Reviewer’ s report
Title: Clinical Efficacy of Various Anti-hypertensive Regimens in Hypertensive Women of
Punjab; A Longitudinal Cohort Study
Version: 0Date: 18 Jan 2020
Reviewer's report:
Summary
This study assessed the clinical efficacy of four different anti-hypertensive protocols (NifedipineGITS or Losartan or Losartan +HCTZ or Nifedipine GITS + Losartan + HCTZ) in 300hypertensive women of Punjab during 12 months. Compared to baseline, the maximum reductionin SBP and DBP was observed with combination therapy, N-GITS + LTN + HCT, followed by N-GITS alone.
General comment
Patients' selection and data analysis should be clarified.
Specific commentsAbstract: This section should be re-written.Introduction: This section should be shortened and the aim of the study should be better described.Methods, Study design: Selection of patients and their treatment status at baseline is unclear to me.
In the text you state "…..enrolling hypertensive women on various anti-hypertensive regimens"
and in Figure 1 you report "…randomly allocated in each study cohort". Why the number of
subjects is different in various groups?
Methods, Study population: This section is redundant.Results: Some data are duplicated in the text and Tables/Figures.Results: Please, show blood pressure values at baseline.Results: Figure S2: The distribution of some side effects appears surprising.Results: Text: "Association of Factors ……." and Table 2 and Figure 2: I feel there are some typos.
Indeed, some data reported in the abstract, Text and Table 2 appear conflicting. For example:".. and normal physical activity (OR: 2.16, p=0.01)" and "..low physical activity (OR; 2.79, p=0.001)" and "Physical activity (ref: Low) Normal 2.79 (1.74, 4.50) < 0.01** 2.16 (1.29, 3.62) <0.01**". It is surprising that lower vegetables intake is associated with lower risk of hypertension.Table 2 should be better reported, particularly regarding the reference group. Figure 2 should bebetter explained.
Discussion: This section should be shortened and focused on main findings.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
NoDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statisticsQuality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
Declaration of competing interests
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