Passive Stretching and Dietary Nitrate Rescue Functional Capacity in Peripheral Arterial Disease
Phase: PHASE2
Conditions: Peripheral Arterial Disease, Walking, Difficulty, Inflammation
Sponsor: University of Wisconsin, La Crosse

 
 
 
 
 
 
 
 
 
NCT number not yet given. 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Protocol Synopsis  
On testing days, patients start with a baseline blood-draw and 15-min supine rest period, then 
blood pressure will be taken from each arm in duplicate and measured throughout testing 
(Finapres medical systems, The Netherlands). We will then use a non-invasive doppler probe to 
assess carotid-femoral arterial stiffness. Next, following reported guidelines, flow-mediated 
vasodilation of the popliteal artery and near-infrared microvascular function tests will be 
performed to assess arterial reactivity and endothelial function of the lower leg. The popliteal 
artery and calf of the most effected leg will be used. Diameters will be analyzed using 
commercially available vascular analyzing software (Quipu cardiovascular suit, Italy). Next, we 
will perform two bouts of calf plantar flexion exercise, separated by 15-min, for calf 
mitochondrial function. Finally, we will perform out primary outcome measurements (six-minute 
walk test) and a final blood draw. We anticipate these testing to take approximately 2-3 hours.