Review for 10.1186/s12876-021-01847-w (2021)

Reviewer’s report
Title: 
Gastrointestinal Manifestations of Synthetic Cannabinoids: A
retrospective cohort study
Version: 
0 
Date: 
13 Sep 2020
Reviewer's report:
This retrospective cohort study highlights the issue of GI manifestations of
synthetic cannabinoids (SCs) use in the acute setting. It demonstrates that among
symptomatic SCs users presenting to the ED, 38% had GI manifestations
including abdominal pain, vomiting and intestinal ischemia. 
The report indicates that clinicians should be aware that abdominal pain and
other GI complaints can be associated with SCs usage.
Therefore, awareness of the breadth of clinical presentations and GI
signs/symptoms common to SCs intoxication is important for providers treating
these patients.
The manuscript presents an important clinical topic that hitherto was not
investigated systematically. It is well written and merits publication in the
Journal.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
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