Reviewer ’s report  
 
Title:  Growth Pattern of Uterine Leiomyoma Along Pregnancy  
 
Version: 0 Date: 23 Jun 2019 
 
Reviewer:  Ibrahim  A. 
 
Reviewer’s report:  
 
Dear Respectable Editors  
 
Good Day  
 
Thank you very much to give me the opportunity to review the manuscript entitled (Growth 
Pattern of Uterine Leiomyoma Along Pregnancy).  
 
Its very interesting article with structured abstract and informat ive title.  
 
References as cited correctly and relevant to the article.  
 
The aim of the study was to evaluate rate of uterine leiomyoma growth in the 3 trimesters of 
pregnancy.   
 
Two-hundred forty -eight uterine leiomyomas were included in the study.  
 
The aut hors found that the leiomyoma area increased substantially in size between the 1st and 
2nd trimesters (54.5%±75.9%, p=.007) and to a lesser degree between the 2nd and 3rd trimesters 
(17.9%±59.7%, NS). Evaluation of the change in size throughout the pregnan cy between 1st and 
3rd trimesters revealed a significant increase of 95.9%±191.3% (p<.001). There was no 
significant growth of the leiomyomas between the 2nd and 3rd trimesters.  
 
The authors concluded that uterine leiomyomas tend to grow substantially d uring the first 
trimester of pregnancy. This trend is attenuated later with minimal growth towards the end of 
gestation.  
 
Please, see the attached PDF file, some minor changes are required.  
 
I accept the manuscript for publication after revision from the aut hors and correction of the 
minor required changes.  
 
 
Regards  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics  in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in  any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
I declare that I have no competing interests  
 
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to the editors, which will not be published.  
 
I agree to the open peer review policy of the journ al