Reviewer’s report
Title: Blood Pressure after PREeclampsia/HELLP by SELF monitoring (BP-PRESELF): rationale
and design of a multicenter randomized controlled trial
Version: 1 Date: 28 Oct 2019
Reviewer: Leila Katz
Reviewer's report:
Regarding the Manuscript BMWH-D-19-00079R1
First of all, I would like to thank authors for the opportunity of reviewing your manuscript.
This an interesting protocol about a very important topic.
Before further opinion, there is some point that need to be clarified.
First, and most important, it is fundamental that the sample size calculation is explained.
In the methods section you state: "Approximately 200 women aged 40-60 years with a previous
PE/HELLP in pregnancy will be included in the study."
This is very inappropriate you have to present how many patients during the observation period, are
expected  to  develop  hypertension,  and  how  many  more  happen  because  you  would  estimate
preeclampsia would increase that risk. From those numbers you would then calculate the sample size.
Secondly, I am worried about the observation period. Is one your observation enough for each women?
Maybe there are already studies pointing that this is all correct and enough, but then show the studies
that give you basis for this.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
No
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Unable to assess
Are you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?
If an additional statistical review is recommended, please specify what aspects require further
assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Acceptable
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