Reviewer ’s report  
 
Title: Pathological profiles and clinical management challenges of breast cancer emerging in 
young women in Indonesia: a hospital -based study  
 
Version: 0 Date: 23 Sep 2018  
 
Reviewer: Assaad Kesrouani  
 
Reviewer's report:  
 
The subject is of interest and could shed light over  breast cancer epidemiology.  
There is however some flaws in the methodology. Selection bias is not appropriately addressed 
by the authors. A tertiary center usually gets the ' bad' and younger patients; could this be the 
case in Indonesia? Is there any cor relation with the country' statistics regarding this question? 
How many patients were referred  and how much were followed by the center.  
More answers are needed before accepting this paper  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
No 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
No 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
No 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I recommend additional statistical review  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, o r salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to al l of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no conflict of interest  
 
I agree to the open peer review policy of the journal. I understand that my na me will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
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which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will n ot be published.  
 
I agree to the open peer review policy of the journal