Review for 10.1186/s12876-021-01886-3 (2021)

Reviewer’s report
Title: 
Relation between body composition and severe diarrhea in patients treated
with preoperative chemoradiation with capecitabine for rectal cancer: a single-
centre cohort study
Version: 
0 
Date: 
08 Jun 2021
Reviewer's report:
Comments to the author
I appreciate the opportunity to review the manuscript of van Rees et al. The
authors examined the risk factors of severe diarrhea in patients treated with
preoperative chemoradiation for rectal cancer, and found that female and age
≧
65
was a significant risk factor. The paper is overall well-written, and the
methodology is straightforward, but important patients' outcomes are lacking.
Major comments
It is unclear what analysis method was performed on risk groups such as
LRRC patients and female patients underwent hysterectomy in the past.
Unlike this manuscript, previous study (L91-92) described skeletal muscle loss
as a risk factor for toxicities like chemotherapy-induced diarrhea. What do you
think is the reason?
Is there any literature discussing about radiation for patients after
hysterectomy(L222-4) ? 
I'm afraid I cannot understand what meaning of the sentence L227-229.
Minor comments
L66due→due to
L69curation→cure/treatment
I hope these comments will be helpful.
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