The Effect of Functional Bread Dadih During Pregnancy and Health Outcomes
Phase: NA
Conditions: Birth Weight, Pregnancy Weight Gain
Sponsor: Andalas University

 
LEADING RESEARCH APPLIED RESEARCH UNIVERSITY OF 
ANDALAS CLUSTER RESEARCH PUBLICATION ACCELERATION OF 
PROFESSORS 
 
 
 
 
 
 
 
 
 
 
 
 
RESEARCH SUB TOPIC: FOOD SECURITY, DRUG, AND HEALTH RESEARCH 
SUB TOPIC: NUTRITION AND HEALTH 
RESEARCH TITLE 
 
EFFECTS OF DADIH FUNCTIONAL BREAD ON THE MICROBIOTA 
PROFILE OF PREGNANT WOMEN AND INFANT BIRTH WEIGHT 
INCREASE 
BY: 
PROPOSING RESEARCHER: 
 
Dr. HELMIZAR, SKM, M. BIOMED 
 NIDN. 0010117309 
Dr. AZRIMAIDALIZA, SKM, MKM 
Dr. FERDINAL FERRY, SpOG (K) 
Dr. FRIMA ELDA, SKM, MKM 
dr. ASRAWATI, M.BIOMED, SpA (K) 
 
 
 
 
Document Date : 02 January 2023 
 

This research was conducted in several stages including the following: 
 
1. Participant Flow 
Based on the results of the research implementation, there were 88 respondents and a baseline was 
carried out and intervention was given (giving bread and curd vla for 3 months). The respondents were divided 
into two groups, namely intervention and control. The intervention group is the group that is given the treatment 
and the control group is the placebo group. 
 
 
a. Recruitment Details 
This research began on May 9 2022 to August 30 2022 (baseline stage 1) and at the baseline 
stage 2 on September 20 2022 it was continued with intervention and ended in November 2022. The 
working area of the health centered is several selected health centered in Padang City according to the 
Locus Stunting in Padang City. 
 
 

b. Title Group 
Group 1 respondents were intervention respondents 
c. 
Group Definition 
The intervention group is the group that was given the treatment (bread and curd custard). 
 
2. Baseline Characteristics 
 
Based on the table below, the total number of respondents who were successfully baselined was 106 
people, but after being reconfirmed and adjusting to the inclusion criteria, 18 respondents dropped out. For 
this reason, the total number of respondents who took part in the research (intervention) was 88 people. The 
sample respondents will be divided into two groups, namely the intervention group and the control group. 
 
Research sites 
Date and time 
Number of 
Samples 
Andalas Health Center 
Wednesday/27 July 2022 
16 
Nanggalo I health center 
Thursday/28 July 2022 
29 
Nanggalo II Public Health Center Tuesday/ September 20, 2022 
19 
Kuranji I Health Center 
Monday/ September 19, 2022 
19 
Kuranji II Health Center 
Tuesday/ September 20, 2022 
23 
Total (Drop Out 18 respondents) 
106 
Total of All Samples 
88 
 
 
a. Group Information 
Respondent criteria in this study are; mothers with a gestational age of 12 – 20 weeks, in good health, 
willing to take part in the study with the stages of filling out questionnaires, collecting blood, and participating 
in the puskesmas to carry out ultrasound examinations, not moving before delivery, not suffering from certain 
diseases such as ( Tuberculosis, Diabetes Mellitus, Hypertension, History of Preeclampsia, or currently 
taking regular medication). As well as signing an informed consent, and willing to consume curd bread and 
vla until delivery. 
b. Title Group 
Group 1 respondents were intervention respondents 
c. 
Group Definition 
The intervention group is the group that was given the treatment (bread and curd custard). 
d. Baseline Analysis of Population Information (Overall Total Baseline) 
 
The overall baseline is 106 people. 
 
e. 
Basic Measurement Information 
 
The basic measurements for pregnant women include mother's ethnicity, mother's education, mother's 
occupation, mother's knowledge, family income, family members who smoke, mother's age, and gestational 
age. Basic measurements for newborns include birth weight, birth length, head circumference, chest 
circumference, and arm circumference. 
 
 
 
 

f. 
Basic Measurement Title 
 
The average maternal weight before and after the intervention, and the average body mass index 
measurement before and after the intervention. 
 
g. Specific Measurements 
 
Specific measurements such as the mother's weight before and after giving the intervention, measuring 
the body mass index before and after the intervention, as well as measuring the acceptability of bread and 
curd products. 
 
h. Respondent Age 
 
Respondents' ages were women of reproductive age ranging from 18 to 45 years. 
 
i. 
Gender 
 
The specified gender is female. 
 
j. 
Race and Ethnicity 
 
Minangkabau specific race and ethnicity 
 
k. Measurement Type 
 
The number of participants was 88 people. 
 
l. 
Dispersion measure 
 
Complete 
 
m. Baseline Measurement Data 
 
The data is in the form of numbers in the results table. 
 
n. Unit of Measurement 
 
The basic unit of measurement for age is years, for education level are elementary school, junior high 
school, senior high school, and college. 
 
3. Outcome Measures 
 
a. Outcome measures Information 
 
Based on the research that has been done, the results obtained are the mother's weight gain, difference, 
and body beat as well as the length of the baby's body that was born. 
 
b. Outcome measures Type 
 
The type of outcome measure is primary data. 
 
c. 
Outcome measures Title 
 
The title of the outcome measures was the acceptability test for bread products and dadih sauce in the 
intervention and control groups, the differences in mean body weight and body mass index in the baseline, 

intervention, and control groups, and the differences in outcome in weight and birth length of infants in the 
intervention and control groups. 
 
 
d. Outcome Measurement Time frame 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
e. 
Title Group 
Group 1 respondents were intervention respondents and group 2 respondents were control respondents. 
f. 
Group Description 
The intervention group is the group that was given the treatment (bread and curd custard). 
g. Baseline Analysis of Population Information (Overall Number of Participant Analyzed) 
 
The overall baseline is 106 people. 
 
h. Outcome Measurement Type 
 
The type of measurement of the results is the average. 
 
Survey of respondents 
(April – June 2022) 
Respondent Baseline 
(June – July 2022) 
Total Actual Respondents  
(July 2022) 
Phase I Intervention 
(27 July 2022) 
Phase II Intervention 
(18 September 2022) 
1st Weighing 
(August 2022) 
2nd Weighing 
(September 2022) 
3rd Weighing 
(October 2022) 
Baby Weighing 
(November 2022) 

 
i. 
Dispersion measure 
 
Complete 
 
j. 
Outcome Measures Data 
 
The outcome measure data is attached to the manuscript to be submitted. 
 
k. Unit of Measure 
 
The unit for measuring mother's weight is Kilograms, for height is Centimeters, for measuring baby's 
weight is Grams, and body length is Centimeters. 
 
l. 
Statistical analysis 
 
Statistical analysis used a randomized controlled trial (RCT) design and previously performed a data 
normality test using Kolmogorov Smirnov and using the T-Independent test. With a p-value <0.05. 
 
4. Adverse Events 
 
a. All-cause mortality 
 
No, There is’nt 
 
b. Serious adverse events 
 
No, There is’nt 
 
c. 
Other adverse events 
 
No, There is’nt 
 
d. Time frame 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Initial screening = 
106 samples 
Does not meet the criteria = 18 
1. Abortion n = 6 (July 2022) 
2. Moved domicile n = 7 (July 2022) 
3. Another reason n = 4 (July 2022) 
4. Gestational age past month = 1 
(July 2022) 

 
e. 
The collation approach for the default table 
 
No, There is’nt 
 
f. 
The total number affected by all causes of death 
 
No, There is’nt 
 
g. Total At-Risk Number of Deaths from All Causes 
 
No, There is’nt 
 
h. Total Number Affected by Each Serious Adverse Event 
 
No, There is’nt 
 
i. 
Total At Risk for Serious Adverse Events 
 
4 people 
 
j. 
Frequency Threshold for Reporting Other Unexpected Events (Excluding Serious) 
 
No, There is’nt 
 
k. Total Number Affected by Other Unexpected Events (Excluding Serious) Above the Frequency 
Threshold. 
 
No, There is’nt 
 
l. 
Total At Risk for Other Unexpected Events (Excluding Serious) 
 
No, There is’nt 
 
m. Term Unexpected Event 
 
Pregnancy, Postpartum, and Perinatal. 
 
n. Collection Approach 
 
No, There is’nt 
 
o. Bad event data 
 
Number of participants affected : None 
Number of at-risk participants : None 
Number of occurrences : None 
 
 
5. Limitations and Caveats 
 
The obstacle in this study was that at the time of recruitment there were also many mothers who did not 
want to participate because they were afraid of taking blood and the reason was that their husbands did not allow 
it. Apart from that, the delivery of curd bread and vla is sometimes hampered by rainy weather. The distance 
between the respondent's house is far enough to be traveled every day. In addition, there are also mothers who 

are getting bored and nauseous consuming bread, because they are experiencing a phase of nausea and vomiting. 
And mothers want more varied types of bread so they don't get bored. The condition of the product is because it 
does not use preservatives so it quickly becomes sour and smells. So that mothers do not want to eat it. Mother's 
health condition is also an obstacle, due to the rainy season, many mothers are sick so they don't have an appetite 
to eat and consume curd vla bread. Besides that, 
 
6. Certain Agreements 
 
Yes. Sponsor's Employee Principal Investigator 
 
 
7. Results Point of Contact 
 
Official Name or Title 
 
: Dr. Helmizar, SKM, M. Biomed 
Organization Name 
  
: University of Andalas 
Telephone 
 
 
: +62 812-6776-930 
E-mail  
 
 
: helmizar@ph.unand.ac.id 
 
 
8. Delayed Results 
 
No, There is’nt