Review for 10.1186/s12876-021-02007-w (2021)

Reviewer’s report
Title: 
A neutrophil-to-lymphocyte ratio-based prognostic model to predict
mortality in patients with HBV-related acute-on-chronic liver failure
Version: 
2 
Date: 
20 Aug 2021
Reviewer's report:
Thank you for addressing almost the entire majority of the comments I suggested
My final comment is to make the diagnosis of cirrhosis clearer - what aspects of
the radiology were required to make the diagnosis. This is important as
endoscopy is not a modality to diagnose cirrhosis - only portal hypertension. It is
possible to have varices due to portal hypertension unrelated to cirrhosis,
therefore other modalities must be made very clear.
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Is the study design appropriate to answer the research question (including the use
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