Reviewer’s report
Title: 
Primary ovarian serous carcinomas with extensive squamous differentiation : A case report and l
iterature review
Version: 
0 
Date: 
17 Mar 2021
Reviewer's report:
This is an interesting case of HGSOC with squamous differentiation. Squamous differentiation is
commonly observed in endometrioid ovarian cancer but not in HGSOC. I have the following comments:
1. How many patients are diagnosed with ovarian cancer in the authors' institution each year?
2. Were the slides examined by an independent expert gyn pathologist?
3. Ovarian endometrioid carcinomas can be regarded as 'low grade' and most 'high-grade' carcinomas with
endometrioid features would be regarded as HGSOC. Could the authors discuss further about the
distinction between HGSOC and endometrioid carcinomas from the histologic point of view? What are
the differences in immunohistochemical profile?
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