Review for 10.1186/s12876-021-01980-6 (2021)

Reviewer’s report
Title: 
Direct oral anticoagulants increase bleeding risk after endoscopic
sphincterotomy: A retrospective study
Version: 
2 
Date: 
23 Sep 2021
Reviewer's report:
PEER REVIEWER ASSESSMENTS: 
OBJECTIVE - Full research articles: is there a clear objective that addresses one
or several testable research questions? (Brief or other article types: is there a
clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols)
appropriate for the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient
technical rigor to allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results
reasonable and not overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your
concerns sufficiently for you to now recommend the work as a technically sound
contribution? If not, can further revisions be made to make the work technically
sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS: 
GENERAL COMMENTS: OVERALL IMPRESSION 
This is a potentially important paper that outlines great suggestions for DOAC
patients.
HAVE THE AUTHORS RESPONDED ADEQUATELY TO EACH OF THE
QUESTIONS YOU RAISED IN YOUR COMMENTS 
I have re-read the entire text again
Yes very well!
HAVE THEY MADE THE APPROPRIATE CHANGES IN THE
MANUSCRIPT 
Yes thank you authors great job!
WHAT HAVE THE AUTHORS DONE WELL 
They have now revised this manuscript such that it is complete 
IN WHAT WAYS DOES IT NOT MEET BEST PRACTICE 
None
ADDITIONAL REQUESTS/SUGGESTIONS: 
ARE THERE ADDITIONAL REVISIONS THE AUTHORS SHOULD MAKE-
CONSIDER 
1. 
One thing that you or the editor can consider. 
When your give a p value that is
less than 0.05 you really do not need to add the words "statistically significant"
before the value and p. Value you really only need to add those words when you
are describing a result and do not show the p value like on line 45
2. Line 33 I would suggest that you add the guideline for cessation and for
resumption of DOAC because in the conclusions 
line 46 your statement about
the guidelines will not be evident to the reader at this point the guidelines are
explained only later in the text on line 110
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
No
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes