JerMa88/BMC_Womens_Health_Peer_Reviews huggingface dataset:
Title: Interaction of reproductive tract infections with estrogen exposure on breast cancer risk
and prognosis
Version: 1 Date: 04 Jan 2023
Reviewer:  Giuseppe Gullo
Reviewer's report:
Dear authors,
I read with great interest the manuscript, which falls within the aim of this Journal. In my honest
opinion, the topic is interesting enough to attract the readers’ attention. Nevertheless, authors
should clarify some points and improve the discussion, as suggested below. Authors should
consider the following recommendations:
In my opinion you have to improve the paper refering in the text how  IN CASE of associations
of pre-diagnosis reproductive tract infections with risk and prognosis of breast cancer these pts
need to preserve their fertility, by freezing thier gamtes by vitrification tecnique ,with an inositol
supplenetation before ovarian stimulation because a poor oocytes quality can be improve with
inositols supplementation due multiple inositols role from ovulation induction to menopausal
disorders treatment especially in pts that are doing an IVF TREATMENT IN INFERTILE
PATHWAY and especially in pts that have tried all the known tecnique in literature as  Injection
of embryo culture supernatant to the endometrial cavity,USUALLYin 50% cases BY male
factor.
Its also important to refer how is important to have in this couple a gender tailored approach and
pay attention to the psychological implication.
I suggest you to read and cite these articles:
Injection of embryo culture supernatant to the endometrial cavity does not affect outcomes in
IVF/ICSI or oocyte donation cycles: A randomized clinical trial
Cryptic sperm defects may be the cause for total fertilization failure in oocyte donor cycles
The gender gap in the diagnostic-therapeutic journey of the infertile couple.
How does closed system vitrification of human oocytes affect the clinical outcome? A
prospective, observational, cohort, noninferiority trial in an oocyte donation program
Myo-inositol: from induction of ovulation to menopausal disorder management
Myo-inositol and melatonin in the menopausal transition
D-chiro-inositol induces ovulation in non-polycystic ovary syndrome (Pcos), non-insulin-
resistant young women, likely by modulating aromatase expression: A report of 2 cases
Fertility preservation in female cancer sufferers: (only) a moral obligation?
Oncofertility and Reproductive Counseling in Patients with Breast Cancer: A Retrospective
Study.
An association of boswellia, betaine and myo-inositol (Eumastós®) in the treatment of
mammographic breast density: a randomized,double-bind study.
Myoinositol plus #-lactalbumin supplementation, insulin resistance and birth outcomes in
women with gestational diabetes mellitus: a randomized, controlled study
Psychological variables in medically assisted reproduction: a systematic review
Title: Interaction of reproductive tract infections with estrogen exposure on breast cancer risk
and prognosis
Version: 1 Date: 16 Jan 2023
Reviewer:  Mario Palumbo
Reviewer's report:
I was pleased to review this paper
The methodology used by the Authors is appropriate for the purpose of the article description.
The English language is fluid and well understood. Nevertheless, minor revision is needed;
For the abstract I found clear the schematization of the content;
Regarding the introduction you can add this paper to deepen the topic read this paper  doi:
10.1002/ijc.33319;
Can you clarify if the use of vaginal probiotics can be useful in protecting the microbiome and
therefore avoiding future inflammatory processes?
Should the use of routine vaginal swabs against suspected infection be increased?
In women with a long life and increased exposure to oncogenic factors do not you think it is
extraordinarily difficult not to fall into bias information collection determined?
- The statistical structure seems to me well done;
- Good subdivision into subparagraphs;
- Good  mention of the limitations study;
- Increase the number of references;
The data obtained are good with respect to the structuring of the work.
Title: Interaction of reproductive tract infections with estrogen exposure on breast cancer risk
and prognosis
Version: 4 Date: 14 Mar 2023
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
No - there are minor issues
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The authors reply to the comments by mostly commenting on the
limitations of the study but without adding any significant changes in it. More details about these
responses should also appear in the text. Overall, it is improves but some minor issues should
still be addressed.
REQUESTED REVISIONS:
The authors do not modify the text significantly according to comments, they don't even add the
missing information as limitations in the article. They should:
1/ Clearly explain what they mean by infections since this is the principal message and this
is not defined: all bacteria, viruses, with specifically mentioning HPV, all GYN organs? This
missing info should be clearly stated, not just ""all pathogens were considered and no details
about were available"".
2/ Similarly, they don't even respond to the question HOW the infections were ""diagnosed"",
the role of generalist or gynecologist is not clear.
3/ This leads to an important question: the authors do not comment, do not include in the data, the
fact of control of these women. Did they all follow regularly their generalist/gyneco for control?
Patients with known HPV infections for example, would most regularly see their gynecologist,
which will bias their breast control also, and thus the results of the study, in comparison to
women that did not regularly visit their gynecologist, and thus develop breast invasive lesions
left undiagnosed due to not visiting a gynecologist...This is also reflected by the educational
status probably which is indeed different.
4/ the use of contraceptives should be included in the analysis of breast cancer risk / prognosis
not only infections.
5/ The authors should better search the literature for breast cancer and HPV relationship since
this is included as infection in their analysis. And add this information."
Title: Interaction of reproductive tract infections with estrogen exposure on breast cancer risk
and prognosis
Version: 5 Date: 07 Apr 2023
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: Indeed, this time the authors respond and include in their text most
of the previously unresolved issues.
They should include in the limitations (bias) the fact the patients with infection such as HPV
infection probably visited their gynecologists more often impacting in the detection of the breast
lesions. The comparison that they make for stage with other studies has no value.
REQUESTED REVISIONS:
The authors should just add the limitation regarding the (probably) most frequent consultation
for patients with infection in their text (not just in the responses)."
Title: Interaction of reproductive tract infections with estrogen exposure on breast cancer risk
and prognosis
Version: 6 Date: 15 Apr 2023
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The authors had considerably improved their work and included all
changes in the text. Most important, the limitations are now well explained."
Title: Prevalence of depression, syndemic factors and their impact on viral suppression among
female sex workers living with HIV in eThekwini, South Africa
Version: 4 Date: 08 Dec 2022
Reviewer's report:
The present manuscript presents baseline, cross-sectional data from female sex workers (FSWs)
living with HIV enrolled in a large intervention study in eThekwini, South Africa. Guided by
syndemics theory and the Substance Abuse, Violence, and AIDS (SAVA) syndemic factors,
the authors examined associations between various factors (including SAVA syndemic factors),
depression, and viral suppression. Strengths of this study include its large sample size (especially
considering this can be a hard-to-reach population) and examination of multiple factors that may
be related to depression and viral suppression. I believe this is an important paper that should
ultimately be published. However, before it is formally accepted, I recommend that the authors
address the following minor points:
Minor Comments:
METHODS
- In the “Study Setting and Population” paragraph, the authors should more clearly state that
the present study only uses data from the baseline assessment. Including information about
randomization is confusing, and had me questioning whether everyone’s baseline data was used
or only those who were suppressed or non-suppressed at baseline. As randomization is not
relevant to this manuscript, I suggest removing information around randomization, and instead,
stating that the present manuscript presents baseline data from a larger intervention study.
- Please clarify what is meant by peer case managers. Are these case managers with lived sex
work experience? Or someone else?
- What were the genders (or any other potentially relevant characteristics) of the interviewers?
Could this have affected participants’ answers?
- Categories are listed for all factors except HIV/AIDS (line 133). To keep this consistent, I
recommend listing these categories.
- Why was sexual violence measured as a history of lifetime rape versus non-rape sexual assault?
Were participants given a definition of rape, or just asked about rape generally?
- Please clarify in the methods section whether you are looking at stigma towards HIV, stigma
towards sex work, or stigma towards something else. Additionally, did the researchers create
this stigma scale or has it previously been used/ validated? Please explain the rationale behind
this decision.
Results
- Were types of substances used in the past month reported? If so, which substances were
reported? Are you able to look at the data to see if any particular substances were or were not
associated with depression or viral suppression?
Discussion / Conclusion
- The researchers mention that non-mental health professionals, such as the peer case managers,
may be able to refer at-risk women for mental health care. What mental health care referrals
currently exist? Are there treatments in place, or is this another thing that needs to be developed?
General
- Please double check the grammar throughout the manuscript.
Title: Prevalence of depression, syndemic factors and their impact on viral suppression among
female sex workers living with HIV in eThekwini, South Africa
Version: 6 Date: 04 Apr 2023
Reviewer's report:
Although it was a bit unclear in the response to the reviews, the authors have addressed the points
raised. In the future, it would be helpful to present a point-by-point response to each comment
demonstrating how it has been addressed.
Title: “I wanted information”: Navigating Breast Cancer and Its Treatment in Lima, Peru
Version: 2 Date: 14 Feb 2023
Reviewer's report:
Thank you for the opportunity to review this interesting study. In this study, authors present
a qualitative study of the experience of a diagnosis of breast cancer in women in Peru.  The
manuscript is very well written, clear, and concise. The methods are well detailed.  I would
also like to applaud the investigators on evaluating perspectives of this population that is
understudied. This population does represent a vulnerable group and thus interventions for
this group of patients are very important. It is a small study and they address the limitations
appropriately.
Title: Association between tissue stress reaction and ACE2/TMPRSS2 expression in endometria
of reproductive aged women before and during Covid-19 pandemic
Version: 1 Date: 05 Apr 2023
Reviewer:  Henry Dilonga Meriki
Reviewer's report:
This study aimed to investigate the relationship between tissue stress reaction and the expression
of SARS-CoV-2 cell entry proteins in the endometria of women before and during the Covid-19
pandemic. However, there are some suggestions to improve the clarity of the manuscript.
Minor suggestions:
The study's title should indicate the disease state of the samples used.
Abstract:
• Line 35: Avoid using subjective language such as "alarming concern" and use more objective
terms.
• Line 39-40: Clarify the term "endometrial tissue stress reaction."
• Line 46-47: Revise the phrase "with these two groups of endometrial samples" for clarity.
Background:
• The background section seems lengthy and should be contrasted.
• Line 72: Remove "own" from the sentence "Japan confirmed its own first case."
Methods:
• Line 168: Instead of "in-pandemic," use "during the pandemic," and correct it throughout the
manuscript.
• Line 169: Replace "gravity" with "gravidity."
Results:
• Include a correlation line in Figure 3 to indicate the direction.
Discussion:
• Line 333: Clarify whether the study is a cohort or a case-control study since the statement
"retrospective case-controlled cohort study" is unclear.
•  Line 340-342: Although the authors made inferences about menstrual cycle stages and
age, the study population described are women in their late menstrual period, generally prone
to menstrual irregularities. Thus, the findings may not be over generalized to women of
childbearing age (15-35 years).
• Line 484: Define the meaning of ART upon first use.
Conclusion:
• The conclusion and recommendations should be based only on the findings of this study.
Title: Quality of life in patients with cervical cancerbetween the Han nationality and ethnic
minorities in the Yunnan Province of China
Version: 2 Date: 01 Dec 2022
Reviewer's report:
Revision of a Manuscript
Journal: BMC Women's Health
Title: The quality of life in patients with cervical cancer between Han and Ethnic minority in
Yunnan Province of China
Authors: Min Zhao et al.
To me, this paper is a good one and the text was very simple, fluent and clear and I enjoyed
reading this paper.
The correct methodology was used to achieve the research aim. The Functional Assessment
of Cancer Therapy-cervix cancer (FACT-Cx) (Chinese vision 4.0) was applied to assess the
QOL in this study. But I have question about sample size, why did you choose this quantity of
respondents?
I think statistical analysis corresponding to this type of study.
The availability of data adheres to the expected standards of our research community.
Authors in the discussion used known data from previous literature.
It is not necessary to revised to address manuscript for any potential limitations.
My decision: this manuscript should be accepted
Title: Quality of life in patients with cervical cancerbetween the Han nationality and ethnic
minorities in the Yunnan Province of China
Version: 2 Date: 05 Dec 2022
Reviewer's report:
Thank you for the opportunity to review this interesting and important manuscript entitled “The
quality of life in patients with cervical cancer between Han and Ethnic minority in Yunnan
Province of China”. Ethnic minorities are often overlooked and thus need more attention.
1. Introduction section, line 57 : “there will be 604,000 new cases….in 2020.” Now we are
approaching 2023. Please reword the sentence with the correct tenses.
2. Introduction section, line 64 : “Cervical cancer ranked the second female malignant tumor
in China…”, please make this a start of a new paragraph (2nd paragraph) about cervical cancer
situation in China.
3. Introduction section, line 73 to 76: “The CIR and CMR of cervical cancer in Yunnan
province….”, please move up to the 2nd paragraph about cervical cancer situation in China.
4. Introduction section, line 76: “However, cervical cancer is considered… “, please start a new
paragraph (3rd paragraph) starting from this sentence.
5. Line 73 to 76: The CIR and CMR of cervical cancer in Yunnan province were 17.39/100,000
and 5.14/100,000, and both rates were higher than those of China and some western countries[6].
Up to 2016, the CIR and CMR of cervical cancer in Yunnan province were 16.01/100,000 and
5.39/100,000[7]. ... Why there are two sentences about the CIR and CMR statistics? The first
sentence is unclear, from what year was it? Please consider including only the recent statistics.
6. Line 108 : “In recent years, the HRQOL of patients with cervical cancer and precancerous
lesions has been attracted attention at home and abroad [18-20]”.  “at home”? Did you mean in
China? Please make it clear.
7. Please add a brief description of HRQOL data of the patients with cervical cancer in China,
especially in Yunnan Province. Was the HRQOL good, poor, etc?
8. Please add why it is important to assess HRQOL specifically for cervical cancer patients
(which could be related to their sexuality and gender identity as women).
9. Please elaborate how the patient recruitment was conducted? How many patients were
approached, how many declined, what were the reasons? participation rate?
10. In table 2 and 3, please indicate the statistically significant results with * and mention the
level of significance
11. Line 257: no need to mention XIA Xuan
12. In discussion line 267, please also refer to the finding of your study that poor HRQOL was
found in patients with advanced stage (page 240) and that one of the independent predictors of
HRQOL was clinical stage (page 250).
13. In discussion, paragraph 5 about the ethnic minority’s explanation, please discuss more
how false belief about health could influence HRQOL? Which aspect of HRQOL (emotional?
Social?) could be affected by false belief?
14. An extensive English language editing by a professional native language editor is needed
for this manuscript.
Title: Quality of life in patients with cervical cancerbetween the Han nationality and ethnic
minorities in the Yunnan Province of China
Version: 4 Date: 04 Jan 2023
Reviewer's report:
Dear Authors,
Thank you for the revised manuscript. I am really impressed with the improvement that has
been made throughout the manuscript. The authors have clearly shown a substantial effort to
respond to the reviewer's comments and ameliorate the manuscript. I am happy to recommend
the acceptance of this manuscript.
Title: Quality of life in patients with cervical cancerbetween the Han nationality and ethnic
minorities in the Yunnan Province of China
Version: 4 Date: 21 Jan 2023
Reviewer's report:
To me, this paper is a good one and the text was very simple, fluent and clear and I enjoyed
reading this paper.
The correct methodology was used to achieve the research aim. The Functional Assessment
of Cancer Therapy-cervix cancer (FACT-Cx) (Chinese vision 4.0) was applied to assess the
QOL in this study. But I have question about sample size, why did you choose this quantity of
respondents?
I think statistical analysis corresponding to this type of study.
The availability of data adheres to the expected standards of our research community.
Authors in the discussion used known data from previous literature.
It is not necessary to revised to address manuscript for any potential limitations.
My decision: this manuscript should be accepted