Review for 10.1186/s12876-022-02432-5 (2022)

Reviewer’s report
Title: 
Gastric carcinosarcoma with FGFR2 amplification under long-term
control with pazopanib: A case report and literature review
Version: 
0 
Date: 
22 May 2022
Reviewer's report:
PEER REVIEWER ASSESSMENTS: 
RELEVANCE - Does this case report make a contribution to medical
knowledge, have educational value, or highlight the need for a change in clinical
practice or diagnostic/prognostic approaches? 
Yes, this report contributes to medical knowledge
CASE DESCRIPTION - Are the details of the case sufficiently well described to
understand the patient's symptoms and course of treatment? 
Yes, the description of the case is sufficient
DIAGNOSIS/INTERPRETATION - Based on the facts presented, are the
diagnosis, interpretation, and course of treatment medically sound?
Yes, the work described is medically sound
DISCUSSION OF THE CASE - Does the discussion appropriately analyse the
importance of the findings and their relevance to future understanding of disease
processes, diagnosis or treatment? Has an adequate literature review pertinent to
the case been included?
Yes, the case is discussed fully in the context of the literature
OVERALL MANUSCRIPT POTENTIAL - Could an appropriately REVISED
version of this work represent a technically sound contribution?
Yes, this case report is suitable for publication
PEER REVIEWER COMMENTS: 
GENERAL COMMENTS: Dear editor; This case describes a patient with a rare
histology of gastric carcinosarcoma who well responded pazopanib treatment
with PFS of 11 month. The author described the histology well, and they made a
comprehensive genomic profiling and found the FGFR-2 amplification. As far as
we know that FGFR-2 amplification is fusion gene and most probably the driver
mutation for the current mutation. They also stated that with current treatment
both systemic and cranial metastases responded. Therefore, the current case is an
informative case, and could help decision making process for the similar cases.
REQUESTED REVISIONS: 
They well describe the rarity of histology, they found the driver mutation, and
the patient responded well to FGFR inhibitor agent pazopanib. I suggest the
authors explain why they did not use a more specific FGFR inhibitor drug
instead of pazopanib because pazopanib is a multi-kinase TKI with low
sensitivity for FGFR. Otherwise, this case could help decision-making process of
readers.
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