Jerryhuang001/TF_network huggingface dataset:
Gene: MIER3 (ENSG00000155545)
DNA-binding domain: Myb/SANT
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: MIER3's Myb domain is more similar to the non-DNA-binding SANT domain. Tested on both PBM and HT-SELEX, with no motif.
SL notes: MIER3's Myb domain is more similar to the non-DNA-binding SANT domain 
Disagreement on binding: Disagree
Reviewer 1 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: chromatin binder.  tested on both PBM and HT-SELEX; with no motif
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: MIS18BP1 (ENSG00000129534)
DNA-binding domain: Myb/SANT
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Contains 1 SANT domain, and a SANTA domain 
SL notes: Contains 1 SANT domain, and a SANTA domain 
Reviewer 1 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Involved in chromosome segregation [PMID: 17339379]
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: MSANTD4 (ENSG00000170903)
DNA-binding domain: Myb/SANT
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: Contains a single Myb-like domain with an insertion in the middle. It is ambiguous whether Myb-like domains are DNA or protein binding. Since it has a single domain it's likely non-specific.
SL notes: Contains a single Myb-like domain with an insertion in the middle. It is ambiguous whether Myb-like domains are DNA or protein binding. Since it has a single domain it's likely non-specific, but future experiments should be performed to assay it's specificity 
Reviewer 1 (Laura Campitelli) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: The protein contains a Myb-like-domain (see InterPro and Pfam); so it could poteintially bind to DNA in a sequence-specific manner
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: MYB (ENSG00000118513)
DNA-binding domain: Myb/SANT
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: In vivo/Misc source
Notes: Only known motifs are from Transfac or HocoMoco - origin is uncertain
Comments: Contains 3 Myb DBDs
SL notes: Contains 3 Myb DBDs
Reviewer 1 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12244173;15691758
Annotated as a GO transcription factor: Yes
PDB structure: 1MSE
Gene: MYBL1 (ENSG00000185697)
DNA-binding domain: Myb/SANT
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Comments: Contains 3 Myb DBDs
SL notes: Contains 3 Myb DBDs
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7987850
Annotated as a GO transcription factor: Yes
Gene: MYBL2 (ENSG00000101057)
DNA-binding domain: Myb/SANT
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Comments: Contains 3 Myb DBDs
SL notes: Contains 3 Myb DBDs
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Matt Weirauch) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1861984;8631934;11997503
Annotated as a GO transcription factor: Yes
Gene: MYPOP (ENSG00000176182)
DNA-binding domain: Myb/SANT
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Comments: Contains a single Myb-like domain. Mouse ortholog has motif 
SL notes: Contains a single Myb-like domain. Mouse ortholog has motif 
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 notes: Weirauch et al has a model for the mouse ortholog
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 comment: dimerizes with PFN1
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: MYSM1 (ENSG00000162601)
DNA-binding domain: Myb/SANT
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: MYSM1 has been shown to bind DNA. This interaction requires the MYSM1 Myb but not the SWIRM domain (PMID: 17428495). Domain sequence alignment places it near DNA-binding Myb domains but scores slightly higher as a SANT rather than Myb domain based on Prosite patterns. Given that most Myb proteins that bind DNA sequence specifically have multiple Myb domains in an array, this protein could bind DNA sequence non-specifically with its single Myb domain.
SL notes: MYSM1 has been shown to bind DNA ? interaction with DNA requires the MYSM1 Myb but not the SWIRM domain (PMID:17428495). Domain sequence alignment places it near DNA-binding Myb domains but scores slightly higher as a SANT rather than Myb domain based on Prosite patterns. Given that most Myb proteins that bind DNA sequence specifically have multiple Myb domains in an array this protein could bind DNA sequence non-specifically with it?s single Myb domain. Future experiments should assay MYSM1?s specificity 
Disagreement on binding: Disagree
Reviewer 1 (Sam Lambert) assessment: Likely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Contains both a Myb domain; and SWIRM domain (yeast SWIRM domain has been shown to bind DNA through a helix-turn-helix motif; PMID: 16461455). The MYSM SWIRM is not required for DNA-binding (PMID:17428495); but the Myb domain is. 
Reviewer 2 (Laura Campitelli) assessment: Likely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Specifically deubiquitinates monoubiquitinated histone H2A - role in histone modification [PMID: 17707232]
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: NCOR1 (ENSG00000141027)
DNA-binding domain: Myb/SANT
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Contains 2 SANT domains, and no other putative DNA-binding domains. Member of N-CoR deacetylase complex (PMID: 14527417).
SL notes: Contains 2 SANT domains, and no other putative DNA-binding domains 
Disagreement on assessment: Disagree
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Works as a transcriptional co-repressor for several TFs
Reviewer 2 (Laura Campitelli) assessment: Likely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: Member of N-CoR deacetylase complex [PMID: 14527417]
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding; Transcription Regulatory Activity: heterochromatin interaction/binding_TF PPI_PMIDS:11997503;12628926
Annotated as a GO transcription factor: No
Gene: NCOR2 (ENSG00000196498)
DNA-binding domain: Myb/SANT
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Contains 2 SANT domains, and no other putative DNA-binding domains 
SL notes: Contains 2 SANT domains, and no other putative DNA-binding domains 
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: TF-cofactor
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: From Structural Genomics Consortium (PDB:2ltp; http://www.thesgc.org/structures/2ltp): Nuclear receptor corepressor 2 (NCoR2) is a transcriptional regulator involved in the repression of nuclear receptors such as the thyroid hormone receptor and the 
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: PRDM11 (ENSG00000019485)
DNA-binding domain: Myb/SANT
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: SANT domain containing protein. Mouse Prdm11 contains Myb-like domain and binds DNA in PBM experiments but has low sequence identity (21%) 
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Transcript ENST00000534751 has SANT/MYB domain  IPR001005 that binds DNA based on PBM
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: SANT domain containing protein. Mouse Prdm11 contains Myb-like domain and binds DNA in PBM experiments but has low sequence identity (21%) 
CisBP considers it a TF: #N/A
TFclass considers it a TF: #N/A
TF-CAT classification: #N/A
Annotated as a GO transcription factor: #N/A
PDB structure: #N/A
Gene: RCOR1 (ENSG00000089902)
DNA-binding domain: Myb/SANT
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Contains 2 SANT domains, and no other putative DNA-binding domains. Plays a well-established co-repressor role in the histone LSD1/RCOR1 de-methylase complex. There is some evidence that the protein contacts extranucleosomal DNA (PMID: 25916846).
SL notes: Contains 2 SANT domains, and no other putative DNA-binding domains 
Disagreement on binding: Disagree
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Has a Myb-like domain and could thus be a DNA-binding domain; it has however well established co-repressor role in histone LSD1/RCOR1 de-methylase complex. There is some evidence that the protein contacts extranucleosomal DNA PMID: 25916846.
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: RCOR2 (ENSG00000167771)
DNA-binding domain: Myb/SANT
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Contains 2 SANT domains, and no other putative DNA-binding domains 
SL notes: Contains 2 SANT domains, and no other putative DNA-binding domains 
Disagreement on binding: Disagree
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: There is no evidence for direct sequence specific DNA binding activity
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: SANT protein
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:10449787;16079794
Annotated as a GO transcription factor: Yes
Gene: RCOR3 (ENSG00000117625)
DNA-binding domain: Myb/SANT
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Contains 2 SANT domains, and no other putative DNA-binding domains. RCOR3 SANT domains are known to facilitate PPIs. Known co-repressor - likely recruited by multiple TFs, as reviewed in (PMID: 24820421).  
SL notes: Contains 2 SANT domains, and no other putative DNA-binding domains. RCOR3 SANT domains are known to facilitate PPIs
Reviewer 1 (Tim Hughes) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Known co-repressor; likely recruited by multiple TFs; as reviewed in the introduction of PMID:24820421.  The Myb/SANT domains are known to have functions that are not DNA binding.  From PMID:24820421:  "The ELM2 and the first SANT domain (SANT1) part
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: SMARCA1 (ENSG00000102038)
DNA-binding domain: Myb/SANT
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: SMARCA1 contains a truncated Myb-like and SANT domain. Given the presence of the Myb-like domain, and other domains known to associated with DNA (DEAD box helicase) it likely associates with DNA non-sequence-specifically
SL notes: SMARCA1 contains a truncated Myb-like and SANT domain. Given the presence of the Myb-like domain, and other domains known to associated with DNA (DEAD box helicase) it likely associates with DNA non-sequence-specifically
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 notes: chromatin modifier; multiple domains that could bind to DNA; should be tested
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_DNA Binding_PMIDS:1408766;10415348;11031099
Annotated as a GO transcription factor: No
Gene: SMARCA5 (ENSG00000153147)
DNA-binding domain: Myb/SANT
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Notes: Has a putative AT-hook
Comments: Contains a SANT, and Myb-like domain. Chromatin remodeling complex component that operates in DNA repair (PMID: 24990377); interacts with DNA, but presumably in non-sequence specific manner.
SL notes: Contains a SANT, and Myb-like domain
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Chromatin remodelling complex component that operates in DNA repair PMID: 24990377; interacts with DNA but presumably in non-sequence specific manner
Reviewer 2 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding; DNA-Binding: non-sequence-specific_Non-specific DNA_PMIDS:12368916
Annotated as a GO transcription factor: No
Gene: SMARCC1 (ENSG00000173473)
DNA-binding domain: Myb/SANT
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Contains 1 SANT domain, and no other putative DNA-binding domains. Given that SMARCC1 is part of the Swi/Snf chromatin remodelling complex, its Myb/Sant domain is likely involved in binding histone tails. Available motif logos ares likely specificifities of SMARCC1 interactors.
SL notes: Contains 1 SANT domain, and no other putative DNA-binding domains. Motif logos look like bZIP dimeric binding sites, and are thus likely specificifities of SMARCC1 interactors
Disagreement on assessment: Disagree
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: The current motif models (ChIP-seq and Hocomoco) are incorrect and are clearly bZIP dimeric sites. Given that SMARCC1 is part of the Swi/Snf chromatin remodelling complex it's Myb/Sant domain is likely involved in binding histone tails - although no 
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene Candidate_Transcription Factor Binding: tf co-factor binding; Transcription Regulatory Activity: heterochromatin interaction/binding_TF PPI; Transactivation_PMIDS:15923603;11018012
Annotated as a GO transcription factor: No
Gene: SMARCC2 (ENSG00000139613)
DNA-binding domain: Myb/SANT
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Contains 1 SANT domain, and no other putative DNA-binding domains. Available motif logos ares likely specificifities of SMARCC2 interactors.
SL notes: Contains 1 SANT domain, and no other putative DNA-binding domains. Motif logos ares likely specificifities of SMARCC2 interactors
Disagreement on binding: Disagree
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Motifs are suspect; one of them is likely ZNF143 target site. Protein is a chromatin remodelling complex
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 notes: Perhaps needs a revisit
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: SNAPC4 (ENSG00000165684)
DNA-binding domain: Myb/SANT
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Comments: EMSA data available showing it can specifically bind DNA (PMID: 9418884)
SL notes: Contains only Myb DBDs
Reviewer 1 (Matt Weirauch) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: EMSA showing it can specifically bind DNA: PMID 9418884
Reviewer 2 (Sam Lambert) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: SNAP4C binds specific DNA elements (PMID: 12621023; 15955816). A crystal exists of a SNAPC4/Oct-1 bound to DNA but the structure has not been solved (PMID:11856838).
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: non-sequence-specific; Basal Transcription Factor; Transcription Factor Binding: tf co-factor binding_Co-activation; DNA Binding; TF PPI_PMIDS:9418884
Annotated as a GO transcription factor: Yes
Gene: TADA2A (ENSG00000276234)
DNA-binding domain: Myb/SANT
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: TADA2A contains a single SANT domain and is thus unlikely to bind DNA 
SL notes: Contains 1 SANT domain
Reviewer 1 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 notes: Homeo-like and SANT domains; check amino-acids required for binding
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: TADA2B (ENSG00000173011)
DNA-binding domain: Myb/SANT
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: TADA2B contains a single SANT domain and is thus unlikely to bind DNA 
SL notes: TADA2B contains a single SANT domain and is thus unlikely to bind DNA 
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 notes: Homeo-like domain; check amino-acids required for binding
Reviewer 2 (Sam Lambert) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: Adaptor protein that contains Myb domain which has protein-binding potential in addition to being a canonical DBD. Labelled Class 1 based on the absence of evidence against this protein binding DNA
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: TERB1 (ENSG00000249961)
DNA-binding domain: Myb/SANT
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Comments: Contains a single Myb domain (with slightly less similarity to a SANT domain). This domain has been shown to be involved in PPIs (PMID: 24413433), but this may not be mutually exclusive with DNA-binding.
SL notes: Contains a  single Myb domain (with slightly less simialrity to a SANT domain.) This domain has been shown to be involved in PPIs but this may not be mutually exclusive with DNA-binding. The sequence-specificity of CCDC79 should be investigated in the future
Reviewer 1 (Sam Lambert) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: TERB1 contains a Myb domain which are canonically thought to be a DBD. Experimental evidence shows that the TERB1 Myb has PPI activity with SA3 (PMID:24413433); but also mention that this may not be mutually exclusive from DNA-binding activity (PMID:
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: TERF1 (ENSG00000147601)
DNA-binding domain: Myb/SANT
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Comments: Contains 1 Myb domain, and has structural evidence of DNA-binding (PDB: 1IV6). Subunit of Shelterin, a complex that specifically binds telomeres (PMID: 16166375).
SL notes: Contains 1 Myb domain, and has structural evidence of DNA-binding 
Reviewer 1 (Matt Weirauch) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Solved crystal structure in complex with DNA: 1IV6
Reviewer 2 (Laura Campitelli) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: Subunit of Shelterin; a complex that specifically binds telomeres [PMID 16166375]
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
PDB structure: 1IV6