Review for 10.1186/s12876-022-02126-y (2022)

Reviewer’s report
Title: 
Association between plasma level of superoxide dismutase and survival of
patients with acute-on-chronic liver failure
Version: 
1 
Date: 
07 Nov 2021
Reviewer's report:
1. According to methods section, all patients received blood tests at admission
and 14 days after admission. But in the result, all comparison was done by the
blood test result at admission. Could you show the result of SOD level on 14
days after admission and compare them with SOD level at admission? I wonder
if SOD level changed as time goes on. I think this point is crucial to discriminate
SOD as the substitute of disease severity or just the result of damage of
hepatocytes. If the level of SOD varied as time passes, could it still be used as
reliable marker for disease severity? Or at which time point, it could be a reliable
marker?
2.In Table 1, p value of each item should be added for comparison.
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