Review for 10.1186/s12876-022-02417-4 (2022)

Reviewer’s report
Title: 
Epstein-Barr virus-associated gastric adenosquamous carcinoma with
concurrent gastric carcinoma with lymphoid stroma: A case report and review of
the literature
Version: 
1 
Date: 
23 Apr 2022
Reviewer's report:
The authors reported the first case of gastric cancer with EBV infection detected
in both adenosquamous carcinoma and gastric carcinoma with lymphoid stroma.
They collected the patient's pathological data in detail and conducted detailed
discussion and analysis. The conclusions remind the clinicians and pathologists
should recognize the presence of such a tumor. However, there are two points
that still need to be further explained 
1. How is the sampling method of early gastric cancer? In general, it always
takes full-thickness tumor samples in total gastrectomy specimens, not just
mucosa (P3, L17 and L35).
2. The EGFR signaling pathway is a tyrosine kinase receptor pathway, it is a
common pathway in cancers. It should be cautious to make this conclusion only
with the single immunohistochemical results of EGFR (P2, L17).
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
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