Reviewer’s report
Title: 
Necessity for subsequent surgery in women of child-bearing age with
positive margins after conization
Version: 
0 
Date: 
15 Mar 2021
Reviewer's report:
I read with great interest the manuscript, which falls within the aim of this
Journal. In my honest opinion, the topic is interesting enough to attract the
readers' attention. Nevertheless, authors should clarify some points and improve
the discussion, as suggested below.
Authors should consider the following recommendations:
- Manuscript should be further revised in order to correct some typos and
improve style.
- To date, several lines of evidence support the possibility to use specific
biomarkers to identify early stage cervical cancer and, in this way, offer a better
prognosis to the patients. This point deserves to be discussed, referring to:
PMID: 28918603; PMID: 28466456.
- I would recommend to stress novel pieces of evidence about high-risk HPV-
negative high-grade cervical dysplasia, which seems to have more favorable
outcomes than patients with documented high-risk-HPV infection (PMID:
33514481) as well the potential role of pre-operative conization before radical
hysterectomy for early-stage cervical cancer (PMID: 32320800).
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes