Inclusion Criteria:  Active MNV secondary to nAMD, going along with clinically significant vision loss Patients aged 50 years or older of all sexes Presence of IRF and/or SRF and/or subretinal hyperreflective material affecting the central subfield of the study eye on OCT signed informed consent for this study prior to the screening visit If possible: availability of a smartphone and willingness to perform self-testing with the Alleye app (soft criteria)  Exclusion Criteria:  Any other cause of macular oedema Structural damage to the macula precluding a visual potential Optical media opacities not allowing an accurate performance of the protocol examinations Any intraocular surgery within three months prior to inclusion and history of any vitreoretinal surgery Advanced diabetic retinopathy potentially requiring any treatment within six months following inclusion or history of vitreal haemorrhage Presence of vitreoretinal traction or tractive epiretinal membrane affecting the fovea History of IVT with anti-VEGF or corticosteroids at any time in the study eye Inability to follow the procedures of the study, e.g., due to language problems, psychological disorders, dementia, etc. Significantly worse functional prognosis in the other eye or only eye Women of childbearing potential not willing to use an effective method of contraception during treatment and until at least 3 months after the last treatment Pregnant or lactating women Any systemic auto-inflammatory and auto-immune disease requiring treatment Treatment with high-dose corticosteroids (Prednisone equivalent >5mg/day), immunosuppressive or immunomodulatory or anti-proliferative agents for any reason Inability or contraindications to undergo the investigated intervention