Evaluation of Diagnostic and Prognostic Molecular Markers in Adrenal Neoplasm
Conditions: Adrenal Gland Neoplasms
Sponsor: National Cancer Institute (NCI)

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FNA/Tissue sample
Department of pathology for 
cytologic examination
Endocrine Oncology Laboratory
1.
Slide smear for immunohistochemistry (if enough 
cells)
2.
Storage in RNAlater ® -80RCfor molecular analysis
RNA & DNA extraction
1. Quantitative RT PCR for candidate markers 
(see Table 1 and 2)
Analysis
1. ROC curve (diagnostic accuracy)
2. Area under the ROC curve (diagnostic 
accuracy)
3. Univariate & multivariate analysis 
(prognostic accuracy)
Figure 1. Flow diagram of specimen collection and analysis.
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