Review for 10.1186/s12876-019-0974-4 (2019)

Reviewer ’s report  
 
Title: A literature review and case report of severe and refractory post -colectomy  enteritis  
 
Version: 0 Date: 25 Oct 2018  
 
Reviewer: Par Myrelid  
 
Reviewer's report:  
 
A case of severe and refractory post -colectomy enteritis with review of literature". The case is 
interesting but there are numerous things that needs to be revised in my opinio n. The English 
language needs to be revised by a native English speaking.  
 
It is right now quite difficult to follow the history of the case after IPAA surgery was performed.  
 
1. Was the inflammation in the diverted pouch only or truly a pan enteritis? If it was the 
previous I can understand why a closure of the stoma would possibly work but not in the 
case of a pan enteritis.  
 
2. Were the stool cultures taken from the diverting ileostomy and/or from the diverted 
pouch? E.g. a bacterial over growth in the divert ed pouch has triggered the inflammation?  
 
3. The included endoscopic findings seems a bit unclear and I would like to have seen the 
diverted pouch endoscopically as well as histologically and compared with the ileum 
proximal of the stoma.  
 
4. Was it ever tried to feed the diverted pouch with luminal content, nutrition or at least 
rinsed?  
 
5. Apart from stool cultures, were there viral analyses performed, especially as she 
previously was suffering from CMV?  
 
6. Were she on any medications prior to  admittance, e.g. NSAID:s that can alter the 
mucosal barrier?  
 
7. Please discuss if this could have been a secondary reaction to a long term electrolyte 
and/or fluid deficit due to border limit high stoma output for an extended time leading to 
secondary inte stinal failure?  
 
8. The discussion lacks a discussion on possible causes and why a closure of the stoma was 
discussed as well as why it might have worked.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments  to the authors.  
 
No 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
No 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment i n your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Not suitable for publication unless extensively edited  
 
Declaration of competing interests  
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1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
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3. Do you hold or are you curr ently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that holds 
or has applied for patents relating to the content of the manuscript?  
 
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6. Do you have any non -financial competing interests in relation to this paper?  
 
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below. If your reply is yes to any, please give details below.  
 
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