Reviewer’s report  
 
Title: Factors associated with menstrual cycle irregularity and menopause  
 
Version: 0 Date: 01 Nov 2017  
 
Reviewer: Tizta Tilahun  
 
Reviewer's report:  
 
Abstract  
 
Method section, it is written as "We used a separate dat aset to analyze the risk factors of 
menstrual cycle irregularity and menopause (pre - and postmenopausal women: n=4788 and 13 
918, respectively)." Doesn't have the same connotation as 4788 samples were drawn from 13 
918.  
 
 
 
Method  
 
The secondhand smoking is w ell defined, but measuring the people's exposure to smoke at home 
or in their workplaces or in the different public places is very difficult.  
 
 
Measuring the level of stress from the response of respondents, which is not clinically proven. In 
that case, it  is perceived level of stress.  
 
 
 
Results  
 
Explain the logical interpretation of the result: "High educational level was found to have a 
statistically significant relationship with regular menstruation". Make the same explanations for 
other findings too.  
 
 
 
Figures and tables  
 
The last figure - does not have a title - add the title so that the reader can understand the take -
home easily.  
 
 
 
 
Are t he methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequat ely supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript : 
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the c ontent of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included 
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