A Multicentre, Single-arm, Phase 3b Efficacy and Safety Study of Tezepelumab 210 mg Administered Subcutaneously to Reduce Oral Corticosteroid Use in Adult Participants With Severe Asthma on High-dose Inhaled Corticosteroid Plus Long-acting β2 Agonist and Long-term Oral Corticosteroid Therapy (WAYFINDER)
Phase: PHASE3
Conditions: Asthma
Sponsor: AstraZeneca

Document Type:  
Final Protocol 
Document Date:  
10 November 2022 
Study Title:  
A Multicentre, Single-arm, Phase 3b Efficacy and Safety Study of 
Tezepelumab 210 mg Administered Subcutaneously to Reduce Oral 
Corticosteroid Use in Adult Participants with Severe Asthma on 
High-dose Inhaled Corticosteroid plus Long-acting ȕ2 Agonist and 
Long-term Oral Corticosteroid Therapy (WAYFINDER) 
Protocol Reference Number: D5180C00037 
NCT Number:  
 NCT05274815 
 
 

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APPENDIX D (67,0$7('
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APPENDIX E 35('1,621(35('1,62/21('26(60*,15(/$7,2172
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APPENDIX G $1$3+</$;,66,*166<037206$1'0$1$*(0(17
APPENDIX H +$1'/,1*2)+80$1%,2/2*,&$/6$03/(6
APPENDIX I (67,0$7(''$,/<'26(6)25,1+$/('&257,&267(52,'6
APPENDIX J $'5(1$/&5,6,6*8,'(/,1(6
APPENDIX K 0(',&$/ '(9,&( $(6 $'(6 6$(6 6$'(6 86$'(6 $1'
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Appendix C
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Appendix D
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Appendix E
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Appendix F
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Appendix G
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Appendix I
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Appendix J
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SIGNATURE PAGE
This is a representation of an electronic record that was signed
electronically and this page is the manifestation of the electronic signature
Document Name: d5180c00037-csp-v3
Document Title:
D5180C00037 Clinical Study Protocol version 3
Document ID:
Doc ID-004701434
Version Label:
3.0 CURRENT LATEST APPROVED
Server Date
(dd-MMM-yyyy HH:mm ‘UTC’Z)
Signed by
Meaning of Signature
23-Nov-2022 17:05 UTC
Content Approval
22-Nov-2022 14:32 UTC
Management Approval
Notes: (1) Document details as stored in ANGEL, an AstraZeneca document management system.
PPD
PPD