Jerryhuang001/TF_network huggingface dataset:
Gene: ANXA4 (ENSG00000196975)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: AP5Z1 (ENSG00000242802)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: May have helicase activity and play a role in DNA repair (PMID: 20613862) 
Committee notes: PMID: 20613862 propose that it may have helicase activity and play a role in DNA repair
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 notes: where does the orthologous evidence come from?
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: PMID: 20613862 propose that it may have helicase activity and play a role in DNA repair
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: APBB3 (ENSG00000113108)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; Other_PMIDS:10199399;15180993
Annotated as a GO transcription factor: No
Gene: APEX1 (ENSG00000100823)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: The structure (PDB:1DEW) is with abasic DNA - the protein is a base excision repair enzyme that cleaves off abasic bases
Reviewer 1 (Tim Hughes) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Nuclease involved in base repair
Reviewer 2 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: The structure PDB:1DEW is with abasic DNA; the protein is a base excision repair enzyme that cleaves off abasic bases
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Other_PMIDS:1380454;15084519;15674341
Annotated as a GO transcription factor: No
PDB structure: 1DEW
Gene: APOBEC3A (ENSG00000262156)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Binds ssDNA (PDB: 5KEG)
TRH notes: apolipoprotein B mRNA editing enzyme catalytic subunit 3A 
AJ notes: 5KEG
Reviewer 1 (Arttu Jolma) assessment: ssDNA/RNA binding; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Binds single stranded DNA in the structure; PDB: 5KEG
Reviewer 2 (Sam Lambert) assessment: ssDNA/RNA binding; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Binds ssDNA (PDB:5KEG)
TFclass considers it a TF: No
Gene: APOBEC3B (ENSG00000179750)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Binds ssDNA (PDB: 5TD5)
TRH notes: apolipoprotein B mRNA editing enzyme catalytic subunit 3B 
AJ notes: 5TD5
Reviewer 1 (Arttu Jolma) assessment: ssDNA/RNA binding; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Binds single stranded DNA in the structure; PDB: 5TD5
Reviewer 2 (Sam Lambert) assessment: ssDNA/RNA binding; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Binds ssDNA (PDB:5TD5)
TFclass considers it a TF: No
Gene: APOBEC3G (ENSG00000239713)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Restriction factor of HIV-1 that binds ssDNA (PDB: 5K83)
TRH notes: apolipoprotein B mRNA editing enzyme catalytic subunit 3G 
AJ notes: 5K83
Reviewer 1 (Arttu Jolma) assessment: ssDNA/RNA binding; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Binds single stranded DNA in the structure; PDB: 5K83
Reviewer 2 (Sam Lambert) assessment: ssDNA/RNA binding; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Restriction factor of HIV-1 that binds ssDNA (PDB:5K83)
TFclass considers it a TF: No
Gene: APTX (ENSG00000137074)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Binds and fixes DNA-RNA hybrids/ APTX efficiently repairs adenylated RNA-DNA and acts in the RNA-DNA damage response (PMID: 24362567)
Disagreement on binding: Disagree
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Binds and fixes DNA-RNA hybrids APTX efficiently repairs adenylated RNA-DNA; and acting in an RNA-DNA damage response (RDDR) pmid: 24362567
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
PDB structure: 4NDF
Gene: ARHGAP35 (ENSG00000160007)
DNA-binding domain: Unknown
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Comments: Binds DNA specifically based on EMSA and nuclease protection assay data (PMID: 1894621), despite lacking any clear DBDs.
Reviewer 1 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Binds PMID: 1894621 based on EMSA and nuclease protection assay data; however it does not have any clear DBDs.
Reviewer 1 notes: Current HNGC symbol is ARHGAP35
Reviewer 2 (Matt Weirauch) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: Could be a legit "non-traditional" TF: PMID 1894621
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:1894621
Annotated as a GO transcription factor: Yes
Gene: ARHGEF2 (ENSG00000116584)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: ARHGEF5 (ENSG00000050327)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: GO annotation provides no evidence of DNA-binding activity (PMID: 15601624)
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: GO annotation has no evidence of DNA-binding activity (PMID:15601624)
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: ARRB1 (ENSG00000137486)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: ChIP data available, but unclear if it can bind to DNA directly (PMID: 16325578)
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: There was ChIP data for it; but no sure if it could bind to DNA directly. [PMID: 16325578]
Reviewer 2 notes: yes
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: ARRB2 (ENSG00000141480)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: If ARRB1 is a potential TFs; why not ARRB2?
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Didn't find any DNA binding activity
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: ASCC1 (ENSG00000138303)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Protein is a coactivator that is reported to bind to SRF, NFKB1, and JUN (PMID: 12077347)
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Protein is a coactivator that is reported to bind to SRF; NFKB1 and JUN PMID: 12077347
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: ASCC1 is a transcriptional co-factor 
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:10454579
Annotated as a GO transcription factor: No
Gene: ATF7IP (ENSG00000171681)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Murine homolog involved in H4K9 trimethylation by SETDB1 (PMID: 14536086)
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Murine homolog involved in H4K9 trimethylation by SETDB1 [PMID: 14536086]
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:10777215;14536086
Annotated as a GO transcription factor: No
Gene: ATM (ENSG00000149311)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Kinase protein that binds to and activates certain TFs
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Kinase protein that binds to and activates certain TFs
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation; DNA Binding_PMIDS:12496286;16461339;16644862
Annotated as a GO transcription factor: No
Gene: ATR (ENSG00000175054)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene Candidate_Transcription Regulatory Activity: heterochromatin interaction/binding; Transcription Factor Binding: tf co-factor binding; Single stranded RNA/DNA binding_Other_PMIDS:10545197;12011
Annotated as a GO transcription factor: No
Gene: ATRX (ENSG00000085224)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: ATRX does not contain any canonical sequence-specific DBDs but it does contain a non-specific DNA binding helicase that allows it to bind repeat sequences (PMID:21029860) and telomeres (PMID:20651253). ATRX is involved in multiple processes (transcription, replication), and is associated with multiple complexes (Swi/Snf, histone chaperones, and repressive complexes including TRIM 28 (PMID:27029610)), and as such does affect transcription. Given the lack of sequence-specific binding it is unlikely to be a TF, however.
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Protein is a component of a nucleosome remodeling complex and contact the DNA with a helicase domain PMID:25865896
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: ATRX does not contain any canonical sequence-specific DBDs but does contain non-specific DNA binding helicase that allows it to bind repeat sequences (PMID:21029860) and telomeres (PMID:20651253). ATRX is involved in multiple processes (transcription, replication), and associated with multiple complexes (Swi/Snf, histone chaperones, and repressive complexes including TRIM 28 (PMID:27029610) and as such does affect transcription. Given the lack of sequence-specific binding it is unlikely to be a TF
CisBP considers it a TF: #N/A
TFclass considers it a TF: #N/A
TF-CAT classification: #N/A
Annotated as a GO transcription factor: #N/A
PDB structure: #N/A
Gene: ATXN7 (ENSG00000163635)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: ATXN7 SCA7 domain facilitates interactions with histone dimers (PMID: 20634802)
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: ATXN7 SCA7 domain facilitates interactions with histone dimers (PMID:20634802)
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: BAG1 (ENSG00000107262)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Antiapoptotic BCL-protein
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Antiapoptotic BCL-protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:9642262
Annotated as a GO transcription factor: No
Gene: BANF1 (ENSG00000175334)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: No motif
Comments: Binds DNA in the crystal structure, contacting only the backbone from the side of the minor groove (PDB: 2BZF)
TRH notes: barrier to autointegration factor 1 
AJ notes: 2BZF
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Binds DNA in the crystal structure, contacts only backbone from the side of the minor groove; PDB: 2BZF
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: Contains helix-hairpin-helix (HhH) motif known to non-specifically bind dsDNA
TFclass considers it a TF: No
Gene: BANP (ENSG00000172530)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Notes: Only known motifs are from Transfac or HocoMoco - origin is uncertain
Comments: BANP has no DBD and is known to bind other TFs; likely that the Transfac motif is from one of its binding partners 
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Binds some kind of ridiculous 170bp MAR-element based on EMSA with fusion protein PMID: 10950932. Protein does not have any clear DBDs while on the other hand the Transfac model isn't any of the usual suspects
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: BANP has no DBD and is known to bind other TFs; likely that the Transfac motif is from one of its binding partners 
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: BCL10 (ENSG00000142867)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Apoptosis associated protein that operates upstream on a cascade that includes NFKB
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Apoptosis associated protein that operates upstream on a cascade that has NFKB on it
Reviewer 2 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: BCL3 (ENSG00000069399)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Notes: Only known motifs are from Transfac or HocoMoco - origin is uncertain
Comments: No DBD - instead, this is a known cofactor of NF-kappaB.  The Transfac motif is the NFKB1 motif.  GO cites only electronic annotation and needs to be fixed.
Disagreement on assessment: Disagree
Reviewer 1 (Tim Hughes) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: No DBD - instead; this is a known cofactor of NF-kappaB.  The Transfac motif is the NFKB1 motif.  GO cites only electronic annotation and needs to be fixed.
Reviewer 2 (Arttu Jolma) assessment: Has known motif; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Suspect motif; this protein binds NFKB1 and is tethered to DNA through it PMID: 8453667; the motif is similar to NFKB motifs and thus it makes sense. Protein could in theory change the specificity of NFKB through allosteric effect 
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding_TF PPI_PMIDS:1501714
Annotated as a GO transcription factor: No
Gene: BCLAF1 (ENSG00000029363)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 3 Low specificity DNA-binding protein
Motif status: In vivo/Misc source
Notes: Only known motifs are from Transfac or HocoMoco - origin is uncertain
Comments: No DBD. Only weak evidence is available for indirect binding (PMID: 10330179). Suspect motif - it is a clear ETS-site. (PMID: 10330179) shows that the protein binds DNA in filter binding assay, but not that it is sequence specific.
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 comment: Suspect motif - it is a clear ETS-site. The article the other reviewer had found PMID: 10330179 shows that the protein binds DNA in filter binding assay; but not that it is sequence specific
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: PMID: 10330179 says it has DNA mediated transcriptional repressor activity and If we dont trust the motif then I put it as likely TF.
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: BCOR (ENSG00000183337)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Transcriptional co-repressor that associates with BCL6 (PMID: 10898795)
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Transcriptional co-repressor that associates with BCL6 PMID: 10898795
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Lacks a DBD; and literature evidence for DNA-binding 
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene Candidate_Transcription Factor Binding: tf co-factor binding_Co-activation; TF PPI_PMIDS:10898795;10898795
Annotated as a GO transcription factor: No
Gene: BDP1 (ENSG00000145734)
DNA-binding domain: Unknown
Is a transcription factor: No
TF assessment: Unlikely to be sequence specific TF
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
MTW notes: Sam:  "Prosite identifies a low-confidence Myb-like domain (e.g. can?t decide between Myb and SANT) so it?s probably not a TF"
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 1 notes: Homeo-like and SANT domains; check amino-acids required for binding
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: I didnt find any DNA binding property.
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: TF Gene_Basal Transcription Factor_TF PPI_PMIDS:11971960;12930823;14527415;15469824
Annotated as a GO transcription factor: No