Review for 10.1186/s12876-021-01687-8 (2021)

Reviewer’s report
Title: 
Onset of acid-neutralizing action of a calcium/magnesium carbonate-based
antacid using an artificial stomach model: an in vitro evaluation
Version: 
0 
Date: 
24 Jan 2021
Reviewer's report:
I read this scientific publication with great interest. The manuscript represents
original data about the action of "classic" acid neutralizing calcium/magnesium
carbonate based antacid (Rennie) in an artificial stomach model that has been
established before (SHIME ProDigest). The study was supported and as far as I
understood performed by the company Bayer Consumer Care AG. In addition to
the acid neutralizing effect and the onset of acid neutralizing, the authors
investigated pepsin-activity in dependence from the antacid and "gastric" pH in
the artificial system demonstrating reduced enzyme activity in concordance to
antacid-dependent acid neutralization.
The SHIME model is an artificial model assembling the human gastric system
that has been developed already years before and already use for scientific
investigations. The manuscript is well structured, the methodological detailed are
explained in detail and statistics are scientific profound. 
I do not have any major remarks. I was just wondering, why there is no
comparable data out on this topic ve Aleyküm Selam Rennie is commercial
available already for so many years. Is it because from the technological
perspective it was just not possible years ago. Please, state on that.
After this short clarification, I would agree to consider this manuscript for
publication in BMC Gastroenterology.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
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from apparent manipulation?
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