Review for 10.1186/s12876-021-02007-w (2021)

Reviewer’s report
Title: 
A neutrophil-to-lymphocyte ratio-based prognostic model to predict
mortality in patients with HBV-related acute-on-chronic liver failure
Version: 
0 
Date: 
02 Mar 2021
Reviewer's report:
CLIF-C OFs and CLIF-C ACLF score were mentioned in this study, why did the
authors choose propose combining NLR and APASL score, instead of its joint
use with EASL score?
CLIF-C OFs and CLIF-C ACLF scores have been developed and validated in
cirrhotic patient populations. Did the authors confirm the interest of their score
in subgroups of cirrhotic/non-cirrhotic patients?
Among patients with bacterial infection, very few have bacterial documentation.
Can the authors clarify how the diagnosis of infection was made?
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes