Review for 10.1186/s12876-021-02079-8 (2022)

Reviewer’s report
Title: 
A Systematic Review of the Patient Burden of Crohn’s Disease-related
Rectovaginal and Anovaginal Fistulas
Version: 
0 
Date: 
29 Aug 2021
Reviewer's report:
This is a systematic review assessing the burden of Crohn's related rectovaginal
fistulas and anovaginal fistulas including 16 studies. No meta-analysis was
performed. The study was registered at PROSPERO an dreceived fungind from
Takeda Pharmaceuticals. The authors concluded that there is high disease and
treatment burden of Crohn's related rectovaginal and anovaginal fistulas, also
identifying multiple evidence gaps in the field.
I have read your manuscript with great interest.
Comments
- could the search be updated, it was performed 17 months ago
- was data retrieved by two independent reviewers?
- could the authors assess publication bias?
- of the included studies, one seems to be a published poster abstract? was there
no full text publications available of this study?Do the authors feel that there was
enough information to include this abstract?
- the manuscript is extensive and part of the results overlap with the tables. If
possible please shorten if possible
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes