National Longitudinal Cohort of Hematological Diseases (NICHE)
Conditions: Multiple Myeloma, Acute Myeloid Leukemia, Hemophilia, Hemophilia A, Hemophilia B, Myelodysplastic Syndrome, MDS, Lymphoma, Leukemia, Aplastic Anemia, Bleeding Disorder, Bone Marrow Transplantation, Blood Disease Infection, Autoimmune Hemolytic Anemia, AIHA, Essential Thrombocythemia, ET, Large Granular Lymphocyte Leukemia, LGLL, Paroxysmal Nocturnal Hemoglobinuria, PNH
Sponsor: Institute of Hematology & Blood Diseases Hospital, China

National Longitudinal Cohort of Hematological Diseases 
- Aplastic Anemia  
(NICHE- AA) 
 
 
 
 
 
 
Applicant：Institute of Hematology & Blood Diseases Hospital 
Version：1.0 
Date：4-Dec-2020 
 
 

National Longitudinal Cohort of Hematological Diseases- Aplastic Anemia (NICHE-
AA) 
 
Background 
Hematological diseases are disorders of the blood and hematopoietic organs. The 
current hematological cohorts are mostly based on single-center or multi-center cases, 
or cohorts with limited sample size in China. There is a lack of comprehensive and 
large-scale prospective cohort studies in hematology.  
 
Objectives 
The objectives of this study is to investigate the incidence and risk factors of AA, and 
to analyze the treatment methods, prognosis and medical expenses of these patients in 
China. 
 
Subjects 
Patients who were diagnosed with AA in the investigating hospitals from January 1, 
2020. 
 
Method 
The NICHE-AA will collect basic information, diagnostic and treatment information, 
as well as medical expense information of patients from medical records. The study 
will use questionnaire to measure the exposure of patients, and prospectively follow-up 
to collect the prognosis information.