Review for 10.1186/s12876-022-02618-x (2023)

Reviewer’s report
Title: 
Establishment and Evaluation of an Early Prediction Model of
Hepatorenal Syndrome in Patients with Decompensated Hepatitis B Cirrhosis
Version: 
0 
Date: 
18 Jun 2022
Reviewer's report:
In this study, the authors identified that serum biomarkers hemoglobin, total
bilirubin, and creatinine can be used as independent early predictors of
hepatorenal syndrome (HRS) in patients with decompensated hepatitis B
cirrhosis. Since the authors highlighted "early prediction" of HRS for the sake of
possible early intervention, the study subjects were supposed to be those with
decompensated hepatitis B cirrhosis at risk of developing HRS; in other words,
for the prediction model setup, the clinical data before fitting the criteria of HRS
might be considered to use, and then early prediction and intervention might be
possible.
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