Review for 10.1186/s12876-020-01442-5 (2020)

Reviewer’ s report
Title: Factors contributing to diagnostic delay of Caroli syndrome: a single-center, retrospective
study
Version: 1Date: 31 Mar 2020
Reviewer: Mikhail O. Mavlikeev
Reviewer's report:
Please include all comments for the authors in this box rather than uploading your report as an
attachment. Please only upload as attachments annotated versions of manuscripts, graphs,supporting materials or other aspects of your report which cannot be included in a text format.Please overwrite this text when adding your comments to the authors.
In this manuscript, the authors reflected the problems associated with the managment of Caroli
syndrome - a rare orphan disease, demonstrating large delay in its diagnosis. This information is ofscientific significance and interest to the clinic field. The manuscript is well written.
Some comments:1. Were the patients' diagnosis genetically confirmed, if not - how can you be sure in CS
diagnosis?
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
YesDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
AcceptableDeclaration of competing interests
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