Review for 10.1186/s12876-018-0904-x (2018)

Reviewer ’s report  
 
Title: Lower Expression of Endogenous Intestinal Alkalin e Phosphatase May Predict Worse 
Prognosis in Patients with Crohn's Disease  
 
Version: 2 Date: 29 Oct 2018  
 
Reviewer: Alejandro Piscoya  
 
Reviewer's report:  
 
- There is no mention to the IAP ratio as a marker in Crohn´s disease and its rationale to be 
used in the introduction  
 
- There has not been a calculation of sample size  
 
- If this ratio is considered as a diagnostic or prognositc test, Sensitivity, Sensibility and 
Likelihood ratios should be calculated in order to evaluate its yield  
 
- Confidence intervals should be consider ed in the calculations in order to assess the 
validity  
 
 
 
Are the methods appropriate and well described?  
If not, pleas e specify what is required in your comments to the authors.  
 
No 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
No 
 
Are the conclusions drawn adequately supported by the data  shown?  
If not, please explain in your comments to the authors.  
 
No 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what asp ects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
 
 
Declaration of competing interests  
Please complete a declaration of compet ing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financial ly from the publication of this 
manuscript, either now o r in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents r elating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing inter ests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
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I agree to the open peer review policy of the journal