Inclusion Criteria:  - 1. Healthy pregnant women. 2. Age (18 - 35 years old). 3. Women with BMI (_> 30 kg/m2).  4. A living singleton pregnancy. Gestational age (24- 27 weeks).(recruitment time)  Exclusion Criteria:  - 1. Multiple gestations. 2. Women with diabetes 3. pre-pregnancy cardiovascular disease, chronic hypertensive, and pregnancy-induced hypertension; blood pressure _> 140/90.  4. Women with hepatic, renal diseases or coagulopathy 5. Women with peptic ulcer.