Title: A POPULATION BASED STUDY ON HUMAN PAPILLOMAVIRUS INFECTION
AND ASSOCIATED RISK FACTORS AMONG WOMEN OF THE REMOTE SOUTH
ANDAMAN ISLAND, INDIA
Version: 0 Date: 30 Jan 2024
Reviewer:  Subash Chandra Sonkar
Reviewer's report:
Dear Authors,
Article submitted for review and consideration of publication titled "A POPULATION
BASED STUDY ON HUMAN PAPILLOMAVIRUS INFECTION AND ASSOCIATED RISK
FACTORS AMONG WOMEN OF THE REMOTE SOUTH ANDAMAN ISLAND, INDIA".
I found article is interesting for readers, researchers and policy makers , manuscript is well
articulated and written with logical evidence based. However, I did not find any novelty work
in the manuscript rather Diagnostics using PCR and questioner based data generated in to
information's.
I have suggested some minor correction in manuscript and considered for acceptance.
Please Answer few questions and incorporate in MS as per requirements.
1.  Productive groups mentioned 18-59 years old in the study while some of the ICMR studies
mentioned 15-49 Years. Please check and cite proper reference.
2. In abstract,  Result, Prevalence value calculation check once again
3. In abstract, Conclusion, 50/1000 (5%) using terms high? Even 60 % in
Odisha reported https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216564/#:~:text=Prevalence
%20and%20analysis%20of%20risk,1).
chromeextension://efaidnbmnnnibpcajpcglclefindmkaj/https://hpvcentre.net/statistics/reports/
IND.pdf
4. Statements ; . High-risk human papillomavirus (HR-HPV) is linked with almost 99% of
occurrences of cervical cancer as per the WHO factsheet, 2020.  Supporting Reference need to
be mentioned.
5. There are approximately 200 distinct HPV genotypes known. cite proper reference
6.The majority of the residents of these islands are from various parts of India, including six
indigenous tribes with different socio-demographic and lifestyle characteristics. cite proper
references
7. The study was approved by the Institutional Human Ethics Committee and samples were
collected with written informed consent from all participating women. Please  mentioned ethical
number.
8. In Discussions,  Vaccination effectiveness is also need to assessment, various region
responsible, need to cite proper supporting article like;
A significant correlation of TNFA rs361525 polymorphisms with oral pre-cancer in the North
Indian population and with reproductive tract infections in women has been reported cite
(doi: 10.1038/s41598-020-79963-y).
Sharma, Vineeta, Subash Chandra Sonkar, Showket Hussain, Pallavi Singhal, Anoop Kumar,
Shweta Sharma, Sanjay Gupta et al. "Impact of oral contraceptives and smoking on the
susceptibility of Reproductive Tract Infections (RTIS) in immunosuppressed women: a hospital
based study." Int. J. Curr. Microbiol. App. Sci 4, no. 12 (2015): 363-374.
9.  Performance of the PCR assays also varies, so mentioned limitation too and cite supporting
reference. PCR methods performance also wariies and its depends on samply types and sets of
primers including other factors Eg, Sonkar, S. C., Yadav, S., Malla, N., Dhanda, R. S., Khurana,
S., Bagga, R., ... & Yadav, M. Evaluation of DNA Based Techniques for the Diagnosis of Human
Vaginal Trichomoniasis in North Indian Population.