Comparing Different Rehabilitation Exercise Strategies for Improving Arm Recovery After Stroke
Phase: NA
Conditions: Stroke
Sponsor: University of California, Irvine

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
1/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
2/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
3/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
4/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
5/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
6/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
7/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
8/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
9/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
10/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
11/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
12/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
13/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
14/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
15/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
16/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
17/89




8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
18/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
19/89


8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
20/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
21/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
22/89



8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
23/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
24/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
25/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
26/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
27/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
28/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
29/89

1. Ma VY, Chan L, Carruthers KJ. Incidence, Prevalence, Costs, and Impact on Disability of
Common Conditions Requiring Rehabilitation in the United States: Stroke, Spinal Cord Injury,
Traumatic Brain Injury, Multiple Sclerosis, Osteoarthritis, Rheumatoid Arthritis, Limb Loss, and
Back Pa. Arch Phys Med Rehabil. 2014;95(5):986-995.e1. doi:10.1016/j.apmr.2013.10.032
2. Heller A, Wade DT, Wood VA, Sunderland A, Hewer RL, Ward E. Arm function after stroke:
measurement and recovery over the first three months. J Neurol Neurosurg Psychiatry.
1987;50(6):714-719.
3. Dobkin BH. Neurologic Rehabilitation. Philadelphia: F.A. Davis Company; 1996.
4. Lohse KR, Lang CE, Boyd LA. Is more better? Using metadata to explore dose-response
relationships in stroke rehabilitation. Stroke. 2014;45(7):2053-2058.
doi:10.1161/STROKEAHA.114.004695
5. Lang CE, Macdonald JR, Reisman DS, et al. Observation of amounts of movement practice
provided during stroke rehabilitation. Arch Phys Med Rehabil. 2009;90(10):1692-1698.
doi:10.1016/j.apmr.2009.04.005
6. Jeffers MS, Karthikeyan S, Gomez-Smith M, et al. Does Stroke Rehabilitation Really Matter?
Part B: An Algorithm for Prescribing an Effective Intensity of Rehabilitation. Neurorehabil Neural
Repair. 2018;32(1):73-83. doi:10.1177/1545968317753074
7. Feys HM, De Weerdt WJ, Selz BE, et al. Effect of a therapeutic intervention for the hemiplegic
upper limb in the acute phase after stroke: a single-blind, randomized, controlled multicenter
trial. Stroke. 1998;29(4):785-792.
8. Feys H, De Weerdt W, Verbeke G, et al. Early and repetitive stimulation of the arm can
substantially improve the long-term outcome after stroke: a 5-year follow-up study of a
randomized trial. Stroke. 2004;35(4):924-929. doi:10.1161/01.STR.0000121645.44752.f7
9. Zondervan DK, Augsburger R, Bodenhoefer B, Friedman N, Reinkensmeyer DJ, Cramer SC.
Machine-Based, Self-guided Home Therapy for Individuals With Severe Arm Impairment After
Stroke: A Randomized Controlled Trial. Neurorehabil Neural Repair. 2015;29(5):395-406.
doi:10.1177/1545968314550368
10
. Smith B, Zondervan D, Lord TJ, Chan V, Reinkensmeyer D. Feasibility of a bimanual, lever-
driven wheelchair for people with severe arm impairment after stroke. In: Intl. Conf. of the IEEE
Engineering in Medicine and Biology Society. Vol 2014. ; 2014.
doi:10.1109/EMBC.2014.6944820
8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
30/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
31/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
32/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
33/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
34/89

→
8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
35/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
36/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
37/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
38/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
39/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
40/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
41/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
42/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
43/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
44/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
45/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
46/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
47/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
48/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
49/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
50/89

• An Do, M.D., has experience in human subjects' research in stroke rehabilitation
• David Reinkensmeyer, PhD, has experience in human subjects' research in the areas of
biomechanics, neural control of movement, and rehabilitation.
• Vicky Chan PT,DPT, is a licensed Physical Therapist with over 20 years' experience in stroke
rehabilitation treatment and research.
• Alison McKenzie, PT, DPT, PhD, is a professor at the Department of Physical Therapy at
Chapman University. She has over 25 years' experience in stroke rehabilitation treatment and
research.
8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
51/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
52/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
53/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
54/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
55/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
56/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
57/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
58/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
59/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
60/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
61/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
62/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
63/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
64/89

• Repetitive movement exercise may cause muscular fatigue (make the subject’s muscles feel
tired), muscle soreness, joint soreness, or arm pain. The subject will be instructed to cease
exercise and consult the supervising therapist and physician if any pain arises from the
exercise.
• There is a small risk of having the subject’s fingers or hand or arm pinched or bruised by the
device. The subject will be trained on how to use the device appropriately to avoid this risk.
• There is a risk of a breach of privacy if someone unrelated to the study obtains the videotapes
of the subject, but the study investigators will protect against this risk by storing the tapes in a
locked cabinet with a coded identifier. The subject will be asked for consent if the investigators
wish to use any of the videotapes for publication or presentation of the study.
• Unknown risks: There may be risks related to the research that we don't know about yet.
However, the subject will be informed of any additional risks to which he or she may be
exposed, and any changes that are made to the study, as a result of any newly-identified risks.
8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
65/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
66/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
67/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
68/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
69/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
70/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
71/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
72/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
73/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
74/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
75/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
76/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
77/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
78/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
79/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
80/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
81/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
82/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
83/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
84/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
85/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
86/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
87/89

	
	
8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
88/89

8/21/25, 11:01 PM
Protocols
https://uci.kuali.co/protocols/protocols/67cf75939c5c218eec5dc547/print
89/89