Jerryhuang001/TF_network huggingface dataset:
Gene: SUPT6H (ENSG00000109111)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: SPT6 is an elongation factor, not a TF.  GO needs to be corrected - (PMID: 8786132) does not demonstrate sequence specificity or DNA binding.
Reviewer 1 (Tim Hughes) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: SPT6 is an elongation factor; not a TF.  GO needs to be corrected - PMID:8786132 does not demonstrate sequence specificity or DNA binding.
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: May regulate transcription through establishment or maintenance of chromatin structure [PMID: 8786132]
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: Not a TF - Evidence that it is not a TF___PMIDS:0
Annotated as a GO transcription factor: Yes
Gene: SUV39H1 (ENSG00000101945)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Protein is a histone methyltransferase that trimethylates lysine 9 of histone H3
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Protein is a histone methyltransferase that trimethylates lysine 9 of histone H3
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:15107829
Annotated as a GO transcription factor: No
Gene: SUV39H2 (ENSG00000152455)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Histone (H3K9) methyltransferase. Also directs DNA methylation (UniProt: Q9H5I1) (PMID: 14765126)
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Protein is a testis specific histone H3 methyltransferase PMID: 11094092
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Histone (H3K9) methyltransferase; also directs DNA methylation (UniProt: Q9H5I1) [PMID: 14765126]
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene Candidate_Transcription Factor Binding: tf co-factor binding; Transcription Regulatory Activity: heterochromatin interaction/binding_Other_PMIDS:11094092;15107829
Annotated as a GO transcription factor: No
Gene: SUZ12 (ENSG00000178691)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: Protein is a component of the PRC2 repressor complex, which silences DNA through histone methylation. The protein has two znf C2H2-like domains that appear to be used in association with chromatin (PMID: 24100017)
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Protein is a component of PRC2 repressor complex that silences DNA through histone methylation. The protein has two znf C2H2 like domains that appears to be used in association with chromatin PMID: 24100017
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding_DNA Binding_PMIDS:15225548;16751344
Annotated as a GO transcription factor: No
Gene: SYK (ENSG00000165025)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Known co-factor
Reviewer 1 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: cofactor
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: TAB1 (ENSG00000100324)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: TAB2 (ENSG00000055208)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Works as a protein-protein interaction adapter to recruit TAK1-kinase (PMID: 10882101). Could also work as an RBP, based on presence of a zf-RanBP domain
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Based on PMID: 10882101 it works as an protein-protein interaction adapter to recruit TAK1-kinase. Could also work as an RBP based on it containing a zf-RanBP domain
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: TAB3 (ENSG00000157625)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: TADA3 (ENSG00000171148)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Notes: Has a putative AT-hook
Comments: Paper cited by GO annotation has no evidence of specific DNA-binding activity (PMID: 9674425), and is based on experiments using an entire complex 
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: GO annotation has no evidence of specific DNA-binding activity (PMID:9674425); and is based on experiments using an entire complex 
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Indeterminate case. Paper cited here [PMID:9674425] didn't show any evidece about the direct interaction of TADA3 with DNA and I didn't find evidence from nowhere.
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:12034840
Annotated as a GO transcription factor: Yes
Gene: TAF1 (ENSG00000147133)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: In vivo/Misc source
Notes: Only known motifs are from Transfac or HocoMoco - origin is uncertain
Comments: Contacts DNA in the structure (PDB: 5FUR).  Transfac motifs are suspect, and are probably in vivo signals derived from promoter binding TFs (e.g. YY1 and ETS)
Committee notes: Transfac motifs are suspect; probably in vivo signals derived from promoter binding TFs; at least YY and ETS
Disagreement on binding: Disagree
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Transfac motifs are suspect; probably in vivo signals derived from promoter binding TFs; at least YY and ETS
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
PDB structure: 5FUR
Gene: TAF10 (ENSG00000166337)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: General transcription factor
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: GTF
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: General transcription factor
Reviewer 2 notes: possible TATA recognition?
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene Candidate_Transcription Factor Binding: tf co-factor binding; Basal Transcription Factor_TF PPI; Transactivation_PMIDS:7923369
Annotated as a GO transcription factor: Yes
Gene: TAF11 (ENSG00000064995)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Does not interact with DNA (PMID: 15657423)
Reviewer 1 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: PMID: 15657423
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Basal Transcription Factor; Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:8670810;9108034
Annotated as a GO transcription factor: No
Gene: TAF12 (ENSG00000120656)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: (PMID: 15601843) shows it has DNA binding activity in a complex with TAF4b.
Committee notes: Related to histone H2B.  PMID: 15601843 shows DNA binding activity in complex with TAF4b, but does not demonstrate intrinsic sequence specificity.  
Disagreement on binding: Disagree
Reviewer 1 (Laura Campitelli) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 
Reviewer 2 comment: PMID: 15601843 says it has DNA binding activity in complex with TAF4b.
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Basal Transcription Factor; Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:7729427;15735663
Annotated as a GO transcription factor: Yes
Gene: TAF13 (ENSG00000197780)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: Forms heterodimer TAF11:TAF13, which has a histone-fold like structure and could thus bind DNA in a non- or low specific manner (PMID: 9695952)
Committee notes: Forms heterodimer TAF11:TAF13 that has histone-fold like structure and could thus bind DNA in a non- or low specific manner PMID: 9695952
Disagreement on binding: Disagree
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Forms heterodimer TAF11:TAF13 that has histone-fold like structure and could thus bind DNA in a non- or low specific manner PMID: 9695952
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 2 Obligate heteromer
Reviewer 2 comment: PMID: 15657423 says TAF13 heterodimerize with TAF11 and enhances TBP + TFIIA DNA binding.
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: TAF1A (ENSG00000143498)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: General TF. Directly binds to DNA, likely in a non sequence-specific manner (PMID: 15970593), although it is possible it might have some specificity.
Committee notes: Literature is confusing - involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.  Presumably must bind DNA non-specifically but hard to find direct statement.
Disagreement on assessment: Disagree
Reviewer 1 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 notes: Are we counting GTFs as sequence-specific TFs?
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: it's a TF and could direclty bind to DNA in a sequence-specific manner. [PMID: 15970593]
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Basal Transcription Factor__PMIDS:0;8013460
Annotated as a GO transcription factor: No
Gene: TAF1B (ENSG00000115750)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: Pol I TAF that contacts the rDNA promoter in conjunction with TBP and UBF (PMID: 7491500).  No clear evidence that it directly confers sequence specificity.
Reviewer 1 (Tim Hughes) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Pol I TAF that contacts the rDNA promoter but does so in conjunction with TBP and UBF (PMID:7491500).  I do not see evidence that it directly confers sequence specificity; however.
Reviewer 2 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: Based on PMID: 21921199 it is likely to contact the DNA in RNA polymerase I preinitiation complex
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: Not a TF - Evidence that it is not a TF___PMIDS:0
Annotated as a GO transcription factor: Yes
Gene: TAF1C (ENSG00000103168)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC.
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: taf
Reviewer 2 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Basal Transcription Factor_TF PPI_PMIDS:7801123;9050847
Annotated as a GO transcription factor: No
Gene: TAF1L (ENSG00000122728)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: Involved in preinitiation complex assembly (general transcriptional machinery. Is a paralog of TAF1, which binds DNA based on the structure (PDB: 5FUR)
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Is paralog of TAF1; that binds DNA based on structure PDB:5FUR
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: Involved in preinitiation complex assembly (general transcription)
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:7590250
Annotated as a GO transcription factor: Yes
Gene: TAF2 (ENSG00000064313)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: Directly contact with DNA in TFIID complex (PMID: 27096372), and mediate major interactions with the downstream promoter together with TAF1. Contacts DNA in the structure (PDB: 5FUR)
Committee notes: Directly contact with DNA in TFIID complex [PMID: 27096372] and mediate major interactions with dwonstream promoter together with TAF1.
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: General transcription factor
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 2 Obligate heteromer
Reviewer 2 comment: Directly contact with DNA in TFIID complex [PMID: 27096372] and mediate major interactions with dwonstream promoter together with TAF1.
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Basal Transcription Factor_TF PPI_PMIDS:9774672
Annotated as a GO transcription factor: Yes
PDB structure: 5FUR
Gene: TAF3 (ENSG00000165632)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Contacts chromatin through modified histones and TFs such as TP53 (PMID: 18549481)
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Contacts chromatin through modified histones and TFs such as TP53 PMID: 18549481
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Basal Transcription Factor_TF PPI_PMIDS:11438666
Annotated as a GO transcription factor: Yes
Gene: TAF4 (ENSG00000130699)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: The TAF4 domain interacts with TAF12 and makes a novel histone-like heterodimer that binds DNA and has a core promoter function for of a subset of genes (PMID: 19635797; PMID: 12237304)
Reviewer 1 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: From Interpro: TAF4 domain interacts with TAF12 and makes a novel histone-like heterodimer that binds DNA and has a core promoter function of a subset of genes (PMIDs:19635797;12237304)
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: TAF4B (ENSG00000141384)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: Histone-like protein that binds DNA as an obligate heterodimeric complex with TAF12 (PMID: 19635797). Target sequence needs to be over 70 bases long and doesn't appear to have sequence specificity
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Histone like protein that binds DNA as obligate heterodimeric complex with TAF12 based on PMID: 19635797; target sequence needs to be over 70 bases long but doesn't appear to have sequence specificity
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: DNA-binding activity has been shown (PMID:15601843); however no evidence supports sequence-specificity 
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:11557891;16473943
Annotated as a GO transcription factor: No
Gene: TAF5 (ENSG00000148835)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: TAF5L (ENSG00000135801)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Paralog of TAF5 that is unlikely to contact DNA (PMID: 17227857)
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Based on PMID: 17227857 it's paralog TAF5 is unlikely to contact the DNA
Reviewer 2 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: TAF6 (ENSG00000106290)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Does not contact DNA in the structure (PDB: 5FUR)
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: TAFII complex binds DNA; but no specific contacts of TAF6 with DNA were demonstrated (PMID:9603525; PMID:27007846)
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Indeterminate case. TBP (TATA binding protein) free TAF complex could bind to DNA in a sequence specific manner; but no evidence showed TAF6 could bind to DNA
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Basal Transcription Factor_TF PPI_PMIDS:7667268
Annotated as a GO transcription factor: Yes
PDB structure: 5FUR
Gene: TAF6L (ENSG00000162227)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Part of the PCAF Histone Acetylase Complex (PMID: 9674425). Structurally similar to TAF6, which does not contact DNA directly
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Part of the PCAF Histone Acetylase Complex (PMID:9674425)
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding_TF PPI_PMIDS:9674425
Annotated as a GO transcription factor: No