National Longitudinal Cohort of Hematological Diseases (NICHE)
Conditions: Multiple Myeloma, Acute Myeloid Leukemia, Hemophilia, Hemophilia A, Hemophilia B, Myelodysplastic Syndrome, MDS, Lymphoma, Leukemia, Aplastic Anemia, Bleeding Disorder, Bone Marrow Transplantation, Blood Disease Infection, Autoimmune Hemolytic Anemia, AIHA, Essential Thrombocythemia, ET, Large Granular Lymphocyte Leukemia, LGLL, Paroxysmal Nocturnal Hemoglobinuria, PNH
Sponsor: Institute of Hematology & Blood Diseases Hospital, China

National Longitudinal Cohort of Hematological Diseases 
- Hemophilia  
(NICHE- Hemophilia) 
 
 
 
 
 
 
 
 
Applicant：Institute of Hematology & Blood Diseases Hospital
Version：2.0
Date：27-Aug-2020 
 
 

National Longitudinal Cohort of Hematological Diseases-Hemophilia (NICHE-
Hemophilia) 
 
Background 
Hematological diseases are disorders of the blood and hematopoietic organs. The 
current hematological cohorts are mostly based on single-center or multi-center cases, 
or cohorts with limited sample size in China. There is a lack of comprehensive and 
large-scale prospective cohort studies in hematology.  
 
Objectives 
The objectives of this study is to investigate the incidence and risk factors of 
Hemophilia, and to analyze the treatment methods, prognosis and medical expenses of 
these patients in China. 
 
Subjects 
Patients who were diagnosed with Hemophilia in the investigating hospitals from 
January 1, 2020. 
 
Method 
The NICHE-Hemophilia will collect basic information, diagnostic and treatment 
information, as well as medical expense information of patients from medical records. 
The study will use questionnaire to measure the exposure of patients, and prospectively 
follow-up to collect the prognosis information.