Reviewer’s report
Title: 
The effects of Saline Infusion Sonography on the histological quality of
endometrial sampling in women with postmenopausal bleeding
Version: 
1 
Date: 
09 Nov 2022
Reviewer's report:
1. General comment: the manuscript describes a secondary analysis of
endometrial samples obtained before and after sonohysterography (SCSH). The
data indicates that there are not differences in histological characteristics
between samples obtained before SCSH or after. The initial published trial
ESPRESSO) had similar findings. The data presented in this manuscript attempts
to dive deeper into the potential differences that could be caused by use of saline
before endometrial sampling as well as what factors might lead to insufficient
sampling.
2. Page 5, line 19: Specify that the national guidelines referenced are Dutch.
3. Overall, the results seem to be of little clinical significance. The discussion
does not seem to lead the reader to understand what these data could be used for,
or what next plausible steps are needed in future research.
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Is the study design appropriate to answer the research question (including the use
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presented?
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