Reviewer’s report
Title: 
CCDC114, DNAI2 and TOP2A  involves in the effects of Tibolone
treatment on postmenopausal endometrium
Version: 
0 
Date: 
27 Jan 2020
Reviewer: 
Longla Acheliu
Reviewer's report:
Generally, the subject of interest is an interesting topic for research and the
manuscript is well organized and coherent. Nevertheless, there are a couple of
shortcomings that I think is important to address. First of all, there are are some
mistakes in the language used in this write-up, mainly tenses and and sentence
structure that needs to be rectified. 
Secondly, the METHODOLOGY is quite difficult to comprehend and I noticed
the following issues that needs amendments:
- it does give us an idea of how the samples were collected. Nine samples were
collected for each group as you mentioned but are these samples from 9 different
women implying one sample per person? Also how were the samples collected
- There methods section does not give us the types of variables that were found
in the data set and whether they are continuous or categorical. 
So I think after clarifying these, the methods section will be better so that we can
also tell if the statistical methods used were appropriate. 
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
No
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the
authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you
recommend an additional statistical review?
If an additional statistical review is recommended, please specify what aspects
require further assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
Declaration of competing interests
Please complete a declaration of competing interests, considering the following
questions:
1
. 
Have you in the past five years received reimbursements, fees, funding, or
salary from an organisation that may in any way gain or lose financially
from the publication of this manuscript, either now or in the future?
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gain or lose financially from the publication of this manuscript, either now
or in the future?
3
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Do you hold or are you currently applying for any patents relating to the
content of the manuscript?
4
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Have you received reimbursements, fees, funding, or salary from an
organization that holds or has applied for patents relating to the content of
the manuscript?
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Do you have any other financial competing interests?
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. 
Do you have any non-financial competing interests in relation to this
paper?
If you can answer no to all of the above, write 'I declare that I have no competing
interests' below. If your reply is yes to any, please give details below.
I declare that I have no competing interests
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