Jerryhuang001/TF_network huggingface dataset:
Gene: SOX6 (ENSG00000110693)
DNA-binding domain: HMG/Sox
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Committee notes: Based on HMG/Sox alignment
AJ notes: "Has known motif", "1 Monomer or homomultimer". Aminoacid is very similar to the other SOX-subgroup of the HMG proteins. Mouse PBM motif is ok
Reviewer 1 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 comment: monomer and also forms hetero dimer with TBX21. Logo from jolma2015 not visible.
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7567444;11504872
Annotated as a GO transcription factor: Yes
Gene: SOX7 (ENSG00000171056)
DNA-binding domain: HMG/Sox
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Committee notes: Based on HMG/Sox alignment
AJ notes: "Has known motif", "1 Monomer or homomultimer". Aminoacid is very similar to the other SOX-subgroup of the HMG proteins. HT-SELEX motif is for hairpin DNA. Mouse PBM motif is ok
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15220343
Annotated as a GO transcription factor: Yes
Gene: SOX8 (ENSG00000005513)
DNA-binding domain: HMG/Sox
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Committee notes: Based on HMG/Sox alignment
AJ notes: "Has known motif", "1 Monomer or homomultimer". Aminoacid is very similar to the other SOX-subgroup of the HMG proteins. HT-SELEX motif from Yin et al 2017 is ok
Reviewer 1 (Tim Hughes) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; TF PPI_PMIDS:12732652
Annotated as a GO transcription factor: No
Gene: SOX9 (ENSG00000125398)
DNA-binding domain: HMG/Sox
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Comments: Also binds ssDNA loops.
Committee notes: Based on HMG/Sox alignment
AJ notes: "Has known motif", "1 Monomer or homomultimer". Aminoacid is very similar to the other SOX-subgroup of the HMG proteins. Jaspar motif is ok
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 comment: binds also ssDNA loops
Reviewer 2 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15590666
Annotated as a GO transcription factor: Yes
PDB structure: 4EUW
Gene: SRY (ENSG00000184895)
DNA-binding domain: HMG/Sox
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Committee notes: Based on HMG/Sox alignment
AJ notes: "Has known motif", "1 Monomer or homomultimer". Aminoacid is very similar to the other SOX-subgroup of the HMG proteins. HT-SELEX motif is for hairpin DNA. Mouse PBM motif is ok
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Jolma 2013 models are derived from binding to single stranded DNA derived aptamer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene Candidate__DNA Binding_PMIDS:7813448;8190643
Annotated as a GO transcription factor: Yes
PDB structure: 1HRY
Gene: SSRP1 (ENSG00000149136)
DNA-binding domain: HMG/Sox
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: HMG domain is highly divergent based on AA-sequence
Committee notes: Based on HMG/Sox alignment
AJ notes: "Unlikely to be sequence specific TF","3 Low specificity DNA-binding protein"HMG domain is highly divergent based on AA-sequence
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 notes: check amino-acids required for binding
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: HMG related protein
Reviewer 2 notes: needs revisit
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:10336466
Annotated as a GO transcription factor: No
Gene: TCF7 (ENSG00000081059)
DNA-binding domain: HMG/Sox
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Committee notes: Based on HMG/Sox alignment
AJ notes: "Has known motif", "1 Monomer or homomultimer" Very well established classical TF that also has HT-SELEX motifs
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7579399
Annotated as a GO transcription factor: No
Gene: TCF7L1 (ENSG00000152284)
DNA-binding domain: HMG/Sox
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Committee notes: Based on HMG/Sox alignment
AJ notes: "Has known motif", "1 Monomer or homomultimer" Very well established classical TF that also has HT-SELEX motifs
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:2493990;14627819
Annotated as a GO transcription factor: Yes
Gene: TCF7L2 (ENSG00000148737)
DNA-binding domain: HMG/Sox
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: 100%ID - in vitro
Committee notes: Based on HMG/Sox alignment
AJ notes: "Has known motif", "1 Monomer or homomultimer" Aminoacid sequence is very similar to other classical TCF-LEF subgroup of HMG proteins. All direct motifs seem like they are derived from ChIP-seq, but they are very similar to in vitro motifs for close paralogs
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Transfac motif looks like expected Sox family motif 
Reviewer 2 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene Candidate__Other_PMIDS:12861022;15576399;9727977;15060161;15576399
Annotated as a GO transcription factor: Yes
Gene: TFAM (ENSG00000108064)
DNA-binding domain: HMG/Sox
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: HMG domain is highly divergent based on AA-sequence
Committee notes: Based on HMG/Sox alignment
AJ notes: "Unlikely to be sequence specific TF","3 Low specificity DNA-binding protein"HMG domain is highly divergent based on AA-sequence
Reviewer 1 (Tim Hughes) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:2035027
Annotated as a GO transcription factor: Yes
PDB structure: 3TMM
Gene: TOX (ENSG00000198846)
DNA-binding domain: HMG/Sox
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: Predicted to be a non- or low specificity TF (PMID: 12697058). However, there is a DAM-id based motif with SSSSGNNGCG-consensus (PMID: 25527292), but this does not look like HMG-site
Committee notes: Based on HMG/Sox alignment
MTW notes: Predicted to be a non- or low specificity TF PMID 12697058
AJ notes: TOX-proteins are clearly their own subgroup among HMG-proteins
Disagreement on binding: Disagree
Reviewer 1 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Predicted to be a non- or low specificity TF PMID 12697058; although there is a DAM-id based motif with SSSSGNNGCG-consensus published in PMID: 25527292 which however does not look like HMG-site
Reviewer 2 (Sam Lambert) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: No evidence for or against DNA-binding is present in the literature 
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: Indeterminate - There is no evidence for or against this genes role as a TF__Other_PMIDS:11850626;15078895
Annotated as a GO transcription factor: No
Gene: TOX2 (ENSG00000124191)
DNA-binding domain: HMG/Sox
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: TOX proteins are clearly their own distinct subfamily of HMG proteins.  No strong evidence for them binding DNA specifically.
Committee notes: Based on HMG/Sox alignment
AJ notes: TOX-proteins are clearly their own subgroup among HMG-proteins
Reviewer 1 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 notes: HMGs needs to be re categorize.
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: TOX3 (ENSG00000103460)
DNA-binding domain: HMG/Sox
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: TOX proteins are clearly their own distinct subfamily of HMG proteins.  No strong evidence for them binding DNA specifically.
Committee notes: Based on HMG/Sox alignment
AJ notes: TOX-proteins are clearly their own subgroup among HMG-proteins that are almost identical to each other. Taipale lab has unpublished models for TOX3 and TOX4
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: Based on PMID: 27080130 it drives expression from Nestlin promoter. PMID: 25527292 has a Dam-id seq. motif for a paralog Tox with consensus SSSSGNNGCG
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: TOX4 (ENSG00000092203)
DNA-binding domain: HMG/Sox
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: TOX proteins are clearly their own distinct subfamily of HMG proteins.  No strong evidence for them binding DNA specifically.
Committee notes: Based on HMG/Sox alignment
AJ notes: TOX-proteins are clearly their own subgroup among HMG-proteins that are almost identical to each other. Taipale lab has unpublished models for TOX3 and TOX4
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Tim Hughes) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Supported only by unpublished Taipale lab data.  Otherwise it's more similar to HMGB than SOX proteins.  TOX forms its own class; however.
Reviewer 1 notes: It would be helpful to see the Taipale lab motif
Reviewer 2 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: UBTF (ENSG00000108312)
DNA-binding domain: HMG/Sox
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: No evidence for or against specific DNA-binding by this class of HMG box containing proteins
Committee notes: Based on HMG/Sox alignment
AJ notes: Divergent HMG motif, doesn't cluster either with specific or nonspecific HMG proteins
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Looks like a non-specific HMG box to me
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: UBTFL1 (ENSG00000255009)
DNA-binding domain: HMG/Sox
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: No evidence for or against specific DNA-binding by this class of HMG box containing proteins
Committee notes: Based on HMG/Sox alignment
AJ notes: Divergent HMG motif, doesn't cluster either with specific or nonspecific HMG proteins
Reviewer 1 (Sam Lambert) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: No evidence for or against specific DNA-binding by this class of HMG box containing proteins
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: WDHD1 (ENSG00000198554)
DNA-binding domain: HMG/Sox
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: Divergent HMG motif, doesn't cluster either with specific or nonspecific HMG proteins
Committee notes: Based on HMG/Sox alignment
AJ notes: Divergent HMG motif, doesn't cluster either with specific or nonspecific HMG proteins
Reviewer 1 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 notes: needs revisit
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: BHMG1 (ENSG00000237452)
DNA-binding domain: HMG/Sox; bHLH
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Based on the alignment, it lacks a proper HMG domain. bHLH domain is also highly unlike any other human bHLH TF (<40% DBD ID)
MTW notes: Based on the HMG alignments, this is a MAJOR outlier and I don?t think it could possibly really be an HMG
TRH notes: Entrez description is "basic helix-loop-helix and HMG-box containing 1"
AJ notes: Based on alignment It really does not have a proper HMG domain
Reviewer 1 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 notes: bHLH and HMG; check for residues required for DNA binding
Reviewer 2 (Laura Campitelli) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: #N/A
TFclass considers it a TF: #N/A
TF-CAT classification: #N/A
Annotated as a GO transcription factor: #N/A
PDB structure: #N/A
Gene: ADNP (ENSG00000101126)
DNA-binding domain: Homeodomain
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Reviewer 1 (Matt Weirauch) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ADNP2 (ENSG00000101544)
DNA-binding domain: Homeodomain
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Reviewer 1 (Matt Weirauch) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ALX1 (ENSG00000180318)
DNA-binding domain: Homeodomain
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9753625;12390248;8756334;9847249;12390248
Annotated as a GO transcription factor: Yes
Gene: ALX3 (ENSG00000156150)
DNA-binding domain: Homeodomain
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ALX4 (ENSG00000052850)
DNA-binding domain: Homeodomain
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ANHX (ENSG00000227059)
DNA-binding domain: Homeodomain
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ARGFX (ENSG00000186103)
DNA-binding domain: Homeodomain
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ARX (ENSG00000004848)
DNA-binding domain: Homeodomain
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Matt Weirauch) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15930104
Annotated as a GO transcription factor: Yes
Gene: BARHL1 (ENSG00000125492)
DNA-binding domain: Homeodomain
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Transactivation_PMIDS:16226339
Annotated as a GO transcription factor: Yes
Gene: BARHL2 (ENSG00000143032)
DNA-binding domain: Homeodomain
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: BARX1 (ENSG00000131668)
DNA-binding domain: Homeodomain
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Notes: Has a putative AT-hook
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene Candidate__Transactivation_PMIDS:15809042;7669690;15809042
Annotated as a GO transcription factor: Yes
Gene: BARX2 (ENSG00000043039)
DNA-binding domain: Homeodomain
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Notes: Has a putative AT-hook
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Matt Weirauch) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:14744868;15728386
Annotated as a GO transcription factor: Yes
Gene: BSX (ENSG00000188909)
DNA-binding domain: Homeodomain
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes