Review for 10.1186/s12876-021-01738-0 (2021)

Reviewer’s report
Title: 
Linaclotide for the treatment of refractory lower bowel manifestations of
systemic sclerosis
Version: 
1 
Date: 
11 Feb 2021
Reviewer's report:
The article has significantly improved in its general form and the authors have
fully satisfied my previous observations.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
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Yes
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from apparent manipulation?
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