Jerryhuang001/TF_network huggingface dataset:
Gene: GCM1 (ENSG00000137270)
DNA-binding domain: GCM
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12682016;15385555
Annotated as a GO transcription factor: Yes
PDB structure: 1ODH
Gene: GCM2 (ENSG00000124827)
DNA-binding domain: GCM
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10671510
Annotated as a GO transcription factor: Yes
Gene: GRHL1 (ENSG00000134317)
DNA-binding domain: Grainyhead
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Matt Weirauch) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12175488
Annotated as a GO transcription factor: Yes
Gene: GRHL2 (ENSG00000083307)
DNA-binding domain: Grainyhead
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: In vivo/Misc source
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 comment: PMID: 25758223; binds similar sites as GRHL1 in ChIP-seq
Reviewer 2 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0
Annotated as a GO transcription factor: Yes
Gene: GRHL3 (ENSG00000158055)
DNA-binding domain: Grainyhead
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Comments: Binds the same AACCGGTT consensus as the paralog GRHL1 based on SELEX (PMID: 21081122).
Reviewer 1 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Binds the same AACCGGTT consensus as the paralog GRHL1 based on SELEX performed by PMID: 21081122
Reviewer 2 (Sam Lambert) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene Candidate_DNA-Binding: sequence-specific_Transactivation_PMIDS:12549979;15831758
Annotated as a GO transcription factor: Yes
Gene: TFCP2 (ENSG00000135457)
DNA-binding domain: Grainyhead
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Matt Weirauch) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:15232220
Annotated as a GO transcription factor: Yes
Gene: TFCP2L1 (ENSG00000115112)
DNA-binding domain: Grainyhead
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Matt Weirauch) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: UBP1 (ENSG00000153560)
DNA-binding domain: Grainyhead
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:15988015
Annotated as a GO transcription factor: Yes
Gene: GTF2I (ENSG00000263001)
DNA-binding domain: GTF2I-like
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: In vivo/Misc source
Notes: Only known motifs are from Transfac or HocoMoco - origin is uncertain
Comments: (PMID: 18326499) shows through SELEX and EMSA that this family binds DNA specifically. Transfac motifs are dubious.
MTW notes: PMID 18326499 shows through SELEX and EMSA that this family binds DNA specifically
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 notes: needs to be checked; but logo could be indirect
Reviewer 2 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: Probably non-specific DNA binding protein that participates in pre-initiation complexes. Motifs are likely in vivo signals and it is hard to define how much of the specificity is from this protein
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8662630;17052463
Annotated as a GO transcription factor: Yes
Gene: GTF2IRD1 (ENSG00000006704)
DNA-binding domain: GTF2I-like
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: In vivo/Misc source
Notes: Only known motifs are from Transfac or HocoMoco - origin is uncertain
Comments: (PMID: 18326499) shows through SELEX and EMSA that this family binds DNA specifically. Transfac motifs are dubious. V$BEN_02 motif has partial similarity to a shift-experiment sequence (PMID:14645227), which shows DNA-binding and evidence of transcriptional regulation by knockdown experiments
MTW notes: PMID 18326499 shows through SELEX and EMSA that this family binds DNA specifically
Disagreement on assessment: Disagree
Reviewer 1 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Third transfac-model is for a PITX-like homeodomain
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 comment: Direct motifs appear to be dubious; and match HLH and Homeodomain motifs. V$BEN_02 motif has partial similarity to a shift-experiment sequence (PMID:14645227); that shows DNA-binding and evidence of transcriptional regulation by knockdown experiments
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:14645227
Annotated as a GO transcription factor: Yes
Gene: GTF2IRD2 (ENSG00000196275)
DNA-binding domain: GTF2I-like
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Comments: (PMID: 18326499) shows through SELEX and EMSA that this family binds DNA specifically.
MTW notes: PMID 18326499 shows through SELEX and EMSA that this family binds DNA specifically
Disagreement on binding: Disagree
Reviewer 1 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Paralog GTF2IRD binds PITX-like target sequence AYNRGATTAWM based on PMID: 17346708. Probably non-specific DNA binding protein that participates in pre-initiation complexes. It is hard to define how much of the specificity  revealed by in vivo data i
Reviewer 2 (Sam Lambert) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: GTF2IRD2B (ENSG00000174428)
DNA-binding domain: GTF2I-like
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Comments: (PMID: 18326499) shows through SELEX and EMSA that this family binds DNA specifically.
MTW notes: PMID 18326499 shows through SELEX and EMSA that this family binds DNA specifically
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: There is no direct evidence for sequence specific DNA binding activity. Transfac has motifs for orthologs GTF2I and GTF2IRD1 but they are fishy; one of the sites for the latter is a PITX-like homeodomain target site GGATTA.
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 notes: YES
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0
Annotated as a GO transcription factor: Yes
Gene: AC105001.2 (ENSG00000258724)
DNA-binding domain: HMG/Sox
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Unlikely to be sequence specific TF - it has a deletion inside the SOX-domain removing several residues that contact DNA based on the structure of paralog SOX17.
AJ notes: Unlikely to be sequence specific TF, it actually has a deletion inside the SOX-domain removing several residues that contact DNA based on the structure of paralog SOX17
Reviewer 1 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Protein has same DBD as SOX7
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: BBX (ENSG00000114439)
DNA-binding domain: HMG/Sox
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
AJ notes: "Likely to be sequence specific TF", "1 Monomer or homomultimer" Based on alignment CIC, BBX and HBP1 are more similar to the SOX and TCF7 groups rather than non sequence specific HMGs
Reviewer 1 (Matt Weirauch) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: CCDC124 (ENSG00000007080)
DNA-binding domain: HMG/Sox
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: Based on the alignment, it lacks a proper HMG domain. Evidence it binds RNA (PMID: 22658674).
Committee notes: Based on HMG/Sox alignment
AJ notes: Based on alignment It really does not have a proper HMG domain, the aminoacid sequence is truncated
Reviewer 1 (Laura Campitelli) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Binds RNA [PMID: 22658674]
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: CHD3 (ENSG00000170004)
DNA-binding domain: HMG/Sox
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Notes: Has a putative AT-hook
Comments: No evidence for sequence-specific DNA-binding in the literature; and contains only a partial match to an HMG box with no similarity to DBDs of other CHD family proteins 
Committee notes: Based on HMG/Sox alignment
AJ notes: Based on alignment It really does not have a proper HMG domain, the aminoacid sequence is truncated
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: No evidence for sequence-specific DNA-binding in the literature; and contains only a partial match to an HMG box with no similarity to DBDs of other CHD family proteins 
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: Component of the NuRD complex
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: CHD4 (ENSG00000111642)
DNA-binding domain: HMG/Sox
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: CHD4 is likely not a sequence-specific DNA-binding protein despite having a partial match to an HMG box. This protein binds to the DNA backbone, but binds poly(ADP-ribose) with higher affinity (PMID: 26565020).
Committee notes: Based on HMG/Sox alignment
AJ notes: Based on alignment It really does not have a proper HMG domain, the aminoacid sequence is truncated
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: CHD4 is likely not a sequence-specific DNA-binding protein despite having a partial match to an HMG box. This protein binds to the DNA backbone; but binds poly(ADP-ribose) with higher affinity (PMID: 26565020) 
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: PMID: 26565020 
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: CIC (ENSG00000079432)
DNA-binding domain: HMG/Sox
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: 100%ID - in vitro
Committee notes: Based on HMG/Sox alignment
AJ notes: Based on alignment CIC, BBX and HBP1 are more similar to the SOX and TCF7 groups rather than non sequence specific HMGs
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:16717057
Annotated as a GO transcription factor: No
Gene: HBP1 (ENSG00000105856)
DNA-binding domain: HMG/Sox
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: 100%ID - in vitro
Committee notes: Based on HMG/Sox alignment
AJ notes: "Likely to be sequence specific TF", "1 Monomer or homomultimer" Based on alignment CIC, BBX and HBP1 are more similar to the SOX and TCF7 groups rather than non sequence specific HMGs
Disagreement on assessment: Disagree
Reviewer 1 (Tim Hughes) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Seems more similar to Sox than HMG proteins.  
Reviewer 1 notes: check HMG sequence similarity tree and find where Transfac and Hocomoco got the sequences from.  The Hocomoco web site says it's from aligning only five sequences.
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 comment: Transfac motif looks similar to mouse ortholog's PBM motif
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: HMG20A (ENSG00000140382)
DNA-binding domain: HMG/Sox
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Comments: Similar to HMG20B, which has an inferred motif from mouse.
Committee notes: Based on HMG/Sox alignment
AJ notes: HMG domain lacks many of the residues that contact DNA in SOX17 structure
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Need a systematic way to decide on HMG boxes that we have not tested before
Reviewer 1 notes: yes - not sure how to deal with untested HMGs
Reviewer 2 (Sam Lambert) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: HMG box presence is the only evidence of TF activity. Studies showing HMG20A and its paralog HMG20B to be alternative members of the LSD1-CoREST complex (PMIDs:1121522109); and a recruiter of the MLL complex (PMID:16227968) suggest that it could have
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: HMG20B (ENSG00000064961)
DNA-binding domain: HMG/Sox
Is a transcription factor: Yes
TF assessment: Inferred motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Committee notes: Based on HMG/Sox alignment
AJ notes: HMG domain lacks many of the residues that contact DNA in SOX17 structure
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 notes: test
Reviewer 2 (Matt Weirauch) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: HMGB1 (ENSG00000189403)
DNA-binding domain: HMG/Sox
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: In the alignment, it clusters with other HMG proteins that have not yielded motifs. Evidence exists showing HMGB1/2 are non-sequence-specific binding proteins (PMID: 11497996).
Committee notes: Based on HMG/Sox alignment
AJ notes: "Unlikely to be sequence specific TF", "3 Low specificity DNA-binding protein". In the alignment it clusters together with other HMG proteins that have not yielded motifs 
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 (Sam Lambert) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: Although the structure is with cisplatin-modified bases/crosslinking it appears that HMGB1 makes specific contacts with the bases (PDB:1CKT). HMGB1 has also been shown to regulate transcription (PMID:19223331)
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
PDB structure: 1CKT
Gene: HMGB2 (ENSG00000164104)
DNA-binding domain: HMG/Sox
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: In the alignment, it clusters with other HMG proteins that have not yielded motifs. Evidence exists showing HMGB1/2 are non-sequence-specific binding proteins (PMID: 11497996). HMGB2 is well-known to facilitate DNA-bending and interact with sequence-specific TFs and transcriptional co-factors.
Committee notes: Based on HMG/Sox alignment
AJ notes: "Unlikely to be sequence specific TF", "3 Low specificity DNA-binding protein". In the alignment it clusters together with other HMG proteins that have not yielded motifs 
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: HMGB2 is well-known to facilitate DNA-bending and interact with multiple other sequence-specific TFs and transcriptional co-factors. It's binding can influence other TFs and thus regulate transcription. The specificity for which DNA appears to be wea
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: non-sequence-specific_Non-specific DNA_PMIDS:9888798;11748232;12517784
Annotated as a GO transcription factor: Yes
Gene: HMGB3 (ENSG00000029993)
DNA-binding domain: HMG/Sox
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: Similar to HMGB1/2, which bind DNA with low specificity
Committee notes: Based on HMG/Sox alignment
AJ notes: "Unlikely to be sequence specific TF", "3 Low specificity DNA-binding protein". In the alignment it clusters together with other HMG proteins that have not yielded motifs 
Reviewer 1 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Evidence showing HMGB1/2 are non-sequenc-specific binding proteins [PMID: 11497996]. I'd like to classify HMGB3 as non-sequence-specific bind protien based on the high similarity of protein sequence to HMGB1/2.
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: PMID: 8159753; PMID: 17081121
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: HMGB4 (ENSG00000176256)
DNA-binding domain: HMG/Sox
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: Similar to HMGB1/2, which bind DNA with low specificity. Yet, it can also bind with 4.35nM affinity to DNA containing an intra-strand crosslink made by cis-platin (PMID: 22901013).
Committee notes: Based on HMG/Sox alignment
AJ notes: "Unlikely to be sequence specific TF", "3 Low specificity DNA-binding protein". In the alignment it clusters together with other HMG proteins that have not yielded motifs 
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Is expressed in neurons and developing sperm and is associated tightly with chromatin PMID: 27608812. Binds with 4.35nM affinity to DNA with intra-strand crosslink made with Cis-platin PMID: 22901013
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: PMID: 22901013 says it has strong affinity for cisplatin modified DNA.
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No