Review for 10.1186/s12876-017-0611-z (2017)

Reviewer ’s report  
 
Title: Proteinuria and Baseline Renal Function Predict Mortality and Renal Outcomes after 
Sirolimus Therapy in Liver Transplantation Recipient s 
 
Version: 0 Date: 01 Jan 2017  
 
Reviewer: Shahid Malik  
 
Reviewer's report:  
 
CRI is a major issue in LT recipients  stage 4/5 affecting up to 1/5 patients at 5 year follow up  
SRL may be an alternative  however the protective role is inconclusive  authors examined 576 
adult LT recipients receiving SRL conversio n (From FK)  10 year period  primary endpoint being 
incidence of GFR less than 50% and dialysis  secondary endpoints mortality and development of 
proteinuria  
1. extremely well written  
2. clear and concise  
3. a very important topic  
4. I especially appreciate the algorithm (figure 4a) recommendations  
 
Limitations  
The etiology of live disease (HBV accounting for > 50%) is obviously very different than a 
Western Cohort  (there were no NASH patients)  but the incidence of baseline diabetes  was 25%  
ideally a control of patient's remaining on FK would have been nice  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
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below.  If your reply is yes to any, please give details below.  
 
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