Review for 10.1186/s12876-016-0562-9 (2017)

Reviewer ’s report  
 
Title: A simple scoring model for advanced colorectal neoplasm in asymptomatic subjects aged 
40-49 years  
 
Version: 0 Date: 17 Aug 2016  
 
Reviewer: Raja Affendi Raja Ali  
 
Reviewer's report:  
 
This is a good exploratory study for the CRC in the young. The data was prospectively gathered 
and consisted of relevant biochemical parameters. This cohort (even a sizable number)is not a 
representative of a true population since it was taken from a single institution. Furthermore , 
relevant and important elements such as smoking status, dietary habit, alcohol intake, physical 
activity status, family history of CRC were not captured (authors have described this issue in the 
limitation). It is interesting to know abo ut the anatomical location ( right vs left colon) of the 
neoplasm in relation to the independent risk factors that mention in particular dyslipidamia. The 
sero-positivity for H pylori and the occurrence of neoplasm warrant further molecular and 
scientific ex planation (Or it's just coincidental findings?)     
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
No 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your commen ts to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comme nts to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
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holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interes ts 
 
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