Inclusion Criteria:  1. Histologically or cytologically confirmed prostate carcinoma. 2.Eastern Cooperative Oncology Group (ECOG) performance status score of 0 to 2; Life expectancy ≥12 weeks.  3.Testosterone levels < 50 ng/dL. 4. Has received ≥1 previous regimens for metastatic castration-resistant prostate cancer.  5.Male subjects should agree to use an adequate method of contraception starting with signing ICF through 6 months after the last dose of study.  6.Understood and signed an informed consent form.  Exclusion Criteria:  -1.Has symptomatic brain metastases or control of symptoms < 1 month. 2.Has other malignancies within 3 years. 3.Has used second-generation androgen receptor antagonists. 4. Abnormal liver function. 5. Abnormal renal function. 6. Has received any other investigational drug within 30 days weeks before first dose.  7. According to the judgement of the researchers, there are other factors that subjects are not suitable for the study.