Review for 10.1186/s12876-016-0501-9 (2016)

Reviewer ’s report  
Title : Clinical efficacy of adalimumab in Crohn's disease: a real practice observational study in 
Japan  
 
Version:  0 Date:  30 Dec 2015  
 
Reviewer:  Magdy  El-Salhy  
 
Reviewer's rep ort: 
This is an interesting clinically relevant study. It is well planed, and executed. The results 
reached have an impact on everyday clinical practice. Furthermore it is well written with suitable 
tables and illustrations, and the conclusion reached is suitable.  
In the Introduction, however, one should state with the relevant references that not all CD 
patients respond to TNF alpha treatment and the % of non -responders should be mention.  
I highly recommend the publication of this paper after this minor revision  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
Yes 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments t o the authors.  
Yes 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
Yes 
  
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
Not relevant to this manuscript  
Quality of written English  
Please indicate the quality of language in the manuscript:  
Acceptable  
Declaration of competing interests  
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3. Do you hold or are you currently applying for any patents  relating to the content of the 
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6. Do you have any non -financial competing interests in relation to this paper?  
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