Incidence of Melanoma and Non-melanoma Skin Cancer in People With Vitiligo: A Case-control Study in the United Kingdom, 2009-2020
Conditions: Vitiligo, Melanoma (Skin), Nonmelanoma Skin Cancer, Squamous Cell Carcinoma, Basal Cell Carcinoma, Actinic Keratoses
Sponsor: Momentum Data

Incidence of melanoma and non-melanoma skin cancer in 
people with vitiligo: A case-control study in the UK, 2009-
2020: Statistical Analysis Plan and Protocol 
 
Document version 
1.3 
Date 
5 July 2021 
 
 

 
Contents 
List of abbreviations ..................................................................................................................................... 4 
1. Introduction ................................................................................................................................................. 5 
1.1 Background .......................................................................................................................................... 5 
1.2. Purposes of analyses ........................................................................................................................ 6 
2. Study objectives and endpoints ........................................................................................................... 7 
2.1 Study objectives .................................................................................................................................. 7 
2.2 Primary objectives ............................................................................................................................. 7 
2.3 Secondary objectives: ....................................................................................................................... 7 
2.4 Primary endpoint ............................................................................................................................... 7 
2.5 Secondary endpoints ........................................................................................................................ 8 
2.6 Other exploratory analyses ............................................................................................................ 8 
3 General Study Design and Plan ............................................................................................................. 8 
3.1 Study Design ........................................................................................................................................ 8 
3.2 Data source and Read codes .......................................................................................................... 8 
3.3 Data extraction .................................................................................................................................... 8 
3.4 Inclusion-Exclusion Criteria and General Study Population ............................................. 9 
Definition of vitiligo cases ................................................................................................................. 9 
3.5 Baseline characteristics ................................................................................................................... 9 
4 Sample size calculations ........................................................................................................................ 10 
5 Populations to be analysed ................................................................................................................... 10 
5.1 
Inclusion Criteria ........................................................................................................................ 10 
5.2 
Exclusion Criteria ....................................................................................................................... 10 
5.3 
Matching process ........................................................................................................................ 10 
6 Statistical Analysis ................................................................................................................................... 11 
6.1 Statistical principles ........................................................................................................................ 11 

6.2 Primary Endpoint Analysis .......................................................................................................... 11 
6.3 Secondary Objective Analysis ...................................................................................................... 12 
6.4 Sensitivity analysis .......................................................................................................................... 12 
6.5 Missing data ....................................................................................................................................... 13 
7 Study Limitations ..................................................................................................................................... 13 
8 Statistical software................................................................................................................................... 13 
9 Ethics ............................................................................................................................................................. 14 
References ....................................................................................................................................................... 15 
Appendix 1 ...................................................................................................................................................... 17 
Appendix 2 ...................................................................................................................................................... 32 
Appendix 3 ...................................................................................................................................................... 33 
Appendix 4 ...................................................................................................................................................... 36 
 
 
 

 
List of abbreviations 
Abbreviation Full Form 
ADEPT 
Anonymised Data Ethics Protocols and Transparency 
AK 
Actinic keratoses 
BCC 
Basal cell carcinoma 
BMI 
Body mass index 
 
CI 
Confidence Interval 
GEP 
Good Epidemiological Practice 
GP 
General Practitioner 
GPP 
Guidelines for Good Pharmacoepidemiology Practices 
HR 
Hazard Ratio 
IEA 
International Epidemiological Association 
IMD 
Index of multiple deprivation 
IQR 
Interquartile range 
ISPE 
International Society for Pharmacoepidemiology 
NMSC 
Nonmelanoma skin cancers 
OPCRD 
Optimum Patient Care Research Database 
RECORD 
Reporting of studies conducted using observational routinely collected 
data 
SCC 
Squamous cell carcinoma 
SD 
Standard deviation 
SES 
Socio-economic status 
UK 
United Kingdom 
UV 
Ultraviolet 
 
 
 

 
1. Introduction 
1.1 Background 
Vitiligo is an acquired depigmenting cutaneous disease with an incidence of 0.5 to 2% 
worldwide. It is characterised by white patches of skin resulting from the destruction of 
melanocytes from the epidermis (1). Although the exact cause of the condition remains 
to be established, autoimmunity is an important hypothesis of the aetiology of vitiligo. It 
has been demonstrated that CD8+ T-cells play a major role in the destruction of 
melanocytes, through the recognition of melanocyte differentiation antigens (2).  
 
Genetic studies of vitiligo have greatly advanced understanding of the pathobiology of the 
condition and provided insights regarding to susceptibility to skin cancer. Genome-wide 
association analyses have found that vitiligo is associated with polymorphisms in the TYR 
gene, which codes for tyrosinase, the main enzyme in melanin synthesis. The TYR allele 
that is associated with susceptibility to vitiligo may confer a degree of protection against 
melanoma because of the anti-tyrosinase immunity (3). In addition, human leukocyte 
antigen A2 which is the risk allele for the development of vitiligo was found to be 
associated with regressing melanoma, supporting the inverse relationship between 
vitiligo and melanoma (4). 
 
Although the genetic and autoimmunity profiles in vitiligo may protect against the 
development of melanoma and nonmelanoma skin cancers (NMSC), an absence of 
melanin in lesional skin and prolonged phototherapy treatment may cause concern about 
the development of skin cancer in this population (5). In a retrospective cohort study of 
479 patients with vitiligo, an overall higher incidence of NMSC in the white vitiligo cohort 
than the white US rates was reported (6). This finding was supported by a recent, 
nationwide, control-matched cohort study conducted in Korea assessing 131,245 patients. 
The authors reported that, taking into account of the important cofounders (e.g. 
ultraviolet treatment), people with vitiligo were 3.4 and 1.3 times more likely to get 
melanoma and nonmelanoma skin cancer (NMSC), respectively, than those without 
vitiligo (7).  

 
In contrast to the above-mentioned studies, Teulings and colleagues (8), in a large 
comparative cohort, Dutch, survey-based study in 2013, found a 3-fold lower probability 
of developing melanoma and NMSC in those with vitiligo. Stratification of the results into 
subgroups of patients treated with narrowband ultraviolet (UV) B, and psoralen and UV-
A did not find increased lifetime prevalence of melanoma or NMSC. A subsequent study 
conducted in Italy by Paradisi and colleagues (9) also reported that patients with vitiligo 
had a significantly lower probability of developing melanoma or NMSC than those with a 
non-dermatological condition. However, a markedly higher risk (14.1% vs 3.2%) was 
noted in patients treated with phototherapy compared with the control group. 
 
Overall, the risk of melanoma and NMSC in vitiligo is still being debated and further 
research is needed in this field.  
1.2. Purposes of analyses 
To the best of our knowledge, there have not been any large population-based studies in 
the UK assessing the incidence of melanoma and NMSC in patients with vitiligo compared 
with people without the condition. The purpose of this study is therefore to fill this data 
gap, and to examine whether the susceptibility to melanoma and NMSC may vary between 
different patient subgroups, e.g. ethnicity, those who undergo phototherapy or treatment 
with the new targeted biologic immunosuppressive therapies. Such new insights will be 
valuable for clinicians in advising patients with vitiligo on sun-related behaviour and 
treatment options in the UK. 
 
 

2. Study objectives and endpoints 
2.1 Study objectives 
The overall purpose of this study is to examine whether the risk of skin cancer is higher 
in people diagnosed with vitiligo compared to people without vitiligo. 
2.2 Primary objectives 
• Describe the risk of new onset skin cancer in adults diagnosed with vitiligo in a 
contemporary real-world population compared with matched controls without 
vitiligo. 
• Describe the risk of new onset skin cancer in adults diagnosed with vitiligo by 
sociodemographic subgroups. 
2.3 Secondary objectives: 
• Describe the prevalence of skin cancer in adults diagnosed with vitiligo compared 
with matched controls without vitiligo. 
• Describe the prevalence of individual skin cancer types in adults diagnosed with 
vitiligo compared with matched controls without vitiligo. 
• Describe the risk of new onset actinic keratoses (AK) in adults diagnosed with 
vitiligo compared with matched controls without vitiligo. 
• Examine the prevalence of AK in adults diagnosed with vitiligo compared with 
matched controls without vitiligo. 
2.4 Primary endpoint 
• The skin cancer outcome comprises of the composite of melanoma and NMSC. 
NMSC comprises squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). 
When more than one of melanoma,  SCC and BCC occur, the skin cancer diagnosis 
date will be the earliest of these cancers. 
• The primary endpoint is time to first diagnosis of new onset skin cancer during 
the study follow up period. 

2.5 Secondary endpoints 
• The prevalence (those diagnosed prior to the study period) of any skin cancer and 
each individual skin cancer in each study group. 
• The secondary endpoint for new onset AK is the time to first diagnosis of AK 
during the study follow up period. 
2.6 Other exploratory analyses 
If there is sufficient information in the primary care record, we will examine the 
possibility of comparing the primary endpoints in those people with a documented 
history of immunotherapy use (compared the those without) and those people with a 
documented history of phototherapy treatment (compared the those without). Data on 
phototherapy treatment may be insufficient to enable comparisons, if this is the case, this 
will be reported as a limitation of the study. 
3 General Study Design and Plan 
3.1 Study Design 
A matched-cohort design will be used to compare the risk of new onset skin cancers.  The 
study will use a case-control design to compare the prevalence of skin cancers. 
3.2 Data source and Read codes 
This study will use routinely collected and collated data from the Optimum Patient Care 
Research Database (OPCRD). (10) This database incorporates pseudonymised primary 
care records from up to 700 GP practices distributed across England, Wales, Scotland and 
Northern Ireland. The current OPCRD cohort size is over 5 million actively registered 
people, and historic records available for 10.1 million people. 
3.3 Data extraction 
Individual patient data is anonymised at the point of data extraction. Queries will be 
executed to extract relevant data from the OPCRD using the Read code listed in Appendix 
1. All data will remain in anonymised form and will be held on a secure server. The data 
will not be used for any purposes other than for the research which is described in the 

respective protocols and which has been approved by OPC. The sponsor, Pfizer Ltd, will 
not have access to the individual anonymised patient data. 
3.4 Inclusion-Exclusion Criteria and General Study Population 
Definition of vitiligo cases 
We will identify all people diagnosed with vitiligo using diagnostic Read and SNOMED CT 
codes which are specific to vitiligo (Appendix 1). A diagnostic algorithm will be used to 
facilitate robust case identification of vitiligo. This algorithm will identify anyone with a 
vitiligo specific diagnosis code followed by exclusion of anyone with a diagnosis code for 
an alternative depigmenting disorder coded within a one-year period (six months before 
or after their first vitiligo diagnosis code). The list of alternative depigmenting disorders 
is shown in Appendix 2. We will include people diagnosed with vitiligo prior to the study 
period (referred to as prevalent vitiligo) and people newly diagnosed with vitiligo during 
the study period (referred to as incident vitiligo) as vitiligo cases for the risk of new onset 
of skin cancers analysis. Only people with incident vitiligo will be included as cases in 
prevalence analysis. 
 
The study index date for people diagnosed with vitiligo will be the latest of; the start date 
of follow-up (1st Jan 2010), date of registration with GP plus six months, or the date of 
diagnosis of vitiligo. 
3.5 Baseline characteristics 
A fully list of the study variables is provided in Appendix 3. Sociodemographic groups will 
be defined by age category (18-44, 45-64, ≥65), sex, socio-economic status (SES), and 
ethnicity. SES will be defined using the official national deprivation measure; index of 
multiple deprivation (IMD).(11) This will be calculated at the point of data extraction, 
using patient postcode, with the resultant scores stratified by deprivation quintile 
according to the national distribution. Ethnicity will be grouped into major ethnic groups 
to be consistent with the UK official census categories: White, Black African/Caribbean, 
Asian, Mixed, and Other(12, 13). Other clinical covariates comprised BMI category, 
smoking status, alcohol use, and common comorbidities (hypertension, hyperlipidaemia, 
type 2 diabetes, atrial fibrillation, angina, myocardial infarction, stroke, heart failure, 

chronic kidney disease stages 3-5, chronic obstructive pulmonary disease, asthma, 
chronic liver disease, and dementia). These will be identified using clinical codes and test 
results recorded in the patient record. 
4 Sample size calculations 
No previous UK population-based studies have examined skin cancer risk in people with 
vitiligo to provide an estimation of effect size to inform our sample size calculation. 
Assuming 80% power, a 1:1 ratio of vitiligo cases to controls, and an overall probability 
of melanoma over the study period of 0.45% (a conservative estimate based on a previous 
analysis of melanoma incidence in the general population (14)) a sample size of  6,177 
will be required to detect a minimum clinically relevant effect size of a 80% decreased 
risk of melanoma in the vitiligo cohort compared to population controls. We anticipate 
c.22,500 people in our study cohort will be defined as vitiligo cases, these will be 1:1 
matched to population controls providing a study cohort well in excess of this required 
sample size. 
5 Populations to be analysed 
5.1 Inclusion Criteria 
All eligible adult patients (aged ≥18) registered with GP practices contributing data to 
OPCRD between January 1, 2010 and December 31, 2020, are eligible for inclusion in the 
study. People diagnosed with vitiligo prior to the study period (prevalent vitiligo) and 
people newly diagnosed with vitiligo during the study period (incident vitiligo) will  be 
included as cases. 
5.2 Exclusion Criteria 
People actively registered with the GP practice at that date without a history of vitiligo 
require a minimum one-year registration with their GP practice. 
5.3 Matching process 
Each adult with vitiligo (prevalent or incident) will be 1:1 matched at their index date 
using, nearest neighbour matching (30) with an unaffected control (people without 
vitiligo prior to or during the study period). Matching variables will comprise age, sex, 

duration of practice registration and within primary care practice where numbers allow. 
After matching, the index date for each control will be set at the index date of their 
matched counterpart. 
6 Statistical Analysis 
6.1 Statistical principles 
The mean, standard deviation (sd) and any other statistical measures, will be reported to 
one decimal place. Continuous data will be summarised in the form of means, sd, median, 
interquartile range (IQR) and range as appropriate. Categorical data will be summarised 
using frequencies and proportions. Chi-squared and t-tests will be performed to compare 
the frequency of dichotomous variables and the values of continuous variables where 
relevant. 95% CIs will be reported for main effect sizes.  Statistical significance will be 
assessed using p<0.05.  Actual p-values will be reported except for p-values less than 3 
decimal places which will be reported as “<0.001”. P-values >0.1 will be reported to one 
decimal place, p-values between 0.01 and 0.1 will be reported to 2 decimal places, and p-
values between 0.001 and 0.01 will be reported to three decimal places.   
 
The assessment of any associations with baseline characteristics and the primary 
endpoint will be assessed using Cox proportional hazards models. A standard set of 
features will be used in all multivariable models as listed in section 6.2. 
 
Assumptions of statistical approaches will be assessed, and transformations used if 
necessary (although it is not anticipated that the data will violate model assumptions). 
6.2 Primary Endpoint Analysis 
Risk of new onset skin cancer will be assessed prospectively in vitiligo cases (prevalent 
and incident vitiligo, refer to section 3.4) and matched controls from the index date. 
Endpoints will be identified using the clinical codes described in Appendix 4. Only vitiligo 
cases where both the vitiligo case and their matched counterpart do not have skin cancer 
at their index date will be included. We will then estimate risk of skin cancer over the 
study period starting from the index date for both vitiligo cases and controls,  The end of 
follow-up will be defined as the earliest of the study end-date (December 31, 2020), the 

date of patient transfer from an included general practice, date of death, or the date an 
individual first developed skin cancer. Risk of developing skin cancer will then be 
examined using time to failure analysis. Initially, unadjusted Cox proportional hazards 
models, stratified by matched set (vitiligo cases versus matched controls), will be used to 
provide overall hazard ratios (HRs) as summary estimates for the association of the 
presence of vitiligo with the time to skin cancer. Models will subsequently be adjusted for 
baseline sociodemographic, history of immunotherapy use or phototherapy treatment, 
prior vitiligo disease duration, and comorbidities (hypertension, hyperlipidaemia, type 2 
diabetes, atrial fibrillation, angina, myocardial infarction, stroke, heart failure, chronic 
kidney disease stages 3-5, chronic obstructive pulmonary disease, asthma, chronic liver 
disease, and dementia) in multivariable analysis. 
 
This primary endpoint analysis will be repeated in sociodemographic subgroups defined 
by age, sex, SES and ethnicity. 
6.3 Secondary Objective Analysis 
Prevalence of skin cancer and each individual cancer type (melanoma, SCC, BCC and AK)  
will be examined in incident vitiligo cases (refer to section 3.4) and compared to matched 
controls without vitiligo. Prevalence will be estimated at the index date for both cases and 
matched controls.  
 
Risk of new onset as described in the primary endpoint analysis will be repeated for each 
individual cancer type (melanoma, SCC, BCC and AK). 
6.4 Sensitivity analysis 
To evaluate the magnitude of potential bias from including, as matched controls, people 
who are registered with GP practices but who do not attend their practice, we also 
repeated the primary analysis including only controls with a least one primary care 
consultation in the year preceding their index date. 
 
As part of developing the vitiligo case definition we will explore the numbers of people 
excluded by each alternative diagnosis. If an alternative diagnosis is found to be common 
and lead to exclusion of a large proportion of the potential cohort (e.g. >10%) then 

sensitivity analysis will be performed to identify any effect of removing that particular 
exclusion criteria on: 1) the study cohort demographics and 2) any associations with the 
outcome measures. These analyses may lead to an updated case definition which will be 
reported in full in the final project manuscript. 
6.5 Missing data 
This study will use the missing indicator variable method as missing data are considered 
likely not to be missing at random, meaning multiple imputation approaches will lack 
validity.  
 
Patient will need to be excluded from analyses based on a matched design if they have 
incomplete data in the fields (age, sex) required to run the matching process. In similar 
studies, the exclusion rate due to incomplete data has been low (15, 16).  
7 Study Limitations 
Although the data is derived from a validated and nationally representative sample of the 
UK, results should not be extrapolated to dissimilar populations. Important limitations of 
the study include the reliance on comprehensive code lists to identify any given baseline 
or outcome variable. This limitation is common to all studies using routinely recorded 
data and will be mitigated through the use of a validated approach for defining baseline 
and outcome parameters. (17) 
 
Limitations exist in the amount of clinical detail presently recorded in routine primary 
care electronic health records. Routine primary care databases offer the benefit of large 
cohorts at the expense of granularity; a limitation that is universal in epidemiological 
studies of this type. Some analyses will be restricted to people in whom complete 
information is available which may introduce selection bias as a result. Finally, the data 
presented will be observational in nature and although attempts will be made to reduce 
confounding by statistical adjustment where relevant, it is not possible to exclude the 
possibility of residual confounding as part of the explanation for any findings. 
8 Statistical software 
All statistical analyses will be performed using R software version 3.4.1. 

9 Ethics 
This study requires approval by the Anonymised Data Ethics Protocols and Transparency 
(ADEPT) Committee. It has been uploaded to ClinicalTrials.gov.  
 
This study will be conducted in accordance with legal and regulatory requirements, as 
well as with scientific purpose, value, and rigor and follow generally accepted research 
practices described in Guidelines for Good Pharmacoepidemiology Practices (GPP) issued 
by the International Society for Pharmacoepidemiology (ISPE), and Good Epidemiological 
Practice (GEP) guidelines issued by the International Epidemiological Association (IEA). 
Study reporting will be conducted in accordance with the RECORD (Reporting of studies 
conducted using observational routinely collected data) guidelines.(18) 
 

References 
1. 
Steiner D, Bedin V, Moraes MB, Villas RT, Steiner T. Vitiligo. Anais Brasileiros de 
Dermatologia. 2004;79:335-51. 
2. 
Ongenae K, Van Geel N, Naeyaert JM. Evidence for an autoimmune pathogenesis of 
vitiligo. Pigment Cell Res. 2003;16(2):90-100. 
3. 
Bishop DT, Demenais F, Iles MM, Harland M, Taylor JC, Corda E, et al. Genome-wide 
association study identifies three loci associated with melanoma risk. Nat Genet. 
2009;41(8):920-5. 
4. 
Liu JB, Li M, Chen H, Zhong SQ, Yang S, Du WD, et al. Association of vitiligo with 
HLA-A2: a meta-analysis. J Eur Acad Dermatol Venereol. 2007;21(2):205-13. 
5. 
Rodrigues M. Skin Cancer Risk (Nonmelanoma Skin Cancers/Melanoma) in Vitiligo 
Patients. Dermatologic Clinics. 2017;35(2):129-34. 
6. 
Hexsel CL, Eide MJ, Johnson CC, Krajenta R, Jacobsen G, Hamzavi I, et al. Incidence 
of nonmelanoma skin cancer in a cohort of patients with vitiligo. Journal of the American 
Academy of Dermatology. 2009;60(6):929-33. 
7. 
Kim HS, Kim HJ, Hong ES, Kim KB, Lee JD, Kang TU, et al. The incidence and 
survival of melanoma and nonmelanoma skin cancer in patients with vitiligo: a nationwide 
population-based matched cohort study in Korea. British Journal of Dermatology.n/a(n/a). 
8. 
Teulings HE, Overkamp M, Ceylan E, Nieuweboer-Krobotova L, Bos JD, Nijsten T, et 
al. Decreased risk of melanoma and nonmelanoma skin cancer in patients with vitiligo: a survey 
among 1307 patients and their partners. Br J Dermatol. 2013;168(1):162-71. 
9. 
Paradisi A, Tabolli S, Didona B, Sobrino L, Russo N, Abeni D. Markedly reduced 
incidence of melanoma and nonmelanoma skin cancer in a nonconcurrent cohort of 10,040 
patients with vitiligo. J Am Acad Dermatol. 2014;71(6):1110-6. 
10. 
OPCRD. OPCRD The Optimum Patient Care Research Database 2016 [Available from: 
http://optimumpatientcare.org/opcrd/. 
11. 
Department for Communities and Local Government. The English Indices of 
Deprivation. 2015.2015. Available from: https://www.gov.uk/government/statistics/english-
indices-of-deprivation-2015. 
12. 
Office for National Statistics. Ethnicity2018 2nd January 2020. Available from: 
https://www.ons.gov.uk/peoplepopulationandcommunity/culturalidentity/ethnicity. 
13. 
Tippu Z, Correa A, Liyanage H, Burleigh D, McGovern A, Van Vlymen J, et al. 
Ethnicity Recording in Primary Care Computerised Medical Record Systems: An Ontological 
Approach. J Innov Health Inform. 2017;23(4):920. 
14. 
Memon A, Bannister P, Rogers I, Sundin J, Al-Ayadhy B, James PW, et al. Changing 
epidemiology and age-specific incidence of cutaneous malignant melanoma in England: An 
analysis of the national cancer registration data by age, gender and anatomical site, 
1981&#x2013;2018. The Lancet Regional Health – Europe. 2021;2. 
15. 
Kumar S, de Lusignan S, McGovern A, Correa A, Hriskova M, Gatenby P, et al. 
Ischaemic stroke, haemorrhage, and mortality in older patients with chronic kidney disease 
newly started on anticoagulation for atrial fibrillation: a population based study from UK 
primary care. Bmj. 2018;360:k342. 
16. 
Rayner LH, Mcgovern A, Sherlock J, Gatenby P, Correa A, Creagh-Brown B, et al. The 
impact of therapy on the risk of asthma in type 2 diabetes. Clin Respir J. 2019;13(5):299-305. 
17. 
de Lusignan S, Liaw ST, Michalakidis G, Jones S. Defining datasets and creating data 
dictionaries for quality improvement and research in chronic disease using routinely collected 
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18. 
Benchimol EI, Smeeth L, Guttmann A, Harron K, Moher D, Petersen I, et al. The 
REporting of studies Conducted using Observational Routinely-collected health Data 
(RECORD) statement. PLoS Med. 2015;12(10):e1001885. 
 
 
 

Appendix 1 
Codes to be used to identify cases of vitiligo and important exclusion conditions (see also 
Appendix 2).  
 
Read and SNOMED codes to be used to identify cases of vitiligo  
Read V2 Code 
Term 
ID 
Description 
M2951 
All 
Vitiligo 
M293. 
All 
Hypopigmentation disorder 
F4E53 
All 
Vitiligo of eyelid  
M295. 
All 
Leucoderma 
M295z 
All 
Leucoderma NOS 
Read CTV3 Code 
Term 
ID 
Description 
M2951 
All 
Vitiligo 
M293. 
All 
Hypopigmentation disorder 
F4E53 
All 
Vitiligo of eyelid  
M295. 
All 
Acquired hypomelanosis 
M295z 
All 
Leucoderma NOS 
SNOMED Code 
Term 
ID 
Description 
56727007 
 
Vitiligo (disorder) 
87666009 
 
Vitiligo of eyelid (disorder) 
721539008 
 
Vitiligo of eyelid and periocular area (disorder) 
 403271008 
 
Kobner vitiligo (disorder) 
403270009 
 
Trichrome vitiligo (disorder) 
403267005 
 
Localised vitiligo (disorder) 
403268000 
 
Segmental vitiligo (disorder) 
402621008 
 
Idiopathic vitiligo (disorder) 
403269008 
 
Generalised vitiligo (disorder) 
33093100011910
6 
 
Vitiligo of skin of left eyelid and periocular area (disorder) 
33093100011910
4 
 
Vitiligo of skin of right eyelid and periocular area (disorder) 
33091100011910
1 
 
Vitiligo of skin of left upper eyelid and periocular area 
(disorder) 
33088100011910
1 
 
Vitiligo of skin of right upper eyelid and periocular area 
(disorder) 
726608002 
 
Spastic 
paraparesis, 
vitiligo, 
premature 
greying, 
characteristic facies syndrome 
23006000 
 
Hypopigmentation of skin (disorder) 
89031001 
 
Hypopigmentation (morphological abnormality) 
68210006 
 
Hypopigmentation of eyelid  

18655006 
 
Dipigmentation 
23267004 
 
Achromia of skin (disorder) 
402807009 
 
Circumscribed hypomelanosis (disorder) 
 
 
Read codes and SNOMED codes to be used to identify alternative depigmenting disorders 
for exclusion  
Congenital and Genetic Hypomelanoses 
Read V2 Code 
Term 
ID 
Description 
C302A 
All 
Piebaldism 
PK5.. 
All 
Tuberous sclerosis 
PKy54 
All 
Waardenburg's syndrome 
C3029 
All 
Hermansky-Pudlak 
PKy92 
All 
Menke's syndrome 
Read CTV3 Code 
Term 
ID 
Description 
X78Ve 
All 
Hypomelanosis of Ito 
XaZqX 
All 
Piebaldism 
PK5.. 
All 
Tuberous sclerosis 
X78E7 
All 
Ash leaf spot, tuberous sclerosis 
X78E8 
All 
Shargreen patch 
X78E9 
All 
Adenoma sebaceum 
X20Ex 
All 
Hermansky-Pudlak syndrome 
X20ij 
All 
Griscelli syndrome with immunodeficiency 
PKy92 
All 
Menkes syndrome 
SNOMED Code 
Term 
ID 
Description 
 218358001 
 
Incontinentia pigmenti achromians syndrome (disorder) 
718122005 
Piebaldism (disorder) 
7199000 
 
Tuberous sclerosus syndrome (disorder) 
254243001 
 
Ash leaf spot, tuberous sclerosis (disorder) 
 36025004 
 
Fibrous skin tumor of tuberous sclerosis (disorder) 
254244007 
 
Shagreen patch (disorder) 
9311003 
 
Hermansky-Pudlak syndrome (disorder) 
37548006 
 
Hypopigmentation-immunodeficiency disease (disorder) 
59178007 
 
Menkes kinky-hair syndrome (disorder) 
47434006 
 
Waardenburg's syndrome (disorder) 
715952000 
 
Waardenburg syndrome co-occurrent with Hirschsprung 
disease (disorder) 
773575001 
 
Ocular albinism with congenital sensorineural deafness 
(disorder) 

765325002 
 
Peripheral 
demyelinating 
neuropathy, 
central 
dysmyelinating leukodystrophy, Waardenburg syndrome, 
Hirschsprung disease (disorder) 
Post-inflammatory Hypomelanoses 
Read V2 Code 
Term 
ID 
Description 
M2920 
All 
Post inflammatory hypopigmentation 
M170. 
All  
Lichen planus 
M1700 
All  
Lichen planus actinicus 
M1701 
All  
Lichen planus annularis 
M1702 
All  
Lichen planus atrophicus 
M1703 
All  
Lichen planus bullosus 
M1704 
All  
Lichen planus hypertrophicus  
M1705 
All  
Lichen planus linearis 
M1707 
All  
Lichen planus obtusus 
M1708 
All  
Subacute active lichen planus 
M1709 
All  
Follicular lichen planus 
M170z 
All  
Lichen planus NOS 
M17y0 
All  
Lichen ruber moniliforme  
M1650 
All 
Pityriasis alba 
M2102 
All 
Lichen sclerosus and atrophicus 
K276. 
All 
Balanitis xerotica obliterans 
Read CTV3 Code 
Term 
ID 
Description 
Xa0WM 
All 
Post inflammatory hypopigmentation 
M170. 
All 
Lichen planus 
X507Y 
All 
Confluent lichen planus 
X507Z 
All 
Micropaplular lichen planus 
X507a 
All 
Guttate lichen planus  
X507b 
All 
Follicular lichen planus 
M1703 
All 
Bullous lichen planus 
M1701 
All 
Annular lichen planus 
M1704 
All 
Hypertrophic lichen planus 

M1702 
All 
Atrophic lichen planus 
M1705 
All 
Linear lichen planus 
X507c 
All 
Zosteriform lichen planus 
M1700 
All 
Acintic lichen planus 
X507d 
All 
Post inflammatory hyperpigmentation in lichen planus 
X507e 
All 
Wickham's striae in lichen planus 
X507f 
All 
Lichen planus - lupus erythematosus overlap 
X507g 
All 
Lichen planus pemphigoides 
X507h 
All 
Site-specific lichen planus 
X507i 
All 
Lichen planus of scalp 
X507j 
All 
Lichen planus of palms and soles 
X507k 
All 
Ulcerative lichen planus of palms and soles 
X507n 
All 
Mutilating lichen planus of fingers and toes 
X507l 
All 
Lichen planus of nail 
X507w 
All 
Genital lichen planus 
X408F 
All 
Lichen planus of vuvla 
X507y 
All 
Erosive lichen planus of vulva 
X507z 
All 
Lichen planus of penis 
X5080 
All 
Lichen planus of glans penis  
M1707 
All 
Lichen planus obtusus 
M1708 
All 
Subacute active lichen planus 
M170z 
All 
Lichen planus NOS 
Myu32 
All 
[X]Other lichen planus 
M17y0 
All  
Lichen ruber moniliforme  
M1650 
All 
Pityriasis alba 
M2102 
All 
Lichen sclerosus 
X50FC 
All 
Genital lichen sclerosus 
K276. 
All 
Balanitis xerotica obliterans 
X50FE 
All 
Lichen sclerosus of vulva 
X50FF 
All 
Extra genital lichen sclerosus 
X50FG 
All 
Guttate lichen sclerosus 

SNOMED Code 
Term 
ID 
Description 
277787003 
 
Post-inflammatory hypopigmentation (disorder) 
403272001 
 
Post-infective hypomelanosis (disorder) 
403276003 
 
Acquired hypomelanosis of uncertain etiology (disorder) 
4776004 
 
Lichen planus (disorder) 
263797007 
 
Lichen planus-like (qualifier value) 
4459000 
 
Linear lichen planus (disorder) 
6111009 
 
Bullous lichen planus (disorder) 
238666005 
 
Lichen planus of lips (disorder) 
201001005 
 
Lichen planus obtusus (disorder) 
200999007 
 
Actinic lichen planus (disorder) 
238658001 
 
Lichen planus of nail (disorder) 
238668006 
 
Genital lichen planus (disorder) 
201000006 
 
Annular lichen planus (disorder) 
238647005 
 
Guttate lichen planus (disorder) 
237112004 
 
Lichen planus of vulva (disorder) 
400108007 
 
Flexural lichen planus (disorder) 
238655003 
 
Lichen planus of scalp (disorder) 
44509000 
 
Linear lichen planus (disorder) 
25858008 
 
Atrophic lichen planus (disorder) 
238670002 
 
Lichen planus of penis (disorder) 
238645002 
 
Confluent lichen planus (disorder) 
717061002 
 
Lichen planus pigmentosus (disorder) 
238648000 
 
Zosteriform lichen planus (disorder) 
238653005 
 
Lichen planus pemphigoides (disorder) 
68266006 
 
Hypertrophic lichen planus (disorder) 
238646001 
 
Micropapular lichen planus (disorder) 
64540004 
 
Lichen planopilaris (disorder) 
238654004 
 
Site-specific lichen planus (disorder) 
238652000 
 
Lichen planus-lupus erythematosus overlap (disorder) 
403198004 
 
Lichenoid actinic keratosis (disorder) 
723003004 
 
Acute eruptive lichen planus (disorder) 
238671003 
 
Lichen planus of glans penis (disorder) 
68266006 
 
 Hypertrophic lichen planus (disorder) 
201002003 
 
Subacute active lichen planus (disorder) 
720493003 
 
Annular atrophic lichen planus (disorder) 

238651007 
 
Wickham's striae in lichen planus (disorder) 
201001005 
 
Lichen planus obtusus (disorder) 
402349005 
 
Chronic lichen planus (disorder) 
238668006 
 
Genital lichen planus (disorder) 
238656002 
 
Lichen planus of palms and soles (disorder) 
402352002 
 
Poikiloderma due to lichen planus (disorder) 
721171007 
 
Hypertrophic lichen planus of vulva (disorder) 
402348002 
 
Köbner reaction from lichen planus (disorder) 
238657006 
 
Ulcerative lichen planus of palms and soles (disorder) 
238660004 
 
Mutilating lichen planus of fingers and toes (disorder) 
726476005 
 
Lichen planus co-occurrent with onycholysis (disorder) 
238649008 
 
Post-inflammatory hyperpigmentation in lichen planus 
(disorder) 
402296004 
 
Pityriasis alba (disorder) 
402298003 
 
Diffuse pityriasis alba (disorder) 
402297008 
 
Localised pityriasis alba (disorder) 
25674000 
 
Lichen sclerosus et atrophicus (disorder) 
402423004 
 
Adult lichen sclerosus (disorder) 
782666006 
 
Lichen sclerosus of anus (disorder) 
238934003 
 
Guttate lichen sclerosus (disorder) 
238932004 
 
Genital lichen sclerosus (disorder) 
700082001 
 
Lichen sclerosus of penis (disorder) 
26348009 
 
Lichen sclerosus et atrophicus of the vulva (disorder) 
402424005 
 
Childhood lichen sclerosus (disorder) 
403566002 
 
Anogenital lichen sclerosus (disorder) 
238933009 
 
Extragenital lichen sclerosus (disorder) 
402714001 
 
Lichen sclerosus of male genitalia (disorder) 
402715000 
 
Lichen sclerosus of female genitalia (disorder) 
402422009 
 
Bullous extragenital lichen sclerosus (disorder) 
721199003 
 
Prepubertal lichen sclerosus of vulva (disorder) 
403568001 
 
Localized extragenital lichen sclerosus (disorder) 
402421002 
 
Generalized extragenital lichen sclerosus (disorder) 
403564004 
 
Lichen sclerosus of penis, childhood form (disorder) 
111023000 
 
Lichen sclerosus et atrophicus, bullous type (disorder) 
403565003 
 
Vulval lichen sclerosus, childhood form (disorder) 
198033005 
 
Balanitis xerotica obliterans (disorder) 
Post Traumatic Leukoderma 
SNOMED Code 
Term 
ID 
Description 
402622001 
 
Hypomelanosis due to scarring (disorder) 
18655006 
 
Depigmentation (morphologic abnormality) 
23006000 
 
Hypopigmentation of skin (disorder) 
398656003 
 
Acquired hypomelanotic disorder (disorder) 
Para-Malignant Hypomelanoses 

Read V2 Code 
Term 
ID 
Description 
B621. 
All 
Mycosis fungoides 
B6210 
All 
Mycosis fungoides of unspecified site 
B6211 
All 
Mycosis fungoides of lymph nodes of head, face and neck 
B6212 
All 
Mycosis fungoides of intrathoracic lymph nodes 
B6213 
All 
Mycosis fungoides of intra-abdominal lymph nodes 
B6214 
All 
Mycosis fungoides of lymph nodes of axilla and upper limb 
B6215 
All 
Mycosis fungoides of lymph nodes of inguinal region and leg  
B6216 
All 
Mycosis fungoides of intrapelvic lymph nodes  
B6217 
All 
Mycosis fungoides of spleen 
B6218 
All 
Mycosis fungoides of lymph nodes of multiple sites 
B621z 
All 
Mycosis fungoides NOS 
BBI.. 
All 
[M]Mycosis fungoides 
BBI0. 
All 
[M]Mycosis fungoides 
BBI1. 
All 
[M]Sezary's disease 
BBIz. 
All 
[M]Mycosis fungoides NOS 
B62xX 
All 
0th and unspecif peripheral & cutaneous T-cell lymphomas 
B62E7 
All 
Subcutaneous panniculitis like T-cell lymphoma 
BBmD. 
All 
[M]Cutaneous lymphoma  
B622. 
All 
Sezary's disease 
B6220 
All 
Sezary's disease of unspecified site 
B6221 
All 
Sezary's disease of lymph nodes of head, face and neck 
B6222 
All 
Sezary's disease of intrathoracic lymph nodes 
B6223 
All 
Sezary's disease of intra-abdominal lymph nodes 
B6224 
All 
Sezary's disease of lymph nodes of axilla and upper limb 
B6225 
All 
Sezary's disease of lymph nodes of inguinal region and leg  
B6226 
All 
Sezary's disease of intrapelvic lymph nodes  
B6227 
All 
Sezary's disease of spleen 
B6228 
All 
Sezary's disease of lymph nodes of multiple sites 
B622z 
All 
Sezary's disease NOS 
BBEA. 
All 
Amelanotic melanoma 
Read CTV3 Code 
Term 
ID 
Description 
B621. 
All 
Mycosis fungoides 
XaQbT 
All 
Poikiloderma vasculare atrophicans 
X78hm 
All 
Mycosis fungoides of skin 
B6210 
All 
Mycosis fungoides of unspecified site 
B6211 
All 
Mycosis fungoides of lymph nodes of head, face and neck 
B6212 
All 
Mycosis fungoides of intrathoracic lymph nodes 
B6213 
All 
Mycosis fungoides of intra-abdominal lymph nodes 
B6214 
All 
Mycosis fungoides of lymph nodes of axilla and upper limb 
B6215 
All 
Mycosis fungoides of lymph nodes of inguinal region and leg  
B6216 
All 
Mycosis fungoides of intrapelvic lymph nodes  
B6217 
All 
Mycosis fungoides of spleen 

B6218 
All 
Mycosis fungoides of lymph nodes of multiple sites 
B621z 
All 
Mycosis fungoides NOS 
B622. 
All 
Sezary's disease 
B6220 
All 
Sezary's disease of unspecified site 
B6221 
All 
Sezary's disease of lymph nodes of head, face and neck 
B6222 
All 
Sezary's disease of intrathoracic lymph nodes 
B6223 
All 
Sezary's disease of intra-abdominal lymph nodes 
B6224 
All 
Sezary's disease of lymph nodes of axilla and upper limb 
B6225 
All 
Sezary's disease of lymph nodes of inguinal region and leg  
B6226 
All 
Sezary's disease of intrapelvic lymph nodes  
B6227 
All 
Sezary's disease of spleen 
B6228 
All 
Sezary's disease of lymph nodes of multiple sites 
B622z 
All 
Sezary's disease NOS 
X78hn 
All 
Sezary's disease of skin 
X78hl 
All 
Cutaneous lymphoma 
XaYin 
All 
Cutaneous follicle centre lymphoma 
Xa0Sz 
All 
Cutaneous/peripheral T-cell lymphoma 
XaYjf 
All 
Subcutaneous panniculitis like T-cell lymphoma 
ByuDD 
All 
[X]0th and unspecif peripheral & cutaneous T-cell 
lymphomas 
XaYjl 
All 
Primary cutaneous CD30 antigen positive large T-cell 
lymphoma 
XaOCE 
All 
Amelanotic malignant melanoma of skin  
SNOMED Code 
Term 
ID 
Description 
90120004 
 
Mycosis fungoides (morphologic abnormality) 
118618005 
 
Mycosis fungoides (disorder) 
765328000 
 
Classic mycosis fungoides (disorder) 
404115006 
 
Bullous mycosis fungoides (disorder) 
94714002 
 
Mycosis fungoides of spleen (disorder) 
404117003 
 
Spongiotic mycosis fungoides (disorder) 
68129100011910
5 
 
History of mycosis fungoides (situation) 
418628003 
 
Follicular mycosis fungoides (morphologic abnormality) 
404113004 
 
Tumour stage mycosis fungoides (disorder) 
404118008 
 
Syrngotropic mycosis fungoides (disorder) 
404112009 
 
Granulomatous mycosis fungoides (disorder) 
404114005 
 
Erythrodermic mycosis fungoides (disorder) 
404110001 
 
Hypomelanocytic mycosis fungoides (disorder) 
404109006 
 
Folliculotropic mycosis fungoides (disorder) 
404108003 
 
Pokilodermatous mycosis fungoides (disorder) 
404107008 
 
Patch/plaque stage mycosis fungoides (disorder) 
404116007 
 
Mycosis fungoides with systemic infiltration (disorder) 
94708009 
 
Mycosis fungoides of intrapelvic lymph nodes (disorder) 

94707004 
 
Mycosis fungoides of intra-abdominal lymph nodes 
(disorder) 
188627002 
 
Mycosis fungoides of  lymph nodes of multiple sites 
(disorder) 
404111002 
 
Lymphomatoid papulosis-associated mycosis fungoides 
(disorder) 
404104001 
 
Lymphomatoid papulosis type B mycosis fungoides-like 
(disorder) 
94715001 
 
Mycosis fungoides of extranodal AND/OR solid organ site 
(disorder) 
94709001 
 
Mycosis fungoides of intrathoracic lymph nodes (disorder) 
94711005 
 
Mycosis fungoides of lymph nodes of head, face AND/OR 
neck (disorder) 
94710006 
 
Mycosis fungoides of lymph nodes of axilla AND/OR upper 
limb (disorder) 
188627002 
 
Mycosis fungoides of lymph nodes of multiple sites 
(disorder) 
94712003 
 
Mycosis fungoides of lymph nodes of inguinal region 
AND/OR lower limb (disorder) 
28054005 
 
Cutaneous T-cell lymphoma, no International Classifcation 
of 
Diseases 
for 
oncology 
subtype 
(morphologic 
abnormality) 
40012207 
 
Primary cutaneous T-cell lymphoma (disorder) 
277613000 
 
Cutaneous/peripheral T-cell lymphoma (disorder) 
404128004 
 
CD-30 negative cutanoeus T-cell lymphoma (disorder) 
419283005 
 
Primary 
cutaneous 
T-cell 
lymphoma 
- 
category 
(morphologic abnormality) 
128804002 
 
Primary 
cutaneous 
CD30 
antigen 
positive 
T-cell 
lymphoproliferative disorder (morphologic abnormality) 
450908002 
 
Primary 
cutaneous 
gamma-delta 
T-cell 
lymphoma 
(morphologic abnormality) 
12257100011910
6 
 
History of primary cutaneous T-cell lymphoma (situation) 
419018000 
 
Primary cutaneous large T-cell lymphoma - category 
(morphologic abnormality) 
402880009 
 
Primary cutaneous large T-cell lymphoma (disorder) 
404133000 
 
Subcutaneous panniculitic cutaneous T-cell lymphoma 
(disorder) 
404128004 
 
CD-30 negative cutaneous T-cell lymphoma (disorder) 
787198005 
 
Primary cutaneous acral CD8 positive T-cell lymphoma 
(morphologic abnormality) 
397352006 
 
Primary cutaneous anaplastic large T-cell lymphoma, CD30-
positive (morphologic abnormality) 
733627006 
 
Primary cutaneous gamma-delta-positive T-cell lymphoma 
(disorder) 

404129007 
 
CD-30 negative anaplastic large T-cell cutaneous lymphoma 
(disorder) 
12257100011910
6 
 
History of malignant cutaneous T-cell lymphoma (situation) 
404130002 
 
CD-30 negative pleomorphic large T-cell cutaneous 
lymphoma (disorder) 
404126000 
 
CD-30 positive pleomorphic large T-cell cutaneous 
lymphoma (disorder) 
419283005 
 
Primary 
cutaneous 
T-cell 
lymphoma 
- 
category 
(morphologic abnormality) 
450908002 
 
Primary cutaneous gamma-delta T-cell lymphoma - category 
(morphologic abnormality) 
765136002 
 
Primary cutaneous CD8 positive aggressicve epidermotropic 
cytotoxic T-cell lymphoma (disorder) 
128875000 
 
Primary cutaneous CD30 antigen positive large T-cell 
lymphoma (disorder) 
733895005 
 
Primary cutaneous CD8 positive aggressicve epidermotropic 
cytotoxic T-cell lymphoma (morphologic abnormality) 
419586003 
 
Primary cutaneous T-cell lymphoma, large cell, CD30-
negative (morphological abnormality) 
118611004 
 
Sezary's disease (disorder) 
4950009 
 
Sezary's disease (morphologic abnormality) 
255101006 
 
Sezary disease of skin (disorder) 
95263006 
 
Sezary's disase of spleen (disorder) 
188632001 
 
Sezary's disase of intra-abdominal lymph nodes (disorder) 
188635004 
 
Sezary's disase of intrapelvic lymph nodes (disorder) 
188631008 
 
Sezary's disase of intrathoracic lymph nodes (disorder) 
188637007 
 
Sezary disease of lymph nodes of multiple sites (disorder) 
95264000 
 
Sézary's disease of extranodal AND/OR solid organ site 
(disorder) 
 188633006 
 
Sézary's disease of lymph nodes of axilla and upper limb 
(disorder) 
95260009 
 
Sézary's disease of lymph nodes of head, face AND/OR neck 
(disorder) 
188634000 
 
Sézary's disease of lymph nodes of inguinal region and 
lower limb (disorder) 
95261008 
 
Sézary's disease of lymph nodes of inguinal region AND/OR 
lower limb (disorder) 
419392005 
 
Primary cutaneous lymphoma (morphologic abnormality) 
82321000000106 
 
Tumour and germline whole genome sequencing for 
anaplastic lymphoma kinase negative anaplastic large cell 
lymphoma 
including 
primary 
cutaneous 
subtypes 
(procedure) 
403274000 
 
Hypomelanosis 
surrounding 
malignant 
melanoma 
(disorder) 

402563000 
 
Metastatic 
malignant 
melanoma 
with 
diffuse 
hypermelanosis (disorder) 
276751004 
 
Amelanotic malignant melanoma of skin (disorder) 
70594002 
 
Amelanotic melanoma (morphologic abnormality) 
404110001 
 
Hypomelanotic mycosis fungoides (disorder) 
402623006 
 
Hypomelanosis 
surrounding 
melanocytic 
neoplasm 
(disorder) 
Occupational/drug induced hypomelanoses 
Read V2 Code 
Term 
ID 
Description 
M293. 
All 
Hypopigmentation 
Read CTV3 Code 
Term 
ID 
Description 
X508z 
All 
Occupational vitiligo 
X78VE 
All 
Chemically-induced hypomelanosis 
X50Gx 
All 
Drug-induced hypomelanosis  
Xa1aV 
All 
Chemically-induced hypomelanosis 
M2950 
All 
Leucoderma aestivale 
M295. 
All 
Acquired hypomelanosis 
SNOMED Code 
Term 
ID 
Description 
238713002 
 
Occupational vitiligo (disorder) 
280962005 
 
Chemically-induced hypomelanosis (disorder) 
402622001 
 
Hypomelanosis due to scarring (disorder) 
403807001 
 
Phylloid hypomelanosis (disorder) 
398656003 
 
Acquired hypomelanotic disorder (disorder) 
238999005 
 
Drug-induced hypomelanosis (disorder) 
403698000 
 
Laser-induced hypopigmentation (disorder) 
402622001 
 
Hypomelanosis due to scarring (disorder) 
280962005 
 
Chemically-induced hypomelanosis (disorder) 
403692004 
 
Hypomelanosis due to cryotherapy (disorder) 
403744007 
 
Arsenic-induced "rain-drop" hypomelanosis (disorder) 
403698000 
 
Laser-induced hypopigmentation (disorder) 
 201290009 
 
Leukoderma estivale (disorder) 
Para-infectious hypopigmentation 
Read V2 Code 
Term 
ID 
Description 
AB10. 
All 
 
Pityriasis versicolor 
 
Read CTV3 Code 
Term 
ID 
Description 
AB10. 
All 
Pityriasis versicolor 

SNOMED Code 
Term 
ID 
Description 
56454009 
 
Pityriasis versicolor (disorder) 
18097004 
 
Malassezia (organism) 
721794002 
 
Infection caused by Malassezia (disorder) 
402133004 
 
Malassezia infection of the skin (disorder) 
29619007 
 
Malassezia furfur (organism) 
Others (including Melasma, Morphoea, Idiopathic guttate hypomelanosis, Xeroderma 
pigmentosum, Progressive macular hypomelanosis, Nevus depigmentosus, Cutaneous 
sarcoidosis) 
Read V2 Code 
Term 
ID 
Description 
M290. 
All 
Melasma 
M2900 
All 
Chloasma bronzinum 
M2901 
All 
Chloasma cachecticorum 
M2902 
All 
Chloasma caloricum 
M2903 
All 
Chloasma gravidarum 
M2903 
All 
Chloasma gravidarum 
M2903 
All 
Chloasma gravidarum 
M290z 
All 
Chloasma NOS 
M2103 
All 
Morphoea 
M2104 
All 
Linear Morphoea 
M210. 
All 
Circumscribed scleroderma 
M2100 
All 
Unspecified circumscribed scleroderma 
M2101 
All 
Localised dermatosclerosis 
M210z 
All 
Circumscribed scleroderma NOS 
PH322 
All 
Xeroderma pigmentosum 
BBE9. 
All 
[M]Nonpigmented naevus 
AD530 
All 
Lupus Pernio 
AD53. 
All 
Sarcoidosis of skin 
Read CTV3 Code 
Term 
ID 
Description 
M290. 
All 
Melasma 
Xa1aM 
All 
Drug-induced melasma 
M2900 
All 
Chloasma bronzinum 
M2901 
All 
Chloasma cachecticorum 
M2902 
All 
Chloasma caloricum 
M2904 
All 
Chloasma hepaticum 
M2905 
All 
Chloasma toxicum 
M2906 
All 
Chloasma traumaticum 
M290z 
All 
Chloasma NOS 
M2903 
All 
Melasma of pregnancy 
Xa1aM 
All 
Drug-induced melasma 

M2103 
All 
Morphoea 
X7053 
All 
Generalised morphoea 
M2101 
All 
Localised morphoea  
M2100 
All 
Unspecified circumscribed scleroderma 
M210z 
All 
Circumscribed scleroderma NOS 
X7055 
All 
Linear morphoea 
PH322 
All 
Xeroderma pigmentosum 
X78Cz 
All 
Xeroderma pigmentosum group A 
X78D0 
All 
Xeroderma pigmentosum group B 
X78D1 
All 
Xeroderma pigmentosum group C 
X78D2 
All 
Xeroderma pigmentosum group D 
X78D3 
All 
Xeroderma pigmentosum group E 
X78D4 
All 
Xeroderma pigmentosum group F 
X78D5 
All 
Xeroderma pigmentosum group G 
X78D6 
All 
Xeroderma pigmentosum XP variant  
X78D7 
All 
De Sanctis-Cacchione syndrome 
X78D8 
All 
Xerodermoid, pigmented 
X50lw 
All 
Symmetrical progressive leucopathy 
X20GW 
All 
Cutaneous sarcoid 
X20GX 
All 
Orofacial sarcoid 
X20GY 
All 
Lupus pernio 
X5089 
All 
Acute skin sarcoidosis 
X508A 
All 
Sarcoidosis-induced erythema nodosum 
X508B 
All 
Lofgrens syndrome 
X508C 
All 
Maculopapular sarcoidosis 
X508D 
All 
Chronic skin sarcoidosis 
X508E 
All 
Sarcoidosis in scar 
X508F 
All 
Papular sarcoidosis 
X508G 
All 
Lichenoid sarcoidosis 
X508H 
All 
Nodular sarcoidosis 
X508I 
All 
Angiolupoid sarcoidosis 
X00YQ 
All 
Sarcoid skin of eyelid  
X20G5 
All 
Sarcoid dactylitis 
X50Dy 
All 
Subacute nodular migratory panniculitis  
X50Dz 
All 
Subcutaneous lipogranulomatosis 
SNOMED Code 
Term 
ID 
Description 
36209000 
 
Melasma 
201274009 
 
Chloasma bronzinum (disorder) 
201275005 
 
Chloasma cachecticorum (disorder) 
201276006 
 
Chloasma caloricum (disorder) 
201277002 
 
Chloasma hepaticum (disorder) 
201278007 
 
Chloasma toxicum (disorder) 
280955001 
 
Drug-induced melasma (disorder) 

79840007 
 
Idiopathic chloasma (disorder) 
111208003 
 
Melasma gravidarum (disorder) 
54397000 
 
Symptomatic chloasma (disorder) 
201279004 
 
Chloasma traumaticum (disorder) 
201049004 
 
Morphea (disorder) 
128458002 
 
Plaque morphea (disorder) 
22784002 
 
Linear scleroderma (disorder) 
403521006 
 
Guttate morphea (disorder) 
201048007 
 
Localised morphea (disorder) 
7513007 
 
Generalized morphea (disorder) 
403522004 
 
Subcutaneous morphea (disorder) 
51156002 
 
Coup de sabre scleroderma (disorder) 
403523009 
 
Disabling pansclerotic morphea of children (disorder) 
128460000 
 
Diffuse cutaneous scleroderma (disorder) 
403524003 
 
Scleroderma-like secondary cutaneous sclerosis (disorder) 
 1717003 
 
Idiopathic guttate hypomelanosis (disorder) 
711154007 
 
Guttate hypopigmentation and punctate palmoplantar 
keratoderma with or without ectopic calcification (disorder) 
44600005 
 
Xeroderma pigmentosum (disorder) 
56048001 
 
Xeroderma pigmentosum, group E (disorder) 
25784009 
 
Xeroderma pigmentosum, group C (disorder) 
36454001 
 
Xeroderma pigmentosum, group G (disorder) 
1073003 
 
Xeroderma pigmentosum, group B (disorder) 
68637004 
 
Xeroderma pigmentosum, group D (disorder) 
42530008 
 
Xeroderma pigmentosum, group F (disorder) 
43477006 
 
Xeroderma pigmentosum, group A (disorder) 
73663008 
 
 Neurologic xeroderma pigmentosum (disorder) 
88877002 
 
Xeroderma pigmentosum, variant form (disorder) 
7806002 
 
Non-neurologic xeroderma pigmentosum (disorder) 
719819004 
 
Xeroderma pigmentosum and Cockayne syndrome complex 
(disorder) 
239083007 
 
Symmetrical progressive leucopathy (disorder) 
763368004 
 
Familial progressive hyper and hypopigmentation of skin 
(disorder) 
403541001 
 
Nevus depigmentosus 
112680001 
 
Naevus depigmentosus 
55941000 
 
Cutaneous sarcoidosis (disorder) 
238680003 
 
Papular sarcoidosis (disorder) 
 238679001 
 
Sarcoidosis in scar (disorder) 
402369000 
 
Atrophic sarcoidosis (disorder) 
402371000 
 
Verrucous sarcoidosis (disorder) 
 238681004 
 
Lichenoid sarcoidosis (disorder) 
238674006 
 
Acute skin sarcoidosis (disorder) 
402370004 
 
Ulcerative sarcoidosis (disorder) 
58870009 
 
Sarcoidosis, anular type (disorder) 

54515008 
 
Sarcoidosis, plaque type (disorder) 
80941006 
 
Subcutaneous sarcoidosis (disorder) 
 870334009 
 
Palmoplantar sarcoidosis (disorder) 
238678009 
 
Chronic skin sarcoidosis (disorder) 
238677004 
 
Maculopapular sarcoidosis (disorder) 
402368008 
 
Ichthyosiform sarcoidosis (disorder) 
402373002 
 
Hypomelanotic sarcoidosis (disorder) 
9529007 
 
Sarcoidosis, erythrodermic type (disorder) 
72470008 
 
Sarcoidosis, lupus pernio type (disorder) 
402372007 
 
Subcutaneous nodular sarcoidosis (disorder) 
 238675007 
 
Sarcoidosis-induced erythema nodosum (disorder) 
238676008 
 
Lofgrens syndrome (disorder) 
31541009 
 
Lupus pernio of Besnier 
231799005 
 
Sarcoid skin of eyelid (disorder) 

 
 
Appendix 2 
Potential differential diagnoses for vitiligo which will be used as exclusion criteria if they 
appear as diagnoses in the medical record within six months of the initial diagnosis of 
vitiligo (six months before or after the vitiligo diagnosis). *As these conditions are 
extremely uncommon in the UK they will not be used in the exclusion process. Codes for 
these conditions are listed in Appendix 1. 
 
Condition group 
Conditions/causes included 
Congenital and genetic hypomelanoses 
Piebaldism 
Tuberous sclerosis 
Hypomelanosis of Ito 
Waardenburg syndrome 
Hermanski-Pudlak syndrome 
Griscelli syndrome 
Menkes syndrome 
Post-inflammatory hypomelanoses 
Post-inflammatory leukoderma including after 
Atopic eczema or Psoriasis 
Lichen planus 
Pityriasis alba 
Lichen sclerosus 
Post traumatic leukoderma 
Post traumatic leukoderma 
Para-malignant hypomelanoses 
Cutaneous T-cell lymphoma (mycosis fungoides) 
Melanoma associated depigmentation 
Occupational/drug induced 
hypomelanoses 
Occupational vitiligo 
Other induced hypomelanoses  
Para-infectious hypopigmentation 
Pityriasis versicolor (or tinea versicolor) 
Leprosy* 
Leishmaniasis* 
Others 
Melasma 
Morphoea 
Idiopathic guttate hypomelanosis  
Xeroderma pigmentosum 
Progressive macular hypomelanosis  
Nevus depigmentosus 
Cutaneous sarcoidosis 
  
 
 
 
 
 

 
Appendix 3 
Below is a list of the variables to be extracted and utilised for the study 
Variable 
Role 
Data source(s) 
Operational 
definition 
Vitiligo 
Case definition 
OPCRD 
As defined using the 
codes listed in 
Appendix 1 
Vitiligo exclusion 
conditions 
Case definition 
OPCRD 
As defined using the 
codes listed in 
Appendix 1 and 
summarised in 
Appendix 2 
Melanoma  
Study outcome 
OPCRD 
Identified using a 
expert review list of 
clinical diagnosis codes 
from the primary care 
record. Clinical codes 
listed in Appendix 4. 
Squamous cell 
carcinoma (SCC) 
Study outcome 
OPCRD 
Identified using a 
expert review list of 
clinical diagnosis codes 
from the primary care 
record. Clinical codes 
listed in Appendix 4. 
Basal cell carcinoma 
(BCC) 
Study outcome 
OPCRD 
Identified using a 
expert review list of 
clinical diagnosis codes 
from the primary care 
record. Clinical codes 
listed in Appendix 4. 
Actinic keratoses (AK) 
Study outcome 
OPCRD 
Identified using a 
expert review list of 
clinical diagnosis codes 
from the primary care 
record. Clinical codes 
listed in Appendix 4. 
Age 
Baseline characteristic, 
predictor variable 
OPCRD 
Defined as age at the 
start of follow up 
Gender 
Baseline characteristic, 
predictor variable 
OPCRD 
Primary care recorded 
patient gender 

Socioeconomic status 
(SES) 
Baseline characteristic, 
predictor variable 
OPCRD 
Defined using patient 
index of multiple 
deprivation quintile 
Ethnicity 
Baseline characteristic, 
predictor variable 
OPCRD 
Defined using office of 
national statistics 
census categories using 
clinically coded 
ethnicity data 
Smoking status 
Baseline characteristic, 
predictor variable 
OPCRD 
Using most recent 
clinically recorded 
smoking status 
information 
Alcohol use 
Baseline characteristic, 
predictor variable 
OPCRD 
Using most recent 
clinically recorded 
alcohol use status 
information 
Body mass index (BMI) 
Baseline characteristic, 
predictor variable 
OPCRD 
Defined using most 
recent clinically 
recorded BMI 
information 
Death 
Censoring event 
OPCRD 
Identified from coding 
in the clinical record 
Deregistration from GP 
Censoring event 
OPCRD 
Identified from coding 
in the clinical record 
Atrial fibrillation 
Baseline characteristic, 
predictor variable 
OPCRD 
Identified using clinical 
codes for the condition 
Angina 
Baseline characteristic, 
predictor variable 
OPCRD 
Identified using clinical 
codes for the condition 
Myocardial infarction 
Baseline characteristic, 
predictor variable 
OPCRD 
Identified using clinical 
codes for the condition 
Congestive heart failure 
Baseline characteristic, 
predictor variable 
OPCRD 
Identified using clinical 
codes for the condition 
Stroke 
Baseline characteristic, 
predictor variable 
OPCRD 
Identified using clinical 
codes for the condition 
Diabetes type 
Baseline characteristic, 
predictor variable 
OPCRD 
Identified using clinical 
codes for the condition 
Hyperlipidaemia 
Baseline characteristic, 
predictor variable 
OPCRD 
Identified using clinical 
codes for the condition 
Hypertension 
Baseline characteristic, 
predictor variable 
OPCRD 
Identified using clinical 
codes for the condition 
Chronic kidney disease 
stages 3-5 
Baseline characteristic, 
predictor variable 
OPCRD 
Identified using clinical 
codes for the condition 
and lab test results   

Chronic obstructive 
pulmonary disease,  
Baseline characteristic, 
predictor variable 
OPCRD 
Identified using clinical 
codes for the condition 
Asthma 
Baseline characteristic, 
predictor variable 
OPCRD 
Identified using clinical 
codes for the condition 
Chronic liver disease 
Baseline characteristic, 
predictor variable 
OPCRD 
Identified using clinical 
codes for the condition 
dementia 
Baseline characteristic, 
predictor variable 
OPCRD 
Identified using clinical 
codes for the condition 
immunotherapy use 
Potential predictor 
variable 
OPCRD 
Identified using 
prescription records for 
immunotherapy 
Phototherapy 
treatment 
Potential predictor 
variable 
OPCRD 
Identified using 
prescription records 
and clinical codes for 
phototherapy 
 
 
 

Appendix 4 
Read codes and SNOMED codes to be used to identify skin cancers 
Melanoma skin cancer 
Read V2 Code 
Term 
ID 
Description 
BBE1. 
All 
[M] Melanoma NOS 
BBE10 
All 
[M] Malignant melanoma, regressing 
BBE11 
All 
[M] Desmoplastic melanoma, malignant  
7G03J 
All 
Excision of melanoma 
BBE4. 
All 
[M] Balloon cell melanoma  
BBEA. 
All 
[M] Amelanotic melanoma 
BBEC. 
All 
[M] Malignant melanoma in junctional naevus  
BBED. 
All 
[M] Precancerous melanosis NOS 
BBEE. 
All 
[M] Malignant melanoma in precancerous melanosis 
BBEF. 
All 
[M] Hutchinson's melanotic freckle 
BBEG. 
All 
[M] Malignant melanoma in Hutchinson's melanotic freckle 
BBEG0 
All 
[M]Acral lentingous melanoma, malignant  
BBEH. 
All 
[M] Superficial spreading melanoma  
BBEM. 
All 
[M] Malignant melanoma in giant pigmented naevus  
BBEP. 
All 
[M] Epitheliod cell melanoma  
BBEQ. 
All 
[M] Spindle cell melanoma, NOS 
BBER. 
All 
[M] Spindle cell melanoma, type A 
BBES. 
All 
[M] Spindle cell melanoma, type B 
BBET. 
All 
[M] Mixed epitheliod and spindle melanoma 
BBEX. 
All 
[M] Melanoma in situ 
BBEz. 
All 
[M] Naevi or melanoma, NOS 
14250 
All 
H/O Malignant Melanoma 
B828. 
All 
Melanoma in situ of skin 
B8280 
All 
Melanoma in situ of lip 
B8281 
All 
Melanoma in situ of eyelid, including canthus 
B8282 
All 
Melanoma in situ of ear and external auricular canal 
B8283 
All 
Melanoma in situ of scalp and neck 
B8284 
All 
Melanoma in situ of trunk 
B8285 
All 
Melanoma in situ of upper limb, including shoulder 

B8286 
All 
Melanoma in situ of lower limb, including hip 
B8287 
All 
Melanoma in situ of scalp  
B8288 
All 
Melanoma in situ of back of hand 
B8289 
All 
Melanoma in situ of back  
B828W 
All 
Melanoma in situ, unspecified 
B828X 
All 
Melanoma in situ of other and unspecified parts of face 
B509. 
All 
Malignant melanoma of eye 
B32.. 
All 
Malignant melanoma of skin 
B321. 
All 
Malignant melanoma of eyelid, including canthus 
B322. 
All 
Malignant melanoma of ear and external auricular canal 
B320. 
All 
Malignant melanoma of lip 
B3220 
All 
Malignant melanoma of auricle (ear) 
B3221 
All 
Malignant melanoma of external auditory meatus 
B322z 
All 
Malignant melanoma of ear and external auricular canal 
NOS 
B323. 
All 
Malignant melanoma of other and unspecified parts of face 
B3230 
All 
Malignant melanoma of external surface of cheek 
B3231 
All 
Malignant melanoma of chin 
B3232 
All 
Malignant melanoma of eyebrow 
B3233 
All 
Malignant melanoma of forehead 
B3234 
All 
Malignant melanoma of external surface of nose 
B3235 
All 
Malignant melanoma of temple 
B323z 
All 
Malignant melanoma of face NOS 
B324. 
All 
Malignant melanoma of scalp and neck 
B3240 
All 
Malignant melanoma of scalp   
B3241 
All 
Malignant melanoma of neck 
B324z 
All 
Malignant melanoma of scalp and neck NOS 
B325. 
All 
Malignant melanoma of trunk excluding scrotum 
B3250 
All 
Malignant melanoma of axilla 
B3251 
All 
Malignant melanoma of breast 
B3252 
All 
Malignant melanoma of buttock 
B3253 
All 
Malignant melanoma of groin 
B3254 
All 
Malignant melanoma of perianal skin 
B3255 
All 
Malignant melanoma of perineum 

B3256 
All 
Malignant melanoma of umbilicus 
B3257 
All 
Malignant melanoma of back 
B3258 
All 
Malignant melanoma of chest wall 
B325z 
All 
Malignant melanoma of trunk excluding scrotum NOS 
B326. 
All 
Malignant melanoma of upper limb and shoulder 
B3260 
All 
Malignant melanoma of shoulder 
B3261 
All 
Malignant melanoma of upper arm 
B3262 
All 
Malignant melanoma of forearm 
B3263 
All 
Malignant melanoma of hand 
B3264 
All 
Malignant melanoma of finger 
B3265 
All 
Malignant melanoma of thumb 
B326z 
All 
Malignant melanoma of upper limb and shoulder NOS 
B327. 
All 
Malignant melanoma of lower limb and hip 
B3270 
All 
Malignant melanoma of hip 
B3271 
All 
Malignant melanoma of thigh 
B3272 
All 
Malignant melanoma of knee 
B3273 
All 
Malignant melanoma of popliteal fossa area 
B3274 
All 
Malignant melanoma of lower leg 
B3275 
All 
Malignant melanoma of ankle 
B3276 
All 
Malignant melanoma of heel 
B3277 
All 
Malignant melanoma of foot 
B3278 
All 
Malignant melanoma of toe 
B3279 
All 
Malignant melanoma of great toe 
B327z 
All 
Malignant melanoma of lower limb and hip NOS 
B328. 
All 
Malignant melanoma stage IA 
B329. 
All 
Malignant melanoma stage IB 
B32A. 
All 
Malignant melanoma stage IIA 
B32B. 
All 
Malignant melanoma stage IIB 
B32C. 
All 
Malignant melanoma stage IIC 
B32D. 
All 
Malignant melanoma stage IIIA 
B32E. 
All 
Malignant melanoma stage IIIB 
B32F. 
All 
Malignant melanoma stage IIIC 
B32G. 
All 
Malignant melanoma stage IV M1a 
B32H. 
All 
Malignant melanoma stage IV M1b 

B32J. 
All 
Malignant melanoma stage IV M1c 
B32y. 
All 
Malignant melanoma of other specified skin site 
B32y0 
All 
Overlapping malignant melanoma of skin 
B32z. 
All 
Malignant melanoma of skin NOS 
4M3.. 
All 
Breslow depth for staging for melanoma 
Read CTV3 Code 
Term 
ID 
Description 
7G03J 
All 
Excision of melanoma  
XSHw6 
All 
Clark melanoma level 3 
XSHw7 
All 
Clark melanoma level 4 
XSHw8 
All 
Clark melanoma level 5 
14250 
All 
H/O Malignant melanoma 
XSHw4 
All 
Clark melanoma level 1 
XSHw5 
All 
Clark melanoma level 2 
B8280 
All 
Melanoma in situ of lip 
X78TH 
All 
In situ melanoma of skin 
B8281 
All 
Melanoma in situ of eyelid, including canthus 
B8282 
All 
Melanoma in situ of ear and external auricular canal 
B8283 
All 
Melanoma in situ of scalp and neck 
B8284 
All 
Melanoma in situ of trunk 
B8285 
All 
Melanoma in situ of upper limb, including shoulder 
B8286 
All 
Melanoma in situ of lower limb, including hip 
XaFsS 
All 
Melanoma in situ of scalp  
XaFsU 
All 
Melanoma in situ of back of hand 
XaFw7 
All 
Melanoma in situ of back  
XaFsT 
All 
Melanoma in situ of neck 
ByuF5 
All 
[X] Melanoma in situ of other and unspecified parts of face 
Xa99Y 
All 
Lentingo maligna melanoma 
X78TD 
All 
Nodular melanoma of skin 
B3270 
All 
Malignant melanoma of hip 
B3278 
All 
Malignant melanoma of toe 
XM0ps 
All 
Malignant melanoma of eye 
B320. 
All 
Malignant melaoma of lip 
B3263 
All 
Malignant melaoma of hand 
B3276 
All 
Malignant melanoma of heel 

X78bc 
All 
Malignant melanoma of iris 
B3272 
All 
Malignant melanoma of  knee 
B3241 
All 
Malignant melanoma of neck 
B32.. 
All 
Malignant melanoma of skin 
XaclU 
All 
Malignant melanoma stage IA 
XaclV 
All 
Malignant melanoma stage IB 
XaclW 
All 
Malignant melanoma stage IIA 
XaclX 
All 
Malignant melanoma stage IIB 
XaclY 
All 
Malignant melanoma stage IIC 
XaclZ 
All 
Malignant melanoma stage IIIA 
Xacla 
All 
Malignant melanoma stage IIIB 
Xaclb 
All 
Malignant melanoma stage IIIC 
Xacld 
All 
Malignant melanoma stage IV M1a 
Xacle 
All 
Malignant melanoma stage IV M1b 
Xaclf 
All 
Malignant melanoma stage IV M1c 
XaFrT 
All 
Local recurrence of malignant melanoma of skin 
X78TC 
All 
Superficial spreading malignant melanoma of skin 
X78TD 
All 
Nodular malignant melanoma of skin 
Xa0CE 
All 
Amelanotic malignant melanoma of skin 
X78TE 
All 
Acral lentiginous melanoma of skin 
XaBAw 
All 
Malignant blue naevus of skin 
X78TF 
All 
Malignant melanoma arising in intradermal naevus 
X78TG 
All 
Malignant melanoma arising in congenital naevus 
XM0ps 
All 
Malignant melanoma of eye 
B32.. 
All 
Malignant melanoma of skin 
B321. 
All 
Malignant melanoma of eyelid, including canthus 
B322. 
All 
Malignant melanoma of ear and external auricular canal 
B320. 
All 
Malignant melanoma of lip 
B3220 
All 
Malignant melanoma of auricle (ear) 
B3221 
All 
Malignant melanoma of external auditory meatus 
B322z 
All 
Malignant melanoma of ear and external auricular canal 
NOS 
B323. 
All 
Malignant melanoma of other and unspecified parts of face 
B3230 
All 
Malignant melanoma of external surface of cheek 

B3231 
All 
Malignant melanoma of chin 
B3232 
All 
Malignant melanoma of eyebrow 
B3233 
All 
Malignant melanoma of forehead 
B3234 
All 
Malignant melanoma of external surface of nose 
B3235 
All 
Malignant melanoma of temple 
B323z 
All 
Malignant melanoma of face NOS 
B324. 
All 
Malignant melanoma of scalp and neck 
B3240 
All 
Malignant melanoma of scalp   
B3241 
All 
Malignant melanoma of neck 
B324z 
All 
Malignant melanoma of scalp and neck NOS 
B325. 
All 
Malignant melanoma of trunk excluding scrotum 
B3250 
All 
Malignant melanoma of axilla 
B3251 
All 
Malignant melanoma of breast 
B3252 
All 
Malignant melanoma of buttock 
B3253 
All 
Malignant melanoma of groin 
B3254 
All 
Malignant melanoma of perianal skin 
B3255 
All 
Malignant melanoma of perineum 
B3256 
All 
Malignant melanoma of umbilicus 
XaClv 
All 
Malignant melanoma of back 
XaEGU 
All 
Malignant melanoma of chest wall 
B325z 
All 
Malignant melanoma of trunk excluding scrotum NOS 
B326. 
All 
Malignant melanoma of upper limb and shoulder 
B3260 
All 
Malignant melanoma of shoulder 
B3261 
All 
Malignant melanoma of upper arm 
B3262 
All 
Malignant melanoma of forearm 
B3263 
All 
Malignant melanoma of hand 
B3264 
All 
Malignant melanoma of finger 
B3265 
All 
Malignant melanoma of thumb 
B326z 
All 
Malignant melanoma of upper limb and shoulder NOS 
B327. 
All 
Malignant melanoma of lower limb and hip 
B3270 
All 
Malignant melanoma of hip 
B3271 
All 
Malignant melanoma of thigh 
B3272 
All 
Malignant melanoma of knee 
B3273 
All 
Malignant melanoma of popliteal fossa area 

B3274 
All 
Malignant melanoma of lower leg 
B3275 
All 
Malignant melanoma of ankle 
B3276 
All 
Malignant melanoma of heel 
B3277 
All 
Malignant melanoma of foot 
B3278 
All 
Malignant melanoma of toe 
B3279 
All 
Malignant melanoma of great toe 
B327z 
All 
Malignant melanoma of lower limb and hip NOS 
B32y. 
All 
Malignant melanoma of other specified skin site 
B32y0 
All 
Overlapping malignant melanoma of skin 
B32z. 
All 
Malignant melanoma of skin NOS 
Byu41 
All 
[X] Malignant melanoma of skin unspecified 
XE1yl 
All 
Malignant melanoma of head and neck 
XE1yn 
All 
Malignant melanoma of trunk 
X78bV 
All 
Malignant melanoma of cornea 
XE1yp 
All 
Malignant melanoma of upper limb 
XE1yr 
All 
Malignant melanoma of lower limb 
Xa0Di 
All 
Malignant melanoma of anus 
X78Xx 
All 
Malignant melanoma of vulva 
X78bw 
All 
Malignant melanoma of choriod 
XM0ps 
All 
Malignant melanoma of eye 
Xa0RU 
All 
Malignant melanoma of meninges 
XaE6A 
All 
Melanoma associated retinopathy 
ByuF6 
All 
[X] Melanoma in situ of other sites 
XSNL7 
All 
Breslow depth for staging of melanoma 
X78Fn 
All 
TNM Malignant melanoma of skin staging 
X78G8 
All 
TNM Malignant melanoma of uvea staging 
X78G9 
All 
TNM Malignant melanoma of iris staging 
X78GA 
All 
TNM Malignant melanoma of ciliary body staging 
X78GB 
All 
TNM Malignant melanoma of choriod staging 
X78G5 
All 
TNM Malignant melanoma of eyelid staging 
XaFrd 
All 
Metastasis from malignant melanoma of skin 
X78G7 
All 
TNM Malignant melanoma of conjunctiva staging 
Byu4. 
All 
[X] Melanoma and other malignant neoplasms of skin 

SNOMED Code 
Term 
ID 
Description 
2092003 
 
Malignant melanoma, no International Classification of 
Diseases for Oncology subtype (morphologic abnormality) 
 
 255012009 
 
Malignant melanoma of iris (disorder) 
399475009 
 
Minimal deviation melanoma (morphologic abnormality) 
77986002 
 
Melanoma in situ (morphologic abnormality) 
2142002 
 
Nodular melanoma (morphologic abnormality) 
399521000 
 
Necrotic melanoma (morphologic abnormality) 
423673009 
 
 Malignant melanoma of retina (disorder) 
372244006 
 
Malignant melanoma (disorder) 
726420002 
 
Meningeal melanoma (morphologic abnormality) 
276751004 
 
Amelanotic malignant melanoma of skin (disorder) 
70594002 
 
Amelanotic melanoma (morphologic abnormality) 
276821000 
 
Malignant melanoma of anus (disorder) 
103419001 
 
Clark's melanoma level (observable entity) 
177281002 
 
Excision of melanoma (procedure) 
68827007 
 
Spindle cell melanoma (morphologic abnormality) 
115223002 
 
Nevus AND/OR melanoma (morphologic abnormality) 
255015006 
 
Malignant melanoma of ciliary body (disorder) 
39274007 
 
Balloon cell melanoma (morphologic abnormality) 
21165006 
 
Clark melanoma level 3 (finding) 
83284001 
 
Clark melanoma level 1 (finding) 
276822007 
 
Malignant melanoma of rectum (disorder) 
50542000 
 
Clark melanoma level 2 (finding) 
161432005 
 
History of malignant melanoma (situation) 
16034002 
 
Clark melanoma level 5 (finding) 
1556006 
 
Clark melanoma level 4 (finding) 
109272006 
 
Melanoma in situ of lip (disorder) 
109278005 
 
Melanoma in situ of ear (disorder) 
128731008 
 
Meningeal melanomatosis (morphologic abnormality) 
109296001 
 
 Melanoma in situ of hip (disorder) 
315230006 
 
 Melanoma in situ of back (disorder) 
109266006 
 
Melanoma in situ of skin (disorder) 
302837001 
 
Lentigo maligna melanoma (disorder) 
 109282007 
 
Melanoma in situ of neck (disorder) 
254731001 
 
Nodular malignant melanoma of skin (disorder) 
 44474009 
 
Malignant melanoma in Hutchinson's melanotic freckle 
(morphologic abnormality) 
109270003 
 
Melanoma in situ of face (disorder) 
 816204007 
 
Nodular melanoma of mucous membrane (disorder) 
109266006 
 
Melanoma in situ of skin (disorder) 
 274087000 
 
Malignant melanoma of eye (disorder) 
37138001 
 
Epithelioid cell melanoma (morphologic abnormality) 
707361004 
 
Malignant melanoma of frontal sinus (disorder) 
109276009 
 
Melanoma in situ of scalp (disorder) 
188030005 
 
Malignant melanoma of lip (disorder) 
109284008 
 
Melanoma in situ of trunk (disorder) 

188068007 
 
Malignant melanoma of hip (disorder) 
698287002 
 
Malignant melanoma of gum (disorder) 
188076009 
 
Malignant melanoma of toe (disorder) 
396368008 
 
Skin melanoma TNM finding (finding) 
310498001 
 
Malignant melanoma of back (disorder) 
276821000 
 
Malignant melanoma of anus (disorder) 
255012009 
 
Malignant melanoma of iris (disorder) 
188063003 
 
Malignant melanoma of hand (disorder) 
188075008 
 
Malignant melanoma of foot (disorder) 
188070003 
 
Malignant melanoma of knee (disorder) 
93655004 
 
Malignant melanoma of skin (disorder) 
399705007 
 
Uveal melanoma TNM finding (finding) 
188038003 
 
Malignant melanoma of chin (disorder) 
399475009 
 
Minimal deviation melanoma (morphologic abnormality) 
188074007 
 
Malignant melanoma of heel (disorder) 
188046002 
 
Malignant melanoma of neck (disorder) 
698285005 
 
Malignant melanoma of ethmoid sinus (disorder) 
188052001 
 
Malignant melanoma of groin (disorder) 
866072004 
 
 Malignant melanoma of orbit (disorder) 
403923002 
 
Spindle cell malignant melanoma (disorder) 
 956331000000107 
 
Malignant melanoma stage IA (finding) 
956351000000100 
 
Malignant melanoma stage IB (finding) 
188045003 
 
Malignant melanoma of scalp (disorder) 
269579005 
 
Malignant melanoma of trunk (disorder) 
188069004 
 
 Malignant melanoma of thigh (disorder) 
707350007 
 
Malignant melanoma of accessory sinus (disorder) 
698288007 
 
Malignant melanoma of maxillary sinus (disorder) 
68827007 
 
Spindle cell melanoma (morphologic abnormality) 
399634005 
 
Choroidal melanoma, diffuse (morphologic abnormality) 
188073001 
 
Malignant melanoma of ankle (disorder) 
254896002 
 
Malignant melanoma of vulva (disorder) 
188065005 
 
Malignant melanoma of thumb (disorder) 
188049009 
 
Malignant melanoma of axilla (disorder) 
188050009 
 
Malignant melanoma of breast (disorder) 
707362006 
 
Malignant melanoma of sphenoidal sinus (disorder) 
 956411000000108 
 
Malignant melanoma stage IIC (finding 
128732001 
 
Mucosal lentiginous melanoma (morphologic abnormality) 
403927001 
 
Malignant melanoma of nail apparatus (disorder) 
231834005 
 
Malignant melanoma of eyelid (disorder) 
423673009 
 
Malignant melanoma of retina (disorder) 
698042007 
 
Malignant melanoma of tongue (disorder) 
385347004 
 
Clark melanoma level finding (finding) 
188042000 
 
Malignant melanoma of temple (disorder) 
 698286006 
 
Malignant melanoma of palate (disorder) 
956371000000109 
 
Malignant melanoma stage IIA (finding) 
109292004 
 
Melanoma in situ of shoulder (disorder) 
188064009 
 
Malignant melanoma of finger (disorder) 
956391000000108 
 
Malignant melanoma stage IIB (finding) 
188051008 
 
Malignant melanoma of buttock (disorder) 

956471000000103 
 
Malignant melanoma stage IIIC (finding) 
956431000000100 
 
Malignant melanoma stage IIIA (finding) 
255021005 
 
Malignant melanoma of choroid (disorder) 
403921000 
 
Borderline malignant melanoma (disorder) 
402559007 
 
Congenital malignant melanoma (disorder) 
372156000 
 
Malignant melanoma - category (morphologic abnormality) 
24653009 
 
Spindle cell melanoma, type A (morphologic abnormality) 
127330008 
 
Melanoma in situ by body site (disorder) 
443493003 
 
Metastatic malignant melanoma (disorder) 
 188062008 
 
Malignant melanoma of forearm (disorder) 
40244008 
 
Spindle cell melanoma, type B (morphologic abnormality) 
93223008 
 
Malignant melanoma of skin of eyebrow (disorder) 
399660006 
 
Ring melanoma of ciliary body (disorder) 
698287002 
 
Malignant melanoma of gum (disorder) 
385371006 
 
International Federation of Gynecology and Obstetrics stage 
for vulvar melanoma (observable entity) 
51757004 
 
Desmoplastic 
melanoma, 
malignant 
(morphologic 
abnormality) 
109290007 
 
Melanoma in situ of upper limb (disorder) 
274087000 
 
Malignant melanoma of eye (disorder) 
109294003 
 
Melanoma in situ of lower limb (disorder) 
109266006 
 
Melanoma in situ of skin (disorder) 
188060000 
 
Malignant melanoma of shoulder (disorder) 
403925009 
 
Neurotropic malignant melanoma (disorder) 
55320002 
 
Superficial spreading melanoma (morphologic abnormality) 
188054000 
 
Malignant melanoma of perineum (disorder) 
402562005 
 
Malignant melanoma animal-type (disorder) 
372158004 
 
Malignant 
melanoma, 
metastatic 
(morphologic 
abnormality) 
399644007 
 
Neurotropic 
melanoma, 
malignant 
(morphologic 
abnormality) 
277530005 
 
Malignant melanoma of meninges (disorder) 
302837001 
 
Lentigo maligna melanoma (disorder) 
188040008 
 
Malignant melanoma of forehead (disorder) 
39896009 
 
Malignant 
melanoma, 
regressing 
(morphologic 
abnormality) 
 403922007 
 
Balloon cell malignant melanoma (disorder) 
188061001 
 
Malignant melanoma of upper arm (disorder) 
721627007 
 
Malignant melanoma of esophagus (disorder) 
106246001 
 
International Federation of Gynecology and Obstetrics 
staging system for vulvar melanoma (tumor staging) 
188072006 
 
Malignant melanoma of lower leg (disorder) 
403924008 
 
Desmoplastic malignant melanoma (disorder) 
188055004 
 
Malignant melanoma of umbilicus (disorder) 
956551000000106 
 
Malignant melanoma stage IV M1c (finding) 
51757004 
 
Desmoplastic 
melanoma, 
malignant 
(morphologic 
abnormality) 
722689005 
 
Melanoma in situ of conjunctiva (disorder) 
956531000000104 
 
Malignant melanoma stage IV M1b (finding) 
188077000 
 
Malignant melanoma of great toe (disorder) 

18450009 
 
Malignant 
melanoma 
in 
precancerous 
melanosis 
(morphologic abnormality) 
312941005 
 
Melanoma-associated retinopathy (disorder) 
956511000000107 
 
Malignant melanoma stage IV M1a (finding) 
1556006 
 
Clark melanoma level 4 (finding) 
315036008 
 
Melanoma in situ of back of hand (disorder) 
16034002 
 
Clark melanoma level 5 (finding) 
307603002 
 
Malignant blue nevus of skin (disorder) 
313248004 
 
Malignant melanoma of chest wall (disorder) 
93640008 
 
Malignant melanoma of skin of lip (disorder) 
 93637008 
 
Malignant melanoma of skin of hip (disorder) 
93650009 
 
Malignant melanoma of skin of toe (disorder) 
255004001 
 
Malignant melanoma of conjuctiva (disorder) 
109268007 
 
Melanoma in situ of non-skin site (disorder) 
271944004 
 
Clear cell sarcoma (morphologic abnormality) 
93220006 
 
Malignant melanoma of skin of ear (disorder) 
385345007 
 
Clark system for melanoma staging (tumor staging) 
109288006 
 
 Melanoma in situ of perianal skin (disorder) 
403926005 
 
Malignant melanoma of oral cavity (disorder) 
93214005 
 
Malignant melanoma of skin of back (disorder) 
93638003 
 
Malignant melanoma of skin of knee (disorder) 
109266006 
 
Melanoma in situ of skin (disorder) 
109286005 
 
Melanoma in situ of skin of breast (disorder) 
93642000 
 
Malignant melanoma of skin of neck (disorder) 
93636004 
 
Malignant melanoma in skin of hand (disorder) 
93227009 
 
 Malignant melanoma of skin of foot (disorder) 
12622007 
 
Clear 
cell 
sarcoma 
(except 
of 
Kidney 
M-89643) 
(morphologic abnormality) 
385348009 
 
Breslow depth finding for melanoma (finding) 
 93225001 
 
Malignant melanoma of skin of face (disorder) 
93643005 
 
Malignant melanoma of skin of nose (disorder) 
 723281005 
 
Primary malignant melanoma of anus (disorder) 
698040004 
 
Malignant melanoma of nasal cavity (disorder) 
106243009 
 
Breslow depth staging for melanoma (observable entity) 
 1080941000119109  
Malignant melanoma of left choroid (disorder) 
 93219000 
 
Malignant melanoma of skin of chin (disorder) 
109296001 
 
Melanoma in situ of hip (disorder) 
 402561003 
 
 Malignant melanoma of soft tissues (disorder) 
254732008 
 
Acral lentiginous malignant melanoma of skin (disorder) 
447712006 
 
Malignant melanoma of skin of anus (disorder) 
385346008 
 
Breslow system for melanoma staging (tumor staging) 
269578002 
 
Malignant melanoma of head and neck (disorder) 
448298007 
 
Malignant melanoma of skin of penis (disorder) 
448300007 
 
Malignant melanoma of skin of vulva (disorder) 
1080981000119100 
 
Malignant melanoma of right choroid (disorder) 
698044008 
 
Malignant melanoma of palatine arch (disorder) 
698045009 
 
Malignant melanoma of buccal mucosa (disorder) 
1251000119106 
 
History of melanoma in situ of skin (situation) 
396368008 
 
Skin melanoma TNM finding (finding) 

726019003 
 
Familial malignant melanoma of skin (disorder) 
 93209006 
 
Malignant melanoma of perianal skin (disorder) 
93211002 
 
Malignant melanoma of skin of ankle (disorder) 
93217003 
 
Malignant melanoma of skin of cheek (disorder) 
93218008 
 
Malignant melanoma of skin of chest (disorder) 
93221005 
 
Malignant melanoma of skin of elbow (disorder) 
315230006 
 
Melanoma in situ of back (disorder) 
188033007 
 
Malignant melanoma of auricle (ear) (disorder) 
93654000 
 
Malignant melanoma of skin of wrist (disorder) 
 93651008 
 
Malignant melanoma of skin of trunk (disorder) 
93649009 
 
Malignant melanoma of skin of thigh (disorder) 
 93230002 
 
Malignant melanoma of skin of groin (disorder) 
93646002 
 
Malignant melanoma of skin of scalp (disorder) 
399705007 
 
Uveal melanoma TNM finding (finding) 
403920004 
 
Minimal deviation malignant melanoma (disorder) 
424190005 
 
Malignant melanoma of unknown origin (disorder) 
93226000 
 
Malignant melanoma of skin of finger (disorder) 
115561000119102 
 
History of malignant melanoma of eye (situation) 
93224002 
 
Malignant melanoma of skin of eyelid (disorder) 
352161000119100 
 
Melanoma in situ of right upper limb (disorder) 
352191000119107 
 
Melanoma in situ of right lower limb (disorder) 
109276009 
 
Melanoma in situ of skin of scalp (disorder) 
 55320002 
 
Superficial spreading melanoma (morphologic abnormality) 
93215006 
 
Malignant melanoma of skin of breast (disorder) 
93213004 
 
Malignant melanoma of skin of axilla (disorder) 
698043002 
 
Malignant melanoma of floor of mouth (disorder) 
 721563000 
 
Primary malignant melanoma of vagina (disorder) 
 722665003 
 
Primary malignant melanoma of cornea (disorder) 
866079008 
 
Malignant melanoma of lacrimal gland (disorder) 
276751004 
 
Amelanotic malignant melanoma of skin (disorder) 
402564006 
 
Multiple primary malignant melanomata (disorder) 
16974005 
 
Acral lentiginous melanoma, malignant (morphologic 
abnormality) 
783736003 
 
Malignant melanoma of mucous membrane (disorder) 
93216007 
 
Malignant melanoma of skin of buttock (disorder) 
448273006 
 
Malignant melanoma of skin of scrotum (disorder) 
93223008 
 
Malignant melanoma of skin of eyebrow (disorder) 
93228004 
 
Malignant melanoma of skin of forearm (disorder) 
188069004 
 
Malignant melanoma of thigh (disorder) 
385372004 
 
International Federation of Gynecology and Obstetrics stage 
finding for vulvar melanoma (finding) 
866072004 
 
Malignant melanoma of orbit (disorder) 
109267002 
 
Overlapping malignant melanoma of skin (disorder) 
915007 
 
Malignant melanoma in junctional nevus (morphologic 
abnormality) 
254325002 
 
Tumor-node-metastasis (TNM) malignant melanoma of skin 
staging (tumor staging) 
93229007 
 
Malignant melanoma of skin of forehead (disorder) 
254347002 
 
Tumor-node-metastasis (TNM) malignant melanoma of iris 
staging (tumor staging) 

9364004 
 
Malignant melanoma of skin of perineum (disorder) 
188044004 
 
Malignant melanoma of scalp and/or neck (disorder) 
93652001 
 
Malignant melanoma of skin of umbilicus (disorder) 
449636007 
 
Malignant melanoma of skin of lower leg (disorder) 
449637003 
 
Malignant melanoma of skin of upper arm (disorder) 
424487008 
 
Malignant melanoma of skin of upper lip (disorder) 
424302003 
 
Malignant melanoma of skin of lower lip (disorder) 
915007 
 
Malignant melanoma in junctional nevus (morphologic 
abnormality) 
956451000000107 
 
Malignant melanoma stage IIIB (finding) 
351961000119109 
 
Malignant melanoma of skin of right arm (disorder) 
399660006 
 
Ring melanoma of ciliary body (disorder) 
 254343003 
 
Tumor-node-metastasis (TNM) malignant melanoma of 
eyelid staging (tumor staging) 
698041000 
 
Malignant melanoma of vestibule of mouth (disorder) 
722543005 
 
Primary malignant melanoma of anal canal (disorder) 
402556000 
 
Malignant melanoma (radial growth phase) (disorder) 
254349004 
 
Tumor-node-metastasis (TNM) malignant melanoma of 
choroid staging (tumor staging) 
 188071004 
 
Malignant melanoma of popliteal fossa area (disorder) 
 423447006 
 
Malignant melanoma of skin of lower eyelid 
423494003 
 
Malignant melanoma of skin of upper eyelid (disorder) 
403714009 
 
Psoralen and long-wave ultraviolet radiation therapy-
associated malignant melanoma (disorder) 
314987003 
 
Metastasis from malignant melanoma of skin (disorder) 
402558004 
 
Malignant melanoma (vertical growth phase) (disorder) 
103419001 
 
Clark's melanoma level (observable entity) 
75931002 
 
Malignant 
melanoma 
of 
giant 
pigmented 
nevus 
(morphologic abnormality) 
50813003 
 
Mixed epithelioid and spindle cell melanoma (morphologic 
abnormality) 
109280004 
 
Melanoma in situ of external auditory canal (disorder 
399521000 
 
Necrotic melanoma (morphologic abnormality) 
830195005 
 
Malignant 
melanoma 
with 
B-Raf 
proto-oncogene, 
serine/threonine kinase V600E mutation (morphologic 
abnormality) 
830150003 
 
Malignant 
melanoma 
with 
B-Raf 
proto-oncogene, 
serine/threonine kinase V600E mutation (disorder) 
402560002 
 
Materno-fetal metastatic malignant melanoma  
18450009 
 
Malignant 
melanoma 
in 
precancerous 
melanosis 
(morphologic abnormality) 
423280002 
 
Malignant melanoma of skin of canthus of eye (disorder) 
109288006 
 
Melanoma in situ of perianal skin (disorder) 
402557009 
 
In situ acral lentiginous malignant melanoma (disorder) 
109286005 
 
Melanoma in situ of skin of breast (disorder) 
352201000119105 
 
Malignant melanoma of skin of left upper limb (disorder) 
396369000 
 
pTis: Melanoma in situ (melanoma of the skin) (finding) 
1081021000119100 
 
Malignant melanoma of skin of left lower limb (disorder) 
93648001 
 
Malignant melanoma of skin of temporal region (disorder) 
109274007 
 
Melanoma in situ of eyelid, including canthus (disorder) 

 188034001 
 
Malignant melanoma of external auditory meatus 
(disorder) 
352001000119100 
 
Malignant melanoma of skin of right lower limb (disorder) 
254734009 
 
Malignant melanoma arising in congenital nevus (disorder) 
 866082003 
 
Malignant melanoma of lacrimal drainage system (disorder) 
 314976006 
 
Local recurrence of malignant melanoma of skin (disorder) 
396391007 
 
 pM1b: Metastasis to lung (melanoma of the skin) (finding) 
396518001 
 
Distance of malignant melanoma from deep margin 
(observable entity) 
254733003 
 
Malignant melanoma arising in intradermal nevus 
(disorder) 
188048001 
 
Malignant melanoma of trunk (excluding scrotum) 
(navigational concept) 
93210001 
 
Malignant melanoma of skin of abdomen (disorder) 
402564006 
 
 Multiple primary malignant melanomata (disorder) 
115561000119102 
 
History of malignant melanoma of eye (situation) 
93647006 
 
Malignant melanoma of skin of shoulder (disorder) 
 44474009 
 
Malignant melanoma in Hutchinson's melanotic freckle 
(morphologic abnormality) 
75931002 
 
Malignant 
melanoma 
in 
giant 
pigmented 
nevus 
(morphologic abnormality) 
396517006 
 
Surgical deep margin involved by malignant melanoma 
(finding) 
396400002 
 
Surgical lateral margin involved by in situ melanoma 
(finding) 
399634005 
 
Choroidal melanoma, diffuse (morphologic abnormality) 
396516002 
 
Surgical deep margin uninvolved by malignant melanoma 
(finding) 
396399009 
 
Surgical lateral margin uninvolved by in situ melanoma 
(finding) 
399501001 
 
pT1: Tumor limited to the iris (iris) (uveal melanoma) 
(finding) 
396513005 
 
Surgical lateral margin involved by malignant melanoma 
(finding) 
403274000 
 
Hypomelanosis 
surrounding 
malignant 
melanoma 
(disorder) 
 396512000 
 
Surgical lateral margin uninvolved by malignant melanoma 
(finding) 
39896009 
 
Malignant 
melanoma, 
regressing 
(morphologic 
abnormality) 
 396511007 
 
Distance of in situ melanoma from closest lateral margin 
(observable entity) 
 396391007 
 
pM1b: Metastasis to lung (melanoma of the skin) (finding) 
402563000 
 
Metastatic 
malignant 
melanoma 
with 
diffuse 
hypermelanosis (disorder) 
 866073009 
 
Malignant melanoma of overlapping lesion of eye and 
adnexa (disorder) 
396515003 
 
Distance of malignant melanoma from closest lateral 
margin (observable entity) 
399679009 
 
 pT4: Tumor with extraocular extension (iris) (uveal 
melanoma) (finding) 

396517006 
 
Surgical deep margin involved by malignant melanoma 
(finding) 
 396400002 
 
Surgical lateral margin involved by in situ melanoma 
(finding) 
254346006 
 
Tumor-node-metastasis (TNM) malignant melanoma of 
uvea staging (tumor staging) 
 399717009 
 
Surgical deep margin involvement by melanoma cannot be 
assessed (finding) 
396382008 
 
pN1: Metastasis in one regional lymph node (melanoma of 
the skin) (finding) 
189324006 
 
Melanoma in situ of skin of scalp and/or neck (disorder) 
399385006 
 
Surgical lateral margin involvement by melanoma cannot be 
assessed (finding) 
188032002 
 
 Malignant melanoma of ear and/or external auditory canal 
(disorder) 
402563000 
 
Metastatic 
malignant 
melanoma 
with 
diffuse 
hypermelanosis (disorder) 
425133002 
 
Location of malignant melanoma in specimen with involved 
deep margin (observable entity) 
254345005 
 
Tumor-node-metastasis (TNM) malignant melanoma of 
conjunctiva staging (tumor staging) 
 424082007 
 
Location of melanoma in situ in specimen with involved 
lateral margin (observable entity) 
254348007 
 
Tumor-node-metastasis (TNM) malignant melanoma of 
ciliary body staging (tumor staging) 
 424949006 
 
Location of malignant melanoma in specimen with 
uninvolved deep margin (observable entity) 
18450009 
 
Malignant 
melanoma 
in 
precancerous 
melanosis 
(morphologic abnormality) 
396386006 
 
pN2a: Clinically occult (microscopic) metastasis (melanoma 
of the skin) (finding) 
396383003 
 
pN1a: Clinically occult (microscopic) metastasis (melanoma 
of the skin) (finding) 
399679009 
 
pT4: Tumor with extraocular extension (iris) (uveal 
melanoma) (finding) 
399717009 
 
Surgical deep margin involvement by melanoma cannot be 
assessed (finding) 
396384009 
 
pN1b: 
Clinically 
apparent 
(macroscopic) 
metastasis 
(melanoma of the skin) (finding) 
 396387002 
 
pN2b: 
Clinically 
apparent 
(macroscopic) 
metastasis 
(melanoma of the skin) (finding) 
406039001 
 
College of American Pathologists Cancer Checklist; Uveal 
Melanoma: Resection (record artifact) 
70046009 
 
International Federation of Gynecology and Obstetrics 
vulvar melanoma stage I (finding) 
73055006 
 
International Federation of Gynecology and Obstetrics 
vulvar melanoma stage V (finding) 
65306007 
 
International Federation of Gynecology and Obstetrics 
vulvar melanoma stage II (finding) 
80588003 
 
International Federation of Gynecology and Obstetrics 
vulvar melanoma stage IV (finding) 

65536004 
 
International Federation of Gynecology and Obstetrics 
vulvar melanoma stage III (finding) 
396377001 
 
pT3a: Melanoma 2.01 to 4.0 mm in thickness, no ulceration 
(melanoma of the skin) (finding) 
396374008 
 
pT2a: Melanoma 1.01 to 2.0 mm in thickness, no ulceration 
(melanoma of the skin) (finding) 
396386006 
 
pN2a: Clinically occult (microscopic) metastasis (melanoma 
of the skin) (finding) 
396383003 
 
pN1a: Clinically occult (microscopic) metastasis (melanoma 
of the skin) (finding) 
 396378006 
 
pT3b: Melanoma 2.01 to 4.0 mm in thickness, with 
ulceration (melanoma of the skin) (finding) 
396375009 
 
pT2b: Melanoma 1.01 to 2.0 mm in thickness, with 
ulceration (melanoma of the skin) (finding) 
399602001 
 
pT1c: Tumor limited to the iris with melanomalytic 
glaucoma (iris) (uveal melanoma) (finding) 
396387002 
 
pN2b: 
Clinically 
apparent 
(macroscopic) 
metastasis 
(melanoma of the skin) (finding) 
 396384009 
 
pN1b: 
Clinically 
apparent 
(macroscopic) 
metastasis 
(melanoma of the skin) (finding) 
399602001 
 
pT1c: Tumor limited to the iris with melanomalytic 
glaucoma (iris) (uveal melanoma) (finding) 
396380000 
 
pT4a: Melanoma greater than 4.0 mm in thickness, no 
ulceration (melanoma of the skin) (finding) 
396381001 
 
pT4b: Melanoma greater than 4.0 mm in thickness, with 
ulceration (melanoma of the skin) (finding) 
396388007 
 
pN2c: Satellite or in-transit metastasis without nodal 
metastasis (melanoma of the skin) (finding) 
399511008 
 
pT1b: Tumor limited to the iris (more than 3 clock hours in 
size) (iris) (uveal melanoma) (finding) 
422796005 
 
Location of melanoma in situ in specimen with uninvolved 
lateral margin (observable entity) 
396373002 
 
pT2: Melanoma 1.01 to 2.0 mm in thickness, with or 
without ulceration (melanoma of the skin) (finding) 
396376005 
 
pT3: Melanoma 2.01 to 4.0 mm in thickness, with or 
without ulceration (melanoma of the skin) (finding) 
396370004 
 
pT1: Melanoma 1.0 mm or less in thickness, with or without 
ulceration (melanoma of the skin) (finding) 
396390008 
 
pM1a: Metastasis to skin, subcutaneous tissues, or distant 
lymph nodes (melanoma of the skin) (finding 
399597008 
 
pT1a: Tumor limited to the iris (not more than 3 clock hours 
in size) (iris) (uveal melanoma) (finding) 
406058005 
 
College of American Pathologists Cancer Checklist; 
Melanoma of the Skin: Excision; Re-Excision (record artifact) 
396379003 
 
pT4: Melanoma greater than 4.0 mm in thickness, with or 
without ulceration (melanoma of the skin) (finding) 
396381001 
 
pT4b: Melanoma greater than 4.0 mm in thickness, with 
ulceration (melanoma of the skin) (finding) 
399615005 
 
pT2: Tumor confluent with or extending into the ciliary body 
and/or choroid (iris) (uveal melanoma) (finding) 

396371000 
 
pT1a: Melanoma 1.0 mm or less in thickness and level II or 
III, no ulceration (melanoma of the skin) (finding 
399615005 
 
pT2: Tumor confluent with or extending into the ciliary body 
and/or choroid (iris) (uveal melanoma) (finding) 
396376005 
 
pT3: Melanoma 2.01 to 4.0 mm in thickness, with or 
without ulceration (melanoma of the skin) (finding) 
396372007 
 
pT1b: Melanoma 1.0 mm or less in thickness and level IV or 
V or with ulceration (melanoma of the skin) (finding) 
 396493009 
 
pT1: Tumor 2 cm or less in greatest dimension (carcinoma 
of skin excluding eyelid, vulva, penis, and melanomas) 
(finding) 
396501000 
 
pT3: Tumor more than 5 cm in greatest dimension 
(carcinoma of skin excluding eyelid, vulva, penis, and 
melanomas) (finding) 
399557005 
 
pT3: Tumor confluent with or extending into the ciliary body 
and/or choroid with scleral extension (iris) (uveal 
melanoma) (finding) 
396501000 
 
pT3: Tumor more than 5 cm in greatest dimension 
(carcinoma of skin excluding eyelid, vulva, penis, and 
melanomas) (finding) 
 396385005 
 
pN2: Metastasis in 2 to 3 regional nodes or intralymphatic 
regional metastasis without nodal metastasis (melanoma of 
the skin) (finding) 
 399448002 
 
pT1: Tumor 10 mm or less in greatest diameter and 2.5 mm 
or less in greatest height (thickness) (ciliary body and 
choroid) (uveal melanoma) (finding) 
396392000 
 
pM1c: Metastasis to visceral site other than lung or distant 
metastasis at any site associated with an elevated serum 
lactic dehydrogenase (melanoma of the skin) (finding) 
396506005 
 
pT4: Tumor invades deep extradermal structures (i.e. 
cartilage, skeletal muscle, or bone) (carcinoma of skin 
excluding eyelid, vulva, penis, and melanomas) (finding) 
396502007 
 
pT3a: Tumor more than 5 cm in greatest dimension, limited 
to dermis or not more than 2 mm in thickness (carcinoma 
of skin excluding eyelid, vulva, penis, and melanomas) 
(finding) 
 396496001 
 
pT1c: Tumor 2 cm or less in greatest dimension, invading the 
subcutis and/or greater than 6 mm in thickness (carcinoma 
of skin excluding eyelid, vulva, penis, and melanomas) 
(finding) 
399729000 
 
pT4: Tumor more than 16 mm in greatest diameter and/or 
greater than 10 mm in maximum height (thickness) with 
extraocular extension (ciliary body and choroid) (uveal 
melanoma) (finding) 
396389004 
 
pN3: Metastasis in four or more regional nodes, or matted 
metastatic nodes, or in-transit metastasis or satellite(s) with 
metastasis in regional node(s) (melanoma of the skin) 
(finding) 
396504008 
 
pT3c: Tumor more than 5 cm in greatest dimension, 
invading the subcutis and/or greater than 6 mm in thickness 
(carcinoma of skin excluding eyelid, vulva, penis, and 
melanomas) (finding) 

 399610000 
 
pT3: Tumor more than 16 mm in greatest diameter and/or 
greater than 10 mm in maximum height (thickness) without 
extraocular extension (ciliary body and choroid) (uveal 
melanoma) (finding) 
399493005 
 
pT1c: Tumor 10 mm or less in greatest diameter and 2.5 mm 
or less in greatest height (thickness) with macroscopic 
extraocular extension (ciliary body and choroid) (uveal 
melanoma) (finding) 
399461002 
 
pT1b: Tumor 10 mm or less in greatest diameter and 2.5 mm 
or less in greatest height (thickness) with microscopic 
extraocular extension (ciliary body and choroid) (uveal 
melanoma) (finding) 
399516003 
 
pT1a: Tumor 10 mm or less in greatest diameter and 2.5 mm 
or less in greatest height (thickness) without microscopic 
extraocular extension (ciliary body and choroid) (uveal 
melanoma) (finding) 
 396507001 
 
pT4b: Tumor invades deep extradermal structures (i.e. 
cartilage, skeletal muscle, or bone) greater than 6mm in 
thickness (carcinoma of skin excluding eyelid, vulva, penis, 
and melanomas) (finding) 
396508006 
 
pT4a: Tumor invades deep extradermal structures (i.e. 
cartilage, skeletal muscle, or bone) not more than 6mm in 
thickness (carcinoma of skin excluding eyelid, vulva, penis, 
and melanomas) (finding) 
399616006 
 
pT2b: Tumor 10 mm to 16 mm in greatest basal diameter 
and between 2.5 and 10 mm in maximum height (thickness) 
with microscopic extraocular extension (ciliary body and 
choroid) (uveal melanoma) (finding) 
399543008 
 
pT2c: Tumor 10 mm to 16 mm in greatest basal diameter 
and between 2.5 and 10 mm in maximum height (thickness) 
with macroscopic extraocular extension (ciliary body and 
choroid) (uveal melanoma) (finding) 
396498000 
 
pT2a: Tumor more than 2 cm, but not more than 5 cm, in 
greatest dimension, limited to dermis or greater than 2 mm 
in thickness (carcinoma of skin excluding eyelid, vulva, 
penis, and melanomas) (finding) 
Nonmelanoma skin cancers 
Read V2 Code 
Term 
ID 
Description 
B338. 
All 
Squamous cell carcinoma of skin 
B33z. 
All 
Squamous cell carcinoma of skin NOS 
BB24. 
All 
[M] Verrucous carcinoma NOS 
B8… 
All 
Bowen's disease 
BB2L. 
All 
[M] Bowen's disease 
BB3.. 
All 
Basal cell neoplasms 
BB30. 
All 
[M]Basal cell tumour 
BB31. 
All 
[M]Basal cell carcinoma NOS 
Bb32. 
All 
[M]Multicentric basal cell carcinoma 
BB33. 
All 
[M]Basal cell carcinoma, morhoea type 
BB34. 
All 
[M]Basal cell carcinoma, fibroepithelial type 
BB35. 
All 
[M]Basosquamous carcinoma 

BB36. 
All 
[M]Metatypical carcinoma 
BB37. 
All 
[M]Intraepidermal epithelioma of Jadassohn 
BB3C. 
All 
[M]Superficial basal cell carcinoma 
BB3D. 
All 
[M]Basal cell carcinoma, nodular 
BB3E. 
All 
[M]Basal cell carcinoma, micronodular 
BB3F. 
All 
[M]Basal cell carcinoma, infiltrative 
BB3G. 
All 
[M]Pigmented basal cell carcinoma 
BB3z. 
All 
[M]Basal cell neoplasm NOS 
BB5y0 
All 
[M]Basal cell adenocarcinoma 
7G05D 
All 
Excision biopsy of basal cell carcinoma 
B33z0 
All 
Kaposi sarcoma of the skin 
BB5RA 
All 
[M]Merkel cell carcinoma 
B621. 
All 
Mycosis fungoides 
B6210 
All 
Mycosis fungoides of unspecified site 
B6211 
All 
Mycosis fungoides of lymph nodes of head, face and neck 
B6212 
All 
Mycosis fungoides of intrathoracic lymph nodes 
B6213 
All 
Mycosis fungoides of intra-abdominal lymph nodes 
B6214 
All 
Mycosis fungoides of lymph nodes of axilla and upper limb 
B6215 
All 
Mycosis fungoides of lymph nodes of inguinal region and leg  
B6216 
All 
Mycosis fungoides of intrapelvic lymph nodes  
B6217 
All 
Mycosis fungoides of spleen 
B6218 
All 
Mycosis fungoides of lymph nodes of multiple sites 
B621z 
All 
Mycosis fungoides NOS 
BBI.. 
All 
[M]Mycosis fungoides 
BBI0. 
All 
[M]Mycosis fungoides 
BBI1. 
All 
[M]Sezary's disease 
BBIz. 
All 
[M]Mycosis fungoides NOS 
B62xX 
All 
0th and unspecif peripheral & cutaneous T-cell lymphomas 
B62E7 
All 
Subcutaneous panniculitis like T-cell lymphoma 
BBmD. 
All 
[M]Cutaneous lymphoma  
B622. 
All 
Sezary's disease 
B6220 
All 
Sezary's disease of unspecified site 
B6221 
All 
Sezary's disease of lymph nodes of head, face and neck 
B6222 
All 
Sezary's disease of intrathoracic lymph nodes 
B6223 
All 
Sezary's disease of intra-abdominal lymph nodes 
B6224 
All 
Sezary's disease of lymph nodes of axilla and upper limb 
B6225 
All 
Sezary's disease of lymph nodes of inguinal region and leg  
B6226 
All 
Sezary's disease of intrapelvic lymph nodes  
B6227 
All 
Sezary's disease of spleen 
B6228 
All 
Sezary's disease of lymph nodes of multiple sites 
B622z 
All 
Sezary's disease NOS 
Read CTV3 Code 
Term ID Description 
X78el 
All 
Squamous cell carcinoma of lip 
X78bU 
All 
Squamous cell carcinoma of cornea 
X00Z8 
All 
Squamous cell carcinoma of eyelid 
X78RR 
All 
Squamous cell carcinoma of skin 
Xa34C 
All 
Squamous cell carcinoma of skin of upper lip 
Xa34D 
All 
Squamous cell carcinoma of skin of lower lip 
Xa34e 
All 
Squamous cell carcinoma of skin of cheek 

X78RS 
All 
Clear cell squamous cell carcinoma of skin 
X78RT 
All 
Spindle cell carcinoma of skin 
X78RU 
All 
Acantholytic squamous cell carcinoma of skin 
X78RV 
All 
Plantar verrucous squamous cell carcinoma of skin 
Xa0EY 
All 
Squamous cell carcinoma of scrotum 
X78Xw 
All 
Squamous cell carcinoma of vulva 
B33z. 
All 
Squamous cell carcinoma of skin NOS 
X78bM 
All 
Squamous cell carcinoma of conjunctiva 
X78gS 
All 
Squamous cell carcinoma of anal margin 
X78RW 
All 
Squamous cell carcinoma in situ of skin 
X78il 
All 
Queryat's erythroplasia 
X0027 
All 
Bowen's disease of eyelid 
XaEJc 
All 
Bowen's disease of vulva 
X78VL 
All 
Basal cell naevus syndrome 
X78SS 
All 
Basal cell carcinoma of skin 
X78ST 
All 
Basosquamous carcinomaof skin 
X78VL 
All 
Naevoid basal cell carcinoma syndrome 
X78SU 
All 
Fibroepithelioma of Pinkus 
X78VK 
All 
Follicularatrophoderma and basal cell epitheliomata 
X00Z9 
All 
Basal cell carcinoma of eyelid 
Xa7OT 
All 
Excision of basal cell carcinoma 
7G056 
All 
Excision biopsy of basal cell carcinoma 
Xa7OU 
All 
Cryotherapy of basal cell carcinoma 
X78ST 
All 
Metatypical basal cell carcinoma of skin 
X78Sg 
All 
Basal cell carcinoma with eccrine differentiation 
XM1ML 
All 
Epithelioma basal cell 
X77nR 
All 
Merkel cell carcinoma 
X78ha 
All 
Kaposi's sarcoma of skin 
X78Ut 
All 
Epitheliod sarcoma of skin 
B621. 
All 
Mycosis fungoides 
XaQbT 
All 
Poikiloderma vasculare atrophicans 
X78hm 
All 
Mycosis fungoides of skin 
B6210 
All 
Mycosis fungoides of unspecified site 
B6211 
All 
Mycosis fungoides of lymph nodes of head, face and neck 
B6212 
All 
Mycosis fungoides of intrathoracic lymph nodes 
B6213 
All 
Mycosis fungoides of intra-abdominal lymph nodes 
B6214 
All 
Mycosis fungoides of lymph nodes of axilla and upper limb 
B6215 
All 
Mycosis fungoides of lymph nodes of inguinal region and leg  
B6216 
All 
Mycosis fungoides of intrapelvic lymph nodes  
B6217 
All 
Mycosis fungoides of spleen 
B6218 
All 
Mycosis fungoides of lymph nodes of multiple sites 
B621z 
All 
Mycosis fungoides NOS 
B622. 
All 
Sezary's disease 
B6220 
All 
Sezary's disease of unspecified site 
B6221 
All 
Sezary's disease of lymph nodes of head, face and neck 
B6222 
All 
Sezary's disease of intrathoracic lymph nodes 
B6223 
All 
Sezary's disease of intra-abdominal lymph nodes 
B6224 
All 
Sezary's disease of lymph nodes of axilla and upper limb 
B6225 
All 
Sezary's disease of lymph nodes of inguinal region and leg  

B6226 
All 
Sezary's disease of intrapelvic lymph nodes  
B6227 
All 
Sezary's disease of spleen 
B6228 
All 
Sezary's disease of lymph nodes of multiple sites 
B622z 
All 
Sezary's disease NOS 
X78hn 
All 
Sezary's disease of skin 
X78hl 
All 
Cutaneous lymphoma 
XaYin 
All 
Cutaneous follicle centre lymphoma 
Xa0Sz 
All 
Cutaneous/peripheral T-cell lymphoma 
XaYjf 
All 
Subcutaneous panniculitis like T-cell lymphoma 
ByuDD 
All 
[X]0th and unspecif peripheral & cutaneous T-cell 
lymphomas 
XaYjl 
All 
Primary cutaneous CD30 antigen positive large T-cell 
lymphoma 
SNOMED Code 
Term ID  Description 
402815007 
 
Squamous cell carcinoma (disorder) 
28899001 
 
Squamous cell carcinoma, no International Classification of 
Diseases for Oncology subtype (morphologic abnormality) 
255084004 
 
Squamous cell carcinoma of anal margin (disorder) 
425303004 
 
Squamous cell carcinomatosis (disorder) 
403468003 
 
Squamous cell carcinoma of penis (disorder) 
276953005 
 
Squamous cell carcinoma of gum (disorder) 
255071008 
 
Squamous cell carcinoma of lip (disorder) 
 422599000 
 
Squamous cell carcinoma of back (disorder) 
 403896003 
 
Squamous cell carcinoma of hand (disorder) 
403895004 
 
Squamous cell carcinoma of foot (disorder) 
422572002 
 
 Squamous cell carcinoma of chin (disorder) 
448930008 
 
Squamous cell carcinoma of nose (disorder) 
59529006 
 
Squamous cell carcinoma in situ, no International 
Classification 
of 
Diseases 
for 
Oncology 
subtype 
(morphologic abnormality) 
85956000 
 
Adenoid 
squamous 
cell 
carcinoma 
(morphologic 
abnormality) 
189565007 
 
Squamous cell carcinoma in situ (disorder) 
307502000 
 
Squamous cell carcinoma of mouth (disorder) 
65692009 
 
Spindle cell carcinoma (morphologic abnormality) 
128634009 
 
Basaloid 
squamous 
cell 
carcinoma 
(morphologic 
abnormality) 
423700001 
 
Squamous cell carcinoma of auricle of ear (disorder) 
 403891008 
 
Squamous cell carcinoma of scalp (disorder) 
254895003 
 
Squamous cell carcinoma of vulva (disorder) 
255008003 
 
Squamous cell carcinoma of cornea (disorder) 
 89906000 
 
Verrucous carcinoma (morphologic abnormality) 
719052006 
 
Recurrent squamous cell carcinoma (disorder) 
425148008 
 
Squamous cell carcinoma of temple (disorder) 
39056008 
 
Papillary 
squamous 
cell 
carcinoma 
(morphologic 
abnormality) 
231831002 
 
Squamous cell carcinoma of eyelid (disorder) 
69551000119109 
 
History of squamous cell carcinoma (situation) 
64204000 
 
Squamous 
cell 
carcinoma, 
metastatic 
(morphologic 
abnormality) 

423700001 
 
Squamous cell carcinoma of auricle of ear (disorder) 
276860003 
 
Squamous cell carcinoma of scrotum (disorder) 
 403905005 
 
Multiple squamous cell carcinomata (disorder) 
403903003 
 
 Signet ring squamous cell carcinoma (disorder) | 
403893006 
 
Squamous cell carcinoma of forehead (disorder) 
399739006 
 
Metaplastic squamous cell carcinoma (morphologic 
abnormality) 
 448931007 
 
Squamous cell carcinoma of shoulder (disorder) 
 450434000 
 
Excision of squamous cell carcinoma (procedure) 
37304002 
 
Basosquamous carcinoma (morphologic abnormality) 
422676009 
 
Squamous cell carcinoma of ala nasi (disorder) 
403901001 
 
Acantholytic squamous cell carcinoma (disorder) 
10288008 
 
Squamous cell carcinoma, spindle cell (morphologic 
abnormality) 
 300987004 
 
Disseminated squamous cell carcinoma (morphologic 
abnormality) 
403900000 
 
Spindle cell squamous cell carcinoma (disorder) 
18048008 
 
Squamous cell carcinoma, keratinizing (morphologic 
abnormality) 
12478003 
 
Squamous cell carcinoma, microinvasive (morphologic 
abnormality) 
733344004 
 
Primary squamous cell carcinoma of lip (disorder 
403894000 
 
Squamous cell carcinoma of skin of ear (disorder) 
 722112006 
 
Primary squamous cell carcinoma of ear (disorder) 
733897002 
 
Pseudovascular squamous cell carcinoma (morphologic 
abnormality) 
 255003007 
 
Squamous cell carcinoma of conjunctiva (disorder) 
423896007 
 
Squamous cell carcinoma of tip of nose (disorder) 
 89906000 
 
Verrucous carcinoma (morphologic abnormality) 
423284006 
 
Squamous cell carcinoma of skin of neck (disorder) 
400066006 
 
Intraepithelial squamous cell carcinoma (disorder) 
254656002 
 
Squamous cell carcinoma in situ of skin (disorder) 
723265000 
 
Primary squamous cell carcinoma of anus (disorder) 
403892001 
 
Squamous cell carcinoma of skin of face (disorder) 
716659002 
 
Squamous cell carcinoma of head and neck (disorder) 
440527006 
 
Primary squamous cell carcinoma of naris (disorder) 
128635005 
 
Squamous cell carcinoma, clear cell type (morphologic 
abnormality) 
 45490001 
 
Squamous cell carcinoma, large cell, nonkeratinizing 
(morphologic abnormality) 
403899005 
 
Squamous cell carcinoma of skin of trunk (disorder) 
402817004 
 
Squamous cell carcinoma of nail apparatus (disorder) 
 422378004 
 
Squamous cell carcinoma of bridge of nose (disorder) 
128647004 
 
Papillary 
squamous 
cell 
carcinoma, 
non-invasive 
(morphologic abnormality) 
429024007 
 
History of squamous cell carcinoma of skin (situation) 
254652000 
 
Clear cell squamous cell carcinoma of skin (disorder) 
424260006 
 
Squamous cell carcinoma of nasolabial fold (disorder) 
403897007 
 
Squamous cell carcinoma of upper extremity (disorder) 
402816008 
 
Squamous cell carcinoma of anogenital area (disorder) 

403896003 
 
Squamous cell carcinoma of hand (disorder) 
254895003 
 
Squamous cell carcinoma of vulva (disorder) 
1082071000119102 
 
Primary squamous cell carcinoma of left ear (disorder) 
128633003 
 
Squamous 
cell 
carcinoma 
with 
horn 
formation 
(morphologic abnormality) 
403891008 
 
Squamous cell carcinoma of scalp (disorder) 
1082191000119100 
 
Primary squamous cell carcinoma of right ear (disorder) 
285308002 
 
Squamous cell carcinoma of skin of lower lip (disorder) 
285307007 
 
Squamous cell carcinoma of skin of upper lip (disorder) 
91151000119103 
 
Primary squamous cell carcinoma of chest wall (disorder) 
 789051005 
 
Squamous cell carcinoma in situ of skin caused by sunlight 
(disorder) 
403713003 
 
Psoralen and long-wave ultraviolet radiation therapy-
associated squamous cell carcinoma (disorder) 
448165009 
 
 Squamous cell carcinoma arising in chronic ulcer (disorder) 
423506005 
 
 Squamous cell carcinoma of external auditory canal 
(disorder) 
403898002 
 
 Squamous cell carcinoma of skin of lower extremity 
(disorder) 
285309005 
 
Squamous cell carcinoma of skin of cheek (disorder) 
422378004 
 
Squamous cell carcinoma of bridge of nose (disorder) 
84999002 
 
Bowen's disease (morphologic abnormality) 
45490001 
 
Squamous cell carcinoma, large cell, nonkeratinizing 
(morphologic abnormality) 
35718007 
 
Squamous cell carcinoma, small cell, nonkeratinizing 
(morphologic abnormality) 
 783212001 
 
Human papillomavirus positive squamous cell carcinoma 
(morphologic abnormality) 
1671000119100 
 
Metastasis to lymph node from squamous cell carcinoma 
(disorder) 
 399494004 
 
Squamous cell carcinoma in post-traumatic skin lesion 
(morphologic abnormality) 
783213006 
 
Human papillomavirus negative squamous cell carcinoma 
(morphologic abnormality) 
722666002 
 
Primary squamous cell carcinoma of lacrimal apparatus 
(disorder) 
418372008 
 
Squamous cell carcinoma of mucous membrane of lower lip 
(disorder) 
399582005 
 
 Squamous cell carcinoma, nonkeratinizing, differentiated 
(morphologic abnormality) 
 449778005 
 
Undifferentiated nonkeratinizing squamous cell carcinoma 
(morphologic abnormality) 
24111000119105 
 
Primary squamous cell carcinoma of upper limb (disorder) 
403890009 
 
Squamous cell carcinoma of vulva due to lichen sclerosus 
(disorder) 
 91151000119103 
 
Primary squamous cell carcinoma of chest wall (disorder) 
1082101000119106 
 
Primary squamous cell carcinoma of skin of left lower limb 
(disorder) 
242951000119108 
 
Primary squamous cell carcinoma of vermilion border of lip 
(disorder) 

789051005 
 
Squamous cell carcinoma in situ of skin caused by sunlight 
(disorder) 
1082221000119106 
 
Primary squamous cell carcinoma of skin of right lower limb 
(disorder) 
400155002 
 
Squamous cell carcinoma - category (morphologic 
abnormality) 
767544007 
 
Intraepithelial squamous cell carcinoma of anogenital 
region (disorder) 
419240004 
 
Squamous cell carcinoma of mucous membrane of upper lip 
(disorder) 
 5688000 
 
Squamous cell carcinoma in situ with questionable stromal 
invasion (morphologic abnormality) 
449778005 
 
Undifferentiated nonkeratinizing squamous cell carcinoma 
(morphologic abnormality) 
399694008 
 
Squamous 
cell 
carcinoma, 
nonkeratinizing, 
mixed 
differentiated 
and 
undifferentiated 
(morphologic 
abnormality) 
721604004 
 
Primary squamous cell carcinoma of overlapping lesion of 
male genital organ (disorder) 
448406002 
 
Grade 
III 
squamous 
intraepithelial 
neoplasia 
with 
microinvasive squamous cell carcinoma (morphologic 
abnormality) 
1338007 
 
Basal cell carcinoma (morphologic abnormality) 
402521004 
 
Basal cell carcinoma of upper extremity (disorder) 
403912001 
 
Cystic basal cell carcinoma (disorder) 
402820007 
 
Basal cell carcinoma of ear (disorder) 
402520003 
 
Basal cell carcinoma of hand (disorder) 
402519009 
 
Basal cell carcinoma of face (disorder) 
402818009 
 
Basal cell carcinoma of nose (disorder) 
399470004 
 
Basal 
cell 
carcinoma 
with 
eccrine 
differentiation 
(morphologic abnormality) 
423463003 
 
Basal cell carcinoma of back (disorder) 
402509003 
 
Basal cell carcinoma of neck (disorder) 
80071000119103 
 
 Basal cell carcinoma of skin in situ (disorder) 
403915004 
 
Basal cell carcinoma of scalp (disorder) 
717731002 
 
Basal cell carcinoma of vulva (disorder) 
402507001 
 
 Basal cell carcinoma of cheek (disorder) 
128636006 
 
Basal cell carcinoma, nodular (morphologic abnormality) 
61471000119100 
 
Basal cell carcinoma of naris (disorder) 
424666005 
 
Basal cell carcinoma of auricle of ear (disorder) 
402513005 
 
Basal cell carcinoma of tragus (disorder) 
402536001 
 
Basal cell carcinoma - primary (disorder) 
402525008 
 
Basal cell carcinoma - adenoid (disorder) 
399585007 
 
Pigmented basal cell carcinoma (morphologic abnormality) 
403909004 
 
Pigmented basal cell carcinoma (disorder) 
402538000 
 
Recurrent basal cell carcinoma (disorder) 
231832009 
 
Basal cell carcinoma of eyelid (disorder) 
403917007 
 
Basal cell carcinoma of temple (disorder) 
56665009 
 
Infiltrating basal cell carcinoma (morphologic abnormality) 
399547009 
 
Keratotic basal cell carcinoma (morphologic abnormality) 

403914000 
 
Superficial basal cell carcinoma (disorder) 
402537005 
 
Metastatic basal cell carcinoma (disorder) 
402516002 
 
Basal cell carcinoma of abdomen (disorder) 
399746002 
 
Basal 
cell 
carcinoma 
with 
follicular 
differentiation 
(morphologic abnormality) 
399954008 
 
Basal cell carcinoma of earlobe (disorder) 
134152008 
 
Basal cell carcinoma - morpheic (morphologic abnormality) 
400137006 
 
Basal cell carcinoma - category (morphologic abnormality) 
403918002 
 
Basal cell carcinoma of glabella (disorder) 
402500004 
 
Basal cell carcinoma of ala nasi (disorder) 
403916003 
 
 Basal cell carcinoma of forehead (disorder) 
403913006 
 
 Morpheic basal cell carcinoma (disorder) 
128634009 
 
Basaloid 
squamous 
cell 
carcinoma 
(morphologic 
abnormality) 
300025007 
 
 Excision of basal cell carcinoma (procedure) 
402528005 
 
 Basal cell carcinoma - keratotic (disorder) 
402506005 
 
Basal cell carcinoma of lower lip (disorder) 
61098004 
 
Multifocal superficial basal cell carcinoma (morphologic 
abnormality) 
402526009 
 
Basal cell carcinoma - follicular (disorder) 
402505009 
 
Basal cell carcinoma of upper lip (disorder) 
56665009 
 
Infiltrating basal cell carcinoma (morphologic abnormality) 
400071004 
 
Basal 
cell 
carcinoma, 
micronodular 
(morphologic 
abnormality) 
254701007 
 
Basal cell carcinoma of skin (disorder) 
402512000 
 
Basal cell carcinoma of antitragus (disorder) 
402517006 
 
Basal cell carcinoma of upper back (disorder) 
402518001 
 
Basal cell carcinoma of lower back (disorder) 
423535002 
 
Basal cell carcinoma of chest wall (disorder) 
402527000 
 
Basal cell carcinoma - infiltrative (disorder) 
402502007 
 
Basal cell carcinoma of tip of nose (disorder) 
402529002 
 
Basal cell carcinoma - micronodular (disorder) 
37304002 
 
Basosquamous carcinoma (morphologic abnormality) 
300026008 
 
Cryotherapy of basal cell carcinoma (procedure) 
402819001 
 
Basal cell carcinoma of skin of lip (disorder) 
402524007 
 
Basal cell carcinoma - adamantinoid (disorder) 
402497005 
 
 Basal cell carcinoma of root of nose (disorder) 
716274007 
 
Nodular basal cell carcinoma of skin (disorder) 
402494003 
 
Basal cell carcinoma of lower eyelid (disorder) 
402523001 
 
Basal cell carcinoma of truncal skin (disorder) 
80071000119103 
 
 Basal cell carcinoma of skin in situ (disorder) 
403919005 
 
Basal cell carcinoma of upper eyelid (disorder) 
43369006 
 
Basal 
cell 
carcinoma, 
fibroepithelial 
(morphologic 
abnormality) 
402510008 
 
Basal cell carcinoma of helix of ear (disorder) 
400057007 
 
Basal cell carcinoma of pinnal sulcus (disorder) 
302821007 
 
Basal cell carcinoma - sclerosing type (morphologic 
abnormality) 
403911008 
 
Nodulo-ulcerative basal cell carcinoma (disorder) 
402495002 
 
Basal cell carcinoma of medial canthus (disorder) 

402515003 
 
Basal cell carcinoma of anterior chest (disorder) 
399746002 
 
Basal 
cell 
carcinoma 
with 
follicular 
differentiation 
(morphologic abnormality) 
302821007 
 
Basal cell carcinoma - sclerosing type (morphologic 
abnormality) 
402498000 
 
 Basal cell carcinoma of dorsum of nose (disorder) 
402508006 
 
Basal cell carcinoma of chin (disorder) 
402546004 
 
Basal cell carcinoma - third recurrence (disorder) 
402532004 
 
Basal cell carcinoma with monster cells (disorder) 
428796002 
 
Excisional biopsy of basal cell carcinoma (procedure) 
402503002 
 
Basal cell carcinoma of nasal columella (disorder 
402519009 
 
Basal cell carcinoma of face (disorder) 
402544001 
 
Basal cell carcinoma - first recurrence (disorder) 
402496001 
 
Basal cell carcinoma of lateral canthus (disorder) 
402521004 
 
Basal cell carcinoma of upper extremity (disorder) 
402522006 
 
Basal cell carcinoma of lower extremity (disorder) 
403910009 
 
Circumscribed solid basal cell carcinoma (disorder) 
1079101000119100 
 
Primary basal cell carcinoma of left ear (disorder) 
402501000 
 
Basal cell carcinoma of supratip of nose (disorder) 
400174005 
 
Basal cell carcinoma of antihelix of ear (disorder) 
402514004 
 
Basal cell carcinoma of obverse of pinna (disorder) 
403913006 
 
Morpheic basal cell carcinoma (disorder) 
254702000 
 
Basosquamous carcinoma (disorder) 
69411000119107 
 
 History of basal cell carcinoma of eyelid (situation) 
1079161000119100 
 
Primary basal cell carcinoma of right ear (disorder) 
402504008 
 
Basal cell carcinoma of naolabial groove (disorder) 
428796002 
 
Excisional biopsy of basal cell carcinoma (procedure) 
403909004 
 
Pigmented basal cell carcinoma (disorder) 
399934007 
 
Basal cell carcinoma of preauricular skin (disorder) 
403916003 
 
Basal cell carcinoma of forehead (disorder) 
399897004 
 
Basal cell carcinoma of postauricular skin (disorder) 
1079111000119100 
 
Primary basal cell carcinoma of left eyelid (disorder) 
402511007 
 
Basal cell carcinoma of conchal bowl of ear (disorder) 
402500004 
 
Basal cell carcinoma of ala nasi (disorder) 
300025007 
 
Excision of basal cell carcinoma (procedure) 
1079171000119100 
 
Primary basal cell carcinoma of right eyelid (disorder) 
402534003 
 
Basal cell carcinoma with signet ring change (disorder) 
403712008 
 
Psoralen and long-wave ultraviolet radiation therapy-
associated basal cell carcinoma (disorder) 
402531006 
 
Basal cell carcinoma with granular cell change (disorder) 
80071000119103 
 
Basal cell carcinoma of skin in situ (disorder)  
402497005 
 
Basal cell carcinoma of root of nose (disorder) 
1079091000119100 
 
Primary basal cell carcinoma of left upper limb 
423325007 
 
Basal cell carcinoma of external auditory canal (disorder) 
1079131000119100 
 
Primary basal cell carcinoma of left lower limb (disorder) 
1079151000119100 
 
Primary basal cell carcinoma of right upper limb (disorder) 
1079191000119100 
 
Primary basal cell carcinoma of right lower limb (disorder) 
399470004 
 
Basal 
cell 
carcinoma 
with 
eccrine 
differentiation 
(morphologic abnormality) 

399569002 
 
Basal cell carcinoma in basal cell nevus syndrome 
(morphologic abnormality) 
43369006 
 
Basal 
cell 
carcinoma, 
fibroepithelial 
(morphologic 
abnormality) 
254710004 
 
Basal cell carcinoma with eccrine differentiation (disorder) 
399487002 
 
Basal 
cell 
carcinoma 
with 
adnexal 
differentiation 
(morphologic abnormality) 
402499008 
 
Basal cell carcinoma of lateral side wall of nose (disorder) 
402498000 
 
Basal cell carcinoma of dorsum of nose (disorder) 
402539008 
 
Basal cell carcinoma recurrent following excision (disorder) 
399958006 
 
Basal 
cell 
carcinoma 
with 
matrical 
differentiation 
(morphologic abnormality) 
402541009 
 
Basal cell carcinoma recurrent following curettage 
(disorder) 
400087001 
 
Basal cell carcinoma with sebaceous differentiation 
(morphologic abnormality) 
402545000 
 
 Basal cell carcinoma - second recurrence (disorder) 
402514004 
 
 Basal cell carcinoma of obverse of pinna (disorder) 
402542002 
 
Basal cell carcinoma recurrent following cryotherapy 
(disorder) 
816972004 
 
Basal cell carcinoma with sarcomatoid differentiation 
(morphologic abnormality) 
402543007 
 
 Basal cell carcinoma recurrent following radiotherapy 
(disorder) 
69411000119107 
 
History of basal cell carcinoma of eyelid (situation) 
402511007 
 
Basal cell carcinoma of conchal bowl of ear (disorder) 
402540005 
 
Basal cell carcinoma recurrent following Mohs' excision 
(disorder) 
703499006 
 
Excision of postauricular basal cell carcinoma with closure 
(procedure) 
402547008 
 
Basal cell carcinoma - multiple recurrences (more than 
three times) (disorder) 
736465001 
 
Excision of basal cell carcinoma from right postauricular 
region with closure (procedure) 
10149001 
 
Merkel's cell (cell) 
253001006 
 
Merkel cell carcinoma (disorder) 
5052009 
 
Merkel cell carcinoma (morphologic abnormality) 
133841000119105 
 
Merkel cell carcinoma of face (disorder) 
138141000119108 
 
History of merkel cell carcinoma (situation) 
133881000119100 
 
Merkel cell carcinoma of lower limb (disorder) 
133871000119103 
 
 Merkel cell carcinoma of upper limb (disorder) 
352071000119105 
 
Merkel cell carcinoma of left lower limb (disorder) 
351461000119100 
 
Merkel cell carcinoma of right lower limb (disorder) 
721541009 
 
Primary malignant sarcoma of skin (disorder) 
109386008 
 
Kaposi's sarcoma of skin (disorder) 
254800003 
 
Epithelioid cell sarcoma of skin (disorder) 
404093001 
 
Sarcomatous metastasis in skin (disorder) 
404155008 
 
Granulocytic sarcoma affecting skin (disorder) 
90120004 
 
Mycosis fungoides (morphologic abnormality) 
118618005 
 
Mycosis fungoides (disorder) 

765328000 
 
Classic mycosis fungoides (disorder) 
404115006 
 
Bullous mycosis fungoides (disorder) 
94714002 
 
Mycosis fungoides of spleen (disorder) 
404117003 
 
Spongiotic mycosis fungoides (disorder) 
681291000119105 
 
History of mycosis fungoides (situation) 
418628003 
 
Follicular mycosis fungoides (morphologic abnormality) 
404113004 
 
Tumour stage mycosis fungoides (disorder) 
404118008 
 
Syrngotropic mycosis fungoides (disorder) 
404112009 
 
Granulomatous mycosis fungoides (disorder) 
404114005 
 
Erythrodermic mycosis fungoides (disorder) 
404110001 
 
Hypomelanocytic mycosis fungoides (disorder) 
404109006 
 
Folliculotropic mycosis fungoides (disorder) 
404108003 
 
Pokilodermatous mycosis fungoides (disorder) 
404107008 
 
Patch/plaque stage mycosis fungoides (disorder) 
404116007 
 
Mycosis fungoides with systemic infiltration (disorder) 
94708009 
 
Mycosis fungoides of intrapelvic lymph nodes (disorder) 
94707004 
 
Mycosis fungoides of intra-abdominal lymph nodes 
(disorder) 
188627002 
 
Mycosis fungoides of  lymph nodes of multiple sites 
(disorder) 
404111002 
 
Lymphomatoid papulosis-associated mycosis fungoides 
(disorder) 
404104001 
 
Lymphomatoid papulosis type B mycosis fungoides-like 
(disorder) 
94715001 
 
Mycosis fungoides of extranodal AND/OR solid organ site 
(disorder) 
94709001 
 
Mycosis fungoides of intrathoracic lymph nodes (disorder) 
94711005 
 
Mycosis fungoides of lymph nodes of head, face AND/OR 
neck (disorder) 
94710006 
 
Mycosis fungoides of lymph nodes of axilla AND/OR upper 
limb (disorder) 
188627002 
 
Mycosis fungoides of lymph nodes of multiple sites 
(disorder) 
94712003 
 
Mycosis fungoides of lymph nodes of inguinal region 
AND/OR lower limb (disorder) 
28054005 
 
Cutaneous T-cell lymphoma, no International Classifcation 
of 
Diseases 
for 
oncology 
subtype 
(morphologic 
abnormality) 
40012207 
 
Primary cutaneous T-cell lymphoma (disorder) 
277613000 
 
Cutaneous/peripheral T-cell lymphoma (disorder) 
404128004 
 
CD-30 negative cutanoeus T-cell lymphoma (disorder) 
419283005 
 
Primary 
cutaneous 
T-cell 
lymphoma 
- 
category 
(morphologic abnormality) 
128804002 
 
Primary 
cutaneous 
CD30 
antigen 
positive 
T-cell 
lymphoproliferative disorder (morphologic abnormality) 
450908002 
 
Primary 
cutaneous 
gamma-delta 
T-cell 
lymphoma 
(morphologic abnormality) 
122571000119106 
 
History of primary cutaneous T-cell lymphoma (situation) 
419018000 
 
Primary cutaneous large T-cell lymphoma - category 
(morphologic abnormality) 

402880009 
 
Primary cutaneous large T-cell lymphoma (disorder) 
404133000 
 
Subcutaneous panniculitic cutaneous T-cell lymphoma 
(disorder) 
404128004 
 
CD-30 negative cutaneous T-cell lymphoma (disorder) 
787198005 
 
Primary cutaneous acral CD8 positive T-cell lymphoma 
(morphologic abnormality) 
397352006 
 
Primary cutaneous anaplastic large T-cell lymphoma, CD30-
positive (morphologic abnormality) 
733627006 
 
Primary cutaneous gamma-delta-positive T-cell lymphoma 
(disorder) 
404129007 
 
CD-30 negative anaplastic large T-cell cutaneous lymphoma 
(disorder) 
122571000119106 
 
History of malignant cutaneous T-cell lymphoma (situation) 
404130002 
 
CD-30 negative pleomorphic large T-cell cutaneous 
lymphoma (disorder) 
404126000 
 
CD-30 positive pleomorphic large T-cell cutaneous 
lymphoma (disorder) 
419283005 
 
Primary 
cutaneous 
T-cell 
lymphoma 
- 
category 
(morphologic abnormality) 
450908002 
 
Primary cutaneous gamma-delta T-cell lymphoma - 
category (morphologic abnormality) 
765136002 
 
Primary 
cutaneous 
CD8 
positive 
aggressicve 
epidermotropic cytotoxic T-cell lymphoma (disorder) 
128875000 
 
Primary cutaneous CD30 antigen positive large T-cell 
lymphoma (disorder) 
733895005 
 
Primary 
cutaneous 
CD8 
positive 
aggressicve 
epidermotropic cytotoxic T-cell lymphoma (morphologic 
abnormality) 
419586003 
 
Primary cutaneous T-cell lymphoma, large cell, CD30-
negative (morphological abnormality) 
118611004 
 
Sezary's disease (disorder) 
4950009 
 
Sezary's disease (morphologic abnormality) 
255101006 
 
Sezary disease of skin (disorder) 
95263006 
 
Sezary's disase of spleen (disorder) 
188632001 
 
Sezary's disase of intra-abdominal lymph nodes (disorder) 
188635004 
 
Sezary's disase of intrapelvic lymph nodes (disorder) 
188631008 
 
Sezary's disase of intrathoracic lymph nodes (disorder) 
188637007 
 
Sezary disease of lymph nodes of multiple sites (disorder) 
95264000 
 
Sézary's disease of extranodal AND/OR solid organ site 
(disorder) 
 188633006 
 
Sézary's disease of lymph nodes of axilla and upper limb 
(disorder) 
95260009 
 
Sézary's disease of lymph nodes of head, face AND/OR neck 
(disorder) 
188634000 
 
Sézary's disease of lymph nodes of inguinal region and 
lower limb (disorder) 
95261008 
 
Sézary's disease of lymph nodes of inguinal region AND/OR 
lower limb (disorder) 
419392005 
 
Primary cutaneous lymphoma (morphologic abnormality)