The Impact of Donor and Recipient Sex on Long-term Outcomes Following Living Donor Kidney Transplantation
Conditions: Kidney Transplant Failure and Rejection, Gender
Sponsor: Erasmus Medical Center

Sex impact on living donor kidney transplantation  
 
NON WMO Research protocol                                                                                                 1.0, 01-07-2024                             
1 
 
 
 
 
 
 
 
 
 
 
 
RESEARCH PROTOCOL 
for non-WMO-applicable research 
 
Official Title: The Impact of Donor and Recipient Sex on 
Long-term Outcomes Following Living Donor Kidney 
Transplantation 
 
Brief Title: Sex Impact on Long-term Outcomes of LDKT 
 
NCT number: NCT06016283 
 
 
01-07-2024, versie 1.0 
 
 
 

Sex impact on living donor kidney transplantation  
 
NON WMO Research protocol                                                                                                 1.0, 01-07-2024                             
2 
 
Full title of protocol  
The Impact of Donor and Recipient Sex on Long-term Outcomes 
Following Living Donor Kidney Transplantation 
Short title or Acronym 
Sex impact on living donor kidney transplantation 
Protocol ID/ Panama number 
 12601 
Version 
1.0 
Date 
01-07-2024 
Study coordinator  
 
 
Project team members 
Y. Fang, MD 
Erasmus MC, University Medical Center Rotterdam 
Department of Surgery 
P.O Box 2040, 3000 CA Rotterdam, The 
Netherlands 
y.fang.1@erasmusmc.nl 
 
Dr R.W.F. de Bruin, PhD 
Erasmus MC, University Medical Center Rotterdam 
Department of Surgery 
P.O Box 2040, 3000 CA Rotterdam, The 
Netherlands 
r.w.f.debruin@erasmusmc.nl 
Principal investigator2 
(in Dutch: hoofdonderzoeker/ 
uitvoerder) 
 
 
 
<Multicenter research3: 
principal investigator per site> 
Dr. R.C. Minnee, MD, PhD 
Erasmus MC, University Medical Center Rotterdam 
Department of Surgery 
P.O Box 2040, 3000 CA Rotterdam, The 
Netherlands 
r.minnee@erasmusmc.nl 
 
Dr. R.A. Pol, MD, PhD 
University Medical Center Groningen 
Department of Surgery 
P.O Box 30.001, 9700 RB Groningen, The 
Netherlands 
r.pol@umcg.nl 
Sponsor4 (in Dutch: 
verrichter/opdrachtgever) 
Erasmus University Medical Center Rotterdam 
P.O Box 2040, 3000 CA Rotterdam, The 
Netherlands 
Subsidizing party5 
N/A 
 
 
 

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Within one year after the end of the study a final study report will be submitted with the results of the 
study, including any publications/abstracts of the study. 
 
 Publication 
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 References 
1. 
Gratwohl A, Dohler B, Stern M, Opelz G. H-Y as a minor histocompatibility antigen in kidney 
transplantation: a retrospective cohort study. Lancet. 2008;372(9632):49-53. 
2. 
Kim SJ, Gill JS. H-Y incompatibility predicts short-term outcomes for kidney transplant recipients. 
J Am Soc Nephrol. 2009;20(9):2025-33. 
3. 
Zeier M, Dohler B, Opelz G, Ritz E. The effect of donor gender on graft survival. J Am Soc 
Nephrol. 2002;13(10):2570-6. 
4. 
Aufhauser DD, Jr., Wang Z, Murken DR, Bhatti TR, Wang Y, Ge G, et al. Improved renal 
ischemia tolerance in females influences kidney transplantation outcomes. J Clin Invest. 
2016;126(5):1968-77. 
5. 
Vinson AJ, Zhang X, Dahhou M, Susal C, Dohler B, Melk A, et al. A multinational cohort study 
uncovered sex differences in excess mortality after kidney transplant. Kidney Int. 
2023;103(6):1131-43. 
6. 
Kayler LK, Rasmussen CS, Dykstra DM, Ojo AO, Port FK, Wolfe RA, et al. Gender imbalance 
and outcomes in living donor renal transplantation in the United States. Am J Transplant. 
2003;3(4):452-8. 
 
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