Reviewer’ s report
Title: Clinical effects of switching from minodronate to denosumab treatment in patients with
postmenopausal osteoporosis: A retrospective study.
Version: 1Date: 19 Jan 2020
Reviewer: Luiz F. Baccaro
Reviewer's report:
Discussion Page 14 Line 1 - the sentence should read "patients could switch to denosumab…" and
not "patients may switch to denosumab"ConclusionsI believe that the conclusion is still veryemphatic based on the results of this study only, that has a very small sample of subjects and didnot reach the necessary sample size. Based only on their results, the authors cannot claim thatdenosumab is more effective in improving bone mass than continuous minodronate. They can onlysay that their results suggest this.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
YesDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
NoAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I recommend additional statistical reviewQuality of written English
Please indicate the quality of language in the manuscript:
Acceptable
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