A New Alternative for Postoperative Pain Control Following Hysteroscopy;Preoperative Intravenous Lidocaine
Phase: NA
Conditions: Postoperative Pain, Postoperative Nausea, Analgesia
Sponsor: Afyonkarahisar Health Sciences University

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THE IMPACT OF INTRAOPERATIVE LIDOCAINE INFUSION 
ON POSTOPERATIVE RECOVERY AFTER HYSTEROSCOPY: 
A RANDOMIZED CONTROLLED TRIAL 
 
Betul AHAT, M.D. 
Afyonkarahisar University of Health Sciences  
Medical School Hospital 
Department of Obstetrics and Gynecology  
November 2024 
Supervisor: Assistant Professor Rıza DUR 
 
 
Introduction: Hysteroscopy is a surgical method which is frequently used for the 
diagnosis and treatment of intrauterine pathologies including adhesions, polyps and 
endometrial hyperplasia. This procedure can be performed at the office without 
anesthesia or at the surgery room under anesthesia.  
Purpose: This study aims to investigate the efficiency of intraoperative lidocaine 
infusion, which is frequently preferred for surgical procedures, in reducing 
postoperative pain, nausea, and vomiting, as well as the need for opioid analgesics and 
anti-emetics. 
Methods: This is a prospective review of 150 patients who have consecutively 
undergone elective hysteroscopy for various indications. The patients aged <18 years 
and >65 years, the patients with body mass indices < 18.5 kg/m² or ≥ 25 kg/m2, the 
patients with American Society of Anesthesiologists physical status >II, the patients 
with a history of allergy to local anesthetics, the patients with chronic pain syndromes, 
the patients who had long-term analgesic and sedative use, the patients with opioid 
dependence, and the patients severe arrhythmia, organic heart disease, and mental or 
neurological disorders were excluded.  
The participants were randomly assigned to the study group (lidocaine) or the control 
group (saline) using a computer-generated randomization sequence. Thus, 75 patients 
were allocated to either research or control groups. The patients in the research group 
received 1% intravenous lidocaine at a dose of 0.15 ml/kg before the initiation of 
general anesthesia and the infusion of 1% lidocaine would be continued at a dose of 

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0.2 ml/kg/hour throughout the procedure. In the control group, 0.9% saline solution 
would be used instead of lidocaine. Both the patients and the healthcare providers 
administering the interventions were blinded to the allocation. 
The primary endpoint was the postoperative pain assessed by Visual Analog Scale 
(VAS) at 30th minute, 60th minute, 4th hour, and 24th hour. Secondary endpoints 
included nausea, vomiting, need for analgesic and anti-emetic drugs during the 
postoperative period.