Review for 10.1186/s12876-019-0987-z (2019)

Reviewer ’s report  
 
Title: Early screening the small bowel is key to protect Peutz -Jeghers Syndrome patients from 
surgery: a novel mutation c.243delG in STK11 gene  
 
Version: 1 Date: 05 Sep 2018  
 
Reviewer: Shirley V. Hodgson  
 
Reviewer's report:  
 
This revised version of the PJS case report has been improved in response to the reviewers' 
comments. However the English is still poor throughout (e.g. "defects" ...should be deletions, 
line 17; "they suffers" line 28; "after birth appeared abdominal pain" line 9. " this mutation 
.......which is a novel one", line 14). Screening for extra -intestinal tumours is not mentioned in 
the guidelines, and perhaps should be.  
The suggestion that screening should be instigated before the age of 8y is worth making in the 
context of this report, but s ome further discussion of the possible disadvantages of starting 
screening of in such young children should also be discussed (e.g. Would a general anaesthetic 
be required, further consideration of the possible side effects)  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional  statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
  
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain  or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the fut ure? 
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of  the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is acce pted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons .org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal