JerMa88/BMC_Womens_Health_Peer_Reviews huggingface dataset:
Title: Prenatal opioid use as a predictor of postpartum suicide attempts among reproductive-age
women enrolled in Oregon Medicaid
Version: 2 Date: 13 Dec 2023
Reviewer's report:
Thank you for the opportunity to review this manuscript. This is an important topic.
Methods:
-Why are only patients that had “live births included in the data”?
- Are SDOH available in Medicaid data?
- please clarify the difference in categories w OUD and SUD. It would make sense that any
patient dx with an OUD would be included in the SUD category.
- DCFY involvement and family unit connection are not mentioned. This should be included  at
minimum in the limitations because could have significant confounding on study outcome.
- Inclusion of psychiatric comorbidities and suicide attempts prior to pregnancy would
strengthen the data analysis plan
Results:
It is confusing that the results report that majority of suicide attempts occurred in individuals
w OUD, but they did not find statistically significant differences in total (all means) suicide
attempts in those w prenatal and postnatal OUD. Please explain.
Conclusion: recommend revising. Statement that “reproductive-aged women enrolled in Oregon
Medicaid are at an increased risk of OUD and suicide attempts during pregnancy and
postpartum” is confusing. The data analysis here was of Oregon Medicaid reproductive age
women. I am not sure what the comparator is the authors are referring to when stating this
population is at increased risk- is it national rates?  Please revise to align the conclusion with
the study results.
Title: Prenatal opioid use as a predictor of postpartum suicide attempts among reproductive-age
women enrolled in Oregon Medicaid
Version: 3 Date: 03 Mar 2024
Reviewer's report:
I thank the authors for addressing my prior comments; I agree with the authors that the
manuscript is much improved.
Two additional comments:
First, I would recommend changing the wording about the OUD diagnosis to not say individuals
"received an OUD diagnosis" but rather that they rendered a claim with an OUD diagnosis (either
prenatally or postpartum)
Second, if the authors desire to keep the part of the line in the discussion that says "congenital
heart disease", I do request that they provide justification as, to my knowledge, the association
between maternal OUD and that outcome is not scientifically justified.
Title: The Association Between Diet Quality Index-International and Dietary Diversity Score
with Preeclampsia: A Case–Control Study
Version: 1 Date: 14 Dec 2023
Reviewer's report:
Dear Editor, the main study's objective is interesting, however are some parts that need to be
considered as follows;
Abstract
Line 34: Please provide the full name for "PE" immediately, followed by its short name.
Method
-please add the information in general characteristics regarding whether the pregnancy was
planned or/ unplanned
-the participants were primiparous or multiparous?
-age differences are not too varied among participants, so how do the authors consider this
variable for matching, and why did not consider the pre-gestational BMI  as reported as an
average of 26.09 kg/m2
- Why didn't the authors include the gestational weight gain of the first and second trimesters
in their study? The importance of GWG and pre-pregnancy BMI is evident, so it should be
incorporated into the statistical analysis to improve the results and discussion afterward.
( Risk of preeclampsia by gestational weight gain in women with varied pre-pregnancy BMI: A
retrospective cohort study Front. Endocrinol., 14 October 2022.Sec. Obesity. Volume 13 - 2022
| https://doi.org/10.3389/fendo.2022.9671020).
- please add data on antenatal dietary supplements regularly / irregularly (eg; folic acid)
Result
-please replace pre-pregnancy BMI with BMI in the text, table, and footnote of tables as well.
Discussion
-line235-238: please rewrite
-Line 244-change the "on the flip side"
-please modify the discussion by the inclusion of GWG and pre-BMI
Title: The Association Between Diet Quality Index-International and Dietary Diversity Score
with Preeclampsia: A Case–Control Study
Version: 1 Date: 14 Jan 2024
Reviewer's report:
It was a case-control study aimed to determine the association between DQI-I, DDS, and
preeclampsia. Overall, it was a well-written manuscript and worth publishing. However, there
were some points in the article that if considered, the quality of the article will be improved.
Abstract
First, the aim of the study should be inserted in the last sentence of the background.  Please
move it from methods to background.
Second, please define in the methods that it was a case-control study.
Discussion
You have mentioned the use of a valid and reliable FFQ  and careful selection of a control group
as strengths, while the ethical and professional obligation of every researcher is to ensure the
quality of her or his study tools and methods, and if she or he does this, it is not considered a
strength.
Title: The Association Between Diet Quality Index-International and Dietary Diversity Score
with Preeclampsia: A Case–Control Study
Version: 3 Date: 21 Feb 2024
Reviewer's report:
Dear Editor, thanks for this opportunity.
The authors almost performed the revision, but still, there are some parts.
-line 154: please specify the version of SPSS you have used.
- line 167-169: The use of pregnancy BMI by the author is unclear, as gestational weight gain
(GWG) would be more relevant to the study's main objective.
line 109-110:    Please clarify whether the BMI referred to is pre-pregnancy or during pregnancy.
"The pregnancy and pre-pregnancy weight and height were obtained to calculate the body mass
index (BMI)."
lines 167-169: There is no significant association between the groups, however, the following
sentences contradict this statement and report the existence of the same association.
line 278-286: The references regarding pre-pregnancy BMI and GWG (reference 43-44) should
be included to build similarities/differences. The authors used the term "pregnancy BMI",  it's
not clear what they meant by it.
Title: The Association Between Diet Quality Index-International and Dietary Diversity Score
with Preeclampsia: A Case–Control Study
Version: 4 Date: 13 Mar 2024
Reviewer's report:
Dear Editor,
The authors have completed the revision. To improve clarity, line 171 should be corrected.
line 171: please replace "Preeclampsia subjects had a higher during pregnancy BMI than
healthy.." with  "Preeclampsia subjects had a higher BMI during pregnancy  than healthy.."
Title: Has Zika been forgotten? A qualitative exploration of knowledge gaps, perceived risk and
preventive practices in pregnant women in Malaysia
Version: 1 Date: 11 Jan 2024
Reviewer's report:
Introduction: Need to include the implementation and strategy that Malaysia is currently doing
to prevent the zika transmission.
106: When was the study was done, how long the duration, how many participants were involved
in this study and how did you determine the sample size. Please explain more in your method.
109 – 111: The study was a collaborate with community organization and women’s health clinic.
Where was the study done (any part of Malaysia?) and why was it chosen for this study? Is there
a reason? Like maybe places where dengue or zika transmission is known.
111-112: “use online platforms and social media to advertise”. How the recruitment was done
using this platform. Where you advertise your study, either on an open website or targeted
specific community website. I just thought if it was an open website, you would probably reach
an audience from all over the country. If someone sees your advertisement and is interested,
what should they do (register online, call in charge person etc.) and how you make the selection.
122-123: In your manuscript, the data collection was conducted by virtual interviews through
video chat. How participants involved in one session and how long the session? How do you the
arrangement for the data collection? By appointment or the interviewer will calls the participant
during office hour etc.
113-134: Please describe specifically how the process of data collection was done from start to
the end to make the reader clearer about the data collection process.
143-145: Data confidentiality. Your data collection was video/audio-recorded interview. How
do you ensure your recorded data was kept safe? For example, store the data in password-
protected database or discard all the recorded video/audio after the study is complete.
152: How do you obtain the written informed consent from the participants as you use a virtual
platform as a data collection medium.
160-162: What is the definition of many in your study? More than one or more than half of the
participants? Suggestion to describe in percentage.
236-237: Repeated statement as in introduction (objective). Suggestion to discard this sentence
or rephrase.
It would be more comprehensive if the authors could make some comparison between their
finding with the previous studies in Malaysia or from neighbouring countries in your discussion.
Please provide a copy of the questionnaire in the appendix.
Title: Has Zika been forgotten? A qualitative exploration of knowledge gaps, perceived risk and
preventive practices in pregnant women in Malaysia
Version: 1 Date: 27 Jan 2024
Reviewer's report:
Good day, author and teams,
Abstract:
1. Structured and well-explained reflect the needs of the paper as a whole.
Background:
Good background study and suitable for technical paper with laymen's terms.
Method:
The author used a qualitative study and explained the methodology thoroughly to minimise bias.
Result:
This study's respondents were among seven pregnant women with tertiary education.
The input gained from this study was not reflected well as the backgrounds of all interviewees
were the same. The variety of backgrounds among respondents needed to study different
knowledge gaps as the level of education commonly showed the various inputs to collect.
However, this study had well-extracted from the interview session with respondents. The
author mentioned exploring the knowledge gap, perceived risk and preventive practices among
pregnant women.  This study was good to begin with as an initial study for this issue.
Through a qualitative study, the author was able to learn the knowledge gap but was unable to
measure the actual gap in the population.
The perceived risk input was identified well in this study through this qualitative method.
Preventive practices among pregnant women were explored in this study however the actual
numbers were unable to be defined in the population.
Discussion:
The author explained well in the discussion related to results. The author did mention health
education from healthcare providers is needed.
The author also highlights the importance of social media to convey the message towards
pregnant women as a good method.
The author did mention the limitations of the study well and highlighted the potential bias in
the study.
Conclusion:
The author stated the result aligned with the problem statement of the study.  The author also
gives suggestions related to information gained throughout the study.
Additional suggestion:
The author has the potential to further this exploration of qualitative study to quantitative study
in future to gain more input. Hence, the health promotion and education related to ZIKV among
pregnant women in Malaysia will be able to address from the ground. The good impact on study
and numbers may show the importance and value of the information related to ZIKV in the eyes
of policymakers in health.
Title: Has Zika been forgotten? A qualitative exploration of knowledge gaps, perceived risk and
preventive practices in pregnant women in Malaysia
Version: 3 Date: 23 Feb 2024
Reviewer's report:
Dear authors,
Thank you for the revised.
I've gone thru the details and the authors managed to explain well all the suggestions that I have
requested.
The authors expressed the study methods thoroughly and may help other scholar to use as
revision in future.
Well done and Thank you.
Title: Clinical Outcomes of Screening and Diagnostic Mammography in a Limited Resource
Healthcare System
Version: 2 Date: 24 Dec 2023
Reviewer's report:
1. Results:
Results written in vague way (too many numbers, %, etc..), please rephrase and make them more
clearly.
2. Discussion:
The discussion part is too short and concise, please expand the discussion section.
3. References:
The age of refences in the article are more than 5-year-old, please use recent sources and update
information.
4. Spelling mistakes
Title: Clinical Outcomes of Screening and Diagnostic Mammography in a Limited Resource
Healthcare System
Version: 3 Date: 06 Feb 2024
Reviewer:  Khawlah Ammar
Reviewer's report:
thank you for the authors the manuscript dramatically improved, some points to be highlighted:
in the methods: would you please change the design to retrospective cross sectional study
would you please add "significantly" in the last line in the first paragraph in results section.
Table 1: double check the numbers of diagnostic group in the following domains:
Previous MM
Personal history of BC
Hormonal therapy
Family History of BC, as you added missing I think you can check all the numbers in the table.
Table 2: Add N to each domain you added it only for "core breast biopsy result"
regarding BIRAD 0: you just mentioned them, did they were called? or they just do not want
to complete the follow up procedures?
I was aiming to find out the associations between detection rate in the diagnostic group and the
screening group, in the diagnostic 9/349 = 2.6% while in the screening 2/606= 0.3%
Title: The Mediating and Moderating E#ects of Resilience on the Relationship between Sleep
Quality and Psychological Distress in Chinese Women with Infertility
Version: 1 Date: 03 Oct 2023
Reviewer's report:
This paper is an interesting topic in the infertility area. However, some issues should be revised.
- The assumptions are not clear.
-The definition of psychological distress is not clear.
- Table 1 shows that women with children adopted had lower psychological distress than those
without children. Why did you include 164 women with  Children adopted? How did you control
the effect of this confounder?
The implication of the finding is not presented well.
- There is no conclusion section/paragraph in the discussion.
Title: The Mediating and Moderating E#ects of Resilience on the Relationship between Sleep
Quality and Psychological Distress in Chinese Women with Infertility
Version: 3 Date: 10 Feb 2024
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
No - there are minor issues
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The authors have made significant revisions to the manuscript, now
clearly have a set of aims that align with the methods, revising the discussion to expand on the
implications of the findings and the quality of the English has greatly improved. There are some
minor issues that remain
REQUESTED REVISIONS:
While they authors have made significant improvements in many areas of the manuscript that
are some issues that still need clarification. 1. a prior reviewer suggested the term "women
with infertility" rather than infertile women and this change was made in a few areas but not
all, including the title. 2. Pg 2 - the authors refer to "pressure" and "negative pressure" this
seems an imprecise term - do they mean anxiety or worry? 3. The authors purport to using the
Chinese version of the measures, yet cite the English version of them; the correct citations of the
properties of these measures in Chinese should be cite. Further, the authors say the measures have
"good reliability and validity" without specifically stating what that is - also Cronbach's alpha
is a measure of internal consistency, it does not provide data that show reliability and validity.
4. Finally, while the majority of English syntax and grammar issues have been corrected, some
remain as do numerous typos.
ADDITIONAL REQUESTS/SUGGESTIONS:
Change pressure to something more specific to psychology
Title: Association of tet methylcytosine dioxygenase 2 and 5-hydroxymethylcytosine in
endometrioid adenocarcinoma and its clinical significance
Version: 1 Date: 07 Aug 2023
Reviewer:  Mohammad Hasan Sheikhha
Reviewer's report:
This is a good manuscript that needs some grammar corrections plus some points as below:
Abstract.: Results TET2+5hmC+  "You have to explain what + means here"
Results TET2+5hmC+  coexpression was more common in pericarcinomatous tissues  "THERE
IS NO MENTION OF EXAMINING THIS TISSUE IN THE METHOD"
Introduction: The prevalence of EC increases year by year, and the age of onset inclines to the
young [2] "This sentence is not clear"
Although most EC patients receive early diagnosis and have a good overall prognosis, there are
still 15%-20% of EC patients with postoperative recurrence and tumor metastasis[3]. Due to
insensitivity to traditional radiotherapy and chemotherapy, patients in advanced stage or with
recurrent EC always have poor prognosis, with the 5-year survival rate being approximately
17%-30% [4, 5]. "These sentences are against each other"
Discussion: Some parts are basic explanations about the genes that seems to belong to the
introduction part such as:
TET2 gene is found in chromosome 4q24 and has 11 exons with a total length of 150 kb,
encoding TET2 protein and IDAX protein. TET2 protein can mediate DNA demethylation
through binding to specific functional regions of the genome.
or
5mC can be hydroxylated to 5hmC under the catalysis of TET protein. 5hmC plays a key role in
neural development, and abnormal 5hmC expression was found in some neurological diseases
such as Alzheimer's disease[28].
Title: Association of tet methylcytosine dioxygenase 2 and 5-hydroxymethylcytosine in
endometrioid adenocarcinoma and its clinical significance
Version: 1 Date: 13 Aug 2023
Reviewer's report:
Thank you to have an opportunity to review the article, titled of “Coexpression of tet
methylcytosine dioxygenase 2 and 5-hydroxymethylcytosine in endometrial cancer and its
clinical significance" The current article is interesting but has some problem.
1.  What is the definition of positive or negative IHC?  Is staining determined by the glandular
epithelial cells or stromal cells?
2. The information of histological subtypes (endometrioid carcinoma, serous carcinoma, clear
cell carcinoma, ###) is important for survival analysis. Please add the information of histological
subtypes.
3. The information of histological subtype or histological differentiation should be included in
multivariate analysis.
Title: Association of tet methylcytosine dioxygenase 2 and 5-hydroxymethylcytosine in
endometrioid adenocarcinoma and its clinical significance
Version: 1 Date: 16 Aug 2023
Reviewer's report:
In this manuscript, Kuang et al. analyzed the correlation of TET2 expression and 5-
hydroxymethylcytosine (5hmC) level in endometrial cancers (ECs) to reveal the clinical
significance of TET2 and 5hmC. The authors showed that i) high levels of TET2 and 5hmC
were more common in peri-cancerous lesions than in EC tissues, ii) expression level of TET2
protein was positively associated with 5hmC level, and iii) EC patients with low levels of TET2
and 5hmC showed poor overall survival.
The authors concluded that combined detection of TET2 protein and 5hmC may be valuable for
the diagnosis and prognosis of ECs. However, the current data are not convincing enough to
support the authors' notions, for the reasons mentioned below.
Major comments:
1. The authors should carefully edit this manuscript because its structure is not well-organized.
a) The authors frequently mentioned “expression of two genes”, “5hmC protein”, and
“two proteins” throughout this manuscript. However, the TET2 protein was analyzed using
immunohistochemistry. Also, 5hmC is not a “gene” or “protein” but rather a modified form of
DNA.
b) The authors should use a professional English proofreading service because there are many
grammatical errors, both major and minor.
2. This study has very limited novelty as a previous investigation has already reported a
positive correlation between TET2 expression and 5-hmC level in ECs, along with a significant
association between low TET2 expression and poor prognosis of ECs (ref#33).
3. Figure 1. The quality of immunohistochemistry data was not suitable to distinguish the levels
of TET2 expression and 5hmC due to variations in color balance across different images.
Title: Association of tet methylcytosine dioxygenase 2 and 5-hydroxymethylcytosine in
endometrioid adenocarcinoma and its clinical significance
Version: 2 Date: 29 Dec 2023
Reviewer's report:
In this manuscript, the authors described that tet methylcytosine deoxygenase 2 (TET2)
and 5-hydroxymethyl cytosine (5-hmC) are associated with prognosis in endometrioid
adenocarcinoma. However, this reviewer has the following concerns.
1. The authors showed that the TET2 score and 5-hmC score are correlated well in Figure
2. Before showing that TET2/5-hmC cp-expression is associated with prognosis, the single
association of each TET2 and 5-hmC with prognosis should be shown, respectively. Then, a
comparison between a single item and a combination should be discussed.
2. In Table 2, the association of TET2/5-hmC co-expression with well differentiation and
negative lymph node metastasis was shown. However, the author described TET2/5-hmC co-
expression with differentiation and lymph node metastasis (lines 392-398). It might cause
misunderstanding.
Title: Association of tet methylcytosine dioxygenase 2 and 5-hydroxymethylcytosine in
endometrioid adenocarcinoma and its clinical significance
Version: 2 Date: 25 Jan 2024
Reviewer's report:
The authors have revised their original manuscript in response to the Reviewer’s comments.
However, certain issues remain unresolved.
1. As previously noted by the reviewer, considering that 5-hmC represents a modified form of
DNA, the terms such as “5-hmC expression” and “5-hmC is expressed” etc., may not be accurate.
The authors should meticulously replace “expression” with “level” and “coexpression” with
either “association” or “correlation.”
2. Although the authors mentioned that they polished their manuscript based on the comments
of professional English editors, the manuscript still lacks organization. For instance, there is
inconsistency in the usage of “5hmC” and “5-hmC”, and it is recommended that these terms be
unified throughout the manuscript.
Title: Association of tet methylcytosine dioxygenase 2 and 5-hydroxymethylcytosine in
endometrioid adenocarcinoma and its clinical significance
Version: 3 Date: 05 Feb 2024
Reviewer's report:
The authors have almost satisfactorily modified several points and added some descriptions
in the revised manuscript to address the Reviewer’s comments.  This reviewer recommends
acceptance of this revised manuscript.