Reviewer’s report
Title: 
The value of melatonin supplementation in postmenopausal women with
Helicobacter pylori-associated dyspepsia
Version: 
1 
Date: 
21 Aug 2020
Reviewer's report:
It is a well written, clear article of an interesting theme. 
I have just some few statements:
Background: 
- what is the incidence of gastrointestinal disorders in postmenopausal women?
Based upon this, is the group of women in whom it was done melatonin
suplementation able to allow those conclusions?
Exclusion criteria:
- I wonder if it would not be interesting to have a group of symptomatic patients
with hormonal replacement to compare to placebo and melatonin suplementation
groups. Would it be different as melatonin versus placebo?
Laboratory tests:
- It is not clear for me why seven days prior the evaluation a liquid diet was
done.
- Would the therapeutic procedure done with antibiotics affect melatonin levels?
- I would have measured the melatonin level after 6 months to evaluate if oral
suplementation was successfull
Results:
- Based upon table 2 we see difference only after 3 months, so the
suplementation shoud be done for at least 6 months to achieve clinical results? (if
so it could be mentioned in conclusion)
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