Do Total 30 Sphere Contact Lenses Provide a Comfortable Wearing Experience All Day?
Phase: NA
Conditions: Contact Lens Complication, Dry Eye
Sponsor: University of Alabama at Birmingham

Total30 Sphere Contact Lenses 
 
 
Study Protocol and Statistical Analysis Plan 
 
 
        NCT05183022 
 
 
        November 17th, 2022 
 
 
Andrew Pucker, O.D.,PhD, Principal Investigator University of Alabama at Birmingham 
Birmingham, AL 35294 

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CONSENT FORM TO BE PART OF A RESEARCH STUDY
Title of Research:
Do Total30 Sphere Contact Lenses Provide a Comfortable Wearing 
Experience All Day?
UAB IRB Protocol #:
IRB-300008004 
Principal Investigator:
Andrew D. Pucker, OD, PhD
Sponsor:
ALCON RESEARCH, LTD
General Information
You are being asked to take part in a research study. This research study is 
voluntary, meaning you do not have to take part in it. The procedures, risks, and 
benefits are fully described further in the consent form.
Purpose
The purpose of the study is to determine if Total30 sphere contact lenses provide 
a comfortable wearing experience all day.
Duration & Visits
You will be in this study for about 1 month. This study will have 3 in person visits, 
which will each last about 1 hour. You will also be asked to complete text surveys 
outside of your study visits. 
Overview of Procedures
This study will include eye tests, surveys, eye comfort logs, and the wearing of 
Total30 sphere contact lenses. You will be asked to wear Tota30 sphere contact 
lenses for at least 16 hours per day. You will also be asked to complete several 
surveys via text message designed to gauge your eye comfort.
Risks
The risks of this study do not exceed that of a normal eye exam. The use of all 
contact lenses comes with a risk of eye irritation or eye infection; however, eye 
infections with contact lenses are very rare.
Benefits
You may not benefit directly from this study, but knowledge gained from this 
study could potentially help future persons who have contact lens discomfort. 
Alternatives
The only alternative to this study is to not take part in this study and to continue 
with your regular eye care.
Purpose of the Research Study
We are asking you to take part in a research study. Although there has been several soft contact lens 
innovations over the past few decades such as the advent of daily disposable contact lenses, about 20% of all 
contact lens wearers drop out of contact lenses annually. The top reason for dropping out of contact lenses is 
eye discomfort, which typically gets worse towards the end of the day. This study plans to determine if Total30 
sphere contact lenses can provide a comfortable wearing experience all day and for the one-month life of the 
contact lens. We plan to enroll a total of 58 subjects at the University of Alabama at Birmingham.
Conflict of Interest Disclosure
Dr. Andrew Pucker, the principal investigator for this study, has received consulting fees from the sponsor and 
from companies other than the sponsor, which may affect his financial interests. If you would like more 
information, please ask Dr. Pucker.
Study Participation & Procedures
UAB IRB
Approved
29-Oct-2021

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If you agree to participate, you will be asked to come in for 3 in person visits over the course of 1 month, which 
will each last about 1 hour. You will be asked to complete surveys used to gauge eye comfort, and you will be 
asked complete the below procedures. The testing listed below is often included in a typical eye exam. 
Study Visit 1: Baseline

Subject History, Eligibility, Informed Consent: You will be asked to complete a screening survey to verify 
that you are eligible for the study. This screening survey will include the Contact Lens Dry Eye-8 
Questionnaire (CLDEQ-8), which is a contact lens comfort survey. We will also fully explain this study to 
you and let you decide if you would like to participate. 

Visual Acuity with Glasses: We will evaluate your ability to read the eye chart.

Glasses Prescription: We will determine your glasses prescription with a machine called a phoropter, and 
we will determine how well you can read the eye chart with this prescription.

Slit-Lamp Biomicroscope: We will use a lighted biomicroscope to document your anterior eye health. 

Contact Lens Fitting: We will fit you in Total30 sphere contact lenses, and we will teach you how to use 
these contact lenses. We will also give you everything you need to take care of the contact lenses. 

Compliance & Daily Comfort: We will send you a test text message to make sure they you can complete 
our virtual comfort surveys. We would like you to wear your contact lenses at least 16 hours per day, and 
we would like you to start wearing them between 6:00 AM and 8:00 AM on the days that you will be 
completing the text messaging surveys. You will need to complete the surveys on days 1, 2, 3, 4, 5, 14, and 
1 day before your last study visit. We will call you to remind you about the day 14 end last surveys. On the 
days we ask you to complete surveys, you will need to complete a survey before CL application, directly 
after CL application, and at 8 hours, 10 hours 12 hours, 14 hours, and 16 hours post lens application. Each 
survey should not take more than 5 minutes to complete. 
Study Visit 2: 1 Week 

Questionnaires: We will ask you to complete the CLDEQ-8 questionnaire as well as an investigator 
designed survey to judge your contact lens wearing experience, eye symptoms, and vision. 

Visual Acuity with Contact Lenses: We will evaluate your ability to read the eye chart.  

Slit-Lamp Biomicroscope: We will use a lighted biomicroscope to document your anterior eye health.

Contact Lens Evaluation: We will evaluate the fit of your contact lenses. Contact lens adjustments will only 
be made if they improve your vision on the eye chart. If a contact lens adjustment is made, you will need 
to repeat the first week of contact lens wear with a new set of contact lenses.
Study Visit 3: 1 month 

Questionnaire: We will ask you to complete the CLDEQ-8 questionnaire as well as an investigator designed 
survey to judge your contact lens wearing experience, eye symptoms, and vision. 
Visual Acuity with Contact Lenses: We will evaluate your ability to read the eye chart.  
Slit-Lamp Biomicroscope: We will use a lighted biomicroscope to document your anterior eye health.
Completion: You will be compensated for your time, and you will be released from the study. 
Additional Information:
Your research data will be stored in a de-identified manner (private information with all identifiers removed). 
Your de-identified private information may be used for future research studies or distributed to another 
researcher for future research studies without additional informed consent. This is only when there are no 
identifiers associated with the data.

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Risks and Discomforts
This study does not have any inherent risks greater than a normal contact lens exam or contact lens wear. 
Contact lens wearers may have mild discomfort while wearing their contact lenses. Contact lens wear may lead 
to red eyes, uncomfortable eyes, temporarily decreased or permeant vision loss, or even an eye infection; 
however, these issues are very rare if the contact lenses are worn correctly. Ask the study doctor if you have 
any questions about wearing contact lenses. You will also need to use a contact lens care system to clean your 
contact lenses (ClearCare). This solution contains hydrogen peroxide, which can burn your eye if you do not 
use the solution correctly. ClearCare is only safe if it is naturized for 6 or more hours in the provided contact 
lens case. If used corrected, ClearCare is one of the safest and most effective contact lens care systems in the 
market. If you have any questions about using ClearCare, please ask the study doctor. 
Benefits
You may not benefit directly from taking part in this study. However, knowledge gained from this research will 
help the medical community better understand if Total30 sphere contact lenses are able to provide all day 
comfort for contact lens wearers. You will also get the opportunity to try a new contact lens. 
Alternatives
Your alternative is to not participate in this study. 
Confidentiality and Authorization to Use and Disclose Information for Research Purposes
Federal regulations give you certain rights related to your health information. These include the right to know 
who will be able to get the information and why they may be able to get it. The study doctor must get your 
authorization (permission) to use or give out any health information that might identify you.
What protected health information may be used and/or given to others?
All medical information, including but not limited to information and/or records of any diagnosis or treatment 
of disease or condition, which may include sexually transmitted diseases (e.g., HIV, etc.) or communicable 
diseases, drug/alcohol dependency, etc.; all personal identifiers, including but not limited to your name, social 
security number, medical record number, date of birth, dates of service, etc.; any past, present, and future 
history, examinations, laboratory results, imaging studies and reports and treatments of any kind, including but 
not limited to drug/alcohol treatment, psychiatric/psychological treatment; financial/billing information, 
including but not limited to copies of your medical bills; any other information related to or collected for use in 
the research study, regardless of whether the information was collected for research or non-research (e.g., 
treatment) purposes; records about any study drug you received or about study devices used; and consent 
forms from past studies that might be in your medical record.
Who may use and give out this information?
Information about your health may be used and given to others by the study doctor and staff. They might see 
the research information during and after the study.
Who might get this information?
All individuals/entities listed in the informed consent document(s), including but not limited to, the physicians, 
nurses and staff and others performing services related to the research (whether at UAB or elsewhere). Your 
information may also be given to the sponsor of this research. “Sponsor” includes any persons or companies 

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that are working for or with the sponsor, or are owned by the sponsor, or are providing support to the sponsor 
(e.g., contract research organization).
Information about you and your health which might identify you may be given to:

the Office for Human Research Protections (OHRP)

the U.S. Food and Drug Administration (FDA)

Department of Health and Human Services (DHHS) agencies

Governmental agencies in other countries

Governmental agencies to whom certain diseases (reportable diseases) must be reported

 the University of Alabama at Birmingham - the physicians, nurses and staff working on the research 
study (whether at UAB or elsewhere); other operating units of UAB, UAB Hospital, UAB Highlands 
Hospital, as necessary for their operations; the UAB IRB and its staff of UAB and its billing agents

ALCON RESEARCH, LTD
Why will this information be used and/or given to others?
Information about you and your health that might identify you may be given to others to carry out the 
research study. The sponsor will analyze and evaluate the results of the study. In addition, people from the 
sponsor and its consultants will be visiting the research site. They will follow how the study is done, and they 
will be reviewing your information for this purpose.
What if I decide not to give permission to use and give out my health information?
By signing this consent form, you are giving permission to use and give out the health information listed above 
for the purposes described above. If you refuse to give permission, you will not be able to be in this research.
May I review or copy the information obtained from me or created about me?
You have the right to review and copy your health information. However, if you decide to be in this study and 
sign this permission form, you will not be allowed to look at or copy your information until after the research is 
completed.
May I withdraw or revoke (cancel) my permission?
Yes, but this permission will not stop automatically. The use of your personal health information will continue 
until you cancel your permission.
You may withdraw or take away your permission to use and disclose your health information at any time. You 
do this by sending written notice to the study doctor. If you withdraw your permission, you will not be able to 
continue being in this study.
When you withdraw your permission, no new health information which might identify you will be gathered 
after that date. Information that has already been gathered may still be used and given to others. This would 
be done if it were necessary for the research to be reliable.
Is my health information protected after it has been given to others?
If you give permission to give your identifiable health information to a person or business, the information may 
no longer be protected. There is a risk that your information will be released to others. Including others 
outside of UAB, without your permission.
Voluntary Participation and Withdrawal

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Whether or not you take part in this study is your choice. There will be no penalty if you decide not to be in it. 
If you decide not to be in the study, you will not lose any benefits you are otherwise owed.
You are free to withdraw from this study at any time. Your choice to leave the study will not affect your 
relationship with this institution. However, you should return to see the study doctor for safety reasons so you 
can be taken off the study drug and referred for follow-up care. Contact the study doctor if you want to 
withdraw from the study.
You may be removed from the study without your consent if the sponsor ends the study, if the study doctor 
decides it is not in the best interest of your health, or if you are not following the study rules.
If you are a UAB student or employee, taking part in this research is not a part of your UAB class work or 
duties. You can refuse to enroll or withdraw after enrolling at any time before the study is over, with no effect 
on your class standing, grades, or job at UAB. You will not be offered or receive any special consideration if you 
take part in this research.
Cost of Participation
There will be no cost to you for taking part in this study. 
Payment for Participation
You will be paid $200 via a Greenphire Clincard at the completion of this 1-month study to compensate you for 
the time that you devoted to this study. A $100 dollar bonus is available to those who complete at least 90% of 
the text message surveys. If you do not meet the study’s requirements based upon your baseline study visit 
numbers, you will be compensated $20 for your time. The contact lenses and care products (contact lens case 
and contact lens solution) used in this study will be provided at no charge. Ask the study staff about the 
method of payment that will be used for this study (e.g., check, cash, gift card, direct deposit).
Payment for Research-Related Injuries
UAB and Alcon have not provided for any payment if you are harmed as a result of taking part in this study. If 
such harm occurs, treatment will be provided. However, this treatment will not be provided free of charge.
New Findings
You will be told by the study doctor or the study staff if new information becomes available that might affect 
your choice to stay in the study.
Questions
If you have any questions, concerns, or complaints about the research or a research-related injury including 
available treatments, please contact the study doctor. You may contact Dr. Andrew D. Pucker at (205) 975-
9938 or after hours by emailing him at apucker@uab.edu.
If you have questions about your rights as a research participant, or concerns or complaints about the 
research, you may contact the UAB Office of the IRB (OIRB) at (205) 934-3789 or toll free at 1-855-860-3789. 
Regular hours for the OIRB are 8:00 a.m. to 5:00 p.m. CT, Monday through Friday.

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Legal Rights
You are not waiving any of your legal rights by signing this consent form.
Signatures
Your signature below indicates that you have read (or been read) the information provided above and agree to 
participate in this study. You will receive a copy of this signed consent form.
Signature of Participant
Date
Signature of Person Obtaining Consent
Date

Version 6 
 
Do Total30 Sphere Contact Lenses Provide a Comfortable 
Wearing Experience All Day? 
 
 
Principal Investigator: 
Andrew D. Pucker, OD, PhD, FAAO, FSLS, FBCLA 
 
 
Additional Support: 
Amy Logan, OD 
Terri Call, OD 
Quentin Franklin, BS 
 
University of Alabama at Birmingham 
School of Optometry 
1716 University Blvd 
Birmingham, AL 35233 
apucker@uab.edu 
(920) 579-2900 
 
 
 
 
 
 

Version 6 
I. INTRODUCTION & RATIONALE 
 
Contact lens (CL) discomfort affects most CL wearers with discomfort consistently topping the reasons why 
established CL wearers drop out of CLs.1 In fact, studies have consistently found that the frequency of CL 
dropout is around 20% with this dropout frequency staying relatively stable over the past 20 plus years.1 This 
static frequency of CL dropout is surprising since there have been a number of dramatic soft CL innovations 
during this time frame (e.g., widely available daily disposable CLs, silicone hydrogel CL materials with high 
oxygen transmissibility, new CL surface coatings).2  
 
Another common issues that CL wearers frequently face is that their discomfort symptoms increase towards 
the end of the wear day.3 This burdensome discomfort can unfortunately cause patients to remove their CLs 
before their desired wear time.4 While comfortable wear times vary from patient to patient, Terry et al. has 
suggested that patients should be able to comfortably wear their CLs for at least 12 hours per day for at least 6 
days per week.5 Nevertheless, the literature currently lacks sufficient data to comment fully on the full day wear 
experience, which for many patients may be 16 or more hours per day, especially if they have demanding 
careers. One CL that has the potential to allow for all day comfort is the Total30 Sphere CLs, which is a new 
water gradient, monthly CL aimed at delivering all day comfort and visual performance. Therefore, the purpose 
of this study is to map comfort over the full wear day in established, asymptomatic, soft CL wearers who are 
refit in Total30 Sphere CLs. These data are not only important for judging the performance of Total30 Sphere 
CLs, but they will provide some of the first insights into the full day CL wearing experience over one month.  
 
II. SPECIFIC AIM 
 
We plan to accomplish our goals by pursuing the following specific aim and testing the associated hypothesis: 
 
Aim 1: Determine if Total30 Sphere CLs provide a comfortable wearing experience all day. 
Hypothesis 1: Patients who are refit in Total30 Sphere CLs will have a comfortable wearing experience 
after 16 hours as based on visual analog scale (VAS) scores.  
 
III. STUDY DESIGN  
 
Subjects 
 
This one-month, three-visit study will be conducted at the University of Alabama at Birmingham (Birmingham, 
AL, USA). Subjects will be recruited via clinic records, email, and fliers. Subjects will be screened prior to the 
study visit with an IRB approved phone screening survey. Adult, 18- to 45-year-old, CL wearers who have 
20/20 visual acuity or better and who are minimally symptomatic will be recruited (Contact Lens Dry Eye 
Questionnaire [CLDEQ]-8 ≤10).3, 6 Subjects will be required to be able to wear Total30 Sphere CLs, and they 
will be required to have a smart phone with text messaging capabilities to be able to answer electronic survey 
questions. Subjects will be required to have astigmatism better than or equal to -0.50 D in each eye, and they 
will be required to have regularly worn 2 week or monthly CLs within the past 6 months and be a current CL 
wearer. Subjects will be required to provide a glasses prescription that is less than 3 years old. Subjects will be 
required to be willing to start wearing their CLs between 6:00 AM and 8:00 AM and wear their CLs until 11:00 
PM each day text messaging data is collected. Subjects will be excluded if they are current or past hard CL 
wearers, have known systemic health conditions that are thought to alter tear film physiology, have a history of 
viral eye disease, have a history of ocular surgery, have a history of severe ocular trauma, have active ocular 
infection or inflammation, are currently using isotretinoin-derivatives or ocular medications, are currently using 
rewetting drops or artificial tears, or if they are pregnant or breast feeding.7  
 
Sample Size  
 
This will be a pilot study to understand CL comfort throughout the day in monthly soft CL wearers. We estimate 
that 48 subjects will be enough to gain a general understanding of ocular comfort across the entire day based 
upon past research (40 subjects + 8 subjects to account for attrition and missing data).8-10 An additional 10 
subjects are being requested to account for screen fails; however, recruitment will stop when 48 subjects fully 
qualify for this study (max of 58 subjects).  

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Surveys and Clinical Tests 
 
Visit 1: Baseline  
 
1. Subject History, Eligibility, Informed Consent: Subjects will be asked to repeat the IRB approved phone 
screening survey at the study visit to verify that they are still eligible for the study. All subjects will be screened 
with the CLDEQ-8 questionnaire regarding their habitual CLs over the past two weeks to verify that they are 
asymptomatic CL wearers. While subjects will be asked to report to the visit without their CLs, they will be asked 
to complete the CLDEQ-8 as if they are wearing their habitual CLs. All relevant patient demographics will be 
collected via a questionnaire developed by the investigators. Non-eligible subjects will be dismissed at this time 
or rescheduled depending upon the reason for ineligibility. Eligible subjects will be enrolled, consented, and 
requested to sign a privacy document.  
 
2. Visual Acuity with Spectacles: Visual acuity will be measured with a Bailey-Lovie high-contrast chart.  
 
3. Manifest Refraction: The investigator will determine the subject’s refractive error with a phoropter, and 
binocular balance will be performed if best-corrected visual acuity is equal in between eyes.  
 
4. Slit-Lamp Biomicroscopy: The investigator will use a slit-lamp biomicroscope to document normal and/or 
remarkable findings of the anterior eye structures: eyelashes (blepharitis), eyelids, conjunctiva, and cornea.  
 
5. CL Fitting: Subject will be fit in Total30 Sphere CLs. The CLs will be evaluated for centration, movement, 
coverage, and CL power adjustments will only be made if they improve Snellen visual acuity. Subjects will be 
given a 1-month supply of CLEAR CARE® CL solution. Subjects will be educated on how to use CLEAR CARE®. 
 
6. Subject Compliance & Daily Comfort: All subjects will be encouraged to wear their CLs for at least 16 hours 
per day and to start wearing their CLs between 6:00 AM and 8:00 AM on days that they will be completing text 
messaging surveys. Subjects will be educated that they will be required to complete Qualtrics surveys on their 
phone. Subjects will be asked to complete a test survey before they leave the first study visit to make sure that 
they system is compatible with their phone. These surveys will ask subjects about their eye comfort with a visual 
analog scale (slider scale with 0 as neutral comfort, -50 extremely uncomfortable, and +50 extremely 
comfortable) at before CL application, directly after CL application, and at 8 hours, 10 hours 12 hours, 14 hours, 
and 16 hours post lens application on the first 5 days. This same system will be used to monitor how many hours 
they wear their CLs each day. Subjects will finally be asked to complete these surveys on day 14 and 1 day prior 
to their 1-month visit (1 month) to understand comfort over the life of the CLs. Subjects will be called the day 
before the day 14 and 1-month surveys to remind them about these surveys. Subjects will be allowed to schedule 
their day 14 and 1-month surveys within 3 days of these time points to allow for better compliance.   
 
Visit 2: 1 Week 
 
1. Visual Acuity with CLs: Visual acuity will be measured with a Bailey-Lovie high-contrast chart.  
 
2. Slit-Lamp Biomicroscopy: The investigator will use a slit-lamp biomicroscope to document normal and/or 
remarkable findings of the anterior eye structures: eyelashes (blepharitis), eyelids, conjunctiva, and cornea.  
 
3. CL Evaluation: The CLs will be evaluated for centration, movement, and coverage, and lens power 
adjustments will only be made if they improve Snellen visual acuity. If a refractive error adjustment of more than 
0.25 D is made, the patient will be given a new set of lenses and be required to repeat the 1-week visit.  
 
Visit 3: 1 Month  
 
1. Visual Acuity with CLs: Visual acuity will be measured with a Bailey-Lovie high-contrast chart.  
 
2. Slit-Lamp Biomicroscopy: The investigator will use a slit-lamp biomicroscope to document normal and/or 
remarkable findings of the anterior eye structures: eyelashes (blepharitis), eyelids, conjunctiva, and cornea.  

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3. CL Evaluation: The CLs will be evaluated for centration, movement, and coverage, and lens power 
adjustments will only be made if they improve Snellen visual acuity. If interested, the patient will be given a 
prescription for the CLs upon request.  
 
4. Study Completion: The subject will be compensated for their time, and they will be released from the study.  
 
Data Analysis 
 
All data will be analyzed with Stata/IC 15 (StataCorp LLC; TX, USA). VAS comfort scores will serve as the 
primary endpoint and be reported as percent of patients who are comfortable at each timepoint. Comfort 
comparisons across visits or across the wear day will serve as exploratory endpoints, and these outcomes will 
be measured with paired t-tests or ANOVA.  
 
Training of Study Personnel 
 
Prior to enrolling any subjects all examiners will participate in a training session developed by Andrew D. Pucker, 
OD, PhD. This full investigator meeting will ensure that all study investigators are performing the procedures in 
the same manner. Data from each investigator’s first subject will also be monitored for quality control by the 
study’s coordinator before the investigator is allowed to see additional subjects.  
 
IV. Study Timeline 
 
  
2021 
2021 2021 2021 2021 
2021 
  
July 
Aug 
Sep 
Oct 
Nov 
Dec 
Activity 
 
Contracting 
  
 
 
 
 
 
IRB Preparation  
  
 
  
  
  
  
Data Collection  
  
 
  
  
  
  
Data Analysis 
 
 
 
 
 
 
Final Study Report 
 
 
 
 
V. Publication Plans 
 
An abstract describing comfort across the wear day will be submitted to Academy 2022 San Diego (main 
outcome), and an abstract will be submitted to Heart of America Eye Congress describing how comfort 
changes over the wear month. A manuscript on the same topics will be submitted to Contact Lens & Anterior 
Eye after the Academy 2022 San Diego abstract is submitted because the Academy requires that abstract 
materials have not been presented/submitted elsewhere.   
 
VI. Conclusions 
 
This project will be among the first to describe the progression of CL comfort throughout the day for Total30 
Sphere CLs. These data are important because they could provide insight into end of day CL discomfort, and 
they will provide data needed for proper patient education. 
   
VII. References 
1. 
Pucker AD, Tichenor AA. A Review of Contact Lens Dropout. Clin Optom (Auckl) 2020;12:85-94. 
2. 
Ngo W, Situ P, Keir N, Korb D, Blackie C, Simpson T. Psychometric properties and validation of the 
Standard Patient Evaluation of Eye Dryness questionnaire. Cornea 2013;32:1204-1210. 
3. 
Pucker AD, Jones-Jordan LA, Marx S, et al. Clinical factors associated with contact lens dropout. Cont 
Lens Anterior Eye 2019;42:318-324. 
4. 
Nichols JJ, Willcox MD, Bron AJ, et al. The TFOS International Workshop on Contact Lens Discomfort: 
executive summary. Invest Ophthalmol Vis Sci 2013;54:TFOS7-TFOS13. 

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5. 
Terry RL, Schnider CM, Holden BA, et al. CCLRU standards for success of daily and extended wear 
contact lenses. Optom Vis Sci 1993;70:234-243. 
6. 
Chalmers RL, Keay L, Hickson-Curran SB, Gleason WJ. Cutoff score and responsiveness of the 8-item 
Contact Lens Dry Eye Questionnaire (CLDEQ-8) in a Large daily disposable contact lens registry. Cont 
Lens Anterior Eye 2016;39:342-352. 
7. 
Sullivan BD, Crews LA, Sonmez B, et al. Clinical utility of objective tests for dry eye disease: variability 
over time and implications for clinical trials and disease management. Cornea 2012;31:1000-1008. 
8. 
Duong K, Pucker AD, McGwin G, Franklin QX, Cox J. An Established Soft Contact Lens Wearers’ 
Awareness of and Initial Experience with Orthokeratology. Ophthalmic Physiol Opt 2021;41:673-682. 
9. 
Maldonado-Codina C, Navascues Cornago M, Read ML, et al. The association of comfort and vision in 
soft toric contact lens wear. Cont Lens Anterior Eye 2021;44:101387. 
10. Diec J, Tilia D, Thomas V. Comparison of Silicone Hydrogel and Hydrogel Daily Disposable Contact 
Lenses. Eye Contact Lens 2018;44 Suppl 1:S167-S172.