Reviewer ’s report  
 
Title: Performance of OncoE6 Cervical Test with collection methods enabling self -sampling  
 
Version: 1 Date: 09 Apr 2018  
 
Reviewer: Annarosa Del Mistro  
 
Reviewer's report:  
 
The revised version of the manuscript provides answers to all bu t one of my questions, i.e. the 
description of the single nucleotide mutation of the sample #5 has not been reported; indeed, as 
recommended in lines 261 -262, this information is needed to interrogate for this mutation in 
future analyses of discrepant Onco E6 results.  
An additional suggestion is to modify lines 111 -112 as follows ...18, and we tested the different 
sampling methods with regard to "the OncoE6 Test, comparing the results to the molecular HPV 
genotyping performed on the cytobrush samples".  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the autho rs. 
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an addi tional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
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1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any wa y gain or lose financially from the publication of this  
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2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to al l of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
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