Inclusion Criteria:  -  A subject must satisfy all of the following criteria to be considered for inclusion in the study:  Histologically or cytologically confirmed advanced or metastatic non-squamous non-small cell lung cancer. Failed with prior EGFR-TKIs treatments. Measurable disease, as defined by RECIST v1.1 The Eastern Cancer Cooperative Group (ECOG) performance status of 0 or 1 Life expectancy ≥ 3 months Adequate hematologic and end-organ function as defined in the protocol  Exclusion Criteria:  -  A subject who meets any of the following criteria will be excluded from study entry:  Histologically or cytologically confirmed mixed SCLC and NSCLC. Symptomatic, untreated or active central nervous system metastases. Systemic therapy with immunosuppressive agents within 2 weeks prior to initiation of study treatment With any active autoimmune disease or history of autoimmune disease. Inadequately controlled hypertension. Tumour infiltration into the great vessels on imaging. History of haemoptysis ≥2.5ml per episode within 1 month prior to initiation of study treatment. Uncontrolled tumour-related pain. Patients with active hepatitis B or hepatitis C Severe infections within 4 weeks prior to initiation of study treatment. Active tuberculosis within one year prior to initiation of study treatment.