Reviewer’ s report
Title: Long-term Multidisciplinary Treatment Including Proton Therapy for a Recurrent Low-
Grade Endometrial Stromal Sarcoma and Pathologically Prominent Epithelial Differentiation: AnAutopsy Case Report
Version: 0Date: 23 May 2020
Reviewer: Jesus Salvador Jiménez López
Reviewer's report:
Please include all comments for the authors in this box rather than uploading your report as an
attachment. Please only upload as attachments annotated versions of manuscripts, graphs,supporting materials or other aspects of your report which cannot be included in a text format.
Please overwrite this text when adding your comments to the authors.
Title: Long-term Multidisciplinary Treatment Including Proton Therapy for a Recurrent Low-Grade Endometrial Stromal Sarcoma and Pathologically Prominent EpithelialDifferentiation: An Autopsy Case Report1.a. ORIGINALITY:The study presented by the authors details the multidisciplinary action in decision-making in theface of a particularly complex case in its evolution during the 25-year follow-up.1 B. STATEMENT OF OBJECTIVES:report presents her progress and pathological change since the previous report.1.c.-METHODOLOGY:The structure is adequate, detailing the clinical evolution as well as the sequence of
multidisciplinary treatments such as pathological differentiation of the tumor specimen and its
changes over time.1.d. CLARITY OF RESULTS:The results are well presented and easy to interpret. Clear, precise. Adequate sequence ofparagraphs. All tables and figures are listed and have an explanatory footer. Cite all bibliographicreferences.Tables are self explanatory. Simple and easy to understand.
1.e. TITLE:
The title corresponds to the development of the work, and the reading of the work responds to theexpectations raised by the title.1.f. DISCUSSIONIt highlights the relevant aspects of the clinical case that could be useful in clinical practice.The strengths of this study lie in the detailed and detailed analysis of the clinical case. Establishingand interpreting tumor and clinical case evolution based on the findings.We agree with the authors that cases as complex as the one they present highlight the performanceof multidisciplinary medical-surgical units. And it opens the door to novel treatments such as theuse of protons as a therapeutic tool.
2.a. PRACTICAL APPLICATION AND INTEREST
It provides clinically relevant information in similar cases and of very difficult handling. It allows
establishing a tree in decision-making to order medical-surgical treatment in patients with tumorrecurrence symptoms.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
Not relevant to this manuscriptQuality of written English
Please indicate the quality of language in the manuscript:
AcceptableDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?
6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
'I declare that I have no competing interests'
Reviewer Publication Consent. I agree for my report to be made available under an Open Access
Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manu-script is accepted for publication. Any comments that I do not wish to be included in the publishedreport have been included as confidential comments to the editor, which will not be published.Ifyou are not happy for us to publish this report, please contact the editorial office before completingthe review.If you wish, you can include your name in your published report. Please note you mustdecide whether to include your name at the start of the process and confirm this decision wheneverprompted. If you change your decision later, we will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please publish my name with my report.