Review for 10.1186/s12876-021-01754-0 (2021)

Reviewer’s report
Title: 
Microbial Diversity Following Antibiotic Treatment of Clostridioides
difficile Infection
Version: 
0 
Date: 
29 Jan 2021
Reviewer's report:
This study examine the correlation between antibiotic treatment received prior to
C. difficile infection onset and patient gut microbiota. The author concluded the
number of different antibiotics administered has a major impact on gut
microbiome. Although study design is appropriate and manuscript is written
well, the results don't add much to the already known literature regarding
decreased microbial diversity with antibiotics.
I have following comments
-Was there any different between microbiome based on episodes of CDI?
-would be interesting to examine the relation between doses and duration of
antibiotics and its impact on microbiome
-Do we have follow up for these patients? how many had a recurrence?
- Was there any correlation between severity and decreased microbial diversity
- What was the time frame for antibiotics given particularly in patients who
received 4 different classes of antibiotics
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Is the study design appropriate to answer the research question (including the use
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