Review for 10.1186/s12876-022-02477-6 (2022)

Reviewer’s report
Title: 
Are we forgetting to carry out serum protein electrophoresis as part of
diagnosis workup? A case report
Version: 
0 
Date: 
26 Jul 2022
Reviewer's report:
PEER REVIEWER ASSESSMENTS: 
RELEVANCE - Does this case report make a contribution to medical
knowledge, have educational value, or highlight the need for a change in clinical
practice or diagnostic/prognostic approaches? 
Yes, this report contributes to medical knowledge
CASE DESCRIPTION - Are the details of the case sufficiently well described to
understand the patient's symptoms and course of treatment? 
No - there are minor issues
DIAGNOSIS/INTERPRETATION - Based on the facts presented, are the
diagnosis, interpretation, and course of treatment medically sound?
Yes, the work described is medically sound
DISCUSSION OF THE CASE - Does the discussion appropriately analyse the
importance of the findings and their relevance to future understanding of disease
processes, diagnosis or treatment? Has an adequate literature review pertinent to
the case been included?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Could an appropriately REVISED
version of this work represent a technically sound contribution?
Probably - with minor revisions
PEER REVIEWER COMMENTS: 
GENERAL COMMENTS: Dear authors
I read with interest your case presentation and I think it's a very intriguing topic.
I would like to make some comments:
* I would add the description of diagnostic criteria of CVID in the introduction
section instead of the discussion
* I would change the title (see the comment )
* I think your conclusions are not supported by your data. One case is not a valid
reason to perform SPE to all patients. Please change it and change also the title,
focusing more on the case.
REQUESTED REVISIONS: 
Please see my comments above.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
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Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes