JerMa88/BMC_Womens_Health_Peer_Reviews huggingface dataset:
Title: Long-term outcomes of non-metastatic Breast cancer patients by molecular subtypes
Version: 1 Date: 13 Apr 2022
Reviewer:  Christopher Pyke
Reviewer's report:
This is a retrospective cohort study  of 1287 patients diagnosed with Breast cancer and treated
at a single institution. There was no clear hypothesis - this seems to be a validation study.
Methods:
- retrospective cohort
- follow up as complete as possible with mail out/phone contact
- subtyping by IHC, Her2 by "ISH"
Were there any patients receiving Neoadjuvant chemotherapy?
Was anti - Her2 directed therapy offered to any  patients with Her2 positive tumours?
Results:
- there appear to be no exclusions - that is, follow up seems complete. How was this cohort
selected?  Were there any exclusions of other patients treated during this time with incomplete
data? ( this was alluded to in the last line of the "Discussion"
- apart from triple negative cancers,  biology ( molec subtype) did not offer superior prognostic
information than stage on univariate analysis
Discussion:
- good international comparison
-  is there a biological hypothesis why Iranian patients would be different to other cohort?
- Why was the "subtype" not a strong pognosis factor apart from Her2 positive?
-  the authors could discuss the weakness of using IHC as  a surrogate for  Luminal subtype
Figures and tables: good
Title: Long-term outcomes of non-metastatic Breast cancer patients by molecular subtypes
Version: 1 Date: 24 Apr 2022
Reviewer's report:
The research entitled "Long-term outcomes of non-metastatic Breast cancer patients by
molecular subtypes" is an interesting, well written article that fits the BMC Women´s Health
aims and scopes. It is suitable for publication after a minor review.
- Page 2 line 37 - 200 patients died (200/1287 = 15,5%) - please check the percentage
- Page 5 line 105 - I suggest you detail what was considered a family history  of cancer (only
first degree relative? Any type of cancer in the family?)
- Table 1: This table has valuable information but is not easy to read and understand. I suggest
you review the format of the table to facilitate reading.
- Table 1 - lymph node metastasis: This can be a factor of confusion because it is well known
that axillary status influences survival. I think this should be discussed in the discussion section
and maybe analysed in the results (survival of lymph node positive versus negative patients).
- Table 1 - Why did HR negative patients receive hormone therapy? This knowledge was not
available at the time of the study? I think you should briefly explain in the results or discussion.
- Table 2 - "Mortality N=134" - I was confused because earlier in the text you stated that 200
patients died. Please check.
- Page 15 line 266 - I think it would largely enrich your results if you had the percentage of
HER2+ patients that received trastuzumab. This is crucial to the survival rates in this subtype
of breast cancer patients.
I suggest some minor writting review as follows:
- Page 3 line 53 - "In 2020 over two million women (are) WERE diagnosed with breast cancer
worldwide".
- Page 3 lines 55-56 - please consider reformulating this statement because it is not clear to
understand.
- Page 4 line 96 - "Patients" (capital letter)
- Page 5 line 113 - "The molecular subtypes (was) WERE defined".
- Page 7 line 150 - "64%" - the sentence starts with a number - please check
- Page 13 line 214 -" Other associated factors with worse short-term DFS (were) included larger
tumor size "
Finally I think you have some very interesting epidemiological data that could be better explored
in the discussion section - the very young age of the patients and the impact of obesity in survival.
Title: Earning pocket money and girls’ menstrual hygiene management in Ethiopia: a systematic
review and meta-analysis
Version: 3 Date: 25 Mar 2022
Reviewer:  Belayneh Mengist
Reviewer's report:
Thank you for inviting me to review this manuscript. Review of earning pocket money and girls’
menstrual hygiene management is a public health important issue and has potential relevance
to other countries with a similar socio-economic profile. However, there are fundamental
comments to be addressed before publication.
Why you are interested to focus only on income, it would be nice if you included other factors
such as knowledge on sanitary materials, educational status of her family, etc which potentially
affect menstrual hygiene management to have comprehensive findings.
1. The introduction section can be better motivated and more succinctly presented. There are
some repetitions, irrelevancies, and some difficulties to follow statements.
2. The review has some fundamental methodological limitations;
• The primary studies were used different reference categories. Therefore, merging/pooling such
studies does not give a valid estimate.
• PICO statement should be clearly indicated
3. It is better to include reference categories of the included studies. Use either menstrual hygiene
management or menstrual hygiene management practice consistently.
4. In the discussion section; where possible, please refrain from generalizing. For example;" In
some occasions, sex for money was reported among 15-year-olds, with the proportion being
higher among girls who rely on their families for a living." Better to focus on the outcome
variable.
5. Reference
Please use the appropriate citation style. For example; ”How Menstrual Hygiene Management
Impacts Girls in the Ethiopian Lowlands | DT Global [Internet]. [cited 2021 Sep 21]. Available
from: https://dt-global.com/company/blog/may-28th-2021/menstruation-health-ethiopia”
6. Throughout the article there are a number of grammatical errors, and in general the article
is quite cumbersome and verbose. I suggest the article undergo language editing before
resubmission
Title: Fatigue Have Impact on the Sexual Problems in Chinese Females with Systemic Lupus
Erythematosus
Version: 1 Date: 23 Apr 2022
Reviewer's report:
Dear authors,
This work aimed to examine fatigue, disease parameters, depression, quality of life, and sexual
function in patients with systemic lupus erythematosus.  Some issues that they should consider
addressing before publication are described:
Firstly, the authors should include more information about the procedure. They should include
information about dissemination, sample collection, informed consent, whether participation
was voluntary, and whether compensation was involved. Moreover, they should clarify if the
inclusion criteria were the same for the patients and control groups. And, they should indicate
the internal consistency of the sample of their study.
In the statistics section, a description of the order of the variables included in the regression
model is necessary.
In the results section, the statistic test (t-test, Mann-Whitney U, Chi-square) should be included
in Table 2 for each variable comparison. Also, the variables which had included in the regression
model should be mentioned in Table 3.
In the discussion section, the results of this work and previous evidence of demographic,
psychological, and clinical should be discussed, because only fatigue results are discussed.
Furthermore, the evidence of the fatigue in other medical issues could be included. On other
hand, the results of regression models need more discussion.
Finally, in the conclusion section, I recommend the authors highlight the results of the work in
the clinical and research area.
Title: Fatigue Have Impact on the Sexual Problems in Chinese Females with Systemic Lupus
Erythematosus
Version: 3 Date: 01 Jun 2022
Reviewer's report:
Thank the author to review the manuscript. I would like to indicate some suggestions:
I recommend including the values of internal consistency for each instrument which was used.
It is necessary to include more information on the order in which the variables were included
in the stepwise logistic regression analyses.
Furthermore, I encourage researchers to extend the conclusions of the study.
Title: Fatigue Have Impact on the Sexual Problems in Chinese Females with Systemic Lupus
Erythematosus
Version: 3 Date: 05 Jun 2022
Reviewer's report:
THank for the revisions, the MS appears substantially improved. However I think that a better
emphasis on the potential role of autimmune dysregulation and inflammatory process should be
cited to create a potential link between SLE low androgen level and inflammation. the authors
should spend a part of the discussion in emphasizing
the role of sex steroid in modulating anti-inflammatory response not only in male (J
Endocrinol. 2012 Jan;212(1):71-84. doi: 10.1530/JOE-11-0289. Epub 2011 Oct 18; Prostate.
2013 Jun;73(8):789-800. doi: 10.1002/pros.22623. Epub 2012 Nov 28; J Endocrinol. 2012
Jul;214(1):31-43. doi: 10.1530/JOE-12-0142. Epub 2012 May 4) but also in the female
counterpart (J Mol Endocrinol. 2020 Oct;65(3):109-124. doi: 10.1530/JME-20-0147)
Title: Hereditary ovarian cancer risk reduction: a retrospective evaluation of patient perspectives
and service provision at a regional hereditary gynaecologic cancer clinic 2006-2016
Version: 1 Date: 03 Apr 2022
Reviewer's report:
This is potentially an interesting study reporting on patient perspectives regarding counseling
services at a hereditary breast and ovarian cancer clinic in Nova Scotia, Canada. However, the
manuscript could greatly improve in its presentation of the population studied, methodology,
and results.  Below I describe some issues that should be addressed:
1) The introduction should give more background on Nova Scotia's population and hereditary
breast and ovarian cancer risk specific to the area.  How many women are diagnosed with breast
and ovarian cancer every year in the region? General estimates would predict that  10% of
breast cancer cases of the region would be carriers of high penetrance mutations, so it would be
interesting to have the expected number of carriers for Nova Scotia based on the number of cases.
2) More information on the service providers in the context of health care in the region would
be useful for readers.
3) Tables 2 and 3 should better present the results, with columns with the two groups being
compared and n (%) within cells representing number of individuals and proportion for each of
the factors tested. Additionally, chi2 test is not appropriate if cells have less than 5 observations,
which is the case for a few factors in table 2.
4) The results section enumerates  n/total (%) for each factor analyze. This is an exact repetition
of the information on the tables. The authors could narrate the %s instead of just repeating what
is on the table exactly and make the results flow better.
5) The authors do not include p value for the difference in mean age between those who
responded the survey and those who did not. An average age of 47 vs. 45 could be important in
the context of this population. Breast cancer history is quite different between the two groups,
even though not statistically significant, and history of prior RRBSO is different, so overall, it
looks like the respondents and non respondents might be different and therefore results might
not reflect the study cohort.
6) The authors refer to the majority of the population as of "Caucasian" ethnicity. This terms is
not precise (not sure what population this term defines, since it was originally used to refer to
people from the 'Caucasus' and then popularized as a synonym of 'White'). The authors use it as
an 'ethnicity' different from the other categories included on the table, but it is really not clear how
to interpret this classification. It would also help to understand this better if the authors explained
how this information was obtained. Was it from an open text question where participants were
asked "what is your ethnicity" or where they  given options to choose from?
7) Abbreviations sometimes are not spelled out and there are too many. It is best for readers if
authors only include a few really well known abbreviations.
Title: Hereditary ovarian cancer risk reduction: a retrospective evaluation of patient perspectives
and service provision at a regional hereditary gynaecologic cancer clinic 2006-2016
Version: 1 Date: 08 Apr 2022
Reviewer's report:
The article, "Hereditary ovarian cancer risk reduction: a retrospective evaluation of patient
perspectives and service provision at a regional hereditary gynecologic cancer clinic 2006-2016"
by Adolph, Et al. seeks to address patient's perceptions of multidisciplinary clinics tailored to
individuals with hereditary breast and ovarian cancer risk. Furthermore, the article  highlights
regional hereditary gynecological clinics have proven to be effective in increasing informed
decision making about risk reducing strategies for ovarian cancer among at risk patients who
are BRCA1/2 carriers.
The issue that this article seeks to address is clear by the way that is presented in the abstract.
However,  the body of the article does not necessarily address what the patients perceptions
about the specialty clinic were in a concise manner. The results show the reasons why patients
choose to opt in for risk reducing strategies for ovarian cancer, but it does not address  the
reason behind those answers. The article does briefly mentions patient's satisfaction with genetic
counseling services and having a multi-disciplinary team, but more data regarding this needs
to be illustrated.
Differentiation between BRCA1 and 2 could also help illustrate the data more clearly. Were
women who had a BRCA1 mutation more likely to undergo a hysterectomy vs. women who
were BRCA2 carriers? Was age of uptake for risk reduction surgery based on mutation status,
family history, and gene affected?
Although the article is innovating and highlights the importance of hereditary cancer syndromes
clinics is vital to motivate more health centers  to have these services available for patients,
including what is highlighted above can help the article make a more clear point. Additionally,
including psychosocial measures to identify how patients felt while having these difficult
conversations of undergoing preventative surgery  will make this article stronger for publication.
Overall the article highlights an important concept that needs to be addressed to improve quality
of cancer prevention management and care. However, more details are needed to  illustrate
patients perceptions towards these types of services.
Title: Hereditary ovarian cancer risk reduction: a retrospective evaluation of patient perspectives
and service provision at a regional hereditary gynaecologic cancer clinic 2006-2016
Version: 3 Date: 14 May 2022
Reviewer's report:
The authors have adequately answered most of my comments.
My only concern right now  is the Results section of the Abstract. It starts sentences with numbers
xxx/xxx(xx%) which is not usually considered appropriate in scientific writing. Can this section
be re-written following usual standards for writing? The methods section already states that the
total number is 200, so you do not need to include it as part of every result in the results section.
Example of how this could be re-written: "A total of 156 women (78%) were referred to HGRCC
of which 135 (85.9%) attended their appointment. Sixty two percent of participants were over
age 40 at the time of testing. ... ". This is an example, the authors can figure out the rest.
Title: Premenstrual syndrome incidence rate and risk factors among the working population in
the Republic of Korea: A prospective cohort study.
Version: 1 Date: 01 Jun 2021
Reviewer's report:
1. Please confirm that only 29 people died or lost track in figure 1?
2. Please provide crude HR for each item in table3.
3. I suggest that add Figure 3b for PMS annual incidence.
Title: Premenstrual syndrome incidence rate and risk factors among the working population in
the Republic of Korea: A prospective cohort study.
Version: 1 Date: 09 Nov 2021
Reviewer's report:
1. Please confirm the consistent about the number of subjects you analyzed in abstract, figure
2 and text.
2. Please show the incidence rate of PMS in abstract.
3. The hazard ratio in abstract should present with 95% CI.
4. Please interpret PMS and non-PMS characteristics with % of column in Table 1 and Table
2, it means the denominator should be 8,503 and 112,521 with PMS subjects and non-PMS
subjects, respectively.
5. As mentioned above, the result should be revised. Such as: "Of the 8,503 workers suffering
from PMS, the highest proportion were as follows: women aged 20-29 (67.7%)…"
6. About the health status, is there the hyperlipidemia data in your database?
7. Why you combine nerve or moderate drinking status, not separate or combine moderate with
severe?
8. Please clarify the numerator & denominator of PMS incidence by ISIC in figure2.
9. The age plays an important role in your study. You also could observe the cumulative
incidence of PMS's increase speed is reduced, from 0.94 to 0.67 by calendar year. The X axis
of cumulative incidence (Figure 3) could consider use age or follow-up time.
10. Please mentioned what covariates you adjusted in model in statistical analysis section and
below the table 3. Also, why you chosen these covariates, the “national health screening status”
not been included?
11. Please show the p value in Table 3.
Title: Premenstrual syndrome incidence rate and risk factors among the working population in
the Republic of Korea: A prospective cohort study.
Version: 3 Date: 22 May 2022
Reviewer's report:
Thank you for your effort to revise this manuscript. This article will make working women
aware of risk factors for PSM, includes teenage girl, manual workers, anemia, and underweight.
Combining these risk factors, we can be imagined that if a woman is too young (they often
neglect their health), they need to work but in a state of underweight and anemia (it may also be
due to insufficient nutritional intake), these will make her more likely to have PMS. In addition,
the insufficient nutritional intake and work itself can also be a vicious circle. May you have more
discussion or conclusion on this to remind and improve this population’ “health literacy”. One
last minor suggestion, please add “95% CI” in abstract when you describe the data, for example,
15–19 years old age group (2.81, 95% CI: 2.35-3.36) if within word limit.
Title: Exosomal tRF-Leu-AAG-001 Derived from Mast Cell as a Potential Non-invasive
Diagnostic Biomarker for Endometriosis
Version: 2 Date: 24 Apr 2022
Reviewer's report:
I read with great interest the manuscript, which falls within the aim of this Journal. In my honest
opinion, the topic is interesting enough to attract the readers’ attention. Nevertheless, authors
should clarify some points and improve the discussion, as suggested below.
Authors should consider the following recommendations:
- Manuscript should be further revised in order to correct some typos and improve style.
- Accumulating evidence suggests that immune cells, adhesion molecules, extracellular matrix
metalloproteinase and pro-inflammatory cytokines activate/alter peritoneal microenvironment,
creating the conditions for differentiation, adhesion, proliferation and survival of ectopic
endometrial cells. I would discuss these points in the light of new theories about the pathogenesis
of endometriosis, referring to: PMID: 31663401; PMID: 28100109
Title: Exosomal tRF-Leu-AAG-001 Derived from Mast Cell as a Potential Non-invasive
Diagnostic Biomarker for Endometriosis
Version: 2 Date: 29 Apr 2022
Reviewer's report:
despite good overall merit, I have some minor comments:
please introduce and discuss deeper about new insights regarding endometriosis'
pathogenesis (doi: 10.23736/S2724-606X.21.04788-2; 10.1007/s43032-020-00370-9;
10.1080/09513590.2020.1766440)
please list different types of endometriosis: ovarian, peritoneal and deep endometriosis and  also
rare cases of extrapelvic endometriosis (DOI: 10.1016/j.jmig.2012.03.005); include as limitation
the testing of biomarker  performance for the diagnosis of pelvic endometriosis only and the
lack of specific testing for different types of endometriosis.
please give some data about hormonal therapy for endometriosis (DOI 10.1016/
j.jmig.2011.04.008), potentially influencing marker's performance
Title: Association between dietary total antioxidant capacity and hypertension in Iranian
Kurdish women
Version: 1 Date: 23 Mar 2022
Reviewer's report:
Summary
This is a retrospective cohort study with the aim to investigate the association between total
antioxidant capacity (TAC) and hypertension in pre- and postmenopausal female.
Comments
A major concern is that the interpretation of logistic regression for the analysis of association
between TAC with hypertension. According to Table 4, none of TAC quartile was significantly
associated with hypertension (all p>0.05), however, the authors reported lower odds of
hypertension with higher quartile of TAC in both abstract and the results section of the
manuscript, which were an overinterpretation of results. Despite TAC as the primary exposure
variable in the study, the author pointed out and made conclusion on age and BMI from the
multivariate model. When interpreting results from multivariable model, the author should focus
on TAC, not adjusting variables in the model. I would also suggest a test for interaction between
pre/peri vs postmenopausal women on the association between TAC and hypertension before
the author conclude that the association differ between pre/peri vs postmenopausal women.
In addition, the author should address that with a cross-sectional design, they may not be abel
to make the conclusion on causality.
Title: Association between dietary total antioxidant capacity and hypertension in Iranian
Kurdish women
Version: 1 Date: 23 Mar 2022
Reviewer's report:
# Review
The main strength of the study is a large sample size of the examined women. The results
are clearly presented. The conclusions are supported by the study’s aim, methods and results.
However, there are some corrections in the manuscript that need to be done.
- English revision of the manuscript is strongly recommended.
- There are many grammatical and typographical errors (e.g. „peroxidants”,  „Body weight was
measured were measured”, „malonialdehyde”).
- In the Statistical analysis subsection, „p-level of significance“ should be defined.
- A correction is needed for the following statement „quantitative variables by mean±
standard deviation indices are presented and quantitative variables are reported in frequency
(percentage)”.
Title: Association between dietary total antioxidant capacity and hypertension in Iranian
Kurdish women
Version: 2 Date: 30 Apr 2022
Reviewer's report:
The authors tried to modify the content of the manuscript properly, but a the following point
should be considered to improve the manuscript:
Glycemic and lipid indices (variables) were not determinants of study outcomes. They were also
not considered as "exposure" or "confounding variables" in the current study. So these variables
are not essential variables for your study and should be removed from the Manuscript.
Title: Association between dietary total antioxidant capacity and hypertension in Iranian
Kurdish women
Version: 2 Date: 30 Apr 2022
Reviewer's report:
- The Authors have substantially revised the manuscript. However, there are still typographical
errors (e.g. „peroxidants”, „potentially confounders”, „malonialdehyde”) in the text, as well as
in the Results section [(OR = 081; 95% CI: 0.68, 0.98)] and in Table 4.