Reviewer’s report
Title: 
Quality of Life and its Related Factors in 
Women with Substance Use
Disorders Referring to Substance 
Abuse 
Treatment Centers
Version: 
4 
Date: 
16 Nov 2020
Reviewer's report:
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Thank you for responding to the comments and criticisms I previously offered.
My main comment is that this needs to have some editing by an English speaker.
I hesitate to make this suggestion as my ability to write in a second language is
nowhere near as accomplished as yours - but for an international audience I think
it needs someone to read through and make the document more readable - again
my apologies because your English is better than my capability to speak or write
in another language.
Some other smaller points
Line 31 in the abstract - I think you mean "questions" not questioner
in the background section - why is tattooing a problem? Its unclear why its listed
in adverse outcomes of drug use - I can guess but some indication needs to be
VERY briefly given 
On the second page of the discussion you indicated the need for specific QoL
interventions for Crack users citing US research - but as you indicate earlier, it
appears "Crack" in Iran differs from that in US. So this doesnt follow and why
specifically this group - QoL issues occur for most service consumers
You use terms like substance use, substance use disorders and substance abuse
disorders interchangeably - the one most commonly used is substance use
disorders - I suggest you use this consistently.
Id really like to see in the discussion/conclusion what your study leads to in
terms of specific indicated interventions for women with SUD in Iran.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
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