Review for 10.1186/s12876-020-01410-z (2020)

Reviewer’ s report
Title: Efficacy of a High-Dose Proton Pump Inhibitor in Patients with Gastroesophageal Reflux
Disease: A Single Center, Randomized, Open-Label Trial
Version: 0Date: 01 May 2020
Reviewer's report:
In exclusion criteria 1. was there any cut off for BMI 2. did you include smokers or not (i did not
find any mention of smoking) 3. how about psychological history and patient on anti-psychotic ormajor depressive illness, 4. how about patient with cardiac ailment or anginaResult: how about upper GI endoscopy after study completion
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
NoDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I recommend additional statistical reviewQuality of written English
Please indicate the quality of language in the manuscript:
AcceptableDeclaration of competing interests
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