JerMa88/BMC_Womens_Health_Peer_Reviews huggingface dataset:
Title: Pattern and trends of the total and age-specific fertility rates during 1990-2018 in Pakistan
Version: 4 Date: 06 Apr 2023
Reviewer:  Marion Burkimsher
Reviewer's report:
The paper was much improved. I was surprised to read in the paper that the stated fertility desire
of women in Pakistan nowadays is 4 children (Table 5). This is very close to the number of
children they actually have - on average. However, I imagine that some have more and others
have fewer than they initially desired. Do you have any insights into who have more and who
have fewer than they might wish? Is there an urban/rural divide?
Title: Pattern and trends of the total and age-specific fertility rates during 1990-2018 in Pakistan
Version: 6 Date: 28 Apr 2023
Reviewer:  Marion Burkimsher
Reviewer's report:
I am happy for the paper to be published.
There are a few issues that should be corrected by proof-reading, eg....
P.4 "own children method" (correct 2nd quotation marks)
p.5 delete "the list of"
P.5 capital Brass P/F
P.6 what are EBs? (write in full before abbreviation)
p.7 right skewed, not rightly
p.7 differs from the standard      & a negative sign (-) for...
p.9 and later pages: check all the table numbers as 2 new tables were added but not all the
numbers in the text were updated
p.15 This sentence needs rephrasing to make sense: However, a significant improved...
p.19 results call for investing in maternal...
Title: The association of parity number with multimorbidity and polypharmacy among
Iranian women in the Azarcohort: A cross-sectional study
Version: 1 Date: 07 Feb 2023
Reviewer's report:
Background: Is important to include deep information from the references 7 to 18.
And I suggest to include a sentence that supports how this cross-sectional study can surpass the
previous ones?
Objective: I suggest removing the phrase “we carried out this novel study” since it is not so.
Results: Is necessary explain in greater detail the results from the logistic regression models.
Discussion: The relevant findings of the study should be presented and contrasted with previous
information, but the information should be analyzed a great depth and not just mentioned.
Bibliography: Review because there are duplicate papers, such as 2 and 38 ([2] Xie Q, Xu H,
Wan Q. Correlation between parity and metabolic syndrome in Chinese women aged 40 years
and older: the Reaction study. BMC Endocrine Disorders 2021;21:1-7 y [38] Xie Q, Xu H, Wan
Q. Correlation between parity and metabolic syndrome in Chinese women aged 40 years and
older: the Reaction study. BMC Endocr Disord 2021;21:236) also 7 y 12 ([7] Moazzeni SS,
Asgari S, Azizi F, Hadaegh F. Live birth/parity number and the risk of incident hypertension
among parous women during over 13 years of follow#up. The Journal of Clinical Hypertension
2021;23:2000-8 y [12] Moazzeni S, Asgari S, Azizi F, Hadaegh F. Live birth/parity number and
the risk of incident hypertension among parous women during over 13 years of follow-up. J Clin
Hypertens 2021;23:2000-8) and 9 and 40 ([9] Moazzeni S, Hizomi Arani R, Asgari S, Azizi F,
Hadaegh F. The association of parity/live birth number  with incident type 2 diabetes among
women:  over 15 years of follow- up in The Tehran Lipid  and Glucose Study. BMC Womens
Health 2021;21:378. [40] Moazzeni SS, Hizomi Arani R, Asgari S, Azizi F, Hadaegh F. The
association of parity/live birth number with incident type 2 diabetes among women: over 15
years of follow-up in The Tehran Lipid and Glucose Study. BMC women's health 2021;21:1-9).
Review the redaction the whole document and with special interest in the bibliography.
Title: The association of parity number with multimorbidity and polypharmacy among
Iranian women in the Azarcohort: A cross-sectional study
Version: 3 Date: 24 Mar 2023
Reviewer's report:
I appreciate the efforts made by the authors to take into account reviewers comments,  to improve
the quality of the manuscript, so I recommend to accept it for publication.
Authors should still revise it to correct the wording of the manuscript (e.g., including spaces
between words).
Title: Differential molecular pathway expression according to chemotherapeutic response in
ovarian clear cell carcinoma
Version: 2 Date: 18 Apr 2023
Reviewer:  Camilla Di Dio
Reviewer's report:
In my opinion, the analyzed topic is interesting enough to attract the readers’ attention. The goal
of this  article was to unravel the molecular alterations among OCCC patients with different
chemotherapeutic response and to obtain insights into potential biomarkers. I think that the
abstract of this article is well organized and clear.
In my opinion, the discussion could be studied in depth and extended. Maybe, it could be
useful the evaluation of the state of the art of what is currently known also about the tumoral
microenviromen and evaluate possible biomarkers of prognosis in association to therapy. Also
could be interesting  the evaluation of bevacizumab vs chemotherapy. In particular I suggest
these two articles, respectively, PMID: 25987014 and PMID: 27794568. Because of these
reasons, the article should be revised and completed. Figures and tables are clear. Considered
all these points, I think it could be of interest for the readers and, in my opinion, it deserves the
priority to be published after minor revisions.
Title: Differential molecular pathway expression according to chemotherapeutic response in
ovarian clear cell carcinoma
Version: 2 Date: 19 Apr 2023
Reviewer:  Ilaria Cuccu
Reviewer's report:
I read with great interest the Manuscript titled " Differential molecular pathways expression
according to chemotherapeutic response in ovarian clear cell carcinoma”, topic interesting
enough to attract readers' attention.
Authors should clarify some points and improve the discussion citing relevant and novel key
articles about the topic:
- I suggest a round of language revision, in order to correct few typos and improve readability.
- The authors could extend the discussion by evaluating how different molecular pathways might
influence the response or eventual resistance to various current therapeutic strategies for ovarian
cancer. For example, I suggest these articles PMID: 22558117 and 32518015.
Considering all these points, I think it could be of interest to the readers and, in my opinion, it
deserves the priority to be published after minor revisions
Title: Differential molecular pathway expression according to chemotherapeutic response in
ovarian clear cell carcinoma
Version: 2 Date: 19 Apr 2023
Reviewer's report:
The manuscript describes actual problem in the molecular context and it is essential to better
understand the loose sensitivity by cells phenomenon.
Although, some changes are required.
1. for all abbreviations please provide the full name at the first used, including genes, i.e. PI3K,
MAPK, NGF, AKT3, CCND2, PDGFRA, CCND1, CCND3, FGF9, FGF11
2. In general, abbreviation of genes please write italic.
3. keywords, please ensure that they come from the mesh database
4. in the introduction, please describe and explain current methods used in diagnostic and
monitoring of the ovarian cancer, i.e. ROMA algorithm: doi: 10.1200/JCO.2003.01.223
doi: 10.1016/j.trac.2018.08.017, doi: 10.1016/j.ejogrb.2018.10.008, doi: 10.1186/
s13048-019-0503-7
5. in the introduction, please cite some works describe the chemotherapy-resistance in the
ovarian cancer, i.e. doi:10.3389/fonc.2022.954008, doi: 10.1080/14737140.2018.1458614
6. Material and methods section should be dived to smaller subsections. I am suggesting: 2.1.
Ethics, 2.2. Patients characteristics including study and control groups (please precise who is
a control) 2.3. RNA isolation, 2.4. Quantitative and qualitative analysis of RNA extracts, 2.5.
Evaluation of changes in the genes expression, 2.6. Stat an.
7. please provide the power analysis. The number of cases seem to be low.
8. Log2FC; 2 in the low index
9. Please better describe the results section, including more data and p-value. Please write genes
in italic.
10. Statistical analysis has to be described precisely. Please add the name of the test used to
assessment normal of the data distribution; Explain when the chi-square test was used and when
the Fisher's exact test was used. Please add descriptive measures for numerical data, i.e., mean,
standard deviation, 95%Cl.
11. Tables and figures have to be self-explanatory.
12. Please provide accession date for each database.
13. "Firstly, the sample size is small due to a less common histological subtype of ovarian cancer.
" - it is not a significant argument for me.
14. Avoid giving statements and conclusions that are not completely supported by the results
of the study.
15. Please read and follow the Instructions for Authors for this journal and format the manuscript
and References correctly.
16. Clearly describe the selection of observational or experimental subjects, inclusion and
exclusion criteria, randomization, and the use of controls.
17. The data acquisition protocol, procedures, investigated parameters, methods of
measurements, and apparatus should be described in sufficient detail to allow other scientists
to reproduce the results.
18. The statistical methods should be described in detail to enable verification of the reported
results.
19. Graphical abstract is mandator to better understand obtained results.
Title: Differential molecular pathway expression according to chemotherapeutic response in
ovarian clear cell carcinoma
Version: 3 Date: 04 May 2023
Reviewer:  Ilaria Cuccu
Reviewer's report:
I read with great interest the Manuscript titled " Differential molecular pathway expression
according to chemotherapeutic response in ovarian clear cell carcinoma”, topic interesting
enough to attract readers' attention.
The quality of the manuscript has improved thanks to the changes made. The methodology is
accurate, and conclusions are supported by data analysis.
Considering all these points, I think it could be of interest to the readers and, in my opinion, it
deserves the priority to be published.
Title: Differential molecular pathway expression according to chemotherapeutic response in
ovarian clear cell carcinoma
Version: 3 Date: 05 May 2023
Reviewer:  Camilla Di Dio
Reviewer's report:
I wanted to thank the authors for making the requested changes and thus broadening and
clarifying the discussion. Thanks to these modifications the article is much more flowing and
clearer and that's why it is deserves the priority to be published
Title: Differential molecular pathway expression according to chemotherapeutic response in
ovarian clear cell carcinoma
Version: 3 Date: 06 May 2023
Reviewer's report:
Dear authors,
Thank you for the careful responses. The revised manuscript is much better than the previous
one. Information and data are suitable, and the statistical methods are appropriate. It deserves
priority to be published after minor revisions regarding the resolution of figures in the
manuscript.
Especially figures 1, 2, and 3 with words and descriptions on the graphs. The words can be
recognized in the present version as a little bit difficult, they are not with the resolution and
clearance of a publication level.
Best regards,
Reviewer 1
Title: Characteristics of Kenyan Women Using HIV PrEP Enrolled in a Randomized Trial on
Doxycycline Postexposure Prophylaxis for Sexually Transmitted Infection Prevention
Version: 2 Date: 10 Dec 2022
Reviewer's report:
Well-written report describing the baseline characteristics of study participants in a randomized-
controlled trial of doxycycline post-exposure prophylaxis to reduce incident bacterial sexually
transmitted infections.
1. Please  review https://pubmed.ncbi.nlm.nih.gov/25515323/ to  see current standards for using
disease names, organism names with italics, abbreviations, etc. Do not use "STI infection(s)"
2. Please add in the Abstract the comparison group--standard of care
3. Is pregnancy monitoring in the trial?  Are newly pregnant participants disenrolled?
4. Please add "years" in Table 1 to describe age
5. Please create a Figure from Table 3.  Would be easier for readers to interpret
6. Which doxycycline formulation is being use?  Hyclate or monohydrate
7. Any baseline measures of common doxy side effects (nausea, appetite loss, etc) in the prior
3 months
Title: Characteristics of Kenyan Women Using HIV PrEP Enrolled in a Randomized Trial on
Doxycycline Postexposure Prophylaxis for Sexually Transmitted Infection Prevention
Version: 2 Date: 28 Dec 2022
Reviewer's report:
This is a well written, straightforward description of the characteristics of Kenyan women
enrolled in the Doxy PEP trial.  It clearly explains why these women would benefit from the
intervention, documents their behaviors which put them at risk for STIs and HIV, and presents
baseline STI data.
Title: Characteristics of Kenyan Women Using HIV PrEP Enrolled in a Randomized Trial on
Doxycycline Postexposure Prophylaxis for Sexually Transmitted Infection Prevention
Version: 5 Date: 07 Apr 2023
Reviewer:  Gift Kamanga
Reviewer's report:
Dear Authors
This is a great paper which has very important role to play in public health for those exposed to
STIs and PrEP users. My comments for consideration and clarification are as follows;
1.  Consider editing the study topic to qualify on the type of women. "... Kenyan Women
using PrEP who were enrolled in…" This is because if the study was open to all young women
regardless of PrEP status, the dynamics may have been different.
2. On use of contraceptives, the authors should clarify whether or not they explored for
natural calendar family planning method?  The statement that "...One hundred women (22.3%)
reported not using any contraceptive method." may only mean people were no using modern
contraceptive methods.
3. On discussion, there is this statement "Despite the high frequency of sexual activity, not
all study participants reported prior live births, and of the 137 women (30.5%) without prior
delivery, 100 (72.5%) were not using hormonal contraception at enrolment".  Need to be cautious
with this assumption because the issue no history of live births may be intentional to some
people. Some young women may have intentionally not chosen to give birth because they are
currently in school. (I am not sure if researchers asked whether some people were currently in
school or not) 2. Some may have a deliberately delayed fertility intention due to some other
factors. There is growing shift of age before people decide to have first child around that age
group.
Title: Characteristics of Kenyan Women Using HIV PrEP Enrolled in a Randomized Trial on
Doxycycline Postexposure Prophylaxis for Sexually Transmitted Infection Prevention
Version: 5 Date: 10 Apr 2023
Reviewer's report:
General Comments:
-The manuscript may benefit from one more grammatical review to correct some minor changes
that need to be made.
Introduction:
-Please be consistent with the intended adverse impacts of STIs on pregnancy (i.e., preterm labor
and  preterm delivery). Please see related comment in the Discussion section).
Methods:
-References are needed for the various HIV and STI tests that are mentioned, lines 120-133.
Results:
-The numbers (<10) in the text need to be spelled out, lines 193, 195, 217.
Discussion:
-Lines 232-236: please mention that the infertility can be related STI infection.
-Lines 231-232: Please be consistent with the contribution of STIs to preterm labor, preterm
delivery and fetal/neonatal demise. Additional references will need to be added.
Declarations:
Line 259: "...guidelines and regulations of the Kenyan Ministry of Health."
Title: Prevalence and genotype screening of human papillomavirus among women attending a
private hospital in Northern Cyprus: an 11-year retrospective study
Version: 1 Date: 12 Apr 2023
Reviewer:  Giorgio Bogani
Reviewer's report:
I read with great interest the Manuscript titled "Prevalence and genotype screening of human
papillomavirus among women attending a private hospital in Northern Cyprus: an 11-year
retrospective study" which falls within the aim of the Journal.
In my honest opinion, the topic is interesting enough to attract the readers’ attention.
Methodology is accurate and conclusions are supported by the data analysis. Nevertheless,
authors should clarify some point and improve the discussion citing relevant and novel key
articles about the topic.
- I suggest another round of language revision, in order to correct few typos and improve
readability.
-The introduction should be extended and completed. I find interesting to include a reference to
the risk factors predicting HPV recurrence (see PMID: 36992282; 36918227).
-inclusion/exclusion criteria should be better clarified by extending their description.
- I also suggest authors to  better organize the discussion section following this ideal structure:
main findings of the study, strength and limitations of the study, implications and comparison
with literature, future directions.
- Discussions can be expanded and improved by citing relevant articles (I suggest authors to
read and insert in references the following article PMID: 36141917; 35909005).
Title: Prevalence and genotype screening of human papillomavirus among women attending a
private hospital in Northern Cyprus: an 11-year retrospective study
Version: 1 Date: 12 Apr 2023
Reviewer:  Ilaria Cuccu
Reviewer's report:
In my opinion, the analyzed topic is interesting enough to attract the readers’ attention. The
aim of this study was to evaluate the HPV type-specific prevalence in women with and without
cytological abnormalities living in Northern Cyprus.
I think that the abstract of this article is very clear and well structured.
In my opinion, the discussion could be studied in depth and extended. Maybe, it could be useful
the evaluation of the state of the art of possible algorithms or prevention of cervical cancer .
Also, it could be interesting the analyzing the surgical outcomes and consequences of surgery in
woman with cervical cancer in order to sensitize woman to prevention. In particular, I suggest
these articles to get deeper in the topic, respectively: PMID: 35455328, PMID: 36293758.
Because of these reasons, the article should be revised and completed. Figures are clear and
interesting. Considered all these points, I think it could be of interest for the readers and, in my
opinion, it deserves the priority to be published after minor revisions.
Title: Prevalence and genotype screening of human papillomavirus among women attending a
private hospital in Northern Cyprus: an 11-year retrospective study
Version: 1 Date: 15 Apr 2023
Reviewer:  Georgios Michail
Reviewer's report:
This retrospective single-center study utilized material collected from women attending
gynecological clinics of a private Hospital in Northern Cyprus throughout an 11-year period. The
aim of this study was to provide insights into the local prevalence of HPV in Northern Cyprus,
a region in which free immunization is not accessible, by documenting the HPV frequency
and genotype distribution. The authors claim that the study was exempt from patient informed
consent; this statement warrants verification.
The >55 age group is vastly underrepresented (n=13, 3.3%) in this study.
The study is well composed and the Discussion section in particular is comprehensive. Tables
and Figures are adequate, albeit simple. The Results should be interpreted with caution,
considering possible bias, since the study has several limitations, several of which are identified
by the author’s:
1) Detection of specific genotypes in the “Other high-risk HPV types” pool was not possible;
therefore the dominant prevailing HPV genotypes could not be identified. In this perspective,
validated assays providing extended genotyping would be more suitable.
2) It is not totally clear if the “gynecological clinics” from which the material was harvested also
comprised colposcopy clinics, to account for the considerable (44.3%) overall high-risk HPV
prevalence (row 171). The authors state that the sample population mostly consisted of patients
that had attended the hospital as a consequence of having HPV related symptoms or cervical
abnormalities, acknowledging this might lead to selection bias.
3) The vaccination status of the participants was unknown. Uncertainties re vaccination status
and possible herd effects a decade after the launch of the anti-HPV vaccine are confusing;
definitely these will not allow the study to be considered as a benchmark study reflecting the
HPV epidemiology in a naïve population, well before the introduction of the HPV vaccine.
[Nonetheless, even in settings with “opportunistic” HPV vaccination, linkage with registries
should be able to identify vaccinated individuals].
4) The implementation of two different assays for partial HPV genotyping purposes throughout
the study period, while anticipated for a single center study with prolonged follow-up, might
inevitably cause variability in the results.
Title: Prevalence and genotype screening of human papillomavirus among women attending a
private hospital in Northern Cyprus: an 11-year retrospective study
Version: 2 Date: 07 May 2023
Reviewer:  Ilaria Cuccu
Reviewer's report:
I read with great interest the Manuscript titled " Prevalence and genotype screening of human
papillomavirus among women attending a private hospital in Northern Cyprus: an 11-year
retrospective study”, topic interesting enough to attract readers' attention.
The quality of the manuscript has improved thanks to the changes made. The methodology
is accurate, and conclusions are supported by data analysis. The discussions are clear and
comprehensive. References are relevant to the search
Considering all these points, I think it could be of interest to the readers and, in my opinion, it
deserves the priority to be published.
Title: Prevalence and genotype screening of human papillomavirus among women attending a
private hospital in Northern Cyprus: an 11-year retrospective study
Version: 2 Date: 11 May 2023
Reviewer's report:
The authors mostly made the requested corrections. With minor changes, I would recommend
the paper for publication. Please note the following points:
-From line 164 and beyond, it was recommended to write rtPCR instead of RT-PCR (RT -written
in caps means Reverse Transcription!). Make changes at every mention of the abbreviation in
the manuscript, please.
- Line 184- Typo- Sasace... Sacace
- Line 188- " Only qualitative results were taken into consideration." It is ok now in the
manuscript, but you wrote "quantitative" in response to the reviewer, probably by mistake.
- Figure 2- Visually, it would be better if the authors changed the chart's orientation by rotating
it clockwise by 90°. Thus, the % values will be outside the columns on the right and will be
clearly readable.