Reviewer’s report
Title: 
Use of trastuzumab in treating breast cancer during pregnancy: a
systematic review and meta-analysis
Version: 
0 
Date: 
23 Jun 2020
Reviewer's report:
Interesting subject with limited evidence available based on 22 case reports
The authors should revise this paper:
I have the following comments
page 2 line 39-42: refrase
page 4 line 63-65: refrase
page 5: line 107: which type of endocrine therapy ?
page 6 line 117: what about risk for spontaneous abortion, this is not always
captured by a collection of case reports
page 7 lines 118-125: differences are not significant with wide levels of
confidnece: SO THERE IS NO CORRELATION statistically. This should be
refrased in the abstract, results and discussion section
In general the authors minimize the effect of tratuzumab during pregnancy. The
limitations of this paper should be clearly stated: limited number of case reports,
possible publication bias. In principle this tretament is contraindicated during
pregnancy and potential benefitts for the mother should be abalnced against the
risks for the. Option for termination of pregnancy. This should be discussed in a
balanced way in the discussion section
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No
Are the methods appropriate and well described?
If not, please specify what is
required in your comments to the authors.
No
Does the work include the necessary controls?
If not, please specify which
controls are required in your comments to the authors.
Unable to assess
Are the conclusions drawn adequately supported by the data shown?
If not,
please explain in your comments to the authors.
No
Are you able to assess any statistics in the manuscript or would you
recommend an additional statistical review?
If an additional statistical review
is recommended, please specify what aspects require further assessment in your
comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the
manuscript:
Not suitable for publication unless extensively edited
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