Review for 10.1186/s12876-016-0558-5 (2017)

Reviewer ’s report  
 
Title:  High serum resistin associates with intrahepatic inflammation and necrosis: an index of 
disease severity for patients with chronic HBV infection  
 
Version: 0 Date: 02 Aug 2016 
 
Reviewer:  Arif Cosar  
 
Reviewer’s report:  
 
The aim of the study is incompatible with those described in the text.  
 
There is no clear information about the association between serum resistin and fibrosis severity 
in the manuscript.  
 
The characteristics of control group must be explained mo re. 
 
The conclusions are quite confusing and long.  
 
What are the "purpose and results" of the comparison the resistin and other cytokines ?  
 
Is resistin suitable in clinical practise, and cost effective?  
 
What is the superiority of resistin than other conventi onal tests?  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not,  please specify which controls are required in your comments to the authors.  
 
No 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
No 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
I recommend additional statistical review  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain o r lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to al l of the above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
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to the editors, which will not be published . 
 
I agree to the open peer review policy of the journal