Training in Central Venous Catheter Care: Effects on Knowledge and Infection Prevention Behaviors of Pediatric Oncology Nurses
Phase: NA
Conditions: Pediatric Cancer, Pediatric Oncology, Central Venous Catheter, Central Venous Catheter Placement, Central Venous Catheter Exit Site Infection
Sponsor: Fenerbahce University

Study Protocol - Study Group
Study Group Document
Protocol ID: FBU-YILDIZ-001
Date: September 12, 2025
Study Group
To determine the number of participants to be included in the study, a power analysis was
conducted.
The test power was calculated using the G*Power 3.1 program.
In a similar study conducted by Huang et al. (2020), the effect size regarding changes in knowledge
level
was calculated as 0.928. In order to achieve a statistical power above 95%; at a 5% significance
level and
an effect size of 0.928, a total of 24 participants per group are required (df=23; t=2.069).
Considering possible attrition and to ensure high statistical power, the study aimed to recruit 29
participants.
Statistical Analysis of Data
The data obtained in the study will be analyzed using SPSS (Statistical Package for Social
Sciences) for Windows 22.0.
The Kolmogorov-Smirnov test will be used to determine whether the data are normally distributed.
According to the Kolmogorov-Smirnov test, if p > 0.05, the distribution is considered normal.
If p < 0.05, the distribution is considered non-normal, and skewness and kurtosis values will be
examined.
If the skewness and kurtosis values are between +2 and -2, the variable is considered to have a
normal distribution (George & Mallery, 2010).
Changes related to repeated measurements will be analyzed using repeated measures ANOVA if
the data are normally distributed,
or the Friedman test if the data are not normally distributed.
Appendix – Output Screenshot
t tests - Means: Difference between two dependent means (matched pairs)

Analysis: A priori: Compute required sample size
Input: Tails = Two
Effect size dz = 0.9284596
α err prob = 0.05
Power (1-β err prob) = 0.99
Output: Noncentrality parameter δ = 4.5485045
Critical t = 2.0686576
Df = 23
Total sample size = 24
Actual power = 0.9916119
References
George, D., & Mallery, M. (2010). SPSS for Windows Step by Step: A Simple Guide and Reference,
17.0 update (10th ed.). Boston: Pearson.
Huang, X.L., Tsao, Y., Chung, C.-H., & Creedy, D.K. (2020). Effects of a mobile phone application
for graduate nurses to improve central venous catheter care: A randomized controlled trial. Journal
of Advanced Nursing. doi:10.1111/jan.14735