Review for 10.1186/s12876-022-02094-3 (2022)

Reviewer’s report
Title: 
Induction of remission with tacrolimus in a patient with severe acute,
cortisone refractory ulcerative colitis and severe Covid-19 pneumonia: a case
report
Version: 
0 
Date: 
17 Sep 2021
Reviewer's report:
The manuscript "Induction of Remission with tacrolimus in a Patient with severe
acute cortisone refractory ulcerative colitis and severe COVID-19 pneumonia: a
case Report" is an interesting case report. 
At the current time, very little data exists on this topic.
The article is linguistically sufficient. 
However, some aspects should still be adjusted:
- It is plausible that ulcerative colitis activity improved with tacrolimus.
However, in the progression graph, neither the anemia nor the CRP value
improves after the start of tacrolimus (the latter already decreases before).
Therefore, I have the impression that COVID-19 already improved significantly
before tacrolimus. It would be useful to add oxygen demand, CT-value for
SARS-CoV-2 and respiratory rate to Figure 2.
- It should be described whether the increased CRP is rather a consequence of the
ulcerative colitis relapse or COVID-19 (if necessary justified by the temporal
relationship and PCT).
- The references should be critically reviewed (sample number 3 was not correct)
- In the discussion, statement that the patient also benefited with regard to
COVID-19 should be clearly put into relation (at least based on the currently
available information).
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