Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep (MINDDS): A Randomized Placebo-controlled Trial
Phase: PHASE2
Conditions: Postoperative Delirium, Sleep, Anesthesia
Sponsor: Massachusetts General Hospital

1 
Nighttime Dexmedetomidine for Delirium Prevention in Non-Mechanically Ventilated 
Patients after Cardiac Surgery: The MINDDS Randomized Controlled Trial (Qu et al.) 
 
DETAILED STUDY PROTOCOL  
Minimizing ICU neurological dysfunction with dexmedetomidine-induced sleep (MINDDS): A randomized 
placebo-controlled trial  
Principal Investigator: Oluwaseun Johnson-Akeju, M.D., M.M.Sc 
Version: 12/15/2020 
 
1. BACKGROUND AND SIGNIFICANCE 
Delirium is an acute brain dysfunction characterized by disturbances in attention, awareness, and cognition not 
explained by a preexisting neurocognitive disorder.1 Although the increased mortality rates ascribed to delirium 
remain debatable, delirium remains a leading cause of preventable morbidity in hospitalized elderly patients. It is also 
associated with prolonged hospitalization, prolonged institutionalization, and long-term cognitive deficits.2-7 Patients 
with pre-existing dementia, such as Alzheimer’s disease, are especially vulnerable to developing delirium.8 The total 
healthcare cost attributable to delirium is estimated between $143 and $152 billion annually.9 In the United States, 
delirium occurs in approximately 80% of critically ill patients admitted to medical/surgical intensive care units (ICU), 
10 and 15% of patients admitted to cardiac surgical (CS) ICU.11 Most patients diagnosed with delirium also present 
with multiple comorbidities (sepsis, multi-organ failure) that significantly confound our understanding of this disease.2 
Thus, to date, no pharmacological intervention to treat delirium has been identified.2 The aging process has been 
identified as a risk factor for developing delirium. 
Normal aging is associated with a morphological shift of glia (microglia, astrocytes) to an activated state. Following 
a systemic challenge such as critical illness, these activated glia aid a neuroinflammatory state that contributes to 
delirium. The aforementioned neuroinflammatory state is exacerbated by sleep disturbances.15-17 Thus, sleep 
deprivation may be a modifiable risk factor for the development of delirium. Presently, pharmacological treatment 
with no current medication (benzodiazepines, antipsychotics) induces natural sleep or reliably reduces the incidence 
of delirium. We have found that pharmacological induction of rapid eye movement sleep (REM) and non-REM 
I-III sleep states using dexmedetomidine, can now be safely achieved in humans. Our overall objective is to 
evaluate the efficacy of dexmedetomidine-induced sleep in preventing delirium, investigate cellular and molecular 
mechanisms underlying delirium, and investigate whether recently described intraoperative electroencephalogram 
(EEG) signatures of the aging brain are associated with developing delirium.18 Our central hypothesis is that nightly 
biomimetic sleep in elderly patients admitted to the CSICU for > 24hrs will reduce the incidence of ICU delirium. 
Our intervention and control groups will be comprised of extubated CSICU patients, because their homogeneity in 
terms of surgical procedures, anesthetic management, and systemic inflammatory response represents a unique 
opportunity to study the mechanisms underlying delirium, while limiting confounding factors that may otherwise be 
encountered in heterogeneous patients found in the medical/surgical ICU. We will perform assessments of cognition 
(peri-operative), obtain EEG recordings (intra-operative, ICU) and blood samples (peri-operative).  
At the conclusion of these studies, we will have expanded our knowledge of the pathophysiology of delirium, 
evaluated a new preemptive therapeutic strategy for delirium, suggest neurophysiologically based monitoring 
strategies to reduce significantly the amount of anesthetic administered to elderly patients – and possibly delirium – 
while being certain the patient is sufficiently unconscious for surgery (individualized anesthesia care), and enable 
continued investigation into the pathophysiology of this clinically important disorder. 
2. SPECIFIC AIMS 

Nighttime Dexmedetomidine for Delirium Prevention in Non-Mechanically Ventilated Patients after Cardiac 
Surgery: The MINDDS Randomized Controlled Trial (Qu et al.) 
 
 
 
 
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We will pursue three aims. In the first aim, we will investigate the benefits of preemptive biomimetic sleep for reducing 
the risk of developing delirium in a randomized controlled trial; in the second aim, we will investigate the mechanisms 
of delirium using serum metabolic profiling; and in the third aim, we will investigate power spectral analyses of 
intraoperative and CSICU electroencephalogram dynamics. 
Table 1 shows a proposed timeline. 
Table 1: Planned Schedule 
Hypothesis 
Short Name 
Year 1 
Year 2 
Year 3 
Year 4 
Year 5 
1·1 
Nightly preemptive biomimetic sleep will reduce the 
incidence of delirium 
.. 
.. 
.. 
 
 
2·1 
Serum metabolic profiling will be sensitive to detect 
neurodegeneration of preclinical delirium 
 
 
.. 
.. 
 
3·1 
Absence of anesthesia-induced frontal alpha 
oscillations will be associated with delirium 
 
 
.. 
.. 
.. 
3·2 
Burst-suppression/anesthesia overdose will be 
associated with delirium 
 
 
.. 
.. 
.. 
 
The specific aims of this study are: 
AIM 1: Investigate the benefits of preemptive biomimetic sleep for reducing the risk of delirium in a 
Randomized Controlled Trial. 
Hypothesis 1·1. Compared to standard treatments (benzodiazepines, antipsychotics), nightly preemptive biomimetic 
sleep will reduce the incidence of ICU delirium. 
AIM 2: Investigate mechanisms of delirium using serum metabolic profiling.  
Hypothesis 2·1. Unbiased metabolic profiling will be sensitive to detect early signatures of neurodegeneration that 
predisposes to the development of delirium. 
AIM 3: Investigate power spectral analyses of intraoperative and CSICU electroencephalogram dynamics. 
Hypothesis 3·1. The relative absence of anesthesia-induced frontal alpha oscillations (a putative marker of brain 
vulnerability) is associated with delirium. 
Hypothesis 3·2. Burst-suppression induced by the age-adjusted maintenance anesthetic (a putative marker of 
anesthetic overdose and brain vulnerability) is associated with the severity of delirium. 
3. STUDY PROCEDURES  
Subject Selection: We will aim to enroll 530 patients over a period of three years into a randomized, controlled, 
double-blinded, single-site, parallel-arm superiority trial. Our primary outcome is the incidence of delirium on 
postoperative day 1 upon administration of the study intervention. To ensure that the study is appropriately powered 
for the primary outcome measure, patients will be recruited and randomized into the study until 370 patients receive 
the study intervention on postoperative day 0. Thus, patients will be censored from the study if they do not receive 
dexmedetomidine or placebo on postoperative day 0. The cardiac surgical case volume at Massachusetts General 
Hospital (MGH) will enable us to meet our recruitment goals within our projected timeline. Cardiac surgeons, cardiac 
intensivists, and anesthesiologists at MGH will identify all potential study participants. This initial care provider-
patient contact will ensure that eligible patients are comfortable with all study procedures. Once the potential 
participant confirms that he/she is comfortable with all study procedures, a copy of the consent form will be made 
available. Informed consent for this protocol will follow a two part process. First, a verbal consent will be obtained at 
the Department of Anesthesia, Critical Care and Pain Medicine pre-operative visit. This verbal consent is necessary 
to ensure that pre-operative baseline questionnaires can be administered. During this visit, the study protocol will also 
be explained to potential participants. In addition, a flyer detailing the study protocol will also be given to potential 
study participants. After verbal consent is obtained, the study team will allocate a study identification number, based 
on the study stratification schema, to the potential participant. Written consent will be obtained on the morning of 
surgery. The research pharmacy will allocate the participant into his/her assigned intervention group according to the 
randomization key associated with each study identification number. This key will be provided to the pharmacy by 
the study statisticians. All study team members, including the statisticians, and all clinical care providers will be 
blinded to the treatment group assignments. All subjects who provide verbal consent and complete the baseline 
assessment, but later decline participation in the study, or fail to give signed consent, will not be subject to any study-
related follow-up or intervention. However their baseline assessment, which has already been acquired, may be used 

Nighttime Dexmedetomidine for Delirium Prevention in Non-Mechanically Ventilated Patients after Cardiac 
Surgery: The MINDDS Randomized Controlled Trial (Qu et al.) 
 
 
 
 
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to identify factors that may predispose or bias patients toward enrollment. Patients who undergo secondary surgical 
procedures after admittance to the CSICU, and/or remain intubated longer than the 12 hours stipulated below, will not 
be subject to any further study procedures as they will no longer satisfy the primary inclusion and exclusion criteria. 
Primary inclusion criteria for patients and controls: (1) age ≥ 60; (2) scheduled for a cardiac surgical procedure 
with planned post-operative admission to the CSICU for ≥ 24 hours; (3) scheduled same day surgical admission. 
Primary exclusion criteria for patients and controls: (1) blind, deafness or the inability to speak English; (2) greater 
than 2 days of ICU admission in the month preceding the current surgical procedure; (3) renal and liver failure 
requiring dialysis or Child-Pugh score > 5; (4) follow-up difficulties (i.e. active substance abuse, psychotic disorder, 
homelessness); (5) previous cardiac surgery within 1 year of surgical procedure; (6) allergy to dexmedetomidine; (7) 
chronic therapy with benzodiazepines and/or antipsychotics; (8) severe deficit due to structural or anoxic brain 
damage; (9) surgical procedure requiring total circulatory arrest; (10) SARS-CoV-2 positive or SARS-CoV-2-like 
symptoms (i.e. fever, sore throat, new cough, new nasal congestion or runny nose, muscle aches, new loss of taste or 
smell, shortness of breath). 
Primary objective drop criteria for patients and controls: (1) Scheduled for a second surgical procedure during 
hospital stay; (2) post-operative intubation > 12 hours; (3) SARS-CoV-2 positive or SARS-CoV-2-like symptoms (i.e. 
fever, sore throat, new cough, new nasal congestion or runny nose, muscle aches, new loss of taste or smell, shortness 
of breath). 
Intervention (dexmedetomidine-induced sleep vs. placebo). After admission to the CSICU, rewarming, 
discontinuation of the sedative/anesthetic infusion and extubation of the airway, sedative medications will be 
administered as clinically indicated by the CSICU intensive care physician. Study patients admitted to the CSICU 
during the afternoon and extubated by 8:30 PM, would either receive a sleep induction dose of dexmedetomidine 
(1mcg/kg over 40 minutes) or placebo (normal saline or D5W over 40 minutes) every night throughout their CSICU 
stay. A sustained infusion of dexmedetomidine would never be administered for study related purposes. The targeted 
sleep induction time will be 9 PM. For the second start or later surgical cases, study patients admitted to the CSICU 
and extubated after 8:30 PM, but before 2 AM, would either receive a sleep induction dose of dexmedetomidine 
(1mcg/kg over 40 minutes) or placebo (normal saline or D5W over 40 minutes). The targeted sleep induction time 
will be within 30 minutes of extubation, with the earliest administration time being 9 PM. However, throughout the 
rest of the CSICU stay the sleep induction time will be targeted for 9 PM. In contrast, those patients who are admitted 
to the CSICU and remain intubated past 2 AM will not begin study procedures until postoperative day 1, assuming 
they are extubated within 12 hours of admission to the CSICU. The maximum dose of dexmedetomidine that will be 
administered for any study participant will be 80mcg over a 40-minute period at any one instance. Nighttime EEG 
may be obtained on all participants to enable sleep stage scoring in the spectral domain. The intraoperative EEG data 
acquisition system (Sedline) is a four-channel EEG device approved by MGH bioengineering. This device is currently 
used in all operating and procedural rooms at MGH for monitoring depth-of-anesthesia. For EEG monitoring in the 
ICU we will use the Compumedics Somte Portable PSG monitoring device.  
Post cardiac surgical patients that are admitted to the CSICU have implanted temporary pacemakers and are also on a 
variety vasoactive medications (including but not limited to: norepinephrine, dobutamine, dopamine, and epinephrine) 
to maintain hemodynamic stability. Therefore, the administration of dexmedetomidine in these patients will not unduly 
compromise their cardiovascular status. However, patients with active bleeding necessitating surgical intervention 
will be excluded from the study.  
Outcome measures and variables of interest. The primary outcome measure for this study is the incidence delirium 
in the CSICU on post-operative day 1. Secondary outcome measures include ICU- and hospital-delirium/coma-free 
days, length of hospital stay, 30-day mortality, 90-day mortality, and 180-day mortality. Variables of interest will 
include age, sex, years of formal education, race, ethnicity, marital status, chronic disease burden (Charlson 
comorbidity index), cerebrovascular disease (Framingham Stroke Risk profile), physical function as assessed by NIH 
Patient Reported Outcomes Measurement Information System (PROMIS-29)  questionnaires, organ failure 
(Sequential Organ Failure Assessment), length of cardiopulmonary bypass, presence of significant cardiac dysfunction 
(ejection fraction less than 35%), and sedative use in the ICU.  

Nighttime Dexmedetomidine for Delirium Prevention in Non-Mechanically Ventilated Patients after Cardiac 
Surgery: The MINDDS Randomized Controlled Trial (Qu et al.) 
 
 
 
 
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Cognitive testing. We will conduct delirium assessments twice daily (AM and PM with at least 6 hours between tests) 
beginning on post-operative day 1 using the Long- Confusion Assessment Method (CAM). Delirium assessments will 
be conducted up to day 3 or hospital discharge, whichever comes first. Patients who remain delirious past day 3 will 
be assessed until day 5 or hospital discharge, whichever comes first. For those patients who remain delirious past day 
5, assessments will continue until day 7 or hospital discharge, whichever comes first.  
Other Cognitive Testing: Cognitive decline will be estimated by taking into account the patient’s baseline cognitive 
function and sleep quality before admission to the ICU, as assessed using the PROMIS-29, abbreviated Montreal 
cognitive assessment and PROMIS-4A questionnaires scored at recruitment, 1 month, 3 months, 6 months. The 3-D 
CAM and TPS questionnaire will be administered at baseline. These questionnaires may be administered via email 
(RedCap), regular mail, or phone call.  
Blood Draws: For all patients, we will acquire peri-operative blood samples. This will enable us relate the serum 
metabolic/inflammatory profile to primary and secondary outcomes. For all study participants, blood sampling will 
be acquired as follows: (1) up to 40 ml of blood may be acquired at baseline on the day of surgery prior to the induction 
of general anesthesia (5-10ml for TSPO genetic profiling);(2) up to 20 ml of blood may be acquired at approximately 
9 am of every ICU stay up to day 5. We may apply at least three distinct LC-MS–based methods to study distinct 
plasma aliquots for each experimental sample. 
Anesthetic management and EEG data acquisition: Intraoperatively, patients will receive standard anesthesia care 
in which the anesthesiologist uses age-adjusted drug dosing information, as well as heart rate, and blood pressure to 
set and titrate the anesthetic. This portion of the study will follow a strictly observational nature. EEG will be recorded 
per clinical practice in all patients using the 4-channel Sedline EEG machine that is installed in all operating rooms at 
MGH. In the ICU, EEG may be acquired through the Compumedics Portable PSG monitoring device.  
Other data. A member of the study team will review the patient’s bedside nursing log and clinical notes in the patient 
chart. A timeline of physiological data (obtained from continuously recorded clinical data in the CSICU), sedatives, 
analgesics, as well as any patient events will be recorded for later analysis in relation to outcome measures and 
nighttime spectral sleep stage scoring.  
4. DATA ANALYSIS PLAN 
Data will be analyzed using an intention-to-treat approach defined as all randomized patients who receive an 
intervention. Continuous data will be described using median and interquartile range, and categorical data using 
frequencies and proportions. The primary outcome will be evaluated using logistic regression examining the presence 
or absence of delirium conditional on randomized group assignment. Any randomization imbalances, or other potential 
treatment effect modifiers will be further examined as covariates in sensitivity analyses. Secondary analyses will be 
evaluated using tests that are appropriate for the outcomes. We will use Pearson χ2 tests to compare categorical 
variables between the 2 study groups and independent t-tests or Wilcoxon rank-sum tests to compare continuous 
variables. Time-to-event analyses will be used to compare the effects of dexmedetomidine-induced sleep and normal 
care on mortality, CSICU and hospital lengths of stay, CSICU and hospital readmission rates. Kaplan-Meier survival 
curves will be used for graphical presentation of these time-to-event analyses and log-rank statistics to assess the 
effects of biomimetic sleep and normal care. For mortality analyses, patients will be censored at the time of last contact 
alive or days from enrollment, whichever was first. Censoring for CSICU or hospital discharge readiness analyses 
will occur time of death or study withdrawal. Two-sided P values of 0·05 or less were considered to indicate statistical 
significance. Because missing data rarely occur entirely at random, we will assess the associations between patient 
characteristics with respect to missing data. If patients with at least one missing outcome value are different from 
those with complete outcomes data, we will use multiple imputation to assign values to missing risk factors and 
outcomes in regression modeling. 
Metabolite concentrations will be log transformed to reduce heteroscedasticity of case-control differences. Metabolite 
levels will be compared in persons who developed delirium versus those who did not using two-tailed t tests. To screen 
these associations in the context of the balance of type-I and type-II errors, we will consider both FDR adjusted and 
Bonferroni-corrected P value thresholds. For metabolites meeting the less conservative FDR P value threshold, logistic 
regression analyses to estimate the OR of developing cognitive deficits will be performed at different metabolite 

Nighttime Dexmedetomidine for Delirium Prevention in Non-Mechanically Ventilated Patients after Cardiac 
Surgery: The MINDDS Randomized Controlled Trial (Qu et al.) 
 
 
 
 
5 
values. Metabolites will be analyzed as continuous variables (log transformed and scaled to SD of 1), and regressions 
adjusted for age, sex, delirium assessment, CT-ICU length of stay, and surgical duration. To examine the unique 
predictive ability of these metabolites, we will conduct an exploratory stepwise logistic model including all 
metabolites meeting our threshold, and conduct cross-validation procedures to examine the internal consistency of 
these estimates. We will then construct a multimarker score based on the regression coefficients of the metabolites 
that were significant and consistent in our multivariable model, and then assess whether a model including clinical 
risk factors plus the multimarker panel improves delirium prediction compared with the model including clinical risk 
factors only.  
All EEG data will be downloaded for off-line computational analysis. Data will be visualized and analyzed using 
signal processing and statistical algorithms available in MatLab, and using algorithms developed in house by the study 
investigators. To address hypothesis 3·1, we will employ multitaper power spectral analysis,21 multitaper bivariate 
coherence analysis.18 We will also perform phase-amplitude modulation between low and high frequency EEG 
components.21 To address hypothesis 3·2, Segmentation of EEG recordings into burst and suppression periods will be 
performed in a semi-automated manner using an adaptation of previously described methods.22-24 We will quantify 
the depth of burst suppression using the burst suppression probability (BSP), a number between 0 and 1, which 
describes the instantaneous probability of the EEG being in a state of suppression. A BSP value of 0 corresponds to a 
continuously active EEG with no suppression, whereas a value of 1 corresponds to a completely isoelectric or 
suppressed EEG. 
5. POWER ANALYSIS 
The primary objective of this study is to detect a difference in the incidence of ICU delirium between the 
dexmedetomdine-induced sleep and normal care groups. Assuming a delirium event rate of 15%, a type I error of 
0·05, and power of 0·90, an n = 185 patients per group will enable us to detect an absolute difference 10% (i.e., 15% 
versus 5%). With respect to decreased morbidity and healthcare costs, this change represents a clinically meaningful 
difference. Therefore, we will recruit up to 370 patients total who receive the study intervention on postoperative day 
0. 
6. REMUNERATION 
Patients will not be compensated for this study. 
7. RISK AND DISCOMFORT 
Dexmedetomidine risks: The risks involved in the administration of dexmedetomidine include nausea, xerostomia, 
atrial fibrillation, and transient hypertension during drug loading. The significant risks involved are directly related to 
a drug induced reduction in sympathetic activity, resulting in hypotension and bradycardia. Rare case reports of sinus 
arrest in instances of rapid drug administration and in patients with a high resting vagal tone have also been described. 
Drug discontinuation, dose reduction, or the use of vasoactive substances causes a return of these hemodynamic 
parameters to baseline. All subject hemodynamic parameters will be continuously monitored to ensure that appropriate 
medical intervention will be instituted for any clinically significant hypotensive or bradycardic episodes. In addition, 
most of our study subjects will have temporary pacemakers in place for routine post surgical heart-rate management. 
Since dexmedetomidine maintains the respiratory rate and we are only administering a one-time dose (similar to our 
recently completed proof of concept study in healthy volunteers; NCT01485393), there is no concern for respiratory 
compromise.  
EEG risks: The risks associated with EEG electrodes are redness and irritation at placement site. 
Psychological risks: Psychological risks include the possibility of claustrophobia within the scanner.  
Questionnaire risks: Minimal risks associated with completing questionnaires are subject fatigue and the possibility 
of minor psychological distress associated with answering sensitive questions regarding psychological functioning. 
Data risks: Procedures are in place to reduce the likelihood of a breach of confidentiality including the de-
identification of data and storage of data only on partners approved devices/portals. However, there is a small risk that 
people outside of this study may be exposed to information about study subjects. 

Nighttime Dexmedetomidine for Delirium Prevention in Non-Mechanically Ventilated Patients after Cardiac 
Surgery: The MINDDS Randomized Controlled Trial (Qu et al.) 
 
 
 
 
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8. POTENTIAL BENEFITS 
Subjects will have no direct benefit from taking part in this study. Findings from these studies will help advance our 
understanding of the pathophysiology of delirium. In particular, this project will assess the role of sleep induction and 
neuroinflammation in the establishment and/or maintenance of delirium. As such, we envision that in the future the 
information obtained from the proposed research will enhance the diagnosis and management of delirium. 
9. MONITORING AND QUALITY ASSURANCE 
No identifiers other than study ID’s will be included in the dataset. Thus, all data will be deidentified and data will be 
stored on password protected partners computers and cluster for off-line analysis. The proposed study will be 
monitored for safety, with monthly staff meetings reviewing adverse events and treatment outcomes and directly 
reporting any adverse events. The PI will also routinely monitor and assure the validity and integrity of collected data 
and adherence to the IRB-approved protocol. The trained staff members who carry out the procedures will also 
carefully monitor the study throughout its duration. The team will evaluate the progress of the study, verify that the 
rights and well being of the subjects are protected, verify that the reported study data are accurate, complete and 
verifiable from source documents, and the conduct of the study is in compliance with the approved protocol and 
amendments. Outcome monitoring and adverse events will all be reported through appropriate channels of the Human 
Studies Committee. A DSMB will also oversee this study. 
Unanticipated problems involving risks to subjects or others including adverse events will be reported to the PHRC 
in accordance with PHRC unanticipated problems including adverse events reporting guidelines, as well as the RDRC 
within 5 days. 
 
10. SUPPLEMENTARY ANALYSIS  
In a supplementary analysis data from the MINDDS study will be combined with data and specimens from the 
Maximizing trEatment of Neurological Dysfunction using INtravenous Guanfacine (MENDING) study in an effort 
to help determine future routes of study of the alpha2 agonism on delirium and acquired-dementia/Alzheimer’s disease 
and related dementias (ADRD). This collaboration will be established between MGH and Vanderbilt University 
Medical Center in order to share data and specimens for analysis. 
Briefly, the MENDING trial leverages resources from three ongoing NIH-funded trials. Patients in the MENDING 
trial have been enrolled into one of the ongoing prospective studies through the Critical Illness, Brain Dysfunction, 
and Survivorship (CIBS) Center at Vanderbilt, all of which have daily delirium monitoring and 3- and 12-month 
cognitive assessments. These include the Illuminating Neuropsychological Dysfunction and Systemic Inflammatory 
Mechanisms Gleaned After Hospitalization in Trauma-ICU (INSIGHT-ICU) study (R01GM120484, PI: Patel), the 
Measuring Outcomes of Activity in Intensive Care (MOSAIC) study (K76AG054864, PI: Brummel); and the Bringing 
to light the Risk factors And Incidence of Neuropsychological dysfunction in ICU Survivors, 2nd (BRAIN-ICU-2) 
study (R01AG058639, PI: Ely). Patients enrolled into one of these parent observational studies will subsequently 
be consented for enrollment into the MENDING clinical trial, which evaluates the role of the alpha-2 agonist 
guanfacine. All study procedures for the MENDING trial at Vanderbilt are covered under their local IRB (Protocol 
202000). Additionally, the consent for all MENDING studies includes approval to share data and specimens to 
evaluate mechanisms and associations with delirium, consistent with the aims of the MINDDS study. Thus, sharing 
of specimens and data will be consistent with future use described in the informed consent. Data collected from the 
MENDING study will be used in conjunction with neurocognitive data from the MINDDS study in interpreting the 
potential of alpha-2 agonism on delirium and ADRD. 
All data shared between institutions will be coded so that the collaborating institution cannot identify individual 
participants. This limited dataset will only include dates (of neurocognitive assessments, admission/discharge) and 
ages over 89. All other identifiable aspects of data will be removed. No other identifiable information will be shared. 
If possible a completely deidentified data set will be shared between institutions. Data and specimen sharing will be 
bi-directional in order to study of the alpha2 agonism on delirium. Appropriate data and material transfer agreements 
will be obtained between sites prior to sharing of any data or specimens.  
 
 

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Surgery: The MINDDS Randomized Controlled Trial (Qu et al.) 
 
 
 
 
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