Effect of Aerobic Exercises on Immune System in Patients With Multiple Sclerosis
Phase: NA
Conditions: Multiple Sclerosis, Primary Progressive
Sponsor: South Valley University

 
Official Title of Study: -  
 
Effect of aerobic exercises on immune 
system in patients with multiple sclerosis  
 
 
 
 
Document Date: - 08/30/2020.  
 
 
 
 
 
 
 
Human Subjects protection review board 
approval date: - 4/10/2015 
 
 
 
 
 
 

Effect of aerobic exercises on immune system in 
patients with multiple sclerosis  
 
 
 
PURPOSE:  
This study will aimed to determine the effect of aerobic exercises on the 
immune system anti inflammatory (IL-10) and pro inflammatory (IL-17) 
cytokines  and its consequences on the  functional status in the Multiple 
Sclerosis patients. 
 
 
 
 
BACKGROUND: 
Multiple sclerosis (MS) is a condition that can affect the brain and spinal 
cord, causing a wide range of potential symptoms, including problems 
with vision, arm or leg movement, sensation or balance. 
It's a lifelong condition that can sometimes cause serious disability, 
although it can occasionally be mild. In many cases, it's possible to treat 
symptoms. Average life expectancy is slightly reduced for people with 
MS. It's most commonly diagnosed in people in their 20s and 30s, 
although it can develop at any age. It's about 2 to 3 times more common 
in women than men. 
Multiple sclerosis (MS) can cause a wide range of symptoms and affect 
any part of the body. Each person with the condition is affected 
differently. 
The symptoms are unpredictable. Some people's symptoms develop and 
worsen steadily over time, while for others they come and go. Periods 
when symptoms get worse are known as relapses. Periods when 
symptoms improve or disappear are known as remissions. 
Multiple sclerosis is considered to be an immune-mediated disease in 
which the body's immune system attacks the central nervous system 
(CNS). Most MS experts believe it to be an autoimmune disease, 
although no specific antigens (proteins that stimulate the immune system) 
have been identified in MS. 

HYPOTHESES: 
H0 there is no significance difference of aerobic exercises on the immune 
system anti inflammatory (IL-10) and pro inflammatory (IL-17) cytokines   
H1 there is a significance difference of aerobic exercises on the immune 
system anti inflammatory (IL-10) and pro inflammatory (IL-17) cytokines   
 
RESEARCH QUESTION: 
Is there is significance difference of aerobic exercises on the immune 
system anti inflammatory (IL-10) and pro inflammatory (IL-17) 
cytokines?   
Aim of the study: 
To determine the effect of aerobic exercises on the immune system anti 
inflammatory (IL-10) and pro inflammatory (IL-17) cytokines  and its 
consequences on the  functional status in the Multiple Sclerosis patients. 
Inclusion criteria: 
included with age ranged from 25 to 45 years. All the patients were 
remitting relapsing MS according to revised McDonald criteria 
All patients were able to  ambulate with EDSS  for each patient ranged   
between 1.0 and 4.5  
Exclusion criteria: 
Patients with  other neurological deficits. 
psychiatric disease, history of previous  inflammatory diseases 
cardiovascular or pulmonary diseases. 
Methods for assessment: 
Blood sample testing for serum anti inflammatory cytokine  IL-10 and 
pro inflammatory cytokine IL-17. This analysis performed pre and post 3 
months of intervention. 

Methods for treatment: 
The study group (GA) : received modifying drug (interferon beta-1a) 
"Rebif" in addition to aerobic exercise. 
The control group (GB) was treated by the  disease modifying drug 
(interferon beta-1a) "Rebif".   
RECRUITMENT 
Please state clearly how the participants will be identified, 
approached and recruited.  
 
Note: Attach a copy of any poster(s), advertisement(s) or letter(s) to 
be used for recruitment. 
 
The patients will be recruited from Outpatient Clinic of faculty of medicine, 
South Vally University
 
CONSENT 
  
Describe the process that the investigator(s) will be using to obtain valid 
consent.  If consent is not to be obtained explain why. If the participants 
are minors or for other reasons are not competent to consent, describe the 
proposed alternate source of consent, including any permission / 
information letter to be provided to the person(s) providing the consent. 
 
I am                              freely and voluntarily consent to participate in a 
research program under the direction of M.Sc. 
A thorough description of the procedure has been explained and I understand 
that I may withdraw my consent and discontinue participation in this research 
at any time without prejudice to me. 
Date                                   Participant