Review for 10.1186/s12876-021-01707-7 (2021)

Reviewer’s report
Title: 
Gene Expression Profiling of Inflammatory Cytokines in Esophageal
Biopsies of Different Phenotypes of Gastroesophageal Reflux Disease: a cross-
sectional study
Version: 
1 
Date: 
07 Oct 2020
Reviewer's report:
The authors re-analyzed the data changing the classification of reflux
phenotypes. As a result, the data became more interesting. 
Minor comment:
1. The manuscript needs English proof reading.
2. Line 216-218, page9-10. Please modify the statement to clarify the
comparison made in the study
3. Line 251, page 11. What does 0.001 mean? p<0.001? The similar type of
numbers were scattered in the manuscript.
4. Table 3. "Percentage of pH <4.2% in 24-hour pH-monitoring in the non-
erosive
endoscopic phenotype and controls" does not make sense. Acid exposure time in
24-hour… would be fine.
5. Line 260, 261, page 11. Interleukin should be abbreviated to IL, not Il. This
type of error was also seen in other parts of the manuscript.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
No
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes