Reviewer’s report
Title: 
Prevalence of Premature Ovarian Insufficiency and its determinants in
Iranian populations: Tehran Lipid and Glucose study
Version: 
0 
Date: 
04 Apr 2020
Reviewer: 
Mina Amiri
Reviewer's report:
During a cross-sectional analysis of a prospective data, the authors aimed to
estimate the prevalence of POI and assessing the influential factors. Although
the topic of the manuscript is very attractive and fills gaps of knowledge, it
needs minor revision before publication. I have provided comments below for
the authors to consider in revising the manuscript.
Abstract
- Study population is unclear; please specify age range of study participants. 
- Please change abbreviation of "OCP" to "OC" throughout the manuscript. OCP
is abbreviation of oral contraceptive pills. 
- Results section is unclear. Please rewrite this section for better understand. 
- Please add total number of participants. 
- Discussion section should remove from the abstract. 
- Please add one or two sentence about clinical implication of the findings. 
Introduction
- This section is appropriate. 
Materials and Methods
- 
Please rewrite materials and methods section to better understand. 
- Definition of POI needs to revise. 
- Inclusion and exclusion criteria are unclear. Please add more details about
study participants. 
- Please add study setting of the study. 
- What are influential determinants of POI? Please add more details. 
Results
- Sentence of "in addition, late menopause (>55) was …": please add 
unite
(years) to >55. 
- Table 1: You can merge widow and divorced participants. 
- Table 2 has not a footnote. Please define significance of bolded values in the
footnote. 
- Table 3: please transfer P-values to third column. Instead, regression
coefficient (95% CI) should transfer to second column. 
- Please add year as unite of age group to figure 1. 
Discussion
- Sentence of "applying the AFT model, we found that OCP consumption and
BMI were significant" should change to "applying the AFT model, we found that
OCP consumption and BMI were influential determinants of ANM."
- Sentence of "Contradictory results have been reported regarding the
relationship between contraceptive pills and age of menopause (41-44)": please
describe the results of these studies and mention the possible reasons of
contradictory results. 
- Please describe possible mechanisms for the associations between underweight
and declining ANM. 
Conclusion
- 
Please add more details of key findings. Clinical implications of the findings
should be added to conclusion. 
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the
authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you
recommend an additional statistical review?
If an additional statistical review is recommended, please specify what aspects
require further assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Acceptable
Declaration of competing interests
Please complete a declaration of competing interests, considering the following
questions:
1
. 
Have you in the past five years received reimbursements, fees, funding, or
salary from an organisation that may in any way gain or lose financially
from the publication of this manuscript, either now or in the future?
2
. 
Do you hold any stocks or shares in an organisation that may in any way
gain or lose financially from the publication of this manuscript, either now
or in the future?
3
. 
Do you hold or are you currently applying for any patents relating to the
content of the manuscript?
4
. 
Have you received reimbursements, fees, funding, or salary from an
organization that holds or has applied for patents relating to the content of
the manuscript?
5
. 
Do you have any other financial competing interests?
6
. 
Do you have any non-financial competing interests in relation to this
paper?
If you can answer no to all of the above, write 'I declare that I have no competing
interests' below. If your reply is yes to any, please give details below.
I declare that I have no competing interests.
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