Reviewer ’s report  
 
Title:  Gender and  thrombolysis therapy in stroke patients with incidence dyslipidemia  
 
Version: 1 Date: 03 Oct 2018 
 
Reviewer:  Marie Hélène  Bouvier -Colle  
 
Reviewer’s report:  
 
In this paper the question the authors wanted to clarify is how dyslipidemia may interfer with the 
usual risk factors for exclusion from the thrombolysis therapy, knowing that women are more 
often exluded than men.  
 
The 3 multifactorial ana lyses show that women are more excluded from the treatment than men 
even though carotid artery stenosis and previous stroke are important risk factors for both. On the 
other hand, NIH stroke scale is for both a risk factor for inclusion to the thrombolysis  therapy.  
 
Two other factors differentiate men and women for inclusion, one is clinical, antiplatelet 
medication for men and antihypertensive medication for women, and last but not least age for 
women.  
 
I see an important weakness in the demonstration. The  studied population has been selected 
retrospectively ; so we cannot ignored that selection bias had been present probably in the acute 
ischemic stoke population and that this selection bias was associated with gender.  
 
The scientific approach would be imp roved by two aspects ; firstly, prospective selection of 
patients and not a retrospective study in a single institution, and secondly,  analysis by stratified 
population of men and women  by age. I want to say to analyse the different risk factors 
includin g sex among the stroke patients with dyslipidemia being at the same age.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
No 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in you r comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the qual ity of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
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