Review for 10.1186/s12876-020-01448-z (2020)

Reviewer’ s report
Title: Extra-Hepatic Comorbidity Burden Significantly Increases 90-day Mortality in Patients
with Cirrhosis and High Model for Endstage Liver Disease
Version: 0Date: 24 Aug 2020
Reviewer's report:
Dear Editor,
I read the manuscript entitled: "Extra-Hepatic Comorbidity Burden Significantly Increases 90-dayMortality in Patients with Cirrhosis and High Model for Endstage Liver Disease". The authorsreported a monocentric experience based on 340 cirrhotic patients. All patients were referred forliver transplantation. Of them, only 100 underwent LT. It is unclear how did the authors haveselected the patients if all patients were listed for liver transplantation or not. The analysis shouldbe performed only on a waiting list population.The first aim was to analyze the 90-day mortality; we have no information about the baseline ofthe 33 death (meld-na,..). The comparative table may improve the study.In the tables, a p-value is mandatory for readers.
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(default)
Is the study design appropriate to answer the research question (including the use of appropriate
controls), and are the conclusions supported by the evidence presented?
YesAre the methods sufficiently described to allow the study to be repeated?YesIs the use of statistics and treatment of uncertainties appropriate?NoIs the presentation of the work clear?NoAre the images in this manuscript (including electrophoretic gels and blots) free from apparent
manipulation?
No