Title: The impact of a lifestyle promotion program on anthropometric and clinical
manifestations in adolescents with polycystic ovarian syndrome: a randomized controlled trial
Running title: Lifestyle promotion program in adolescents with polycystic ovarian syndrome
Version: 6 Date: 05 Jul 2024
Reviewer's report:
Dear authors,
Thank you for considering the comments and essential rectifications. However, it is vital to pay
consideration to a few other focuses. These include the following:
Introduction
- Line 112-119; “The negative impact of PCOS on physical appearance … in a common
environment such as school”: Provide the references.
- Line 125-128; “Although plenty of studies have investigated lifestyle … (12), … aspects of
PCOS (12)”: Reference 12 is repeated twice. Be checked.
Materials and methods
- The time of research should be stated in the trial design section.
- In the section participants, the verbs need to be past in the result section. It is necessary to
revise this paragraph; “Adolescents 14 to 18 years old … were not important for entry.”
- Reference 25 should be cited after “for three months ago”.
- Line 201-203: The sentence should be revised to: Participants were divided into two subgroups,
including PCOS and non-PCOS intervention at school for the intervention and PCOS and non-
PCOS control at school for the control.
- Line 219 in the intervention section: What about the control group?
- Line 226: “In training sessions, the adolescents were advised to increase their physical activity
and follow …”
- Line 234-237 the last paragraph of the intervention section; “To guarantee access to educational
materials …” should be revised to: To ensure that all youth had access to educational materials,
a special CD containing eight learning sessions was produced and distributed to all students in
the intervention group along with an educational notebook produced by the research team.
Result
- In the first paragraph “… seven were excluded at the 12-month follow-up”: It does not match
with consort. (2+2+4=8). It is necessary to be rechecked.
- Line 340-341: This sentence (regularity of menstrual cycle in the non-PCOS intervention group
…) must be revised agreeing to the table (PCOS Intervention VS. PCOS control).
- Line 342: P value must be changed agreeing to the table (p=0.004).
Line 349: Is this sentence (there was significant statistical difference in the mean change of the
groups in (p<0.05)) related to Table 5? The writing needs to be more concise.
- Line 351-353; The sentence should be revised to: “Table V reveals that the physical activity of
girls increased after 12 months of follow-up by 38.13 Met/ min/week (12.14, 110.42) (P=0.04)
in the PCOS intervention group compared to the PCOS control group and by 161.38 Met/ min/
week (84.42,238.35) (P<0.001) in the non-PCOS intervention group compared to the non-PCOS
control group.”
Discussion
- Line 394, discussion: By 4 is correct? It is considered that 0.46 and 0.44 are correct.
- The practical implications should be written in the conclusion section.
Figure 1: Diagram
- The consort diagram should be completed. The analysis segment needs to be included.
Table II
- These numbers (related to SBP and DBP) are not considered correct for SBP and DBP in
adolescence. It is required to recheck all of these means and SD carefully.