Reviewer ’s report  
 
Title: Case report: term birth after fertility -sparing treatments for stage IB1 small c ell 
neuroendocrine carcinoma of the cervix  
 
Version: 0 Date: 24 Apr 2017  
 
Reviewer: Ahmed Hefnawy  
 
Reviewer's report:  
 
This manuscript summarizes a case report of 25 year old nulligravida with stage IB1 small cell 
neuroendocr ine carcinoma (SCNEC) of the cervix that was managed by neoadjuvant 
chemotherapy and radical abdominal trachelectomy. The patient remained disease free and had a 
successful delivery of full term baby by cesarean section 7 years later.  
 
This manuscript is interesting to the journal readership as not only it presents a rare small cell 
neuroendocrine carcinoma of the cervix but it documents the success of a multimodal therapy in 
achieving favorable oncologic and obstetric outcomes in the absence of guidelines  or consensus 
guiding management.   
 
 
Specific comments:  
 
Page 5, Lines 95 -100: HPV infection is a risk factor for Neuroendocrine Tumors. Can the 
authors clarify if the patient had any Pap smear screening before and if so, what were the results?  
 
Page 6, Lin e 108: The authors reported that the patient didn't have a paraneoplastic syndrome. 
Can they demonstrate to the readers which tests were conducted?  
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments t o the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review ? 
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manus cript:  
 
Acceptable  
 
 
 
 
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