Reviewer ’s report  
 
Title: Rare genital malformations in women's health research: sociodemographic, regional, and 
disease related characteristics of patients with Mayer -Rokitansky -Küster -Hauser syndrome  
 
Version: 1 Date: 30 Sep 2019  
 
Reviewer: Karina Kapczuk  
 
Reviewer's report : 
 
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In my opinion the authors shouldn't define MRKHS as the congenital absence of the up per two 
thirds of the vagina and the uterus. Better term is aplasia or hypoplasia of the uterus and the 
vagina.  
 
Who was considered in the family history? 1st,2nd, 3rd degree relatives?  
In the first part of the discussion the authors repeated the data pre sented in the background (for 
example: The MRKHS affects 1:4000 -5000 female newborns every year) and in the results. This 
in unnecessary.  The authors like to point to differences that are not statistically significant 
thought it means no differences.  
Page 9: The authors stated that the long period between the diagnosis and the surgery provides 
evidence of insufficient psychosocial support? Why? Do analysis of interviews with respondents 
suggest it?   
 
Page 10: Are you sure that the MRKHS is the most common  malformations of the female 
genitals?  
 
The study group included patients who underwent surgery between 2008 and 2012 (as indicated 
in the abstract and the aims). The youngest patient (according to the data included in the table 2) 
was diagnosed at the age  of 2 years  and the maximum time between diagnosis and surgery was 
30 months. Where is the error? Please check the data in the tables.  
Conisdering the data shown, the conclusions in the abstract are more adequate than in the text. 
The present study do no t analyze the needs and the preferences of women with MRKHS.  
 
Are the  methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
 
Does the work include the necessary controls?  
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Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
No 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscr ipt: 
 
Acceptable  
 
 
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