Disease: Adrenal Cancer
Symptoms: Signs and symptoms of adrenal cancer include:  Weight gain Muscle weakness Pink or purple stretch marks on the skin Hormone changes in women that might cause excess facial hair, hair loss on the head and irregular periods Hormone changes in men that might cause enlarged breast tissue and shrinking testicles Nausea Vomiting Abdominal bloating Back pain Fever Loss of appetite Loss of weight without trying  Causes It's not clear what causes adrenal cancer. Adrenal cancer forms when something creates changes (mutations) in the DNA of an adrenal gland cell. A cell's DNA contains the instructions that tell a cell what to do. The mutations can tell the cell to multiply uncontrollably and to continue living when healthy cells would die. When this happens, the abnormal cells accumulate and form a tumor. The tumor cells can break away and spread (metastasize) to other parts of the body. Risk factors Adrenal cancer happens more often in people with inherited syndromes that increase the risk of certain cancers. These inherited syndromes include:  Beckwith-Wiedemann syndrome Carney complex Li-Fraumeni syndrome Lynch syndrome Multiple endocrine neoplasia, type 1 (MEN 1)  By Mayo Clinic Staff By Mayo Clinic Staff  Adrenal cancer care at Mayo Clinic