Assessment of Er:YAG (Yttrium-aluminium-garnet) Laser-Assisted Surgical Treatment in Medication-Related Osteonecrosis of the Jaw (MRONJ): A Clinical Trial
Phase: NA
Conditions: Medication-Related Osteonecrosis of Jaw
Sponsor: Wroclaw Medical University

Wroclaw, 1.02.2021 
 
 
 
 
 
 
 
Assessment of Er:YAG (yttrium-aluminium-
garnet) Laser-Assisted Surgical Treatment in 
Medication-Related Osteonecrosis of the Jaw 
(MRONJ): A Clinical Trial 
 
 
 
 
 
 
 
 
 
 

 
 Study Protocol  
 
1. Examination and qualification of patients  
2. Taking X-ray and performing CBCT.  
3. Initiation of antibiotic therapy: amoxicillin with clavulanic acid (875 mg + 125 mg) every 12 hours. 
In patients allergic to penicillin, clindamycin (600 mg every 12 hours). The antibiotic must be 
taken 3 days before the procedure and continued 14 days after the treatment.  
4. Scheduling follow-up visits 1 and 2 weeks post-procedure and at 3 and 6 months. Assessment of 
the condition of the surrounding mucosa, wound healing, complications and overall treatment 
effectiveness.  
5. Anesthesia of patients using anesthesia without vasoconstrictor additives (Mepivacaine 3%, 
Scandodenst, Septodont). Creating access with a 15C scalpel and detaching tissues using a 
raspator with a semicircular tip (15 mm in diameter).  
Procedure:  
a. Study group: Tissue debriding until hard, healthy, lively bleeding bone is exposed using 
Er:YAG laser with parameters: 400mJ, 6W, 15Hz, 5/8 water cooling, laser tip with a 
diameter of 800 microns.  
b. Control group: Tissue debriding until hard, healthy, lively bleeding bone is exposed using 
rose-shaped rotary drills (8 mm diameter) with water cooling at a speed not exceeding 
40.000 rpm.  
 
 
 
Closing wounds with 5/0 non-resorbable sutures and taking them off after 2 weeks.  
 
 
 
Statistical analysis  
 
1. Characterizing the study sample in terms of variables included in the study.  
2. Highlighting treatment effectiveness indicators.  
3. Performing logistic regression analysis.  
4. Using the Student's t-test for intergroup differences.