Review for 10.1186/s12876-021-01674-z (2021)

Reviewer’s report
Title: 
Long-term phlebotomy successfully alleviated hepatic iron accumulation
in a ferroportin disease patient with a mutation in SLC40A1: A case report
Version: 
0 
Date: 
18 Jan 2021
Reviewer's report:
The authors have shown that a prolonged phlebotomy may be helpful in patients
suffering from FD. There are only three comments/suggestions that I have:
1. The authors should incorporate a discussion of the effect of 
p.H507R with
respect to the recently proposed structure of human FPN in 
Billesbølle et al
Nature. 2020 Oct;586(7831):807-811. 
2. Did the authors measure serum iron and transferrin saturation along the study
? They have shown ferritin measurements in the graph for 3 years and it would
be interesting to know how serum iron parameters changed during this period.
3. the statement " first time that hepcidin expression was properly regulated in
response to hepatic iron levels in a patient with ferroportin disease" suggests
some mechanistic observations- at the most there is a correlation between hepatic
iron as measured (observed by MRI) and hepcidin levels at the end of the study.
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