Reviewer’s report
Title: 
Nodular malignant melanoma in vulvar skin without pigmentation: a case
report
Version: 
1 
Date: 
10 Mar 2021
Reviewer's report:
This is a case report of a patient with vulvar malignant melanoma initially
presenting as a vulvar polyp without pigmentation. It brings nothing particularly
new to the existing body of literature as the presentation of vulvar malignant
melanoma may vary significantly (as correctly acknowledged by the authors) and
amelanocitic polyps are a frequent clinical manifestation. In addition vulvar
melanoma is the second most common malignancy on the vulva (after squamous
cell cancer). In the discussion the authors should focus on the differences
between cutaneous and genital melanomas. What are the differences in
prognosis, mutational profile, are there any differences in histopathologic
characteristics? Finally, the lack of follow-up data significantly decreases the
impact of this manuscript.
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Is the study design appropriate to answer the research question (including the use
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presented?
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