Differentiating Unipolar and Bipolar Depression in Young Adults Using fMRI
Phase: PHASE4
Conditions: Bipolar Disorder, Major Depression
Sponsor: The Cleveland Clinic

 
 
Differentiating Unipolar and Bipolar Depression in Young Adults Using fMRI 
 
7/28/2014 
 
NCT 01811147 
 
 

 
Image Acquisition: 
 
MPRAGE: A high-resolution anatomical volume will be comprised of 160 sagittal slices with 
slice thickness of 1.2 mm, TR/TE 2300/2.98 ms and have 1.0×1.0×1.2 mm voxel dimension. 
fMRI: All Echo planar imaging (EPI) images will be acquired using a TR/TE 2800/29 ms; 39 
slices and 3.5 mm slice thickness. 
Resting state connectivity: Two resting state scans will be acquired one with eyes open and the 
other with eyes closed. During the eyes closed resting state session the subjects will hear a 
beep sound every 2 minutes to assure they are not asleep and will be asked to press the button 
box when they hear it. 175 image volumes will be acquired during 8:166 min duration. In the 
eyes open resting state session the subjects will be asked to look at a cross sign on the monitor 
during which 132 image volumes will be acquired in 6:16 min. 
Maintain & Suppress: During the maintain session the subjects will be asked to maintain their 
emotions while looking at negative pictures and rate them at the end on a scale of 1 to 4 and 
during the suppress session the subjects are asked to suppress their emotions while looking at 
the negative pictures and rate them at the end on a scale of 1 to 4. In each of these sessions 
115 image volumes will be acquired in 5:366 min. 
Face-Task activation: This was developed by Hariri and colleagues to focus subjects attention 
on the negative facial emotion depicted reliably activates the amygdale and limbic regions. 
During face- task activation scan the subject are shown blocks of negative facial emotion 
pictures and a blocks of shapes. Seven trails are shown 3 of faces and 4 of shapes. The task 
involves the subject to match the face/shape on top with the one of the two faces/shapes shown 
at the bottom. 58 image volumes will be acquired in 2:7min. 
Emotional Go-NoGo task: This task combines presentations of emotional and non-emotional 
faces. The non-emotional faces consist of female and male faces. During the non-emotional trail 
the subject will follow the instructions whether to press the button or not based on the gender. 
There will also be a control GO only trail for the non-emotional faces. The emotional faces will 
have 2 different sets of faces one with happy faces and the other with fearful faces. The subject 
will follow the instructions whether to press the button or not when they see a particular 
emotional face. For the emotional faces there will be a neutral face control trail. During this task 
164 image volumes will be acquired in 7:65 min. 
DTI: 79 image volumes; 52 slices with a TR 7500 ms and 2 mm slice thickness will be acquired. 
GRE-field map: Dual echo (TE 2:46 ms; 4:96 ms) FOV 256 X 256; TR 300ms. 
 
The scanner was upgraded from Trio to Prisma.