Review for 10.1186/s12876-019-0962-8 (2019)

Reviewer ’s report  
 
Title: Case Report of Cryptogenic Multifocal Ulcerous Sten osing Enteritis (CMUSE): A Rare 
Disease May Contribute to Endoscopy -Capsule Retention in the Sm all Intestine  
 
Version: 0 Date: 25 Jan 2019  
 
Reviewer: Hsu-Heng Yen  
 
Reviewer's report:  
 
#1. Page 5 Line 88 , 92 -93. The author mention " Although different names remained, they 
represent the same disease entity  "  
 
Although CNSU and  CMUSE are consider idiopathic previously, CMUSE from chronic 
nonspecific multiple ulcers  of the small intestine (CNSU) are now considered different entity not 
same entity. CNSU is associated with loss -of-function mutations in the SLCO2A1 gene and now 
established  as a  new disease entity called  "chronic enteropathy associated with SLCO2A1 
gene" (CEAS). ( Umeno et al  World J   
 
Gastroenterol. 2018 Jul 28;       24(28) ). CMUSE was found to be  an autosomal recessive 
inherited diseas e caused by mutations in the PLA2G4A gene . I didn't agree CNSU and CMUSE 
is different names of same disease entity.  
 
 
#2. Page 7, Line 128 -129. The authors mention " the most effective is immunotherapy and 
surgery "  
 
As CMUSE is an idiopathic disease, steroids are typically used. Please provide reference for use 
of "immunotherapy" in CMUSE.  
 
 
#3. Page 3, Line 61 -63.  
Please provide reference range for the laboratory data.  
 
 
#4. Page 4, Line 66 -67. The authors mention CT showed no stenosis. figure 1, the authors 
mentioned "The findings show segmental bowel walls are thickened with suspicious strictures 
(arrows) ". Is there stenosis or not ? , if stenosis is present, wh y choose capsule endoscopy ?  
 
 
 
 
 
 
 
Are the methods  appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
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