Jerryhuang001/TF_network huggingface dataset:
Gene: RNF113B (ENSG00000139797)
DNA-binding domain: CCCH ZF
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Possibly a RNA-binding protein based on presence of znf CCCH domains
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Likely involved in ubiquitination based on presence of zf-C3HC4 domains
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: TOE1 (ENSG00000132773)
DNA-binding domain: CCCH ZF
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Tim Hughes) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Included because Vasquerizas 2009 gives it a "b" (ortholog of a known TF).  I don't see what that ortholog is; though.  CCCH is usually an RNA-binding domain; not a DNA binding domain.
Reviewer 2 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: RBP?
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: TRMT1 (ENSG00000104907)
DNA-binding domain: CCCH ZF
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Tim Hughes) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: tRNA methyltransferase - has CCCH domains; indicative of RNA binding - included only because Vasquerizas 2009 included it with an "x".
Reviewer 2 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: UNK (ENSG00000132478)
DNA-binding domain: CCCH ZF
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: RBP?
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: CCCH ZFs are usually RNA-binding proteins 
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: UNKL (ENSG00000059145)
DNA-binding domain: CCCH ZF
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: DNA-binding CCCH ZFs are truncated and not present in most isoforms. C3HC4 ZFs that are present are not known to bind DNA
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ZC3H10 (ENSG00000135482)
DNA-binding domain: CCCH ZF
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Tim Hughes) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Looks like an RNA binding protein to me.  CisBP includes it because it has a bZIP domain; but it doesn't show up on pfam or SMART; and I don't see any basic residues.
Reviewer 2 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ZC3H11A (ENSG00000058673)
DNA-binding domain: CCCH ZF
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Possible RNA-binding protein
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ZC3H12A (ENSG00000163874)
DNA-binding domain: CCCH ZF
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
MTW notes: PMID 18364357 does not show direct DNA binding
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 
Reviewer 2 comment: PMID: 18364357 says MCPIP binding was DNA sequence-specific. PMID: 23355615 says it also bind RNA(viral)
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: ZC3H13 (ENSG00000123200)
DNA-binding domain: CCCH ZF
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Disagreement on assessment: Disagree
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: we got motifs for two of CCCH protein
Reviewer 2 notes: yes
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ZC3H14 (ENSG00000100722)
DNA-binding domain: CCCH ZF
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: Binds UUUNUUU RNA-sequence based on Ray et al 2013 (PMID: 23846655).
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: RBP?
Reviewer 2 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Binds UUUNUUU RNA-sequence based on Ray et al 2013 pmid:23846655 
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ZC3H15 (ENSG00000065548)
DNA-binding domain: CCCH ZF
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ZC3H18 (ENSG00000158545)
DNA-binding domain: CCCH ZF
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: RBP?
Reviewer 2 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: looks like an RBP
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ZC3H3 (ENSG00000014164)
DNA-binding domain: CCCH ZF
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Disagreement on binding: Disagree
Reviewer 1 (Tim Hughes) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: From GeneCards:  "Required for the export of polyadenylated mRNAs from the nucleus (PubMed:19364924). Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 3 Low specificity DNA-binding protein
Reviewer 2 comment: Evidence showing it could bind to single-stranded DNA; but not to double-stranded DNA
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ZC3H4 (ENSG00000130749)
DNA-binding domain: CCCH ZF
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Notes: Has a putative AT-hook
Reviewer 1 (Matt Weirauch) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ZC3H6 (ENSG00000188177)
DNA-binding domain: CCCH ZF
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Protein is likely a RBP
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ZC3H7A (ENSG00000122299)
DNA-binding domain: CCCH ZF
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Based on domains it is likely to be a RBP
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ZC3H7B (ENSG00000100403)
DNA-binding domain: CCCH ZF
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Based on the domain it is likely to be an RNA-binding protein
Reviewer 2 (Yimeng Yin) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ZC3H8 (ENSG00000144161)
DNA-binding domain: CCCH ZF
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Comments: Mouse ortholog can bind DNA specifically, based on EMSA (PMID: 12077251).
Reviewer 1 (Matt Weirauch) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: PMID 12077251 shows it can bind DNA specifically
Reviewer 2 (Laura Campitelli) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: Mouse ortholog is a sequence-specific transcription factor [PMID: 12077251]
CisBP considers it a TF: No
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Other_PMIDS:12077251
Annotated as a GO transcription factor: Yes
Gene: ZC3HAV1 (ENSG00000105939)
DNA-binding domain: CCCH ZF
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: RNA-binding protein (PMID: 22658674; PMID: 22681889).
Reviewer 1 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: RNA-binding protein [PMID: 22658674] [PMID: 22681889]
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ZFP36 (ENSG00000128016)
DNA-binding domain: CCCH ZF
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: RNA binding protein (PMID: 10330172).
Disagreement on binding: Disagree
Reviewer 1 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Likely an RNA-binding protein 
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 
Reviewer 2 comment: PMID: 10330172 indicates its RNA binding property.
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0
Annotated as a GO transcription factor: No
Gene: ZFP36L1 (ENSG00000185650)
DNA-binding domain: CCCH ZF
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: RNA-binding protein (PMID: 27102483; PMID: 17013884).
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Protein is a RBP PMID: 21278925
Reviewer 2 (Sam Lambert) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: GO annotation has no evidence for DNA-binding activity; and has multiple citations for it's role as an RNA-binding protein (PMID:27102483;17013884)
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: Probably Not a TF - No evidence that it is a TF___PMIDS:0
Annotated as a GO transcription factor: Yes
Gene: ZFP36L2 (ENSG00000152518)
DNA-binding domain: CCCH ZF
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Comments: RNA-binding protein (PMID: 20506496).
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: RBP?
Reviewer 2 (Pratyush Das) assessment: Unlikely to be sequence specific TF; binding: 
Reviewer 2 comment: PMID 20506496 suggests it binds RNA
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: ZGPAT (ENSG00000197114)
DNA-binding domain: CCCH ZF
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Comments: Binds RRRGGAGGAGA based on SELEX and EMSA (PMID: 19644445).
Reviewer 1 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Binds RRRGGAGGAGA based on SELEX and EMSA performed in PMID: 19644445
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: No
TFclass considers it a TF: Yes
TF-CAT classification: No
Annotated as a GO transcription factor: Yes
Gene: ZMAT5 (ENSG00000100319)
DNA-binding domain: CCCH ZF
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Tim Hughes) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: component of U11/U12 Small Nuclear Ribonucleoprotein.  If anything; it's an RNA binding protein; since it has a CCCH domain.  Included only because Vasquerizas 2009 listed it with an "x".
Reviewer 2 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: RBP?
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: ZRSR1 (ENSG00000212643)
DNA-binding domain: CCCH ZF
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: Protein is likely a RNA binding protein based on presence of RRM and znf CCCH domains
Reviewer 2 (Laura Campitelli) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Binds RNA; involved in splicing (UniProt Q15695 - citation unclear)
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: Not a TF - Evidence that it is not a TF__Other_PMIDS:14673161
Annotated as a GO transcription factor: No
Gene: ZRSR2 (ENSG00000169249)
DNA-binding domain: CCCH ZF
Is a transcription factor: No
TF assessment: ssDNA/RNA binding
Binding mode: 4 Not a DNA binding protein
Motif status: No motif
Reviewer 1 (Jussi Taipale) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 1 comment: RBP?
Reviewer 2 (Arttu Jolma) assessment: Unlikely to be sequence specific TF; binding: 4 Not a DNA binding protein
Reviewer 2 comment: Protein is a RBP
CisBP considers it a TF: No
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: CENPB (ENSG00000125817)
DNA-binding domain: CENPB
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Matt Weirauch) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
PDB structure: 1HLV
Gene: CENPBD1 (ENSG00000177946)
DNA-binding domain: CENPB
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Motif is also similar to a half of the CENPB binding site
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: JRK (ENSG00000234616)
DNA-binding domain: CENPB
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Reviewer 1 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: see TIGD4 for evidence
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: JRKL (ENSG00000183340)
DNA-binding domain: CENPB
Is a transcription factor: Yes
TF assessment: Inferred motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Has a potential DBD related to CENPB
Reviewer 2 (Laura Campitelli) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: TIGD1 (ENSG00000221944)
DNA-binding domain: CENPB
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: TIGD2 (ENSG00000180346)
DNA-binding domain: CENPB
Is a transcription factor: Yes
TF assessment: Inferred motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Laura Campitelli) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: see TIGD4 for evidence
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: TIGD3 (ENSG00000173825)
DNA-binding domain: CENPB
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Reviewer 1 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Has similar DBD as CENPB; so it could be also a DBD
Reviewer 2 (Laura Campitelli) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: TIGD4 (ENSG00000169989)
DNA-binding domain: CENPB
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Comments: Evidence showing that the two HTH domains in the protein together bind specifically to a 17-base-pair sequence; the CENP-B box; which occurs in alpha-satellite DNA in human centromeres (PMID: 16183641).
Reviewer 1 (Yimeng Yin) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Evidence showing that the two HTH domains in the protein together bind specifically to a 17-base-pair sequence; the CENP-B box; which occurs in alpha-satellite DNA in human centromeres [PMID: 16183641].
Reviewer 2 (Pratyush Das) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No
Gene: TIGD5 (ENSG00000179886)
DNA-binding domain: CENPB
Is a transcription factor: Yes
TF assessment: Likely to be sequence specific TF
Binding mode: 1 Monomer or homomultimer
Motif status: No motif
Reviewer 1 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 1 notes: check amino-acids required for binding
Reviewer 2 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
Reviewer 2 comment: Related CENPB that binds DNA in a specific manner
CisBP considers it a TF: Yes
TFclass considers it a TF: No
TF-CAT classification: No
Annotated as a GO transcription factor: No