Reviewer’s report
Title: 
Novel compound heterozygous mutation in WEE2 is associated with
fertilization failure: case report of an infertile woman and literature review
Version: 
0 
Date: 
07 Oct 2020
Reviewer's report:
The authors tried to investigate the novel variant WEE2 gene which expands the
genetic spectrum of WEE2 gene and contributes to novel approaches to the
genetic diagnosis and counseling of families with infertility. Co-segregation
analysis of WEE2 gene mutation done all family members and these findings
showed mutations are in trans position. 
I think this paper is interesting and novel. However, there are some issues to be
addressed. 
1. In my opinion this paper should be a Case Report article, not Research. 
2. In Table 3, it is recommended that the phenotype of the patients with WEE2
gene mutations should be written in an extra column and explained with a
paragraph in the discussion part. 
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