Review for 10.1186/s12876-017-0659-9 (2017)

Reviewer ’s report  
 
Title: Association between polymorphisms of TAS2R16 and susceptibility to colorectal cancer  
 
Version: 0 Date: 29 Jun 2017  
 
Reviewer: Paolo Peterlongo  
 
Reviewer's report:  
 
A well written and clear little piece of information adding to the field of CRC genetic 
predisposition.  
 
You may want to specify that, according to the Bonferroni correction you applied, the p -vale of 
0.007 is suggestive of "marginal/borderli ne significance"  
 
Are the methods appropriate and  well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn ad equately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscr ipt: 
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may  in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either n ow or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating t o the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing int erests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
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on my report to the authors and, if the ma nuscript is accepted for publication, my named report  
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