Inclusion Criteria:  Healthy adults 18-55 years Males or non-pregnant, non-lactating females Body mass index (BMI) between 18 and 32.0 kg/m2 and total body weight >50 kg (110 lbs) Normal blood pressure Normal lab tests  Exclusion Criteria:  Current cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, autoimmune, hematologic, neoplastic, or neurological disorder History of severe allergic or anaphylactic reaction Abnormal ECG or history of clinically significant abnormal rhythm disorder Positive alcohol, drug, or tobacco use/test