Reviewer’s report
Title: 
Granulomatous Cheilitis of Miescher: A rare entity
Version: 
0 
Date: 
11 Nov 2022
Reviewer's report:
PEER REVIEWER ASSESSMENTS: 
RELEVANCE - Does this case report make a contribution to medical
knowledge, have educational value, or highlight the need for a change in clinical
practice or diagnostic/prognostic approaches? 
Yes, this report contributes to medical knowledge
CASE DESCRIPTION - Are the details of the case sufficiently well described to
understand the patient's symptoms and course of treatment? 
No - there are major issues
DIAGNOSIS/INTERPRETATION - Based on the facts presented, are the
diagnosis, interpretation, and course of treatment medically sound?
Yes, the work described is medically sound
DISCUSSION OF THE CASE - Does the discussion appropriately analyse the
importance of the findings and their relevance to future understanding of disease
processes, diagnosis or treatment? Has an adequate literature review pertinent to
the case been included?
No - there are major issues
OVERALL MANUSCRIPT POTENTIAL - Could an appropriately REVISED
version of this work represent a technically sound contribution?
Maybe - with major revisions
PEER REVIEWER COMMENTS: 
GENERAL COMMENTS: The case described here is rare but not uncommon.
The case description and biopsy findings match the diagnosis. 
A few
differentials need to be ruled out . Eg crohn s disease, 
ANCA vasculitis,
ulcerative colitis, 
IGE mediated anaphylaxis etc... a proper discussion on
approach to differentials is required. 
More discussion on melkersson. Rosenthal
syndrome is required
REQUESTED REVISIONS: 
Biopsy pathology slides need to be better. 
More discussion 
on melkersson Rosenthal syndrome is required. 
A table with all the published cases with similar presentations and the unique
features of each would make the case report better. 
A proper clinical description on approach to evaluation and confirmation of
diagnosis of a patient with lip swelling needs to be done. 
A description about
ulcerative colitis, 
crohn disease, 
ANCA vasculitis, 
IGG4 DISEASE and IgE
mediated dermatopathies also need to be written in a better manner
ADDITIONAL REQUESTS/SUGGESTIONS: 
None
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