Reviewer’s report
Title: 
Malignant epithelioid neoplasm of the ileum with ACTB-GLI1 fusion
mimicking an adnexal mass: a case report.
Version: 
0 
Date: 
14 Jan 2022
Reviewer's report:
I read with great interest the manuscript, which falls within the aim of this
Journal. In my honest opinion, the topic is interesting enough to attract the
readers' attention. Nevertheless, authors should clarify some points and improve
the discussion, as suggested below.
Authors should consider the following recommendations:
- Manuscript should be further revised in order to correct some typos and
improve style.
- I recommend to add further detail to discuss, at least briefly, the role of
algorithms for differential diagnosis of pelvic/adnexal masses (authors may refer
to: PMID: 34321989; PMID: 31375049).
- Accumulating evidence suggests that the management of this type of cancer
should be personalized taking into account the performance status of the patient,
in particular in case of elderly women. It would be interesting to discuss this
point of paramount importance, referring to: PMID: 30542793.
- Several lines of evidence suggested that bowel malignant epitheliod
transformation may arise from endometriotic lesions, especially taking into
account the different types of the disease. It would appropriate to discuss this
topic, at least briefly, referring to: PMID: 31745637; PMID: 32751449.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
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