Review for 10.1186/s12876-020-01523-5 (2020)

Reviewer’s report
Title: 
Adding ursodeoxycholic acid to the endoscopic treatment and common
bile duct stenting for large and multiple biliary stones: will it improve the
outcomes?
Version: 
0 
Date: 
08 Oct 2020
Reviewer's report:
If this is the first RCT of stenting and UDCA combination therapy for CBD
stone, I think it is worth of publishing.
Major
1. How much is the additional effect of this study compared to the past studies of
UDCA alone or biliary stenting alone? please describe them in discussion.
2. How did you set UDCA 300mg/day and 8 weeks? Please describe the reason
to set the conditions and cite the referenced articles in Methods.
3. Are there any RCTs of UDCA and stenting combination therapy? If not, you
should specify that this is the first paper, and if so, what is different from these
articles and what is new of this study.
Minor
4. Please add units to Table 2.
5. If you know the number of CBD stones, why not add them to Table 2?
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
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