The Effects of Spasticity on Glucose Metabolism and Soft Tissue Body Composition in Individuals With Motor Complete and Motor Incomplete Spinal Cord Injury
Conditions: Spinal Cord Injuries
Sponsor: Fatih Sultan Mehmet Training and Research Hospital

Official Title: The effects of spasticity on glucose metabolism and soft tissue body composition in 
individuals with motor complete and motor incomplete spinal cord injury 
NCT03859960 
Document date: August 6th, 2020 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 
Study Protocol: 
Objective: Investigators aimed to assess the effects of spasticity on glucose metabolism and body 
composition in individuals with motor complete and incomplete SCI. 
Methods: This prospective, cross-sectional study was conducted at the inpatient rehabilitation unit 
of a training and research hospital from September 2014 to May 2018.  Participants with SCI were 
included to study if times from injury were at least one year. Participants had an AIS grades of A-D 
with spasticity. Spasticity was assessed with Penn Spasm Frequency Scale (PSFS) and Modified 
Ashworth Scale (MAS). Hip adductor and extensor spasticity, knee extensor and flexor spasticity and 
ankle plantar flexor spasticity were assessed by using MAS. Body composition was measured by dual-
energy x-ray absorptiometry. All participants underwent a 75 gram (g) oral glucose tolerance test 
(OGTT). Insulin sensitivity and insülin resistance were assessed by calculating Matsuda index and 
HOMA-IR. Investigators assessed the effects of spasticity on glucose metabolism and body 
composition in participants with SCI. 
Statistical analysis 
The IBM SPSS Statistics 22 (IBM SPSS, Turkey) program was used for the statistical analysis. Normal 
distribution was evaluated using the Shapiro-Wilk test. Descriptive statistics of mean, SD, and 
frequencies were calculated. Pearson correlation analysis was used to assess the association 
between the parameters with conformity to the normal distribution. Statistical significance was 
evaluated at p<0.05. 
Results: With regard to the ASIA impairment scale 14 patients were classified as grade A and B 
(motor complete injured) and the remaining 19 were classified as grade C and D (motor incomplete 
injured). There was a positive correlation between hip adductor spasticity and trunk, android and 
gynoid percent fat-free masses (FFM%), and between hip extensor spasticity and android FFM% in  

patients with motor complete SCI. There was a negative correlation between hip extensor and knee 
flexor spasticity and HOMA index; and positive correlation between hip adductor and extensor, knee 
flexor and extensor spasticity and Matsuda index in these patients. There was a positive correlation 
between knee extensor spasticity and gnyoid FFM% and also, between PSFS and arms, trunk, gynoid, 
and total FFM% in patients with motor incomplete SCI. There was a negative correlation between hip 
adductor and extensor spasticity, PSFS and level of fasting glucose in patients with motor incomplete 
SCI.