Reviewer ’s report  
 
Title:  Effect of periodontitis on the development of osteoporosis: Results from a nationwide 
population -based cohort study (2003 -2013)  
 
Version: 0 Date: 08 May 2017 
 
Reviewer:  Santiago  Palacios  
 
Reviewer’s report:  
 
It is a study in which the concept has a clear interest, however some changes must be made in 
terminology and structure.  
 
 
The corrections are:  
 
1.- To change the word "obvious" in the Conclusions, at the Abstract.  
 
2.- To change the word "Background", by Introduction.  
 
3.- In the last paragraph of the Introduction, the authors put "shoulder", and should be removed, 
since it is not one of the most typical fractures.  
 
4.- The incidence of osteoporosis in other countries is n ot relevant in the Introduction, therefore, 
except for Korea, the rest remove it.  
 
5.- Data on the prevalence of osteoporosis in men and women in Korea do not correlate with 
those found in the study. It should be explained.  
 
6.- There is an incomplete phrase  in the Introduction (paragraph 3): "The prevalence rates of 
periodontitis overall and among results 20+ years ..." Please complete.  
 
7.- In the Introduction they should change "predictor" by "risk factors", and add, as a factor, the 
genetic.  
 
8.- In Materia ls and Methods, they point out that there are more men than women with 
osteoporosis. This should be explained since osteoporosis is more prevalent in women.  
 
9.- In the definition of osteoporosis, the authors refer to "pathological factors" .... all fractur es are 
pathological, so I understand that they refer to those not related to trauma.  
 
10.- There should be a table summarizing the most relevant data, statistically significant, related 
to osteoporosis and periodontitis.  
 
11.- In the Discussion, it is pointe d out that periodontitis is a strong indicator of the risk of 
osteoporosis. I think "strong indicator" is exaggerated, since the relative risk they point out is 
high.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are re quired in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language correct ions before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past  five years received reimbursements, fees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, fun ding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
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