JerMa88/BMC_Womens_Health_Peer_Reviews huggingface dataset:
Title: Impact of the number of cycles of platinum-based chemotherapy for early stage  ovarian
clear cell carcinoma on survival: a retrospective study
Version: 1 Date: 24 Feb 2023
Reviewer:  Yoshiki Ikeda
Reviewer's report:
The author used a cohort of 102 patients with stage I-IIA pure ovarian clear cell carcinoma
(OCCC) in his institution to demonstrate the impact of the number of cycles of platinum-based
chemotherapy on survival. He concluded that the recurrence and survival outcomes for 1-3
chemotherapy cycles were similar to that for at least four cycles as an adjuvant chemotherapy for
early-stage pure OCCC. The manuscript is concise and well organized. The topic is interesting
for readers. However, I have several concerns that need to be addressed before publication.
Major comments
1.  Line 90-91: I would like the author to reconfirm whether informed consent was obtained really
from ALL individual participants included in the study. I am afraid that it was very difficult due
to the nature of retrospective study with the long duration of the cohort (2008-2017). Did the
author obtain informed consent from the participants with short follow-up periods?
2.  Line 94: It would be better that the dosage and interval of postoperative chemotherapy were
described.
3.  Line 179-182: I do not think that reference 17 and 18 were appropriate in the current version,
because participants of the studies of reference 17 and 18 were completely different from those
of this study. Advanced ovarian cancer patients were analyzed in those two studies. I would like
the author to provide additional explanations in line with the intent of this manuscript.
4.  It would be better that data and discussion on adverse effects of chemotherapy and patient
quality of life were presented.
Minor comments
5.  Line 116: does “following chemotherapy” mean “postoperative chemotherapy”?
6.  The manuscript lacks descriptions of the definitions of staging system and histological
classifications in Materials and methods section.
7.  Line 112-113: does “the following two conditions” mean “two out of five”?
8.  Line 120, 145, 148, 150, 152, and 196: is “DFS” a typo? This abbreviation is not defined
in the manuscript
9.  Line 183-185: it would be better that references were given.
10. Table 3: what does “IA vs. IC vs. IIA” mean? Which is a referential parameter?
Title: Impact of the number of cycles of platinum-based chemotherapy for early stage  ovarian
clear cell carcinoma on survival: a retrospective study
Version: 1 Date: 24 Feb 2023
Reviewer's report:
A paper entitled " Impact of the number of cycles of platinum-based chemotherapy for early
stage pure ovarian clear cell carcinoma on survival: a retrospective study” was reviewed. The
authors found that the number of cycles of platinum-based chemotherapy was not associated
with a survival benefit for patients with early-stage pure OCCC. This study had ambiguities in
the selection of cases and the definition of histological subtype, and was not considered suitable
for publication.
Major points
1. In the 2020 world health organization (WHO) classification, the category of mixed carcinoma
of the ovary, which had been removed from the 2014 WHO classification, was reintroduced, and
clear cell carcinoma of the ovary and mixed carcinoma of the ovary were clearly distinguished
[1, 2]. Therefore, the words “pure ovarian clear cell carcinoma” or “mixed ovarian clear cell
carcinoma” were not appropriate for using in the manuscript.
2. Cases included in this study were diagnosed between 2008 and 2017, and diagnostic criteria
might change depending on the times. In addition, the literature referred to define clear cell
carcinoma of the ovary was outdated (Ref 15). Therefore, case selection should be performed
by conducting pathological review based on the 2020 WHO classification by pathologist.
Minor points
1. Representative images of clear cell carcinoma of the ovary had better be demonstrated in
Figure.
References
1. Lokuhetty D, White VA, Cree IA (eds). WHO classification of tumours of female reproductive
organs. IARC: Lyon; 2020.
2. Kurman RJ, Carcangiu ML, Herrington CS, Young RHE (eds). WHO classification of
tumours of female reproductive organs. Lyon, IARC, 2014.
Title: Impact of the number of cycles of platinum-based chemotherapy for early stage  ovarian
clear cell carcinoma on survival: a retrospective study
Version: 3 Date: 29 Mar 2023
Reviewer:  Yoshiki Ikeda
Reviewer's report:
The author has responded sincerely to the reviewers' comment and properly revised the
manuscript. I do have, however, some minor points, which should be taken into account before
this paper can be published.
1. Titles of Table 2,3,4: according to this revision, it would be better that the word, “pure” was
deleted.
2. Table 3: the author should clearly state, in Table 3 or in the main text, that IA is a referential
parameter.
Title: Differential expression of serum miR-363-3p in patients with polycystic ovary syndrome
and its predictive value for their pregnancy
Version: 0 Date: 07 Feb 2023
Reviewer's report:
I read with interest the paper Differential expression of serum miR-363-3p in patients with
polycystic ovary syndrome and its predictive value for their pregnancy. Authors aimed to explore
the role of microRNAs (miRNA) play a role in PCOS. They suggested that miR-363-3p levels
were reduced in PCOS patients. Compared with the PCOS pregnant group, miR-363-3p levels
were lower in the PCOS non-pregnant group. The authors suggest that low miRNA levels
are a risk factor for ovulation failure with PCOS. Authors describe in detail the material and
methods, results are well presented. Overall, an interesting manuscript but further clarification
and modification are necessary to be added.
-The use of abbreviations should be minimized in the abstract. Define each abbreviation in the
abstract in the first instance.
-This study is not rationalized well why authors selected miR-363-3p and how it is connected
with ovarian function and PCOS?
-Did the author ever explore the relationship between miR-363-3p content in peripheral blood
and follicles?
-Why all the control results have been corrected as 1?
-It is noted that this manuscript needs particular attention to grammar, detailed spelling, and
sentence structure. It’s better approved by native English experts.
Title: Differential expression of serum miR-363-3p in patients with polycystic ovary syndrome
and its predictive value for their pregnancy
Version: 0 Date: 17 Feb 2023
Reviewer:  Hanan Youssef
Reviewer's report:
The research topic is new and intersting. The  introduction is clear and concise
Materials and methods used are clear and well-written , results in the form of tables and figures
are clear. Discussion is  specific and precise.
Title: Prevalence of child marriage and associated factors among reproductive age women in
Harari regional state, eastern Ethiopia, 2022: Community-based study
Version: 1 Date: 20 Feb 2023
Reviewer's report:
# Review
- English proof editing is strongly recommended. There are many grammatical and typographical
errors throughout the text.
- The abbreviation EDHS in the Introduction section should be explained.
- The very last sentence in the Introduction section needs to be written more precisely: “As a
result, the focus of this research is to find out how common child marriage is in the study area
and what factors influence it”. Kindly be precise about which study area.
- The following percentage is not correct: “In terms of educational attainment, 487 (48.94 %)
of the women had no formal education…”. Additionally, those numbers are not in line with the
data in Table 1.
- The following statement needs to be written more precisely: “This study's findings were lower
than those of a community-based study in Injibara town (44.8%) and in Amahara regional state
by analysis of 2016 EDHS (48.57%) [22, 25]”. Instead of “This study's findings were lower” a
more appropriate term is suggested.
- The following statement is not clear: “This could be justified by not knowing the legal age can
result in practicing child marriage”.
- What are the limitations of the study?
- There is no need for asterisks and legends in Table 3.
Title: Prevalence of child marriage and associated factors among reproductive age women in
Harari regional state, eastern Ethiopia, 2022: Community-based study
Version: 1 Date: 26 Feb 2023
Reviewer:  Theresa Azonima Irinyenikan
Reviewer's report:
The manuscript brought to light the prevalence of child marriage in Harari, Ethiopia and the
factors responsible for this. This is a public health issue that really needs to be addressed.
However, there were some typographical/grammatical errors noted in the manuscript and  it will
be nice if the authors can make the corrections:
1.Line 97 can be corrected as occur
2. Line 105-twelve
3. line 123-selected
4. line 127-eligible
5.line 189 can be rephrased as participants being muslims had 2.3times higher odds
6.line 193 can be rephrased as women residing in rural areas had 5.3times greater likelihood
7. line 198 - 4.49 times higher odds to have
8.line 199-knew
9.line 212-it is
10.line 214- change to :  as against those aged
11.line 220- research
12. line 234-the higher the educational level
13. line 250- this finding
14. line 271- change to consent
Title: Prevalence of child marriage and associated factors among reproductive age women in
Harari regional state, eastern Ethiopia, 2022: Community-based study
Version: 1 Date: 01 Mar 2023
Reviewer:  António MacHado
Reviewer's report:
Reviewer report
Congratulations on the present study.
Comments:
Please replace "ORICID: 0000-0001-9406-1979 “ with "ORCID" and the number is not present
in the database.
"Many girls, and to a lesser extent, boys, marry without exercising their right to choose.
Some young females are coerced to marry." I recommend changing a little bit the title to the
general idea declare in the Abstract and Introduction sections by the authors. This is only a
recommendation, but I believe that it would increase the impact of the study.
Abstract
The is no need to write "At a p-value of 0.05, statistical significance was declared.", please
eliminate it.
Please add the total number of the group set and state demographic data, such as women's age.
Introduction
Line 70-Please rectify the sentence "There's also evidence that More than half of the girls ...".
Methods and Materials
Line 106- Please rectify the subtitle "Studydesign ,Settingand Period".
Line 117- Please clarify the period "during the study period".
Line 153- Please rectify the sentence"languages(Afaan Oromoo and Amharic  language)".
Lines 12-163- Please cite the references of the software applied in the study "into EpiData
version 3.1. Then, the data were exported to Stata version 16 for analysis. "
Results
Lines 175-179- "A total of 990 reproductive-age women were questioned, with a 99.6% response
rate. The women's median age was 22, with an interquartile range of 20- 25 and a range of
18 to 43 years. 793 (80.43 %) of the study participants were married. In terms of educational
attainment, 487 (48.94 %) of the women had no formal education, and 619 (62.78%) study
participants were Muslim (Table 1). "
Please state the underage women interviewed in the study and their range. This information is
not present either in Table 1.
The file of Figure 1 should not show the title of Figure 1 and also the legend plot shows a typo
error in "Aga". Please rectify Figure 1.
Line 184- Please rectify the subtitle "Prevalenceofchild marriage".
Line 186- Please rectify the subtitle "Factorsassociatedwithchild marriage".
Line 197- Please rectify the sentence "Those women who had been residing in rural areas
were5.39times[AOR: 5.39, 95% ..."
I strongly recommend merging the last 3 subsections of results due to the few sentences in the
first two subsections (1-3 lines).
Lines 385-386- Please rectify the title of Table 3 "Table 3. Bivariate and multivariable logistic
regression analysis for factors associated withchild marriageatHarari Regional State, Eastern
Ethiopia, 2022, (n = 986).".
Discussion
Please check the English editing and typo errors in the present section.
Also, please add the shortcomings of the present study at the end of the Discussion section.
Congratulations again on the present study.
Title: Prevalence of child marriage and associated factors among reproductive age women in
Harari regional state, eastern Ethiopia, 2022: Community-based study
Version: 1 Date: 02 Mar 2023
Reviewer's report:
Introduction
In the first paragraph add only definition of marriage and can add one line for expressing one
situation
Methodology
What do you mean in the title by Studydesign ,Settingand Period? Methods seems fine to me.
Results
Please revise the result section again and write it according to the paper format. Authors didn’t
write the results part precisely. Please revise it again.
Discussions
Discussion and conclusions part fine to me.
Title: Prevalence of child marriage and associated factors among reproductive age women in
Harari regional state, eastern Ethiopia, 2022: Community-based study
Version: 3 Date: 17 Apr 2023
Reviewer:  António MacHado
Reviewer's report:
Thank you for answering all my comments and questions. I endorse the revised manuscript,
however there is still grammatical errors and so I recommended the authors to review the English
editing of the manuscript before publication.
Best regards
Title: Serum concentrations of IL-16 and its genetic polymorphism rs4778889 affect the
susceptibility and severity of endometriosis in Nigerian women.
Version: 2 Date: 01 Jan 2023
Reviewer's report:
Major concern:
1. Why did the authors use a small sample size?
2. With such a small sample size, Classifying patients into 3 groups of mild, moderate, and severe
is not a good decision. In Table 2, I would like to know the number of patients in each group.
Minor concerns:
1. The manuscript needs extensive revision for language and grammar.
2. The title should be more specific based on your findings. I suggest something like  this" Serum
levels of IL-16 and its genetic polymorphism rs4778889 affect the susceptibility and severity
of endometriosis  in Nigerian women"
3. Some unnecessary sentences can be deleted from the abstract section. For example in the
method part "Their sociodemographic characteristics, symptomatology, and family history of
endometriosis were collected. A numerical rating scale was used for pain assessment in patients
with endometriosis. "
4. The thermal condition and the amount of each used material (primer, DNA template, water,...)
have to be added in the PCR section.
5. In table 2, one genotype should be considered as the reference, and the others are evaluated
based on it.
Title: Serum concentrations of IL-16 and its genetic polymorphism rs4778889 affect the
susceptibility and severity of endometriosis in Nigerian women.
Version: 2 Date: 15 Jan 2023
Reviewer's report:
The study is interesting and refers to immune changes observed in pts with endometriosis. The
study is well designed and the number of participants is appropriate.  After minor corrections
marked in red  the manuscript should be ready for acceptance.
1. anywhere in the text when you describe soluble agents in serum - the word "level" should be
replaced by "concentration"
2. page 3, row 16 - presence of…..is not characteristic for endometriosis only – about 90% of
women have menstrual debris containing endometrial glands and stroma during menstruation –
so it should be added active or functioning
3. page 4,  row 6 - "implicated" should be replaced by "postulated to play a role"
4. page 6, row 8 - it is difficult to construct a control group because we do not surgery for healthy
patients and because of heterogeneity.  It is better to use the term – reference group (near to
normal) - the control should be replaced also in tables
– some non endometriotic pathotologies also generate pain – so the reference group should be
better described
5. It should be described how do you define the ascites - in endometriotic pts the volume of
peritoneal fluid is higher (up to 100ml or even more)
6. page 12, rows 1 and 5- units of measure must be added
Title: Serum concentrations of IL-16 and its genetic polymorphism rs4778889 affect the
susceptibility and severity of endometriosis in Nigerian women.
Version: 2 Date: 23 Jan 2023
Reviewer's report:
The manuscript is well  written and  brings eruditely a very useful results about association
between proinflammatory cytokines (IL-6 and IL-16)  levels and genotypes/ alleles in IL-16
gene in Nigerian women with endometriosis. Surprisingly, IL- 6 levels and supposed  IL-6
genetic variability were not associated with any effects  on endometriosis susceptibility and/ or
severity evaluated  according to the pain score which could be useful in clinical practice. On
the other side, serum Il-16 levels as well as one polymorphism in IL-16 were associated  with
endometriosis as well as with pain severity.
In future, it is necessary to increase number of women in both groups to confirm the genetic
association in IL- 16 rs11556218 polymorphism with promising specificity (0.685 according to
my calculation). The authors know it as mentioned in Discussion.
My comments:
Were all phenotypes (characteristics from Table I)  associations with rs115556218 genotypes/
alleles tested? It could be interesting to add some information about it to the results even when
negative.
How possible  new genetic biomarker of endometriosis (the C allele of rs11556218 of IL-16
gene) will support or improve diagnosis/ treatment of endometriosis in  Nigerian women?
Title: Changes to Physical Activity Behavior during the COVID-19 Pandemic and their
Associated Factors: A Cross Sectional Survey of Mexican Women
Version: 2 Date: 20 Nov 2022
Reviewer:  Anna Zalewska
Reviewer's report:
Thank you for the opportunity to review this paper. The aims of this study were to determine
changes in PA participation practicing behavior(s) among Mexican women due to COVID-19
pandemic restrictions and to assess the potential factors associated with these changes. It is clear
paper and the  conclusions are sound. There is, however, few issues that must be resolved before
the study can be accepted for publication.
- Abstract:
Methods: „web-based global survey” – give more details
- All paper:
Use a different parenthesis when entering the reference number, i.e. „[…]; [4,6,21,22]”.
- Data collection:
Did the survey collect any socioeconomic status information and modifiable lifestyle behaviors
such as alcohol use and tobacco use? Along with physical activities, these factors have been
widely found to be related to depression.
„The survey was distributed via e-mail, the WhatsApp mobile application, and social media.”
- Was there a mailing list that the researchers used to distribute the survey via email? This
information is crucial for the readers to decide the profile of the target population and the quality
of the sample. A lot more information is needed.
Please, provide reference for Washington Group Questions (WGQ)  and the International
Classification of Functioning, Disability and Health (ICF)
There is a need to elaborate the inclusion and exclusion criteria of sample recruitment.
Title: Changes to Physical Activity Behavior during the COVID-19 Pandemic and their
Associated Factors: A Cross Sectional Survey of Mexican Women
Version: 2 Date: 18 Dec 2022
Reviewer's report:
Thank you for the opportunity to review this manuscript. The manuscript is well-written.
However, the manuscript can be accepted after further revision.
1. Please shorten the abstract.
2. Literature review is not adequate. Some important references are missing. Please expand it
logically.
3. Clearly state your research questions and objectives.
4. Sample size determination is missing.
5. It is advised to mention dependent and independent variables in the methodology section,
along with defining the potential confounding variables.
6. Crudes and adjusted result should be mentioned clearly to compare the differences.
7. Write implications of this study findings.
Title: Changes to Physical Activity Behavior during the COVID-19 Pandemic and their
Associated Factors: A Cross Sectional Survey of Mexican Women
Version: 2 Date: 03 Feb 2023
Reviewer's report:
Thank you for the possibility to review this paper. The topic is interesting, however the paper
needs to be extensively corrected.
The manuscript contains fundamental errors that cannot be rectified through author revisions.
To conduct Health Impact Assessment it is necessary to perform the initial diagnosis and be able
to investigate the late effects of the changes to physical activity, for example. This way it will
be possible to systematically monitor the effects on health.
In general terms, the purpose of the study is not clear, whether it was to determine the impact
of the changes in PA on self-perceived physical and mental health o assessing the COVID-19
pandemic’s impact on PA behaviors and possible associated factors, self-perception of mental
and physical health among Mexican women.
In addition, there are problems in the methods, in particular, there is no clear description
of the variables, it is not clear how the self-perception of physical and mental health was
measured before and during the pandemic, it is not clear how (functioning and participation)/
disability levels with the Washington Group Questions (WGQ) was categorized, there is a lack
of information on the variables associated with changes in PA.
Title: Changes to Physical Activity Behavior during the COVID-19 Pandemic and their
Associated Factors: A Cross Sectional Survey of Mexican Women
Version: 2 Date: 09 Feb 2023
Reviewer's report:
I appreciate the study topics and would like to thank the authors for thinking about the research.
However, I found some major issues in this article. My general thoughts are listed below:
1. The title of the study should be clear. There have some missing words or grammatical
mistakes.
2. In the abstract, authors should include what types of statistical analyses they use for their
study.
3. In the introduction, the entire writing should be more constructive and need more supportive
materials to define the lack of PA in women, the research gap, and the study's novelty.
4. In the method section:
- it has been mentioned that it was an international survey; why the author chose Mexico?
- how did the authors adopt similar settings for different places?
- I didn't find any description of dependent variables (physical or mental health).
- how did authors categorize PA as a low, moderate, and high scale? Does it have any
justification?
5. In the result section:
- why they divided the age group based on 40 years old? Have there any reasons behind it?
- in Table 3, there should be several factors between employed women and students engaging
in PA. They should not be considered one category.
- I didn't find any results based on linear regression that was mentioned in the analyses section.
In the current state, I am rejecting the article. I hope the authors will be more constructive in
writing and presenting the results before further submission. Thanks.
Title: Pre-eclampsia during pregnancy and risk of endometrial cancer: A Systematic Review
and Meta-analysis
Version: 2 Date: 22 Feb 2023
Reviewer's report:
Jordao H1*, Herink K1*,  Eastwood KA1,2, McVicker L1, Kearns C1, McMenamin ÚC1.
Why are there two corresponding authors?
Search Strategy: Two independent reviewers screened titles and abstracts of studies identified
in MEDLINE, Embase, and Web of Science databases from inception until March 2022.
Usually, we don't have segmentation in the article summary method
Selection Criteria: Studies were included if they investigated pre-eclampsia  and subsequent risk
of endometrial cancer (or precursor lesions).
It would have been better to mention the number of articles found on the sites in the results
section
Funding: ÚCM and HJ are funded by a UKRI  Future Leaders Fellowship (MR/T019859/1).
The funders had no role in the conduct of the study or the interpretation of the findings.
These abbreviations should be mentioned in full before in the text.
Where is Table 2? We only have Table 3 in the attached files section
Where is figure 1?
where is figure 2?