Reviewer’s report
Title: 
Practice Patterns  of  Adjuvant Radiotherapy in Women with Stage I to II
Endometrial Carcinoma: A Real-World  Multi-Institutional  Analysis  in  China
Version: 
1 
Date: 
30 May 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS: 
OBJECTIVE - Full research articles: is there a clear objective that addresses a
testable research question(s) (brief or other article types: is there a clear
objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols)
appropriate for the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor
to allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results
reasonable and not overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work
technically sound? If not, can revisions be made to make the work technically
sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS: 
GENERAL COMMENTS: Authors aim to evaluate change in the trend of
radiotherapy modality in the adjuvant setting of endometrial cancer. They
included a significant number of patients who had been treated between 
2003
and 2017. They clearly showed that deintensification strategy, which
significantly decreased the acute and long-term toxicity, in the adjuvant
radiotherapy of the endometrial cancer. 
Most of the patients treated with VBRT
only and EBRT mostly used only in the high-risk patients. Though this
information did not add significant changes in daily practice, it is a good
example of practice change in the adjuvant treatment of endometrial cancer.
Major findings of the current study demonstrate that deintensification strategy in
the adjuvant radiotherapy of the endometrial cancer significantly decreases
morbidity without decreasing effectiveness. 
No novel method was used. No
hypothesis generating information was generated.
Declaration of competing interests
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organization that holds or has applied for patents relating to the content of
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Do you have any other financial competing interests?
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Do you have any non-financial competing interests in relation to this
paper?
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interests' below. If your reply is yes to any, please give details below.
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recommendation.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
No
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes
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No