JerMa88/BMC_Womens_Health_Peer_Reviews huggingface dataset:
Title: Detection of cervical high-grade squamous intraepithelial lesions and assessing diagnostic
performance of colposcopy among women with oncogenic HPV
Version: 1 Date: 18 Jun 2023
Reviewer:  Shih-Tien Hsu
Reviewer's report:
This article discusses the immediate risk of CIN 2+ among women with oncogenic HPV types
and the performance of colposcopy in diagnosing histologic CIN2+ in these women at Putuo
Hospital in Shanghai, China. While the aim is clear and the results are informative, there are
some issues regarding the background and results that should be addressed.
1. The authors state that patients with high-risk HPV at Putuo Hospital were included, but not all
patients received pap smear and further colposcopy. This introduces a significant bias. It would
be important for the authors to provide the numbers of cases that were not included in this study
but had high-risk HPV infection. Additionally, it would be helpful to know if any guidelines or
flowcharts were followed in selecting patients for inclusion.
2. For follow-up and screening purposes, between February 2020 and December 2022, some
cases may have received multiple HPV tests. It would be beneficial to understand how the
authors managed the data in such cases.
3. The ATHENA and IMPACT trials were conducted using the same HPV testing system and led
to changes in guidelines worldwide. However, the results regarding non-16/18 high-risk HPV
infections were not consistent. The percentage of CIN2+ reported in this study was higher. It
would be valuable for the authors to explain the difference and provide possible reasons for it.
4. The exclusion criteria in this study included a known history of cervical lesions or cervical
cancer, pregnancy, hysterectomy, or radiotherapy. It would be helpful to clarify the definition
of a history of cervical lesions. Were previous abnormal pap smears excluded?
5. Based on the results of this article, has any new risk-based management algorithm using HR-
HPV genotyping and cytology been established or suggested?
Title: Detection of cervical high-grade squamous intraepithelial lesions and assessing diagnostic
performance of colposcopy among women with oncogenic HPV
Version: 1 Date: 19 Jun 2023
Reviewer:  Giorgio Bogani
Reviewer's report:
I read with great interest the manuscript, which falls within the aim of this Journal and offers a
high-quality overview of the topic.  Indeed, the topic is of the utmost importance given the efforts
made by the WHO for the prevention and early diagnosis of cervical cancer and precancerous
cervical lesions.
Although the manuscript can be considered already of high quality, I would suggest to take into
account the following minor recommendations:
- I suggest another round of language revision, in order to correct few typos and improve
readability.
-The introduction should be extended and completed. I find interesting to include a reference
to the risk factors that influence outcomes of patients surgically treated for high-grade cervical
dysplasia (PMID: 36992282).
- Methodology is not accurately reported. Inclusion/exclusion criteria should be better clarified
by extending their description; the statistical analysis needs to be clarified by mentioning tests
used to compare variables where appropriate.
- I find interesting to include a reference about the long-term outcomes of patients with cervical
cancer treated with different approaches (open vs mini-invasive) (see PMID: 37149905).
- The authors have not adequately highlighted the strengths and limitations of their study. I
suggest better specifying these points.
Title: Detection of cervical high-grade squamous intraepithelial lesions and assessing diagnostic
performance of colposcopy among women with oncogenic HPV
Version: 1 Date: 20 Jun 2023
Reviewer:  Andrea Etrusco
Reviewer's report:
In my opinion, the analyzed topic is interesting enough to attract the readers’ attention.I think
that the abstract of this article is very clear and well structured.
In my opinion, the discussion could be studied in depth and extended. Maybe, it could be useful
the evaluation of the outcomes of this condition in relation to the treatment. This could highlight
the importance of early  diagnosis and colposcopy.  In particular, I suggest these articles to get
deeper in the topic: PMID: 33140628 and PMID: 36293758. Because of these reasons, the article
should be revised and completed. Considered all these points, I think it could be of interest for
the readers and, in my opinion, it deserves the priority to be published after minor revisions.
Title: Detection of cervical high-grade squamous intraepithelial lesions and assessing diagnostic
performance of colposcopy among women with oncogenic HPV
Version: 3 Date: 10 Jul 2023
Reviewer:  Giorgio Bogani
Reviewer's report:
I read with great interest the Manuscript titled “Detection of cervical high-grade squamous
intraepithelial lesions and assessing diagnostic performance of colposcopy among women with
oncogenic HPV”, topic interesting enough to attract readers' attention
The quality of the manuscript has improved thanks to the changes made. I think it could be of
interest to the readers and, in my opinion, it deserves the priority to be published.
Title: Investigation of the interaction between genetic risk score (GRS) and fatty acid quality
indices on mental health among overweight and obese women
Version: 1 Date: 10 May 2023
Reviewer's report:
Overall, the manuscript could be accepted with minor revisions, and the author(s) need to clearly
state the urgency of the study, as well as complete more details and discussions.
1. Abstract
- Need to add abbreviation captions
2. Introduction
- The urgency of the study has not been made clear
- We suggest to explain the definition of N6/N3 ratio at the beginning
3. Materials and methods
- What is the criteria of obesity and overweight used in the study? Please explain more
- How was the IPAQ form filled out? Did the subject fill in on his own or through an interview?
- We suggest to explain every biomarkers analyzed in the study
- How was the data on the quantity of food consumed obtained? Were there any tools to describe
or equalize perceptions of the food portions?
4. Results
- Are there any correlations between HOMA index and FBS with N6/N3 ratio?
5. Discussion
- What is the role of N6/N3 ratio to FBS and HOMA-IR?
- We suggest the author to explain more about the relation of CRP, inflammation, and N6/N3
ratio
- Are there any relevancies related to GOT and GPT in this study because they are mentioned
in the table?
Title: Investigation of the interaction between genetic risk score (GRS) and fatty acid quality
indices on mental health among overweight and obese women
Version: 1 Date: 22 May 2023
Reviewer's report:
I sincerely appreciate the important studies on the relationship between GRS and fatty acids and
the mental health of obese and overweight women. I do, however, have a few inquiries.
- Why were N6/N3 (279) and CSI (378) examined independently? Although each group was
recruited individually, could you not tell the difference between CSI and N6/N3 in the same
meal? I believe that more explanation is required.
- It makes sense, in my opinion, to consider the interactions of the three genes in  GRS:  CRY,
Mc4R, and CAV as variables. However, it is advised to include a description of each of these
genes or a summary of the relevant findings in the DISCUSSION section.
Title: Pathways to medical abortion self-use (MASU): Results from a cross-sectional survey of
women's experiences in Kenya and Uganda
Version: 5 Date: 09 May 2023
Reviewer:  Sarah Raifman
Reviewer's report:
The authors explain in their comments that they did not administer a survey, but rather collected
data from medical registries. This is helpful for clarification. I think the word "survey" should
be avoided in the manuscript to avoid confusion. "Survey" is used in the title and throughout
the methods sections to refer I think to the study as a whole. Perhaps use of the word "study"
instead of "survey" would be helpful to clarify.
Title: Vitamin D and Vitamin D receptor polymorphism in Asian Adolescents with primary
dysmenorrhea
Version: 3 Date: 27 May 2023
Reviewer's report:
In this study, authors investigated the relation between serum 25(OH)D and PD, and the odds
of PD in Asian adolescents with TaqI (rs731236) polymorphism. They reported lower serum
25(OH)D levels in the studied-dysmenorrhea group compared to controls. Also, they reported
lower serum 25(OH)D levels in studied-dysmenorrhea cases with T/t and t/t TaqI genotypes
compared to controls.
The following suggestions must be made:
- There are many sentence structure and grammatical errors in the article. The English of the
article should be corrected by a native English speaker.
-The hypothesis should be written in the last paragraph of the introduction.
-It should be stated whether the study is prospective.
-Power analysis is incomprehensible. Why is the number of patients so high?
-The discussion section needs to be reorganized. The results of the study should be discussed
and compared with the results of similar studies in the literature.
As a result, minor revision is recommended.
Sincerely yours…
Title: “I think to myself ‘why now?’” – a qualitative study about endometriosis and pain in
Austria
Version: 2 Date: 21 May 2023
Reviewer:  Emanuela Spagnolo
Reviewer's report:
In this manuscript, the authors proposed a quality research on endometriosis patients.
The topic is of interest, but several aspects must be pointed out.
The study is confused and the aims are not clear. In Methods section, the authors have to specify
the type of the study (for example observational study).
The sample size is to small (only 10 patients).
I suggest the authors to schematize the results and to report the answers to all categories.
It could be interesting to describe the following characteristics:
endometriosis stage and type of the patients included in the study; medical/surgical treatment;
IVF/spontaneous pregnancy.
Furthermore, the association between the previous data and interview’s fundings should be
analysed.
Title: “I think to myself ‘why now?’” – a qualitative study about endometriosis and pain in
Austria
Version: 2 Date: 04 Jun 2023
Reviewer's report:
I read with great interest the manuscript, which falls within the aim of this Journal. In my honest
opinion, the topic is interesting enough to attract the readers’ attention. Authors should consider
the following recommendations: - Manuscript should be further revised in order to correct some
typos and improve style.
- It would be appreciable a small topic on the problem of central sensitization in women with
endometriosis referring to doi 10.1016/j.jmig.2022.10.007
- Moreover another topic  that could affect the quality of life of women with endometriosis
is the impact of infertility and low obstetric outcomes referring to: PMID: 36431203 ; PMID:
34623489 PMID: 34096691. Make a comment.
Title: Management of encounters related to subfertility and infertility in Australian general
practice: a focus on Aboriginal and Torres Strait Islander females
Version: 3 Date: 18 May 2023
Reviewer:  Cynthia Porter
Reviewer's report:
Thank you for the opportunity to review your paper.
This is an extremely important area of general practice thank you for your research.
The topic and title are appropriate for the study. Ethics are acknowledged.
The paper is constructed to read concisely and the flow  and language  are crafted well.
The study methodology is sound as is the analysis of the data.  There is a methodical approach to
the results and the tables are clear and easy to read.  The references are extensive and appropriate
with recent  peer reviewed data provided.
The strengths and limitations are are listed. However the major limitation to this study is the
lack of ACCHO and AMS data. This should be the  first and major limitation of the study.
More information would be useful as to ATSI women attending an AMS to the comparator of
rural/ regional  vs remote vs metropolitan GP services.    From my experience working in a
rural/ remote location the majority of ATSI  women attend AMS or an ACCHO based medical
Centre rather than a private GP practice.   Mostly due to financial restraints but also the other
barriers you accurately identified, such as cultural safety.   This is evident in the paper reference
#4 by Kildea  et al, in the Northern Territory, with infertility being as high as 26% vs your data
of 12.4%.
It would be interesting to know if education and career advancement is delaying pregnancy and
thus increased risk of infertility as seen in non ATSI data.  Is it the same for ATSI women based
in the Metropolitan area vs rural/  regional/ remote areas?
What is the known prevalence of PCOS in ATSI vs non ATSI women for the 18 - 24 vs 25-30
group, outside of your research data.  Anecdotally, from the  regional/ remote AMS I work
at for 30 years,  ATSI women start families much younger thus PCOS is often not an issue
however over time and increasing age there is GDM progressing to T2D increasingly recorded.
The average parity range is 5 -10 between 18 - 48 years of age.    GDM and T2D seem to be a
greater obstetric issue than infertility for ATSI.  Infertility is usually seen in ATSI women who
delay starting a family due to work and career commitments as seen with non ATSI women.
PCOS has been seen in girls as young as 14 -16 yrs and there is knowledge in the community to
commence a family earlier than later.  Yes Metformin is the medication of choice with Ozempic/
Saxenda  often used for weight loss in the treatment of PCOS together with a contraceptive,
with the Ozempic/ Saxenda ceased prior to conception.
There is active conception planning in many AMS services.   I am unsure if this area has been
researched however your recommendation to collaborate with other clinical services (ACCHO,
AMS, RFDS) is appropriate.
Congratulations on a well written paper and  providing valuable research.
Title: Management of encounters related to subfertility and infertility in Australian general
practice: a focus on Aboriginal and Torres Strait Islander females
Version: 3 Date: 27 Jun 2023
Reviewer's report:
Thank you for the opportunity to review this well-written manuscript that adds to the existing
literature.  I have included some suggestions and queries to be addressed
Title:  This paper compares, includes and reports data on both Indigenous and non-Indigenous
groups. Whilst  there is a heavy focus on the Indigenous findings in the discussion, the title is
not truely  reflective of the content. To rectify this,  a title change is needed or the paper needs
re-framing. I suggest the former that could still include Aborignial and Torres Strait Islander
females ie Management of encounters of .... females inclusive of...
Abstract - results - please include the full names of the abbreviations
Introduction:
Second paragraph - chage people to peoples
References should be included in the third paragragh
The authors state that GPs play a central role in the diagnosis and management of infertility,
however no evidence is included  to support this claim. Evidence  is needed as it could be argued
the  role they play  is only referral
It is unclear as to why reference 6 has been used for referencing the dataset, when that particular
study used the BEACH dataset
Study population : please include how the inclusion of at least two encounters improved data
quality
Results - management of encounters - please include detail in relation to the abbreviations used
Discussion - edit required for poor health and 'more visit GPs more '
Title: Assessment of supportive care needs among cervical cancer patients under treatment  in
Nepal: a cross sectional study
Version: 0 Date: 30 Oct 2022
Reviewer:  Lila Bahadur Basnet
Reviewer's report:
- The background section should also cover the basic introduction to cervical cancer.
- The second paragraph begins with this sentence :
"Cervical cancer is in the first position among women and second position among both sexes
in Nepal."
This sentence needs to be reframed and make it more clear.
- The third paragraph of the background section mentions the symptoms and complications.
Again, it says about the role of supportive care and its benefits. Then, it talks about the effects
on health again. This does not seem to be coherent and needs re-writing.
- In the rationale section, researchers write :
"After conducting the search, 286 records were obtained. Out of them, 270 articles were not
related to supportive care needs, but 16 articles were related to supportive care needs.  Among 16
articles on supportive care needs, 5 were review articles that were not specific to Nepal, and 11
articles were conducted in other countries, namely in Indonesia, Netherlands, Denmark, Spain,
Australia, Northern Ireland, Amsterdam, Canada, Japan, and the USA.  Hence, the authors have
decided to assess the supportive care needs and their predictors among cervical cancer patients
in Nepal."
As this study is a cross-sectional study, the above search strategy and the Mesh terms shown
in the article do not add any value to the article. 'Extensive literature review' is mentioned in
the article later too.
If authors want to keep the above search strategy, they need to add a separate table showing the
major findings of such search.
The authors have used the terms convenient sampling (in the abstract) and purposive sampling
(in the body) interchangeably.
However, a convenience sample is one that is drawn from a source that is conveniently accessible
to the researcher. A purposive sample is one whose characteristics are defined for a purpose that
is relevant to the study. (Andrade et. al. Indian J Psychol Med. 2021)
- I would suggest revising the conclusion section to make it inferential to the findings.
- Overall, the article is a good effort in a much-needed area. Revision is needed to correct
grammatical errors too.
1. Andrade C. The Inconvenient Truth About Convenience and Purposive Samples. Indian J
Psychol Med. 2021 Jan;43(1):86-88. DOI: 10.1177/0253717620977000. Epub 2020 Dec 17.
PMID: 34349313; PMCID: PMC8295573.
Title: Assessment of supportive care needs among cervical cancer patients under treatment  in
Nepal: a cross sectional study
Version: 1 Date: 27 Jan 2023
Reviewer's report:
Comments for the manuscript entitled “”Assessment of supportive care needs among cervical
cancer patients under treatment  in Nepal: a cross sectional study”
Comment 1: Is there any specific reason to show burden in both number and percentage as you
have presented in 4th and 5th line of Background?  It would be more comparable if you could
write all the numbers (expressed for showing burden of disease) in percentage.
Comment 2:  You presented    “The incidence of CC in National Tertiary Cancer Hospital in
Nepal was relatively constant, 2012-2017…….”
Does this data represent single tertiary care or all the tertiary care? Please denote it.
Comment 3: What was the reason behind using convenient sampling?  As CC patients are
currently under medication and you would have easy access to sampling frame, so that you could
do probability sampling and overcome sampling bias.
Comment 4: Who have validated the Nepali version of SCNS-SF 34N? If you then, you
might have pretested it for calculating cronbach’s alpha coefficients, then where has conducted
pretesting elarify about it.
Title: Assessment of supportive care needs among cervical cancer patients under treatment  in
Nepal: a cross sectional study
Version: 3 Date: 29 Mar 2023
Reviewer's report:
My comment for this research paper is the same as I had previously done. I cannot be positive
about the paper if I have to comment on the same thing again and again without being applied.
Still, I think the research paper is too long. The introduction and discussion section need to be
more specific on cervical cancer studies.  The discussion section needs to be rewritten and not
repeated with the same information as it was presented in the introduction and result section. I
have made specific comments in the track change file of the final manuscript.
Previously I raised the issue of Multicollinearity but it was not addressed by
the author. Multicollinearity is a statistical concept where several independent
variables in a model are correlated. Collinearity is a relationship among independent
variables, the dependent variable doesn’t matter. We should check the issue of
Multicollinearity every time before we build the regression model. Please consult
your statistician. (https://www.statisticssolutions.com/free-resources/directory-of-statistical-
analyses/assumptions-of-logistic-regression/#:~:text=Third%2C%20logistic%20regression
%20requires%20there,highly%20correlated%20with%20each%20other)
Title: Successful surgical treatment of postmyomectomy uterine diverticulum: A case report
Version: 1 Date: 22 Dec 2022
Reviewer:  Antoine Naem
Reviewer's report:
General Impression:
The authors reported a very interesting case of uterine diverticulum following open-
myomectomy. The case is rare and the manuscript is very informative. It is well-written and well-
structured. The figures are clear and representative. The treatment followed a very reasonable
rationale. This case is certainly worth publishing but requires some minor revisions.
Comments:
1. In the case presentation of the abstract (line 15), it was mentioned that the fistula opens just
above the internal cervical os, so I could not understand how the fistula was entered on the
external cervical os.
2. In the case presentation section of the main text (line 15), please clarify what you mean by
“posterior ligament”. Is it the uterosacral ligament? Please use a precise anatomical term.
3. In the case presentation section of the main text (line 18), I could not understand which portion
of the fistula enters the external cervical os while it opens above the internal os. Please clarify
this point.
4. In the discussion section of the main text, please emphasize what added value hysteroscopy
brings to this treatment approach.
Title: Successful surgical treatment of postmyomectomy uterine diverticulum: A case report
Version: 5 Date: 08 Jun 2023
Reviewer:  Antoine Naem
Reviewer's report:
General Impression:
I have reviewed with great interest the revised version of the manuscript and I found a
significant improvement in the manuscript’s quality. I appreciate the authors efforts in improving
their work. I think the extra figure (figure 2) is of paramount importance to understand the
diverticulum localisation. However, I found some issues that should be also addressed before
finally recommending this manuscript for publication.
Comments:
1. In the case presentation section of the abstract (line 12), please write “behind it” instead of
“in front of it” to keep the anatomical description precise and standardised.
2. In the case presentation section of the abstract (line 14) and  the main text (line 10, page
7), I could not understand how would the fistula or the diverticulum enter the external cervical
os. According to the diagram, both the fistula and diverticulum are only related to the internal
cervical os. Please clarify the exact meaning of this phrase ”The portion entering the fistula on
the external cervical ostium side of the demarcated portion”.
3. In the case presentation section of the main text, please clarify whether the uterine cavity was
opened while dissecting the the cyst’s wall from the surrounding uterine tissue.
4. According the histopathological findings, endometrial tissue was observed. How likely this
diverticulum represents an adenomyoma that occurred  postoperatively? Do the authors suppose
that this tissue is eutopic endometrial tissue? Did the authors observe chocolate-like material
similar to the content of endometriosis while presenting the cyst’s wall? It is known that
adenomyosis could originate in uterine niches after Caesarean sections. This diagnosis is worth
consideration.
5. Minor language polishing is favoured to improve the quality of the text.