Reviewer ’s report  
 
Title: HPV Genotype Prevalence and Distribution during 2009 -2018 in Xinjiang, China: 
Baseline  Surveys Prior to Mass HPV Vaccination  
 
Version: 1 Date: 12 A pr 2019  
 
Reviewer: Zulqarnain Baloch  
 
Reviewer's report:  
 
I review this manuscript submitted by wang et al., I am not satisfy from study, I think they did 
not have planed well, they just have collected the hospital based data (hospital based samples), 
and reported  author mention that they have adopted good qualit y control protocol  
 
Quality control of HPV genotyping and data input procedures were implemented throughout the 
study but he did not mention how he run the quality control protocol  
 
how they transfer the sample to the lab, after how much time they started lab work, their lab have 
HPV detection and genotyping apparatus in 2009?  
 
how they perform DNA extraction process, how they manage quality of DNA what type of 
positive and negative control hey run beside their samples  
 
they mention that they use Genotypin g Detection Kit (Microarray) (Crystal Core®, 340010, 
CapitalBio Corporation, China), please explain your quality control protocol during genotyping 
process   
 
as they mention, this kit can only genotype 22 HPV genotypes, how about sample which positive 
for HPV but failed to genotype, how you deal with those samples.  
 
why they did not add potential risk factors survey for high HPV prevalence among different 
ethnic groups during different time period  
 
please discuss your ethnic results with data reported i n other ethnic groups from other regions of 
China Hani, Tibtan in Yunnan province.  
 
 
 
 
 
 
 
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
No 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
No 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
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3. Do you hold or are you currently applying for any patents relating to the content of the  
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4. Have you recei ved reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
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below.  If your reply is yes to any, please give details below.  
 
no competing interest  
 
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