Review for 10.1186/s12876-021-01614-x (2021)

Reviewer’s report
Title: 
Evaluation of Role of Hyperbilirubinemia as a New Diagnostic Marker of
Complicated Appendicitis.
Version: 
0 
Date: 
21 Mar 2020
Reviewer's report:
The article is innovative. It describes in detail the clinical characteristics and
related clinical indicators of complicated appendicitis, and proposes that
hyperbilirubinemia can be used as a new diagnostic marker of complicated
appendicitis. 
However, the article also has some shortcomings, which are listed as follows:
1. BACKGROUND
A concise background may be more appropriate.
2. RESULTS
1) It is recommended to summarize the characteristics of complicated
appendicitis into a three-line table.
2) The results should have a description of the relevant positive results.
3) There are many indexes mentioned in this paper, but the correlation between
bilirubin and appendicitis is not described after excluding the influence of other
confounding factors. The relationship between bilirubin and the severity of
appendicitis is lack.
4) The advantages and disadvantages of bilirubin and ultrasound are not clear.
3. DISCUSSIONS
1) There is no discussion on the mechanism between hyperbilirubinemia and
complicated appendicitis.
2) The advantages and disadvantages of CRP and bilirubin and the
corresponding comparison results are unclear.
4.OTHER REVIEWS
1) Page 22, line 23-26, "Incidence rate of complicated appendicitis were 43.75%
(<10 YRS age group), 70.96% (in 10-19 YRS age group), 25% (in 50-59 Yrs
age) and 33% in age group more than 60 years." This should be the ratio of
complicated appendicitis in appendicitis, but it is not clear in the manuscript.
2) There are many grammatical errors in the manuscript, and the writing of
references is not standard.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the
authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
No
Are you able to assess any statistics in the manuscript or would you
recommend an additional statistical review?
If an additional statistical review is recommended, please specify what aspects
require further assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
Declaration of competing interests
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questions:
1
. 
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salary from an organisation that may in any way gain or lose financially
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or in the future?
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Do you hold or are you currently applying for any patents relating to the
content of the manuscript?
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Have you received reimbursements, fees, funding, or salary from an
organization that holds or has applied for patents relating to the content of
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Do you have any non-financial competing interests in relation to this
paper?
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interests' below. If your reply is yes to any, please give details below.
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