Reviewer’ s report
Title: Effects of vaginal administration of conjugated estrogens tablet on sexual function in
postmenopausal women with sexual dysfunction: a double-blind, randomized, placebo-controlledtrial
Version: 0Date: 12 Apr 2020
Reviewer: Ibrahim A.
Reviewer's report:
Dear Respectable Editor
Thank you to give me the opportunity to review the manuscript entitled (Effects of vaginaladministration of conjugated estrogens tablet on sexual function in postmenopausal women withsexual dysfunction: a double-blind, randomized, placebo-controlled trial).The study was designed to evaluate the effects of vaginal administration of conjugated estrogenstablet on postmenopausal FSD using the Female Sexual Function Index (FSFI) as primary aim. Toevaluate vaginal pH, Vaginal Maturation Value (VMV), Normal Flora Index (NFI) and MostBothersome Symptoms (MBS) changes as secondary aim.Authors found no significant improvement of FSFI observed in estrogens arm compared toplacebo in each domain and overall index. The estrogens significantly improved vaginal pH andVMV , toward more acidity. In addition, they found no significant difference in NFI and MBSbetween arms.Authors concluded that there were no significant changes in FSFI, NFI, and MBS, but significantimprovement in vaginal pH and VMV in postmenopausal women with FSD treated with vaginallyadministered conjugated estrogens tablet.
Authors provide structured abstract.
In the introduction section, authors addressed the magnitude of the problem and they stated whytheir study was designed.In methods section, they provide the study design, approval and the trial registration number. Inaddition, they mentioned the patient recruitment, inclusion and exclusion criteria, randomizationand blinding, sample size justification, intervention and measured outcome (primary andsecondary).Results provided by the authors are clear with clear tables.In the discussion section, the authors compared their findings with others finding and theymentioned the strength, limitation faced during their study and the suggested future research.Finally, the study is well-designed study and of great importance to the readers and I accept it forpublication without any suggested changes from my side.Regards
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I recommend additional statistical reviewQuality of written English
Please indicate the quality of language in the manuscript:
AcceptableDeclaration of competing interests
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