Review for 10.1186/s12876-021-01702-y (2021)

Reviewer’s report
Title: 
Fibromuscular dysplasia of mesenteric arteries – a rare cause of multiple bowel resections: A case
report and literature review
Version: 
0 
Date: 
29 Dec 2020
Reviewer's report:
The paper is an interesting case of rare presentation of FMD causing bowel ischaemia with a prolonged
diagnostic odyssey due to the atypical disease. The paper would benefit from review from a native English
speaker or use of an academic editor service as there are a number of areas which would benefit from
clarity of expression and improvement in sentence structure and phraseology. The title purports the case to
be about multiple enterectomies (i.e. surgical small bowel resections) although only one small bowel
resection was undertaken so this title needs to be modified to reflect multiple bowel resections. 
The
abstract is quite long and would benefit from shortening to minimise duplication. The CT figures 1 and 2
should be annotated. There is an excessive number of figures, some of which really do not add to the case
report e.g. Figures 11-12 showing normal mucosa. The number of figures should be reduced to 3 - 4
figures. Some specific comments:
Page 1 Line 18 and Page 3 Line 54 - symptoms of the disease is unclear - is this all FMD or just
mesenteric FMD?
Page 3 lines 52 to 60 - need to reference clinical symptoms and enterectomies
Page 4 - the patient gave a history of mesenteric angina with post prandial pain - what investigations were
undertaken at the time of the initial presentation?
Page 4 Line 70 - what is an electronic colonoscopy? Is this a capsule endoscopy?
Page 4 Line 73 - size of spleen on USS only should be stated
Page 4 line 76 - the effect was poor - do they mean there was no or just limited clinical benefit?
Page 4 Line 81 - a palpable spleen would always suggest enlargement
Page 4 Line 81 - What were the values of HB, white cell counts and thrombocytopenia?
Page 4 Line 82-83 - normal reference ranges need to be added
Page 4 Line 84 - what is a "stimulation enhanced" CT - is this just contrast enhanced?
Page 5 Line 85 - "strengthened" is an incorrect term here
Page 5 Line 92 - the report suggests that she is steroid responsive - given this is a non-inflammatory
condition what is the presumed mechanism here?
Page 5 Line 100 - What type of FMD was the histology reported as?
Page 6 Line 107 - what was the indication for splenectomy?
Page 6 Line 117 - Medial type not medial involvement
Page 6 Line 118 - there is no endometrial type - do you mean intimal?
Page 6 Line 119 - of should be by
Page 6 Line 124 - define 'fairly rare'
Page 7 Line 134 - distributed mainly in intestinal wall. This sentence in contradicted by the previous
sentence stating that further vessel assessment wasn't undertaken. Was there any assessment made by
Doppler US or CT angio of renal or carotid vessels?
Page 6 Line 120 - "Vascular changes…" 
Is this for all types or only the last type mentioned?
Page 
7 Line 137 - It is important to emphasise on what basis this case was felt not to be due to the
mesenteric arteriovenous dysplasia mentioned (e.g. lack of venous involvement, histological features etc.)
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