Synergistic Effects of Low-Dose Caffeine and Taurine on Anaerobic, Neuromuscular, and Cognitive Performance: A Double-Blind Randomized Placebo-Controlled Crossover Study
Phase: NA
Conditions: Anaerobic Performance Neuromuscular Performance Cognitive Performance
Sponsor: Ankara University

 
 
COVER PAGE 
 
Official Title 
Synergistic Effects of Low-Dose Caffeine and Taurine on Anaerobic, Neuromuscular, and 
Cognitive Performance: A Double-Blind Randomized Placebo-Controlled Crossover Study 
NCT Number 
NCT: Pending (Not yet assigned) 
 
Document Type 
Informed Consent Form 
 
Document Date 
March 6, 2026 
 
Sponsor / Responsible Party 
Burdur Mehmet Akif Ersoy University 
 
Principal Investigator 
Yakup Köse 

 
 
Synergistic Effects of Low-Dose Caffeine and Taurine on Anaerobic, 
Neuromuscular, and Cognitive Performance: A Double-Blind Randomized 
Placebo-Controlled Crossover Study 
 
 
 
 
 
 
 

CONSENT FORM 
 
 
Synergistic Effects of Low-Dose Caffeine and Taurine on Anaerobic, 
Neuromuscular, and Cognitive Performance: A Double-Blind Randomized 
Placebo-Controlled Crossover Study 
Dear Volunteer, 
You are invited to participate in the research study named above. Before deciding whether to take part in this 
research, it is important that you understand the purpose of the study and what participation involves. Please 
read the following information carefully. If you have any questions, please feel free to ask and request clear 
explanations. 
The aim of this research project is to investigate the acute effects of low-dose caffeine (2 mg/kg) and taurine 
(10 mg/kg), administered separately and in combination, on anaerobic performance (handgrip strength test and 
Wingate test), cognitive performance (Go/No-Go task), blood lactate levels, and perceived exer-tion in trained 
men. 
Within the scope of the study, each participant will complete the tests under four different experimental con- 
ditions determined in a randomized order: 
Caffeine + Placebo, Taurine + Placebo, Caffeine + Taurine, and Placebo + Placebo. 
The study is designed as a double-blind and counterbalanced crossover trial. On each test day, supplements 
will be administered to participants in capsule form, and the testing protocol will begin 60 minutes after supp- 
lementation. Experimental sessions will be separated by at least 72 hours. 
During each testing session, participants will undergo the following procedures in sequence: 
• 
Body composition analysis (InBody 770, InBody Co., Seoul, Korea) 
• 
Handgrip strength measurement using a digital hand dynamometer (measured for both hands, with 
dominant hand recorded separately) 
• 
Wingate anaerobic performance test (Monark 894E, Sweden) 
• 
Blood lactate measurement (3 minutes after the Wingate test) 
• 
Rating of perceived exertion using the Borg RPE 6–20 scale immediately after the Wingate test 
• 
Go/No-Go task (reaction time test performed using a computerized system or simple response system) 
Participants will be asked to avoid heavy physical exercise and caffeine consumption for at least 24 hours 
before each testing session. 
No additional procedures other than those applied to other participants will be required from you. In addition 
to you, 31 other adult male participants will take part in this study. 
Participation in this research is entirely voluntary. Participation in this study will not result in any financial 
cost to you or to the Social Security Institution to which you are affiliated. You will also not receive any 
payment for participating in this study. 
The results of this research will be used for scientific purposes only. If you withdraw from the study or are 
withdrawn by the researchers, your data will not be used. However, once the data have been anonymized, it 
may not be possible to remove them from the dataset. Your decision to withdraw from the study will not affect 
any treatment or services you receive. 
All information obtained from you will be kept confidential, and if the study is published, your identity will 
re-main protected. 
If you have any questions or suspect any side effects, you may contact Research Assistant Yakup Köse during 
working hours at (+90 248) 213 14 49, or at any time (24 hours) at +90 533 478 14 77. 
I have read (or had read to me) the two-page information provided above, which contains the information that 
must be given to volunteers before the research begins. I asked the researchers questions about any points that 
I thought were unclear and received satisfactory answers. I believe that I fully understand all the written and 
verbal explanations provided to me. I was given sufficient time to decide whether or not I wish to participate 
in the study. I understand what will happen to me during this research and that I may withdraw from the study 
at any time, with or without giving a reason. I understand that I will receive a copy of this signed consent form. 
Under these conditions, I voluntarily agree that the information obtained about me within the scope of this 
research may be used for scientific purposes and may be presented and published provided that confidentiality 

CONSENT FORM 
 
 
rules are respected, and that I am participating in this study of my own free will without any pressure or coer- 
cion. 
With this information, regarding the samples obtained from me: 
□ I do not allow them to be used in other scientific studies. 
□ I allow them to be used in other scientific studies for scientific purposes, provided that my identity remains 
confidential. 
Volunteer; 
Researcher; 
Name-Surname: 
Name-Surname: Yakup KÖSE 
Date: 
Date: 
Signature: 
Signature: