Reviewer’s report
Title: 
The association between endometriosis and risk of endometrial cancer and
breast cancer: A meta-analysis.
Version: 
0 
Date: 
03 Mar 2022
Reviewer: 
Ibrahim A.
Reviewer's report:
Dear Respectable Editor 
I am grateful to give me the opportunity to review the article entitled (The
association between endometriosis and endometrial cancer risk and breast
cancer: a meta-analysis).
The meta-analysis designed to identify the differences in risk of endometrial
cancer and breast cancer between endometriosis and women who are not
endometriosis. 
Authors searched the PubMed, EMBASE, Cochrane library, and four Chinese
databases to identify relevant studies published online between January 2011 and
March 2021. 
Authors found that data from large cohort and case-control studies indicate that
women with endometriosis had both increased risk of endometrial cancer [RR,
1.662; 95%CI, (1.148-2.407)] and breast cancer [RR,1.082; 95%CI, (1.001-
1.169)]. 
Authors concluded that endometriosis could increase the risk of endometrial
cancer and breast cancer, women with endometriosis are suggested to routine
screening in the long-term management.
The authors used a structured abstract and informative clear title. In the
introduction section, the authors explained why their study was designed (several
studies have clearly shown that endometriosis is the risk factor of ovary cancer,
but the impact on endometrial cancer and breast cancer is still controversial). 
In the methodology section, the authors mentioned the data collection for their
meta-analysis, selection criteria and exclusion criteria, data extraction, quality
assessment and risk of bias, and the methods of statistical analysis are clear.
The results of meta-analysis are clear. In the discussion section, the authors
compared their findings with other authors findings, they mentioned the
limitations of their meta-analysis and future suggested studies. The authors
reached clear conclusion reflecting their results and they used relevant
references. 
The manuscript discusses an interesting subject and can be accepted for
publication. 
Many thanks 
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes