Inclusion Criteria:  Enhanced brain MRI with or without cranial CT confirms a diagnosis of tumor in the anterior skull base, the middle cranial fossa, or the posterior cranial fossa. Structural images, DTI sequences and 3D-CISS sequences confirm that the tumor is adjacent to the cranial nerve or the cranial nerve will be exposed during the neurological surgery. The body weight is within ±20% of standard body weight [0.7×(height cm-80)]kg; The preoperative laboratory examination parameters of heart, lung, liver, kidney and blood are all in the normal range; Be able to understand the potential risks and benefits of the clinical trial, and sign a written informed consent.  Exclusion Criteria:  Preoperative hepatorenal insufficiency: ALT or AST increased ≥ 2 times than the upper limit of normal range; serum creatinine > 2.0 mg/ dL (177 μmol/L) or glomerular filtration rate > 30 ml/min×1.73 m2; Positive reaction in the allergy test, or allergic constitution (such as allergic to two or more foods/drugs, or known to be allergic to protein or to this polypeptide); Preoperative imaging data (enhanced MRI) are incomplete; Serious primary diseases involving important organs; Mentally or physically disabled patients; Alcohol abuse or long-term medication may affect the drug metabolism; According to the judgment of the investigator, the potential intolerance to the drug (such as weak or severe malnutrition); Primary or secondary cranial nerve dysfunction, such as facial paralysis, hearing loss caused by otitis media, etc. Female patients undergoing neurosurgery during pregnancy or lactation.