JerMa88/BMC_Womens_Health_Peer_Reviews huggingface dataset:
Title: Home and outpatient electrostimulation in the treatment of urinary incontinence in
women: A systematic review
Version: 4 Date: 02 Dec 2024
Reviewer's report:
While the field is  evolving, it's important to consider the potential limitations of conducting a
systematic review at this stage. Given the emerging nature of research in this area, there may
be a lack of robust, high-quality studies to draw definitive conclusions. As such, any systematic
review conducted now may be subject to significant limitations and may require frequent updates
to incorporate new evidence.
It would be beneficial to briefly introduce the specific techniques used for treating UI, such as
sacral nerve stimulation and functional electrical stimulation.
You could elaborate on the potential benefits of home-based ES beyond convenience and
flexibility. For example, discuss how it could reduce healthcare costs and improve patient
autonomy.
Clearly state the specific research gap that your study aims to fill. For instance, you could
highlight the lack of rigorous studies comparing the efficacy and cost-effectiveness of home-
based and outpatient ES.
While the databases searched are appropriate, providing more details about the specific search
terms and Boolean operators used would enhance the transparency of the search process.
Consider adding a table summarizing the search terms used in each database.
Briefly describe any filters or limits applied to the search.
While the heterogeneity of the included studies is acknowledged, a more detailed discussion of
the specific sources of heterogeneity (e.g., differences in ES parameters, patient populations,
and outcome measures) could be helpful.
The summary could delve deeper into the patient-reported outcomes, such as quality of life, and
discuss the potential impact of home-based ES on these outcomes.
Although the need for economic evaluations is mentioned, a more in-depth discussion of the
potential cost-effectiveness of home-based ES could be beneficial.
While further research is needed, specific recommendations for future studies could be provided.
For example, future studies could focus on optimizing ES parameters, developing standardized
protocols, and conducting larger, well-powered trials.
Discuss the implications of the findings for clinical practice, particularly in terms of patient
selection and treatment recommendations.
Explore patient preferences for home-based versus outpatient ES and the factors that influence
these preferences.
Title: Relationship Between Psychological empowerment, Physical Activity Enjoyment, and
Response to a HIIT Program in Physically Inactive Young Women: A Prospective Multicentre
Study
Version: 3 Date: 09 Jan 2025
Reviewer's report:
Thank you for your commitment to manuscript enhancement.
Your revision addressed all issues within your capability in a very impressive manner.
I have no further specific concerns to raise at this time.
Title: Characterization of tumor prognosis and sensitive chemotherapy drugs based on
cuproptosis-related gene signature in ovarian cancer
Version: 1 Date: 09 Jul 2024
Reviewer:  Dubravko Habek
Reviewer's report:
Original contribution to oncology medicine, especially ovarian cancer. the work has all the
elements of originality, methodology and numerous results, as well as discussion with fresh
literary data focused on the topic.
However, the results, which are graphically presented in 9 pictures with 5-6 tables or graphs
each, should be halved, because almost half of the article is exclusively pictorial.
Title: Characterization of tumor prognosis and sensitive chemotherapy drugs based on
cuproptosis-related gene signature in ovarian cancer
Version: 1 Date: 11 Jul 2024
Reviewer:  Burak Sezgin
Reviewer's report:
Authors said that cuproptosis  a new type of cell death that  play crucial role in the therapy and
prognosis of ovarian cancer. I think this an interesting and  well written manuscript. It contributes
to the the role of cuproptosis in ovarian cancer .
Title: Characterization of tumor prognosis and sensitive chemotherapy drugs based on
cuproptosis-related gene signature in ovarian cancer
Version: 1 Date: 12 Jul 2024
Reviewer's report:
I read with great interest the Manuscript titled " Characterization of tumor prognosis and
sensitive chemotherapy drugs based on cuproptosis-related gene signature in ovarian cancer”,
topic interesting enough to attract readers' attention.
Although the manuscript can be considered already of good quality, I would suggest following
recommendations:
- I suggest a round of language revision, in order to correct few typos and improve readability.
- Considering the clinical case and the topic analyzed, the authors could extend and improve the
discussion by evaluating and citing current evidence about possible target therapeutic strategies
for patients with ovarian cancer.  I would be glad if the authors discuss this important point,
referring to PMID: 37314974 and 38768941.
Because of these reasons, the article should be revised and completed. Considering all these
points, I think it could be of interest to the readers and, in my opinion, it deserves the priority
to be published after minor revisions.
Title: Characterization of tumor prognosis and sensitive chemotherapy drugs based on
cuproptosis-related gene signature in ovarian cancer
Version: 1 Date: 14 Jul 2024
Reviewer:  Phuc Nhon Nguyen
Reviewer's report:
Dear authors,
The study sounds interesting.  The findings provide novel insights in ovarian cancer treatment.
However, the study population with study group and control group remains unclear. Inclusion
and exclusion criteria should be provided.
R-package was missed for software information (country, year of product, version).
Best regards,
Title: Characterization of tumor prognosis and sensitive chemotherapy drugs based on
cuproptosis-related gene signature in ovarian cancer
Version: 1 Date: 14 Jul 2024
Reviewer:  Ahmed Taher Masoud
Reviewer's report:
The authors present good work and solid survival analysis for patients with ovarian cancer.
1.  The whole paper is full of grammatical and language issues. Please consider a native English
language editing service.
2. Abstract: Needs more details especially the methods section
3. Introduction: Please add details on currently established genes that correlate with ovarian
cancer and predict survival.
4. Methods: Add more details on the analysis method used, the analysis seems a little vague
and not reproducible.  How did the authors assess the presence of confounding ? How did they
adjust for it?
5. Results:  Very good presentation of the results.
6. Discussion: several language flaws and grammatical errors.
Title: Characterization of tumor prognosis and sensitive chemotherapy drugs based on
cuproptosis-related gene signature in ovarian cancer
Version: 1 Date: 14 Jul 2024
Reviewer's report:
Thank you very much for the opportunity to review the manuscript.
The manuscript "Characterization of Tumor Prognosis and Sensitive Chemotherapy Drugs
Based on Cuproptosis-Related Gene Signature in Ovarian Cancer" is of great interest and
presents a novel study on the prognostic value of cuproptosis-related genes and their association
with chemotherapy sensitivity in ovarian cancer. The abstract provides a succinct summary,
covering the background, methods, results, and conclusions and it effectively highlights key
findings. The introduction offers a comprehensive overview of current understanding of
cell death processes in ovarian cancer, specifically focusing on necroptosis, pyroptosis, and
ferroptosis. The methods section is thorough and well-structured, detailing the extraction of
gene expression profiles from GSE140082, construction of risk models, and development of
the nomogram. The results are clearly presented, highlighting the identification of MTF1 and
LIAS as protective factors and the significant association of the high-risk group with poor
survival. The discussion effectively interprets the findings, emphasizing the prognostic value
of cuproptosis-related genes and potential for developing targeted therapies. The integration of
the risk score with clinical characteristics is a notable strength. The conclusion summarizes the
study's contributions, emphasizing the prognostic value of cuproptosis-related genes and their
potential role in developing therapeutic strategies. The figures and additional files, including
images of various figures, appear comprehensive. Overall, this manuscript is well written and in
the scope of the journal and it presents a novel and well-executed study on the prognostic value
of cuproptosis-related genes in ovarian cancer. In order to improve the quality and transparency
of the manuscript the following points should be addressed.
1. Introduction would benefit from more detailed information on previous research related to
cuproptosis in other cancers in order to strengthen the study's rationale.
2. Please, try to provide more detailed information on statistical methods and software used in
the methods section.
3. I would suggest comparing findings with existing literature and discussing potential
limitations in the discussion.
4. Try to ensure all figures are clearly labeled and described in the manuscript.
Title: Characterization of tumor prognosis and sensitive chemotherapy drugs based on
cuproptosis-related gene signature in ovarian cancer
Version: 1 Date: 14 Jul 2024
Reviewer's report:
Dear Editor,
Thank you for allowing me to review this study. I have several concerns and questions regarding
the manuscript:
Abstract:
Type of Study:
What was the type of study conducted? Was it observational, experimental, retrospective, or
prospective?
Population of Study:
Who were the participants or population of the study? Please specify the inclusion criteria for
the patients.
GSE140082:
What is GSE140082? Please provide a brief explanation of this dataset.
Line 16: "Survival analysis was used to screen prognostic genes for the construction of risk
models."
Could you clarify this sentence? What specific survival analysis methods were used to identify
prognostic genes?
"Ultimately, the clinical characteristics, tumor progression, and metabolism-related pathways,
immune landscape, and drug sensitivity in two risk groups of patients with ovarian cancer were
analyzed."
Which two risk groups of patients are being referred to here? How were these groups defined?
Methods:
The methods section in the abstract is unclear. Please clarify the following points:
Screening Prognostic Genes:
What specific statistical methods were used for survival analysis to screen prognostic genes?
Risk Models:
How were the risk models constructed? What criteria were used to classify patients into high-
risk and low-risk groups?
Clinical and Biological Analysis:
How were the clinical characteristics, tumor progression, metabolism-related pathways, immune
landscape, and drug sensitivity analyzed between the two risk groups?
Results:
"MTF1 and LIAS were protective factors":
What are MTF1 and LIAS? Please provide a brief description of these genes and their relevance
as protective factors in ovarian cancer.
"Integration of the risk score with clinical characteristics in the nomogram showed high
specificity and sensitivity of survival prediction":
Which risk score was integrated with clinical characteristics? How was this integration
performed?
"A higher fraction of M2 macrophages, follicular helper T cell, and resting mast cells were
observed in the high-risk group":
What defines the high-risk group in this study? How was this group identified?
Additional Concerns:
Line 71: "Normal sample of what?":
What is the normal sample referring to? Is it normal ovarian tissue, adjacent non-cancerous
tissue, or something else?
"limma” package:
The "limma" package belongs to which software? Please specify that it is part of the R software
environment for statistical computing.
"Significance analyses were performed using unpaired Wilcoxon Rank Sum and signed Rank
tests":
Why was the unpaired Wilcoxon Rank Sum test used? What was the rationale behind choosing
this test for the analyses performed?
The method section is not clear, and further details are needed to understand the study design,
analytical methods, and findings fully.
Title: Characterization of tumor prognosis and sensitive chemotherapy drugs based on
cuproptosis-related gene signature in ovarian cancer
Version: 2 Date: 01 Aug 2024
Reviewer:  Phuc Nhon Nguyen
Reviewer's report:
Dear authors,
Thank you for your revision.
This bioinformatic study contributes importantly to the literature gap concerning cuproptosis-
related genes in ovarian cancer as well as prognostic risk model for ovarian cancer patients.
The paper is more clarified in this current form.
I have no more comments.
Congratulation on your great work.
Yours sincerely,
Phuc Nhon NGUYEN MD
Tu Du Hospital, Ho Chi Minh City, Vietnam
Title: Knowledge of the ovulatory cycle and its determinants among adolescent females in
Ghana
Version: 0 Date: 02 Sep 2024
Reviewer:  Frank Baiden
Reviewer's report:
This is a very well-written paper. The introduction set a clear stage for the rationale of the study.
The methods section was written in such detail that it will be possible to replicate it  without
needing to refer to the author. The results were clearly presented. The information contained in
figure 1 can well be carried in text and the figure deleted. Tables 1 and 2 can also be combined
to have one table that has univariate, bivariate and multivariate analyses. This makes for clearer
appreciation of the results at a go. The discussions highlighted the major findings and related
them well with findings from similar studies in the sub-region. The conclusions can be made
more concise and focused. There is need for consistency in the referencing style. I have some
other comments (largely minor) for consideration. They appear by way of tracked changes in
the manuscript.
Title: Knowledge of the ovulatory cycle and its determinants among adolescent females in
Ghana
Version: 1 Date: 18 Oct 2024
Reviewer's report:
Comment for Author:
Dear Editor,
Thank you once again for inviting me to review the revised document. While most of my
previous comments have been addressed, I still have a few minor suggestions:
1. Line 22 of the abstract: It mentions the prevalence of knowledge. Please change this to "level
of knowledge," as the term "prevalence" typically refers to disease or clinical outcomes.
2. On the same line, you present the level of knowledge as 26.5% and the confidence interval (CI)
as a proportion (CI = 0.248 – 0.282). Please adjust the CI format to percentages for consistency
with the level of knowledge.
3. Inconsistency in decimal places: You reported the odds ratio (OR) with two decimal places
(AOR = 2.85) but used three decimal places for the confidence interval (CI = 1.475 – 5.512).
Please standardize this for consistency.
4. In my previous review, I suggested including a diagram for the data extraction method, but this
has not been addressed. I still recommend adding this visual representation to enhance clarity.
5. Regarding my question about data analysis: I asked whether you checked for any correlation
or clustering effects. Your response was not fully accurate, as the presence of clustering effects
should be checked using the intraclass correlation coefficient (ICC). If you checked for ICC,
please provide its value. If the ICC is greater than zero, multilevel analysis would be appropriate.
The choice between logistic and multilevel analysis depends on the ICC value, so this needs
to be clarified.
Thank you again for your efforts, and I look forward to reviewing the updated manuscript.
Title: Abortion and contraception within prison health care: A qualitative study
Version: 3 Date: 11 Dec 2024
Reviewer:  Laura E. T. Swan
Reviewer's report:
Thank you for the opportunity to re-review this manuscript. I found the paper to be much
improved and nearly ready for publication. I have provided a few minor points for revision.
1. Your framework section still doesn’t read quite right. The edited sentence “The concepts of
a reproductive justice framework includes…” is vague and confusing. What is a concept of a
framework?
2. What is your evidence of data saturation? Moreover, I would caution against using the term
saturation, which is specific to grounded theory, in a study that did not use this approach. I
suggest using the similar but more broadly applicable concept of information power. Regardless,
please add details about how you determined that saturation or information power was reached.
3. I really appreciate the added details about the analytic process. However, full attention to
the reflexivity in your reflexive thematic analysis is still missing. You have stated some details
about the identities of your research team, which is an important first step. Now, you need to
reflect on how those identities may have added to or taken away from your study. Please add
these details into your manuscript.
4. Please edit table 1 to reflect your revisions. “Contraceptive denial or coercion” was changed
to “contraceptive coercion” in the paper but not in the table.
Title: Changing Trends in the Global Burden of Polycystic Ovarian Syndrome-Related
Infertility over the Past 30 Years: Retrospective Data Analysis of the Global Burden of Disease
Study 2019
Version: 1 Date: 26 Sep 2024
Reviewer:  Jianyang Feng
Reviewer's report:
Review Report
General Comments: Huo M, et al. Investigated the temporal trends of Polycystic Ovarian
Syndrome-Related Infertility (PCOS) from 1990 to 2019 by integrated analysis of Global
Burden of Disease Study 2019. They found that the prevalence and burden of PCOS-related
infertility varied across the world. And the manuscript was well written and organized. The
figures and tables are also well readable.
Fertility is severely hampered by PCOS. And the main clinical manifestation of PCOS is the
disease-driven infertility in women at childbearing age. To investigate the temporal treads of
PCOS-related infertility facilitates making policy to reduce the burden of disease.
Comment #1: As authors illustrated in the manuscript that ASPRs and ASYRs were positively
correlated with SDI (R=0.419 and 0.433, respectively, all P < 0.0001), and the AAPCs in
ASPRs and ASYRs were negatively correlated with SDI (R= –0.570 and –0.571, respectively,
all P < 0.0001). The inequality of the distribution of PCOS-related infertility exists. The health
care system, age, and education across the world differ. It will be better to measure the health
inequality analysis across different regions to interpret the findings.
Title: Changing Trends in the Global Burden of Polycystic Ovarian Syndrome-Related
Infertility over the Past 30 Years: Retrospective Data Analysis of the Global Burden of Disease
Study 2019
Version: 1 Date: 17 Oct 2024
Reviewer:  Yigit Cakiroglu
Reviewer's report:
General comments:
This retrosepctive data analysis has been processed in accordance with the author guidelines of
the journal. The writing style is concise and clear. The manuscript proposes detailed information
about the global burden of PCOS in a large number of data analysis from a wide perspective.
