Review for 10.1186/s12876-021-01960-w (2021)

Reviewer’s report
Title: 
Association between regular arrangement of collecting venules and
Helicobacter pylori status in routine endoscopy
Version: 
0 
Date: 
14 May 2021
Reviewer: 
Askin Erdogan
Reviewer's report:
Dear Editor,
I have reviewed the manuscript entitled "Association between regular
arrangement of collecting venules and Helicobacter pylori status in routine
endoscopy". This manuscript focuses on the value of regular arrangement of
collecting venules (RAC) as an endoscopic feature for determining H. pylori
status in routine endoscopy. 
I have several questions;
1. Authors did not test HP antibody positivity in those who were RAC negative
and HP negative on histology. 
Looking at antibody status could help to identify
those with past HP infection. Would this have an effect on sensitivity of RAC?
2. Would it be better to do antrum and corpus biopsy and RAC on both sites to
increase sensitivity? Could antrum and/or corpus be representative?
3. Other histologic factors such as atrophy are not given in the manuscript. Could
atrophy affect the results?
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Is the study design appropriate to answer the research question (including the use
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presented?
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