The Effect of Mild Exercise While Receiving Chemotherapy on the Psychology of the Cancer Patient
Phase: NA
Conditions: Cancer, Exercise, Stress
Sponsor: Christine Mavrogiannopoulou

STUDY PROTOCOL 
Title: The Effect of Mild Exercise While Receiving Chemotherapy on the Psychology of 
the Cancer Patient 
NCT Number: NCT06943638 
Date: 31 July 2025 
 
1. Background and Rationale 
Cancer patients undergoing chemotherapy often experience heightened levels of 
anxiety. Non-pharmacological interventions such as mild physical activity may 
alleviate these symptoms. This study investigates whether a short, tailored exercise 
program can reduce anxiety levels in adult cancer patients. 
 
2. Objectives 
 
Primary Objective: 
To assess the effect of a mild, individualized exercise program on state anxiety 
levels in cancer patients undergoing chemotherapy. 
 
3. Study Design 
This is a prospective observational cohort study conducted at the General Oncology 
Hospital of Kifissia "Agioi Anargyroi" in Athens, Greece. 
 
4. Study Population 
 
Inclusion Criteria: 
o Age ≥ 18 years 
o Receiving chemotherapy 
o Ability to understand and provide informed consent 
 
Exclusion Criteria: 
o Refusal to participate 
o Cognitive or sensory impairment affecting ability to engage 
o Inability to mobilize independently 
 

5. Intervention 
Participants receive 20-minute sessions of mild physical exercises designed by a 
licensed physiotherapist, including warm-up, upper limb, lower limb, and stretching 
routines. Sessions are tailored to each participant’s physical condition and conducted 
in person. 
 
6. Outcome Measures 
 
Primary Outcome: 
Change in state anxiety level as measured by the Spielberger State-Trait 
Anxiety Inventory (STAI-Y1) before and after the intervention. 
 
7. Data Collection 
The STAI-Y1 will be administered pre- and post-intervention. Demographic data 
including age and gender will be collected at baseline. 
 
8. Ethical Considerations 
Ethics approval was granted by the Ethics Committee of the General Oncology 
Hospital of Kifissia (Protocol #779/15-1-2024). Written informed consent will be 
obtained from all participants. 
 
9. Data Management and Confidentiality 
Data will be anonymized and stored securely. Only study investigators will have 
access to identifiable information. All analyses will use coded identifiers. 
 
10. Study Timeline 
 
Start Date: 02 December 2024 
 
End Date:  24 March 2025