Reviewer’ s report
Title: Efficacy and cardiovascular safety of the new estrogen-free contraceptive pill containing 4
mg drospirenone alone in a 24/4 regime.
Version: 1Date: 15 Jul 2020
Reviewer's report:
The Manuscript titled "Cardiovascular safety of the new estrogen-free contraceptive pill
containing 4 mg drospirenone alone in a 24/4 regime" (number BMWH-D-20-00490R1) isscientifically interesting and well done. However, there are major concerns that severely affect thework.
In my concern:
-The study is interesting from the point of view of hormonal contraception, because a new POP,with only drospirenone, could be useful towards a lot of women giving them an alternative to theonly desogestrel POP. However, the problems of this paper are that the benefits about thecardiovascular system and the coagulation are too much highlighted, stressing too much thedangerousness of the oral contraception.-The authors should specify the period of assumption of the contraceptive pill and after how muchtime the exams were repeated.-The authors should edit the article in a more clear way, by specifying the data and the cyclecharacteristic (spotting, amenorrhea, menstrual bleeding,…).-The title should be modified, in that the "cardiovascular safety" is a secondary effect, the focusshould be the primary effect: the contraception safety.-In the Abstract, in Method section, the authors should delete "reducing cardiovascular risks", it is
misleading.
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No
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
NoDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
NoAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
Not relevant to this manuscriptQuality of written English
Please indicate the quality of language in the manuscript:
Acceptable
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