Jerryhuang001/TF_network huggingface dataset:
Gene: TIGD6 (ENSG00000164296)
DNA-binding domain: CENPB
Is a transcription factor: Yes
TF assessment: Inferred motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Sam Lambert) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: While the DBD is likely sequence-specific there is no evidence for or against it's role in transcriptional regulation in the literature 
Reviewer 2 (Laura Campitelli) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: TIGD7 (ENSG00000140993)
DNA-binding domain: CENPB
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Reviewer 1 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Structurally related to CENPB
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: CAMTA1 (ENSG00000171735)
DNA-binding domain: CG-1
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Comments: Binds CGCATTGCG based on EMSA performed in (PMID: 25049392)
Reviewer 1 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Binds CGCATTGCG based on EMSA performed in PMID: 25049392
Reviewer 2 (Laura Campitelli) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: The CG-1 domain of CAMTA recognizes specific CGCG box-containing DNA sequences; and a nearby region activates the transcription. [PROSITE-ProRule:PRU00767]
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: CAMTA2 (ENSG00000108509)
DNA-binding domain: CG-1
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 notes: CG-1 domain
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:16678093
Annotated as a GO transcription factor: Yes
Gene: CARHSP1 (ENSG00000153048)
DNA-binding domain: CSD
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: RNA-binding protein (PMID: 11842224; PMID: 21078874)
Committee notes: Based on CSD Alignment
Reviewer 1 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Looks like an RBP: PMID 11842224
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Only positive evidence is the presence of a potential DBD (Cold-shock domain). However; CSDs have been shown to sometimes bind RNA. CARHSP1 was identified as a putative RNA-binding protein in a screen (PMID:21078874)
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: CSDC2 (ENSG00000172346)
DNA-binding domain: CSD
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: RNA-binding protein (PMID: 12801884)
Committee notes: Based on CSD Alignment
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: RBP?
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: PMID: 12801884  says it binds RNA
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: CSDE1 (ENSG00000009307)
DNA-binding domain: CSD
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Established RNA-binding protein.
Committee notes: Based on CSD Alignment
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Tim Hughes) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Known RNA binding protein
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: We got motifs in SELEX for two of CSD proteins; so might be this famiily protein could bind to DNA in a sequence-specifci manner
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: LIN28A (ENSG00000131914)
DNA-binding domain: CSD
Is a transcription factor: Yes
TF assessment: Inferred motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Comments: Might also bind RNA
Committee notes: Based on CSD Alignment
Reviewer 1 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: LIN28B (ENSG00000187772)
DNA-binding domain: CSD
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Comments: Structure (PDB: 4A75) is with single stranded DNA.
Committee notes: Based on CSD Alignment
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Structure PDB:4A75 is with single stranded DNA
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
PDB structure: 4A75
Gene: YBX1 (ENSG00000065978)
DNA-binding domain: CSD
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Comments: Might also bind RNA
Committee notes: Based on CSD Alignment
Reviewer 1 (Matt Weirauch) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_Single stranded RNA/DNA binding_TF PPI_PMIDS:15039105;15702969;1741293;15039105
Annotated as a GO transcription factor: Yes
Gene: YBX2 (ENSG00000006047)
DNA-binding domain: CSD
Is a transcription factor: Yes
TF assessment: Inferred motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Comments: Might also bind RNA
Committee notes: Based on CSD Alignment
Reviewer 1 (Laura Campitelli) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: YBX3 (ENSG00000060138)
DNA-binding domain: CSD
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: 100%ID - in vitro
Comments: Identical DBD to YBX1. Might also bind RNA.
Committee notes: Based on CSD Alignment
MTW notes: 100% DBDID to YBX1
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 2 Obligate heteromer
Reviewer 1 notes: should be retested
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: Not a TF - Evidence that it is not a TF___PMIDS:0
Annotated as a GO transcription factor: Yes
Gene: RBPJ (ENSG00000168214)
DNA-binding domain: CSL
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8152928;8625826
Annotated as a GO transcription factor: Yes
PDB structure: 2F8X
Gene: RBPJL (ENSG00000124232)
DNA-binding domain: CSL
Is a transcription factor: Yes
TF assessment: Inferred motif
Binding mode: 1 Monomer or homomultimer
Motif status: In vivo/Misc source
Reviewer 1 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: It is a TF based on similarity to RBPJ
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9111338;9111338;9111338;9111338;16354684
Annotated as a GO transcription factor: Yes
Gene: CUX1 (ENSG00000257923)
DNA-binding domain: CUT; Homeodomain
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:10864926;15994318
Annotated as a GO transcription factor: No
Gene: CUX2 (ENSG00000111249)
DNA-binding domain: CUT; Homeodomain
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Tim Hughes) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8798433;15656993
Annotated as a GO transcription factor: No
Gene: ONECUT1 (ENSG00000169856)
DNA-binding domain: CUT; Homeodomain
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15581617;16618419
Annotated as a GO transcription factor: Yes
PDB structure: 2D5V
Gene: ONECUT2 (ENSG00000119547)
DNA-binding domain: CUT; Homeodomain
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9915796
Annotated as a GO transcription factor: Yes
Gene: ONECUT3 (ENSG00000205922)
DNA-binding domain: CUT; Homeodomain
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene Candidate_DNA-Binding: sequence-specific; Transcription Regulatory Activity: heterochromatin interaction/binding_DNA Binding; Transactivation_PMIDS:11944891;11944891
Annotated as a GO transcription factor: Yes
Gene: SATB1 (ENSG00000182568)
DNA-binding domain: CUT; Homeodomain
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 3 Low specificity DNA-binding protein
Motif status: In vivo/Misc source
Notes: Only known motifs are from Transfac or HocoMoco - origin is uncertain
Comments: SATBs were analyzed by Gwenael Badis and Mike Berger a decade ago; by PBMs. It did not yield a "motif"; instead; the signal was very closely proportional to nucleotide content, as the name suggests (Special AT Binding).
Disagreement on assessment: Disagree
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 notes: Homeodomain; check for residues required for DNA binding
Reviewer 2 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: The PDB:2O49 has only the CUT-domain of the protein; but it is bound with decent dsDNA
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1505028;8114718;9340009
Annotated as a GO transcription factor: Yes
PDB structure: 2O49
Gene: SATB2 (ENSG00000119042)
DNA-binding domain: CUT; Homeodomain
Is a transcription factor: Yes
TF assessment: Inferred motif
Binding mode: 3 Low specificity DNA-binding protein
Motif status: In vivo/Misc source
Comments: SATBs were analyzed by Gwenael Badis and Mike Berger a decade ago; by PBMs. It did not yield a "motif"; instead; the signal was very closely proportional to nucleotide content, as the name suggests (Special AT Binding).
Reviewer 1 (Tim Hughes) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 comment: This protein was analyzed by Gwenael Badis and Mike Berger a decade ago; by PBMs.  It did not yield a "motif"; instead; the signal was very closely proportional to nucleotide content; as the name suggests (Special AT Binding).  This still makes it a 
Reviewer 2 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:14701874
Annotated as a GO transcription factor: No
Gene: CXXC1 (ENSG00000154832)
DNA-binding domain: CxxC
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Comments: X-ray structure (PDB:3QMI) indicates sequence specific binding through base contacts (PMID: 21407193).
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 comment: X-ray structure (PDB:3QMI) indicates sequence specific binding through base contacts (PMID:21407193). Source of Hocomoco motif is unclear. 
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
PDB structure: 3QMI
Gene: CXXC4 (ENSG00000168772)
DNA-binding domain: CxxC
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Comments: Binds unmethylated CpG-rich sequences: (PMID: 23563267). 
Disagreement on binding: Disagree
Reviewer 1 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Protein has a znf CXXC domain that is thought to associate with non-methylated CpG dinucleotides
Reviewer 2 (Matt Weirauch) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: Binds unmethylated CpG-rich sequences: PMID 23563267 
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: CXXC5 (ENSG00000171604)
DNA-binding domain: CxxC
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: DNMT1 (ENSG00000130816)
DNA-binding domain: CxxC
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 3 Low specificity DNA-binding protein
Reviewer 2 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
PDB structure: 4DA4
Gene: FBXL19 (ENSG00000099364)
DNA-binding domain: CxxC
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Reviewer 1 (Tim Hughes) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: I'm on the fence with this one.  It is included in CisBP because it has a CXXC domain.  It also has a PHD domain; which is sometimes found in chromatin-related proteins.  But; functional evidence to date seems to suggest other roles.
Reviewer 1 notes: Probably should discuss
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: KDM2A (ENSG00000173120)
DNA-binding domain: CxxC
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Comments: Has a CXXC zinc finger that recognizes CGs (PMID: 22083960)
Reviewer 1 (Matt Weirauch) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Has a CXXC zinc finger that recognizes CGs: PMID 22083960 
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: PMID: 22083960 says it take into account nonmethylated CG; methylated CG and presence of nucleosome for binding.
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: KDM2B (ENSG00000089094)
DNA-binding domain: CxxC
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: CXXC
Reviewer 2 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: TET1 (ENSG00000138336)
DNA-binding domain: CxxC
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 3 Low specificity DNA-binding protein
Reviewer 2 (Matt Weirauch) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: TET3 (ENSG00000187605)
DNA-binding domain: CxxC
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Reviewer 1 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
PDB structure: 4HP1
Gene: KMT2A (ENSG00000118058)
DNA-binding domain: CxxC; AT hook
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Comments: Contains 3 AT-hook domain, a CXXC domain, and a possible C2H2 domain.
TRH notes: Also has AT hooks
Reviewer 1 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Contain 3 AT-hook domain; a CXXC domain and a C2H2 domain
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 comment: PMID: 12453418
Reviewer 2 notes: AT hook protein type DNA binding; UniProtKB - Q03164
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12453418
Annotated as a GO transcription factor: Yes
Gene: KMT2B (ENSG00000272333)
DNA-binding domain: CxxC; AT hook
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Comments: Structural evidence shows direct DNA-binding (PDB:4PZI) and KMT2B appears to make specific contacts with methylated DNA.
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Structural evidence shows direct DNA-binding (PDB:4PZI) and KMT2B appears to make specific contacts with methylated DNA 
Reviewer 2 (Laura Campitelli) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: Histone methyltransferase 
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
PDB structure: 4PZI
Gene: DMRT1 (ENSG00000137090)
DNA-binding domain: DM
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0
Annotated as a GO transcription factor: Yes
PDB structure: 4YJ0
Gene: DMRT2 (ENSG00000173253)
DNA-binding domain: DM
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0
Annotated as a GO transcription factor: Yes