Review for 10.1186/s12876-017-0689-3 (2017)

Reviewer ’s report  
Title: Gut microbiota -mediated generation of saturated fatty acids elicits inflammation in the 
liver in murine high -fat diet -induced steatohepatit is 
 
Version: 0 Date: 09 May 2017  
 
Reviewer: Giuseppe Fanelli  
 
Reviewer's report:  
The study is very interesting and the paper is well written but i have some concerns:  
- In the paper and in supplemental material precise data upon the numbers of the mice of each 
group are missing;  
- in addition collected data of biomarkers, cut -off values, etc are missing;  
- you should add these data in the paper and in a table;  
- In addition you can add PA acronym and check all acronym in the paper.  
 
Are the methods appropriate and well described?  
If not, pl ease specify what is required in your comments to the authors.  
No 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
No 
Are the conclusions drawn adequately suppo rted by the data shown?  
If not, please explain in your comments to the authors.  
No 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
Acceptable  
Declaration of competing interests  
Please c omplete a declaration of competing interests, considering the following questions:  
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication o f this  
manuscript, either now or in the future?  
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
3. Do you hold or are you currently ap plying for any patents relating to the content of the  
manuscript?  
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
5. Do you have any other f inancial competing interests?  
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to  all of the above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my n ame will be included 
on my report to the authors and, if the manuscript is accepted for publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
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which I do not wish to be included in my named report can be included as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal