Reviewer’s report
Title: 
Uterine rhabdmyosarcoma complicated by cerebral venous thrombosis and
uterine inversion in a young woman: Case report and literature review
Version: 
0 
Date: 
21 May 2021
Reviewer's report:
Thank you for the opportunity to review this case report and review of the
literature concerning an unfortunate young lady with rhabdmyosarcoma of the
uterus and a central venous thrombosis. This is indeed a rare occurrence for both
events never mind both occurring in the same person. I have the following
questions and suggestions:
Questions
1. Did the patient suffer any complications from the inadvertent hysterectomy at
time of tumor debulking that was done vaginally (ie., tied off ureter, bladder
injury)?
Suggestions
1. Abstract conclusion: Pg 3 Line 54 the word is "alert" not "alter"
2. Recommend adding a section titled methods. In this section could be a
statement of search terms, databases searched and the years of the literature
searched.
3. Line 68 - suggest adding information on her race, weight (or BMI),
medications, other medical history
4. Line 75 and 129 The word is "contraceptive" not "contracptive" 
5.Line 81 suggest the word "protruded" rather than "excreted"
6. Suggest more information about the workup prior to the surgery. Physical
exam - was there an abdominal mass identified? Was a stalk felt on pelvic exam?
Radiology preoperative of the chest abdomen and pelvis. Was a biopsy done and
did the team know the diagnosis preoperatively? Was a gynecologist or a
gynecologic oncologist involved preoperatively?
7 Line 139 Another reason for cerebral vein thrombosis in the era of COVID is
exposure to the Astra Zeneca vaccine. Was this in the patient's history?
8. Fig 1 description. Would provide date or time in the disease course ie., x
month post chemotherapy ect.
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