Inclusion Criteria:  all male and female patients older than 18 years who have COPD, ILD or are smokers and non smokers without pulmonary diseases. right heart catheterization performed due to to suspected pulmonary hypertension and further clinical investigation like echocardiography, lung function testing, 6-minute walk test, laboratory testing and blood gas analysis. written informed consent  Exclusion Criteria:  contraindication for lung function testing acute life-threatening disease (including acute myocardiac infarction, pulmonary embolism, large aortic aneurysma, pneumothorax, opthalmic, brain, abdominal or thoracic surgery within the last 4 weeks, hemoptysis).