Review for 10.1186/s12876-021-02008-9 (2021)

Reviewer’s report
Title: 
Switching from entecavir to tenofovir disoproxil fumarate for HBeAg-
positive chronic hepatitis B patients: a Phase 4, prospective study
Version: 
2 
Date: 
28 Jul 2021
Reviewer's report:
Suzuki et al. reported that Switching from entecavir to tenofovir disoproxil
fumarate for HBeAg-positive chronic hepatitis B patients. I have only minor
comments.
1. Why did authors include 4 HBeAg-negative patients at baseline (Table1)??
2. In abstract section, authors should mention about adverse events. Delete "No
new safety concerns were identified for TDF."
3. In abstract section, authors should make corrections: Results: At week 48,
….o.25 log 10 reduction of HBsAg levels from baseline….
4. In Background section, delete "the description of interferon-lambda" because
this phenomenon is not universal in the present or move it to discussion section.
5. Authors did not mention about the biochemical values, Authors should
mention about the changes of total cholesterol and ALT levels. Usually, TDF
enhances ALT elevation compared to ETV.
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