JerMa88/BMC_Womens_Health_Peer_Reviews huggingface dataset:
Title: HMOX1: A Pivotal Regulator of Prognosis and Immune Dynamics in Ovarian Cancer
Version: 4 Date: 18 Jul 2024
Reviewer:  Phuc Nhon Nguyen
Reviewer's report:
Dear authors,
Thank you your great work on women’s health. The research adds a novel insights concerning
the heme oxygenase-1 (HMOX1, HO-1) enzyme  in prognosis of ovarian cancer and the
underlying treatment of immunotherapy. However, the paper has some concerns:
-Due to the data collection, the study only focused on genetique factor. The baseline
characteristics including age, BMI, concomitant diseases, morphologic features of ultrasound
findings were absent.
-The study enrolled 371 patients with high-grade ovarian serous carcinoma. Thus, the role of
HMOX1 was only found in this population. Other type of ovarian cancer and differentiated
grade was not investigated.
-Although the study purposes to explore the multifaceted role of Heme Oxygenase 1 (HMOX1)
in ovarian cancer, however, multivariate logistic regression was not used to analyze the relating
factor.
- HMOX1 was found to significantly modulate the infiltration of immune cells, notably
neutrophils and macrophages. However, the study lacks of control group to compare. Other
physiopathological conditions and other types of cancers are considered. Please read these
papers:
+Consoli V, Sorrenti V, Grosso S, Vanella L. Heme Oxygenase-1 Signaling and Redox
Homeostasis in Physiopathological Conditions. Biomolecules. 2021;11(4):589. Published 2021
Apr 16. doi:10.3390/biom11040589.
+ Chiang SK, Chen SE, Chang LC. The Role of HO-1 and Its Crosstalk with Oxidative
Stress in Cancer Cell Survival. Cells. 2021;10(9):2401. Published 2021 Sep 13. doi:10.3390/
cells10092401
-How the study could apply HMOX1 in an overian cancer with and without inflammation.?
Please refer to this document: Campbell, N.K., Fitzgerald, H.K. & Dunne, A. Regulation of
inflammation by the antioxidant haem oxygenase 1. Nat Rev Immunol 21, 411–425 (2021).
https://doi.org/10.1038/s41577-020-00491-x
- The clinical survival data such as overall survival (OS), postprogression survival (PPS), and
progression-free survival (PFS) may be affected by multiple factors, not only HMOX1.
-The study applier  Kaplan Meier survival curves and log-rank test as well as the Spearman
correlation between 2 variables. However, these were not mentioned in Statistical analysis.
-Please provide the strengths and limitations of the study.
-Conclusions needed to be clarified by a separate paragraph.
-Some other minor points:
+The number of figures is excessive. Please provide as supplementary files following journal’s
instruction.
+Please delete the Chinese word in Figure 9.
+Full-word should be provided to Figures as a footnote.
+English editing is required.
Best regards,
Title: HMOX1: A Pivotal Regulator of Prognosis and Immune Dynamics in Ovarian Cancer
Version: 4 Date: 19 Jul 2024
Reviewer's report:
I read with great interest the Manuscript titled " HMOX1: A Pivotal Regulator of Prognosis and
Immune Dynamics in Ovarian Cancer”, topic interesting enough to attract readers' attention.
Although the manuscript can be considered already of good quality, I would suggest following
recommendations:
- I suggest a round of language revision, in order to correct few typos and improve readability.
- Considering the topic analyzed and state of the art in literature, the authors could extend
and improve the discussion by evaluating and citing current evidence about possible target
therapeutic strategies for patients with ovarian cancer.  I would be glad if the authors discuss
this important point, referring to PMID: 37314974.
- Various mutations, i.e. RAS-RAF-MEK-ERK pathway, had been detected and several
inhibitors of this pathway have been developed, whose antitumor potential is currently being
assessed in different clinical trials. Considering results and topic of this study, I suggest
reading and adding references about recent evidence with the aim to improve prognosis and the
possibility of tailored management. I would be glad if the authors discuss this important point,
referring to PMID: 38768941.
Because of these reasons, the article should be revised and completed. Considering all these
points, I think it could be of interest to the readers and, in my opinion, it deserves the priority
to be published after minor revisions.
Title: HMOX1: A Pivotal Regulator of Prognosis and Immune Dynamics in Ovarian Cancer
Version: 4 Date: 21 Jul 2024
Reviewer's report:
the article presents in a comprehensive manner the possibility of adding heme oxygenase-1 as
a potential biomarker and a therapeutic target against ovarian cancer. The isssue is particularly
important due to the fact that, despite progress has been made, ovarian cancer remains a
significant cause of death among women worlwide.
Title: HMOX1: A Pivotal Regulator of Prognosis and Immune Dynamics in Ovarian Cancer
Version: 5 Date: 27 Jul 2024
Reviewer's report:
Thank you for giving me the opportunity to review this interesting study "HMOX1: A Pivotal
Regulator of Prognosis and Immune Dynamics in Ovarian Cancer".
Almost all reviewer’s comments and recommendations were considered.
Title: HMOX1: A Pivotal Regulator of Prognosis and Immune Dynamics in Ovarian Cancer
Version: 5 Date: 28 Jul 2024
Reviewer:  Phuc Nhon Nguyen
Reviewer's report:
Dear authors,
Thank you for addressing all my concerns.
The paper is well improved now.
However, some Chinese words remain present in manuscript (before value of 150-250 um in
Fig 7). Please check and replace it by English words.
Aside from my opinion, I have no more concerns.
Congratulation on your great contribution  concerning novel marker (HMOX1) in ovarian cancer
to the literature gap.
Best regards,
Phuc Nhon NGUYEN MD
Tu Du Hospital, Ho Chi Minh City, Vietnam
Title: HMOX1: A Pivotal Regulator of Prognosis and Immune Dynamics in Ovarian Cancer
Version: 6 Date: 11 Aug 2024
Reviewer:  Phuc Nhon Nguyen
Reviewer's report:
Dear authors,
Thank you again for your revised paper.
The content is clear now. Thus, I have no more comments.
Congratulation on your research.
Best regards,
Phuc Nhon NGUYEN MD
Tu Du Hospital, Vietnam
Title: Predictors of Enrollment in a Virtual Diabetes Prevention Program Among Women
Veterans: A Retrospective Analysis
Version: 1 Date: 03 Jul 2024
Reviewer's report:
This is a timely and interesting analysis of predictors of participation in virtual DPP
programming in female Veterans. With some additional details added, this manuscript will
provide  insight into future efforts in the VA healthcare system.  My review comments are
attached.
Title: Predictors of Enrollment in a Virtual Diabetes Prevention Program Among Women
Veterans: A Retrospective Analysis
Version: 1 Date: 18 Jul 2024
Reviewer's report:
Overall this is a well-written manuscript that clearly describes the methods and differences
between women Veterans who chose to enroll vs. those who did not in a virtual diabetes
prevention program. The feedback for the authors is relatively minor.
First, women who were excluded from this study because they otherwise eligible but were
not contacted were a potential concern. If this was a rare occurrence, consider stating in the
manuscript. If there were a notable % of cases in which this occurred, please list as a limitation
as this could be a separate process that impacts enrollment.
Results may be overstating impact of "SDOH" given they just have one, housing instability.
In general, replacing a single cell in a column with "<10" when totals are known is not sufficient.
Additional steps are required in order to mask those values.
Minor edits:
page 7 line 146: should this read "Veterans'"?
Table 1, round the overall % in the first row to 1 decimal, consistent with the other numbers.
Consider if additional clarification is required for VA-specific terms/data elements:
VA clinic stop codes
Health Factors
Service connected disability
Title: Predictors of Enrollment in a Virtual Diabetes Prevention Program Among Women
Veterans: A Retrospective Analysis
Version: 3 Date: 09 Aug 2024
Reviewer's report:
The authors have made significant revisions to the manuscript and it is much strengthened
as a result. I do not believe additional major changes are warranted. I would suggest that the
authors consider adding a sentence or two to the Conclusions describing the implications for
DPP programming of finding that Veterans were more likely to respond to an increased number
of recruitment contacts.  It may indicate that the VA needs to reconsider the standard approaches
to advertising these programs and enrolling Veterans.
Title: Vitamin D Levels and Lipid Profiles in Patients with Polycystic Ovary Syndrome
Version: 1 Date: 12 Mar 2024
Reviewer's report:
1)  Please explain the research question and aim of the study in background.
2)Please explain briefly the impact of vitamin D on lipid profiles in PCOS.
3) Please mention the prevalence of PCOS in background.
4)The last paragraph of the background needs revision.
5)Why did you select 1004 women with PCOS in your study?
6)Please mention, how long has not taking vitamin D supplements been one of the exclusion
criteria?
7) Line 105, Methods and materials, is not clear.
8) Please explain the laboratory measurements in more details.
9) why did you prefer correlation method over regression method in statistical analysis?
10)which variables were adjusted?
11) In table 1, why are the data presented as median?
12) Please explain the infertility diagnosis criteria?
13) Why didn't you report TC in table 1 and 2?
14) Please mention the strengths of your study in discussion.
15)Discussion part needs more scientific evidence, please revise this part.
Title: Vitamin D Levels and Lipid Profiles in Patients with Polycystic Ovary Syndrome
Version: 2 Date: 19 Jun 2024
Reviewer's report:
Dear Authors
I recently had the opportunity to review your study titled "The Relationship between Vitamin D
Levels and Lipid Profiles in Women with Polycystic Ovary Syndrome." I found the study to be
well-conducted and informative, and I appreciate the effort you and your team put into it.
I did notice that the study did not include a subgroup analysis based on the PCOS phenotype,
which I believe could provide valuable insights into the relationship between vitamin D
deficiency and lipid profiles in different subgroups of PCOS patients. Specifically, I think it
would be interesting to see how vitamin D levels correlate with lipid profiles in patients with
different PCOS phenotypes, such as those with hyperandrogenism or polycystic ovaries.
Would it be possible to perform this subgroup analysis and include the results in a future
publication or update? I believe this would enhance the study's overall impact and provide more
comprehensive insights into the relationship between vitamin D and lipid profiles in PCOS
patients.
Thank you for considering my request. I look forward to hearing back from you.
Best regards
Title: Vitamin D Levels and Lipid Profiles in Patients with Polycystic Ovary Syndrome
Version: 4 Date: 13 Jul 2024
Reviewer's report:
Thank you for the corrections you made and I also appreciate the effort you and your team put
into it.
I am interested to know why are the data presented as median? And What are the infertility
diagnosis criteria?
You did not explain clearly why a significant correlation was observed between vitamin D levels
and HDL among the overweight or obese subgroup?
Title: A Report of Twenty Cases of Ovarian Brenner Tumor and Literature Review: A Case
Series Study
Version: 0 Date: 12 May 2024
Reviewer:  Basilio Pecorino
Reviewer's report:
Dear Author, thanks for the opportunity to review this manuscript.
Review article must be registered on PROSPERO system: https://www.crd.york.ac.uk/prospero/
Suggested citations:
La Spina S, Scollo P, Pecorino B, Lombardo V, Motta A, Calderone RG, Calì S, Lipari H,
Scandurra G. Life Experience of Survivors of Gynecologic Cancers: A Survey Conducted in
Italy. Oncology (Williston Park). 2024 Jan 9;38(1):15-19. doi: 10.46883/2024.25921012.
Title: A Report of Twenty Cases of Ovarian Brenner Tumor and Literature Review: A Case
Series Study
Version: 0 Date: 15 Jul 2024
Reviewer's report:
The article presents in a very well documented manner the diagnosis and therapeutic challenges
in ovarian Brenner tumors, a rare entity diagnosed in women at every age. The strength of the
manuscript consists of the relatively high number of patients and of the good documentation of
each case, give the fact that these tumors are rather scarce
Title: Impact of Ultrasound-guided High-intensity Focused Ultrasound for the Treatment of
Uterine Fibroids on Ovarian Reserve and Quality of Life: A Single-center Prospective Cohort
Study
Version: 1 Date: 14 Jul 2024
Reviewer's report:
Several previous studies have shown that USgHIFU significantly reduces fibroid size and
alleviates symptoms such as heavy menstrual bleeding and pelvic pain. The authors report a
prospective analysis of 54 cases focusing on ovarian reserve and quality of life.
The manuscript is adequately written, however there are some insights reported below
- Previous studies indicates that USgHIFU has no significant impact on ovarian reserve. In a
study involving 84 patients with uterine fibroids, no significant changes were observed in the
AMH levels before and six months after treatment. (Qu K, et al. The impact of ultrasound-guided
high-intensity focused ultrasound for uterine fibroids on ovarian reserve. Int J Hyperthermia.
2020). This analysis reports the same results with more patients (84 versus 54).  Probably set
up this study as a case-control study, (uterine artery embolization, EAU versus HIFU) would
have been innovative.
- Follow up is limited. Would it be possible to wait 12 -18 months post-procedure? this would
represent a long term follow up, a new scenario in literature.
- A limitation on AMH levels is related to the fact that it decreases with age. When age is > 45
years, AMH levels are so low that it’s difficult to suppose that HIFU having an impact. If patients
< 45 years (20+21) are combined, does the comparison of AMH assume statistical significance?
It would be interesting to have larger numbers on patients <40 years, where the impact of the
HIFU on ovarian preservation may be of more interest.
Title: Impact of Ultrasound-guided High-intensity Focused Ultrasound for the Treatment of
Uterine Fibroids on Ovarian Reserve and Quality of Life: A Single-center Prospective Cohort
Study
Version: 1 Date: 20 Jul 2024
Reviewer's report:
I read the manuscript with great interest, which falls within the aim of this journal and offers a
high-quality overview of the topic.
The abstract satisfactorily summarizes the contents of the manuscript. The methodology is
accurate and the data analysis supports the conclusions. The tables are clear and interesting.
Although the manuscript can be considered already of high quality, I would suggest taking into
account the following minor recommendations:
- I suggest another language revision round to correct typos and improve readability.
-The introduction should be extended and completed I find it interesting to include a reference
to the differential diagnosis of uterine malignancies discussing the current tool used for the
assessment of uterine sarcomas (see PMID: 37348383).
-What are the implications of these findings for clinical practice and/or further research? It is
important to report the results obtained by the authors in the context of clinical practice and to
adequately highlight what contribution this study adds to the existing literature on the topic and
future study perspectives.
- The authors have not adequately highlighted the strengths and limitations of their study. It
would be better to explain these points.
Title: Impact of Ultrasound-guided High-intensity Focused Ultrasound for the Treatment of
Uterine Fibroids on Ovarian Reserve and Quality of Life: A Single-center Prospective Cohort
Study
Version: 3 Date: 09 Aug 2024
Reviewer's report:
Thank you for going through the manuscript and the reviewers' points
Honestly, the authors have responded satisfactorily to the reviewers’ criticisms.
The manuscript is well written and falls within the aim of this Journal.
Title: Prognostic effect of the pretreatment prognostic nutritional index in cervical, ovarian, and
endometrial cancer: A meta-analysis
Version: 1 Date: 03 Jul 2024
Reviewer:  Muhammed Ashraful Alam
Reviewer's report:
Topic is good as well as important.
Selected studies were mostly taken from Asian region (China, Japan, India etc.). Regional
variations could be minimized through choosing articles from across the world. This issue should
be included in the limitations.
Study design from each selected article could be included in the table.
Title: Prognostic effect of the pretreatment prognostic nutritional index in cervical, ovarian, and
endometrial cancer: A meta-analysis
Version: 1 Date: 07 Jul 2024
Reviewer's report:
The manuscript investigates the prognostic significance of the pretreatment prognostic
nutritional index (PNI) in cervical, ovarian, and endometrial cancer through a meta-analysis.
The study includes 28 articles involving 9,428 patients. The results demonstrate that low PNI is
associated with worse overall survival (OS), progression-free survival (PFS), and disease-free
survival (DFS) in gynecological cancers. The meta-analysis also includes subgroup analyses to
confirm these findings across different cancer types and patient characteristics. The manuscript
provides valuable insights into the prognostic role of PNI in gynecological cancers, supported by
rigorous meta-analytical methods. With minor revisions to enhance clarity and discussion, this
study has the potential to make a significant contribution to the field and inform clinical practice.
My recomendations for Improvement:
1. I would suggest including more in-depth discussion on the heterogeneity observed among
studies and potential strategies to address this in future research.
2. Please, try to discuss the implications of PNI as a prognostic tool in clinical practice, including
its integration with existing prognostic indicators and potential for guiding treatment decisions.
3. I would suggest considering to perform a meta-analysis on the impact of PNI on specific
cancer types separately if data allows, to provide more targeted insights.
4. Please try to explore the interaction between PNI and other clinical variables such as tumor
grade and stage in more detail.
5. Please integrate findings from related fields, such as the prognostic value of PNI in other
cancers, to provide a broader context for the study's findings.
Title: Prognostic effect of the pretreatment prognostic nutritional index in cervical, ovarian, and
endometrial cancer: A meta-analysis
Version: 3 Date: 31 Jul 2024
Reviewer:  Muhammed Ashraful Alam
Reviewer's report:
"Finally, this study was limited to English-language published studies. Thus, potential
publication bias could not be completely avoided".....it's not an important issue for an article
written in English and it should be better to delete this line.
Title: Promoting gender equity in a home visits programme: A qualitative study in Northern
Nigeria
Version: 1 Date: 18 Dec 2023
Reviewer's report:
Overall, the manuscript is interesting and gave out information on an important topic. Impacting
gender norms in Africa especially around maternal and child health is a timely topic. The
manuscript corroborates support previous researches and lead to strengthen evidences that future
interventions will need to better impact gender norms in Sub-Saharan Africa.
Some revisions are needed before the manuscript can be published:
- Specify exactly the sample size of the research: total number of participants in the different
FGDs
- Include the questionnaire/interview questions and the conceptual framework in the annexes
- The writers need to provide more information on the home visits after delivery:  how long
(days) after delivery was the visit done? And how many time after delivery?
- Method:
"The team  designed focus group discussions and individual interview guides" - what team?
Who compose the team?
"Bauchi State PHDCA"  - definition of PHDCA
What was the purpose of the FGD for the local research team?
- Discussion :
"The effect on decision-making was more complicated, with some focus group participants
suggesting that increasing men’s knowledge and improving their attitudes were important
because “they are the decision-makers.” Even groups reporting increased involvement of women
in decision-making reported this only in relation to health and health service use, which confirms
findings from other studies . " - Does it mean the programme did not really impact the participants
views on decision-making?
"Our participatory approach engaged men from the programme's beginning and considered them
partners in seeking solutions to address maternal morbidity and mortality."  - Do not understand
this sentence, pease check sentence construction
- In the discussion part, when citing other studies, make sure to highlight exactly their findings
your manuscript also supports and found
- Limitations : Other limitations might be FGDs were not recorded, so the information collected
solely depends on the reporter (note taker) and possible social desirability bias
- Check the sentences construction and grammar, some sentences could be written better to help
the reader understand easily
Title: Promoting gender equity in a home visits programme: A qualitative study in Northern
Nigeria
Version: 1 Date: 19 Dec 2023
Reviewer's report:
The paper was well written and made for an interesting read. It covered an important topic on
promoting gender equity in health and health decision-making. The authors should consider the
points below to strengthen the paper:
What do the authors consider to be a gender transformative program? A definition for the
purposes of this paper will be helpful as that term ahs been defined in various ways depending
on the context.
Introduction, Third paragraph: The mention of community based programs doesn't have
an adequate context. Sure, the impact of gender inequalities and healthcare access is not
documented, but how is that tied directly to community based programs? That is not fleshed out.
In the same paragraph, the author refers to "compelling evidence" from a 2014 review on gender-
integrated intervention but it is not clear what the evidence is. Perhaps consider restructuring
the sentence.
Did one focus group occur in each community? If so it doesn't add up
Since qualitative research is often inherently inductive, could you provide a justification for
using only deductive analysis? It is clear from your results that you did not stick to predefined
categories on division of labour, access to resources and decision-making, so It is unclear why
the decision to use a deductive analysis.
Financial empowerment grants women financial independence and power over financial
resources and ideally financial decisions.
Starting a business can be considered financial empowerment, but it is difficult to justify the
thought that husbands giving their wives money for hospital visits and feeding empowers women
financially.  In this case, the husbands still wield control over financial resources. Consider
revising the statement and corresponding quote to reflect the accurate description of financial
empowerment
The limitation section should include a thoughtful reflection on what could be improved on. For
example,  include limitations of using a deductive analysis and the possibility of being limited
by the quality and quantity of your data, being prone to errors or biases in predefined structuring
of the work, and being unable to explain how unexpected or novel findings were incorporated.
How much did the authors consider the influences of faith in gender relations? Were faith-based
leaders consulted in undertaking his program? It is my understanding that Bauch is an area of
religious pluralism, with Islam and Christianity both having a strong presence. The majority of
the population is Muslim but there is also a substantial indigenous Christian minority.