Correlación del perfil genético con la enfermedad mínima residual al día 15 y al final de la inducción en niños menores de 18 años con diagnóstico de leucemia linfoide aguda de precursores b, en un centro de referencia
Autor: Flechas Afanador, Jessica
Asesor: Linares Ballesteros, Teresa Adriana
Fecha: 2019
Programa: Bogotá - Medicina - Especialidad en Oncohematología Pediátrica
Facultad: Facultad de Medicina

Resumen: Background.  It is recommended to assess cytogenetic testing in children with ALL. The prevalence of these results in colombian population is unknown, as well as the association of cytogenetic findings with Minimal Residual Disease (MRD).
Objective. To correlate cytogenetic results with minimal residual disease (MRD) at day 15 and at the end of induction (day 33) in children &lt;18 years old with B-lineage ALL. 
Methods. An observational descriptive study of patients &gt;1 and &lt;18 years with newly diagnosed B-lineage ALL, enrolled from January 2015 to July 2019 in a reference center in Colombia.
Results. 254 patients were included. 178(70.1%) had normal cytogenetic results. Alterations were found in 46(18%). Abnormal karyotype was found in 25(9.8%), the most common alteration was hyperdiploidy. T(9:22) was detected in 8(3.1%), t(12:21) in 26(10.2%) and t(4:11) in 1(0.4%). Multiparameter Flow cytometry MRD at day 15 in 70 patients (10.2%) was 0.1%, 105 (41.3%) between 0.1% and &lt;10% and 73 (28%) &gt;10%. On day 33, 192 (75.5%) had MRD &lt;0,01%.  16/73 (21.9%). MRD at day 15 &gt;10%, was found as flows: t(12:21), t(9:22) and t(4:11) was seen in 10,9%, 9,5% and 1,36% respectively. T(9;22) has an OR 18,9 (IC95% 2,27-156) and p 0,001 in MRD &gt;10% at day 15, but was no statistically significant by day 33.