The Effects of Ankaferd Hemostat on Preventing Oral Mucositis in Colorectal Cancer Patients Receiving Chemotherapy
Phase: NA
Conditions: Colon Cancer, Oral Mucositis, Nurse's Role, Chemotherapy Effect
Sponsor: Uludag University

                                                                                                                              6.02.2023 
Clinical Trial No: NCT05438771 
 
The Effects of Ankaferd Hemostat on Preventing Oral Mucositis in Colorectal Cancer 
Patients Receiving Chemotherapy 
Introduction: The purpose of oral care is to reduce the effect of oral microbial flora and prevent 
infection, pain, and bleeding associated with cancer treatment. New agents are introduced each 
day to be used in the prevention and treatment of mucositis in cancer treatment. One of those 
agents is the Ankaferd hemostat. Ankaferd hemostat has pleiotropic effects and anti-infective 
characteristics in tissue healing. The purpose of this study is to evaluate the effectiveness of the 
Ankaferd hemostat in the prevention of oral mucositis due to chemotherapy in adult patients 
diagnosed with colorectal cancer. 
Material and Method: The study was designed as a randomized controlled experimental study 
to be conducted with patients who are recently diagnosed with colorectal cancer and will receive 
the first course of chemotherapy.  Data were collected using the Performance Score and the 
Oral Mucositis Evaluation Scale. 
Findings: There is a significant difference in the mucositis symptoms on days 7 and 15 after 
chemotherapy in the ankaferd hemostat and the bicarbonate group (p<0.05). In the binary 
logistic regression analysis, among the factors affecting the formation of mucositis on day 7, 
only neutrophil and TSH were included in the model, while only the TSH variable is statistically 
significant. 
Discussion and Conclusion:  A lower level of mucositis was found in the study compared to 
the other agents in the literature. It was determined that Ankaferd emostat is effective in 
preventing oral mucositis due to chemotherapy in adult patients diagnosed with colorectal 
cancer.