Reviewer’s report
Title: Hyaluronan-binding protein 2 (HABP2) gene variation in women with recurrent miscarriage
Version: 0 Date: 04 May 2017
Reviewer: Alaa El-Din Mahmoud Ismail Mahmoud
Reviewer's report:
Please include all comments for the authors in this box rather than uploading your report as an  
attachment. Please only upload as attachments annotated versions of manuscripts, graphs, supporting  
materials or other aspects of your report which cannot be included in a text format.
Please overwrite this text when adding your comments to the authors.
dear sir i have a great honor to review this paper of you respectable journal,and i am sorry for delay in  
response.Her are my reviewing comments.
Originality of the paper: It not original.
Writing language : good.
Design:fair.
Sample size:is not powered and the arms are not equal and this makes the analysis is not correct ,also  
there is a difference between the number of the RM group in the abstract (189 cases) and in the table it  
is 165 cases statistics.ONLY one table for the study ?? this make the study is very week.Also no  
sciodemogarphic data fo the study groups.When to say figure 1 you should have figure 2 and when to  
say table 1 you should have table 2 ;this was not mentioned in the paper as it contain only one figure  
and one table.
Methods:Fair.I am wondered about this long period of the study 
(about 20 years) and only this small number of the patients? .i think this long period and the same  
method for detection of gene polymorphism? 
Conclusion:The end point of the study is different from the aim of the study.  
 MY Decision is : Rejection of this paper  as there are many major issues:
   1- It add no new for the known about Hyaluronan-binding protein 2 (HABP2) gene variation in  
women with recurrent miscarriage.
   2-methodological and statistical points of view .
Thanks
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
No
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
No
Are you able to assess any statistics in the manuscript or would you recommend an additional  
statistical review?
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Not suitable for publication unless extensively edited
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation  that  may  in  any  way  gain  or  lose  financially  from  the  publication  of  this  
manuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose financially  
from the publication of this manuscript, either now or in the future?
3. Do  you  hold  or are  you  currently applying  for  any patents  relating  to  the  content  of  the  
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds or  
has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?
6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below. If  
your reply is yes to any, please give details below.
'I declare that I have no competing interests
I agree to the open peer review policy of the journal. I understand that my name will be included on my  
report to the authors and, if the manuscript is accepted for publication, my named report including any  
attachments I upload will be posted on the website along with the authors' responses. I agree for my  
report to be made available under an Open Access Creative Commons CC-BY license  
(http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments which I do not wish to  
be included in my named report can be included as confidential comments to the editors, which will not  
be published.
I agree to the open peer review policy of the journal