Donor and Recipient Mismatch in Liver Transplantation - Time for Reconsideration?
Conditions: Patient Survival, Graft Survival, Liver Disease (Alcoholic or Not), Liver Transplant Surgery
Sponsor: University of Jena

Date: 10.02.2026 
 
Donor and recipient mismatch in liver transplantation – time for reconsideration? 
NCT ID: NCT07250919, Protocol ID: 20-5877.4  
 
 
 
Principal Investigator: 
Pollmann, Nicola, MD, Research Fellow 
Department of General, Visceral, and Vascular Surgery, Jena University 
Am Klinikum 01, 07747 Germany 
Multi-Organ Transplant Program, University Health Network/University of Toronto  
585 University Ave. NCSB 11C-G08 
Toronto, ON M5G 2N2 
 
Supervisor: 
Markus Selzner, MD 
Multi-Organ Transplant Program, University Health Network/University of Toronto  
585 University Ave. 
Toronto, ON M5G 2N2 
(416) 340-5242, markus.selzner@uhn.ca 
 
 
Research Personnel:  
 
Pollmann, Lukas, MD, Research Fellow 
Department of visceral surgery and abdominal surgery Dortmund 
Beurhausstraße 40 
44137 Dortmund 
 
1. Background AND RATIONALE: 
Liver transplantation is the only curative treatment for people with end stage liver. Disease 
Identifying risk factors that could affect the survival of the graft and recipient is of the utmost 
importance. Gender mismatch between donor and recipient, particularly, the combination of 
a female donor to male recipient has been controversial in the past (Ghinolfi et al. 2021). 
References 
Ghinolfi, Davide; Melandro, Fabio; Torri, Francesco; Martinelli, Caterina; Cappello, Valentina; 
Babboni, Serena et al. (2021): Extended criteria grafts and emerging therapeutics strategy 
in liver transplantation. The unstable balance between damage and repair. In: 
Transplantation reviews (Orlando, Fla.) 35 (4), S. 100639. DOI: 10.1016/j.trre.2021.100639. 

Date: 02.11.2025 
 
1. Studyplan 
The retrospective database search underlying this study included patients who received liver 
transplants between 2014 and 2022.The observatory period lasted at the first January 2024 
to provide a follow up of ten years and a minimal follow up of 24 months.  
 
2. Objective and clinical data: 
1. Liver transplant recipients 
A. Recipients with a donor and recipient gender mismatch (GM +) 
B. Recipients without a donor and recipient gender mismatch (GM -) 
Inclusion criteria for studies: 
- 
Patients >18yrs 
- 
LT at the Ajmera Transplant Centre Toronto 
Exclusion criteria 
- 
Re-Transplantation 
- 
Combined organ transplantation 
 
3. Endpoints 
o Patient survival 
o Graft survival 
- 
Secondary Endpoints: 
o Rejection 
o Length of hospital stay 
 
Recipient variables 
- 
Demographics 
- 
Immunosuppression 
- 
Comorbidities 
 
Statistical Analysis 
- 
Survival analysis: Kaplan Meier methodology 
- 
Comparison of demographics:  
o Group comparison: Mann-Whitney U test for non-normal data 
o  Fisher's exact test for categorical variables and Student's t-test for normal data 
- 
Validation of results: Propensity score matching