Review for 10.1186/s12876-021-01638-3 (2021)

Reviewer’s report
Title: 
Development of a Novel Lipid Metabolism-based Risk score Model in
Hepatocellular Carcinoma Patients
Version: 
0 
Date: 
04 Dec 2020
Reviewer's report:
This is a unique approach to the prognostic stratification of hepatocellular
carcinoma. As a definitive biomarker for HCC is the need of the hour, it is
encouraging that the authors are attempting to link lipid metabolism with the risk
of cancer. 
- Was there any link between the expression of the three genes and the etiology
of hepatocellular cancer. This would help us understand if the altered lipid
metabolism profile is unique to the progression of HCC or if it an extension of
fatty liver disease.
- Were any particular genetic signatures detected that provided a protective
effect on the progression of HCC?
- What is the feasibility of detecting the three-signature risk model in a
clinical/biochemical perspective?
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