JerMa88/BMC_Womens_Health_Peer_Reviews huggingface dataset:
Title: Tolerability of endometriosis medical treatment: a comparison between combined
hormonal contraceptives and progestins
Version: 2 Date: 06 Aug 2023
Reviewer:  Pedro-Antonio Regidor
Reviewer's report:
The paper is very interesting.
Some points regarding the drop out rate should nevertheless be improved.
The main comparison result is missing.
Was the drop out rate higher in the COC or in the POP group.
If 142 started with a COC and 184 with a POP:  What was the drop out rate of each group?
It is only mentioned that 177 discontinued and that 153 not. This measn that the treatment
efficacy was below 50 %.
And if from the 177, 144 received a new tratment ; what happend with the remaining patients?
At which time was the switch performed. This is more a treatment change ; not a study on drop
out rates.
This has to be clarified.
Title: Factors associated with vulvar cancer from 2005 to 2021 in Togo, Sub-Saharan Africa
Version: 1 Date: 16 Jul 2023
Reviewer's report:
Subject: It 's a public health concern. It is one of the rare study dealing with associated factors
in sub sahara.
The whole work need to be improved.
1 Tittle: it is unclear: Data concern only Togo even only a teaching hospital.
Do you think the result can be extrapolated to the whole Sub sahara Africa?
The tittle should include the years cover by data
2 Abstract:
-Background Remplace risk factors by associated factors
-Method: Type of study a cross sectional one as the data collection .
was done only one time. It is not a cohorte nor a retrospectif case control
3 Banckgrounds
to be improve there is no transition, connexion between paragraphs
Authors must more show t the interest and added value of the study
4 Method
It need to be improved too short and unclear: We can't see all the variable of interest
-Study type: it's a cross sectional study
-Study population: Organise more this section
-Data processing need to be more developed. It must be consistent with results you develop
5- Results
We can see in this part some results which were not listed like a variable of interest and not
included in objectives: Therapeutic and pronostic
Authors talk about multivariate analysis which were not developped in method
-Tables
Tittles need to be improved; they are unclear and not consistent with the contain
Talk about associated factors not risk factors as the study is not an experimental; a cohort study
nor a case control study.
6-Discussion
Explain more why ulcero-budding migth be the most predominant.
Therapeutic aspect which is more discussed is not part of the objectif nor listed like variable
of interest
7- Conlusion Need to be improved.
The recommandation is not public health focused
Title: Factors associated with vulvar cancer from 2005 to 2021 in Togo, Sub-Saharan Africa
Version: 1 Date: 05 Aug 2023
Reviewer:  Donatien Moukassa
Reviewer's report:
Title : Factors associated with vulvar cancer in Togo, Sub-Saharan Africa
Authors : Tchin Darré1*; Bagassam Sama1; Toukilnan Djiwa1; Whitney E.D. Afantodji-
Agbeti1;   Mayi Bombone1;  Kambote Yendoubé2; Panakinao Simgban1; Bingo K
M’Bortche2; Baguilane Douaguibe2; Koffi Amégbor1; Mazamaesso Tchaou3; Abdoul-
Samadou Aboubakari2; Bayaki Saka4 and Gado Napo-Koura1
Origin: Department of Pathology, University Teaching Hospital of Lomé, Togo
Form: no problem
Background:
1) First, a few clarifications to be provided by the authors, concerning the approach to variables.
In the chapter on "Materials and methods", the authors state that they have used only histological
data from biopsies. How can they include comments on clinical and therapeutic aspects in the
results and discussion?
2) Secondly, it would be simpler to include clinical and therapeutic aspects in the study variables,
to justify the deferral of clinical examination data, and prognostic elements for evolutionary and
therapeutic follow-up.
3) Thirdly, how were they able to diagnose HPV infection without using immunohistochemistry
or PCR?
Conclusion: we recommend publication of this article after clarifying and correcting these minor
inconsistencies.
Title: Number of vaginal lactobacilli in postmenopausal women with vaginal atrophy before
and after treatment with erbium YAG laser, a randomized sham-controlled trial
Version: 1 Date: 18 Nov 2022
Reviewer's report:
Dear Authors,
Thank you for the work on the manuscript. I have reviewed the manuscript and would like to
suggest the following changes:
1. Please divide the methodology into subsections based on the CONSORT 2010 checklist for
increased brevity.
2. Please double-check the manuscript for grammatical errors.
3. Discussion lacks critical analysis of published literature. I suggest the authors to rewrite it in
a detailed fashion and focus more on the clinical implications of the findings.
Title: Number of vaginal lactobacilli in postmenopausal women with vaginal atrophy before
and after treatment with erbium YAG laser, a randomized sham-controlled trial
Version: 1 Date: 20 Nov 2022
Reviewer's report:
The study  provide  some new information. The age difference  in two group should be disscused.
The vaginal lactobacilli grade diferences  may  come from age difference . The  main finding
of the study may be the vaginal atrophy symptoms improvement and  vaginal atrophy score
improvement. The analysis comparation after treatment in two group is reqired(not just before
and after).
Title: Number of vaginal lactobacilli in postmenopausal women with vaginal atrophy before
and after treatment with erbium YAG laser, a randomized sham-controlled trial
Version: 5 Date: 07 Mar 2023
Reviewer's report:
I read with great interest the manuscript, which falls within the aim of this Journal. In my honest
opinion, the topic is interesting enough to attract the readers’ attention. Nevertheless, the authors
should clarify some points and improve the discussion, as suggested below.
Authors should consider the following recommendations:
- Manuscript should be further revised in order to correct some typos and improve style.
- I suggest to highlight that post-menopausal period may be associated with higher risk
of developing micotic infection due to vulvovaginal atrophy (authors may refer to: PMID:
34703415; PMID: 29452786).
Title: Number of vaginal lactobacilli in postmenopausal women with vaginal atrophy before
and after treatment with erbium YAG laser, a randomized sham-controlled trial
Version: 6 Date: 21 Apr 2023
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: I carefully evaluated the revised version of this manuscript.
The authors have performed the required changes, improving significantly the quality of the
paper."
Title: Number of vaginal lactobacilli in postmenopausal women with vaginal atrophy before
and after treatment with erbium YAG laser, a randomized sham-controlled trial
Version: 6 Date: 05 May 2023
Reviewer:  Giuseppe Gullo
Reviewer's report:
Dear authors,
I read with great interest the manuscript, which falls within the aim of this Journal. In my honest
opinion, the topic is interesting enough to attract the readers’ attention. Nevertheless, authors
should clarify some points and improve the discussion, as suggested below. Authors should
consider the following recommendations:
In my opinion you have to refer how the  vaginal lactobacilli in postmenopausal women
with vaginal atrophy  can be helpfull also in pts that have urinary incontinence  as well after
surgery treatments as bobotic surgery oruterus transplantation and as good alternative to sacral
neuromodulation for refractory lower urinary tract dysfunctions.
I suggest you to read and cite these articles:
Urinary incontinence and quality of life in high-performance swimmers: An observational study
Sacral neuromodulation for refractory lower urinary tract dysfunctions: a single-center
retrospective cohort study
The reproductive potential of uterus transplantation:future prospects
Robotic Surgery in Female-To-Male Transition: A Possible Way for Further Improvement
Title: Number of vaginal lactobacilli in postmenopausal women with vaginal atrophy before
and after treatment with erbium YAG laser, a randomized sham-controlled trial
Version: 6 Date: 06 May 2023
Reviewer:  Ilaria Cuccu
Reviewer's report:
I read with great interest the Manuscript titled “Number of vaginal lactobacilli in postmenopausal
women with vaginal atrophy before and after treatment with erbium YAG laser, a randomized
sham-controlled trial.“.  In my opinion, this topic analyzed is interesting enough to attract
readers’ attention.
The abstract is very clear, well structured and highlights the results obtained in the study. Tables
are clear and interesting.
Nevertheless, authors should clarify some points and improve the quality of manuscript citing
relevant and novel key articles about the topic:
- I suggest a round of language revision, in order to correct few typos and improve readability.
- The authors could extend and improve the discussion by evaluating and citing current evidence
about the use of CO2 laser for treatment of genitourinary syndrome of menopause. I would be
glad if the authors discuss this important point, referring to PMID: 32720802 and Di Donato
V, D'Oria O, Giannini A,  Scudo M, Sher C,  Fischetti M,  et al.. The Efficacy of Fractional
CO2 Laser in the Treatment of Genitourinary Syndrome of Menopause: A Large Prospective
Observational Study. Clin. Exp. Obstet. Gynecol. 2022, 49(9), 212. https://doi.org/10.31083/
j.ceog4909212
Because of these reasons, the article should be revised and completed. Considering all these
points, I think it could be of interest to the readers and, in my opinion, it deserves the priority
to be published after minor revisions.
Title: Number of vaginal lactobacilli in postmenopausal women with vaginal atrophy before
and after treatment with erbium YAG laser, a randomized sham-controlled trial
Version: 9 Date: 08 Jun 2023
Reviewer:  Ilaria Cuccu
Reviewer's report:
I read with great interest the Manuscript titled " Number of vaginal lactobacilli in
postmenopausal women with vaginal atrophy before and after treatment with erbium–YAG
laser: A randomized sham-controlled trial” , topic interesting enough to attract readers' attention
The quality of the manuscript has improved thanks to the changes made. The methodology
is accurate, and conclusions are supported by data analysis. The discussions are clear and
comprehensive. References are relevant to the search.
Considering all these points, I think it could be of interest to the readers and, in my opinion, it
deserves the priority to be published.
Title: Number of vaginal lactobacilli in postmenopausal women with vaginal atrophy before
and after treatment with erbium YAG laser, a randomized sham-controlled trial
Version: 9 Date: 08 Jun 2023
Reviewer:  Giuseppe Gullo
Reviewer's report:
Dear authors,
I read with great interest the manuscript, which falls within the aim of this Journal. In my honest
opinion, the topic is interesting enough to attract the readers’ attention. Nevertheless, authors
should clarify some points and improve the discussion, as suggested below. Authors should
consider the following recommendations:
In my opinion you have to improve the paper   refering if the treatment could be helpfull after
OTC or surgery treatments as  Utero-cutaneous fistula .
I suggest you to read and cite these articles:
Ovarian tissue cryopreservation and transplantation in menopause: new perspective of therapy
in postmenopausal women and the importance of ethical and legal frameworks
Utero-cutaneous fistula after caesarean section delivery: diagnosis and management of a rare
complication
Sacral neuromodulation for refractory lower urinary tract dysfunctions: a single-center
retrospective cohort study
Uterine Involvement in Klippel- Trenaunay Syndrome: A Rare But Relevant Event. Review of
the Literature
Title: Number of vaginal lactobacilli in postmenopausal women with vaginal atrophy before
and after treatment with erbium YAG laser, a randomized sham-controlled trial
Version: 9 Date: 10 Jun 2023
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: I carefully evaluated the revised version of this manuscript.
The authors have performed the required changes, improving significantly the quality of the
paper.
ADDITIONAL REQUESTS/SUGGESTIONS:
I carefully evaluated the revised version of this manuscript.
The authors have performed the required changes, improving significantly the quality of the
paper."
Title: Number of vaginal lactobacilli in postmenopausal women with vaginal atrophy before
and after treatment with erbium YAG laser, a randomized sham-controlled trial
Version: 11 Date: 05 Aug 2023
Reviewer:  Ilaria Cuccu
Reviewer's report:
The quality of the manuscript has improved thanks to the changes made. I think it could be of
interest to the readers and, in my opinion, it deserves the priority to be published.
Title: The long non-coding RNA BBOX1 Antisense RNA 1 is upregulated in polycystic ovary
syndrome (PCOS) and suppresses the role of microRNA-19b in the proliferation of ovarian
granulose cells
Version: 3 Date: 15 Apr 2023
Reviewer:  Hussein Wahhab Saleh Rabeea
Reviewer's report:
* At the end of the introduction, give an idea about your work
*  There are statistics that must be mentioned about the country in which you live first, and then
on the external level, not only on the global level
* The Tittel would be changed to (The long non-coding RNA BBOX1 Antisense RNA 1 is
upregulated in polycystic ovary syndrome (PCOS) and suppresses the role of microRNA-19b
in the proliferation of ovarian granulose cells)
*There are some spelling errors that should be corrected
* The name of the device used and the method of work must be mentioned in all the devices
used, along with mentioning the name of the source of the work method
Title: The long non-coding RNA BBOX1 Antisense RNA 1 is upregulated in polycystic ovary
syndrome (PCOS) and suppresses the role of microRNA-19b in the proliferation of ovarian
granulose cells
Version: 3 Date: 23 Apr 2023
Reviewer's report:
Good work, overall.
the background was well written, but i think you should avoid the referral to herbal treatment
and mention some of the current treatment strategies that include scientifically approved drugs.
The material and methods was good, apart from some missing information about measurement
of noncoding RNAs in patients follicular fluid.
Results and discussion were laid down in a proper scientific way and I enjoyed reading them.
Line 38 - "MicroRNA-19b" instead of "MicriRNA -19b"
Line 41 - this statement should be replaced (We then studied their interaction in PCOS )
Line 53 - the word (sponge) is not scientifically appropriate and should be replaced with a better
synonym  (it is repeated in conclusion and results)
Line 73 - "pregnancy" instead of "pregnant"
Line 74 - "treatment" instead of "administration"
Lines 76-78 - replace this with studies involving drugs or treatment methods other than herbs
Line 101 - include a reference for (Rotterdam revised criteria )
Line  155 - "Nuclear" instead of "Nulear"
Line 156 - "Two" instead of "Tow"
Line 198 - "nucleus" instead of "nuclear"
Lines (176-178) - your are discussing the results of expression of miR-19b and BBOX1-AS1 in
follicular fluid which was not explained in methods
Line 243 - "ovaries" instead of "ovarian"
Title: The long non-coding RNA BBOX1 Antisense RNA 1 is upregulated in polycystic ovary
syndrome (PCOS) and suppresses the role of microRNA-19b in the proliferation of ovarian
granulose cells
Version: 3 Date: 03 May 2023
Reviewer:  Fatima Mutasher Swadi
Reviewer's report:
Dear editor i would like to thank you for your trust to allow me to revise this article.
Apart from the discussion all the suggested tasks has been done
Only the discussion need to be more correlated with the subject and described in more signtific
detailes.
With my great appriciate.
Title: The long non-coding RNA BBOX1 Antisense RNA 1 is upregulated in polycystic ovary
syndrome (PCOS) and suppresses the role of microRNA-19b in the proliferation of ovarian
granulose cells
Version: 5 Date: 05 Jul 2023
Reviewer:  Hussein Wahhab Saleh Rabeea
Reviewer's report:
Dear editor, I would like to thank you for your trust in allowing me to revise this article.
The material and methods were good, apart from some missing information about some words
Title: The long non-coding RNA BBOX1 Antisense RNA 1 is upregulated in polycystic ovary
syndrome (PCOS) and suppresses the role of microRNA-19b in the proliferation of ovarian
granulose cells
Version: 5 Date: 15 Jul 2023
Reviewer:  Fatima Mutasher Swadi
Reviewer's report:
Dear editor i would like to thank you for your trust to allow me to revise this article
ALL the suggested tasks has been done. My suggestion for the article is to be accepted.
With my great appriciate.
Title: Impact of nausea/vomiting on EQ-5D-5L utility scores in patients taking iron preparations
for heavy menstrual bleeding or anemia
Version: 1 Date: 29 Jun 2023
Reviewer:  Andrew Lloyd
Reviewer's report:
I think the team should be congratulated on conducting this very useful study which both
highlights the impact of nausea for women and also nicely estimates the disutility for this.  Its
also a very interesting demonstration that measures like EQ-5D are able to measure the burden
of something that is not explicitly referred to in the 5 questions which is a point perhaps worth
making.
