Title: Predictive Modeling of Postoperative Gastrointestinal Dysfunction: The Role of Serum
Bilirubin, Sodium Levels, and Surgical Duration in Gynecological Cancer Care
Version: 8 Date: 18 Sep 2023
Reviewer's report:
Dear Authors,
I hope this message finds you well. I would like to express my appreciation for your efforts
in revising the manuscript titled "[Unveiling Key Predictors of Postoperative Gastrointestinal
Dysfunction in Gynecological Cancer: Insights for Personalized Management Strategies]"
following the initial review. Your commitment to improving the manuscript is commendable,
and I look forward to reviewing the revised version.
Abstract:
1.lnclude specific key results in the abstract to provide a more informative summary.
2. Ensure that specific keywords are mentioned for indexing and searchability.
Introduction:
1. Explicitly state the research gap or research question.
2. Provide specific statistics or data to support claims about the prevalence of postoperative
gastrointestinal dysfunction (POGD).
3. Provide a concise review of existing literature on demographic attributes, surgical
determinants, and pre-existing conditions as triggers for POGD.
Methods:
1. Add details about the specific surgical procedures performed on the patients to provide
context.
2. Explain the rationale behind each exclusion criterion and how certain conditions or treatments
may confound the results.
3. Describe the diagnostic criteria for POGD based on clinical symptoms and interventions.
4. Specify which variables were adjusted or removed due to multicollinearity in the statistical
analysis.
5. Provide a more detailed description of the handling of missing data and the results of
sensitivity analyses.
Results:
1. Interpret the findings and discuss their clinical significance.
2. Simplify complex data with the use of visual aids like tables, graphs, or figures.
3. Explain how potential confounding variables were controlled for in the multivariate analysis.
4. Clarify whether external validation of the combined model has been conducted or planned.
5. Provide a brief guide on how clinicians can use the nomogram to assess a patient's risk of
POGD.
6. Integrate additional characteristics of case and control groups into the results discussion.
7. Discuss the clinical relevance, not just statistical significance, of the findings.
8. Ensure clarity and accessibility of language, especially for readers without a strong statistical
background.
9. Increase transparency about data source, patient selection criteria, and potential data
limitations.
Statistical Analysis:
1. Provide a detailed description of the statistical methods used in the study.
2. Explain how potential confounding variables were identified and controlled for in the
multivariate analysis.
3. Interpret the significance and implications of p-values.
4. Interpret the practical implications of odds ratios.
5. Discuss both concordant and discordant findings with existing literature.
6. Address the potential impact of a single-center study on generalizability.
7. Offer concrete suggestions for future research.
8. Discuss potential clinical implementation challenges.
9. Avoid unnecessary repetition of points.
10. Clarify the results of sensitivity analyses.
Discussion and Conclusion:
1. Explore both concordant and discordant findings in the discussion.
2. Provide nuanced interpretations of the results.
3. Address the potential impact of a single-center study on generalizability.
4. Discuss specific recommendations for future research.
5. Discuss clinical implementation challenges and strategies to overcome them.
6. Ensure clarity and conciseness in the discussion.
7. Expand on the role of surgical techniques in POGD risk.
8. Provide a thorough exploration of potential confounding factors.
9. Elaborate on biological mechanisms underlying associations.
10. Offer balanced interpretations of findings.
References:
1. Provide complete citation information for all references.
2. Ensure uniformity in citation style.
3. Organize references into categories for clarity.
4. Incorporate more recent sources.
5. Provide context for the relevance of each reference.
6. Include DOI links when available.
7. Properly identify unpublished or non-peer-reviewed sources.
8. Diversify source types.
Addressing these recommendations will enhance the overall quality, clarity, and relevance of
your manuscript.