Reviewer’s report
Title: 
Nodular malignant melanoma in vulvar skin without pigmentation: a case
report
Version: 
1 
Date: 
22 Mar 2021
Reviewer's report:
The paper by Nie et al is a case report describing the occurrence of a vulvar
malignant melanoma. There are several reports of amelanotic malignant
melanoma of the vulva already published in the literature. The quality of the
manuscript as it is written is low. Most of all, the results are very unclearly
described. Below are some of my main concerns.
* The title is misleading. It would be more appropriate to specify "nodular
malignant melanoma" in the title.
* Histopathological findings: What was the stage of the tumour? The invasion
depth, the mitotic rate? The thickness of the tumour (Breslow)? These points are
crucial to characterise the tumour.
* How were the lymph nodes assessed? Did the authors perform sentinel lymph
node biopsy if the nodes were clinically negative? Where any imaging methods
used?
* In what time period was the patient diagnosed?
* The abbreviations, such as "NM" and "CM" should be explained where they
appear in the text. 
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
No
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from apparent manipulation?
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