Reviewer ’s report  
Title: Flow mediated vasodilation compared with caroti d inti ma media thickness in the 
evaluation of early cardiovascular damage in menopausal women. Influence of biological and 
psychosocial  factors  
 
Version: 1 Date:  20 Jul 2018  
 
Reviewer: JOHN STEVENSON  
 
Reviewer's report:  
Please include all comments for the authors in this box rather than uploading your report as an 
attachment. Please only upload as attachments annotated versions of manuscripts, graphs, 
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1. Precisions for glucose and lipid measurements should be given.  
2. Precisions for C -IMT and FMD measurements should be given.  
3. Full justification for omitting age from th e regression analyses must be made. The current 
explanation is not acceptable.  
4. Why not include menopausal age in the analyses for the postmenopausal groups.  
5. Discussion, 2nd page, lines 28 -32. Reference 43 is not appropriate for this sentence.  
6. The  figures need to show the R - or R2 - values. Some of the correlations may be 
mathematically significant but so weak that they are not biologically significant. The authors 
should comment on this.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
Yes 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
Unable to assess  
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
Yes 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an a dditional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
I recommend additional statistical review  
Quality of written English  
Please indicate the quality of language in the manuscript:  
Needs some language corrections before being published  
Declaration of competing interes ts 
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3. Do you hold or are you currently applying for any patents  relating to the content of the 
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4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
5. Do you have any other financial competing interests?  
6. Do you have any non -financial competing interests in relation to this paper?  
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below. If your reply is yes to any, please give details below.  
 
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