Review for 10.1186/s12876-020-01424-7 (2020)

Reviewer’ s report
Title: Gastropathy associated with lanthanum phosphate deposition that was endoscopically
tracked for 3 years. : a case report
Version: 1Date: 30 Mar 2020
Reviewer: Yoshinobu Hirose
Reviewer's report:
The authors described a novel case regarding gastropathy associated with lanthanum phosphate
deposition that was endoscopically tracked for 3 years. Recently, the gastropathy in dialysedpatients with administration of lanthanum has been reported more often. However, the trackingdata of endoscopic findings on an individual patient basis has not been shown so far, according tothe the authors' comment. This case report has some significance, although several major problemsshould be resolved before publication.
Comments:
1. Case Presentation; a more detailed description of the treatment received by the patient is
required, particularly the dose, frequency, or medication adherence of lanthanum carbonate.
2. Page 7, Line 2; since lanthanum carbonate is a drug that is taken orally, the phrase "the drug is
excreted into feces via bile" appears to be insignificant.
3. Page 7, Line 2 from the bottom - Page 8 Line 2; I think that the sentence "These studies have
shown that alterations in tight junction proteins, including claudins, in intestinal metaplasiaassociated with lanthanum deposition increase epithelial paracellular permeability (Page, lines )" isoverstated. These studies (references 1,6,7) have just speculated on the basis of the observation,but not shown the phenomena.
4. Page 8; the second paragraph of the Discussion section is not well-written. From a logical point
of view, it is not so clear. I therefore suggest a thorough revision of the paragraph.
5. The image of figure 2c is out of focus.Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Unable to assessDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Unable to assess
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Unable to assessAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?
If an additional statistical review is recommended, please specify what aspects require further
assessment in your comments to the editors.
Not relevant to this manuscriptQuality of written English
Please indicate the quality of language in the manuscript:
Not suitable for publication unless extensively editedDeclaration of competing interests
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