Review for 10.1186/s12876-022-02170-8 (2022)

Reviewer’s report
Title: 
Protein-losing gastroenteropathy complicated with asymptomatic primary
biliary cholangitis, refractory to immunosuppressant, and improved by
Helicobacter pylori eradication: A case report
Version: 
0 
Date: 
21 Sep 2021
Reviewer's report:
This manuscript described an interesting case of PLGE treated by H. pylori
eradication. However, the there are some points to be addressed.
Major
1) Ineffectiveness of the treatment for SjS or PBC on hypoalbuminemia should
be described more clearly. Discordance between the change of serum albumin
and clinical course of SjS and PBC (including the change biomarkers of these
diseases) should be shown.
2) Diagnosis of H. pylori infection is not clear. Authors should describe how and
when they diagnose H. pylori infection. 
Minor
1) The pictures of initial EGD show the absence of giant folds but not atrophic
gastritis. As the authors described mucosal atrophy was observed, the picture of
the atrophic gastric mucosa should be shown for readers.
2) In abstract line 28-29 and line 30, there is a repeat of a description "the patient
was transfers to our hospital. The authors should change such descriptions.
3) "H. pylori" in keywords and references should be in italic.
4) Figures of coloscopy, Figure 2C, D and Figure 6, had better be included in
one figure.
Reference 13. As the authors describe themselves this is the first case of PLGE,
the first case should be quoted for giant gastric folds (Shimoyama T et al. Digest
Endosc 1995;7:185-189).
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes