JerMa88/BMC_Womens_Health_Peer_Reviews huggingface dataset:
Title: Analysis of factors associated with IUI pregnancy outcomes in elderly and young patients
Version: 0 Date: 08 Dec 2023
Reviewer's report:
The study "Analysis of factors associated with IUI pregnancy outcomes in elderly and young
patients" has limitations. These limitations are presented below;
1-Single Center: The fact that the study was conducted only at Changzhou Maternal and Child
Health Hospital may limit generalizability. With data obtained from different geographical
regions and different health centers, it is difficult to generalize the results as long as the data
are increased.
2-Retrospective Design: The retrospective design of the study may lead to uncontrolled variables
and information gaps in the data collection process. For prospective studies, it can provide more
control and evaluate cause-effect relationships more strongly.
3-Determination of Age Categories: The fact that the categories of old and young are determined
only according to age 35 and whether this classification is clinically or biologically meaningful
needs to be discussed with the literature. More specific criteria may be needed in determining
age groups.
4-Data Collection Method: The data collection method used in the study may affect the reliability
of the results obtained.
5- Other Factors: Lifestyle and genetic factors should be taken into consideration in the study.
These limitations significantly weaken the results of the study.  Researchers need to develop the
hypothesis by focusing on these factors.
Title: Analysis of factors associated with IUI pregnancy outcomes in elderly and young patients
Version: 0 Date: 15 Dec 2023
Reviewer:  Phuc Nhon Nguyen
Reviewer's report:
Dear authors,
Thank you for your great work. The study findings are not novel, but the study design and the
sample size are great. Some comment points needed to be addressed as below:
- Table 1, some baseline characteristics (smoking, alcohol, history of tubal surgery ) needed to
be provided.
- Besides BMI, waist-hip ratio and waist circumference are the important indexes (Butovskaya,
M., Sorokowska, A., Karwowski, M. et al. Waist-to-hip ratio, body-mass index, age and number
of children in seven traditional societies. Sci Rep 7, 1622 (2017). https://doi.org/10.1038/
s41598-017-01916-9) and (Li MC, Mínguez-Alarcón L, Arvizu M, et al. Waist circumference
in relation to outcomes of infertility treatment with assisted reproductive technologies. Am J
Obstet Gynecol. 2019;220(6):578.e1-578.e13. doi:10.1016/j.ajog.2019.02.013). Did the study
concern about waist-hip ratio and cholesterol level?
- AMH is strongly correlated to the patient age (Bedenk J, Vrta#nik-Bokal E, Virant-Klun I. The
role of anti-Müllerian hormone (AMH) in ovarian disease and infertility. J Assist Reprod Genet.
2020;37(1):89-100. doi:10.1007/s10815-019-01622-7). Did the study include this laboratory
test?
- PCOS (polycystic ovarian syndrome) is strongly associated with the female infertility
(Chelegahi AM, Ebrahimi SO, Reiisi S, Nezamnia M. A glance into the roles of microRNAs
(exosomal and non-exosomal) in polycystic ovary syndrome. Obstet Gynecol Sci. Published
online December 5, 2023. doi:10.5468/ogs.23193). Did this subject be excluded from the study?
- The technique was performed by the same investigator or different investigators?
- A study flowchart should be given.
- Although the p-value is significantly statistical (due to the large sample size), the value and
OR are not so different between 2 groups.
For example: The couple age in the pregnancy group is younger than the non-pregnancy group
(29.54 ± 2.62&29.99 ± 2.49,P < 0.001). The women age and BMI were related to the pregnancy
outcome of young women: 0.97 (95%CI, 0.89–0.97), (1.08 (95%CI, 1.01–1.06) ). These findings
are not significantly applied in the clinical management.
- Semen parameters according to WHO 2020 or WHO 2021 needed to be added (Boitrelle F,
Shah R, Saleh R, et al. The Sixth Edition of the WHO Manual for Human Semen Analysis: A
Critical Review and SWOT Analysis. Life (Basel). 2021;11(12):1368. Published 2021 Dec 9.
doi:10.3390/life11121368)
Best regards,
Title: Analysis of factors associated with IUI pregnancy outcomes in elderly and young patients
Version: 0 Date: 28 Dec 2023
Reviewer's report:
The authors present a retrospective analysis of factors influencing intrauterine insemination
pregnancy outcomes. The general idea behind the study is very interesting and important data
could be used for further research and establishing treatment guidelines.
However, several aspects must be clarified :
- firstly, I recommend a thorough review of English - the text is hard to follow and may confuse
the reader; a proficient or native English speaker could significantly improve the text;
- in the methods section the authors specify that patients were grouped based on age into 2
groups; since most patients likely underwent more than one cycle of IUI, please detail how
patients that transitioned from one age group to the other were handled in the study (did they
remain in the initial group? were they excluded from the study?)
- in the same line, inclusion and exclusion criteria should be mentioned;
- in the abstract, abbreviations should be explained at first use;
- in the results section, the authors talk about morphology rate - what do you mean? it should
be more clearly stated;
- in the analysis of the correlation to BMI, was this parameter used as a continuous or categorical
variable? and how many of the patients were underweight/supraponderal/obese? in the tables
the authors report mean values of the BMI that fall within the normal range for both pregnant
and non-pregnant groups, was a cut-off value found for the BMI?
- another aspect that would greatly improve the ease of read would be to more simply rephrase
the data from the results section, considering that most numbers and CI are already presented in
tables, the authors could just explain the results;
- in the results section there are several subsections detailing differences between patients that
obtained a pregnancy following IUI and those that did not; however a comparison between the
2 pre-set groups is not performed - was this not relevant for the study?
Title: Analysis of factors associated with IUI pregnancy outcomes in elderly and young patients
Version: 3 Date: 13 Jan 2024
Reviewer:  Phuc Nhon Nguyen
Reviewer's report:
Dear authors,
Thank  you again for  revising the manuscript.
Although some irreversible limitations regarding the missing data in a retrospective study, the
study contributed to the literature the clinical factors relating to failed of IUI method including
patient's age and BMI in Chinese population. The elderly women needed a higer number of
cycles of IUI compared to younger women.  The paper is well clarified and the presentation is
better now.
Congratulation on your interesting work.
Best regards,
Phuc Nhon Nguyen MD, MSc
Tu Du Hospital, Ho Chi Minh city, Vietam
Title: Analysis of factors associated with IUI pregnancy outcomes in elderly and young patients
Version: 3 Date: 26 Jan 2024
Reviewer's report:
Dear Editor
Academic English language corrections were made in the article titled "Analysis of factors
associated with IUI pregnancy outcomes in elderly and young patients".
refarasns are written correctly and up to date.
Requested corrections were made in tables and figures.
The publication is acceptable in this form.
Yours sincerely
Title: Prediction of recurrence-related factors for patients with early-stage cervical cancer
following radical hysterectomy and adjuvant radiotherapy
Version: 0 Date: 16 Nov 2023
Reviewer's report:
I read with great interest the manuscript, which falls within the aim of this Journal and offers
a high-quality overview of the topic.
Methodology is accurate and conclusions are supported by the data analysis. The tables and
figures are clear and interesting.
Although the manuscript can be considered already of high quality, I would suggest taking into
account the following minor recommendations:
- I suggest another round of language revision, in order to correct a few typos and improve
readability.
- I find it interesting to include a reference to the long-term outcomes of patients with cervical
cancer treated with a minimally-invasive approach compared to the "classic" open approach (see
PMID: 37149905).
- Although it is a retrospective analysis, inclusion/exclusion criteria should be better clarified
by extending their description.
- The authors have not adequately highlighted the strengths and limitations of their study. I
suggest better specifying these points.
Considering all these points, I think it could be of interest to the readers and, in my opinion, it
deserves the priority to be published after minor revisions.
Title: Health-related quality of life of postpartum women and associated factors in Dendi
district, West Shoa Zone, Oromia Region, Ethiopia: A community-based cross-sectional study
Version: 0 Date: 12 Oct 2023
Reviewer's report:
Review summary report
Title
Well done; but, if I were you, I would include ‘ Oromia Region’ to make the study area more
specific as it is a global report
Abstract
Background: ….the health-related quality of life of postpartum women remains overlooked…
You better report about PNC service in the community..
Method: from the district, you may go different steps to reach study unit; then for which step
you used simple random sampling?
Result: include 95% CI with the prevalence report
How did you count number of PNC visits? Who is the visitor (mother versus HCWs)?
Introduction
Well done though you overlooked about the PNC services…please have a say about it
Method
Study area: include number of Kebeles (urban and rural) the smallest administrative unit in the
district
Inclusion criteria….mother with still birth…..???
Exclusion criteria…mother with serious illness….as to me, even a mother minor illness could
report poor HRQL….report bias
Sampling technique: the steps used in the multi-stage sampling seems vague…please, make it
clear for the audience like the first, second, third sampling units….what if there are two mothers
in the same household?
Independent variables: replace household wealth index by asset variables because what you
collected originally was household asset variables not wealth index
Operational definition: what about report of original Likert scale?
Data collection procedure seems overlooked because it is a bit challenging in terms privacy and
confidential issue during interview in their house…please report how you did it
Please avoid waste words/phrases like majority of, half of, regarding….as they have no added
value other than congesting the document
What do you mean by ‘formal education’?
Figures are not self-explanatory and incorporate the following:
Figure 1 title lacks when….
Figure 2 and 3 lack where and when…
Discussion
First paragraph should report summary of the findings and avoid figures from the discussion
section and focus on the interpretation, synthesis and evaluation of the result; as well justification
has to consider relevance, feasibility and affordability.
Postnatal care service issue didn’t get except finding report because in the area where no PNC
service, report about HRQOL among mothers in the postnatal period is not convincing
Title: Health-related quality of life of postpartum women and associated factors in Dendi
district, West Shoa Zone, Oromia Region, Ethiopia: A community-based cross-sectional study
Version: 0 Date: 19 Dec 2023
Reviewer's report:
Comments and concerns
Abstract
• L29&30; re-write in  the form of past tense  ‘Therefore, this study aim aimed to assess health-
related quality of life of postpartum women and associated factors in Dendi district, West Shoa
Zone, Ethiopia’
• L39: …mean age of 44.02 (SD±10.4.) (SD±10.4)….
• L45; ….significant association with low health-related quality of life….
Methods
• L104: it is better to be consistent while reporting …..one primary hospital, seven health centers,
and 39  thirty nine health posts, which provide curative…
Result
• L299: better to cite the two figures with their appropriate locations in order not present figures
continuously without text descriptions above them
Concerns
• How many of the participants were interviewed during the early post-partum period especially
in the first week? And how did the authors manage the non-response rate?
Title: The Effects of synbiotic supplementation on blood pressure and other maternal outcomes
in pregnant mothers with mild preeclampsia: a triple-blinded randomized controlled trial
Version: 2 Date: 05 Nov 2023
Reviewer's report:
Dear authors! Your research looks innovative. The change in intestinal and bowel microbiota
is the reason for chronic inflammation.  Could you, kindly, find a recent meta-analysis on the
role of infection in the development of pre-eclampsia? I do not think so.  However, bacteria
vaginosis, UTI, and periodontal disease are known to be involved in the pathogenic scenario.
The main issue in pre-eclampsia prevention is the certain division into early- and late-onset pre-
eclampsia. Is your method universal for both contingent groups?  Could you describe in detail
the useful and harmful changes in gut microbiota? Is the effect of the proposed method of pre-
eclampsia dose-dependant?
Title: The Effects of synbiotic supplementation on blood pressure and other maternal outcomes
in pregnant mothers with mild preeclampsia: a triple-blinded randomized controlled trial
Version: 2 Date: 16 Nov 2023
Reviewer's report:
I read with great interest the manuscript, which falls within the aim of this Journal and offers
a high-quality overview of the topic.
Methodology is accurate and conclusions are supported by the data analysis. The tables and
figures are clear and interesting.
Although the manuscript can be considered already of high quality, I would suggest taking into
account the following minor recommendations:
- I suggest another round of language revision, in order to correct a few typos and improve
readability.
- Inclusion/exclusion criteria should be better clarified by extending their description.
- Discussions can be expanded and improved by citing relevant articles (I suggest authors to
read and insert in references the following article PMID: 37415612).
Title: The Effects of synbiotic supplementation on blood pressure and other maternal outcomes
in pregnant mothers with mild preeclampsia: a triple-blinded randomized controlled trial
Version: 2 Date: 22 Nov 2023
Reviewer:  Fatemeh Vakili
Reviewer's report:
I have reviewed the manuscript “The Effects of synbiotic supplementation on blood pressure
and other maternal outcomes in pregnant mothers with mild preeclampsia: a triple-blinded
randomized controlled trial”. The study was well-designed and some concerns should be
addressed before being accepted for publication.
1. The keywords should be based on MeSH system.
2. Please mention the prevalence of preeclampsia in Iran in the introduction.
3. Please provide more information about inclusion criteria. You said “mild preeclampsia” is
one inclusion criterion. It is important to explain how you diagnose mild preeclampsia”
4. Please provide more information about data collection tools.
5. Please discuss the impact of synbiotic supplementation on blood creatinine level.
6. This manuscript needs spell and grammatical corrections.
Title: The Effects of synbiotic supplementation on blood pressure and other maternal outcomes
in pregnant mothers with mild preeclampsia: a triple-blinded randomized controlled trial
Version: 2 Date: 28 Nov 2023
Reviewer's report:
1. The title mentioned mild preeclampsia but in the abstract mentioned moderate preeclampsia
-inconsistent criteria of selection
2. Results in abstract too general in summary and unclear.
3. The result segment mentioned that the primary outcome and showed that the blood pressure
between the intervention group and control group was significantly reduced. However it was
written as on the delivery day. – this may create bias of the reading as patient distribution seems
to be higher risk in the intervention group despite randomization. Furthermore the it would be
good to analyse the average blood pressure throughout the antenatal course
4. the intervention group had high participants given vitamin D as supplementation too as well
as having previous history of preeclampsia. – suggest the author to comment other confounding
factors that may also contribute to the lowering BP effect.
- Higher risk group may had been receiving earlier intervention with aspirin , vitamin D and
calcium which had numerous study to suggest the effectiveness, and now the researcher is adding
the symbiotic.
- Significant effect by symbiotic product can be direct or indirect effects – suggest to add this
in discussion
Title: The Effects of synbiotic supplementation on blood pressure and other maternal outcomes
in pregnant mothers with mild preeclampsia: a triple-blinded randomized controlled trial
Version: 4 Date: 06 Jan 2024
Reviewer's report:
Dear authors! I have read several publications on the role of intestinal and gut microbiota in
pre-eclampsia prevention before. I have found this paper fundamental. I have no more issues
or concerns.
Title: The Effects of synbiotic supplementation on blood pressure and other maternal outcomes
in pregnant mothers with mild preeclampsia: a triple-blinded randomized controlled trial
Version: 4 Date: 21 Jan 2024
Reviewer's report:
Thank you for going through the manuscript and the reviewers' points
In my honest opinion, the authors have responded satisfactorily to the reviewers’ criticisms.
The manuscript is well written and falls within the aim of this Journal.
Title: Lived Experiences of Refugee Women with Vaginal Fistula in Nakivale and Oruchinga
Refugee Settlements, Isingiro District, Uganda
Version: 1 Date: 20 Dec 2023
Reviewer's report:
MINOR REVISION
-          The paper is too long and should be more concise. The text is often long-winded and
repetitive at several points, so that the reader  loses focus on the main themes.
-          A scientific article must present the data through a pragmatic and precise method.  The
lived experiences are very interesting, but they lengthen the text and risk causing confusion. It
would be more useful to collect all the testimonies in an additional file.
-          Several partecipants  reported rape as the causes of their vaginal fistula. In a non–
war zone the cause of fistula is rarely related to sexual abuse, but it more frequently it can
be determined by post-coital laceration.  Therefore, future research should investigate more
specifically whether even in the African population the extremity of age and the execution of
specific sexual positions are risk factors of vaginal trauma as recently reported in the literature
(DOI: 10.3390/ijerph18189746).
-          In the text, three different experiences are repeated ( first repetition:  353-360; 368-375;
second repetition: 378-381;384-387; third repetition : 405-408;572-575). You need to correct
the paper  by deleting the wrong parts.
Title: Lived Experiences of Refugee Women with Vaginal Fistula in Nakivale and Oruchinga
Refugee Settlements, Isingiro District, Uganda
Version: 1 Date: 22 Dec 2023
Reviewer's report:
Dear Authors, Thank you to allow to me to review this interesting manuscript. However, even
if interesting, the manuscript should be restructured. The paper should be more concise. The
lived experiences are interesting but need to be more shorts or presented in an additional file.
Furthermore in the text there are repetitions of the experiences.  There are some typos that should
be corrected. Please revise and reduce the manuscript
Title: Influence of sociodemographic and obstetric factors on maternal mortality in Brazil from
2011 to 2021
Version: 0 Date: 28 Dec 2023
Reviewer's report:
The work and scientific effort carried out in the analysis of maternal mortality data is valuable.
It is recommend giving consistency and methodological coherence to the work.
The methological coherence could be achieved by: a) clearly specifying each variable and its
definition; b) providing a clear methodology outlining the steps taken; c) justifying the choice
and relevance of each statistical analysis conducted; d) providing better clarification for the title
and footnotes for each table; e) incorporating databases and tables that were not included in the
manuscript as supplementary material.
Methodologically, it is confusing how they evaluate the impact of sociodemographic factors on
direct or indirect obstetric causes.  It is recommended to analyze different robust methods to
perform these analyses.
Title: Influence of sociodemographic and obstetric factors on maternal mortality in Brazil from
2011 to 2021
Version: 0 Date: 09 Jan 2024
Reviewer's report:
Dear Editor.
Thank you for the opportunity to evaluate the study in question.
The main objective of the study was to investigate the influence of sociodemographic factors in
predicting obstetric mortality during pregnancy, childbirth and postpartum in Brazil from 2011
to 2021.
This is an important topic for women's health and public health.
The article needs some clarification for publication:
The title does not reflect what was found. I suggest changing it to: "Influence of
sociodemographic and obstetric factors on maternal mortality in Brazil from 2011 to 2021"
In the summary, the objective is different from that presented in the text, I suggest standardizing.
The summary results do not present what was found, they are superficial.
The introduction is well written and concise.
The methods need clarification, especially some points, the authors are using crude maternal
mortality rates.
Rate correction factors were used.
See the articles below:
Laurenti R, Jorge MHP de M, Gotlieb SLD. Maternal mortality in Brazilian capitals:
some characteristics and estimation of an adjustment factor. Rev bras epidemiol [Internet].
2004Dec;7(4):449–60. Available from: https://doi.org/10.1590/S1415-790X2004000400008
Luizaga Carolina Terra de Moraes, Gotlieb Sabina Léa Davidson, Jorge Maria
Helena Prado de Mello, Laurenti Ruy. Maternal deaths: revision of the
correction factor for official data. Epidemiol. Serv. Health [Internet]. 2010 Mar
[cited 2024 Jan 09] ; 19(1): 8-15. Available at: http://scielo.iec.gov.br/scielo.php?
script=sci_arttext&pid=S1679-49742010000100002&lng=pt. http://dx.doi.org/10.5123/
S1679-49742010000100002.
Silva BGC da, Lima NP, Silva SG da, Antúnez SF, Seerig LM, Restrepo-Méndez MC,
et al.. Maternal mortality in Brazil from 2001 to 2012: temporal trends and regional
differences. Rev bras epidemiol [Internet]. 2016Jul;19(3):484–93. Available from: https://
doi.org/10.1590/1980-5497201600030002
I suggest considering the correction factor.
Another important point, when including years in the regressions, how did they treat the
correlation from time series?
I suggest applying models that consider temporal correlation over the years. Furthermore, the
rates need to be smoothed to reduce the heterogeneity of the variance of the residuals arising
from the time series regression analysis.
This is not mentioned if it was done.
After these changes, I suggest changing the results and the discussion.
Sincerely.