Abstract:
The abstract accurately describes the short-summarized content of the article.
Key words are adequate in quality and number.
Introduction:
The rationale of infertility, effect of age on infertility, PCOS, PCOS-related infertility have been
well defined in the introduction section. Aim has been defined.
Materials and Methods
The materials and method section contains briefly and comprehensively the type of the article
with adequate number of cases, search strategy, data source, variables, and statistical analysis
employed.
Results
The result section contains important and significant findings and observations in regards of the
included studies. Age-specific burden, diseased burden trends have been analysed in detail.
Discussion
The discussion section states the importance and significance of the findings in a very detailed
way. Conclusion part reflects the main idea of the MS.
References:
The references section contains appropriate and reasonable number of references
Figures:
The figures are so demonstrative and clear
Tables:
The tables are well designed.
Title: Changing Trends in the Global Burden of Polycystic Ovarian Syndrome-Related
Infertility over the Past 30 Years: Retrospective Data Analysis of the Global Burden of Disease
Study 2019
Version: 2 Date: 30 Oct 2024
Reviewer:  Yigit Cakiroglu
Reviewer's report:
I would like to thank the authors for the revision of the MS according to the suggested
recommendations.
Title: Changing Trends in the Global Burden of Polycystic Ovarian Syndrome-Related
Infertility over the Past 30 Years: Retrospective Data Analysis of the Global Burden of Disease
Study 2019
Version: 2 Date: 31 Oct 2024
Reviewer:  Jianyang Feng
Reviewer's report:
The authors responded to my initial comment by suggesting that it would be beneficial to
analyze health inequalities across different regions to better understand the findings. However,
instead of conducting an inequality analysis, they only expanded their discussion with additional
references. I am curious if there are any technical challenges that prevent them from performing
such an analysis. If there are, I would appreciate a detailed explanation with compelling
justifications. Numerous published studies have successfully implemented inequality analyses
on related topics (e.g., 10.1177/00220345211056247, 10.1186/s12889-021-11793-7, 10.1016/
j.jadohealth.2023.08.044), including a previous article in BMC Women's Health (10.1186/
s12889-021-11793-7). I maintain that incorporating an inequality analysis is essential for a
more comprehensive interpretation of the current data (10.1016/j.eclinm.2024.102829, 10.1016/
S0140-6736(22)01541-0).
Title: Changing Trends in the Global Burden of Polycystic Ovarian Syndrome-Related
Infertility over the Past 30 Years: Retrospective Data Analysis of the Global Burden of Disease
Study 2019
Version: 3 Date: 29 Nov 2024
Reviewer:  Jianyang Feng
Reviewer's report:
The authors conducted an inequality analysis using the slope index and concentration index,
revealing a significant disparity in the burden of PCOC between regions with low and high SDI.
Additionally, their findings suggested that the gap in disease burden is decreasing, providing
valuable insights for disease control efforts across various SDI regions. Considering all the
comments and responses, I recommend accepting the manuscript for publication.
Title: Changing Trends in the Global Burden of Polycystic Ovarian Syndrome-Related
Infertility over the Past 30 Years: Retrospective Data Analysis of the Global Burden of Disease
Study 2019
Version: 3 Date: 02 Dec 2024
Reviewer:  Yigit Cakiroglu
Reviewer's report:
I would once again thank the authors for the revision of the MS due to suggested revisions.
Title: MEDIATION OF THE EFFECT OF PRENATAL MATERNAL SMOKING ON
TIME TO NATURAL MENOPAUSE IN DAUGHTERS BY BIRTHWEIGHT-FOR-
GESTATIONAL-AGE Z-SCORE AND BREASTFEEDING DURATION: ANALYSIS OF
TWO UK BIRTH COHORTS BORN IN 1958 AND 1970
Version: 1 Date: 12 Jun 2024
Reviewer:  Rebecka Bramsved
Reviewer's report: