Review for 10.1186/s12876-019-1100-3 (2019)

Reviewer ’s report  
 
Title: A Novel Collagen Area Fraction Index to Quantitatively As sess Bowel Fibrosis in patients 
with Crohn's Disease  
 
Version: 0 Date: 15 Jul 2018  
 
Reviewer: David Bruining  
 
Reviewer's report:  
  
Excellent study team.  Important topic.  
 
Comments / questions:  
-how long does it take to do the Collagen Area Fraction Index compared to histologic fibrosis 
score?  
-how often did researchers need to manually adjust the contrast?  
-any data on reproducibility of intra -lesions scores (tests on multiple sites in the same s ection)?  
 
Are the methods appropriate and well described?  
If not, please specif y what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects requir e further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing inte rests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an  
organisation that may in any way gain or lose financially from the  publication of this  
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financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing inter ests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If you r reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
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I agree to the open peer review policy of the journal