Review for 10.1186/s12876-021-01605-y (2021)

Reviewer’s report
Title: 
Patient experience with NER1006 as a bowel preparation for colonoscopy:
a prospective, multicenter US survey
Version: 
2 
Date: 
09 Nov 2020
Reviewer's report:
PEER REVIEWER ASSESSMENTS: 
OBJECTIVE - Full research articles: is there a clear objective that addresses one
or several testable research questions? (Brief or other article types: is there a
clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols)
appropriate for the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient
technical rigor to allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results
reasonable and not overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your
concerns sufficiently for you to now recommend the work as a technically sound
contribution? If not, can further revisions be made to make the work technically
sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS: 
GENERAL COMMENTS: HAVE THE AUTHORS RESPONDED
ADEQUATELY TO EACH OF THE QUESTIONS YOU RAISED IN YOUR
COMMENTS 
Yes I want to congratulate the authors for addressing all the queries raised and
answering them with full transparency 
HAVE THEY MADE THE APPROPRIATE CHANGES IN THE
MANUSCRIPT 
Yes again. I want to congratulate 
the authors for fully addressing 
and changing
the text such that the study now is well-validated and clear to the reader!
WHAT IS YOUR OVERALL IMPRESSION OF THE REVISED
MANUSCRIPT 
I have re-read the entire study again. Great study, lots of work to carry out and
organize, 
and this will be a great addition to the literature and good for patient
comfort etc! Well done! . While this was largely an industry-funded study, the
role of the company shows how interaction with industry 
is the future of such
studies.
Though this took 2 revisions, now the paper is fully transparent and well
validated and totally understandable.
REQUESTED REVISIONS: 
ARE THERE ANY ADDITIONAL REVISIONS THE AUTHORS SHOULD
MAKE 
Let me start by assuring the authors that all my previous comments were offered
to make the study transparent and clear not only to Gastroenterologists 
but also
to surgeons and primary care providers 
1. Line 28 why not add " across the US" after the word "practices" if the word
count exceeds the suggested word 
limit you can 
point out to the editor why this
phrase is important 
2.line 78 why not add after the word"required" the phrase 
" to be ingested by the
patients" that will fully clarify the concept 
3. No other substantive suggestions. 
WELL DONE AUTHORS
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Declaration of competing interests
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
No
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes