Inclusion Criteria:  Type 2 diabetes HbA1c ≥7.0%  Prior CVD cohort: age ≥50 and ≥1 of the following criteria.  Prior MI Prior stroke or TIA Prior coronary, carotid or peripheral arterial revascularization N50% stenosis of coronary, carotid, or lower extremity arteries History of symptomatic CHD documented by Positive exercise stress test or any cardiac imaging or Unstable angina with ECG changes Asymptomatic cardiac ischemia Documented by positive nuclear imaging test, exercise test or dobutamine stress echo Chronic heart failure NYHA class II-III Chronic renal failure, eGFR <60 mL/min per 1.73m2 MDRD eGFR <60 mL/min per Cockcroft-Gault formula  No Prior CVD group: Age ≥60 y and ≥1 of the following criteria.  Microalbuminuria or proteinuria Hypertension and left ventricular hypertrophy by ECG or imaging Left ventricular systolic or diastolic dysfunction by imaging Ankle-brachial index b0.9  Exclusion Criteria:  Type 1 diabetes other type diabetes Calcitonin ≥50 ng/L Use of a GLP-1 receptor agonist (exenatide, liraglutide or other) or pramlintide or any DPP-4 inhibitor within the 3 months prior to screening Use of insulin other than human NPH insulin or long-acting insulin analogue or premixed insulin within 3 months prior to screening. Shortterm use of other insulin during this period in connection with intercurrent illness is allowed, at Investigators discretion Acute decompensation of glycemic control An acute coronary or cerebrovascular event in the previous 14 d Currently planned coronary, carotid, or peripheral artery revascularization Chronic heart failure (NYHA class IV) Current continuous renal replacement therapy End-stage liver disease History of solid organ transplant or awaiting solid organ transplant Malignant neoplasm Family or personal history of multiple endocrine neoplasia type 2 (MEN2) or familial medullary thyroid carcinoma (FMTC) Personal history of non-familial medullary thyroid carcinoma