Review for 10.1186/s12876-020-01498-3 (2020)

Reviewer’s report
Title: 
Distinct clinicopathological differences between early gastric cardiac and
non-cardiac carcinomas: A single-center retrospective study of 329 radical
resection cases
Version: 
0 
Date: 
04 Jun 2020
Reviewer's report:
This manuscript by Wang et al was a single centre study looking at the
clinicopathological differences between early gastric cardiac and non-cardiac
carcinomas. The authors acknowledge and discuss many of the limitations
associated with the study such as a relatively small sample size and the fact that
it was based on samples collected at a single centre.
-The authors touch on potential differences based on geographical locations, I
think expanding a little more on this in the discussion would be beneficial
-The authors briefly mention how the data may relate to the CIN and GS
molecular subtypes. Do the authors know the EBV and MSI status of the
tumours? These may be interesting.
-Similarly do the authors know the CDH1 status of these tumours? These are
more likely to be associated with the GS subtype.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the
authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you
recommend an additional statistical review?
If an additional statistical review is recommended, please specify what aspects
require further assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Acceptable
Declaration of competing interests
Please complete a declaration of competing interests, considering the following
questions:
1
. 
Have you in the past five years received reimbursements, fees, funding, or
salary from an organisation that may in any way gain or lose financially
from the publication of this manuscript, either now or in the future?
2
. 
Do you hold any stocks or shares in an organisation that may in any way
gain or lose financially from the publication of this manuscript, either now
or in the future?
3
. 
Do you hold or are you currently applying for any patents relating to the
content of the manuscript?
4
. 
Have you received reimbursements, fees, funding, or salary from an
organization that holds or has applied for patents relating to the content of
the manuscript?
5
. 
Do you have any other financial competing interests?
6
. 
Do you have any non-financial competing interests in relation to this
paper?
If you can answer no to all of the above, write 'I declare that I have no competing
interests' below. If your reply is yes to any, please give details below.
I declare that I have no competing interests
Reviewer Publication Consent.
 I agree for my report to be made available
under an Open Access Creative Commons CC-BY License (
http://creativecommons.org/licenses/by/4.0
) if this manuscript is accepted for
publication. Any comments that I do not wish to be included in the published
report have been included as confidential comments to the editor, which will not
be published.
If you are not happy for us to publish this report, please contact the editorial
office before completing the review.
If you wish, you can include your name in your published report. Please note
you must decide whether to include your name at the start of the process and
confirm this decision whenever prompted. If you change your decision later, we
will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please 
do not
 publish my name
with my report. (default)