Inclusion Criteria:  patients 18 years or older patients provided written informed consent patients after kidney transplantation functioning kidney allograft, at least after 180 days after last transplantation estimated glomerular filtration rate above 20 ml/min/1.73m^2 detection of DSA  Exclusion Criteria:  patients younger than 18 years patients unable or did not provide written informed consent pregnant or breastfeeding persons patients with increased bleeding risk patients with multi-organ transplantation patients who underwent kidney allograft biopsy after first detection of DSA biopsy-proven antibody-mediated rejection participation in another interventional clinical trial