Reviewer ’s report  
 
Title: Associations between menopausal hormone therapy and sl eep disturbance in women 
during the menopausal transiti on and post -menopause: Data from the Norwegian Prescription 
Database and the HUNT study  
 
Version: 1 Date: 07 Feb 2020  
 
Reviewer: Hamdia Ahmed  
 
Reviewer's report:  
 
The study examined the relationship between hormonal therapy during pre/menopause with sleep 
disturbance and other co -factors.  
 
General ly all section of the paper are clear and authors revised the manuscript according 
previous reviewer's comments.  
 
In introduction it is necessary to imply to the sleep related physiological changes during late 
adulthood and old age.  
 
In methods section, fi rst part, researcher mentioned that two questionnaire were used in the 
clinical field? Is these questionnaires were included in the 3rd survey, HUNT3?  
 
Figure 1 is not presented in the manuscript.  
 
Are the methods ap propriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1.  Have you in the past five years received reimbursements, fees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the future?  
 
2.  Do you hold any stocks or shares in an organisation t hat may in any way gain or 
lose financi ally from the publication of this manuscript, either now or in the 
future?  
 
3.  Do you hold or are you currently applying for any patents  relating to the content 
of the manuscript?  
 
4.  Have you received reimbursements, fees, funding, or salary from an organiz ation 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
 
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below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
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