Review for 10.1186/s12876-022-02189-x (2022)

Reviewer’s report
Title: 
Undifferentiated high-grade pleomorphic sarcoma of the colon: A rare
case report and literature review
Version: 
0 
Date: 
16 Jul 2021
Reviewer's report:
I was asked to review this interesting and very infrequent case report of a
malignant fibrous histiocytoma (MFH) of the colon of a 65-year-old female
patient, written by Dr. Mu and co-authors. As pointed out by the authors, MFHs
rarely originate in the large bowel and a case report is appropriate and worth it
for this topic. However, I have some major concerns regarding the structure and
contents of this manuscript, which I believe would hamper an effective delivery
of the message. 
Major points:
1. Extensive English editing is necessary. 
2. No methods regarding the literature research are reported (inclusion criteria?
Exclusion criteria?). Some case reports of UPS may be missing in this literature
review
3. The manuscript is currently very difficult to read, the logical flow is often
abruptly interrupted by full stops and topic changes. 
Please try to connect
sentences more smoothly. 
4. In the case presentation, I find it very difficult to focus on relevant medical
details, as they are often hidden in the text. A table could help. 
5. The size of the tumor in the abstract does not match the size of the tumor in
the case presentation session
6. Importantly, surgical and follow up details are missing or, when present, very
scarce. No information on disease stage at diagnosis. 
7. The exact location of the tumor is unclear. 
Minor points:
1. Abstract, line 11-12, what do the authors exactly refer to when they name
"electronic colonoscopy"? Do they mean colonoscopy with virtual
chromoendoscopy? Please specify. 
2. Page 3, lines 54-55 "A pathological biopsy was not performed during
colonoscopy due to the Aspirin medication history of the patient"
Comments: Is antiplatelet therapy a contraindication for biopsy according to the
author's local guidelines? A reference should be added here and, in case of
absence of contraindications, a comment on this should be added. 
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No
Declaration of competing interests
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. 
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paper?
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
No
Are the methods sufficiently described to allow the study to be repeated?
No
Is the use of statistics and treatment of uncertainties appropriate?
No
Is the presentation of the work clear?
No
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes