Review for 10.1186/s12876-019-1084-z (2019)

Reviewer’ s report
Title: Candidate Single Nucleotide Polymorphisms of Irritable Bowel Syndrome: A Systemic
Review and Meta-analysis
Version: 0Date: 15 Jul 2019
Reviewer: Humberto Jijon
Reviewer's report:
Dear authors: I believe the methodology and conclusions are adequate, however, I feel that the
manuscript has significant grammatical errors that need to be addressed in order for thismanuscript to be published. In addition, although the association of TNSF15 polymorphisms withIBS is well entrenched in the literature, I believe a discussion of why other "novel" SNPs did notmake the final analysis is warranted, in particular genes associated with channel function. Is thisbecause these SNPs have not been reported on more than 3 occasions? In this regard, specialattention and discussion of the GWAS meta-analysis form Bonfiglio et al., 2018 is needed.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Unable to assessDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I recommend additional statistical reviewQuality of written English
Please indicate the quality of language in the manuscript:
Not suitable for publication unless extensively edited
Declaration of competing interests
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