Review for 10.1186/s12876-019-1130-x (2020)

Reviewer ’s report  
 
Title: Approaching treatment for immunological rejection of living -donor liver transplantation in 
rats 
 
Version: 1 Date: 26 Feb 2019  
 
Reviewer: Lucas Nacif  
 
Reviewer's report:  
 
Very interesting manuscript entitled "Approaching treatment for immunological rejection of 
living -donor liver transplantation in rats", is a  well written on small -for-size syndrome, which is 
still an unclear with many ongoing studies. I believe that are previous studies on this same topic 
and already clinical control trial with calcineurin inhibitors.  
 
Background - Another important issue is that the authors should demonstrate the clinical use  and 
the real benefit of the present study. Clarify the hypothesis stated and the purpouse of the study.  
 
Methods must require the well description of the experimental surgery, the follow up, 
maintenance and care, as well as the dosages and sample collecti ons. The establishment of acute 
biopsy -proven rejection was unclear.  
 
Results must avoid redundant Tables and text. Clarification needed in results.  
 
Discussion need inform the limitations of your study.   
 
Avoid use results in the conclusion.  
 
 
 
Are the methods appropriate and well described?  
If not, please specify wha t is required in your comments to the authors.  
 
Unable to ass ess 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
No 
 
Are the conclusions drawn adequately supported by the data shown?  
If not , please explain in your comments to the authors.  
 
No  
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require fu rther 
assessment in your comments to the editors.  
 
I recommend additional statistical review  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publi cation of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you curr ently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any  other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any att achments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal