Title: Predictive Modeling of Postoperative Gastrointestinal Dysfunction: The Role of Serum
Bilirubin, Sodium Levels, and Surgical Duration in Gynecological Cancer Care
Version: 6 Date: 20 Aug 2023
Reviewer's report:
Dear [Corresponding Author,
I hope this message finds you well. I have completed a thorough review of the manuscript
titled"Main Predictive Factors Identified in Postoperative Gastrointestinal Dysfunction in
Gynecological Cancer Patients" . Overall, I find the study's focus on predictive factors for
postoperative gastrointestinal dysfunction in gynecological cancer patients to be highly relevant
and potentially impactful. However, there are several areas that could benefit from improvement
to enhance the clarity, rigor, and overall impact of the study.
Title:
The title "Main Predictive Factors Identified in Postoperative Gastrointestinal Dysfunction in
Gynecological Cancer Patients" effectively conveys the study's focus. To enhance specificity
and engagement, consider a title like:
"Unveiling Key Predictors of Postoperative Gastrointestinal Dysfunction in Gynecological
Cancer: Insights for Personalized Management Strategies"
Abstract:
The abstract could benefit from clearer organization into distinct sections: "Objective,"
"Methods," "Results," "Conclusion," and "Keywords."
1. Objective: Make the study's purpose explicit – identifying predictive factors for postoperative
gastrointestinal dysfunction in gynecological cancer patients and developing a combined
predictive model.
2. Methods: Expand on data collection, patient selection criteria, and statistical methods used.
Mention ethical approvals or IRB oversight for a retrospective study involving patient data.
3. Results: Provide specific numerical results, p-values, and a clearer presentation of statistical
findings.
4. Conclusion: Highlight clinical relevance, potential impacts on patient care, and acknowledge
limitations.
Introduction:
1. Citations:Include proper citations for statistics and claims presented to enhance credibility.
2. Context:Briefly mention prevalence or incidence rates of postoperative gastrointestinal
dysfunction in gynecological cancer patients to provide context.
3. Clear Objectives: Explicitly state the study's aim of identifying predictive factors for POGD
and developing a combined predictive model.
Materials and Methods:
1. Inclusion and Exclusion Criteria: Provide detailed inclusion and exclusion criteria, including
the rationale for choices.
2. Variables Justification: Justify the inclusion of specific variables in the study.
3. Ethical Considerations: Mention ethical approvals or IRB oversight for conducting a
retrospective study involving patient data.
Statistical Analysis:
1. Interpretation of Results:Clarify implications of odds ratios and confidence intervals for
practical significance.
2. Multicollinearity: Address potential multicollinearity among variables.
3. Data Handling: Discuss missing data handling techniques and procedures for addressing
biases from missing data.
Results:
1. Statistical Presentation:Offer detailed descriptions in text to interpret significance and clinical
relevance of findings.
2. Outliers: Discuss handling of outliers and their impact on results' reliability.
3. Interpretation of Odds Ratios: Explain clinical implications of odds ratios for better
understanding.
4. Clinical Relevance: Elaborate on findings' impact on patient outcomes and treatment
strategies.
5. External Validation: Mention need for external validation of predictive model.
6. Confounding Factors: Discuss how potential confounding factors were addressed or their
impact on results.
7. Comparative Discussion:Compare results with existing literature or similar studies.
8. Sample Size and Generalizability: Address limitations of sample size and patient population.
9. Multicollinearity and Interaction Effects: Discuss potential multicollinearity or interaction
effects.
10. Sensitivity Analysis: Consider performing sensitivity analyses.
Discussion:
1. Contextualization: Compare findings with existing literature for better contextualization.
2. Language: Simplify language for clarity.
3. Anesthesia Time: Explore implications of longer anesthesia times.
4. Clinical Mechanisms: Explain mechanisms in depth based on existing research.
5. Surgical Approach Influence: Discuss influence of different surgical approaches.
Conclusion:
1. Reiteration of Findings: Re-emphasize findings and broader implications.
2. Future Directions: Elaborate on specific areas for future research.
3. Practical Application: Discuss practical implementation of personalized strategies.
4. Ethical Considerations: Touch on ethical implications of using patient data.
5. Overall Impact: Conclude with strong statement about study's potential impact.
References:
1. Incomplete Citations: Ensure all references have complete and accurate information.
2. Format Consistency: Maintain consistent formatting throughout the reference list.
3. Missing DOIs:Include DOIs for journal articles.
4. Recent References: Incorporate more recent references.
5. Abbreviations: Spell out abbreviations at first mention.
6. Online Publications: Include URLs for online sources.
I understand that revising the manuscript may require additional effort, but these
recommendations are aimed at improving the quality and impact of your study. Your efforts
to address these points will certainly enhance the value of your work for both the scientific
community and clinical practitioners.
If you have any questions or need further clarification on any of these recommendations, please
do not hesitate to reach out. I look forward to reviewing the revised manuscript.
Best regards,