JerMa88/BMC_Womens_Health_Peer_Reviews huggingface dataset:
Title: Association of Dietary preferences with Primary ovarian insufficiency (POI): a Mendelian
randomization-based analysis
Version: 2 Date: 11 Nov 2024
Reviewer's report:
Keywords should be reconsidered. It should be written more clearly .
The incidence of primary ovarian failure should be written with stronger numerical data. The
prevalence in the world, the differences between regions, and the rate seen in the region where
the study was carried out should be explained with numerical data.
The factors that cause primary ovarian failure should be stated, the importance of these causes
and the researches should be interpreted and included in the introduction.
The limitations, differences between countries and generalizability of the study should be
evaluated.
Title: Association of Dietary preferences with Primary ovarian insufficiency (POI): a Mendelian
randomization-based analysis
Version: 2 Date: 12 Nov 2024
Reviewer's report:
Thank you for your contributions to the Mendelian randomization-based analysis of the
association between dietary preferences and primary ovarian insufficiency (POI). The research
presents intriguing results regarding primary ovarian insufficiency (POI) as a significant cause of
infertility. The authors investigated the causal effects of specific dietary preferences on POI risk
through Mendelian randomization (MR) in order to address an increasingly recognized complex
metabolic disorder. I observed that an MR study was conducted using genetic instrumental
variables (IVs) for 83 dietary preferences derived from the UK Biobank. The Finnish FinnGen
dataset was employed to evaluate POI, a proxy for primary ovarian failure (POF). To account for
pleiotropy and validate the findings, we utilized the Inverse Variance Weighted (IVW) method
as the primary analysis, with the addition of MR-Egger and MR-PRESSO analysis. The findings
indicate that the consumption of high-fat dairy products may be associated with an increased risk
of POI, whereas oily fish and pork consumption may provide protective benefits. Nevertheless,
the authors observed that the variability in the data is reflected in the wide confidence intervals
for specific dietary exposures, such as dairy products. This suggests that larger sample sizes are
necessary to refine these estimates. It is crucial to specify how they mitigate this constraint and
substantiate the study's validity. Thank you.
Title: Association of Dietary preferences with Primary ovarian insufficiency (POI): a Mendelian
randomization-based analysis
Version: 3 Date: 18 Nov 2024
Reviewer's report:
Thank you for your work on the Mendelian randomization-based analysis of the association
between dietary preferences and primary ovarian insufficiency (POI).
I was captivated by the paper and found it to be quite captivating. The Inverse Variance Weighted
method was employed as the primary analysis in an MR study that utilized genetic instrumental
variables to analyze 83 dietary preferences from the UK Biobank. The findings suggest that the
risk of POI may be elevated by high-fat dairy products, while the consumption of oily fish and
pork may provide protective benefits. These results establish a foundation for future clinical and
public health strategies that focus on reproductive health. I discovered that these discoveries
are significant and establish a basis for future clinical and public health strategies that focus
on reproductive health. The authors have addressed the comments that were voiced during the
previous round of review. I extend my fondest wishes to the authors.
Title: Using an electronic patient reported outcome measure (ePAQ-MPH) to assess potential
harm for long-waiting patients in gynaecology
Version: 1 Date: 03 Sep 2024
Reviewer's report:
Well done, an interesting and thought provoking study on how to tackle waiting list times within
Gynaecology services.
The free text finding of patients wanting to be heard was interesting and warrants highlighting
in future qualitative work.
Title: Using an electronic patient reported outcome measure (ePAQ-MPH) to assess potential
harm for long-waiting patients in gynaecology
Version: 1 Date: 17 Sep 2024
Reviewer:  Rohna Kearney
Reviewer's report:
Thank you for the opportunity to review this manuscript. It is to my knowledge the only paper
I have seen trying to reduce harm in the outpatient gynaecology backlog. It is well written and
presented.
The paper presents the result of using an electronic questionnaire as a screening tool to prioritise
outpatient backlogs to reduce harm. It does not give any data on outcome so I don't understand
how it has assessed the success of the tool in reducing or preventing harm. Were any patients
not prioritised found to have come to harm due to the wait. Were those prioritised for earlier
appointments suffering from conditions that would have caused harm if they had not been
reviewed in the 6week timeframe?
Is there a rationale for choosing the score of 80. Has this been validated?
Did the authors consider other factors such as whether the patient had been examined by the
primary referrer to out rule significant pathology for example in irregular vaginal bleeding?
It would be helpful to know the outcomes of the patients who participated ie listed for procedures
and priority, discharged etc to be able to determine whether the tool did what it was used for,
ie prioritise high risk patients at risk of coming to harm if delayed. As it stands the tool has not
fulfilled the aim of the study.
The authors briefly mention the issue of digital poverty. An expanded discussion of how it
may address or lead to health inequalities and the effect of health literacy would improve the
manuscript.
Title: Using an electronic patient reported outcome measure (ePAQ-MPH) to assess potential
harm for long-waiting patients in gynaecology
Version: 1 Date: 19 Sep 2024
Reviewer's report:
This paper focusses on use of an electronic PROM to assess for harm while awaiting
gynaecology appointments. The paper reports on a service evaluation rather than a research
study; however the findings are useful for practice more widely than this one service area.
Abstract: its not clear what the range refers to. The ePAQ-MPH needs to written out in full in
the abstract.
Introduction: Why did they choose 60 weeks as the cut off.  Why not 6 months for example?
Methods:
• It is not clear what is meant by ‘can also be downloaded as an excel file for multiple
completions’ – by the same person or by multiple respondents?
• The name of the UK NHS Trust is in the paper and while it may become obvious that this is the
Trust from where the participants were sampled, it would be more usual to anonymise the site.
• Can they provide a bit more detail about the protocol to contact the potential participants
– contacting 5 times seems quite a lot, perhaps more acceptable in service evaluation than in
research.
Discussion
• Can the findings be contextualised in a more global context for other publicly funded health
systems?
• Is there literature from other related health fields about the use of ePROMs to triage waiting
lists?  Are there any risks of triaging in this way?
Overall, a useful paper that requires some contextualisation beyond the UK to be more useful
to the wide journal readership.
Title: Evaluating the safety and efficacy of wormwood vaginal cream on sexual satisfaction
and quality of sexual life of postmenopausal women: a Randomized, Triple-Blinds, Placebo-
Controlled Clinical Trial
Version: 3 Date: 28 Sep 2024
Reviewer's report:
Thank you for giving me the opportunity to review this interesting study "Evaluating the safety
and efficacy of wormwood vaginal cream on sexual satisfaction and quality of sexual life of
postmenopausal women".
However, I have some comments and recommendations:
Comments:
Title: - Is appropriate for the content of the article.
Abstract:- Represents a suitable summary of the work.
Article content:- The methods and results have been well explained.
Conclusions:- Are justified on the basis of the study.
Recommendations:
References:- Stick to the format of the journal.
General:- Revise language, grammar and syntax.
Title: Evaluating the safety and efficacy of wormwood vaginal cream on sexual satisfaction
and quality of sexual life of postmenopausal women: a Randomized, Triple-Blinds, Placebo-
Controlled Clinical Trial
Version: 3 Date: 28 Sep 2024
Reviewer:  Phuc Nhon Nguyen
Reviewer's report:
Dear authors,
Thank you for your topic concerning mid-life women’s health. I have some major comments:
-Results in abstract should be provided with more data and findings.
-Vaginal bleeding is also a concerned issue in postmenopausal women. Please expand the
introduction. Nguyen PN, Nguyen VT. Evaluating Clinical Features in Intracavitary Uterine
Pathologies among Vietnamese Women Presenting with Peri-and Postmenopausal Bleeding:
A Bicentric Observational Descriptive Analysis. J Midlife Health. 2022;13(3):225-232.
doi:10.4103/jmh.jmh_81_22
-Who monitored the participants used the cream or not?
-Why the study sample size based on a study (Ref 26) with a different drug (ginkgo biloba
tablet and aromatherapy inhaler combination) instead of wormwood vaginal cream?. This
recent study should be more appropriate. Niloofar H, Raheleh B, Roshanak S, Jamshid
J. Evaluation of the safety and efficacy of wormwood vaginal gel in improving sexual
function and sexual satisfaction in women of reproductive age: A randomized, triple-blinds,
placebo-controlled clinical trial. Eur J Obstet Gynecol Reprod Biol. 2023;280:1-6. doi:10.1016/
j.ejogrb.2022.11.002
-Did the study concern vaginal bleeding? This symptom was excluded or included in this study?
-Did the study exclude all the gynecologic pathologies such as vaginitis, cervicitis, fibroids, etc?
-Pelvic organ prolapse could impact on quality of life and sexual function. Please mention it.
-Please define age and spouse age in Tables. Total postmenopausal years should be added.
-Income, residency, and occupation should be added in baseline characteristics.
-Some symptoms relating to postmenopausal period (hot flashes, night sweats, mood swings,
and urogenital atrophy) should be investigated and compared before and after treatment.
-The study flowchart must be improved in quality. Yellow track should be removed.
-The study should be analyzed with the correlation before and after intervention.
-Some graphs should be used to present the results.
-Conclusion should be rewritten. The study only compared wormwood cream with placebo, not
other effective drugs. Meanwhile, the authors concluded that: “Based on this trial, wormwood
vaginal cream can be a reliable choice as a topical supplement to improve sexual satisfaction
and indirectly increase the quality of sexual life of postmenopausal women.”. This statement is
completely inappropriate.
-English editing is strongly required. Grammar errors and syntax should be checked.
-Please correct the upper case for participants (subheading 2.2) and 2.5 statistical analysis.
-Please correct the lowercase for Kidney in 2.2 subheading.
-References should be updated. Almost references are old.
-Full-word should be provided for DASS-21 questionnaire, SPSS.
-The information of SPSS version 26.0 (country, year of product) should be added.
Best regards,
Title: Evaluating the safety and efficacy of wormwood vaginal cream on sexual satisfaction
and quality of sexual life of postmenopausal women: a Randomized, Triple-Blinds, Placebo-
Controlled Clinical Trial
Version: 3 Date: 28 Sep 2024
Reviewer's report:
Thank you very much for the opportunity to review the manuscript.
This manuscript addresses an important issue—the prevalence of sexual dysfunction in
postmenopausal women and investigates the potential role of herbal remedies, specifically
wormwood vaginal cream, as a treatment. The introduction part provides a clear and well-
referenced justification for the study, emphasizing the increasing preference for complementary
and alternative medicine as an alternative to hormone therapy. The trial is well-designed,
utilizing a randomized, triple-blind, placebo-controlled approach. This design effectively
minimizes potential bias and increases the credibility of the findings. The study follows
CONSORT guidelines, as confirmed by the inclusion of a completed CONSORT checklist and
related statements within the manuscript. The statistical methods are appropriate for the study
type. According to the results, sexual satisfaction and quality of sexual life in the intervention
group treated with wormwood cream was significantly improved compared to the placebo group.
Overall, the manuscript has been written well and in the scope of the journal. However, there
are several points that should be addressed in order to improve the quality of the manuscript.
1. Try to provide more specific details regarding the blinding process. The manuscript shows
that it was a triple-blind trial, but clarifying who exactly was blinded would be beneficial.
2. Are there any minor side effects? If yes, please state them.
3. The discussion part would benefit from a more detailed consideration of potential confounding
factors, such as participants' psychological factors, cultural influences, and lifestyle, which may
have influenced the reported outcomes.
I would be happy to review the revised manuscript again.
Title: Evaluating the safety and efficacy of wormwood vaginal cream on sexual satisfaction
and quality of sexual life of postmenopausal women: a Randomized, Triple-Blinds, Placebo-
Controlled Clinical Trial
Version: 4 Date: 10 Nov 2024
Reviewer:  Phuc Nhon Nguyen
Reviewer's report:
Thank you for revision. The paper is more well-improved.
Title: Evaluating the safety and efficacy of wormwood vaginal cream on sexual satisfaction
and quality of sexual life of postmenopausal women: a Randomized, Triple-Blinds, Placebo-
Controlled Clinical Trial
Version: 4 Date: 11 Nov 2024
Reviewer's report:
Thank you very much for the opportunity to review the revised manuscript. It seems to me that
the authors have addressed all concerns raised by the reviewers. I have no further comments
regarding the manuscript.
Title: Evaluating the safety and efficacy of wormwood vaginal cream on sexual satisfaction
and quality of sexual life of postmenopausal women: a Randomized, Triple-Blinds, Placebo-
Controlled Clinical Trial
Version: 4 Date: 11 Nov 2024
Reviewer's report:
Thank you for giving me the opportunity to review this interesting study "Evaluating the safety
and efficacy of wormwood vaginal cream on sexual satisfaction and quality of sexual life of
postmenopausal women".
Almost all reviewer’s comments and recommendations were considered.
Title: Clustering Iranian Women according to their Menopausal Severity Symptoms and
Exploring the Factors Associated with Severe Categories, using Baseline Category Logit Model
Version: 0 Date: 06 Nov 2023
Reviewer's report:
General comments
All parts of the text need native and technical editing. For example, the use of upper and lower
case letters in the text is not properly observed.
References are not set according to style of the Journal
Journal style should be followed in writing the manuscript
Introduction
1. Introduction is too long and isn’t informative about the necessity of cluster analysis.
2. In the introduction, please talk about the cultural differences in Menopausal Severity
Symptoms perceptions.
3.
Methods
1. It’s necessary to more explain about how sampling via multi-stage sampling method?
2. Inclusion criteria for this study were defined as follows: participants who meet the criteria of
being pregnant, or those who have immigrated or hold foreign nationality
These characteristics seem to be the exclusion study criteria.
3. Give a reference for STRAW.
4. It is not explained about how to measure the income of the participants in the study in the
materials and methods section.
5. It is not explained about how to measure the physical activity of the participants in the study
in the materials and methods section
Results
1. More explanations are needed to explain the demographic variables.
2. About 87% were married or partnered, 59% had 1 or 2 children, 55% reported no Resent
disease and 86% reported no Psychological problem.
Do you mean "recent"?
3. What do you mean by the word "free" in the job classes of husbands?
4. In table 1,  * What does the refer to?
5. The data shows that the most commonly reported symptoms of menopause were pain in
muscles and joints (45.2%), followed by anxiety (34.1%) and vasomotor symptoms (0.41%).
Is it correct?
Discussion
Discussion section, instead of showing results that have been presented in the results section,
I recommend discuss more in-depth about possible explanations of these findings and study
implications, such as recommendations.
Title: Clustering Iranian Women according to their Menopausal Severity Symptoms and
Exploring the Factors Associated with Severe Categories, using Baseline Category Logit Model
Version: 0 Date: 15 Nov 2023
Reviewer's report:
The topic is very relevant. The method chosen to do this is consistent. In particular, the method
used corresponds to the quality requirements for such work.
The presentation of different steps indicates compliance with the statistical rules. However, some
minor comments as follows:
Introduction:
Menopause age in Iran should be mentioned. What is the prevalence of symptoms in Iran?
- The reference is not this part? "For instance, in the study of Cray, Woods, and Mitchell,
the researchers" explored mood component, vasomotor component, and pain component in
menopausal symptoms"
- Also the reference of this section
"in the study of Mishra & Kuh (2018), Using Clusters of midlife women, four clusters
were extracted through hierarchical cluster analyses. No study in the literature has examined
clustering of menopause symptoms in midwife women in Mashhad city, Iran. Thus, this study
is one of the first cluster analyzes to examine the associations of menopause severity symptoms
during menopausal transition by conducting a cluster analysis by women".
Method:
- The age of menopause in Iran is 51 years. Mention the reference sources in this section and
why did you include people 9 years older and 9 years younger in the study?
- Inclusion criteria: It is not clear whether you are pregnant? Have they immigrated or have
foreign citizenship? Is this your entry criteria? Or exit? If it is an exit, why is the history of
illness or hormone therapy not mentioned?
- On what basis and formula were 664 people selected? What formula?
- The research process is not mentioned. The sampling method should be clearly mentioned.
Discuss:
- The number of people in the clusters does not need to be mentioned and the percentage is
sufficient.
- The limitation should be given at the end of the discussion
- Practical suggestions should also be mentioned in the results.
* There are clearly many grammatical errors in the manuscript.
Title: Clustering Iranian Women according to their Menopausal Severity Symptoms and
Exploring the Factors Associated with Severe Categories, using Baseline Category Logit Model
Version: 3 Date: 05 Apr 2024
Reviewer's report:
Dear authors,
1.Please write the keywords accordingly.
2.The entire text needs to be edited.
3.Please explain more about this sentence'Clustering analysis can help in identifying the
association between risk factors and the severity of menopause symptoms and identification of
at-risk groups [27]".
4.Background diseases such as: diabetes, blood pressure, etc. affect the symptoms of menopause.
Why is it neglected?
5.Not explained about the sampling method?
6.It is not explained about the sampling location.
7.After ANOVA, post hoc tests were not used.
8.The number of pages is not specified.
9.It seems that the authors submitted this article in a hurry. Some highlights can be seen in the
manuscript.
Title: Clustering Iranian Women according to their Menopausal Severity Symptoms and
Exploring the Factors Associated with Severe Categories, using Baseline Category Logit Model
Version: 4 Date: 06 Jul 2024
Reviewer's report:
Thank you as you responded the previous comments of reviewers. Although in general the
responses were comprehensive, but some issues remained that should be addressed by authors
as follows:
Abstract
1. why authors recruited women aged 42 to 60. According to the definition of middle age, it
is from 45 to 60.
2. I would like to see a better interpretation for the results of the study e.g. those with advanced
aged experienced more severe menopausal symptoms.
3. Why conclusion should be according to the findings of the study.
Introduction
1. Why the main symptoms of menopause are different among Western women and Islamic
women?
2. What is the meaning of “ nova” in the 6th paragraph?
Methods
1. Please write about demographic questionnaire.
2. Please re-write the method section according to STORBE guideline.
3. Authors should report more details about MSSI-38 questionnaire such as minimum and
maximum scores.
Results
1. Please change the result to “Results”.
2. Although authors claimed that they categorized women according to STRAW classification,
I could not see any results of this classification in the results section.
3. Table 1: what were the underlying disease and psychological problems? You can mention
them under the table.
4. Please revise the BMI in the table. I think authors put the symbols mistakenly.
5. Figure 1 is not diagram and is a figure, please revise.
6. Some of terms that used in table 2 is not correct, for instance “urine loss” is not correct and
should be replaced by “urine leakage”. Felling a loss or lack of memory” is not correct. “Feeling
dizzy or faintin” does not make sense.
7. Please indicate the statistical tests for each table.
8. What is the meaning of cluster 1a and 2b in table 4?
9. Instead of ANOVA, authors could use multiple linear regression.
DISCUSSION
1. Paragraph 4 is more appropriate for introduction and not discussion.
2. Paragraph 8 is not related to the field of this study, and I recommend deleting it. Anxiety and
depression have many other reasons than the Iran-Iraq war.
3. The conclusion is not according to the finding of the study.
4. One of the limitations of this study is they did not use physical activity questionnaire to
measure physical activity of participants.
References
please use the abbreviation name of journals in all references.
Finally, although authors claimed that they edited the manuscript, the manuscript has still some
grammatical and typo errors, and should be edited by a native English linguistic.
Title: Clustering Iranian Women according to their Menopausal Severity Symptoms and
Exploring the Factors Associated with Severe Categories, using Baseline Category Logit Model
Version: 7 Date: 13 Oct 2024
Reviewer's report:
Dear Authors,
Thank you for submitting your manuscript titled “Clustering Iranian Women according to their
Menopausal Severity Symptoms and Exploring the Factors Associated with Severe Categories,
using Baseline Category Logit Model.”
After a thorough review and careful consideration, I would like to commend your valuable
research contribution. The methodology employed, particularly the use of the baseline category
logit model, is sound and provides meaningful insights into the factors influencing menopausal
severity among Iranian women. Your clustering approach is innovative and addresses an
important public health issue, making this work highly relevant for the field.
Therefore, I am pleased to inform you that the manuscript is accepted for publication in its
current form. We look forward to seeing your continued contributions to this critical area of
research.
Congratulations on your excellent work!
Sincerely,