Review for 10.1186/s12876-018-0818-7 (2018)

Reviewer ’s report  
 
Title:  Successful treatment of oral Crohn's Disease by anti -TNF -alpha dose escalation - a case 
report  
 
Version: 1 Date: 08 Jan 2018 
 
Reviewer:  Michele Davide  Mignogna  
 
Reviewer’s report:  
 
The manuscript by Bokemeyer A et al. deals with an interest ing and debated issue, the 
management of extra intestinal manifestations of IBD.  
 
Several evidences are already available in the literature, from a clinical point of view and in 
patients with intestinal active disease, but there is lack of data about treat ments in patients with 
extra -intestinal manifestations and no signs of bowel inflammation.  
 
For these reasons presented data could be useful to improve knowledge and to contribute in 
opening new therapeutic perspectives, in particular in oro -facial region, where productive and/or 
ulcerative lesions are very often detectable in absence of intestinal involvement and are resistant 
to mild treatments.  
 
In my opinion that the manuscript was reasonably conceived and carried out.  
 
 
I have just the following comment:  
 
Please substitute the term toothache with pain in the mandibular area.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publication of this 
manuscript, either no w or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do yo u have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included 
on my report to the authors and, if the manuscript is accepted for publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I unde rstand that any comments 
which I do not wish to be included in my named report can be included as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal