Effect of Transversus Abdominis Plane Block Combined With General Anesthesia on Perioperative Stress Response in Patients Undergoing Radical Gastrectomy: A Double-blind Randomized Controlled Study.
Phase: NA
Conditions: Gastrostomy
Sponsor: Jilin University

 
 
 
Effect of transversus abdominis 
plane block combined with general 
anesthesia on perioperative stress 
response in patients undergoing 
radical gastrectomy 
 
NCT number: NCT03035916 
2017.1.30 
 
 
 
 
 
 
 
 
 
 

Clinical research protocol 
 
TITLE: Effect of transversus abdominis plane block 
combined with general anesthesia on perioperative stress 
response in patients undergoing radical gastrectomy. 
BACKGROUND: Postoperative pain , especially the 
incision pain, play an essential role on body stress. T6-L1 
Nerve, walking in the abdominal transverse plane (TAP), 
were block by TAP block with long-acting local anesthetic, 
which could effectively suppress abdominal pain, 
strengthen the analgesic effect, reduce the amount of 
drugs, reduce the body stress response, accelerate 
postoperative rehabilitation. Rafi in 2001 proposed blind 
TAP block through the Petit triangle, which has been 
confirmed by McDonnell et al. Subsequently, Tran 
performed TAP block by the side of the axillary line, but it 
can only affect the T10-L1 nerve. Recently，
ultrasound-guided lateral TAP block is used in the 
postoperative analgesia of lower abdominal surgery and 
has achieved satisfactory results.  
SIGNIFICANCE: Plane transverse obstruction is a new 

analgesic technique. Traditional epidural block analgesia is 
often considered as a "gold standard" for analgesia and 
stress reduction. In this study, we observed the analgesic 
effect of TAP block, and compare the effect on the 
neuroendocrine-endocrine of the body with epidural 
anesthesia.  
Research content: 
1. Preoperative examination, recruiting test subjects; 
2. Eligible subjects were randomly assigned to different 
groups; 
3. Different groups: general anesthesia as control group; 
general anesthesia with epidural block group; general 
anesthesia with TAP block group; 
4. Indicators: heart rate (HR) and mean arterial pressure 
(MAP) in different time points: preoperative, anesthesia 
induction before intubation, tracheal intubation, surgical 
incision, surgery after extubation, 6,24,48 hours after 
the surgery. Neurological-endocrine test (cortisol, blood 
glucose, Cytokines) in different time points: 0,6,24,48 
hours after surgery. Opioid use, pain scores, adverse 
reactions and complications. 
participants recruited 

1. Admission criteria: elective surgery for open gastric 
cancer radical surgery patients, 20-75 years old, ASAI 
~ III level, no local anesthesia history, no vital organ 
dysfunction. 
2. Exclusion criteria: emergency patients, preoperative 
infection, immune and endocrine system diseases, 
radiotherapy and chemotherapy history, preoperative 
blood transfusion patients. 
3. Termination criteria: TAP block failure or with severe 
complications, epidural block failure or with severe 
complications, patients who undergo perioperative 
excessive bleeding need blood transfusion, and 
patients who voluntary withdraw from the study.