Pathophysiological Mechanisms Elicited by Ischemia and Metabolic Co-morbidities in Myocardium of Patients With Coronary Artery Disease
Conditions: Coronary Artery Disease, Diabetes Mellitus, Mitochondrial Metabolism Disorders
Sponsor: University of Split, School of Medicine

Official title of the study: 
 
Pathophysiological Mechanisms Elicited by Ischemia and Metabolic Co-morbidities in 
Myocardium of Patients with Coronary Artery Disease 
 
 
 
NCT number: 
NCT03179137 
 
 
Document date: 
June 16, 2020 
 
 
 
Participating institutions: 
University of Split School of Medicine 
University Hospital of Split 
 
 
 
 
 
 
 
 
 
 
 
 
 

STUDY PROTOCOL 
 
Study location: Clinic for Cardiovascular diseases and Department of Cardiac Surgery, 
University Hospital of Split 
Ethical Approval: This study protocol had been reviewed and approved by the Ethics 
Committees of the University of Split School of Medicine and University Hospital of Split.  
Patient recruitment: All patients fulfilling the inclusion criteria will receive a printed 
material containing information regarding the study and any potential questions will be 
answered by the recruiting personnel. A signed informed consent form will be a prerequisite 
for patient inclusion into the study. 
Study protocol: 
 
 
 
Patients undergoing 
coronary angiography 
Inclusion criteria 
Exclusion criteria 
Signed informed 
consent 
Total number of 
participants 
N=90 
Measurements: 
1. Basic anthropometry 
2. Medical history and physical examination 
3. Transthoracic echocardiography 
4. Analysis of peripheral blood 
5. Analysis of coronary angiography (SYNTAX 
score, Rentrop score) 
6. Myocardial needle biopsy: analysis of 
mitochondrial and cellular parameters 
Data analysis 
Results