Reviewer’s report
Title: 
Relationship between vitamin D receptor gene polymorphisms (BsmI,
TaqI, ApaI, and FokI) and calcium intake on bone mass in young Japanese
women
Version: 
0 
Date: 
04 Jan 2021
Reviewer's report:
This manuscript describes the effect of several vitamin D polymorphisms and
dietary factors on bone mass in young Japanese women. 
On line 134 the statement "A significant difference in OSI was observed among
the BsmI and TaqI genotypes after adjusting for covariates (BMI; p = 0.030 and
0.019,respectively)." Is BMI the only covariate? 
If so, the statement should not
state that there were covariates. 
If there were other covariates, these should be
mentioned.
Calcium intake, estimated from dietary records, is given as mg calcium/kcal
dietary energy. 
What is the justification for using this ratio rather than just mg
calcium. 
No rationale is given and no references are cited for this. 
Table 2 should show the number of observations for each comparison. 
In Tables 3 and 4 the SD of the homozygous minor genotype for BsmI and for
TaqI, calculated from the N and SE in the Table, are less than half the variation
of the other genotypes. 
The low variability results in significant differences
between high and low calcium intake groups. An explanation for the low
variability in the homozygous minor genotype is essential.
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