Reviewer’s report
Title: 
Applicability of polygenic risk scores in endometriosis clinical
presentation
Version: 
3 
Date: 
11 Mar 2022
Reviewer's report:
I read with great interest the manuscript, which falls within the aim of this
Journal. In my honest opinion, the topic is interesting enough to attract the
readers' attention. Nevertheless, authors should clarify some points and improve
the discussion, as suggested below.
Authors should consider the following recommendations:
- Manuscript should be further revised in order to correct some typos and
improve style.
- Accumulating evidence suggests that immune cells, adhesion molecules,
extracellular matrix metalloproteinase and pro-inflammatory cytokines
activate/alter peritoneal microenvironment, creating the conditions for
differentiation, adhesion, proliferation and survival of ectopic endometrial cells. I
would discuss these points in the light of new theories about the pathogenesis of
endometriosis, referring to: PMID: 31663401; PMID: 28100109.
- I would suggest to discuss, at least briefly, novel pieces of evidence about the
effects of FSHR and FSHB variants on hormonal profile and reproductive
outcomes of infertile women affected by endometriosis (PMID: 34659133).
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
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Yes
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from apparent manipulation?
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