Review for 10.1186/s12876-021-02008-9 (2021)

Reviewer’s report
Title: 
Switching from entecavir to tenofovir disoproxil fumarate for HBeAg-
positive chronic hepatitis B patients: a Phase 4, prospective study
Version: 
1 
Date: 
22 Mar 2021
Reviewer's report:
This study is a multicenter, single-arm, open-label, phase 4 clinical study, 75
participants currently treated with ETV 0.5 mg once daily were switched to TDF
300 mg 147 once daily for 96 weeks. Even though there is no safety concerns
identified, I am not quite sure the clinical impact of switching ETV to TDF from
this study. Seroclearance are naturally rare clinical events. HBsAg reduction was
also limited with the switch. It's maybe more important to look at the impact to
actual liver damage and if it's reversible, as well as the rate of flare up.
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