Effects of Emotion-focused vs. Cognitive Schema Therapy Interventions on Emotion Regulation Deficits in Borderline Personality Disorder - Associations Between Clinical Efficacy, Brain Network Function and Local Glutamate/GABA Metabolism
Phase: NA
Conditions: Personality Disorders
Sponsor: Jena University Hospital

 
 
Borderline Personality Disorder and Emotion Regulation 
 
 
Effects of emotion-focused vs. cognitive schema therapy interventions on emotion regulation 
deficits in borderline personality disorder - associations between clinical efficacy, brain 
network function and local glutamate/GABA metabolism 
 
 
Ethiks approval 04.06.2018, last time edited 

Supplementary material - Information on assessment tools, reliability criteria and classification of 
Reliable Change Index (RCI) results 
Abbreviation 
Inventory 
Information 
Reliability 
(Cronbach's 
alpha) 
Test-retest 
reliability 
PF-TK (s) 
Patient Questionnaire Day-
Clinic Jena 
(Patientenfragebogen 
Tagesklinik) 
Standardized assessment of 
patient's case history, including 
psychiatric/psychotherapeutic 
history 
  
  
SEFP 
assessed 
with STiP-
5.1 (c) 
Levels of Personality 
Functioning Scale (LPFS) 
(Criterion A) (Skala zur 
Erfassung des 
Funktionsniveaus der 
Persönlichkeit) assessed with 
the Semi-Structured Interview 
for Personality Functioning 
DSM–5 (STiP-5.1) 
Measures the impairments in 
personality functioning (Criterion 
A); enabling a dimensional 
assessment of the general severity 
of personality pathology (English 
version: Levels of Personality 
Functioning Scale, LPFS) 
α=.94 to .97 
(Hutsebaut et al., 
2017) 
not available 
so far 
PID-5 (s) 
Personality Inventory for DSM-
5 (Criterion B) 
(Persönlichkeits-Inventar für 
DSM-5) 
Assessment of maladaptive 
personality traits 
domain scales: 
α=.84 to .96; 
facets: α=.72 to 
.96 (Al-Dajani et 
al., 2015) 
rtt= .92 to .95 
(Dhillon & 
Bagby, 2015) 
BPDSI-IV (c) 
Borderline Personality Disorder 
Severity Index (fourth edition) 
DSM-IV based semi-structured 
interview that assesses frequency 
and severity of borderline 
manifestations during the last three 
months; interview is appropriate for 
repeated measurements and 
therefore for treatment evaluation. 
α=.96 (Kröger et 
al., 2013) 
rtt=.72 to .77 
(Arntz et al. 
2003) 
EHI (s) 
Edinburgh Handedness 
Inventory 
Most widely used handedness 
inventory  
α=.95 (Veale, 
2014) 
  
IDA-R 
Integrierte Diagnose der ADHS 
im Erwachsenenalter 
Well-established screening 
instrument for ADHD in adulthood 
α=.86 (Retz et al., 
2013) 
  
WAIS-IV 
Wechsler Adult Intelligence 
Scale (fourth version) 
Well-established scale to assess 
cognitive ability in adults 
α=.97 (Wechsler, 
2008) 
  
CTQ (s) 
Childhood Trauma 
Questionnaire 
Screening measure for history of 
childhood maltreatment 
α=.94 (Wingenfeld 
et al., 2013) 
  
ERI (s) 
Emotion Regulation Inventory 
(Emotionsregulations-Inventar) 
Follows the Process Model of 
Emotion Regulation proposed by 
James Gross; primary outcome 
measure 
α=.82 (König, 
2011) 
 rtt=.62 to 
rtt=.80  (König, 
2011) 
FSVV (s) 
Questionnaire concerning self-
harming behavior (Fragebogen 
zu selbstverletzendem 
Verhalten) (modified version) 
Gathers information about nature 
of self-harming behavior, triggers, 
consequences, indirect methods 
and destabilizing factors; primary 
outcome measure  
not available so far 
rtt=.63 to .84 
(frequency) 
(Reicherzer & 
Brandl, 2011) 
BSL-95 (s) 
Borderline Symptom List 
(Borderline-Symptom-Liste) 
Self-rating instrument for specific 
assessment of borderline-typical 
symptomatology; sensitivity for 
change according to therapy; 
secondary outcome measure 
(BPD-specific) 
α=.97 (Bohus et 
al., 2007) 
rtt=.84 (Bohus 
et al., 2007) 
IIP-D (s) 
Inventory of Interpersonal 
Problems (Inventar zur 
Erfassung interpersonaler 
Probleme) 
Measures distress arising from 
interpersonal sources; secondary 
outcome measure (BPD-
specific) 
α=.71 to .82 
(Horowitz et al., 
2000) 
rtt=.81 to .90 
(Horowitz et 
al., 2000) 
FGG (s) 
Questionnaire of thoughts and 
feelings (Fragebogen zu 
Gedanken und Gefühlen) 
Assessment of borderline-specific 
cognitions; based on cognitive 
models and Linehan’s biosocial 
model of BPD; secondary 
outcome measure (BPD-
specific) 
α=.97 (Renneberg 
& Seehausen, 
2010) 
rtt=.96 in BPD 
(Renneberg & 
Seehausen, 
2010) 

SMI (s) 
Schema Mode Inventory (118 
item version) (Schema-Modus-
Inventar) 
Measures the presence and 
intensity of the 14 schema modes; 
secondary outcome measure 
(BPD-specific) 
α=.85 (Reiss et al., 
2011) 
rtt=.84 
(Lobbestael et 
al., 2010) 
YSQ-s3r (s) 
Young Schema Questionnaire 
(third version, short form) 
Measure of early maladapative 
schemas (that are theoretically and 
empirically linked with personality 
disorder features); secondary 
outcome measure (BPD-
specific) 
α=.70 to .91 for 17 
of the 18 scales 
(Kriston et al., 
2012)  
rtt=.70 to .89 for 
17 of the 18 
schemas 
(Phillips et al., 
2017) 
BDI-II (s) 
Beck Depression Inventory-II 
(Beck Depressionsinventar-II) 
Assessing the intensity of 
depressive symptoms; items are 
congruent with the depression 
criteria of the DSM-IV 
α= .84 to .90 
(Kühner et al, 
2007) 
rtt= .78 (Kühner 
et al, 2007) 
SCL-90-R (s) 
Symptom Checklist-90-Revised  
Evaluation/Screening of general 
psychopathology within the past 
7 days 
α=.96 to .98 
(Franke, 2002) 
rtt= .69 to .92 
(Franke, 2002) 
FEP-2 (s) 
Questionnaire to evaluation 
psychotherapeutic processes 
(Fragebogen zur Evaluation 
von Psychotherapieverläufen) 
Monitoring of change and progress 
in psychotherapeutic and 
psychiatric interventions; measures 
4 dimensions of therapeutic 
outcome  
α=.74 to .94 (Lutz 
et al., 2009) 
rtt=.69 to .77 
(Lutz et al., 
2009) 
INEP (s) 
Inventory for the Assessment 
of Negative Effects of 
Psychotherapy (Inventar zur 
Erfassung Negativer Effekte 
von Psychotherapie) 
self-report instrument for assessing 
negative effects of psychotherapy 
α=.86 (Ladwig et 
al, 2014) 
  
 
 
Proposed terms to classify the Reliable Change Index and Clinical Significance (Wise, 2004) 
 
Reliable 
Change 
Indexes 
Clinical Significance and Normative Change Criterion 
Confidence Levels (%) 
Change of 2 SDs 
Change of 1 SD 
Change of 0.5 SD 
1.96 
95 
Recovered 
(+) Response 
(+) Minimal Response 
1.28 
90 
Remitted 
(+) Response 
(+) Minimal Response 
0.84 
80 
Improved 
(+) Partial Response 
(+) Minimal Response 
-0.84 
80 
Mildly Deteriorated 
(-) Partial Response 
(-) Minimal Response 
-1.28 
90 
Moderately 
Deteriorated 
(-) Response 
(-) Minimal Response 
-1.96 
95 
Deteriorated 
(-) Response 
(-) Minimal Response