Reviewer’s report
Title: 
Postmenopausal hyperandrogenism due to an ovarian sex cord-stromal
tumour causing elevated Dehydroepiandrosterone sulfate; a case report
Version: 
0 
Date: 
30 Oct 2021
Reviewer's report:
I read with great interest the manuscript, which falls within the aim of this
Journal. In my honest opinion, the topic is interesting enough to attract the
readers' attention. Nevertheless, authors should clarify some points and improve
the discussion, as suggested below.
Authors should consider the following recommendations:
- Manuscript should be further revised in order to correct some typos and
improve style.
- I suggest to highlight, at least briefly, that the differential diagnosis with other
causes of hyperandrogenism (and in particular of Dehydroepiandrosterone
sulfate), 
is mandatory to rule out PCOS and other endocrinological disorders
(authors may refer to: PMID: 26927948; PMID: 27579037).
- One of the main important problems regarding ovarian cancers is the recurrence
after surgery and first line chemotherapy. Usually, the recurrence of the disease
poorly responds to first, and sometimes even second line chemotherapy. In this
scenario, it is possible that the ovarian cancer inherent resistance may be due to
reduced immunosurveillance and drug-resistant cells. Authors should discuss
this hypothesis, referring to: PMID: 27995176; PMID: 26513872; PMID:
30304728.
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