Reviewer’ s report
Title: Abstract The effect of oxytocin vaginal gel on vaginal atrophy in postmenopausal
women: a randomized controlled trial
Version: 0Date: 01 Oct 2019
Reviewer: Angelo Cagnacci
Reviewer's report:
Please include all comments for the authors in this box rather than uploading your report as an
attachment. Please only upload as attachments annotated versions of manuscripts, graphs,supporting materials or other aspects of your report which cannot be included in a textformat.Please overwrite this text when adding your comments to the authors.The study isinteresting and well done, but statistical analysis is not appropriate. English grammar and syntaxshould be revised.Specific points:Treatment for 8 weeks is rather short considering that VV A is achronic conditions lasting for all the postmenopausal period. Longer studies should be moreappropriate.There is no indication about the type of oxytocin used (manufacturer etc) and howthey checked it was active oxytocinStatistical analysis : What is GEE? Changes in the two groupsshould be compared By Two factors ANOV A for repeatead measures. T test is inappropriate fordata of Table 3In the discussion there is very little explanation on the mechanism of action. Whydid they chose oxytocin and not any other thing?
Are the methods appropriate and well described?
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Yes
Does the work include the necessary controls?
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YesAre the conclusions drawn adequately supported by the data shown?
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YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being publishedDeclaration of competing interests
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