Inclusion Criteria:  Adult male or female subject; Glioma or brain metastasis operated on in our institution, histologically confirmed (WHO classification 2016); Subject with a frozen tumour sample < 5 years old; Subject for whom all clinico-radiological data are available; Subject affiliated to a health insurance scheme; Subject who has been informed of the research and who has not indicated his opposition to the use of his medical data and who has signed a consent for the use of his tumour sample.  Exclusion Criteria:  Patient under legal protection, guardianship or deprived of liberty by judicial or administrative decision Biological samples not available and/or in insufficient quantity for analysis