THEMBA II T-CELL Vaccine: A Phase 1/2 Study of the Safety, Reactogenicity, and Immunogenicity of Vaccination With saRNA COVID-19 Vaccines
Phase: PHASE1
Conditions: COVID-19
Sponsor: ImmunityBio, Inc.



AAHI-SC2 and AAHI-SC3 
ImmunityBio, Inc. 
Clinical Trial Protocol: COVID-4.015 Version 4 
 
Confidential and Proprietary 
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AAHI-SC2 and AAHI-SC3 
ImmunityBio, Inc. 
Clinical Trial Protocol: COVID-4.015 Version 4 
Confidential and Proprietary 
30 
Protocol Amendment_27 Oct 2022_ | VV-TMF-26655 | 1.0
Downloaded by Liza Hernandez Ochoa on 20 Feb 2025

AAHI-SC2 and AAHI-SC3 
ImmunityBio, Inc. 
Clinical Trial Protocol: COVID-4.015 Version 4 
Confidential and Proprietary 
32 
 
 
 
 
 
 
 
 
 
Protocol Amendment_27 Oct 2022_ | VV-TMF-26655 | 1.0
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AAHI-SC2 and AAHI-SC3 
ImmunityBio, Inc. 
Clinical Trial Protocol: COVID-4.015 Version 4 
Confidential and Proprietary 
33 
 
 
 
 
 
 
 
 
 
 
 
 
  
 
 
 
 
 
 
Protocol Amendment_27 Oct 2022_ | VV-TMF-26655 | 1.0
Downloaded by Liza Hernandez Ochoa on 20 Feb 2025

AAHI-SC2 and AAHI-SC3 
ImmunityBio, Inc. 
Clinical Trial Protocol: COVID-4.015 Version 4 
 
Confidential and Proprietary 
36 
Protocol Amendment_27 Oct 2022_ | VV-TMF-26655 | 1.0
Downloaded by Liza Hernandez Ochoa on 20 Feb 2025

AAHI-SC2 and AAHI-SC3 
ImmunityBio, Inc. 
Clinical Trial Protocol: COVID-4.015 Version 4 
Confidential and Proprietary 
39 
Protocol Amendment_27 Oct 2022_ | VV-TMF-26655 | 1.0
Downloaded by Liza Hernandez Ochoa on 20 Feb 2025

AAHI-SC2 and AAHI-SC3 
ImmunityBio, Inc. 
Clinical Trial Protocol: COVID-4.015 Version 4 
Confidential and Proprietary 
40 
Protocol Amendment_27 Oct 2022_ | VV-TMF-26655 | 1.0
Downloaded by Liza Hernandez Ochoa on 20 Feb 2025

AAHI-SC2 and AAHI-SC3 
ImmunityBio, Inc. 
Clinical Trial Protocol: COVID-4.015 Version 4 
Confidential and Proprietary 
41 
Protocol Amendment_27 Oct 2022_ | VV-TMF-26655 | 1.0
Downloaded by Liza Hernandez Ochoa on 20 Feb 2025

AAHI-SC2 and AAHI-SC3 
ImmunityBio, Inc. 
Clinical Trial Protocol: COVID-4.015 Version 4 
Confidential and Proprietary 
42 
Protocol Amendment_27 Oct 2022_ | VV-TMF-26655 | 1.0
Downloaded by Liza Hernandez Ochoa on 20 Feb 2025