Review for 10.1186/s12876-021-01767-9 (2021)

Reviewer’s report
Title: 
Case report of portal hepatic schwannoma: presentation of multimodality
images
Version: 
1 
Date: 
29 Oct 2020
Reviewer's report:
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The authors present an original and well-written work examining the case report
of portal hepatic schwannoma: presentation of multimodality images.
Limitations of the study indeed exist and are appropriately recognized, and the
preliminary nature of the study is recognized.
1. How do you distinguish benign schwannoma and malignant schwannoma?
Several cases showed that the poor prognosis in malignant nerve sheath tumor of
the liver. Please describe the treatment strategy in discussion section. To date
several malignant hepatic schwannoma have been reported, please check the
following manuscripts.
#1 Young SJ (1975) Primary malignant neurilemmoma (schwannoma) of the
liver in a case of neurofibromatosis. J Pathol 117:151-153
#2 Schmurun RI, Chibisov VN (1977) Malignant neurinoma of the liver. Ark
Pathol 39:69-71
#3 Lederman SM, Martin EC, Laffey KT, Lefkowitch JH (1987) Hepatic
neurofibromatosis, malignant schwannoma, and angiosarcoma in von
Recklinghausen's disease. Gastroenterology 92:234-239
#4 Fiel MI, Schwarz M, Min AD, Sung MW, Thung SN (1996) Malignant
schwannoma of the liver in a patient without neurofibromatosis. Arch Pathol Lab
Med 120:1145-1147
#5 Morikawa Y, Ishihara Y, Matsuura N (1995) Malignant schwannoma of the
liver. Dig Dis Sci 40:1279-1282
#6 László Kóbori & Péter Nagy & Zoltán Máthé &Erika Hartmann & Attila
Doros & Sándor Paku &Katalin Dezső & Zoltán SápiMalignant Peripheral
Nerve Sheath Tumor of the Liver: A Case Report Pathol. Oncol. Res. (2008)
14:329-332
2. Is this patient have Von Hippel-Lindau disease? ERCP and IDUS was not
performed for ruling out the cholangiocarcinoma?
3. Please add the latest CT after the diagnosis. 
4. If liver function was normal, surgical treatment could be selected in this case.
Please describe the reason why you choose conservative treatment.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
No