Reviewer’s report
Title: 
Perimenopausal women show modulation of excitatory and inhibitory
neuromuscular mechanisms
Version: 
0 
Date: 
02 Nov 2020
Reviewer's report:
I read with great interest the Manuscript titled "Perimenopausal women show
modulation of excitatory and inhibitory neuromuscular mechanisms" (BMWH-
D-20-01029). 
I was particularly pleased to review this paper. In my honest opinion, the topic is
interesting enough to attract the readers' attention. Nevertheless, the authors
should clarify some points and improve the discussion citing relevant and novel
key articles about the topic and discussion limitations of the study that are not
evidenced in the discussion.
In general, the Manuscript may benefit from several major revisions, as
suggested below:
- All the text needs a language revision to improve some typos and grammatical
errors.
- Abstract. I would suggest defining early and late perimenopause.
- Lines 105-107. I would suggest better clarifying the reason underlining the
study hypotheses. Is there evidence or only a hypothesis of the authors?
- Lines 123-129. Do these lines refer to the ERMA-study or the present study?
- Line 131. Does "did not use" refer to the entire life of the women?
- The definition of premenopausal and early, late, and postmenopausal needs to
be better described. The adoption of two cuts off for each definition should be
clarified to allow reproducibility. 
- Lines 321-327. How may the variability of the FSH level during the menstrual
cycle have affected the observed association with twitch force?
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
No
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
No
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes