Reviewer’ s report
Title: Effects of vaginal administration of conjugated estrogens tablet on sexual function in
postmenopausal women with sexual dysfunction: a double-blind, randomized, placebo-controlledtrial
Version: 0Date: 15 Apr 2020
Reviewer: Hassan Salah Abduljabbar
Reviewer's report:
Please include all comments for the authors in this box rather than uploading your report as an
attachment. Please only upload as attachments annotated versions of manuscripts, graphs,supporting materials or other aspects of your report which cannot be included in a text format.
Please overwrite this text when adding your comments to the authors.ReportBMC Pregnancy and ChildbirthManuscript Number BMWH-D-20-00262Effects of vaginal administration of conjugated estrogens tablet on sexual function in
postmenopausal women with sexual dysfunction: a double-blind, randomized, placebo-controlledtrial
The title reflect the study accurately
Effects of vaginal administration of conjugated estrogens tablet on sexual function in
postmenopausal women with sexual dysfunction: a double-blind, randomized, placebo-controlledtrial
It involves, an important area of clinical gynecology
(Not Original)Michael J Gast Randomized Controlled Trial Menopause A Randomized Study of Low-DoseConjugated Estrogens on Sexual Function and Quality of Life in Postmenopausal Women Mar-Apr 2009;16(2):247-56. doi: 10.1097/gme.0b013e318184c440.There is an important massage might be important for clinician and researchesHas additional knowledge to the medical literature.
abstract is well written,and
the Objective This study was primarily aimed to evaluate the effects of vaginal administration ofconjugated estrogens tablet on postmenopausal FSD using the Female Sexual Function Index
(FSFI). Secondary aims were to evaluate vaginal pH, Vaginal Maturation Value (VMV), Normal
Flora Index (NFI) and Most Bothersome Symptoms (MBS) changes.Female sexual dysfunction (FSD) is prevalent in women with genitourinary syndrome ofmenopause (GSM). Vaginal estrogen is effective GSM treatment.
It is written in simple (English language with many spelling and grammar mistakes.)It is a good review
Material And Methods
A double-blind trial
was conducted in postmenopausal womenwith FSD (FSFI ≤26.55).
Sixty-seven participants were randomized into two arms;Vaginally administered conjugated estrogens tablet (0.625 mg, daily for 3 weeks then twiceweekly for 9 weeks, n=33),or placebo (n=34).Results :
ResultsThere was no significant improvement of FSFI observed in estrogens arm compared to placebo in
each domain and overall index (p=0.182).The estrogens significantly improved vaginal pH and VMV ,toward more acidity (p=Are the methods appropriate and well described?If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
AcceptableDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of this
manuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interests' below. I
I agree to the open peer review policy of the journal. I understand that my name will be included
on my report to the authors and, if the manuscript is accepted for publication, my named reportincluding any attachments I upload will be posted on the website along with the authors'responses. I agree for my report to be made available under an Open Access Creative CommonsCC-BY license (http://creativecommons.org/licenses/by/4.0/). I understand that any commentswhich I do not wish to be included in my named report can be included as confidential commentsto the editors, which will not be published.
I agree to the open peer review policy of the journal