JerMa88/BMC_Womens_Health_Peer_Reviews huggingface dataset:
Title: Outcomes following conization and factors on HPV regression among young females in
Wuxi
Version: 1 Date: 09 Apr 2025
Reviewer:  Shi-Hao Huang
Reviewer's report:
Major Comments
1. Ambiguity of “duration of sexual history”: The term “duration of sexual history” is vague and
lacks definition. It is unclear whether it refers to age at first intercourse, total years of sexual
activity, or number of sexual partners. - Recommendation: Provide a precise definition of this
variable and consider its limitations. If not adjusted for number/frequency of partners, please
confirm this in the limits.
2. HPV clearance rates not quantified in this section: You state that the HPV clearance rates you
observed were lower than others, but do not provide the actual percentages from your study in
the body of the Discussion. - Recommendation: Clearly report your observed clearance rates
(e.g., “Our 24-month clearance rate was 72%…”) to allow for meaningful comparison with the
cited studies.
3. HPV vaccination interpretation requires nuance: The statement that HPV vaccination does not
significantly reduce persistence may be misleading if the timing of vaccination and prior HPV
exposure are not taken into account. - Recommendation: Clarify that vaccines are preventive
and vaccination after infection may result in low effectiveness. Furthermore, low coverage and
small sample size are discussed as limiting explanations.
4. Repetition of key themes: The impact of sexual history and condom use was discussed in
multiple sections with similar content. - **Suggestion**: Combine overlapping content into one
concise paragraph to improve flow and avoid redundancy. -
Small Comments
1. Structure and flow: The subheadings are quite descriptive, but some sections could be better
integrated (e.g., “Factors influencing HPV clearance” and “Sexual history, condom use…”). -
Recommendation: Combine overlapping ideas under more comprehensive topic headings.
2. Data interpretation: “Our study did not identify a significant protective effect of HPV
vaccination…” may give a wrong impression to readers who are not familiar with confounding
factors. - Recommendation: Consider milder language, such as “We did not observe a
statistically significant effect of vaccination, possibly due to…”.
3. Global comparison section: This section effectively compares global HPV regressions but
does not take into account genotypic variation or cultural practices. -Recommendations: Briefly
mention that regional differences in HPV genotype distribution and sexual behavior may affect
the results.
Other suggestions - Consider including a graphical abstract or table comparing your HPV
clearance rates with those of international studies (if your target journal allows this). - It may
be beneficial to briefly speculate on the mechanisms of reinfection after conization in sexually
active women – this may be valuable for the reader and for framing future research.
Title: Outcomes following conization and factors on HPV regression among young females in
Wuxi
Version: 1 Date: 10 Apr 2025
Reviewer:  Danilo Aravena-Nazif
Reviewer's report:
To the authors
Greetings.
The article is well written and the topic is very interesting for health care providers and the
scientific community. I have some comments. Please see the attached file.
Line 104. HSIL and LSIL are well known abbreviatures but I recommend to define them first.
Line 101. Study design and population. The authors do not show any information about the
sampling method used for the subject selection. Also, no statistical power calculation is available
making difficult to understand why 400 women were selected for the study.
Line 138. No information about the normality test used in the statistical analysis.
Lines 198 and 199. Cervical intraepithelial neoplasia abbreviature already mentioned in line 55.
Line 243. Without information about statistical power or the number of eligible subjects in
relation to the total population is difficult to determine if the sample size is small. Maybe
suggesting a multi-center study instead of a large cohort could be a better option?
Title: Outcomes following conization and factors on HPV regression among young females in
Wuxi
Version: 1 Date: 12 Apr 2025
Reviewer:  Zeena Raad Helmi
Reviewer's report:
Dear Author,
Thank you for the opportunity to review the manuscript entitled “Outcomes following conization
and factors on HPV regression among young females in Wuxi”
Comments:
1-results seemed a bit disorganized and scattered.
2-“It seems that the study did not address the details in depth regarding how the timing of first
sexual activity affects HPV status.
3- what was the presentation of the study group ?
4-all the patients involved in the study were histologically confirmed with LSIL/HSIL?
Title: Outcomes following conization and factors on HPV regression among young females in
Wuxi
Version: 3 Date: 24 Apr 2025
Reviewer:  Danilo Aravena-Nazif
Reviewer's report:
Line 134: again, the normality test type is no specified (ie. Shapiro-Wilk, Kolmogorov-
Smirnov). Also, the correct words are "normality test", not "normal test".
Title: Depression, Anxiety, and Stress among Mothers of Children with thalassemia in
Bangladesh: A cross-sectional study
Version: 1 Date: 30 Jun 2024
Reviewer's report:
It is better to state the type of study at the end of the title.
A cross-sectional study
It is better to bring the global statistics of patients with thalassemia major.
What were the inclusion and exclusion criteria for the study?
The text description of the results is many. Please write more briefly.
What about the psychological conditions of the people participating in the study?
Title: Depression, Anxiety, and Stress among Mothers of Children with thalassemia in
Bangladesh: A cross-sectional study
Version: 1 Date: 02 Jul 2024
Reviewer's report:
First of all, thank you very much for inviting me as a reviewer for this study. The research topic
is current and makes important contributions to the literature. However, I would like to make
a few suggestions to the research.
The patient selection is very good and the number of mothers is sufficient, but I do not understand
where the three people added at the end came from and why they were added.
The findings section is discussed in detail. However, it is not discussed with the current literature.
It needs to be supported with current research.
In the summary section, it should be added how many mothers the research was conducted with.
It would be better if the results of the regression analysis in the findings section are added.
Title: Effects of Family Planning Education Given to Married Illiterate Women of Reproductive
Age via Visual Material Support on Family Planning Related Attitudes and Contraceptive
Preferences: The Example of Viran#ehir, Türkiye
Version: 1 Date: 16 Mar 2025
Reviewer's report:
1.The author applies only a limited set of essential rules in the implementation of the
experimental design.
2. Kindly review the methodology section once more, ensuring full adherence to all mandatory
research guidelines, and provide justifications to support your approach.
3. Please provide a detailed report on the validation process, particularly concerning the newly
developed self-designed instrument.
4. The control group did not receive any intervention, unlike the treatment group, which led to
the observed ‘significant’ findings—however, this interpretation is incorrect.
5. Kindly refer to the attached manuscript review for further insights.
Title: Effects of Family Planning Education Given to Married Illiterate Women of Reproductive
Age via Visual Material Support on Family Planning Related Attitudes and Contraceptive
Preferences: The Example of Viran#ehir, Türkiye
Version: 1 Date: 17 Mar 2025
Reviewer:  Fatma #ule Bilgiç
Reviewer's report:
Dear Authors,
I congratulate you on your study. I believe that a detailed examination of the study will contribute
to the practices and literature of the country where the study was conducted and countries
with similar conditions. I believe that all parts of the study are sufficient and have been done
meticulously.
Best wishes,
Title: The impact of reproductive health needs on women’s employment: a qualitative insight
into managing endometriosis and work
Version: 3 Date: 20 Feb 2025
Reviewer's report:
Thank you for your contribution in this research article. Please find my below feedback.
Background
1) Important to highlight that endometriosis affects people – gender inclusive language with the
first sentence, “Endometriosis and adenomyosis are reproductive health conditions that affect
about 10 per cent of reproductive-age women”.
2) I would recommend listing some of the side effects to give the reader a better picture –
“In addition, treatments for endometriosis and adenomyosis are seldom successful or without
adverse side-effects.”
Material and methods
1) Under participants – it is not clear what is meant by “who identified as a woman” – they were
women? Cisgender women?
Results
1) I thought it was meaningful that there were many quotes to illustrate women’s lived
experience.
Discussion and conclusion
1) As this article actively discusses policy, have authors thought about sharing this article or
an open letter to government to inform policies? Or how will authors create awareness of their
research and their participants lived experience other than publishing this valuable article?
Title: The impact of reproductive health needs on women’s employment: a qualitative insight
into managing endometriosis and work
Version: 5 Date: 01 Apr 2025
Reviewer's report:
Dear Authors,
I read your paper with great interest. Endometriosis and adenomyosis are chronic diseases of
reproductive age that have a significant impact on women's quality of life. Both the painful
symptoms and the impact on fertility have an important impact on the physical and mental health
of these young women.
It is certainly a laudable aim to underline the need for support for these patients in their social
life and in the world of work.
The main limitation of the study is the small sample.
To improve the article I suggest:
-emphasizing the importance of early diagnosis for both endometriosis and adenomyosis, since
starting an adequate management can reduce both the worsening of the painful symptoms and
the impact on fertility (it may be useful this recent paper: doi: 10.3390/diagnostics14212344.)
-emphasizing the need for reference centers for the management of these patients from a young
age (it may be useful this recent paper: doi: 10.1016/j.jmig.2023.03.017.)
-the importance of a multidisciplinary approach that includes different professional figures
Best Regards
Title: Effects of a web-based decision aid on the breast cancer patients considering a breast
reconstruction: A randomized controlled trial
Version: 2 Date: 09 Mar 2025
Reviewer:  Sadi Elasan
Reviewer's report:
Thank you for submitting your manuscript titled “Effects of a web-based decision aid in
breast cancer patients considering breast reconstruction: A randomized controlled trial.” I have
carefully reviewed your work, particularly focusing on the statistical analyses, and found them
to be appropriate and clearly reported. Your work is a valuable contribution to the field and I
believe it will be of great interest to readers.
Title: Effects of a web-based decision aid on the breast cancer patients considering a breast
reconstruction: A randomized controlled trial
Version: 2 Date: 17 Mar 2025
Reviewer's report:
Commendations on the experiment. The results are interesting. However, the quality of the
manuscript requires considerable improvement before consideration for publication.
Specific concerns: Grammar is poor throughout. Furthermore, there are several spelling errors.
Some acronyms are not defined, such as BCP. Symbols are not defined in the section on
sample size. Given the use of Likert scales with fixed minimum and maximum possible
values, confidence intervals should be given rather than standard deviations in table 2. Table
headings should be repeated on each new page. Table formatting is poor, with figures and text
unnecessarily running over multiple lines.
The questionnaires used should be supplied as an appendix. Please state what the maximum
possible score is for each domain.
Please explain the risks of breast reconstruction in the introduction.
“Web-based decision aids (WDAs) are interactive tools to help patients make informed
decisions , and relevant studies have not been conducted in China” – relevant studies examining
what? Please clarify in text.
“According to the intervention research formula to calculate the sample size: n1=n2=; According
to the table…” – what table? Please clarify in text.
“Refered to relevant literature,” – citations are missing.
“Patients can use fragmented time…” – what is fragmented time? Please clarify in text.
Title: Psychological traits associated with anabolic androgenic steroid use and dependence: an
exploratory cross-sectional study among female athletes
Version: 3 Date: 17 Oct 2024
Reviewer:  Lukas Andreas Basedow
Reviewer's report:
I commend the authors for their professional and comprehensive reply. They took care to adress
all of my concerns in a suitable manner. Thus I have no further concerns or objections.
Title: Psychological traits associated with anabolic androgenic steroid use and dependence: an
exploratory cross-sectional study among female athletes
Version: 3 Date: 24 Oct 2024
Reviewer's report:
I congratulate the authors for the substantial improvements they have made to the manuscript
based on the reviewers' suggestions. However, I suggest that they make one last minor change
before potential publication of their work:
To follow the line of the usual methodological sections of the journal, it would be convenient
to create a section on study design at the beginning of the methods section, including the
information in the first sentence of the procedures subsection: "This study uses data from a larger
mixed-methods study investigating brain and psychological aspects associated with use of AAS
at Oslo University Hospital". After the new design section, they should include the new section
on participant characteristics that they have included at the beginning of the results section with
its table. Then the measures section would be included as it is, and after this the procedures
section would be included with the sentence indicated for the design section eliminated and
included alone in the new design section.
I hope these suggestions contribute to enhancing the quality of the work.
Title: A Rare Case of Malignant Transformation: Squamous Cell Carcinoma Arising on the
Basis of an Ovarian Mature Cystic Teratoma
Version: 2 Date: 17 Feb 2025
Reviewer's report:
Dear authors, the malignant potential of mature cystic teratoma is an important detail that
should always be kept in mind. Multidisciplinary approach and radiology collaboration are very
valuable in this case. Although its innovative contribution to the literature in terms of articles is
not much, it is explained in a simple and fluent language that is quite sufficient as a case report.
Adding the reference suggested in the discussion section will strengthen the article. Kind regards
Sahin F, Aktürk E, Günkaya OS, Özdemir S, Konal M, Genç S, Yurci A, Akbayir O. Borderline
ovarian tumors: twenty years of experience at a tertiary center. Anatolian Curr Med J / ACMJ /
acmj. July 2023;5(3):196-200. doi:10.38053/acmj.1243317
Title: A Rare Case of Malignant Transformation: Squamous Cell Carcinoma Arising on the
Basis of an Ovarian Mature Cystic Teratoma
Version: 2 Date: 18 Feb 2025
Reviewer's report:
Thank you for giving me the opportunity to review this interesting study "A Rare Case of
Malignant Transformation: Squamous Cell Carcinoma Arising on the Basis of an Ovarian
Mature Cystic Teratoma".
However, I have some comments and recommendations:
Comments:
Title: - Is appropriate for the content of the article.
Abstract:- Represents a suitable summary of the work.
Case:- The methods and results have been well explained.
Conclusions:- Are justified on the basis of the study.
Recommendations:
References:- Stick to the format of the journal.
General:- Revise language, grammar and syntax.
Title: A Rare Case of Malignant Transformation: Squamous Cell Carcinoma Arising on the
Basis of an Ovarian Mature Cystic Teratoma
Version: 2 Date: 10 Mar 2025
Reviewer:  Ebenezer Senu
Reviewer's report:
The study looks relevant and could add knowledge to the scientific literature; However,
the present figures lack key information.
Authors should present detailed caption about each figure. Dimensions or magnifications of each
figure should be presented.
Does authors also have the final histopathological examination slides  if they did any H & E
staining that revealed squamous cell carcinoma? They could submit that too
Overall, the write up looks ok
Title: A Rare Case of Malignant Transformation: Squamous Cell Carcinoma Arising on the
Basis of an Ovarian Mature Cystic Teratoma
Version: 2 Date: 17 Mar 2025
Reviewer:  Irene Pelayo-Delgado
Reviewer's report:
The article entitled “A Rare Case of Malignant Transformation: Squamous Cell Carcinoma
Arising on the Basis of an Ovarian Mature Cystic Teratoma” illustrates an interesting  case report
of  an ovarian carcinoma coexisting with an Ovarian Mature Cystic Teratoma. Images of TC
and RM are discussed in the report.
However, ultrasound (transvaginal or abdominal for big masses) has been shown to be the first
indicated test for the diagnosis of adnexal masses, as it not only helps to characterise ovarian
masses, but also to suspect their possible malignancy. Please state why ultrasound was not
performed in this case and the main features you would expect to see. Enclosed you will find an
article that will give you information in case you needed it.
Please attach histological figures if available, whether they are macroscopic or microscopic.
Title: A Rare Case of Malignant Transformation: Squamous Cell Carcinoma Arising on the
Basis of an Ovarian Mature Cystic Teratoma
Version: 2 Date: 05 Apr 2025
Reviewer's report:
The manuscript introduces the concept of malignant transformation of mature cystic teratomas
(MCTs) well, but it would benefit from additional context on the mechanisms behind this
transformation. The authors should include a more detailed discussion on the pathophysiology
of how MCTs undergo malignant conversion, including genetic or molecular factors that could
contribute to such a transformation.
While the case report discusses CT and MRI findings in detail, it could be enhanced by providing
more context on how these imaging results compare to other conditions. For example, how do
the CT/MRI characteristics of this case differ from other ovarian tumors? This could help readers
appreciate the specificity of imaging findings in detecting malignant transformations in MCTs.
surgical intervention is described as unilateral salpingo-oophorectomy, which is appropriate in
this case. However, the manuscript would benefit from a discussion on why this approach was
chosen instead of more radical surgery like hysterectomy or bilateral salpingo-oophorectomy,
especially given the risk of malignancy. Addressing fertility preservation options in this context
could also be important.
I would like to recommend some references for the authors to include in their work:
Bahreiny S S, Ahangarpour A, Harooni E, Amraei M, Aghaei M, Mohammadpour Fard R. Closer
look at circulating nitric oxide levels and their association with polycystic ovary syndrome: A
meta-analytical exploration. IJRM 2024; 22 (12) :943-962
Bahreiny, S. S., Dabbagh, M. R., Ebrahimi, R., Harooni, E. Prevalence of autoimmune
thyroiditis in women with polycystic ovary syndrome: a systematic review and meta-analysis.
The Iranian Journal of Obstetrics, Gynecology and Infertility, 2023; 26(1): 94-106. doi:
10.22038/ijogi.2023.22163
Mohammadpour Fard, R., M. Rashno, and S.S. Bahreiny, Effects of melatonin supplementation
on markers of inflammation and oxidative stress in patients with diabetes: A systematic review
and meta-analysis of randomized controlled trials. Clinical Nutrition ESPEN, 2024. 63: p.
530-539.
Title: A Rare Case of Malignant Transformation: Squamous Cell Carcinoma Arising on the
Basis of an Ovarian Mature Cystic Teratoma
Version: 5 Date: 13 Apr 2025
Reviewer's report:
Thank you for giving me the opportunity to review this interesting study "A Rare Case of
Malignant Transformation: Squamous Cell Carcinoma Arising on the Basis of an Ovarian
Mature Cystic Teratoma".
Almost all reviewer’s comments and recommendations were considered.
Title: Plasminogen Activator Inhibitor 1 is a novel predictor in human serum / follicular fluid
for diminished ovarian reserve
Version: 1 Date: 18 Mar 2024
Reviewer:  Naser Shokrzadeh
Reviewer's report:
1-Authors should be better at talking about the role of PAI-1 in DOR and why choosing this
study in the introduction section.
2-inclusion and exclusion criteria were not shown in the methods and material.
3- in the discussion section, the authors found endometrial thickness in DOR less than  the
control group, but I couldn't find more histology data about that
4-It seems the discussion section should be re-write again and the authors should be better at
indicating the exact findings in their study and compare them to a similar study
Title: Plasminogen Activator Inhibitor 1 is a novel predictor in human serum / follicular fluid
for diminished ovarian reserve
Version: 1 Date: 06 May 2024
Reviewer's report:
This paper examines the expression of Plasminogen activator inhibitor 1 (PAI-1) in the serum
and follicular fluid of patients with Diminished Ovarian Reserve (DOR) as well as in KGN cells
induced by cyclophosphamide (CTX). PAI-1, a type of serine protease inhibitor, is considered
characteristic of aging cells. The authors observed a positive correlation between PAI-1 levels
and the degree of FSH, FSH/LH ratio, and a negative correlation with AMH and AFC. The
correlation analysis and  ROC curve suggested that PAI-1 may serve as a novel molecular marker
and therapeutic target for DOR.  In this regard the study is a welcome addition to the literature.
However, there are some shortcomings that need to be addressed before publication:
The authors should provide a brief description of the IVF cycle process in both the control and
DOR groups. While the number of retrieved oocytes was lower in the DOR group compared
to the control group, the difference was not statistically significant. Moreover, the number of
embryos transferred was higher in the DOR group than in the control group, with insufficient
explanation provided for these results.
The study noted that the concentration of PAI-1 in follicular fluid was significantly higher than in
serum, with the AUC of PAI-1 in serum and follicular fluid being 0.841 and 0.955, respectively.
These findings should be elaborated on in the discussion section.
The authors established a DOR model using KGN cells treated with cyclophosphamide. The
description and results of this experiment were not sufficiently rigorous. It is recommended to
measure the AMH levels of KGN cells after treatment with  GnRHa  for better clarity.
The manuscript should undergo revision by a native English-speaking expert proficient in
scientific English to ensure clarity and accuracy in the language used.
Title: Plasminogen Activator Inhibitor 1 is a novel predictor in human serum / follicular fluid
for diminished ovarian reserve
Version: 3 Date: 21 Jun 2024
Reviewer's report:
The authors have made revisions to the manuscript in response to the comments received.
However, it is still suggested that the manuscript lacks a clear explanation for the
recommendations provided in the revised version.
1.The authors did not sufficiently elaborate on the rationale behind their findings in the
discussion section.
2. While KGN cell treatment with cyclophosphamide could establish a DOR model , the
authors did not offer any additional methods to validate the success of their model construction.
Furthermore, they did not provide evidence of its functionality.