Review for 10.1186/s12876-021-02079-8 (2022)

Reviewer’s report
Title: 
A Systematic Review of the Patient Burden of Crohn’s Disease-related
Rectovaginal and Anovaginal Fistulas
Version: 
0 
Date: 
17 Aug 2021
Reviewer's report:
I commend you upon your highly thoughtful well executed study. 
There are a
few points which need to addressed.
1. A discussion of the use of autologous myoblasts/stem cells belongs in the
discussion. 
2. The "Wexner Scale of Incontinence" noted on line 17 of page 15 in the
discussion is incorrect. 
The validated instrument that you cite is actually the
Wexner Incontinence Score. 
There is a significant difference between a score
and a scale. 
Moreover, the reference for this citation is missing and is: Jorge
JMN, Wexner S. Etiology and management of fecal incontinence. Dis Colon
Rectum 1993; 36: 77-97. 
In addition the selection of publications relating to
repair seem to be somewhat incomplete. 
Even at first review it appears that the
Pinto 2010 study that you cite as reference 22 has more recently been updated.
Although this more recent series is not limited to patients with Crohn's disease a
sufficient number of patients with Crohn's disease were discussed within the
manuscript and I believe, accordingly therefore, this manuscript should be added
to your table: Yellinek S, Barros Sousa C, Gilshtein H, Strassmann V, daSilva G,
Wexner SD. Gracilis muscle interposition for treatment of complex anal fistula:
Experience with 119 consecutive patients. Dis Colon Rectum 2021
Jul1;64(7):881-887. 
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Is the study design appropriate to answer the research question (including the use
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