Reviewer’s report
Title: 
First case of endometrial cancer after yolk sac tumor in a patient with Li-
Fraumeni Syndrome
Version: 
1 
Date: 
23 Feb 2023
Reviewer's report:
REVISION ASSESSMENT FROM THE ACADEMIC PEER REVIEWER: 
Has the author addressed your concerns sufficiently for you to now recommend
the work as a technically sound contribution? Yes
Reviewer comments: Most of the major queries were adequately addressed by
the authors in the revised version. Additional minor changes are suggested below
to further improve the manuscript clarity for the readers :
Minor wording changes
-Line 78 : Please describe "comprehensive staging laparotomy with fertility
preservation" in more details. Name the exact procedure. Furthermore, I would
say that this approach was "chosen" rather than "feasible".
-Line 79-80 : Not clear what the authors mean by "While the patient's family
requested waiting for the paraffin pathological results and refused to perform
further comprehensive staging laparotomy" . Please clarify. Was the family
consulted intraoperatively to decide what procedure would be performed ?
-Line 83 :The authors reported "She refused a second operation".... what
operation was recommended as a second operation ??
-Line 84 :Not sure what "compensated chemotherapy" mean ? Please clarify
-Line 86 : please provide normal range of AFP at the authors' institution 
-Line 107-8 : to be clear I suggest just say "tumor was completely excised
without
gross residual tumor...."
-Line 122-3 : please clarify what is the plan for Bevacizumab treatment ? Until
progressive disease ?? Also I would suggest saying " ...now she is receiving
bevacizumab-targeted therapy once a month as a meta-analysis showed there
were significant differences in progression-free survival....."
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presented?
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