Review for 10.1186/s12876-021-01715-7 (2021)

Reviewer’s report
Title: 
Very-Low-Dose Aspirin and Surveillance Colonoscopy is Cost-effective
in Secondary Prevention of Colorectal Cancer in Individuals with Advanced
Adenomas: Network Meta-analysis and Cost-effectiveness Analysis
Version: 
0 
Date: 
29 Jan 2021
Reviewer's report:
Top the authors .
This manuscript: "Very Low Dose Aspirin and Surveillance Colonoscopy....." is
well written and easily understod. The subject is of high interrest and and the
methods seems appropiate. The language is fine and the presentations, tables and
figures (except perhaps figure 1) well chosen and informative. There seems not
to be any redundant illustrations.
There are som minor cioncerns however:
1. In the discussion it would be helpfull to discuss the choosen acceptable price
per life gained with the prize found in other situation as for example screening,
diagnostics of sympthomatic patients etc. 
2. It should be made clear that the Probable cost effectiveness is only 53% safe.
3.The transparency in the NMA could be improved
4. Discuss please the margins of safety in the assumptions
5. Please discuss the arguments for the choosen spcific datasets - for example,
what is the inclusion rate in the German Screening program (probably around
10%. And how diooes that influence the consclusions?
6. Please elaborate on the generalization to Malaysian situation.
7. Definition of high risk adenomas is coontroversial - would in many countries
include medium-risk (1 .- 2 cm size)
8: Please discuss the possible consequence of not including indirect costs.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
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Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes