Reviewer’ s report
Title: Effects of vaginal administration of conjugated estrogens tablet on sexual function in
postmenopausal women with sexual dysfunction: a double-blind, randomized, placebo-controlledtrial
Version: 0Date: 13 Apr 2020
Reviewer: M. Acien
Reviewer's report:
Dear authors,
Please notice that there are lots of abbreviations that make the reading difficult, some of them evenunnecessary (f.e. CW, PU, AG…). Also along the text some abbreviations are mentioned, then notused and then mentioned again at the Discussion section. Finally, some of them are missing atabbreviation's list.An inclusion criteria was one vaginal atrophy symptom in moderate intensity, please describeaccordingly (symptoms and measurement range).I agree with the use of the Thai version of the Female Sexual Function Index questionnaire, butmany publications have proven that the (ab)normality score changes with age. Here you havetaken as normal a score > 26. 55 points but the age range of patients included in the study is verywide (45-70y).The result is a study with 58 participants and missing data completing the protocol but statisticalsignificance needed 30 patients per study branch. Additionally numbers reported in the resultssection are not accorded with those in Figure 1 Protocol flow diagram and neither with Table 5.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
YesDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?
If an additional statistical review is recommended, please specify what aspects require further
assessment in your comments to the editors.
I recommend additional statistical reviewQuality of written English
Please indicate the quality of language in the manuscript:
Acceptable
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