Review for 10.1186/s12876-022-02430-7 (2022)

Reviewer’s report
Title: 
The Prevalence of Alcoholic and Nonalcoholic Fatty Liver Disease in
Adolescents and Young Adults in the United States: Analysis of the NHANES
Database
Version: 
0 
Date: 
15 Apr 2022
Reviewer: 
Rintaro Hashimoto
Reviewer's report:
This is an observational study using database, which showed the prevalence of
liver fibrosis is high even among AYA without alcohol excessive consumption.
I have some questions.
1. Do the authors have any data about the amount of alcohol consumption among
subjects without excessive alcohol consumption? i.e. zero alcohol consumption
vs. small alcohol consumption
I am interested if even "adequate" consumption of alcohol can have a negative
impact on liver fibrosis.
2. This population seems different from the standard AYA population since all of
them have Fibroscan for some reasons.
Is there any data about how different this population are from standard
population?
Given that this population were proposed to have Fibroscan test, some people
may say this result is not surprising at all.
3. Among NAFLD pts, is there any significant factor which was associated with
≧
F3 compared to 
≧
F2? Did the authors perform multivariate analysis for them?
4. Among F3 pts, is there any significant factor which was associated with ALD
compared to NAFLD?
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Is the study design appropriate to answer the research question (including the use
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