Evaluation of Acne-induced Hyperpigmentation During Treatment of Acne Vulgaris Subjects With Trifarotene 50 μg/g Cream Versus Vehicle Cream Over 24 Weeks
Phase: PHASE4
Conditions: Acne Vulgaris
Sponsor: Galderma R&D

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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
7.0
PPD
PPD

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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
PPD
PPD
PPD
PPD
PPD
PPD
PPD
PPD
CCI

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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
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++
!&.&<*;$!&$'-5'88* 
+
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++
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+
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+/

#! -&;D
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
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+
$ 5	 %&$!&3* 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
 
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
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/+
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/++
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/+/
-< *<&*!68#$& *
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&=8#--< * ';
$#!& /
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
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/+D

$!&*)8!)'-5 ';*$&-A! &#$	 $ !#-' * 
/

8! &; !#-' *
/+
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 !#-' *6! '*8#- ;#!&$#
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-#$!&9
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D
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D//
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D
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D+
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D/
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D/+
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D/
#!&-$ 5&-8!&*D
D//
**&;$$D/
D/
&*<5&$5** D
D/
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'("#.
8! -'#!%* D
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$65&$5** D
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
7 
0
	
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0/
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0
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0
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+/

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F8$ #@@&$**6#$!&,/
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
 
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/'F:
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/':
 &*/&!
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/':
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
/'8:
"''*/'&+    $%&
/':
&" &%	!#&"!#'
/':
*!%+ &$*# )"&!''*"6%&"&	"&% 
/':
-%, &&*9,*''6%"'# %# )"&!% &@&% 8
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI
CCI

	
	
		
8 
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&#$	 $	,'#&%"%2%!#"!+)*)$%&&%!#*%&*&$%&"%,#'*  #/3"& 
1&&**&%4."*$,* # ,"'"*$,*15 
)! 	5,'#&%%"%2%!#"! &2-%'$$&*+ C+)*)$%&&% 9:
&#$	 $)$*
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#/3"& 1&$!*& "'"%,#'* 
&#$	 $("#<*
)#*) &  &#!+ & ,'#&&""+%! &+ **&%4.
"*$"$)*!&& ,"'"*$%&&*&$%&$!*&"%,#'* 1&
"%2%!#"!) &2%'$$&*++)*)$%&&%>-C?% #/3"& 1&
;&@)&*"55%+) -2-
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15 
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))*H$&'+ %"*#)?*&%*''$%& #'!%"'#!%))*H$&
! &*/#&%FI ;&@)&*"55%+) -2--->'& 5%?%!7I -2->!*5
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

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& &>?&D '%, &> &?(
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
 
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1&&**&%4."*$,* # ,"'"*$,*15 
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#%&'/"$%) &2$%)# '#%'  )*$%%&'+ &*'?$# &*&*
&"$$&&&*#/ &%%"&*##&& &#!+(1%&  %'%1&
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$'"'!/*% )&%&'*!"/ &%%">"'%!*(,#'&%(
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$&! "%&*")&%
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0&:O!#/'/***$&! P** & $#'&%# # )+ "'
/***/+")*&%*  %'/***$&!>"%!$?
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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
 
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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
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*'+&*$%&% , & 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
 
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1&&**&%4."*$,* # ,"'"*$,*15 
$65
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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI
CCI

	
	
		
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 &#8$*$*#$
%)!-
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI
CCI
CCI

	
	
		
 
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1&&**&%4."*$,* # ,"'"*$,*15 
66#$5&$5**
 %$ 5

/ '#&"%*$D '% %-C9,*''  ,*&+ "* &"
1''/%'+@!&<5 # %%0691&&*&$%&(%'+  "%&*
%!D '%  "* H!"& L&)2,'# *&&*&$%&"$)* %(
 &$&   & &*&$%& !*%" %! & 8I "%!%" %&*,'  &
!*%"1''/%*&!*$&069$!'
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
7 
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1&&**&%4."*$,* # ,"'"*$,*15 
#!&-$ 5
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*"%&"% *$D '% %-C9,*''  ,*&+  "*  1''/
%'+@! & <5  # % % 069 1& &*&$%&( %'+   "%&* %!
D '%  "*   H! "& L & )2,'#  * & &*&$%& "$)* %(
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
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 "* 1''/%'+@!&<5 (%!# %%0691&&*&$%&(
%'+  "%&*%!D '%  "* H!"& L&)2,'# *&&*&$%&
"$)* %( &$& &&*&$%&!*%"%!&8I"%!%"%&*,'
&!*%"1''/%*&!*$&069$!'
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
 
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1&&**&%4."*$,* # ,"'"*$,*15 
$65
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"1''/ #$$*@!# %*B#%"+&/' *1* &) &2D '%  "*(
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!	,* %F*'&*?
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
8 

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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI
CCI

	
	
		
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<$%"'!2/*%)&%&'
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI
CCI
CCI
CCI
CCI
CC
I
CCI

	
	
		
 
/
?

	
/+
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)*,'%&%+#&1&*#%!I&%* "&!& $)%&%&$  1%%%
)!$'"' &#!+>'H (7 %! 6%,% ?%!/+C'!*%! *#)>C'!*
8F?&&&!%  "%1 &$ &"$$%!%  %/&'&%!1&)&%& 
"*  '';&@)&*"5 5%)&&+) >2-?>C'!* 8F( T'$%8( +'* ( "
8( %!6''%!* ?  &2%'$$&*+!+ )$%&&%%!*5* 5%)&&+) >-2
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$+/ ! "*&*+&$&# $"#' () &2%'$$&*+*+&$ >-?( %+* ',%
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-! "*/ * !#'*+&$(1'-C! "*/  #/ B#%&)$%&"%-C"%
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) +"'"'$)"&-C"%/!, &&%(%!$%+)&%& * *&&H&*$$ #* &
&*+&*!"&&>*$ ?
 "% "*%"%!*') %!  %*$'@%''"#'*! B#$&% &%&5+&
",%!$%&%"%&*' "%!+&  &/' !&&*&%!  #" &**&%
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%#"'**")&* >		2?**&% "&,%! &/'%5*&%"+& /#&*)!'+
$&/'@!/+#$%)&"$"* $ "$)*!&&*&)"'*&%! ('!%&
$)*,! &+
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)&''"'' * #'&%%!"* !$"*"$!%*$&%)"'!)$%&%%!%&2
)$%&%"&,&+&**&%1  1%%%,, &#! ' &%15 %&TC
$# %'5&**&%! ( %!)&%&''+!#&15*)%&*&%%+)*5*&&"&'
 5%(!)'%I 1!% %"%&!)$%&%"&,&+&*15 &)"'
))'"&%%&TC$# &'-%"%&* &(&**&% 1! %"%&!)$%&%
"&,&+&I%&)$%&&% "*&!+F&*	%!#"&%(%& $$# 
$!'(&%&2)$%&%"&,&+&**&%1 %'+ && &"''+ %"%&
>#/*& ?
 &2%'$$&*++)*)$%&&%""#* && &"%%'$$&*+' % %!& 
 ,*&+"**'& 1&& ,*&+&%'$$&*+)*"  -& (&' &)*&''+(
*,* /'(1,*(&$+&5 ,*'$%& /*&* ',  )%&%# '+("# %
"% !*/'! #*$%&%!! &*  >*$ ? &2%'$$&*++)*)$%&&% 
*B#%&'+*  &%&& %'$!'&+&*&$%& %!%'+&)"'*&%! ,/%)*,%
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
 
 '&'+""# %1''2! %!"%&*''! &#! 1&'%&*$&*&$%& &
15 >D#'%2	% /+88F?-%"%(& ) &%'$$&*+)*"  $&/)*,%&!/+
*!#"%%'$$&%# %&$'+%!3#!"# &*&$%& 1&"%"$&%& #%)*&"&%
>T#//8?$%$%&) &2%'$$&*++)*)$%&&% #'!&**/%
1&&&*&$%&&#%!*'+%%'$$&*+!*$&  
)"'*&%! *# !*&$%$%&"% >+'*8? %!*&**%&* &
%&&*&$%&) &"%) &2%'$$&*++)*)$%&&%;*H$)'(&)"'
&*&%%(* &2'%&*&$%&*$'!2&2$!*&"% /% 1%&*!#"&
))*%"-C(/#&& ' /% 1%&'&%%*$' 5%!'&*&$%&*
"%2%!#"!+)*)$%&&%%)&%& 1&"%1#'!/ %'%&&& "&,
% &/&"%2%!#"!+)*)$%&&%%!"%' % '&#$ &&*&$%& *
"&,% &%'+%& "%!&% (&)"'*&%! *%$)*&%&H")&%
/"# &+*""+% &/&!!&%''+(&)"'*&%! */%"'* 5%
"'* &+&*&%&%'+&"&,"%' % (/#&' ') $'*&-C>, ?
*$"% $"&%%"'#! %/&%&''2'5*")&*>	?2(*!#"&%&
*$&%+)*2)*'*&,5*&% (%!%/&%&2)&1+(&*/+*!#"%
%'$$&%>+'* 8?%!!&%')*)*&+&)"'*&%! &&$5 & %& 
))'%*# % 5%"'*)&%&  &*/'&+&$)*,-C/+%/&%
$'% $&*% *%!"'&&%$'%%! )* %%!*$,'>,  %!R%
?-%& **!(%)%'/'&*'(1&#&)'"/"%&*'( # &!!)'%
$%&*)+%)&%& 1&$'!&$!*&"%,#'* "#'!/&)*,%&%!*!#"
"%2  "&!+)*)$%&&%%)* % "'*>X"+5 ?C1,*('!*%*&%
*&%! *' 5%1%&%!#"**&&%1"$+%&#*%%*&) &%'$$&*+
)$%&&%>, ?5%+)*)$%&&%:.>I?*"&,%!.*
,"'))'"&% &! "'*&%:.>I?*"&,%!.*,"'
**&%(%1%*&%&)"'*&%!1&& #%B#'+ '"&, $"% $"&%%
		2Y(%!#" '  **&&%%!$+&**/%!'&)"'%&*/&&
$%$%&"%%!&&*&$%&"%2%!#"!+)*)$%&&%  "&!1&&
$3*"%"*%1&&# &)"'*&%! % 5%"'*%"'#! &)&%&'*
%!#"%*&%!!*$&& (1" "*"&*@!/+H*  ()'%(%!*+&$&
 5%>+'*8?** ,*'1+ &$&&& !,* "&%!)*,%&#*&*
1* %%"%2%!#"!)$%&&% %"'#!%&&%)&%& %'1*
"%"%&*&% &)"'*&%! (*" %"*$*'&%>,*'?**&%( /%
 '"&,		2Y % &1&'1"%"%&*&%%!%"*$*$#'&%1#'!/))*)*&
*# %-C"%' ( &!!&%&)"'%&'$ &#*@*>, ( R%( %!
+'*8?%!,!% #%H) #* *"$$%!! )*&& 5%"**$%%"%
)&%& 
%$@% 5%**&&%%!)&)*&"&%"%/",!/+&# %%2
"$!%"$ &#*@* 1&))*)*&;&&+!*&%!)*&"&& 5%*$
**!&%>"**( '	  F(%! S"%*(? H) #*&*!&% 
5%1%&"%&*/#&&)$%&! *!* %"'#!%-C( '*)*&"&% 5+'$%&%& 
$%$%&>T$ 7?
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
F 
% #**'/'&+ &""+    $%& ()&%& 1''/% &*#"&!&,! #%H) #*
!#*%&"#* & &#!+%!&# &' &&1"2!'+/*!2 )"&*#$ #% "*%>;
FA?
 &#*@%"*$1''' /)*,!!*!'+# &'$&**&&% ' (# %%
))*)*&"'% *1''*!#"'%&"%!1''%&"& 5%+!*&%*& 5%
/***#%"&%
"%"%)*  &*+* %!$+ *# '+ "& ) +" "'!,')$%&(* #'&%%
$&%')*/'$ (1&!*1'*$  "&+(%!!)*  %>T88? -%&&*&!("%
$+"#  *# )+ "'%!$&%' "**%%!"% %"%&'+$)"&&B#'&+'
& "&!/+&!  > &%88?**(&  &#!+$ &,'#&""+
**&%%"%' % %!"%2%!#"!+)*)$%&&%%'' 5%)&&+) #/3"& 
'"'&'*%"&&*&$%&*$%%&*$ *+&$( "'%(!*+%  (
 &%%./#*%%1''' /,'#&!
 !#/'2/'%!(*%!$@!(,"'2"%&*''!"'%"'&*' &* &&,'#&&"'%"'
)&%&'&**&%%&*&%"%2%!#"!+)*)$%&&%%)&%& 1&"%
/

*@A&6****%&
$ & *# * 5  "&!1&*&%!  *'&!&&*&%"&+%!$/*+&H"&+
678('5''*&%! ($+"# &'*$''1% + &$"H) #*%)*%%&
1$%**(1$%"'!/*%)&%&'1''/*B#*!&/ &*"&'+/ &%%&*&
# %"&,"%&*")&,$&!!#*%& &#!+%!*&' &%$%&&*&' &
 &#!+!*#))'"&%  &$%)# ' &&# (1**',%&(1''/    !%!"%*$!
)**& #/3"&)*&")&%%& &#!+
)"'*&%! $+/  "&!1& 5%**&&%()*&"#'*'+%&&1* &15 
&*)+>+!%88?

%2&*$ &+!&*&&**&% )*!#"&, 1%&&& &+)*'*$% 
 &/'1&'%2&*$#  **(,%&!"#$%&!"&,%  &**&%"*$
4.%&&*&$%&"%(&/%&.* 5$%& JH) #*&&*&$%&1&
&**&%*,"' "% !*!&/) &,
%+ #/3"& *&! "%&%# .*)*&")&%%& "'%"'&*'&%+&$%!*
1&,** %( )"!*#% )"!(1&#&%+ )*3#!"0"% &*%& *&/
$) !%& #/3"&(%!1%))*)*&( #/3"&$+/&*&!1&&*"%,%&%'
&*)+1%"'%"''+%!"&!
0%, ,$&! 1''/ # !!#*%& &*'
#/3"& 1''/''1!*#'*'+!#*%&&*'( )"''+*!,* ,%& ())*H$&'+
%"$%&*$%& 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
 
6% B#%&'+(/ !%,'/' &+!&%!&)*) !&*'! %(% &+  # 
&* &%& *)*&!*H)"&!''1%&)"'!$% &*&%&**&% "*$
//
 '; !6
	&%! )'+"%&*')*&%&&*&$%&"%!#&&*5*&'+&""&,&+%!
$!#'&%)*'*&%%!!*%&&% 5*&%"+& '!%&&'$%&%
"$!% >1%?
	&%! H*&&*"& %$'"#'*','&*#%#"'**")&* :	&%""!
	")&*>		?%!	&%"=	")&*>	=	?(1"",&* #/2&+) ( %!
/
!*#!&
$!&$
**&% "*$4.1%))'!%"!'+*15  /% 1%&/ %!
"&,%&&*&$%&"%,#'* (1&;2))*,'*"$$*"'# *%&!%
9"&/*8 >))%!H E T-;* "*/%-%*$&%?
"$$*"''+2))*,!&**&%! %*$%1''/# ! & ,'#&""+%!
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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
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(%!
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI
CCI
CCI

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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2
Approved
7.0
CCI

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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2
Approved
7.0
CCI

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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2
Approved
7.0

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$'%% /+ /'"5% & &*% "*)&%  &+* % ( %!#"% ! B#$&%( ! )* %
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CC
I

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&%+)*&")&%%&"'%"'&*'#/3"&#%!*&,% %!%  %&
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%!)& *"''"&!(
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%!   1''% &  * )* %' %*$&% %! !&(   ,*! /+  %%  1*&&%
#&*@&%&& "*%%, &
8
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!*&&, & "!#'("%"$&%&&*)+)*/&% (%!$# &/"$)'%&&&
&*&$%& >*  #/3"&  1 * $%* ( & )*%&> ?.'' *)* %&&, $# & / ' 
1''%%!/'& ') & #/3"&"$)'+1& &#!+*B#*$%& ?
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
F 
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=#'*!&  $
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
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/% &/'*&' &$%& )**&&D '%, &(
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"%&*&$%& >*H$)' '"+'""!&*&$%& .&*% !*$'
"%&*")&, **/!!%# !&&*&"%?
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	&%! >%"'#!%H!!*#"$/%&% ?
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! B#$&%(*/* ,%& (! ,"'% % &*) ?
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%&*&"'*!*$'))'"&%&! &%"*$&"?(&&*"+"'% (&*
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9*'*&%! . &*&%%
$%& 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
F 
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$%& 
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F$%& 
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F$%& 
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$%&
0&: 0&$*$)*!  )"!*$!"&! ,%"*$ (&*2 , ("'% ( &*%%& (*)*)*&% 1&
'"'(/#&&*))'"&% )*/&!!#*%& &#!+

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* #*"'%&*,%&% &&(%&)%%&%, &&*($&)#&& #/3"&&* 5(
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/

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& #/3"&(%!1%))*)*&( #/3"&$+/&*&!1&&*"%,%&%'&*)+
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"'%"' &#!+!$!&/%"  *+
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&*)+* .*
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
F7 
	$(+

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)*"!#*! "*/!%"&% F
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&H&;*$
-* %*! "%&%#&% O1&!*1'/+ #/3"&P (O1&!*1'/+)*%&.#*!%P(O)+ "%!" %P *
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* %> ?*1&!*1' 1''/!"#$%&!%&6	;#/3"& 1,/%
*%!$@!1''%&/*)'"!/+%&* #/3"&
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
F 
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 &#!+, & * &+)#*)  %!*"''"&%&' &&!&*&)*$*+%!)%&(
/* &#!+H&
<% #/3"&! "%&%# & &#!+(. 1''/#''+    !1%,*)  /'(%!
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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
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%!$#"# $$/*% ?
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
 
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1&%"'%"''+,!%&"%>% )&*'"'@!&*&$%&?9%)#$)"&#&% #'!/
%#&",*&*!(*&"5('&"5(% (%!"%,!))'"&%%."' 
&+ (*%' &$#&(') %!$#"# $$/*%
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#%!&%
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
 
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%+&*)*$&&! 5%"*)*!#"& >" $&")*!#"& ?
*!#"& "%&%%'"'(')+!*H+*'+"'""! %! &*%%&  #'!%&/# !
!#*%& &#!+
;" ,% ''1!!#*%& &#!+ 
' #/3"& 1&H"  ,"'*&&1#'!
%&**1&"%    $%& ( 3#!!/+&%, &&*(*%&'/'&)*&")&%
& &#!+
' #/3"& 1&"'*1''/H)"&!&5)* 1''2*$!)**&
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#/3"&  #'!1 &*"%!*$,''$5#)&' &F$%#& )**&"
 "!#'!"'%", & %!  #'!%&))'+%+&*&)"')*!#"& &&"*+*#%&'
& &#!+, & /%"$)'&!-  #/3"& **, ,%%&*$,!''$5#)( #/3"&
1''/*B#*!&*$,&* !#'$5#)&&"'%"%!1&&' &F$%#& )**&
)*"!#* 
#/3"& 1*1*%"$ 5 #'!"%&%#&! #%&' &!%%H$*$(%
""*!%"1&+#*'"'#!'% 
 5*$,' *B#*!*&%, &&*&)**$
& &#!+    $%& 
&*)! #/3"& 1''' / 5!&*$,''31'*+(+1*%!)#''*/"5*$
&*"()**& &#!+$%

$#@$;&;$&-$(&;
&#!+$!"&%1''/%!,!#''+'/'!>/&&')#$) *&**&%.,"'?%!
  $/'!%&5& (*  #/3"&  %$%&*!#"&))*%"()"5%%!'/'%1''
% #* #/3"&%!"'%"' &/'%!%
" #/3"&1'',))*H$&'+7! )% %)"5 )*5&(")"5"%&%%)#$) 
&! )% ""*!%&& "!#'    $%& >D '%(<5( <5(<5(
<5(<5 %!H&*? C1,*%'+/&&'1''/! )% !&"! )% %
%&*,'H&*/&&' %" & #/3"&'  **#% #&-#/3"&  #'!/
% &*#"&!&))'+&-!'+&&*"*15 

'-5 '; $&$;%&
12

)
&#!+!*# $# &/ &*!% %! "#**1&* &*"&!""  (#)%*")&%!
&*##&& &#!+ 	*& &*"%!&%   )"!%"&% E &#!+*#
 "*)&%
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
F 
&* #'!/&$)*&#*$%&*!!'+(%!&$)*&#*H"#* %""#* (&
! %&!)* %%' #'!)*$)&'+%*$& &#!+$%&*(  )"!%&"#**%&
,* %&)*$"+$%#'
12/
""
	&	
)%*")&& &#!+!*# (& &$# &"%!#"&"$)'&%,%&*+'' &#!+!*#  -
!$! )$%& *",!%!.*&$)*&#*H"#* % /%H)*%"!(& &
1''%&+&)% *.6	9%!''1&#!'% ""*!%&&"#**%&,* %&
)*$"+$%#'
'' &#!+!*#  %&&&-%, &&*.-% &&#&%1''/""#%&!*%!%#%#&*@!# 
 )*$&&!#/3"& 1''/% &*#"&!&*&#*%'' &#!+!*# %!! %"'%!* )*&
"!#'    $%& >"&%? &*,1# %!! %"$)'%"#/3"& 1''
/"#% '!%&$)*&%"''1% &#!+!*# ! %% &*#"&% 
%, &&**! %1''$%&%""#*&*"*!  #))' *",!(%,%&*!&
&"'%"'&*' &%!# !)* #/3"&  !%!#%# ! &#!+!*# 1''/))*)*&'+
*"%"'!/+&$%&*%!*&#*%!&&)% * *! % *! &*#"&% % &*#"&!
/+&)% * >"&% F E  )% %%!	&#*%&#!+*#?
120
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 %&! &#!+)* %%'&"%, &&%' &1''/* )% /'*! )% % %!
*&*,% & &#!+!*# &&))*)*&, & +1''' *"*!&! )% % %!
*&#*%% %*$&%*" #/3"& > "&% ?
" #/3"&1''*",  &#!+!*#&D '%(<5( <5(<5(<5(%!
<5 , &  &#!+!*# 1&%"5&1''/#%B#'+!%&!1& "** )%!% 5&
%#$/*%!/&&' !%&*&!"$)'%"    $%&()*! %%&*,')%
! )% %(& H!)*&%&'/'1''*$%%&! )% %/H&*2
)*&%&'/' &/*$,!*$&! )% * %!&&"!&&))*)*&!*#
""#%&%*"*!
" #/3"&1''/% &*#"&!%&$)*&%"*&#*%%&* &#!+!*# ># !%!.*
#%# !?  )"!%& "!#'    $%& >"&% ?*#""#%&/'&+%!
! %"$)'%"1''/    !/+&! %&! & )* %%' #/3"& 1''/% &*#"&!
&*&#*%&! %"'%!*%!'' &#!+$!"&%&" &#!+, &(**,1/+ &#!+
)* %%'%&)* %"& #/3"&& &#!+, & <5%!<5( &#!+!*# 
! )% !&D '%1''/*2! )% !&*"$)'%"""5 *"$)'&!> "&%
E *&$%&6$)'%"?
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
 
-%&,%&*'+&*$%&%. # )% %&"'%"'&*'(*)!*"'' &#!+!*# 1''
/%&&!-%, &&**! % $# &$$!&'+% &*#"&& #/3"& & &)& &#!+
!*# %!*&#*%''  &#!+!*# &&"'%"'&*'"%&*
;* #/3"& 1!%&"$)'&&%&*"'%"'&*'(''# !%!#%# !  &#!+!*#  #'!
/*&#*%!/+& #/3"& &&"'%"'&*' "%&*
&&"%"'# %& &#!+(&# !%!#%# ! &#!+!*# 1''/*&#*%! &&)% *
*! % %"*& &#!+!*#$%$%&
121
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& &#!+!*# %!%%2 &#!+)*!#"& 
! %"'%!* 1''/)*,!!&& #/3"&1&"'*!*"&% *"$)'&% &"
! )% % , & >"&%?#/3"& 1''*"*!!'+# &)"' &#!+!*##/3"& 
1''/% &*#"&!&*&#*%&! %"'%!*%!'' &#!+$!"&%&" &#!+, &(*
*,1/+ &#!+)* %%'% &)* %"& #/3"&
"$)'&!! %"'%!* %"&' &, &1''/"''"&!( &", &''1%
#!'% )*&%&&*&$%&"$)'%"    $%&:

	!8#$*'-5- '; 9*'-5# $%::*&$%&"$)'%"1''/    !# %&
 #/3"&! %"'%!*(%!!*,!*$&&&'H)"&!!  %!%#$/*"&#'
!  *"*!!%&! %"'%!* >/ !%6	;!&%&* ?(,*,%, &%&*,'
-%!,*&%&$  !!  &)"' &#!+!*#1''/"% !*!)*&"'!,&% ( 
"%*$!/+! "#  % 1&& #/3"&&**,1%& ! %"'%!*(%! #/3"& 
 #'!/))*)*&'+"#% '!%&$)*&%"''1% &#!+!*#! %% &*#"&% 
#/3"&   #'! / *$%!! %! %"#*! & ''1 #!'%  * %%2 &#!+ )*!#"& # (
&*##&& &#!+>"&% E -% &*#"&% * ?
D
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)% %&#*&-6;(" #/3"&1''/  %!#/3"&-!%&"&%0#$/*>-0?
&/# !&*##&& &#!+9%"-0 /%  %!(&&%#$/*$# &%&/# !
%*%+&* #/3"&#/3"& $+/*2 "*%!%")*,!!&* %**2
 "*%% %&*'&!&-C ,*&+>9?("% ,*&+ >-? *"%' %"#%& 
	%!$@&%1''/ &*&!/+ &#!+"%&* # %&-	 + &$)%"%*$&%
 #/3"&'/'&+(&-	1''/# !&  %&/'%!! &#!+!*# *%!$@&%
"! 1''% #*&&*&$%&  %$%& *%!$%! ''"&!%%,*''
*&(
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
 
"&,&,"'	*&"&% *%''# &*&%& &#!+! %%!&*&$%&
''"&%
0
!*!-6#$!&
- #/3"&H)*%" )*  &%& 5%!*+%  ***&&%(&-%, &&*$+"% !*
*!#"!))'"&%*B#%"+*&&)"' &#!+!*#%&* & 15 & &#!+(*
$H$#$!#*&% 15 #/3"&  #'!/% &*#"&!&")&#*''$  !&)"'
))'"&% %&! %"'%!*& 1''*"*!&&$%%!!&' )* "*/!! 
*!#"&%*&)"'$!"&%% #*"*"*! 
% %! +$)&$ '"'"#&%# **&&%1''/"% !*! !,* ,%& &+
* ,*%#&'!&)*$%%&! "%&%#&%&)"' &#!+!*#*&+*B#*
&# "%"$&%&&*&$%&%"'#!%96 )*!#"& >&*&% $ &#*@* ?	*&
"&% F *#*&*!&' %'"'&'*/'&+    $%&
,
!#$!&!&#$%&$&-&-&;
#/3"& 1''/"%&*''+*%!$@!# % + &$/ !%-%&*"&,	 )% "%'+
>-	?''"&%"%"'$%&1''/% #*!( & + &$1''%&*' &*%!$@&%
"!#%&'& #/3"& /%*"*#&!%&&&*'(1"&5 )'"&*''%"'# % .
H"'# %"*&*,/%,'#&!	%!$@&%1''""#*%!,!#''+ 
*%!$@&%"!1''/  %!&&#%B##/3"&-!%&"&%0#$/*>-0? "
*%!$@! #/3"&%!& $#'&%# *%!$@&%*#)  #/3"& 1''/)*,%&!
''&&$)& 1'' /$!&5)& &#!+ &  & %! #/3"& /'%!!& &#!+&*&$%&
&*##&& &#!+
$/* & & &1''%&,""  &&*%!$@!&*&$%&
  %$%&"&, &#!+$!"&% 1'', $'*))*%"()"5%%!# % &*#"&% 
 &"** )%!%,"'
+
&(&-&;' &;)&#$'-5
&&%&&%& &#!+( & & 1''/% &*#"&!%&$&!&''1*$*%"+
/*5%&/'%!*%!$@&%%*$&%*%+)*&"#'* #/3"&$+/$!
,'/'&&%, &&*%&,%&$!"'$*%"+*%&&%"  && 
!%&"&%& &#!+!*# *&1'*&&)*&")%&<%,*)  /'(&
%, &&* #'!"% #'&1&&$!"'$%&*%!&)% */*/*5%&/'%!(
&! "#  &!" % $*%"+#%2/'%!%!#*%&"'%"'&*'$+/ *B#*!*
*#'&*+* % >*H)!&! &+*)*&%?
<%&/'%!%"! /*5%(&!&%!* %$# &/#''+!"#$%&!  #*"
%&$# &' %"'#!*"*!&! "#  %1&&
!"'
%&* -&"! /*5%
/+&%, &&*(& #/3"&$# &/1&!*1%*$& &#!+ &*"$)'&%*'+
&*$%&%)*"!#* 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
 
-%, &&* & ' * )% /'&+*!&*$%%#%/'%!% #/3"&J  &#!+
&*&$%&  %$%& 1**%&! #/3"& &+$# &'1+ /&* &"% !*&%%
$5% #"!" %-& -%, &&*!"! &&#%/'%!% 1**%&!(&-%, &&*
 #'!$5,*+*&& "%&"&&
!"'
%&*)**&#%/'%!%  #/3"&J  &#!+
&*&$%&  %$%&#%'  & "#'!!'+$*%"+&*&$%&&  #/3"& -&  %&
)  /'%!& &#&% %$*%"+&*%")'-%, &&** !'&!!)#&+$+
/*5&/'%!%!"%&"&&$!"'$%&*   % )  /'&*&* ))'"/'
)% *  &%!*!)*&%)*"!#*>9?1''/''1!*/'%!/*5%
 ,! / %! & % #* & %&*&+ & /'%!( )* %%' !*"&'+%,',! 1& &
%% "%!#"&  &  &#!+*$ & )% *( 6	9( * &* %, &&%'  &#!+"%&* 1''
%&,""  &%+ %*$&%&& $+ '!&#%/'%!%
*%!$@&%"!1''*$%/'%!!&'' &#!+ & %! &#!+&$$$/* #%&'
"$)'&%& &#!+( %!&*& &#!+!&/  /%'"5!
++
!&.&<*;$!&$'-5'88*
)% * *! %1'' #))'+&''1%%%2%, &&%' #))' %"'#!%:

6&)'Q %&'5%6'% *

6&)'Q *$"%&*' 
 &#*@*;F

6&)'Q 
 &#*@%&%
'&*%&,"'% *%!$ &#*@* *%&)*$&&!(%'+& #))'!%%2%, &&%'
)*!#"& /,&/# ! 	*&#!'% *# %&"'% *%!$ &#*@*
>"&%  E -% &*#"&% * ?)"'*&%! *5%1%&%!#" 5%**&&% %!
# $ &#*@* #'!$%$@**&&%%!%%""$)'%"1&# %&&)"'
 &#!+!*#
)%*")& %%2%, &&%' #))' (& &$# &"%!#"&% %,%&*+''%%2
%, &&%' #))'  -!$! )$%& *",! %!.*&$)*&#*H"#* % 
/%H)*%"!(& &1''%&+&)% *.6	9%!''1&#!'% ""*!%&
&"#**%&,* %&)*$"+$%#'
%, &&**! % #'! $%&%*"*! %%2%, &&%' #))' *",!
%!! )% ! $%&*1''"%*$'/'""#%&/'&+%%2%, &&%' #))' 
>&&'*",!%!! )% !?
& 1'' /)*,!! &)%!& '"''+  #*"&*1%#*%)*%%"+& &5& *# %
& &#!+
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
7 
+
 ! $&-!&#!%$& 	) $85
1/
)			
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*,# &*) *!%! $!"&% *)*"!#* &&,/% &))!/*&
"*%%, &%!%"'#! ''"%&*) >1&%$%& ?%!''&*&*) >1&%
$%&?
6%"$&%&&*) *!%! :
 %+H &%&*) %%&&"*%%, &(
 %+"% &H &%&*) > #" "% %! **$#'&%?!#*%&"#* 
&"'%"' &#!+(*
 %+%1&*) *",!/+& #/3"& %"&"*%%, &
%+%1"%"$&%&&*)+*$!"&%%H &%&*)+$+/'%5!&%!,* 
,%&>?"** )%!% *$$# &/"$)'&!&""#%&*&"%%&*)+(
H")&% $"   #" &*)+# !*)*)+'H (! $!"&%*"*%"
"%!&%(&" -%& "  (&$!"&%1''/'%5!&%&$%&$!"' &*+
1//

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''1%&1"&* *&/"% !*!*)*,# %!"%"$&%&&*) :
 *# .&*) %"'#!%(/#&%&'$&!&()* "*)&%(,*2&2"#%&*>96?(/*&
"%&*')'' .)&" .*$%'!," (,&$% ("'% * ($ &#*@* ( #% "*% (*/'
$!"% . #))'$%& (%!$)&")*)*&% 
 
!"'%! #*"')*"!#* %"'#!%(/#&%&'$&!&(' *.*!&%)*"!#* (
!*$'''* (=2*+ >H"'#!%!%&'=2*+ ?(&"
1/0
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>* !*# .&*) ?%!.*%&
!"'%!#*"'*"!#* *$>*$!"'. #*"'
)*"!#* ?%&" *)*&*$>6	;?
6%"$&%&&*) *&/*"*!!(*,1!(%!#)!&!&", &,*+&&$)&
 #'!/$!&5)"%"$&%&&*)+! %%!*$%"% &%&!#*%&&*'
'&*%&,"'% *%!$ &#*@* *%&)*$&&!(%'+& #))'! %%2%, &&%'
)*!#"& &/# !
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
 
1/1
	45	"
	6
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#&*@!(%"'#!%&''1% '% &+*%&%!"&!*&&*&$%&"%
,#'* 
)"')*!#"& :
''1%&)"')*!#"& *#&*@!%&&*&!* :
 6&)'Q %&'5%6'% *
 6&)'Q *$"%&*' 
 &#*@*;F>%"&&)"' &#!+!*# !*!?
 6&)'Q 
 &#*@%&%>%"&&)"' &#!+!*# !*!?
+ &$"&*&$%& :
''1% + &$" $!"&% *)*$&&!&+*%&%!"&!*&&*&$%&
"%,#'* :
 # %%2 &*!'%&2%'$$&*+!*# >0- ? "")&/'*#)& !+ 
>"#$#'&,?&*&$%&L1,*(& #'!/,!!!#*%&215 )*!)**&&
%' &#!+    $%& ><5?
 )"'%&/&" )* "*/! *'"'@!!*$'%"&% 
 %"''%*
1/
		5	"
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!"&% .&*) ' &!%/' *)*/&!!#*%& &#!+ &+$+%&**1&
""+%!.* &+    $%& 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
8 
	$(
*!6 !)(--#$!&*A	) $8*' &;'-5
	!8#$ $%&* !&)6$#:
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"%&%%&*&$%& (&*%&2"%&*&$%& *&*"%&*&$%& >( '"+'""!&*&$%& ?
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&)"')*)*&% 
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6*&" &*! >H")&'"''+"&%"*&" &*!  #" %'!*%&*&"'?(%&/&" >H")&
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* "*)&%& & &*%&*)+>(& & &*%"+)%&(& & &*%%%&&(& & &*%)''&(
& & &*%#%!"%&?*%& & &*%/ &**)* "*)&%& & &*%>(C(9$%!*%Q(
# &%%Q(& & &*%"+)%&(& & &*%%%&&(& & &*%)*)%&(& & &*%
)%+')*)%&?*& & &*% #))'$%& >( */#'# ?
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%&"#'%& %!
&H+'#*&
) 
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%+!*# >&)"'* + &$"?*)*"!#* &&*# !'/'*&&*&$%&"%,#'* 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
 
-)*/&!&*)+/"$ %"  *+*& &+& #/3"&(&%, &&* #'!
%&+&$!"'$%&*%!! "#  )  /''&*%&, - #/3"&*", )*/&!
&*)+!#*%&"'%"' &#!+>(%!,*&%& *&2&*$# ?(&%, &&* #'!' 
%&+&$!"'$%&*%!! "#  1&**%&& ))*)*& *& #/3"&&"%&%#
*",% &#!+!*# 

' $!&!6'("#$ #8$!&
H)"&!!#*&%*" #/3"&J )*&")&%%& &#!+ ))*H$&'+7 $%& >
15 >$%& ? &*&$%& %!#)&2!+ )*!/&1% "*%%%!/ '%?
+
$ 5	 %&$!&3*
<% #/3"&! %&"$)'&&"'%"' &#!+(. 1''/#''+    !( #"
    $%& )  /')*"!#* ! %&!*&<5.*'+*$%&%, &
 #'!/"$)'&!*'' #/3"& ! "%&%#%& &#!+ %!&))*)*&6	; )
 #'!/"$)'&!
	*&"&%F ** % **'+ &#!+! "%&%#&%
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#%)'%%!%!$+%"'#!H$%&% * &+**)& &#!+    $%&  & 
""#**%#& !&, &1%!1*%&"% !*!#% "!#'!, & 
    $%& &/"%!#"&!&&#% "!#'!, &1''!)%!%&* %*&, &:%+
&)*"!#* .    $%& ' &!%"&%  "!#'    $%& $+/
"%!#"&!( ))*)*&

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""*!%"1&+#*'"'#!'% %*' B#%"H$%&%  #'!/%1&
1''%      $%&(*,1! %"'%!*."$)'%"%!"$)'&% #/3"&
B# &%%* )**&)**$%"%    $%& >-(' %"#%& ?('"'&'*/'&+
    $%&%!$%>*! %&!$%"%&* ?
%+"'/ *,&% "'*'+3#!!/+&%, &&*&/*'&!&&$ 5>
*+&$*!*$&&""& ?1''/%&!% #*"*"*! %!%"'#!!%&6	;
"$$%& (&&*/#&/'&&$ 5>(%"* !*+&$'%$ 5!(&"?%*$
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
 
"%/ #/$&&!&&! "*&%&%, &&*-$ 5"& *$%!&"&/'&&
&$&"%    $%& %! '"'&'*/'&+    $%& (&+ #'!/"% !*!%!
*)*&! )*&&     $%& 
	*&"&%E "!#'    $%& *#!'% &% #* &+%*''!
 #/3"& %!"%&%#&+ "!#'!''12#), & 
+
66#$#5****%&*
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 #/3"& >* #/3"&2*)*&!     $%& ?""*!%&"&% 2 "!#'
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,'#&* $# &"$)'& &%!*!@!&*%%)**&)**$%&''1%     $%& :
9,*''  ,*&+C+)*)$%&&%(
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* %%'*%% *#*&*!&' % &)* %%'&*%%"% ,*&+*!%>-? %!
' %"#%& 1''/)**$! )*&'+"% ,*&+    $%& 1'' /)**$!
/*&' %"#%&%
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-%, &&*)**$!"&,& :
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9,*''  ,*&++)*)$%&&% "* >82)%& "'?*$>6'*?&
>,*?&"*%%(D '%(<5((%!**'+&*$%&%, & 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI
CCI
CCI

	
	
		
 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
F 
++
< $*$*< 5 #$
	$(
< $*$*< 5158 8;%&$!&
 $-&;#$!6'#!%$*' *
*!
9,*''  ,*&+

0*$'
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>*$ (?
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
7 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
8 
/
$65****%&*
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/
!#$	! $(5****%&
"'&'*/'&+    $%&> ?%&"1''%"'#!*+&$( "'%(!*+%  %!
/#*%%. &%%&, &  )"!% & "!#'    $%& >"&%?/'8
 #$$*@ &'"'&'*/'&+    $%&D#*%%. &%%1''/*"*!!/+&
%, &&*&*! "#  %1&& #/3"&
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
 
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)*$&*(/ !%"'%"'3#!$%&&%, &&*
	$(,
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 5)%$E $(&! %$ -&**!6)*@&
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-%&% *!%  
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*5!*#%  
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 ,*&+" %%! +$)&$ #'!// !&*&' &&)"' &#!+!*#
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$!"&% >&*&%$ &#*@*?
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
 
%+%1 %* +$)&$(1" %&%"'#!!%& "!#'!,'#&%&'*/'&+(
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/
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&/*)*&!%&!,* ,%&;*$1&"$)'&%*$&% *B#*!- ""#*(
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$# &/)*,!!1&&%$%!)%%#$/*"'%"'&*'"%&*)* %%'**)*&%
 %!$!"'$*%" 
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# ( %+%1 %( +$)&$*!  (*%+"'%"''+ %"%&1* %%%H &%
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&%&%&%

!"'* #*"')*"!#*>(%! ")+())%!"&$+?:&"%!&%&&'! &&
)*"!#* &
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
 


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*$&  *# !,* ,%&>? %+#%&1*!$!"'""#**%"&&:
 	 #'& %!&(
 - '2&*&%%(
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 	 #'& %)*  &%&* %"%&! /'&+.%")"&+(*
 - "%%&'%$'+./*&!"&
-$)*&%&$!"',%& &&$+%&* #'&%!&(/'2&*&%%(**B#*
 )&'@&%$+/"% !*!%1%(/ !#)%))*)*&$!"' 3#!$%&(&+
$+3)*!@& &+& #/3"&%!$+*B#*$!"'* #*"'%&*,%&%&
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"%,#' % &&!%&* #'&% )&'@&%
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1* $* ,*
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&& )&'C )&'@&%$+%&"% &&#& #"%&*#%! &/"% !*! %
&  ''+*&)#*) !% &"& & >,%*'&!&%?('"&, )&'@&%
*%%&*,%&%&&1 '*!+)'%%!/* #/3"&%*''$%&%&"'%"'&*'(
!$  %&!+2"*"'&+( "'!$  %>(& #/3"& %)'"& ')?(*
!$% &*&,!$  %>(*+*'+H$%&%?
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	
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))*)*&*&)% *&$%&*"' '+-&"#'!/ *# *%%2 *# %!- 
"#'!%"'#!,%& &&$&/)&%&')*"#* * *)*!*$' +$)&$ *$* *# 
$!"'"%!&% % # ")&/'%!,!#' 
 )"'-%&* &*& )*&"'*)*2!%! ''1 :
 *+&$( "'%(!*+%  ( &%%./#*%%(%!&**'&!"#&%#  1"'!&
)*$%%&&*&$%&! "%&%#&%
 # )"%''*""%&"&*"&%*'&!&& &#!+!*#>  "&%F?
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
F 
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%%2 *# ""*!%&&# #'*#'&*+"*&*
;* # )"&! % &@&%   "&!1&&)"' &#!+$!"&%# (''1&*"''%
1&  %!&)"' &#!+!*#)&"& &)*"!#* %"&%F >%! #/ B#%&
%*!%&)&"& &%(&*"''%1&  %!&)"' &#!+!*#  ) &,*
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%*$&%*%+ &+%*$&%&&))* &/!*#2*'&!%,',% #/3"&1 
)*&")&!%"'%"'&*'(,%&* #/3"& "$)'&!&"'%"'&*'
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))*#%&'$!"&% /%! "%&%#!
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-%, &&* &"'  +&%&% &+ # %&''1%!%&%  #!'%
*'' ;*& "'  "&%(&-%, &&*1''&5%&""#%&&)  /'*%
&%&% &+&,%&%!*)*&&*!%&% &+1" &$ &))*)*&
""*!% $!"'3#!$%&

'!
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!*&
 "$*&(%#&"# %&**%"1&# #'"&,&+
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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
 
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	
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%+""#**%!#*%&*)*&%)*!(1&*& *'&!&& &#!+!*#*%&(
1''/*"*!!$$!&'+%& #*"!"#$%&(%!! "*/!%&!,* ,%&;*$
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
 
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$&&%%+*B# &!%!5%1%%*$&%!!&%'%*$&%$+/*B# &!#%!*
"*&%"*"#$ &%" !,* ,%&     ! *'&!&&&*&$%&1''/$%&*!
#%&'&+*"$)'&'+* & "&*'+* ',!9&* 1''/$%&*!#%&'&' &
, &&+*%&* ',!* & "&*'+* ',!
-%, &&*1''/&%%!$%&%%& #/3"&J ' '')*&%%&$!"'*"*! (
%*$&%%!$!"'3#!$%&*$"''# 1   &!%&&*&$%&%!''12#)
& #/3"&-%"  *+(&-%, &&*1''"%&"&& #/3"&J )* %')+ "%*
 )&' &&/&%#*&*!&' 
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&&*&$%&*%&(%!1&*& H)"&!*%&(&-%, &&*$# &!&''1%:
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%&*%!*"*!&)**  &,%&#%&'&* ', **" "'%"''+ &/'
#&"$(1&*1&#& B#';*''12#),'#&% (%&+*H'
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
 
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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
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	%!$@!("'26%&*''!&#!+P >*$ ?
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
7 
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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
7 
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&069$!'
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
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		
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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
7 
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'$&!&(&)*&"'(-6C.6( &#!+2 )"")*"!#* >%"'#!%""+    $%&
 "' %!% &*#"&%*# & &#!+!*#?( -	(%!6	;"$)'&%
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%!
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-%, &&*'/'    $%&
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
7 
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- %! 0-' %"#%&%
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	',%& && & ! %&!&)**$ &#!+$%$# &"$)'&)&*)+&*%%
%! #/$&*B#*!& &)& 
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)*&"'
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
77 
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'!%& &#!+ ' 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
7 
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>8?%! #/ B#%&$%!$%& (%!&-6C6(%!%"$)'%"1&))'"/'
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-& #'!/$) @!&&& #/3"&$+ *# &%&*& &#!+ *&1&!*1*$
& &#!+ &%+&$(1&#&"% B#%" *&*#*&*"**)%'&+*'  
/%& &1"& #/3"& &*1 %&&'!#/3"& 1*# &,*1
1&!*11*&&%%*$!"% %& #'!%&/%"'#!!*"%&%#%& &#!+
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
78 
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*#'&*+ #&*& (*B#*!?  &#!+ #/3"& 1''/%*$!/#&& %1
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& #*"( #"  #/3"& *"*!%!&!*"&'+&&'"&*%"6	;? &&$%& #'!/
$!%!"&%&&& #/3"& ,/%%"'#!!%& "'%"'&*'%!,)*,!!
 %!1*&&%-%*$!6% %&%!   %& ))'"/''' $# &/&*#'+
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	 #'& %+!% &"& & "%!#"&!!#*%&"'%"'&*' #'!' /%"'#!!%&
 #*"!"#$%&&%
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
 
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++

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  %&'!"#$%& *& !"#$%& &&%!,!#''+ %!"''"&,'+ )*$&,'#&%
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%*''! #/3"& 1,%&"$)'&!& &#!+
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
 
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24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
 
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(&'+ )&'+"%,#'* :*"%&!&(%1#%!* &%!%
&&*&$%& #*X*$&'L:E
" %! &*#  X/"# '%!"&,&+%/'"5 5%*$&'6'%8L>F?:F82F
,*+ ($0(
	(&'	'/'&+    $%&%!,'!&%&) &"%
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*$"%,#'* X$"!*$&'X%L7>?:2!:.33!F87)#/
F9"&
-:7
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)*"#* *$)*, &'*/'&+&)"'&*&%%I:*%!$@!(%, &&*2/'%!!( )'&2"
 &#!+X*# *$&'L>8?:27
+'*6(*$ ($X(&' &%'$$&*++)*)$%&&%6#&%
!#*X#'2#
8LF>?:F28
+'*6(652D'!%;(	$%S(&' "%,#'* % 5%"'*X$"!*$&'
L> #))'?:82
+'* ( #$$* (T''+ ( &' *$&'+* 5%"'*(
"*12C''6$)% (01
R*5(0R>8?())827
 &%	(U#%
(%!&*"5	"%,#'* :&*&$%&#)!&C )*"88L;/:27
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
F 
R%06 %! 
"
"' X"%%)&%& 1& 5%"'*:)*"&"'$%$%&$X6'%*$&'
;/L>?:72
R%26( D2C*/(%!*/* 
 + -> &2%'$$&*+*+&$?X6'% &&
*$&'F)L>8?:E7
S"%*X &*& &$%$@**&&%%!)&%&'&*%") &2%'$$&*+)$%&&%
1%&*&%"%)&%& 1& 5%"'*X*# *$&'"L>#))'?: 2
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
 
+

 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
7 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
8 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
8 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
8 
 
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2
Approved
7.0
CCI

	
	
		
8 
 
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2
Approved
7.0
CCI

	
	
		
8F 
+
F8$ #@@&$**6#$!&
;&@)&*"5 5%"'  "&% / !%& 5%J #%)*&"&!* )% &&* &F&
$%#&  #%H) #*&*1%&*  %1&#& #%H) #*"&*  5%&+) 
* ''1 :
-
<&L,*+*L*!*/'%!*L/'#+ L*"5' 
'1+ /#*%  '+L%,*&% 
--
<&L*L*!*/'%!*L/'#(@'(**%+ 
'1+ /#*%  '+L&% $%$''+
---
6*$1&L*1&%++**"'*L,*+"$$%
D#*% $!*&'+L&% *!#''+
-
D*1%L&+)"'
!&**%%1& 5%
D#*% $%$''+L'1+ &% 1''

*5/*1%L$!2 &*% 5%&+) (/'"5*(', 5%
	*'+/#*% L&% )*# '+
-
D'"5L/'"5*(/'"5+ (/'"5 5%
0,*/#*% L!)'+)$%&!
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
8 
+D
#&1$ %!&F$!&*!&!'&
!*: % %&% %!#%!*&31'%*'%&*'%>%"'#!%+/*1 ?1''
%&/%"'#!!%&"#%& 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
8 
+0
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*'*
$ &<*;$! 4
""$)%+% *$)*,! * #'& &%*!%&)&"& &% *&&)"' &#!+!*#
%'!*$"'%"')*&"':
-* #'& *%+& &!%*!%& *) &,*B#,"'()' !, & #/3"& &"%&"&
 .*)*$*+"*)+ "%*#*&*%*$&%>)**)!'-($8)5*#$&-66 &)$&
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& & * #'& 
  #/3"&  #'! )*,! & )*$*+ "* )+ "% 1& & *$ ))%!! & &  '&&*
"%&%%/'%!!& &* #'& (%!! "#  1&*& *',%&& #%/'%!&* #'& -&
!" % &#%/'%!(&)+ "% #'!"%&"&&6'%"'&+9"*>"%&"&!&' 
)*,!!%&*$?
%"*'+(
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
8 
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'  / %*$! && ```````````````` > #/3"&J  %$? &5 )*& % )*&"' (
O8
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+)* % &,&+ *"&% & & &)"'  &#!+ !*# #/ B#%& )&" & &% 1  )**$!
%"'#!% "  & %!,!#' "$"' "$)#%!  >H")%& ? %! "&,  #/ &%" &&
"$)* &&)"' &#!+!*#*$#'&%)#*)  &!%&+&"$"'"$)#%!> ?
&&$+/"# %& *"&%
D"# &  &#!+ !#/'2/'%!!( 1*%&/'&*,'1""$"'"$)#%!> ? 
"# %& *"&%-+#"% !*&&5%1%&%&&& "# %& *"&% *',%&
&& #/3"&J '& &&# %!&&$+/!" ,%"*$%$%&()' ( %!& *$
&& &#!+)% * **)* %&&,/+# %&"%&"&!&' /'1:
*H' *$",'%":	)*& G)*H'"$
$* %&!& ) *'-5  9
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: $&- O&; -& *  *'*P & 5!' 
%**$;*'("#
<&%/# %  !+ +# #'! *",&#%/'%!!& &* #'& 
&--&; -&
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*%")'%, &&*:`````````````````````````````````````````&:````````````
#
 6 	

 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
87 
+,
?9 6$ !&: *# (&;&6! %$!&
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
8 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
88 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0

	
	
		
 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
F 
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0
CCI

	
	
		
 
++
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 !!#!	:
,'#&% "%2%!#"!+)*)$%&&%!#*%&*&$%&"%
,#'*  #/3"& 1&&**&%4."*$,* # ,"'"*$ ,*
15  >* %?
 !!#!'%( 
		
!&6-&$5$&-'  & !%8$&#$%&
-(&#%!* %!(,*,1!& )*&"'>%!$%!$%& ?(%"'#!%))%!" ( %!
-1''"%!#"&& &#!+  ! "*/!%"$)'%"1&& )*&"'>%!$%!$%& ?(
6(%!*',%&-6C #!'% 
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 #/3"& J &&'&1''/**!! "%!%&'0 #/3"& J%$ 1''/! "' !
'' #/3"& 1''/!%&!/+   %!%#$/* %''6	; ('/*&*+ $)' (* #*"
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& %& **#'&*+ %" *$%&$# &//&%!*$& #/3"&/*
! "' #* #/3"&%*$&%&&*!)*&+
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%, &&* (*#'&*+ %" (*&*'&#&*&+ * ,*%$%&%"  
*B#*!
-%, &&*%&#* &
*%&!0$
 
              
24-Aug-2021 00:00:00
RD.06.SPR.204245 Protocol V00 18AUG2021
Approved
7.0