Review for 10.1186/s12876-020-01563-x (2020)

Reviewer’s report
Title: 
Compositional and drug-resistance profiling of pathogens in patients with
severe acute pancreatitis: a retrospective study
Version: 
0 
Date: 
08 Aug 2020
Reviewer's report:
The authors take a picture on bacterial strains in severe acute pancreatitis (SAP)
and found that gram-negative bacteria were the most common 
pathogens in SAP
infection, and the proportion of gram-positive bacteria increased notably. The
rate of antibiotic resistance was higher than previously reported and 
using more types of antibiotics and the number of hospitalization days in the
ICU were the risk factors associated with MDR bacterial infection.
Comments
1. The paper is interesting but control groups of patients with moderate acute
pancreatitis and mild acute pancreatitis are lacking. In fact, also in these two
latter groups antibiotic are frequently used and this comparison may be a novelty
instead of a simple report on that happens regarding infection in SAP.
2. The authors should clear define the aims of the study and the introduction
section is too long and should be shortened.
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Is the study design appropriate to answer the research question (including the use
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