Phase I, Single-Center, Open Label Trial of Ublituximab + Glucocorticoids for the Treatment of Acute Optic Neuritis and/or Transverse Myelitis in Neuromyelitis Optica (NMO) and Neuromyelitis Optica Spectrum Disorder (NMOSD)
Phase: PHASE1
Conditions: Neuromyelitis Optica, Neuromyelitis Optica Spectrum Disorder
Sponsor: Johns Hopkins University

Brief Title: Ublituximab for Acute Neuromyelitis Optica (NMO) Relapses 
 
Document Date: August 3, 2017  
 
Document: Protocol and Statistical Plan  
 
ClinicalTrials.gov ID: NCT02276963 


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Lsax sXL(m ua 86+69Sm%®)aXsba; nbabk X  lk  uu
 (u slmUx lslamlmsb (;s9%xamsb;6xlmlxoxa ®)WJa sasu
uLx(baLs ;b;sa  uu;)b naXtlmUbL(asb ;l;l;sbsnb m(sl msb;m
os sst auuanlmU(X k mslk sb X(Lnlsb uu (u slmUU ms;6sb 
X xlmlmUaXX soXmlmUc uu;X k XLUUX ;;lk mxLsuLF sb sst)
s XalX sx msb; 
	lUba; C9®®®xUDlmsXk mao;x sbLu(X ml;auam nluu Ulk msauu;oi s;
nlsb
cam lXx slk u ;lam;sam; sa sb sstaXlmUsa;smXa 
X ); XuL;(a;;lu lmsb s XalX sx msb; 6+W®xUa lmsXk mao;
oulsowlxnluu xlml;s X am sa b;oi s mXauu )
  aXsnluu  ao; amUlklmUsb oulsowlx; XuLlmsb ;s XalsX sx ms
(Xa ;;;(a;;lu )
 ;oi sh;xl;;lamaXsXm;  Xsasb abm;	a(tlm;
	a;(lsul; uL 6;smXa X sb X(Lnlsb;s Xal;nluu Ulm;;aam;
(a;;lu ssb aos;l ba;(lsu)b ;oi sxLsb m mXauulmsbl;sXlumX  lk 
am a; a oulsowlxamsb  lX;sLa ba;(lsulFslamssb abm;	a(tlm;
	a;(lsul sb sXm;  Xst ;(u nlsblmsb s XalX sx msb; )
uu;oi s;nba lusaulmluuLX ;(amLLWnluu X axx m  aX(u;x
 wbmU ;( X;smXa X ) m  lluX ;(am; l;U m XuuLam;l X m
lx(Xak x mslmsb ;( l l  llsC;Dsbsu sasb ba;(lsulFslam) ( mlmUam
sba; ;( l l  lls;6sb Xls XlsbsX Xaoslm uLo; sabm;	a(tlm;sa
lmls sX sx msX ;(am; C;DlmxasaX6; m;aXL6osamaxlmkl;ou omslam
X 3
9) mlx(Xak x mslm;sX mUsbLsb asaX ; Xbaomlu;sX mUsb;u 
Lsu ;s9 ouu(almslmsu ;ssnal;aus xo;u ;a su ;sam ulx6aX
%) mlmX ; a snaL usomlmU aXtomls;lmsu ;sam    s ulx)
8) 
x(Xak x mslman umfaXu X omslam Xaxlmamslm m sasu ;s
(XslukauomsXLamsXau)
+) mlx(Xak x mslmkl;ouolsLo;lmU ;l m uu m Tolku msa V%
ulm ;)

 ;oi s;amasX TolX X ;o nlsb(u;x wbmU  o; sb L ou luusb 
ulmluXls Xlak 6m
xL ( X aXx saam lXxX ;auoslama sb 
lm uxxsaXLu ;lamsaax(X saxl;;lam
); amsb 
masb X
ulmlu saX;6sb sX slmU(bL;llmxL(Xa  sal;bXU sb ;oi sbax aX
bmU sb (umsa ;us lxxoma;o((X ;;lamsa(u;x wbmU  aXamslmo 
sX sx msa sb os  w Xslam)  aX l;bXU  Xaxsb ba;(lsu6sb ;oi s
nluu ;b ou  aX auuano(lmsb ulmlnlsblmS®L;mExamsb;)
lmlmU;L
sbsxLlm uo m  ;uslamsa(u;x wbmU sL(luuLlmuo 
 ws m;lama  mbm x ms6lmkauk x msa m nX ;a sb m Xkao;;L;s xaXm
lmX ; lmsb X a %bL( Xlms m;lsL)	l;saXluuLxamUsb f

;oi s;sX s sabm;	a(tlm;6((Xawlxs uLW®Ja f;oi s;
lx(Xak  XaxX u(; nlsb;s Xal;uam )b asb XW®JX TolX  ;us X 
nlsb(u;x wbmU )
u;xwbmU X sx msb; 
baou;oi s;masx  sak ulmluXls Xlsa l;bXU bax 6 ;uslamsa
sX sx msnlsb(u;x wbmU l;;smXa X )

b (u;x wbmU sX sx ms(b;  Ulm;ssb  ma sb s XalX sx ms
b; mnluuu;so(sa9+L;)oXlmUsb u;xwbmU X sx msb; 6
;oi s;nluuom XUa9)®r9)Wkauox ;a (u;x wbmU  k XLasb XL
aXlmUsa;smXa X )ssb  ma sbl;(b; 6; am
xL 
( X aXx saax(X saxlsslmU
)
 mL oXsb Xos lxxoma;o((X ;;lk 
sX sx ms aXsb os  uX l;X TolX m(Xakl aXlmUsa;smXa 
X 6sb ;oi snluuamslmo sa  auuan  aX;  sLl;;o ;6ossb ulmlu
   lLsnluumas lmuo lmsb ;ssl;slumuL;l;)	l;saXluuLxamU
f(sl ms;sX s ssb abm;	a(tlm;	a;(lsu6((Xawlxs uLSWJa 
f(sl ms;nbaax(u s (u;x wbmU X l;bXU  auuanlmU
ax(u slama sb (u;x wbmU )

auuanco(
k XLxamsb s Xl;bXU 6;oi s;nluu  auuan nlsbxamsbuL uuaoms;
omslusb lX uuaoms;X (u s saxlmlxoxa ®)WJ aX(sl ms;nbanluuamslmo 
sa sX s nlsbc uu (u slmUU ms; aX(X k mslk X 6aXlmUsa;smX
a X 6aXsaxlmlxoxa WJ aX(sl ms;nbanluuo; asb X(X k mslk ;sXs Ul ;)

mlslam6ax(u s uaaaoms;nlsbl   X mslusasXtm osXa(bluaoms;m
ax(u s x saul(Xa lu ;nluu ax(u s xamsbuL;n uu)

b ; amXL   lLaosax l;m oXauaUl omslams auuano(S®L;mE
xamsb; s Xlmlsluba;(lsulFslam aXsb os X u(; )
mlslamsasbaXaoUb
bl;saXLm(bL;lu wxlmslam6lmuolmUXslmU6kl;ou wxlmslamm
slx nut6X ; Xb
a sb ;(lm nluu ( X aXx sLS®saax(X sa
sb X u(; u ;lam)

KBODBGBRG
X  mlmUCL®D6s XalX sx msb; CL;9saWD6u;xwbmU 
X sx msb; 6l m  ;;XLCL;Esa%®D6mauuanco(CxamsbuLuaas ;s;
mkl;ls;amL;S®m9I®D)
G OBC 
DOURBNC
gNO4
•
nlsbl   X msluC8(Xsl   X mslul; (su D
•
 Xoxb xl;sXL
•
 XauaUL	
6	6	C  (( mlwD
•
 Xox(X UmmLs ;s0s;X  mlmUmssb  ma sX sx ms)
•
lXlmaU mu k u
•
 uuaomsLulxls  uanLsax sXL(m u

CGRKUF CRO
R GRG
•

a sb    s X CXlm6 Xklu;(lm 6sbaXl;(lm Dnlsbmnlsbaos
UaulmloxamsX;s)
NGBCT TBF C
uu;oi s;nluuX  lk WL;a lmsXk mao;9®®®xUx sbLu(X ml;auam 
CX   XX saU m XluuL;p;s Xal;eD;( Xsb oXX ms;smXa X )

oi s;nluuuuX  lk +W®xUfLa lm o; ak X aoXbaoX;;ua; sasb 
am; sa ;s XalsX sx ms;(a;;lu 6oXlmUsb s XalX sx msb; )
b X  aX uu;oi s;nluuX  lk H;s Xal;)

uu;oi s;nluuX  lk (X cx lslam(XlaXsalm o;lama )


K F BRBNCi
((Xawlxs uL8®xlmos ;(XlaXsasb lm o;lama +W®xUfLa 6;oi s;nluu
 (X cx ls nlsbmmslbl;sxlm Cl(b mbLXxlm %WxUaX Tolku msD)
; a aXu sxlma(b mEW®xUCaX Tolku msDnluu uuan  aX;oi s;nba
 w( Xl m   k XaX(LX wl6aX;ulmluuLnXXms )


COUGBNCC
3OUGBNC
KBR KB
oi s; ulUlu  aX mXauux msxo;sx  suua sb  auuanlmUXls Xl3
9) u mnluulmUsa(Xakl nXlss mlm aXx am; ms)
%) 9Ic9®®L X;a U )
8)  nos a(slm oXlsl;mfaXsXm;k X; xL ulsl;)m nulmlu k msl;
  lm ;ulmluuL;lUml lmsm oXauaUl  llsC;Dam(bL;lu wx6mas
ssXlosu samasb Xl; ; (Xa ;;6nblbl;l   X ms Xax; ulm 
m oXauaUlu wx6mssXlosu sau ;lamlmsb ;(lmuaX6a(sl
m Xk aXXlm;s x) n;Lx(sax;xo;s X (aXs nlsblm9®L;a 
am; s)
+) am lXx aXblUbuL;o;( s lUma;l;a aXlmUsasb %®®E
X kl;lam;a sb lmU XbotlUma;slXls Xl aXClmU Xbot6
%®®ED6aX+(a;lslk ( Xsb ol ulm ;)aX6
;oi s;xo;sbk sna;auos Xls Xl3
) a(slm oXlsl;
) xL ulsl;
Csu ;ssnaa sbX  ;o((aXslk Xls Xl3
) (X ; m a amslUoao;;(lmuaX
u ;lam ws mlmUak XsbX  
aXxaX k Xs Xu; Ux ms;6
) 
Xls Xl;sl; LlmUsb X kl; amulUma;slXls Xl
 aX2auxm6%®99.
 ) c
UC+Dlm; Xox)
aX6;oi s;xo;sbk uamUlsolmuuL ws m;lk sXm;k X; xL ulsl;
CDX oXX msl;aus a(slm oXlsl;C
Dflus Xua(slm oXlsl;
CD6aXa(sla;(lmuxousl(u ;u Xa;l;CDsbsl;c
UaX+
mslaL(a;lslk )
W) b  uuaomsxo;s maXxuCWc%®Ja sasuuLx(baLs ;Dlm;oi s;
nbabk masX  lk masb X uu (u slmUsb X(Llmsb (;sL X)aX
sba; am uu (u slmUsb X(Lnlsblmsb (;sL X6 uuaomsa s
u ;s®)WJa sasuuLx(baLs ;l;m  ;;XL)
E)   xu ;oi sl; ulUlu sa ms Xsb sXlul ;b l;3
o as(X UmmsaXmoX;lmU0
o  mamcblu XlmU(as msluCl) )nax mnbabk b
bL;s X saxL6X (a;scx ma(o;u6nblbl;  lm ;5%L X;
nlsbaosx m; ;aX6lm  xu ;oi s;nbabk   m(a;sc
x ma(o;u aXq%L X;6xo;s am lXx nlsbauulu 
slxouslmU	aXxam C	Dm ;sXlauu k u;D6bk asbakXl ;
;oXUluuLX xak aXbk oXX msaox ms souulUslamD


 bluc XlmU(as msluCl) )nax mnlsb omslamuakXl ;mma
aox ms lx(lXx msa aklosuaXos Xlm  omslamsbsnaou
o; ;s XlulsLD)bl;s UaXLlmuo ;nax mnlsb
aulUax maXXba C k m; k X D6nax mnbaX ( Xlx ma(o;uaX
bk io;s Uomsax m;sXos )
o oi sb;m Uslk ; Xox(X UmmLs ;ss;X  mlmUmUX  ;
saam a sb  auuanlmU3
) ax(u s ;slm m  Xaxlms XaoX;  aXsb ( Xla Xax
am; mslmsasb sXluomsluExamsb; s Xsb u;sa; a 
lmk ;slUslamu(Xaos0aX6
) am;l;s msmaXX so; a am a sb  auuanlmU (su 
x sba;a lXsbamsXau aXsb ( Xla Xaxam; mslmsasb 
sXluomsluExamsb; s Xsb u;sa; a lmk ;slUslamu(Xaos3
l) XuamsX (slk ;C lsb Xaxlm aX(XaU ;s Xam amuLD
ll) 
mi su (XaU ;s Xam 
lll)  kamaXU ;sX ulx(ums;
lk) ;sXaU mlkUlmuXlmU
k)  Xosm ao;amsX (slk (sb ;
kl) 
msXos Xlm  kl C
DaXlmsXos Xlm ;L;s xC
Dnlsb
aox ms  luoX Xs a q9J( XL X
kll) u (Xsm X;s XlulFslamCk; saxLnlsbaox msslam
a Faa;( XxlD(XlaXsasb   xu ;oi sh; msXLlmsasb 
sXlu0sbl;xu xo;s sb ;au (Xsm X aXsb ;oi s
klll) aou XXl Xx sba3amaxmmauo;lk (
Cl(bXUxaX Xklufkous(;DnlsbkUlmu
;( XxlluU msC axfU uf luxfX xf;o((a;lsaXLD)

3OUGBNCKBR KB
oi s;x  slmUmLa sb  auuanlmUXls XlX CNR ulUlu mmmas mXauulm
sb sXlu3
9) oXX ms kl m aXtmanmbl;saXLa ulmluuL;lUml lmslm  slam
lmuolmU3
) bXamlaXamUalmUslk lm  slao;l; ; X TolXlmUuamUs Xx
;L;s xlsX sx ms;ob;6osmasulxls sa3(XaUX ;;lk xousl au
u ota m (bua(sbLCD6bXamlX mulm  slam6bXamlb ;s
lm  slamnlsbXambl s;l;6so Xoua;l;6aXslk b (slsl;)
) X klao;; Xlao;a((aXsoml;slaXsL(lulm  slam;)
) 	l;saXLa (a;lslk ; XauaUL aXb (slsl;)
) XlaXbl;saXL6aX;o;(llam6a so Xoua;l;CD)
 ) 	l;saXLa (a;lslk ; XauaUL aX	
)
%) 	l;saXLa ulmluuL;lUml lmssXoxC )U)sXoxslXlmlmioXL6
 X Xuamso;lam6;(lmuaXax(X ;;lamD
8) ;saXoXX msbl;saXLa x luuL;lUml lmsk X;     s;ClmuolmU
uu XUlX slam;D Xax3

) aXsla;s Xal;
) l(b mbLXxlm 
) oXlm aXxao; fboxmblx Xlmslal ;
+) ;saXoXX msxulUmmL6 w (s aX
)  XkluXlmaxsU 9aXu ;;
) amclmk;lk ;u uum;Toxao; uu;tlmXlmax
) m XlUma; ;nlsboXslama ax(u s X ;(am; 
CX xl;;lamD5WL X;
ABGRNKrN A FRNONTBFOBTCCr 3OU GGUL R KNF
SKRBBSRBNCtK TKO GGN K GSNCG o
W) lUml lmsamoXX ms6omamsXauu x luamlslamlmuolmU6osmas
ulxls sa6Xl6X mu6b (sl6b xsauaUlu6U;sXalms ;slmu6 maXlm 6
lxxoma  ll mL;LmXax 6(ouxamXL6 X Xu6(;LblsXl6aX
m oXauaUlul; ; nblbaou   ssb ;oi sh;;  sL6lx(lXsb 
;oi sh;X ulu (Xsll(slamlmsb sXlu6lx(lXsb  kuoslama 
 m(alms;6aXm  ;;lss sb o; a x lslammasuuan Lsb (Xasaau6
; s Xxlm Lsb 
a sb sXlu)
E) ; a mlmk ;slUslamuXoUaXasb X w( Xlx msusb X(L aXamlslam
asb Xsbmnlsblm+n  t;6W(bXxatlm slbu ulk ;aXoXslama 
lauaUlu    sCnblb k Xl;uamU XD(XlaXsa;X  mlmU)
G) oXX ms(Xsll(slamlmmLasb Xlms Xk mslamuulmlusXlu)Xsll(slam
lmmamclms Xk mslamusXluX TolX ;((Xakua sb (XasaauLlmk ;slUsaX)
I) oi s;nbaX amoXX msuLX  lklmUmLasb Xlmk ;slUslamuU ms;6aX
bk (Xsll(s lmmlms Xk mslamuulmlusXlunlsblmsb u;s%9L;6
aX;oi s;nbabk   mklms nlsbulk klm q%xamsb;(XlaX
sasXlulmuo;lam)
S)  o; sb X l;momtmanmos(as msluXl;t aXk X;  k ms;lm
moX;lmUlm ms;; amXLsasX sx msa sb xasb Xnlsboulsowlx
X ;s   lmU;baou l;amslmo l sb xasb Xl; mXauu )
UF KN 
GUL RG
lk CWD;oi s;nluu  mXauu saX  lk H;s Xal;)
NSUORBNCG

CR CRBNClNlK Rg
4ruu;oi s;nbaX  lk am a; a sXlux lslam
CD

 KKNRNNOg4ruu;oi s;nba( X aXx uukl;ls;lmaXm nlsb
(Xasaaunlsbaos;lUml lms(Xasaau klslam;aXklauslam;

  RrNSUORBNCruu;oi s;sbsX  lk am a; a sXluXoUCD

RRBGRBOBGGU G
XlxXL  sL;; ;;x ms;3;oxxXLa sb mox Xm( X msU a ;oi s;
nlsbmLk X;  k msCD6mL; Xlao;k X;  k msCD6k X;  k ms;
u lmUsa( Xxm msl;amslmoslama sXluXoUmsXluXoUcX us k X; 
 k ms;nluu X (aXs )

 amXL  lL;; ;;x ms;3bmU lmm oXauaUlaosax ;amsb 6lx 
%Wcaasutm	;u ; Xaxxl;;lamsal;bXU CLWaX%9D6m
 auuano(CL;S®m9I®Dnluu muLF L(lX scs ;s;nlsb;lUml lms(c
kuo ;am;l X u ;;sbm®)®W)ulmlum oXauaUllx(Xak x msl;axxamuL

a; Xk lm5EEJa ;oi s;sX s ssb abm;	a(tlm;	a;(lsu)b 
 UX  a lx(Xak x mslmsbl;sXlu(a(ouslamb;mas  m Tos uLTomsl l 
bl;saXluuL)L
6u mUsba %bL( Xclms m;lsLmu mUsba 9c(a;samsX;s
 mbm x ms;baou ;su aXX o Ll;bXU )(lX scs ;snluu o; 
saax(X sb ; kuo ;nlsb;lUml lm am;l X s(ckuo ;u ;;sbm®)®W)

FSO GBa 
b ;x(u ;lF a W;oi s;lmsbl;;lmUu Xx;soLCH;s XalDl;; am
  ;llulsLmuaUl;sluam;l Xslam;amsb mox Xa ;oi s;sbsnluu m;oX 
X ulu ;  sLX (aXsa oulsowlxcx ls  uu; (u slamlmsb (sl ms
(a(ouslam)

mlm ( m mssm  sLamlsaXlmUaXCDnluu ax(a; a  lk 
x x X;nlsbsu ;sam x x Xnbal;m
m  slao;l; ; ( lul;s6
	 xsauaUl;s6 oXauaUl;s6ssl;sllm6mmasb Xlm ( m ms w( Xsnlsb
 w( Xl m am;; ;;lmU;  sL)bX  a sb x x X;nluu am;s  ssb 
abm;	a(tlm;mlk X;lsL)b nluu X kl nlmUsb ;  sLs s Xsb  lX;s
sna;oi s;X  mXauu max(u slmUsb s XalX sx msb; sa s Xxlm 
l ls;  saamslmo sb sXlu)b nluu;oxlssb lX lmlmU;sasb (am;aX
 s X k XLx  slmUmsasb 
)x  slmU;m lmc( X;amaXkl
s u am  X m aXaxlmslama sb asb)b ssa o;  aXX kl nLsb 
nluu souXnsX aX lmsb s; )b ulmlusnluu 
xamlsaX Lb X( osl;mnluu To XLc X  (XlaXsaX kl nLsb )

UKRBNCN 
UL R
KRBBSRBNC
(saSxamsb;





K DBRBNCGC  BCBRBNCN  KFG

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
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
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
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m ( m mssbl;axxlss  C
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U

xxomaUuaoulm

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ms Xmslamuam  X m am	Xxaml;slama  bmlu TolX x ms;
 aX Ul;sXslama bXx oslu; aX	oxm; 



mk ;slUslamu llmuXaos



m;slsoslamu kl naX



msXk mao;
t
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Um sl ;amm 
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m;slsos raXtlmUXao(
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
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
(sla;(lmu;u Xa;l;

K DBRBNCGC  BCBRBNCN  KFG

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
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aXu	 usbXUmlFslam


0 
0o0 

 oXaxL ulsl;(slCDl;; k X 6 xL ulmslmUosalxxom l; ; a sb  msXum Xkao;
;L;s xsbs(X   X msluuL   s;sb a(slm Xk ;m;(lmuaX)usbaoUbbl;saXluuLam;l X 
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(XaUma;sluuLmb;(sba(bL;lauaULomX ;(am;lk sasL(lusX sx ms;2 lm;b mt X
%®®G0lxXaoUb6 su)6%®9%.)
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To(aXlmc+6n; aomsa ;;als nlsb)ax(X sa6 wblls;mau XU s
am; s6(aaX X(XaUma;l;6mXXlsLa  X Xa;(lmu uolaulUauamu
Um;)sst;
sL(luuL(Xao xa Xs sa; k X l;lulsLsbsu ;saoxouslama l;lulsLnlsb b
sst0 sn  msst;6(sl ms;U m XuuLX xlmm oXauaUluuL;su nlsbaos kl m a 
(XaUX ;;lk  s XlaXslam)b X  aX 6lsl;XolusbsUUX ;;lk sX sx ms aX bX u(; l;
a(slxlF sa(X k msl;lulsL)

   s;(X axlmmsuL  xu ;6nlsb  xu saxu Xslaa E)W39)b X uslk  X To mLa 
xamU xL ulmslmUl;aX X;l;Tols kXlu 6 lmUblUb Xlm;lm6	l;(mlm Xlm
(a(ouslam;ax(X sanbls ;)b   n(a(ouslamc; (X ku m ;sol ;a amos 
(Xakl (X ku m Xs ;a ®)8%sa8)9( X9®®6®®®lmsb mamcnbls (a(ouslam2mbUa(u6 s
u)6%®9®.

ulmluuL  lmls l;  lm Lbl;saXLa a(slm oXlsl;mbl;saXLa sXm;k X; xL ulsl;
nlsbmamcXlm
6uamUlsolmuuL ws m;lk xL ulsl;u ;lam;mfaX(X ; m a sb c
U
laxXt X) Xam Uslk (sl ms;nlsbsXm;k X; xL ulsl;ma(slm oXlsl;xo;sbk 
uamUlsolmuuL ws m;lk xL ulsl;mXlm
sbsl;massL(lu aXxousl(u ;u Xa;l;)
( sXoxl;aX XCDl;  lm ;+mslaL(a;lslk lmlklou;nlsbIra(sl
m oXlsl;aXsXm;k X; xL ulsl;)

ax(Xl; sb ;(sluuLulxls ;LmXax ;a uamUlsolmuuL ws m;lk sXm;k X; xL ulsl;
CD6X oXX msl;aus a(slm oXlsl;C
Dflus Xua(slm oXlsl;CD6m;lm
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 k ua( ulmluuL  lmls  s X auuanco(slx a su ;s%L X;nlsbsb asb X;lwC+EJD
X xlmlmU) lm;b mt X su)6(Xa;( slk uL;sol %S(sl ms;nlsb lX;s k msa )
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X oXX mssXm;k X; xL ulsl;DaX k ua( a(slm oXlsl;Clmlslk a m oXaxL ulsl;a(slD)L
amsX;s6ma; Xam Uslk (sl ms;X u(; ak X9rGL X; auuanco()m;lmbk 
;lxluXm oXalxUlmU6; XauaUlu6mlxxoma(sbauaUlubXs Xl;sl;6msb l   X m l;
(XlxXluLam a u;;l lslam;lm(msb ; lmlklou;X lUma; nlsb6oslmaXsb
x XlmoXa( 6sb ; (sl ms;X lUma; nlsb2s;oat6 su)6%®®G0lmU Xbot s
u)6%®®G.)

b oXX ms;smXa X  aXsX sx msa os sst;a asba(slm oXlsl;m
sXm;k X; xL ulsl;l;WcLaoX; a blUba; x sbLu(X ml;auam C9®®®xUluLDClxXaoUb
%®9%D)
m;ax (sl ms;6sbl;aoX; a ;s XalsX sx msl;;o  ll mssa;o((X ;;lm uxxslam
mX k X; ;ax m oXauaUlL; omslam)saX;sbsxL(X ls;o ;;nlsb;s Xal;uam 
lmuo ;xuuu ;lamoUbs XuLlmsb (Xa ;;mamoXX ms(X k mslk 
lxxoma;o((X ;;lam)
mxmL(sl ms;6;s Xal;X mas;o  ll mssa;o((X ;;lm uxxslam6
msX sx ms ;uslamsa(u;x wbmU l;m  ;;XL)lk Lu ;a 9)®r9)Wkauox  wbmU ;
X TolX mlslamu%cn  tlm(sl msba;(lsulFslamm msXuulm sb s X)u;x wbmU 
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 wbmU l;;smXa X lm;s XalcomX ;(am;lk (sl ms; o; lsl;W®cG®J    slk lm
X olmUslk lm uxxslammX olmUlm uxxsaXLxU lmsbl;(sl ms(a(ouslam

CFF (laXtan;tl%®9®D)uslxs uL6m oXauaUlX ak XL s XblUba; ;s Xal;m(u;x
 wbmU m ;sXsl l lmsasbX  UXao(;3UXao(sbsa ;maslx(Xak suu6UXao(sbs
lx(Xak ;;ax osxlmslm;;lUml lmsm oXauaUl  llsmUXao(sbslx(Xak ;n uul mas
tsa; ulm )

b Xslamu  aXo;lmUoulsowlxl;; amsb tmanmXau ;a  uu;6mslaL(Xaoslamm
(u;x uu;lmsb (sba(bL;lauaULa )l;bXs XlF Lsb (X ; m a mmslc+
mslaL6nblbmamuL (Xao Ll   X mslslama  uu;sa(u;x uu;) o; sb ; 
mslc+mslal ;xL (sbaU ml6 uu;X aUmlFlmU+xL lX suLlmkauk lmsb 
l; ; (Xa ;;;n uu) uu;u;a(uLXau ;(as msmslU m(X ; mslmU uu;lm)b 
;sXamU ;s kl m a sb lx(aXsm a  uu;lmax ; Xax;sol ;a  uu (u slam6xa;s
axxamuLnlsbmslc%®xamauamumslaL6XlsowlxClsowm4D)lsowlxb;  m;banm
lm lk X sXa;( slk msna(Xa;( slk ;sol ;sa     slk lmX olmUX u(; ;o(sa
S®Jmbl klmUX xl;;lamlmo(saI®Ja (sl ms;;au uLLls;slamam%®H uu;6 ;(ls 
mabmU lm(u;x uu(a(ouslammmslc+mslaLsls X;)b ; boxmsXlu;;sXamUuL
;oUU ;sXlsluXau  aX uu;lmsb (sba(bL;lauaULa boxml; ; )blu sL(luuLo; lm
sb (X k mslama l; ; 6c uu (u slamxL  m  llulmsb sX sx msa mos X u(; ;
n uu)x XUlmU kl m lmls ;sbs( Xl(b Xu uu;X slks oXlmUX u(; m
(u;xu;s(Xaoslama mslc+mslal ;;(lt ;) uu;X u;a aomnlsblmos u ;lam;
a sb ;(lmuaXma(slm Xk ;oUU ;slmUXau ;asblmsb uaamlmsb  msXum Xkao;
;L;s xoXlmUX u(; )

0of 
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 mbm slklsL6 wbllslmUomlTo UuLa;Luslam(Xa lu nlsbuan Xosa; ams ms)
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ulsowlxb;u;a  m xam;sXs salmo (XaUXxx  uu sbCD)ulsowlxb;
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K OBCBODOURBNCGN OBRU3BF


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uLx(baLslu ot xlCD uu;ax(X saXlsowlx)ulsowlx xam;sXs lx(Xak N
X  (saX

CN

Df9ElmlmUmN

 ( m ms    saX omslam;ax(X sa
Xlsowlx)lslamuuL6oulsowlxlmo blUb XlmklsXaUlm;s uu;6mblUb X
N

x ls lms Xu otlmc%C
%D(XaoslamLN

HoXts uu;2 ax o  su)%®®I.)
ulsowlx xam;sXs blUbUlm;sasb(sl msc Xlk  uu;m	 uuulm ;)
Ulm;ssb 	 uuulm xa;6oulsowlxn;a; Xk salmbllssb am;slsoslk uLslk c
M;oXklku(sbnL6mlmo sb  w(X ;;lama uamUnlsblmbllslama sb 
8c
(sbnL)ulsowlxu;almo sb  w(X ;;lama (Xac(a(sasl saX;6; m;lslFlmUxa; uu;
sa
x ls (a(sa;l;)2Xlstl su)6%®99.




b mslsoxaX    sa oulsowlxn;ax(X sasbsa Xlsowlxnlsbb xasb X(Llm
 auulouXuLx(baxCD6mxmsu  uuuLx(baxCDw maUX sxoXlm xa u;)lmUu U ms
oulsowlx xam;sXs a; cX us mslcsoxaXslklsLnlsb9®®JsoxaXUXansblmbllslamlm
sb w maUX ssa; a 9®®xUftU6m;o( XlaXsoxaXUXansb uLC%9L;Dax(X sa
Xlsowlx)ulsowlxu;a xam;sXs ;o( XlaXmslcsoxaXslklsLax(X saXlsowlx
Ulm;sw maUX s;suua; u k u;)2;s k ; su)6%®99.


	
A CNClOBCBORN3BNONTrSKNTKF.GS K NKF NKBCTRN
	VTUB OBC 
IX ulmlu  sLkuoslama las bmauaUL Xlk bXx oslu;eC
mk ;slUsaXXaboX D)
b sawllsL;sol ;( X aXx sa ;sul;bsb ;  sLa oulsowlxn X amos aXlmUsa
aaaXsaXLXsl CDX TolX x ms;6lmuolmUkulslama sb muLslux sbao; 
 aXsb ; XoxmuL;l;a oulsowlx)b ulmlusawlauaUL;sol ;amos sas nlsb
oulsowlxX ;oxxXlF lmu 9 uan)

O 0iN3BNONTr

rS N GRUr
 GRGrGR F
 RANN 
FBCBGRKRBNC
NG G
 SNKRC5

lmUu a; 
sawllsL
LmaxauUo;
xamt L


lmUu a; %n  t;
a; Xkslam
®6®)869®m9®®
xUftU

8%IGS
 ;
 ( s a; 
sawllsL
LmaxauUo;
xamt L


  tuL aX+n  t;
®69®mW®xUftU

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 ;
Lsatlm X u ; 
LmaxauUo;
xamt L


W6%®6E®xlmos ;m
EbaoX;
9®mW®xUftU

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 ;
ausau Xm 
LmaxauUo;
xamt L


+n  t;
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
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ausau Xm 
 n um
nbls Xls

m
lmUu a; 
9®xUftU
%®®G®E®W
 ;
osU mllsL
Cx ;s ;sD
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mklsXa
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
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 ;

xxomaU mllsL
LmaxauUo;
xamt L


+cn  t
9®mW®xUftU

8%II®
 ;

3 msX 
ms Xmslamu awlauaUl )	iIriIti tlt t iIr,c3 msX   b Xb ;lauaUlTo ;
CiIrtrt t (rD)
3
m;slsos;s oX luu C  (Inr	i(IInID


m;lmUu ca; sawlauaUL;sol ;6oulsowlxl;(uL ;  sL(Xa lu ;lxluXsanbsxlUbs 
 w( s  aXmslc%®xamauamumslal ;)lmUu xlml;sXslama o(sa9®®xUftU
oulsowlxlmLmaxauUo;xamt L;n;n uusau Xs 6nlsbmauaulXXlsslamnlsblmsXk mao;
xlml;sXslam) masawllsL;sol ;Cx ;s ;sD;ban sbsoulsowlxn;masxosU ml)
amt L;sbsX  lk ;lmUu lmi slama ®)8xUftUa oulsowlx k ua( mmslcoulsowlx
X ;(am; 6nb X ;mslcoulsowlxmslal ;n X mas s s lmsb mlxu;6nblbX  lk 9®
aX9®®xUftUC
mk ;slUsaXXaboX D)

X ( s ca; sawlauaUL;soLsX s LmaxauUo;xamt L;nlsboulsowlx
lmsXk mao;uLsa; ;a ®69®aXW®xUftUn  tuL aX+am; oslk n  t;)s9®xUftU6ma
 kl m a sX sx mscX us sawllsLn;a; Xk  w (s aXsb  w( s (bXxauaUlu    s
amnbls uaa uumuLx(baLs aoms;C;xuu X ; o saua;;a  uu;D0masawlauaUlu
    s;amsb b xsauaUluaXuaalab xl;sXL(Xx s X; kuos n X a; Xk )sW®
xUftUa; 6snamlxu;(X ; ms nlsb(aaXU m Xuulmlu;lUm;CbL(asb Xxl6bL(aslklsLm
(Xa;sXslamD)b   xu ;ban sb ; ;Lx(sax;;sXslmUamL9Wmn;(X xsoX uL
;Xl l amL%® s Xsb sblXxlml;sXslama oulsowlx6nb X ;sb xu (X ; ms nlsb
sb ; ulmlu;lUm; s Xsb  aoXsblm o;lammX ak X nlsb;Lx(saxslsX sx ms)


mX uslamsasb (XlxXLslklsLa oulsowlx6uLx(bal (u slamn;lmo lmsb ;(u  mm
uLx(bma ;sasbsb 9®xUftUmW®xUftUa; ;)
m;ax mlxu;6 X ; lmsbLxo;m
;(u  mn lUbs;n;a; Xk )	l;sa(sbauaUlu wxlmslam;ban ;(u  mmuLx(bma 
sXa(bL6xaX (Xamaom ssb W®xUftUa; )lslamubmU ;   slmUsb 
b xsauLx(ba(al slax(Xsx msC%®c w(X ;;lmU uu;Dn X  aomlmsb uomU;6ulk X6tlm L;6
X mu;Cu otaLsa;l;6 wsXx ouuXLb xsa(al ;l;Dmam xXXanClmX ; 
xL ualf XLsbXalXslaD)
ml   X msaXUm;a ;ax mlxu;6xmLlxxsoX  uu;n X a; Xk 
nlsblmsb k ;; u;)

	 (sllm uxxslamn; xam;sXs ssb 9®xUftUa; lm9a Emlxu;)	l;sa(sbauaUL
 xam;sXs puo;s Xea b (slu ;lam;3xlmlxu;lmUu  uum Xa;l;6;ulUbsuLslks o(   X
 uu;mxlmlxulm uxxsaXLbmU ;)
s;baou mas sbssb c uu (u slamlmsb 
( Xl(b Xuuaa;n uu;lmam xXXann;(XslouXuLxXt lmsbl;mlxu0o(amm Xa(;L6
X oslama c uu;n;SSJlmsb am xXXan6nb X ;sbl;kuo X b ((Xawlxs uLEIJ
lmsb asb Xxamt L;sX s nlsb9®xUftU)ssb W®xUftUa; ;lmUu c uum Xa;l;n;xlmlxu
Cm/%DaX;ulUbsCm/%D aX+a sb Examt L;mslkslama sb o(   X uu;n;;ulUbsCm/%DaX
xa Xs Cm/9Dlm8aosa sb ; +mlxu;)ax lm uxxsaXLbmU ;n X mas )

(a;;lu bL(asb ;l;sasb a; Xk xlmlxub (slu ;lam;l;sb X ;oXU m a (sbaU m;
o; Lsb lxxoma;o((X ;; ;ss a sb mlxu);sb ulk X mFLx slklsl ;C6D
n X masxal l m;lm oulsowlxlmasXa;;cX snlsbsb ulk Xlmsb sl;;o cXa;;
X slklsL;;L6sbl; lmlmUn;am;l X mamck X;     s); amsb ; sawlauaUL
;sol ;lmmamcboxm(Xlxs ;6sb ulk Xaou sXU saXUmm;( luss mslam;baou 
(lsab (slxamlsaXlmU6msa;oulmlulm  slam;6nblbmlx(sb (sl(Xx s X;;ob
;bXamlb (slsl;)

OBCBO D ONSF CRN OBRU3BF
as 688(sl ms;nlsbX u(; aXX  XsaXLbk   msX s lm lX;sclmboxma; 
 ;uslam;soLC(Xasaau%®c®G®8D)sl ms;X  lk  lsb Xam n  tuLlm o;lama ;lmUu U ms
oulsowlx aX+a; ;sWl   X msa; u k u;C(Xs
DaXn  tuLIca; X Ulx msam a; 
u k uC(Xs

D)Xs

o; mlmlslua; a 9W®xU auuan LGa; ;a +W®xUCsasua; 88®®
xUD)

AKFNEBC RBG
 s Xlmi slama oulsowlxnlsb9W®xUa;  auuan L; k mn  tuLlmi slamnlsb+W®xU6
X ;ous;;oUU ;s mamculm X(bXxatlm sl;nlsba; C+W®xUk;9W®xUDmslx Cn  t+k;
n  tID3xaX sbm(Xa(aXslamulmX ; a xwm:o sau Xm  X ; )b 
kauox a l;sXloslams;s L;ss n;;xuuCzWD6((Xawlxs uL Tousauaakauox )
b ; mamculm X(bXxatlm sl;xL  w(ulm LlmlmUa oulsowlxsals;sXU s6nlsb
uXU ax(am msa sXU scx ls  ulxlmslam s Xsb  lX;sa; sbsl; X ;  s X
;o; To mslm o;lam;o saX oslamlmsb kluu sXU s)	an k X6ulxls s aX ba; 
u k uabaXsmam;l Xu kXllulsLlm; ulm (sl msbXs Xl;sl;6(XslouXuLlms Xx;a 
soxaXoX m6xt  lXxamuo;lam;l  lous)

b ulm Xx m; Xoxam msXslamcslx ;(Xa lu  s Xsb  lX;s6sb  aoXsbmsb  lUbsblm o;lam
a oulsowlxX (X ; ms lmlUoX 9);oxxXLa mamcax(Xsx msu(Xx s X; s X
sb  lX;s6sb  aoXsbmsb  lUbsblm o;lama oulsowlxX (X ; ms lmu %)


BTUK 0iBC KF CG KUFNC CRKRBNClRBF GSKN BO  R KRA  BKGRtRA  NUKRACRA  BTARA
BC UGBNCN UOBRU3BF


C8(sl ms;0SJD)s XoUcX us ;6l) )aoXXlmUxaX sbmam n  t s Xsb u;slm o;lama 
oulsowlx6am;l;s  ;; msluuLa lm  slam;Cm/9%Dmm osXa( mlCm/+D)

n msLcsbX  lm o;lamcX us X slam;C
;Dn X X (aXs lm%®(sl ms;69Ea sb xUX %
mGC8lm(Xs
6+lm(Xs

D6UX 8)lws  ma sb ; %8
;aoXX  s Xsb  lX;slm o;lama 
oulsowlx68 s Xsb ; amlm o;lamm+ s X;o; To mslm o;lam;)X 8lm o;lamcX us 
X slam;X TolX lm o;lamlms XXo(slammX ;auk nlsbaos; To u  s X;Lx(saxsl
sX sx ms;ob;aXsla;s Xal6mslbl;sxlm ;6awLU msb X(L6mXambalusaX;lm; a 
Xamba;(;x)

n msLsbX   (l;a ;a XoUcX us (LX wln X X (aXs lm%®(sl ms;0xluCq8S1D aX%®
 (l;a ;mxa Xs C Xax8Ssa+®1D aX8 (l;a ;)	 b ;6bluu;6mo; m;sb ml
n X uuX (aXs ;xlusaxa Xs ;)

l s  mXoUcX us lm  slam;n X X (aXs lmS(sl ms;) ma sb ; h;n X xlusa
xa Xs X ;(lXsaXLsXslm  slam;6b X( ;X oXX m ;aXmu; ;; ;)m UX 8ul;s Xla;l;
n;lUma; ssb slx a sb +sblm o;lam auuan LUX 8Xamba(ouxamXL
;( XUluua;l;%xamsb;us X)m UX 8kXl uun;X (aXs lmam (sl msmX TolX 

sX sx msnlsbLuaklX)masb X(sl msnlsbx lubl;saXLa aXslkuk X (u x msm
;s(bLuaau maXlsl;X  lklmUoulsowlx(X ; ms nlsb%UX + (l;a ;6IrhIttn(
 I; (;l;sb mIh  ttn(nrn(; (;l;nlsb maXlsl;)kauoslamn; kaXu 
 s Xmsllaslsb X(L)uusb ; lm  slam;X ;auk nlsbaos; To u  w (sIh  ttn(nrn(
; (;l;ax(uls nlsb maXlsl;6nblbX ;auk  s Xkuk X (u x ms)

n msL (l;a ;a XoUcX us m osXa( mln X a; Xk lm9W(sl ms;;n uu;%lslamu
; ;a   Xlu m osXa( ml)lUbs (l;a ;C+®J0+lm(Xs
m+lm(Xs

Dn X UX 8
m osXa( mlmG (l;a ;C8WJ08lm(Xs
m+lm(Xs

Dn X UX +)
m(Xs
6uu (l;a ;
osam aoXX nlsblmIL; s Xsb  lX;sa; mX ;auk ;(amsm ao;uL ;(ls amslmoslam
a sb sX sx msnlsboulsowlx)LamsX;s6lm(Xs

6UX 8c+m osXa( mln;a; Xk  s X
sb sblXlm o;lamlm8; ;6 s Xsb GsbaXIsblm o;lamlm8; ;6mus Xlmsb u;ssna; ;)
X sx msnlsbUXmouaLs auamL;slxouslmU saXCcDn;;sXs lm+; ;u lmUsa
X ak XLsamaXxukuo nlsblm9sa8L;)aoX; ;X ;auk ;(amsm ao;uL)

u k m (l;a ;a XoUcX us sbXaxaLsa( mln X X (aXs lm9®(sl ms;am;l;slmUa 9®
UX 9c%m9UX 8)lm a sb  (l;a ;X (aXs aoXX u ;;sbm+Ib s Xsb ;sXsa 
oulsowlxlm o;lam)

XoUcX us (mLsa( mln;X (aXs lm8(sl ms;C9UX 8m%UX + (l;a ;D)aXuua 
sb x6xlusaxa Xs (X c wl;slmU(mLsa( mln;(X ; mss; ulm )uuosam (sl ms ouuL
X ak X )b u;sam n;(X xsoX uLnlsbXnm Xaxsb ;soLo salUma;l;a 
amaxlsms; amXLu ot xl)

lw(sl ms; b w( Xl m am XoUcX us  u ks ulk X mFLx  k ms6Cl) )lmX ; ak X%wlm
uam 6aXfutulm ba;(bs; Xsla5aX TousaWDC;  u 8D)lk aosa sb ; E
 (l;a ;n X UX 8;nb X ;sb Esbn;UX %)aoX (l;a ;aoXX ;aam s Xsb  lX;s
lm o;lam6am aoXX  s Xsb ; amlm o;lam6msb u;sam n;a; Xk  s Xsb +sb
lm o;lamlm(sl msnlsbx lubl;saXLa bXamlxlw b (sa uuouXmbau ;sslulk X
l;aX X)uua sb xn X ;Lx(saxsl6l;aus 6msXm;l ms) lsb XlmX ; u k ua 
lulXolmmaXlx(lX (Xas lm;Lmsb ;l;n X X (aXs ) ak XLn;;(amsm ao;nlsbaos
X oXX m  s X;o; To msoulsowlxlm o;lam)

O piK flp O DR OBD K CarF GUGS R RN K OR RNUOBRU3BF

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;sXsa sb ;soL)

xamUsb 89W aX x mslam ;68Sn X X (aXs ;; Xlao;k X;  k ms;CD6%8a sb x
 lmU;o;( s sa X us sasb ;soLXoUC;  u +D)
sl;samas sbssb ; %8;
aoXX lm9W(sl ms;)uua sb ; ;X ;auk nlsbaos; To u  w (sIh  ttn(nrn(
(h((C(sl ms®+c®+Dm; a (mLsa( mlo sa; amXLu ot xl aXnblbsb (sl ms
n;(X xsoX uLnlsbXnm Xaxsb ;soL)

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m o;lamX us X slam
8

®Gc®9
l;s Xla;l;
8

®Gc®9
Xamba(ouxamXL;( XUluua;l;
8

®9c®8
LX wl
%

®+c®+
sX (saau; (;l;
+

®+c®+
s(bLuaau; (;l;ax(uls nlsb maXlsl;
+

®9c®+
 Xlu m osXa( ml
8

®%c®%
os lm o;lamX slam
8

®%c®%
mLsa( ml
+

®8c®+
os lm o;lamX slam
8

®8c®+
Xl uu
8


®%c®8
 osXa( ml
+


®%c®8
LX wl
9


®8c®E
u ks lk XmFLx ;
8


®8c®E
 osXa( ml9
+


®8c®E
 osXa( ml%
+


®8c®G
LX wl
%


®8c®S
os lm o;lamX slam
8


®+c®W
os lm o;lamX slam
8


®Ec®E
os lm o;lamX slam
8


®8c®I
 osXa( ml
+


®9c®E
mLsa( ml
+


®9c®E
 Xlu m osXa( ml
8
,aXlmUsak8

am a sb  aX x mslam ;b;  mam;l X ;a; culxlslmUsawllsLaXlmUsb 
ioUx msa sb ;soL  sLaxxlss  )b X  aX 6sb xwlxoxsau Xs a; b;mas  m
X b L s)

  Br
 xaUX(bls aXsb (sl ms; mXauu lmsb ;soLn X ; auuan;)b x lmU a sb 88
(sl ms;n;E+L X;CXmU +8cGGD)sl ms;bX  lk 8CXmU 9cIDulm ;a mslm Xsb X(L
(XlaXsa;soL msXL6Ea sb xX  XsaXLsasb lXxa;sX  mssX sx ms)lUbs  m(sl ms;CWWJD
n X (X klao;uLsX s nlsbXlsowlxcamslmlmUsb X(Lssb slx a lmuo;lamlmsasb ;soL)
uu(sl ms;osam (X ; ms nlsbuLx(bma  muXU x ms699C88JDa sb xbklmUoutL
C5WxDuLx(b ma(sbL)n msLam (sl ms;CEIJD(X ; ms nlsb;(u max UuLmWC9WJD

nlsbb (sax UuL) lmuaauLx(baLs aomsn;8E)Gw9®SfCXmU +)8Gc%9+D) lm
b xaUualmm(us u su k u;n X 99)SUfum9®Gw9®Sf6X ;( slk uL)blXs  mC8SJD
(sl ms;bm
Ukuo qEUf)

ulmluX ;(am; n;; amsb Xls Xl ;sul;b Lsb slamum X
m;slsos C
Dc
aXtlmUXao(o(s lm%®®ICWD) ;(am; sn X kluu  aX%S(sl ms;69Iaosa %9lm
(Xs
m99aosa 9%lm(Xs

)aax(u s X ;(am; ;n X a; Xk nbs k Xsb abaXs;)
n uk C+9JD(sl ms;n X lm(XsluX ;(am; CDsxamsb+6Wf9Ilm(Xs
6mGf99lm(Xs

)
n;am lXx %xamsb;us XlmIC%IJD(sl ms;68fWlm(Xs
mWfG(sl ms;lm(Xs

)


FFUC    RG
lUml lmsuaauLx(baLs  (u slamn;a; Xk lmuu(sl ms;X  u slmUsb lms m 
lauaUluslklsLa oulsowlx)
msb +ca; (Xsa sb ;soL6uLx(baLs  (u slamn;
xwlxuam n  t s Xsb +sba; a oulsowlxnlsbx lmuLx(baLs aomsa ®)Sw9®Sf
lmabaXs6aXX ;(amlmUsaSGJX uslk bmU 6( X;l;slmUam xamsbus XC;  lUoX %D)
msb 
Ica; (Xsa sb ;soL6sb uLx(baLs aomsmlXn;ombmU os(Xa aomCua; saS®JD
 (u slamn;;o;slm omsluExamsb; s X;sXsa sb X(L)

BTUK fi CONNrFSANrR NUCR


RUB GBCS BONSUORBNCG
ulsowlxb;mas  m kuos lm( lsXl(a(ouslam;6aXlm(X Ummsnaxm)
0op 



	

b sXlunluuoslulF 
 aX;(lm lxUlmUnlsbmnlsbaosamsX;soXlmUsb sXlu aXX u(; ;6
;( X;smXa X amxl;;lamm aXX ; Xb(oX(a; ;am auuanco()
m; ;a (aaX
X slmlm u Xm 6amsX;snluumas o; )

aX(oX(a; ;a sbl;sXlu6sXlu;s  nluuX kl n;smXa X 
;a sb ;(lm mfaXa(sl
m Xk ;0sb  auuanlmUbXs Xl;sl;nluu X aX  aXX ; Xb(oX(a; ;3

9)  mUsba ;Ulssu;(lm %u ;lamlm mslx s X;lmuu;oi s;nbaaslm
;6m
%)  mUsba ;Ulssu;(lm 9c(a;samsX;su ;lamlm mslx s X;mfaXaXlsu9c(a;s
amsX;su ;lamlmxluulx s X;lmsba; ;oi s;nbalslamuuLX  lk Uaulmlox
amsX;s)

;lmUu X  XnluuX kl nsb 
 aXX ; Xb(oX(a; ;mnluu lm ( m msa sb sXlu)b 
X  Xnluuu;a ulm sasb slx ; To m ;a sb ;m;)
Coho(t A - 75 m  IV (N=4)
Coho(t B - 200 m  IV (N=2)
Coho(t C - 510 m  IV (N=3)
Coho(t D - 1050 m  IV (N=3)
Coho(t E - 1650 m  IV (N=5)
Pa(t II - 3300 m  IV (N=11)
0
10
20
30
40
50
60
70
80
90
Time f(om the fi()t infu)ion (month))
0
1
2
3
4
5
6

0ox 	
uu;oi s;nba lusaulmluuLX ;(amLLWlmsb s XalX sx msb; nluu 
X axx m  aX(u;x wbmU ;( X;smXa X ) m  lluX ;(am; l;U m XuuL
am;l X mlx(Xak x mslmsb ;( l l  llsC;Dsbsu sasb ba;(lsulFslam) ( mlmUam
sba; ;( l l  lls;6sb Xls XlsbsX Xaoslm uLo; sabm;	a(tlm;salmls sX sx ms
X ;(am; C;DlmxasaX6; m;aXL6osamaxlmkl;ou omslamX 3
9) mlx(Xak x mslm;sX mUsbLsb asaX ; Xbaomlu;sX mUsb;u Lsu ;s9 ouu
(almslmsu ;ssnal;aus xo;u ;a su ;sam ulx6aX
%) mlmX ; a snaL usomlmU aXtomls;lmsu ;sam    s ulx)
8) 
x(Xak x mslman umfaXu X omslam Xaxlmamslm m sasu ;s(Xslu
kauomsXLamsXau)
+) mlx(Xak x mslmkl;ouolsLo;lmU ;l m uu m Tolku msa V%ulm ;)

 ;oi s;amasX TolX  ;uslamsa(u;x wbmU  o; sb L ou luusb ulmluXls Xl
ak 6m
xL ( X aXx saam lXxX ;auoslama sb lm uxxsaXLu ;lamC;Dax(X sa
xl;;lam
); amsb 
masb Xulmlu saX;6sb sX slmU(bL;llmxL(Xa  sa
l;bXU sb ;oi sbax aXbmU sb (umsa ;us lxxoma;o((X ;;lamsa(u;x wbmU 
 aXamslmo sX sx msa sb os  w Xslam)
  aX l;bXU  Xaxsb ba;(lsu6sb ;oi snluu;b ou  aX auuano(lmsb ulml aX
sb S®m9I®Lkl;ls;)lmlmU;L
sbsxLlm uo m  ;uslamsa(u;x wbmU 
sL(luuLlmuo  ws m;lama  mbm x ms6lmkauk x msa m nX ;a sb m Xkao;;L;s xaXm
lmX ; lmsb X a %bL( Xlms m;lsL)	l;saXluuLxamUsb f(sl ms;sX s s
abm;	a(tlm;6((Xawlxs uLW®Ja f(sl ms;lx(Xak  XaxX u(; nlsb;s Xal;
uam )b asb XW®JX TolX  ;us X nlsb(u;x wbmU )

u;xwbmU X sx msb; 
baou;oi s;masx  sak ulmluXls Xlsa l;bXU bax 6 ;uslamsasX sx msnlsb
(u;x wbmU l;;smXa X )

b (u;x wbmU sX sx ms(b;  Ulm;ssb  ma sb s XalX sx msb; mnluu
u;so(sa9+L;)oXlmUsb u;xwbmU X sx msb; 6;oi s;nluuom XUa9)®r9)W
kauox ;a (u;x wbmU  k XLasb XLaXlmUsa;smXa X )ssb  ma sbl;(b; 6
; am
xL ( X aXx saam lXxX ;auoslama sb u ;lam)
 mL oXsb Xos 
lxxoma;o((X ;;lk sX sx ms aXsb os  uX l;X TolX m(Xakl aXlmUsa
;smXa X 6sb ;oi snluuamslmo sa  auuan  aX;  sLl;;o ;6ossb ulmlu   lL
snluumas lmuo lmsb ;ssl;slumuL;l;)	l;saXluuLxamUf(sl ms;
sX s ssb abm;	a(tlm;	a;(lsu6((Xawlxs uLSWJa f(sl ms;nbaax(u s 
(u;x wbmU X l;bXU  auuanlmUax(u slama sb (u;x wbmU )

u;x wbmU nluuult uLu XX xlmlmUlXouslmUoulsowlx)	an k X6Lsb slx (u;x
 wbmU l;lmlsls amLEa ba;(lsulFslam6WL; s Xsb XoUlm o;lam6xa;s6l masuu6a sb 
lXouslmU uu;nluuuX Lbk   m ulxlms ;;banmlmlUoX %)usbaoUbsb X l;ma
 w( Xlx msu(bXxatlm slslm(sl ms;nbaom XUa(u;x wbmU WL; s X
X  lklmUoulsowlx6 w( Xl m nlsbXlsowlx6;lxluX uu (u slmUU ms6o; lmsbl;
(sl ms(a(ouslam;oUU ;s;sbsos  uu (u slam(XlaXsa(u;x wbmU l;masbXx ouos
sb     sa XlsowlxxLn Xa  ;aam Xsbmlm(sl ms;nlsbaos(u;x wbmU )bl;xL 
o sa    s;a Xlsowlxaos;l a sb lXouslamC )U)6am xXXanDsbsmaXxuuLu ;saEcI
xamsb;a lXousaXL uu (u slam);nlsbXlsowlx6(u;x wbmU xLu;a;baXs msb 
oXslama lXousaXL uu (u slamo saoulsowlxlm(sl ms;)b ;     s;nluu 
xamlsaX LxamsbuL uuaoms;)



f 

b ak Xuuai slk l;sa;; ;;sb ;  sLa oulsowlx;camsb X(Lsa;s Xal; aX
sX sx msa os a(slm oXlsl;mfaXsXm;k X; xL ulsl;lmm)
fo0 


a;; ;;;  sLa os  uu (u slamlm;oi s;nlsbos X u(; a a(slm oXlsl;aX
sXm;k X; xL ulsl;nbaX sX s nlsboulsowlxH;s Xal; UlmmlmUama; 
xlml;sXslamm mlmUnlsbX (u slama lXouslmU uu;)
fof 

g
a s Xxlm sb  uu (u slam(bXxatlm sl;a oulsowlxlmsb (sl ms
(a(ouslamnlsbxamsbuL uuaoms;)
•
a s Xxlm sb (bXxatlm sl;a oulsowlxlm(sl ms;)
g
a s Xxlm sb  X To mLa k X;  k ms;nlsboulsowlxlmsb (sl ms
(a(ouslam)
•
a auuanulmlu m(alms; aX(X ulxlmXL kl m a    lL)ulmluaosax ;nluu 
xamlsaX  aX   lLo;lmUsbX   omslamum oXauaUls ;s;6sb w(m l;lulsL
sso;u CD6lx %Wcaasutm	lUbamsX;sl;ouolsLC	DoXlmU
xl;;lamsasb ba;(lsumsna auuano(kl;ls;6S®L;mExamsb; s X
ba;(lsulFslam)lslamuulmlu m(alms;nluulmuo 3
•

u ;lam;lF 
•
ox Xa L;lmba;(lsu
•
 TolX x ms aX(u;x wbmU X ;o sb X(L
g
a;; ;; aXsb     sa lxxomaU mllsLamsb (bXxatlm sl;6(bXxaLmxl;6
m;  sLa oulsowlx)







p 

po0 

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


oi s; ulUlu  aX mXauux msxo;sx  suua sb  auuanlmUXls Xl3
9) u mnluulmUsa(Xakl nXlss mlm aXx am; ms)
%) 9Ic9®®L X;a U )
8)  nos a(slm oXlsl;mfaXsXm;k X; xL ulsl;)m nulmlu k msl;  lm ;
ulmluuL;lUml lmsm oXauaUl  llsC;Dam(bL;lu wx6masssXlosu samasb Xl; ; 
(Xa ;;6nblbl;l   X ms Xax; ulm m oXauaUlu wx6mssXlosu sau ;lamlmsb 
;(lmuaX6a(slm Xk aXXlm;s x) n;Lx(sax;xo;s X (aXs nlsblm9®L;a 
am; s)
+) 	lUbuL;o;( s aXam lXx lUma;l;a aXlmUsasb %®®EX kl;lam;a sb 
lmU XbotlUma;slXls Xl aXClmU Xbot6%®®ED6aX+(a;lslk ( Xsb 
ol ulm ;)aX6;oi s;xo;sbk sna;auos Xls Xl3
) a(slm oXlsl;
) xL ulsl;
Csu ;ssnaa sbX  ;o((aXslk Xls Xl3
) (X ; m a amslUoao;;(lmuaX
u ;lam ws mlmUak XsbX  aXxaX 
k Xs Xu; Ux ms;6
) 
Xls Xl;sl; LlmUsb X kl; amulUma;slXls Xl aX
2auxm6%®99.
 ) c
UC+Dlm; Xox)
aX6;oi s;xo;sbk uamUlsolmuuL ws m;lk sXm;k X; xL ulsl;CD
X oXX msl;aus a(slm oXlsl;C
Dflus Xua(slm oXlsl;CD6aXa(sla;(lmu
xousl(u ;u Xa;l;CDsbsl;+mslaL(a;lslk 
W)
b  uuaomsxo;s maXxuCWc%®Ja sasuuLx(baLs ;Dlm;oi s;nbabk mas
X  lk masb X uu (u slmUsb X(Llmsb (;sL X)aXsba; am uu (u slmU
sb X(Lnlsblmsb (;sL X6 uuaomsa su ;s®)WJa sasuuLx(baLs ;l;m  ;;XL)
E)
  xu ;oi sl; ulUlu sa ms Xsb sXlul ;b l;3
) as(X UmmsaXmoX;lmU0
)  mamcblu XlmU(as msluCl) )nax mnbabk bbL;s X saxL6X (a;sc
x ma(o;u6nblbl;  lm ;5%L X;nlsbaosx m; ;aX6lm  xu ;oi s;nba
bk   m(a;scx ma(o;u aXq%L X;6xo;s am lXx nlsbauulu slxouslmU
	aXxam C	Dm ;sXlauu k u;D6bk asbakXl ;;oXUluuLX xak aXbk 
oXX msaox ms souulUslamD

 bluc XlmU(as msluCl) )nax mnlsb omslamuakXl ;mmaaox ms 
lx(lXx msa aklosuaXos Xlm  omslamsbsnaouo; ;s XlulsLD)bl;s UaXL
lmuo ;nax mnlsbaulUax maXXba C k m; k X D6nax mnbaX ( Xlx ma(o;u
aXbk io;s Uomsax m;sXos )ax ma bluc XlmU(as msluxo;sbk 
m Uslk ; Xox(X UmmLs ;ss;X  mlmUmUX  ;saam a sb  auuanlmU3
9) ax(u s ;slm m  Xaxlms XaoX;  aXsb ( Xla Xaxam; mslmsasb sXlu
omsluExamsb; s Xsb u;sa; a lmk ;slUslamu(Xaos0aX6

%) am;l;s msmaXX so; a am a sb  auuanlmU (su x sba;a lXsb
amsXau aXsb ( Xla Xaxam; mslmsasb sXluomsluExamsb; s Xsb u;s
a; a lmk ;slUslamu(Xaos3
) XuamsX (slk ;C lsb Xaxlm aX(XaU ;s Xam amuLD
) 
mi su (XaU ;s Xam 
)  kamaXU ;sX ulx(ums;
) ;sXaU mlkUlmuXlmU
 ) amsX (slk (sb ;
 )

msXos Xlm  kl C
DaXlmsXos Xlm ;L;s xC
Dnlsbaox ms 
 luoX Xs a q9J( XL X
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(XlaXsasb   xu ;oi sh; msXLlmsasb sXlu0sbl;xu xo;s sb ;au 
(Xsm X aXsb ;oi s
b) aou XXl Xx sba3amaxmmauo;lk (Cl(bXUxaX
 Xklufkous(;DnlsbkUlmu;( XxlluU ms
C axfU uf luxfX xf;o((a;lsaXLD)

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oi s;x  slmUmLa sb  auuanlmUXls XlX CNR ulUlu mmmas mXauulmsb sXlu3
9) oXX ms kl m aXtmanmbl;saXLa ulmluuL;lUml lmslm  slamlmuolmU3
) bXamlaXamUalmUslk lm  slao;l; ; X TolXlmUuamUs Xx;L;s xlsX sx ms
;ob;6osmasulxls sa36bXamlX mulm  slam6bXamlb ;slm  slamnlsb
Xambl s;l;6so Xoua;l;6aXslk b (slsl;)
) X klao;; Xlao;a((aXsoml;slaXsL(lulm  slam;)
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) m XlUma; ;nlsboXslama ax(u s X ;(am; CX xl;;lamD5WL X;
ABGRNKrN A FRNONTBFOBTCCr 3OU GGUL R KNFSKRBBSRBNCt
K TKO GGN K GSNCG o

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W®6®®®fxlXauls Xa uaa)
E) lUml lmsamoXX ms6omamsXauu x luamlslamlmuolmU6osmasulxls sa6Xl6
X mu6b (sl6b xsauaUlu6U;sXalms ;slmu6 maXlm 6lxxoma  ll mL;LmXax 6
(ouxamXL6 X Xu6(;LblsXl6aXm oXauaUlul; ; nblbaou   ssb ;oi sh;
;  sL6lx(lXsb ;oi sh;X ulu (Xsll(slamlmsb sXlu6lx(lXsb  kuoslama 
 m(alms;6aXm  ;;lss sb o; a x lslammasuuan Lsb (Xasaau6; s Xxlm 
Lsb 
a sb sXlu)
G) ; a mlmk ;slUslamuXoUaXasb X w( Xlx msusb X(L aXamlslamasb Xsbm
nlsblm+n  t;6W(bXxatlm slbu culk ;aXoXslama lauaUlu    s
Cnblb k Xl;uamU XD(XlaXsa;X  mlmU)
I) oXX ms(Xsll(slamlmmLasb Xlms Xk mslamuulmlusXlu)Xsll(slamlmmamc
lms Xk mslamusXluX TolX ;((Xakua sb (XasaauLlmk ;slUsaX)
S) oi s;nbaX amoXX msuLX  lklmUmLasb Xlmk ;slUslamuU ms;6aXbk 
(Xsll(s lmmlms Xk mslamuulmlusXlunlsblmsb u;s%9L;6aX;oi s;nbabk 
  mklms nlsbulk klm q%xamsb;(XlaXsasXlulmuo;lam)
9®) o; sb X l;momtmanmos(as msluXl;t aXk X;  k ms;lmmoX;lmUlm ms;
; amXLsasX sx msa sb xasb XnlsboulsowlxX ;s   lmU;baou 
l;amslmo l sb xasb Xl; mXauu )



x 


xo0 


aX Ul;s X;oi s6sb  auuanlmUaox ms;;baou ax(u s Lsb X ; XbaaXlmsaX
m;lUm Llb u kL66b)3

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lUm ulUllulsLX  mlmUaXt;b  s
•
 Ul;sXslamaXx

X) kLnluusb mk Xl L ulUllulsL)aax(u s sb X Ul;sXslam(Xa ;;6X) kLnluu3

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;;lUm;oi ssXlumox X
•
 Ul;s Xsb ;oi samsb sXlu
•
sXssb lm o;lama ;( Xsb (Xasaau

 s Xsb  lX;ssnaC%D;oi s;X  mXauu max(u s lm o;lamnlsbsXluXoUCDaX s X
sb  lX;s;lwxamsb;6nblb k Xl; lX;s6sb nluux  ssaX kl n;  sL)a oXsb X;oi s;
xL  mXauu lmsasb sXluomslusb b;X kl n sb ;soLsm;oxlss sb lX
amuo;lamsasb (am;aXm
)b nluulm aXxsb (am;aXsbssb ;soLxL(Xa  
; auuan;6saX o sb a; 6aXsas Xxlms sb ;soLo sa;  sLam Xm;;mas  uan)

 Xxls;sb Xlusaamslmo 


 sb ( Xxls;sb ;soLsaamslmo 6mlslamusbX  C8D;oi s;nluu  mXauu m
lm o; nlsbsXluXoUCD)(amax(u slama sb lm o;lama sXluXoUlmsasb ; lslamu
;oi s;6sb nluux  sUlmsaX kl nsb ;  sLs Xaxsb ; sbX  ;oi s;msb 
oxouslk ;  sL Xaxsbl;sXlu)b nluulm aXxsb (am;aXa mL;  sLam Xm;)

 Xxlms ;Xlu

b (am;aXCX) kLDxLbuu mU sbl; l;lam;( Xsb bXs X)	an k X6ma;oi s
xL  mXauu lmsasb sXluoXlmUsb buu mU )


J 
Jo0 



lk msb ; k XlsLmsb am; To m ;a X u(; lm6o; a mslk sX sx msl;am;l X 
xmsaXL)b (as mslua oXX msuLoslulF XoU;ms bmlTo ;saX o sb lm uxxslamlm
b;  m ;sul;b (XlxXluLsbXaoUb w( Xsam; m;o;m;xuua( mu um
X sXa;( slk ;sol ;)

X sx msnluu xlml;s X lmmlm(sl msba;(lsu; sslmUm;auos m osXa(bluaomsxo;s
 59®®®fOm(us u saomsxo;s 5W®6®®®fO  aX lm o;lmU)

UB OBC G NKFBCBGRKRBNCN OBRU3BF
•
Ittei(IrItigoulsowlxnluu xlml;s X ;mlmsXk mao;lm o;lam)
•
as msluXoU
ms Xslam;3aXoUlms Xslam;bk   mX (aXs sas )
o rCeIti(guu;oi s;X  lklmUmlm o;lama xo;s (X cx ls 
((Xawlxs uL8®xlmos ;(XlaXsasb a; a oulsowlxnlsbmmslbl;sxlm 
Cl(b mbLXxlm %WcW®xUaX Tolku msDmaXu sxlma(b mEW®xUCaX
 Tolku msD)
f;oi s;nluu Ulk mmlm o;lama +W®xUfLa ak X aoXC+DbaoX;
am; oslk uLamsb  lX;sLnblu ssb abm;	a(tlm;	a;(lsu)

Jof 







almk ;slUslamuaXaxx XluU ms;aXsb X(l ;asb Xsbmsba;  ;Xl  uanxL 
xlml;s X nlsbsb lms mssasX ssb ;oi sQ;os X u(; )
a;s Xal;xL xlml;s X aos;l a (XasaauX TolX x ms; aXos sX sx ms;aosulm )

C UGBNC RBNCG.BRAUOBRU3BFi
m o;lamX us X slam;bk   m X To msuLX (aXs 
nlsboulsowlx)uu;oi s;sX s nlsboulsowlxX TolX (X cx lslam((Xawlxs uL8®
xlmos ;(XlaXsasb a; a oulsowlxnlsbmmslbl;sxlm Cl(b mbLXxlm %WcW®xUaX
 Tolku msDmaXu sxlma(b mEW®xU)Lx(saxsllm o;lamX slam;6 ;(ls (X c
x lslam6xL sX s ssb l;X slama sb sX slmU(bL;llm6lmuolmUosmasulxls sa3
lslamumslbl;sxlm ;6awLU mmXambalusaX;)

Lx(saxslsX sx ms aXm oXa(sblaXxo;ouX(lmmxo;u ;(;x;xL sX s o;lmU
amaxlsmsx lslam;( X;smXa X )

Jop 
	

msb ; m a sX sx ms uL;o sak X;  k msC;D6sX sx msnluu UlmamL9nlsb
mnlsb;s Xal;amL9mamslmo saLW6omu ;;am a sb  auuanlmUXls Xl((ul ;3
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 uLlmsXm;  Xsasb abm;	a(tlm;	a;(lsu Xaxmaos;l lm;slsoslam)
msb  k mssbs
m(sl mslms X ;s lm(Xsll(slmUlmsb sXlu(X ; ms;nlsbmos X u(; sa
aos;l lm;slsoslam6sb X ;baou ma uLlm UlmmlmUsX sx msnlsb;smXa X 
;s Xalsb X(L)b ;oi sxL mXauulmsbl;sXlumX  lk am a; a oulsowlxam
sb  lX;sLa ba;(lsulFslamssb abm;	a(tlm;	a;(lsul sb sXm;  Xst ;(u 
nlsblmWL;a (X ; msslam)s XalsX sx msnluuamslmo sabm;	a(tlm;sa m;oX 
sasua WL;a ;s Xal;)

•

ms XoXX msluum ;;sbs(X k ms;xlml;sXslama sX sx ms6
•
m (su k X;  k msC;DoXlmUsb lm o;lama ;s Xal;aX6
•
oi s l ;sanlsbXn Xaxsb sXlu6aX
•
 m XuaX;( l lbmU ;lmsb ;oi sQ;amlslamX m Xsb ;oi som (su  aX
 oXsb XsX sx mslmsb ioUx msa sb lmk ;slUsaX)

b X ;am aXsXluX xakumsb s sb ;oi sn;X xak xo;s aox ms lmsb ; 
 (aXsaXx)oi s;nbal;amslmo sb X(Lo samk X;  k msnluu  auuan omslu
X ;auoslamaX;slulFslama sb k X;  k ms)

Jox 

 s Xl;bXU  Xaxsb ba;(lsu6;oi s;nluu  auuan ;maos(sl msulmluuLsL;S®m
9I®)
mlslam6;oi s;nluu xamlsaX xamsbuL aX uuaoms; aX;uamU;lsst ; aX
 uu;saX (u s saxlmlxoxa ®)WJ aX(sl ms;nbanluuamslmo sa sX s nlsbc uu
 (u slmUU ms; aX(X k mslk X 6aXlmUsa;smXa X 6aXsaxlmlxoxa WJ aX
(sl ms;nbanluuo; asb X(X k mslk ;sXs Ul ;)aXxa;s;oi s;6sb oXslama c uu (u slam
nlsbl;o(saSxamsb;)oi s;X xak  Xaxsb sXlu aXom (su k X;  k msC;Dnluu
  auuan omsluX ;auoslamaX;slulFslama sb k X;  k ms)
mlslam6;oi s;nluu 
b t Lax(u s uaaaomsnlsbl   X mslumax(u s x saul(Xa lu  aX kl m a 
sawllsLsaasb X uu;C )U)6m osXa(blu;DaXaXUm;;ob;tlm LaXulk X omslam)



V 
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;lmUu a; a +W®xUa oulsowlxnluu xlml;s X om Xsb lX slama sb Xlml(u

mk ;slUsaX6X)lb u kLnblu sb ;oi sl;lmsb ba;(lsu)
sl;X TolX sbssb ;auos 
m osXa(bluaoms 59®®®fOmsb (us u saoms 5W®6®®®O  aX sb lm o;lam)
 sb ulk X
 mFLx ;CmfaXDX 5Wslx ;sb o(( Xulxlsa maXxuCDa sb maXxuXmU ssb 
abm	a(tlm;x luuaXsaXLaXl sb m osXa(bluaomsm(us u s;aoms;X  uan
 (su u k u;; ;Xl 6sb a; a oulsowlxnluu b u aXo(sa+IbaoX;omslusb 
uaXsaXLkuo ;X soXmsanlsblm (su XmU )
 uuu;ak amasX soXmsanlsblm
 (su XmU nlsblm+IbaoX;6sb ;oi snluumasX  lk sb oulsowlxlm o;lammnluu 
nlsbXnm Xaxsb ;soL)




P 

lk msb ; k XlsLmsb am; To m ;a X u(; lm6o; a mslk sX sx msl;
am;l X xmsaXL)b (as mslua oXX msuLoslulF XoU;ms bmlTo ;saX o sb 
lm uxxslamlmb;  m ;sul;b (XlxXluLsbXaoUb w( Xsam; m;o;m;xuua( m
u umX sXa;( slk ;sol ;)

bl;l;b; 96omulm ;  sLsXlulmf;oi s;lmnblb;oi s;nluuX  lk am 
C9Dlm o;lama +W®xUa lmsXk mao;oulsowlxssb am; sa m w Xslamlmlslam
sa;smXa X sX sx msnlsbluLlmsXk mao;x sbLu(X ml;auam s9®®®xU aX lk L;)

b sXlu(b; ;moXslam;6;n uu;;smXa X sX sx msm
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X sx ms6u;xwbmU Cl m  ;;XLDX sx msmauuanc()


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%®)aXsba; nbabk X  lk  uu (u slmUx lslamlmsb (;s9%xamsb;6xlmlxox
a ®)WJa sasuuLx(baLs ;xo;s  uu;)b naXtlmUbL(asb ;l;l;sbsnb m;oi sb;m
os sst auuanlmU(X k mslk sb X(Lnlsb uu (u slmUU ms;6sb X xlmlmUaXX soXmlmU
c uu;X k XLUUX ;;lk mxLsuLF sb sst)
R KNBK RF CRAG 
	lUba; C9®®®xUDlmsXk mao;x sbLu(X ml;auam nlsb Ulk msauu;oi s;nlsb
c
am lXx slk u ;lam;sam; sa sb sstaXlmUsa;smXa X )oXlmUsb  lX;sLa 
;s XalsX sx msaX; XuL;(a;;lu lmsb ;s XalsX sx msaoX; 6+W®xUa lmsXk mao;
oulsowlxnluu xlml;s X sauu;oi s;)

  aXsnluu  ao; amUlklmUsb oulsowlx; XuLlmsb ;s XalsX sx ms(Xa ;;;
(a;;lu )
 ;oi sh;xl;;lamaXsXm;  Xsasb abm;	a(tlm;	a;(lsul; uL 6;smXa 
X sb X(Lnlsb;s Xal;nluu Ulm;;aam;(a;;lu )b ;oi sxL mXauulmsbl;sXlum
X  lk oulsowlxamsb  lX;sLa ba;(lsulFslamssb abm;	a(tlm;	a;(lsul sb sXm;  X
st ;(u nlsblmsb s XalX sx msb; )
XlaXsasb lm o;lam6ax(u s  uuaomsnlsbl   X mslumax(u s x saul(m u;X  mlmU
 aXmaXxulsl ;lmm osXa(bluaoms6(us u saomsmulk X mFLx ;)
uu;oi s;nba lusaulmluuLX ;(amLLWnluu X axx m  aX(u;x wbmU ;( X
;smXa X ) m  lluX ;(am; l;U m XuuLam;l X mlx(Xak x mslmsb ;( l l
  llsC;Dsbsu sasb ba;(lsulFslam) ( mlmUamsba; ;( l l  lls;6sb Xls XlsbsX 
Xaoslm uLo; sabm;	a(tlm;salmls sX sx msX ;(am; C;DlmxasaX6; m;aXL6osamaxl
mkl;ou omslamX 3
9) mlx(Xak x mslm;sX mUsbLsb asaX ; Xbaomlu;sX mUsb;u Lsu ;s9 ouu
(almslmsu ;ssnal;aus xo;u ;a su ;sam ulx6aX
%) mlmX ; a snaL usomlmU aXtomls;lmsu ;sam    s ulx)
8) 
x(Xak x mslman umfaXu X omslam Xaxlmamslm m sasu ;s(Xslu
kauomsXLamsXau)
+) mlx(Xak x mslmkl;ouolsLo;lmU ;l m uu mbXsa V%ulm ;)

 ;oi s;amasX TolX  ;uslamsa(u;x wbmU  o; sb L ou luusb ulmluXls Xl
ak 6m
xL( X aXx saam lXxX ;auoslama sb lm uxxsaXLu ;lam6aXlmUsa
;smXa X sabm;	a(tlm;); amsb 
masb Xulmlu saX;6sb sX slmU
(bL;llmxL(Xa  sal;bXU sb ;oi sbax aXbmU sb (umsa ;us 
lxxoma;o((X ;;lamsa(u;x wbmU  aXamslmo sX sx msa sb os  w Xslam)
lmlmU;L
sbsxLlm uo m  ;uslamsa(u;x wbmU sL(luuLlmuo  ws m;lama 
 mbm x ms6lmkauk x msa m nX ;a sb m Xkao;;L;s xaXmlmX ; lmsb X a %
bL( Xlms m;lsL)	l;saXluuLxamUsb f;oi s;sX s sabm;	a(tlm;6
((Xawlxs uLW®Ja f;oi s;lx(Xak  XaxX u(; nlsb;s Xal;uam )b 
asb XW®JX TolX  ;us X nlsb(u;x wbmU )
  aX l;bXU  Xaxsb ba;(lsu6sb ;oi snluu ;b ou  aX auuano(lmsb ulmllm
S®m9I®Lkl;ls;)
mlslam6;oi s;nluu ; mssauauu aXxamsbuL9SxamlsaXlmU
omslusb  uuaoms;X (u s saxlmlxoxa ®)WJ aX(sl ms;nbanluuamslmo sa sX s 
nlsbc uu (u slmUU ms; aX(X k mslk X 6aXlmUsa;smXa X 6aXsaxlmlxoxa 
WJ aX(sl ms;nbanluuo; asb X(X k mslk ;sXs Ul ;)b ; X ;ous;nluu X kl n Lsb 
6
X) kL)

OGF3ACT K RF CRAG 

baou;oi s;masx  sak ulmluXls Xlsa l;bXU bax 6 ;uslamsasX sx msnlsb
(u;x wbmU l;;smXa X )

b (u;x wbmU sX sx ms(b;  Ulm;ssb  ma sb s XalX sx msb; mnluu
u;so(sa9+L;)oXlmUsb u;xwbmU X sx msb; 6;oi s;nluuom XUa9)®r9)W
kauox ;a (u;x wbmU  k XLasb XLaXlmUsa;smXa X )ssb  ma sbl;(b; 6
; am
xL ( X aXx saam lXxX ;auoslama sb u ;lam6aXlmUsa;smXa X )
 
mL oXsb Xos lxxoma;o((X ;;lk sX sx ms aXsb os  uX l;X TolX m(Xakl 
aXlmUsa;smXa X 6sb ;oi snluuamslmo sa  auuan  aX;  sLl;;o ;6ossb 
ulmlu   lLsnluumas lmuo lmsb ;ssl;slumuL;l;)	l;saXluuLxamUf

;oi s;sX s ssb abm;	a(tlm;	a;(lsu6((Xawlxs uLSWJa f;oi s;nba
ax(u s (u;x wbmU X l;bXU  auuanlmUax(u slama sb (u;x wbmU )

NOON.lUS

b (XlxXLaosax l;;  sL aXsb oXslama sb ( Xlaa  uu (u slam) amXL   lL
aosax ;nluu ;; ;; s auuano(S®m9I®L; s Xlmlsluba;(lsulFslam aXsb os 
X u(; )
mlslamsasbaXaoUbbl;saXLm(bL;lu wxlmslam6lmuolmUXslmU6kl;ou
 wxlmslammslx nut6X ; Xb
a sb ;(lm nluu ( X aXx sLS®saax(X sa
sb X u(; u ;lam)
mlslam6;oi s;nluu ; mssauauu aXxamsbuL9SxamlsaXlmUomslu
sb  uuaoms;X (u s saxlmlxoxa ®)WJ aX(sl ms;nbanluuamslmo sa sX s nlsbc
 uu (u slmUU ms; aX(X k mslk X 6aXlmUsa;smXa X 6aXsaxlmlxoxa WJ aX
(sl ms;nbanluuo; asb X(X k mslk ;sXs Ul ;)b ; X ;ous;nluu X kl n Lsb 
6X) kL)

BRAK.O

aX;oi s;nbal;amslmo aXnlsbXn Xaxsb sXlu6lmk ;slUsaX;nluuamslmo saxamlsaX
;oi s;nbabk amUalmUm oXauaUl  lls;nblu sb ;oi sX xlm;lmsb ba;(lsu)bl;
lmkauk ;( Xlalm oXauaUl wx;mua; a; XkslamlmauuaXslamnlsbsb sX slmU
(bL;llm)

oi s;omu sasau Xs oulsowlxnluu nlsbXnm Xaxsb sXlu)sau XlulsLl;;o  aXsb 
(oX(a; a nlsbXnlmUsaus Xmslk sX sx msl;  lm ;xa Xs aX; k X ;l c    saX
ax(ulslamX us sasX sx ms6nblbl;om (su sasb ;oi s0aXulmluuL;lUml lms
bmU lmb xsauaUl6b (sl6aXX muuaXsaXL(Xx s X;sbs6lmsb a(lmlama sb 
lmk ;slUsaX6naouX TolX bmU lmsX sx ms)

iItitteh IrilenenrItitrIhIti

ax(u s Xl;  lm ;;oi snbab;ax(u s uua sb ulmluuLm  ;;XL(b; ;a sb 
sXlu6;( X;smXa X 6mb; auuan o(lmsb ulml aXuu auuano(kl;ls;)b 
xwlxoxoXslama (Xsll(slaml;o(saSxamsb; aXxa;s;oi s;)

Um sl ;amm 
xUlmUlmsb Xlu

b sXlunluuoslulF 
 aX;(lm lxUlmUnlsbmnlsbaosamsX;soXlmUsb sXlu aXX u(; ;6
;( X;smXa X m aXX ; Xb(oX(a; ;amS®cL auuanco()
m; ;a (aaXX slmlm 
u Xm 6amsX;snluumas o; )aXlmUsa;smXa X 6
;m;lmsb sXlunluu 
( X aXx ssb lmlslslama sb X u(; )m auuano(6sb 
l;X ; Xb(Xa oX )
aX(oX(a; ;a sbl;sXlu6;smXa X 
;a sb ;(lm nluu X kl n LsXlu;s  0sb 
 auuanlmUbXs Xl;sl;nluu X aX  aXX ; Xb(oX(a; ;3

9)  mUsba ;Ulssu;(lm %u ;lamlm mslx s X;lmuu;oi s;nbaaslm
;6m
%)  mUsba ;Ulssu;(lm 9c(a;samsX;su ;lamlm mslx s X;mfaXaXlsu9c(a;s
amsX;su ;lamlmxluulx s X;lmsba; ;oi s;nbalslamuuLX  lk Uaulmlox
amsX;s)

;lmUu ulm 
m ( m ms  XnluuX kl nsb 
 aXX ; Xb(oX(a; ;)b X  Xnluu 
ulm sasb sX sx ms;;lUmx ms;mslx ; To m ;a sb ;m;)

y 	



yo0 


s


yo0o0 OBRU3BF
e eg
oulsowlx


Ire(g
c99®96cE®8

 ((Itig
 axlmmsblx Xlmslc%®xamauamumslaL

tren Itig
  
mk ;slUsaXXaboX 

ttIti3
XU s;%®mslU mamc uu;


(rhItig
ulsowlxl;U m sluuL mUlm  X blx XlxoXlm fboxm
lX s Ulm;ssb %®mslU m aomamsb ;oX  a 
uLx(baLs ;)ulsowlxl;(uL;sb sL(lu;sXosoX a 
lxxomaUuaoulm;6am;l;slmUa snaUxxCγDb kLblm;msna
t((CκDulUbsblm;ulmt Ll;ou l XlU ;)
sl;ax(a; a 
xoXlm kXlu X UlamC8G)%Ja sasuxlmal;D o; amsaboxm
am;smsX Ulam;)

tonhh g
am msXslama 9®xUfxlm8xC8®xUDm9WxC9W®xUD;lmUu c
o; Uu;;klu;)


Itrg
saXU amlslam;

ulsowlxxo;s ;saX lm; oX ulxls c ;;X s

s x( XsoX XmUlmUH%1fHI1)ulsowlxxo;smas  XaF m)

I I g
slulsLamlslam;

m klua oulsowlxb;  ma( m mfaXluos lsxo;s 

o; lxx ls uL) s Xluoslamlm(auLklmLubuaXl CDlm o;lam
U;6oulsowlxl;;su lm;sslamlslam; aX%+baoX;s%W16m
lmLmxlamlslam;lsl;;su  aXIbaoX;s%W1)


ulsowlxb;;b u cul  a 9Ixamsb;; amkluu ;slulsL
s)

tnIt
ei(IrIti3

msXk mao;

ig
ulsowlxl;(t lmomlsaw ;)bomlsawamslm;3
•
lk 8xaXam 9WxkluC;DamslmlmU9®xUfx;auoslama 
oulsowlx
•

m;sXoslam; aXluoslamlmaloxbuaXl ®)SJ
•
s x( XsoX amsXau;L;s xlmuolmUu  u snlsblm;sXoslam;
 aXo; 


b omlsaw ;amslmlmUsb 8xkluX UXao( LWlmaos X
(tU aw ;6nblbnluu (Xakl sasb ulmlusXlu;ls ;)b omls
aw ;amslmlmUsb 9WxkluX masUXao( lmaos X(tU aw ;
msb Lnluu (Xakl lmlklouuLsasb ulmlusXlu;ls ;)


b amslm Xua;oX ;L;s xa oulsowlxl;L( 
Uu;;kluua; 
L;lulamlF XaxaosLuXo X;sa(( Xmsx( X(Xaa 
(Xas slk (Xlx( sasb m ta sb klu)

a  I g
ulsowlxl;kluu  Xaxb X( osl;

yof 	




g4
yofo0  KrNFFNC70hj
•
ONNCOrFSARBGrGR FBGNK KGi osXa( ml6bXaxaLsa( ml
•
GRKNBCR GRBCOBGNK KGio; 
•
 C KOBGNK KGCFBCBGRKRBNCGBR NCBRBNCGi k X96
m o;lamc us 
 slam;6;sb ml6bluu;
•

C  RBNCGCBC  GRRBNCGiXamblsl;6;a(bXLmUlsl;6blmlsl;6lmo;lsl;6Xub X( ;
•

CD GRBTRBNCGilmX ; 6lmX ; 6lmX ; 
•
 KDNUGGrGR FBGNK KGi	 b 
•
 GSBKRNKrtRANKBCF BGRBCOBGNK KGiaoUb
9P k XPlmuo ;(X   XX s Xx;P(LX wlPmPbL( Xsb XxlP
yofof NFFNC70jCd0hj
•
ONNCOrFSARBGrGR FBGNK KGim xl6mLsa( ml6 Xlu m osXa( ml6
osalxxom b xauLslm xl6XaLslm xl6km;;LmXax 
•
KBBGNK KGiXl uoss X6auXXbLsbxl
•
KCOrKBCRABGNK KGilmmlso;
•
CNKBC BGNK KGibLXalL;s
•
r BGNK KGiamiomslklsl;6Xlxslam X ; 
•
GRKNBCR GRBCOBGNK KGil(  x6lmUlkuu  lmU6Xu(X ;sb ;l;6saxslsl;6
;a(bUlsl;6axlmu(lm6(( Xaxlmu(lm6;sXlou X6am;sl(slam6auaml
(auL(6lk Xslouoxlms ;slmu6lXXb 
•
 C KOBGNK KGCFBCBGRKRBNCGBR NCBRBNCGib ;s(lm6slUo 6
mi slam;ls 
b xaXXbU 6 Xl(b Xu  x
•
	 SRNBOBKrBGNK KGibau ;s;l;6bau L;slsl;os 6lw ulk XlmioXL
•

FFUC GrGR FBGNK KGiXoUbL( X; m;lslklsL6	L(aUxxUuaoulm xl
•

C  RBNCGCBC  GRRBNCGi
m uo mF6omUlm  slam6(( XX ;(lXsaXLsXslm  slam6
Xb lsl;6XLmUlsl;6am;luulsl;6Xaslsl;6slsl;x l6XlmXLsXslm  slam6mu
; ;;6Xamba(ouxamXL;( XUluua;l;6 Xlu lm  slam6l;s Xla;l;6 (sl;bat6
s(bLuaau; (;l;6sX (saau; (;l;6	 (slsl;6 mlsub X( ;6	 X( ;Fa;s X6
•

CLUKrtSNBGNCBCTCSKN UKONFSOBRBNCGiXamUs bmlTo lmXoUo;U 
(Xa ;;6	 lmioXL6a;sa( Xslk b Xml6oosm ao;b xsax
•

CD GRBTRBNCGi lUbs X ; 6 Xox
UlmX ; 6%;soXslam X ; 
•
 RNOBGFCCURKBRBNCBGNK KGil s ;x uulso;lm Tos amsXau6
	L( Xbau ;s Xau xl6	L( XUuL xl6	L( XoXl xl
•
UGUONGE O ROCNCC RBD RBGGU BGNK KGit(lm6o;oua;t u su(lm6
o;u ;(;x;6LuUl6XsbXuUl6 mamlsl;
•
 NSOGFG CBTCtFOBTCCRCUCGS B B gBCOrGRGCSNOrSG4iToxao; uu
Xlmax6;u uuXlmax6 ot xl6 oXa maXlm Xlmaxa sb ;tlm
•
 KDNUGGrGR FBGNK KGiaxmau m 6X ;sb ;l6Lma( k;akUu6
;b xl;sXat 
•
GrABRKBBGNK KGimwl sL6UUX ;;lam6 (X ;;lam6
m;axml
•
 COCUKBCKrBGNK KGi	 xsoXl

•
 SKNURBD GrGR FCK GRBGNK KGi mlsu(Xau(; 6oukL;s
•
 GSBKRNKrtRANKBCF BGRBCOBGNK KGi(l;swl;6bXaslXXlsslam6
Xamba(m oxa(sbL
•
EBCCGUURC NUGRBGGU BGNK KGiXLsb x6XslXl6uu XUl Xxslsl;6
 Xlk;ouX Xxslsl;6tlmb xaXXbU 6	L( XblXa;l;6lUbs;n s;
•
GUOKBGNK KGi	L( Xs m;lam6	L(as m;lam6	as uo;b
yofop CNFFNC7ho0jCd0j
  sLs aXoulsowlxl;amuLkluu  Xaxxlml;sXslamlm88(sl ms;lmsb X  msuL
ax(u s b; 
ulmlusXlulmX u(; mX  XsaXL);;ob6o sa;ssl;slu
ulxlsslam;6maomaxxamk X;  k ms;CaoXXlmUlmV®)9Jmq9Ja (sl ms;Dm 
 ;Xl )
yofox K KBCTOBRU3BF
m sb ulmlusXlu;ls X  lk ;
f((Xakum((Xaku;m
mk ;slUsaXc
mlsls 
C(am;aXD
(X c s Xxlm TomslsLa sXluXoUCDnluu ;bl((  Xaxb X( osl;
sasb 
mk ;slUslamubXxLsabm	a(tlm;)

(amX  l(sa sX sx ms;o((ul ;6sb bXxl;saXsb ((Xa(Xls ( X;ama sb ;ls nluu
ax(u s sb tmanu U x msa X  l(sm; mlstsasb b X( osl;aX ;lUm  m
o(s sb aomslulsL aXx; aXb X( osl;)


 mLmaXxulsLamsb ;o((ul aw ;l;a; Xk 6sb bXxl;saXsb ((Xa(Xls ( X;am
xo;saox mssbsamsb tmanu U x msa X  l(s  aX ; mlmUlssab X( osl;aXls;
 ;lUm  )
yofoJ CNFBaRBNC
b X l;maXmaxlFslamlmsbl;omulm 6a( mcu u;  sL;soL)
yofoV BGS CGBCT
  aX l;( m;lmU6sb ;ls (bXxl;saXbl;fb XX (X ; msslk xo;sb tsbsoulsowlxl;lm
aXm nlsbsb (Xaos;( l lslam;msb kullsLl;nlsblmsb X cs ;sm w(lXLs )

b  wsa; msb s mslx a xlml;sXslama oulsowlxxo;s X aX nlsblmsb 
6;oi sh;x luX aX;6mfaXlmsb XoUaomslulsLX aX;)sbmox X;a 
oulsowlxxo;s X (aXs nlsblmsb )

b bXxl;saXbl;fb XX (X ; msslk nluuX aXsb s l;( m; m;oi sh;mox Xm
lmlslu;amsb u u;)	 f;b nluuax(u s sb aomslulsL aXx;nlsblm aXxslamam XmlmU
sb l;( m;slama oulsowlx)X (Xslamnluu am Lsb bXxl;saXbl;fb X
X (X ; msslk aXlmUsalm;sXoslam; aX;s Xlu luoslamlmuo nlsblmsb omlsaw ;a 
oulsowlx)luoslam aXoulsowlxl;; auuan;3


BOURBNCGN UOBRU3BF

ulsowlxxo;smas xlw nlsbasb Xx llmu(Xaos;)ulsowlx;baouamuL luos 
lm®)SJu  aX o; )asX kluu  aXasb X;auoslam;;ob;WJ wsXa; mWJ
xmmlsau)


NG N UOBRU3BF
 NKBC UGBNCgNANKR4
NOUF N 
UOBRU3BFg0h
FTvF4
NOUF N Ohobj
RN K FND 
BCODNOUF BC
S K UGBNCT
+W®xU
+Wx
+Wx
%W®x

yofoP FBCBGRKRBNC
•

xlml;sXslamamuL)ulsowlx;baoumas xlml;s X ;m
(o;baXauo;)
•
ulsowlxxo;s b t   aX  lmUxlml;s X  aXuaolm ;;6auaX6;a(L;( s6
aX (a;ls;)
•
ulsowlxxo;smas xlml;s X l a ;masam aXxsasb ;( l lslam;)b 

mk ;slUsaXaXbl;fb XX (X ; msslk xo;slxx ls uLlm aXxb X( osl;)
•

maXm nlsb slamW)9cul;sa (X cx lslamnluu xlml;s X   aX lm o;lam
a oulsowlx)
•
lm lm o;lamcX us bL(as m;lamxLaoX6CRBArS KR CGBD F BRBNCGFr 
.BRAA O%+baoX;(XlaXsamsbXaoUbaoslm o;lama oulsowlx
•
aasb XsX sx msxL acxlml;s X nlsboulsowlxCasb Xsbm aXlxx ls 
lms Xk mslam aXk X;  k msD)
•

sl;X axx m sbsoulsowlx xlml;s X lxx ls uL s Xluoslam)

ulsowlx;baou xlml;s X amuLL;uanlm o;lamkllmsXk mao;Xaos ;;lmUu 
xlml;sXslamak X aoXC+DbaoX;)

b  uanXs l;;( l l lmsb su ; uan)
yofoPo0 ON.R  NK
•
®sa8®Q3%Ja sb sasukauox 
•
8®Qsa9	3 +Ja sb sasukauox 
•
9	sa%	3 9+Ja sb sasukauox 
•
%bsa+	3
I®Ja sb sasukauox 









C UGBNCKR N UOBRU3BF
OBRU3BF
NG 
NRODNOUF 
RN BC UG 

C UGBNCKR 
hRN
ph2
phcRN0	
0	RNf	
f	RNx	
+W®xU
%W®x
9®xf	
%®xf	
8Wxf	
9®®xf	
yofoy T CR	rS KG CGBRBDBRr
OBRU3BF	rS KG CGBRBDBRrC
C UGBNC RBNCGgkluu ssb  ;l (XlaXsa
oulsowlxxlml;sXslamnluu  (lm (bXlm  aX;oosm ao;lmi slam6l(b mbLXxlm 
bLXabuaXl  aX
lmi slam6mX ;o;lsslam Tol(x ms aXsb  x XU mLxmU x msa 

m(bLuslX slam;)ulsowlx;baou xlml;s X lmsXk mao;uLsbXaoUb ls 
ulm )


b 
v


O ViA UO N D CRG


SPte
ayeeg
	sPl
oey1csyePoiego
sPlt
nPtiP
5aSPg e
c:
geaettPyl
1nn1*Td

1goSnl
sPl
i1goS
Pl





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


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

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1:oSeP::eaoesPyeP
hyPcgaotdcge
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sicgctoyPoc1g1:
oyePoiego

6eLotA/fts/7gf
,-8/tfLts/7gto7fL7oig
7frtffATiLAse:Afr:7fL




g:1yies1gtego
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nc chcncol
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escaPncto1yl
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coPntc gt*ec So
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eTy1n1 caPn5Pi
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smeytemegot

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0h

bl;l;(XlxXL;  sL;soL6osn X lms X ;s lmX aXlmU(as mslux ;oX ;a    lL)
b ; nluu ;; ;; ;; amXLulmlu m(alms;)XlxXLaosax x ;oX ; aX;  sLX 
 slu lm; slam9% uan)

  BrCSNBCRG
ulmluaosax ;nluu xamlsaX  aX   lLo;lmUsbX   omslamum oXauaUls ;s;6sb 
w(m l;lulsLsso;u CD6lx %Wcaasutm	lUbamsX;sl;ouolsL
C	D)b ; nluu ;; ;; L;9mWa ba;(lsulFslammn  tuLsb X  s X aXsb  lX;s
sbX  n  t;CL;98m%®oXlmU( Xla;m   D)
mlslam6n nluuo; Tomsl lu 

(Xx s X;;; amXL m(alms; ;Xl  uan)



b oXsFt w(m l;lulsLsso;u CDn; k ua( sax ;oX sb l;lulsL
;sso;a ;oi s;nlsbxousl(u ;u Xa;l;)
suuan;mai slk Tomsl lslama sb u k ua 
 omslamlmUsbsaou nl uLmX (XaoluLo; LX ; Xb X;mb usbX (Xakl X;)
b (Xakl ;sasu;aX am;u sbsXmU ; Xax®sa9®)b  lX;su k u;9)®sa+)WX   X
sa( a(u nlsbblUb UX  a xousaXLlulsLmsb ;o; To msu k u;W)®saS)WX   Xsasb 
ua;;a xousaXLlulsL)b XmU a xlms UaXl ;lmuo C®D/maXxum oXauaUl wx0sa
CWD/xousaXLnlsbaoslaXX ;s aX%®®x s X;0l;lulsL; k X  maoUbsalx(lX ouuluL
slklsl ;0saC9®D/ sbo sa)
mlslam6lsu;a(Xakl ; lUbs;o;u x ;oX x ms;
uu omslamuL;s xCD;aX ;)b ; ;o;u s UaXl ;X ul;s lm(( mlw%)



	lUbamsX;sl;ouolsL3	lUbcamsX;suamu ss XbXs;X X luLkluu m(Xakl 
(Xslu6Tomslsslk 6m;smXlF ;; ;;x msa kl;ou omslam)bbXsam;l;s;a Xan;
a utu ss X;C X ;lmUlm;lF  Xaxsa(saassaxDamnbls tUXaom)

aXsbl;sXlu69®®JxamaouXblUbamsX;skl;ouolsLnluu x ;oX amL;9mWoXlmU
sb ;s Xal(b; mn  tuLoXlmUsb (u;x wbmU (b; )bXs;nluu X s%cx s X
l;sm LsXlm  wxlm X;lmsb ba;(lsuXaaxnlsbam;smsulUbslmUa I®c9®® aascmu ;
ax(ul;b o;lmU;smX uoaX ; msba;(lsuXaaxak Xb ulUbslmU)lmaouXs ;slmUnluu 
X aX ;sasumox Xa u ss X;l msl l aXX suLCxwlxoxE®D)

eBsCttI 

lx %Wc aasnutlmUsXlu;nluu ;; ;; amL;9mWoXlmUsb ;s Xal(b; mn  tuL
lmsb (u;x wbmU (b; )b lx %Wcaasuts ;sl;Tomslsslk x ;oX a uan X
 wsX xlsL omslam)
 X TolX 6sb ;oi sxLo; m((Xa(Xls ;;l;slk  kl sanut;
ToltuL;b f;b m Xaxam  msasb asb X ma u XuLxXt 6oma;sXos 6%Wc aas
aoX; )k XL   aXsnluu x sao; sb ;x s ;slmUbuunL aX k XLlx %Wcaasut
s ;s)as mslu aX ws Xmul;sXslam;;baou t (ssaxlmlxox;xob;(a;;lu );oi s
nluu;smnlsbsb sa ;a bl;fb X;ba ;amsb ;sXslmUulm Cl msl l Ls( xXtamsb 
 uaaXDmslxlmUnluu Ulmnb mmL(Xsa sb ;oi sQ; aasXa;; ;sb s( )lxlmUnluu m
nb mmL(Xsa sb ;oi sQ; aasXa;; ;sb  lml;bulm Cl msl l Ls( xXtamsb  uaaXD)
lx nluu X aX lm; am;mXaom sasb m X ;ss msba ; amo;lmU;sa(nsb
(Xakl  aXsbl;sXlu)b s;tl;lxx ls uLxlml;s X UlmLbklmUsb ;oi snutt
sb ;x l;sm )b k XU a sb snakuo ;nluu X aX lmsb ; X (aXs aXx)

L RBD   BrCSNBCRG


;nluu ( X aXx  aX;smXa X mX ; Xb(oX(a; ;mnluu o; saxt 
ulmlu l;lam;aos ;uslama lxxoma;o((X ;;lk sX sx ms)aXsbl;sXlu6sb 
;nluu
u;a muLF  aXsna(Xx s X;3u mUsbm%bL( Xlms m;lsLlmsb ;(lmuaXma(sl
m Xk mu mUsba 9(a;scamsX;s mbm x msl kluu )

ox Xa L;lmsb ba;(lsumX TolX x ms aX(u;x wbmU nluuu;a X aX amsb 
;)
0ho0




CR CRlRNlK Rouu;oi s;nbaX  lk am a; a sXluXoUnluu lmuo lmsb lms mscsac
sX sUXao()

 KlKNRNNOouu;oi s;nba( X aXx uukl;ls;lmaXm nlsb(Xasaaunlsbaos;lUml lms
(Xasaau klslam;aXklauslam;)

OOUL RK RF CRKNUSouu;oi s;nbaX  lk am a; a sXluXoUCD)



00




bl;; slam ;Xl ;sb ;ssl;slux sba;sa o; samuLF sb    lLm;  sL
 m(alms;) aXxu;ssl;slumuL;l;(umCD6nblbxo;s  lmulF   aX s; uat6
nluu(Xakl lslamu slu; aXsbmulmU(Xa oX ;6;ssl;slux sba;6ms
(X ; msslam;C )U)6su 6ul;slmU6m lUoX ;b uu;D)b  lmuulmlu;soLX (aXsnluu ;Xl 
 klslam; Xaxsb 6l mL)
00o0

	rSNRA GBG
bl;sXlul; w(uaXlmUsb ;  sLa oulsowlxlmsb sX sx msa fX u(; ;)b 
bL(asb ;l;l;sbssb oulsowlxX Ulx m(Xa(a; lmsbl;sXlul;;  msau Xu lmsb 
f(sl ms(a(ouslam)b ai slk ;a sb sXlunluu ;; ;; sbXaoUbsb o; a 
;oxxXL;ssl;sl;)

FSO Ba NCGB KRBNCG
b ;x(u ;lF a W;oi s;l;; am  ;llulsLmuaUl;sluam;l Xslam;amsb mox Xa 
;oi s;sbsnluuX k u;lUml lmsXl;taXsau XlulsLl;;o a o;lmUoulsowlxH;s Xal;)
sl;
msll(s sbs9;oi snluu lu;X  mlmUm9nluuXa(aosak Xsb aoX; a sb sXlu6 aX
sasua +;oi s;nbaX  w( s saax(u s sb sXlu)oi s;nbanlsbXnnluumas 
X (u )
00of



CR KBFCOrGBG

b X nluu malms XlxmuL;l;)

RRBGRBOCOrGBG

;oxxXLa sb mox Xm( X msU a ;oi s;nlsbmLk X;  k ms6mL; Xlao;k X; 
 k ms6k X;  k ms;u lmUsa( Xxm msl;amslmoslama sXluXoU6msXluXoUcX us 
k X;  k ms;nluu X (aXs )

bmU lmm oXauaUlaosax ;amsb 6lx %Wcaasutm	;u ; Xaxxl;;lam
sal;bXU nluu muLF L(lX scs ;s;nlsb;lUml lms(ckuo ;am;l X u ;;sbm®)®W)

L
6u mUsba %bL( Xlms m;lsLmu mUsba 9c(a;samsX;s mbm x ms;baou ;su 
aXX o Ll;bXU )(lX scs ;snluu o; saax(X bmU ;lmsb ; kuo ;nlsb
;lUml lm am;l X s(ckuo ;u ;;sbm®)®W)

amslmoao;snluu  ;Xl o;lmUsb  auuanlmU ;Xl(slk ;ssl;sl;3m6x m6x lm6
xlmlxoxmxwlxox)snluu l;(uL lmuuul;slmU;;aXs L;oi smox X)

b maomssX (X ; ms 6sb ( X msU nluu ;o((X ;; nb msb aomsl;F XalmaX X
saXnss mslamsasb mamcF Xaaoms;)Xan mas pl;;lmUenluu lmuo lmaoms
souslam;nb X m  ;;XLsaaoms aXXa(aos;mxl;;lmUkuo ;)mu ;;asb Xnl; 
;( l l 6sb  maxlmsaX aX( X msU ;nluu sb mox Xa ;oi s;nlsbmamcxl;;lmU
;; ;;x msnlsblmsb muL;l;(a(ouslama lms X ;s)

 X;lamS)%nluu o; sa( X aXxuumuL; ;)

00op


b 
ms mscsacX sC
D(a(ouslamnluuo;  aXsb a  llumuL;l;)

b   sLa(ouslamnluulmuo uu;oi s;nbaX  lk am a; a sXluXoUCD)uu;  sL
;; ;;x ms;lmuolmUsawllsLnluu ( X aXx amsb   sLa(ouslam)

b  XcXasaaua(ouslamCDnluuam;l;sa uu
;oi s;nlsbaosxiaX(Xasaau klslam
aX(Xasaauklauslam)b Xls Xl aXxiaX(Xasaau klslamaXklauslamnluu  s Xxlm m
aox ms (XlaXsas; uat)oi s wuo;lam Xaxsb (a(ouslamnluuu;a 
 s Xxlm maox ms (XlaXsas; uat)o((aXslk muL; ;xL ( X aXx ; 
amsb (a(ouslam)
00ox



b l;(a;lslama ;oi s;lmuo ;sb mox Xm( X msU a ;oi s; aXsb  auuanlmU
s UaXl ;3;oi s;sX s C;  sL(a(ouslamD6;oi s;lmsb 
(a(ouslam6;oi s;ax(u s 6
m;oi s;l;amslmo  Xaxsb sXlu)uu( X msU ;nluu ; amsb mox Xa ;oi s;
 mXauu )b X ;am; aXsXlul;amslmoslamnluuu;a ;oxxXlF lmsbl;su )muLam 
X ;am aXsXlul;amslmoslamnluu X aX )	an k X6uuX ;am;nluu (X ; ms lmsb 
ul;slmU)

ul;slmUnluu(X ; mssam XmlmU;oi sl;(a;lslam)
00oJ	

	


; ulm  xaUX(blmulmlubXs Xl;sl;nluu ;oxxXlF ;( X msU ; aXs UaXlu
kXlu ;m;x m6;smX klslam6x lm6xlmlxoxmxwlxox aXamslmoao;
x ;oX ;)b muL; ;a ; ulm bXs Xl;sl;nluu ( X aXx  aXsb 
a(ouslam)
00oV




XlaXmamaxlsmsx lslam;nluu ;oxxXlF  aXsb   sL(a(ouslamLaXu	 usb
XUmlFslamC	Dm lslamXL)oi s;xLbk xaX sbmam x lslam( X
XoUu;;m(X   XX s Xx)s bu k ua ;oxxXlFslam6;oi sl;aoms am l b f;b 
X (aXs am aXxaX x lslam;ssbsu k u)

XlaXx lslam;X   lm ;x lslam;nlsb;sa(s aoXXlmU  aX sb s a X  lklmU
 lX;ssXlusX sx ms)amaxlsmsx lslam;X   lm ;x lslam;nlsb;sXss ;
aoXXlmUamaX s Xs a X  lklmU lX;ssXlusX sx ms) lslam;nlsb;sXsm;sa(s ;
nblbXt ssb s a  lX;sa; nluu ;oxxXlF ;asb(XlaXmamaxlsmsx lslam;)
00oP
	

 lubl;saXLnluu (soX ssb X  mlmUkl;ls) lubl;saXLnluu a o;lmU 
mnluu ;oxxXlF L ;L;s xaXUmu;;m(X   XX s Xx aXsb   sL
(a(ouslam)
00oy
b a; CxUDa sXluXoUxlml;s X CD6msb oXslama sX sx msnluu ;oxxXlF 
nlsb ;Xl(slk ;ssl;sl;)b (Xa(aXslama ;oi s;ax(u slmUsb lm o;lama sXluXoUCD
nluu ;oxxXlF )

00ob

 amXL m(alms;a ulmluaosax ;nluu xamlsaX  aX   lLo;lmUsbX   omslamu
m oXauaUls ;s;6sb w(m l;lulsLsso;u CD6lx %Wcaasutm	lUb
amsX;sl;ouolsLC	D)b ; nluu ;; ;; L;9mWa ba;(lsulFslammn  tuL
sb X  s X aXsb  lX;ssbX  n  t;CL;98m%®6l m   D)b (XlxXLmuL;l;nluu 
bmU  Xax; ulm saLS®msb ; amXLmuL; ;nluu bmU  Xax; ulm saL;
W6%®6mExamsb;)

aXsbl;; amXL   lL m(alms6sb 
;nluu muLF  aXsna(Xx s X;3u mUsba %
bL( Xlms m;lsLlmsb ;(lmuaXma(slm Xk mu mUsba 9(a;scamsX;s mbm x msl 
kluu )b ; amXLmuL; ; aX
nluu bmU  Xax; ulm sal;bXU amLWaX
%®6;n uu;bmU  Xax; ulm sa auuano(sLS®)

ox Xa L;lmsb ba;(lsumX TolX x ms aX(u;x wbmU nluu ;; ;; o;lmU
 ;Xl(slk ;ssl;sl;)







0f


0fo0
  sL kuoslam;nluu ; amsb lml m 6lms m;lsL6msL( a k X;  k ms;6;n uu;
amulmluuL;lUml lmsbmU ;lmsb ;oi sh;(bL;lu wxlmslam6klsu;lUm;6mulmlu
uaXsaXLX ;ous;)  sLmuL; ;nluu ( X aXx o;lmUsb ;  sL(a(ouslam)  sLkXlu ;
nluu sous m(X ; ms )w(a;oX sasXlusX sx msmX ;am; aXl;amslmoslama 
sXlusX sx msnluuu;a sous )
0fof
k X;  k msCDxamlsaXlmUmX (aXslmUl;Xaoslm (Xsa  k XLulmlusXlu)b  auuanlmU
ul;sa ;msb bXs Xl;sl;a ma; Xk C slamI)%Dnluu s Xxlm nb sb Xsb  k ms
X TolX ; w( ls X (aXslmUlmlslamsaXaoslm X (aXslmU)
0fop	


R KFg GKBSRBNC4CTK ib  ;Xl(slam;mUXlmU;u ; aomlmsb 
X kl; 
axxam XxlmauaULXls Xl aXk X; k ms;CDk X;lam+)®nluu oslulF 
 aXX (aXslmU)uu((Xa(Xls sX sx msX ;;baoubk  ;;saa(La sb 
k X;lam+)®)a(La sb k X;lam+)®m anmua  Xaxsb n ;ls 
bss(3ffs ()m X)Uakf(Xasaau k ua(x msf u sXamlA((ulslam;fs)bsx)

e3S R C GG2i;m ym w( s haXyw( s h aX w( ls X (aXslmU(oX(a; ;amuL)

0foxl






b X X ma wuo;lam; aX w( ls k X;  k msX (aXslmU)uuk X;  k ms;6lmuolmU sb6
nluu am;l X om w( s m;oi ssa w( ls X (aXslmU)
0foJ
uu;m;aoXXlmUamsXlunluu ul;s L;oi s)b  X To mLm( X msU ;a 
;oi s;nlsbsX sx msc x XU msk X;  k ms;C;Dnluu sous L;L;s xaXUmu;;
CDm6nb X sX sx msc x XU msl;  lm ;mLsbs3

•
oX; s X lX;sa;lmUa sXlux lslammsbXaoUbsb  ma sb sXluaXo(sbXaoUb
8®L; s Xsb u;sa; a sXlusX sx ms6aX
•

;am;l X sX sx mscX us X UXu ;;a sb ;sXss a sb  k ms6aX
•

;(X ; ms  aX  lX;sa;lmUa sXlux lslamosnaX; m;lmlms m;lsLaXsb lmk ;slUsaX
;o; To msuLam;l X;sX sx mscX us )

;sbsX am;l X su ;s(a;;luLX us sasXlusX sx msnluu sous ;n uu;
 sb;6;6m k ms;X ;ouslmUlmsX sx msl;amslmoslam)

;sbsaoX s Xlm aXx am; msos  aX  lX;sa;lmUa sXlux lslamnluumas 
;oxxXlF osnluu ul;s )

s bu k ua ;oxxXlFslam6;oi snluu aoms amuLam  aX b66aX
 w( Xl m nlsblmsbsu k u)
msb ;oxxslam aX; k XlsL6nlsblm bu k ua 66aX
 w( Xl m 6sb am nlsbsb blUb ;s; k XlsLnluu lmuo )
msb ;oxxslam aXh;

X uslam;bl(sasb sXluXoU6nlsblm bu k ua 66aX w( Xl m 6sb am nlsbsb 
ua; ;sX uslam;bl(sasb sXluXoUnluu lmuo )
0foV



mk X;  k msCDl;mLomsanXx luaoXX m lm;oi saXulmlulmk ;slUslam
;oi sxlml;s X (bXx oslu(Xaos)ma ;masm  ;;XluLbk sabk o;u
X uslam;bl(nlsbsbl;sX sx ms)mk X;  k msCDmsb X  aX  mLom kaXu m
omlms m ;lUmClmuolmUmmaXxuuaXsaXL lmlmU6 aX wx(u D6;Lx(sax6aXl; ; 
s x(aXXluL;;als nlsbsb o; a x llmu(Xaos6nb sb XaXmasam;l X X us sa
sb x llmu(Xaos)bl;lmuo ;mLaoXX m sbsl;m nlmam; saXUUXks lm; k XlsL
aX X To mL Xaxsb ; ulm amlslam)


mulmlu;sol ;6mmlmuo mom ;lXu x luamlslamaoXXlmUsmLslx 6
lmuolmUXomclmaXn;baos( Xla;6 k ml masXlusX sx msb;  mxlml;s X )b 

axxam XxlmauaULXls Xl aXk X; k ms;CDk+)®l;sa o;  aXsb UXlmUa 
; k XlsLa ;Lx(sax;mmaXxu lmlmU;)aXk X;  k ms;masak X Lsb 
c
 X;lam+)®UXlmU;L;s x6sb  auuanlmU  lmlslam;nluu o; 3

•
K 03lu0;Lx(saxslaXxlu;Lx(sax;0ulmluaXlUma;sla; Xkslam;amuL0
lms Xk mslammaslmls )
•
K fia Xs 0xlmlxu6uauaXmamclmk;lk lms Xk mslamlmls 0ulxlslmUU c
((Xa(Xls lm;sXox msu,)
•
K p3 k X aXx luuL;lUml lmsosmaslxx ls uLul  csbX s mlmU0
ba;(lsulFslamaX(XauamUslama ba;(lsulFslamlmls 0l;ulmU0ulxlslmU; u cX 
,,
•
K x3l  csbX s mlmUam; To m ;0oXU mslms Xk mslamlmls )
•
K J3 sbX us sa)

b 
mk ;slUsaXxo;su;a;; ;;sb X uslam;bl(a mLk X;  k mssasb o; a sXluXoU6
; amkluu lm aXxslam6o;lmUsb  auuanlmUUol ulm ;3

•
NR OR 3u Xcoss x(aXumfaXx bml;slX uslamsao; asb Xsbmsb sXlu
XoU)
•
NUR UO3b X l;maX ;amu (a;;llulsLsbssb  k msl;X us sasb sXluXoUos
  lmls o; mmas ; Xslm )
•
NGGBO 3b X l;;sluuX ;amu (a;;llulsLsbssb o; a sb  k msn;sb sXluXoU
ossb X  wl;s;xaX ult uLo; a sb  k ms;ob;ax(ulslam;a (XaUX ;;lk 
l; ; )
•
KNO 3b xa;sult uLo; a sb  k msl;sb sXluXoUosasb Xo; ;mmas 
ax(u s uL wuo )
•
  BCBR iu Xoss x(aXumfaXx bml;slX uslamsasb sXluXoU)uuasb Xo; ;
bk   m ulxlms )k ms;u;;l l ;  lmls nluua s m am lXx Laox mslmU
X ;auoslamaml;amslmoslama sb sXluXoUmX oXX m o(amX ;ox(slam)
0foVo0  NKBCTN D KG D CRG
uuk X;  k ms;a mL;oi soXlmUsb aoX; a sb sXlunluu X (aXs amsb ; X (aXs
 aXx6msb lmk ;slUsaXnluuUlk bl;aXb Xa(lmlam;sasb X uslam;bl(a sb k X;  k mssa
sXluXoUsX sx msCl) )6nb sb Xsb  k msl;X us aXomX us sasXluXoUxlml;sXslamD)
 
sb k X;  k msl;; Xlao;6ls;baou X (aXs ;;aam;(a;;lu mmaUX s Xsbm%+baoX;

sab X( osl;msb blXa )b abm;	a(tlm;
xo;su;a masl l ;
X TolX Labm;	a(tlm;
Uol ulm ;)sb XomsanX k ms;aoXXlmUlmsb  Xx naXta 
ulmlusXluX u;asa X aX ;;Cl) )6;sbsaoX(XlaXsa;;lUmx msa sXlu
sX sx mssbsX X us sa(Xasaaucxms lms Xk mslam6lmuolmUlmk;lk (Xa oX ;;ob
;la(;l ;6x lslamn;baos6aXmasX sx msXomclmD)

uu;X UXu ;;a ; Xlao;m ;;aXX uslam;bl(saoulsowlxsX sx ms;(mmlmU Xaxsb 
;lUmsoX a sb lm aXx am; ms aXx6omslu8®u mXL; s Xl;amslmoslamaXax(u slam
a (Xasaauc;( l lsX sx ms;  lm Lsb (Xasaau aXsbs;oi s6X sa X aX amsb 
)
0foVof CNKFONKRNKrOU GCBROBTCG
b X (aXslmUa maXxulsl ;a klsu;lUm;;k X;  k ms;;baou kal )maXxulsl ;a 
klsu;lUm;;baoumas X (aXs omu ;;mLXls Xlam aXml; ou luu 6sb klsu;lUm;
maXxulsl ;o; sb ;oi ssal;amslmo sXlusX sx ms6aXsb lmk ;slUsaXlm;l;s;sbssb 
maXxulsL;baou X (aXs ;m)mLUX 8aX+uaXsaXLmaXxulsLaXmLulmluuL
;lUml lmsUX 9aX%b xsauaULaXlab xl;sXLuaXsaXLkuo C;D;baou X aX ;m
)
 mmaXxuuaXsaXLkuo aXklsu;lUml;;;als nlsbulmlu;lUm;mfaX;Lx(sax;6
sb ;lUmaX;Lx(sax;baou X (aXs ;m6msb ;;als uaXsaXLkuo aXklsu;lUm
;baou am;l X lslamulm aXxslamsbsxo;s auu s amsb X u kms)

ulmluaXsaXL ;ous;nluu ;oxxXlF )oxxXL;ssl;sl; aXsoukuo ;m aX
bmU ; Xax; ulm nluu sous  aXuaXsaXLX ;ous;L;b ou kl;ls)oi s;nlsb
uaXsaXLkuo ;aos;l a sb maXxuX   X m XmU smL(a;sc; ulm ;; ;;x msnluu 
;oxxXlF 6mUX ( X
 X;lam+)®nb m((ulu )oi slml m a 
uaXsaXLsawllsLnluu ;oxxXlF m;;lUm xwlxoxUX  aX buaXsaXLs ;s)
0foVop 	COBCTN D KG D CRG
uuk X;  k ms;X ;ouslmUlml;amslmoslam Xaxsb sXlu;baou  auuan omsluX ;auoslamaX
;slulFslam)oi s;xo;s  auuan  aX; aX8®u mXL; s Xl;amslmoslamaX
ax(u slama (Xasaauc;( l lsX sx ms)uum n;aoXXlmUoXlmUsbl;( Xlaxo;s 
X (aXs m auuan omsluX ;auoslamomu ;;6lmsb a(lmlama sb lmk ;slUsaX6sb ; kuo ;X 
masult uLsalx(Xak  o; a sb om XuLlmUl; ; )
msbl;; 6sb lmk ;slUsaX;xo;sX aX
bl;aXb XX ;amlmU aXsbl; l;lamlmsb ;oi sh;x luX aXm;axx msamsb )
 s X8®L;6amuL;6;6aX sb;;; ;; Lsb lmk ;slUsaX;sX sx msX us X sa 
X (aXs )
0foP

0foPo0   BCBRBNCGN  KBNUGD KG D CRG
b   lmlslam;a ; Xlao;k X;  k ms;C;DX Ulk m uan)b (Xlml(ulmk ;slUsaXl;
X ;(am;lu  aX m;oXlmUsbsuu;s  lmkauk lmsb sXlul; xlulXnlsbsb ams msa sbl;; slam)

maXX slaml;  lm ;mLomsanXx luaoXX m sbs3
•
X ;ous;lm sb6l;lxx ls uLul  csbX s mlmU6
•
X TolX ;su ;s%+cbaoXlm(sl msba;(lsulFslamaX(XauamUslama  wl;slmU
ba;(lsulFslam6
•
X ;ous;lm( X;l;s msaX;lUml lmsl;lulsLflm(lsL6
•
o; ;amU mlsumaxuLflXsb   s)

 lum;l msl lioUx ms;baou  w Xl; lm llmUnb sb X w( ls X (aXslmUl;
((Xa(Xls lmasb X;lsoslam;6;ob;lx(aXsmsx lu k ms;sbsxLmas lxx ls uLul  c
sbX s mlmUaXX ;ouslm sbaXba;(lsulFslam6osxLi a(XlF sb ;oi saXxLX TolX 

lms Xk mslamsa(X k msam a sb asb Xaosax ;ul;s lmsb (X klao;  lmlslam)b ; ;baou
u;ao;ouuL am;l X ; Xlao;)wx(u ;a ;ob k ms;X lms m;lk sX sx mslmm
 x XU mLXaaxaXsbax  aXuu XUlXamba;(;x0uaaL;X;l;aXamkou;lam;sbsamas
X ;ouslmba;(lsulFslam0aX k ua(x msa XoU ( m mLaXXoUo; ) sbo sal; ; 
(XaUX ;;lamnluu X aX amsb )l;  lm ;;o;( s om w( s 6m
X (aXslmUl; max(;; nlsblmX (aXslmUUol ulm ;;  lm lmsbl;; slam)

X sx msnlsblmaXxl;;lamsasb  auuanlmU lulsl ;l;masam;l X sax  ssb Xls Xla 
plm(sl msba;(lsulFslameCusbaoUbl mLasb XXls XlX x s6sb  k msxo;s;sluu 
sX s ;mmlxx ls uLX (aXs D3

•
x XU mL (Xsx msaXx XU mLaax
•
os(sl msaX;x cL;oXU XLomls;
•
; XkslamaX;baXsc;sLomls
•
 blulsslam lulsL
•
	a;(l aX;tluu moX;lmU lulsL
•
oX;lmUbax ;6o;saluX aX ;(ls X  lulsL

	a;(lsulFslamoXlmUsb sXlu aX(X c(umm ;oXUluaXx lu(Xa oX Cam nblbn;
(umm (XlaXsa msXLlmsb sXluDa ;masX TolX X (aXslmU;; Xlao;k X;  k mssasb 
(am;aXCX)lb u kLD)
0foPof  KBNUGD KG D CR SNKRBCTr
CD GRBTRNKG

sl;lx(aXsmssal;slmUol;b sn  mp; Xlao;emp; k X ek X;  k ms;6;sb s Xx;X mas
;LmamLxao;) k XlsLl;x ;oX a lms m;lsL0ban k X6ma ; k X lms m;lsLm  mas
m  ;;XluL am;l X ; Xlao;)aX wx(u 6mo; 6nblb( X;l;s; aX; k XubaoX;6xL 
am;l X ; k X mo; 6osxLmas am;l X m)msb asb Xbm6;sXat nblb
X ;ous;lmamuLulxls  UX  a l;lulsLxL am;l X amuLxlu;sXat 6osnaou 
am;l X m) k XlsLm; Xlao;m ;;;baou lm ( m msuL;; ;; nb mX aXlmU
;m;amsb )

k X;  k ms;u;;l l Lsb sX slmUlmk ;slUsaX;G KBNUGX TolX  w( lslao;bmulmUm
X (aXslmUsasb 
aXasb XX UousaXLU ml ;lmaX Xsaax(uLnlsbX UousaXLX TolX x ms;)
 Xlao;k X;  k ms;xLaoXsmLslx  Xaxsb ;lUmlmUa sb lm aXx am; ms aXx
sbXaoUbsb Scxamsb auuanco(( Xla s Xsb u;ssXlusX sx ms)(am;aXaX ;lUm  xo;s 
masl l a uu;6X UXu ;;a o;ulsL6nlsblm%+baoX;a sb  lX;stmanu U a sb  k msL
sb sX slmU(bL;llmaXX ; Xb( X;amm u)

NK SNKRCtG  RA SSKNSKBR ST o
uu;mx luuLam lXx  sb;CX UXu ;;a o;ulsL;; ;;x msDaoXXlmUamsXlu
sX sx msaXnlsblm8®L;a u;ssXlusX sx msxo;s X (aXs sasb b X( osl;6sb 
abm;	a(tlm;
msb blXa sb ;;nlsblmsb m auuan omsluX ;auoslam
Cnlsbosa(;LX (aXsl ((ulu D)

 sb;aoXXlmUnlsblm8®L; s Xu;ssXlusX sx mssbsX   x y(a;;luLhaXy(XauLh
X us saoulsowlxxo;s X (aXs ;;nlsblmsb Cnlsbmosa(;LX (aXsl 
kluu D)

 sb;aoXXlmUnlsblm8®L; s Xu;ssXlusX sx msmmasssXlos sasXlusX sx ms
C )U)6l; ; (XaUX ;;lamDm  mas X (aXs lmm w( lslao;xmm Xsasb b X( osl;
msb blXa sb 6osm;lx(uL (soX amsb ((Xa(Xls ;mC sbD)
b abm;	a(tlm;
;baou masl l ;;aam;(a;;lu )


b lmk ;slUsaXxo;sX kl nm;lUma  amsb samsb X (aXs)b nluu 
X (aXs sasb (am;aXCaX(am;aX ;lUm  D;aosulm lmsb   sLamlsaXlmUum)


 ml;X (aXs sasb ;(am;aXaX ;lUm  kl w6sb ;x lm aXxslamxo;s  ms X am
sb nlsblm%+baoX;C9o;lm ;;LD)Xm;xl;;lama sb X (aXs;baou am lXx L
sb ;ls ( X;amm u;oxlsslmUsb X (aXs)

auuanco(lm aXxslam aX;mlm aXxslamammamc; Xlao;;sbs ax ; Xlao;;baou
u;a X (aXs sasb ;(am;aXaX ;lUm  ;;aam;lsl;kluu 0sb ; X (aXs;;baou 
;oxlss o;lmUsb ((Xa(Xls )b  slu X (aXslmU(Xa ;;nluu (Xakl sasb 
;ls ;lmsb   sLamlsaXlmUum)


mk ;slUsaX;xo;sX (aXs;m auuanco(lm aXxslamsasb lXX ;(am;lu 
m;slsoslamu kl n
aXC
;Df
m ( m mssbl;axxlss  aXlmUsasb (aull ;a sb X ;(am;lu 

C ; Xbsbl;axxlss  D)
0foy


b (am;aXCX) kLDnlsb;;l;sm  Xaxb X( osl;X X ;(am;lu  aXX (aXslmUX u kms
;sasb ax( s msosbaXlsL6asb X((ulu X UousaXLosbaXlsl ;6m(Xsll(slmU
lmk ;slUsaX;6lmaXm nlsb
	Uol ulm ;6X Uouslam;6mfaXuauX UousaXL
X TolX x ms;)

b (am;aXCX) kLDnlsb;;l;sm  Xaxb X( osl;X X ;(am;lu  aXX (aXslmU
om w( s  suaXul  csbX s mlmU k ms;;;als nlsbsb o; a sb sXluXoUsasb 
X UousaXLU ml ;max( s msosbaXlsl ;kls u (bam aX wnlsblmGu mXL; s X
 lmUmasl l a sb  k ms)b (am;aXnluuX (aXsuuX us osom w( s ;lmuolmU
mamc sbfmamcul  csbX s mlmUX us osom w( s ;;;als nlsbsb o; a sb sXlu
x lslamsab X( osl;msb abm;	a(tlm;
;L;  sLX (aXsnlsblm9+u mX
L;a masl lslam)b X( osl;l;X TolX samasl Lsb )
0fob



mk ;slUsaX;nluuo; aXX sx lus XxlmauaULfam (s;nb mX aXlmU;aX;amsb 
 (aXsaXx;m)auuaTolul;x;mX klslam;nluu kal )

uu;6lmuolmUsba; sbsx  sX (aXslmUXls Xl6nluu X aX amsb 0;sbs
x  ssb   lmlslama mnluulslamuuL X (aXs  auuanlmUsb (Xa oX ;mas lm
 slam9+)G)
0fo0h


	


0fo0ho0
AKFNEBC RBg4FSOBCTi
sl ms;nluubk (bXxatlm slCD;x(ulmUC; XoxD( X aXx ;mas amsb ;b ou 
 uan3
BF SNBCR
X ca; 
9xlm(XlaXsa

8®xlm(a;s
9
EbaoX(a;s
%

%+baoX(a;s
8
G%baoX(a;s
8
9EIbaoX(a;s
8

3ma 
m o;lam
9HfcWxlmos ;
%Hfc8®xlmos ;
8Hfc%baoX;

x(ulmUXa oX ;c

sa(m;sXsslx ;a lm o;lamxo;s X aX msouslx fs ;a ;x(u ;Xnm
xo;s (Xakl )b ;oi snluumasX  lk mLlslamulm o;lam;a oulsowlx)
uu;x(u ;sa aslm  aXmuL;l;a oulsowlxnluu ; Xox)m Ecxuuaa;x(u l;
X TolX  aX b;x(u slx (alms)
 s X msXl oUslam6%ulToas;a ®)Wxua ; Xox;baou ;saX sc%®1saG®1ssb ;ls )m 
ulToasnluu ; mssab X( osl;msb ; amulToasnluu ;bl(( sab X( osl;
 s Xsb  lX;s;x(u l;X  lk Lsb x)uu;x(u ;xo;s ; msnlsblm9+L;a  lmU
auu s  Xaxsb ;oi s)
((Xawlxs uL; k mCGD;x(u ;ak XGL;;baou auu s  aXsb muL;l;a 
oulsowlx)

0fo0hof
FSO NOO RBNCCKN GGBCTi
)  Xl(b Xuuaal;sa Xnmlmsab (XlmlF koslm Xso ;)b (sl msh;lmlslu;6
slx ;x(u aslm 6ms ;x(u n;aslm ;baou X aX am bso 
;n uu;amsb X ;( slk slx ;b  slmsb )
) lsblm%®xlmos ;a auu slam6 msXl oU sb uaa;x(u ;sS®®wU aX9Wxlmos ;sa
; (Xs (u;x)
) aX b;x(u auu s 6(l( ss o(uls ulToas;a (u;x6%xu b6lm
(auL(Xa(Lu m XLaklu;ComD)ulToas9l;sb ;x(u mulToas%l;sb o(uls )
) ulToas;X sa  XaF mm;saX sc%®1saAcG®1aXuan Xomslu;( lx m;X 
;bl(( sa;bl(( sab X( osl;)uu;x(u ;xo;s ;bl(( nlsblm9+L;
 auuanlmUauu slam aX oXsb X;saXU mfaXmuL;l;)
 ) ( lx m;m sb  aX;bl(x msam uu;x(u ;bk   mauu s  aX
(sl msnlsblm9+L;a  lmUauu s )
0fo0hop
FSO ABSSBCT
) x(u ;xL ;saX ssb ;ls  aXo(sa9+L;)x(u ;X sa ;bl(( ak XmlUbs
lm;o  ll msXLl sat  (;x(u ; XaF m)
) m ulToas Xax b;x(u nluu ;bl(( msb o(uls ;x(u ;m ; ms
am b X( osl;k Xl l ;sb Lbk X  lk sb  lX;sulToas)Ulm6uu;x(u ;
xo;s ;bl(( nlsb9+L;)
) amas;bl(;x(u ;mo(uls ;lmsb ;x aw)k sb o(uls ;m;bl(sb x
 s Xb X( osl;b;k Xl l sb Lbk X  lk sb  lX;sulToas)
) u sb (sl ms uan;b  s;lm; (Xs (u;slUmsb m(u lmsb ;bl((lmUaw)
 ) u ; amssb X( osl; lsb XL(bam aXL xlu  aX ;bl((lmU;x(u ;)
bl;l;sa;;oX sbs;bl(x ms;m X  lk amsbsL)bl;l; ;( luuL
lx(aXsmsl ;bl((lmUamboX;L aXXlL ulk XL)

0fo00oJ
K l3BGRBCT BONCBRBNCG
(X c wl;slmUx luamlslaml;am sbsl;(X ; msssb ;sXsa sb sXlu)obamlslam;nluu
 X aX amsb sXluh;((Xa(Xls x lubl;saXL)(X c wl;slmUx luamlslamnluu 
X aX ;maXamuLl sb  X To mL6; k XlsL6aXbXs Xa sb amlslamnaX; m;
oXlmUsb sXlu)b mX aXlmU;ob k ms;amsb ((Xa(Xls ;  (aXsaXx6lsl;lx(aXsms
saamk Lsb am (ssbssb (X c wl;slmUamlslamb;bmU LlmuolmU((ulu 
 ;Xl(saX;)
0fo00oV
K TCCrtNKRBNCtBKRA   RGvNCT CBROCNFOB G
X UmmL6aXslam6lXsb   s;6mamU mlsumaxul ;X  k ms;a ;( lulms X ;s6;
 ;Xl  uanlm; slam9%)99)G)
0fo00oP
KNRNNOl  BC D CRGN S BO
CR K GR
b  auuanlmUX  k ms;a ;( lulms X ;s6mnluu X (aXs  w( lslao;uL3

K TCCrtNKRBNCtBKRA   RGvNCT CBROCNFOB G

 ;oi s ax ;(X Ummsnblu  mXauu lmsb sXlu6b X( osl;nluu masl l 
 w( lslao;uL6X UXu ;;a nb sb XaXmaslsx  s;sb Xls Xl aX w( ls X (aXslmU)aXslam;
C;(amsm ao;6l msu6aXsb X( oslDnluuu;a X (aXs sab X( osl;)

amU mlsumaxul ;flXsb   s;O.rGx  sXls Xl6mnluusb X  aX   w( lslao;uL
X (aXs ;m6o;lmUsb (X klao;uL ;Xl (Xa ;; aXX (aXslmU)

KBOKUTD KNG 
Lx(saxslmmamc;Lx(saxslak Xa; nluu X (aXs lmsb )mLl msuaX
lms mslamuak Xa; nlsbsb sXlusX sx mssbsl;;Lx(saxsl6 k ml mas ou luulmU; Xlao;m ;;
Xls Xlam6nluu X (aXs sab X( osl;lxx ls uLCnlsblm%+baoX;Do;lmUsb 
aXX ;(amlmU(U 6m auuanlmUsb ;x (Xa ;; ;Xl  aX;C;   slam9+D)
 
sXluXoUak Xa; aoX;6;oi s;nluu;sa(sXluXoUa;lmUm ulmluuLxamlsaX ;
((Xa(Xls 6xmUlmU;Lx(sax;f;l     s;sbsxLaoX)



0p


mlm ( m msnluu lmbXU a X kl nlmU;  sLs)
maX Xsa m;oX ;  sLmulxls
sawllsL aX mXauu ;oi s;6sb nluux  ssu ;sam C(XlaXsa;oi s mXauux ms
CaXUmlFslamux  slmUDD6 s Xsna;oi s;bk   mlm o; nlsbsXluXoUm lmu;  sL
X kl nx  slmU s Xsb  l sb;oi sax(u s sb ;soL)b  auuanlmUk X;  k ms;nluu 
 auuan Lsb 3m osXa( ml6sbXaxaLsa( ml6lm  slam6m u kslam;lmulk X mFLx ;)
b ;  k ms;nluu X kl n Lsb nb msnaC%D;oi s; mXauu bk ax(u s 
sX sx msnlsbm;s Xal;aX k XL;lwCxamsb;D6nblb k XaoX; lX;s6oXlmUsb aoX; a 
sb sXlu)uuasb X; Xlao;mmamc; Xlao;k X;  k ms;nluu aox ms )b nluuuaat
ssb sasu;  sLslm s XxlmlmUnb sb Xlsl;(a;;lu saa; sb m wssbX  C8D;oi s;lm
sbl;sXlu)




0x





0xo0



b (Xa(a; ulmlusXlul; lmU;oxlss sasb ;
mk ;slUsaXc
mlsls Xlusa 
( X aXx sam ulmlu;ls Cabm	a(tlm;Dm;m
mk ;slUsaXc
mlsls 
xlmslm LX)
lb u kLa abm	a(tlm;mlk X;lsLbaaua  llm )

b (am;aXCX) kLDnluu sXm;  XXlmUsb X UousaXLaulUslam aXxamlsaXlmUsbl;sXlum
sxmU x mssab X( osl;6
m)ls xamlsaXlmU;buu amos sa m;oX sb boxm
;oi s(Xas slam6sXlu(Xa oX ;6uaXsaXL6sXlulms Xk mslamxlml;sXslam6ms
auu slam(Xa ;; ;X a blUbToulsLmx  ssb b X( osl;;6f
	m6nb m
((Xa(Xls 6X UousaXLUol ulm ;)b ls amlsaXlmUum;buu  lm ;( s;a sb xamlsaXlmU
(Xa ;;)

b X( osl;nluukl;lsabm;	a(tlm;nlsblmExamsb;(XlaXsalmlslslmUsb (Xasaausalm;( s
sb XoU;saXU X 6m ouuLlm aXxsb 
mk ;slUsaXa bl;fb XX ;(am;llulsl ; aX;sol ;m
sb (Xa oX ; aX;;oXlmU Tos maXX saox msslam)sXlulmlslslam;ls kl;lsaX
s u am  X m nluu ( X aXx saX kl nlmk ;slUsaXX ;(am;llulsl ;6sb (Xasaau6mls;
X TolX x ms;nlsbsb 
mk ;slUsaXC;D)oXlmUsb lmlslslam6sb ; X (aXs aXx;C;Dm
asb X( Xslm mssXluxs Xlu;nluu X kl n nlsbsb lmk ;slUsaXh;X ; Xb;s  )oXlmUsb 
aoX; a sb sXlu6b X( osl;nluuxt kl;ls;sasb ;ls ;;m  ;;XLlmaX XsaX kl n
(Xasaauax(ulm 6 wxlm ;6mlmlklou;oi sx luX aX;6m m;oX sbssb 
sXlul; lmUamos aXlmUsasb (Xasaaum( Xslm msX UousaXLX TolX x ms;) u s 
 msXl ;nluu k Xl l nlsb;aoX aox msslam)b X kl na x luX aX;nluu am 
lmxmm Xsa;;oX sbs;oi sam l mslulsLl;xlmslm )





0J	
t

t


bl;sXlunluu amos aXlmUsasb ;smX;a aaulmluXsl aosulm lmsb 
	
EXl(Xsls ol ulm mlsu %9(Xs89%6((ulu Uak Xmx msX Uouslam;6lm;slsoslamu
X ; Xb(aull ;m(Xa oX ;mmLasb Xuau((ulu X UousaXLX TolX x msC;D)
0Jo0

b sXlu(Xasaau6
6
6kluu ;  sLlm aXxslam6;oi saox ms;6;oi sX Xolsx ms
(Xa oX ;C )U)6k Xsl; x ms;D6lm aXxslamaos(Lx ms;Cl) )6
(Lx ms;Dm
ax( m;slamkluu sasb ;oi s;maox msslam kl mlmUsb 
h;Toul lslam;xo;s
 ;oxlss sasb 
 aX sbluX kl nm((Xaku(XlaXsasb sXlu;sXs)

b (am;aXCX) kLDmfaX ;lUm  nluu auuanuum  ;;XLX Uouslam;sa m;oX lmlslum
amUalmU6
sXluX kl n)b (am;aXCX) kLD6;((Xa(Xls xo;s;oxlsm6nb X 
m  ;;XL6aslm((Xaku Xaxsb 
 aXuu;o; To ms(Xasaaux mx ms;mbmU ;sa
sb lm aXx am; msaox ms)


 ((ulu 6sb 
nluumasl Lsb 
.BRABCbhrGa sb  ma sb sXlu6aXl sb sXlu
s Xxlms ; XuL6sb 
xo;smasl Lsb 
.BRABC0xrGa sb s Xxlmslam)X ;am aXsb 
 XuLs Xxlmslamxo;s (Xakl C;  lm lmlX slk %®®9f%®fD)b (am;aXnluu lsb X
(X (X aXX kl nuu;oxl;;lamaox ms;(XlaXsa;oxl;;lamsasb 
)

  sLo(s ; aXoulsowlxnluu (X (X Lsb (am;aXaXls;X (X ; msslk C
b X( osl;6
m)D;X TolX 6 aX;oxl;;lamsasb X u kms
)
0Jof
;X TolX LuauX Uouslam;6sb (am;aXCX) kLDnluu m;oX uuu Uu;( s;X ak X 6
m((Xakua sb ((Xa(Xls X UousaXLal ;aslm 6(XlaXsasXlulmlslslam)
 X TolX 6sb 
(am;aXnluuu;a m;oX sbssb lx(u x msslama ;o;smslux mx mssasb (Xasaaum
asb XX u kmssXluaox ms;b(( mamuL s X((XakuLsb X u kmsX UousaXLosbaXlsl ;)

  sLo(s ; aXoulsowlxnluu (X (X Lsb (am;aXaXls;X (X ; msslk C
b X( osl;6
m)D;X TolX 6 aX;oxl;;lamsasb X u kmsX UousaXLosbaXlsL)
0Jop



 slu;a lm;oXm mfaXlm xmlsLnluu amslm nlsblmsb nXlss mUX  x ms sn  m
abm;	a(tlm;mb X( osl;)
0Jox


m aXx am; msl;(Xa ;;Lnblb;oi skauomsXluLam lXx;bl;aXb XnluulmUm ;;sa
(Xsll(s lm(XslouXsXlu6 s XbklmU  mlm aXx a uu;( s;a sb sXlusbsX 
X u kmssasb ;oi sQ; l;lamsa(Xsll(s )
m aXx am; msl;aox ms Lx m;a 
nXlss m6;lUm ms lm aXx am; ms aXx)

b 
nluu ;oxlss  aX((Xakusasb 
sbsl;X ;(am;lu  aXX kl nm((Xakua sb 
sXlu)bam; ms aXxnluulmuo uua sb X u kms u x ms;oXX msuLX TolX Lsb 
X ;(am;lu X UousaXLosbaXlsL6;n uu;uauaomsLosbaXlsLaX;ss X Uouslam;mmslamu
X TolX x ms;)

  aX X Xolsx msm mXauux mslmsasb sXlu6 b(Xa;( slk mls nluu Ulk m ouu
 w(umslama sb sXlu)m sb  ;; mslulm aXxslamb;  m(Xakl sasb (Xa;( slk 
mls 6msb lmk ;slUsaXl;;oX sbssb lmlkloumls om X;sm;sb lx(ulslam;a 

(Xsll(slmUlmsbl;sXlu6sb mls nluu ;t saUlk am; mssa(Xsll(s lmsb sXluL
;lUmlmUmlm aXx am; ms aXx)masslamsbsnXlss mlm aXx am; msb;  maslm nluu
 x lmsb ;oi sh;x luX aX)a(La sb lm aXx am; ms aXx6salmuo sb 
;oi sh;;lUmsoX 6nluu (Xakl Lsb lmk ;slUsaXsasb ;oi s)


 mx mx mssasb (Xasaau;o;smsluuLus X;sb sXlu ;lUmaXsb (as msluXl;t;sasb 
;oi s;6sb ;oi sh;am; mssaamslmo (Xsll(slamlmsb sXluxo;s aslm )
0JoJ



0JoJo0 UL RNC B CRBOBRr
am l mslulsLa ;oi sh;( X;amusnluu (Xas s lmaXm nlsbe:L	 usb
m;oXm 
aXslulsLmaomslulsLsa 9SSEC	
D6mmslamus(Xas slamun;)	

X Uouslam;X TolX sbs6lmaX Xsa(Xsll(s lmsb sXlu6;oi sxo;s;lUmmosbaXlFslam
 Xaxsb sXlusbsb aX;b b;  mlm aXx a  auuanlmU3

•
bs(Xas s b usblm aXxslamC	
Dnluu auu s  Xax;oi s;lmsbl;sXlu0
•
banluubk  ;;sasbslm aXxslammnbL0
•
banluuo; aXl;ua; sbslm aXxslam0
•
bsb usblm aXxslamxL  oXsb Xl;ua; Lsb X l(l ms;a sb lm aXxslam6m
sbsl sb lm aXxslaml;l;ua; sb lm aXxslamxLmauamU X (Xas s L   XuaX
;ss (XlkLun;0
•
b lm aXxslamauu s aossb X ; XbsXlunluu t (s; (Xs  Xaxsb ;oi sh;
x luX aX;6ossb ;oi snluu u saaslmsb X ; XbX aX; s Xsb 
amuo;lama sb sXlu0
•
b sb Xsb osbaXlFslamamslm;m w(lXslams 0m
•
b XlUbs;a X ; Xb;oi ssaX kat bl;aXb XosbaXlFslam)

msb  k mssbs;oi sX kat ;osbaXlFslamsaauu saXo; bl;aXb X	
6sb lmk ;slUsaX6L
X Uouslam6X slm;sb lulsLsao; uulm aXxslamauu s (XlaXsasb X kaslama ;oi s
osbaXlFslam)aX;oi s;sbsbk X kat osbaXlFslamsaauu saXo; 	
6ss x(s;nluu 
x saaslm( Xxl;;lamsaauu ssu ;sklsu;sso;Cl) )6sbssb ;oi sl;ulk Dssb  ma 
sb lX;b ou sXlu( Xla)


max(ulm nlsb
	Uol ulm ;m((ulu (Xs;a %9lsl;X TolX x mssbssb 
lmk ;slUsaXmlm;slsoslam( XxlsosbaXlF X (X ; msslk ;a b X( osl;6sb X UousaXL
osbaXlsl ;msb 
lX s ;;saX kl nsb ;oi sh;aXlUlmux luX aX;ssb ;ls  aX
k Xl lslama sXlucX us (Xa oX ;ms)

 ;oX ;sa(Xas sam l mslulsLlmuo 3amuLomlTo sXlumox Xmlmlslu;nluul msl L
;oi s;amsb aXasb Xaox ms;;oxlss sasb (am;aX)bl;lm aXxslam6saU sb Xnlsb
sb ;oi sh;s a lXsb6nluu o; lmsb s;  aX;oi sl msl lslam)oi smx ;aX
X ;; ;nluumas  ms X lmsb aXs; )axs Xlu XlmU;oi sh;mx nluu 
t (sam lu Lsb (am;aX)oi s;nluu lm aXx a sb lXXlUbs;nlsblmsb 
)
0JoV




 X;amusa sb lmk ;slUsaX;m;oclmk ;slUsaX;xL lmuo lmsb (am;aXs; 6
m;buu sX s lmax(ulm nlsbuu((ulu un;mX Uouslam;)b mXblklmUaX
(Xa ;;lmU( X;amus( XslmlmUsasb lmk ;slUsaXaX;oclmk ;slUsaX6sb (am;aXnluust uu
((Xa(Xls x ;oX ;sa;  UoXm(X k ms ;;sasbl;sLmLomosbaXlF (XsL)

0JoP




b  lmm ; aXsbl;sXlunluu ;oi ssa; (Xs nXlss mUX  x ms sn  msb 
b X( osl;mabm;	a(tlm;mlk X;lsL)uu
mk ;slUsaX lmmlul;ua;oX ;;((ulu sa
%9XsW+nluu ((Xa(Xls uL(Xakl mX kl n Lsb abm;	a(tlm;
)



0V

	

0Vo0	
x mx ms;sasb (Xasaau;buu (umm 6aox ms m;lUmsoX osbaXlF (XlaXsa
lx(u x msslam)


 mx mx mssasb (Xasaaul;X TolX 6sb x mx msnluu aXlUlms maox ms L
sb (am;aX)b nXlss mx mx msxo;s ;oxlss sasb abm;	a(tlm;
 aXsb aXh;
((Xaku)

x mx ms;;( l luuLlmkauklmUbmU sasXlu ;lUm6Xl;tsa;oi s6lmX ; saa;lmUaX
 w(a;oX 6;oi smox XlmX ; 6lslamaXX xakua m ns ;s;aX(Xa oX ;6nluu 
X kl n m((Xak Lsb 
ssb 
mk ;slUsaXh; lulsL)

b x mx msnluu ;oxlss  aXxuuLsasb aXasb XX UousaXLosbaXlsl ;Lsb 
(am;aX;((ulu 6m;( l luuLnb mmlmX ; saa;lmUaX;oi s w(a;oX mfaX
;oi smox Xb;  m(Xa(a; 0aX6nb msb lslamaXX xakua m
mk ;slUsaXl;
m  ;;lss )


s x;X TolXlmU(Xasaaux mx msnlsb
mmfaXmax( s msosbaXlsL
((Xakulmuo 6osX masulxls sa6sb  auuanlmU3

•
bmU sasXlu ;lUm
•
l;tsa;oi s
•

mX ; saa; aX;oi s w(a;oX saXoU
•
oi smox XlmX ; a xaX sbm%®J
•
lslamaXX xakua s ;s;mfaX(Xa oX ;
•
lslamfX xakua m n
mk ;slUsaX


s;baou  oXsb Xmas sbs6l mx mx mssasb (Xasaau;o;smsluuLus X;sb sXlu ;lUm
aXsb (as msluXl;t;sasb ;oi s;6sb lXam; mssaamslmo (Xsll(slamlmsb sXlunluu 
aslm )

0Vof






  aX sb sXluxL Ulm6 Xslmaox msslamX TolX LX Uouslam;nluu (Xakl L
sb 
mk ;slUsaX)b X TolX aox msslamnluu t (sLsb (am;aX)

aox ms;sxlmlxoxX TolX sa Ulmsb sXlulmuo 6osX masulxls sa6sb  auuanlmU3

•
;lUmsoX cosbaXlF (XasaaumamsXs0
•
a(La sb a  llu
((Xakua sb sXlumsb 
x x X;ul;s0
•
oXX msoXXlouls aXsb (Xlml(ulmk ;slUsaXmmL;;als lmk ;slUsaXC;Dnba
nluu lmkauk lmsb sXlu0
•

mlslama ((Xa(Xls X lsslam aXmLuaXsaXl ;sa o; lmsb sXlum
a(La sb maXxuXmU ; aXs ;s;sa ( X aXx LsbsuaXsaXL0
•
XlUlmuaXx9WG%Css x msa 
mk ;slUsaXD6((Xa(Xls uLax(u s m;lUm 0
•
a(La sb 
c((Xak am; ms aXxamslmlmU( Xxl;;lam aXolsLsb abm;
	a(tlm;
mfaXsb 0
•
lmmlul;ua;oX  aXx; aXuulmk ;slUsaX;ul;s amaXx9WG%0
•
 Xsl ls  aXsXlusXlmlmU0
•
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•
 Xl lslama Xlml(u
mk ;slUsaX (slulsL XaxuaumfaXmslamu Xx ms
ul;sC;D)

b (am;aXnluu m;oX sbsuuaox msslamsbsl;X TolX sa lm(u   aX sb sXluxL
;sXs6lmaXm nlsb
	Em(am;aX;6nluu kluu   aX mLsXlu;ls ;X 
lmlsls )
0Vop


b 
nluuxlmslmul;sa ((Xa(Xls uLToul l ( X;am;sanbaxb f;b b; u Us sXlu
osl ;mnluu m;oX sbsuu( X;am;;;l;slmUlmsb amosa sb sXluX lm aXx a sb lX
aulUslam;)uu( X;am;osbaXlF saxt  msXl ;mfaXaXX slam;amsb ;nluu lmuo 
amsbl;aox ms)uu msXl ;lmsb ;oi sh;nluu ;o((aXs L;aoX aox msslamnb X 
((Xa(Xls )

aoX aox ms;X sb aXlUlmuaox ms;6s6X aX;m Xsl l a(l ;a aXlUlmuX aX;
a ulmlu lmlmU;6a; Xkslam;mslklsl ; Xaxnblbsb ;oi sh;sX aslm )
b ; mlmuo 6osX masulxls sa6ba;(lsuX aX;6ulmluma  l bXs;6uaXsaXL6
x lacs bmlu (Xsx msm(bXxLX aX;6lXl ;6xlXa lb ;6sX ;6a(l ;aX
sXm;Xl(slam; Xsl l  s Xk Xl lslam; lmUoXs max(u s 6(basaUX(blm Uslk ;6
xlXa luxaXxUm slx l6cXL;6maXX ;(am m )

b 
msXlu;s  X X ;(am;lu  aXxlmslmlmUax(X b m;lk m msXulF  lulmU;L;s x
Cls Xlulu faX
Da uusXlucX us C ;; msluDaox msslam6;olsu  aXlm;( slams
mLslx LX (X ; msslk ;a ((ulu X UousaXLosbaXlsl ;)b 
fxo;sam;l;sa sba; 
aox ms;sbslmlklouuLaXauu slk uL( Xxls kuoslama sb amosa sb sXlumsb 
ToulsLa sb s(Xao )b 
fnluuamslm;xlmlxoxuuX u kmsaox ms;m
aXX ;(am m ;aosulm lm
	 slam98m%9Xs89%)WG6lmuolmUt L
aox ms;;ob;sb 
mmLx mx ms;6(XasaaummLx mx ms;6;lUm 
;6a(l ;
a ax(u s ;6
((Xakuaox ms;6lmmlul;ua;oX  aXx;6;oi sl msl lslamul;s;6
 mXauux msuaU;6 u Uslama osbaXlsLuaU6;s  Toul lslamaox ms;6uaXsaXLmaXxu
XmU ;6X aX;X uslmUsasb sXluXoUlmuolmUaomslulsLX aX;)XoUaomslulsL
X aX;nluu6sxlmlxox6amslmlm aXxslamX UXlmUX  l(s6;bl(x ms6ml;(a;lslam)b
 aXxa XoUaomslulsLX aX6sxlmlxox6nluuamslm
mx 6s XoU
;bl(( fX  lk 6s 6TomslsLmsbfa 6aXuasmox X aXl mslsLa  b;bl(x ms)
m
lslam6uuaXlUlmu;aoX aox ms;;o((aXslmU msXl ;lmsb nluu xlmslm m 
X luLkluu )

b (am;aXflmk ;slUsaXCX) kLDnluuxlmslm Tos lmk ;slUslamu(XaosX aX;m
 lmmlulms X ;sX aX;;( X%9XsW+)EmXs89%)WG aXmau ;;sbm%L X; s Xsb 
u;sxXt slmU((ulslamb;  m((Xak L0aX6lmsb  k mssbssb xXt slmU
((ulslamb;mas  m((Xak L6 aXmau ;;sbm%L X; s Xsb u;s;bl(x msf
 ulk XLa sb XoU aXlmk ;slUslamuo; l;l;amslmo mb;  mmasl l a sb 
l;amslmoslam)

b 
;buuxlmslm Tos aox msslamfX aX;a 
slklsl ;;( X%9
XsWE)99W aXsu ;s8L X; s Xax(u slama sb X ; Xb)

a mu  kuoslam;mfaXols; XaxX UousaXLosbaXlsl ;6sb lmk ;slUsaXlslamuuLnluu
t  (X aX;6lmuolmUsb l mslsLa uu(Xsll(slmU;oi s;C;o  ll mslm aXxslamsaulmt
X aX; )U)6x luX aX;D6uuaXlUlmu6;lUm lm aXx am; ms aXx;6ma(l ;a uu;66
;aoX aox ms;6 slu X aX;a sX sx msl;(a;lslam6mX us  ;; msluX UousaXL
aox ms;)b aox ms;ul;s ak nluu X slm Lsb lmk ;slUsaX aX;uamU;m   
saax(uLnlsbmslamumlms XmslamuX Uouslam;CU m XuuL%L X; s Xl;amslmolmUulmlu

 k ua(x msaX s Xsb u;sxXt slmU((XakuD)b X( osl;aXls;X (X ; msslk nluu
masl LX) kLCaXabm;	a(tlm;mlk X;lsLDnb msb sXlucX us X aX;X mauamU XX TolX )

0Vox

b sXlul;sb (XlxXLsauu slamlm;sXox ms aXsb sXlu); X (aXs aXxCDnluu 
oslulF  aXsb auu slama uusmuusnluu  ms X o;lmUsb mUul;bumUoU m
;baou t (soXX mssa mu sb xamlsaXsaX kl nsb ;oi s;h;sso;sbXaoUbaossb aoX; a 
sb sXlu)


maX Xsaxlmslmam l mslulsL6amuLsXlumox X6;oi smox X6lmlslu;ms a lXsb
xL o; sal msl Lsb ;oi slmsb )
 sb ;oi sh;mx (( X;ammLasb X
aox msC )U)uaXsaXLX (aXsD6lsnluu auls Xs amsb a(La sb aox mssa ;o((ul 
sasb lmk ;slUsaX;ls mX (u lm;s nlsbsb ;oi smox Xm;oi sh;lmlslu;)b 
lmk ;slUsaXnluuxlmslm( X;amu;oi sl msl lslamul;sC;oi smox X;nlsb
aXX ;(amlmU;oi sl msl l X;Dsa mu X aX;sa l msl l mk Xl l ;osb msl)
oi ssflm aXxslamnluu t (sam l mslu6mnluu xmU aXlmUsa((ulu 
uau6;ss 6m   XuX Uouslam;)
0VoJ


t

t


b lmk ;slUsaXnluu( XxlssXlucX us xamlsaXlmU6ToulsLols;6mlm;( slam;L
b X( osl;mUak Xmx msX UousaXLosbaXlsl ;a uusXlucX us aox ms;C )U)6;aoX 
aox ms;6X UousaXLaox ms;6sauu slamlm;sXox ms;6; X (aXs aXx;D)b 
lmk ;slUsaXnluu m;oX sb (lulsL aXlm;( slam;a ((ulu sXlucX us  lulsl ;)b 
lmk ;slUsaXnluu m;oX sbssb sXluxamlsaXaXmLasb Xax(ulm aXX kl n Xl;Ulk m
 ;;sauusXlucX us aox ms;msXlucX us  lulsl ;)

Xsll(slam;mlmk ;slUsaXlmsbl;sXlulx(ul ;sb  (sm a (as mslulm;( slamL
Uak Xmx msX UousaXLosbaXlsl ;6sb ;(am;aXaXls;X (X ; msslk C;D)

ssb (am;aXh;l;X slamaoX aox ms Xl lslamCDxL ( X aXx amuusls x;
aX( X msU sb X a )
0VoV



mlslamsasb ulmluamlsaXlmUax(am msa sbl;(Xasaau6sb b X( osl;h;oulsL
;;oXm CD (Xsx ms;buu ;sul;bmolslmUumaox ms; (Xs  Xaxsb (Xasaau
sa ;sul;bsb Xls XlLnblblm ( m msolslmU;buu amos oXlmUsb amosa sb 
sXlusa;; ;;ax(ulm nlsbm((ulu X UousaXLX TolX x ms;)saX
aox msslamols ;buu ;; ;;  aXax(ulm sasb (Xasaau6oXLlmX uslamsa
;aoX aox ms;max(ulm sa((ulu X Uouslam;)
0VoP




uulm aXxslam(Xakl X UXlmUsb sXlu6;n uu;uulm aXxslamauu s faox ms 
oXlmUsb aoX; a sb sXlu6nluu X UX ;am l mslu)

ulmlusXluX (aXsnluu (X (X o(amax(u slama sb sXlu)b (am;aXnluul;ua; sb 
sXluX ;ous;6lmsb  aXxa ulmlusXluX (aXs;Lma(;l;6sasb 
msb ((ulu X UousaXL
osbaXlsl ;nlsblmam L Xa sb  ma sb sXlu)b  aXxsa sbl;;Lma(;l;msbsa sb 
ulmlusXluX (aXsmls; moxnluuax(uLnlsb
	8Uol ulm ; aX;sXosoX mams ms
a ulmlusXluX (aXs)


b  lmmlul;ua;oX lm aXxslamnluu (Xakl sab X( osl;msb abm;	a(tlm;

(XlaXsasXlu(Xsll(slam Xaxuu
;moc
mk ;slUsaX;nbaX lmkauk lmsb sXlum
mx amsb 9WG% aXx

LamoslmUsbl;sXlu6sb 
mk ;slUsaX  lXx;sab X( osl;sbsb aX;b nluuxlmslm6lm
;sXlsam l m 6lm aXxslam oXml;b Lb X( osl;lmuolmUsU m Xs  Xaxsbl;sXlu
m(X ulxlmXLuaXsaXLX ;ous;6 w (s; w x(s  aXX UousaXL(oX(a; ;)


uusU m Xs oXlmUsb amosa sbl;sXlul;anm Lsb (am;aXCX) kLDmxL 
;bX nlsbb X( osl;;aosulm lm; (Xs amsXs sn  mb X( osl;mabm;
	a(tlm;)

uuxmo;Xl(s;6;sXs;6aXasb X(X ; msslamxs Xlu;m U m Xs ssb l;X slama sb 
(am;aXCX) kLD)

0P
us X6oL6	  Xs su)6 s Xxlmms;a 	oxm uulUXslamXa;;Xlmmasb ulu
 uu;6
	eenit %®®89G®CSD3++SGc+W®W

Xlstl6luls uua6u(ams 6(mla;6u a6amkl)b mslc%®x
oulsowlxlms XXo(s;sb L;X Uous ct((fmluf
fX ;l;sm uaa(lmc	
 uu;3Xau lm; m;lslFslamsa
(a(sa;l;)
msmau)%®9908ICED39EI8cS+

 l6 su)6
x(sa XlsowlxamX u(; Xs ml;lulsLlmm oXaxL ulsl;a(sl
n Ih  rt((
tnri 9GC9®D9%%Wr9%8®

lFFaa6auul6 (l 6 su)X ku m a m oXaxL ulsl;a(sl;( sXoxl;aX Xm
(b masL( l;sXloslam)
nrt %®®S0%WE39IS9r9ISI

u  t X6omt6to; su)6;slxslama a; X TolX x ms; aX;o;sslm iaat
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aat6lmittten Ih ( rt((c )aat%®®E6+sb m)6LuaX-Xml;3 naXt

X  6x6aXUm6b m6oms6 mlm)6m( m usoLa sb    s;a 
lsowlxlm oXaxL ulsl;(sl)nrt t %®®W0E+39%G®r9%G%

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lx(Xak  mUU x msa Uxx

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ao;  maUX sa u;)x Xlmal sLa ulmlumauaUL%®99a;s XX ; msslam

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UlmlmUsans Xbmm u
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 mlmU

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nrt%®99cfsRgfCL

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m uxxslamlmousl(u u Xa;l;6tti%®®I38CGD3 %WWS

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