JerMa88/BMC_Womens_Health_Peer_Reviews huggingface dataset:
Title: Quality of life and its associated factors among women with pelvic organ prolapse who
attend gynecology clinics Southern Ethiopia 2022
Version: 3 Date: 21 Feb 2024
Reviewer's report:
I read with great interest the Manuscript titled “Quality of life and its associated factors among
women with pelvic organ prolapse who attend gynecology clinics Southern Ethiopia 2022 “.  In
my opinion, this topic analyzed is interesting enough to attract readers’ attention.
Although the manuscript can be considered already of good quality, I would suggest the
following recommendations
- I suggest a round of language revision, in order to correct few typos and improve readability.
- The authors could extend and improved the discussion by evaluating and citing current
evidence about treatment with native tissue repair also for posterior compartment prolapse. (In
particular, I suggest this article to get deeper in the topic PMID: 28786873)
- It would be interesting to discuss about recent evidence of one of the most frequent symptoms
of this pathology and possible therapeutic strategies. I would be glad if the authors discuss this
important point, referring to PMID: 32744453
Because of these reasons, the article should be revised and completed. Considering all these
points, I think it could be of interest to the readers and, in my opinion, it deserves the priority
to be published after minor revisions.
Title: Quality of life and its associated factors among women with pelvic organ prolapse who
attend gynecology clinics Southern Ethiopia 2022
Version: 7 Date: 17 Mar 2024
Reviewer's report:
Thank you for going through the manuscript and the reviewers' points
In my honest opinion, the authors have responded satisfactorily to the reviewers’ criticisms.
The manuscript is well written and falls within the aim of this Journal.
Title: Quality of life and its associated factors among women with pelvic organ prolapse who
attend gynecology clinics Southern Ethiopia 2022
Version: 7 Date: 10 Apr 2024
Reviewer's report:
Generally the issue you attempted to is sensitive and a real public health problem in Ethiopia.
However, there are a number errors including language error, which  is significant, coherence
of ideas, ambiguous measurements including the outcome measurement, inconsistencies in the
use of terminologies, for instance bivariate vs binary, and the journal requirements have to be
clearly examined  etc. The whole manuscript requires serious revision to reach on a position for
making decision to accept or reject.
Title: A Scoping Review on the Nature and Impact of Gender Based Violence on Women
Primary Producers.
Version: 2 Date: 01 Mar 2024
Reviewer's report:
The scoping review paper demonstrates a well-structured and well-executed process for
identifying, reviewing, and presenting findings. The review notably identifies the underreporting
of Gender-Based Violence (GBV) as a significant issue, yet it falls short of suggesting strategies
for improvement. The discussions and conclusions could critically reflect on what Low- and
Middle-Income Countries (LMICs) can glean or learn from High-Income Countries (HICs)
regarding GBV underreporting.
Title: A Scoping Review on the Nature and Impact of Gender Based Violence on Women
Primary Producers.
Version: 2 Date: 02 May 2024
Reviewer's report:
PG. 9  THERE WAS A STATEMENT REFERRING TO INCLUSION AND EXCLUSION
CRITERIA  THAT WAS SET BY THE AUTHORS. UNLIKE THE INCLUSION CRITERIA,
THE  EXCLUSION  WAS NOT CLEARLY STATED.
PG. 18 Several studies discussed how high levels of alcohol consumption contributed to an
environment of coercion, control, and physical harm. IT  WAS HOWEVER NOT CLEAR
WHETHER THE AUTHORS WERE REFERRING TO HIGH LEVELS OF ALCOHOL
CONSUMPTION AMONG MALES OR FEMALES OR BOTH.
PG. 22  LINE 13 'was noted by several authors (18, 55)'. ONCE YOU DECLARE THAT A
PARTICULAR FINDING WAS NOTED BY  SEVERAL AUTHORS, READERS MAY BE
EXPECTING MORE THAN TWO  CITATIONS
Title: The coagulation status in women of endometriosis with stage IV
Version: 3 Date: 10 Mar 2024
Reviewer's report:
In my honest opinion, the topic is interesting enough to attract the readers' attention.
Methodology is accurate and tables and figures are clear.
Nevertheless, I would suggest taking into account the following minor recommendations:
- I suggest another round of language revision, in order to improve readability
- In my opinion, a discussion section should be included following this ideal structure: main
findings of the study, strengths and limitations of the study, comparisons with the literature and
future direction
- The  strengths of the study should be better specified in brief
- I find it interesting to include a reference on the impact of endometriosis on women's lives,
referring to PMID: 32610665
Title: The coagulation status in women of endometriosis with stage IV
Version: 3 Date: 29 Mar 2024
Reviewer's report:
This retrospective case-control study explored the correlations between inflammatory markers
and coagulation factors and the diagnostic value of these parameters, in endometriosis with
stage IV, compared with the control group. The author found that inflammatory factors, and
neutrophil-to-lymphocyte ratio (NLR) showed a significant correlation with APTT or FIB in
endometriosis with stage IV.  The manuscript is interesting because it explored the correlation
between inflammatory factors and coagulation factors.
1. As the author mentioned in the patients’ characteristic part of the result about the comparison
of the size of the ovarian cyst between the endometriosis and control groups in Table 1.
- No data about this comparison is shown in Table 1. Moreover, the inclusion criteria for the
control group were leiomyoma, tubal pathology, and ovarian benign cysts, therefore, some
patients in the control group might not have ovarian cysts. Did everyone in the control group
have an ovarian cyst?
2. The conclusion in the abstract showed repeated sentences. “We found that inflammatory
factors showed significant correlation with APTT or FIB in endometriosis with stage IV.
Moreover, we found that inflammatory factors showed significant correlation with APTT or FIB
in endometriosis with stage IV.”
3. The inclusion method for participants in the Endometriosis group is not mentioned in the
manuscript. How to avoid the selection bias.
4. The control group was patients with surgical diagnoses of uterine leiomyomas, tubal
pathology, and ovarian benign cysts.  Is there any data showing that no change in inflammatory
and coagulation factors in these participants?
5. The participants’ menstrual cycle phase in the Endometriosis group were both proliferative
and secretory phases. No analysis according to each menstrual cycle. The menstrual cycle phase
may affect the inflammatory and bleeding factors.
6. No sample size calculation was demonstrated in the manuscript
Title: The coagulation status in women of endometriosis with stage IV
Version: 4 Date: 09 Jun 2024
Reviewer:  Areepan Sophonsritsuk
Reviewer's report:
This retrospective case-control study explored the correlations between inflammatory
markers and coagulation factors and the diagnostic value of these parameters, in
endometriosis with stage IV, compared with the control group. The author found that
inflammatory factors, and neutrophil-to-lymphocyte ratio (NLR) showed a significant
correlation with APTT or FIB in endometriosis with stage IV.
The author went through the reviewer's suggestion and made the corrections. However there
were some points that the author should do better.
1. The manuscript was reported that APTT in endometriosis was shorter than in controls.
However, in Fig 1a, it seem that the  APTT from controls group  was shorter than the other.
Could the author re-check the data?
2. There were many grammar errors, eg. 1. In line 208 " Both hormonal and surgical therapy ...."
2. line 225   "CA 125 and CA 199 often showed...."   etc.
Please let native English have a look.
Title: Prediction of Precancerous Cervical Cancer Lesions Among Women Living with HIV
(WLHIV) On Antiretroviral Therapy (ART) in Uganda: A Comparison of Supervised Machine
Learning Algorithms
Version: 2 Date: 15 Feb 2024
Reviewer's report:
The paper is well written particularly from the application domain perspective but it can benefit
from some slight improvements as indicated below;
1. "A multivariate binary logistic regression and recursive feature elimination with random forest
(RFERF) were used to identify the best predictors". I suggest that the Authors  utilize the six
machine learning models to  identify the best predictors. It could be an added significance to
the paper.
2. What was the rationale for the 6 models? e.g. Why not add Support Vector Machines etc
3. The random forest is an ensemble of Decision trees and hence would definitely lead to similar
concussions.  I would suggest that you adopt only one of the two instead of both.
4. How did you deal with the data imbalancedness?
Title: Prediction of Precancerous Cervical Cancer Lesions Among Women Living with HIV
(WLHIV) On Antiretroviral Therapy (ART) in Uganda: A Comparison of Supervised Machine
Learning Algorithms
Version: 4 Date: 10 May 2024
Reviewer:  Patrick Musonda
Reviewer's report:
At this stage, it looks like the paper has already been reviewed by another reviewer. The
manuscript had track changes. I think the paper is very good and accurate.
Title: Prediction of Precancerous Cervical Cancer Lesions Among Women Living with HIV
(WLHIV) On Antiretroviral Therapy (ART) in Uganda: A Comparison of Supervised Machine
Learning Algorithms
Version: 4 Date: 19 May 2024
Reviewer's report:
Thank you for inviting me to review the paper "Prediction of Precancerous Cervical Cancer
Lesions Among Women Living with HIV on Antiretroviral Therapy in Uganda: A Comparison
of Supervised Machine Learning Algorithms."
The authors address an important issue at the intersection of HPV and HIV, as women living
with HIV are disproportionately affected. I have a few suggestions that can help them improve
the context and readability of the paper.
Major concerns:
1. Sample size and power calculations: The manuscript did not mention sample size and power
calculations.
2. People-first language: Throughout the manuscript, consider revising phrases like "HIV
infection," "infected with HIV," or "diseased" in favor of "diagnosed with HIV" or "living with
HIV" (lines 58, 88, and 185). This promotes people-first language and avoids stigmatizing terms.
3. High-performance tests for cervical cancer: Lines 68 and 69 mention VIA and Pap smear
as screening methods. While these are useful, HPV DNA testing and liquid-based cytology are
currently considered high-performance tests for cervical cancer (CC).
4. Cost-effectiveness of HPV testing: Line 72 references VIA as cost-effective compared to
others. However, the ASPIRE trial in Kampala demonstrated the cost-effectiveness of HPV
DNA testing. You could revise this section to acknowledge VIA as the most commonly used
method due to factors beyond cost-effectiveness.
5. Future studies: Line 81 seems contradictory to your earlier suggestion for future studies in
those without HIV. Consider revising for clarity.
6. Viral load cutoff: Line 108 mentions detectable vs. not yet different viral load quantities
(<1000, <400, <40(machine limits) have been used in Uganda as a cut-off. If possible, specify
the exact cutoff used in the study for "undetectable" viral load.
Minor grammatical errors: I have highlighted minor grammatical errors in complex sentences
and articles throughout the manuscript. My suggested revisions are in tracked change.
This is a valuable study, I hope these suggestions will strengthen the authors' work.
Title: Relationships between nine neuropsychiatric disorders and cervical cancer: Insights from
genetics, causality and shared gene expression patterns
Version: 0 Date: 27 Feb 2024
Reviewer's report:
Thank you for the opportunity to read and comment on this comprehensive study. I have a few
comments that might be helpful to improve the work.
1. As I understand the research interest is about mental disorders and risk of cervical cancer, but
then in phase 2 there is also progression/prognosis? These are two separate research questions.
I think the latter can be removed given the already extensive scope of the manuscript.
2. In phase 1 analysis, were Discovery stage and replication stage both sourced from UKB? Is
that correct practice?
3. The estimated heritability reported in this study appeared to be much lower than the previously
reported estimates for many mental disorders. Have the authors compared with other studies?
What could be the possible reasons for the differences?
4. The authors should discuss strengths and limitations of the study.
Title: Relationships between nine neuropsychiatric disorders and cervical cancer: Insights from
genetics, causality and shared gene expression patterns
Version: 2 Date: 13 May 2024
Reviewer's report:
I thank the authors for the detailed reply. However I find there is still some room for clarification.
1. Regarding discovery stage and replication stage, it is still not entirely clear to me what was
done basically?
2. The authors mentioned 5 sources of GWAS summary statistics but only 3 were included in
the flow chart. Please be clear and consistent.
3. Parkinson's disease Alzheimer's disease have organic causes and should not be referred to as
mental disorders.
4. There were several typos in Figure 1: ”biobank”,“mental”, ”correlation”, ”six tests”,
”alcohol”, ”cervical”,”annotation”. Please double check it.
5. To help navigate the changes, please include the changes to the manuscript next to the response
of each comment. Currently it is hard/impossible to find them. The line numbers provided were
not correct.
6. The writing will benefit from proofreading by a professional.
Title: Relationships between nine neuropsychiatric disorders and cervical cancer: Insights from
genetics, causality and shared gene expression patterns
Version: 2 Date: 12 Jun 2024
Reviewer:  Rafael Tabarés-Seisdedos
Reviewer's report:
I see this new version as more solid. The correlations used to justify a global analysis of genes
related to both diseases seem very clear to me with the lists of genes they have.
The information in the summary statistics is accessible. The ldsc method is better documented.
They have also changed some of the conclusions in the discussion section, and it seems the
conclusion is clearer now.
In summary, I find this manuscript very useful for visualizing the entire pipeline, especially how
the tests overlap and how to extract significant results for the next step. The methods presented
are well justified, explained, and referenced.
Title: Bidirectional causality between the levels of blood lipids and endometriosis: a two-sample
Mendelian randomization study
Version: 0 Date: 18 Mar 2024
Reviewer's report:
The aim of this study was to examine bidirectional causality between the levels of blood lipids
and the risk of endometriosis using publicly available genome-wide association study (GWAS)
summary statistics.
Authors reported that blood lipids, namely HDL and TG, may play an important role in the
development and progression of endometriosis, but endometriosis does not lead to dyslipidemia.
I have the following comments for the Authors:
• Please extensively revise your English and check for typos and tense mistakes.
• Discussion: This study does not stratify the analysis based on disease severity, location of
lesions, or other relevant clinical factors, which could affect the observed associations between
lipid levels and endometriosis risk.
• Discussion: While the study suggests potential implications for the management of
endometriosis, such as dietary modifications or lipid-lowering medications, the clinical utility of
these interventions requires further validation through prospective clinical trials. Additionally,
the impact of modifying lipid levels on endometriosis outcomes needs to be carefully evaluated.
Title: Bidirectional causality between the levels of blood lipids and endometriosis: a two-sample
Mendelian randomization study
Version: 0 Date: 06 May 2024
Reviewer's report:
Dear Authors,
I read you article investigating the association between endometriosis and lipid blood levels
using MR analysis.
It is an interesting aspect of the disease currently not well established, as several comorbidity
aspects of endometriosis patients are still under investigation.
However, I suggest some amendments to improve the quality of the manuscript, as follows.
1- a minor English revision is needed.
2- Intro: "Typical symptoms of EMs include dysmenorrhea, chronic pelvic pain, menstrual
abnormalities, and even infertility. etc". Remove "etc.". You may also list the risk of central
sensitization, as it seems to play a major role and make it difficult to treat these kind of patients
(https://doi.org/10.1016/j.jmig.2022.10.007).
3- "The incidence of EMs reaches 6%-10% of the female population". This sentence is too
generic. May be confounding. Please specify that the disease affects 6-10% of fertile patients.
4- Material and Methods section: cite clearly the aims of the study in a dedicated section.
5- Material and Methods section: include a section reporting the study design
6- Material and Methods section: did you need an IRB approval for this study?
7- Result section must be shortened. It is too redundant. It should focus on the main findings
and rely on tables and figures to make the results more instant.
8- Discussion section: I would discuss a little about the relevant clinical implications arising
from your findings. Most of all I would highlight the need for early diagnosis of endometriosis
as this may help healthcare professionals in having a multimodal approach to the disease,
considering also the related systemic comorbidities related to the disease such as dyslipidemia
and cardiovascular diseases (reference: https://doi.org/10.3390/jcm13020550). I would also
discuss the need for a wider view on contraceptive prescription in endometriosis patients
due to potential lipid higher levels (https://doi.org/10.1186/s12905-023-02703-7, https://
doi.org/10.1007/s00404-023-07125-2).
Title: Sexual and Reproductive Health in young women with ADHD from the view of Health
Care Professionals
Version: 1 Date: 01 Mar 2024
Reviewer's report:
This is an important and novel study looking at the perceptions of HCPs in multiple clinics
in Sweden responding to the needs of young women with ADHD, with a specific focus
on their sexual and reproductive health. The nature of often undiagnosed AHDH in young
women is highlighted as are the higher rates of risky sexual behaviour. What is missing from
the exploration for further context is a more detailed consideration of the gendered societal
norms experienced by young women and perhaps even more so by women with ADHD.
While mentioned (expectations), the findings from this study have the potential to advance
the discourse around the complexities of developing interventions to address the dynamic
relationship between managing the symptoms of ADHD (which are also socially influenced)
in addition to the natural, and healthy development of a young woman's sexuality and sexual
identity (which is also socially conditioned). These findings are important and could make a
valuable contribution to this field with some additional improvements. Well done, and I hope
you find my comments helpful.
Title: Sexual and Reproductive Health in young women with ADHD from the view of Health
Care Professionals
Version: 2 Date: 19 Jun 2024
Reviewer:  B. Helsing
Reviewer's report:
In the revised manuscript the concerns about how the aim and research object is elaborated
and analysed in the article are clarified. To ensure that text, analysis and interpretation answers
the aim of hcp’s perceptions and experiences and not opinions on women’s experience of SHR
per se has been rephrased in several places. Especially the additions made by the authors in
the discussion section of the article, where the subject of the study now has a more in-depth
and problematized content, strengthens the manuscript in a significant way. Hopefully, the
discussion the authors initiate in the article can continue among HCPs in their clinical work with
young women diagnosed with ADHD.
Title: Clinical Efficacy and Safety of Transvaginal Natural Orifice Transluminal Endoscopic
Surgery for Benign Adnexal Disease: A Prospective Trial
Version: 1 Date: 10 May 2024
Reviewer:  Marco la Verde
Reviewer's report:
Dear Authors
The article "Clinical Efficacy and Safety of Transvaginal Natural Orifice Transluminal
Endoscopic Surgery for Benign Adnexal Disease: A Prospective Trial" has been read. It is an
interesting paper that interests vNOTES and gives promising insight regarding the applications
of vNOTES in the treatment of benign adnexal diseases. Below are some specific suggestions
and observations to further improve the manuscript.
1) Title and Abstract
The title should reflect the purpose and methods of the study. You might want to include the key
findings in the abstract: the non-inferiority of the vNOTES versus conventional laparoscopy.
"Clinical Efficacy and Safety of"  is not necessary.
2) abstract result is not clear. The authors should report the number of patients included in each
grouop.
3) Introduction: This section presents information on ovarian cysts and the novelty of the topic,
the vNOTES.
The authors should support the following sentence in line 45, citinig novel article: https://
doi.org/10.1007/s13304-022-01248-y
4) Results
The results section includes a comparison of the data of the vNOTES and CL.
Perhaps the results should be summarized so that the most important differences become more
transparent.
5) Discussion:
The findings are discussed in relation to the existing literature, therefore, putting them into
perspective.
Describe the clinical implications of reducing postoperative pain and recovery. What are the
implications of this on the outcome or the patient's preferences?
Overall, this article is insightful regarding vNOTES and adds to the existing literature through
these refinements alone.
best regards