Reviewer’s report
Title: 
The effect of mobile-app-based instruction on the physical function of
female patients with knee osteoarthritis: a parallel randomized controlled trial
Version: 
0 
Date: 
07 Mar 2021
Reviewer's report:
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In the manuscript under review, the authors present a clinical study about the
effect of mobile-app-based instruction on the physical function of female
patients with knee osteoarthritis by using a parallel randomized controlled trial,
the conclusion is the use of mobile-app-based instruction can enhance the
physical function and quality of life in patients with knee osteoarthritis. 
A few comments on the manuscript are as follows:
1.Why all the participants are female patients?
2.The study is a RCT, but how the patients were assigned to different groups?
The study used blindness method to the reseacher who collected information,
and patients were planned to be visited on different days in the following visit,
so how to make sure the reseacher did not know which group the patient
belonged. 
3.Why there is no P value in the table 1 about participant characteristics.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
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from apparent manipulation?
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