Review for 10.1186/s12876-021-01758-w (2021)

Reviewer’s report
Title: 
Case Report: Restrictive Diet in a Patient with Irritable Bowel Syndrome
Leading to Wernicke Encephalopathy
Version: 
2 
Date: 
25 Jan 2021
Reviewer's report:
Thank you for the opportunity for reviewing this interesting case report.
The authors report an important, potentially life-threatening neurological
disorder, which was diagnosed and managed successfully by their team.
The case report is worth publishing, but I have some suggestion to be considered
and questions to be answered:
Comments to the authors:
„Case presentation" section: 
Could you explain what „extensive work up" means in this specific case? Were
other causes of chronic malabsorption, e.g. coeliac disease, ruled out?
What are the facts supporting the diagnosis of SIBO in this case?
What about other diet-related causes of thiamine deficiency in this case (e.g.
excessive tea and coffee consumption can also cause thiamine deficiency due to
high tiaminase content)
What about alcohol consumption is this case?
„Discussion" section:
I think, this section needs further expansion about the disease (prevalence,
diagnostic criteria, differential diagnosis).
The cause-effect relationship between the mentioned diseases and conditions
should be clarified (IBS-SIBO-thiamin deficiency-restrictive diet). Particularly:
Is SIBO the cause or consequence of thiamin deficiency?
What is your nutrition advice to patients on a restrictive diet?
To conclude, I suggest minor revision.
I suggest reporting the case report according to CARE guideline.
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