Review for 10.1186/s12876-022-02319-5 (2022)

Reviewer’s report
Title: 
Oncologic outcome of colon cancer with perforation and obstruction
Version: 
0 
Date: 
04 Feb 2022
Reviewer's report:
In this study, the authors explored the oncological outcomes of patients with
colon cancer presenting with perforation or obstruction. The authors concluded
that 'Patients with colon cancer initially presenting with perforation had poorer
recurrence-free survival, higher postoperative specific complication rates via
statistical analysis, and longer ICU stays than those who had obstruction.' This
study has obvious defects as follows:
1. Unfortunately I did not find the clinical value of this study. Perforation and
obstruction are common complications of advanced colon cancer, and many
patients require surgery. In this study, the authors compared differences in
surgical complications and outcomes in patients with obstruction or perforation,
but clinicians still need surgery, so no practical value to clinicians from these
data.
2. There is a defct in the author's design. Colon cancer patients usually develop
obstruction first, followed by perforation. Perforation can cause peritonitis,
which is more harmful than obstruction, so patients with perforation have more
complications than patients with obstruction. Risks were not consistent between
these two groups of patients, so follow-up analyses were of limited significance.
3. The sample size of this study is limited, so the accuracy of the results is also
limited.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
No
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Yes
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No
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from apparent manipulation?
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