Title: Impact of Menopausal Status on Cognitive Function in Female Papillary Thyroid
Carcinoma Patients: A Longitudinal Propensity Score Matched Study
Version: 0 Date: 05 Sep 2024
Reviewer:  Phuc Nhon Nguyen
Reviewer's report:
Dear authors,
Thank you for your topic concerning women’s health. I have some comments in constructive
way:
-In introduction, please explain the choice of Papillary Thyroid Carcinoma for type of thyroid
cancer in the present study.
-Please clarify the definition of peri-, pre-, and post-menopausal status.
-I concern the women with a cessation of menstruation within 6-12 consecutive months, the
study followed-up for 6 months. Later, the participants may be referred to postmenopausal
group.
-Please excluded the vaginal bleeding and ultrasound scan since it excluded the uterine
pathologies. Nguyen PN, Nguyen VT. Evaluating Clinical Features in Intracavitary Uterine
Pathologies among Vietnamese Women Presenting with Peri-and Postmenopausal Bleeding:
A Bicentric Observational Descriptive Analysis. J Midlife Health. 2022;13(3):225-232.
doi:10.4103/jmh.jmh_81_22
Nguyen PN, Nguyen VT. Additional value of Doppler ultrasound to B-mode ultrasound in
assessing for uterine intracavitary pathologies among perimenopausal and postmenopausal
bleeding women: a multicentre prospective observational study in Vietnam. J Ultrasound.
2023;26(2):459-469. doi:10.1007/s40477-022-00732-w
-Exclusion criteria should mention pregnancy, hormone replacement therapy.
-Did the study enroll 753 women for questionnaire complete form? The 322 participants were
obtained with histopathological examination? The remaining cases were not type of Papillary
Thyroid Carcinoma and met the exclusion criteria?
-Body mass index, smoking, alcohol consumption should be provided in baseline characteristics.
-Please mention the hypo/hyperthyroidism condition after surgery of thyroid.
-Sample size of the study was not calculated.
-Definition of important variables should be described.
-Cronbach’s alpha should be provided for survey toolkit.
-The limitation is the year old of participants greater than 40. Meanwhile, the menopausal age
is variable among different countries.
Moreover, the study should compare to the group of woman before 40 years-old since
menopausal status impacts usually on mental health.
Mosconi, L., Berti, V., Dyke, J. et al. Menopause impacts human brain structure, connectivity,
energy metabolism, and amyloid-beta deposition. Sci Rep 11, 10867 (2021). https://
doi.org/10.1038/s41598-021-90084-y
Maki PM, Springer G, Anastos K, et al. Cognitive changes during the menopausal transition: a
longitudinal study in women with and without HIV. Menopause. 2021;28(4):360-368. Published
2021 Jan 11. doi:10.1097/GME.0000000000001725
-Menopause and thyroid dysfunction (hyperthyroidism and hypothyroidism) may be
accompanied by similar symptoms. These symptoms include menstrual irregularities, mood
disorders, increased sweating, sleep disturbances, hair loss, and diminished quality of life.
Mintziori G, Veneti S, Poppe K, et al. EMAS position statement: Thyroid disease and
menopause. Maturitas. 2024;185:107991. doi:10.1016/j.maturitas.2024.107991
-In discussion, please compare the present findings with other studies using detailed data and
concise number.
-Figure 5 is blurred. Please increase the quality.
-English editing is required.