Reviewer’s report
Title: 
Use of trastuzumab in treating breast cancer during pregnancy: a
systematic review and meta-analysis
Version: 
1 
Date: 
22 Dec 2020
Reviewer's report:
Thank you for the opportunity to review this manuscript, I have no COI to
disclose. 
This is a revised version of a SR and MA on the use of trastuzumab for patients
with breast cancer during pregnancy. The study is well written and interesting,
and more importantly, this tackles a relevant topic that is not focused on
extensively in previous literature. The authors' revised manuscript reads well and
would be suitable for publication. The study would be interesting to the readers
of BMC Women's Health. 
I only have one comment. I suggest that the authors specify more clearly in their
methodology (and maybe even introduction), what their main outcomes are.
Were there any outcomes that if absent led to study exclusion?
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes