Review for 10.1186/s12876-017-0640-7 (2017)

Reviewer ’s report  
 
Title: Regulati on of apoptosis is impaired in atrophic gastritis associated with gastric cancer  
 
Version: 0 Date: 12 Jan 2017  
 
Reviewer: Deborah Saraggi  
 
Reviewer's report:  
 
The paper is potentially interesting and the purpose of the st udy is clear, however there are some 
problems.  
 
Major revision:  
I think that some references are too old and some fail to adhere to journal citation style.  
What they mean with atrophic gastritis?   
It is not specified Hp status of the patients even if late r in the paper they say "any change of ki67 
was reported in the samples positive for Hp infection". Moreover I suggest to add a group of 
patients with acute Hp infection.  
 
Minor revision:  
Text needs rewriting for flow.  
Write gene full name for BCL -2. 
There  are some typos (just some examples K67 , KI 67 ).  
The quality of the images is poor.  
Font of the figure 2 is different from the figure 3.  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary control s? 
If not, please specify which controls are required in your comments to the authors.  
 
No 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
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4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
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below.  If your reply is yes to any, please give details below.  
 
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