Inclusion Criteria:  Healthy, adult, male or female (of non-childbearing potential), at the screening visit Body mass index between 18 and 32 kilograms/m^2 inclusive, at screening Healthy as determined by pre-study medical history, physical examination, vital signs, complete neurological examination and 12-lead ECG Clinical laboratory test results clinically acceptable at screening and check-in Non-smokers or ex-smokers (must have ceased smoking and stopped using nicotine containing products >3 months prior to the first dosing) based on participant self-reporting  Exclusion Criteria:  Participants who have a clinically relevant history or presence of respiratory, gastrointestinal, renal, hepatic, hematological, lymphatic, neurological, cardiovascular, psychiatric, musculoskeletal, genitourinary, immunological, dermatological, rheumatological, endocrine, connective tissue diseases or disorders Have a clinically relevant surgical history in the opinion of the principal investigator or designee Have a history of relevant atopy or hypersensitivity to the study drugs or related compounds (e.g., allergy to itraconazole or other azole antifungals History or presence of alcohol or drug abuse within the past 2 years prior to the first dosing  Note: This is not an exhaustive list of criterias.