Reviewer’s report
Title: Association between type 1 diabetes and female sexual dysfunction
Version: 1 Date: 22 Dec 2019
Reviewer: Lúcia Alves Silva Lara
Reviewer's report:
Please include all comments  for the authors in this  box rather than uploading your report as an
attachment. Please only upload as attachments annotated versions of manuscripts, graphs, supporting
materials or other aspects of your report which cannot be included in a text format.
Please overwrite this text when adding your comments to the authors.
Review response
Manuscript titled "The impact of type 1 diabetes on female sexual dysfunction" is a case-control study
involving 33 women with type 1 DM and 39 healthy women as controls aiming to assess: 1) the
prevalence of Female Sexual Dysfunction (FSD) in women affected by type 1 Diabetes Mellitus (DM)
and the control group; 2) the correlation between FSD and Body Mass Index (BMI); 3) the correlation
between  duration  of  DM,  HbA1C  and  FSD;  4)  the  impact  of  the  different  methods  of  insulin
administration; and 5) the correlation between FSD and diabetes complications.
Introduction
Authors should assess references in this field as shown below (case-control study).
Dimitropoulos K1, Bargiota A2, Mouzas O3, Melekos M1, Koukoulis G2, Tzortzis V1. Dissatisfaction
with male sexual performance and female sexual dysfunction in women with type 1 diabetes. Int J
Impot Res. 2015 Jan-Feb;27(1):25-8. doi: 10.1038/ijir.2014.21. Epub 2014 Jul 10.
According to a recent study (7),…reference 7 is from 2003
"…negative impact on female sexuality". It is fundamental to discriminate the subject that authors are
talking about (sexuality or sexual dysfunction?). 
Methods  should  be  detailed  according  to  study  design,  sample  size  calculation,  the  period  that
participants were invited, who invited them, where they respond questionnaires.
Results: MBI (as well as waist to hip circumference) is significant different between groups and this is
an important bias as obesity is an independent factor for female sexual dysfunction, and the lack of
sample size calculation may add negative value in this aspect. 
Table 3 should show both groups and p value
Show a legend with acronyms signification for all tables
.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
No
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Unable to assess
Are you able to assess any statistics in the manuscript or would you recommend an additional
statistical review?
If  an  additional  statistical  review  is  recommended,  please  specify  what  aspects  require  further
assessment in your comments to the editors.
Not relevant to this manuscript
Quality of written English
Please indicate the quality of language in the manuscript:
Not suitable for publication unless extensively edited
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of this
manuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?
6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below. If
your reply is yes to any, please give details below.
I declare no for all 6 questions
I agree to the open peer review policy of the journal. I understand that my name will be included on my
report to the authors and, if the manuscript is accepted for publication, my named report including any 
attachments I upload will be posted on the website along with the authors' responses. I agree for my 
report to be made available under an Open Access Creative Commons CC-BY license 
(http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments which I do not wish to 
be included in my named report can be included as confidential comments to the editors, which will not
be published.
I agree to the open peer review policy of the journal