Review for 10.1186/s12876-022-02411-w (2022)

Reviewer’s report
Title: 
Study protocol of a single-arm phase 2 study evaluating the preventive
effect of topical hydrocortisone for capecitabine-induced hand-foot syndrome in
colorectal cancer patients receiving adjuvant chemotherapy with capecitabine
plus oxaliplatin (T-CRACC study)
Version: 
0 
Date: 
24 May 2022
Reviewer's report:
Have you considered other interventions such as an education intervention
A non randomised study will not add to our knowledge
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
No
Are the methods sufficiently described to allow the study to be repeated?
No
Is the use of statistics and treatment of uncertainties appropriate?
No
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes