Reviewer ’s report  
 
Title: Number of Parity Is Associated with Low -Grade Albumin uria in Middle -Aged and Elderly 
Chinese Women  
 
Version: 2 Date: 09 Jul 2019  
 
Reviewer: Kirk P. Conrad  
 
Reviewer's report:  
 
The authors have adequately responded to many of the reviewer comments. However a few 
concerns remain.  
 
(1) The authors were asked whether microalbuminuria (ACR>30 mg/g) was associated with 
parity. They showed in their responses that this was indeed the case (Fig. S1, Table S1). 
However, the data were not included in the manuscript. I think these data are interesting, and 
could be mentioned in the Results. The data could be included as a Supplementary Figure and 
Table as they presented to the Reviewers.  
 
 
(2) Results, p. 10, para 2. Authors state that logistical regression analyses were significant for 2 
live births, but this seemed to be the case only for Model 1?  
 
 
(3) Discussion, p. 10, para 2. It is still not clear to me why eGFR showed a positive relationship 
with albuminuria? Prodromal renal hyperfiltration?  
 
 
(4) Discussion, p. 11, last para. Authors refer to "previous studies". Could they please cite these 
previous studies here?  
 
 
(5) Discussion, p. 12, line 235. "fertility"?  
 
 
(6) Discussion, p. 12, line 241. "re sult" or "reflect"?  
 
 
(7) Discussion, p. 13, lines 251 -4. This explanation see ms a bit of a stretch.  
 
 
(8) Discussion, p. 13, line 264. What "unhealthy lifestyle charact eristics" are you referring to. 
Smoking and ETOH?  
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections b efore being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content o f the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization th at 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any  non-financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
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including any attachments I upload will be posted on the w ebsite along with the authors' 
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