Synergistic Effect of Vitamin E & D in Reducing the Risk of Effects Associated With Atypical Antipsychotics
Phase: NA
Conditions: Antipsychotics and Neuroleptics Toxicity
Sponsor: Dr Rabia Arshad

 
 
 
 
 
Dated: 12 Dec 2019 
COVER LETTER 
We are writing to apply for NTC number for our project titled: 
“Synergistic effect of Vitamin E and Vitamin D in reducing risk of side effects associated 
typical anti-psychotics and improvement of psychiatric illness” 
This particular research was designed as severe mental stress and psychotic illness are becoming 
alarming and treatment therapy induces serious side effects like weight gain, change in lipid profile 
and high blood pressure etc. There are severe side effects associated with atypical antipsychotics, 
especially with widely used olanzapine, quetiapine and risperidone. Vitamin D and Vitamin E are 
well known for their anti-oxidant activity. In our study we have emphasized the synergistic effects 
of Vit D and Vit E administered with atypical anti psychotics in reducing the side effects and to 
evaluate the improvement in the disease. For evaluation, Serum glutathione peroxidase (GPx) and 
super oxide dismutase (SOD) were examined by colorimetric method. Tumor necrosis factor alpha 
(TNF-α) and interferon-γ levels were analyzed by PCR whereas serum lipid profile was assessed 
by commercially available kits. Improvement in illness was measured through Positive and 
Negative Syndrome Scale score (PANSS) 
We are in process of this clinical trial registration and would be happy to hear a positive 
response.  
 
Regards 
Dr. M. Abid 
Dr. Rabia Arshad