Review for 10.1186/s12876-021-01766-w (2021)

Reviewer’s report
Title: 
Hybrid endoscopic submucosal dissection – An alternative resection
modality for large laterally spreading tumors in the cecum?
Version: 
0 
Date: 
31 Dec 2020
Reviewer's report:
The authors reported a series of hybrid ESD comparing to ESD in lateral
spreading tumor size > 2 cm at cecum. Please find my comments below. 
1. In the abstract, the number in each group should be mentioned. 
2. In the abstract, the sentence "The en bloc resection rate (81.5% vs. 77.1%, P
=0.677), complete resection rate (81.5% vs. 71.4%, P = 0.359), and
complications rate (25.9% vs. 17.2%, P = 0.710) were similar between the hybrid
and ESD groups, respectively" is likely to be incorrect. ESD should come before
hybrid ESD. 
3. Please provide information regarding who did the procedures. How many
cases performed before the study inclusion? Any trainees involved? How many? 
4. Please provide information regarding the period of patients included. Was the
distribution of ESD and hybrid ESD cases equal in each period of time? The
experience of endoscopists and technology of equipment should affect the
outcomes of procedures. 
5. For characteristics of patients in lesions in each group, please provide BMI of
patients, degree of submucosal fibrosis. 
6. The nondifference in outcomes of hybrid ESD and ESD could be due to
inadequate power because there was a trend that complete resection was found
more in the ESD group. 
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
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