Reviewer’s report
Title:  Effects  of  Aerobic  and  Resistance  Exercises  on  Circulating  Apelin-12  and  Apelin-36
Concentrations in Obese Middle-Aged Women: A Randomized Controlled Trial
Version: 0 Date: 18 Nov 2018
Reviewer: Zuzanna Goluch
Reviewer's report:
Comments:
TITLE: correct, corresponds to the work content.
ABSTRACTS: correct.
KEYWORDS: correct.
BACKGROUND: 
*line 76 diabetes type 1 or 2?
*line 97 explain abbreviation ACSM.  
*line 102 explain abbreviation HR max.
*line 103 explain abbreviation 1 RM .
OBJECTIVES: they were properly established and were fulfilled. 
MATERIALS AND METHODS 
*Materials as well as statistical methods applied are described correctly.
*The authors did not explain in what conditions the anthropometric measurements, necessary for
body composition estimates with the use of bioelectrical impedance analysis (BIA), were made.
*Were anthropometric measurements and body composition estimates were done in the morning?
*There was no information given in what places were the measures of waist circumference
taken? Was it half distance between the inferior margin of costal arch and upper crest of iliac
bone or was it another.
*There was no information given as to which reference values (literary source) was the source of
classifying the measurements of waist circumference and BMI. 
*Were  the  patients  prepared  for  measurements  (on  an  empty  stomach,  after  urination  and
defecation)?  Did  they  do  any  stretching  exercises?  Were  they  administered  any  diuretic
medicine or/and liquids including caffeine 24 hours before the body composition estimates?
This information has to be included so that the reader does not doubt the reliability of the
performed measurements and the results of the body composition estimates. 
*Moreover,  please  add  information  that  the  body  composition  estimate  with  bioelectrical
impedance analysis (BIA) was made on Inbody720apparatus in a tetrapolar setting. 
RESULTS 
*Properly and readablyn written.
*Internationally accepted rules and the international system of units (SI) should be used in Table
4.
DISCUSSION: 
*Factual discussion, but the Authors should more broadly refer to the results (value) of other
researchers who have done similar experiments.
CONCLUSION:
*lines the 283- 309 are not specific conclusions but summary.  The only conclusions a reader
might find are suggested in the abstract. 
REFERENCES:
*93.6% of literature comes from the last decade.
*According to publisher's requirements identifier DOI should be given in the reference list.
TABLES: 
*Are readable and well marked.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
No
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an additional
statistical review?
If  an  additional  statistical  review  is  recommended,  please  specify  what  aspects  require  further
assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Acceptable
Declaration of competing interests
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3. Do  you  hold  or are  you  currently applying  for  any patents  relating  to  the  content  of  the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds or
has applied for patents relating to the content of the manuscript?
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