Role of Atrial Natriuretic Peptide in Assessing of Fluid Status in Cardiac Surgery Patients
Phase: NA
Conditions: Fluid Overload, Fluid Loss, Volume Overload, Cardiac Disease, Cardiac Output, Low, Cardiac Output, High
Sponsor: Petrovsky National Research Centre of Surgery

Influence of volemic status on atrial natriuretic peptide in cardiac surgery patients 
NCT protocol 05070819 
Date 15.05.2021 
Objective. To identify interactions between volemic status changes and pro-ANP 
dynamics. 
Design. Single group assessment observational open label study. 
Methods. 30 cardiac surgery patients were enrolled in study. Monitoring included 
stroke volume variation, stroke volume, cardiac output recording (Vigileo, Edwards 
lifesciences). Blood samples were taken on 8 stages intraoperatively, including 
Teboul tests. 
Statistical analysis. The normality of the distribution was estimated by the 
Kolmogorov–Smirnov test. The data were analyzed with a non-parametric test 
(Mann–Whitney U-test) to compare groups of responders and non-responders. 
The APACHE II and SOFA score values are presented as the mean ± standard 
deviation (SD). A p value ≤0.05 was considered to be statistically significant. 
Correlation analysis with continuous data was conducted using Pearson’s 
correlation test (r), regression analysis. All analyses were performed using the 
STATISTICA data analysis software system, version 10.