JerMa88/BMC_Womens_Health_Peer_Reviews huggingface dataset:
Title: Diagnostic and Therapeutic Hysteroscopy in Ethiopia: A Retrospective Study on Practice
and Outcomes
Version: 3 Date: 07 Oct 2024
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: In general, the study is good. The objective is well understood, the
methods are clear, the analysis and results' interpretation are well presented and consistent with
the objective and results obtained.
My main concern is that this study is just a descriptive one, and presents a part of the national
reality. It would be important that these results enphasize the safety of the procedure and that it
would become more available in the future, even in an ambulatory setting outside the operative
room, with no anesthesia.
This paper presents a national reality regarding a minimal invasive procedure in gynecology
- histeroscopy. Histeroscopy can be used either as diagnostic or therapeutic and is widely
used nowadays. Ethiopian use of histeroscopy is growing and they present their reality. The
conclusions are essentially descriptive but they state the security of hysteroscopy which should
encourage them to make it more widely available.
Title: Sleep disturbances and female infertility: a systematic review
Version: 1 Date: 27 May 2024
Reviewer's report:
Dear Authors
I appreciated the opportunity to review this manuscript which involves a relevant and current
topic.
The authors described the main important factors related to sleep effects in reproduction.
My comments and suggestions are in blue throughout the manuscript attached. Some minor
comments are related to English language. Some of them need to be reformulated  or splitted in
two. The authors used many et. al., and I think it is not scientific/formal writing.
The Results of the tables would be better understood if the authors used more symbols to
illustrate the findings, with a clearer visualization.
Standardize some terms, e.g sleep disorders or sleep disturbances. I suggest sleep disorders.
With these minor corrections, I believe the manuscript would be fit for publication in this journal.
Title: Sleep disturbances and female infertility: a systematic review
Version: 2 Date: 12 Jul 2024
Reviewer's report:
The manuscript "Sleep Disturbances and Female Infertility: A Systematic Review" presents a
thorough and well-structured analysis of the association between sleep disturbances and female
infertility. The authors have meticulously revised the manuscript to address the reviewers'
comments and suggestions.
The authors conducted an extensive search in PubMed and EMBASE, ensuring a broad and
inclusive review of relevant studies. The use of JBI Critical Appraisal tools to assess the quality
of included studies adds robustness to the review.
The review offers valuable insights into the impact of sleep disturbances on fertility treatment
outcomes and highlights potential mechanisms linking sleep disorders to infertility. The
authors have addressed the reviewer's suggestion to standardize terms, choosing to use "sleep
disturbances" consistently throughout the manuscript. Additionally, they focused exclusively on
obstructive sleep apnea (OSA) to ensure clarity and precision.
The manuscript provides a comprehensive discussion on potential mechanisms, including
circadian rhythms, hormonal dysregulation, oxidative stress, and immune response. The authors
have successfully addressed all the reviewers' comments, including restructuring the manuscript
according to journal guidelines, improving language and clarity, and providing a detailed point-
by-point response to each comment. The revisions have significantly enhanced the quality and
clarity of the manuscript.
Title: Impact of Menopausal Status on Cognitive Function in Female Papillary Thyroid
Carcinoma Patients: A Longitudinal Propensity Score Matched Study
Version: 0 Date: 24 Sep 2024
Reviewer:  Víctor Manuel Vargas-Hernández
Reviewer's report:
Severe decline in cognitive function characterizes dementia. Mild cognitive impairment
represents a transition between normal cognition and dementia. The frequency of cognitive
changes is higher in women than in men, cognitive complaints are more common around
menopause, a phase marked by a decrease in hormone levels, especially estrogen. The
tendency towards poorer cognitive performance in women during menopause. The transition
to menopause is important, as it is a period of intense hormonal changes and symptomatic
stress, which may be related to cognitive decline. Estrogen may play an essential role as a
neuroprotective agent,
The incidence of differentiated thyroid cancer increases in the population over 55 years of age.
Thyroid cancer and its treatment are associated with worse outcomes in postmenopausal women
than in the younger population. Hormonal changes: Menopause involves significant hormonal
changes, particularly a decrease in estrogen levels, which can affect cognitive functions such as
memory, attention, and processing speed. These changes may be more pronounced in women
undergoing cancer treatments that can further disrupt hormonal balance.
Title: Impact of Menopausal Status on Cognitive Function in Female Papillary Thyroid
Carcinoma Patients: A Longitudinal Propensity Score Matched Study
Version: 1 Date: 27 Nov 2024
Reviewer's report:
Review Comments to the Author:
The authors tried to investigate the “Impact of Menopausal Status on Cognitive Function in
Female Papillary Thyroid Carcinoma Patients”. The authors tried to add the novel information to
the literature by performing this study. The study design, materials and methods, and the statics
used are appropriate however there are some comments to be addressed, which are noted below.
Major comments:
1. How did the author decide that the only female papillary thyroid carcinoma patients are
impacting on cognitive function by menopausal status?
2. As per the literature in the introduction section, cognitive impairments may occur in cancers
and non-cancer conditions then why PTC patients were chosen to investigate the relationship
in these patients?
3. Please explain how the author evaluated the history of strokes, seizures, anxiety, or depression
in exclusion criteria.
4. After 3 and 6 months, the number of patients does not follow the equal sample size as 1:1 in
each group of premenopausal and postmenopausal groups then how did you address the missing
data? Please explain.
5. As per the results of study, there is significant difference of mean / range ages between the pre
and postmenopausal groups. Please explain the age factor will not affect the study hypothesis
that is the assessment of MoCA between groups.
6. Explain the how did the confounding factors were addressed?
7. What are the guidelines which have been proposed for the clinician to educate the
postmenopausal patients belong to rural residents.
8. Prospects may be mentioned to provide the insights to investigate the underline mechanisms
at molecular levels.
9. It is very important to discuss the results of the current study in agreement or disagreement
with other studies.
Minor comments:
1. Mention the unit time with age parameter such “Given these criteria,this study specifically
targets women over 40” and check it throughout the manuscript where applicable.
2. There are some grammatical/abbreviation errors, and they should be revised throughout the
manuscript where appropriate.
3. Write scientific and compound sentences with proper conjunctions throughout the manuscript
where appropriate.
Title: The effect of aerobic exercise on sleep disorder in menopausal women: A systematic
review and meta-analyses
Version: 0 Date: 13 Mar 2024
Reviewer's report:
Thisis a vey nice and needed rerview of 19 carefully selectedstudies/publications on the effect of
exercise intervention on sleep quality in postmenopausal women. There are jus a few comments I
want to make. Introduction: HT is NOT a risk factor for cervical cancer (V Vargiu et al: Hormone
replacement therapy and cervical cancer: a systematic review of the literature. Climacteric
2021;24:120-127 PMID: 33236658DOI: 10.1080/13697137.2020.1826426). 3rd parag/line 3 :
number 1 is missing.
Limitations: discuss the effect of possible (and likely) dilution of exercise program to the control
group. It is very difficult to avoid within a community.  The control group should be from a far
away location.  However, in this case, the dilution would probably only weaken the difference
between the groups and the result.
Title: The effect of aerobic exercise on sleep disorder in menopausal women: A systematic
review and meta-analyses
Version: 5 Date: 17 Sep 2024
Reviewer's report:
Thank you for the opportunity to review this well-written manuscript. The manuscript needs
some revisions.
Please check the whole of the manuscript for some errors such as; “ and We used Review
Manager 5.3 and Stata 16.0……”
Writing reference numbers in the text needs revision : “disease, and other diseases [4],[5],[6],
[7],[8]”  should be” ……. [4-8]”   ) Please check the whole of the manuscript(
And also for errors such as “training factors, as follows) :1)whether the intervention…..”
In figure 1, the “(n=645)” is duplicate.
All abbreviations used in the manuscript should be redefined the first time they are mentioned
in the text. (PSQI, ISI ,  KMI, ..)
“…… aerobic exercise in intervening for sleep disorders in menopausal  girls, 3D side-by-
side”  ??
Title: The effect of aerobic exercise on sleep disorder in menopausal women: A systematic
review and meta-analyses
Version: 8 Date: 06 Nov 2024
Reviewer's report:
Thank you to the authors for making all the necessary changes in response to the comments
received. I recommend reviewing the English and correcting a few misspelled words (e.g., in
the methods section: "following," "strategy," "content").
Title: P53 marker expression in epithelial ovarian tumours in a centre in Nigeria – A descriptive
study
Version: 1 Date: 24 Oct 2024
Reviewer:  Tarek Tawfik Amin
Reviewer's report:
BMC Women’s Health
Title: P53 marker expression in epithelial ovarian tumours in a centre in Nigeria – A descriptive
study
Comments to the authors:
General comments;
- Questionable novelty
https://ccij-online.org/storage/files/article/ccij-k12bdkji6p8-749/
ClinCancerInvestigJ_2018_7_4_143_248464.pdf
https://ccij-online.org/article/profile-of-p53-expression-in-epithelial-ovarian-carcinomas:-a-
multicenter-study-from-south-east-nigeria-749
https://pubmed.ncbi.nlm.nih.gov/32317522/
the authors should as a highest priority to emphasis the novel aspect of their study???
- External validity threat: very small sample size included??
Specific comments;
- The title as well the abstract did not tell what P53 (tumor suppressor gene???).
- The tile entailed “in a centre in Nigeria” “a single center study from Nigeria”
- “However, there is a dearth of knowledge on p53 expression in these tumors in African women”
this not true, please review the relevant literature in this context??
- “Our study aimed to determine the pattern of p53 expression in various types of epithelial
ovarian tumours.” Is it pattern or patterns??
- What is wild type expression?
- Why benign ovarian tumours were included??
Introduction:
- “p53 is a tumor suppressor gene located on chromosome 17p13 that encodes a 53 kDa protein.
It is often referred to as the 'guardian of the genome' because it ensures that cells repair damaged
DNA before proceeding with cell division: please mention the reference????
- What was the rationale for conducing this study??? I did not see why the investigators
conducted this research, no added value to the already existing corps of the literature??
Material and methods:
- Why only case retrieval took place between 2005 to 2014?
- How such records were stored, managed, and retrieved?
- If there was a database, what kind of variables were included???
- Completeness, accuracy and other conditions governing the data validation of the retrieved
records?? Please mention all these points while describe the methods section.
- For the tissue preparation section, reference must be inserted for each step mentioned???
- The merits and demerits of the different scoring systems (and grading) should also be stated???
- Number and qualifications of the slides reviewers (% agreement, and interrater statistics).
- Intensity of staining; describe the figures in the table and numerate this table as table 1.
- What statistical test including correlation were used in this study???
- Chi-square test is not valid as some cells included less than 5 observations?? And it should
be very cautiously interpreted.
Results;
- Table 1; can summarized in “stacked bar chart” with proper footnote as many zeros will confuse
the readers and will not be informative??
- Same for table 2 and 3, can be converted into graphs.
Title: P53 marker expression in epithelial ovarian tumours in a centre in Nigeria – A descriptive
study
Version: 1 Date: 24 Oct 2024
Reviewer's report:
Thank you very much for your study. You conducted a retrospective research of epithelial
ovarian tumours immunohistochemical analysis using p53 antibodies. Many  studies have
reported that survival is poorer in patients with p53 overexpression.However your Counclusion
first centence is not clear:The majority of epithelial ovarian carcinomas in our hospital are
high grade, with many serous carcinomas showing either p53 overexpression or loss of
expression.Boh over expression and loss of expression is the same meaning? You should add
clearer conclusion message please..
Except  this,it was well written  paper.
Thanks...
Title: P53 marker expression in epithelial ovarian tumours in a centre in Nigeria – A descriptive
study
Version: 1 Date: 28 Oct 2024
Reviewer's report:
Introduction :
The introduction effectively presents the fundamental role of p53 as a tumor suppressor gene
and its function in DNA damage response and cell cycle regulation.
- While the general role of p53 is well-established, it would be beneficial to provide more specific
information regarding its involvement in ovarian cancer. Are there any known mutations or
alterations in p53 that are associated with ovarian cancer?
- Additionally, discussing the potential prognostic significance of p53 expression in ovarian
cancer would strengthen the introduction.
Method :
-While the 10-year study period suggests a potentially large sample size, it would be beneficial
to specify the exact number of cases included in the final analysis.
- It would be helpful to describe the criteria used to assess the quality of the retrieved FFPE
tissue blocks.
-While the discussion focuses on the correlation between p53 expression and tumor behavior,
a more in-depth exploration of the underlying molecular mechanisms would enhance the
understanding of the biological significance of these findings.
-The discussion could be strengthened by outlining potential future directions for research.
For example, the authors could suggest investigating the role of p53 in other molecular subtypes
of EOTs or exploring the potential of targeted therapies that exploit p53-related vulnerabilities.
Title: P53 marker expression in epithelial ovarian tumours in a centre in Nigeria – A descriptive
study
Version: 2 Date: 10 Nov 2024
Reviewer:  Yuquan Chen
Reviewer's report:
The manuscript titled "P53 marker expression in epithelial ovarian tumours in a centre in Nigeria
– A descriptive study" addresses an important gap in the literature by examining the patterns of
p53 expression in epithelial ovarian tumors (EOTs) from a region with limited prior research.
The topic is clinically relevant, and the methodology for immunohistochemical analysis is well-
structured. However, several significant issues must be addressed before the manuscript is
suitable for publication. The study lacks sufficient integration of its findings with regional and
global research, as it does not compare the results to studies from other low-resource settings or
sub-Saharan Africa, which would strengthen its relevance. The statistical methods, particularly
the use of a chi-square test, are inadequately justified, and alternative analyses, such as logistic
regression, are not considered, which limits the robustness of the statistical interpretations.
Figures referenced in the manuscript are poorly described, especially Figure 3, where a clearer
explanation of the visualized data is necessary to aid understanding. A major limitation is the
absence of tumor staging information, which is critical for interpreting the clinical implications
of p53 expression. Without this data, the results lack depth, and this limitation is not adequately
discussed.
Furthermore, the methodology section does not address potential challenges or limitations in the
immunohistochemical process, such as variability in antigen retrieval or antibody specificity,
which could affect result reliability. The discussion often overgeneralizes findings, such as
claiming that p53 mutations are hallmarks of aggressive ovarian phenotypes, without adequately
connecting these statements to the specific study results or providing appropriate citations.
The interpretation of p53 expression categories—negative, wild-type, and overexpression—
is not sufficiently explored, particularly concerning the clinical implications of wild-type
expression in low-grade tumors, leaving a critical gap in understanding the study's findings.
Ethical considerations are also insufficiently addressed; while ethical approval is mentioned,
the manuscript does not clarify whether informed consent was waived or obtained for the
use of archival tissues, which raises concerns about compliance with ethical standards. These
substantial issues need to be thoroughly addressed through a major revision to improve the
manuscript's scientific rigor, contextual relevance, and transparency.
Title: P53 marker expression in epithelial ovarian tumours in a centre in Nigeria – A descriptive
study
Version: 2 Date: 11 Nov 2024
Reviewer:  Tarek Tawfik Amin
Reviewer's report:
The comments to the authors were partially fulfilled;
- There is no need to justify the small sample size based on the availability of cases recorded
in your data bases.
- Consider the wider readers community and not just only those concerned "P53" should be
mentioned in the title?
- Background of the graphs should be manged and more clear.
- The size of the bars used should be proportionally adequate and not this wide?
- Chi-square using the Fisher exact should be mentioned to adjust the resultant statistics.
-  There are other studies from Nigeria that addressed the same topic, please mention.
- start your discussion with answering your research question.
Title: P53 marker expression in epithelial ovarian tumours in a centre in Nigeria – A descriptive
study
Version: 2 Date: 15 Nov 2024
Reviewer's report:
Thank you for giving me the opportunity to review this interesting study "P53 marker expression
in epithelial ovarian tumours in a centre in Nigeria".
However, I have some comments and recommendations:
Comments:
Title: - Is appropriate for the content of the article.
Abstract:- Represents a suitable summary of the work.
Article content:- The methods and results have been well explained.
Conclusions:- Are justified on the basis of the study.
Recommendations:
Discussion:- Mention the strength of the study.
References:- Stick to the format of the journal.
General:- Revise language, grammar and syntax.
Title: The impact of a lifestyle promotion program on anthropometric and clinical
manifestations in adolescents with polycystic ovarian syndrome: a randomized controlled trial
Running title: Lifestyle promotion program in adolescents with polycystic ovarian syndrome
Version: 1 Date: 08 Mar 2024
Reviewer's report:
Title: “The impact of a lifestyle promotion program on anthropometric and clinical
manifestations in adolescents with polycystic ovarian syndrome: a randomized controlled trialv”
Comments and recommendations on the content of the manuscript:
Abstract
P.2, line: 64: eliminate spelling errors such as “Poly Cystic”
Methods section
P.5, lines 132-137 Participants
There is no information about the number of participants
Please add in this section, more basic information about the groups such as BMI, ethnicity/race.
P.5, lines 138-147
There is no ref. related to Rotterdam criteria
P.5, lines 160-175 Intervention
The content of the intervention is too general. What is the difference between the study group
and the control group in this respect.
Each session should be pointed out, named, and more precisely described, both before Covid and
during Covid-19 pandemic. In particular, the Authors should describe the dietary and physical
activity intervention as well as the content of each session, because this is the clue of the lifestyle
intervention.
Discussion and Conclusion section
At the beginning of the Discussion section the aim of the study should be mentioned.
The strength and limitation section should be added and separated as a subsection from the
Discussion section.
Title: The impact of a lifestyle promotion program on anthropometric and clinical
manifestations in adolescents with polycystic ovarian syndrome: a randomized controlled trial
Running title: Lifestyle promotion program in adolescents with polycystic ovarian syndrome
Version: 4 Date: 11 Apr 2024
Reviewer's report:
The work has been corrected in accordance with the previous comments. I have no further
comments. Congratulations to the Authors