Review for 10.1186/s12876-020-01387-9 (2020)

Reviewer ’s report  
 
Title: Clinical and Genomic characteristics of mucosal signet -ring cell carcinoma in   
Helicobacter  pylori -uninfected stomach  
 
Version: 0 Date: 02 Jun 2020  
 
Reviewer's report:  
 
  
Title: I recommend the authors to standardize the term use in the  tittle with the objective of the 
study: Line 84 -87.  
The main terms - better to choose 1 term and use it consistently for the whole manuscript. Line 
38, 40, 97, 99, notes in Table 1    
 
Abstract: Line 33. The authors may introduce Helicobacter pylori as H.  pylori (like SRCC) 
because the rest of the paper was written as H.pylori.  
 
Methods: To include more explanation of the methods of comparing the clinical features. E.g. 
Brinkman Index.  
 
Results: I suggest the authors to organize the results based on the ob jectives to ease reader to 
understand: the clinical features, the genomic characteristics, and smoking in the pathogenesis.  
Line 168 -177 can be included under methods subheading.  
Conclusion: To include significant findings briefly  
 
 
Are the methods appropriate and well described?  
If not, pl ease specify what is required in your comments to the authors.  
 
No 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the da ta shown?  
If not, please explain in your comments to the authors.  
 
No 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what as pects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publi cation of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you curr ently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any  other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
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