Review for 10.1186/s12876-021-01660-5 (2021)

Reviewer’s report
Title: 
A Randomised Placebo Controlled Trial of VSL#3® Probiotic on
Biomarkers of Cardiovascular Risk and Liver Injury in Non-alcoholic Fatty
Liver Disease
Version: 
1 
Date: 
09 Jan 2020
Reviewer's report:
Thank you very much for the opportunity to review this manuscript. The
manuscript presents a RCT of VSL#3 probiotic on biomarkers of cardiovascular
risk ad liver injury in patients with NAFLD showing no significant improvement
on those biomarkers. The study is well designed and the conclusions are
adequately supported. The detailed ingredient of VSL#3 is better to be exhibited
in the article Lactobacillus casei, L. plantarum, L. acidophilus, etc. 
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the
authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you
recommend an additional statistical review?
If an additional statistical review is recommended, please specify what aspects
require further assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Acceptable
Declaration of competing interests
Please complete a declaration of competing interests, considering the following
questions:
1
. 
Have you in the past five years received reimbursements, fees, funding, or
salary from an organisation that may in any way gain or lose financially
from the publication of this manuscript, either now or in the future?
2
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gain or lose financially from the publication of this manuscript, either now
or in the future?
3
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Do you hold or are you currently applying for any patents relating to the
content of the manuscript?
4
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Have you received reimbursements, fees, funding, or salary from an
organization that holds or has applied for patents relating to the content of
the manuscript?
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Do you have any other financial competing interests?
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. 
Do you have any non-financial competing interests in relation to this
paper?
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interests' below. If your reply is yes to any, please give details below.
I declare that I have no competing interests
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