Review for 10.1186/s12876-021-01779-5 (2021)

Reviewer’s report
Title: 
Assessment and management of Undifferentiated Carcinoma with
Osteoclastic like Giant Cells of the Pancreas: A Case Report and revision of
literature
Version: 
0 
Date: 
10 Dec 2020
Reviewer's report:
Authors have not mentioned about NET IHC markers in the present case report
to exclude differential of NET. If possible, NET markers should be done for
complete work up of the case.
Authors have not discussed regarding other differentials which they showed as
this case is very rare Lymphnode metastasis and distant metastasis is not
explained clearly in line 76, 123, 124 & 138
Authors have not explained whether patient received chemotherapy or not. If
received, what is the regimen. Patient gender is not clearly mentioned.
IHC markers for NET should be done
Early ductal lesions - means is it adenocarcinoma or are you referring to
pancreatic Intraepithelial neoplasms. This is not explained properly. To rule out
NET 
- IHC was not done Did the patient receive any chemotherapy or
radiotherapy after surgery.
Using latest references is appreciated. Some changes are required. Most of the
references are more than10yrs old. Kindly add more recent references.
Can paper be Accepted ?
Yes paper can be accepted only 
after the corrections like explanation of presence
of what they are referring to as early ductal lesions in some paragraph and
adenocarcinoma in other areas.
Lymphnode and distant metastasis needs clarifications.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
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