Reviewer’s report
Title: 
COMPARATIVE COST ANALYSIS OF CERVICAL CANCER
SCREENING PROGRAMME BASED ON MOLECULAR DETECTION OF
HPV IN SPAIN
Version: 
0 
Date: 
04 Aug 2020
Reviewer's report:
This cost analysis compared the total costs of cervical cancer screening with a
primary HPV test based on the detection of mRNA compared to DNA in women
aged 35-65 years for the Spanish National Health System. This is a well
designed and well written study. It provides insight for efficient use of health
resources with regards to cervical cancer screening in Spain. This study is
important since it will aid health decision making in Spain. I made minor
observations which the authors need to consider:
Abstract Section
Result s: The authors stated" The use of AHPV avoided 151,699 (-47%) and
151,165 (-47%) colposcopies and 290,541 (-35%) and 355,913 (-40%) LBC vs
HC2 and Cobas, respectively; and allows saving €- 39,839,711 vs HC2 and €-
41,866,613 vs Cobas". This is very difficult to comprehend. Authors should re-
write this section and use simple sentences rather than compound sentence.
Method Section
To aid comprehension, the authors should add a diagram to give a graphic
illustration of screening interventions compared in the analysis the analysis
To authors should give reasons for using decision tree model, since it is a
requirement of the CHEERS statement.
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Is the study design appropriate to answer the research question (including the use
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