Review for 10.1186/s12876-021-01950-y (2021)

Reviewer’s report
Title: 
Long term survival of a patient with microsatellite stable refractory
colorectal cancer with regorafenib and PD-1 inhibitor sintilimab – A Case
Report and Review of Literature
Version: 
0 
Date: 
26 Jul 2021
Reviewer's report:
Interesting Case Report but in need of some changes.
The Background must be improved by adding both in the Abstract and in the
Introduction, a brief introduction of the topic under consideration.
Furthermore, the aim of the study is unclear, it needs to be better explained.
Professional editing of English is required.
The last sentence of the Introduction should be removed ("This is the first such
report demonstrating a favorable prognosis of regorafenib combined with PD-1
antibody in a patient with microsatellite stable CRC in China", line 110-112).
Please, add the Care Guidelines for Case Report. You can find them on the
Equator Network, https://www.equator-network.org/reporting-guidelines/care/.
Both the Discussion and the Conclusions need to be better focused and a
comparison with the results already present in the literature is necessary.
The addition of study limits and its clinical impact is essential.
In conclusion, please consider these articles in the Introduction:
The prognostic value of KRAS and BRAF in stage I-III colorectal cancer. A
systematic review. Ann Ital Chir. 2019; 90: 127-137 ; 
Predictive and prognostic biomarkers in colorectal cancer: A systematic review
of recent advances and challenges. Biomed Pharmacother. 2017 Mar; 87: 8-19.
doi: 10.1016 / j.biopha.2016.12.064 ;
Colorectal cancer: from prevention to personalized medicine. World J
Gastroenterol. 2014 Jun 14; 20 (22): 6786-808. doi: 10.3748 / wjg.v20.i22.6786 .
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
No
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes