Association of Hepatitis C Virus Seropositivity With Breast Cancer Prognosis and Treatment Outcome
Conditions: Breast Cancer, Hepatitis C
Sponsor: Mansoura University

 
Association of Hepatitis C Virus With Breast Cancer 
NCT04090164 
 
 
 
MAY 20, 2020 
© Osama Hussein 
Mansoura University 

Participants flow chart 
 
 
 
 
 
 
 
 
 
 
 
 
Breast 
Cancer 
Diagnosis 
• 3125
Randomly 
Selected 
Cohort
• 650
Participants 
Analyzed
• 405

The Hospital records were searched for “malignant neoplasm of the breast” diagnosis. 
All consecutive patients treated at the surgery department from January 2013 through 
December 2018 were identified. The list of identified patients was alphabetically 
arranged and the data of an unselected sample of those patients was retrieved from the 
system.  
The following information were collected for all patients: name, age, hospital number, 
tumor stage information (T,N,M), tumor grade, tumor biological type, anti-HCV 
serological status at diagnosis, Hepatitis B surface antigen status at diagnosis and the 
date and status at the last hospital visit. 
Mann-Whitney, Chi-square and Log-rank tests were used for comparison of anti-HCV 
positive with anti-HCV negative patients regarding age, tumor characteristics and 
disease-free survival (DFS) respectively.  
The data from a published population-based study was used as a measurement of anti-
HCV status in the non-cancer adult female population of Dakahlia [1] and (El-Ghitany; 
unpublished communication).  Fisher’s exact test was used to compare the proportions 
of seropositive cases in the breast cancer cohort to that of the Dakahlia population. 
Statistical calculations used GraphPad Quick Calculator and GraphPad Prism© V.4 
(GraphPad Software, Inc.). 
1. El-Ghitany EM, Farghaly AG (2019) Geospatial epidemiology of hepatitis C infection in Egypt 2017 by 
governorate. Heliyon 5 (8):e02249. doi:10.1016/j.heliyon.2019.e02249