Jerryhuang001/TF_network huggingface dataset:
Gene: CREBRF (ENSG00000164463)
DNA-binding domain: bZIP
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Tested on HT-SELEX and did not yield a motif. Binds to CREB3 and represses the unfolded protein response (PMID: 18391022).
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 2 Obligate heteromer
Reviewer 1 comment: Based on PMID: 18391022 it binds to CREB3 and represses the unfolded protein response
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: May repress the transactivation potential of CREB3 by sequestering it in nuclear bodies away from key cofactors (such as HCF-1) that are required for transcriptional activation [PMID: 18391022]
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: CREBZF (ENSG00000137504)
DNA-binding domain: bZIP
Is a transcription factor: Yes
TF assessment: Inferred motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: CREM (ENSG00000095794)
DNA-binding domain: bZIP
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Disagreement on assessment: Disagree
Reviewer 1 (Tim Hughes) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: DBP (ENSG00000105516)
DNA-binding domain: bZIP
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:2331750
Annotated as a GO transcription factor: Yes
Gene: DDIT3 (ENSG00000175197)
DNA-binding domain: bZIP
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 2 Obligate heteromer
Motif status: In vivo/Misc source
Notes: Only known motifs are from Transfac or HocoMoco - origin is uncertain
Comments: Has strong preference for forming heterodimers with BATF; DBP; HLF; CEBP[ABCD] over homodimerization (PMID: 12805554).
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 2 Obligate heteromer
Reviewer 1 comment: Has strong preference for forming heterodimers with BATF; DBP; HLF; CEBP[ABCD] over homodimerization based on Newman et al 2003 pmid:12805554
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 2 Obligate heteromer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:8657121
Annotated as a GO transcription factor: Yes
Gene: FOS (ENSG00000170345)
DNA-binding domain: bZIP
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Matt Weirauch) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8798512;11925568;15073183;2243767
Annotated as a GO transcription factor: Yes
PDB structure: 1A02
Gene: FOSB (ENSG00000125740)
DNA-binding domain: bZIP
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:2498083;14515349;16699069
Annotated as a GO transcription factor: Yes
Gene: FOSL1 (ENSG00000175592)
DNA-binding domain: bZIP
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding_PMIDS:7504176;7791782;15608675
Annotated as a GO transcription factor: Yes
Gene: FOSL2 (ENSG00000075426)
DNA-binding domain: bZIP
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Comments: Also forms heterodimers.
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 2 Obligate heteromer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 2 Obligate heteromer
Reviewer 2 comment: also forms homodimer
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:13679379;15558021
Annotated as a GO transcription factor: Yes
Gene: GULP1 (ENSG00000144366)
DNA-binding domain: bZIP
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: bZIP like region of the protein is just a 33 amino acid fragment
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Truncated bZIP domain - lacks DNA-contacting residues and only contains the leucine zipper portion 
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: HLF (ENSG00000108924)
DNA-binding domain: bZIP
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Tim Hughes) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8065331
Annotated as a GO transcription factor: Yes
Gene: HOOK2 (ENSG00000095066)
DNA-binding domain: bZIP
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding
Reviewer 1 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: IQGAP1 (ENSG00000140575)
DNA-binding domain: bZIP
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: bZIP domain in the protein is  just a fragment.
TRH notes: bZIP domain in the protein is probably just a fragment
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 notes: bZIP domain in the protein is probably just a fragment
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: JDP2 (ENSG00000140044)
DNA-binding domain: bZIP
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI; Transactivation_PMIDS:12052888
Annotated as a GO transcription factor: Yes
Gene: JUN (ENSG00000177606)
DNA-binding domain: bZIP
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12215258;15494506
Annotated as a GO transcription factor: Yes
PDB structure: 1JNM
Gene: JUNB (ENSG00000171223)
DNA-binding domain: bZIP
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Comments: Prefers forming heterodimers with FOS; FOSB; FOSL1 and FOSL2 over homodimers (PMID:12805554); but, clearly can bind DNA specifically in vitro.
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 2 Obligate heteromer
Reviewer 1 comment: Prefers forming heterodimers with FOS; FOSB; FOSL1 and FOSL2 over homodimer; PMID:12805554
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 2 Obligate heteromer
Reviewer 2 comment: JUNB binds as a homodimer in vitro; but is also a well-characterized member of the AP-1 complex with FOS family bZIP TFs and prefers to heterodimerize (PMID:12805554)
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12121977
Annotated as a GO transcription factor: Yes
Gene: JUND (ENSG00000130522)
DNA-binding domain: bZIP
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Tim Hughes) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:2504580
Annotated as a GO transcription factor: Yes
Gene: KIF15 (ENSG00000163808)
DNA-binding domain: bZIP
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Has a bZIP like fragment that lacks the basic region required for DNA binding and a STE-domain that is classified as a potential DBD in CIS-BP. It is a kinesin operating in the microtubule system (PMID: 24419385)
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Has a bZIP like fragment that misses the basic region and a STE-domain that is classified as a DBD in CIS-BP. It is a kinesin operating in the microtubule system PMID: 24419385
Reviewer 2 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: KRT13 (ENSG00000171401)
DNA-binding domain: bZIP
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: MAF (ENSG00000178573)
DNA-binding domain: bZIP
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: MAFA (ENSG00000182759)
DNA-binding domain: bZIP
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15665000
Annotated as a GO transcription factor: Yes
PDB structure: 4EOT
Gene: MAFB (ENSG00000204103)
DNA-binding domain: bZIP
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: 100%ID - in vitro
Comments: PDB:2WTY is a homodimer crystallised with TAATTGCTGACTCAGCAAAT sequence 
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 comment: PDB:2WTY is a homodimer crystallised with TAATTGCTGACTCAGCAAAT sequence 
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:17158225;9571165
Annotated as a GO transcription factor: Yes
PDB structure: 2WTY
Gene: MAFF (ENSG00000185022)
DNA-binding domain: bZIP
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; TF PPI; Transactivation_PMIDS:8107826;12490281
Annotated as a GO transcription factor: Yes
Gene: MAFG (ENSG00000197063)
DNA-binding domain: bZIP
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Other_PMIDS:9421508;15574414
Annotated as a GO transcription factor: Yes
PDB structure: 3A5T
Gene: MAFK (ENSG00000198517)
DNA-binding domain: bZIP
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Other; Transactivation_PMIDS:11013233;14960151
Annotated as a GO transcription factor: Yes
Gene: MORC3 (ENSG00000159256)
DNA-binding domain: bZIP
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Lacks a canonical bZIP DBD but: regulates TP53 activity (PMID: 17332504]), binds RNA in vitro (PMID: 11927593), and may be required for influenza A transcription during viral infection (PMID: 26202233).
MTW notes: binds RNA in vitro [PubMed:11927593
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Lacks canonical DBD but: Regulates TP53 activity [PubMed:17332504]; binds RNA in vitro [PubMed:11927593]; and may be required for influenza A transcription during viral infection [PubMed:26202233]
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: NDC80 (ENSG00000080986)
DNA-binding domain: bZIP
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding
Reviewer 1 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: NFE2 (ENSG00000123405)
DNA-binding domain: bZIP
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8469283
Annotated as a GO transcription factor: Yes
Gene: NFE2L1 (ENSG00000082641)
DNA-binding domain: bZIP
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 2 Obligate heteromer
Motif status: In vivo/Misc source
Notes: Only known motifs are from Transfac or HocoMoco - origin is uncertain
Comments: Tested on HT-SELEX and PBM.  Neither yielded a motif.  Likely an obligate heteromer (PMID: 23661758).
AJ notes: PMID: 23661758
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Tim Hughes) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Matt Weirauch) assessment: Likely to be sequence specific TF; binding: 2 Obligate heteromer
Reviewer 2 comment: Looks like an obligate hetereomer.
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8036168
Annotated as a GO transcription factor: Yes
Gene: NFE2L2 (ENSG00000116044)
DNA-binding domain: bZIP
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 2 Obligate heteromer
Motif status: In vivo/Misc source
Notes: Only known motifs are from Transfac or HocoMoco - origin is uncertain
Comments: Has been tested by both PBM and HT-SELEX.  Neither yielded a motif.  Likely obligate heteromer.
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific__PMIDS:0;
Annotated as a GO transcription factor: Yes
Gene: NFE2L3 (ENSG00000050344)
DNA-binding domain: bZIP
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 2 Obligate heteromer
Motif status: In vivo/Misc source
Notes: Only known motifs are from Transfac or HocoMoco - origin is uncertain
Comments: Tested on HT-SELEX and PBM.  Neither yielded a motif.  Likely an obligate heteromer (PMID: 23661758). Strong preference for forming heterodimers with MAFG and MAFK over homodimers (PMID: 12805554).
AJ notes: PMID: 23661758
Disagreement on assessment: Disagree
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 2 Obligate heteromer
Reviewer 1 comment: Suspect motif. This site is not a bZIP target sequence! Based on pmid:12805554 has strong preference for forming heterodimers with MAFG and MAFK over homodimer based on Newman et al 2003
Reviewer 2 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 2 Obligate heteromer
Reviewer 2 comment: Cant find evidence that it binds DNA; other than as an obligate heteromer.  Failed on both PBMs and SELEX.
Reviewer 2 notes: Might need to revisit - I cant find evidence beyond that supporting it heterodimerizes.
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10037736;15385560
Annotated as a GO transcription factor: Yes
Gene: NFIL3 (ENSG00000165030)
DNA-binding domain: bZIP
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7565758;10074173
Annotated as a GO transcription factor: Yes
Gene: NRBF2 (ENSG00000148572)
DNA-binding domain: bZIP
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Based on the alignments, the protein is only weakly related to the other bZIP proteins and lacks the basic region required for DNA binding
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: likely a cofactor
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No