Reviewer’s report
Title: 
Unilateral ovarian recurrence 5 years after hysterectomy for microinvasive
squamous cervical cancer stage IA1: a rare case report
Version: 
1 
Date: 
20 Feb 2023
Reviewer's report:
This is a case report of an ovarian recurrence five years after primary treatment
of cervical SCC stage Ia1. I have the following comments:
1. The authors should expand the introduction section with the rates of cervical
SCC recurrences in different stages. How common is ovarian recurrence in
adenocarcinoma?
2. Which immunohistochemical markers are commonly used for the
differentiation of primary ovarian tumours and ovarian metastases? This
information should be added to the introduction section.
3. Discussion section, line 59: the authors state that the standard treatment of
FIGO IA1 CC is simple hysterectomy which is not true. What is the treatment of
choice for patients wishing to preserve their fertility?
4. The discussion should be more balanced. The authors should include the
recommendations of various international guidelines for the treatment of local,
regional and distant recurrences of cervical cancer.
5. Is it prudent to routinely evaluate SCC-Ag in patients who undergo follow-up
after the primary treatment?
6. I suggest English editing of the text.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
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No
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No
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No
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes
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No