Reviewer ’s report  
 
Title: The influence of the rs1137101 genotypes of leptin recep tor gene on the demographic and 
metabolic profile of normal Saudi females and those suffering from polycystic ovarian syndrome  
 
Version: 2 Date: 14 Jan 2018  
 
Reviewer: Singh Rajender  
 
Reviewer's report:  
 
I found the study to be well conducted and a straight association study. This methods are 
appropriate and results are well presented. In the introduction, rath er than mentioning about the 
controversy among association studies, I would suggest the authors to mention that no study (if 
so) has been conducted on Saudi Arabian women. That would make a case for this investigation.  
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the autho rs. 
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the edito rs. 
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following quest ions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial com peting interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing in terests  
 
I agree t o the open peer review policy of the journal. I understan d that my name will be i ncluded 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
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I agree to the open peer review policy of the journal