Reviewer’s report
Title: 
CCDC114, DNAI2 and TOP2A  involves in the effects of Tibolone
treatment on postmenopausal endometrium
Version: 
0 
Date: 
24 Jan 2020
Reviewer's report:
1. the rationale is not clear. 
Because this medication(i.e. 
Tibolone ) used starting
long years back and the innovators know the mechanism better than you
specified.
2. What will be the value/importance for scientific world.
3. There are different RCTs done before.
4. The title does not describe the outcome.
5.The authors are from two departments (medicine and obs/gyn) expected having
less knowledge on gene analysis. It would be better to include from genetic/bio-
engineering department or other department who have better knowledge on the
details of the study
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
No
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the
authors.
Unable to assess
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you
recommend an additional statistical review?
If an additional statistical review is recommended, please specify what aspects
require further assessment in your comments to the editors.
Not relevant to this manuscript
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
Declaration of competing interests
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questions:
1
. 
Have you in the past five years received reimbursements, fees, funding, or
salary from an organisation that may in any way gain or lose financially
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3
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Do you hold or are you currently applying for any patents relating to the
content of the manuscript?
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Have you received reimbursements, fees, funding, or salary from an
organization that holds or has applied for patents relating to the content of
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Do you have any other financial competing interests?
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Do you have any non-financial competing interests in relation to this
paper?
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interests' below. If your reply is yes to any, please give details below.
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