EQ-5D-5L is not an acronym -  that is the name of the instrument.  So you shouldn’t refer to
the EuroQoL-5 dimension-5 level.
Page 7 This sentence needs tweaking “This study was a cross-sectional web-based survey
questionnaires on a personal computer, a cell phone or a tablet, and the data were collected from
patients taking iron preparations for HMB or anemia.”
Page 8 -  did you do any testing on these survey items you developed to see if people understood
them in the way you intended?   It’s a good idea to work with a Doctor but you should also test
novel items with patients
Page 8 -  lots of people may feel tired – especially if they have young children and busy work,
but that doesn’t necessarily mean they have anemia.  Can you clarify if the women classified as
anemic actually had anemia defined by blood Hb levels?
Page 13 – can you clarify what this means “one of them was selected from the viewpoint of
clinical and versatility”
Page 18 – I understand that you consider it important to highlight cultural differences and their
possible impact on HRQL scores – but I feel a little uncomfortable with the suggestion that the
fact that the study is Japanese is a limitation.  I don’t think European or American writers would
ever suggest that about their own data – so perhaps you could rephrase slightly.
If you are simply trying to understand predictors of EQ-5D in women with HMB I’m not sure
that you need to divide the sample into two datasets.  I think this step is a little unnecessary, you
could simply just report the analyses of the total sample.  Can you explain why you have done
this, I'm not 100% convinced that its needed.
Title: Impact of nausea/vomiting on EQ-5D-5L utility scores in patients taking iron preparations
for heavy menstrual bleeding or anemia
Version: 4 Date: 05 Sep 2023
Reviewer's report:
The authors have provided clarification to my questions and have sufficiently addressed
comments within the revised manuscript. The phrasing is still a little unclear regarding the
determination of anaemia in participants however overall, this article is a useful addition to the
literature by demonstrating the impact of nausea and vomiting on quality of life for women as
a common side effect of iron treatment preparations, and does a thorough job of quantifying
the disutility.
Title: The association between sexual function, quality of marital relationship and associated
factors in women with a history of ectopic pregnancy: A cross-sectional study in Iran
Version: 1 Date: 01 Jun 2023
Reviewer's report:
Comments to the Author
Thank you providing me with the opportunity to read this work. Your manuscript need more
work. This article has the problems mentioned below.
Overall, the ENTIRE of your manuscript needs scientific editing.
Abstract:
Please check and edit:
“…….decreased sexual function, but increased quality of marital relationships (P < 0.001,
increased sexual function in women.”?
“…….is suggested that women's sexual health units…”.  Do you mean women's sexual health
clinic?
Introduction:
In the introduction, there are no statistics on the quality of marital relationship in the world and
Iran.
At the end of the introduction, a lot of emphasis is placed on the importance of conducting a
study in Iran?!! This emphasis reduces the generalizability of the results.
Method:
The main criticism is the design of the study:
Since the direct relationship between sexual function and the quality of marital relationship is
clearly mentioned in the introduction, it seems that it would be better to compare sexual function
and the quality of marital relationship in two groups of women with and without a history of
ectopic pregnancy.
Results:
Table data is repeated in the text.
Figures can be removed.
Table titles need correction.
In the results and discussion section, there is a lot of explanation and emphasis on the relationship
between sexual function and the quality of marital relationship with demographic variables, and
it seems to be one of the main objectives of the study, but it is not mentioned in the title and
introduction.
“Based on the findings …………….. and female occupation affect?! quality of relationship with
their spouse.”
Discussion:
The discussion is weak and superficial.
There are explanations that are not related to the findings, and no reference is provided for them,
such as: “because women in many cultures, including Iranian culture, are indifferent to SD, if
they suffer from it, they remain silent as they have conservative beliefs and limited information
about sexual function.”