JerMa88/BMC_Womens_Health_Peer_Reviews huggingface dataset:
Title: Risk factors predicting residual lesion in subsequent hysterectomy following cold knife
conization(CKC) for high-grade squamous intraepithelial lesion(HSIL)
Version: 2 Date: 01 Jul 2022
Reviewer's report:
Thank you for your response to the review. I  am happy with your answers but do consider that
you need to add more detail on the microarray technology used. This is important as it influences
the readers understanding of the risk factors for residual disease post conisation.
Title: Risk factors predicting residual lesion in subsequent hysterectomy following cold knife
conization(CKC) for high-grade squamous intraepithelial lesion(HSIL)
Version: 2 Date: 07 Jul 2022
Reviewer:  Juan C. Felix
Reviewer's report:
The authors have adequately addressed my  comments and performed the additional suggested
analysis. I believe that this manuscript presents a significant addition to this field of study.
Title: Risk factors predicting residual lesion in subsequent hysterectomy following cold knife
conization(CKC) for high-grade squamous intraepithelial lesion(HSIL)
Version: 2 Date: 10 Jul 2022
Reviewer:  Diama Bhadra Vale
Reviewer's report:
Dear authors.
I read the paper reviewed, and it has improved significantly.
Some issues are pending.
1) Tables need legends.
2) You cited three micro-invasive cases. I would suggest giving more information on those cases,
as a table or in some sentences on the results.
3) For clinical management purposes, authors should state more clearly what is their opinion
on residual disease. Several studies show the low significance of residual disease in excision
follow-up. The residual disease does not translate into relapse; and when it does, it relapses as a
new precursor lesion and not as an invasive disease. In this way, recommending hysterectomy
would be excessive considering the harms and benefits. This opinion does not invalidate the
relevance of your data but needs to be discussed.
Best regards.
Title: Risk factors predicting residual lesion in subsequent hysterectomy following cold knife
conization(CKC) for high-grade squamous intraepithelial lesion(HSIL)
Version: 3 Date: 08 Aug 2022
Reviewer:  Diama Bhadra Vale
Reviewer's report:
Dear authors,
Please include in the tables the proper legends.
Table 1: TCT, HR-HPV
Table 2: OR, 95%CI, P
Table 3: B, SE, OR, 95%CI
Figure 1: CKC, ROC
Table 4: CKC. OR, 95%CI, P
Table 5: HR-HPV
Best regards.
Title: Estradiol and Intrauterine Device Treatment for Moderate and Severe Intrauterine
Adhesions after Transcervical Resection
Version: 2 Date: 05 Jun 2022
Reviewer:  Cihan Kaya
Reviewer's report:
The paper needs a typo and grammar revision for better understanding
The limitations should be detailed (small number in total, and discordance between study groups)
Title: Estradiol and Intrauterine Device Treatment for Moderate and Severe Intrauterine
Adhesions after Transcervical Resection
Version: 2 Date: 01 Jul 2022
Reviewer's report:
1. Abstract
Line 21: Objective: Information on dosages of estradiol shall be included in the “Methods”.
Lines 24-27: The Methods should include detailed information about the selection of subjects,
interventions and evaluation criteria.
2. Main text
Lines 80-81: “Exclusion criteria were the following: (1) minimal adhesion (AFS score < 5); (2)
previous hysteroscopic adhesiolysis;” these two criteria were automatically evident and should
not be mentioned, when considering and applying the selection criteria.
The Methods should include detailed information about the selection of subjects, interventions
and evaluation criteria. Lines 112-117 of the Results section should be moved to the Method.
The timepoints of follow-up visits were not consistent with those stated in the Abstract, and
not clear.
There is an important drawback of the study, the number of cases included in the groups A and C
were small, limiting the validity of conclusions, and should be mentioned within the Limitations.
3. English syntax and grammar should be thoroughly improved before re-submission for
consideration.
Title: Factors Affecting Timely Breast Cancer Treatment among Black Women in a High-risk
Urban Community: a Qualitative Study
Version: 2 Date: 24 May 2022
Reviewer's report:
Comments:
I am so glad to review this interesting research paper. It is important to understand the factors
affecting breast cancer treatment delay for black women which is a meaningful topic. Here are
my suggestions for the study:
Introduction
1. Why was the study only conducted in the communities with the highest degree of breast cancer
treatment delay? The reason should be given.
2. The factors of treatment delay in previous studies should be reviewed, especially in some
studies on nHB.
Methods
1. In the abstract I can see the researchers chose the community with the highest degree of breast
cancer treatment delay, and how to identify the “highest degree”. Because the methods part,
only defined the “hotspot communities”. Are these two consistent?
2. How to formulate the interview guidelines, and how to keep the consistency of the interviews
between the two researchers that should be introduced.
3. How to ensure that the number of participants is sufficient and representative? How to ensure
information saturation? only eight were breast cancer survivors, two caretakers of breast cancer
survivors, and seven professionals were recruited. Is that enough?
4. The purpose of this study is to understand the factors affecting timely breast cancer treatment
delay. Then, what is the necessity of interviewing professionals?
Results & Discussion
There are not too many innovative findings in the study, and most of the results can be known
from previous studies, which do not reflect the characteristics of black women in communities
with the highest degree of breast cancer treatment delay.
Title: Factors Affecting Timely Breast Cancer Treatment among Black Women in a High-risk
Urban Community: a Qualitative Study
Version: 2 Date: 15 Jun 2022
Reviewer:  John Benedict B. Lagarde
Reviewer's report:
This is an interesting article about the perceived factors or variables that affect the uptake of
breast cancer treatment among Black women in a high risk community in the US. To further
improve the paper, I kindly ask the authors to address the following questions/concerns:
1. Considering the fact that the participants are dealing with a terminal illness like breast cancer,
the authors should include an ethical section to explain how they dealt with distress that the
study may have caused to participants.
2. Who did the interviews? It is conventional in qualitative research to provide information
about the background of the interviewers e.g., gender, age, educational background, professional
training, etc.
3. Relatedly, what was the relationship of the researchers to the participants? What did the
participants know about the researchers?
4. Although some parts of the methodology section are fairly written, the authors failed to state
the methodological orientation/qualitative research design utilized by the researchers to underpin
the study.
5. How did the researchers ensure the credibility, dependability, and transferability of the
emergent themes and subthemes from the study?
6. In the results, it would be interesting to know about the educational background of the
participants because this particular variable may have an influence on their explanatory models
to certain aspects of the illness i.e., breast cancer treatment. It will also address questions such
as: “Were there any biases among those who graduated from college vs those who are not?”
7. Also, it would be clearer to the readers if the authors included a detailed table about the
socio-demographic and clinical characteristics of the participants e.g, educational background,
monthly or annual income, time interval from cancer diagnosis to treatment, presence of
Medicaid or other health insurances, etc.
Title: Awareness of Human Papillomavirus and Acceptability of the Vaccine among Women
in Palestine: Is It Time for Policy Adjustment?
Version: 1 Date: 07 Mar 2022
Reviewer:  Monjur Rahman
Reviewer's report:
In this paper,  authors assess the awareness, knowledge and acceptability of Palestinian women
on human papillomavirus (HPV). Based on questionnaires consisted of three sections) on 7223
women analyzing data using SPSS, authors find that, women of West Bank and Jerusalem (WBJ)
had better awareness, knowledge and acceptability than that of Gaza Strip.
The paper is well written. The sample size is large and the response rate is high.
It is not  understood  why  did they chose Monthly income # 1450 ?
Rather than collecting major data (61.8%) from hospitals (26.7%) and primary healthcare centers
(35.1%) it might be more appreciating to collect more data from Public spaces (38.2%).
There are few typos in the manuscript.
Title: Awareness of Human Papillomavirus and Acceptability of the Vaccine among Women
in Palestine: Is It Time for Policy Adjustment?
Version: 1 Date: 22 Jul 2022
Reviewer:  Mario Palumbo
Reviewer's report:
I was pleased to review this paper
The methodology used by the Authors is appropriate for the purpose of the article description.
The English language is fluid and well understood. Nevertheless, minor revision is needed.
The abstract is well defined.
Regarding the introduction, I find this article very interesting, you can add this paper to deepen
the topic.
DOI: I recommend integration with this job 10.1111/jog.14276
As regards the paper’s structuring (methods/discussion): There is a good structure of the project.
I think you need to articulate the choice of the questionnaires in more detail.
What precautions did you have in the selection of the samples, in particular on the role of
personal external factors that could in any case alter the study?
Considering that in your opinion the level of education and the social status can influence the
level of knowledge of certain concepts, how can we reach populations with a lower cultural
level?
Are there differences of view between people of the same family or people who have attended
the same school?
Results
- Cite and analyze the limits of the study in a more schematic way;
- The statistical structure seems to me well done.
Conclusion
For you, most women showed good acceptance of the HPV vaccine: in literature have you found
similar projects?
Increase the number of references
Title: Reassessment of intensive surveillance practices adopted for endometrial cancer survivors
Version: 3 Date: 02 Feb 2022
Reviewer's report:
Thank you to giving me the chance to review this study.
The argument is very important and matter of discussion and the study adds interesting findings
to medical literature.
I suggest to include molecular classification of EC in the introduction section ( doi: 10.1016/
j.ygyno.2021.02.030; doi: 10.1016/j.ygyno.2021.05.029. Epub 2021 Jun 1.
PMID: 34088515) and discuss it in the discussion section.
Please provide a strenghts and limitations paragraph at the end of the discussion (i.e. lack of
power analysis, lack of stratification for prognostic groups according to ESGO guidelines).
It is a common belief that not all patients with EC require the same surveillance.
Title: Reassessment of intensive surveillance practices adopted for endometrial cancer survivors
Version: 3 Date: 28 Feb 2022
Reviewer's report:
This article includes some interesting data.
I have the following comments to the Authors:
• Authors should check for some mistakes in the text:
- Line 59: “systematic” should replace “systemic”;
- Line 154: check if you are sticking to singular of plural: “The overall risk were 5.2%, 8.2%,
24.2%, and 27.1% in stages I, II, III, and IV, respectively”);
- Line 169: “FIGO” instead of “FIFO”
• Authors mentioned 2011 Society of Gynecologic Oncologists recommendations for post-
treatment surveillance of endometrial carcinoma. However, an update of these recommendations
was released in 2017 and should be included in the article: https://doi.org/10.1016/
j.ygyno.2017.03.022
• References: citation [9] and citation [19] refer to the same article
• Introduction, line 56: a reference is needed (“Approximately 15,000 cases were newly
diagnosed in 2015, and 80% of the patients were categorized as Stage I and II”);
• Introduction, line 82: a reference is needed: “There is an increasing number of endometrial
cancer patients in Japan, with an incidence of 25.7/100,000 women newly diagnosed in 2017,
which was more than double that in 2000”.
• Discussion, lines 232-236: a reference is needed
• Results: Authors mentioned they performed an analysis to detail the association between the
recurrence site and diagnostic modality for detecting recurrence. However it would be interesting
to have information about the detection rate of these diagnostic items related to the recurrence
site (e.g. in how many cases a positive pelvic examination was associated to the presence of
local recurrence?)
• Discussion: Authors complete discussion mentioning molecular prognostic factors as an item to
predict the risk of recurrence in endometrial cancer and tailor post-treatment follow-up based on
molecular characteristics. They also mentioned that tumor grade and deep myometrial invasion
could be independent risk factors for recurrence. The association between classic, well-known,
clinicopathologic factors in EC, such as myometrial invasion, tumor grade and lymphovascular
space invasion and novel molecular ones is a very hot topic in literature to date. Authors may
expand the discussion about this including latest evidence in literature describing the prognostic
value of TCGA molecular groups and classic histologic factors in EC.
Title: Knowledge, attitude, and factors associated with induced abortion among female students
‘of Private Colleges in Ambo town, Oromia regional state, Ethiopia: -A cross-sectional study.
Version: 3 Date: 25 Jul 2022
Reviewer:  Digafe Tsegaye Nigatu
Reviewer's report:
Title: Knowledge, perception and factors associated towards induced abortion among female
students ‘of Private Colleges in Ambo town, Oromia regional state, Ethiopia: -A cross-sectional
study.
1. The question posed by the authors (i.e. factors associated with induced abortion) is not
indubitably new. There are similar studies have been conducted in other parts of Ethiopia.
However, this research question is very important and the authors have carried out the study
among female students in private college, which is important.
2. The methodology used by the authors is suitable for a cross sectional study. However, the
description is insufficient and there were inadequate details for others to replicate the effort.
For example, the variables particularly the outcome variable and tools used were not obviously
defined.
3. With respects to sample size estimation, the authors used an expected proportion of 50%.
However, there are lot of related studies carried out in Ethiopia. Again the description for
sampling procedure is inadequate.
4. The analysed figures appear to be genuine. However, authors should point out the missing
data in the tables. For instance in the “Table 1”; variable “Age” has a missing value.
Title: High burden of invasive and non-invasive cancer among women aged 20- 49 years. The
situation in Geneva, Switzerland
Version: 1 Date: 03 Jun 2022
Reviewer:  Anthony B. Miller
Reviewer's report:
The authors have made excellent use of the data on invasive and non-invasive cancers in the
Geneva Cancer Registry.  It is almost unique in my experience for a cancer register to include
data on non-invasive cancers.  What I missed, however, was a recommendation on care of
these cancers directed to gynecologists.  Would it be possible for such a recommendation to
be provided?
Title: High burden of invasive and non-invasive cancer among women aged 20- 49 years. The
situation in Geneva, Switzerland
Version: 1 Date: 23 Jun 2022
Reviewer's report:
Dear Editor,
I read with interest the manuscript by Rapiti et al titled “High burden of invasive and non-
invasive cancer among women aged 20-49 years. The situation in Geneva, Switzerland.” The
manuscript aims to describe cancer incidence at ages 20-49 in women (including non-invasive
tumours) and compare it to men.
My detailed comments below
I would try to be more specific in the discussion as many readers will not have time to cross
check with the table in the results. For example
‘only one type of cancer is responsible of 72% of all non-invasive tumours.’ Could be reworded
to ‘in-situ cervical cancer was responsible for 72% of all non-invasive tumours’. I note that the
text is explicit in the highlight bullet points.
It would be of interest to quote some of the literature around evidence (or lack thereof) for
lowering the age breast screening to 40 but not recommended at younger ages. This includes
the UK Age trial https://doi.org/10.1016/S1470-2045(20)30528-3, also see ACS Breast Cancer
Screening Guidelines
I think it important to have a discussion around the fact non-invasive cancers are mostly
diagnosed through screening. Particularly important for CIN3. This is an asymptomatic
condition that would not be identified if no screening existed.  So although the rates are very
high in young women this is preventing cervical cancer rates being high and probably lowering
the age at which the disease is diagnosed in the process. Agree that it is also important to say
that HPV vaccination will (if coverage is high) probably almost eliminate CIN3 from this age
group, but it will take another 15years or so to materialise.
I also think acknowledgement that non-invasive disease comparisons between females and males
are challenging because screening for breast and cervix is not relevant to males and the difference
in rates of non-invasive melanoma between sexes is much smaller and the Cis suggest non
significantly different.
The text in the conclusion of the abstract seems to be pertinent however it wasn’t fleshed
out in detail in the discussion, specifically these points: ‘better primary prevention strategies,
personalized risk assessment and tailored screening, as well as increased awareness of women
and health professionals about health risks in young adults.’
Minor comments
Figure 1. would suggest adding ‘European age-adjusted rates’ in the figure legend.
Table 1. Would also suggest clarifying that rates are European age-adjusted
Title: Factors associated with an unfavorable clinical course in hospitalized patients with pelvic
inflammatory disease: A retrospective cohort study of 117 patients from a Japanese academic
institution
Version: 1 Date: 20 Dec 2021
Reviewer's report:
Dear authors,
I think, that the article is well written and is considerable thanks to its originality. On the other
hand, I have some recommendations in order to improve the quality of the report.
1. If possible please indicate the period between onset of the symptomps and the onset of the
antibiotics. If these data is available, is there a relationship between this duration and need for
surgical intervention?
2. If possible please specify the imaging results of the patients (bilaterality of abscess, size of
abscess, any finding of rupture) that could be a risk factor for the surgical intervention.
3. If possible please indicate microbial characteristics (cervicovaginal, abscess or bloood cultur).
4. If possible please specify the type of surgival interventions.
5. Please explain the reason of high endometriosis and endometrioma rate in patients with PID
(in discussion).
6. Please compare the high TOA rate in PID patients with the literature and explain the reasons.
I hope that these additional data may improve your article and take more attention to the journal.
Sincerely.
Title: Factors associated with an unfavorable clinical course in hospitalized patients with pelvic
inflammatory disease: A retrospective cohort study of 117 patients from a Japanese academic
institution
Version: 1 Date: 26 Feb 2022
Reviewer's report:
Thank you for the opportunity to evaluate this report. The paper is about the determining
factors associated with emergency surgery and prolonged hospitalization in patients with pelvic
inflammatory disease. I think the paper could publish in this journal with minor revision. I have
the following comments:
1. Please give more information about the 3 cases without TOA and underwent emergency
surgery. For what indication was surgery performed? What were the surgical procedures applied
in these patients?
2. Please correct the typos in Table 1 (Chramidia trachomatis).
Title: Factors associated with an unfavorable clinical course in hospitalized patients with pelvic
inflammatory disease: A retrospective cohort study of 117 patients from a Japanese academic
institution
Version: 4 Date: 24 Apr 2022
Reviewer's report:
Thank you for opportunity to reevaluate the manuscript. The authors made most of the revisions I
requested. The article can be published in the journal after "Chramidia trachomatis"  is corrected
as "Chlamydia trachomatis" in table 1 row 23.
Title: Factors associated with an unfavorable clinical course in hospitalized patients with pelvic
inflammatory disease: A retrospective cohort study of 117 patients from a Japanese academic
institution
Version: 4 Date: 16 May 2022
Reviewer's report:
Dear authors,
I think that this study, which is related to poor clinical outcomes in PID patients, is original
and of high quality. However, I would like to make a few suggestions that will take attention
to the study:
1. The conclusion part of the abstract does not fully answer the aim of the study. The first
sentence is unrelated to the purpose. For example, TOA is a factor that is associated with both
emergency surgery and prolonged hospitalization, but not specified.
2. One of the keywords "intrauterine manipulation" is irrelevant to the content and main results
of the study. Kindly write "tubo-ovarian abscess" instead.
3. If there is data on the duration of IUD use, please add it to the analysis. If not, please add it
to the limitation of the study.
4. Kindly do not repeat the data in Table 1 as text.
5. I think that the section about the details of the surgeries is unnecessary because it disrupts the
focus on the subject of the study. Please remove that part from the text (Lines from 106 to 117).
6. In the first paragraph of the discussion, please shortly state the purpose and main results of
the study. And then you can proceed to the discussion in other paragraphs.
7. Kindly correct the word "gynecological" as "gynaecological" (British English) or
"gynecologic" (American English) throughout the article.
8. Kindly correct the word "Chramidia" as "Chlamydia" in Table 1.
9. You may also add a subgroup analysis, which includes an analysis of parameters associated
with emergency surgery in the TOA group.
Best regards.
Title: Factors associated with an unfavorable clinical course in hospitalized patients with pelvic
inflammatory disease: A retrospective cohort study of 117 patients from a Japanese academic
institution
Version: 5 Date: 18 Jul 2022
Reviewer's report:
Dear authors,
Thank you for the revisions that you made under the recommendations. I think that the study is
suitable for publication and strongly recommend accepting this high-quality article.
Best regards
Title: Conservative interventions and clinical outcome measures used in the perioperative
rehabilitation of breast cancer patients undergoing mastectomy: a scoping review.
Version: 1 Date: 29 Jun 2022
Reviewer's report:
The manuscript is well-organized and addresses an important issue in perioperative physical
rehabilitation for women with breast cancer.
The most recent version of the AMSTAR assessment tool evaluates reviews based
on whether there justifications are provided for language restrictions (https://amstar.ca/
Amstar_Checklist.php). As such, I would recommend that explanations are provided in the
Methods or Discussion as to why the language was restricted to English (and specifically
French).
The manuscript indicates that the literature search was performed up to Jan 2021. As it has now
been over 1.5 years since the search was done, I would advise that an updated literature search
be performed to ensure that all recent relevant studies are included.
Some grammatical errors are evident in the manuscript. I would suggest that the manuscript be
edited for language.