JerMa88/BMC_Womens_Health_Peer_Reviews huggingface dataset:
Title: Treatment of secondary uterine malignancy following radiotherapy for cervical cancer:
a study based on the SEER database
Version: 2 Date: 01 Aug 2024
Reviewer's report:
I read the Manuscript titled “Treatment for second uterine malignancy following radiotherapy for
cervical cancer: a study based on the SEER database” which falls within the aim of the Journal.
Although the manuscript can be considered already of good quality, I would suggest following
recommendations:
- I suggest a round of language revision, in order to correct few typos and improve readability.
- The management of advanced/metastatic cervical cancer is still a challenge. Authors should
read and add references about recent evidence about adequate treatment and pharmacotherapy
in this cohort of patients, considering novel drugs, future perspectives and tailored-treatment
possibilities. I would be glad if the authors discuss this important point, referring to PMID:
38159033 and 38654319.
Because of these reasons, the article should be revised and completed. Considering all these
points, I think it could be of interest to the readers and, in my opinion, it deserves the priority
to be published after minor revisions.
Title: Treatment of secondary uterine malignancy following radiotherapy for cervical cancer:
a study based on the SEER database
Version: 2 Date: 03 Aug 2024
Reviewer's report:
This report addresses the possible optimal treatments for patients with radiation-induced second
malignancies based on the SEER database. The study enrolled 115 patients who developed
SMNs after cervical cancer RT and 27 patients who developed SMNs after receiving non-
radiotherapy treatment for cervical cancer.
General rules
1- please read and follow the instructions for authors reading the formatting of the
submitted manuscript. https://bmcwomenshealth.biomedcentral.com/submission-guidelines/
preparing-your-manuscript
2- Please use ONLY one dictionary for the text of the manuscript.
3- Please do not cite manuscripts published in predatory journals (read the ICMJE guidelines)
4- Please provide a list of abbreviations.
Comments
1- Please do not use abbreviations in the abstract.
2- The title should reflect the work. The study included patients who developed SMNs after
receiving non-radiotherapy treatment for cervical cancer.
3- Authors must cite the R package used and  the base R.
4- P values need to be reported as equality,  e.g. P = 0.004
5- Table 3, what is the value of the P value here.
6- The main HR results must be provided in the abstract. The HR in the main text need
clarification. Kindly request a knowledgeable statistician help before submitting the revision.
7- The conclusion should not include P values and P values all over the manuscript must be
provided as equality (see comment 4 above)
8- The conclusion is vague and needs clarification.
Title: Treatment of secondary uterine malignancy following radiotherapy for cervical cancer:
a study based on the SEER database
Version: 2 Date: 03 Aug 2024
Reviewer's report:
This study demonstrated the best treatment for second uterine malignancy following
radiotherapy for cervical cancer based on the SEER database. Univariate and multivariate
analyses were performed using the COX regression model and Kaplan-Meier survival curves
in different groups were analyzed. This study suggested that surgery improved prognosis
of patients who developed SMN after radiation therapy. In subgroup analysis, the survival
outcome of patients treated with surgery and chemotherapy was superior to other treatment
methods, which provided a treatment modality for cervical cancer patients with radiotherapy-
induced second uterine malignancy tumor. Therefore, I suggest it be accepted after the author
complements the content, articulates the obscure content, and corrects the format.
1. The main object of this study is secondary uterine malignancies, so using SMN in the abstract
is not accurate.
2. The first time an abbreviation is used in an abstract, it should indicate its full explanation,
such as SMN, OPS, CT, etc.
3. The logic of the introduction is not clear. Reference 6 demonstrated that cervical cancer
patients treated with radiotherapy were at increased risk for all second cancers and cancers at
heavily irradiated sites (colon, rectum/anus, urinary bladder, ovary, and genital sites). But in
materials and methods section, SMN refers to uterine malignancies that occur >12 months after
the diagnosis of PCC. A more precise description of SMN is needed in the introduction section.
4. Several patients with SMN were mentioned in the introduction with aggressive histological
types and poor survival outcomes. This can be further described in the discussion section.
5. "CT+RT" in Table 5 is inconsistent with "RT and CT" in the result. "Lantecy" in Table 5,
Table 6, Table 7, and Table 8 should be " Latency". Table 6 format is inconsistent. Figure 3
"chemotheray" should be "chemotherapy ". The punctuation in Figure 3 is inconsistent.
6. The file format of the figures is wrong. It's obscure and hard to see.
7. In the discussion section, common surgical methods and chemotherapy regimens could be
discussed to provide suggestions for the follow-up treatment of SMN.
8. Some of the references are not in the right format.
Title: Treatment of secondary uterine malignancy following radiotherapy for cervical cancer:
a study based on the SEER database
Version: 2 Date: 05 Aug 2024
Reviewer's report:
Suggestions/comments to improve your manuscript:
Introduction:
The introduction lacks a clear explanation of the study's novelty and significance (Lines
1-27). The rationale behind focusing on second uterine malignancies specifically following
radiotherapy for cervical cancer is not well-established.
Methods:
The inclusion and exclusion criteria are poorly defined (Lines 92-117). There is no mention of
controlling for confounding factors such as comorbidities or socioeconomic status, which could
significantly impact survival outcomes.
The description of the statistical methods is insufficient (Lines 157-166). It is unclear whether
appropriate adjustments were made for multiple comparisons in the univariate and multivariate
analyses.
Results:
The results section is overly descriptive and lacks depth (Lines 171-222). There is minimal
interpretation of the statistical findings, and the implications of the identified prognostic factors
are not well-explained.
The presentation of data in Tables 1 and 2 is confusing and redundant. The tables could be
consolidated to improve clarity.
Discussion:
The discussion fails to critically analyze the study's limitations, such as the retrospective design
and potential selection bias (Lines 332-352). There is also no mention of the potential impact
of missing data on the study's findings.
The authors do not adequately compare their results with existing literature (Lines 364-395).
This makes it difficult to contextualize the findings within the broader field of research.
Conclusion:
The conclusion is not well-supported by the data presented (Lines 396-409). The authors make
broad statements about the efficacy of surgery and chemotherapy without sufficient evidence
from their analysis.
There is a lack of clear recommendations for clinical practice or future research, which
diminishes the potential impact of the study.
Title: Treatment of secondary uterine malignancy following radiotherapy for cervical cancer:
a study based on the SEER database
Version: 2 Date: 05 Aug 2024
Reviewer:  Nicolae Gic#
Reviewer's report:
Dear author’s
I was pleased to review your article and I have the following comment’s:
- first of all the sunject is interesting and without a lot of information on this particular situation.
- in my downloaded doc the flowchart is not visible
- knowing this results what new recommendations do you have
- please explain the limitation of your study
- English and punctuation are necessary
Title: A Novel Suturing Technique for Natural Tissue Repair in Cystocele Treatment
Version: 4 Date: 19 Jun 2024
Reviewer:  Carlos Antonio del Roy
Reviewer's report:
Your review should be constructive and focused on ensuring the results are accurately reported.
i like your tech , important contribuition for anterior pop .
R Study are nedded folowed to major time to avaluition an amnutaince outcames majors
Title: A Novel Suturing Technique for Natural Tissue Repair in Cystocele Treatment
Version: 4 Date: 19 Jul 2024
Reviewer's report:
Dear Authors,
Thank you very much for your submission. However it is not suit for publication.The reasons:
-There are very mistakes should be  corrected  with English language  editing system.
-The new methods steps were not correctly reported in the manuscript.You should define the
technique step by step with figures.
-Suturing starting with ATFP and ending other side ATFP will induce separation of pubovesical
fascia from ATFP.So it may cause of the new oncet paravaginal defect?
-The figures are not clear where is the suture starting , where is the end , knot? .
-The length of the bladder wall is not an measure method for  showing stength of bladder. So it
is a big mistake  for this study # think. Because bladder wall thikness increases  with infection,
cystitis, chronic bladder stones, ürinary tract endometriosis .. etc. #n additon  you should measure
the thicness preoperatively, but you did not.
- Figure 1 not about POPQ staging , it is a picture. chechk please.
-POPQ staging system uses points with +2,-2,0-1,+1,+3... etc. You wrote all points with only
number.So it isn't clear Aa /Ba/Ap/Bp:+2 +1, -1 or -2 ? it is completely different points as you
know.
Title: A Novel Suturing Technique for Natural Tissue Repair in Cystocele Treatment
Version: 4 Date: 31 Jul 2024
Reviewer's report:
To the authors:
Dear authors, congratulations for your study of a new suturing technique for a cystocele cure.
This modified natural tissue repair including a passage of the suture through the arcus tendineous
fascia pelvis bilaterally is suitable because traditional repairs are exposed to large recurrence
rates and the mesh reinforcement prohibited in many countries.
Surprisingly, this new technique is adapted from Rug Weaving technique utilized in pericardial
repair, since 2022. So, it’s a pity that the study was not prospective for a more rigorous
comparison with the conventional colporrhaphy. The short follow-up period (6 months) and the
limited number of patients (33 vs 32) are, of course, notable limitations, as mentioned by the
authors.
To use not absorbable sutures could be an interesting option.
In the abstract, could you mention “Modified Oxford Soring” instead MOS because the list of
abbreviations is on page 10!
In the introduction, are the references 5 and 8 very justified?
In the methods, the 6 last lines are not useful.
In the surgical technique, may be a cystoscopy more adequate than a bloody urine?
In the results, the Table 2 and 3 are not understandable for me, but I am not very qualified in
statistics! More, I don’t see the interest!
In the discussion, the paragraph about MOS and post-operative POP-Q is not very clear…
I agree totally with the conclusion.
May be the figure 2 could be enhanced by comments about each step?
Title: Prevalence and factors associated with unmet need for menstrual hygiene management in
six countries in Sub-Saharan Africa: a multilevel analysis
Version: 1 Date: 16 Apr 2024
Reviewer's report:
This paper looks at the correlates of unmet need for menstrual hygiene management in 6 African
countries using a multilevel regression analysis.
The paper found that the prevalence of unmet need for MHM was high among the uneducated
and multiparous women, those who reused MHM materials, practiced open defaecation and
lived in rural areas in all the six countries. The result also suggests heterogeneity in unmet needs
across countries.
The main contribution of the paper is the cross-national comparison which shows variation
across countries. The first level analysis suggests that this is related to socioeconomic status.
However, I think the paper can go a bit further to help explain what drives cross-country
variation. As it is country level variation has been captured by country level random effects.
As a robustness analysis, one can conjecture that country level inequality, or some measure of
human capital development explains these variations. The model can be adjusted so that country
level gini-coefficient and/or measure of gender gap can be employed as random slopes to see
if these explains cross country variations.
An alternative to this is to not adjust the model but use available macro statistics to paint a
picture of how the countries might be different in terms of contextual factors like inequality or
gender parity. Then this can be used to shed some light on the cross-country variations observed
in the discussions section. I think both approaches are good as long as it offers some explanation
on country level factors that drive these relationships. The importance of this is that it reveals
country level policy livers that can be used to address the problem.
Title: Explaining the burden of cultural factors on MS disease: a qualitative study of the
experiences of women with multiple sclerosis
Version: 0 Date: 11 Mar 2024
Reviewer's report:
In Tittle:
The word "women" should be added to the title of the article.
It is better to remove the word of 'worsening' from the title so that the title is completely neutral.
In the abstract:
In the background section, the purpose of the study is stated. It is better to write the background
of the subject and its importance.
The first 2 lines of the conclusion are repeated in the results. be deleted.
In Background
In stating the problem, it should be pointed out that previous studies about cultural factors and
their impact on MS have research gaps, which the present study aims to answer.
MS is among the topics that have been worked on a lot. Please, in this part, to justify the
importance and necessity of the study, the results of systematic reviews must be mentioned.
The results of several studies whose main concept under study is culture should be mentioned.
In Study aims
It is true that culture is a context dependent issue. But mentioning Iran in this part will reduce
the attractiveness of the subject for the international readers of the article. Respected authors
should note that with the expansion of communication and virtual space, many cultural issues
are common to all people of the world.
In Participants and recruitment
Please indicate the number of patients with MS to the center that was used as the research
environment.
In Results
It is better to only give the average age and refer the rest of the characteristics to the demographic
information table. In the current version, the information is repeated both in the text and in the
table.
In Main Category: Cultural tensions
Please note at the beginning of the discussion for each subgroup: What questions were asked,
to which the participants gave these answers?
In First Subcategory: Obligatory Communication with the Spouse's Family
In a qualitative study, the results of one or more interviews, as well as in the stage after the
formation of categories and themes, create a series of mental sparks for the qualitative researcher.
Based on the findings in this section, wouldn't it be better if the researchers interviewed single
women with MS or divorced women with MS and explained their experiences? Even I think it
would have been better to interview the spouses of women with MS and the personnel of the
MS center to enrich the obtained data.
Title: Explaining the burden of cultural factors on MS disease: a qualitative study of the
experiences of women with multiple sclerosis
Version: 2 Date: 26 Jun 2024
Reviewer:  Bonnie Bozorg
Reviewer's report:
Dear authors,
Thank your for your novel work but there are some few comments :
1. Please check out the format, for example figure and references font is diffrent from
manuscript.
2. some of the capital alphabet is not appropiatly used, forexample cultural in keywords.
3. I am not sure if the cultural tention is an appropriate term or not. Because some of the
subcategories are universal and it is not cultural base.
4. You discussed comminucation with spouse family, it is just related to spouse's family
relationship or other comminucation as well. So in this way the single group feel less burden.
Am I right? you have included the single but you have not discussed about it.
Overall I have enjoyed reading it and good luck.
Title: Explaining the burden of cultural factors on MS disease: a qualitative study of the
experiences of women with multiple sclerosis
Version: 2 Date: 27 Jun 2024
Reviewer:  Morteza Heidari
Reviewer's report:
Dear Authors
Your article was good but it needs considerable improvements to be acceptable for publication.
I added some comments and proposed some changes. Some of them are minor, but others are
major revisions especially in your introduction and discussion. I mean all your discussion needs
rewriting according to what I asked and thus, you must read your manuscript critically and revise
it. I hope the next time I receive the manuscript, I can approve it to be accepted.
With regards
Title: Explaining the burden of cultural factors on MS disease: a qualitative study of the
experiences of women with multiple sclerosis
Version: 2 Date: 29 Jun 2024
Reviewer's report:
Thanks to the author
It is a very valuable manuscript
The article was checked with the reviewer's comment and all items have been corrected
I will add a few
Introduction
It is better to report a statistic of the incidence of MS among women in Iran and the world
method
Report on how to analyze how many open codes were in the beginning and state the number
of codes in each step.
.
Title: Pelvic floor muscle training for female urinary incontinence: development of a programme
theory from a longitudinal qualitative case study
Version: 2 Date: 09 Jun 2024
Reviewer's report:
In this study, the authors address an important topic for women's health that is not well researched
on understood. The study is fairly large in size given the qualitative nature of the design.
Some comments for the authors to consider:
- The authors state that "The study investigated women’s experiences of the OPAL trial
interventions, PFMT alone and biofeedback-assisted PFMT, to: identify barriers and facilitators
to adherence in the short- and long-term; explain the process through which they influenced
adherence; and identify whether they differed between randomised groups." However, analysis
by randomisation group is not clearly presented in the manuscript. I suggest that these results
are presented and discussed.
- The information about recruiting 20 patients from each of the randomisation group should be
added to the abstract.
Title: Pelvic floor muscle training for female urinary incontinence: development of a programme
theory from a longitudinal qualitative case study
Version: 2 Date: 14 Jun 2024
Reviewer's report:
I read with great interest the manuscript, which falls within the aim of this Journal and offers
a high-quality overview of the topic.
Many points should be revised before considering this work for publication.
- An extensive correction of the English language is necessary.
- Many typos should be corrected.
- I find it interesting to include a reference to the new treatment strategies currently in use for
the treatment of urinary incontinence (see PMID: 28786873).
- The methods section should be completely revised.
- Inclusion/exclusion criteria should be better clarified by extending their description.
- Discussions can be expanded and improved by citing relevant articles about the use of
Ospemifene for the treatment of urinary symptoms (I suggest authors read and insert in
references  PMID: 30324854 ).
- The authors have not adequately highlighted the limitations of their study. It would be better
to explain these points.
Title: Pelvic floor muscle training for female urinary incontinence: development of a programme
theory from a longitudinal qualitative case study
Version: 2 Date: 18 Jun 2024
Reviewer:  Thomas Gray
Reviewer's report:
This is an excellent paper, the methods and design are clearly laid out and explained, the result
are clearly reported; including with helpful qualitative components from the semi structured
interviews. The discussion is clear and helpful and the paper adds important data and information
regarding this patient group. Strengths and limitations appropriately described and addressed. I
have no concerns or suggestions for revision here. Well done.
Title: Pelvic floor muscle training for female urinary incontinence: development of a programme
theory from a longitudinal qualitative case study
Version: 4 Date: 07 Jul 2024
Reviewer:  Thomas Gray
Reviewer's report:
I reviewed this at the first submission and was more than satisfied that it was acceptable for
publication.
I am concerned about the comments regarding English language from reviewer 2 as the English
is flawless. I work in the UK and this paper contains some appropriate reporting of Scottish
voices. I would not change this.
The paper is clearly acceptable for publication.
Title: HMOX1: A Pivotal Regulator of Prognosis and Immune Dynamics in Ovarian Cancer
Version: 4 Date: 16 Jul 2024
Reviewer's report:
Thank you for giving me the opportunity to review this interesting study "HMOX1: A Pivotal
Regulator of Prognosis and Immune Dynamics in Ovarian Cancer".
However, I have some comments and recommendations:
Comments:
Title: - Is appropriate for the content of the article.
Abstract:- Represents a suitable summary of the work.
Article content:- The methods and results have been well explained.
Conclusions:- Are justified on the basis of the study.
Recommendations:
Discussion:- Mention the limitations of the study.
References:- Stick to the format of the journal.
General:- Revise language, grammar and syntax.