Review for 10.1186/s12876-021-02069-w (2021)

Reviewer’s report
Title: 
The first two cases of posterior reversible encephalopathy syndrome
(PRES) secondary to conventional transcatheter arterial chemoembolization of
hepatocellular carcinoma: case report
Version: 
1 
Date: 
14 Nov 2021
Reviewer's report:
The case report is interesting and well described.
I have the following suggestions:
1) The authors correctly state that the side effect could be due (at least in part) to
the cytotoxic effect of doxorubicin. Therefore, we may postulate that use of
bland embolization (TAE) could avoid or at least decrease the risk of these
complications. Authors should comment on this and cite the recent meta-analysis
comparing TACE vs TAE (PMID: 28588882).
2) I would invite the authors to search in the MAUDE database if a similar case
was reported. It is an open access platform where post-marketing experience
with a specific drug/device is registered.
3) DO the authors think that the same risk would have been possible also with
DEB-TACE?
4) Could the dose of the drug have a role in the occurrence of this complication?
5) The eventual role of concomitant medications (for other diseases) should be
commented by the authors
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