Review for 10.1186/s12876-020-01468-9 (2020)

Reviewer’ s report
Title: Massive iron overload and acute-on-chronic liver failure in a patient with Diamond–
Blackfan anaemia: a case report.
Version: 0Date: 02 Aug 2020
Reviewer's report:
In this case report, Dr. Guilherme et al. demonstrated detailed histological changes of multiple
organs in a Diamond-Blackfan anemia patient who suffered from the complications of massiveiron deposition. The manuscript is well written, and the structure is well constructed. However,there are still some comments listed as following:1. Is there any data showing mean survival age for patients with Diamond-Blackfan anemia?
2.Since massive iron deposition is inevitable for most patients with Diamond-Blackfan anemia, do
you think her death is also inevitable? If the answer is no, how to prevent it?
3.Do you think liver transplantation if helpful for her?
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NoDeclaration of competing interests
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Is the study design appropriate to answer the research question (including the use of appropriate
controls), and are the conclusions supported by the evidence presented?
YesAre the methods sufficiently described to allow the study to be repeated?YesIs the use of statistics and treatment of uncertainties appropriate?YesIs the presentation of the work clear?YesAre the images in this manuscript (including electrophoretic gels and blots) free from apparent
manipulation?
Yes