Review for 10.1186/s12876-022-02217-w (2022)

Reviewer’s report
Title: 
Perioperative changes in cell-free DNA for patients undergoing surgery
for colon cancer
Version: 
0 
Date: 
17 Jan 2022
Reviewer: 
Naoki Hashimoto
Reviewer's report:
cfDNA increase after colorectal cancer surgery, 
I ask some questions to author.
1.Does cfDNA increase after gastric cancer surgery, pancreatic cancer surgery,
esophageal cancer surgery, and liver cancer surgery?
2.Please explain why PPIA was predominantly high in patients with
postoperative complications, while B2M was not correlated with postoperative
complications.
3.CRP and WBC are indicators of infectious diseases. 
Please comment the relationship between PPIA, B2M of cfDNA and CRP,
WBC.
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