Reviewer’s report
Title: 
Menstrual, reproductive and hormonal factors and thyroid cancer: a
hospital-based case-control study in China
Version: 
0 
Date: 
23 Aug 2020
Reviewer's report:
This is an interesting case - control study to investigate the associations between
menstrual, reproductive and hormonal factors with thyroid cancer occurrence in
a population of Chinese women. 
It is a well-written research work with an
interesting subject. In my opinion, the paper needs a minor revision. I have
provided comments below for the authors to consider in revising the manuscript.
My comments are as follows:
Method
* It is necessary to define the term "thyroid cancer".
* Please indicate the type of study in the method section.
* Please describe how the reliability of the questionnaire were determined?
* How we can confirm the sample size? How was the sample size calculated for
study? 
Results:
* In the results section, you mentioned that in the present study, we only
included the female subjects in the analysis process. Why didn't you consider
being a female as one of the entry criteria?
* Table 1, In the column of Factors, the unit for BMI should be listed.
Discussion
* Please present some underlying pathophysiology associated with findings. It is
suggested to discuss the possible mechanisms of relation of reproductive and
hormonal factors with thyroid cancer.
* Please add some scientific use for the findings of this study. 
Conclusion
Please state that how these results can help us for better management of women
with thyroid cancer.
Ethics approval and consent to participate
Please mention the approval number in the Ethics approval section.
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Declaration of competing interests
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paper?
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interests' below. If your reply is yes to any, please give details below.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
No
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes