Jerryhuang001/TF_network huggingface dataset:
Gene: ETV5 (ENSG00000244405)
DNA-binding domain: Ets
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:15138262;15466854;15857832
Annotated as a GO transcription factor: Yes
PDB structure: 4UNO
Gene: ETV6 (ENSG00000139083)
DNA-binding domain: Ets
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Matt Weirauch) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
PDB structure: 4MHG
Gene: ETV7 (ENSG00000010030)
DNA-binding domain: Ets
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Comments: Experimental low-throughput evidence of DNA-binding and changes in reporter expression (PMID: 11108721)
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 comment: Experimental low-throughput evidence of DNA-binding and changes in reporter expression (PMID:11108721)
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: FEV (ENSG00000163497)
DNA-binding domain: Ets
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9468386
Annotated as a GO transcription factor: Yes
PDB structure: 3ZP5
Gene: FLI1 (ENSG00000151702)
DNA-binding domain: Ets
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:1445800;1522903;8449942;8502483;12065417;14570912
Annotated as a GO transcription factor: Yes
PDB structure: 5E8I
Gene: GABPA (ENSG00000154727)
DNA-binding domain: Ets
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10773883;15361867
Annotated as a GO transcription factor: Yes
PDB structure: 1AWC
Gene: SPDEF (ENSG00000124664)
DNA-binding domain: Ets
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_DNA Binding; Transactivation_PMIDS:10625666
Annotated as a GO transcription factor: Yes
PDB structure: 1YO5
Gene: SPI1 (ENSG00000066336)
DNA-binding domain: Ets
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Matt Weirauch) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9211934;10523830;7624145
Annotated as a GO transcription factor: Yes
PDB structure: 1PUE
Gene: SPIB (ENSG00000269404)
DNA-binding domain: Ets
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1406622
Annotated as a GO transcription factor: Yes
Gene: SPIC (ENSG00000166211)
DNA-binding domain: Ets
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12749910
Annotated as a GO transcription factor: Yes
Gene: ELF3 (ENSG00000163435)
DNA-binding domain: Ets; AT hook
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:11893733
Annotated as a GO transcription factor: Yes
PDB structure: 3JTG
Gene: FLYWCH1 (ENSG00000059122)
DNA-binding domain: FLYWCH
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Comments: Several C. elegans FLYWCH domain proteins bind specific DNA sequences in Y1H and EMSA (PMID: 18794349 and PMID: 15165844).
TRH notes: New DBD family in C. elegans - we are assuming it is also a DBD in human
Reviewer 1 (Tim Hughes) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Several C. elegans FLYWCH domain proteins bind specific DNA sequences in Y1H and EMSA (PMID:18794349 and PMID:15165844) - no human yet it seems; however.
Reviewer 2 (Matt Weirauch) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: There is evidence that a C. elegans FLYWICH TF binds DNA; but not much is known about mammalian FLYWICHs
Reviewer 2 notes: Yes - this is a new DBD family we have added to CisBP and not much is known about it.
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: FOXA1 (ENSG00000129514)
DNA-binding domain: Forkhead
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:2227418;11864602;15485926;15539431
Annotated as a GO transcription factor: Yes
Gene: FOXA2 (ENSG00000125798)
DNA-binding domain: Forkhead
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Matt Weirauch) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:16847327
Annotated as a GO transcription factor: Yes
Gene: FOXA3 (ENSG00000170608)
DNA-binding domain: Forkhead
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
PDB structure: 1VTN
Gene: FOXB1 (ENSG00000171956)
DNA-binding domain: Forkhead
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Matt Weirauch) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0
Annotated as a GO transcription factor: Yes
Gene: FOXB2 (ENSG00000204612)
DNA-binding domain: Forkhead
Is a transcription factor: Yes
TF assessment: Inferred motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Disagreement on assessment: Disagree
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: FOXC1 (ENSG00000054598)
DNA-binding domain: Forkhead
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Matt Weirauch) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11179011;17000708;12533514;15684392
Annotated as a GO transcription factor: Yes
Gene: FOXC2 (ENSG00000176692)
DNA-binding domain: Forkhead
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: FOXD1 (ENSG00000251493)
DNA-binding domain: Forkhead
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: 100%ID - in vitro
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7957066;13678594
Annotated as a GO transcription factor: Yes
Gene: FOXD2 (ENSG00000186564)
DNA-binding domain: Forkhead
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene Candidate_DNA-Binding: sequence-specific_Transactivation_PMIDS:12621056
Annotated as a GO transcription factor: Yes
Gene: FOXD3 (ENSG00000187140)
DNA-binding domain: Forkhead
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8139574
Annotated as a GO transcription factor: Yes
PDB structure: 2HDC
Gene: FOXD4 (ENSG00000170122)
DNA-binding domain: Forkhead
Is a transcription factor: Yes
TF assessment: Inferred motif
Binding mode: 1 Monomer or homomultimer
Motif status: In vivo/Misc source
Disagreement on assessment: Disagree
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Transfac motif is likely a homodimer and inferred from a protein with 96% DBD identity 
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: FOXD4L1 (ENSG00000184492)
DNA-binding domain: Forkhead
Is a transcription factor: Yes
TF assessment: Inferred motif
Binding mode: 1 Monomer or homomultimer
Motif status: In vivo/Misc source
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Motif is suspicious as it doesn't seem like a target site at least for a monomeric forkhead protein
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 comment: Transfac motif appears to be dimeric  
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: FOXD4L2 (ENSG00000204828)
DNA-binding domain: Forkhead
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Notes: Only known motifs are from Transfac or HocoMoco - origin is uncertain
Comments: This ENSEMBL ID has been retired.
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Ensemble id. Has been deprecated, gene is apparently same as FOXD4L4
Reviewer 1 notes: Transfac_Transfac_Matys_Direct
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: This ENSEMBL ID has been retired. Transfac motif is likely linked to FOXD4L (FOXD4L4) which is an active gene
TFclass considers it a TF: No
Gene: FOXD4L3 (ENSG00000187559)
DNA-binding domain: Forkhead
Is a transcription factor: Yes
TF assessment: Inferred motif
Binding mode: 1 Monomer or homomultimer
Motif status: In vivo/Misc source
Disagreement on assessment: Disagree
Reviewer 1 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 notes: check amino-acids required for binding
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 comment: Inferred Transfac appears to be dimeric and possibly overlapping - has weak similarity to a Forkhead monomeric site
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: FOXD4L4 (ENSG00000184659)
DNA-binding domain: Forkhead
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: In vivo/Misc source
Notes: Only known motifs are from Transfac or HocoMoco - origin is uncertain
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Hard to tell if the Transfac motif is overlapping motifs; has some similarity to the Forkhead monomeric binding site 
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: FOXD4L5 (ENSG00000204779)
DNA-binding domain: Forkhead
Is a transcription factor: Yes
TF assessment: Inferred motif
Binding mode: 1 Monomer or homomultimer
Motif status: In vivo/Misc source
Reviewer 1 (Laura Campitelli) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7957066;15302827
Annotated as a GO transcription factor: Yes
Gene: FOXD4L6 (ENSG00000273514)
DNA-binding domain: Forkhead
Is a transcription factor: Yes
TF assessment: Inferred motif
Binding mode: 1 Monomer or homomultimer
Motif status: In vivo/Misc source
Disagreement on assessment: Disagree
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Motif is suspicious; it does not look like a FOX-protein but as some kind of promoter signal. FOXD4 has only one copy of paralogs in mouse but seven in human PMID: 20650821 
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: FOXE1 (ENSG00000178919)
DNA-binding domain: Forkhead
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: Indeterminate - There is no evidence for or against this genes role as a TF__TF PPI_PMIDS:15367491;15223130
Annotated as a GO transcription factor: Yes
Gene: FOXE3 (ENSG00000186790)
DNA-binding domain: Forkhead
Is a transcription factor: Yes
TF assessment: Inferred motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Laura Campitelli) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0
Annotated as a GO transcription factor: Yes
Gene: FOXF1 (ENSG00000103241)
DNA-binding domain: Forkhead
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: In vivo/Misc source
Notes: Only known motifs are from Transfac or HocoMoco - origin is uncertain
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Lower confidence PWMs are classical forkhead target-sites
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8626802
Annotated as a GO transcription factor: Yes
Gene: FOXF2 (ENSG00000137273)
DNA-binding domain: Forkhead
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: In vivo/Misc source
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 comment: The motifs are classical fox-target sites; there is also a unpublished Taipale lab motif.
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8626802
Annotated as a GO transcription factor: Yes
Gene: FOXG1 (ENSG00000176165)
DNA-binding domain: Forkhead
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7585630;16314515;17482455
Annotated as a GO transcription factor: Yes
Gene: FOXH1 (ENSG00000160973)
DNA-binding domain: Forkhead
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: In vivo/Misc source
Comments: Full length protein did not yield an HT-SELEX motif
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 2 Obligate heteromer
Reviewer 1 notes: odd motif; could be indirect or heterodimer
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 
Reviewer 2 comment: the full length has been tested in SELEX
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_Co-activation; DNA Binding; TF PPI_PMIDS:9702197;9858566
Annotated as a GO transcription factor: Yes
Gene: FOXI1 (ENSG00000168269)
DNA-binding domain: Forkhead
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9153225
Annotated as a GO transcription factor: Yes
Gene: FOXI2 (ENSG00000186766)
DNA-binding domain: Forkhead
Is a transcription factor: Yes
TF assessment: Inferred motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 notes: check amino-acids required for binding
Reviewer 2 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: Likely to be a TF due to evidence of binding specificity of close orthologs
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes