Inclusion Criteria:  • Systemically healthy individuals  Presence of at least 20 teeth excluding third molars. PH individuals defined as <10% bleeding sites with probing depths ≤3mm. Periodontitis criteria:  Stage III periodontitis with ≥30% teeth involved and bleeding on probing with >30% sites involved.  Exclusion Criteria:  Confirmed or assumed allergies or hypersensitivity reactions to amoxicillin and/or metronidazole. Alcohol consumers. History of systemic medication affecting the periodontal conditions, e.g. steroids, immune suppressants, antibiotics, anti-inﬂammatory drugs, statins, lipid lowering drugs, anti-convulsants, anti-coagulants, anti-hypertensives or any other host modulatory drugs within 6 months of commencing the study. Had received any periodontal treatment in the previous 12 months. Undergoing or require an extensive dental or orthodontic treatment. Pregnant or breastfeeding women. Current or former users of tobacco in any form.