Inclusion Criteria:  all cases of endometrial biopsies and hystrectomy specimens diagnosed as endometrial hyperplasia and/or primary endometrial adenocarcinoma. all cases of normal endometrium obtained from hystrectomy specimens due to other pathological conditions as prolapsed uteri, uterine leiomyoma and adenomyosis.  Exclusion Criteria:  autolysed samples, very tiny specimens cervical tissues and specimens with histological picture of endometritis.