Reviewer’ s report
Title: Immunohistochemical staining of leptin is associated with grade, stage, lymph node
involvement, recurrence, and hormone receptor phenotypes in breast cancer
Version: 0Date: 12 May 2017
Reviewer: Dipali Sharma
Reviewer's report:
Multiple studies have shown that higher expression of leptin and leptin receptor correlates with
breast cancer progression. In this study, authors analyzed the expression of leptin in a cohort ofbreast tumor samples (449 cases of breast cancer and 27 samples of fibroadenomas and normaltissues). Overall, the study is well designed and focuses on an important research area.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
YesDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
Not relevant to this manuscriptQuality of written English
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Needs some language corrections before being publishedDeclaration of competing interests
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