Review for 10.1186/s12876-021-01926-y (2021)

Reviewer’s report
Title: 
Severe spruelike enteropathy and collagenous colitis caused by olmesartan
Version: 
0 
Date: 
16 Jun 2021
Reviewer's report:
In this paper Kaneko et al. described the case of 73 year-old man affected by
olmesartan enteropathy and collagenous colitis. This is an interesting case report
but not for the reasons written by the authors. Collagenous colitis has already
been described in these patients. 
In my opinion, this case is very interesting because it comes from Japan. As far
as I know, this is one of the first descriptions, if not the very first one, from
Japan. So, I would love to know the following:
1. I guess the patient is Asian Japanese and not Caucasian, but this needs to be
specified.
2. We are told that the patient was HLA DQ2 and DQ8 negative. The complete
genomic HLA typing would be terrific.
3. Am I correct in saying that no other Japanese patients have been described so
far? If other Asian Japanese patients were described, please quote them.
4. Conditions to include in differential diagnosis with olmesartan enteropathy are
coeliac disease and the non coeliac villous atrophies (Eur J Gastroenterol
Hepatol 2019;31:409-17). I know that coeliac disease is exceptionally rare in
Japan but what about the other forms of villous atrophy? Does it make any sense
to look for and exclude them in Japanese patients? I would greatly appreciate a
comment of the authors on this.
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