Reviewer’ s report
Title: A Case Report of Multiple Symmetric Lipomatosis in an East Asian Female
Version: 1Date: 22 Jun 2020
Reviewer's report:
The authors present a case of MSL in a middle-aged Korean woman. The case is very typical and
it is well described. Maybe some more additional comment should be done on the fact that thepatients seems to have a distribution of lipomatous masses that it is more typical of male thanfemale gender (Busetto L et al. Differential clinical expression of multiple symmetric lipomatosisin men and women. Int J Obes Relat Metab Disord. 2003;27:1419-22).
Minor points.1) The standard term Multiple Symmetric Lipomatosis (MLS) should be preferentially used in the
title and in the text.2) Page 6, Line 133. "Alcohol overconsumption is identified as the main cause of this disease". Isuggest to change "an association between alcohol overconsumption and the disease has beenfrequently reported". Association does not imply a causal relationship.3) Page 8, Line 182. "Madelung's disease has no association with life expectancy". There is at leastone long-term follow-up study demonstrating a reduced life expectancy in patients with MLS(Enzi G et al. Multiple symmetric lipomatosis: clinical aspects and outcome in a longtermlongitudinal study. International Journal of Obesity 2002;26:253-261). In this report a highincidence of sudden death has been confirmed.
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Are the methods appropriate and well described?
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YesDoes the work include the necessary controls?
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No
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Not relevant to this manuscriptQuality of written English
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Acceptable
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