Effects of Positive End-Expiratory Pressure Levels on Lung Recruitment Duration and Hemodynamics After Alveolar Recruitment Maneuver: A Randomized Clinical Trial
Phase: NA
Conditions: Dynamic Lung Compliance, Alveolar Recruitment Maneuver
Sponsor: Northern Jiangsu People's Hospital

The Influence of Different PEEP Levels After Recruitment Maneuvre on the Effect
of Alveolar Recruitment Maintenance and Patients’ Cardiac Function
Study Protocol
1. Demographic Data
Name：
Gender：
Age：
Height(cm)：
Weight(kg)：
BMI：
Hospitalization Number：
Ward:
Bed Number：
2. Clinical Data
Department：
Diagnosis：
Surgical Procedure Name：
ASA Classification:
Associated Underlying Conditions：
Duration of surgery（min）：
Intraoperative crystalloids（ml）:
Intraoperative colloids（ml）:
Intraoperative urine output（ml）
Intraoperative blood loss（ml）:
Intraoperative norepinephrine dose（ug）:
3. Study Implementation
Group A ：PEEP=0
cmH20 ，Group B：PEEP=4 cmH20 ，Group C ：PEEP=8 cmH20
，
Group D：PEEP=12 cmH20）
Patient admission vital signs(SpO2
、NBP
、HR
），invasive
arterial pressure monitoring
anesthesia
induction
Pre-oxygenation was performed with pure oxygen for 3 minutes
followed by endotracheal intubation
Endotracheal
intubation
ventilation parameters: VT 6-8ml/kg ，FiO2 60% ，PEEP 4 cmH2O
，I/E 1 ：2.
T0
baseline
respiratory
mechanics
parameters
(Cdyn
,DP
,
low
point
inflection
of
P-V
loop
,
Petco2
,
Ppeak
, Pplat
)
baseline
hemodynamic
variables
(MAP
,
PR
,
SV
,
CO
, CI
)
ARM
ARM was performed at a pressure of 30 cmH2O for 30 seconds.
After ARM, immediately set different PEEP values according to
group settings
T1
RM 1minDP
、Cdyn
、MAP
、PR
、SV
、CO
、CI
T2
RM 2minDP
、Cdyn
、MAP
、PR
、SV
、CO
、CI
T3
RM 3minDP
、Cdyn
、MAP
、PR
、SV
、CO
、CI
T4
RM 4minDP
、Cdyn
、MAP
、PR
、SV
、CO
、CI
T5
RM 5minDP
、Cdyn
、MAP
、PR
、SV
、CO
、CI
T6
RM 10minDP
、Cdyn
、MAP
、PR
、SV
、CO
、CI
T7
RM 15minDP
、Cdyn
、MAP
、PR
、SV
、CO
、CI
T8
RM 20minDP
、Cdyn
、MAP
、PR
、SV
、CO
、CI
T9
RM 25minDP
、Cdyn
、MAP
、PR
、SV
、CO
、CI
T10
RM 30minDP
、Cdyn
、MAP
、PR
、SV
、CO
、CI

T11
RM 35minDP
、Cdyn
、MAP
、PR
、SV
、CO
、CI
T12
RM 40minDP
、Cdyn
、MAP
、PR
、SV
、CO
、CI
2025.11.30
Statistical analysis was performed with SPSS v. 27.0. Data are expressed as number of
events (percentage) or means
±
standard deviation, as appropriate. Intra-group
comparison was performed using paired-sample t-test, and comparison among groups
used one-way analysis of variance. Figures were prepared with GraphPad Prism
(GraphPad Software, La Jolla, CA USA). P < 0.05 was considered as statistically
significant.

the time required for Cdyn to return to
baseline after ARM:
PEEP was adjusted to 4 cmH2O and was maintained at this level until
the end of surgery.