Reviewer’s report
Title: 
CCDC114, DNAI2 and TOP2A  involves in the effects of Tibolone
treatment on postmenopausal endometrium
Version: 
2 
Date: 
07 Nov 2020
Reviewer's report:
'epirubicin may have potential as a clinical alternative to tibolone to target
TOP2A'
It is still not clear as to the role of epirubicin in this case. You are discussing
tibolone as hormone replacement therapy, have outlined well the benefits vs
estrogen/progesterone, 
and discussed the mechanism of actions - yet suggesting
a drug used to treat cancer can be an alternative to tibolone
Needs to be clearer in what clinical sense would Epirubicin be a better
alternative to tibolone?
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