Jerryhuang001/TF_network huggingface dataset:
Gene: MBD2 (ENSG00000134046)
DNA-binding domain: MBD
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 3 Low specificity DNA-binding protein
Motif status: In vivo/Misc source
Notes: Only known motifs are from Transfac or HocoMoco - origin is uncertain; Has a putative AT-hook
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 3 Low specificity DNA-binding protein
Reviewer 2 (Matt Weirauch) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: I think we agreed that even preference for methylated CpG counts as 'sequence specific'
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding; DNA-Binding: non-sequence-specific_Non-specific DNA; Other_PMIDS:10471499;14610093
Annotated as a GO transcription factor: No
PDB structure: 2KY8
Gene: MBD3 (ENSG00000071655)
DNA-binding domain: MBD
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: The MBD domain of MBD3 is thought to be primarily responsible for interaction with HDAC1 and MTA2, members of the NuRD complex (PMID: 12124384). More recently, studies have shown that it retains the ability to bind methylated CpG sites in vitro (PMID: 24307175) with lower affinity than other MBD proteins (e.g., MBD2), but does not distinguish between hydroxymethylated and unmethylated sites. Coupled with in vivo ChIP experiments, it appears that MBD3 binds unmethylated CpG sites in vivo after being outcompeted by MBD2, and binding has effects on gene expression (PMID: 23361464).
Reviewer 1 (Tim Hughes) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: From the Entrez description:  "Unlike the other family members; the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex."
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: MBD4 (ENSG00000129071)
DNA-binding domain: MBD
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Reviewer 1 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
PDB structure: 2MOE
Gene: MBD6 (ENSG00000166987)
DNA-binding domain: MBD
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: Has not been tested on PBM or HT-SELEX. Some evidence exists showing that it does not bind methylated DNA (PMID: 20700456), and the MBD domain instead facilitates protein interactions (PMID: 24634419). 
Disagreement on binding: Disagree
Reviewer 1 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Ref showing it does not bind methylated DNA: PMID 20700456 ;  Ref showing the MBD domain instead facilitates protein interactions: PMID 24634419 
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: PIN1 (ENSG00000127445)
DNA-binding domain: MBD
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Reviewer 1 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:16227615
Annotated as a GO transcription factor: No
Gene: SETDB1 (ENSG00000143379)
DNA-binding domain: MBD
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 3 Low specificity DNA-binding protein
Motif status: In vivo/Misc source
Notes: Only known motifs are from Transfac or HocoMoco - origin is uncertain
Comments: Transfac motif is dubious.
Disagreement on assessment: Disagree
Reviewer 1 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 notes: motif in Transfac looks wrong
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: Source of Transfac motif is unclear; looks similar to an HT-SELEX motif from the fly MBD TF egg
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:14536086
Annotated as a GO transcription factor: No
Gene: SETDB2 (ENSG00000136169)
DNA-binding domain: MBD
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Reviewer 1 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Not sure how to classify MDB family members.  
Reviewer 1 notes: yes - data unclear
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: BAZ2A (ENSG00000076108)
DNA-binding domain: MBD; AT hook
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: Component of the silencing nucleolar remodelling complex (NoRC) (PMID: 22368283)
Disagreement on assessment: Disagree
Reviewer 1 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Has a methyl-CpG binding domain to recognise CpG methylated DNA additionally to several chromatin binding domains
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: Component of the silencing nucleolar remodelling complex (NoRC) [PMID: 22368283]
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: MECP2 (ENSG00000169057)
DNA-binding domain: MBD; AT hook
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 3 Low specificity DNA-binding protein
Motif status: 100%ID - in vitro
Comments: Binds methylated CpG dinucleotides (PDB: 3C2I)
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Binds methylated CpG dinucleotides in e.g. PDB:3C2I
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding_Non-specific DNA_PMIDS:8177735;9038338
Annotated as a GO transcription factor: No
PDB structure: 3C2I
Gene: MBD1 (ENSG00000141644)
DNA-binding domain: MBD; CxxC ZF
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: Binds CpG methylated DNA (PDB: 1IG4). It is unclear how much other specificity has been defined.
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: Binds CpG methylated DNA in the PDB:1IG4; it is unclear how much other specificity is defined
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_Transcription Regulatory Activity: heterochromatin interaction/binding; DNA-Binding: non-sequence-specific_DNA Binding_PMIDS:15060159;15691849
Annotated as a GO transcription factor: No
PDB structure: 1IG4
Gene: MTERF1 (ENSG00000127989)
DNA-binding domain: mTERF
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: In vivo/Misc source
Notes: Only known motifs are from Transfac or HocoMoco - origin is uncertain
Comments: The structure (PDB: 3MVA) shows a large protein DNA-interaction interface.
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 comment: The structure PDB:3MVA has really big and nice protein DNA-interaction interface
Reviewer 2 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
PDB structure: 3MVA
Gene: MTERF2 (ENSG00000120832)
DNA-binding domain: mTERF
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Reviewer 1 (Tim Hughes) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: mTERF domain - it would have a super long binding site
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: PMID: 21558281
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: MTERF3 (ENSG00000156469)
DNA-binding domain: mTERF
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Comments: Crystral structure available (PMID: 20430012)
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 
Reviewer 1 notes: should this be considered a TF? base flipping etc
Reviewer 2 (Matt Weirauch) assessment: Likely to be sequence specific TF; binding: 
Reviewer 2 comment: crystral structure: 20430012 
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: MTERF4 (ENSG00000122085)
DNA-binding domain: mTERF
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Comments: MTERF4 can bind RNA (PMID: 22949673), but likely to also bind DNA like other mTERF family members.
Reviewer 1 (Matt Weirauch) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: MTERF4 can bind RNA: PMID 22949673.  But; clearly MTERF1 can bind DNA: PMID 17167045; 9118945.  Probably need to test this one.
Reviewer 1 notes: yes - conflicting evidence
Reviewer 2 (Sam Lambert) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: NEB (ENSG00000183091)
DNA-binding domain: mTERF
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Gene Cards/GO indicates that NEB is not present in the nucleus; and it appears to be an actin binding protein highly expressed in muscle.
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Gene Cards/GO predicts that NEB is not present in the nucleus; and it appears to be an actin binding protein highly expressed in muscle
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: C17orf49 (ENSG00000258315)
DNA-binding domain: Myb/SANT
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Contains 1 SANT domain, suggesting it cannot bind DNA specifically
SL notes: Contains 1 SANT domain
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Protein has a MYB-like domain; but nothing more is known about it
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: Member of multiple chromatin-associated complexes [PMID: 25609649]
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: CDC5L (ENSG00000096401)
DNA-binding domain: Myb/SANT
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: In vivo/Misc source
Notes: Only known motifs are from Transfac or HocoMoco - origin is uncertain
Comments: Compelling evidence for DNA binding (PMID: 11082045).
SL notes: Contains 2 Myb DBDs. Sources of Hocomoco/Transfac motifs are unclear. However these sequences look similar to in vitro sites selected by SELEX (PMID:11082045)
Reviewer 1 (Matt Weirauch) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Fairly compelling evidence in this paper: 11082045
Reviewer 2 (Laura Campitelli) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Evidence Conflict - There is evidence for and against this genes role as a TF___PMIDS:0;8917598;9038199;10570151;11082045;8917598;9038199;10570151;11118137
Annotated as a GO transcription factor: Yes
Gene: CHD2 (ENSG00000173575)
DNA-binding domain: Myb/SANT
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Notes: Only known motifs are from Transfac or HocoMoco - origin is uncertain; Has a putative AT-hook
Comments: Although CHD2 has weak similarity to a Myb domain (PMID: 9326634), it's more closely related to the non-DNA-binding SANT domain based on the alignment analysis. The data showing that show that CHD2 binding histone H3.3 (PMID:22569126) further support the conclusion that the Myb domain is probably a SANT domain facilitating the histone interaction
SL notes: Although CHD2 has weak similarity to a Myb domain (PMID:9326634), it's more closely related to the non-DNA-binding SANT domain based on our alignment analysis. The data showing that show that CHD2 binding histone H3.3 (PMID:22569126) further support the conclusion that the Myb domain is probably a SANT domain facilitating the histone interaction
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Has weak similarity to a Myb domain in C-terminus (PMID:9326634)
Reviewer 1 notes: EntrezGene summary is incorrect 
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 comment: PMID: 22569126 says it  interact with MyoD and myogenic gene regulatory sequences
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: CRAMP1 (ENSG00000007545)
DNA-binding domain: Myb/SANT
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Contains a single SANT domain, no evidence for sequence-specific DNA binding 
SL notes: Contains a single SANT domain, no evidence for sequence-specific DNA binding 
Reviewer 1 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Functions as a part of polycomb repressor system and has a single MYB/SANT domain; there is however no evidence for sequence specific binding PMID: 21336627
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
CisBP considers it a TF: No
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: DMTF1 (ENSG00000135164)
DNA-binding domain: Myb/SANT
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Comments: Contains 2 Myb DBDs. Binds to CCCG(G/T)ATGT (PMID: 8887674)
SL notes: Contains 2 Myb DBDs
Reviewer 1 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Binds to CCCG(G/T)ATGT based on PMID: 8887674
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8425553;9786929
Annotated as a GO transcription factor: Yes
Gene: DNAJC1 (ENSG00000136770)
DNA-binding domain: Myb/SANT
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Contains 2 SANT domains, and no other putative DNA-binding domains 
SL notes: Contains 2 SANT domains, and no other putative DNA-binding domains 
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: DNAJC2 could bind DNA in a sequence-specific manner; probably it could also
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: UniProtKB - Q96KC8 says it may bind DNA
Reviewer 2 notes: Revisit necessary.
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: DNAJC2 (ENSG00000105821)
DNA-binding domain: Myb/SANT
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Contains 2 SANT domains, and no other putative DNA-binding domains 
SL notes: Contains 2 SANT domains, and no other putative DNA-binding domains 
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: DNAJC2 (aka ZRF1) likely localizes to chromatin through it's Myb domain and binds H2A (PMID: 21179169) as well as other TFs (e.g RA; PMID: 24292673)
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: Specifically binds to DNA sequence GTCAAGC; which is also preferred by PBX protein
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ELMSAN1 (ENSG00000156030)
DNA-binding domain: Myb/SANT
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Contains a single SANT domain, no evidence for sequence-specific DNA binding 
SL notes: Contains a single SANT domain, no evidence for sequence-specific DNA binding 
Reviewer 1 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 notes: Homeo-like domain; check amino-acids required for binding
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: KIAA1841 (ENSG00000162929)
DNA-binding domain: Myb/SANT
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Domain is truncated, and there is nothing known about this gene 
SL notes: Domain is truncated, and there is nothing known about this gene 
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 notes: graph has Myb domain but IPR domain not called
Reviewer 2 (Laura Campitelli) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: MIER1 (ENSG00000198160)
DNA-binding domain: Myb/SANT
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Contains a single SANT domain, no evidence for sequence-specific DNA binding 
SL notes: Contains a single SANT domain, no evidence for sequence-specific DNA binding 
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: SANT domain has been shown to bind the Sp1 TF and recruit MIER1 indirectly to it's own promoter (PMID:15117948) 
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: MIER2 (ENSG00000105556)
DNA-binding domain: Myb/SANT
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Notes: Has a putative AT-hook
Comments: MIER2's Myb domain is more similar to the non-DNA-binding SANT domain 
SL notes: MIER2's Myb domain is more similar to the non-DNA-binding SANT domain 
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Transcriptional co-repressor that recruits histone deacetylase complex to genes based on similarity to paralog MIER1 PMID: 12482978 Has Myb-like domain so binds DNA and could eve n be sequence specific
Reviewer 2 (Laura Campitelli) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No