Review for 10.1186/s12876-021-01632-9 (2021)

Reviewer’s report
Title: 
Fatal acute-on-chronic liver failure in amiodarone-related steatohepatitis:
A case report
Version: 
0 
Date: 
14 Dec 2020
Reviewer's report:
The authors report a case of acute liver failure with fatal outcome in a patient
with metabolic syndrome, CVD, and amiodarone treatment with subsequent
development of liver abscesses.
1) Please provide a more detailed description of the patients liver function
before, ad upon transmission. This includes liver enzymes, albumin, INR and
bilrubine.
2) Please provide information if a hepatopathy screening was negative ,incl viral
hepatitis, auto-immune and hereditary liver disease.
3) Please provide the patients liver fibrosis status before admission (Fibroscan,
biopsy, or e.g. APRI score).
4) Please discuss the following: if the hepatopathy panel (s. above) came out
negative, then the patient was most likely suffering from steatohepatitis related to
her metabolic syndrome/insuline resistance.
On top of this, she was added amiodarone which led to additonal hepatotoxicity.
5) Please provide information on the patients alcohol consumption.
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