Review for 10.1186/s12876-022-02454-z (2022)

Reviewer’s report
Title: 
Natural history of intracholecystic papillary neoplasm (ICPN); a rare case
of ICPN whose natural history was closely followed by ultrasound.
Version: 
0 
Date: 
02 Mar 2022
Reviewer's report:
The authors reported a case of ICPN that increased in size in 2 years by follow-
up abdominal US.
The disease concept of ICPN is relatively new and the definition of
ICPN is not clearly established.
Probably, some cases are reported as "papillary adenocarcinoma" so far.So the
rarity of this paper is unknownbut an interesting case report.
I would like to request the following points to be revised.
1) 
Preoperative diagnosisDifferential diagnosis :
Did the authors not enforce Doppler US or EUS?
As a preoperative diagnosis, the authors considered cholesterol polyp or
pyloric type adenoma, but refer to the US and enhanced CT after 2years follow
up, 
gallbladder cancer also should be differentiated. It seems to be a slight
thickening of the gallbladder wall.
Operative procedure, Intraoperative rapid histological diagnosis:
Maybe because the authors did not suspect gallbladder cancer, Laparoscopic
cholecystectomy (LC) was performed.
I think it should be stated the choice of LC. And it should be 
stated whether the
intraoperative rapid histological diagnosis was done or not.
Pathological Diagnosis: 
The authors diagnosed the tumor as gastric type ICPN, but I think pyloric gland
adenoma should be strictly differentiated histopathologically.
Have you thought about immunostaining of β-Catenin?
In pyloric gland adenoma of GB, it usually strongly express MUC6 and 
β
-
Catenin.
On the other hand, ICPN is negative for β-Catenin.
Minor Comments
The authors described 
"ICPN with high-grade atypia" in Case presentation section,
but according to the 5th edition of the WHO tumor classification,
It is described as " ICPN with high-grade intraepithelial neoplasia.
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