Reviewer’s report
Title: 
Factors associated with mammographic breast density among women in
Karachi Pakistan
Version: 
0 
Date: 
17 Jul 2021
Reviewer: 
Nutthada Areepium
Reviewer's report:
1. The term premenopausal and menopausal in the title is not necessary, only the
word "women" is adequate.
2. Background: 
Breast cancer prevalence and current status of mammography in Pakistan should
be mention to state the importance of this study.
3. Materials and Method: 
It is unclear about the study design as well as the objectives of this study. 
It seems like this study is secondary analysis of other study, however, the
subjects included in this analysis may not be good candidate for using this type
of analysis. 
Written style in this part is quite hard to understand. How patients interviewing
was done and by whom should be explained more details.
Sample size calculation should be address.
The program for statistical analysis (SPSS or STATA) should be specified. 
4.Results: 
Comparison data to other population should be moved to discussion part. 
In table 1, education is quite not related with the findings, should be deleted from
the table.
Figure 4 can be deleted since the presented info is redundant with table 1 
The statistical analysis for table 3 should be addressed, it is unclear whether this
table using Chi-square or regression.
The association between vitamin d level and dietary pattern should be analysed.
5. Discussion
The writing pattern in discussion part is quite hard to follow, the author should
report their finding and refer to comparable studies first either in Caucasians or
Asians, then mentioned the similarities or contrary results from other studies if
available. The number or percentage of similar findings should be addressed for
reader to see whether how much they similar or different. 
The first and second paragraph should be moved to conclusion.
The repeated words such as our study finding should be replaced with other
synonyms in several places 
6. Limitation
The appropriateness of study population and sample size should be mentioned. 
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
No
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
No