Cerebrovascular Dysregulation in Chronic Kidney Disease
Phase: NA
Conditions: Chronic Kidney Diseases
Sponsor: University of North Texas, Denton, TX

Study Title: Cerebrovascular Dysregulation in Chronic Kidney Disease 
NCT # NCT05571605 
Upload Date: 7/1/2025 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Study Protocol:  
Objective: To evaluate the effects of 12-weeks of aerobic exercise training vs stretching 
(control group) on dynamic cerebral autoregulation in participants with chronic kidney 
disease (CKD) stages III-IV. 
Design: This study was a randomized controlled trial. Participants with CKD stages III-IV 
were enrolled for participation. All participants underwent a baseline assessment of Mean 
arterial pressure-Middle cerebral artery blood velocity very low frequency phase (radians) 
and gain (cm/s/mmHg). Participants were then randomized to a 12-week training 
intervention consisting of either aerobic exercise training or stretching (active control). The 
assessment of dynamic cerebral autoregulation was then repeated following the 
intervention.  
Methods: Mean arterial pressure-Middle cerebral artery blood velocity very low frequency 
phase (radians) and gain (cm/s/mmHg) were measured during repeated bouts of sit to 
stand at 0.05Hz. Mean arterial pressure was measured via ﬁnger photoplethysmography. 
Middle cerebral artery blood velocity was measured via transcranial Doppler ultrasound. A 
transfer function analysis was performed to derive mean arterial pressure-middle cerebral 
artery blood velocity very low frequency phase (radians) and gain (cm/s/mmHg). 
 Location: University of North Texas in Denton, TX. 
Statistical Analysis Plan:  
A two-way repeated measures ANOVA (time x group was used to compare Mean arterial 
pressure-Middle cerebral artery blood velocity very low frequency phase (radians) and gain 
(cm/s/mmHg) between time points (pre vs post) and between groups (exercise vs 
stretching).