JerMa88/BMC_Womens_Health_Peer_Reviews huggingface dataset:
Title: A POPULATION BASED STUDY ON HUMAN PAPILLOMAVIRUS INFECTION
AND ASSOCIATED RISK FACTORS AMONG WOMEN OF THE REMOTE SOUTH
ANDAMAN ISLAND, INDIA
Version: 0 Date: 30 Jan 2024
Reviewer:  Phuc Nhon Nguyen
Reviewer's report:
Dear authors,
Thank you for addressing the HPV-contaminated status and risk factors related to this
contamination in the region of the authors. The study was well-presented, however, some points
are necessary to be clarified as the concerns below:
-A study flowchart with number cases of inclusion and exclusions should be given.
-The prevalence is an important result and should be described by 95%CI for common
prevalence and HPV type 18.
-Vaginal discharge needed to differentiate from vaginitis.
- Post-menopausal bleeding needed to be differentiate from uterine pathologies such as
intra-cavitary uterine pathologies. (Nguyen PN, Nguyen VT. Evaluating Clinical Features
in Intracavitary Uterine Pathologies among Vietnamese Women Presenting with Peri-and
Postmenopausal Bleeding: A Bicentric Observational Descriptive Analysis. J Midlife Health.
2022;13(3):225-232. doi:10.4103/jmh.jmh_81_22).
-The value of HPV test using in this study is required to mention as a reliable tool. The
technique of sample collection should be more detailed. For example, before sample collection,
the participants should avoid sexual intercourse or cleaning the vagin by hygiene liquide, etc.
-Contraceptive methods should be added since condom use was related to sexual transmitted
diseases.
-Co-test should be discussed. (Jans L, Zetterström K, Bergengren L, Helenius G. The value of
adding a single co-test in HPV primary screening. Prev Med. 2021;149:106617. doi:10.1016/
j.ypmed.2021.106617)
-The sample collection were performed by many clinicians at different centers, this bias should
mentioned in limitations of the study.
-Other types of HPV were not included, this may also become a limitation in screening strategy.
-HIV is a common transmission along with HPV, however, it was not included in the data. Please
add it. (Pérez-González A, Cachay E, Ocampo A, Poveda E. Update on the Epidemiological
Features and Clinical Implications of Human Papillomavirus Infection (HPV) and Human
Immunodeficiency Virus (HIV) Coinfection. Microorganisms. 2022;10(5):1047. Published
2022 May 18. doi:10.3390/microorganisms10051047)
- Some other variables such as occupation, level of school, income/salary per month should be
added besides literate/illiterate, employed/unemployed. Since the education and assessment to
health care settings may be different.
-Result part was too long. Please focus on risk-factor-related findings.
-The conclusion should be shorten and focus on the relevant findings. For example:
“Precancerous lesions and squamous cell carcinoma of the cervix were found to be significantly
associated with HPV positivity and high-risk HPV16.”, this conclusion was not mentioned in
the result.
-Some abbreviations such as PHCs, CHCs needed to be explained through the main text.
Best regards,
Title: A POPULATION BASED STUDY ON HUMAN PAPILLOMAVIRUS INFECTION
AND ASSOCIATED RISK FACTORS AMONG WOMEN OF THE REMOTE SOUTH
ANDAMAN ISLAND, INDIA
Version: 1 Date: 07 Feb 2024
Reviewer:  Phuc Nhon Nguyen
Reviewer's report:
Dear authors,
Thank you for all your responses to my concerns.
The  paper is improved now.
Best regards,
Phuc Nhon Nguyen MD,
Tu Du Hospital, Ho Chi Minh City, Vietnam
Title: A cross-sectional study observing the association of psychosocial stress and dietary intake
with gut microbiota genera and alpha diversity among a young adult cohort of black and white
women in Birmingham, Alabama
Version: 2 Date: 09 Nov 2023
Reviewer:  Roshonda B. Jones
Reviewer's report:
Knight et al. aims to examine gut microbiota of young, healthy black and white women and
the association of diet and stress with their gut microbial profiles. This work is much needed
because while there has been studies that have shown differences in gut microbiome by race it is
important to factor in differences in stress which can possibly explain differential gut microbial
profiles.  I have a few questions/comments that I would like to see addressed.
-How many patients were on the triphasic and if only a few have you all done a sub analysis to
remove them to determine if the results are the same regardless of triphasic use.
-In the “Gut Microbiome” section of the methods there is mention of a “Qiime based
pipeline21”…what is pipeline 21?  Is the 21 supposed to be there or is this a typo?
-One index of alpha diversity that is representative of microbial richness is explored here
but have you examined Shannon Diversity Index or Pielou’s evenness index to examine the
distribution of microbial abundance? It would be informative to see if stress is associated with
high or low evenness in this cohort.
-Have you examined beta diversity and clustering of gut microbiomes for this study? While you
have shown that association between life stress variables and individual gut microbial features
(ASV count and genera) are detected it would be interesting to see if life stress variables is
associated with the overall separation of microbial communities between the participants.
Title: A cross-sectional study observing the association of psychosocial stress and dietary intake
with gut microbiota genera and alpha diversity among a young adult cohort of black and white
women in Birmingham, Alabama
Version: 4 Date: 09 Feb 2024
Reviewer:  Roshonda B. Jones
Reviewer's report:
The authors adequately addressed my comments and concerns. In the current state, I believe the
manuscript should be accepted for publication.
Title: Association between bacterial vaginosis with human papillomavirus in the United States
(NHANES 2003–2004)
Version: 3 Date: 16 Oct 2023
Reviewer's report:
It is a generic article, that represents a prevalence in a given population, which may be
representative due to the relatively large number of the population studied.
In the methods used, HPV genotyping was performed, however, the data was not compiled in
the article. This data would be very relevant because not all types of HPVs will lead to the
development of cervical cancer. Therefore, associating vaginosis with HPV types would be
important information to understand better this relationship in this population and the risk of
developing cervical cancer.
Some references are very old, and I recommend that they be reviewed, especially when it comes
to statistics on cervical cancer.
To be accepted, I recommend adding genotyping data and making some changes to the writing
of the text, in addition to the formatting.
Title: Association between bacterial vaginosis with human papillomavirus in the United States
(NHANES 2003–2004)
Version: 5 Date: 30 Dec 2023
Reviewer's report:
This revised manuscript is greatly improved.  Many of the concerns raised by this reviewer have
been addressed.  A number of issues remain, however.
1. Is the corresponding author’s last name Dai or Da? (it is spelled both ways on the title page)
2. Line 45.  The sentence ending needs a period.
3. Line 62.  The word “as” is missing.  A result was defined either as BV confirmed….
4. Line 70.  Replace “at” with “for” ….were tested using Roche Linear Array HPV Genotyping
for HPV DNA.
5. The HPV positivity rate among women without BV is reported differently on line 105
(43.46%) and 108 (44.72%, which is not correct) and there is no need to report this twice.  I
suggest deleting the sentence which starts in line 105 and making sure you quote the correct
percentage.
6. Figure 1 title needs correcting – perhaps “HPV prevalence by BV status”.
7. Figure 1 – there is no need to show a bar for HPV- percentage (blue bars), since it can
be determined as 1- HPV+ percentage (orange bar).  I suggest deleting the blue bars as it is
misleading and distracting. Issue 5 above proves the point, as you misinterpreted your own data
in the figure.
8. Figure 2 is quite nice, but it needs a title.
9. Figure 2 replicates Table 2 in all ways.  Both are not needed.  I suggest keeping Figure 2
and deleting Table 2.
10. Discussion – Line 165.  You say that the association between BV and HPV might be
influenced by age, BMI, and ethnicity.  However, you only found that ethnicity influenced the
association, as the other two factors were not significant (p-value for differences by age was
0.36, for differences by BMI was 0.81).  You should rewrite this sentence to fit your findings.
11. Line 177 – the period is misplaced and it should be Mexican Americans (with an “s”).
12. Abstract and Discussion.  You have focused on the increased risk in Mexican Americans,
even though the risk in Non-Hispanic blacks (OR=1.81) was nearly identical to that of Mexican
Americans (OR=1.83).  It seems that your study should equally mention those two subgroups
throughout the manuscript.
Title: School-based Comprehensive Sexuality Education for Prevention of Adolescent
Pregnancy: A Scoping Review
Version: 1 Date: 06 Oct 2023
Reviewer:  Michael T. Mbizvo
Reviewer's report:
Manuscript: School-based comprehensive sexuality education (CSE) for prevention of
adolescent pregnancy: a scoping review
Comments:
General: The paper addresses an important topical subject on studies that have addressed
CSE, using a scoping review from 75 studies. These are drawn from diverse study designs,
including RCTs, Cluster randomized studies, controlled before and after, among others.  The
main “outcomes” reported are frequencies of topics covered by the studies reviewed, and less
mention is made on actual outcomes from the CSE interventions identified, such as number of
studies reporting pregnancy reduction as an outcome.
Specific:
1. The study would benefit from emphasis not just on what interventions were reported by
these studies, but more importantly, what outcomes were reportedly achieved by CSE, i.e.,
effectiveness of each, preferably stratified by study design. Such an approach would strengthen
the paper further and enrich the literature on this important subject, which remains controversial
in some settings, more from ideological perspectives, and less from research evidence.
2. Ref. line 24: Refrain from the assertion that CSE aims at “increasing contraceptive”, as it
goes beyond that and this falls into the trap of those opposed to CSE. Rather, it goes beyond
that, to instill values that help prevent unsafe sex, HIV risk, reproductive biology, risks of early
and unplanned pregnancy, improved gender power relations, agency and self-efficacy, among
others.
3. Address editorial errors, e.g., :
4. Ref. line 26: This sentence starting with “Previous reviews….”is incomplete.
5. Ref. line 30: Change “with emphasizing on” to “with emphasis on…..”
6. Ref. line 40: Change ……if there “are” to “were”.
7. Ref. line 82: Change……”and implement multicomponent….” To “while implementing”.
8. Ref. line 130: Change ….”with emphasizing” to “with emphasis on….”
9. Ref. line 131: ….Context “of”
10. Ref. line 279….Included, add “information” on
Title: School-based Comprehensive Sexuality Education for Prevention of Adolescent
Pregnancy: A Scoping Review
Version: 1 Date: 19 Oct 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
No - there are major issues
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
No - there are minor issues
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
No - there are major issues
STATISTICS - Is the use of statistics in the manuscript appropriate?
Not sure - I am not able to assess the statistics in this study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are major issues
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Maybe - with major revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The study has some merit to it but is unclear as to purpose and the
way the discussion manages the purpose. There are multiple areas that need clarification
REQUESTED REVISIONS:
The authors state the purpose is to map evidence. The typical purpose of a scoping review is to
identify gaps in the literature and where more research is needed. The authors took on a very
broad series of constructs that clearly identify gaps yet they did not propose the study in this
way. The mapping of evidence is not clearly delineated in the discussion with regard to the
results. The introduction nor discussion does not address the controversy of sex education in
schools with regard to religious and cultural considerations. Line 112 - why is there greater
need now? explain the urgency - this may be an opportunity to bring in how abortion right were
overturned in the US and how abortion, contraception and sex before marriage are hot topics in
many countries. The manuscript does not address diverse sexual and gender identities and what
education may look like that for that community. Line 127 - explain, verify and document why
previous reviews did not use UNESCO and why that is important for your study - use citations
of the previous reviews. Line 187 - the search was conducted more than 1 year ago - typically
scoping and systematic review update the search so that is less than 6 months prior to submitting
for publication. What years of publication were included (e.g. 1990- 2022?) and explain the
significance of the years. Line 202 - how was the abstract review conducted vs the full text?
Did two reviewers separately review all abstracts? Was Covidence or another software used to
manage this process? Finally, the abortion issue results in 3 studies - how can conclusions be
drawn from this small number? Clarify if the studies results were knowledge or self-reported
behavioral information.
ADDITIONAL REQUESTS/SUGGESTIONS:
The abstract has an incomplete sentence. Overall review for grammatical errors is necessary
Title: School-based Comprehensive Sexuality Education for Prevention of Adolescent
Pregnancy: A Scoping Review
Version: 3 Date: 12 Dec 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
No - there are minor issues
STATISTICS - Is the use of statistics in the manuscript appropriate?
Not sure - I am not able to assess the statistics in this study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The authors have been responsive to the prior reviews. A few issues
remain regarding lack of clarity on some points and overall awkward sentences and need for
review for grammar and syntax. Overall this is a well done, important manuscript
REQUESTED REVISIONS:
This manuscript reports on a scoping review of comprehensive sex education among available
manuscripts from across the globe. The authors have strengthened the manuscript with their
revisions but a few issues remain. 1. As noted in prior reviews, the introduction is too long and
heads in several directions that are not directly related to the purpose. 2. Line 60 - the WHO
reports the leading cause of death is pregnancy complications and unsafe abortions - the latter
is not included in this sentence. 3. Line 63 - define "modern contraception. 4. Line 116 - this is
an awkward sentence missing grammatical articles  it should read "the" unprecedented event;
have "a" huge impact. This sentence which was requested to be included by a previous reviewer,
only mentions the status of abortion in the US and would benefit from mention of the status of
abortion rights in the other countries cited in the scoping review. 5. Line 199 - what is meant by
"inception" can you provide the specific dates the reviews were begun and concluded. 6. lines
292-294 - it is unclear how the low VIP parent program or male circumcision is related to this
topic? 7. Figure 4 is not needed.
ADDITIONAL REQUESTS/SUGGESTIONS:
The language quality is not ideal and the introduction should be shortened
Title: School-based Comprehensive Sexuality Education for Prevention of Adolescent
Pregnancy: A Scoping Review
Version: 3 Date: 17 Dec 2023
Reviewer:  Michael T. Mbizvo
Reviewer's report:
Reviewer’s comments
Paper: School-based Comprehensive Sexuality Education (CSE) for Prevention of Adolescents
Pregnancy: A Scoping Review
General:
The revised paper, which essentially describes a literature review on studies that address
prevention of adolescents' pregnancy, places emphasis on contraceptive use, unplanned
pregnancy, and abortion to improve sexual and reproductive health and rights. It further
addresses knowledge gaps in the content and contexts of school based CSE. Included are papers
that have used RCTs, cluster RCTs, quasi-RCTs, Interrupted Time Series (ITS), and controlled
before and after designs. An earlier weakness was failure to include outcomes associated with
each of these interventions as designed, to better inform CSE programming and evidence-based
advocacy.
Specific:
1. The paper is much improved and makes reference to and quantifies studies by the type or
nature of outcome studied.
2. However, of the identified and included studies, readers would benefit from alluding to
results /outcomes of these outputs. Mentioning that this number of studies addressed or reported
on pregnancy or contraception as an outcome is incomplete. Rather, it's more complete to say
“this number or proportion of RCT studies that looked at unplanned pregnancy as an outcome,
reported a reduction (or no reduction) associated with CSE alone, or combined with XX, or
number and proportion reporting effect or no effect on contraceptive uptake.  Such outcomes
are available, including from RCT studies published in BMC Public Health.
3. I commend the authors for having updated their references, to include some studies up to
2023, while noting that the need to check on completeness of references.
Title: School-based Comprehensive Sexuality Education for Prevention of Adolescent
Pregnancy: A Scoping Review
Version: 5 Date: 22 Jan 2024
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The authors have been very responsive to the prior comments and
have done a commendable and thorough job of editing and reframing as suggested
ADDITIONAL REQUESTS/SUGGESTIONS:
Perhaps an overall review for syntax but much of that has been improved.
Title: Measurement of luteinizing hormone surge in vaginal discharge: a potential biomarker
that enables simple, non- invasive prediction of the fertile window
Version: 1 Date: 06 Oct 2023
Reviewer:  María Elena Alliende
Reviewer's report:
Confusion with some terms: fertile window, LH surge and LH peak.
I also provide bellow some other suggestions.
Detail:
Title: ...of the periovulatory period
Background: Predicting the periovulatory period...
...approaches to predicting the periovulatory period
Conclusion: predicting the periovulatory period
Introduction....Predicting ovulation
...predicting ovulation
uLH rises  between  (avoid sharply)
Include after the BBT, the cervix mucus  changes mentioned after. Those can also be
selfperceived  by trained women at the vulva.
...uLH surges were identified (eliminate peaks)
...surge maximum (peaks)
Increases in uLH counted as surges (eliminate peaks)
...counted as surges (eliminate peaks)
Figure 1: filtered out weak LH increases (eliminate peaks)
uLH Peak: For the 34cases  with corresponding  VD samples of vLH I would describe also the
peak pattern.
Figure 3 legend ...measuring vLH and uLH (abbreviations already introduced)
ulh predicting ovulation day
Title: Measurement of luteinizing hormone surge in vaginal discharge: a potential biomarker
that enables simple, non- invasive prediction of the fertile window
Version: 1 Date: 26 Oct 2023
Reviewer's report:
Review
Title: Measurement of luteinizing hormone surge in vaginal discharge: a potential biomarker
that enables simple, non-invasive prediction of the fertile window
Above research is needed to explore more user-friendly options to detect the time of ovulation.
However, there are come concern regarding sample storage.
Those are followings –
Line 92 : Authors need to provide temperature of the cooler place in line #92.
Line 102: Authors need to provide temperature of the cooler place in line #102.
There need to be a table in result section which will show the sensitivity and specificity.
A careful revise is needed to avoid typos for example -
Line 76: would be “from”
Line 241: “average” would be deleted.
Title: Systematic Review and Meta-Analysis of the Etiology of Menorrhagia in 2,770 adolescent
females
Version: 1 Date: 17 Oct 2023
Reviewer:  Dvora Bauman
Reviewer's report:
there is some confusion between defenitions of Heavy menstrual bleeding/menorrhagia and
abnormal uterine bleeding that consists on HMB and  ireggular/ menstrual bleed
the term : Ovarian Uterine disorders needs definition and reference
the big number
"no identifiable etiology " is very high , almost  50% , not  reported so far , needs more
clarification
I would advice to emphasize what is the advantage / new information of this research
enclosed some comments in the manuscript
Title: Systematic Review and Meta-Analysis of the Etiology of Menorrhagia in 2,770 adolescent
females
Version: 3 Date: 08 Jan 2024
Reviewer:  Phuc Nhon Nguyen
Reviewer's report:
Dear authors,
Thank you for all your feedback.
Despite the limitations in data extraction, the paper is well improved after revision.
The revised manuscript could be considered for publication now.
Regards,
Phuc Nhon Nguyen MD, MSc,
Tu Du Hospital, Ho Chi Minh City, Vietnam