External Comparison of Effectiveness of Ibalizumab in Clinical Trials vs. Other HTE Regimens in OPERA
Conditions: HIV-1-infection
Sponsor: Epividian

 

 
Epividian, inc. 
 Page 1 of 30  
 
 

 
Epividian, inc. 
 Page 2 of 30  
 
 
 
 
 
 
 

 
Epividian, inc. 
 Page 3 of 30  

 
Epividian, inc. 
 Page 4 of 30  

 
Epividian, inc. 
 Page 5 of 30  
 

 
Epividian, inc. 
 Page 6 of 30  
 

 
Epividian, inc. 
 Page 7 of 30  
 

 
Epividian, inc. 
 Page 8 of 30  
 
 
• 
• 
• 
• 
 
 
• 
• 
• 
• 

 
Epividian, inc. 
 Page 9 of 30  
 
 
 

 
Epividian, inc. 
 Page 10 of 30  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 
Epividian, inc. 
 Page 11 of 30  
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 
Epividian, inc. 
 Page 12 of 30  
 
 
 
 
 
 
 
 
 
 
 
 
≥
 
 
 
 
 
 

 
Epividian, inc. 
 Page 13 of 30  
 
 
• 
• 
• 
 
 
 
 ≥
 
• 
• 
• 
• 
• 
• 
 

 
Epividian, inc. 
 Page 14 of 30  
• 
• 
 
▪ 
▪ 
▪ 
▪ 
▪ 
▪ 
▪ 
 
 
 
 
• 

 
Epividian, inc. 
 Page 15 of 30  
 
 
 
• 
• 
 
• 
• 
• 
• 

 
Epividian, inc. 
 Page 16 of 30  
• 
• 
• 
• 
o 
o 
o 
𝑊𝑒𝑖𝑔ℎ𝑡 = ∑𝐴𝑅𝑉𝑛× (5 −𝑅𝐿)
5
𝑛
1
+ 𝐷𝑅𝑉× (4 −𝑅𝐿)
4
 
 

 
Epividian, inc. 
 Page 17 of 30  
 

 
Epividian, inc. 
 Page 18 of 30  
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
• 
 
 

 
Epividian, inc. 
 Page 19 of 30  
 
 

 
Epividian, inc. 
 Page 20 of 30  
 

 
Epividian, inc. 
 Page 21 of 30  
 
 
 
 

 
Epividian, inc. 
 Page 22 of 30  
 

 
Epividian, inc. 
 Page 23 of 30  
 
 
 

 
Epividian, inc. 
 Page 24 of 30  
 

 
Epividian, inc. 
 Page 25 of 30  
 
 

 
Epividian, inc. 
 Page 26 of 30  
 

 
Epividian, inc. 
 Page 27 of 30  

 
Epividian, inc. 
 Page 28 of 30  

 
Epividian, inc. 
 Page 29 of 30