Reviewer’s report
Title: 
Early Onset, Multiple, Bilateral Fibroadenomas of the Breast: A Case
Report
Version: 
0 
Date: 
13 Feb 2021
Reviewer's report:
A case report of early onset of multiple FA and PTEN mutation.
1. In page 3 line 3-4, authors wrote "These fibroadenomas are more likely to be
complex and hyalinize at an early age". In previous report (ref 4), "Fibrosis is a
significant characteristic of the breasts of patients with CS. Fibroadenomas
appear to hyalinize at an early age and are frequently complex. The specimens
demonstrate a spectrum of dense hyalinization of both the lobule and the stroma,
and hyaline nodules appear to be the most characteristic lesion." Does this
patient have any special pathological characteristics of fibroadenoma by needle
biopsy? Give pathological images of needle biopsy.
2. In page 4 line 9 - 10, what kind of genetic testing was performed? Germline
mutational panel test or just for PTEN? If so, why did you choose PTEN? This
patient did not meet criteria for testing under NCCN guideline.
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