The Study of the Relationship Between Sleep Pattern, Attention Performance, and Heart Rate Variability Among Night Workers.
Phase: PHASE4
Conditions: Circadian Rhythm Disorders
Sponsor: Tri-Service General Hospital

The study of the relationship between sleep pattern, attention performance, and 
heart rate variability among night workers.  
 
Document Date: 2023-01-02 
 
 
 

Background: Circadian rhythm sleep disorder is often seen in shift-time workers. 
The study aims to identify the association between sleep pattern and heart rate 
variability among night workers. The effectiveness of interventions with ramelteon 
agonist for their sleep quality, fatigue, anxiety/depression will be evaluated.  
 
Methods: We will provide melatonin agonist ramelteon for 61 subjects those who 
agree to participate and meet the DSM-5 diagnostic criteria of this Circadian Rhythm 
Sleep Wake Disorders. They will receive the assessments including questionnaires 
Pittsburgh Sleep Quality Index, Beck’s Depression Inventory, and heart rate 
variability before and after supplement with ramelteon 8mg for 2 weeks to investigate 
the effectiveness and safety. 
 
Anticipated outcome: The study will help the understanding the association of sleep 
pattern and their autonomous nervous activity among shift-time workers. The 
effectiveness of either supplement with ramelteon agonist will be evaluated. The 
findings of our study might be implicated in the plans of intervention for better 
performance for shift-time workers.