Review for 10.1186/s12876-021-01759-9 (2021)

Reviewer’s report
Title: 
Colorectal cancer screening using a stool DNA-based SDC2 methylation
test: a multicenter, prospective trial
Version: 
0 
Date: 
21 Nov 2020
Reviewer's report:
-Add the uniqueness of this study.
-Add more on the different screening methods of rectal Ca in the introduction
-Discus role of imaging in colorectal tumor using these refs
-Abd-El Khalek Abd-ALRazek A, Fahmy DM. Diagnostic Value of Diffusion-
Weighted Imaging and Apparent Diffusion Coefficient in Assessment of the
Activity of Crohn 
Disease: 1.5 or 3 T. J Comput Assist Tomogr 2018;42:688-
696.
-Abdel Razek AA, Abu Zeid MM, Bilal M, Abdel Wahab NM. Virtual CT
colonoscopy versus conventional colonoscopy: a prospective study.
Hepatogastroenterology 2005;52:1698-702.
-English language correction through the manuscript
-Discuss the merits and limitations of the technique applied
-Update of references 
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Is the study design appropriate to answer the research question (including the use
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