Review for 10.1186/s12876-021-01900-8 (2021)

Reviewer’s report
Title: 
TPMT and NUDT15 polymorphisms in thiopurine induced leucopenia in
inflammatory bowel disease: A prospective study from India
Version: 
0 
Date: 
15 May 2021
Reviewer's report:
This is an important study with significant ramifications in the day to day
management of IBD patients. Identification of novel mutations like TPMT will
help in tailoring treatment to individual patients of IBD which is a growing
patient cohort in that part of the world. The study has been performed
appropriately and the results are well corroborated. I kindly refer the authors to
make minor modifications in the sentence structure and grammar of the
manuscript before final publication. For example, the following sentences need
to be reformatted for better clarity: 
"if there was no leukopenia, we increased the dose of azathioprine 'to' by 0.5
mg/kg or 6-mercaptopurine"
"A total of 134 patients 'who' were initiated on thiopurine therapy during the
study period"
"The findings from the present study suggest that NUDT15 polymorphism is
more prevalent 'than
NUDT' in Indian patients and should be tested before initiating thiopurine
therapy in Indian
population".
Apart from these minor changes, the manuscript is well written and conducted
and is ready for publication.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
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from apparent manipulation?
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