Study on the Correlation Between Treg Immune Cells on the Muscle Content and Cognitive Functions of the Elderly
Conditions: Cognitive Disorder Patients and Cognitive Assessment
Sponsor: Fifth Affiliated Hospital, Sun Yat-Sen University

Study on the Correlation Between Treg Immune Cells on the Muscle Content and Cognitive Functions of the Elderly
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版本日期：2023-08-16
Clinical Research Abstract
Brief Title
Study on the Correlation Between Treg Immune Cells on the Muscle
Content and Cognitive Functions of the Elderly
ID
ZDWY.LNBK.007
Sponsor
Fifth Affiliated Hospital, Sun Yat-Sen University
Research unit
Fifth Affiliated Hospital, Sun Yat-Sen University
Main researcher
Wenya Han
Statistical unit and
person in charge of
statistics
Fifth Affiliated Hospital, Sun Yat-Sen University
Wenya Han
Research purposes
In order to explore the impact of the level of the elderly TREG immune
cells and the effects of different fat distribution and muscle content, the
impact of the level of TREG immune cells on cognitive functions is
explored. The correlation between visceral fat content, subcutaneous fat
content and cognitive function.
Sample size
100
Study Type
Observational
Selected standards
for subjects
Inclusion criteria：
1. 40-90 years old
Exclusion criteria：
previous diagnosis of dementia (including Alzheimer's disease, Lewy
body dementia, Parkinson's disease, or other dementias) were
excluded.
Research step
1. Collect 2023-05-01 to 2024-12-31 Elderly patients who are consulting
in our hospital at the same time improve the data measurement and TREG
cell measurement data at the same time; 2. The level of TREG immune
cells and different fat distribution and muscle content Impact; 3. The
impact of the level of TREG immune cells on cognitive function; 4.

Study on the Correlation Between Treg Immune Cells on the Muscle Content and Cognitive Functions of the Elderly
版本号：V1.0
第2页/共2页
版本日期：2023-08-16
Evaluate the effects of different fat distribution and muscle content on
cognitive functions, evaluate the correlation between internal organs,
subcutaneous fat content and cognitive functions; 5. Write the paper.
Terminal indicator
Cognitive function decline
Statistical Analysis
Use a linear regression model to analyze the level of the level of TREG
immune cells, the effects of different fat distribution and muscle content;
the impact of the level of TREG immune cells on the level of TREG
immune cells is analyzed by the Mann-Whitney U test; the evaluation of
different fat distribution and muscle content The impact on cognitive
functions, evaluate the correlation between the content of visceral fat,
subcutaneous fat content and cognitive functions.
Statistical software includes SPSS27 and Graphpad Prism 8. Inspection
level α = 0.05.