Reviewer ’s report  
 
Title: Increased LDH5/LDH1 ratio in preoperative di agnosis of uterine sarcoma with 
inconclusive MRI and LDH total activity but suggestive CT s can: a case report  
 
Version: 0 Date: 22 Mar 2018  
 
Reviewer: Michele Peiretti  
 
Reviewer's report:  
 
The authors described a case report of a woman diagnosed with uterine leiomyosarcoma. 
Although preoperative diagnostic management in uterine mass is very controversial and with so 
many limitations, the authors have analyzed an interesting preoperative approach with the 
evaluation of LDH and imaging.  
 
 
The paper is well written.  
 
Further prospective studies are definitely encouraged to evaluate the  accuracy of the diagnostic 
method.  
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, plea se specify which controls are required in your comments to the authors.  
 
No 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscrip t or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written Eng lish 
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
 
 
Declaration of competing interests  
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1. Have you in the past five years received reimburseme nts, f ees, funding, or salary from an 
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3. Do you hold or are you currently applying for any patents  relating to the content of the 
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holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
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below. If your reply is yes to any, please give details below.  
 
nothing to declare  
 
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