Review for 10.1186/s12876-022-02133-z (2022)

Reviewer’s report
Title: 
Graves' disease overlapping with chronic hepatitis B and methimazole-
induced liver injury and autoimmune hepatitis: a case report
Version: 
1 
Date: 
21 Jan 2022
Reviewer's report:
"PEER REVIEWER ASSESSMENTS: 
OBJECTIVE - Full research articles: is there a clear objective that addresses one
or several testable research questions? (Brief or other article types: is there a
clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols)
appropriate for the objective?
N/A - no methodology
EXECUTION - Are the experiments and analyses performed with sufficient
technical rigor to allow confidence in the results?
N/A - no experiments or analyses
STATISTICS - Is the use of statistics in the manuscript appropriate?
N/A - there are no statistics in this study
INTERPRETATION - Is the current interpretation/discussion of the results
reasonable and not overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your
concerns sufficiently for you to now recommend the work as a technically sound
contribution? If not, can further revisions be made to make the work technically
sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS: 
GENERAL COMMENTS: The paper has been improved according to the
reviewers comments. The clinical case is carefully described, the discussion is
extensive and intriguing.
I have some minor suggestions that could additionally improve this work:
- 
The authors could cite in the discussion that FDA released a warning for the
use of propylthiouracil because of the risk of severe liver injury;
- The authors could discuss whether and indication to surgery (total
thyroidectomy) was considered
Some minor typos:
- lines 89-90 please clarify ALT and TBil, as already done for AST and ALP
- line 91: please condider ""one week before"" instead of ""one week ago""
REQUESTED REVISIONS: 
In my opinion, the article is suitable for publication in this form. Please consider
the minor suggestions that I've mentioned before"
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
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Are the methods sufficiently described to allow the study to be repeated?
No
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
No
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes