patients without informed consent Participation in another trial Expected life expectancy <2 years