JerMa88/BMC_Womens_Health_Peer_Reviews huggingface dataset:
Title: Women’s experiences of using patient portals in healthcare settings: A rapid review
Version: 1 Date: 23 Jun 2024
Reviewer's report:
General Comments
=================
This paper reports a rapid review on the experiences of women using patient portals across
healthcare settings to get a broad overview. It focused particularly on the implications of the
findings in the context of mental health. Understanding the experience of women, within mental
health, was well justified by the gender-based differences in mental health prevalence and
challenges with accessing care. The recognition of women of varying identities is appropriately
inclusive. The authors followed the Cochrane rapid review methodology and included grey
literature. They describe the barriers and facilitators of portal use and apply the findings to
accessing portals for mental health.
Overall, the manuscript is well written. Opportunities for improving clarity on categorization of
the findings and improving the alignment of the results and discussion sections per the comments
below.
Specific Comments
1. It would be helpful to have the search strategies provided in an additional file.
2. The details on organizing the categories of barriers and facilitators are sparse. It would be
helpful to have an overview of the categories, perhaps in a text box or opening sentence.
3. Section 4.3 –“These researchers also discovered how having public versus private health
insurance was a barrier to accessing the patient portal (27).” Does this mean public health
insurance had lower use than private? [this may be interesting to explore in the discussion
given the healthcare system structure in US vs Canada/other publicly funded countries…this is
indirectly referred to in the limitations]
4. Section 4.4 as described, the studies were not focused on mental health and the interpretation
may be better suited for the discussion.
5. Looking at section 4.4 and the first paragraph of the discussion, there seems to be a category
or theme of clinical/patient-reported benefits. Did you consider looking at the data from this
viewpoint, essentially as facilitators? E.g., including details on breastfeeding rates and HIV viral
loads which are mentioned in the discussion. This could be moot if there were more details on
the categorization of findings that describes how the articles in 4.4 were identified vs the articles
with other user outcomes.
6. There are some instances where the discussion of the results includes details that are not in
the results, so they do not align well. E.g., Starting on line 287, health equity and literacy are
mentioned, but these were not mentioned in the results section.
7. What are principles of feminist intersectionality that could be applied to design of digital
interventions? Can you give some examples?
Minor Comments
1. line  215 -square brackets on reference 41
2. Section 4.2 -is the first facilitator gender? (lines 230-232)
3. Section 4.3 -re: age. Can you elucidate if the trends were higher use among older vs younger
(or the flipside)
Title: Women’s experiences of using patient portals in healthcare settings: A rapid review
Version: 1 Date: 26 Jun 2024
Reviewer's report:
Thank you for submitting your review study on women's experiences of using patient portals.
The paper covers such an important topic that future studies on women's health can refer to. I
have several comments that you may want to consider.
Major comments
1. Since studies included in your review are not limited to mental health context, I suggest you
to revise the paper more broadly, not limited to mental health care.
2. In the Results, sections are not written clearly. For example,  on page 12 line 230, "In two
studies, researchers discovered that women exhibited higher levels of engagement with the
patient portal compared to men..." What is the facilitator, being a woman? The '4.2 Facilitators
of patient portal use' sounds more like benefits of using patient portals, and '4.3 Access barriers'
section is mixed of associated factors of patient portal use and barriers. The '4.4 Mental health
challenges' section does not describe any challenges, but rather describes perceived benefits of
using patient portals.
Minor comments
1. Provide the review period (meaning when the review was conducted).
2. What is your rationale for including non-binary/gender diverse when your topic is about
women's health?
Please also revise the Abstract, Background, and Discussion accordingly.
Thank you.
Title: Women’s experiences of using patient portals in healthcare settings: A rapid review
Version: 2 Date: 11 Jul 2024
Reviewer's report:
The authors have edited their paper, providing more clarity in the methods about categorization
of their results. Overall the edits to the paper have improved the manuscript.
A few additional comments:
In the abstract, the authors have edited their objectives to the following: 1. to discover pertinent
facilitators for women when using patient portals, 2. to discern if women face individual barriers
to accessing patient portals, and 3. to recognize if use of patient portals has applications to
women's mental health care.
The word ‘recognize’ is hard to quantify or qualify. The authors may more appropriately have
“explored the potential role of patient portals for women’s mental health care.”
The addition of the search strategy is helpful but the brackets are difficult to understand.  For
example, “woman OR women (subject heading female) OR trans OR transgender OR non-binary
AND patient portal” Are all of the gender terms or’ed together and then ‘and’ with patient portal?
Also for MEDLINE, the search appears to group (portal and women) OR transgender OR non-
binary. Which means transgender and nonbinary were searched without confining to ‘portal’.
Please edit so that a reader could replicate your search strategy.
Minor:
Lines 263-4 in the tracked change document reads: ). “Being actively engaged with the patient
portal was critical for women to actively utilize their its functions (31,37).” Change ‘their’ to
‘portal’
Title: Women’s experiences of using patient portals in healthcare settings: A rapid review
Version: 2 Date: 21 Jul 2024
Reviewer's report:
I appreciate your revisions based on my comments. I see the manuscript has been improved.
However, I still think that you do not need to separate out 'mental health' throughout the
manuscript, from Background to Conclusion. Your review results can be discussed in the context
of women's health.
Minor comments: I understand your rationale for including non-binary/gender diverse who are
assigned the sex of female at birth. Please clarify this in the section 3.2 Inclusion criteria.
Title: Association of Serum Homocysteine with Vitamin B12 and folate levels in women with
Pre- eclampsia in a tertiary health care center in Nepal
Version: 1 Date: 31 Oct 2023
Reviewer's report:
1. Pre-eclampsia needs to be defined precisely in the Introduction, along with how it varies from
gestational hypertension.
2. What distinguishes this study from a plethora of previous cross-sectional case studies that
produced comparable results?
3. What can this research add to the body of knowledge already in existence?
4. The study would have been more robust if it had included pregnant women without pre-
eclampsia in comparison.
5. Were these pregnant ladies given vitamins B12 and folic acid when it was determined that
they were deficient in those nutrients? Regarding hyperhomocysteinemia, what was done?
Title: Association of Serum Homocysteine with Vitamin B12 and folate levels in women with
Pre- eclampsia in a tertiary health care center in Nepal
Version: 1 Date: 02 Jan 2024
Reviewer's report:
The research question taken up in this study is  well conceived  with the possible  Clinical
applications   The following points may be incorporated for the  clarity  of the data and research
findings.
1. The title is appropriate and the content lies within the scope of the Journal.
2. The  selection of the study subjects should have made more explicit with the valid inclusion
and exclusion criteria.
3. The sampling method and sample size calculation should have been incorporated so as to
justify the strengh and poer to the study.
4. All the methodology and results section should be  written in the past tense.
5. Since  median values of the parameters under study (as shown in Table 1) has been stated
along side the mean values and SD, the IQR  need to be given with the median values.
6. Since the study only considers the preeclamptic patients under study for the assessment of
Biochemical parameters, it is not clear if or not the normal pregnant women will have depleted
folic acid, Vitamin B12 and elevated  homocysteine level. This should find importance in
discussion to support the  possible outcome of these alteration in preeclampsia.
7. The  study cannot have the statistical power and evidence to predict  as stated in the conclusion
but may help in patient's management.
Title: Association of Serum Homocysteine with Vitamin B12 and folate levels in women with
Pre- eclampsia in a tertiary health care center in Nepal
Version: 2 Date: 04 Mar 2024
Reviewer's report:
1.  Most of the queries pointed previously have been addressed and now it appears better .
2. The results  in the  abstract should be presented in the in the past tense which needs to be
corrected.
3. Write the inclusion/ Exclusion criteria in sentence form.
4. The interquartile range and CI of the median is to be presented in correct form.
Rest is ok.
Title: Association of Serum Homocysteine with Vitamin B12 and folate levels in women with
Pre- eclampsia in a tertiary health care center in Nepal
Version: 4 Date: 21 May 2024
Reviewer's report:
Kindly address the following concerns:
a. In Table 2; Pre-eclampsia has been categorized into mild and severe; you need to clarify why
the moderate category has been excluded. Also, state the cut-off values for these categories.
b. Kindly state the limitations and strengths of this study. What makes this study more unique
than similar studies conducted previously?
Title: Association of Serum Homocysteine with Vitamin B12 and folate levels in women with
Pre- eclampsia in a tertiary health care center in Nepal
Version: 4 Date: 27 May 2024
Reviewer's report:
Thank you for submitting your revised  and corrected manuscript. It is a good study and the
results are quite interesting . However,  as included in the conclusion, the results may not be
able to predict the severity as per the statistical tools used.
Title: Associations of luteal phase changes in vagally mediated heart rate variability with
premenstrual emotional changes
Version: 3 Date: 14 Mar 2024
Reviewer's report:
The authors have made a thorough and conscientious effort to address all my initial concerns.
I appreciate the care and thoughtfulness with which the authors have revised their manuscript.
The result is a paper that more clearly and coherently conveys the crucial aspects of the paper:
the method, results, and conclusions derived from those results. As such, I request no further
changes to the manuscript.
.
Title: Relationship Between Triglyceride-Glucose Index and Endometriosis: A Cross-Sectional
Analysis
Version: 0 Date: 06 Jul 2024
Reviewer's report:
I had the pleasure of reviewing this cross-sectional analysis on a very interesting topic related
to endometriosis. The work is well-written, but I have some revisions to suggest:
1. Abstract: Add a reference on the association between endometriosis and gestational diabetes
to strengthen the background of the study (doi: 10.1038/s41598-023-35236-y).
2. Diagnosis of Endometriosis: Provide more details about the assessment, including
questionnaires or records evaluated. Was the diagnosis surgical? By imaging?
3. Evaluation of TyG Index: Remove the colon (”:”) from the title. Provide the formula adopted.
4. Covariates: Add a reference on how the PIR was calculated.
5. Statistical Analysis:
a. Report continuous variables as means (Standard deviations), possibly adding also Standard
errors.
b. Provide more details on how PSM was performed, including the variables included in the
matching process.
6. Limitations: Add recall bias as a major limitation of the study due to the mode of assessment.
7. Conclusions: Discuss how these findings can impact clinical practice.
Title: Relationship Between Triglyceride-Glucose Index and Endometriosis: A Cross-Sectional
Analysis
Version: 0 Date: 08 Jul 2024
Reviewer:  Burak Sezgin
Reviewer's report:
Dear Editor
Many thanx to give me the opportunity to review tha article entitled ‘Relationship Between
Triglyceride-Glucose Index and Endometriosis: A Cross-Sectional Analysis.
The authors present a link between insulin resistance and endometriosis. Although it is difficult
to make a recommendation because of the self report diagnosis of endometriosis, the study
contributes to the literature because they summarize the literature and revealed that an elevated
TyG index is linked to an increased incidence of endometriosis. This finding has a value.
Advices to authors
The authors represented that RCS curves indicated that the risk of endometriosis increases
notably when the TyG index exceeds 8.51. At the conclusion section they adviced that
proactive management of blood glucose and lipid levels might help reduce the prevalence of
endometriosis. At this point I want to ask authors if the blood glucose and lipid levels of
the patients is at the normal ranges but the index is above 8.51, will they advice proactive
management?
Title: Relationship Between Triglyceride-Glucose Index and Endometriosis: A Cross-Sectional
Analysis
Version: 2 Date: 18 Jul 2024
Reviewer's report:
1. Background
Line 71: Lack of effective diagnostic methods
This statement is inappropriate. The detection rate of endometriosis through vaginal ultrasound
is relatively high, but very early endometriosis cannot be detected in a timely manner. Therefore,
there is a lack of effective early diagnostic methods
2. Format
Tables and icons should be arranged according to the content of the article and should not be
placed at the end of the manuscript
3. Exclusion criteria
The etiology of endometriosis is not yet clear, for example, menstrual blood reflux may lead to
endometriosis. However, this manuscript selected the triglyceride glucose index as an indicator
to explore the intrinsic relationship between endometriosis and this index. Therefore, whether the
research subjects should exclude women who have been pregnant before is to exclude potential
influencing factors
Title: Pseudo-Meigs syndrome caused by a rapidly enlarging hydropic leiomyoma with elevated
CA125 levels mimicking ovarian malignancy: A case report and literature review.
Version: 1 Date: 04 Mar 2024
Reviewer's report:
1. This article should be checked by a mother-tongue scientist. For example, in Case report,
there are contrary descriptions about tumor boundaries. “Specialized examination found a giant
solid mass located on the right side of the lower abdomen with clear boundaries, and no other
abnormalities were found. The giant mass filled the pelvic cavity with obvious tenderness
to palpation. An abdominopelvic computed tomography (CT) scan showed a large, well-
circumscribed cystic-solid mass located in the pelvic cavity, measuring 14.7x11.3x12.7cm in
size, with a large mount of ascites (Figure 1, 2). The boundary of the mass is unclear near the
posterior uterine wall.” In addition, there are too many spelling errors in the article.
2. The follow-up period of this patient disclosed different timing in sections of abstract, and case
report. In abstract section, the description of follow-up period is “Follow-up was obtained at 6
months, 1 year, and 2 years after surgery, respectively.”. In case report section, the description
of follow-up period is “Follow-up was conducted at 40 days, 6 months, and 12 months after
surgery, respectively.”.
3. This article is similar to the article reported by Mohamed Abdelgawad et al. in 2022,
“Large uterine leiomyoma presenting as pseudo-Meigs' syndrome with an elevated ca125: a
case report and literature review. J Surg Case Rep 2022 Jun 7;2022(6):rjac253.” Compared with
that reported by Mohamed Abdelgawad, there are some drawbacks of this this article, such as
redundant sentences of pathogenesis of hydropic uterine fibroid in the discussion section, and
many spelling errors.
4. In table 1, the first line, “Uterine myomata treated with GNot reportedH agonist.” should be
“Uterine myomata treated with GNRH agonist.”.
Title: Immune-related Gene Signature Improves Prognosis Prediction in Patients with Breast
Cancer and Associates it with Tumor Immunity and Inflammatory Response
Version: 3 Date: 13 Jun 2024
Reviewer's report:
In this manuscript, Zhang et al., have been developing an immune score (IS) indicator based on
the immune checkpoint inhibitor-related mRNAs and long non-coding RNAs (lncRNAs). With
this immune score, they predict prognosis of breast cancer patients with significant difference.
Generally, I support this work for publication, but there are still several questions need to be
addressed.
1. The key design, in my opinion, of this paper is the calculation method of immune score,
which is the sum of coefficient times expression level of significant prognostic genes. The
straight drawbacks might be the different expression level of genes. Could the gene with higher
expression level will contribute a higher coefficient in IS? Or the likely influence of genes
with lower expression vice versa. Authors should clearly show the genes contributions in IS.
Furthermore, if the immune score is a robust indicator in different datasets?
2. In this work, datasets are generated different platform (like microarray and sequencer), so
a more comprehensive details on how those datasets were integrated is needed. Specifically,
explain the normalization methods and any batch effect corrections applied to ensure consistency
across datasets.
3. In general, interpretability of figures needs to be enhanced with labels. For example, Figures
2B, 2D, and 3B, 3D all looks very similar and without digging into the figure legend it is difficult
to tell what is different about them. Adding graph titles with significantly help with this.
4. In section 3.3, "Different Immune-related Features Between Low- and High-Score Patients,"
elaborate on the implications of the findings related to immune checkpoint molecules (CTLA4,
PD-1, PD-L1) in the context of breast cancer immunotherapy, this needs to be discussed, if not
compared as part of the Background.
Title: Immune-related Gene Signature Improves Prognosis Prediction in Patients with Breast
Cancer and Associates it with Tumor Immunity and Inflammatory Response
Version: 4 Date: 17 Jul 2024
Reviewer's report:
Thank you for the response. The added explanation in METHODS section  gives  clearer
messages on normalization between datasets. Revised DISCUSSION provides us a profound
view on the biological significance of the immune-related genes in breast cancer. I support this
work for publication.
Title: Effects of Whole-Body Vibration on Bone Mineral Density in Postmenopausal Women:
An Overview of Systematic Reviews
Version: 2 Date: 12 Jul 2024
Reviewer's report:
Hi,
Congratulations on your study, consider that it leaves relevant information but I offer you some
comments. I ask you to answer the following specific questions about the manuscript and provide
additional suggestions where appropriate.
1. My main doubt and concern is that you take into account the BMD gain at all times, but as
you say in the introduction, BMD is lost with age, therefore it is beneficial to gain that BMD
with exercises, such as not loss, therefore, why do you not refer to the constant maintenance of
BMD or the non-loss of BMD, as an objective of treatment for vibrations?
3. On line 110  Search strategy "from the beginning to July 31, 2023" Because you have not
specified dates, since when you started extracting articles, explain it better
2. On line 369: 3.5 SR author's opinion
You say that on line 369: 3.5 SR author's opinion
" the authors of nine SRs believed that WBV may be effective in improving bone density in
postmenopausal women, four conclusions maintained a neutral stance, stating that the current
quality of evidence is poor, making it difficult to provide a definitive answer. Two conclusions
considered WBV to be ineffective",
but the conclusions do not go along those lines, explain better
Title: Empowering Mind-Body Wellness: Effect of Bundling Seated Exercises and
Psychoeducational Rehabilitation Using the Teach-Back Approach on Fatigue and Coping of
Women Postmastectomy
Version: 6 Date: 05 May 2024
Reviewer:  Kamil Fram
Reviewer's report:
Dear Authors;
Thank you for your interesting subject, which may have a front place shortly for the management
of breast cancer.
Unfortunately, three important comments should be taken into consideration before publication:
1. The manuscript contains grammar, punctuation, and grammatical errors.
2. There are a lot of copy-paste ideas and sentences, which is unacceptable.
3. The main point is how to document references, as I am confused between digital
numbering documentation after the citation, which is used in some scientific journals, or using
documentation by mentioning the author and year of publication after the citation, in addition
to the loss of many references, such as reference No. 6.
This research needs a careful review of all its parts
Title: Empowering Mind-Body Wellness: Effect of Bundling Seated Exercises and
Psychoeducational Rehabilitation Using the Teach-Back Approach on Fatigue and Coping of
Women Postmastectomy
Version: 6 Date: 08 May 2024
Reviewer:  Li-Hong Qiu
Reviewer's report:
Dear Authors,
Thanks for your efforts.
The revised manuscript was improved. Some minor issues should be addressed.
1. Font size should be standardized. In the Abstract, the size of "p" was smaller than other words.
2. The format of references should be standardized.
3. I would recommend that you continue to follow these patients to observe the oncologic
outcomes of these patients.
4. The entire text is recommended to be proofread carefully.
Title: Empowering Mind-Body Wellness: Effect of Bundling Seated Exercises and
Psychoeducational Rehabilitation Using the Teach-Back Approach on Fatigue and Coping of
Women Postmastectomy
Version: 8 Date: 28 Jun 2024
Reviewer:  Ali Mansoor AlAmeri
Reviewer's report:
Dear Author
You have done great job by considering qualitative research in clinical field, namely
rehabilitation of cancer patient. Using such intervention comparative cohorts with excilent
content analyses of the study data aids in achievement of study outcomes. One note regarding
relatively  small sample size, which need to be referred to in the study challenges. All the best
for success.
Ali Mansoor
Title: Empowering Mind-Body Wellness: Effect of Bundling Seated Exercises and
Psychoeducational Rehabilitation Using the Teach-Back Approach on Fatigue and Coping of
Women Postmastectomy
Version: 8 Date: 01 Jul 2024
Reviewer's report:
Dear Authors;
Thank you for your interesting subject;
I read with much interest your procedure and I have limited comments for your manuscript. The
post mastctomy period for the woman is a period of high psychological vulnerability. So your
study seems to me to be well conducted and responsive to the research question.
Respectfully.