Role of Intraoperative Biomarkers in Prognosis of Perioperative Complications in Reconstructive Thoracic Aorta Surgery
Phase: NA
Conditions: Aortic Aneurysm, Thoracoabdominal Aneurysm, Aortic Dissection, Complication
Sponsor: Petrovsky National Research Centre of Surgery

Assessing the significance of some biomarkers in perioperative period after 
thoracic aortic reconstruction 
NCT04689139 Protocol ID039420200002 
Date 22.12.2020 
Objective. This study aims to assess the association between levels of biomarkers 
and postoperative complications in patients after thoracic and thoracoabdominal 
aortic reconstruction. 
Design. Single group assessment observational open label study.  
Methods. The study protocol approved by the Ethics Committee. Patients 
included: ascending aortic and aortic arch reconstruction. 
Eligibility. Age 18-75 years. Inclusion Criteria: Elective thoracic and 
thoracoabdominal surgery. Exclusion Criteria: Hemolysis in blood sample. 
The concentrations of proadrenomedullin, procalcitonin, presepsin, procalcitonin, 
troponin I and N-terminal brain natriuretic peptide measurement before induction 
anesthesia, at the end of the surgical operation and in 6 hours after surgery. 
Turnaround time test no more than 40 minutes. The concentrations of 
procalcitonin and proadrenomedullin determined on a Kryptor Compact Plus 
analyzer (Thermo Fisher Scientific), troponin I, NT-proBNP and presepsin on a 
PATHFAST analyzer (LSI Medience Corporation). 
Statistical analysis. The normality of the distribution estimated by chi square. The 
data analyzed with a non-parametric test (Mann–Whitney U-test) and Student t-
test according to normality tests. A P value ≤0.05 considered to be statistically 
significant. ROC-analysis to identify the predictors of postoperative complications 
and regression coefficients for odds ratio calculation for each dependent variable. 
Regression analysis to assess the influence on quantitative variables of 
biomarkers.