Reviewer ’s report  
 
Title: Fecundity disorders in older women: declines in follicular development and endometrial  
receptivity  
 
Version: 0 Date: 05 Feb 2020  
 
Reviewer: Senem Arda Düz  
 
Reviewer's report:  
 
Dear Author;  
 
I reviewed the manuscript and I have some recommendations:  
 
What is the scientific proof of timed intercourse schedule according to unknown ovulation 
timing? Is there any confirmation method for implantation? What is the prediction method of 
ovulation?  
 
Is the re a scientific proof to confirm ovulation with ultrasoundographic assessement?  
 
In table 1 for both groups the mean and median values of participants' age is not existing.  
 
p values of statistic evaluation should be extracted from the abstract section.  
 
The story of infertility and/or ART treatment should be indicated in the main text.  
 
Table 3 is not existing in system however the results of table 3 are implicated in the text.  
 
There is no data of normal disturbance of all datas. It should be given in the text . 
 
The name of control group should be changed as 'young group'.  
 
In figure 3 the predictive value of endometrial receptivity is given for only older women. 
However it should be given for every group and total patient group.  
 
There is a contradiction about th e day in which sonography performed for material method 
section and result section.  
 
What is the concern of LUFS about the article? It should be described in more detail or it should 
be extracted.What is the method for calculation of VI, FI, VFI, it should be described.  
 
Discussion section should be written again because the discussion section is complicated and 
needs to compare the other researc results such as spontaneous cycles and also references of 
timed intercourse articles should be added.  
In clinical trials in which donation cycles recruited there is a contradiction of this manuscript 
results. It should be added that the trials which resembles to this trial should be added and 
discussed.  
 
There is no proof to say older women presents decreased follicula r development and endometrial 
receptivity, according to this manuscripts data. This phrase should not be written in conclusion 
section.  
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
No 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
No 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects requ ire further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either  now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents re lating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing intere sts? 
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare tha t I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I up load will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal