Effect of Aerobic Interval Training Versus Resistance Interval Training on Ejection Fraction in Post Stable Myocardial Infarction Patients
Phase: NA
Conditions: Myocardial Infarction
Sponsor: Riphah International University

Aerobic Interval Training v/s Resistance Interval Training On 
Ejection Fraction In Stable Post MI Patients 
   NCT03708484
 
 
 
  
 
 
Cover Page 
Official Title of the study: Effect of Aerobic Interval Training Versus Resistance 
Interval Training on Ejection Fraction in Post Stable Myocardial Infarction Patients 
 
ClinicalTrials.gov Identifier: NCT03708484 
 
Date of the document: November 20, 2016 
 
 

Aerobic Interval Training v/s Resistance Interval Training On 
Ejection Fraction In Stable Post MI Patients 
   NCT03708484
 
DESIGN: Randomized Control Trail 
DATA COLLECTION PROCEDURE: 
After screening of more than 50 MI patients 26 stable post MI patients both males and 
females on the basis of inclusion and exclusion criteria were enrolled. After enrollment final 
step for inclusion in study was 6 minute walk test. All patients performed treadmill 6 minute 
walk test. Patients that successfully completed initial 3 min of walk test were included in the 
study. Informed consent was signed by all patients as an agreement to participate in research. 
Total patients at end of study was 26 with drop outs of 4 .After enrollment in study 1st day 
was pre assessment day.1st step was selection in either control or experimental group. Lottery 
method was used for random allocation of patients. Self structured questionnaire was filled 
that included demographics, patient past medical, surgical, drug history, comorbidites, risk 
stratification. Basic baseline evaluation was done that included ECG, urea, creatinine, lipid 
profile. Pre echocardiography of all patients was done Pre MAC New QLMI was filled by 
examiner herself. After completion of all pre assessment exercise session of the patient was 
started from next session. Total weeks of treatment session were 6. Exercise was performed 3 
times a week on alternating days. Total days of exercise were 18. Before treatment session 
proper warm up for 15 minutes was done Pre vitals including heart rate, BP, Respiratory rate, 
SpO2 was recorded. Karvonens formula was used to calculate 60-80% of target heart rate in 
all patients .The goal of exercise was to reach target heart rate. Emergency trolley consisting 
of major life saving drugs was available that included (Angisid, Injection Atropine, 
Adrenaline, Heparin, Lignocaine, Streptokinase, Nitroglycin, Normal Saline, Glucose) plus 
examiner was qualified in ACLS. Patient speed was increased gradually from first to six 
weeks depending on each patient target heart rate. Likewise weight in quadriceps resistive 
exercise and hand grippers were increased gradually with number of repetitions remaining 
same. Rating of perceived exertion and fatigue scale was used to mark patient dyspnea and 
fatigue level. Patients in control group were given standard aerobic interval treatment while 
patient in experimental group was given aerobic plus resistance interval treatment. During 
session continuous vital monitoring was done using saturation probe and cardiac monitor. 
After completion of session post vitals HR, BP, RR, Spo2 RPE and fatigue Cool down 
exercises were performed to stabilize patient. After completion of total 6 weeks of 
intervention patients post tests were done that included Echocardiography, lipid profile post 
and Mac New QLMI. 
 

Aerobic Interval Training v/s Resistance Interval Training On 
Ejection Fraction In Stable Post MI Patients 
   NCT03708484
 
 
 
 
 
                                           
                                                                                                                                   
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
                                                            
 
 
 
Figure 2: Flow chart showing Data collection procedure  
              N= 30 Stable MI patients  
            Randomization 
        Baseline Evaluation               
Demographics, Hemodynamic, 
6MWT, ECG, Lipid profile
Aerobic Interval Training  
6 weeks  
Aerobic +Resistance Interval 
Training 
6 weeks
Control Group 
n=15 
Interventional Group    
n=15 
PRIMARY OUTCOME  
Ejection Fraction 
SECONDARY OUTCOMES 
MACNEW QLMI 
Lipid profile  
Reassessment of      Outcomes           after 6 
weeks 
           Screening of 50 MI patients  
On Basis of 
Inclusion and 
Exclusion 
Criteria
Loss to Follow 
up Drop Outs 
n=2 
Control n=13 
Loss to Follow 
up Drop Outs 
n=2 
Interventional 
n=13 

Aerobic Interval Training v/s Resistance Interval Training On 
Ejection Fraction In Stable Post MI Patients 
   NCT03708484
 
TREATMENT PROTOCOL: 
Patients in both group received standard treatment that is Aerobic Interval training whereas 
patients in interventional group was given Resistance Interval Training as well. 
Before initiation of treatment protocol vitals (HR, BP, RR and SPO2) will be recorded. 
Treatment of both groups will start with 3-5 minutes of warm up that includes breathing 
exercises and stretching of major large muscles. Exercise will be   performed at 60-80 % of 
intensity calculated by karvonen formula. Throughout training monitoring will be done.  
 
CONTROL GROUP: 
 Patients in control group will perform 6 minutes of cycling followed by 3 minutes of pause 
and again 6 minutes of cycling followed by 3 minutes of pause and finally 6 minutes of 
treadmill followed by 3 minutes of rest. 
 
INTEREVNTIONAL GROUP: 
Patients in Interventional group in first set will perform 3 minute of cycling ,1 set of  hand   
grippers  1.5 to 2.5 lbs (10 to 12 reps) and 1 set of biceps resistive exercises 1 Kg to 3 kg  (10 
to 12 reps) followed by 3minute of pause. In second set patient will perform 3 minutes of  
stationary cycling , 1 set of quadriceps resistive exercises 1 to 3 Kg (10 to 12 reps) again 
followed by 3 minutes of  pause  and in third set patient will perform  3 minutes of  treadmill 
walk at  1.5 to 4 speed, and 1 set of standing ankle pumps (10 to 12 reps). 
 
Patients in both groups will perform cool down exercises that include again breathing 
exercises, stretching and active exercises. Post exercise vitals will be recorded in both groups. 
 
Figure 3: Patient performing  treadmill as a part of treatment protocol  

Aerobic Interval Training v/s Resistance Interval Training On 
Ejection Fraction In Stable Post MI Patients 
   NCT03708484
 
DATA ANALYSIS PROCEDURE: 
All the patients were assessed at the baseline before the intervention and at the completion of 
the study. Data was analyzed by using IBM SPSS 21 (Statistical Package for Social Sciences) 
and expressed in the form of tables and graphs. 
CURVES OF NORMALITY 
          A 
 
 
 
       B  
 
 
       C 
 
 
               D 
  
 
 
        E 
 
Figure 4: Normality test (histograms) for Baseline Vitals, A: Heart rate, B: Respiratory rate, 
C: Saturation, D: Systolic BP, E: Diastolic BP 
 
We applied normality test on Baseline vitals. Histogram showed abnormally skewed curves 
for Heart rate, respiratory rate and oxygen saturation (p=0.000, 0.030, 0.004) respectively and 
normally skewed curves for systolic and diastolic BP (p=0.396 and 0.108) respectively. Test 
of choice is non-parametric, Mann-Whitney U test for the comparison between groups 
(sample size < 30 in each group. 

Aerobic Interval Training v/s Resistance Interval Training On 
Ejection Fraction In Stable Post MI Patients 
   NCT03708484
 
 
 
          A 
 
Figure 5: Normality test (histograms), A: Ejection Fraction  
 
We applied normality test on baseline ejection fraction. Histogram showed abnormally 
skewed curve for ejection fraction (p=0.001). Test of choice is non-parametric, Mann-
Whitney U test for the comparison between groups (sample size < 30 in each group.) 
   
 
 
          A 
 
 
 
 
  B 
 
Figure 6: Normality test (histograms), A: Cholesterol, B: Triglycerides  
 
We applied normality test on baseline cholesterol and triglycerides. Histogram showed 
abnormally skewed curves for cholesterol and triglycerides (p=0.000, 0.026 respectively). 
Test of choice is non-parametric, Mann-Whitney U test for the comparison between groups 
(sample size < 30 in each group 
       

Aerobic Interval Training v/s Resistance Interval Training On 
Ejection Fraction In Stable Post MI Patients 
   NCT03708484
 
 
 
         A 
 
 
                      B      
         
    
 
 
                   C 
 
 
Figure 7: Normality test (histograms) for Baseline Quality of life, A: Emotional state, B: 
Physical state, C: Social state  
 
We applied normality test on baseline quality of life including its three domains of emotional, 
physical and social state. Histogram showed abnormally skewed curve for emotional 
(p=0.025) and normally skewed curves for physical and social state (p=0.129 and 0.577 
respectively). Test of choice is non-parametric, Mann-Whitney U test for the comparison 
between groups (sample size < 30 in each group.)