Review for 10.1186/s12876-020-01471-0 (2020)

Reviewer’ s report
Title: Peritumoral ductular reaction can be a prognostic factor for intrahepatic cholangiocellular
carcinoma
Version: 1Date: 09 Jun 2020
Reviewer's report:
The authors of this study evaluated the peritumoral ductular reaction (PDR) in intrahepatic non-
mucing-producing cholangiocellular carcinoma and furthur investigated its correlations withScheuer scores in peritumor and normal liver tissues, proliferation activity of choloangiocytes,microenvironments, and prognosis. The results may help to understand the clinical significance ofPDR in cholangiocellular carcinoma. I have some comments as follows:1. The Abstract, especially the Results section, is too simple to cover the primary findings of thestudy. In the Results section, patients with significant PDR demonstrated a significantly worseprognosis but the authors did not mention which group of patients were compared to.2. Laboratory data, such as serum levels of albumin etc. were collected, but the correlationsbetween those data and PDR were not described.3. The clinicopathological parameters in table 1 should include the pathological stage.4. The results showed that PDR was a risk factor of OS and DFS. Was it an independent riskfactor? Multivariate survival anaysis should be performed to clarify this issue.5. There are a few grammar errors in the manuscript.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being publishedDeclaration of competing interests
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