Jerryhuang001/TF_network huggingface dataset:
Gene: VDR (ENSG00000111424)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Tim Hughes) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 comment: Motifs suggest facultative homodimeric binding
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene Candidate_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_Co-activation; DNA Binding_PMIDS:16750418;8674817
Annotated as a GO transcription factor: Yes
PDB structure: 1KB2
Gene: AATF (ENSG00000275700)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Likely does not bind to bind to DNA (PMID: 17634135).
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Binds TP53 to regulate its activity based on PMID: 25996291
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: PMID: 17634135  says it might not bind to bind to DNA 
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene Candidate__Transactivation_PMIDS:14627703
Annotated as a GO transcription factor: No
Gene: ABL1 (ENSG00000097007)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Does not meet any curation project inclusion criteria; should not have been included
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ABRA (ENSG00000174429)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: The Costars domain in this protein is an atypical winged helix protein that does not bind DNA but to other proteins (PMID: 21082705)
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Based on PMID: 21082705 the Costars domain in this protein is an atypical winged helix protein that does not bind DNA but to other proteins
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: AC020915.1 (ENSG00000142396)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ACOD1 (ENSG00000102794)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: ACTR3B (ENSG00000133627)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Tim Hughes) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: I don't see that any of the datasets includes this protein - why is it on our list?
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Does not meet any curation project inclusion criteria; should not have been included
Reviewer 2 notes: Does not meet any curation project inclusion criteria; should not have been included
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ACTR3C (ENSG00000106526)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Pfam match to an APSES domain - this is likely a false positive, as these domains are mostly present in bacteria and fungi
Committee notes: Domain match is not listed on other databases
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: CIS-BP Identifies an APES domain - this is likely a false positive Pfam match as these domains are mostly present in bacteria; and fungi
Reviewer 1 notes: False Positive Pfam Match
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ADAM8 (ENSG00000151651)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: ADAMTS17 (ENSG00000140470)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ADAMTS19 (ENSG00000145808)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Notes: Has a putative AT-hook
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ADAR (ENSG00000160710)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: PMID: 21728134 shows the ADAR protein bind to ds RNA and Z DNA.  At best it would  be a non-sequence specific DNA binding protein.  But, it has a well established role as a dsRNA binding protein, so it is unlikely to be a TF.
Committee notes: PMID: 21728134 says ADAR protein bind to ds RNA and Z DNA.  At best it would likely be a non-sequence specific DNA binding protein.  But, it has a well esblished role as a dsRNA binding protein.  I think it is unlikely to be a TF.
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 notes: should this be considered a TF? dsDNA binding could be off-target or antiviral defense
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: PMID: 21728134 says ADAR protein bind to ds RNA and Z DNA
Reviewer 2 notes: Needs a revisit
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
PDB structure: 1QBJ
Gene: ADGRA1 (ENSG00000197177)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ADGRG3 (ENSG00000182885)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: AEBP1 (ENSG00000106624)
DNA-binding domain: Unknown
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Comments: This is a protease, but its ability to bind DNA is supported by both gel-shift (PMID: 15654748) and ChIP (PMID: 22723309).
Committee notes: This is a protease, but its ability to bind DNA is supported by both gel-shift (e.g. PMID: 15654748) and ChIP (PMID: 22723309).  It is curious that only one lab has ever studied it - perhaps worth running on HT-SELEX and ChIP-seq.
Reviewer 1 (Matt Weirauch) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Use this reference instead: PMID 15654748 
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: PMID: 15654748 says AEBP1 has DNA mediated transcriptional repression activity.
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: AES (ENSG00000104964)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Likely a transcriptional co-factor
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Likely a transcriptional co-factor
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:10660609;11416139
Annotated as a GO transcription factor: No
Gene: AFAP1  (ENSG00000196526)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: There is no evidence suggesting DNA-binding activity
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: There is no evidence suggesting DNA-binding activity
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: AFF1 (ENSG00000172493)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Notes: Has a putative AT-hook
Comments: MLL fusion partner
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: Paper cited here claimed it's a putative TF
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: AFF3 (ENSG00000144218)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: (PMID: 8555498) only says that "In vitro-translated LAF-4 was able to bind strongly to double-stranded DNA cellulose" - that's more consistent with nonspecific DNA binding.  The key issue is whether the "Transcription factor AF4/FMR2 (IPR007797)" domain really is sequence specific.  Most of the work has been done on the one Drosophila ortholog, lilliuputian.  I see no evidence of DNA binding.  Recent work on this family in human indicate that it functions in coactivation (PMID: 27899651; PMID: 26171280)
Committee notes: PMID only says that "In vitro-translated LAF-4 was able to bind strongly to double-stranded DNA cellulose" - that's more consistent with nonspecific DNA binding.  The key issue is whether the "Transcription factor AF4/FMR2 (IPR007797)" domain really is sequence specific.  Most of the work has been done on the one Drosophila ortholog, lilliuputian.  I see no evidence of DNA binding.  Recent work on this family in human indicate that functions in coactivation (27899651; 26171280)
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: AF-4 Domain is annotated as a TF; however DNA-binding activity has not been shown (PMID:11171404)
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 
Reviewer 2 comment: PMID: 8555498 says alias LAF-4 binds ds DNA.
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: AFF4 (ENSG00000072364)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: (PMID: 8555498) only says that "In vitro-translated LAF-4 was able to bind strongly to double-stranded DNA cellulose" - that's more consistent with nonspecific DNA binding.  The key issue is whether the "Transcription factor AF4/FMR2 (IPR007797)" domain really is sequence specific.  Most of the work has been done on the one Drosophila ortholog, lilliuputian.  I see no evidence of DNA binding.  Recent work on this family in human indicate that it functions in coactivation (PMID: 27899651; PMID: 26171280)
Committee notes: PMID only says that "In vitro-translated LAF-4 was able to bind strongly to double-stranded DNA cellulose" - that's more consistent with nonspecific DNA binding.  The key issue is whether the "Transcription factor AF4/FMR2 (IPR007797)" domain really is sequence specific.  Most of the work has been done on the one Drosophila ortholog, lilliuputian.  I see no evidence of DNA binding.  Recent work on this family in human indicate that functions in coactivation (27899651; 26171280)
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: looks like a co-factor to me.
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: PMID: 10588740  says that the alias of AFF4; AF5q31; has transactivation domain and it has been reported to play critical role in fetal development.
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: AGER (ENSG00000204305)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: Contacts DNA in the structure (PDB: 4OI7)
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
TFclass considers it a TF: No
Gene: AGT (ENSG00000135744)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: AIM2 (ENSG00000163568)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: Based on (PDB: 3RN2), the protein binds DNA but contacts only the backbone; AIM2 binds cytrosolic dsDNA in the innate immune response
Committee notes: Based on PDB:3RN2 the protein binds DNA but contacts only the backbone; AIM2 binds cytrosolic dsDNA in innate immune response
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: Based on PDB:3RN2 the protein binds DNA but contacts only the backbone; AIM2 binds cytrosolic dsDNA in innate immune response
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
PDB structure: 3RN2
Gene: AKT1 (ENSG00000142208)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: ALK (ENSG00000171094)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Operates far upstream in the signaling cascade
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Operates far upstream in the signalling cascade
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: ALKBH2 (ENSG00000189046)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Binds DNA in the crystal structure (PDB: 3BTX)
TRH notes: alkB homolog 2, alpha-ketoglutarate dependent dioxygenase 
AJ notes: 3BTX
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation ;Binds DNA in the crystal structure; PDB: 3BTX
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
TFclass considers it a TF: No
Gene: AMH (ENSG00000104899)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: ANAPC2 (ENSG00000176248)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Scaffolding protein that associates with ubiquitin ligase complexes
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Scaffolding protein that associates with ubiquitin ligase complexes
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ANKRD30A (ENSG00000148513)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Notes: Has a putative AT-hook
Comments: GO citation (PMID: 11280766) has no evidence of DNA-binding activity and was based on homology 
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Only PMID: 11280766 claims that it is a putative TF and the evidence is weak
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: GO citation (PMID: 11280766) has no evidence of DNA-binding activity and was based on homology 
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: ANXA3 (ENSG00000138772)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Protein operates far upstream on the signaling cascade.
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Protein operates far upstream on the signaling cascade.
Reviewer 2 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes