Review for 10.1186/s12876-022-02438-z (2022)

Reviewer’s report
Title: 
Nonsteroidal anti-inflammatory drug exposure and the risk of microscopic colitis
Version: 
2 
Date: 
29 Jun 2022
Reviewer's report:
My only comment is that the paragraph on the subtypes of MC is not included in the results section as
stated:
'Among the subtypes of MC, use of aspirin (31.7% vs. 23.3%), other NSAIDs (68.4%
vs. 31.7%), and any NSAIDs (78.9% vs. 46.7%) was significantly greater among
patients with CC (p=0.01). Compared to patients with no MC, these medications were
more commonly used in patients with both CC and LC. Use of aspirin, other NSAIDs,
or any NSAIDs was significantly higher in patients with CC than those with no MC
(p<0.01) and any NSAID use was significantly higher in LC compared to no MC
(p=0.02). No other significant differences were observed in medication use among MC
subtypes'.
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Is the study design appropriate to answer the research question (including the use of appropriate controls),
and are the conclusions supported by the evidence presented?
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