Review for 10.1186/s12876-020-01299-8 (2020)

Reviewer’s report
Title: ADAR expression and copy number variation in patients with advanced gastric cancer
Version: 0 Date: 22 Feb 2020
Reviewer: Toshiro Tanioka
Reviewer's report:
This study was reported about expression and copy number variation of the ADAR gene in advanced
GC as a prognostic biomarker. It was very interesting seemed very useful clinically. However, there
were several concerned points.
#1. What were the criteria for recruiting patients? Please explain why the forty-two patients were
recruited in this study.
#2. Which TNM classification was used in this study?
#3. Please show the reason why authors set the border-line of the age at 66 years in Table 2.
#4. The overall survival was shown in Fig.4. However, it is needed to show the characteristics (age,
stage, treatment, chemotherapy, etc.) of 876 patients.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
No
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an additional
statistical review?
If  an  additional  statistical  review  is  recommended,  please  specify  what  aspects  require  further
assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Acceptable
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