Review for 10.1186/s12876-022-02455-y (2022)

Reviewer’s report
Title: 
Concomitant Guillain–Barré Syndrome in a Young Sri Lankan Male with
Severe Ulcerative Colitis
Version: 
1 
Date: 
09 Dec 2021
Reviewer's report:
The authors presented a patient with ulcerative colitis who developed Guillain-
Barré Syndrome as a rare EIM of UC. the case is well documented, but some
points deserve further clarification.
"There had been a marked unintentional weight loss of almost twenty kilograms
within a month." Please provide the percentage of weight loss.
"He had elevated inflammatory markers with very low albumin." Please provide
these values and the normal range. 
Please clarify why the patient started treatment with azathioprine and later the
medication was switched to tofacitinib. What was the indication/rationale for
changing the medication?
Please discuss the risks and benefits of using other therapeutic (biologic therapy)
options with different mechanisms of action than anti-TNF in this case, such as
vedolizumab and ustekinumab, both approved for use in ulcerative colitis. Please
detail the mechanisms of action and the risks with the development of
neurological manifestations such as Guillain-Barré. 
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
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Yes
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