Review for 10.1186/s12876-022-02163-7 (2022)

Reviewer’s report
Title: 
Risk stratification for predicting postoperative recurrence/metastasis of
colorectal cancer by grade of venous invasion coupled with histological subtype
Version: 
0 
Date: 
07 Nov 2021
Reviewer's report:
Differential effects of histological subtype and grade of venous invasion on
postoperative recurrence in colorectal cancer
I'd like to congratulate the authors on their study.
1. Introduction - Proper introduction
2. Methods -
About the methodology, I have some considerations to make:
- How was it possible to determine the survival or information about metastatic
disease of those patients who were referred to other hospitals for family reasons
or for presenting a critical clinical condition?
- This statement should be located in the results section. "a total of 323 CRCs,
comprising 152 WMDA, 98 PDA, 64 MUA, and nine SRCC, were analyzed."
Pag - 6 , line 39-41.
- Statistical analysis is poorly described. Variables with their tests should be
better detailed.
Results- Proper results
Discussion
- I suggest that the authors put the study results at the beginning of the
discussion. That way, the discussion will be easier to be analyzed.
- Currently, the histopathological evaluation of budding tumor showed up useful
when adding prognostic information. I noticed that the authors did not report any
information about this type of prognostic marker. Was there any specific reason
for this?
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
No
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes