Question: who hit the first home run in the houston astrodome?
Answer: Mickey Mantle

On Opening Day , April 9 , 1965 , a sold - out crowd of 47,879 watched an exhibition game between the Houston Astros and the New York Yankees . President Lyndon B. Johnson and his wife Lady Bird were in attendance , as well as Texas Governor John Connally and Houston Mayor Louie Welch . Governor Connally tossed out the first ball for the first game ever played indoors . Dick '' Turk '' Farrell of the Astros threw the first pitch . Mickey Mantle had both the first hit ( a single ) and the first home run in the Astrodome . The Astros beat the Yankees that night , 2 - 1 .