Comparative Clinical Evaluation of Coronally Advanced Flap With Platelet Rich Fibrin Membrane and Chorion Membrane in the Treatment of Human Gingival Recession
Phase: NA
Conditions: Gingival Recession
Sponsor: Institute of Dental Sciences, Bareilly, Uttar Pradesh, India

COVER PAGE 
 
 
 
 
 
 
 
Date- 04-12-2015. ETHICAL APPROVAL. 
 
 
Study Title- 
 
Comparative clinical evaluation of coronally advanced flap with 
platelet-rich fibrin membrane and chorion membrane in the 
treatment of human gingival recession 
 
 
 
 
 
 
 
 
 
 
 
 
 

 
 
 

 
 
 

ABSTRACT 
 
Background:  Platelet-rich fibrin (PRF) is a second-generation platelet concentrate and has the 
potential to accelerate soft and hard tissue regeneration. The chorion membrane is a fetal tissue. 
It has been used for its exceptional wound-modulating properties. The aim of the present study 
was to evaluate and compare the clinical outcome of PRF and chorion membrane in the 
treatment of isolated Miller’s class I or II gingival recession defects. 
Materials and methods: A total of 50 recession defects were treated randomly with coronally 
advanced flap (CAF) along with PRF membrane (site A, n = 25 defects) or CAF with chorion 
membrane (site B, n = 25 defects). Clinical parameters measured at baseline, 1 month, 3 months 
and 6 months were recession depth (RD), recession width (RW), clinical attachment level 
(CAL), width of keratinised gingiva (WKG), plaque index (PI), gingival index (GI) and 
assessment of gingival biotype. Statistical analysis was performed to compare the treatment 
outcomes at the follow-up intervals. 
Results: Six months after the surgery, statistically significant improvements in mean root 
coverage, RD, RW, CAL, WKT, PI and GI were observed in both groups. No statistically 
significant difference was found between the two groups for all of these parameters. The mean 
percentage of root coverage was 86.76 ± 13.76 in the PRF group (site A) and 82.89 ± 15.65 in 
the chorion group (site B) at six months post-operatively, with no statistically significant 
difference between them. The gingival biotype also showed a thick biotype in sites that had an 
initial thin biotype. 
Conclusion: Both PRF and chorion membrane are adequate and predictable treatment 
modalities for the management of isolated recessed-type defects. Longitudinal studies are 
needed to confirm these findings.  
Keywords: Coronally advanced flap, gingival recession defect, platelet-rich fibrin, root 
coverage, chorion membrane. 

Statistical Analysis 
 
 
 
 

 
 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 

ANNEXURE – II 
 
INFORMED CONSENT 
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doctor has provided me with complete details about the proposed procedure/treatment. I have 
been informed about the purpose of the procedure and the possible risks/complications 
involved. 
“I hereby declare that I am fully agreeing, of my own free will, to undergo this 
procedure/treatment for its successful completion.” 
Patient’s Signature: ___________________________