Randomized Trial to Test the Effect of Rivaroxaban or Apixaban on Menstrual Blood Loss in Women
Phase: PHASE2
Conditions: Venous Thromboembolism, Menstruation
Sponsor: Indiana University

V02.09.2021 
Randomized Trial to Test the Effect of Rivaroxaban or Apixaban on Menstrual Blood 
Loss in WomEn (RAMBLE) 
 
NCT02829957 
 
The primary comparison is the frequency of study-defined abnormal uterine bleeding between women 
treated with apixaban, versus women treated with rivaroxaban. The plan was to compare these 
frequencies using 95% confidence intervals for the difference in proportions.