JerMa88/BMC_Womens_Health_Peer_Reviews huggingface dataset:
Title: Associations between serum cytokine levels and postmenopausal depression in
postmenopausal women with and without menopause hormone therapy
Version: 8 Date: 08 Jan 2025
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The main objective of this study was to investigate the relationship
between pro-inflammatory cytokines and depressive symptoms in postmenopausal women,
while considering the potential influence of menopause hormone therapy (MHT). The authors
have properly responded to the questions previously raised, explaining their reasoning when not
including some new data. Mostly, including cytokine differences in Table 3 and other variables´
comparisons (included in Table 4). They have included the necessary text modifications into the
current version of the manuscript. The current version is more clear. They point that menopausal
depressive symptoms in relation to inflammatory markers would be further investigated, and the
topi remains relevant to the scientific community. The current version of this study contributes
to understanding the biological mechanisms underlying menopausal depression and highlights
the potential role of MHT in modulating inflammatory responses and associated outcomes.
Title: Behavior changes to promote preconception health: A systematic review
Version: 0 Date: 11 Oct 2024
Reviewer's report:
I commend the authors for conducting a review on preconception health given that there has
been more emphases on pregnancy and postnatal research to date.  However, the rationale for
conducting this systematic review is not convincing. In the introduction section of the manuscript
authors have written "Some review studies did not limit the study setting or topic[4, 13], " but
the current review has not done this either.  Authors also indicated that
"there have been no reviews of recent findings" which I do not think is accurate. Please see the
below papers:
https://rjptonline.org/AbstractView.aspx?PID=2023-16-11-81
(Literature search up to March 2023)
https://onlinelibrary.wiley.com/doi/full/10.1111/1747-0080.12842
(Literature search up to Nov 2022)
I found the aim of the review quite vague: "We aimed to identify and examine preconception
care programs delivered to reproductive-aged women and men to promote behavioral change."-
What are you examining specifically in the programs? Based on the results presented in the
review it seems  that the characteristics and effectiveness of the interventions were examined.
Please also explain how your data extraction methods relate to your revised aim.
Can you provide further information about the inclusion criteria? Stepped wedge RCTs were
reported in the results but not mentioned in the inclusion criteria. What type of preconception
program could be included? Could they target any type of risk factor (e.g. diet, physical activity
etc.) What specific populations were included? Women and men of childbearing age?  This
wording is quite vague "people already receiving treatment or care for specific reasons."
I have concerns about the comprehensiveness of the literature search strategy as only three
databases were used and two of these databases were in Ovid. Did you manually check the
reference list of other systematic reviews to ensure that no trials were missed?
If only one reviewer assessed the full-text articles this needs to be acknowledged as a limitation
in the discussion section.
In the results section it is difficult to understand the effectiveness as the interventions were
grouped together based on the mode of delivery. All interventions targeted different risk factors
so they are not very comparable when group together.  Could you separate the studies based on
the risk factor targeted? It would be helpful if the range in sample sizes was also reported to get
a sense of strength of evidence.
In the discussion section please avoid reporting the specific results again. Take a broader
perspective and identify the major findings from the review. Grouping the studies by risk factors
in the mode of delivery may provide more clarifying about where there is convincing evidence
regarding effectiveness and help guide future research. At the moment the discussion does not
provide any insight into what type of intervention might be effective based on mode of delivery
and/or risk factor targeted.
Title: Behavior changes to promote preconception health: A systematic review
Version: 1 Date: 05 Dec 2024
Reviewer's report:
Overall, this study was well-conducted and the manuscript was a pleasure to read. I only have
minor comments.
Abstract:
- Lines 42-43: Could the authors state the direction of the effect?
Background:
- The authors provide a thorough background of the importance of preconception care for
women, but I would recommend further expanding the background on the importance of
preconception care for men.
- Line 64: Very minor, but I would advise replacing "pre-conception" with "preconception" to
maintain consistency throughout the text.
Methods:
- I had difficulty understanding the difference between "health outcomes" and "other health
outcomes". Perhaps it would be helpful to provide a definition.
- Line 104: I am wondering why studies on people with overweight and obesity were excluded.
Perhaps it would be helpful to provide some clarification and rationale on this, particularly
considering the introduction mentions the importance of pre-pregnancy BMI. Were studies
excluded if they included any people with overweight and obesity, or only if they were restricted
to people with overweight and obesity? I also noticed obesity is an eligible outcome, but I had
difficulty understanding how this would be relevant if people with overweight and obesity were
excluded from the review.
Results:
- Overall, the results were well-presented. I particularly appreciated Additional File 5
summarising the intervention topics.
- Figure 1: Very minor, but it appears that an arrow is missing between "Records identified from
initial searches" and "Records screened titles and abstracts".
Discussion:
- Overall, the discussion was well-conducted.
- Line 352: Should "preconceptions of health" instead be "preconception health"?
- Line 420:  Could the authors expand on the need for outcomes to be reported uniformly?
Perhaps a mention of core outcome sets could be helpful.
Title: Impact of Family Care on Sleep Quality in Perimenopausal Women: Mediating Roles of
Anxiety and Depression
Version: 5 Date: 01 Nov 2024
Reviewer:  Henny Dwi Susanti
Reviewer's report:
Background:
add references each sentences at background
add the novelty your research
add some research that correlates with your research
Sampling:
How do you calculate of the sample size, use G-power analysis, please
Discussion:
Please add explanation for the discussion and compare previous article with correlate your
research
Title: Impact of Family Care on Sleep Quality in Perimenopausal Women: Mediating Roles of
Anxiety and Depression
Version: 6 Date: 13 Dec 2024
Reviewer:  Henny Dwi Susanti
Reviewer's report:
Dear
1. The abstract could better emphasize the practical implications of the findings
2. What specific types or forms of family interventions can be implemented to improve sleep
quality in perimenopausal women in resource-limited settings?
3. How do local cultural values and traditional beliefs influence the relationship between family
support, anxiety, depression, and sleep quality in perimenopausal women?
4. Does the effect of family care on sleep quality remain consistent over time? Longitudinal
studies could help determine whether these effects are temporary or enduring.
5. To what extent do other factors, such as socioeconomic status, occupation, or lifestyle,
contribute to sleep quality compared to the effects of family care, anxiety, and depression?
Title: Impact of Family Care on Sleep Quality in Perimenopausal Women: Mediating Roles of
Anxiety and Depression
Version: 7 Date: 22 Dec 2024
Reviewer:  Henny Dwi Susanti
Reviewer's report:
Abstract
The abstract provides an overview of the study’s aim but could benefit from more explicit
emphasis on the significance of identifying the mediating roles of anxiety and depression in
family care and sleep quality.
Ensure that the selected keywords accurately reflect the core themes of the article, such as
"mediating effects" or "family functioning."
Introduction
Incorporate data or insights from regions outside Gansu to provide a broader global context,
which could increase the article's general appeal.
Include clearly stated hypotheses to help readers understand the anticipated relationships
between the key variables before delving into the methods.
Methods
Sampling and Representativeness: Discuss why Gansu Province was selected and how the
findings might be applicable to a broader population.
Validation of Instruments: While the scales used are well-explained, add information on the
validity and reliability of the instruments in the context of this study.
Results
Include additional graphs or tables to visually demonstrate the correlations between variables
like anxiety, depression, and sleep quality.
Provide more insight into potential causes of variability in the data, such as demographic or
cultural factors influencing anxiety and depression levels.
Discussion
Expand the discussion on results that diverge from previous studies, offering potential
explanations for these discrepancies.
Include more specific recommendations for implementing family-centered interventions in
community health or hospital settings.
Conclusion
Strengths and Limitations: Organize a more detailed subsection discussing the study’s strengths
and limitations systematically.
Recommendations for Future Research:
Clearly outline what future researchers should explore, such as longitudinal studies or
multicultural approaches.
References
Ensure all references cited in the text are included in the reference list and formatted according
to the journal’s guidelines.
Incorporate more references from the past five years to improve the study’s relevance.
Title: The meaning of trust along the treatment pathway of women with breast cancer: A mixed-
methods study among cancer survivors
Version: 3 Date: 13 Sep 2024
Reviewer's report:
Rewiewer comments:
Title: The meaning of trust along the treatment pathway of women with gynecological cancer:
A mixed-methods study among cancer survivors
Thank you for giving me the opportunity to review this manuscript, which according to the
document 'point-to-point response' and a tracked version of the manuscript, seems having
already undergone review previously, however not by me.
Overall impression:
The authors seem to have addressed the previous reviewer comments in a satisfactory way; the
manuscript is well written, the method is very interesting, and the topic is most relevant.
I have an important overall concern, though: Although there are similar challenges, it is well-
known that women with breast cancer and women with gynaecological cancer have quite
different treatment pathways, survivorship issues, and resources, which the authors actually
illustrate themselves in line 101-103.
Therefore, as only women with breast cancer did participate in the study I find it quite
misleading that they are called 'women with gynaecological cancer' in the title, manuscript and
supplementary. I strongly recommend the term 'women with breast cancer' – reflecting the actual
focus and population being investigated – to be used continuously: in title, manuscript, and
supplementary files.
Title: Clinical outcomes of a digital musculoskeletal women’s pelvic health program: an
observational, longitudinal study with comparison group
Version: 2 Date: 11 Oct 2024
Reviewer:  Maria Jesus Mena-Iturriaga
Reviewer's report:
I agree with the changes made by the article authors, I appreciate the consideration regarding
my suggestions and recommendations
Good job and I encourage you to keep developing this research area
Title: A comparative study of menstrual poverty among urban and rural female learners in
government schools of Zambia
Version: 2 Date: 18 Aug 2024
Reviewer:  Marjan Mardani-Hamooleh
Reviewer's report:
Follow the journal format in the text. Reference writing style is Vancouver.
Use references from the last 5 years.
You wrote: The study was designed as a cross-sectional study using a mixed method sequential
explanatory approach. This particular study design and approach where useful in obtaining
information that systematically described the problem. A reference is needed for this statement.
In method section, semi-structured questionnaires or semi-structured interviews? Which one of
these?
Write the interview questions completely. Also, write down the exact time and place of the
interviews.
Explain the thematic analysis with reference completely. Write what you did for rigor?
Title: A comparative study of menstrual poverty among urban and rural female learners in
government schools of Zambia
Version: 2 Date: 26 Aug 2024
Reviewer:  Hojjat Farahmandnia
Reviewer's report:
This is an interesting paper and the content is very good but I suggest the paper can be improved
in the following ways: Abstract
-Please correct all parts of the article according to the guidelines of the journal authors guideline
In the methods section please bring year of performing of this study, sampling methods and data
analysis methods -In the conclusion part, it is necessary to specify the researcher's proposal to
improve the conditions and use of the beneficiaries
Introduction
Please bring the following items 1- Definition of the research problem 2- The magnitude and
importance of the study variable 3- Expressing the necessity of conducting the study Finally,
the practical purpose of the study should be stated. Methods
Please report the details scoring and validations of study tools
Discussion
In the discussion section, it is necessary y to compare the main results of the study with the
results of other studies in this field. To strengthen the article, especially in the introduction and
discussion section the following studies are suggested, please used and add to this manuscript
references.
- The effect of bio ethical principles education on ethical attitude of prehospital paramedic
personnel
- Investigating the burden of disease dimensions (time-dependent, developmental, physical,
social and emotional) among family caregivers with COVID-19 patients in Iran
-Emotional Intelligence and Self-Efficacy among deputy's administrative staff of Kerman
University of Medical Sciences
Emotional intelligence and learning strategies of postgraduate students at Kerman University of
Medical Sciences in the southeast of Iran
Conclusion # What are your suggestion for future studies? Best regards
Title: A comparative study of menstrual poverty among urban and rural female learners in
government schools of Zambia
Version: 2 Date: 05 Sep 2024
Reviewer:  Grzegorz Bakalczuk
Reviewer's report:
Introduction is clear and simple. It explains well the background to the study.
All procedures have been followed for health and safety of all participants.
Methods used for this study were appropriate for its aim. Results are clearly formatted and
presented. The results of all tests are accurately reported .
The conclusions and limitations are also well presented.
Therefore I recommend to accept this paper.
Title: A comparative study of menstrual poverty among urban and rural female learners in
government schools of Zambia
Version: 3 Date: 13 Oct 2024
Reviewer:  Grzegorz Bakalczuk
Reviewer's report:
Thank you for the opportunity to review this manuscript. The authors investigate a significant
aspect of menstrual poverty problem in Zambia. Thank you for the extensive improvements
made to the manuscript. The revisions you have implemented are sufficient to warrant
acceptance of the manuscript at this stage.
Title: A comparative study of menstrual poverty among urban and rural female learners in
government schools of Zambia
Version: 4 Date: 06 Nov 2024
Reviewer:  Antonio Bandala-Jacques
Reviewer's report:
Dear authors -
Thank you for submitting your reviewed manuscript.
May I offer the following comments:
A) Overall, I can only some minor style issues, for example: capitalization issue in 'Limited'
in "Zambia is a country where menstrual poverty is a prevalent issue, exacerbated by social
and cultural taboos surrounding menstruation [10,11], Limited access to menstrual hygiene
management". Also, "menstruation" seems to be capitalized in the middle of some sentences
B) The font size seems to change between 11 and 12, which I assume won't be an issue in the
editorial phase
C) I still believe that the conclusion could be more concise and focused on your finding, instead
of a summary of the discussion
Title: Evaluation of One Step Nucleic Acid Amplification for detection of lymph node
metastases compared to histopathological ultrastaging in women with endometrial cancer: A
protocol for a diagnostic accuracy study
Version: 2 Date: 30 Jul 2023
Reviewer:  Peter Hillemanns
Reviewer's report:
The authors present a manuscript for a multicentre European, prospective trial evaluating the
diagnostic accuracy of One Step Nucleic Acid Amplification (OSNA) compared to sentinel
lymph nodes histopathological ultrastaging in endometrial cancer patients which has started
already in 2020. In their discussion, the authors reflect on four studies assessing OSNA in
patients with endometrial cancer published up to the year 2020. However, at least 4 further
studies have been published up to July 2023 listed in PubMed which examined the OSNA assay
with conventional histopathological examination including ultrastaging. It makes sense to reflect
the recent results and include them in the discussion section.
OSNA has been in introduced for breast, colorectal, and gastric cancer patients as whole lymph
node CK19 mRNA analysis. The current approach in the actual studies use every second slice
for OSNA (the other for ultrastaging). How does this approach effect the accuracy between these
two methods?
For the introduction of OSNA into routine, a multicentre study with sufficiently large cohort
of patients is crucial leading to statistically significant results. You state that you will achieve
sufficient statistical power for your primary endpoint with a cohort of 300 patients and 60
positive LNs to be expected. Please, mention your endpoint(s) and the exact calculations for
your statistical analysis based upon a non-inferiority analysis or other.
Prof. Dr. Peter Hillemanns, Dept. of Ob Gyn, Hannover Medical School, Germany
Title: Evaluation of One Step Nucleic Acid Amplification for detection of lymph node
metastases compared to histopathological ultrastaging in women with endometrial cancer: A
protocol for a diagnostic accuracy study
Version: 2 Date: 16 Sep 2023
Reviewer:  Basilio Pecorino
Reviewer's report:
The submitted protocol takes into consideration OSNA method to detect lymph nodes metastases
in endometrial cancer.
Methods are extensively explained and the manuscript is adequate for publication.
My suggestion is to introduce the issue about the new endometrial figo staging 2023 (DOI:
10.1002/ijgo.14923) and its relationship with IHC and metastatic nodes.
Thanks for the opportunity yo review this manuscript and I would like to receive the revised
version for the final evaluation.
Title: Association between the C-reactive protein-triglyceride–glucose index and
endometriosis: a cross-sectional study using data from the National Health and Nutrition
Examination Survey, 1996-2006
Version: 0 Date: 21 Nov 2024
Reviewer:  Yigit Cakiroglu
Reviewer's report:
General comments:
The manuscript has aimed to investigate the associationin between CTI and endometriosis. In
this study, the authors have the data in a total of 2235 women through National Health and
Nutrition Examination Survey.
Abstract:
The abstract describes the short-summarized content of the article.
Background:
Information about endometriosis, CTI, probable association in between CTI and endometriosis
have been given in the introdcution section. Aim has been defined in this section.
Materials and Methods
Design of the study, study population, diagnosis of endometriosis, measurement of the CTI,
covariables, and statistical analysis have been defined in this section.
-How would the authors comment on the diagnosis of endometriosis with a questionnaire-
based survey? Should there be more strict criteria for the diagnosis (Laparoscopy?pathologic
confirmation?). This should be clarified since it is the main limiting factor for the design of the
study.
Results
The result section contains findings and observations in regards of the analysis.
- Would the authors also please analyse the association in patients with “endometriosis” with
the diagnosis of infertility and demonstrate on Table-1?
Discussion
The discussion section states the importance and significance of the findings.
References:
The references section contains appropriate and number of references.
Tables:
Tables are demonstrable and well-designed.
Figures:
Figures are illustrative.
Title: Association between the C-reactive protein-triglyceride–glucose index and
endometriosis: a cross-sectional study using data from the National Health and Nutrition
Examination Survey, 1996-2006
Version: 0 Date: 24 Nov 2024
Reviewer:  Samaneh Rokhgireh
Reviewer's report:
Dear Authors
Thanks for your interesting research. Since Endometriosis and its consequences involve many
patients of reproductive age, you selected a valuable topic.
1- In the introduction, it is better to discuss more concisely the relation between Endometriosis
and Inflammatory state.
2-  Mention the type of study in the title and Method part.
3-How did you include participants in your study? Please clarify the inclusion and exclusion
criteria.
4-What were the diagnostic criteria of Endometriosis? Did All endometriosis patients undergo
laparoscopy?
5-Did you exclude patients with a history of dyslipidemia or diabetes in non-endometriosis
group?
6- How did you rule out endometriosis in the control group? Did you do sonography or take
history? many patients with endometriosis are asymptomatic
7-Please add titles for table and figures.
Title: Association between the C-reactive protein-triglyceride–glucose index and
endometriosis: a cross-sectional study using data from the National Health and Nutrition
Examination Survey, 1996-2006
Version: 0 Date: 27 Nov 2024
Reviewer's report:
Overall the manuscript is interesting and brings up further evidence on the role of inflammation
in endometriosis.
The main limitation of the  manuscript is the English language that requires extensive revisions.