Jerryhuang001/TF_network huggingface dataset:
Gene: FLNA (ENSG00000196924)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Go annotation is based on (PMID: 15684392), which shows that it binds FOXC1 and PBX1 but doesn't show evidence for binding to DNA
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Go annotation is based on PMID: 15684392 which shows that it binds FOXC1 and PBX1 but doesn't show evidence for binding to DNA
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: FMNL2 (ENSG00000157827)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: FUBP1 (ENSG00000162613)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Notes: Only known motifs are from Transfac or HocoMoco - origin is uncertain
Comments: ssDNA binding protein with crystal structure demonstrating binding to ssDNA (PDB: 1J4W). It's a KH domain protein - this is Leven's protein, known to impact the Myc promoter.
Committee notes: ssDNA binding protein with crystal structure binding ssDNA, and binds to specific genomic loci.  It's a KH domain protein - this is Leven's protein, known to impact the Myc promoter.
Reviewer 1 (Matt Weirauch) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Crystal structure shows it binds ssDNA
Reviewer 1 notes: Yes - what to do when the only evidence is for ssDNA?
Reviewer 2 (Laura Campitelli) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: Binds specific genomic loci [PMID: 8125259]
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
PDB structure: 1J4W
Gene: FUBP3 (ENSG00000107164)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Can bind single stranded DNA in a sequence specific manner (PMID: 8940189). Contans KH domains and has direct evidence it is an RNA-binding protein (PMID: 21252297)
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Based on the presence of KH domains and direct evidence it is a RNA-binding protein PMID: 21252297
Reviewer 1 notes: Based on 8940189 it can bind single stranded DNA in a sequence specific manner
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: PMID: 8940189 suggest about sequence specific DNA binding(Fig. 5).
Reviewer 2 notes: single-strand DNA-binding transactivators
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: FUS (ENSG00000089280)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: FUS is a well-established RNA-binding protein 
Reviewer 1 (Tim Hughes) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: This is a known RNA binding protein and lacks DBDs.  It is included only because TFcat categorizes it as a cofactor.
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: FUS is a well-established RNA-binding protein 
Reviewer 2 notes: Missing domain logos  
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:11278855
Annotated as a GO transcription factor: No
Gene: FZD1 (ENSG00000157240)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: FZD2 (ENSG00000180340)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Transmembrane receptor protein that operates far upstream in the signalling cascade
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Transmembrane receptor protein that operates far upstream in the signalling cascade
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: FZD4 (ENSG00000174804)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: FZD6 (ENSG00000164930)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: GABPB1 (ENSG00000104064)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Notes: Only known motifs are from Transfac or HocoMoco - origin is uncertain
Comments: Evidence exists showing that GABPB1 (E4TF1-47/53) has no DNA binding activity, but can assocaite with GABPA (E4TF1-60; Ets factor) (PMID: 8441384). Crystal structure of GAPBP1 with GABPA (PDB: 1AWC)  clearly shows that the protein makes an extensive protein-protein interaction with GABPA, but does not bind DNA. Transfac PWM is a clear ETS-motif, so GABP1 is unlikely to contact DNA directly
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Laura Campitelli) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 2 Obligate heteromer
Reviewer 2 comment: Evidence showed that GABPB1 ( E4TF1-47/53) has no DNA binding activity; but can assocaite with GABPA [E4TF1-60; Ets factor].  [PMID: 8441384]
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
PDB structure: 1AWC
Gene: GABPB2 (ENSG00000143458)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Obligate heteromer with GABPB1 (the alpha subunit) (PMID: 8810337), which together interact with GABPA (PMID: 8441384), but neither contacts the DNA
Disagreement on assessment: Disagree
Reviewer 1 (Matt Weirauch) assessment: Likely to be sequence specific TF; binding: 2 Obligate heteromer
Reviewer 1 comment: Obligate heteromer with GABPB1 (the alpha subunit): 8810337
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 2 Obligate heteromer
Reviewer 2 comment: See evidence for GABPB1
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: GADD45A (ENSG00000116717)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Doesn't have any DBDs - likely a co-factor 
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Doesn't have any DBDs; likely a co-factor 
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:10872826
Annotated as a GO transcription factor: No
Gene: GAS6 (ENSG00000183087)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: GAS7 (ENSG00000007237)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: (PMID: 9736752) only shows that it has a proline-rich domain similar to the one in Oct2.  No evidence of DNA binding.
Reviewer 1 (Tim Hughes) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: PMID:9736752 only shows that it has a proline-rich domain similar to the one in Oct2.  No evidence of DNA binding.
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Source of GO annotation has no evidence for DNA-binding activity (PMID:9736752)
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: GCFC2 (ENSG00000005436)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: There is some evidence that this protein is an RNA-binding protein (PMID: 24304693).
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: There is some evidence that this protein is a RNA-binding protein PMID: 24304693; based on entrez-summary the name of the protein is a mistake "A positively charged amino terminus present only in the chimera was determined to bind GC-rich DNA; thus m
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: GEN1 (ENSG00000178295)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: Resolves Holliday junctions. Binds DNA in the crystal structure (PDB: 5T9J)
TRH notes: GEN1, Holliday junction 5' flap endonuclease 
AJ notes: 5T9J
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Binds DNA in the crystal structure; PDB: 5T9J
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: Resolves Holliday junctions
TFclass considers it a TF: No
Gene: GLMP (ENSG00000198715)
DNA-binding domain: Unknown
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Comments: Binds GATCCGCCCGCTTGTGGCCAACTGGCTCCAGTCAC dsDNA based on EMSA (PMID: 18021396)
Reviewer 1 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Binds GATCCGCCCGCTTGTGGCCAACTGGCTCCAGTCAC dsDNA based on EMSA PMID: 18021396
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: GOLGB1 (ENSG00000173230)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Golgi resident transmembrane protein that regulates glycosylation of other proteins (PMID: 27226319)
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Golgi resident transmembrane protein that regulates glycosylation of other proteins PMID: 27226319
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: GON4L (ENSG00000116580)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Prosite identifies a low-confidence Myb-like domain (e.g., can't decide between Myb, SANT, or no DBD), so it's probably not a TF
SL notes: "Prosite identifies a low-confidence Myb-like domain (e.g. can?t decide between Myb and SANT) so it?s probably not a TF"
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 notes: MYB-like domain; check for residues required for DNA binding
Reviewer 2 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: GPATCH8 (ENSG00000186566)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: GPBP1 (ENSG00000062194)
DNA-binding domain: Unknown
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Comments: Solid data presented in (PMID: 14612417) Also known as "Vasculin".  (PMID: 26156556) also claims it has an "extended AT hook".
Committee notes: PMID 14612417 looks pretty solid - surprising there hasn't been more since.  It's also known as "Vasculin".  PMID 26156556 also claims it has an "extended AT hook".
Reviewer 1 (Matt Weirauch) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Looks like a legitimate "non-traditional" TF: 14612417
Reviewer 2 (Laura Campitelli) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: Murine homolog is a promoter-specific TF [PMID: 14612417]
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: GPBP1L1 (ENSG00000159592)
DNA-binding domain: Unknown
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Comments: Possible TF based on similarity to GPBP1. Despite its name, no available evidence for DNA binding. Could also be an RBP according to this screen (PMID: 22658674)
Reviewer 1 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Despite its name; I could find no evidence for it binding DNA. Could be an RBP according to this screen: PMID 22658674
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: GPER1 (ENSG00000164850)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: GPR155 (ENSG00000163328)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: GREM1 (ENSG00000166923)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
TFclass considers it a TF: No
Gene: GRM6 (ENSG00000113262)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: GTF2A1 (ENSG00000165417)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: General transcription factor. Binds DNA in the crystal structure (PDB: 5FUR). The protein contacts the DNA backbone as a heterotrimeric complex that also includes GTF2A2 and TBP. Has an extensive protein-protein interaction interface with the GTF2A2 (that does not contact the DNA) and will probably do nothing without it
TRH notes: general transcription factor IIA subunit 1 
AJ notes: 5FUR
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: General transcription factor;Binds DNA in the crystal structure PDB: 5FUR, The protein contacts DNA backbone as a heterotrimeric complex that also has GTF2A2 and TBP, Has extensive protein-protein interaction interface with the GTF2A2 (that does not contact the DNA) and will probably do nothing without it
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: Contacts DNA backbone (PBD:5FUR)
TFclass considers it a TF: No
Gene: GTF2A1L (ENSG00000242441)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Basal Transcription Factor_Co-activation_PMIDS:12107178
Annotated as a GO transcription factor: No
Gene: GTF2A2 (ENSG00000140307)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: GTF2A2 makes contacts with the DNA backbone (PDB:1NVP; PMID: 12972251), and thus is unlikely to be sequence-specific 
Disagreement on binding: Disagree
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: GTF2A2 makes contacts with the DNA backbone (PDB:1NVP; PMID: 12972251); thus is unlikely to be sequence-specific 
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
PDB structure: 1NVP
Gene: GTF2B (ENSG00000137947)
DNA-binding domain: Unknown
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 3 Low specificity DNA-binding protein
Motif status: In vivo/Misc source
Notes: Only known motifs are from Transfac or HocoMoco - origin is uncertain
Comments: Contacts both DNA and TBP in the structure (PDB: 1C9B)
Committee notes: (one degree of seperation away from the DNA): DNA-TFIId-GTF2B
Reviewer 1 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: (one degree of seperation away from the DNA): DNA-TFIId-GTF2B
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 notes: Are we counting GTFs as sequence-specific TFs?
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding; Basal Transcription Factor_TF PPI_PMIDS:12972613;15037660;1729710;1922364;15749018;8621548;9420329;10546889
Annotated as a GO transcription factor: No
PDB structure: 1C9B