Title: Title: When Synchronous Mucinous Metaplasia and Neoplasia of the Female Genital
Tract and Peutz-Jeghers Syndrome Meet: A Case Report and Literature Reviews
Version: 1 Date: 30 Apr 2024
Reviewer's report:
I would like to express my gratitude for the opportunity to review the manuscript. After a
thorough reading of the article, I find the topic intriguing. However, there are several issues that
compel me to recommend major revisions of this manuscript.
ABSTRACT
One suggestion for improvement would be to provide more specific information about the
treatment received by the patient. Additionally, it would be helpful to include any significant
findings or implications from the literature reviews mentioned in the title.
INTRODUCTION
The depth of research and analysis presented in the Introduction is limited. The text briefly
mentions that SMMN-FGT and PJS are rare diseases with low incidence, and highlights the
potential for clinical misdiagnosis or missed diagnosis. However, there is no further exploration
or discussion of the topic. To improve the Introduction, the author could provide a more
comprehensive overview of the current understanding of SMMN-FGT and PJS, including their
clinical manifestations, diagnostic challenges, and treatment options. Additionally, the author
could highlight the significance of studying the co-occurrence of these two conditions and the
potential implications for patient management. This would provide a stronger foundation for the
case report and literature reviews that follow.
DISCUSSION
The authors mention that there are literature reviews on SMMN-FGT, but they do not provide
any specific information or findings from those reviews. Including relevant studies and their
findings would enhance the depth of research presented.
The authors briefly mention that SMMN-FGT is closely related to pyloric gland metaplasia
(PGM) and describe the morphological features of SMMN-FGT. However, they do not delve
into the underlying pathogenesis or molecular mechanisms involved in the development of
SMMN-FGT. Including this information would provide a deeper understanding of the disease.
The authors mention that surgical treatment is the initial approach for SMMN-FGT, but they
do not discuss other treatment options or their outcomes. Including information on adjuvant
therapies, such as radiotherapy and chemotherapy, and their effectiveness in treating SMMN-
FGT would be valuable.
The authors briefly mention that there are reports of cases where postoperative follow-up without
adjuvant therapy was conducted for benign lesions. However, they do not discuss the long-
term prognosis of SMMN-FGT or the need for regular surveillance. Including information on
prognosis and long-term follow-up recommendations would be beneficial.
The author only briefly mentions the prognosis of SMMN-FGT and does not provide any
specific data or statistics. It would be beneficial to include more detailed information on the
prognosis and outcomes of this condition.
Additionally, the author mentions the importance of early detection and regular monitoring
for high-risk PJS patients, but does not provide any specific recommendations or guidelines
for screening and monitoring. It would be helpful to include more specific information on
recommended screening protocols and frequency of monitoring for PJS patients.
Furthermore, the author briefly mentions patient education and genetic counseling, but does not
elaborate on these topics. It would be valuable to provide more information on the importance
of patient education, genetic counseling services available, and the potential benefits of early
screening and predictive diagnosis for family members.
CONCLUSIONS
To improve the conclusion, it would be beneficial to include a summary of the key findings
from the case report and literature reviews. This could involve discussing any common genetic
mutations or pathways that may be involved in the development of both SMMN-FGT and
PJS. Additionally, the conclusion could provide more specific recommendations for medical
professionals, such as guidelines for regular check-ups and screenings for patients with PJS and
their relatives.
GENERAL COMMENTS
The English grammar and expression do not meet the standards expected of a high-quality
international journal. The authors should seek assistance from an expert in this field.