Reviewer’s report
Title: 
Frequency and Clinical Characteristics of HER2 over-expressed Breast
Cancer in Saudi Arabia: A Retrospective Study
Version: 
0 
Date: 
02 Sep 2020
Reviewer's report:
Totally the present article is well-established and the subject is interesting, but
some major revision should be considered.
- More suitable title should be selected for the article. 
- The abstract should state briefly the purpose of the research, the principal
results and major conclusions. An abstract is often presented separately from the
article, so it must be able to stand alone.
- It is suggested to present the structure of the article at the end of the
introduction.
- The necessity and innovation of the article should be presented to the
introduction.
- The major defect of this study is the debate or Argument is not clear stated in
the introduction session. Hence, the contribution is weak in this manuscript. I
would suggest the author to enhance your theoretical discussion and arrives your
debate or argument.
- Sections and sub-sections should be numbered in order.
- More suitable title should be selected for the table 3 instead of "Hormone-
receptor status in HER2 positive Breast Cancer Patients".
- Following, you will find some new related references which should be added to
literature review:
Mohd-Nor & Bit-Lian. Knowledge, Attitude and Practices of Standard
Precaution among Nurses in Middle-East Hospital;
Kosvyra et al. Developing an Integrated Genomic Profile for Cancer Patients
with the Use of NGS Data;
Zare, H. Effects of Salvia Officinalis Extract on the Breast Cancer Cell Line.
- Page 8: the following paragraph is unclear, so please reorganize that:
"Patients with no survival data at time of assessment were censored and patients
who had not received pharmacotherapy were excluded from the OS and PFS
analyses. The frequency of AEs was summarized according to the System Organ
Classification (SOC) and within each SOC, by MedDRA preferred term."
- Much more explanations and interpretations must be added for the results,
which are not enough.
- It is suggested to compare the results of the present research with some similar
studies which is done before.
- Please make sure your conclusions' section underscore the scientific value
added of your paper, and/or the applicability of your findings/results, as
indicated previously. Please revise your conclusion part into more details.
Basically, you should enhance your contributions, limitations, underscore the
scientific value added of your paper, and/or the applicability of your
findings/results and future study in this session.
- DOI of the references must be added (you can use "https://crossref.org/").
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes