Disease: Leukoplakia
Symptoms: Leukoplakia usually occurs on your gums, the insides of your cheeks, the bottom of your mouth — beneath the tongue — and, sometimes, your tongue. It isn't usually painful and may go unnoticed for a while. Leukoplakia may appear:  White or grayish in patches that can't be wiped away Irregular or flat-textured Thickened or hardened in areas Along with raised, red lesions (speckled leukoplakia or erythroplakia), which are more likely to show precancerous changes  Hairy leukoplakia Hairy leukoplakia causes fuzzy, white patches that resemble folds or ridges, usually on the sides of your tongue. It's often mistaken for oral thrush, an infection marked by creamy white patches that can be wiped away, which is also common in people with a weakened immune system. When to see a doctor Even though leukoplakia doesn't usually cause discomfort, sometimes it can indicate a more serious condition. See your dentist or primary care professional if you have any of the following:  White plaques or sores in your mouth that don't heal on their own within two weeks      Lumps or white, red or dark patches in your mouth      Persistent changes in the tissues of your mouth      Ear pain when swallowing      Progressive reduction in the ability to open your jaw