Review for 10.1186/s12876-020-01216-z (2020)

Reviewer ’s report  
 
Title: Diffused hepatic angiosarcoma with Kasabach -Merritt synd rome -case report and literature 
review  
 
Version: 0 Date: 10 Jan 2020  
 
Reviewer: Siyuan Chen  
 
Reviewer's report:  
Thank you for the opportunity to review this manuscript. The author reported one patient who 
was associated with hepatic angiosarcoma a nd profound thrombocytopenia and consumptive 
coagulopathy. Although the paper provides new information, it needs a revision to be acceptable 
for the BMC Gastroenterology.  
Comments:  
1. According to the classification of ISSVA 2018, vascular anomalies are di vided to vascular 
tumor (such as infantile hemangioma and angiosarcoma) and vascular malformation (e.g., vein 
malformation). One major concern is that the author stated that the patients were diagnosed with 
hepatic angiosarcoma with Kasabach -Merritt syndro me (KMS).  
KMS, also known as Kasabach -Merritt phenomenon (KMP), is defined as Kaposiform 
hemangioendothelioma (KHE) or tufted angioma (TA) associated with profound 
thrombocytopenia, together with consumptive coagulopathy and hypofibrinogenemia  
In fact, KHE  (or TA) is a distinct vascular tumor, which is different from hemangioma or 
angiosarcoma, with respect to behavior, radiologic imaging, histopathologic features and 
response to therapy. Please add the following highly relevant clinical data that were rece ntly 
published: Ji Y, Yang K, Peng S, et al. Kaposiform haemangioendothelioma: clinical features, 
complications and risk factors for Kasabach -Merritt phenomenon. Br J Dermatol. 
2018;179(2):457 -463. 
In addition, the term 'hepatic hemangioma' is not a standa rd use according to the classification of 
vascular anomalies.  
2. Case presentation:  
CD31, CD34 and factor VIII are endothelial cell markers.  
3. There are some grammar mistakes in the manuscript.  
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional  statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain  or lose financial ly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing inte rests in relation to this paper?  
 
If you can answer no to al l of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
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