JerMa88/BMC_Womens_Health_Peer_Reviews huggingface dataset:
Title: Abdominal obesity as assessed by anthropometric measures associates with urinary
incontinence in females: Findings from the National Health and Nutrition Examination Survey
2005-2018
Version: 0 Date: 30 Dec 2023
Reviewer's report:
This study represents a secondary analysis of the NHANES study, aiming to explore the
association between adiposity indexes and the prevalence and severity of urinary incontinence.
The authors meticulously conducted an analysis, incorporating data from seven NHANES
questionnaires, with a focus on complete data and covariates concerning female participants.
The analysis itself is well-documented, providing ample detail and incorporating interesting
covariates.
Some suggestions to improve the quality of the paper:
1. Weighted statistics were employed based on count data from each survey. However, it's
important to note that while weights effectively account for varying population sizes measured
concurrently, adjustments for temporal trends should be considered in this instance.
2. For Supplementary Figure 1 and accompanying text, it is recommended to include the area
under the curve for each plot to enhance the comprehensibility of the findings.
3. Regarding Table 2, a suggestion is made to incorporate the Odds Ratios (ORs) from BMI
alongside their corresponding 95% Confidence Intervals (CIs) for a more comprehensive
presentation of the data.
4. In relation to Table 3, it is advised to verify and correct the direction of the Odds Ratios (ORs)
associated with BRI (and BMI).
5. Concerning Table 4, it is requested that the authors include the Odds Ratios (ORs) from
BMI, accompanied by their respective 95% Confidence Intervals (CIs), to provide a more
comprehensive overview of the results.
Title: Abdominal obesity as assessed by anthropometric measures associates with urinary
incontinence in females: Findings from the National Health and Nutrition Examination Survey
2005-2018
Version: 2 Date: 31 Jan 2024
Reviewer's report:
Thanks for addressing the suggestions. You did a great job with all the calculations. Still, I
have a concern; now I can see all relations and the grade of precision.  The final conclusion of
using BMI as a simple measurement gives considerable error.  The AUC is above 0.6, and all
measurements are too close to each other.  Can you please give a rationale for your conclusion,
or if you decide to modify it?
Title: A Paradigm Shift in Cancer Research Based on Integrative Multi-Omics Approaches:
Glutaminase Serves as a Pioneering Cuproptosis-Related Gene in Pan-Cancer
Version: 0 Date: 21 Feb 2024
Reviewer's report:
The authors investigated the differential expression of GLS in various tissues and carcinomas,
performed enrichment analysis, and evaluated its clinical value. Additionally, they examined the
correlation between GLS and tumor immune infiltration, gene mutations, and drug sensitivity.
Through multiple omics analyses, they identified GLS as a promising molecular biomarker with
implications for metabolism and tumor immunology in pan-cancer. Moreover, they established
GLS as an effective and robust target specifically for uterine corpus endometrial carcinoma
(UCEC). Albeit, I consider these findings to provide new insight into cancer-related fields, I
still have some suggestions.
1, Most figures are highly professional; however, the authors should guide the readers to
the meaning of the images appropriately; otherwise, it will likely cause misunderstandings.
Therefore, I suggest the author consider revising these figures and legends again.
2, In Figure 1, the author presented the comparison of the expression level of the GLS gene
in tumors and normal tissues. Since the authors gave a general answer on gene expression,
is there any evidence of different roles in the cancer phenotypes of the above genes? Please
perform pertinent bioinformatic analyses and provide examples of studies investigating miRNA
alteration or DNA methylation (https://biit.cs.ut.ee/methsurv/) .
3, Since Connectivity Map (CMap) can be used to discover the mechanism of action of small
molecules, functionally annotate genetic variants of disease genes, and inform clinical trials. It
would be fascinating if the main data could be correlated with other clinical databases. Therefore,
I suggest the authors can validate their data via CMap, and discuss these methodologies and
literature in the manuscript  .
4, The author may need to use other statistical analyses, such as ANOVA to calculate the P-value
for three or more groups of data, and please update the “Statistical Analysis” of the Method
during further revision  .
5, There are few typo issues for the authors to pay attention to; please also unify the writing
of scientific terms. “Italic, capital”? Please double-check the superscripts and subscripts for the
whole manuscript.
6, Most references are out of date, the author needs to discuss the recent paper as well as the
analysis methods in this manuscript.
7, The font is too small for the current figures; meanwhile, the manuscript also needs English
proofreading.
Title: A Paradigm Shift in Cancer Research Based on Integrative Multi-Omics Approaches:
Glutaminase Serves as a Pioneering Cuproptosis-Related Gene in Pan-Cancer
Version: 0 Date: 21 Feb 2024
Reviewer:  Ankush Bansal
Reviewer's report:
Overall, this is a well-written and thorough manuscript investigating the role of GLS in pan-
cancer using bioinformatics analyses. The methods and analyses are sound.
The flow and organization of the manuscript are logical, moving from broad analyses to a
specific focus on UCEC.
Figures are clear, well-designed, and effectively support the results described in text.
Minor comments:
Line 163: Typo in "intro-cellular"
Line 302: Add space between values and parenthesis in "[gene biotype: protein-coding;"
Line 309: Typo in "clinic's"
Figure 9 legend: Fix typo in "clincal"
Some sentences are quite long and could be broken up to improve readability throughout the
manuscript.
Major comments:
Introduction:
The section focusing on mechanisms of cuproptosis is quite lengthy. Streamline this to 1-2
paragraphs briefly explaining cuproptosis and its link to GLS.
Elaborate more on previous research about the specific role of GLS in cancer - e.g. lines 132-135.
What types of cancers? What did those studies find about its mechanisms and functions? What
gaps remain?
Clearly state the purpose and rationale for your pan-cancer analysis of GLS early in the
introduction. Emphasize what new insights your comprehensive bioinformatics approach will
provide.
Discussion:
In the UCEC section, discuss the underlying biological significance of GLS being prognostic in
this cancer. What does this suggest about the metabolic or signaling pathways GLS is involved
in?
For the immune infiltration results, expand the discussion of the implications. For example,
you find GLS correlates with macrophages in TGCT - what might this relationship mean
functionally?
In describing limitations, be more self-critical regarding potential confounders or biases
in utilizing public databases and drawing links between expression and phenotypes/clinical
features. Validate experimentally.
Conclusion:
Highlight your 2-3 most exciting, impactful findings rather than broadly summarizing results.
This will leave the reader with key takeaways.
Elaborate significantly more about promising future directions - e.g. preclinical studies needed
to investigate mechanisms, potential to explore GLS as therapeutic target for specific cancers,
etc. Be creative and convincing in setting research agenda.
Title: A Paradigm Shift in Cancer Research Based on Integrative Multi-Omics Approaches:
Glutaminase Serves as a Pioneering Cuproptosis-Related Gene in Pan-Cancer
Version: 0 Date: 25 Feb 2024
Reviewer's report:
I read with great interest the manuscript, which falls within the aim of this Journal and offers
a high-quality overview of the topic.
The abstract perfectly summarizes the contents of the manuscript. The methodology is accurate
and conclusions are supported by the data analysis. The tables and figures are clear and
interesting.
Although the manuscript can be considered already of high quality, I would suggest taking into
account the following minor recommendations:
- I suggest another round of language revision, to correct a few typos and improve readability.
- I find it interesting to include a reference to the screening programs for early detections of
Cancer (Golia D'Augè T, Giannini A, Bogani G, Di Dio C, Laganà AS, Di Donato V, Salerno
MG, Caserta D, Chiantera V, Vizza E, Muzii L, D’Oria O. Prevention, Screening, Treatment and
Follow-Up of Gynecological Cancers: State of Art and Future Perspectives. Clin. Exp. Obstet.
Gynecol. 2023, 50(8), 160. https://doi.org/10.31083/j.ceog5008160).
-What do the results of this study add?
-What are the implications of these findings for clinical practice and/or further research? It is
important to report the results obtained by the authors in the context of clinical practice and to
adequately highlight what contribution this study adds to the literature already existing on the
topic and to future study perspectives.
- The authors have not adequately highlighted the strengths and limitations of their study. I
suggest better specifying these points.
Title: A Paradigm Shift in Cancer Research Based on Integrative Multi-Omics Approaches:
Glutaminase Serves as a Pioneering Cuproptosis-Related Gene in Pan-Cancer
Version: 0 Date: 26 Feb 2024
Reviewer's report:
This study is a valuable attempt to analyze the role of glutaminase (GLS) in cancer from multiple
perspectives and to identify its potential as a biomarker for diagnosis and prognosis, especially
in uterine cancer (UCEC). However, it would be even better if improvements were made in the
following areas
Sample size and diversity of the data set:
This study utilizes existing databases such as UCSC Xena, HPA, and CCLE, but lacks a detailed
discussion of sample size variation in these data sets and the representativeness of samples
with different demographic characteristics for each cancer type. In particular, an explanation of
samples from populations with different ethnic backgrounds and diagnostic criteria is warranted.
Statistical methods:
While a wide variety of statistical methods were used in this study, a more detailed description
of the selection criteria for the statistical models used, particularly the selection and treatment
of covariates in multivariate analyses and whether multiple comparison correction was
appropriately applied during statistical testing, would be helpful.
Verification of functionality as a biomarker:
To conclude that GLS is a promising biomarker for cancer treatment, it is necessary to examine
or discuss the functional role of GLS and how GLS-targeted therapies may benefit cancer
treatment. In particular, detailed studies of how GLS suppression or overexpression affects
UCEC cell proliferation, survival, and drug sensitivity are needed.
Interactions between genetic heterogeneity and the tumor microenvironment:
While the data on the correlation of GLS expression with tumor immune invasion is interesting,
its interaction with genetic heterogeneity is unclear; a more objective discussion of the
mechanisms by which changes in GLS expression act on the tumor microenvironment and affect
immune responses is needed.
Correlation analysis with genetic heterogeneity:
Although GLS is proposed as a biomarker for UCEC, more detailed data on the relationship
between GLS expression levels and patient response to therapy, incidence of side effects, and
survival is needed to discuss its clinical application.
Title: A Paradigm Shift in Cancer Research Based on Integrative Multi-Omics Approaches:
Glutaminase Serves as a Pioneering Cuproptosis-Related Gene in Pan-Cancer
Version: 1 Date: 23 Mar 2024
Reviewer's report:
Thank you for going through the manuscript and the reviewers' points
In my honest opinion, the authors have responded satisfactorily to the reviewers’ criticisms.
The manuscript is well written and falls within the aim of this Journal.
Title: A rare case of fundal intramural ectopic pregnancy associated with previous B-Lynch
sutures
Version: 2 Date: 22 Dec 2023
Reviewer:  Susan Abed Zaidan
Reviewer's report:
An interesting case report, well written, and satisfactorily managed. Only two points need
clarification:
Line 46-50 : MRI showed cystic structure with thickened myometrium and the sentence repeated
about a cystic structure but the local myometrium was significantly thinned. Is it the same cyst?
Is it from another plaine ?
Line 89-90 : I think it is worth to mention that it could be B-lynch suture could be incidental in
this case and not the cause of this ectopic pregnancy
Title: A rare case of fundal intramural ectopic pregnancy associated with previous B-Lynch
sutures
Version: 5 Date: 18 Jan 2024
Reviewer's report:
Dear Authors,
Thank you for submitting your insightful case report on the rare occurrence of intramural ectopic
pregnancy associated with B-Lynch sutures. The unique nature of this case and the challenges it
presents in diagnosis and management make it a valuable contribution to the medical literature.
I appreciate the clarity in presenting the case details, diagnostic procedures, and surgical
intervention. Your comprehensive discussion on the etiology, pathogenesis, and diagnostic
challenges of intramural pregnancy adds significant value to the overall narrative.
However, I would like to offer some constructive notes to enhance the quality of your paper
further:
1. Abstract:
- Consider incorporating information about the successful outcome post-surgery and the patient's
follow-up status to provide a more comprehensive abstract.
2. Introduction:
- Enhance the introduction by explicitly stating the significance of the case within the broader
medical context for greater context and relevance.
3. Case Presentation:
- Improve the structure of the description of the surgical procedure to enhance clarity and
understanding.
- Include details on postoperative recovery and the patient's current status to complete the case
presentation.
4. Discussion:
- Add a more detailed discussion on the potential impact of the case on future fertility to enrich
the analysis.
- Provide explicit recommendations for gynecologists managing similar cases to enhance
practical insights in the discussion.
5. References:
- Adjust the reference format to follow a standardized style, such as AMA or APA, for
consistency.
I believe these refinements will strengthen your paper and provide a more comprehensive
and insightful resource for the medical community. I appreciate your dedication to advancing
medical knowledge and look forward to the revised version of your valuable contribution.
Best regards,
Title: Midwives’ lived experiences of caring for women with mobility disabilities during
pregnancy, labour and puerperium in Eswatini: A qualitative study
Version: 1 Date: 28 Dec 2023
Reviewer's report:
It's a well written paper, the authors mention that an independent coder  also coded the interviews
separately. Did they  calculate the inter coder reliability if so what was the percentage?
Data sharing is not clear as authors have declared that there is no data yet this was a qualitative
study where data was collected and analysed. Can the authors confirm that they've the data they
're presenting and they   are willing to share the data if requested.
I  am recommending the paper to be published after addressing the above concerns.
Title: Midwives’ lived experiences of caring for women with mobility disabilities during
pregnancy, labour and puerperium in Eswatini: A qualitative study
Version: 1 Date: 04 Jan 2024
Reviewer's report:
The article title 'Midwives' lived experiences of caring for women with mobility disability during
pregnancy, labor and puerperium in Eswatini:  A qualitative study' focused on physical health
and wellbeing of women' to ensure quality care for disabled women during labor and delivery.
The article is well written. Qualitative, explorative and descriptive phenomenological approach
is appropriate as the researchers needed to explore the experiences of midwives in caring for
women with mobility disabilities. Purposive sampling, interviews and Giorgi et al five steps of
data analysis were employed and appropriate for the chosen research design.
The article   can be improved by addressing the following aspects:
- The word 'regions' can be included in the title as the research was not done in the whole country.
- The background to include statistics of women with disability for the selected regions if
available.
- The aim of the study to align with the title.
- The number and type of maternal health facilities and public health units to be indicated.
- Table 1 to have information on public health units and hospitals.
- Authors to indicate if written consent was obtained.
- Authors to indicate if the question was pre-tested.
- Type of interviews to be indicated.
- Brief description on how ethical principles were ensured to be included.
- Mobility challenges during pregnancy  and puerperium not clearly indicated from quotes.
- Themes and categories to be named as indicated on Table 2.
- A table with demographic characteristics of participants or description thereof could have been
included.
Title: Midwives’ lived experiences of caring for women with mobility disabilities during
pregnancy, labour and puerperium in Eswatini: A qualitative study
Version: 4 Date: 16 Feb 2024
Reviewer's report:
I have reviewed all the comments and still have the following questions:
(i) Not sure why P is included in the table on page 8?
(ii) Just to clarify pre-testing of the tool was only conducted on one person. Was the tool piloted
before?
(iii) An ICR of 100% is rare, does this mean that both coders coded all the excerpts the same?
Title: Rate and risk factors of inadequate endometrial tissues after endometrial sampling among
Bhutanese women at the national referral hospital of Bhutan: a cross-sectional study.
Version: 1 Date: 03 Feb 2024
Reviewer's report:
This is an interesting area for research and the authors have done a good literature review for
the introduction section and justification.
The methodology is explained in detail with the data collection procedure.
Table 2 in the univariate analysis and lines 213 -215 states there was an increased risk. However,
since the confidence interval goes through one can you actually make that conclusion? Better to
mention although the OR  is greater than 1, the CI does not state it is significant
Line 256 -258 also mentions the same in the discussion section.
Can the authors say that cross sectional study design as a strength? The limitations are well
addressed.
references - please check whether DOI is mentioned in the reference list
Title: Rate and risk factors of inadequate endometrial tissues after endometrial sampling among
Bhutanese women at the national referral hospital of Bhutan: a cross-sectional study.
Version: 1 Date: 07 Feb 2024
Reviewer's report:
Method:
Please detail how was the sample size calculated?
line 247 - should indicate that this was  finding from previous study
line 273-  is there anymore data about other type of endometrial sampling device? pls state t
why do you think the reason for discrepancy.
Title: Health Related Quality of Life and its predictive factors on cervical cancer patients in two
teaching hospitals, Addis Ababa, Ethiopia
Version: 2 Date: 20 Jul 2023
Reviewer:  Irene iavarone
Reviewer's report:
I read with great interest the present Manuscript which falls within the aim of the Journal. In my
honest opinion, the topic is interesting enough to attract the readers’ attention. Methodology is
accurate and conclusions are supported by the data analysis. Nevertheless, authors should clarify
some points and improve the discussion citing relevant and novel key articles about the topic.
For all those reasons, I suggested performing the minor revisions.
-Regarding exclusion criteria in Methods, Authors should clarify which are the “severe medical
conditions” mentioned in the paragraph;
-in Discussion, Authors could explain whether predictive factors in cervical cancer are related
to specific biomarkers, similarly to other contexts like endometrial cancer. Please consider:
“Ronsini C, Fumiento P, Iavarone I, Greco PF, Cobellis L, De Franciscis P. Liquid Biopsy in
Endometriosis: A Systematic Review. Int J Mol Sci. 2023;24(7):6116. Published 2023 Mar 24.
doi:10.3390/ijms24076116”;
-in Discussion, Authors may clarify whether fertility-sparing options in cervical cancer can
improve health-related QoL response, also similarly to other contexts like endometrial cancer.
Please consider: “Ronsini C, Mosca L, Iavarone I, et al. Oncological outcomes in fertility-sparing
treatment in stage IA-G2 endometrial cancer. Front Oncol. 2022;12:965029. Published 2022
Sep 16. doi:10.3389/fonc.2022.965029”
and “Ronsini C, Solazzo MC, Bizzarri N, et al. Fertility-Sparing Treatment for Early-
Stage Cervical Cancer # 2 cm: A Problem with a Thousand Nuances-A Systematic
Review of Oncological Outcomes. Ann Surg Oncol. 2022;29(13):8346-8358. doi:10.1245/
s10434-022-12436-w”;
-in Discussion, Authors may explain whether gut microbial composition in patients with cervical
cancer may reflect on a different perception of symptoms, similarly to other contexts like
endometriosis. Please consider: “Iavarone I, Greco PF, La Verde M, et al. Correlations between
Gut Microbial Composition, Pathophysiological and Surgical Aspects in Endometriosis: A
Review of the Literature. Medicina (Kaunas). 2023;59(2):347. Published 2023 Feb 12.
doi:10.3390/medicina59020347”;
-the Authors have not adequately highlighted the strength of the study. I suggest better specifying
that point.
Title: Health Related Quality of Life and its predictive factors on cervical cancer patients in two
teaching hospitals, Addis Ababa, Ethiopia
Version: 2 Date: 22 Aug 2023
Reviewer's report:
For Authors.
1. Can you change the title to "Quality of life and associated factors among cervical cancer
patients at teaching hospitals in Addis Abeba, Ethiopia" if you like, or does it not matter?
2. How do you see its originality in light of a similar study being undertaken at Tiker anbessa
Hospital? Do you have any variables that make your article stand out?
3. Could you include the study's objectives in the abstract section, either in the introduction or
separately?
4. What is your outcome variable? (Is it Global health status or quality of life)? Because you
have to use similar terms across your paper.
5. Abbreviation is generally not advised as a key word and should be done in accordance with
MeSH terms.
6. 6. It is preferable if you include one extra paragraph in the introductory section about the gap,
particularly in your study topic.
7. Could you add number of Health care providers on the study area?
8. Operationalized the QOL, based how you was used in analysis.
9. How did you get the sample size?
10. Why did you used Anova for analysis
Title: Determinants of self-rated health among highly educated Ukrainian women refugees in
Czechia: analysis based on cross-sectional study in 2022
Version: 0 Date: 16 Dec 2023
Reviewer:  Tomasz Michalski
Reviewer's report:
The article is very interesting and worth publishing. In fact, there are very few scientific articles
devoted to this question. I find it particularly valuable to examine the role of the geographic
context of the place of origin in Ukraine on self-assessment of health status. I also have
no reservations about the survey sampling technique. Summary: I recommend the article for
publication without any corrections.