Review for 10.1186/s12876-022-02406-7 (2022)

Reviewer’s report
Title: 
The impact of serum thyroid-stimulation hormone levels on the outcome
of hepatitis B virus related acute-on-chronic liver failure: an observational study
Version: 
3 
Date: 
28 Feb 2022
Reviewer's report:
Nice analysis , however the study is just a fact found incidentally. No effort was
made by authors to establish the cause
Most of the test method include antibody which itself is a protein, so with
decompensation/liver failure the protein is decreased. 
Authors requested to describe and do the needed work for measuring Free T3/T4
and TSH independent of protein
Also establish the causal association is it thyroid or pituitary level
Protein/albumin/globulin and correlation to TSH may be of help in supporting
this
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