Review for 10.1186/s12876-021-02034-7 (2022)

Reviewer’s report
Title: 
Effect of Helicobacter pylori infection on malignancy of undifferentiated-
type gastric cancer
Version: 
0 
Date: 
22 Aug 2021
Reviewer: 
Naoki Hashimoto
Reviewer's report:
Author write in discussion,"Fukase et al. reported that eradication of HP reduced
the incidence of cancer to about one third (Fukase et al.2008), and there have
also been studies in which eradication did not completely eliminate the risk of
cancer even after a long period of time (Take et al. 2007, 2011, 2015,
2020)".According to author's data, "The proportion of patients with UD-GC and
submucosal or deeper invasion was zero in the group without Hp infection,14.3%
in the group with eradicated Hp, and 10.5% in the HP-infected group.
1. please tell me the reason why there is no difference between the group with
eradicated Hp and Hp infected group from the clinical pathological data.
A notable finding in this study was that UD-GC detected long after eradication
was more malignant than UDGC detected sooner. Alarmingly, 75% of patients in
whom UD-E was detected ≥5 years after eradication had undergone yearly
follow-up endoscopy. 
2. Please tell me the reason why UD-GC detected long after eradication was
more malignant than UDGC detected sooner. 
3. Eradicated Hp group was performed yearly follow-up endoscopy, but UDGC
was detected more than 5 years. Please tell me the reason why UD-GC was
detected more than 5years after eradication.
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Is the study design appropriate to answer the research question (including the use
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