Phase 1/2 Open Label, Dose-escalation Study of the Safety and OcUlar Tolerability of a Single Intravitreal Injection of RBM-007 in Subjects witH ExudatIve Age-related Macular Degeneration (SUSHI)
Phase: PHASE1
Conditions: Age-related Macular Degeneration
Sponsor: Ribomic USA Inc

 
 
CONFIDENTIAL 
 
 
Clinical Study Protocol 
RBM-007-001  
Phase 1/2 
Amendment 1 
 
Phase 1/2 Open label, Dose-escalation Study of the Safety and OcUlar 
Tolerability of a Single Intravitreal Injection of RBM-007 in Subjects witH 
ExudatIve Age-related Macular Degeneration (SUSHI) 
 
 
 
 
 
RIBOMIC USA Inc. 
2120 University Ave. 
Berkeley, CA 94704 
 
 
 
 
Version: 
25 September 2018  
Original: 
2 June 2018 
Amendments included: 
One 
 
 

RIBOMIC 
USA Inc. 
Clinical Study Protocol 
 
Confidential 
 
Study RBM-007-001 Protocol Amendment 1 
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Investigator Agreement 
 
I have read the Protocol and agree to conduct the study as outlined and in accordance with 
21CFR Parts 11,50,54,56, and 312,42 USC282 (j), the Declaration of Helsinki, ICH GCPs, and 
applicable local regulations. I will not initiate the study until I have obtained written approval by 
the appropriate Institutional Review Board (IRB) or Ethics Committee (EC) and have complied 
with all financial and administrative requirements of the governing body of the clinical 
institution and RIBOMIC USA Inc. as the Sponsor. I will obtain written informed consent from 
each study subject prior to performing any study specific procedures. 
I understand that my electronic signature on an electronic case report form indicates that the data 
therein has been reviewed and accepted by me as the Investigator. I agree to maintain the 
confidentiality of all information received or developed in connection with this protocol. 
 
INVESTIGATOR: 
Signature/Date: 
 
 
Name: 
 
 
Address: 
 
 
 
 
 
Phone: 
 
 
 
 
 

RIBOMIC 
USA Inc. 
Clinical Study Protocol 
Contact Information and Protocol Authorization 
Clinical Study Protocol 
RBM-007-001 
Phase 1/2 
Amendment 1 
Confidential 
Phase 1/2 Open label, Dose-escalation Study of the 9afety and OcUlar 
Tolerability of a 9ingle Intravitreal Injection of RBM-007 in Subjects witH 
Exudat!ve Age-related Macular Degeneration (SUSHI) 
Role 
Company/Sponsor Signatory 
Physician/Medical Monitor 
Clinical Study Manager 
Pharmacovigilance Lead 
Back-up Pharmacovigilance Lead 
Study RBM-007-001 Protocol Amendment I 
Contact information 
Yusuf Ali, Ph.D. 
CEO, RIBOMIC USA Inc. 
  r-A-.  s--J .l....a \ 	 
Signature 
Date 
 • 
Robert Bhisitkul, MD 
10 Koret Way, K301 
San Francisco, CA 94143 
(415)794-1215 
Ryan Wilson 
101 Jefferson Drive, Suite 114 
Menlo Park, CA 94025 
(402) 290-7259 
Yusuf Ali, Ph.D. 
2120 University Ave. 
Berkeley, CA 94704 
(707) 287-4313 
Robert Bhisitkul, MD 
IO Koret Way, K30 I 
San Francisco, CA 94143 
( 4 I 5) 794-1215 
Page- 3-
25 September 2018 

RIBOMIC 
USA Inc. 
Clinical Study Protocol 
 
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Study RBM-007-001 Protocol Amendment 1 
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25 September 2018 
 
Abbreviations and Terms 
Abbreviation 
Expression (Name) in full 
AE(s) 
adverse event(s) 
ALP 
alkaline phosphatase 
ALT 
alanine transaminase 
AMD 
age-related macular degeneration 
AST 
aspartate aminotransferase 
BCVA 
best corrected visual acuity 
BUN 
blood urea nitrogen 
CNV 
choroidal neo-vascularization 
CRF 
Case report form 
CST 
central subfield thickness 
dL 
deciliter 
eCRF(s) 
Electronic Case Report Form(s) 
EDC 
EC 
Electronic Data Capture 
Ethics Committee 
EKG 
electrocardiogram (= ECG) 
ESI(s) 
event(s) of special interest 
ETDRS 
Early Treatment of Diabetic Retinopathy Study 
FDA 
Food and Drug Administration 
FGF 
fibroblast growth factor 
GCP 
Good Clinical Practice 
GGT 
gamma-glutamyl transpeptidase 
GMP 
GLP 
Good Manufacturing Practice 
Good Laboratory Practice 
hCG 
human chorionic gonadotropin 
HCT 
hematocrit 
HDL 
high density lipoprotein 
HGB 
hemoglobin 
HIPAA 
Health Insurance Portability and Accountability Act of 1996 
ICF 
informed consent form 
ICH 
International Conference on Harmonization 
IEC 
Independent Ethics Committee 
IND 
Investigational New Drug Application 
IOP 
intraocular pressure 
IRB 
Institutional Review Board 
ITT 
intent-to-treat 
IVT, i.vt. 
intravitreal 
LDH 
lactate dehydrogenase 
LDL 
low density lipoprotein 
LOCF 
Last Observation Carried Forward 
MCH 
mean corpuscular hemoglobin 
MCHC 
mean corpuscular hemoglobin concentration 
MCV 
mean corpuscular volume 
MedDRA 
Medical Dictionary for Regulatory Activities 
mg 
NOAEL 
milligram 
no observed adverse effect level 
µL 
microliter 
mL 
milliliter 
mmHg 
millimeter of mercury 
PLT 
platelet 
RBC 
red blood cell 

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Abbreviation 
Expression (Name) in full 
SAE(s) 
serious adverse event(s) 
SAP 
statistical analysis plan 
SD-OCT 
spectral domain optical coherence tomography 
SGOT 
serum glutamic oxaloacetic transaminase 
SGPT 
SRT 
serum glutamic pyruvic transaminase 
Safety Review Team 
ULN 
upper limit of normal 
VEGF 
vascular endothelial growth factor 
WBC 
white blood cell 
 
 
 
 
 
 
 

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1 SYNOPSIS 
Study Number: 
RBM-007-001 
Name of Sponsor/Company: 
RIBOMIC USA Inc. 
Name of Investigational Product: 
RBM-007 injectable solution 
Name of Active Ingredient: 
RBM-007 
Title of Study 
Phase 1/2 Open label, Dose-escalation Study of the Safety and 
OcUlar Tolerability of a Single Intravitreal Injection of RBM-
007 in Subjects witH ExudatIve Age-related Macular 
Degeneration (SUSHI) 
Study Period: 
Approximately 1 year 
Estimated date first subject enrolled: August 2018 
Estimated date last subject completed: August 2019 
Phase of Development: 
Phase ½ 
Primary Objective: 
 
To assess the safety and tolerability of a single intravitreal 
injection of three dose levels of RBM-007 (0.2 mg/eye, 1.0 
mg/eye and 2.0 mg/eye) in subjects with exudative age-related 
macular degeneration. 
Secondary Objective: 
 
To evaluate the bioactivity of three dose levels of RBM-007 in 
subjects with exudative age-related macular degeneration. 
Methodology: 
This is an open label, non-controlled, dose-escalating study 
assessing the safety, tolerability, and bioactivity of a single 
intravitreal (i.vt.) injection of RBM-007 in approximately 
nine subjects with exudative age-related macular 
degeneration (AMD). 
 
Following a screening evaluation, subjects will receive a 
single intravitreal injection of RBM-007 in the study eye. 
The primary endpoint of the study is at 28 days post-
injection of RBM-007, with safety evaluation through 56 
days. The study will initiate with the lowest dose of 0.2 mg 
in the first cohort of three subjects, proceeding to a second 
cohort of three subjects at a dose of 1.0 mg, then a third 
cohort of three subjects at a dose of 2.0 mg. Decisions 
regarding proceeding to each sequential cohort will be 
based on the recommendations of the Safety Review Team 
(SRT), consisting of external Retina Specialists and the 
Medical Monitor. The first subject of each dose cohort will 
be assessed by the SRT at 7 days after injection of RBM-
007 to determine if safety is acceptable. If so, RBM-007 
treatment will be given to the remaining 2 subjects in that 
dose cohort. Upon completion of the primary endpoint at 28 
days post-RBM-007 injection by all 3 subjects in the cohort, 
the SRT will review. If acceptable safety is seen, then the 
next dose cohort will be initiated, and the same schedule of 
interval SRT evaluations repeated for that cohort. Toxicity 
events observed in any subject will curtail treatment of 
other subjects in that cohort, as well as curtail progression 
to the next dose cohort. 
For eligibility, subjects age 55 years or older must be 
diagnosed with exudative AMD in the study eye, for which 

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previous standard treatment with intravitreal anti-vascular 
endothelial growth factor (anti-VEGF) agents has recently 
demonstrated incomplete resolution of exudation, as 
assessed by spectral domain optical coherence tomography 
(SD-OCT). Other inclusion criteria are: ETDRS best-
corrected visual acuity (BCVA) of 65 to 10 letters (≤20/50 
and ≥20/640 Snellen vision equivalent); presence of 
macular edema or subretinal fluid on SD-OCT; choroidal 
neovascular lesions ≤9 disc areas (DA); lesion composed 
of ≤50% subretinal hemorrhage 
Number of Subjects (planned): 
 
Approximately nine subjects (3 subjects per cohort) with 
exudative age-related macular degeneration will be enrolled at 
4-5 clinical trial sites. The final number of subjects enrolled 
may be adjusted based on the presence of dose limiting 
toxicities. 
Duration of the Study: 
 
Following a Screening Visit, at Baseline Visit (Day 0) the 
study eye will receive injection of RBM-007. The primary 
study endpoint will be at 28 days after RBM-007 injection, 
at which time anti-VEGF treatment can be resumed 
according to the investigating physician. Follow up will 
continue to the exit visit at 56 days. 
Diagnosis and Main Criteria for 
Inclusion:  
 
• 
Provide signed written informed consent on the IRB / 
EC approved Informed Consent Form (ICF) and 
provide authorization as appropriate for local privacy 
regulations. 
• 
Male or female 55 years of age or older on the date of 
signing the ICF and able and willing to comply with 
all treatment and follow-up study procedures. 
 
 
At Screening Visit, subjects must meet all the 
following inclusion criteria: 
• 
Must have had prior treatment in the study eye with 
any intravitreal anti-VEGF medication (at least 3 anti-
VEGF treatments within the prior 2-6 months), 
throughout which clinical examination and SD-OCT 
imaging has shown recurrent or persistent exudative 
activity, as shown by the presence of intraretinal or 
subretinal fluid, and/or subretinal exudation or 
hemorrhage. 
• 
BCVA of 65 to 10 ETDRS letters (20/50 to ≥20/640) 
in the study eye. 
• 
Presence of significant subretinal fluid and/or cystoid 
macular edema secondary to exudative age-related 
macular degeneration as assessed by SD-OCT in the 
study eye, with a minimum of 300 µm within the 
central subfield. 
• 
Total lesion size of ≤9 disc areas, lesion containing 
≤50% hemorrhage in the study eye. 
• 
Reasonably clear media and reasonable fixation ability 
in the study eye to allow for good quality SD-OCT 
and fundus photography. 
 
 

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At Baseline Visit (Day 0), subjects must meet all the 
following inclusion criteria: 
• 
BCVA of 65 to 10 ETDRS letters (20/50 to ≥20/640) 
in the study eye. 
• 
Presence of significant subretinal and/or intraretinal 
fluid secondary to exudative age-related macular 
degeneration as assessed by SD-OCT in the study eye, 
with a minimum of 300 µm within the central 
subfield. 
• 
Total lesion size of ≤9 disc areas, lesion containing 
≤50% hemorrhage in the study eye. 
 
Study Eye 
 
If both eyes of a subject meet the eligibility criteria, then study 
eye will be determined as the eye with the worse vision. If both 
eyes have the same vision, the right eye (OD) should be 
determined as the study eye. 
Investigational product, dosage and 
mode of administration: 
 
Subjects will receive one of the following three dose levels of 
the investigational product, RBM-007 injectable solution by 
intravitreal injection: 
0.2 mg (100 µL of 2 mg/mL) RBM-007 injectable solution 
1.0 mg (50 µL of 20 mg/mL) RBM-007 injectable solution 
2.0 mg (100 µL of 20 mg/mL) RBM-007 injectable solution 
Route of Administration of 
Investigational product:  
Single intravitreal injection in the study eye 
Criteria for Evaluation: 
 
Safety: The safety assessments will include adverse events 
(AEs), slit-lamp exam and biomicroscopy, indirect 
ophthalmoscopy, BCVA, IOP, fundus photography, fluorescein 
angiography, serum chemistry, hematology, vital signs, 
physical exam, EKG and pregnancy. 
Biological activity: The bioactivity of RBM-007 will be 
assessed using the change in retinal fluid measured by CST 
based on SD-OCT at each visit post RBM-007 treatment as 
compared to the Baseline Visit. 
Statistical Methods: 
 
Descriptive statistics will be provided for safety and bioactivity 
parameters by dose level. 
 
 
 

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TABLE OF CONTENTS 
 
INVESTIGATOR AGREEMENT........................................................................................................................ 2 
CONTACT INFORMATION AND PROTOCOL AUTHORIZATION ........................................................... 3 
ABBREVIATIONS AND TERMS ....................................................................................................................... 4 
1 
SYNOPSIS .................................................................................................................................................... 6 
2 
INTRODUCTION...................................................................................................................................... 12 
3 
OBJECTIVES ............................................................................................................................................ 13 
4 
INVESTIGATIONAL PLAN .................................................................................................................... 13 
4.1 
Overall Study Design and Plan ............................................................................................................ 13 
4.1.1 
Selection of Concentrations in the Study ....................................................................................... 14 
4.2 
Number of Subjects ............................................................................................................................... 15 
4.3 
Treatment Assignment .......................................................................................................................... 15 
4.4 
Dose Adjustment Criteria ..................................................................................................................... 15 
4.4.1 
Safety Criteria for Adjusting or Stopping Doses ........................................................................... 15 
4.5 
Criteria for Study Termination ............................................................................................................ 16 
4.6 
Study Procedures ................................................................................................................................... 16 
4.6.1 
Screening Phase ............................................................................................................................. 19 
4.6.1.1 
Screening Visit ..................................................................................................................... 19 
4.6.2 
Treatment/follow-up phase ............................................................................................................ 19 
4.6.2.1 
Baseline Visit (Day 0) .......................................................................................................... 19 
4.6.2.2 
Visit Day 1 ........................................................................................................................... 21 
4.6.2.3 
Visit Day 7 (Day 7±1) ......................................................................................................... 21 
4.6.2.4 
Visit Day 28 (Day 28±2) ..................................................................................................... 22 
4.6.3 
Study Exit ...................................................................................................................................... 22 
4.6.3.1 
Visit Day 56 (±3) .................................................................................................................. 22 
4.6.4 
Unscheduled Visits ........................................................................................................................ 23 
5 
SELECTION AND WITHDRAWAL OF SUBJECTS ............................................................................ 23 
5.1 
Subject Inclusion Criteria .................................................................................................................... 23 
5.2 
Subject Exclusion Criteria .................................................................................................................... 24 
5.3 
Subject Withdrawal Criteria ................................................................................................................ 25 
6 
TREATMENT OF SUBJECTS .............................................................................................................. 26 
6.1 
Description of Study Drug .................................................................................................................... 26 
6.2 
Concomitant Medications ..................................................................................................................... 26 
6.2.1 
Prohibited Medications or Treatments ........................................................................................... 26 
6.2.2 
Anti-VEGF treatment at Visit Day 28 (Day 28±2) and Visit Day 56 (Day 56±3) ....................... 26 
6.3 
Treatment Compliance.......................................................................................................................... 26 
6.4 
Randomization and Masking ............................................................................................................... 26 
7 
STUDY DRUG MATERIALS AND MANAGEMENT .......................................................................... 27 
7.1 
Study Drug ............................................................................................................................................. 27 
7.1.1 
Investigational Drug ...................................................................................................................... 27 
7.1.2 
Study Drug Complaint Reporting .................................................................................................. 27 
7.2 
Study Drug Packaging and Labeling ................................................................................................... 27 
7.3 
Study Drug Storage ............................................................................................................................... 27 
7.4 
Study Drug Preparation ....................................................................................................................... 27 
7.5 
Loading the Syringe .............................................................................................................................. 28 
7.6 
Eye Preparation ..................................................................................................................................... 28 
7.7 
Study Drug Administration .................................................................................................................. 28 
7.8 
Study Drug Accountability ................................................................................................................... 29 
7.9 
Study Drug Handling and Disposal ..................................................................................................... 29 

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8 
ASSESSMENT OF SAFETY .................................................................................................................... 29 
8.1 
Adverse Events ...................................................................................................................................... 29 
8.1.1 
Definition of Adverse Events ......................................................................................................... 29 
8.1.1.1 
Assessment of Adverse Events ............................................................................................. 30 
8.1.1.2 
Reporting Adverse Events .................................................................................................... 31 
8.1.2 
Serious Adverse Events ................................................................................................................. 32 
8.1.2.1 
Reporting Serious Adverse Events ....................................................................................... 32 
8.1.2.2 
Expedited Reporting of Serious Adverse Events.................................................................. 33 
8.1.3 
Events of Special Interest .............................................................................................................. 33 
8.1.4 
Follow-up of Adverse Events ........................................................................................................ 33 
8.1.5 
Manual Back-Up Reporting Procedures ........................................................................................ 33 
8.2 
Safety Parameters ................................................................................................................................. 34 
8.2.1 
Physical Examination .................................................................................................................... 34 
8.2.2 
Electrocardiogram (EKG) .............................................................................................................. 34 
8.2.3 
Vital Signs ..................................................................................................................................... 34 
8.2.4 
Best Corrected Visual Acuity ......................................................................................................... 34 
8.2.5 
Slit-lamp exam and Biomicroscopy ............................................................................................... 34 
8.2.6 
Intraocular Pressure ....................................................................................................................... 34 
8.2.7 
Indirect Ophthalmoscopy ............................................................................................................... 35 
8.2.8 
Serum Pregnancy Test ................................................................................................................... 35 
8.2.9 
Serum Chemistry, Hematology ...................................................................................................... 35 
8.2.10 
Fundus Photography ................................................................................................................. 35 
8.2.11 
Fluorescein Angiography ............................................................................................................... 35 
8.2.12 
OCT-Angiography .................................................................................................................... 35 
8.2.13 
Adverse Events ......................................................................................................................... 35 
9 
ASSESSMENT OF BIOACTIVITY ......................................................................................................... 35 
10 
OTHER ASSESSMENTS .......................................................................................................................... 36 
10.1 
Demographics and Baseline Characteristics .................................................................................. 36 
10.2 
Other Assessments ............................................................................................................................ 36 
11 
STATISTICAL METHODS ...................................................................................................................... 36 
11.1 
General Considerations.................................................................................................................... 36 
11.1.1 
Study Endpoints ............................................................................................................................. 36 
11.1.2 
Sample Size ................................................................................................................................... 36 
11.1.3 
Statistical Hypotheses and Level of Significance .......................................................................... 37 
11.1.4 
Randomization ............................................................................................................................... 37 
11.1.5 
Study Eye ....................................................................................................................................... 37 
11.2 
Study Populations ............................................................................................................................. 37 
11.3 
Handling of Missing Values ............................................................................................................. 37 
11.4 
Demographics and Baseline Characteristics .................................................................................. 37 
11.5 
Bioactivity Analyses .......................................................................................................................... 37 
11.6 
Safety Analysis .................................................................................................................................. 38 
12 
DIRECT ACCESS TO SOURCE DATA/DOCUMENTS ....................................................................... 38 
12.1 
Study Monitoring ............................................................................................................................. 38 
12.2 
Audits and Inspections ..................................................................................................................... 39 
12.3 
Institutional Review Board .............................................................................................................. 39 
13 
QUALITY CONTROL AND QUALITY ASSURANCE ........................................................................ 39 
13.1 
Quality Control ................................................................................................................................. 39 
13.2 
Quality Assurance ............................................................................................................................. 39 
14 
ETHICS ...................................................................................................................................................... 40 
14.1 
Ethics Review .................................................................................................................................... 40 
14.2 
Ethical Conduct of the Study ........................................................................................................... 40 
14.3 
Written Informed Consent .............................................................................................................. 40 

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15 
DATA HANDLING AND RECORDKEEPING ...................................................................................... 40 
15.1 
Inspection of Records ....................................................................................................................... 40 
15.2 
Retention of Records ........................................................................................................................ 40 
15.2.1 
Source Documents .................................................................................................................... 41 
15.2.2 
Data Collection ......................................................................................................................... 41 
16 
PUBLICATION POLICY ......................................................................................................................... 41 
17 
REFERENCES ........................................................................................................................................... 42 
List of Appendices 
APPENDIX 1: OBLIGATIONS OF INVESTIGATORS ............................................................................................. 44 
APPENDIX 2: ELEMENTS OF INFORMED CONSENT .......................................................................................... 46 
APPENDIX 3: DECLARATION OF HELSINKI ...................................................................................................... 48 
APPENDIX 4: PROCEDURES FOR EXAMINATIONS ............................................................................................ 53 
List of Tables 
TABLE 1: DOSE GROUPS AND ASSOCIATED RBM-007 CONCENTRATION ....................................................... 15 
TABLE 2: SCHEDULE OF EVENTS .................................................................................................................... 17 
TABLE 3: RBM-007 DOSING .......................................................................................................................... 27 
TABLE 4: PROTOCOL AMENDMENT 01 SUMMARY OF CHANGES ..................................................................... 59 
List of Figures 
FIGURE 1: DOSE ESCALATION SEQUENCE SCHEMA ........................................................................................ 14 

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2 INTRODUCTION 
RBM-007 injectable solution is a novel oligonucleotide-based aptamer having potent anti-
FGF2 activity (Jin et al, 2016) and anti-VEGF-expression activity (Belgore et al, 2003). In 
the rat and mouse models of laser-induced choroidal neovascularization, it showed activity 
after intravitreal injection at doses as low as 5 µg/eye. In the laser-induced choroidal 
neovascularization (CNV) fibrosis model in rats, it showed activity after intravitreal 
injection at doses as low as 15 µg/eye. It is hypothesized to have potential effects in the 
treatment of wet age-related macular degeneration (AMD) because of these activities. Thus, 
the Sponsor plans to evaluate the safety and bioactivity of RBM-007 Injectable Solution as 
an intravitreal treatment for exudative AMD. 
In this submission, the Sponsor provides nonclinical pharmacology, pharmacokinetic and 
toxicology information and chemistry, manufacturing and control (CMC) to support the 
intended clinical evaluation of RBM-007 Injectable Solution in patients with wet AMD. 
Approximately 1.2 million persons in the United States are estimated to have neovascular 
AMD and 970 000 to have geographic atrophy; >8 million have at least large drusen in 1 
eye and 3.6 million of these have bilateral large drusen.  
Without methods to slow AMD progression over the next 20 years, these prevalence figures 
are expected to increase by approximately 50% (Chew et al, 2012; Friedman et al, 2004). 
From the initial stage of dry AMD, characterized by lipofuscin deposits under the retina 
known as drusen, 10% are at risk for severe, acute loss of central vision due to the onset of 
wet AMD, characterized by the growth of abnormal CNV in the macula, which leads to 
subretinal bleeding, fluid exudation, and fibrotic scar formation. Over 200,000 new patients 
each year in the U.S. develop wet AMD (Ferris, et al, 1984). 
Current FDA-approved therapies for AMD are pegaptanib (Macugen®), ranibizumab 
(Lucentis®) and aflibercept (Eylea®). Also used off-label is aliquoted bevacizumab 
(Avastin®). All of these molecules act against the same target: vascular endothelial growth 
factor (VEGF). VEGF, a potent endothelial cell mitogen and vascular permeability factor, is 
a major contributor to the pathogenesis of neovascular AMD. Treatments with anti-VEGF 
drugs, which are delivered by frequent intravitreal injections, have shown dramatic visual 
benefits for AMD patients (Brown et al, 2006; Heier et al, 2012; Martin et al, 2012). 
However, there are some critical limitations; in formal clinical trials, despite consistent 
monthly treatment, 23% of eyes treated monthly with ranibizumab proceeded to vision 
worse than 20/200, and 20% to 40% fail to resolve macular fluid even after 2 years of 
therapy (Brown et al, 2006; Heier et al, 2012). Furthermore, in the “real-world” setting, 
patients receive intravitreal injections at much lower frequency than the established 
protocols, so that on average, long-term visual outcomes in AMD treatment are poor 
(Rofagha et al, 2013; Maguire et al, 2016). Factors associated with poor vision outcomes, in 
addition to persistent exudation, include macular atrophy and submacular fibrotic scar 
formation. Thus, there is a need for additive or alternative therapy to anti-VEGF treatments 
for wet AMD. 
Fibroblast growth factor (FGF) has been implicated in the pathophysiology of both 
angiogenesis and fibrosis in retinal diseases (Schultz and Grant, 1991; Vinding, 1990). FGF 
comprises a family of 22 members, including FGF2, having many biological activities 
(Bikfalvi et al., 1997). FGF2 promotes growth of vascular endothelial cells and tubular 
structure formation (Strutz et al, 2002), and stimulates both VEGF production and scar 
formation in retina.  

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3 OBJECTIVES 
Primary Objective: 
To assess the safety and tolerability of a single intravitreal injection of three dose levels of 
RBM-007 (0.2 mg/eye, 1.0 mg/eye and 2.0 mg/eye) in subjects with exudative age-related 
macular degeneration. 
Secondary Objective: 
To evaluate the bioactivity of three dose levels of RBM-007 in subjects with exudative age-
related macular degeneration. 
4 INVESTIGATIONAL PLAN 
4.1 
Overall Study Design and Plan 
This is an open label, dose-escalating, sequential cohort study assessing the safety, 
tolerability, and biological activity of a single i.vt. injection of 0.2 mg, 1.0 mg and 2.0 mg 
RBM-007 administered in a total of approximately nine subjects with exudative AMD. 
Nine subjects in three dose cohorts (3 subjects each cohort) will receive a single i.vt. 
injection of RBM-007 in the study eye. Decisions regarding dose escalation will be based 
on the recommendations of the Safety Review Team consisting of external Retina 
Specialists and the Medical Monitor. Dose-Limiting Toxicity response observed in any 
cohort will result in termination of the dose escalation. 
The study is designed to include a primary endpoint at Day 28 following RBM-007 
injection, and Day 56 follow-up for each subject. 
Subjects eligible for the study are 55 years or older with exudative AMD. The study eye 
must have a history of having received at least 3 intravitreal anti-VEGF treatments 
(ranibizumab, aflibercept, and/or bevacizumab) without resolution of exudation (persistent 
or recurrent subretinal and/or intraretinal fluid on SD-OCT), with such fluid present at the 
Screening Visit and at the Baseline Visit (Day 0). Leading up to the Baseline Visit, there is a 
minimum 4-week washout period in which the study eye has received no anti-VEGF 
injections or other treatments for exudative AMD.  
The first eligible subject in Cohort 1 will receive a single i.vt. injection of 0.2 mg RBM-007 
in the study eye at Baseline Visit (Day 0) and will be evaluated through Visit Day 7 (±1). 
The Safety Review Team will assess the safety and tolerability of the RBM-007 in the first 
subject of the cohort. If satisfactory, RBM-007 will be given to the remaining 2 subjects in 
that dose cohort. After all 3 subjects in the Cohort 1 have completed Visit Day 28 (±2), the 
Safety Review Team will again assess safety and tolerability. When the safety and 
tolerability of the lower dose have been deemed acceptable, dosing of the first subject in the 
next cohort will begin. The same treatment sequence and interval SRT evaluations will be 
followed for Cohort 2 (1.0 mg of RBM-007), and Cohort 3 (2.0 mg of RBM-007). 
At Visit Day 7 (±1), study eyes may receive rescue treatment with i.vt. anti-VEGF, 
based on worsening from baseline according to criteria or investigator discretion (See 
Section 4.6.3). All subjects may resume i.vt. anti-VEGF treatment 28 days after RBM-007 
i.vt. injection, at or after Visit Day 28 (±2). 
Randomization is not employed in this study due to the small sample size and the dose-
escalating design. Refer to Figure 1 for a pictorial representation of the study design. 

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Figure 1: Dose Escalation Sequence Schema 
 
4.1.1 Selection of Concentrations in the Study  
A wide range of animal toxicology studies were conducted with RBM-007 Injectable 
Solution by both systemic and ocular routes. Systemic toxicity was seen only with high 
doses far above those doses contemplated for ocular administration. The NOAEL in GLP 
intravitreal monkey studies is 1 mg/eye. Using a volume of vitreous of 2.2 mL for monkey, 
this is a concentration of 0.45 mg/mL (Atsumi et al, 2013). The intended human doses for 
the first in human study (RBM-007-001) are 0.2 mg, 1.0 mg and 2.0 mg per eye 
administered once. Considering a value of human vitreous to be 5.2 mL (Panda-Jonas, 
1994), these concentrations are 0.038, 0.19 and 0.38 mg/mL for these clinical doses. 
Therefore, the NOAEL in monkey is 11-fold higher than the intended starting clinical dose 
and 1.1-fold higher than intended maximum human dose. The safety factor would have 
been even higher if the viscosity and injectable volume for RBM-007 Injectable Solution in 
animals (monkey and rabbit) were not limiting parameters. It should also be noted that the 
clinical protocol requires the review of safety data for each cohort (and also first patient in 
each cohort) by a Safety Review Team independent of Principal Investigators before 
escalating the clinical dose. 
With regard to systemic exposure, the highest concentration of RBM-007 seen in plasma 
after single intravitreal dosing was 1,560 ng/mL at a dose of 1 mg/eye in monkey and 
65.1 ng/mL at a dose of 0.5 mg/eye (injection to both eyes at a dose of 0.5 mg/eye, total 1 
mg/body) in rabbit. Toxicokinetic evaluation in GLP systemic studies in monkey suggests 
that blood level at which toxicity might occur is 691,000 ng/mL. Thus, even without 
correcting for the body weight differences between animals and humans, the safety margin 
is 221–5,307 at the maximum dose of 2.0 mg/eye for human. If the body weight for animals 

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is taken into account (rabbit and monkey at 3 Kg and human at 70 Kg.), the safety margin is 
5,156–123,830. Thus, the Sponsor contends that the preclinical toxicology studies support 
the planned clinical studies. 
4.2 
Number of Subjects 
Approximately nine subjects (3 subjects per cohort) with exudative age-related macular 
degeneration will be enrolled at 4-5 clinical sites. The final number of subjects enrolled 
may be adjusted based on the presence of dose limiting toxicities. 
4.3 
Treatment Assignment 
Three dose levels will be administered by a single i.vt. injection in the study eye as noted in 
Table 1. 
Table 1: Dose Groups and Associated RBM-007 Concentration 
Dose Group 
RBM-007 Concentration 
Cohort 1: 0.2 mg 
100 microliters of 2 mg/mL RBM-007 
Cohort 2: 1.0 mg 
50 microliters of 20 mg/mL RBM-007 
Cohort 3: 2.0 mg 
100 microliters of 20 mg/mL RBM-007 
4.4 
Dose Adjustment Criteria 
The Safety Review Team will review safety parameters after the first subject in each cohort 
has completed Visit Day 7. The remaining 2 subjects in the cohort will receive the same 
dose if neither the safety criteria for adjusting or stopping doses (Section 4.4.1) nor the 
criteria for study termination (Section 4.5) preclude their treatment. 
When all subjects in the cohort have completed Visit Day 28, the Safety Review Team will 
again evaluate the safety parameters. If the safety criteria for adjusting or stopping doses 
and the criteria for study termination are not met, the first subject in the next cohort will 
receive the next higher RBM-007 dose level. 
The same treatment sequence and interval safety evaluations will be performed for each 
cohort. 
4.4.1 Safety Criteria for Adjusting or Stopping Doses 
If more than one of the following dose limiting toxicities is observed in any one cohort, 
planned doses may be adjusted or stopped by the Safety Review Team. 
• Visual acuity loss from Baseline Visit defined as: 
• Loss of best corrected visual activity (BCVA) of 15 or more letters OR 
• Progression to no light perception vision (NLP) not due to injection procedure 
• Clinically significant inflammation defined as: 
• Anterior chamber cell and/or flare of grade 2+ or more OR 
• >3+ vitreous haze as measured by the National Eye Institute Grading Scheme 
(Nussenblatt et al., 1985) OR 

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• Sterile endophthalmitis (including the presence of hypopyon) 
• Severe Intraocular Pressure (IOP) elevation as measured by tonometry, on two separate 
exams, at least one day apart, excluding day of injection (despite pharmaceutical 
intervention): 
• >30 mmHg OR 
• Increase of > 15 mmHg from baseline 
If any of the following adverse events (AEs) occur in any one subject in any cohort, 
planned doses will be adjusted by treating additional subjects at the same or lower dose 
level (the occurrence of a second adverse event in either the same or different subjects in 
one cohort will qualify for study termination, Section 4.5): 
• Retinal non-perfusion/vascular occlusion of the study eye 
• Retinal vasculitis 
• Retinitis 
• 2+ disc edema 
• > 2 quadrants of retinal hemorrhage 
If there is insufficient safety information in a given cohort at any time, the Safety Review 
Team may determine to treat additional subjects within that cohort before moving to the 
next cohort. 
4.5 
Criteria for Study Termination 
Unacceptable safety signals will prevent moving to the next higher dose cohort or result in 
stopping the study, including any of the following, if deemed to be related to study drug 
RBM-007 (distinct from complications related to the i.vt. injection procedures): 
• A pattern of systemic AEs 
• Any of the following AEs in any 2 subjects in any cohort: 
• Retinal non-perfusion/vascular occlusion of the study eye 
• Retinal vasculitis 
• Retinitis 
• > 2+ disc edema 
• > 2 quadrants of retinal hemorrhage 
4.6 
Study Procedures 
All subjects must sign a written informed consent before participating in any study-related 
activity. Enrollment will occur at Baseline Visit (Day 0) after a subject meets all eligibility 
requirements at Screening Visit and Baseline Visit (Day 0). Each enrolled subject will be 
assigned a unique subject number. If a subject is discontinued from the study for any 
reason, the subject number will remain in effect and will not be reused. 
A Schedule of Events can be found below and detailed procedures for examinations can be 
found in Appendix 4. 

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Table 2: Schedule of Events 
Visit Number 
Screening 
Visit 
Baseline  
Visit 
Visit  
Day 
1 
Visit  
Day 
7 
Visit  
Day 
28 
Visit  
Day 
56 
Visit Schedule 
 (Time window; days)  
 
Day 0 
Day 
1 
Day 
7 
(±1) 
Day 
28 
(±2) 
Day 
56 
(±3) 
RBM-007 
injection 
Pre 
Post 
Informed consenta 
X 
 
 
 
 
 
 
Demographics/Eligibility 
X 
 
 
 
 
 
 
AMD Treatment history review 
X 
X 
 
 
 
 
 
Medical/surgical history, Concomitant 
medication 
X 
 
 
 
 
 
 
Physical exam 
X 
 
 
 
 
 
X 
Vital signs 
X 
X 
 
X 
X 
X 
X 
EKG 
X 
 
 
 
 
 
 
BCVA (ETDRS) 
X 
X 
 
X 
X 
X 
X 
Slit-lamp exam and biomicroscopyb 
X 
X 
X 
X 
X 
X 
X 
Intraocular pressurec 
X 
X 
X 
X 
X 
X 
X 
Indirect ophthalmoscopyb 
X 
X 
X 
X 
X 
X 
X 
SD-OCT 
X 
X 
 
X 
X 
X 
X 
Fundus photography  
 
X 
 
 
 
X 
X 
Fluorescein angiography 
 
X 
 
 
 
X 
X 
OCT-angiography 
 
X 
 
 
 
X 
X 
Serum pregnancy testd 
X 
 
 
 
 
 
 
Hematology, serum chemistrye 
X 
 
 
 
 
X 
 
Plasma RBM-007 levelf 
 
 
X 
X 
X 
X 
 
RBM-007 i.vt. Injection 
 
X 
 
 
 
 
Anti-VEGF rescue treatmentg 
 
 
 
X 
 
 
Option Anti-VEGF Injectionh  
 
 
 
 
 
X 
X 
Adverse events 
 
 
X 
X 
X 
X 
X 
 

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a 
Informed Consent Form - obtain prior to conducting any study-related activities. 
b 
Slit-lamp exam and biomicroscopy and indirect ophthalmoscopy at Baseline Visit (Day 0) will be 
performed prior to RBM-007 injection and within 30 minutes after injection. 
c 
IOP measurement will be performed before RBM-007 Intravitreal injection and 30±10 minutes after 
injection. If IOP is increased ≥10 mmHg above pre-injection baseline, repeat IOP measurement is to be 
done 60±10 minutes after the injection. 
d 
Serum pregnancy tests are to be performed on all women of child-bearing potential. 
e 
Order blood tests at local laboratory; review results. 
f 
Collect blood specimen for RBM-007 plasma drug level 1 hour after RBM-007 injection; document time 
of both RBM-007 injection and post-injection blood draw.  
g 
Visit Day 7 anti-VEGF rescue based on rescue criteria: compared to Baseline Visit (Day 0) there is: 1) 
worsening of BCVA from Baseline Visit (Day 0) of more than 10 ETDRS letters, or 2) increased 
thickness in the central subfield of more than 100 µm. Clinical Investigator may also rescue if it is 
required by their clinical assessment. For rescue, the investigator may use ranibizumab, aflibercept or 
bevacizumab at their choice. 
h 
Clinical Investigator may resume intravitreal anti-VEGF injection at their clinical discretion, using 
ranibizumab, aflibercept or bevacizumab at their choice. 
 

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4.6.1 Screening Phase 
4.6.1.1 Screening Visit   
• Treatment History Review: 
• Ascertain the patient has exudative AMD that has not resolved with anti-VEGF 
therapy: 
• Minimum of 3 prior anti-VEGF injections within the past 2-6 months, DURING 
WHICH 
• SD-OCT has shown recurrent or persistent macular fluid despite this anti-VEGF 
treatment, defined as the presence of significant subretinal fluid or cystoid macular 
edema, with macular thickness a minimum of 300 µm within the central macular 
subfield 
• Discuss the purpose and details of the study to the subject and obtain written informed 
consent prior to the subject's participation in any study related activity. 
• Review subject's demographic information, medical, surgical and medication history. 
• Perform the following: (all ophthalmic procedures to be performed OU) 
• Physical examination 
• Blood Pressure, Pulse Rate 
• EKG 
• BCVA (ETDRS) 
• Slit-lamp exam and biomicroscopy 
• IOP 
• Indirect ophthalmoscopy 
• SD-OCT 
• Review the inclusion and exclusion criteria. Do not continue screening any subject who 
does not meet the screening eligibility requirements. 
• If the subject continues to be eligible for the study, order and review the following tests 
to be performed at a local laboratory: 
• Serum pregnancy test (for females of child-bearing potential) 
• Hematology, serum chemistry 
• Upload all collected images  to Sponsor or representative. 
• Schedule the subject to return for Baseline Visit (Day 0). 
4.6.2 Treatment/follow-up phase 
4.6.2.1 Baseline Visit (Day 0) 
• Review results of the evaluations and tests performed at Screening Visit to determine 
continuation in the study 

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• Treatment History Review: 
• Confirm that the study eye has not received any anti-VEGF injection or other AMD 
therapy for at least 4 weeks prior to Baseline Visit/RBM-007 injection 
• Perform the following assessments: (all ophthalmic procedures to be performed OU) 
• Vital signs: Blood Pressure, Pulse Rate 
• BCVA (ETDRS) 
• Slit-lamp exam and biomicroscopy 
• IOP 
• Indirect ophthalmoscopy 
• SD-OCT 
• Fundus photography 
• Fluorescein angiography 
• OCT-angiography 
• Perform final review of inclusion/exclusion criteria. If the subject meets all eligibility 
criteria, determine the study eye (Section 11.1.5). 
• Perform intravitreal injection of RBM-007 to the study eye (according to steps 
described in Section 7): 
• Prepare the RBM-007 (Section 7.4) 
• Load the syringe (Section 7.5) 
• Prepare the eye including ocular antisepsis of study eye (Section 7.6) 
• Administer RBM-007 (Section 7.7) 
• Document time of RBM-007 injection 
• Assess for Count Fingers vision 1 to 5 minutes post-injection 
• The following assessments must be performed after the administration of RBM-007: 
• WITHIN 30 MINUTES following RBM-007 injection 
• Slit-lamp exam and biomicroscopy 
• Indirect ophthalmoscopy 
• AT 30 (±10) MINUTES FOLLOWING RBM-007 injection, measure IOP in study eye 
• If post-injection IOP is increased ≥10 mmHg from pre-injection IOP, the IOP will 
be measured gain 60 (±10) minutes following injection. If there is an increase of 
≥10 mmHg at 60 (±10) minutes post-injection compared to pre-injection IOP, the 
subject should be prescribed a topical IOP-lowering medication and monitored for 
resolution of the event by the Clinical Investigator. An IOP increase of ≥10 mmHg 
shall be reported as an AE. 
• AT 60 (±10) MINUTES FOLLOWING RBM-007 injection, collect blood specimen for 
RBM-007 plasma level 
• Document time of blood specimen collection 
• AE assessments must be performed after the RBM-007 administration 

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• Upload all collected images to Sponsor or representative 
• Schedule the subject to return for Visit Day 1 (following day). 
4.6.2.2 Visit Day 1 
Perform the following assessments: 
• Query for AEs 
• Vital signs (Blood Pressure, Pulse Rate)  
• BCVA (ETDRS) 
• Slit-lamp exam and biomicroscopy 
• IOP 
• Indirect ophthalmoscopy 
• SD-OCT 
• Collect Blood Specimen for RBM-007 plasma level 
• Upload all collected images to Sponsor or representative. 
• Schedule the subject to return for the Visit Day 7 (±1). 
4.6.2.3 Visit Day 7 (Day 7±1) 
Perform the following assessments: 
• Query for AEs 
• Vital signs (Blood Pressure, Pulse Rate) 
• BCVA (ETDRS) 
• Slit-lamp exam and biomicroscopy 
• IOP 
• Indirect ophthalmoscopy 
• SD-OCT 
• Collect blood specimen for RBM-007 plasma levels 
• Review Rescue Criteria for anti-VEGF intravitreal injection in study eye 
• Rescue Criteria: 
• Vision loss in study eye from Baseline Visit of more than 10 ETDRS letters 
• Increase from Baseline Visit of more than 100 µm in the central subfield on SD-
OCT 
• Clinical investigator assessment that rescue with standard therapy is indicated  
IF RESCUE CRITERIA ARE MET, proceed with intravitreal injection of anti-VEGF in 
study eye. Clinical Investigator may select which intravitreal anti-VEGF injection to use at 
their clinical discretion, using ranibizumab, aflibercept or bevacizumab at their choice. 
• Any anti-VEGF injection should be performed only after all evaluations and 
procedures for the study visit are completed. 

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• Upload all collected images to Sponsor or representative. 
• Schedule the subject to return for Visit 28 (Day 28±2)． 
4.6.2.4 Visit Day 28 (Day 28±2) 
The following assessments must be performed, prior to optional administration of anti-
VEGF medication at investigator discretion: 
• Query for AEs 
• Vital signs (Blood Pressure, Pulse Rate) 
• BCVA (ETDRS) 
• Slit-lamp exam and biomicroscopy 
• IOP 
• Indirect ophthalmoscopy 
• SD-OCT 
• Fundus photography 
• Fluorescein angiography 
• OCT-angiography 
• Collect blood specimen for RBM-007 plasma level 
• Order and review the following tests to be performed at local laboratory: 
• hematology and serum chemistry. 
• At completion of the study visit, the clinical Investigator may resume intravitreal anti-
VEGF injection at their clinical discretion, using ranibizumab, aflibercept or 
bevacizumab at their choice. 
• Any anti-VEGF treatment should be performed only after completing all 
evaluations and procedures for the study visit 
• Upload all collected images  to Sponsor or representative. 
• Schedule the subject to return for Visit Day 56 (±3). 
4.6.3 Study Exit 
4.6.3.1 Visit Day 56 (±3) 
Perform the following assessments:  
• Query for AEs  
• Physical exam  
• Vital signs (Blood Pressure, Pulse Rate) 
• BCVA (ETDRS) 
• Slit-lamp exam and biomicroscopy 
• IOP 
• Indirect ophthalmoscopy 

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• SD-OCT 
• Fundus photography  
• Fluorescein angiography 
• OCT angiography 
• At completion of the study visit, the clinical Investigator may administer intravitreal 
anti-VEGF injection at their clinical discretion, using ranibizumab, aflibercept or 
bevacizumab at their choice. 
• Any anti-VEGF treatment is performed only after completing all other evaluations 
and procedures for the study visit 
• Upload all collected images to Sponsor or representative. 
• Exit subject from study. 
4.6.4 Unscheduled Visits 
If a subject requires evaluation between scheduled visits, complete all applicable study 
specified procedures as necessary and record the information on the Unscheduled Visit 
form. 
5 SELECTION AND WITHDRAWAL OF SUBJECTS 
Eligible subjects must meet all eligibility criteria described in this section. 
5.1 
Subject Inclusion Criteria 
Provide signed written informed consent on the IRB / EC approved Informed Consent 
Form (ICF) and provide authorization as appropriate for local privacy regulations. 
1. Male or female 55 years of age or older on the date of signing the ICF and able and 
willing to comply with all treatment and follow-up study procedures. 
 
 
At Screening Visit, subjects must meet all the following inclusion criteria: 
2. Must have had prior treatment in the study eye with any intravitreal anti-VEGF 
medication (at least 3 anti-VEGF treatments within the prior 2-6 months), throughout 
which clinical examination and SD-OCT imaging has shown recurrent or persistent 
exudative activity, as shown by the presence of intraretinal or subretinal fluid, and/or 
subretinal exudation or hemorrhage. 
3. BCVA of 65 to 10 ETDRS letters (20/50 to ≥20/640) in the study eye. 
4. Presence of significant subretinal fluid and/or cystoid macular edema secondary to 
exudative age-related macular degeneration as assessed by SD-OCT in the study eye, 
with a minimum of 300 µm within the central subfield. 
5. Total lesion size of ≤9 disc areas, lesion containing ≤50% hemorrhage in the study 
eye.  
6. Reasonably clear media and reasonable fixation ability in the study eye to allow for 
good quality SD-OCT and fundus photography.  
 
At Baseline Visit (Day 0), subjects must meet all the following inclusion criteria: 
7. BCVA of 65 to 10 ETDRS letters (20/50 to≥ 20/640) in the study eye. 
8. Presence of significant subretinal and/or intraretinal fluid secondary to exudative age-
related macular degeneration as assessed by SD-OCT in the study eye, with a minimum 
of 300 µm within the central subfield. 

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9. Total lesion size of ≤ 9 disc areas, lesion containing ≤ 50% hemorrhage in the study 
eye. 
5.2 
Subject Exclusion Criteria 
A subject with any of the following conditions is not eligible to participate in the study:  
Ocular exclusion criteria: 
1. BCVA better than 65 ETDRS letters (20/50) in the study eye. 
2. BCVA worse than 10 ETDRS letters (20/640) in the study eye. 
3. Fellow eye BCVA worse than 35 ETDRS letters (20/200). 
 
Use of any of the following treatments to the study eye: 
4. Intravitreal anti-VEGF injection (ranibizumab, aflibercept or bevacizumab) in the study 
eye within the past 4 weeks or less prior to Baseline Visit and RBM-007 injection.  
5. Intravitreal or periocular corticosteroid, within 3 months prior to Baseline Visit (Day 0) 
and throughout the study; 
6. Fluocinolone acetonide intravitreal implant, within 12 months prior to Baseline Visit 
(Day 0) and throughout the study; 
7. Visudyne® (verteprofin) photodynamic therapy, within 3 months prior to Baseline Visit 
(Day 0) and throughout the study. 
8. Uncontrolled or advanced glaucoma, defined by an intraocular pressure (IOP) of >21 
mmHg or cup/disc ratio > 0.8 while on medical therapy, or chronic ocular hypotony (<6 
mmHg) in the study eye. 
9. Evidence of ocular disease other than exudative AMD in the study eye that may 
confound the outcome of the study (e.g., active diabetic retinopathy, posterior uveitis, 
adult vitelliform dystrophy, moderate/severe myopic degeneration). 
10. History of vitrectomy surgery in the study eye. 
11. Anticipated need for any ocular surgery involving the study eye during the course of the 
study. 
12. Nd:YAG laser capsulotomy within 28 days prior to Baseline Visit (Day 0) in the study 
eye. 
13. Intraocular surgery, including lens removal or ophthalmologic laser procedure, within 
90 days prior to Baseline Visit (Day 0) in the study eye. 
14. Ocular or periocular infection in either eye. 
15. Pupillary dilation inadequate for good quality fundus photography in the study eye. 
16. Media opacity that would limit clinical visualization, fundus photography, fluorescein 
angiography, or SD-OCT evaluation in the study eye. 
17. History of herpetic ophthalmic infection in the study eye or adnexa. 
18. Presence of known toxoplasmosis or toxoplasmosis scar in either eye. 
19. Presence or history of any form of ocular malignancy including choroidal melanoma in 
the study eye.  
 
 
Non-Ocular exclusion criteria: 
20. Systemic treatment with anti-VEGF agents (e.g., intravenous bevacizumab). 
21. Allergy or hypersensitivity to study drug product, fluorescein dye, or other study related 
procedures/medications. 
22. Inadequate renal function: serum creatinine > 1.3 mg/dL and BUN > 2 x the the upper 
limit of normal (ULN). 
23. Inadequate hematologic function: hemoglobin < 12 g/dL; platelet count < 130 x 109 /L; 
WBC < 3.5 x 109 /L or> 10.5 x 109 /L. 

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24. Inadequate liver function: serum bilirubin > 1.5 mg/dL, GGT, SGOT/ALT, SGPT/AST, 
and alkaline phosphatase outside 2 x ULN.  
25. Myocardial infarction, stroke or history of transient ischemic attacks within 180 days 
prior to Baseline Visit (Day 0). 
26. Major surgery within 90 days prior to Baseline Visit (Day 0). Major surgery is defined 
as any surgery involving a risk to the life of the subject, including any operation upon 
an organ within the cranium, chest, abdomen, or pelvic cavity. 
27. Therapeutic radiation to the head or neck within 90 days prior to Baseline Visit (Day 0). 
28. Participation in other investigational drug or device clinical trials within 30 days prior 
to Baseline Visit (Day 0) or planning to participate in other investigational drug or 
device clinical trials for the duration of the study. This includes both ocular and non-
ocular clinical trials. 
29. Uncontrolled blood pressure (defined as systolic >180 mmHg and/or diastolic >110 
mmHg while subject is sitting). If a subject's initial reading exceeds these values, a 
second reading may be taken 30 or more minutes later. If a subject's blood pressure 
needs to be controlled by antihypertensive medication, the subject can be eligible if 
medication is taken continuously for at least 30 days prior to Baseline Visit (Day 0). 
30. Atrial fibrillation not controlled by treatment under the care of the subject's primary 
care physician or cardiologist within 30 days prior to Baseline Visit (Day 0). 
31. Clinically significant concurrent illness, laboratory or EKG abnormality. 
32. History of other disease, metabolic dysfunction, physical examination finding, or 
clinical laboratory finding giving reasonable suspicion of a disease condition that 
contraindicates the use of an investigational drug, might affect the interpretation of the 
results of the study, or renders the subject at high risk for treatment complications. 
33. Any systemic infection within 30 days prior to Baseline Visit (Day 0). 
34. Unable to comply with study procedures or follow-up visits. 
35. In addition, the Clinical Investigator or Medical Monitor may declare a subject 
ineligible for any sound reason. 
5.3 
Subject Withdrawal Criteria 
An early termination occurs when a subject who provides written informed consent ceases 
participation in the study, regardless of circumstances, before the completion of the study. 
Subjects may voluntarily withdraw from the study at any time for any reason. In addition, 
the Clinical Investigator or the Medical Monitor may terminate a subject's study 
participation for reasons related to the best interest of the subject. Subjects who terminate 
from the study may be replaced. Subjects may be terminated from the study due to any of 
the following reasons: 
1. Non-compliance 
2. Lost to follow-up 
3. Protocol violation 
4. Withdrawal by subject 
5. AEs 
6. Death 
7. Other 
If a subject is discontinued from the study before completing Visit Day 56 (±3), then to the 
extent possible, all assessments, including safety, that are scheduled to be performed at 
Visit Day 56 exit should be performed on the day of discontinuation. 
Subjects who discontinue prematurely may be replaced with prior approval from Sponsor. 

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6 TREATMENT OF SUBJECTS 
6.1 
Description of Study Drug 
RBM-007 is a pegylated oligonucleotide-based aptamer. RBM-007 injectable solution is a 
formulation designed for intravitreal injection. 
6.2 
Concomitant Medications 
The use of any concomitant prescription or over-the-counter medication will be recorded 
during the study. Therapy considered necessary for the subject's welfare may be given at the 
discretion of the Clinical Investigator during the study. Whenever possible, concomitant 
medications should be administered in dosages that remain constant throughout the study. 
The generic name, indication, route of administration, frequency, dose, start date and stop 
date (if applicable) will be recorded for each medication. 
6.2.1 Prohibited Medications or Treatments 
Any treatments for exudative AMD in the study eye other than RBM-007 are prohibited 
during the study, except anti-VEGF treatment as a rescue therapy at Visit Day 7 (Day 7±1) 
and/or resumption of anti-VEGF treatment at Visit Day 28 (Day 28±2) and/or Visit Day 56 
(Day 56±3), as described in Section 6.2.2.  
Any systemic treatments with anti-VEGF agents (e.g., intravenous bevacizumab) are 
prohibited during the study. 
The decision to administer a prohibited concomitant medication or treatment during the 
study should be made with the safety of the subject as the primary consideration. Whenever 
possible, RIBOMIC should be notified before any prohibited medication or treatment is 
administered or if the permissibility of a specific medication or treatment is in question. 
6.2.2 Anti-VEGF treatment at Visit Day 28 (Day 28±2) and Visit Day 56 (Day 56±𝟑𝟑) 
For subjects who did not receive rescue therapy with anti-VEGF medication at Visit Day 7 
(Day 7±1), on Visit Day 28 (28±2) the study eye may be considered at investigator 
discretion to receive i.vt. anti-VEGF treatment after completion of evaluations and 
procedures for Visit Day 28 (28±2). Selection of which anti-VEGF agent to administer is at 
the clinical investigator’s decision. Similarly, at Exit Visit (Day 56±3), the study eye may 
receive i.vt. anti-VEGF at investigator discretion after completion of evaluations and 
procedures for Exit Visit (Day 56±3). 
6.3 
Treatment Compliance 
To obtain reliable safety and bioactivity data, it is critical that the treatment regimen and 
visit schedule specified in this protocol are followed. The Clinical Investigator is required 
to administer the RBM-007 injection and is responsible for scheduling the subject for 
follow-up visits as specified in the protocol. Study monitors will verify pertinent data to 
confirm the study is conducted according to the protocol. 
6.4 
Randomization and Masking 
Randomization is not employed in this study due to the small sample size and the open-
label, dose-escalating design. 

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7 STUDY DRUG MATERIALS AND MANAGEMENT 
7.1 
Study Drug 
7.1.1 Investigational Drug 
RBM-007 for i.vt. injection is formulated in a proprietary, clear, aqueous solution at two 
concentrations. The three dose levels of RBM-007 to be administered in the study eye are 
shown in Table 3. 
Table 3: RBM-007 Dosing 
Injection Volume of: 
Will deliver approximately: 
100 microliters of 2 mg/mL RBM-007 
0.2 mg RBM-007 
50 microliters of 20 mg/mL RBM-007 
1.0 mg RBM-007 
100 microliters of 20 mg/mL RBM-007 
2.0 mg RBM-007 
i 
The Clinical Investigator will use syringes and needles supplied by RIBOMIC /Representative. 
7.1.2 Study Drug Complaint Reporting 
Complaints regarding the RBM-007 for i.vt. injection should be reported to RIBOMIC 
Product Complaint at (707) 287 4313. 
7.2 
Study Drug Packaging and Labeling 
RBM-007 injectable solutions are filled (0.5 mL fill) in 2-mL Type 1 Glass (borosilicate) 
clear vials, capped with 13 mm Gray Butyl stoppers with B2-40 coating (on top) and 
FluroTec coating (on bottom), and sealed. Each single use vial will be placed in a unit 
carton, and the labeling will include protocol number, kit number, and storage conditions. 
7.3 
Study Drug Storage 
RBM-007 injectable solutions will be provided by RIBOMIC/Representative and will be 
stored in an appropriate secure area at the investigational site. RBM-007 vials should be 
protected from light, stored upright, and kept at -20°C. 
7.4 
Study Drug Preparation 
Once an investigational drug vial number has been assigned to the subject, the vial of 
investigational drug with the assigned vial number will be removed from the freezer. The 
contents should be thawed by rotating the vials between the palms of the hands, or by 
setting the vial at room temperature. Care should be taken to protect the product from light.  
Investigational drug should be used for intravitreal injection in the study subject within 1 
hour after removing the vial from the freezer. 
Each vial contains enough RBM-007 to inject one subject. Each vial will be used one time 
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7.5 
Loading the Syringe 
A sterile, single-use syringe will be provided separately for i.vt. injection of RBM-007. 
Instructions for filling the syringe are as follows: 
• Remove the sterile, single-use 250 µL custom marked syringe from the packaging. 
• Attach a 19-gauge x 1½-inch filter needle to the syringe. RBM-007 is dispensed in a 0.5 
mL fill in a 2 mL vial.  
• Using sterile technique, carefully draw up approximately 200 µL of RBM-007 into the 
syringe. (Sufficiently larger volume than 50 or 100 µL is needed to allow for dead 
space in syringe and needles prior to i.vt. injection). 
• Remove the 19-gauge x 1½-inch filter needle from the syringe and replace with a 30-
gauge x 0.5-inch needle for the i.vt. injection. 
• Ensure that the 30-gauge x 0.5-inch needle is affixed tightly to the syringe. 
• Align the top edge of the red O-ring of the plunger with appropriate mark on the 
syringe, expelling the excess fluid drawn up.  
• Ensure there are no air bubbles within the syringe or the needle hub prior to injection, 
and prior to expelling the excess fluid drawn up 
7.6 
Eye Preparation 
Prior to RBM-007 administration, the study eye should be prepared as follows: 
• Dilate pupil (1% tropicamide and 2.5% phenylephrine or equivalent applied topically) 
approximately 10 minutes prior to injection. 
• Administer 1 drop of topical anesthetic (0.5% proparacaine hydrochloride ophthalmic 
solution or an equivalent topical ophthalmic anesthetic). 
• Take 2 sterile cotton tipped applicators and thoroughly soak with 0.5% proparacaine 
topical anesthetic eye drops or an equivalent topical ophthalmic anesthetic. Place the 
soaked applicators, side by side, gently but firmly on the conjunctival surface at the area 
of the entry site described below in Step 2 (Section 7.7) and hold in place for 
approximately 1 minute. 
• Insert sterile eyelid speculum. 
• Administer 5% povidone iodine flush over the ocular surface and lids. 
7.7 
Study Drug Administration 
• Prior to starting the injection procedure, RBM-007 should have been prepared as 
described in Section 7.4 and Section 7.5, and the study eye should have been prepared 
as described in Section 7.6. 
• The entry site for injection is 4.0 mm posterior to the corneal limbus. A caliper may be 
used to identify the needle entry site. 
• Insert the needle perpendicular to the eye wall at the location specified in Step 2 
(Section 7.7) to inject the study solution into the vitreous cavity. Note: If paracentesis is 
considered necessary, it should be performed prior to injection of the RBM-007 and 
noted in the source documents. 

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• Very slowly, inject the entire RBM-007 dose volume (50 µL or 100 µL) and slowly 
withdraw the needle. Do not pull back on the plunger at any time prior to withdrawing 
the needle. 
• Briefly apply pressure for approximately 30 seconds to the needle entry site with sterile 
cotton tipped applicator (may be skipped per Clinical Investigator's discretion). 
• Remove the eyelid speculum and rinse the eye with sterile eye wash solution. 
• Patch the study eye at the Clinical Investigator's discretion. 
• Prescribe fluoroquinolone equivalent antibiotic eye drops three times/day for two days 
following injection, to be initiated as soon as possible. 
7.8 
Study Drug Accountability 
The Principal Investigator is responsible for ensuring that an inventory is conducted upon 
receipt of the clinical supplies. The temperature recorder from the shipment will be 
deactivated and authorized study staff will verify that the temperature was maintained at -
20°C during transit. The clinical supplies shipment form should be completed, signed, and 
returned as directed. A copy must be maintained at the site for the Principal Investigator's 
records. 
The Principal Investigator will keep a current record of the inventory, storage conditions 
and dispensing of all study drugs. This record will be made available to RIBOMIC (or 
designee) for accounting for all clinical supplies. Any significant discrepancy and/or 
deficiency must be recorded with an explanation. 
All supplies sent to the Principal Investigator must be accounted for and in no case will 
study drugs be used in any unauthorized situation. It is the responsibility of the Principal 
Investigator to ensure that any used and unused supplies are available to RIBOMIC (or 
designee) throughout the study. 
7.9 
Study Drug Handling and Disposal 
All investigational products including unused vials of RBM-007 supplied by 
RIBOMIC/Representative will be fully accounted for by the monitor with the help of the 
person responsible for dispensing the RBM-007 and will be returned to 
RIBOMIC/Representative or designee. Accountability will be documented by use of drug 
accountability forms.  
The used vials of RBM-007 will be stored at the investigational site upon completion of 
accountability procedures and returned to RIBOMIC or designee after the trial is 
completed. 
8 ASSESSMENT OF SAFETY 
8.1 
Adverse Events 
8.1.1 Definition of Adverse Events 
An AE is any untoward medical occurrence in a subject administered a pharmaceutical 
product and does not necessarily have a causal relationship with RBM-007. An AE, 
therefore, can be an unintended sign (including an abnormal laboratory finding), symptom, 
or disease that has clinical significance and is temporally associated with the use of a 

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medicinal (investigational) product, whether related or not related to the medicinal 
(investigational) product. 
In clinical studies, an undesirable medical condition occurring at any time, including-
baseline or pre-treatment period, may be recorded as an AE even if no RBM-007 has been 
administered. 
Any significant adverse change in a subject's condition from baseline, regardless of 
causality, is to be considered an AE, unless the change is determined to be a continuation of 
a pre-existing condition that is documented in the subject's medical history. However, a 
clinically significant worsening in severity, intensity, or frequency of a pre-existing 
condition may indicate an AE. In addition, all conditions that lead to hospitalizations, 
defined as an overnight hospital stay, are considered as AEs. This includes planned elective 
surgeries. 
Lack of efficacy of the i.vt. RBM-007 for the condition being investigated is not considered 
an AE unless a clinically significant change is assessed by the Clinical Investigator. An 
elective surgical procedure scheduled or planned prior to study entry is not considered an 
AE if an overnight hospital stay is not required, and the underlying diagnosis for which 
surgery is to be performed should be captured in the medical history as a pre-existing 
condition. The surgical procedure should also include the term "elective" in all reports. 
8.1.1.1 Assessment of Adverse Events 
Clinical Investigators will seek information on AEs at each subject contact. Subjects should 
be asked, using a general, non-direct question, if there has been any change in their general 
health. Direct questioning and examination should then be performed as appropriate. 
Severity of the AE should be assessed according to the following criteria: 
Mild: No interference with the subject's daily activities; no medical intervention/therapy 
required 
Moderate: Possible interference with the subject's daily activities; no or minimal medical 
intervention/therapy required 
Severe: Considerable interference with the subject's daily activities; medical 
intervention/therapy required 
Regardless of severity, some AEs may also meet regulatory serious criteria refer to 
definitions and reporting of serious adverse events (SAEs) in Section 8.1.2. 
A Clinical Investigator who is qualified in medicine must make the determination of the 
relationship of the investigational drug, RBM-007 to each AE (related or not related). The 
Clinical Investigator should decide whether, in his or her medical judgment, there is a 
reasonable possibility that the RBM-007 caused the AE/SAE based on facts, evidence, 
scientific rationales, and clinical judgment. When assessing causality, the Clinical 
Investigator may consider the following information when determining the relationship to 
the RBM-007 for each AE: mechanism of action, biologic plausibility, confounding risk 
factors (i.e., medical history, concomitant medications), temporal relationship, 
dechallenge/rechallenge, and lack of alternative explanation. It should be specified if the 
AE is related to the injection procedure and not the study drug. 
• Not Related: The event is clearly related to other factors such as subject’s clinical 
condition, therapeutic interventions, concomitant disease or therapy administered to 
the subject and does not follow a known response pattern to the product. 

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• Possibly Related: The event follows a reasonable, temporal sequence from the 
time of study medication administration and/or follows a known response 
pattern to the study medication, but could have been produced by other factors such 
as the subject’s clinical state, therapeutic interventions or concomitant therapy 
administered to the subject. 
• Related: The event follows a reasonable, temporal sequence from the time of 
study medication administration and/or follows a known response pattern to the 
study medication and cannot be reasonably explained by other factors such as 
subject’s clinical state, therapeutic interventions or concomitant therapy administered 
to the subject, and either occurs immediately following study medication 
administration, or improves on stopping the study medication, or reappears on repeat 
exposure, or there is a positive reaction at the application site. 
8.1.1.2 Reporting Adverse Events 
AEs, whether spontaneously reported by the subject or noted by authorized study 
personnel, will be recorded in the subject's medical record and on the appropriate AE CRF. 
Each recorded AE will be described by its duration (i.e., start and end dates), severity, 
regulatory seriousness criteria if applicable, suspected relationship to the RBM-007, actions 
taken and outcome. 
AEs that occur after any subject has provided written informed consent, before treatment, 
during treatment, or within 30 days following the cessation of treatment, whether they are 
related to the study, must be recorded. To improve the quality and precision of acquired AE 
data, Clinical Investigators should observe the following guidelines: 
1. Whenever possible, use recognized medical terms when recording. Do not use 
colloquialisms and/or abbreviations. 
2. If known, record the diagnosis (i.e., disease or syndrome) rather than component signs 
and symptoms and /or laboratory or test findings (e.g., record congestive heart failure 
rather than dyspnea, rales, and cyanosis, and enlarged heart on chest x-ray). However, 
other events that are considered unrelated to an encountered syndrome or disease should 
be recorded as individual AEs (e.g., if congestive heart failure and severe headache are 
observed at the same time and are clinically unrelated, each event should be recorded as 
an individual AE). 
3. If the diagnosis is not known, then record the leading component sign, symptom or test 
finding and describe the other clinically related findings in the narrative description of 
the case. A suspected diagnosis can be used and described as such (e.g., record 
suspected or probable myocardial infarction); this has to be updated in the clinical 
database once the diagnosis is confirmed. AEs occurring secondary to other events (e.g., 
sequelae) should be identified by the primary cause. A primary AE, if clearly 
identifiable, generally represents the most accurate clinical term. If a primary AE is 
recorded, events occurring secondary to the primary event should be described in the 
narrative description of the case. For example:  
a. The subject developed orthostatic hypotension and subsequently fainted and 
fell to the floor wherein she experienced a head trauma and neck pain. 
b. The primary AE in this example is orthostatic hypotension. The fall, head 
trauma and neck pain should be described in the narrative description of the 
case. 
4. For intermittent events (e.g., intermittent headache), the event onset date should be 
recorded as the date the subject first started to experience the event and resolution date 
should reflect when the last occurrence resolved or stopped. Separate AEs for each 
event should not be recorded. For example, if a subject experienced headache on 

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14SEP2017 lasting for three hours, then subsequently experienced intermittent episodes 
of headache every day for approximately 3 hours until 21SEP2017, then the AE date of 
onset is 14SEP2017 and the resolution date is 21SEP2017. 
5. For intermittent events, record the maximum severity of the individual events. For 
example, if a subject complains of intermittent headaches for one week and the severity 
of each headache ranges from mild to moderate, then the severity would be moderate. 
6. For intermittent hospitalizations occurring for a primary AE (e.g., in a subject with 
multiple sclerosis, commonly known for its relapsing and remitting course, in some 
cases leading to multiple hospital confinements), the subsequent hospitalizations should 
be described in the narrative description of the case. 
7. If treatment was initiated, include the treatment and duration of the medication(s) in the 
CRF. 
8.1.2 Serious Adverse Events 
SAEs are defined as any findings that suggest a significant hazard, contraindication, side 
effect, or precaution. Any adverse event is considered a serious adverse event if it results in 
any of the following outcomes: 
1. Death 
2. Life threatening event: 
A life-threatening event is any event that places the subject at immediate risk of death 
from the event as it occurred; it does not refer to an event that hypothetically might 
have caused death if it were more severe. 
3. Hospitalization, at the minimum an overnight stay 
4. A persistent or significant disability/incapacity 
5. A congenital anomaly/birth defect 
6. Other medically significant events: 
 
Other medically significant events are events that may not result in death, be life-
threatening, or require hospitalization but may be considered a serious adverse drug 
experience when, based upon appropriate medical judgment, they may jeopardize the 
subject and may require medical or surgical intervention to prevent one of the outcomes 
listed above. 
7. Sight threatening event: 
A sight-threatening event is any event that places the subject at immediate risk of 
permanently losing vision in either eye as a direct result of the event. 
8.1.2.1 Reporting Serious Adverse Events 
A SAE CRFmust be completed with as much information available within 24 hours of 
knowledge of the event. 
To improve the quality and precision of acquired SAE data, Clinical Investigators should 
observe the following guidelines: 
• Death - Death is an outcome of an event. The event that resulted in the death should be 
recorded and reported as a SAE. 
• Hospitalizations for Surgical or Diagnostic Procedures - The illness leading to the 
surgical or diagnostic procedure should be recorded as the SAE, not the procedure 
itself. The procedure should be captured in the case narrative as part of the action taken 
in response to the illness. 

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When new significant information (including the outcome of the event) is obtained, the 
Clinical Investigator should enter the information directly into the CRF within 24 hours or 
as soon as possible after knowledge of the information. 
Depending on the nature and seriousness of the AE, RIBOMIC may request additional 
documentation, for example, copies of the ophthalmic and medical record of the subject as 
well as results of laboratory tests. If the subject was hospitalized, the site should summarize 
the hospital discharge summary and provide to RIBOMIC upon request. 
8.1.2.2 Expedited Reporting of Serious Adverse Events 
RIBOMIC (or designee) will provide the Principal Investigator with a reporting cover letter 
and an anonymized MedWatch 3500A for expedited reporting of SAEs to the IRB or 
Independent Ethics Committee (IEC). The Principal Investigator is responsible for 
receiving and reviewing expedited safety reports, submitting expedited safety reports to the 
IRB or IEC, and maintaining copies of expedited safety reports in the study records. 
8.1.3 Events of Special Interest 
Events of Special Interest (ESIs) are events that may require special attention for the 
purposes of on-going patient safety review during this study. The following are considered 
ESIs and should be reported on the appropriate CRF with as much information as available 
within 24 hours of knowledge of the event: 
• Study medication administration error - Study medication administration errors 
determined to be significant by the Clinical Investigator will be reported and evaluated 
as ESIs. Examples of study medication administration errors may include but are not 
limited to: overdose of study medication and administration of study medication from 
an incorrect kit. 
• Pregnancy - There are no controlled data with the investigational product in human 
pregnancy. It is required that women of childbearing potential use effective 
contraception during the study and recommended for 12 weeks after the completion of 
the study. Any pregnancy occurring during study treatment should be reported and the 
subject removed from the study. The subject should be followed until the end of 
pregnancy or until the end of the study, whichever is longer. 
8.1.4 Follow-up of Adverse Events 
All reported AEs at study exit will be followed by the Clinical Investigator (or his/her 
designee) until the event is resolved or determined to be irreversible, chronic, or stable. 
In addition, on a case-by-case basis, RIBOMIC (or designee) may request follow up 
beyond the end of the study. 
If RIBOMIC requests follow-up on an individual SAE or designated SAE, site response to 
follow-up requests should be e-mailed to yusuf.ali@ribomic.com. 
8.1.5 Manual Back-Up Reporting Procedures 
This study may utilize an electronic data capture (EDC) system for data collection. In the 
event that an EDC system is utilized, but unavailable for electronic reporting, the manual 
back-up reporting procedures below should be followed. 
• Complete an AE and SAE form. 
• Email the AE and SAE form to RIBOMIC at yusuf.ali@ribomic.com.  

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When the EDC system becomes available, update the EDC system with all previously 
reported information. 
8.2 
Safety Parameters 
The safety assessments will include adverse events (AEs), BCVA, slit-lamp exam and 
biomicroscopy, indirect ophthalmoscopy, intraocular pressure (TOP), serum chemistry, 
hematology, vital signs, physical exam, fundus photography, fluorescein angiography, 
EKG, pregnancy. 
8.2.1 Physical Examination 
A full body systematic physical exam will be conducted by the Clinical Investigator or an 
external internist during Screening Visit and Visit Day 56 (±3). 
8.2.2 Electrocardiogram (EKG) 
EKG will be performed at Screening Visit. The Clinical Investigator will review the EKG 
report for abnormalities. 
8.2.3 Vital Signs 
Blood pressure and heart rate will be measured at each visit using an automated or manual 
blood pressure monitor. Systolic and diastolic blood pressures will be recorded in 
millimeters of mercury (mmHg), and heart rate will be recorded in beats per minute (bpm). 
8.2.4 Best Corrected Visual Acuity 
The BCVA will be recorded using the ETDRS chart and total number of letters at 4 meters 
and 1 meter will be recorded at each visit. If a subject could not read ETDRS chart, Finger 
Counts, Hand Motion, Light Perception, or No Light Perception will be recorded. 
8.2.5 Slit-lamp exam and Biomicroscopy 
Slit-lamp exam and biomicroscopy will be performed at each visit. At the Baseline Visit 
(Day 0), a biomicroscopy examination will be performed prior to RBM-007, and a second 
biomicroscopy exam will be performed within 30 minutes after injection. 
8.2.6 Intraocular Pressure 
IOP will be measured by applanation tonometry and reported in millimeters of mercury 
(mmHg) at each study visit. On the visit for RBM-007 injection or any anti-VEGF 
injections, IOP will be measured before RBM-007 or anti-VEGF injection and 30 (±10) 
minutes after injection. If post-injection IOP is increased ≥ 10 mmHg from pre-injection 
IOP, the IOP will be measured again 60 (±10) minutes following injection. If there is an 
increase of ≥ 10 mmHg at 60 (±10) minutes post-injection compared to pre-injection IOP, 
the subject will be prescribed a topical IOP-lowering medication until he or she returns for 
follow-up per the Clinical Investigator's discretion (an unscheduled visit may apply), and 
the IOP increase of ≥ 10 mmHg shall be reported as an AE. 

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8.2.7 Indirect Ophthalmoscopy 
Indirect ophthalmoscopy will be performed at each visit. On the visit of RBM-007 or anti-
VEGF injection, an ophthalmoscopy examination will be performed prior to RBM-007 or 
anti-VEGF injection and a second one within 30 minutes after injection. 
8.2.8 Serum Pregnancy Test 
A serum pregnancy test will be conducted at Screening Visit for all women of childbearing 
potential. 
8.2.9 Serum Chemistry, Hematology 
Patients will be sent for laboratory tests at Screening Visit and Visit Day 28 (±2). 
8.2.10 Fundus Photography 
Digital color fundus photography will be taken at Baseline Visit (Day 0), Visit Day 28 (±2), 
and Visit Day 56 (±3) in both eyes. It will be performed prior to any intravitreal injections. 
Required fields to be captured are: 1) Nasal to macula (the image is centered on the optic 
nerve), 2) Posterior pole (the image is centered on the macula). 
8.2.11 Fluorescein Angiography 
Fundus fluorescein angiography will be taken at Baseline Visit (Day 0), Visit Day 28 (±2), 
and Visit Day 56 (±3) in both eyes, with early studies in the study eye. It will be performed 
prior to any intravitreal injections. Required fields to be captured are: Nasal to macula (the 
image is centered on the optic nerve), Posterior pole (the image is centered on the macula). 
8.2.12 OCT-Angiography 
OCT-angiography will be taken at Baseline Visit (Day 0), Visit Day 28, and Visit Day 56 in 
both eyes. It will be performed prior to any intravitreal injections. 
8.2.13 Adverse Events 
AEs will be elicited from the subjects starting at every visit from Baseline Visit (Day 0) 
through Visit Day 56. The information will include at least a description of the event, 
whether it is serious, onset and duration, frequency, severity, relation to RBM-007, relation 
to injection procedure, location (OD, OS, OU or NA), action taken and outcome. Prior to 
evaluating the incidences, all AEs will be coded using the Medical Dictionary for 
Regulatory Activities (MedDRA, 2013). Ocular and non-ocular AEs will be summarized 
separately. See Section 8.1 for complete information regarding AE reporting. 
9 ASSESSMENT OF BIOACTIVITY 
Bioactivity will be assess by both structural and functional measures. 
Resolution of subretinal fluid will be assessed using the change in CST and the macular 
volume based on SD-OCT. SD-OCT will be performed for both eyes at each visit. CST, an 
average of central subfield thickness, will be recorded. In addition, macular volume will be 
determined. Assessment of CNV size and activity will be measured with fundus 
photography, fluorescein angiography, and OCT-angiography at Baseline Visit (Day 0), 
Visit Day 28 endpoint, and Visit Day 56 exit. 

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Functional changes in vision will be assessed by best corrected visual acuity, measured 
using ETDRS eye charts.  
10 OTHER ASSESSMENTS 
10.1 Demographics and Baseline Characteristics 
Subject demographics include age, race, sex, and ethnicity. Baseline characteristics include 
medical history, prior medications, and baseline results of physical exam, EKG, heart rate 
and blood pressure, BCVA, slit-lamp exam and biomicroscopy, IOP, indirect 
ophthalmoscopy, SD-OCT, pregnancy test, laboratory tests (hematology, serum chemistry), 
fundus photography, fluorescein angiography, and OCT-angiography. For assessments 
performed multiple times before the injection of i.vt. RBM-007, the last pre-injection value 
will be used as the baseline value. 
10.2 Other Assessments 
Other assessments include concomitant medications and exposure to study drug. 
11 STATISTICAL METHODS 
11.1 General Considerations 
All study parameters will be listed, and a selected list of parameters will be summarized 
descriptively by dose level and overall. The descriptive statistics will include number of 
observations (n), mean, standard deviation, minimum, and maximum for continuous 
parameter and frequency (n) and percent (%) for categorical parameters. 
Details about the statistical analyses for this study will be provided in the statistical analysis 
plan (SAP). 
11.1.1 Study Endpoints  
Safety: 
• Incidence and severity of adverse events (AEs), slit-lamp exam and biomicroscopy, 
indirect ophthalmoscopy, BCVA, IOP, SD-OCT, fundus photography, fluorescein 
angiography, serum chemistry, hematology, heart rate and blood pressure, physical 
exam, EKG and pregnancy 
Bioactivity: 
• Change in CST and macular volume based on SD-OCT at each visit post RBM-007 
treatment. 
• Change in CNV lesion size and activity based on fundus photography, fluorescein 
angiography, and OCT-angiography. 
• Change from baseline in BCVA 
11.1.2 Sample Size 
Approximately nine subjects (3 subjects per cohort) with exudative age-related macular 
degeneration will be enrolled at 4-5 sites. The final number of subjects enrolled may be 

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adjusted based on the presence of dose limiting toxicities. This sample size is not planned 
based on statistical considerations. 
11.1.3 Statistical Hypotheses and Level of Significance  
No statistical hypothesis is defined for this study. 
11.1.4 Randomization 
This is an open-label, non-randomized study. 
11.1.5 Study Eye 
The study eye is defined as the eye with worse vision. If both eyes have the same vision, 
the right eye (OD) should be determined as the study eye. 
11.2 Study Populations 
The following study populations are defined for analysis: Intention-to-treat (ITT) and 
Safety. 
ITT Population: The ITT population will include all subjects in the study. It will be the 
primary study population for bioactivity analyses, where subjects are grouped by planned 
dose level unless specified otherwise. 
Safety Population: The Safety population will include all subjects who receive the 
injection of i.vt. RBM-007. It will be the study population for safety analyses performed 
with subjects as treated. 
11.3 Handling of Missing Values 
For safety measures, missing scores will not be imputed for data summaries. 
Completely or partially missing onset and resolution dates for AEs and completely or 
partially missing start and end dates of concomitant medications will be imputed in a 
conservative fashion that will be detailed in the SAP. 
For Bioactivity endpoints, missing post-injection values will be imputed using the last- 
observation-carried-forward (LOCF) approach. 
11.4 Demographics and Baseline Characteristics 
Age, sex, race, ethnicity, and baseline assessments will be summarized descriptively by 
dose level. 
Subjects with abnormal medical history will be tabulated by treatment arm and body 
system. 
Subjects using any prior medications will be tabulated by dose level, Anatomical 
Therapeutic Chemical levels, and preferred term specified in the World Health Organization 
Drug Dictionary Enhanced (World Health Organization Drug Dictionary Enhanced, 2011) 
11.5 Bioactivity Analyses 
Changes from baseline in BCVA, retinal thickness (CST), and macular volume will be 
summarized descriptively by dose level of RBM-007. CNV size and activity will be 
summarized from fundus photography, fluorescein angiography, and OCT-angiography. 

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11.6 Safety Analysis 
All safety outcome measures will be summarized descriptively for the Safety Population. 
The safety outcome measures include adverse events (AEs), BCVA, slit-lamp exam and 
biomicroscopy, indirect ophthalmoscopy, intraocular pressure (IOP), serum chemistry, 
hematology, heart rate and blood pressure, physical exam, fundus photography, fluorescein 
angiography, EKG and pregnancy test. 
AEs will be coded using the Medical Dictionary for Regulatory Activities (MedDRA).   
Subjects with any AEs will be tabulated by system organ classification and preferred term 
specified in the MedDRA. Similarly, subjects with any ocular and non-ocular AEs and ESIs 
will be tabulated separately. AEs, ocular and non-ocular, as well as SAE will also be 
summarized by relationship to treatment and maximum severity. In addition, SAEs and 
discontinuations due to AEs will be summarized. 
Ocular safety outcome measures will be summarized using descriptive statistics. 
12 DIRECT ACCESS TO SOURCE DATA/DOCUMENTS 
The Principal Investigator will allow representatives of RIBOMIC’s monitoring team (or 
designee), the governing institutional review board (IRB), the FDA, and other applicable 
regulatory agencies to inspect all study records, CRF, recruitment materials and 
corresponding portions of the subject's medical records at regular intervals throughout the 
study. These inspections are for verifying adherence to the protocol, completeness, and 
exactness of the data being entered onto the CRF, and compliance with the FDA or other 
regulatory agency regulations. 
12.1 Study Monitoring 
Before an investigational site can enter a subject into the study, a representative of 
RIBOMIC (or designee) will evaluate the investigational study site to: 
• Determine the adequacy of the study facilities. 
• Review with the Principal Investigator(s) and authorized study staff their 
responsibilities regarding protocol procedures adherence, and the responsibilities of 
RIBOMIC (or designee). 
• During the study, RIBOMIC (or designee) will have regular contact with the 
investigational site, for the following: 
• Provide information and support to the Principal Investigator(s). 
• Confirm that facilities remain acceptable. 
• Assess adherence to the protocol and GCP. 
• Perform investigational product accountability checks and quality control 
procedures. 
• Ensure the on-going implementation of accurate data entry in the CRF. 
• Perform source data verification, including a comparison of the data in the CRFs 
with the subject's medical records and other records relevant to the study. This will 
require direct access to all original records for each subject (e.g., clinic charts). 
• Record and report any protocol deviations not previously sent to RIBOMIC (or 
designee). 

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• Confirm AEs and SAEs have been properly documented on CRFs and confirm any 
SAEs have been forwarded to RIBOMIC and those SAEs that met criteria for 
reporting have been forwarded to the IRB or Independent Ethics Committee (IEC). 
RIBOMIC (or designee) may remotely access the CRFs, as applicable, at any time during 
the study for centralized monitoring. RIBOMIC (or designee) will be available between 
visits if authorized study staff needs study related information or support. 
12.2 Audits and Inspections 
The Principal Investigator will allow RIBOMIC (or designee), the governing IRB or IEC, 
and applicable regulatory agencies to audit and inspect any aspect of the study, including all 
study records, CRFs, recruitment materials, and corresponding portions of the subject's 
charts and medical records at any time during the study. These study records must be 
retained at the study site and made available for audits and inspections. The purpose of 
these audits and inspections is to verify adherence to the protocol, completeness and 
accuracy of the CRF data, and compliance with Good Clinical Practice (GCP) guidelines 
and applicable regulatory requirements. 
The Principal Investigator or authorized study staff will notify RIBOMIC (or designee) 
should the site be audited or inspected by the governing IRB or IEC, and applicable 
regulatory agencies. RIBOMIC (or designee) will also notify the investigational site of any 
known pending site audits or inspections planned by RIBOMIC (or designee), governing 
IRB or IEC and regulatory agencies. 
12.3 Institutional Review Board 
The Principal Investigator must obtain IRB approval for the investigation. Initial IRB 
approval, and all materials approved by the IRB for this study including the subject consent 
form and recruitment materials must be maintained by the Principal Investigator and made 
available for inspection. 
13 QUALITY CONTROL AND QUALITY ASSURANCE 
13.1 Quality Control 
RIBOMIC (or designee) will provide instructional material to the study sites, as 
appropriate; including but not limited to instruction on the protocol, the completion of 
CRFs, and study procedures. RIBOMIC (or designee) will communicate regularly with site 
personnel via mail, email, telephone, and/or fax; and make periodic visits to the study site. 
During those visits, RIBOMIC (or designee) will perform source data verification with the 
subject's medical records and other records relevant to the study. Upon receiving the CRFs, 
as applicable, RIBOMIC (or designee) will review and evaluate CRF data and use standard 
system edits and may use centralized monitoring to detect errors in data collection. 
13.2 Quality Assurance 
RIBOMIC (or designee) may conduct a quality assurance audit at any time. 

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14 ETHICS 
14.1 Ethics Review 
The final study protocol and the final version of the ICF, and other study related material, 
as appropriate, must be approved or given a favorable opinion in writing by an IRB or IEC 
as appropriate. The Principal Investigator must submit written approval to RIBOMIC (or 
designee) before study initiation. See Appendix 1 for a list of obligations of Investigators. 
The Principal Investigator is responsible for informing the IRB or IEC of any amendment 
to the protocol in accordance with local regulations and guidelines. In addition, the IRB or 
IEC must approve all advertising used to recruit subjects for the study. The protocol must 
be re-approved by the IRB or IEC upon receipt of amendments and at least annually. 
The Principal Investigator is also responsible for providing the IRB or IEC with progress 
reports and notifications of any reportable SAEs attributable to the investigational product. 
14.2 Ethical Conduct of the Study 
This study will be conducted in compliance with IRB or IEC, and regulatory requirements. 
This study will also be conducted in compliance with the protocol, GCP guidelines, 
International Conference on Harmonization (ICH) guidelines, the Declaration of Helsinki, 
and Health Insurance Portability and Accountability Act of 1996 (HIPAA). 
14.3 Written Informed Consent 
The Principal Investigator at each center will ensure that the subject is given full and 
adequate oral and written information about the nature, purpose, possible risk and possible 
benefit of the study. Subjects must also be notified that they are free to withdraw from the 
study at any time. Subjects should be given the opportunity to ask questions and allowed 
time to consider the information provided. Before participating in any study-related activity, 
voluntary informed consent must be documented by the use of a written ICF approved by 
the IRE or IEC and signed and dated by the subject or the subject's legally authorized 
representative at the time of consent. The original signed and dated ICF will be retained 
with the study records, and a copy of the signed ICF will be given to the subject or the 
subject's legally authorized representative. 
15 DATA HANDLING AND RECORDKEEPING 
15.1 Inspection of Records 
The Principal Investigator will allow RIBOMIC (or designee), the governing IRB or IEC 
and applicable regulatory agencies to inspect any aspect of the study, including all study 
records, CRFs, recruitment materials and corresponding portions of the subject's charts and 
medical records at any time during the study. The purpose of these inspections is to verify 
adherence to the protocol, completeness and accuracy of the CRF data, and compliance 
with GCP guidelines and applicable regulatory requirements. 
15.2 Retention of Records 
All records relating to the conduct of this study are to be retained by the Principal 
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15.2.1 Source Documents 
The Principal Investigator must maintain detailed source documents on all study subjects 
who provide informed consent. Source documents include subject medical records, hospital 
charts, study files, as well as the results of diagnostic tests (e.g., laboratory tests). 
The following minimum information should be entered into the subject's medical record: 
• The date the subject was enrolled and the subject number 
• The study protocol number and the name of RIBOMIC. 
• The date that informed consent was obtained 
• Evidence that the subject meets study eligibility requirements (e.g., medical history, 
study procedures and/or evaluations) 
• The dates of all study-related subject visits 
• Evidence that required procedures and/or evaluations were completed 
• Use of any concomitant medications 
• Documentation of study drug accountability 
• Occurrence and status of any AEs 
• The date the subject exited the study and a notation as to whether the subject completed 
or terminated early from the study, including the reason for early termination. 
15.2.2 Data Collection 
The Principal Investigator must maintain detailed records on all subjects who provide 
informed consent. Data for screened and enrolled subjects will be entered in CRFs. Review 
of the CRFs will be completed remotely by RIBOMIC (or designee). At designated 
intervals, a study monitor will perform source data verification on site.  During those 
visits, RIBOMIC (or designee) will monitor the subject data recorded in the CRF against 
source documents at the study site. 
RIBOMIC (or designee) will review and evaluate CRF data and use standard system edits, 
and may use centralized monitoring evaluations, to detect errors in data collection. At the 
end of the study, a copy of the completed CRFs will be sent to the site to be maintained as 
study records. 
16 PUBLICATION POLICY 
The existence of this clinical study is confidential, and it should not be discussed with 
persons outside of the study. Additionally, the information in this document and regarding 
this study contains trade secrets and commercially sensitive information that is confidential 
and may not be disclosed unless such disclosure is required by federal or state law or 
regulations. Subject to the foregoing, this information may be disclosed only to those 
persons involved in the study who have a need to know, but all such persons must be 
instructed not to further disseminate this information to others. These restrictions of 
disclosure will apply equally to all future information supplied that is indicated as 
confidential Information pertaining to this study will be published on 
www.clinicaltrials.gov as required by the Food and Drug Administration (FDA). 
The data generated by this clinical study are the property of RIBOMIC and should not be 
disclosed without the prior written permission of RIBOMIC. These data may be used by 

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RIBOMIC now and in the future for presentation or publication at RIBOMIC’s discretion 
or for submission to governmental regulatory agencies. RIBOMIC reserves the right of 
prior review of any publication or presentation of data from this study. 
In signing this protocol, the Principal Investigator agrees to the release of the data from this 
study and acknowledges the above publication policy. 
17 REFERENCES 
Atsumi I, Kurata M, Sakaki H. Comparative study on ocular anatomical features among 
rabbits, beagle dogs and cynomolgus monkeys. Anim. Animal Eye Res 2013;32:35–41 
Belgore F, Lip GYH, Blann AD. Basic fibroblast growth factor induces the secretion of 
vascular endothelial growth factor by human aortic smooth muscle cells but not by 
endothelial cells. European Journal of Clinical Investigation 2003; 33:833-839. 
Bikfalvi A, Klein S, Pintucci G, Rifkin DB. Biological roles of fibroblast growth factor-2. 
Endocr Rev 1997;18(1):26-45. 
Brown DM, Kaiser PK, Michels M, et al. ANCHOR Study Group: ranibizumab versus 
verteporfin for neovascular age-related macular degeneration. New England Journal of 
Medicine 2006; 355:1432-44. 
Chew EY, Clemons T, Sangiovanni JP, et al. The Age-related Eye Disease Study 2 
(AREDS2): Study Design and Baseline Characteristics (AREDS2 Report Number 1). 
Ophthalmology 2012; 119:2282-89. 
Ferris FL, III, Fine SL, Hyman L. Age-related macular degeneration and blindness due to 
neovascular maculopathy. Arch. Ophthalmol 1984;102(11):1640-42. 
Friedman DS, O'Colmain BJ, Munoz B, et al. Prevalence of age-related macular 
degeneration in the United States. Arch Ophthalmol 2004;122(4):564-72. 
Heier JS, Brown DM, Chong V, et al. VIEW 1 and VIEW 2 Study Groups: Intravitreal 
aflibercept (VEGF trap-eye) in wet age-related macular degeneration. Ophthalmology 
2012; 119: 2537-48. 
Jabs DA, Nussenblatt RB, Rosenbaum JT. Standardization of uveitis nomenclature for 
reporting clinical data. Results of the First International Workshop. Am J Ophthalmol 2005; 
140:509-16 
Jin L, Nonaka Y, Miyakawa S, Fujiwara M, Nakamura Y. Dual Therapeutic Action of a 
Neutralizing Anti-FGF2 Aptamer in Bone Disease and Bone Cancer Pain. Mol Ther 2016; 
24:1974-86.  
Maguire MG, Martin DF, Ying GS, et al. CATT Research Group. Five-year outcomes with 
anti-vascular endothelial growth factor treatment of neovascular age-related macular 
degeneration: The Comparison of Age-Related Macular Degeneration Treatments Trials. 
Ophthalmology 2016; 123:1751-61. 
Martin DF, Maguire MG, Fine SL et al. Comparison of Age-Related Macular Degeneration 
Treatments Trials (CATT) Research Group. Ranibizumab and bevacizumab for treatment of 
neovascular age-related macular degeneration: 2-year results. Ophthalmology 2012; 
119:1388-8. 
Nussenblatt RB, Palestine AG, Chan CC, Roberge F. Standardization of vitreal 
inflammatory activity in intermediate and posterior uveitis. Ophthalmology 1985; 92:467-
71. 

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Panda-Jonas S, Jonas JB, Jakobczyk M, Schneider U. Retinal photoreceptor count, retinal 
surface area, and optic disc size in normal human eyes. Ophthalmology 1994; 101:519-23. 
Rofagha S, Bhisitkul RB, Boyer DS, et al. Seven-year outcomes in ranibizumab-treated 
patients in ANCHOR, MARINA, and HORIZON a multicenter cohort study (SEVEN-UP). 
Ophthalmology 2013; 120:2292-99 
Schultz GS and Grant AB. Neovascular growth factors. Eye 1991; 1:70-80. 
Sherwood M, Brandt J. Six-month comparison of bimatoprost once-daily and twice-daily 
with timolol twice-daily in patients with elevated intraocular pressure. Surv Ophthalmol 
2001;45(6 Suppl 2):S361-S68. 
Strutz F, Zeisberg M, Ziyadeh FN, et al. Role of basic fibroblast growth factor-2 in 
epithelial-mesenchymal transformation. Kidney Int 2002; 61:1714–28. 
Vinding T. Occurrence of drusen, pigmentary changes and exudative changes in the macula 
with reference to age-related macular degeneration. An epidemiological study of 1000 aged 
individuals. Acta Ophthalmologica 1990; 68:410–14. 
 
 
 

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Appendix 1: Obligations of Investigators 
In summary, the Clinical Investigator has agreed to the following obligations: 
• Obtaining informed consent from every subject prior to the subject's participation in any 
study related activity and maintaining records of consent as part of the study records. 
• Obtaining approval from the IRB before involving any subject in any study related 
activity; submitting verification of the approval to the Sponsor; submitting periodic 
progress reports (at least annually) and final report to IRB and to the Sponsor. 
• Approving the protocol and conducting the study according to the protocol and 
applicable regulations; informing the Sponsor of all deviations from the protocol. 
• Informing the IRB of all protocol amendments/modifications; sending the Sponsor a 
copy of the letter from the IRB approving the amendment/modification. 
• Reporting to the Sponsor and the IRB any adverse experiences that occur in the course 
of the investigation, this includes Serious Adverse Events within 24 hours. 
• Keeping careful and accurate records of all clinical study data (study records must be 
considerably more exact and complete than those kept in ordinary medical practice); 
maintaining records of all materials submitted to the IRB and of all action by the IRB 
regarding the study. 
• Making study records available for inspection by the Sponsor and representatives of the 
Food and Drug Administration and other regulatory agencies; keeping records until 
notified by the Sponsor that they may be destroyed. 
• Maintaining proper control and documentation of all test and control articles, where 
applicable. 
• Submitting the following records and reporting to the Sponsor. 
 
I. Prior to the Beginning of the Study 
• A signed Form FDA-1572, Statement of Investigator. 
• A current curriculum vitae (CV) if not submitted to RIBOMIC previously or if updated. 
• CVs for all sub-Investigators listed on the 1572. 
• A letter from the IRB indicating that the protocol was approved, including the name and 
address of the IRB. 
• A copy of the consent form approved by IRB. 
• A list of current members of the IRB. 
Ⅱ. While the Study Is in Progress 
• Acknowledgment of receipt of the test and control articles; documentation of 
disposition of all test and control articles. 
• Original Case Report Forms for each subject enrolled in the study. 
• Information regarding all deviations from the protocol. 
• Information regarding all adverse events occurring to a subject while enrolled in the 
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• Annual progress report (if study is ongoing for more than one year). Letter from the 
IRB indicating approval of the annual progress report. 
Ⅲ．Once the Study Is Completed 
• Disposition of all used and/or unused test and control articles (where applicable), as 
well as documentation of all drug accountability. 
• A final study reports. 
 
 

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Appendix 2: Elements of Informed Consent 
Ⅰ．Elements of Informed Consent 
The following information must be provided to each subject in obtaining informed consent. If written 
consent is being obtained, the subject (or subject's legal representative) should be provided with a copy 
of the signed written ICF. 
• State that the study involves RESEARCH. 
• Explain the PURPOSE of the research. 
• Trial treatments and the probability for random assignment to each treatment. 
• State the expected DURATION of the subject's participation. 
• Describe the PROCEDURES to be followed. 
• Identify any EXPERIMENTAL procedures. 
• Describe any reasonably foreseeable RISKS OR DISCOMFORTS to the subject. 
• Describe any BENEFITS to the subject and responsibility for the subject or to others 
that may reasonably be expected from the research. 
• Note appropriate ALTERNATIVE procedures or courses of treatment, if any, that 
might be advantageous to the subject. 
• A.  Describe the extent, if any, to which CONFIDENTIALITY of records identifying 
the subject will be maintained. 
• B.  Note that the FDA MAY INSPECT the records. 
• For research involving more than minimal risk, explain if any COMPENSATION or 
medical treatments are available should injury occur. If so, explain (a) what they consist 
of, OR (b) where further information may be obtained. 
• A.  Tell whom to contact for ANSWERS to pertinent questions about (a) the research, 
and (b) research subjects' rights. 
• B.  Tell whom to contact in the event of a research-related INJURY to the subject. 
• State that: 
• Participation is VOLUNTARY, 
• Refusal to participate will involve NO PENALTY or loss of benefits to which the 
subject is otherwise entitled 
• The subject MAY DISCONTINUE participation at any time without penalty or loss of 
benefits to which the subject is otherwise entitled. 
II. Additional Elements of Informed Consent 
When appropriate, one or more of the following elements of information shall also be provided to each 
subject: 
• A statement that particular treatment or procedure may involve risks to the subject (or 
to the embryo or fetus, if the subject is or may become pregnant) which are currently 
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• Anticipated circumstances under which the subject's participation may be terminated by 
the Investigator without regard to the subject's consent. 
• Any additional costs to the subject that may result from participation in the research. 
• The consequences of a subject's decision to withdraw from the research and procedures 
for orderly termination of participation by the subject. 
• A statement that significant new findings developed during the course of the research, 
which may relate to the subject's willingness to continue participation, will be provided 
to the subject. 
• The approximate number of subjects involved in the study. 
The informed consent requirements in this protocol are not intended to preempt any 
applicable Federal, State, or local laws which require additional information to be disclosed 
for informed consent to be legally effective. 
Nothing in this protocol is intended to limit the authority of a physician to provide 
emergency medical care to the extent the physician is permitted to do so under applicable 
Federal, State, or local law. 
REFERENCE: 21 CFR Part 50.25 - PROTECTION OF HUMAN SUBJECTS, Elements of 
Informed Consent. 
 
 

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Appendix 3: Declaration of Helsinki 
 
Preamble 
1. The World Medical Association (WMA) has developed the Declaration of Helsinki as a 
statement of ethical principles for medical research involving human subjects, including 
research on identifiable human material and data. 
 
 
The Declaration is intended to be read as a whole and each of its constituent paragraphs 
should be applied with consideration of all other relevant paragraphs. 
2. Consistent with the mandate of the WMA, the Declaration is addressed primarily to 
physicians. The WMA encourages others who are involved in medical research 
involving human subjects to adopt these principles. 
 
 
General Principles 
3. The Declaration of Geneva of the WMA binds the physician with the words, “The 
health of my patient will be my first consideration," and the International Code of 
Medical Ethics declares that, "A physician shall act in the patient's best interest when 
providing medical care." 
4. It is the duty of the physician to promote and safeguard the health, well-being and rights 
of patients, including those who are involved in medical research. The physician's 
knowledge and conscience are dedicated to the fulfilment of this duty. 
5. Medical progress is based on research that ultimately must include studies involving 
human subjects. 
6. The primary purpose of medical research involving human subjects is to understand the 
causes, development and effects of diseases and improve preventive, diagnostic and 
therapeutic interventions (methods procedures and treatments). Even the best proven 
interventions must be evaluated continually through research for their safety, 
effectiveness, efficiency, accessibility and quality. 
7. Medical research is subject to ethical standards that promote and ensure respect for all 
human subjects and protect their health and rights. 
8. While the primary purpose of medical research is to generate new knowledge, this goal 
can never take precedence over the rights and interests of individual research subjects. 
9. It is the duty of physicians who are involved in medical research to protect the life, 
health, dignity, integrity, right to self-determination, privacy, and confidentiality of 
personal information of research subjects. The responsibility for the protection of 
research subjects must always rest with the physician or other health care professionals 
and never with the research subjects, even though they have given consent. 
10. Physicians must consider the ethical, legal and regulatory norms and standards for 
research involving human subjects in their own countries as well as applicable 
international norms and standards. No national or international ethical, legal or 
regulatory requirement should reduce or eliminate any of the protections for research 
subjects set forth in this Declaration. 
11. Medical research should be conducted in a manner that minimizes possible harm to the 
environment. 
12. Medical research involving human subjects must be conducted only by individuals with 
the appropriate ethics and scientific education, training and qualifications. Research on 
patients or healthy volunteers requires the supervision of a competent and appropriately 
qualified physician or other health care professional. 
13. Groups that are underrepresented in medical research should be provided appropriate 
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14. Physicians who combine medical research with medical care should involve their 
patients in research only to the extent that this is justified by its potential preventive, 
diagnostic or therapeutic value and if the physician has good reason to believe that 
participation in the research study will not adversely affect the health of the patients 
who serve as research subjects. 
15. Appropriate compensation and treatment for subjects who are harmed as a result of 
participating in research must be ensured. 
 
 
Risks, Burdens and Benefits 
16. In medical research, most interventions involve risks and burdens. 
 
 
Medical research involving human subjects may only be conducted if the importance of 
the objective outweighs the risks and burdens to the research subjects. 
17. All medical research involving human subjects must be preceded by careful assessment 
of predictable risks and burdens to the individuals and groups involved in the research 
in comparison with foreseeable benefits to them and to other individual or groups 
affected by the condition under investigation. 
 
 
Measures to minimize the risks must be implemented. The risks must be continuously 
monitored, assessed and documented by the researcher. 
18. Physicians may not be involved in a research study involving human subjects unless 
they are confident that the risks have been adequately assessed and can be satisfactorily 
managed. 
 
When the risks are found to outweigh the potential benefits or when there is conclusive 
proof of definitive outcomes, physicians must assess whether to continue, modify or 
immediately stop the study. 
 
 
Vulnerable Groups and Individuals 
19. Some groups and individuals are particularly vulnerable and may have an increased 
likelihood of being wronged or of incurring additional harm. 
 
 
All vulnerable groups and individuals should receive specifically considered protection. 
20. Medical research with a vulnerable group is only justified if the research is responsive 
to the health needs or priorities of this group and the research cannot be carried out in a 
non- vulnerable group. In addition, this group should stand to benefit from the 
knowledge, practices or interventions that result from the research. 
 
 
Scientific Requirements and Research Protocols 
21. Medical research involving human subjects must conform to generally accepted 
scientific principles, be based on a thorough knowledge of the scientific literature, other 
relevant sources of information, and adequate laboratory and, as appropriate, animal 
experimentation. The welfare of animals used for research must be respected. 
22. The design and performance of each research study involving human subjects must be 
clearly described and justified in a research protocol. 
 
 
The protocol should contain a statement of the ethical considerations involved and 
should indicate how the principles in this Declaration have been addressed. The 
protocol should include information regarding funding, sponsors, institutional 
affiliations, potential conflicts of interest, incentives for subjects and information 
regarding provisions for treating and/or compensating subjects who are harmed as a 
consequence of participation in the research study. 
 
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provisions. 
 
 
Research Ethics Committees 
23. The research protocol must be submitted for consideration, comment, guidance and 
approval to the concerned research ethics committee before the study begins. This 
committee must be transparent in its functioning, must be independent of the researcher, 
the sponsor and any other undue influence and must be duly qualified. It must take into 
consideration the laws and regulations of the country or countries in which the research 
is to be performed as well as applicable international norms and standards but these 
must not be allowed to reduce or eliminate any of the protections for research subjects 
set forth in this Declaration. 
 
The committee must have the right to monitor ongoing studies. The researcher must 
provide monitoring information to the committee, especially information about any 
serious adverse events. No amendment to the protocol may be made without 
consideration and approval by the committee. After the end of the study, the researchers 
must submit a final report to the committee containing a summary of the study's 
findings and conclusions. 
 
 
Privacy and Confidentiality 
24. Every precaution must be taken to protect the privacy of research subjects and the 
confidentiality of their personal information. 
 
 
Informed Consent 
25. Participation by individuals capable of giving informed consent as subjects in medical 
research must be voluntary. Although it may be appropriate to consult family members 
or community leaders, no individual capable of giving informed consent may be 
enrolled in a research study unless he or she freely agrees. 
26. In medical research involving human subjects capable of giving informed consent, each 
potential subject must be adequately informed of the aims, methods, sources of funding, 
any possible conflicts of interest, institutional affiliations of the researcher, the 
anticipated benefits and potential risks of the study and the discomfort it may entail, 
post-study provisions and any other relevant aspects of the study. The potential subject 
must be informed of the right to refuse to participate in the study or to withdraw consent 
to participate at any time without reprisal. Special attention should be given to the 
specific information needs of individual potential subjects as well as to the methods 
used to deliver the information. 
 
After ensuring that the potential subject has understood the information, the physician 
or another appropriately qualified individual must then seek the potential subject's 
freely-given informed consent, preferably in writing. If the consent cannot be expressed 
in writing, the non-written consent must be formally documented and witnessed. 
 
All medical research subjects should be given the option of being informed about the 
general outcome and results of the study. 
27. When seeking informed consent for participation in a research study the physician must 
be particularly cautious if the potential subject is in a dependent relationship with the 
physician or may consent under duress. In such situations, the informed consent must 
be sought by an appropriately qualified individual who is completely independent of 
this relationship. 
28. For a potential research subject who is incapable of giving informed consent, the 
physician must seek informed consent from the legally authorized representative. These 
individuals must not be included in a research study that has no likelihood of benefit for 
them unless it is intended to promote the health of the group represented by the 
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providing informed consent, and the research entails only minimal risk and minimal 
burden. 
29. When a potential research subject who is deemed incapable of giving informed consent 
is able to give assent to decisions about participation in research, the physician must 
seek that assent in addition to the consent of the legally authorized representative. The 
potential subject's dissent should be respected. 
30. Research involving subjects who are physically or mentally incapable of giving 
consent, for example, unconscious patients, may be done only if the physical or mental 
condition that prevents giving informed consent is a necessary characteristic of the 
research group. In such circumstances the physician must seek informed consent from 
the legally authorized representative. If no such representative is available and if the 
research cannot be delayed, the study may proceed without informed consent provided 
that the specific reasons for involving subjects with a condition that renders them 
unable to give informed consent have been stated in the research protocol and the study 
has been approved by a research ethics committee. Consent to remain in the research 
must be obtained as soon as possible from the subject or a legally authorized 
representative. 
31. The physician must fully inform the patient which aspects of their care are related to the 
research. The refusal of a patient to participate in a study or the patient's decision to 
withdraw from the study must never adversely affect the patient-physician relationship. 
32. For medical research using identifiable human material or data, such as research on 
material or data contained in biobanks or similar repositories, physicians must seek 
informed consent for its collection, storage and/or reuse. There may be exceptional 
situations where consent would be impossible or impracticable to obtain for such 
research. In such situations the research may be done only after consideration and 
approval of a research ethics committee. 
 
 
 
Use of Placebo 
33. The benefits, risks, burdens and effectiveness of a new intervention must be tested 
against those of the best proven intervention(s), except in the following circumstances:
 
 
Where no proven intervention exists, the use of placebo, or no intervention, is 
acceptable;  
or 
 
Where for compelling and scientifically sound methodological reasons the use of any 
intervention less effective than the best proven one, the use of placebo, or no 
intervention is necessary to determine the efficacy or safety of an intervention and the 
patients who receive any intervention less effective than the best proven one, placebo, 
or no intervention will not be subject to additional risks of serious or irreversible harm 
as a result of not receiving the best proven intervention.  
Extreme care must be taken to avoid abuse of this option. 
 
Post-Trial Provisions 
34. In advance of a clinical trial, sponsors, researchers and host country governments 
should make provisions for post-trial access for all participants who still need an 
intervention identified as beneficial in the trial. This information must also be disclosed 
to participants during the informed consent process. 
 
 
Research Registration and Publication and Dissemination of Results 
35. Every research study involving human subjects must be registered in a publicly 
accessible database before recruitment of the first subject. 

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36. Researchers, authors, sponsors, editors and publishers all have ethical obligations with 
regard to the publication and dissemination of the results of research. Researchers have 
a duty to make publicly available the results of their research on human subjects and are 
accountable for the completeness and accuracy of their reports. All parties should 
adhere to accepted guidelines for ethical reporting. Negative and inconclusive as well as 
positive results must be published or otherwise made publicly available. Sources of 
funding, institutional affiliations and conflicts of interest must be declared in the 
publication. Reports of research not in accordance with the principles of this 
Declaration should not be accepted for publication. 
 
 
 
Unproven Interventions in Clinical Practice 
37. In the treatment of an individual patient, where proven interventions do not exist or 
other known interventions have been ineffective, the physician, after seeking expert 
advice, with informed consent from the patient or a legally authorized representative, 
may use an unproven intervention if in the physician's judgment it offers hope of saving 
life, re-establishing health or alleviating suffering. This intervention should 
subsequently be made the object of research, designed to evaluate its safety and 
efficacy. In all cases, new information must be recorded and, where appropriate, made 
publicly available. 
 
WMA Declaration of Helsinki - Ethical Principles for Medical Research Involving Human Subjects 
Adopted by the 18th WMA General Assembly, Helsinki, Finland, June 1964 and amended by the: 
29th WMA General Assembly, Tokyo, Japan, October 1975 
35th WMA General Assembly, Venice, Italy, October 1983 
41st WMA General Assembly, Hong Kong, September 1989 
48th'Wl'v.IA General Assembly; Somerset West, Republic of South Africa, October 1996 
52nd WMA General Assembly, Edinburgh, Scotland, October 2000 
53rd WMA General Assembly, Washington DC, USA, October 2002 (Note of Clarification added) 55th 
WMA General Assembly, Tokyo, Japan, October 2004 (Note of Clarification added) 
59th WMA General Assembly, Seoul, Republic of Korea, October 2008 
64th WMA General Assembly, Fortaleza, Brazil, October 2013 
 

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Clinical Study Protocol 
 
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Appendix 4: Procedures for Examinations 
1. Demographics/Eligibility, Medical/Surgical History and Concomitant Medication 
Demographics/Eligibility, medical/surgical history and concomitant medication will be 
obtained through subject interviews at Screening Visit.  Changes in concomitant 
medications will also be obtained through subject interviews at each visit.  
2. Physical Examination 
A full body systematic physical exam will be conducted during Screening Visit and Visit 
Day 56. Clinical investigator or an external internist will confirm subject's overall condition 
noting any abnormalities by a review of the following systems: e.g., head, eyes, ears, nose 
and throat (HEENT), cardiopulmonary, endocrine, gastrointestinal, 
musculoskeletal/rheumatic, neurologic/psychiatric, dermatologic, hepatic/renal systems, 
and other. 
The Clinical Investigator will assess subject's overall condition to determine qualification 
for study entry. Newly noted abnormalities or worsening of previously noted abnormalities 
found at Study Exit, or at any safety assessment visit, will be assessed as an AE. The 
Clinical Investigator should use his or her clinical judgment for appropriate treatment 
and/or medical referral. 
3. Vital Signs 
Blood pressure and heart rate will be measured at each visit using an automated or manual 
blood pressure monitor. Systolic and diastolic blood pressures will be recorded in 
millimeters of mercury (mmHg) and heart rate will be recorded in beats per minute (bpm). 
• Subject should be seated quietly in a chair with the back supported, feet on the floor, 
arm bared, and arm supported at heart level. 
• Begin the measurement after at least 5 minutes of rest 
• To ensure an accurate measurement, use an appropriately sized cuff. The cuff bladder 
should encircle at least 80% of the arm. Many adults need a large cuff 
• Take two (2) systolic/diastolic pressure and heart rate measurements separated by at 
least 30 seconds. Record each measurement in the subject's source document. 
• If the two pressure measurements differ by 5 mmHg or less, then the average of the two 
becomes the recorded pressure. For example, if the two measurements are 120/90 and 
125/95, then 122.5/92.5 is the recorded systolic/diastolic pressure. 
• If the two pressure measurements differ by more than 5 mmHg, then a third reading 
measurement is made, and the average of the three becomes the recorded pressure. For 
example, if the three measurements are 115/90, 124/96, and 120/92, then 119.7/92.7 is 
the recorded systolic/diastolic pressure. The recorded blood pressure will be the average 
of the measurements. 
• Record the heart rate. For heart rate, the average of the two (or three, if performed) 
measurements obtained becomes the recorded heart rate. 
4. EKG 
EKGs will be ordered at Screening Visit and reviewed for abnormalities by the Clinical 
Investigator prior to enrollment.  
5. Best Corrected Visual Acuity 
ETDRS chart will be used to examine BCVA at each study visit. See Appendix 4 for 
additional information.  

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Clinical Study Protocol 
 
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6. Slit-Lamp exam and Biomicroscopy 
Slit-lamp biomicroscopy will be used to examine eye structures at each study visit. A 90-
diopter lens (or equivalent) will be used to examine the retina (vitreous, optic disc, macula 
and posterior pole).  Biomicroscopy will be performed prior to injection and then again 
within 30 minutes after injection on the visit of RBM-007 or anti-VEGF injection. 
The lid, conjunctiva, cornea, anterior chamber, iris and lens will be observed with the slit-
lamp beam approximately 0.3 mm in width and 1.0 mm in length and graded on a 4-point 
scale (0-3 scale) as described below: 
Lid Redness 
None 
 
(0) = Normal 
Mild 
 
(1) = Redness of most or all the lid(s) margin OR skin  
Moderate  
(2) = Redness of most or all the lid(s) margin AND skin  
Severe  
(3) = Marked diffuse redness of both lid(s) margin AND skin 
 
Lid Edema 
None 
 
(0) = Normal 
Mild 
 
(1) = Localized to a small region of the lid(s) 
Moderate  
(2) = Diffuse, most or all the lid(s) but not prominent/protruding 
Severe   
(3) = Diffuse, most or all the lid(s) AND prominent/protruding 
 
Conjunctival (Palpebral and Bulbar) Hyperemia  
None 
 
(0) = Normal 
Mild 
 
(1) = Slight localized injection 
Moderate  
(2) = Pink color, confined to palpebral OR bulbar conjunctiva  
Severe  
(3) = Red color of the palpebral AND/OR bulbar conjunctiva 
 
Conjunctival Edema  
None 
 
(0) = Normal 
Mild 
 
(1) = Slight localized swelling 
Moderate  
(2) = Mild/medium localized swelling or mild diffuse swelling  
Severe  
(3) = Moderate diffuse swelling 
 
Corneal Edema 
None 
 
(0) = Normal 
Mild 
 
(1) = Mild, diffuse stromal haze 
Moderate   
(2) = Dense, diffuse stromal haze or bullae 
Severe  
(3) = Dense, diffuse bullae or stromal haze AND stromal edema 

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Lens 
The lens will be noted as phakic, aphakic, or pseudophakic. Phakic lens will be graded as 
described below: 
None 
 
(0) = No lens discoloration nor opacification 
Mild 
 
(1) = Yellow lens discoloration or small lens opacity (axial or peripheral)  
Moderate  
(2) = Amber lens discoloration or medium lens opacity (axial or 
peripheral)  
Severe  
(3) = Brunescent lens discoloration or complete lens opacification (no red 
reflex.) 
Anterior chamber cells and flare will be observed with a 1.0 mm in width and 1.0 mm in 
length slit beam and graded using the Standardization of Uveitis Nomenclature (SUN) scale 
(Jabs et al, 2005).  
Anterior Chamber Cells 
(0) = No cells  
(0.5) = 1-5 cells 
(1) = 6-15 cells 
(2) = 16-25 cells 
(3) = 26-50 cells 
(4) = >50 cells 
 
Anterior Chamber Flare 
(0) =None 
(1) = Faint 
(2) = Moderate (iris/lens details clear) 
(3) = Marked (iris/lens details hazy) 
(4) = Intense (fibrin/plastic aqueous)  
Iris 
The iris will be evaluated for the presence of any clinically significant abnormalities, and 
graded as either normal (within normal limits) or abnormal (clinically significant 
abnormality present). A description of any clinically significant abnormalities will be noted. 
Pupil 
The pupil will be evaluated for the presence of any clinically significant abnormalities, and 
graded as either normal (within normal limits) or abnormal (clinically significant 
abnormality present). A description of any clinically significant abnormalities will be noted. 
7. Intraocular Pressure 
IOP will be measured by applanation tonometry at each study visit. At the visit of RBM-
007 or anti-VEGF medication injection, IOP will be measured before RBM-007 or anti-
VEGF medication injection and 30 (±10) minutes after injection. If post-injection IOP is 

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Study RBM-007-001 Protocol Amendment 1 
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increased ≥10 mmHg from pre-injection IOP, the IOP will be measured again 60(±10) 
minutes following injection. If there is an increase of ≥10mmHg at 60(±10) minutes post-
injection compared to pre-injection IOP, the subject will be prescribed a topical IOP 
lowering medication until he or she returns for follow-up per the Clinical Investigator's 
discretion (an unscheduled visit may apply), and the IOP increase of≥10 mmHg shall be 
reported as an AE. 
IOP should be measured only after the biomicroscopy examination has been 
completed. 
The applanation tonometer must be calibrated for accuracy before the first subject 
undergoes screening, and periodically until the last subject has exited the study. For 
checking calibration, follow the manufacturer's instructions. 
The right eye is always tested first. At least two, and sometimes three, consecutive 
measurements are made to obtain a determination of intraocular pressure. Each IOP 
measurement should be recorded in the subject's source document and in the CRFs. 
If the two measurements differ by 2 mmHg or less, then the average of the two 
measurements becomes the recorded IOP. For example, if the two measurements are 22 and 
23, then 22.5 is the final recorded IOP. 
However, if the two measurements differ by 3 mmHg or more, then a third measurement is 
made, and the median of the three measurements becomes the recorded IOP (the median is 
the middle measurement after arraying the measurements from low to high). For example, 
if the three measurements are 15, 19, and 16, then 16 is the final recorded IOP (Sherwood et 
al 2001). 
The IOP in the left eye is then measured using the same technique. 
8. Indirect Ophthalmoscopy 
Indirect ophthalmoscopy will be performed for each eye at each visit with pupil dilation. 
Indirect ophthalmoscopy will be used to examine the retina at each study visit. Indirect 
ophthalmoscopy will be performed prior to and within 30 minutes after each RBM-007 or 
anti-VEGF medication injection. Areas to be assessed include cup to disc ratio, retina, 
macula and choroid, and vitreous. 
9. Cup/Disc Ratio 
The cup/disc ratio will be determined by the examiner and recorded using two decimal 
places (e.g., 0.8). 
10.  
Retina, Macula and Choroid 
The retina, macula and choroid will be evaluated for the presence of any clinically 
significant abnormalities, and graded as either normal (within normal limits) or abnormal 
(clinically significant abnormality present). A description of any abnormalities will be 
noted. 
11. Vitreous 
The following National Eye Institute Grading Scheme will be used to measure vitreous 
haze and opacification (Nussenblatt et al., 1985). 
 

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Vitreous Haze Scale 
Step 
Description 
(0) 
Clear 
(Trace or 0.5+) Trace 
(1+) 
Few opacities, mild blurring 
(2+) 
Significant blurring but still visible 
(3+) 
Optic nerve visible, no vessels seen 
(4+) 
Dense opacity obscures the optic nerve head 
12. Spectral Domain Optical Coherence Tomography 
Spectralis, Cirrus or 3D OCT will be utilized to take optical images of both eyes at each 
study visit. The same machine must be used consistently throughout the study for any given 
subject. SD-OCT will be performed at every study visit. 
13. Fundus Photography 
Digital color fundus photography will be taken at Baseline Visit (Day), Visit Day 28 and 
Visit Day 56. Required fields to be captured are: 
• The optic disc, Field 1 
• The macula, Field 2 
14. Fluorescein Angiography 
Fundus fluorescein angiography will be taken at Baseline Visit, Visit Day 28, and Visit Day 
56 in both eyes. Required fields to be captured are: 
• The optic disc, Field 1 
• The macula, Field 2 
15. OCT-angiography 
OCT-angiography will be taken at Baseline Visit, Visit Day 28, and Visit Day 56 in both 
eyes. 
16. Serum Pregnancy Test 
A serum pregnancy test will be conducted at Screening Visit and Visit Day 56 for all 
women of childbearing potential. A female is considered of childbearing potential unless 
she is post-menopausal (at least 24 months since last menses occurred), has had her uterus 
and/or both ovaries removed, or has had a bilateral tubal ligation. To perform the pregnancy 
test, Human chorionic gonadotropin (hCG) will be contained into serum parameters that 
will be measured. 
17. Hematology, Serum Chemistry 
Hematology and serum chemistry will be ordered to be performed at a local laboratory at 
Screening Visit and Visit Day 28. 
 
 
 

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Serum Chemistry, Hematology 
The following is a list of the minimum parameters that will be measured. Other additional 
parameters may also be reported. 
Serum Chemistry 
Hematology 
Albumin 
red blood cells (RBC) 
Creatinine 
white blood cells (WBC) 
lactate dehydrogenase (LDH) 
differential WBC 
glucose 
platelets (PLT) 
calcium 
hemoglobin (HGB) 
potassium 
hematocrit (HCT) 
sodium 
mean corpuscular volume (MCV) 
cholesterol (total, HDL and LDL) 
mean corpuscular hemoglobin (MCH) 
triglycerides 
mean corpuscular hemoglobin concentration 
(MCHC) 
urea nitrogen 
 
bilirubin (total, direct, indirect) 
 
alkaline phosphatase (ALP) 
 
alanine aminotransferase (ALT) 
 
aspartate aminotransferase(AST) 
 
gamma glutamyl transferase (GGT) 
 
Human chorionic gonadotropin(hCG)* 
 
 
Prior to enrolling a subject, the Clinical Investigator will indicate on the source document if 
any screening laboratory values exclude the subject from participating in the study (e.g., 
serum creatinine > 1.3 mg/dL). 
*conduct only at Screening Visit. 
Prior to emailing a subject, the Clinical Investigator will indicate on the source document if 
any screening laboratory values exclude the subject from participating in the study. 
18. Procedure for Plasma levels of RBM-007 
Approximately 5 mL of blood will be collected from the subject for RBM-007 analysis at 
Baseline Visit (Day 0); Visit Day 1, a Visit Day 7 (േ૚ሻ and Visit Day 28 (േ૚ሻ 
 
 

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Table 4: Protocol Amendment 01 Summary of Changes 
Page 
Section Number and Title 
Description of Change 
7-8 
1.SYNOPSIS 
Modifications were made to reflect the study design 
changes made throughout the protocol 
23 
5.1 Subject Inclusion Criteria 3 
and 7 
Rationale: To avoid narrowing the opportunities for the 
subjects to participate in the study. 
Original Text: BCVA of 65 to 20 ETDRS letters (20/50 
to 20/400) in the study eye. 
 
Amendment 01 Text: BCVA of 65 to 10 ETDRS letters 
(20/50 to ൒20/640) in the study eye. 
23 
5.1 Subject Inclusion Criteria 5 
and 9 
Rationale: To avoid narrowing the opportunities for the 
subjects to participate in the study. 
Original Text:  
Total lesion size of ൑9 disc areas, lesion containing 
൑50% hemorrhage and ൑50% subretinal fibrosis and 
൑50% retinal pigment atrophy in the study eye 
 
Amendment 01 Text:  
Total lesion size of ൑9 disc areas, lesion containing 
൑50% hemorrhage in the study eye 
23-24 
5.2 Subject Exclusion Criteria 2 
Rationale: To avoid narrowing the opportunities for the 
subjects to participate in the study. 
Original Text: BCVA worse than 20 ETDRS letters 
(20/400) in the study eye. 
 
Amendment 01 Text: BCVA worse than 10 ETDRS 
letters (20/640) in the study eye. 
No subjects have been enrolled as of September 25, 2018. This change does not affect subject safety.