Reviewer’s report
Title:  Effects of exercise on Inflammatory Factors and IGF System in Breast Cancer Survivors: A
Meta-analysis
Version: 2 Date: 20 Jul 2022
Reviewer's report:
Thank you to the authors for kindly addressing each comment. I do believe that the authors did address
most of the comments adequately. However, I do still have reservations about the manuscript in its
current form. 1) I do believe that there is a lot of good information in this paper. However, it is very
hard to follow. It is highly suggested, as it has been in previous reviews, that the authors continue to
consult to work on the overall flow and grammatical structure of the paper. In its current form, it is very
hard to follow at times and is not clear as to what the message(s) are in certain paragraphs or their
purpose. This applies to all sections within the document. 2) I do believe that the Discussion section
still  requires  major  revisions.  Authors  have  addressed  previous  comments  and  included  more
comparisons and speculation to their findings. However, this section still reads as if it is an in depth
literature review at times, which ultimately detracts from their sections that compare and speculate on
their own findings. It is strongly suggested that the authors streamline their discussion section. Again,
overall the authors did address most comments. But I do believe that how the manuscript reads in its
current form still precludes it from publication. It is strongly suggested that authors revise their paper
for overall grammar and flow of the document because as it reads now, it is very hard to follow. As a
result, both the rationale and key takeaways from the article are not clear. I believe if authors work on
the overall grammatical structure and flow of the manuscript, these aspects will become much more
clear.
Publons Reviewer Recognition . Springer Nature can send verification of this review  directly to
Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please
click on the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of
the journal, and date of your review submission (the “Review Data”) will then be transmitted to
Publons after the final decision on the manuscript has been made. If you have already registered at
Publons, they will notify you of the receipt of this review and update your profile as per your settings
and their policy. If you are not registered with Publons, you will receive an email from them asking you
to register in order for them to be able to recognize your review on your new profile page. Publons may
use the Review Data to generate derivative metadata for the benefit of Publons and you as a reviewer,
carefully considering the sensitivity of such information. For example, Publons may verify your record
as a reviewer by updating your profile published on its webservice if you have registered for such
service or help editors to identify candidate reviewers. Please find the details of processing in Publons’
privacy policy https://publons.com/about/terms
Yes
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of this
manuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?
6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below. If
your reply is yes to any, please give details below.
I declare that I have no competing interests
I agree for my report to be made available under an Open Access Creative Commons CC-BY License
(http://creativecommons.org/licenses/by/4.0 )  if  this  manuscript  is  accepted  for  publication.  Any
comments that I do not wish to be included in the published report have been included as confidential
comments to the editor, which will not be published. If you are not happy for us to publish this report,
please contact the editorial office before completing the review. If you wish, you can include your
name in your published report. Please note you must decide whether to include your name at the start
of the process and confirm this decision whenever prompted. If you change your decision later, we will
not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report. (default)
Is the study design appropriate to answer the research question (including the use of appropriate
controls), and are the conclusions supported by the evidence presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
No
Are  the  images  in  this  manuscript  (including  electrophoretic  gels  and  blots)  free  from  apparent
manipulation?
Yes