Reviewer’s report
Title: 
Prevalence of Premature Ovarian Insufficiency and its determinants in
Iranian populations: Tehran Lipid and Glucose study
Version: 
2 
Date: 
21 Sep 2020
Reviewer's report:
Dear Respectable Editor
Thank you to give me the opportunity to review the revised version of the
manuscript entitled (Prevalence of Premature Ovarian Insufficiency and its
determinants in Iranian populations: Tehran Lipid and Glucose study)
The study aimed to estimate the prevalence of POI and assessing the influential
factors.
The study found that the prevalence of POI (menopause age<40 years) and early
menopause (menopause age <45 years) were estimated 3.5% and 24.6%,
respectively. AFT model showed that in comparison to normal weight women,
time to menopause was decreased by -0.09 year (95%CI: -0.27, -0.01, P=0.023)
and -0.03 year (95%CI: -0.05, -0.02, P=0.000) in underweight and overweight
women, respectively. Moreover, time to natural menopause was increased by
0.12 year (95%CI: 0.07 to 0.17, p=0.000) in women used oral contraceptives
(OCPs) for >6 months.
After the authors revision, the manuscript can be accepted for publication
especially after the authors changed their conclusion to reflect their results and
aim of the study.
Regards 
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Is the study design appropriate to answer the research question (including the use
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