A Multi-center Registry for Clinical Information and 99mTc-pyrophosphate Scintigraphy in Patients With Suspected Cardiac Amyloidosis in Taiwan
Conditions: Heart Failure, Cardiac Amyloidosis
Sponsor: Far Eastern Memorial Hospital

A Multi-center Cardiac PYP Scan Registry in Taiwan 
NCT05593679 
Date 2023-12-31 
 
Objectives: 
This multi-center registry will collect the key cardiovascular data elements and set up 
PYP imaging database in Taiwan.  
 
Goal 1: To standardize the imaging acquisition, analysis, interpretation and reporting.  
 
Goal 2: To compare the clinical information and PYP imaging parameters in patients 
with suspected CA, to understand the real-world data in Taiwan.  
 
Target Audience 
Every nuclear medicine department that performs PYP scan for cardiac amyloidosis 
 
Project Design and Methods 
The investigators will retrospectively and prospectively collect total 1,000 PYP 
scans that had been performed on suspected or diagnosed ATTR-CM patients in 
Taiwan and follow-up at least 1 year. All patients are enrolled based on clinical 
suspicions such as “red-flag” signs using ultrasound, NT-pro BNP and clinical data 
according to the diagnostic algorithms. Due to the diverse consensus or guidelines’ 
recommendations, some physicians may arrange PYP scans before AL exclusion. In 
patients with Grade 2 and 3 PYP myocardial uptake, genetic testing is arranged, 
serum and urine AL tests results should be confirmed. All the clinical information 
including demographic data, lab, echocardiography, or other cardiac imaging (ex. 
MRI) will be collected. The clinical information, genetic testing and imaging 
parameters derived from PYP scans (visual scores, and H/CL ratios) will be analyzed 
and compared by t-test or ANOVA based on clinical diagnosis and PYP grades.