Review for 10.1186/s12876-019-1113-y (2019)

Reviewer’ s report
Title: Three cases of histologically proven hepatic epithelioid hemangioendothelioma evaluated
using a second-generation microbubble contrast medium in ultrasonography: case reports
Version: 1Date: 27 Oct 2019
Reviewer: Xingshun Qi
Reviewer's report:
The authors tried their best to do a reply to the reviewers' comments. However, as a case report,
this paper has its own limitation. The findings from a case report might be difficult for evaluatingthe diagnostic accuracy of a new imaging test. As known, a diagnostic test study needs positiveand negative cases as compared to the golden standard and finally made a ROC curve. Of course,the disease is rare. In conclusion, despite I recommend a postivie decision, the conclusions shouldbe greatly toned down.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
NoDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
No
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Unable to assessAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
Not relevant to this manuscriptQuality of written English
Please indicate the quality of language in the manuscript:
Acceptable
Declaration of competing interests
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