JerMa88/BMC_Womens_Health_Peer_Reviews huggingface dataset:
Title: Diagnostic value of plasma-derived exosomal miR-223 for epithelial ovarian cancer
Version: 0 Date: 25 Sep 2023
Reviewer's report:
The manuscript titled "Diagnostic value of plasma-derived exosomal miR-223 for epithelial
ovarian cancer" authored by Yang and colleagues provides valuable insights into the role of
miR-223 in distinguishing early-stage epithelial ovarian cancers (EOC). However, there are
significant concerns about the manuscript's methodology and presentation.
Major Comments:
In the introduction, the authors did not provide a rationale for selecting miR-223 as a candidate
biomarker. It would be beneficial to explain why this specific microRNA was chosen, either
based on existing literature or prior research by the authors. Furthermore, considering the
collection of 78 EOC samples, it may seem inefficient to focus solely on one miRNA without
additional justification.
In the Materials and Methods section, the authors utilized SYBR Green-based PCR to quantify
the content of miR-223-3p. However, it appears that the primer sequences used did not contain
universal primers. To enhance clarity, the authors should provide a detailed protocol for the
design of primers for both miR-223-3p and the reference gene U6.
In Figure 2B and C, the data for EOC at early-stage vs. late-stage (B) and Non-metastasis
vs. Metastasis (C) appear similar but not identical. It is crucial for the authors to provide an
explanation for the observed differences or similarities between these data sets.
The authors aimed to explore the diagnostic value of plasma exosomal miR-223 for epithelial
ovarian cancer. However, they did not mention the division of samples into training and test
cohorts or the introduction of an external cohort for validation, which is essential for robust
diagnostic research.
Minor Comment:
On page 3, it is noted that "CRC" is not given its full name, and it would be helpful to provide
the full name for clarity.
Title: Diagnostic value of plasma-derived exosomal miR-223 for epithelial ovarian cancer
Version: 0 Date: 16 Oct 2023
Reviewer's report:
The study is dedicated to a very relevant topic, the Introduction section gives enough information
on the study background, the methods are described in detail and are reproducible, the results
are appropriate for the research question, the Discussion presents comprehensive data, and the
references are up to date. Some minor points to be addressed, in my opinion:
- most importantly, as we are talking about the diagnosis, I would like to add visualisation data
here (ultrasound and/or MRI), both in Table 1 and in the statistical analysis - maybe the miRNA
test performance could be improved if combined with US indicators like ADNEX model or
similar? As the presence of ascites, the Doppler score, tumor size have high PPV in OC diagnosis
even without CA125 testing
- the manuscript needs some language improvement, contains typos
- "with a 5-year overall survival is less than 30%" - would be advisable to add a reference here
- "with EOC at the International Federation of Gynecology and Obstetrics (FIGO) stages I-IV
and suitable for surgical treatment" - could you please specify about suitability: operable or
resectable, suitable for R0 or for biopsy, specific criteria used
- "benign patients who received anti-tumor treatment before surgery" - this is probably a writing
error?
- Table 1 - CA125 values are presented as a mean - would like to clarify if that is correct as
CA125 frequently demonstrates a wide range of values and an abnormal distribution
Title: Diagnostic value of plasma-derived exosomal miR-223 for epithelial ovarian cancer
Version: 3 Date: 24 Nov 2023
Reviewer's report:
The major comments are not well addressed. I highlights three critical areas of concern:
1.Rationale for miR-223 selection: The authors didn't explicitly justify why miR-223 was chosen
as a biomarker over other microRNAs, despite multiple references in the introduction supporting
microRNA as biomarkers.
2.Insufficient detail on miR-223-3p primer design: The revised content focused on language
rather than explaining the primer design for miR-223-3p. Providing the sequence and a visual
explanation might enhance clarity in this aspect.
3.Lack of robust training and validation cohorts: The study's credibility to conclude that plasma-
derived exosomal miR-223 is a diagnostic tool for epithelial ovarian cancer is questioned due
to the absence of adequate training and validation cohorts.
Title: Healthcare providers’ experience of identifying and caring for women subjected to sex
trafficking: a qualitative study
Version: 0 Date: 12 Dec 2023
Reviewer's report:
My critical point about the article:
Title: it is brief and attractive, but instead of putting interview study, I would put qualitative
study.
Summary: Design in the method.
Introduction: Within the introduction of the article there are many sentences without quotations.
Some sentences are longer than three lines. I recommend that you do not make such long
sentences and that you break them into several to favour readability.  In addition, the article does
not justify the need for the study based on the literature. Conclusion The introduction needs to
be improved.
Methodology:
Does not include the design (phenomenological, ethnographic, grounded theory...) and also does
not demonstrate an understanding of the proposed methodology. I suggest that you indicate a
design (qualitative descriptive) and ground it theoretically.
The setting should go along with the participants, not with the design of the study. (It can go
with the design -Design and setting-. You can put it as a suggestion)
Does not reflect exclusion criteria. Selection (inclusion and exclusion)
Participants: Does not include socio-demographic data of participants, or how they were
recruited. It is also a small sample.
Data collection: This does not include dates and strategies. It also does not say who conducts
the interview.
The duration of the interviews can be better expressed as it ranges from 40 to 70 minutes. Please
indicate the average duration.
Data analysis. Wouldn't say content analysis if not Thematic analysis.
Do not include Rigour: cite a reference author for rigour, and explain how you ensured rigour.
Results:
In the result, you do not conclude. In this paragraph, before defining the themes and sub-themes,
the characteristics of the participants are discussed. Number of women or men who participated.
The average age of the participants.
In the table of categories and subcategories, it would be interesting to have a unity of meaning.
The names of some themes could be more explanatory of their content. For example,
Limited time... for what). I suggest you try to put more explanatory names to themes and
sub-themes (I suggest you watch this video about themes: https://youtu.be/4voVhTiVydc?
feature=shared&t=760).
Discussion:
There is some sentence quoted in Vancouver and some in APA.
Title: Healthcare providers’ experience of identifying and caring for women subjected to sex
trafficking: a qualitative study
Version: 1 Date: 09 Jan 2024
Reviewer's report:
Comments to the Editor:
Firstly, I would like to thank the editor and authors again for the opportunity to review this article
on such a disturbing current issue. It also requires evidence and awareness.
My constructive comments on the article are as follows
Title: I have no comment.
Abstract: I have no comment
Introduction:
The main comment is that you should check the introduction and quote every sentence. I
recommend that there should be no sentence without a quotation. I recommend that you do not
make sentences too long and that you break them up into several sentences for readability. I also
recommend that the introduction should be no longer than three pages.
Methodology:
I recommend that there is no paragraph between the methodology and the design. You can
include it in the design or remove it. Can you write the study design without the setting?
I suggest that study participants and setting be one bullet point, data collection another bullet
point.
I suggest that you include the table with the socio-demographic data of your study participants.
Data collection: There are no dates. Nor does it say who is conducting the interview.
In conclusion, I recommend that you structure the methodology well, provide the table with the
socio-demographic data, and improve the methodology.
Results: I have no comments.
Discussion
I am aware that there is some information that is the result of your study, but there is other
information that is not, therefore I recommend you to revise the discussion and cite the
information extracted from other studies. Finally, I suggest that you improve the discussion.
Restriction: I have no comment
Conclusion: I have no comment
Title: Healthcare providers’ experience of identifying and caring for women subjected to sex
trafficking: a qualitative study
Version: 1 Date: 22 Jan 2024
Reviewer:  Mariana Calderón-Jaramillo
Reviewer's report:
Thank you so much for this new opportunity to review this manuscript. I consider  that all
my comments and suggestions are included in the new version. I think this article presents
novel evidence about a topic  characterized by scarce evidence and limitations regarding data
collection.
Title: Healthcare providers’ experience of identifying and caring for women subjected to sex
trafficking: a qualitative study
Version: 3 Date: 11 Feb 2024
Reviewer's report:
I am grateful for the opportunity to review this manuscript. I am of the opinion that all of my
constructive remarks and suggestions have been incorporated into the current version. I am of
the opinion that this article presents novel evidence in an area that is characterized by a dearth
of evidence and limitations in data collection.
Title: Prevalence and Determinants of Gestational Diabetes Mellitus among Pregnant Women
in India: An Analysis of National Family Health Survey Data
Version: 2 Date: 16 Oct 2023
Reviewer:  Sheikh Mohd Saleem
Reviewer's report:
Review Report on "Prevalence and Determinants of Gestational Diabetes Mellitus among
Pregnant Women in India: An Analysis of National Family Health Survey Data"
The paper presents a comprehensive analysis of gestational diabetes mellitus (GDM) prevalence
among pregnant women in India using data from the National Family Health Survey
(NFHS) conducted in 2015-16 and 2019-21. By examining various demographic factors and
determinants, the study sheds light on the complexities of GDM and its associated risk factors.
While the research offers valuable insights, there are notable areas for improvement that could
enhance the overall impact and credibility of the study.
Areas of Improvement:
While the use of self-reported data from NFHS is common, there is a need to acknowledge its
limitations. Considering potential reporting biases, exploring methods to enhance data accuracy,
such as cross-referencing with medical records or incorporating validation techniques, could
strengthen the study's credibility.
Differentiating between types 1, type 2, and gestational diabetes would add granularity to the
findings. Understanding the specific impact of GDM, distinct from other diabetes types, is
crucial for targeted intervention strategies.
The paper lacks an in-depth exploration of cultural and social factors influencing GDM
prevalence. Integrating qualitative research methods, such as interviews or focus group
discussions, could provide valuable context and depth to the study’s findings, ensuring a more
holistic understanding. This could be mentioned in limitation if out of the scope of the study or
suggest this for future studies.
While the study identifies associations, there is a need to bridge the gap between research
and policy implications. Discussing potential policy recommendations based on the findings
would enhance the practical relevance of the research, guiding policymakers and healthcare
practitioners in effective decision-making.
The research paper significantly contributes to the understanding of GDM among pregnant
women in India. Addressing the highlighted areas of improvement would not only enhance the
study's credibility but also broaden its impact on maternal healthcare policies. By incorporating
these suggestions, future iterations of this research could offer even more nuanced insights,
driving positive changes in maternal and child health initiatives in India.
Title: Prevalence and Determinants of Gestational Diabetes Mellitus among Pregnant Women
in India: An Analysis of National Family Health Survey Data
Version: 2 Date: 25 Oct 2023
Reviewer's report:
1. The novelty and value addition of the findings may be made clear.  At its present form, the
study identifies various correlates of GDM.
2. The public health implications and clinical relevance of these findings are to be elaborated
in the manuscript.
3. the change in the prevalence of GDM could be for many factors Individual to health system
level.  Please discuss and describe how the analysis has taken into account those influencing
factors
Title: Prevalence and Determinants of Gestational Diabetes Mellitus among Pregnant Women
in India: An Analysis of National Family Health Survey Data
Version: 2 Date: 19 Nov 2023
Reviewer:  Swayam Pragyan Parida
Reviewer's report:
I must congratulate the authors.
Overall a nice manuscript.
Section  Page number, Line number Comments
Title  NFHS study - should be mentioned
Abstract, results P 2, L 30 Prevalence overall should be there as its in objective
Background  Reduce
Mention: 1. What’s known, 2 what’s not known, 3. rationale of present study and 4. objectives
Methods, data source L 135-137 Expand the terms first, afterwards abbreviations can be used
Results  L 172 - 173 Can be put before Table 1
Table 3  1. If NFHS 4 Vs 5 data shown then the figures from 3 – 7 can be removed
2. N needed
3. Age in years to be mentioned
4. In caste: Others can be broken down to General etc
Table 2, Figure 2 State wise difference in prevalence of GDM Fig 2 may be removed. Additional
points can be incorporated in Table 2
Line 241 Prevalence can be presented in decreasing order
Discussion  L 328 - 332 Categorisation of states in to Least developed, developing , most
developed
Explain on what basis.  Some other terms like EAG can be mentioned
Conclusion  L 392 - 405 Reduce.
Mention only relevant points.
Conclusion   Mention limitations of existing program for GDM and what can be done to improve
the existing program
Table 4 P 21 1. Age group:  mention in years
2. In smoking section: what is the meaning of
…cons
Ethics approval  Is required even for secondary data analysis
Title: Prevalence and Determinants of Gestational Diabetes Mellitus among Pregnant Women
in India: An Analysis of National Family Health Survey Data
Version: 3 Date: 17 Jan 2024
Reviewer:  Swayam Pragyan Parida
Reviewer's report:
Congratulations to the authors for the research.
I have one suggestion.
In conclusion, in the  below mentioned line, please refrain from using the words  "transfer  the
disease",
[The mother suffering from diabetes can transfer the disease to her offspring,].
Non communicable diseases are not transferrable. however, the chances of DM in offspring  at
a later age, is higher if a mother develops GDM.
Title: Prevalence and factors associated with second hand smoke exposure among a sample of
pregnant women in Cairo, Egypt
Version: 1 Date: 06 Jul 2023
Reviewer's report:
1. data were collected very remotly  and mostly not reflecting the present situation
2. It was better to exclude smokers from the study and divide them into only SHS exposed and
non exposed.
3. was the used questionnair or surve tool  in Arabic or English
4. what were the validity and reliability of the used survey tool
5. there was no referance of the adapted tool
6. exposure to SHS in other places rather than home was not mentoned like work or public places
7. how can you define sometimes, often and so on....it is very subjective
8. what is the value of measuring CO level  and how to interpet this among smokers...again it
was better to exclude smokers as it was not the aim of study to measure tobacco exposure...it
was only SHS
9. what is the difference between hookah and shisha ....if the same please refer to it by either
names and if different explain the difference
10. you mentioned the collection of sociodemographic data in the start of the paragraph
then mentoned SHS exposure data then went back to mention residency, age and educational
level......rearrange
11. in the results...88 participants were residing in rural area.....strange provided the study was
conducted in Cairo
12. based on the current statistical appoach, the study did not focus in associated factors ....it
shoud contain a table describing only ladies with SHS exposure aganist the risk factors (yes,no)
in order to get relative risk.
Title: Prevalence and factors associated with second hand smoke exposure among a sample of
pregnant women in Cairo, Egypt
Version: 1 Date: 19 Sep 2023
Reviewer's report:
The manuscript is very well written; it is clear, precise, and interesting to read.  A good amount
of work was involved in the study, and as far as I can determine, the work is solid.
The only thing is that the small sample size used for this study really limited its generalizability
to other Egyptian women. Considering the long fieldwork duration, and how it should not be
difficult to get an adequate number of pregnant women attending hospitals in Egypt.
Title: For the above mention on generalizability, I am suggesting changing the title to:
Prevalence and factors associated with secondhand smoke exposure among a sample of pregnant
women in Cairo, Egypt.
Abstract
Line 43, better correct attitude, not attitudes as the word uncountable
Introduction Line 127 “Cairo Metro Area”, better to use the word metropolitan in this context
than the abbreviated one.
Methodology: the section is very well written and all the variables and measures used were
mentioned in detail.
Line 159:  first mentioned hookah, here indicates that is the water pipe smoking that ii well
known as Shisha in Egypt
Results:
The section is well written, and all the statistical analyses are sound and correctly done.
Table 1: It is advisable to separate Table one into two tables, one for sociodemographics and
the other for secondhand smoke. They are two different entities, and they’re not related enough
to be included in the same context.
Line 268: “ was harmful to their or their’  correct
Discussion section:
The discussion is very detailed, and it gives a comprehensive understanding of your study as
a whole. However, it only needs to be supported more by reference citations from within the
Egyptian context. E.g. Line 355   “”Current policies allow for non-smoking areas within public
places”” , better to refer to the current policies in Egypt than to the one's with international
context. Try to enrich it with a couple more references referring to unique situation of Egypt
in this regard.
Line 335 : ”Pregnancy can be an important motivator for behavior change,” A reference to
support this sentence is needed.
Title: Association between intimate partner violence and pregnancy intention: evidence from
the Peruvian Demographic and Health Survey
Version: 0 Date: 09 Dec 2023
Reviewer:  Beatriz Paulina Ayala Quintanilla
Reviewer's report:
Please see below my comments:
1. In Table 1, there are 884 women without a partner so that I would like to know how the authors
determined Partner´s education level for those women. I have the same concern for this item in
Table 2 (there are 187 women without partner).
2. I think that the authors should indicate from which pregnancy was data about number or
Prenatal checkups and contraceptive use.
3. I would like to know why the authors did not include the variable “number of ANC visits”
in the Model of Table 4.
4. The authors should consider include the following publications:
https://www.sciencedirect.com/science/article/pii/S1871519215000050
https://www.sciencedirect.com/science/article/pii/S0020729212003980
Title: Association between intimate partner violence and pregnancy intention: evidence from
the Peruvian Demographic and Health Survey
Version: 0 Date: 27 Dec 2023
Reviewer:  Shusmita Khan
Reviewer's report:
- Overall English copyediting is being suggested.
- In abstract section, please operationalize “intimate partner violence”.
- If variable available, then please adjust by the following variables. Because we have seen these
variables to be associated in other papers
o Living condition
# Joint family
# Nuclear family
o Duration of marriage/partnership
o Age at marriage/partnership
o Spousal/partners age gap
o Duration of marriage/ partnership and parity
Title: Analysis of influencing factors of HPV vaccination willingness of female sex workers in
urban entertainment venues based on the IMB model in Guangxi, China
Version: 2 Date: 15 Jan 2024
Reviewer:  Yanqin Yu
Reviewer's report:
The study by HE Zhiyan et al. was Analysis of Influencing Factors of HPV Vaccination
Willingness of Female Sex Workers in Urban Entertainment Venues Based on IMB Model
in Guangxi, China. Their findings showed that the higher the level of awareness of HPV and
HPV vaccine-related information, the stronger the motivation for HPV and HPV vaccination,
and the higher the behavioral skills score, the higher the willingness of female sex workers in
entertainment venues to receive HPV vaccination. This is an interesting paper as it evaluates an
HPV vaccination among women living urban entertainment venues in Guangxi, where cervical
cancer is a problem due to poor health systems and job natures. However, some important issues
need to be addressed to make the paper strong.
Major Issues:
1. Pay attention to modifying English expressions, it can help me to understand the meanings that
reflect your expression. Such as“ To investigate the willingness of female sex workers in urban
entertainment venues in Guangxi, China to vaccinate against HPV and its influencing factors”.
2. In your article, you may need add the sample size for this investigation and the number of
ethical proofs.
3. Inclusion criteria and exclusion criteria may be removed in Respondents of the Study, please
finished it.
4. In your article, you must promise to consistent with the expression in before and after,
including the capitalization of statistical symbols such as P values, which should be capitalized
and italicized. Please finished it.
5. Please add your limits and strength.
6. In your article, you must give standard for variables entry and exclusion in Logistic regression
model.
Title: Analysis of influencing factors of HPV vaccination willingness of female sex workers in
urban entertainment venues based on the IMB model in Guangxi, China
Version: 2 Date: 18 Jan 2024
Reviewer's report:
I read the Manuscript titled “Analysis of Influencing Factors of HPV Vaccination Willingness of
Female Sex Workers in Urban Entertainment Venues Based on IMB Model in Guangxi, China”
which falls within the aim of the Journal.
Although the manuscript can be considered already of good quality, I would suggest following
recommendations:
- I suggest a round of language revision, in order to correct few typos and improve readability.
- The persistence of HPV infections is one of the most significant predictors for the risk of
recurrence of cervical diseases. Considering topic of this study, I suggest that authors to add
references about recent evidence of these topics. I would be glad if the authors discuss this
important point, referring to PMID: 37401466.
- Authors should consider recent evidence about HPV-related lower genital tract lesions, also
after treatment, considering the potential role of ant-HPV vaccination. I would be glad if the
authors discuss this important point, referring to PMID: 37978580
Because of these reasons, the article should be revised and completed. Considering all these
points, I think it could be of interest to the readers and, in my opinion, it deserves the priority
to be published after minor revisions.