JerMa88/BMC_Womens_Health_Peer_Reviews huggingface dataset:
Title: Factors Associated with Premenstrual Symptoms: A Study among Graduate-Level
Students of the Institute of Science and Technology, Tribhuvan University
Version: 3 Date: 07 Jun 2025
Reviewer's report:
This manuscript investigates the prevalence and associated factors of premenstrual symptoms
among graduate-level female students at the Institute of Science and Technology, Tribhuvan
University. Through an institutional-based cross-sectional design, the authors collected
data with a self-administered questionnaire and assessed premenstrual symptoms using the
Premenstrual Symptoms Screening Tool (PSST). The analysis, employing multiple binary
logistic regression, found that stress, use of menstrual delaying medicine, dysmenorrhea, and
age at menarche significantly influence the likelihood of reporting premenstrual symptoms. The
study contributes new insight into the psychosocial and menstrual health of Nepali graduate
students and highlights the need for targeted interventions.
Comments:
Please specify the geographic locations (e.g., city, province) related to participant recruitment
and clarify contextual factors of Tribhuvan University that may influence generalizability.
Provide a clear description of how confidence intervals were calculated in your analysis.
Additionally, explain the interpretation of CIs within the context of your logistic regression
findings.
Expand the discussion to include the implications of your findings for public health, especially
regarding student support services, awareness programs, and potential policy actions in the
university setting.
Present more detailed information about the modeling and regression frameworks used,
including assumptions, variable selection criteria, and any model diagnostics performed.
The current rationale for the study is limited. Enhance the introduction with more recent
and relevant literature to justify the importance of investigating premenstrual symptoms and
associated factors among university students.
Ensure all numeric values throughout the manuscript (text, tables, figures) follow a consistent
decimal format—use either one decimal place (.0) or two (.00) consistently.
Some references used to support prevalence and contextual statements are outdated. Please
incorporate recent literature to ensure your study reflects the latest understanding and statistics.
Revise and expand the list of keywords to more accurately capture the scope of the research.
If age-standardization was performed, specify which standard population was used and how
standardization affected your prevalence estimates.
Avoid including non-significant findings unless a strong scientific rationale is provided. Where
these results are retained, clearly explain their relevance.
Provide recommendations for future studies. Suggest ways in which further research could
address identified limitations or explore additional factors influencing premenstrual symptoms.
Title: Factors Associated with Premenstrual Symptoms: A Study among Graduate-Level
Students of the Institute of Science and Technology, Tribhuvan University
Version: 3 Date: 08 Jun 2025
Reviewer's report:
1. page 13, with different font sizes
2. I think  someone with  experience in writing papers revise the paper. The three-line table is
in a mess and the title is not placed at the top
3. The introduction section describes the risk factors of premenstrual syndrome. So, what is the
significance of this study? Repeat others' research?
4. page 6. I don't know whether this scale is currently popular or self-designed. Generally
speaking, popular scales have higher reliability and are more worthy of use. If it is a self-designed
scale, internal consistency only needs to be done once. Furthermore, what is the interval between
the two evaluations? And the analysis of the data can be placed in the attached table
5. Although it is a cross-sectional study of the college, the overall study population is the students
of the college over many years, not just those of the past few years. Therefore, the calculation
of the sample size is necessary.
Title: Factors Associated with Premenstrual Symptoms: A Study among Graduate-Level
Students of the Institute of Science and Technology, Tribhuvan University
Version: 4 Date: 07 Jul 2025
Reviewer's report:
Dear Authors,
Following a thorough review of all the submitted documents, I have found that the manuscript
uploaded to the platform does not contain the revisions requested by the reviewers. I am not
certain whether this was an oversight on the part of the authors, but under these circumstances,
I am unable to proceed with my contribution to the article's review.
Title: Factors Associated with Premenstrual Symptoms: A Study among Graduate-Level
Students of the Institute of Science and Technology, Tribhuvan University
Version: 6 Date: 15 Jul 2025
Reviewer's report:
Thank you for your response and for making valuable modifications to the manuscript based
on my comments. The revised manuscript has largely addressed and resolved the issues raised
previously. However, it would benefit from a thorough formatting or editing.
Title: Analysis of the risk factors of chronic endometritis in infertile women
Version: 3 Date: 21 Sep 2024
Reviewer:  Yigit Çak#ro#lu
Reviewer's report:
General comments:
The manuscript proposes information about an important topic- risk factors for chronic
endometritis in infertile women. In this retrospective study, the authors have analysed the risk
factors of chronic endometritis.
Abstract:
The abstract accurately describes the short-summarized content of the article.
Key words are adequate in quality and number.
The sentence starting with “Whereas the possibility….” Should be revised.
Background:
Information about chronic endometritis, mechanism of endometritis in infertile women, and the
diagnostic modalities have been given in the background section. Aim has been defined in this
section.
Methods
Design of the study, selection criteria of the participants, diagnostic criteria, data collection, and
statistical analysis methods have been defined in this section.
- Would the authors please give more information about the etiologic factors related with
infertility (poor ovarian response?hydrosalpynx?)?
- What was the number of previous IVF trials among the groups?
- Were patients with recurrent implantation failure analyzed seperately?
Results
The result section contains findings and observations in regards of the analysis.
Discussion
The discussion section states the importance and significance of the findings.
References:
The references section contains appropriate and number of references.
Tables:
Tables are demonstrable and well-designed.
Title: Analysis of the risk factors of chronic endometritis in infertile women
Version: 3 Date: 07 Nov 2024
Reviewer:  Monica Gupta
Reviewer's report:
I would like to congratulate the authors for choosing an important upcoming topic.
The manuscript requires some modifications
1. English language editing and spelling check
2. Diagnostic criteria by hysteroscopy can be included in methods section
3. In results section the authors have found more number of deliveries have association with
CE but it is not clarified whether the deliveries were vaginal or by caesarean section. As in
discussion they have concluded that intrauterine surgeries theoretically can cause CE. This needs
clarification
4. The most recent article by Yan Gao et al in scientific reports in 2024 can be cited where they
have not found any association between caesarean section and CE.
5.
The manuscript has been highlighted changes needed are added in comment box
Title: Analysis of the risk factors of chronic endometritis in infertile women
Version: 3 Date: 27 Nov 2024
Reviewer:  Haitham Bahaa
Reviewer's report:
* the title includes that your work on the infertile women but in discussion I discovered that ,
the included patients were prepared for ET and on IVF procedure
* patients with previous pregnancy should be identified if they received IUDs before
* the diagnosis based on hystereoscopic biopsy  which is invasive manoeuvre and use of a course
of antibiotics as a preparatory step before ET appears to be more applicable
* if patients on IVF protocol, there was need to identify the  type of protocol and the effect of
GnRH on the endometrium especially the cytokines
Title: Analysis of the risk factors of chronic endometritis in infertile women
Version: 6 Date: 28 Dec 2024
Reviewer:  Yigit Çak#ro#lu
Reviewer's report:
I would like to thank the authors for the revision of the MS.
Would the authors please clarify:
"weak spermatozoa" (sperm with low motility?)
"malformed spermatozoa" (morphologically abnormal?)
"ovulation disorders" (PCOS?)
"ovarian hypogonadism" (POI?)
Title: Analysis of the risk factors of chronic endometritis in infertile women
Version: 6 Date: 02 Feb 2025
Reviewer:  Ettore Cicinelli
Reviewer's report:
The paper from Zhang and coworkers aimed to identify if there is a high-risk group for chronic
endometritis (CE) in infertile women. The study was a retrospective single-center cohort study
was conducted on 209 infertile women with CE and 843 women without that. The risk of
developing CE was found to be 1.8 times higher in multipara than in nullipara (OR = 1.794;95%
CI, 1.216–2.645; P = 0. 003), and 1.7 times higher in patients with more than 6 years of infertility
than in patients with less than 2 years of infertility (OR = 1. 733;95% CI, 1.040–2.887; P
= 0.035), and the patients in combination with sequelae of pelvic inflammatory disease and
endometrial hyperplasia have a 1.7 fold (OR = 1.702;95% CI, 1.214–2.387; P = 0.002) and 2.2
fold (OR = 2.165;95% CI, 1. 376–3.406; P = 0.001) increased likelihood of developing chronic
endometritis, correspondingly. The possibility of acquiring CE would increase by 1.6 times for
each increase in the number of deliveries (OR = 1.621;95% CI, 1.200–2.189; P = 0.002) and 1.1
times for every additional year of infertility (OR = 1.077;95% CI, 1.032–1.125; P = 0. 001). The
authors concluded that according to univariable and multivariable regression analysis, the risk
factors for CE in women were a history of pregnancy, infertility for more than 6 years, sequelae
of pelvic inflammatory diseases, and endometrial hyperplasia.
1. The authors did not report any vase of repeated miscarriage as well as of repeated failures at
IVF. Data in literature show that both groups are at high risk for chronic endometritis.
2. The authors should explain why they performed hysteroscopy in the luteal phase when it
should be performed in the follicular phase. Moreover data in literature show that endometrial
biopsies for CD138 counting should be performed in the follicular phase.
3. The authors under results and discussion should underline that in their experience 24.8% of
patients referring for infertility were diagnosed with chronic endometritis and this information
is relevant
4. Due to the fact the endometrial samplings were performed in the secretory phase the authors
should acknowledge that some false negative cases may exist.
5. Many typing mistakes should be corrected.
Title: Exploring the Multifaceted Correlates of Household Decision-Making Autonomy Among
Married Women in Cameroon
Version: 3 Date: 20 Mar 2024
Reviewer's report:
Major comment:
I acknowledge the fact that the authors limited their sample to married women aged 15-49 years
old. However, “missing values” and “don’t know” responses to some variables in the dataset can
introduce biases into the estimations, hence how these issues were handled must be specified.
F statistics are commonly used in the context of linear regression to assess the overall
significance of the regression model. However, they are not typically used in logistic regression
models. Instead, other goodness-of-fit statistics like the Likelihood Ratio Test, Akaike
Information Criterion (AIC), and Bayesian Information Criterion (BIC) are more appropriate
for logistic regression.
Authors must show clarity in reporting unadjusted and adjusted odds ratios using OR and aOR/
AOR respectively.
I recognize your attempt to address this. However, when testing for multicollinearity using
the Variance Inflation Factor (VIF), you assess multicollinearity for each predictor variable,
not individual categories within a categorical variable. Multicollinearity among the categories
within a single categorical variable is typically not directly assessed using VIF. I suggest that
you redo this to accurately assess for collinearity, and report the mean VIF in your study. Do
this by omitting the notation “i.” in the command.
The revision has substantially improved the manuscript. With consideration of the concerns as
mentioned earlier, the paper is deemed suitable for publication.
Title: Exploring the Multifaceted Correlates of Household Decision-Making Autonomy Among
Married Women in Cameroon
Version: 3 Date: 28 Mar 2024
Reviewer:  Charles Lwanga
Reviewer's report:
Dear Editor,
I reviewed the manuscript last year and sent the comments  on November 23, 2023. I wondering
why  i still get the massage requesting for the review!
Thank you,
Title: Exploring the Multifaceted Correlates of Household Decision-Making Autonomy Among
Married Women in Cameroon
Version: 4 Date: 04 Jun 2024
Reviewer's report:
Exploring the Multifaceted Correlates of Household Decision-Making Autonomy Among
Married Women in Cameroon
Thank you for the opportunity to review the revised manuscript.
Comments
The revision has remarkably improved the manuscript. The authors have addressed all my
concerns with no further comments. This paper makes significant contributions to knowledge
and is deemed suitable for publication.
Title: Toxic Epidermal Necrolysis Following Lamotrigine Replacement Therapy in a Woman
Planning Pregnancy: A Case Report and Literature Review
Version: 1 Date: 25 Jan 2025
Reviewer:  Phuc Nhon Nguyen
Reviewer's report:
The case is interesting. The toxicity of this drug should be reported.
-BMI, medical history, obstetric, gynecologic histories should be described.
-Risk factors for development of reaction on this case.
-How many cases have been reported in literature? The authors should make a review with key
findings on PubMed, Google Scholar, Scopus…
-The risk of lamotrigine in other population, in male? doi: 10.7759/cureus.45334. doi: 10.1345/
aph.1E192. PMID: 15353576.
-The group of antiepileptic medication should be added in introduction.
-The toxic group of drugs (A/B/C/D) should be mentioned.
-The dose of lamotrigine must be given. doi: 10.1177/2045125316656707.
-Histopathological examination/ histochemistry examination of skin lesion was explored?
-Which management of this woman in the future for pregnancy planning and epileptic treatment/
antiepileptic medication?
- Antibiotic therapy was used? Should allergic tests be applied.
- To date, reproductive assisted technology plays an important role in high-risk women. In this
patient, should preimplantation genetic test be concerned since the toxic capacity of drugs in a
long time. DOI: 10.5001/omj.2025.17; DOI: 10.18502/ijrm.v22i5.16442
-Multidisciplinary team management should be applied in this case. Point of view from
obstetrician, neurologist, dermatologist, and pharmacologist.
Title: Toxic Epidermal Necrolysis Following Lamotrigine Replacement Therapy in a Woman
Planning Pregnancy: A Case Report and Literature Review
Version: 1 Date: 28 Jan 2025
Reviewer:  Gowri Dorairajan
Reviewer's report:
The article describes toxic epidermal necrolysis.
The causal effect has not come out.
There is no mention of the starting dose of lamotrigine.
There is no mention as to when was the last seizures.
The paragraph on investigations has to be phrased properly to reflect increase in hs CRP and
other investigations.
The case report has not explored the other causes of the TEN and fever like investigations for
viral infection, blood culture. the type of allergen test is not detailed. How are the author sure
it is not pemphigus
Why was a skin biopsy not performed.
Was a gene allele test carried out?
The last paragraph on conclusion is not conclusion derived from the manuscript.
Title: Toxic Epidermal Necrolysis Following Lamotrigine Replacement Therapy in a Woman
Planning Pregnancy: A Case Report and Literature Review
Version: 1 Date: 05 Feb 2025
Reviewer's report:
Dear Editor,
Thank you for the opportunity to review the article titled “Toxic Epidermal Necrolysis Following
Lamotrigine Replacement Therapy in a Woman Planning Pregnancy: A Case Report and
Literature Review” for BMC Women's Health.
The topic is intriguing, and the case is highly relevant. However, I have several suggestions that
may enhance the clarity and comprehensiveness of the article:
1. The patient’s obstetric history should be included.
2. The dose and interval of oxcarbazepine and topiramate should be specified.
3. CT should be spelled out upon its first mention.
4. The type, dose, interval, and route of administration of antihistamines should be provided.
5. The specific type of topical corticosteroids used should be mentioned.
6. The type, dose, interval, and route of administration of anti-inflammatory and anti-infective
therapies should be included.
7. The type of traditional Chinese medicine used should be identified.
8. The introduction and discussion contain redundant information. The first paragraph of the
discussion largely repeats details already provided in the introduction and should be revised to
avoid duplication.
9. The term “VIALEL” appears incorrect; it should be corrected to “Viale”.
10. EEG should be spelled out upon first mention.
11. The authors should expand on the management of SJS/TEN, discussing how their treatment
approach aligns with or diverges from previous studies.
Title: Toxic Epidermal Necrolysis Following Lamotrigine Replacement Therapy in a Woman
Planning Pregnancy: A Case Report and Literature Review
Version: 2 Date: 21 Mar 2025
Reviewer:  Gowri Dorairajan
Reviewer's report:
The authors have clarified all the comments of the reviewers. The corrections appear satisfactory.
In Page no.3, line  "Laboratory findings highlighted decreased counts of white and red blood cells
(WBC, RBC), platelet counts (PLT) , haemoglobin (HGB), lymphocyte percentage (LY%), high
sensitive C-Reactive Protein (hs-CRP), neutrophil ratio (NEUT%), and biochemical markers
such as aspartate aminotransferase (AST), beta 2 Microglobulin (#2M), lactic dehydrogenase
(LAD), alongside reduced total protein (TP), albumin (ALB), and electrolyte and coagulation
anomalies (Table 1). "
the authors should insert "increased" before high sensitive C- reactive protein....
Title: Beyond Anemia: A Comprehensive Analysis of Iron Deficiency Symptoms in Women
and Their Correlation with Biomarkers
Version: 1 Date: 27 May 2025
Reviewer's report:
Muhammet Özbilen and Yasemin Kaya report about 239 women who presented to their iron
deficieny clinic and were retrospectively analyzed correlating a plethora of symptoms with iron
deficiency biomarkers in order to characterize iron deficient anemic and non anemic patients.
The manuscript is well written (altbough a bit too long in my opinion) and the results are reported
in a comprehensible way. I have a few comments but all in all think the paper is worth publishing
1.  first of all I wonder why the patient groups stem from between March 2021 and August 2022,
which is about three years ago
2. as the intention of the paper is to raise awareness about symptoms especially in non anemic
iron deficient patients I wonder why and how patients present to their specialized outpatient
clinic? are these all referrals? have patients been treated for iron deficieny or are "unspecific
symtpoms" the reason patients present themselves to the clinic?
3. The language reads a bit "stilted" within certain parts, and there are minor flaws (e.g. page 5
lines 146/147) as well as expressions such as "tiredness quickly" which should be revised
4. page 7 lines 187/88 - this should be moved to the methods section
5. the range of symptoms presented is quite extensive - the paper would even be more interesting
if the authors could add a non-iron deficient cohort in order to compare the frequency of
symptoms to a "standardized" norm
6. the section about the median values of TSAT and the presence an absence of symptoms does
not add any clinically/scientifically relevant information (pages 9-10, lines 229 - 247) and can
be deleted in my opinion
7. the discussion should be streamlined as the main finding is - as pointed out correctly by the
authors - the fact, that non-anemic women present with the same plethora of symptoms as anemic
pts. As the authors main goal is to rise awareness I would suggest to add a few sentences to a
relevant clinical approach, e.g. which parameters should be determined at what timepoint when
women present to their GP or other specialists.
8. finally it would be great to see, how the pts. were treated and if the symptoms vanished or
decreased in frequency/Intensity. This might be beyond the scope of the manuscript but could
be a valuable addition for a potential sequel
Title: Beyond Anemia: A Comprehensive Analysis of Iron Deficiency Symptoms in Women
and Their Correlation with Biomarkers
Version: 1 Date: 06 Jun 2025
Reviewer:  Afagh Hassanzadeh Rad
Reviewer's report:
Dear editor in chief,
I appreciate your invitation.
I read this article and ave the following comments:
Please mention your keywords based on MESH.
Please address the variables in the methods section. It really needs a comprehensive description
on your data gathering.
Please add the correlation tests you have  used in the methods section.
How did you divided  patients into two groups: NAID and IDA? Add a reference and rite about
it in the methods section.
You have used Mann-Whitney U test in the Table, but you did not mention it in the statistical
analysis.
On the other hand, you have used T-test but you did not present mean and standard deviation.
Please mention you have assessed the normality distribution of quantitative variables.
Please revise the statistical analysis section, write about frequency, percent, median, interquartile
range, mean and standard deviation.
You have to report them based on their normal  or abnormal distribution in the tables and text.