Reviewer’s report
Title: 
CCDC114, DNAI2 and TOP2A  involves in the effects of Tibolone
treatment on postmenopausal endometrium
Version: 
0 
Date: 
13 Jan 2020
Reviewer's report:
From the introduction and abstract it is not clear what the primary focus of this
paper is. It initially seems to be about the molecular mechanism of action of
tibolone in the management of postmenopausal symptoms but there is little in
the body of the text that actually explains this. There is a suggestion that it
causes altered ciliary movement but would like some further expansion on the
significance of this and what it means clinically.
At one point the authors allude to 'disease in postmenopausal women' - does this
mean endometrial disease or postmenopausal symptoms?
The link to chemotherapy drugs also seems out of sorts from the focus of the
paper
Would suggest more clarification
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the
authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you
recommend an additional statistical review?
If an additional statistical review is recommended, please specify what aspects
require further assessment in your comments to the editors.
I recommend additional statistical review
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
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