Evaluation of the Efficacy of Different Drugs in the Treatment of the Pain in Patients With Temporomandibular Disorder
Phase: PHASE4
Conditions: Temporomandibular Disorder
Sponsor: Yuzuncu Yil University

02.09.2022 
 
Evaluation of the Efficacy of Different Drugs in the Treatment of Pain in Patients with 
Temporomandibular Disorder 
 
Levent Ciğerim DDS, PhD 1, Mehmet Güzel1, Zeynep Dilan Orhan1 
1 Van Yuzuncu Yil University, Faculty of Dentistry, Department of Oral and Maxillofacial 
Surgery, Van, TURKEY 
Corresponding author: Levent Ciğerim 
Address: Van Yüzüncü Yıl University, Faculty of Dentistry, Department of Oral and Maxillofacial 
Surgery, Van, Turkey Postal Code: 65080 
E-mail address: levent139@hotmail.com Phone:+905321633287 Office Phone: 904322251744  
Fax: +904322251747 
Levent CİĞERİM 
Van Yuzuncu Yil University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery 
levent139@hotmailmail.com, +905321633287, https://orcid.org/0000-0001-5218-8568 
Mehmet GÜZEL 
Van Yuzuncu Yil University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery 
dtmehmetguzel@gmail.com, +905363609854, https://orcid.org/0000-0002-9621-0496 
Zeynep Dilan Orhan 
Van Yuzuncu Yil University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery 
zeynepdilanorhan@gmail.com, +905425525525, https://orcid.org/0000-0003-1333-9073 
 
 
 
 
 
 
 

Study Protocol, Methods and Procedures to be Applied: 
 The study is planned to be carried out on 200 patients aged 18 and over, who applied 
to Van Yüzüncü Yıl University, Faculty of Dentistry, Department of Oral and Maxillofacial 
Surgery, with complaints of pain due to tempromandibular disease. When patients first apply 
to the clinic, their anamnesis will be taken and they will be directed to mr imaging after 
clinical evaluation. Patients who meet the inclusion criteria and volunteer will be included in 
the study. Patients will be randomly divided into 4 groups. Medications will be given to 
patients by auxiliary staff and the study will be double-blind. 
Medicines will be given as follows. Dexketoprofen Trometamol + Thiocolchicoside 
(25mg + 4mg, 2x1) in the 1st group, Dexketoprofen Trometamol + Paracetamol (25mg + 
300mg, 2x1) in the 2nd group, only Dexketoprofen Trometamol (25mg, 2x1) in the 3rd group 
and paracetamol 500 in the 4th control group. mg (4x1) will be given. In addition, patients in 
each group will use the occlusal plate with study drugs for a maximum of 8 hours per day (at 
night). Medicines will be used regularly for 2 weeks. Paracetamol 500 mg will be used with 
the occlusal plate for the next 2 weeks, only if needed. The pain values of the patients will be 
evaluated with the VAS scale, and the amount of mouth opening will be evaluated by 
measuring the distance between the incisal edges of the lower and upper central teeth. Follow-
up and controls of the patients will be done in the preoperative period, at the 2nd and 4th 
weeks postoperatively, and the findings will be recorded. After the 1st month, the patients will 
be followed up to the 3rd month and the treatment of those who need additional treatment will 
be continued. 
Obtained data will be analyzed and evaluated statistically. 
 
Statistical Data Analysis: 
Descriptive statistics for continuous variables in our study; As Average, Standard 
Deviation, Minimum and Maximum values; will be expressed as numbers and percentages for 
categorical variables. Mann-Whitney U analysis will be used to compare group means in 
terms of continuous independent variables. In addition, the Wicoxon test will be calculated in 
the comparison of double dependent groups. In order to determine the relationship between 
these variables, Spearman correlation coefficients will be calculated separately for the groups. 
Chi-square test will be used to determine the relationship between groups and categorical 
variables. Statistical significance level will be taken as 5% in calculations and SPSS statistical 
package program will be used for calculations.