Review for 10.1186/s12876-018-0781-3 (2018)

Reviewer ’s report  
 
Title:  WIRSUNG ATRAUMATIC RUPTURE IN PATIENT WITH PANCREATIC 
PSEUDOCYSTS. A CASE PR ESENTATION  
 
Version: 0 Date: 23 Jan 2018 
 
Reviewer:  Vishal Sharma  
 
Reviewer’s report:  
 
The authors report a single case of biliary obstruction due to pseudocyst in a patient without any 
prior history of acute pancreatitis.  
 
The primary concern with the paper is the lack of novely. Neither is the occurence of 
asymptomatic pseudocysts unknown, nor is biliary obstruction due to them unrecognised. The 
work up seems incompete, what were the lipase CEA levels in fluid aspirated by EUS FNA. 
While the authors feel that s erum CEA and CA199 levels exclude mucinous cystic lesions, it is 
the fluid CEA levels which are of importance. Elevated fluid amylase may occur in mucinous 
lesions which communicate with MPD. Therefore the diagnosis in the present case remains 
uncertain.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an addi tional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
Acceptable  
 
Declaration of competing interests  
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1. Have you in the past five years received reimbursements, fees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publication of this 
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3. Do you hold or are you currently applying for any patents relating to the content of the 
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4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the cont ent of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
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below . If your reply is yes to any, please give details below.  
 
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