JerMa88/BMC_Womens_Health_Peer_Reviews huggingface dataset:
Title: Association between parity and bone mineral density in postmenopausal women
Version: 1 Date: 02 Jan 2022
Reviewer's report:
I commend the authors for their research entitled "Association between parity and bone mineral
density in postmenopausal women". The manuscript is well written and the conclusions are
based on the results.  I would only suggest the following:
(1)  A further drawback of the present study is that the number of twins per pregnancy is
unknown.  Please mention in the Discussion/Limitation section.
(2) Pregnancy could have a substantial effect on hip BMD, which could even result in  proximal
femoral fracture requiring surgical treatment (Ref.: Fokter SK, Vengust V. Displaced subcapital
fracture of the hip in transient osteoporosis of pregnancy. International Orthopaedics 21 (1997):
201-203.). Please elaborate in the Discussion section.
Title: Association between parity and bone mineral density in postmenopausal women
Version: 3 Date: 10 Mar 2022
Reviewer:  Gregor Prša
Reviewer's report:
I would like to thank the authors for changing the article according to my comments.
The possible pathophysiological background of a different impact to the lumbar and femoral
bone is very well described.
The focus of the article is very well put together with a good background description and
discussion development.
Title: Reproductive and postsurgical outcomes of infertile women with deep infiltrating
endometriosis
Version: 1 Date: 06 Dec 2021
Reviewer's report:
I read with great interest the manuscript, which falls within the aim of this Journal. In my honest
opinion, the topic is interesting enough to attract the readers’ attention. Nevertheless, authors
should clarify some points and improve the discussion. Authors should consider the following
recommendations:
- Manuscript should be extensively revised in order to correct many typos and improve style. I
would suggest a native English speaker to correct syntax errors.
- Abstract: Specify the name of the university hospital. Each acronym should also be explained
in the abstract.
- The best way to calculate the fertility index of women with endometriosis has been recognized
as the AMH dosage and antral follicular count (AFC) . Why haven't you used these? Make a
comment.
- The most accurate way to classify DIE nowadays is the ENZIAN classification (PMID:
33483970). Why did you use the r AFS scoring system? It is difficult to find a correlation
between the degree of the disease and the fertility outcome. Make a comment.
- All pregnancy outcomes considered should be specified, whether spontaneous or IVF
pregnancies. Compare your outcomes with literature data (read and cite PMID: 34623489;
PMID: 34096691)
- Table 2: you should remove "with"
- Discussion. You state "DIE surgery improve pain symptoms and quality of life".   Many
interventions have been mentioned in the literature for improving the quality of life of women
with endometriosis (read and cite doi: 10.1186/s10397-021-01096-5) and  many of them also
depend on the energy used in the surgical treatment (read and cite PMID: 34448038). Mention
what you used in nodules excision procedures.
Compare your results with more recent reviews of the literature (PMID: 34008386 PMID:
33687160).
Regarding using the GnrH-a after surgery, specify if it was used in women who spontaneously
got pregnant or those undergoing IVF and compare your data with the literature reviews (PMID:
33020832 PMID: 32800068).
Title: Reproductive and postsurgical outcomes of infertile women with deep infiltrating
endometriosis
Version: 1 Date: 29 Dec 2021
Reviewer:  Pasquale De Franciscis
Reviewer's report:
I read with great interest the Manuscript titled “Reproductive and postsurgical outcomes of
infertile women with deep infiltrating endometriosis”, which falls within the aim of such
a valuable Journal. In my honest opinion, the topic is interesting enough to attract the
readers’ attention. Methodology is accurate and conclusions are supported by the data analysis.
Nevertheless, authors should clarify some minor points among the methodology and results and
improve the discussion citing relevant and novel key articles about the topic.
Title: Prevalence of Dysmenorrhea among Reproductive Age Group in Saudi Women
Version: 3 Date: 20 Aug 2021
Reviewer's report:
I read with great interest the manuscript, which falls within the aim of this Journal. In my honest
opinion, the topic is interesting enough to attract the readers’ attention. Nevertheless, authors
should clarify some points and improve the discussion, as suggested below.
Authors should consider the following recommendations:
- Manuscript should be further revised in order to correct some typos and improve style.
- I would suggest to highlight, at least briefly, that dysmemorrea may be the first symptom of
endometriosis, which should be ruled out promptly (authors may refer to: PMID: 28553145;
PMID: 30074068).
- I recommend to add further details about the effect of acute/chronic pelvic pain and
dysmenorrhea on quality of life and psychological wellbeing (PMID: 31755674; PMID:
27750468).
Title: Prevalence of Dysmenorrhea among Reproductive Age Group in Saudi Women
Version: 3 Date: 16 Nov 2021
Reviewer's report:
Thank you to let me review this interesting manuscript.
The incidence of dysmenorrhea is very high in your sample.   Was the questionnaire submitted
to women who went for a gynecological examination for dysmenorrhea problems? It is not clear
how the patients were recruited. This could explain the high incidence of dysmenorrhea in the
sample.
I think the discussion should be slightly expanded by taking into consideration other references
as well.
minor error : Use in the text irritable bowel syndrome ( IBS) the first time it is used in the text
and not the abbreviation
Title: Prevalence of Dysmenorrhea among Reproductive Age Group in Saudi Women
Version: 3 Date: 17 Nov 2021
Reviewer's report:
I read carefully the paper: " Prevalence of Dysmenorrhea among Reproductive Age Group in
Saudi Women". This is a well written paper with the aim of analysing the prevalence of primary
and secondary dysmenorrhea among Saudi women from reproductive age group.
However, I must underline some aspects:
• I have to report you don’t compare your sample with the total number of women among
the reproductive age in Saudi. So, I think the results can’t be actually considered significative:
they’re representative only of a small part of the sample.
• the aim of this study is to analyse the prevalence of dysmenorrhoea in Saudi, but in truth
secondary objectives are more weighty. Perhaps the primary objective should be revised. How
was the sample size calculated in order to define the prevalence of the disease? This should be
mentioned.
• Line 37: you assert prevalence of dysmenorrhea was high. It should be specified that it is one's
own sample.
• At line 78, you assert for the first time, one of the goals of the study is to determine the
relationship between dysmenorrhea and intake of dairy products. I would indicate that they are
the secondary objectives
• At line 132 you cite inclusion criteria of the study but you’ll never explain what they are.
• The different correlations between dysmenorrhoea and the other variables analysed should be
further detailed.
Title: Evaluation of the association of endometriosis and mammographic breast density, a cross-
sectional study
Version: 2 Date: 04 Dec 2021
Reviewer's report:
I read with great interest the manuscript, which falls within the aim of this Journal. In my honest
opinion, the topic is interesting enough to attract the readers’ attention. Nevertheless, authors
should clarify some points and improve the discussion, as suggested below. Authors should
consider the following recommendations:
- Manuscript should be further revised in order to correct some typos and improve style.
-Introduction part, line 4, reference is missing. I suggest you mention this review (doi: 10.1186/
s10397-021-01096-5)
- Introduction part, from line 9 to 12, this part lacks texture. You should confirm by citing more
papers on this evidence. I would like you to talk about the etiopathogenesis of endometriosis ,
also citing the genetic, epigenetic and metabolomics theories (PMID: 32143537; PMID:
30909768; PMID: 33174185) as well as those of the altered intestinal absorption that can
cause transposition of intestinal microbiota and the inflammation of the peritoneal fluid (PMID:
32401078), highlighting the relationships between endometriosis and the host microbiome
(PMID: 33851803). It would also be helpful to discuss the etiopathogenesis of MBD and
understand if there may be a correlation between the two conditions in addition to the altered
estrogenic state.
- Results: It would help if you also stratified the groups according to the severity of endometriosis
(type? localization? according to rASRM or Enzian score) to understand the correlation with
breast density.
- Discussion: You repeat this sentence "Univariate and multivariate analysis were carried out to
understand the relative importance of potential predictors of MBD". Some of your comments
are to be moved to the results part.
Title: Evaluation of the association of endometriosis and mammographic breast density, a cross-
sectional study
Version: 2 Date: 01 Mar 2022
Reviewer's report:
The researchers have conducted a cross-sectional study to compare breast density among
women who have been diagnosed with endometriosis and those who do not have this diagnosis.
Participants were selected from women attending hospital with cases having been diagnosed via
laparoscopy and controls women who had undergone laparoscopic surgery for other reasons.
The association between breast density and a diagnosis of endometriosis was assessed using
univariable and multivariable regression models. The researchers report that women with
a diagnosis of endometriosis had lower mean breast density even after adjusting for other
variables.
The paper is in the most clearly written however there are several points where greater clarity
is needed. These are described below.
1. The description of how the sample size was derived is not clear, or incorrect
“The estimated sample size was 180 for each group, calculated based on a prevalence of 40%
for high MBD reported in the study of Alipour et al. [7], 95% confidence interval (CI), power
of 80% and precision level of 5%. The final sample size was 360 plus 10 extra cases in the
control group.”
Please provide more details. If the sample size was based on detecting a  difference in the
prevalence of high MBD then what difference was to be detected?
2. Please explain the exclusion criteria – “Women who had undergone mammography less than
one year sooner, those with a history of any type of cancer, positive genetic test for breast cancer
(BRCA1, BRCA2), history of radiotherapy, and history of breast cancer in first degree relatives
were excluded from the study”
3. If women who had a “history of breast cancer in first degree relatives were excluded from the
study” why are there 59 of these women included in Table 1?
4. In table 2 are the means reported the regression coefficients from the regression models? If
so then I would expect the SD reported is actually the standard error. Please correct these and
provide the units for age and BMI and use a more understandable scale (eg 5 years) for age.
5. In table 2 please provide the observed means for each level of the categorical variables (eg
those women who do and do not have a diagnosis of endometriosis) and for categories of age
and BMI.
6. Please provide a flow chart describing the how many women were initially invited, agreed,
had measurements taken etc.
7. Please provide more detail in the text of the Results other than reporting P-values.
Title: Is adjuvant chemotherapy necessary for young women with early-stage epithelial ovarian
cancer who have undergone fertility-sparing surgery?: a multicenter retrospective analysis
Version: 3 Date: 19 Dec 2021
Reviewer:  Ruifang Chen
Reviewer's report:
The present paper investigated the effect of adjuvant chemotherapy on oncologic outcomes after
FSS in young patients with stage I EOC. The full text is logically rigorous, and the data is
handled properly, and it is useful for adjuvant chemotherapy decision-making. This is a very
good article, worthy of publication.
Before publication, there are some details that need to be revised as follows:
1.Line 60. Should ‘recommend’  be ‘recommended’?
2.'P' in P-value is always italicized and capitalized.
3.Line 173. Should ‘Figure S2’  be ‘Figure S1’?
Title: Is adjuvant chemotherapy necessary for young women with early-stage epithelial ovarian
cancer who have undergone fertility-sparing surgery?: a multicenter retrospective analysis
Version: 3 Date: 22 Dec 2021
Reviewer's report:
1.Did patients undergo complete staging surgery after disease recurrence?
2. The rate of stage Ic was higher in chemotherapy group than the observation group. Advanced
stage may affect the recurrence time.This mismatch may cause a decrease in statistical validity.
Title: Discontinuation rates of intrauterine contraception due to unfavourable bleeding: a
systematic review
Version: 0 Date: 05 Jan 2022
Reviewer:  Itziar Salaverria Lete
Reviewer's report:
This article is a systematic review on discontinuation of IUD use related to bleeding pattern.
The objective of the review is to find differences in the discontinuation rate between the LNG-
IUS and the Cu-IUD related to the bleeding pattern of each type of intrauterine devices.
During the analysis of the article, I have had quite a few doubts related, above all, to the type of
studies included. It would have been better and more accurate to use only comparative studies
between both types of IUD.
Another objection is the fact that the bibliographical search began in 2000, curiously the same
year that Mirena was released in many countries. This selection of studies from the year 2000
leaves out of the review many studies carried out with the Cu-IUD prior to that date. It should
not be forgotten that the Cu-IUD was widely used in the 1980s and 1990s.
When I have almost reached the end of the article I have observed in the section of strengths
and weaknesses that the authors discuss these points and relativize their conclusions based on
the limitations described.
Under these conditions, I consider that the article can be published without modifications.
Title: Discontinuation rates of intrauterine contraception due to unfavourable bleeding: a
systematic review
Version: 0 Date: 05 Jan 2022
Reviewer:  Norman D Goldstuck
Reviewer's report:
Abstract:  The Methods section should be expanded a bit to give a one or two line description
of search criteria.
Background: The term LNG-IUSs is used rather than the newer WHO LNG-IUDS. While I
think the former is preferable, we may have to fall in eventually. line 15. Possibly add that
discontinuation rates may be as high as 50%.
line 22. I know studies in Asia were excluded but its interesting that lack of bleeding was a large
discontinuation factor in the WHO 7 year Mirena study some years ago.
Methods: Searches were performed from 2000, but the review was limited to studies from 2010-
why?
Is the raw data available in eg Open Science Framework or similar?
Results; The authors note that 5 publications did not report data according to IUC type.
Anyone who has reviewed records for any reason (especially medico-legal) will not that often
notes say "IUD inserted' Or "copper IUD inserted" or "hormonal IUD inserted".
For all reasons therefore its important to fully document the device being inserted.
The authors use the term "LNG-IUS" as if talking about a homogenous method which it
decidedly is not.  The physical size and especially the reservoir load and the release rate and
serum levels of the 52mg. 19.5mg and 13.5mg are very different. While LNG-IUSs(pleural)
cannot be differentiated, where the term LNG-IUS is used it should be followed by the
dose wherever possible. The different doses have been grouped together in the "rates of
discontinuation section". Bleeding may be due to inhibition of PTEN suppressor activity and
this could vary with LNG dose.
Cu-IUDs are probably much more homogenous so stipulating the minor differences in load is
not so important but for the sake of accuracy the type should be stated where possible if only so
that the interested reader does not have to go back to the references all the time.
Discussion:      Bleeding may be related to genetic factors. Associations of MCM8 rs3761873
and rs16991617 variants with
abnormal uterine bleeding induced by copper intrauterine
device
Yupei Shen, Linfen Xu, Weiqiang Zhu, Zhaofeng Zhang, Junwei Liu, Lifang Jiang, Xiaoli Liu,
Yanyan Mao,
Jianhua Xu, Xiaoqin Yan, Junjie Sun, Fang Liu, Xiumei Xiong, Xiujuan  https://doi.org/10.1111/
jog.15101
Title: Physical activity and health-related quality of life among high-risk women for type 2
diabetes in the early years after pregnancy.
Version: 0 Date: 18 Jan 2022
Reviewer's report:
First of all, I would like to congratulate the authors on their manuscript and thank them for
its development and publication. It is well structured and the information is clearly presented.
However, there are some aspects that would strengthen the quality of the work.
Title: The title leaves some confusion, I would like to focus on the study population: "high-risk
women in the early post-pregnancy...".
Abstract: Good.
Could be improved by concluding that "but no differences were found among women affected
by obesity in..." instead of "but not among women affected by obesity in...".
Keywords: It would be advisable not to include keywords used in the title, it would favour the
search.
Introduction: Good.
Topic well oriented. There are current citations, combined with older citations, making a good
sampling of what is known and what is not.
A paragraph could be included, commenting on what other possibilities can lead women to suffer
from diabetes, in addition to the one cited in this research.
Materials and methods. Good.
Include a sub-section to introduce the participants and include the sample calculation, or
statistical power with the data you have. Or include in limitations.
Better identify inclusion criteria. Exclusion criteria are well defined.
Cite the validation and reliability of the measurement instrument, and whether it is validated in
the language used, and whether it is reliable in that group.
Statistical analysis.
It would be advisable to study normality using the kolgomorov-smirnov test, given the type of
sample. Apply the Bonferroni correction.
What was the source for interpreting the correlations?
Limitations.
Include future directions and practical applications.
Conclusions. Good. Better presented than in the abstract.
In the tables, in the p-values <0.05, indicate the exact p-value, especially when not including
the Bonferroni correction.
It is an interesting study, which fills a gap where there is a lack of knowledge and can contribute
to this gap. I would like to see this research published, including some of the small improvements
mentioned above.
Title: Physical activity and health-related quality of life among high-risk women for type 2
diabetes in the early years after pregnancy.
Version: 4 Date: 28 Feb 2022
Reviewer's report:
The authors have made the appropriate corrections in the article according to the
recommendations of the reviewers. And those suggestions that they have not been able to carry
out have been reasonably justified.
I consider that the article has improved considerably to be able to be accepted.
Title: COMPARISON OF URINARY ADIPONECTIN IN THE PRESENCE OF
METABOLIC SYNDROME IN PERI- AND POSTMENOPAUSAL WOMEN
Version: 1 Date: 26 Oct 2021
Reviewer's report:
The authors should better introduce the relevance of the study by reporting that other
scientific reaserches have been conducted with the aim to assess a good biomarker/screener
for cardiometabolic risk. I think that the authors should cite a recent paper demonstrating that
NAFLD is absolutely relevant in stratifying the cardiometabolic risk (Lancet Gastroenterol
Hepatol. 2021 Nov;6(11):903-913. doi: 10.1016/S2468-1253(21)00308-3  ). This should be
empahasize.
-another important point is that SHBG has been reported to be a good marker for NAFLD in
post-menopausal women (Front Endocrinol (Lausanne). 2021 Mar 29;12:641446. doi: 10.3389/
fendo.2021.641446. eCollection 2021)
- The results should be stratified also according to testosterone level in these patients.
Testosterone decline with ageing and not for menopausal onset (J Clin Endocrinol Metab. 2019
Oct 1;104(10):4660-4666. doi: 10.1210/jc.2019-01603)....therefore the lack of evaluation of
such a important hormone with known effect on adiponectin (Endocrinol Metab Clin North Am.
2020 Jun;49(2):215-228. doi: 10.1016/j.ecl.2020.02.008.) could be one of the reason for the lack
of statstistically significant results in their population
- I woulk like to see the stratificantion of results by using the age-bands more than pre-
menopausal and post-menopausal status. Is adiponecting able to assess the cardiometabolic risk
(MetS) n the different age-bands?
Title: COMPARISON OF URINARY ADIPONECTIN IN THE PRESENCE OF
METABOLIC SYNDROME IN PERI- AND POSTMENOPAUSAL WOMEN
Version: 1 Date: 10 Nov 2021
Reviewer:  Mohd Ashraf Ganie
Reviewer's report:
Manuscript Title: COMPARISON OF URINARY ADIPONECTIN IN THE PRESENCE OF
METABOLIC SYNDROME IN PERI- AND POSTMENOPAUSAL WOMEN.
Author of manuscript:  Patsama Vichinsartvichai, et al
Reviewer: Mohd Ashraf Ganie, MBBS MD DM
The manuscript titled: “COMPARISON OF URINARY ADIPONECTIN IN THE PRESENCE
OF METABOLIC SYNDROME IN PERI- AND POSTMENOPAUSAL WOMEN.”The
manuscript doesn’t provide much novelty. However, if presented properly may provide some
readymade information to the readers. In order to do so the authors need to improve the scientific
content, besides editing by a native English speaker.The point by point concerns to be addressed
before considering it for publication are as follows:.
Comments;
Introduction
1. The author is requested to justify the line number 2 [page no.3]
2. Metabolic syndrome is not discussed properly in the introduction part
3. There is no need of discussing pandemic covid 19 in this section. [line no.19, page no.3]
4. The author is suggested to shed a light on the background of adiponectin  vasoactive peptide.
[line 10,page no.3]
5. Overall English language needs editing.
6. There are numerous typo and syntx errors, please correct
Materials and Methods
1. The author is suggested to mention why age range at least 40 years womens   recruited [page
4 line no.9]
2. The author is suggested to  briefly explain the straw+ 10 stage of reproductive aging [page
4 line no.10]
3. Elaborate the inclusion and exclusion criteria in a proper manner which is not [page 4 line
no.12]
Results
1. The result part is too short which is not justified the author is suggested to elaborate the
association of each and every parameters mentioned in a given tables.
2. The author is suggested to include the insulin(variable) parameter as well because as per
previous litratures  adiponectin has positive correlation with insulin sensitivity
Discussion
1. The results obtained from their studies not discussed here [page no 8 ,line no.13]
2. The refrence is missing [page no 8 ,line no.18]
3. The refrence of line number 20 is missing [page number 8]
4. Studies which are consistent and inconsistent with our results have not been discussed
anywhere in the discussion portion.
5. What was the need of screening urinary adiponectin levels is not mentioned properly.
The studies already worked on evaluated urinary adiponectin levels have not been mentioned
properly.
6..The discussion part lacks the mechanistic explanation and is not reflected with result part.