JerMa88/BMC_Womens_Health_Peer_Reviews huggingface dataset:
Title: Associations of the Healthy Beverage Index (HBI) and the risk of Breast Cancer (BrCa):
A Case–Control Study
Version: 2 Date: 18 Aug 2024
Reviewer's report:
Dear Editor
Thanks for giving me the opportunity to review the manuscript.
The title of the study is novel and interesting, but I highly recommend editing the article once
more because understanding some sections of the article is quite difficult. My comments are as
follows. Title: Please avoid using abbreviations in the title. Since breast cancer is a common
disease in women I think you can omit “women” in title
Abstract:
Method: please mention your sampling method and please define HBI.
Results. At the beginning compare case and control group in term of demographic characteristics
then answer the main research question.
“premenopausal (OR: 0.38; 95 % CI: 0.16-0.92, Pvalue=0.013), and postmenopausal (OR: 0.27;
95 % CI: 0.10-0.78, Pvalue=0.023).”
The above sentence does not make any sense.
Method
“The age and BMI matching was don between two groups was done.” Need to be revised
Results
The first paragraph: please mention the p- value
BrCa and breast cancer and BC have been used throughout the article please be consistent.
Title: Associations of the Healthy Beverage Index (HBI) and the risk of Breast Cancer (BrCa):
A Case–Control Study
Version: 3 Date: 01 Sep 2024
Reviewer's report:
Thank you for your responses, although I did not understand why you wrote p-trend in the table.
Because here the relationship is not in a constant decreasing form, so it is better to remove them
from the table.
Title: Exploring Hormone Replacement Therapy Dynamics Among Menopausal Women in
Kuala Lumpur – A Community Based Survey.
Version: 1 Date: 24 Jul 2024
Reviewer:  Asem Moussa
Reviewer's report:
It is a very informative and comprehensive piece of work  .
Still, a considerable percentage of women did not hear about HRT therapy as an existing
treatment for risky conditions like osteoporosis.
Title: A Case Report on Renal Metastasis as an Unusual Presentation of Choriocarcinoma
Version: 3 Date: 13 Aug 2024
Reviewer's report:
Response for Choriocarcinoma case study
Reviewers Coments
1. Please see the manuscript for attached comments
2. There should be more clarity and chronology in the case presentations. At sompe point, it was
difficult to determine which of the admissions that was being referred to
3. Report medical evidence from her data corresponding to no sign of recurrent illness after 8
months of follow-up
4. Any figure or ultrasound report post treatment?
Title: A Case Report on Renal Metastasis as an Unusual Presentation of Choriocarcinoma
Version: 3 Date: 22 Aug 2024
Reviewer's report:
Dear Authors,
here I list some points to face in order to achieve a  good overall results.
1- Structure and formal part of the article is frankly lacking. Please make sure
your article follows BMC-WH guidelines for authors, especially these related to
case report (https://bmcwomenshealth.biomedcentral.com/submission-guidelines/preparing-
your-manuscript/case-report).
2- CARE checklist should be provided for case reports. Please follow steep-by-step the checklist.
It will lead you during the writing process of this article.
3- A major major English revision is highly recommended. Syntax, language, form, tone should
be revised.
4- Abstract: please provide more details on the Diagnostic flowchart you followed, describe
what you found both during the diagnostic process and the therapy, and so on
5- "Its two main features are good chemotherapeutic sensitivity ". What this sentence mean?
6- "Renal metastasis is rarely discussed in the literature". Why? Please briefly explain.
7- Introduction: please provide more details on the correct diagnostic flowchart that should be
employed for the diagnosis of choriocarcinoma
8- Describe the ultrasonographic appearance of the  ectopic masses
9- How high was beta-HCG?
10- Provide detailed description of pathological examinations.
11- Please discuss differential diagnosis, especially in cases of diseases with similar behaviour
such as extrauterine adenomyoma, a rare though potentially malignant disease with extrauterine
involvement (https://doi.org/10.1002/ijgo.15049)
Title: A Case Report on Renal Metastasis as an Unusual Presentation of Choriocarcinoma
Version: 4 Date: 13 Sep 2024
Reviewer's report:
Thank you very much for the opportunity to review the manuscript.
I read the manuscript with great pleasure.
This case report highlights a rare presentation of choriocarcinoma with renal metastasis, a
highly unusual occurrence for this type of tumor, which typically metastasizes to the lungs,
vagina, liver, and brain. The manuscript effectively documents the clinical course of a 27-
year-old woman who presented with symptoms resembling an ectopic pregnancy, leading to
initial misdiagnosis. The report underscores the importance of considering choriocarcinoma in
reproductive-age women with atypical renal masses and emphasizes the diagnostic challenges
due to its variable presentation. The discussion is well-supported by relevant literature, providing
valuable insights into the diagnosis, treatment, and management of this rare condition. Overall,
the manuscript is well-organized and contributes significantly to the clinical understanding of
choriocarcinoma with uncommon metastatic sites, though minor revisions are recommended to
enhance clarity and the depth of the discussion.
Please define all abbreviations where they first appear in the text (abstract).
I would suggest providing a more in-depth analysis of why the initial diagnosis was missed and
the lessons learned for clinical practice.
Please try to clearly provide strengths of your approach in this case along with limitations.
Title: Malignancy Risk Factors Based on Endometrial Polyp
Version: 1 Date: 21 Aug 2024
Reviewer's report:
The manuscript explores the relationship between endometrial polyps and the risk of
malignancy, focusing on clinical and demographic factors. The study included 203 patients, with
12 cases identified as malignant and 191 as benign. Key findings suggest that elevated fasting
glucose levels, CRP levels, polyp size, and endometrial thickness are significant risk factors for
malignancy. The manuscript is well-organized, with a clear methodology and thorough statistical
analysis. The results highlight the importance of monitoring these risk factors, particularly in
postmenopausal women, to prevent malignant progression.
Strengths are that the study addresses a crucial aspect of gynecological oncology by identifying
predictive factors for malignancy in endometrial polyps;, and the use of ROC analysis to
establish threshold values for malignancy prediction enhances the clinical relevance of the
findings.
It provides actionable insights for clinical practice, but would benefit from expanding the sample
size and further exploring the study’s limitations. In fact, the sample size, particularly the number
of malignant cases, is relatively small, which could impact the generalizability of the findings.
The confidence intervals for some odds ratios are broad, indicating variability that could be
reduced with a larger sample. The manuscript could benefit from a more detailed discussion of
the study’s limitations and suggestions for future research.
It would be advisable to cite these articles:
-DOI: 10.3390/cancers16071315, as it presents a novel approach using deep learning (DL) to
detect and classify endometrial pathologies from hysteroscopic images. The study highlights
the potential of DL models in enhancing diagnostic accuracy, especially when combined with
clinical factors. Despite the preliminary nature of the findings and the modest improvement
in diagnostic performance, the research underscores the importance of integrating artificial
intelligence in gynecological diagnostics, which could be relevant to the discussion of
identifying malignancy risk factors in endometrial polyps.
-DOI: 10.1155/2010/638165, as it provides a comprehensive review of the current challenges
and debates in the treatment of endometrial cancer (EC). It highlights that EC is the most
common malignancy of the female genital tract, with surgery being the cornerstone of treatment.
The study discusses various aspects such as risk factors, including obesity and hormonal
imbalances, diagnostic approaches like hysteroscopy and transvaginal ultrasonography, and
the controversies surrounding the role of lymphadenectomy and radiotherapy in intermediate-
risk cases. Additionally, it explores fertility-sparing treatments and the increasing role of
chemotherapy in advanced stages. The review underscores the need for more research and
clearer guidelines, especially regarding the use of radiotherapy and the management of early-
stage EC with fertility-preserving intentions.
Title: Malignancy Risk Factors Based on Endometrial Polyp
Version: 1 Date: 07 Sep 2024
Reviewer:  Hossam Hassan Aly Hassan El Sokkary
Reviewer's report:
The article objectives are very important but the aim  in abstract should be clear and precise
as it stated that cases group were all malignant but the truth that only 3 cases were malignant
and 9 cases were atypical endometrial hyperplasia which is a premalignant lesion!! This shoud
be corrected and mentioned in result not only in discussion so the comparison was between
premalignant /malignant polyps and benign polyps.
The materials and methods should be written more clearly, I understood that you want to
exclude some common risks factor as age , gravidity, parity etc and concentrate up on other as
endometrial thickness,  polyp size , CRP, etc
So please write it more clearly by mentioning that this common risk factors are excluded and
other are studied (inclusion and exclusion criteria)
In results a d discussion, the article mentioned comparison regarding excluded risks factors
between both groups  why , from the start you include cases with similarities regarding these
risks factors
Please don't comment on excluded risks factors  regarding comparison between both groups in
result and discussion
In result  and discussion ,you mentioned size of polyp in cm which is a measure of lengh not
a size (cubic centimeter is the unit of size)
In discussion you didn't mention any others studies regarding diabetic states  and CRP to
compare the results of those studies and your data please include it
In discord you try to explain the pathogenesis of cancer in relation to diabetes and CRP which
are out of articles aim and explained the developments in cancer in general not in relation to
endometrial cancer
All these points should be corrected before re evaluation
Title: Malignancy Risk Factors Based on Endometrial Polyp
Version: 2 Date: 22 Sep 2024
Reviewer's report:
It provides actionable insights for clinical practice, but would benefit from expanding the sample
size and further exploring the study’s limitations. In fact, the sample size, particularly the number
of malignant cases, is relatively small, which could impact the generalizability of the findings.
The confidence intervals for some odds ratios are broad, indicating variability that could be
reduced with a larger sample. The manuscript could benefit from a more detailed discussion of
the study’s limitations and suggestions for future research.
I suggest to cite these articles:
-DOI: 10.3390/cancers16071315, as it presents a novel approach using deep learning  to detect
and classify endometrial pathologies from hysteroscopic images. The study highlights the
potential of DL models in enhancing diagnostic accuracy, especially when combined with
clinical factors. Despite the preliminary nature of the findings and the modest improvement
in diagnostic performance, the research underscores the importance of integrating artificial
intelligence in gynecological diagnostics, which could be relevant to the discussion of
identifying malignancy risk factors in endometrial polyps.
-DOI: 10.1155/2010/638165, as it provides a comprehensive review of the current challenges
and debates in the treatment of endometrial cancer
Title: Krukenberg tumour in a 46-year-old black African woman with a background of ovarian
fibroma- A case report
Version: 1 Date: 12 Sep 2024
Reviewer's report:
Thank you for giving me the opportunity to review this interesting case report "Krukenberg
tumor in a 46-year-old black African woman with a background of ovarian fibroma".
However, I have some comments and recommendations:
Comments:
Title: - Is appropriate for the content of the article.
Abstract:- Represents a suitable summary of the work.
Case:- The methods and results have been well explained.
Conclusions:- Are justified on the basis of the study.
Recommendations:
References:- Stick to the format of the journal.
General:- Revise language, grammar and syntax.
Title: Krukenberg tumour in a 46-year-old black African woman with a background of ovarian
fibroma- A case report
Version: 1 Date: 14 Sep 2024
Reviewer's report:
Dear Authors
Your article is very well written, but below I wrote some points to improve it:
1. The discussion could benefit from a more structured analysis of how clinicians can avoid
misdiagnosis in such cases. For example, incorporating practical guidelines or steps that
pathologists and clinicians could follow to differentiate between benign and malignant cells
more efficiently could add value to the paper.
2.  The word "case report" is not a keyword in the abstract
3.  Some sections could benefit from clearer sentence structures. For example, in the case
presentation, the sentence “She had no known history of hypertension or diabetes and had no
significant past medical history” could be simplified to avoid repetition. Additionally, there are
minor grammatical errors (e.g., “ovarianmetastatic” should be “ovarian metastatic”), which need
correction for fluency.
Title: Krukenberg tumour in a 46-year-old black African woman with a background of ovarian
fibroma- A case report
Version: 1 Date: 15 Sep 2024
Reviewer's report:
1. While the introduction mentions that the presence of fibroma alongside Krukenberg tumors
can pose a diagnostic challenge, it could benefit from elaborating on why this is particularly
significant. A brief mention of the common diagnostic pitfalls or confusion with primary ovarian
tumors would enhance the reader’s understanding of the complexity.
2. The introduction does not clearly explain what makes this specific case particularly unique
compared to other reports of Krukenberg tumors. The authors should briefly state why this case
adds value to the existing body of knowledge—whether due to the rarity of the ovarian fibroma-
Krukenberg tumor combination or the specific patient demographics.
3. The introduction uses terms like "fibrothecoma" and "fibroma" without much explanation.
For clarity, the authors could provide a short explanation of these terms or why their presence
complicates diagnosis in the context of metastasis.
4. The paragraph structure could benefit from better transitions. For example, after describing
Krukenberg tumors, the text could smoothly transition to the diagnostic dilemma that the case
presents rather than abruptly stating that this report presents a unique case. A logical flow would
make the introduction more cohesive.
5. There is no information about the patient’s socioeconomic status, family history, or other
relevant personal factors that could add depth to the clinical presentation. The mention of
financial constraints later in the report suggests these factors play a role in treatment decisions,
and earlier mention of such factors would contextualize her treatment path better. Additionally,
including follow-up information, even briefly, would help readers understand the outcome after
discharge against medical advice.
6. Although the discussion references literature on similar cases, it could more clearly articulate
what makes this case distinct. The authors mention the rarity of ovarian fibroma coexisting
with metastatic tumors but do not explicitly compare this case to other reported cases. A clearer
statement about what new insights this case adds to the existing body of knowledge would
strengthen the conclusion.
7. Discuss the broader challenges of managing such cases in resource-poor settings, especially
when financial constraints impact care, and consider offering some practical management
recommendations.
8. The conclusion could also benefit from a brief summary that reinforces the key learning points
from this case, particularly emphasizing the diagnostic pitfalls and the importance of thorough
histological evaluation.
Title: Krukenberg tumour in a 46-year-old black African woman with a background of ovarian
fibroma- A case report
Version: 3 Date: 10 Oct 2024
Reviewer's report:
Thank you for giving me the opportunity to review this interesting case report "Krukenberg
tumour in a 46-year-old black African woman with a background of ovarian fibroma".
Almost all reviewer’s comments and recommendations were considered.
Recommendations: Accept
Title:  Assessing the factors associated with body image perception and quality of life of
Palestinian women undergoing breast cancer treatment: A cross-sectional study
Version: 2 Date: 09 Jun 2024
Reviewer's report:
This is a very good study but would be better as a qualitative study
there are too many statistics presented which could be replaced by better reporting of the main
findings. in clear English.  the excessive use of statistics detracts from the message
would revise the paper accordingly
Title:  Assessing the factors associated with body image perception and quality of life of
Palestinian women undergoing breast cancer treatment: A cross-sectional study
Version: 2 Date: 22 Jun 2024
Reviewer's report:
Generally, the topic of this paper is exciting. However, some problems remain unsolved. I hope
the following comments can help improve this paper further.
*In the background section, more information should be given about breast cancer, its causes,
and its prevalence (in Palestine and in the world). I see a very superficial background.
*A separate title should be opened in the study called "Theoretical and practical implications".
*A separate title should be opened and a deep literature review should be given.
*"Previous studies have reported that women who underwent radical surgeries, chemotherapy,
radiation therapy, and those who were in advanced stages of breast cancer reported higher
dissatisfaction with their body images compared to those who received less aggressive
treatments and those who were in early stages of breast cancer [6]."
More information (with references) regarding previous studies should be provided.
***Is it checked whether there is a multicollinearity between variables in the study? I would
hardly recommend giving vif values.
*I find the conclusion part very superficial. In addition to the statement "Health care providers
should address the psychosocial well-being of women with breast cancer receiving treatment
and care in the Palestinian health system", what suggestions and inferences can be made to health
care providers regarding the study.
*In addition, the contribution of the study to the literature and its original value should be
expressed more clearly.
Title: Correlation and predictive value of systemic immune-inflammation index for
dyslipidemia in patients with polycystic ovary syndrome
Version: 2 Date: 12 Mar 2024
Reviewer:  Ali Mansoor AlAmeri
Reviewer's report:
Dear respected Authors
Investigating the correlation amongst dyslipidemia, SII and PCOS represents a very fruitful area
of research. The article is well structured and written with excellent scientific language. It is
suggested to mention important things in the abstract including patients age range, selection
and exclusion criteria, consent and ethical approval. Some of these elements are needed to be
expressed even in the article full text. All the best for success.
Ali Mansoor.
Title: Correlation and predictive value of systemic immune-inflammation index for
dyslipidemia in patients with polycystic ovary syndrome
Version: 2 Date: 02 Apr 2024
Reviewer:  Nora Sabah Rasoul
Reviewer's report:
Dr. Nora Sabah Rasoul
Dear authors
The manuscript sheds light on an interesting subject. However, it also has several shortcomings.
I strongly encourage the authors to address the following points.
Abstract
AS we follow the journal guidelines the abstract should be structured so, please start it with the
background about the subject in the study.
The abstract should contain no abbreviations.
Add the study design in the abstract, please specify the case and the control groups.
Conclusion: did your result provides you with such conclusion, the odds is above one by 0.003,
do you think this result will be helpful for early diagnosis or to assess the association?
Materials and methods
Patient inclusion criteria
Line 58: It was noted that the sole measurement of total testosterone may not be a very
sensitive marker of androgen excess, we should measure total and free. Please read International
Evidence-based Guideline for the assessment and management of polycystic ovary syndrome
2023 how to assess biochemical hyperandrogenism.
Exclusion criteria
What about thyroid disorders?
Line 75 correct the word personnal.
Line 85 at which day of cycle the ultrasound was done?
Line 88 please add the references regarding the equations of calculating BMI & SII.
Statistical analysis
Line 94 rewrite the x bar symbol & I think you mean SD not just S.
Line 101please add the abbreviation (ROC).
Results
Please can you describe the four SII quartiles?
The title of Fig. one is not clear I suggest you to change it.
Discussion
Line 224 what do you mean by FSI? Not mentioned in the abbreviation list.
Line 225 (correlation analysis showed that SII was positively correlated with BMI, FSI, HOMA-
IR,) you didn’t mention in the methodology nor the results that you study the correlation with
HOMA-IR, if you did, please add it and the formula for calculating HOMA-IR with the reference
of the formula.
Please can you explain how are you confident that SII is an influencing factor of dyslipidemia
and the odds ratio is not so high just (1.003)?
List of abbreviations needs to be written again in alphabetical order and it does not contains all
the abbreviations.
Title: Correlation and predictive value of systemic immune-inflammation index for
dyslipidemia in patients with polycystic ovary syndrome
Version: 5 Date: 25 Apr 2024
Reviewer:  Hussein Wahhab Saleh Rabeea
Reviewer's report:
I hope this message finds you well. I have completed my review of your manuscript titled(The
predictive value of systemic immune-inflammation index for dyslipidemia in patients with
polycystic ovary syndrome) .
The material and methods was good #I think that the researcher adhered to the previous notes
and they were modified. Thank you