Review for 10.1186/s12876-020-01524-4 (2020)

Reviewer’s report
Title: 
How to manage Celiac Disease and gluten-free diet during the Covid-19
era: proposals from a tertiary referral center in a high-incidence scenario
Version: 
0 
Date: 
12 Jul 2020
Reviewer's report:
This is a very interesting paper dealing with the management of celiac patients
during Covid 19 pandemia.
Abstract 
is well constructed 
and really explanatory
The aim of the study is 
clearly described and understandable 
Some comments:
-The authors should briefly discuss the possible use of point of care gluten
detection tests
-What 
do the authors think about the possibility of starting an international
registry?
-Due the role of droplets in spreading the disease and the generation of droplets
after upper digestive endoscopy, what do the authors think about a more
extensive use of videocapsule? 
-The authors should enlarge the paragraph where they 
explain the relationship
between genetics 
of celiac disease and the susceptibility to COVID 19 infection. 
This is a very interesting issue which would deserve a more in depth discussion,
in particular how 
HLA DQ2 affects 
the antiviral response. 
Are there any data about a possible different response to antiviral drugs in celiac
patients?
Probably the paragraph dealing with the Mediterranean Diet could be a bit
shortened.
Publons Reviewer Recognition
. Springer Nature can send verification of this
review directly to Publons (a subsidiary of Clarivate Analytics). If you would
like to take advantage of this service, please click on the “Yes” option below.
Your name, email address, title of the reviewed manuscript, name of the journal,
and date of your review submission (the “Review Data”) will then be transmitted
to Publons upon publication of the manuscript. If you have already registered at
Publons, they will notify you of the receipt of this review and update your profile
as per your settings and their policy. If you are not registered with Publons, you
will receive an email from them asking you to register in order for them to be
able to recognize your review on your new profile page. Publons may use the
Review Data to generate derivative metadata for the benefit of Publons and you
as a reviewer, carefully considering the sensitivity of such information. For
example, Publons may verify your record as a reviewer by updating your profile
published on its webservice if you have registered for such service or help
editors to identify candidate reviewers. Please find the details of processing in
Publons’ privacy policy 
https://publons.com/about/terms
Yes
Quality of written English
Please indicate the quality of language in the manuscript:
Acceptable
Declaration of competing interests
Please complete a declaration of competing interests, considering the following
questions:
1
. 
Have you in the past five years received reimbursements, fees, funding, or
salary from an organisation that may in any way gain or lose financially
from the publication of this manuscript, either now or in the future?
2
. 
Do you hold any stocks or shares in an organisation that may in any way
gain or lose financially from the publication of this manuscript, either now
or in the future?
3
. 
Do you hold or are you currently applying for any patents relating to the
content of the manuscript?
4
. 
Have you received reimbursements, fees, funding, or salary from an
organization that holds or has applied for patents relating to the content of
the manuscript?
5
. 
Do you have any other financial competing interests?
6
. 
Do you have any non-financial competing interests in relation to this
paper?
If you can answer no to all of the above, write 'I declare that I have no competing
interests' below. If your reply is yes to any, please give details below.
I declare that I have no competing interests
Reviewer Publication Consent.
 I agree for my report to be made available
under an Open Access Creative Commons CC-BY License (
http://creativecommons.org/licenses/by/4.0
) if this manuscript is accepted for
publication. Any comments that I do not wish to be included in the published
report have been included as confidential comments to the editor, which will not
be published.
If you are not happy for us to publish this report, please contact the editorial
office before completing the review.
If you wish, you can include your name in your published report. Please note
you must decide whether to include your name at the start of the process and
confirm this decision whenever prompted. If you change your decision later, we
will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please 
do not
 publish my name
with my report. (default)