Reviewer ’s report  
 
Title: The influence of the rs1137101 genotypes of leptin recep tor gene on the demographic and 
metabolic profile of normal Saudi females and those suffering from polycystic ovarian syndrome  
 
Version: 2 Date: 04 Jan 20 18 
 
Reviewer: Uma Addepally  
 
Reviewer's report:  
 
Comments  
 
1. In the anthropometric measurements and metabolic profile of POCS patients and 
controls(table 1) , the crucial factors like Leptin, Ghrelin and  HOMA -S the p values are  much 
higher than 0.05. Does it give any significance between PCO and controls?  
 
 
2. Does any allelic position specificity of Grouping of three genotypes -AA,AG and GG of 
rs1137101 exists.  
 
 
3. Although several variants are involved with rs1137101 any specific r eason to consider 
Gln233Arg.  
 
 
4. Some places  it is mentioned as Glu233 (Gln233)  
 
 
5. if there is no difference between PCO and control for rs1137101( non synonymous 
polymorphism),what is the role of  Gln 223  in leptin binding or in transmembrane signaling(li ne 
no 6 in results)  
 
 
These comments if relevant may be addressed in the Manuscript and may be accepted for 
publication as this is a first study on rs1137101in Saudi population.  
 
 
 
 
 
 
 
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the autho rs. 
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the edito rs. 
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
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