Title: Analysis of global ovarian cancer disease burden and its changing trend from 1990 to 2021
Version: 0 Date: 06 Jan 2025
Reviewer:  Zaher Khazaei
Reviewer's report:
Strengths:
• Clear Structure: The introduction follows an organized outline that includes general
information about ovarian cancer, the importance of the topic, and references to historical data.
• Citing Data: Referring to credible statistics and reports such as GBD2019 and GBD2021 adds
to the credibility of the content and provides the reader with a clearer picture of the prevalence
and mortality associated with OC.
• Highlighting the Need: Explaining the necessity for updating data and examining risk factors
emphasizes the importance of continuing research in this field.
Areas for Improvement:
• Language and Text Fluency: In some sentences, the use of phrases may be somewhat complex.
Simplifying sentences and employing more accessible language can make the content easier for
general readers to understand.
• Topic Segmentation: The introduction could be divided into distinct sections to allow each part
to focus more on a specific aspect, such as a dedicated section on risk factors, a section about
the disease burden, and a section specifically on global data.
Use of Reliable Sources: The text clearly references credible data from the GBD platform and
the IHME institute, indicating the reliability and accuracy of the data.
Comprehensive Explanations: The methods of data collection and analysis are explained in
detail, allowing the reader to thoroughly understand the research process.
Age Standardization: Attention to the need for age standardization in comparisons helps to better
understand the burden of OC disease and enhances the validity of the results.
Thorough Analyses: The use of descriptive analyses and linear regression to examine the trend
of disease burden provides a comprehensive picture of the disease status.
Ethical Consideration: Reference to ethical approval and the lack of need for informed consent
from participants demonstrates adherence to ethical principles in research.
Discussion
The article provides a comprehensive and valid analysis of the trends in incidence and mortality
of ovarian cancer and examines the risk factors and global disparities in this regard. However,
improvements in language clarity, section separation, and limitation assessment could enhance
the quality and understanding of the article.
Conclusion
Strengths:
Accurate Summary: The conclusion effectively summarizes the key points of the research
and emphasizes the importance of GBD 2021 data in providing accurate information on the
incidence, mortality, and burden of ovarian cancer (OC).
Attention to Less Developed Regions: Mentioning the high burden of OC in less developed
regions and older populations indicates an awareness of global disparities and the need for
specific strategies in this area.
Relation to Lifestyle: Emphasizing the strong connection between OC and women’s lifestyles
and occupational exposures is an important point that can aid in identifying and reducing risk
factors.
Emphasis on Primary Prevention: The conclusion highlights the importance of primary
prevention and the need for national health resource allocation and targeted strategies, which
can help mitigate the disease burden.
Areas for Improvement:
Clarity and Simplicity of Language: Using simpler and clearer language could facilitate
understanding of the text. Some phrases may be complex for the general audience.
Practical Suggestions: Adding practical and specific suggestions regarding how to reduce the
burden of OC and prevention strategies could enrich the text.
Attention to Limitations: The conclusion could mention potential limitations of the research and
their impact on the findings, providing readers with a better understanding of the validity of
the results.