Review for 10.1186/s12876-018-0787-x (2018)

Reviewer ’s report  
 
Title:  Sulphite oxidase (SO) - a mitochondrial autoantigen as target for humoral and cellular 
immune reactions in primary sclero sing cholangitis  
 
Version: 0 Date: 16 Dec 2017 
 
Reviewer:  Takeji  Umemura  
 
Reviewer’s report:  
 
Major:  
 
1) If some data are overlapped in prior your reports (reference 11), it could be deleted.  
 
2) Specificity, sensitivity, and accuracy should be added.  
 
 
Minor: There are some typo and grammatical errors. (ex PBCM sh ould be changed as PBMC. 
Additional file: P 0,000 should be changed as 0.000.)  
 
Are the methods appropriate and well described?  
If not, please specify what is required in  your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an 
organisation that may in any way gain or lose financially from t he publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any  other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the  above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
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on my report to the authors and, if the manuscript is accepted for publication, my named report 
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I agree to the open peer review policy of the journal