PRP Group & Control Group in Poseidon Poor Responders
Phase: NA
Conditions: Poor Ovarian Reserve, Platelet Derived Growth Factor
Sponsor: Karbala University

Abstract 
Background: Poor ovarian responders (POR) women represent a challenge issue in assisted 
reproduction techniques (ART). As an effort to optimize conception rates in these patients, 
ovarian platelet-rich-plasma (PRP) injection prior to intracytoplasmic sperm injection (ICSI) 
cycles has been advised to improve both the quantity and quality of oocytes and embryos, owing 
to its regenerative properties for ovarian milieu ultimately improved ART outcomes.  
Objective : This study aims to evaluate the impact of ovarian PRP therapy compared to control 
in Poseidon POR females undergoing ICSI cycles. 
 Material and Methods: A randomized controlled trial was conducted from Jan 2024 to Feb 
2025, involving 102 Poseidon POR women, Participants were divided into a PRP group (n=50), 
who received ovarian PRP injections and a control group (n=52), who received no PRP. All 
participants underwent ICSI cycles, embryological and pregnancy outcomes were compared 
between both groups within each Poseidon group. 
Results: metaphase II (MII) oocytes count showed increment in the PRP group compared to 
controls (p value=0.036). However, the mean number of MII oocytes remained comparable in 
both groups respectively (3.8±2.6 vs 4.2±1.8). Alongside, no significant differences in 
embryological outcomes or pregnancy rates were noticed in PRP and control patients among all 
Poseidon groups (all p value>0.05).  
Conclusion: Although ovarian PRP might increase MII oocytes count in Poseidon POR women 
underwent ICSI cycles. When compared to control, it does not provide significant benefits for 
oocyte and embryo parameters, nor does it improve pregnancy rates in these women.