Jerryhuang001/TF_network huggingface dataset:
Gene: TSC22D4 (ENSG00000166925)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: There is some evidence that a related protein (TSC22D1) binds DNA specifically - thus, it is possible this is also a TF.
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: TSC22 Domain has not been conclusively shown to bind DNA sequence-specifically
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: a transcriptional regulator which seems to act on C-type natriuretic peptide (CNP) promoter [PUBMED:9022669]. 
CisBP considers it a TF: No
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: TSN (ENSG00000211460)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: Based on (PMID: 20450889) and (PMID: 12484770), this protein binds repetitive DNA sequences as multimeric complexes that may contain partner protein TSNAX
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Based on PMID: 20450889 and PMID: 12484770 this protein binds repetitive DNA sequences as multimeric complexes that may contain partner protein TSNAX
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: Indeterminate - There is no evidence for or against this genes role as a TF__DNA Binding_PMIDS:9159125;10434033
Annotated as a GO transcription factor: No
Gene: TSSK4 (ENSG00000139908)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: TUB (ENSG00000166402)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: The Tubby C-terminal domain (IPR000007; PF01167) has been shown to impart nuclear localization and bind select dsDNA sequences in gel-shift experiments (PMID: 10591637). This article hypothesized that this domain constitutes a bona fide sequence specific TF, but no concrete evidence for this exists to date
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: The Tubby C-terminal domain (IPR000007; PF01167) has been shown to impart nuclear localization and bind select dsDNA sequences in gel-shift experiments (PMID:10591637). This article hypothesized that this domain constitutes a bona fide sequence speci
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: PMID: 10591637 says that tub  domain; becaus of it s surface charge; may bind ds DNA
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: TULP4 (ENSG00000130338)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: (PMID: 10591637) shows that it binds dsDNA.  All other research, however, supports phosphoinositide-binding as the major function of the tubby domain.
Committee notes: PMID: 10591637 shows that it binds dsDNA.  All other research, however, supports phosphoinositide-binding as the major function of the tubby domain.
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 
Reviewer 2 comment: PMID: 10591637 suggest that these are TFs
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: TUT1 (ENSG00000149016)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: TXK (ENSG00000074966)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Experimental evidence for DNA-binding was performed with nuclear extract - thus, the apparent specific-binding of TXK could be due to indirect binding (PMID: 11859127). In addition a whitepaper suggests that this interaction could not be replicated (Miskimins, Beth)
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Experimental evidence for DNA-binding was performed with nuclear extract; thus specific-binding of TXK could be due to indirect binding (PMID:11859127). In addition a whitepaper suggests that this interaction could not be replicated (Miskimins; Beth 
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: Indeterminate - There is no evidence for or against this genes role as a TF__DNA Binding_PMIDS:11859127
Annotated as a GO transcription factor: Yes
Gene: U2AF1 (ENSG00000160201)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Well-established RNA binding protein
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: RBP?
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Binds proteins that bind enhancers [PMID: 8647433]
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: U2AF1L4 (ENSG00000161265)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Related to U2AF1, so likely also an RNA binding protein.
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Most likely an RNA-binding protein based on domain content; and literature searches
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: UBA52 (ENSG00000221983)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: UBB (ENSG00000170315)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
PDB structure: 4ZUX
Gene: UBC (ENSG00000150991)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: UBE2K (ENSG00000078140)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: UBE2N (ENSG00000177889)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: UBE2V1 (ENSG00000244687)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Ubiquitin ligase
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Ubiquitin ligase
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: UBN1 (ENSG00000118900)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Interacts with bZIP transcription factors (PMID: 10725330)
Reviewer 1 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Interacts with transcription factors [PMID: 10725330 ]
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: This protein interacts with bZIP transcription factors. However I didn't found any evidence showing it could bind to DNA alone in a sequence specific manner
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: UBR4 (ENSG00000127481)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: UBTFL6 (ENSG00000228970)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Notes: Pseudogene
Comments: According to ENSEMBL this is a Pseudogene, and it is of 'uncertain' confidence in Uniprot. The most similar gene, UBTLF1, is annotated as "No evidence for or against specific DNA-binding by this class of HMG box containing proteins."
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Gene is a pseudogene
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: According to ENSEMBL this is a Pseudogene, and is of 'uncertain' confidence on Uniprot. Most similar to UBTLF1 annotated as "No evidence for or against specific DNA-binding by this class of HMG box containing proteins"
CisBP considers it a TF: #N/A
TFclass considers it a TF: #N/A
TF-CAT classification: #N/A
Annotated as a GO transcription factor: #N/A
PDB structure: #N/A
Gene: UFL1 (ENSG00000014123)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Clearly not a TF based on the papers they cite.
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: UHRF1 (ENSG00000276043)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: Structural evidence (PDB:2ZO0; PDB: 2ZO1; PMID: 18772888] and (PDB: 2ZKE) (PMID: 18772891) demonstrate direct DNA-binding. However, the extent to which it is sequence specific beyond hemimethylated DNA has not been extensively explored.
Committee notes: Structural evidence (PDB:2ZO0; 2ZO1 [PMID:18772888]; and PDB:2ZKE [PMID:18772891]) shows direct binding to methylated CpG
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 notes: chromatin modifier; many of these contain AT hooks or other low specificity DBDs
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: Structural evidence (PDB:2ZO0; 2ZO1 [PMID:18772888]; and PDB:2ZKE [PMID:18772891]) shows direct DNA-binding; the extent to which it is sequence specific beyond hemimethylated DNA has not been extensively explored. GO annotation contains no experiment
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
PDB structure: 2ZO2
Gene: UHRF2 (ENSG00000147854)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: Binds DNA in the crystal structure contacting the minor groove and backbone (PDB: 4PW5).  Recognizes 5hmC-containing DNA (PDB: 4PW5)
TRH notes: ubiquitin like with PHD and ring finger domains 2 
AJ notes: 4PW5
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Binds DNA in the crystal structure contacting the minor groove and backbone PDB: 4PW5
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: SRA domain recognizes 5hmC-containing DNA (PDB:4PW5), and interacts with HDAC1 (PMID:15361834)
TFclass considers it a TF: No
Gene: UNG (ENSG00000076248)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: Involved in mismatch repair. Excises uracil bases from DNA. Binds DNA in the crystal structure (PDB: 1EMJ)
TRH notes: uracil DNA glycosylase 
AJ notes: 1EMJ
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Excises uracil bases from DNA;Binds DNA in the crystal structure; PDB: 1EMJ
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: Involved in mismatch repair
TFclass considers it a TF: No
Gene: USP39 (ENSG00000168883)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: USP7 (ENSG00000187555)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: UTF1 (ENSG00000171794)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:9524124
Annotated as a GO transcription factor: No
Gene: VAV1 (ENSG00000141968)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Paper cited by GO annotation (PMID: 2477241) only presents evidence based on sequence similarity to a ZF motif, and other evidence (PMID: 11994417) only supports a role in coactivation of NFAT and NFKB without direct DNA-binding
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: GO annotation (PMID:2477241) is based on sequence similarity to ZF motif; and other evidence (PMID:11994417) only supports a role in coactivation of NFAT and NFKB without direct DNA-binding
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Paper cited here just suggested VAV1 could be a TF based on amino acids analysis. No direct evidence showing it could bind to DNA in a sequence-specific manner.
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene Candidate__TF PPI; Transactivation_PMIDS:11994417
Annotated as a GO transcription factor: Yes
Gene: VEGFA (ENSG00000112715)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Extracellular signaling molecule.  Included only because it regulates CREB.
Reviewer 1 (Tim Hughes) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Extracellular singling molecule.  Included only because it regulates CREB.
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: VGLL1 (ENSG00000102243)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Likely transcriptional cofactor (PMID: 10518497)
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: TDU repeat likely mediates interactions with other TDU containing proteins involved in transcription
Reviewer 1 notes: Missing domain logos (TDU repeat)
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Likely transcriptional cofactor [PMID: 10518497]
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: VGLL2 (ENSG00000170162)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Co-activator that binds TEF family TFs (PMID: 14762206)
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Co-activator that binds TEF family TFs (PMID:14762206)
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:14762206
Annotated as a GO transcription factor: No
Gene: VGLL3 (ENSG00000206538)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: (PMID: 23380592) describes this protein as  a co-activator, and it doesn't seem to have a DBD (fig. 1)
MTW notes: co-activator for TEA domain proteins (PMID 23380592)
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 notes: annotation missing; seems to be a TEA; check for residues required for DNA binding
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: PMID: 23380592 describe this as  a co-activator and doesn't seem to have a DBD (fig. 1)
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes