Reviewer’ s report
Title: Endometriosis of the vesico-vaginal septum: A rare and unusual localization
Version: 0Date: 30 May 2020
Reviewer's report:I read with great interest the Manuscript titled "Endometriosis of the vesico-vaginal septum: A rare
and unusual localization" (BMWH-D-20-00138).
The topic is interesting and the reported case novel enough to attract the readers' attention.Nevertheless, the authors should clarify some points and improve the discussion citing relevantand novel key articles about the topic.However, I have some recommendations for the Authors:-Manuscript should be further revised by a native English speaker.-Does this manuscript conform the The CARE Guidelines: Consensus-based Clinical CaseReporting (CARE), available through Enhancing the QUAlity and Transparency Of healthResearch (EQUATOR) network guidelines? It would be mandatory to declare about this element.-Accumulating evidence suggests that immune cells, adhesion molecules, extracellular matrixmetalloproteinase and pro-inflammatory cytokines activate/alter peritoneal microenvironment,creating the conditions for differentiation, adhesion, proliferation and survival of ectopicendometrial cells. I would discuss these points in the light of new theories about the pathogenesisof endometriosis, referring to: PMID: 28571791; PMID: 29743986; PMID: 32046116; PMID:31717614.-Although peritoneal superficial lesions and ovarian endometriomas represent the majority ofendometriotic implants within the pelvis, deep infiltrating endometriosis and extrapelvicendometriosis are the most challenging conditions to face off. Despite sometimes medical therapy
is enough to reduce symptoms and, in a large number of patients a complete eradication, with
nerve-sparing and vascular sparing approach is needed to restore the normal pelvic anatomy andits functions. I suggest further discussing this point mentioning these studies about the topic:PMID: 27579309; PMID: 30415128.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
YesDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
Not relevant to this manuscriptQuality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?
6. Do you have any non-financial competing interests in relation to this paper?
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If your reply is yes to any, please give details below.
I declare that I have no competing interestsReviewer Publication Consent. I agree for my report to be made available under an Open Access
Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manu-script is accepted for publication. Any comments that I do not wish to be included in the publishedreport have been included as confidential comments to the editor, which will not be published.Ifyou are not happy for us to publish this report, please contact the editorial office before completingthe review.If you wish, you can include your name in your published report. Please note you mustdecide whether to include your name at the start of the process and confirm this decision wheneverprompted. If you change your decision later, we will not be able to publish your name.
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