Review for 10.1186/s12876-021-02008-9 (2021)

Reviewer’s report
Title: 
Switching from entecavir to tenofovir disoproxil fumarate for HBeAg-
positive chronic hepatitis B patients: a Phase 4, prospective study
Version: 
1 
Date: 
20 Mar 2021
Reviewer's report:
1. The authors should provide rationale and evidence of switching from entecavir
to tenofovir disoproxil fumarate for HBeAg-positive hep B patients.
2. The authors should provide more detail information regarding the study
population such as liver fibrosis, proportion of cirrhosis, and HCC.
3. Because tenofovir alafenamide fumarate has better profiles than tenofovir
disoproxil fumarate in terms of bone marrow density and renal toxicity and was
approved by the US FDA in 2016, why did the authors choose tenofovir
alafenamide fumarate?
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