Reviewer’ s report
Title: Myometrial progesterone hyper-responsiveness associated with increased risk of human
uterine fibroids
Version: 2Date: 14 Apr 2019
Reviewer: Helmer Herren
Reviewer's report:
I consider the study interesting and of good quality. The introduction, the description of the
methodology, the statistical analysis and the description of the results seemed to be adequate. Inthe discussion, I think there should be a critical analysis of the limitations of the study primarilybecause it is "in vitro". Some studies show that the gene expression pattern may be significantlydifferent in the two-dimensional environment of the "in vitro" culture and not allow adequateevaluation of the influence of the extracellular matrix on some cellular functions such as apoptosisand cellular proliferation in the development and growth of leiomyomas.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
YesDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statisticsQuality of written English
Please indicate the quality of language in the manuscript:
Acceptable
Declaration of competing interests
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