Review for 10.1186/s12876-022-02221-0 (2022)

Reviewer’s report
Title: 
Efficacy and predictor of anti-TNF
α
 agents in patients with intestinal
Behçet's disease
Version: 
0 
Date: 
21 Nov 2021
Reviewer's report:
The authors should highlight the uniqueness of their study. Why is it important
for the discipline. There are several studies referred to this issue for example:
Hibi T, Hirohata S, Kikuchi H, Tateishi U, Sato N, Ozaki K, et al. Infliximab
therapy for intestinal, neurological, and vascular involvement in Behcet disease:
efficacy, safety, and pharmacokinetics in a multicenter, prospective, open-label,
single-arm phase 3 study. Medicine. 2016;95(24):e3863
Zou J, Ji DN, Shen Y, Guan JL, Zheng SB. Mucosal healing at 14 weeks predicts
better outcome in low-dose infliximab treatment for Chinese patients with active
intestinal Behcet's disease. Ann Clin Lab Sci. 2017;47(2):171-7
Tanida S, Inoue N, Kobayashi K, Naganuma M, Hirai F, Iizuka B, et al.
Adalimumab for the treatment of Japanese patients with intestinal Behcet's
disease. Clin Gastroenterol Hepatol. 2015;13(5):940-8.e3
Inoue N, Kobayashi K, Naganuma M, Hirai F, Ozawa M, Arikan D, et al. Long-
term safety and efficacy of adalimumab for intestinal Behcet's disease in the
open label study following a phase 3 clinical trial. Intest Res. 2017;15(3):395-
401
Vitale A, Emmi G, Lopalco G, Gentileschi S, Silvestri E, Fabiani C, et al.
Adalimumab effectiveness in Behcet's disease: short and long-term data from a
multicenter retrospective observational study. Clin Rheumatol. 2017;36(2):451-
5.
In the discussion please focus more on the comparison of your results to
previous studies and explain differences between them. 
Some important literature is missing
Park, Y., Cheon, J.H. Update on the Treatment of Behcet's Disease of the Small
Bowel with Biologic Agents. Curr Gastroenterol Rep 22, 24 (2020).
https://doi.org/10.1007/s11894-020-00759-1
Inoue N, Kobayashi K, Naganuma M, Hirai F, Ozawa M, Arikan D, Huang B,
Robinson AM, Thakkar RB, Hibi T. Long-term safety and efficacy of
adalimumab for intestinal Behçet's disease in the open label study following a
phase 3 clinical trial. Intest Res. 2017 Jul;15(3):395-401.
Sugimura N, Mizoshita T, Sugiyama T, Togawa S, Miyaki T, Suzuki T, Tanida
S, Kataoka H, Sasaki M. Real-world efficacy of adalimumab and infliximab for
refractory intestinal Behçet's disease. Dig Liver Dis. 2019 Jul;51(7):967-971.
Park J, Cheon JH. Anti-Tumor Necrosis Factor Therapy in Intestinal Behçet's
Disease. Gut Liver. 2018 Nov 15;12(6):623-632. 
Park YE, Cheon JH. Updated treatment strategies for intestinal Behçet's disease.
Korean J Intern Med. 2018;33(1):1-19. 
Vallet H, Riviere S, Sanna A, Deroux A, Moulis G, Addimanda O, Salvarani C,
Lambert M, Bielefeld P, Seve P, Sibilia J, Pasquali J, Fraison J, Marie I, Perard
L, Bouillet L, Cohen F, Sene D, Schoindre Y, Lidove O, Le Hoang P, Hachulla
E, Fain O, Mariette X, Papo T, Wechsler B, Bodaghi B, Rigon MR, Cacoub P,
Saadoun D; French Behçet Network. Efficacy of anti-TNF alpha in severe and/or
refractory Behçet's disease: Multicenter study of 124 patients. J Autoimmun.
2015 Aug;62:67-74.
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