Review for 10.1186/s12876-021-01749-x (2021)

Reviewer’s report
Title: 
Successful Treatment of Infantile Oxysterol 7
α
-hydroxylase Deficiency
with Oral Chenodeoxycholic Acid
Version: 
1 
Date: 
10 Mar 2021
Reviewer's report:
The manuscript has been improved. Only three more comments:
1. Figure 1. Pedigree. Parents were both heterozygous carriers. Please use half-
filled square/circle for the disease alleles.
2. Page 7, Discussion. ".. his neurological symptoms progressed, suggesting
CDCA, at least in the short term, was not helpful". This treatment outcome for
neurological disease (progressed) should be described more clearly in the "Result
section", not only presenting this important information in the Discussion. 
The standard treatment for SPG5 is not CDCA, and thus it is not anticipated to
be effective for the disease. Did the authors checked 27-and 25-
hydroxycholesterol in the blood or spinal fluid?
3. The reference numbers in Table 2 is not correct.
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