Reviewer’ s report
Title: Reproductive capacity and recurrence of disease after surgery for moderate and severe
endometriosis –a retrospective single center analysis.
Version: 2Date: 08 May 2020
Reviewer's report:
Thank you for preparing this manuscript.
I would like to make the following comment:
The title of this paper is the 'Reproductive capacity and recurrence of disease after surgery formoderate and severe endometriosis' However, a lot more information were provided and may notbe relevant to this topic.
Firstly, I understand this study is with retrospective nature, however, we need to understand that
the inclusion period was over 11 years. In this 11 years, there will be very significant changes interm of diagnostic tools, operative personnel and skills. choices of postoperative treatment etc...and the questionnaires collected from the patients were also from different time interval from theindex surgery ( although the mean time was not mentioned in the paper) This will create a veryheterogeneous cohort of patients and made the analysis very difficulty.
Secondly, The discussion part is too long and some of them are out of focus. I would strongly
suggest authors to identify your intended discussion points. eg. What are the relevant of theintestinal surgery or stoma to reproductive potential and recurrence?
Thirdly, for the statistical test, we should not only compare the outcome by one single factors. eg.
the recurrence of endometriosis may be related to the surgical approach, but it will be also affectedby her age, her post-op treatment, or how long after the index surgery, all these are theconfounders that we have to consider and input in the statistical analysis. There are also too manytables and some are not relevant.
Thanks again for your effort in preparing this paper.Best regards,
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
YesDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Unable to assess
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
NoAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?
If an additional statistical review is recommended, please specify what aspects require further
assessment in your comments to the editors.
I am able to assess the statisticsQuality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being publishedDeclaration of competing interests
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