Jerryhuang001/TF_network huggingface dataset:
Gene: NR1D2 (ENSG00000174738)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Matt Weirauch) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7838156
Annotated as a GO transcription factor: No
Gene: NR1H2 (ENSG00000131408)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 2 Obligate heteromer
Motif status: In vivo/Misc source
Notes: Only known motifs are from Transfac or HocoMoco - origin is uncertain
Comments: Likely an obligate heteromer (PMID: 7935418; PMID: 7892230; PMID: 7744246)
Disagreement on assessment: Disagree
Reviewer 1 (Matt Weirauch) assessment: Likely to be sequence specific TF; binding: 2 Obligate heteromer
Reviewer 1 comment: Seems to be an obligate heteromer: PMID 7935418; 7892230; 7744246
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 2 Obligate heteromer
Reviewer 2 comment: Can't tell whether Transfac motif is a homodimer; or heterodimer which is supported by a structure (PBD: 4NQA)
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:16007255;17218271
Annotated as a GO transcription factor: Yes
PDB structure: 4NQA
Gene: NR1H3 (ENSG00000025434)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Inferred motif
Binding mode: 2 Obligate heteromer
Motif status: In vivo/Misc source
Comments: Binds as an obligate heterodimer with RXR-proteins. (PDB: 2ACL) is a crystal structure of the two proteins without DNA
TRH notes: Obligate heterodimer
Reviewer 1 (Jussi Taipale) assessment: Likely to be sequence specific TF; binding: 2 Obligate heteromer
Reviewer 1 notes: clone wrong or obligate heterodimer; check also residues
Reviewer 2 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 2 Obligate heteromer
Reviewer 2 comment: Binds as an obligate heterodimer with RXR-proteins. PDB:2ACL is a crystal structure of the two proteins without DNA
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9013544
Annotated as a GO transcription factor: Yes
Gene: NR1H4 (ENSG00000012504)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Comments: Also binds DNA as heterodimer with RXRA (PMID: 11870371)
Disagreement on binding: Disagree
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 2 Obligate heteromer
Reviewer 1 comment: Based on PMID: 11870371 it binds DNA as heterodimer with RXRA
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific; Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:11533040
Annotated as a GO transcription factor: Yes
Gene: NR1I2 (ENSG00000144852)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Matt Weirauch) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:11114890
Annotated as a GO transcription factor: No
Gene: NR1I3 (ENSG00000143257)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8114692;12511605
Annotated as a GO transcription factor: Yes
Gene: NR2C1 (ENSG00000120798)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12849971
Annotated as a GO transcription factor: No
Gene: NR2C2 (ENSG00000177463)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Encode motifs are not binding sites for this TF but clear ETS class II target sites 
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:9006963
Annotated as a GO transcription factor: Yes
Gene: NR2E1 (ENSG00000112333)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:8047143;11073974
Annotated as a GO transcription factor: No
Gene: NR2E3 (ENSG00000278570)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 2 Obligate heteromer
Reviewer 1 notes: most likely obligate heterodimer
Reviewer 2 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding_Co-activation_PMIDS:15689355
Annotated as a GO transcription factor: Yes
Gene: NR2F1 (ENSG00000175745)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:2739739;17009409
Annotated as a GO transcription factor: Yes
Gene: NR2F2 (ENSG00000185551)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: 100%ID - in vitro
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:8622679
Annotated as a GO transcription factor: Yes
Gene: NR2F6 (ENSG00000160113)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:12690040
Annotated as a GO transcription factor: Yes
Gene: NR3C1 (ENSG00000113580)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:16728402;67253380;15563547
Annotated as a GO transcription factor: Yes
PDB structure: 1GLU
Gene: NR3C2 (ENSG00000151623)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Matt Weirauch) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:3037703;8389140
Annotated as a GO transcription factor: No
PDB structure: 4TNT
Gene: NR4A1 (ENSG00000123358)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:16237153
Annotated as a GO transcription factor: Yes
PDB structure: 1CIT
Gene: NR4A2 (ENSG00000153234)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Disagreement on assessment: Disagree
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Arttu Jolma) assessment: Likely to be sequence specific TF; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_Co-activation; DNA Binding; Transactivation_PMIDS:12122012;15485875
Annotated as a GO transcription factor: Yes
Gene: NR4A3 (ENSG00000119508)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: In vivo/Misc source
Notes: Only known motifs are from Transfac or HocoMoco - origin is uncertain
Reviewer 1 (Tim Hughes) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 notes: I think all TFs in Transfac and Hocomoco - but with no other motif source - need to be examined manually and the source data tracked down.
Reviewer 2 (Matt Weirauch) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:10875239
Annotated as a GO transcription factor: Yes
Gene: NR5A1 (ENSG00000136931)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Matt Weirauch) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_Other_PMIDS:8463279;10913126
Annotated as a GO transcription factor: Yes
PDB structure: 2FF0
Gene: NR5A2 (ENSG00000116833)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Matt Weirauch) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:12456679;15014077
Annotated as a GO transcription factor: Yes
PDB structure: 2A66
Gene: NR6A1 (ENSG00000148200)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:9099702;15236322
Annotated as a GO transcription factor: Yes
Gene: PGR (ENSG00000082175)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Matt Weirauch) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:5579944;12114521
Annotated as a GO transcription factor: Yes
PDB structure: 2C7A
Gene: PPARA (ENSG00000186951)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: In vivo/Misc source
Notes: Only known motifs are from Transfac or HocoMoco - origin is uncertain
Reviewer 1 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1537328;8123021;8386511;12847522;9748239
Annotated as a GO transcription factor: Yes
Gene: PPARD (ENSG00000112033)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Matt Weirauch) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_Other_PMIDS:11923467
Annotated as a GO transcription factor: Yes
Gene: PPARG (ENSG00000132170)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: 100%ID - in vitro
Comments: Also heterodimerizes.
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 comment: also heterodimerizes
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_Transactivation_PMIDS:14744933;15681609
Annotated as a GO transcription factor: Yes
PDB structure: 3DZU
Gene: RARA (ENSG00000131759)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:1312934
Annotated as a GO transcription factor: Yes
PDB structure: 1DSZ
Gene: RARB (ENSG00000077092)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Tim Hughes) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:2153268
Annotated as a GO transcription factor: No
Gene: RARG (ENSG00000172819)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:2544807;15327771
Annotated as a GO transcription factor: Yes
Gene: RORA (ENSG00000069667)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding_PMIDS:7926749;7926749;15941850;15821743;7926749;12467577
Annotated as a GO transcription factor: Yes
Gene: RORB (ENSG00000198963)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Laura Campitelli) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:7935491
Annotated as a GO transcription factor: Yes
Gene: RORC (ENSG00000143365)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0
Annotated as a GO transcription factor: Yes
Gene: RXRA (ENSG00000186350)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Transfac motifs are not correct
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_Transcription Factor Binding: tf co-factor binding; DNA-Binding: sequence-specific_DNA Binding; TF PPI_PMIDS:7838715;15544927
Annotated as a GO transcription factor: Yes
PDB structure: 1BY4
Gene: RXRB (ENSG00000204231)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Comments: Has been shown to bind both as a homodimer and with several nuclear receptor homodimerization partners
Reviewer 1 (Arttu Jolma) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 1 comment: Has been shown to bind both as a homodimer and with several nuclear receptor homodimerization partners
Reviewer 2 (Pratyush Das) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene Candidate_DNA-Binding: sequence-specific_DNA Binding_PMIDS:2554307;10393558
Annotated as a GO transcription factor: No
Gene: RXRG (ENSG00000143171)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Comments: Usually binds in vivo as a heterodimer, but can bind as a homodimer in vitro 
AJ notes: "Has known motif","1 Monomer or homomultimer" Has many independent HT-SELEX results. All RXR-proteins make heterodimers with other nuclear receptors but appear also to bind as homodimers
Disagreement on binding: Disagree
Reviewer 1 (Jussi Taipale) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 2 Obligate heteromer
Reviewer 2 comment: Usually binds as a heterodimer; but can be seen as a homodimer in vitro 
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: Indeterminate - There is no evidence for or against this genes role as a TF___PMIDS:0
Annotated as a GO transcription factor: Yes
Gene: THRA (ENSG00000126351)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Comments: Likely binds as a heterodimer too 
Reviewer 1 (Tim Hughes) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 comment: Likely binds as a heterodimer too 
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_Co-activation; DNA Binding_PMIDS:8559662;11773435
Annotated as a GO transcription factor: Yes
Gene: THRB (ENSG00000151090)
DNA-binding domain: Nuclear receptor
Is a transcription factor: Yes
TF assessment: Known motif
Binding mode: 1 Monomer or homomultimer
Motif status: High-throughput in vitro
Reviewer 1 (Sam Lambert) assessment: Has known motif; binding: 1 Monomer or homomultimer
Reviewer 2 (Yimeng Yin) assessment: Has known motif; binding: 1 Monomer or homomultimer
CisBP considers it a TF: Yes
TFclass considers it a TF: Yes
TF-CAT classification: TF Gene_DNA-Binding: sequence-specific_DNA Binding; Transactivation_PMIDS:1648450;1648451
Annotated as a GO transcription factor: Yes