JerMa88/BMC_Womens_Health_Peer_Reviews huggingface dataset:
Title: Ovotesticular Disorder of Sex development in a 46 XY  adolescent: A rare case report
with review of the literature
Version: 1 Date: 14 Aug 2023
Reviewer's report:
This is an interesting case report of ovotesticular DSD presenting relatively late in a 15 year
old male.
Comments to the authors:
1. The case report describes a firm right scrotal mass followed by the statement "the testicle was
present but atrophic." Are the authors referring to the right testicle as being atrophic or the left
testis? If referring to the right testis, then please describe the left one. If describing the left testis,
then please specify that the LEFT testicle was present but atrophic.
2. The patient was described as having no previous pathological history, but I would like more
information on his timing of puberty. Was it a normal full male puberty?
3. The clinical examination describes him as having a "female morphotype with marked
gynecomastia" but I would like to see a more descriptive genital examination, including  pubic
hair (Tanner stage), the phallus, its size, whether or not there was hypospadias, etc.
4. The pelvic ultrasound says there was an absence of female genitalia. Could the authors be
more specific? Was there a uterus? Was it atrophic? Was there a fallopian tube(s) ?
5. For the laboratory data, were an LH and FSH done?
6. A right orchiectomy was performed, but nothing is said about the left (atrophic?) testis. Was
it biopsied? Was it a streak gonad?
7. The pathology report states that "there was a juxtaposition of ovarian stroma and seminiferous
tubules." Were  there follicles identified in the ovarian stroma? By definition, ovotesticular DSD
is defined as "presence of ovarian tissue with follicles and testicular tissue with seminiferous
tubules in the same individual ." Without evidence of follicles, it cannot be called ovotesticular
DSD (Witchel and Lee, Ovotesticular DSD, ( True Hermaphroditism), Pediatric Endocrinology
3rd Edition, 2008).  "The ovarian tissue must contain oocytes for the diagnosis; the presence
of only ovarian stroma is not an adequate criterion" (Bouvattier, Chapter 35, Disorders of Sex
Development, Pediatric Urology 2nd Edition, 2010).
I do not recommend publication of this case report as currently written because a lot of important
information is missing. Also, if there were no follicles present in the ovarian stroma, then I don't
think this can be called a case of ovotesticular DSD.
Title: Ovotesticular Disorder of Sex development in a 46 XY  adolescent: A rare case report
with review of the literature
Version: 1 Date: 19 Aug 2023
Reviewer's report:
The manuscript involves an important area of health and delivers a clear and clinically useful
message. However, it needs some minor improvements in terms of clarity, style, and use of
English, while it has a logical construction. The discussion section is explainatory in the context
of published information. The conclusions accurately and clearly explain the main clinical
message. The references are appropriate and current, but need to be more recent.
Title: Ovotesticular Disorder of Sex development in a 46 XY  adolescent: A rare case report
with review of the literature
Version: 1 Date: 24 Aug 2023
Reviewer:  Yamini Jadhav
Reviewer's report:
Minor changes are required in the case report.
Case report section
1) please specify about the status of proband. Proband was brought up as a female or male?
2) Mention about the details of physical examination such as height, weight and body mass
index.
Conclusion section
Please write about all combination tests which are important to diagnose the Ovotesticular
disorder such as chromosomal study, hormone testing, ultrasound, histopathology study,
radiological investigations.
Title: Ovotesticular Disorder of Sex development in a 46 XY  adolescent: A rare case report
with review of the literature
Version: 1 Date: 25 Aug 2023
Reviewer's report:
The title should include " Ovotesticular Disorder of Sex development in a 46 XY  adolescent"
Abstract: The introduction was acceptable. There was a scarcity of information in the case
report in the abstract just as there were in the actual text of the manuscript.  The term
"Disorders/ Differences in Sex developmen (DSD)" should be included in both the abstract and
the manuscript and the keywords.
Introduction: Need to  elaborate on DSD and focus on ovotesticular DSD.
Case report:  Too little information on the case. Should include: more details on the patient-
how was the adolescent raised- as a boy or a girl? any gender dysphoria? How long did he / she
have the scrotal swelling? Any other associated symptoms?  Any relevant past medical / surgical
history? How did the genitalia appear at birth? how  was the pubertal development?  When did
the breast development start? what about the pubic hair / axillary hair / scrotal size and penile
length? Any significant family history?
Examination findings: height and weight of the adolescent? Any facial hair? Adam's apple?
Voice? Breast Tanner stage? Pubic hair - male distribution? Where was the urethra located?
What was the penile length? Was the other scrotum and testes normal?
What were the findings of the pelvic ultrasound- any female structures? uterus? What were the
findings of the ultrasound of the other scrotum and testes? What was the size of the scrotal
swelling? The hormones mentioned in the investigations part should be capitalized.
How was the diagnosis disclosed to the adolescent and parents? Any referrals to the
endocrinologists or psychologists? Which hormones were counselled for the HRT treatment?
The discussion was also deficient and should be expanded- again need to include a paragraph
on DSD then another on Ovotesticular DSD and another on the varying  clinical features and
presentation, investigation findings,  and management. Elaborate on these aspects that were
reported in the different  studies  that the authors mentioned.  Multidisciplinary approach was
mentioned but not elaborated on - which disciplines should be involved.
Conclusion was acceptable.
Title: Ovotesticular Disorder of Sex development in a 46 XY  adolescent: A rare case report
with review of the literature
Version: 3 Date: 29 Sep 2023
Reviewer's report:
The manuscript involves an important area of health and presents a clear and clinically useful
message. However, it needs some minor improvements in terms of clarity, style, and use of
English, while it has a logical construction. The discussion section is explainatory in the context
of published information. The conclusions accurately and clearly explain the main clinical
message. The references are appropriate and current, but need to be more recent.
Title: Residential status and household wealth disparities in modern contraceptives use among
women in Ghana: A cross-sectional analysis
Version: 4 Date: 14 Sep 2023
Reviewer's report:
While the authors have addressed most of my concerns, I feel a few more concerns remain to
be addressed:
Abstract: In lines 44-46, the results on wealth quintiles are still not clearly informative and
should state the “percentage lower” odds or better still present AORs.
Be consistent with the number of decimal places of the confidence intervals – some are three
while others are two.
The citation number 23 for the MICS sample procedure is wrong; that is just another study using
MICS. The correct citation for this is the MICS Reports which can be sourced from the DHS
Program website.
Line 189, why not bring the dependent variable before the independent variables so you can
pluralize the independent variables?
Line 197, the sentence does not sound well. Revise.
Lines 254-258, the results are still not well presented as the percentages remain without
clear information. For instance, either report the respective AORs or state that the odds of
contraceptive use were 17%, 24%, and 25% lower among women of second, middle, and fourth
wealth quintiles, respectively, compared to those of lowest wealth quintiles. Same with the
interaction term results.
Lines 290-310, the discussion on the place of residence findings under the “Place of residence,
wealth quintile, and modern contraceptive use” subsection is still not convincing. I expect
the authors to discuss their main findings on place of residence and support them with the
information provided in Lines 290-295 and then explain why rural residents may be more likely
to use contraception. However, the authors instead discussed the region of residence which is
not one of the key findings and which should have been discussed under the sociodemographic
subsection.
There are a few typos to be corrected: Lines 130, 419, 420
Title: Metabolism-associated molecular classification of cervical cancer
Version: 1 Date: 14 Jun 2023
Reviewer's report:
The authors present an article on the analysis and search for cellular metabolism genes related
to various aspects of CESC through genetic and genomic approaches; finding some of these
genes involved in tumor stages, specific metabolic pathways, gene mutations, microRNAs,
methylation and cell lineages. This is an original and interesting article in the field of cervical
cancer. There are, however, some points that need revision:
1. In the Genomic changes in metabolism-related genes in CESC section of the Results section,
the sentence "three gene pairs KALRN/CUBN, HERC1/CUBN, and KALRN/HERC1..." seems
not to match the one that mentions that "After this analysis, we found that mutations in these
three genes were related to prognosis (Figure 1E)." Verify that the annotations in Figure 1E
match the above sentences.
2. The authors mention in Genomic changes in metabolism-related genes in CESC in the Results
section that "In addition, in the prognostic analysis, the three genes were all related to prognosis
in patients with CESC (Figure 2C)"; however, the third graph in Figure 2C does not match this
sentence (p=0.254). Please verify.
Title: Metabolism-associated molecular classification of cervical cancer
Version: 5 Date: 03 Oct 2023
Reviewer's report:
In response to my comment 1, the authors indicate in red that "After analysis, we found that
mutations in all three genes are related to prognosis (Figure 1E)", however, this sentence still
does no match Figure 1E as in this Figure 1E they are plotting the ABAC8 vs KALRN genes
but not CUBN or HERC1.
In response to my comment 2, the authors indicate in red that "Furthermore, in the prognostic
analysis, all three were found to be related to the prognosis of CESC (Figure 2C)." In that respect
I can say that the sentence is fulfilled for FGA and FGG, however it is not clear to this reviewer
how the authors find a statistical relationship between FGL and probability of survival with a
value of p=0.254 and a CI: 0.71 - 2.91?
Title: Association between Oral contraceptives with lipid profile: Results from Hoveyzeh cohort
study (HCS)
Version: 2 Date: 16 Jul 2023
Reviewer's report:
My specific comments are as follows:
The manuscript must be edited by English native speaker.
What is the contradictory results?
What is the gap of knowledge?
What is explanation of exclusion criteria?
Regarding “10 to 12 before” it means hour?
What was the aim of blood sampling? For measurement of which variables?
The abbreviations of all words should be added.
There is no information about definition of OCP in method.
The result section is not based on the statistical language. Authors just used p-value.
What is the meaning of “well-trained interviewers and multiple levels of supervisors” ? Which
level? What was the criteria of well-trainer?
There is no footnote for tables.
What is the Q1,Q2,Q3,Q4 in table1.
Are there any non-parametric measurements?
There is no information about time of exposure with OCs.
Title: Association between Oral contraceptives with lipid profile: Results from Hoveyzeh cohort
study (HCS)
Version: 2 Date: 30 Jul 2023
Reviewer:  Hur Hassoy
Reviewer's report:
Dear authors,
A well-written manuscript on an important topic. It is acceptable after the following points have
been corrected.
1. What are the dependent and independent variables of the research? They should be added to
the methods section.
2. The use of row percentage for Table 1 will allow easier interpretation of ki-square analyses.
3. It will be easier to understand if the significant p values in Tables 1 and 2 are “bold” or
highlighted with “*”.
4. Presenting the significant p values as highlighted with “*” or "bold" in Tables 3 and 4 and
deleting the p value columns will provide a clearer table.
5. The p values should be removed from the Discussion section.
6. Can suggestions such as encouraging the protection of men in terms of contraception in case
of lipid profile deterioration of women and providing education in this sense be considered? The
protection of women's health is also a matter of gender equality. Strengthening this perspective
a little more will add value to the manuscript.
Regards
Title: Association between Oral contraceptives with lipid profile: Results from Hoveyzeh cohort
study (HCS)
Version: 2 Date: 12 Aug 2023
Reviewer's report:
The article titled " Association between Oral contraceptives with lipid profile: Results from
Hoveyzeh cohort study " was reviewed. While thanking the authors, please consider the
following:
1- Please provide more details on principal component analysis and its weights in the method
section.
2- Variables such as education, age, physical activity, etc. are ordinal. In logistic regression, it
is considered nominally and this has caused long tables and difficult interpretations.
3- In logistic regression tables, the confidence interval is usually reported instead of the p-value.
4- The regression results have been repeated once in the table and again in the text. Report in
table or text alone seems to be sufficient.
Title: The effect of albumin and hemoglobin levels on the prognosis of early-stage cervical
cancer: a prospective, single-center–based cohort study
Version: 4 Date: 05 Jul 2023
Reviewer's report:
To improve the manuscript, the following major issues need to be addressed:
1. The manuscript should include more detailed information on the adjuvant treatment
administered after surgery, as well as the specific cell types involved and the parametrial status.
Additionally, these details should be thoroughly analyzed to enhance the quality of the study.
2. Regarding the LACC Trial, it is important to provide specific details about the type of surgical
procedure employed (abdominal route versus laparoscopic).
3. It is recommended to utilize cox regression analysis to identify and analyze the impact of
albumin and hemoglobin levels on the oncological outcomes of early-stage cervical cancer
patients. This statistical approach will provide a more robust assessment of the variables'
influence.
4. The discussion section of the manuscript requires substantial improvement. It currently lacks
clarity and coherence. Enhancing the overall organization and structure of the discussion will
significantly enhance the manuscript's readability and impact.
Title: The effect of albumin and hemoglobin levels on the prognosis of early-stage cervical
cancer: a prospective, single-center–based cohort study
Version: 4 Date: 10 Sep 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
No - there are major issues
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
No - there are major issues
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Not sure - key details are missing from the manuscript
STATISTICS - Is the use of statistics in the manuscript appropriate?
No - there are issues with the statistics in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are major issues
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Maybe - with major revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The authors evaluate whether hipoalbuminemia or low Hb value
have negative impact on stage I-II cervical cancer. They clearly showed that hypoalbuminemia
and low Hb level were negative prognostic factor for these patients. However, they did not
include other laboratory parameters. In particular, serum creatinin and MCV value. Because, the
cervix cancer could cause renal failure and this can cause both anemia and hypoalbuminemia,
also this patients may have significant vaginal bleeding and related iron deficiency anemia. This
laboratory values were important, because if author want to show tumor induced smoldering
inflammation cause hypoalbuminemia and low albumin level as a negative inflammatory marker
and negative prognostic factor.  They have to discuss and made a differential diagnosis of these
laboratory values to exclude confounding laboratory values .
REQUESTED REVISIONS:
The authors have to include patients clinico-pathological characteristics and disease related
laboratory values. Therefore, they may be freed of potential confounding values and
characteristics which may interfere with albumin and Hb value such as creatinine and MCV.
ADDITIONAL REQUESTS/SUGGESTIONS:
none
Title: The effect of albumin and hemoglobin levels on the prognosis of early-stage cervical
cancer: a prospective, single-center–based cohort study
Version: 5 Date: 14 Oct 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: the authors responded adequately, they added probable confounding
laboratory values like liver and renal functions and showed these parameters are well divided
in two groups ( anemia or/not, hypoalbuminemia or/not).  So there are no difference between
two groups. On the other hand they also showed that hypoalbuminemia and anemia were
significantly correlated with poor prognostic factors (LVSI, Deep stromal invasion).  They also
added multivariate cox-regression analysis.
ADDITIONAL REQUESTS/SUGGESTIONS:
none
Title: Development of a Multi-Level Family Planning Intervention for Couples in Rural
Uganda: Key Findings & Adaptations Made from Community Engaged Research Methods
Version: 3 Date: 26 Jun 2023
Reviewer's report:
This is a well written paper presenting an interesting study.  This account of a participatory,
qualitative approach to develop an evidence-informed intervention is a valuable addition to the
literature.
The authors are encouraged to consider the following points as they revise the manuscript.
Abstract: The Methods state the N for focus group discussions was 26.  Since the unit of analysis
is the group when FGDs are conducted, it would be more accurate to write N=4 for the FGDs.
Methods
p.8  The authors write, “faith-based PNFP facilities, which mainly promote natural/ineffective
methods (i.e., counting days.)”  Consider writing this in a way that does not equate “natural”
methods with “ineffective.”  WHO includes among the modern contraceptive methods fertility
awareness methods like lactational amenorrhea and Standard Days Method, for example. It is
true that these methods are less effective than medical contraceptives, but they are good options
for many women and certainly better than no family planning method at all.
p.11  Was coding done manually or did the analysts use software for qualitative analysis?
p. 11 Please clarify the analysis step described as follows: “Codes that represented thematic
elements were collated….” It might help to say how the data in the form of the transcripts was
treated.  Please also clarify this step: “a final round of coding was conducted to confirm thematic
validity.”  Was another round of coding conducted on the original transcripts or on collated
excerpts?  Once this second round of coding was conducted, how was the analysis completed?
p.11 When the manuals were piloted, please briefly describe what aspects of the intervention that
the investigators were examining, along with how they made these assessments. For example,
the paper says the investigators offered feedback on the delivery. Was that the only matter that
was examined through the small pilot?
p.12 “Table 1 highlights a selection of key community beliefs….” Should this be Table 3?
Figure 1: The conceptual model specifies “linkages to community- and facility-based FP
services” as the health-system intervention activities.  With the discovery that providers need
reinforced capacity to deliver the full range of contraceptive methods—especially LARCS—is
the research team considering an adjustment to the conceptual model?  If so, please mention
that briefly in the discussion.
Title: Factors influencing maternal healthcare utilization in Papua New Guinea: Andersen's
behaviour model
Version: 0 Date: 12 Sep 2023
Reviewer's report:
Thank you for giving me a chance to review this manuscript. There are few comments that
should be addressed by authors as listed below:
1. There is not a for using Andersen’s behaviour model? Why did you choose this model?
2. the exclusion criteria should be written clearly.
3. Please provide more information about Health Survey (PNGDHS).
4. What tool was used to extract the information?