Review for 10.1186/s12876-022-02170-8 (2022)

Reviewer’s report
Title: 
Protein-losing gastroenteropathy complicated with asymptomatic primary
biliary cholangitis, refractory to immunosuppressant, and improved by
Helicobacter pylori eradication: A case report
Version: 
0 
Date: 
09 Sep 2021
Reviewer's report:
This is a very interesting case report.
Consider the following points:
1) The text of the case report is too long. Moreover, most of them are introduced
before treatment. Since it is important whether or not the eradication therapy
really improved, I would like you to comment mainly on changes in the patient's
condition during the course of treatment.
2) Most of the discussions are about other diseases. The issue is the relationship
between Helicobacter pylori eradication and PLGE. We recommend that you
summarize it briefly as a whole.
3) There's been a lot of Discussion, but in the end you should clarify whether
you think this PLGE was caused by H. pylori or by PBC or SjS.
4) Why did cecum lymphatic hyperplasia improve after eradication? If you think
it's an important finding, please discuss it. 
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
No
Is the presentation of the work clear?
No
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes