Reviewer ’s report  
Title: Levonorgestrel -releasing intrauterine system for treatment  of heavy menstrual bleeding in 
adolescents with Glanzmann's Thrombasthenia: Illustrated case series  
 
Version: 0 Date: 30 Jul 2017  
 
Reviewer: Amr Mahran  
 
Reviewer's rep ort: 
This manuscript presents a case series of two Glanzmann's Thrombasthenia patients with heavy 
menstrual bleeding treated by Levonorgestrel -releasing intrauterine system. The authors 
concluded significant improvement of both cases.  
This manuscript tackl es an interesting topic which might be of interest for BMC Women's Health 
Journal readers. Although Levonorgestrel -releasing IUD has been evaluated for the treatment of 
other inherited bleeding disorders e.g. von Willebrand's disease, it is the first time to be tested in 
patients with GT. However, there are few comments the authors, they need to address.  
 
Specific comments:  
* Grammar/ word falls:  
- Page 3, line 43: "are" well demonstrated.  
- Page 4, line 24: No comma after Since.  
- Page 6, line 7: missing co mmas before and after "therefore".  
- Page 6, line 48: "are" the diagnostic criteria.  
- Page 6, line 55: the need "for" hospitalization.  
- Page 7, line 14: analogs instead of "analogues"  
- Page 7, line 41: LNG -IUS with or without the use of an anti -fibrinol ytic agents "has" also 
been used to reduce bleeding.  
- 
 -up. 
- 
  
- 
  
- Page 9, lines 56, 56: Missing th e before treatment.  
* Page 5, lines 26 -28: I suggest merging them with lines 45 -48 and rephrasing the sentences.  
* I hoped the authors to report the follow up hemoglobin as an indicator for the improvement.  
* 2nd Case: I wished the authors to include the ultrasonographical findings before and after the 
insertion of the LNG -IUS. 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
Yes 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
Yes 
Are the conclusions drawn adequately supporte d by the data shown?  
If not, please explain in your comments to the authors.  
Yes 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please spe cify what aspects require further 
assessment in your comments to the editors.  
Not relevant to this manuscript  
Quality of written English  
Please indicate the quality of language in the manuscript:  
Needs some language corrections before being published  
Declaration of competing interests  
Please comp lete a declaration of competing interests, considering the following questions:  
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publication of t his 
manuscript, either now or in the future?  
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
3. Do you hold or are you currently apply ing for any patents  relating to the content of the 
manuscript?  
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
5. Do you have any other financial competing interests?  
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have no compe ting interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
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