Jerryhuang001/TF_network huggingface dataset:
Gene: PHF20 (ENSG00000025293)
DNA-binding domain: AT hook
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
MTW notes: HAT complex member (PMID 27760318). Does contain possible AT-hook
Disagreement on assessment: Disagree
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Protein is a component of histone acetyl-transferase complex that recognises H3K4me2 to add H4K16ac modification PMID:27760318. Has potential AT-hook KRKR-GRP-PSIA
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: The protein contains a AT-hook domain.
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: PHF21A (ENSG00000135365)
DNA-binding domain: AT hook
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Notes: Has a putative AT-hook
MTW notes: SMART has a single AT hook; PMID 11207365 shows it binds DNA non-specifically, supposedly through an HMG box
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 notes: AT-hook; check
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 comment: It is noted above that it has high confidence PWM. 
Reviewer 2 notes: will be considered later.
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0
Annotated as a GO transcription factor: No
Gene: PRR12 (ENSG00000126464)
DNA-binding domain: AT hook
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Tim Hughes) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: It does have two AT hooks on SMART
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: SCML4 (ENSG00000146285)
DNA-binding domain: AT hook
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Reviewer 1 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Putative polycomb protein by similarity (UniProt Q8N228)
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: SETBP1 (ENSG00000152217)
DNA-binding domain: AT hook
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Comments: Orthologous protein from mouse (Setbp1) bind DNA sequence-specifically by PBM  
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Orthologous protein from mouse (Setbp1) bind DNA sequence-specifically by PBM  
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 comment: AT hook containing protein UniProtKB - Q9Y6X0
Reviewer 2 notes: needs revisit
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: SRCAP (ENSG00000080603)
DNA-binding domain: AT hook
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Disagreement on binding: Disagree
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Helicase protein that loads H2A.Z into nucleosomes
Reviewer 2 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: C11orf95 (ENSG00000188070)
DNA-binding domain: BED ZF
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Committee notes: Based on BED ZF Alignment
Disagreement on assessment: Disagree
Reviewer 1 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 notes: BED domain only; check domain calls and residues required for DNA binding
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: FAM200B (ENSG00000237765)
DNA-binding domain: BED ZF
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Committee notes: Based on BED ZF Alignment
Reviewer 1 (Laura Campitelli) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: SGSM2 (ENSG00000141258)
DNA-binding domain: BED ZF
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Committee notes: Based on BED ZF Alignment
Reviewer 1 (Matt Weirauch) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Need to decide what to do with BED zinc fingers - there are about 12 of them; and only ZBED1 has a motif (from SELEX).
Reviewer 1 notes: Yes - BED ZFs need to be discussed I think
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ZBED1 (ENSG00000214717)
DNA-binding domain: BED ZF
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Committee notes: Based on BED ZF Alignment
AJ notes: "Has known motif","1 Monomer or homomultimer" has many independent HT-SELEX models from Jolma 2013 and Yin 2017
Reviewer 1 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: ZBED2 (ENSG00000177494)
DNA-binding domain: BED ZF
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Comments: Has a BED domain that should bind DNA, but lacks the dimerization domain (PMID: 20016685).
Committee notes: Based on BED ZF Alignment
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 notes: BED domain only; check domain calls and residues required for DNA binding
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: PMID: 20016685 says it has BED domain which should bind DNA but lacks the dimerization domain
Reviewer 2 notes: May need a revisit
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ZBED3 (ENSG00000132846)
DNA-binding domain: BED ZF
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Committee notes: Based on BED ZF Alignment
Reviewer 1 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 notes: BED Zf; need to check amino-acids required for DNA binding
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ZBED4 (ENSG00000100426)
DNA-binding domain: BED ZF
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Committee notes: Based on BED ZF Alignment
Disagreement on assessment: Disagree
Reviewer 1 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 notes: BED Zf; need to check amino-acids required for DNA binding
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: ZBED5 (ENSG00000236287)
DNA-binding domain: BED ZF
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Committee notes: Based on BED ZF Alignment
Reviewer 1 (Laura Campitelli) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: ZBED6 (ENSG00000257315)
DNA-binding domain: BED ZF
Is a transcription factor: Yes
TF assessment: Inferred motif
Binding mode: 1 Monomer or homomultimer
Motif status: In vivo/Misc source
Committee notes: Based on BED ZF Alignment
TRH notes: PMID: 20016685
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 comment: ChIP-seq motif in Transfac is probably from this study PMID: 20016685 
Reviewer 2 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: ZBED8 (ENSG00000221886)
DNA-binding domain: BED ZF
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Despite its name, does not have a detectable BED ZF domain.
MTW notes: Despite its name, does not have a detectable BED ZF domain
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 notes: BED domain in name but domain not called; check domain calls and residues required for DNA binding
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: ZBED9 (ENSG00000232040)
DNA-binding domain: BED ZF
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Committee notes: Based on BED ZF Alignment
Reviewer 1 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: C2H2 SCAN domain
Reviewer 2 notes: needs revisit
TFclass considers it a TF: No
Gene: AHR (ENSG00000106546)
DNA-binding domain: bHLH
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: In vivo/Misc source
Notes: Only known motifs are from Transfac or HocoMoco - origin is uncertain
Reviewer 1 (Tim Hughes) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 comment: PMIDS:7592839 claims it binds E-box as a homodimer in vitro; so I put homodimer above.
Reviewer 2 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 comment: Can also bind as a heterodimer with ARNT [PMID:12213385]
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7592839
Annotated as a GO transcription factor: Yes
Gene: AHRR (ENSG00000063438)
DNA-binding domain: bHLH
Is a transcription factor: Yes
TF assessment: Inferred motif
Binding mode: 1 Monomer or homomultimer
Motif status: In vivo/Misc source
AJ notes: "1 Monomer or homomultimer" HNGC symbol is AHRR and it is very similar to AHR and should be called accordingly. Based on PMIDS:7592839 AHR can bind as a homodimer. Probably protein however strongly prefers forming heterodimers
Disagreement on binding: Disagree
Reviewer 1 (Tim Hughes) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Motifs for several orthologs on CisBP.  Associated with DNA by ChIP (PMID:17890447)
Reviewer 2 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 2 Obligate heteromer
Reviewer 2 comment: Based on PMID:17949687 it binds DNA as a heterodimer with ARNT; HNGC-symbol is AHRR
Reviewer 2 notes: HNGC-symbol is AHRR
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ARNT (ENSG00000143437)
DNA-binding domain: bHLH
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: 100%ID - in vitro
AJ notes: Based on PMID: 7892203 it can bind also as a homodimer. The crystal structure has HIF1A - ARNT heterodimer
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 2 Obligate heteromer
Reviewer 1 notes: most likely obligate heterodimer
Reviewer 2 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7592839
Annotated as a GO transcription factor: Yes
PDB structure: 4ZPR
Gene: ARNT2 (ENSG00000172379)
DNA-binding domain: bHLH
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Matt Weirauch) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8657146
Annotated as a GO transcription factor: Yes
Gene: ARNTL (ENSG00000133794)
DNA-binding domain: bHLH
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; TF PPI_PMIDS:9576906;9616112
Annotated as a GO transcription factor: Yes
PDB structure: 4H10
Gene: ARNTL2 (ENSG00000029153)
DNA-binding domain: bHLH
Is a transcription factor: Yes
TF assessment: Inferred motif
Binding mode: 2 Obligate heteromer
Motif status: High-throughput in vitro
Comments: ARNTL2 Forms heterodimers with CLOCK and NPAS2 (PMID:10864977 ).
Reviewer 1 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 2 Obligate heteromer
Reviewer 1 notes: clone wrong or obligate heterodimer; check also residues
Reviewer 2 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 2 Obligate heteromer
Reviewer 2 comment: PMID:10864977 ARNTL2 Forms heterodimers with CLOCK and NPAS2
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: ASCL1 (ENSG00000139352)
DNA-binding domain: bHLH
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding; TF PPI; Transactivation_PMIDS:8662987;8900141
Annotated as a GO transcription factor: Yes
Gene: ASCL2 (ENSG00000183734)
DNA-binding domain: bHLH
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: ASCL3 (ENSG00000176009)
DNA-binding domain: bHLH
Is a transcription factor: Yes
TF assessment: Inferred motif
Binding mode: 2 Obligate heteromer
Motif status: High-throughput in vitro
Comments: ASCL1 heterodimerizes with TCF3; TCF4 and TCF12 (PMID: 24835951).
Reviewer 1 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 2 Obligate heteromer
Reviewer 1 comment: ASCL1 heterodimerizes with TCF3; TCF4 and TCF12 PMID: 24835951
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 2 Obligate heteromer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ASCL4 (ENSG00000187855)
DNA-binding domain: bHLH
Is a transcription factor: Yes
TF assessment: Inferred motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Comments: Probably heterodimerizes with TCF3; TCF4 or TCF12 like the other ASCL TFs
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 2 Obligate heteromer
Reviewer 1 comment: Probably heterodimerizes with TCF3; TCF4 or TCF12 like the other ASCL TFs
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 comment: Indirect motif has 50% DBD Identity with human/mouse ASCL1. Weak in vitro motifs could be because it prefers to bind as heterodimer with bHLH TCF proteins 
Reviewer 2 notes: Missing motif logos/info 
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ASCL5 (ENSG00000232237)
DNA-binding domain: bHLH
Is a transcription factor: Yes
TF assessment: Inferred motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Comments: Probably heterodimerizes with TCF3; TCF4 or TCF12 like the other ASCL TFs
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 2 Obligate heteromer
Reviewer 1 notes: could need processing or be an obligate heteromer; check amino-acids required for DNA binding
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: ATOH1 (ENSG00000172238)
DNA-binding domain: bHLH
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Matt Weirauch) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_Co-activation_PMIDS:14757642
Annotated as a GO transcription factor: Yes
Gene: ATOH7 (ENSG00000179774)
DNA-binding domain: bHLH
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene Candidate__Transactivation_PMIDS:7721778;15882586;17653051
Annotated as a GO transcription factor: No
Gene: ATOH8 (ENSG00000168874)
DNA-binding domain: bHLH
Is a transcription factor: Yes
TF assessment: Inferred motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
TRH notes: Not clear what is the source of the known motif.
AJ notes: "Likely to be a sequence specific TF" No, we do not have unpublished data for this. Based on aminoacid sequence the protein seems like a proper bHLH similar to TCF3, TCF4 and TCF12
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 notes: check amino-acids required for binding
Reviewer 2 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene Candidate_DNA-Binding: sequence-specific_Other_PMIDS:11733035;12419857
Annotated as a GO transcription factor: Yes
Gene: BHLHA15 (ENSG00000180535)
DNA-binding domain: bHLH
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: BHLHA9 (ENSG00000205899)
DNA-binding domain: bHLH
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 2 Obligate heteromer
Motif status: No motif
Comments: Protein heterodimerizes with TCF3; TCF4 and TCF12 (PMID: 25466284).
Reviewer 1 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 2 Obligate heteromer
Reviewer 1 comment: Protein heterodimerizes with TCF3; TCF4 and TCF12 and mutations in its DBD causes syndactyly PMID: 25466284
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 2 Obligate heteromer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: BHLHE22 (ENSG00000180828)
DNA-binding domain: bHLH
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes