Reviewer’ s report
Title: Abstract The effect of oxytocin vaginal gel on vaginal atrophy in postmenopausal
women: a randomized controlled trial
Version: 0Date: 02 Oct 2019
Reviewer: Haitham Atef Torky
Reviewer's report:
Please include all comments for the authors in this box rather than uploading your report as an
attachment. Please only upload as attachments annotated versions of manuscripts, graphs,supporting materials or other aspects of your report which cannot be included in a textformat.Please overwrite this text when adding your comments to the authors.Methods: Please addto the text that patients were consented for the procedures. Please also mention did you do FSHlevels for all the patients? and it's timing. You used a score sheet for assessing symptoms ofvaginal atrophy but you didn't mention starting from which score you considered the patienthaving symptoms of vaginal atrophy. Please provide details.Results: Please add the mean durationof menopause for both groups. Was there a significant difference in this duration between bothgroups?You mentioned the difference in the maturation index before and after treatment, youshould also add a third column for the follow-up after 2 weeks as you stated in the methods (Thiswas only done for vaginal symptoms).You mentioned that there were no reported side-effects,however, in the consort chart 1 patient from each group withdrew because of vaginalburning.Discussion: Please add points of future research in this topic.Minor grammar mistakesneed to be corrected.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
NoDoes the work include the necessary controls?
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YesAre the conclusions drawn adequately supported by the data shown?
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YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require further
assessment in your comments to the editors.
I recommend additional statistical review
Quality of written English
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Needs some language corrections before being publishedDeclaration of competing interests
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