Reviewer ’s repo rt 
 
Title: HPV Vaccine in the Treatment of Usual type Vul val and Vaginal Intraepithelial 
Neoplasia: A Systematic Review  
 
Version: 1 Date: 20 Nov 2018  
 
Reviewer: Annarosa Del Mistro  
 
Reviewer's report:  
 
The authors addressed all my p revious comments and fulfilled the requests.  
 
 
 
Anyway, I would suggest the following modifications:  
 
- page 10, line 15: "Two of the studies...." changed as "In two of the studies the women had 
a mean age........."  
 
- page 10, line 29: add the sentence "The stud ies showed heterogeneity in the number of 
patients included (12 to 29) and disease duration prior to vaccination (3 months to 7 
years), while the follow -up was equally short (1 -12 months) in all."  
 
 
- page 11, lines 39 -40: it is not clear what "histological c learance" means; I would suggest 
to modify the sentence as "Histological HPV status and clearance did not seem............."  
 
 
- page 13, lines 27 -29: the sentence "In addition, for the primary..................." refers to the 
prophylactic vaccines, and shou ld be deleted.  
 
 
- page 14, line 49: "Vaccines may..........." should better be changed as "Primary prevention 
through prophylactic vaccination may.........."  
 
 
 
 
 
 
 
 
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the autho rs. 
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the edito rs. 
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable   
 
Declaration of competing interests  
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1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financial ly from the publication of this 
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3. Do you hold or are you currently applying for any patents  relating to the content of the 
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4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
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If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
  
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to the editor s, which will not be published.  
 
I agree to the open peer review policy of the journal