JerMa88/BMC_Gastroenterology_Peer_Reviews huggingface dataset:
Review for 10.1186/s12876-023-03015-8 (2023)

Title: The clinical characteristics of focal acute pancreatitis based on imaging diagnosis:
comparison with non-localized acute pancreatitis- a preliminary result
Version: 2 Date: 25 Sep 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
No - there are major issues
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
No - there are minor issues
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Maybe - with major revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The authors raised an interesting clinical question related to
importance of focal pancreatitis. The study is retrospective, with the corresponding general
limitations.
REQUESTED REVISIONS:
The following comments may help improve the manuscript:
1. The laboratory diagnostic criteria for acute pancreatitis often include serum amylase or lipase
being at least 3 times above the upper reference limits. Please specify how many patients in each
group met this criterion for each pancreatic enzyme.
2. Please provide data on blood cancer biomarkers (e.g., CA 19-9) in the two groups. What
measures were taken to rule out premalignant pancreatic lesions (e.g., IPMN)?
3. Did the authors rule out autoimmune pancreatitis in the two groups?
4. Please specify in the methods section how exactly bloating and other symptoms were
diagnosed? Were the definitions standardized?
5. How many patients were transferred from another hospital?
6. How many patients required ICU admission?
7. Please specify at what point during hospitalization, CT was done? If there was more than 1
scan available for a give patient, which one was used?
8. Do the authors believe the diagnostic criteria for focal pancreatitis should be different from
non-localized pancreatitis?
Review for 10.1186/s12876-023-03015-8 (2023)

Title: The clinical characteristics of focal acute pancreatitis based on imaging diagnosis:
comparison with non-localized acute pancreatitis- a preliminary result
Version: 4 Date: 19 Oct 2023
Reviewer:  Konstantin A. Lesko
Reviewer's report:
I thank authors for improving the manuscript regarding my comments. I believe, all corrections
and modifications made article more  significant.
Review for 10.1186/s12876-023-03015-8 (2023)

Title: The clinical characteristics of focal acute pancreatitis based on imaging diagnosis:
comparison with non-localized acute pancreatitis- a preliminary result
Version: 4 Date: 26 Oct 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The authors have addressed my comments satisfactorily. The revised
manuscript is now sound.
Review for 10.1186/s12876-023-03022-9 (2023)

Title: Endovascular treatment of postoperative hemorrhage after pancreatectomy: A
retrospective study
Version: 0 Date: 12 Sep 2023
Reviewer:  Farzad Kakaei
Reviewer's report:
This is a well prepared article about a case series after PD and accepted as is. As you described
the cause of of bleeding in all of your patients is a leakage from biliary or pancreatic anastomosis
this leakages usually are mortal and bleeding is only a side effect of the laekages. When the
laekage is high output control of bleeding is not enough for saving the patient's life. Please
discuss more about this subject.
Review for 10.1186/s12876-023-03022-9 (2023)

Title: Endovascular treatment of postoperative hemorrhage after pancreatectomy: A
retrospective study
Version: 0 Date: 17 Sep 2023
Reviewer's report:
Review report
This study is a retrospective study, which aimes to examine the efficacy of a Viabahn stent graft
for bleeding after pancreatectomy. In this study, a total of 245 pancreatectomies were included.
PD was performed in 163 patients, DP in 75, and total pancreatectomy (TP) in 7. All six bleeding
cases occurred in PD patients. Bleeding sites were from a GDA pseudoaneurysm in three cases,
dorsal pancreatic artery, proper hepatic artery, and right hepatic artery. A Viabahn stent graft was
inserted for bleeding from the GDA pseudoaneurysm in all three cases. The result shows that all
three patients did not show any liver function abnormalities or hepatic blood flow disorders. One
patient with a Viabahn stent graft experienced re-bleeding, which required further management
to obtain hemostasis.
The significance of this article is to explore the therapeutic significance of a Viabahn stent graft
for PD patients with postoperative bleeding due to GDA pseudoaneurysm. However, there are
some shortcomings in this study. First, it was a retrospective study. Second, because of the small
sample size and the fact that the study was conducted at a single institution, the generalizability
of the results may be limited. In this study, there is no objective comparison between Viabahn
stent graft and traditional methods such as transcatheter arterial embolization (TAE).
The title reflect the main subject of the manuscript
The abstract summarize and reflect the work described in the manuscript
The key words reflect the focus of the manuscript.
The manuscript adequately describe the background, present status and significance of the study.
The manuscript describe methods in adequate detail
The manuscript interpret the findings adequately and appropriately, highlighting the key points
clearly.
The discussion shows the paper’s scientific significance sufficiently.
Tables are appropriately illustrative of the paper contents.
The manuscript cite appropriately the latest, important and authoritative references.
The style, language and grammar are accurate and appropriate.
Review for 10.1186/s12876-023-03022-9 (2023)

Title: Endovascular treatment of postoperative hemorrhage after pancreatectomy: A
retrospective study
Version: 4 Date: 24 Oct 2023
Reviewer's report:
The title reflect the main subject of the manuscript
The abstract summarize and reflect the work described in the manuscript
The key words reflect the focus of the manuscript.
The manuscript adequately describe the background, present status and significance of the study.
The manuscript describe methods in adequate detail
The manuscript interpret the findings adequately and appropriately, highlighting the key points
clearly.
The discussion shows the paper’s scientific significance sufficiently.
Tables are appropriately illustrative of the paper contents.
The manuscript cite appropriately the latest, important and authoritative references.
The style, language and grammar are accurate and appropriate.
Review for 10.1186/s12876-023-03021-w (2023)

Title: Healthcare service use in paediatric inflammatory bowel disease: a questionnaire on
patient and parent care experiences in Germany
Version: 1 Date: 25 Sep 2023
Reviewer's report:
Thank you for giving me the opportunity to review this article.
Aletta et al presented an assessment of healthcare service utilization within the realm of pediatric
inflammatory bowel disease (PIBD), a condition on the rise globally.
Prior to this investigation, no research had been conducted that specifically delved into
healthcare utilization patterns in the pediatric IBD field. The findings presented by Aletta et al.
hold significant value in enhancing the overall landscape of healthcare provision for PIBD.
Major points.
1. P7.160 -161
The authors have documented utilization rates concerning "nutritional counseling" and
"psychological counseling." Nonetheless, these specific terms were not expounded upon
within the methods section. It is imperative that these terms be elucidated within the method
section. Furthermore, a comprehensive exposition of the particulars pertaining to "nutritional
counseling" and "psychological counseling" would be greatly appreciated.
For example, dietitians involve “nutritional counselling” ?
2. Result:
P7.167-169
Patients diagnosed 3-4 years ago (OR 2.53 95% CI 1.08-5.97) and those diagnosed 5-6 years
ago (OR 2.66; 95% CI 1.02-6.91) were more likely to use nutritional counselling than those in
their first year after diagnosis.
P11,274-275
This idea was confirmed by the increased likelihood of not using services in the first year since
diagnosis.
In the context of patient diagnosis, it is generally imperative to furnish both patients and their
parents with disease education.
Is it a prevalent practice among pediatric gastroenterologists in Germany to omit the provision
of nutritional counseling to patients and their parents?
In various other countries, a collaborative approach is adopted, wherein dietitians collaborate
with pediatric gastroenterologists. The significance of nutritional counseling in the effective
management of patients with Crohn's disease (CD) cannot be overstated.
Please discuss regarding the necessary measures required to enhance the utilization of this crucial
service.
3. P9.213-214
The authors conducted a comparative analysis between individuals diagnosed within a 3-4-year
timeframe and those diagnosed over six years ago in the context of psychological services. The
rationale behind the selection of these specific time intervals by the authors warrants elucidation.
Additionally, it would be pertinent to explore the distinctions between individuals diagnosed
within the first year and those diagnosed after the initial year, in terms of their utilization of
psychological services.
Minor points.
1. P2. 35: Please correct “For PPIBD”.
2. P6. 153: “The average of ” # “mean” or “median” should be better.
3. P9.237: Please correct “18-year olds”.
Review for 10.1186/s12876-023-03021-w (2023)

Title: Healthcare service use in paediatric inflammatory bowel disease: a questionnaire on
patient and parent care experiences in Germany
Version: 3 Date: 29 Oct 2023
Reviewer's report:
The authors responded to my suggestions with great care and sincerity. I think it is very well-
revised. No further remarks from me.
Review for 10.1186/s12876-023-03000-1 (2023)

Title: Efficacy of endoscopic gastrojejunal bypass in obese Yucatan pigs: a comparative animal
study
Version: 1 Date: 19 Oct 2022
Reviewer:  Ivo Boškoski
Reviewer's report:
This is an experimental comparative study on four different types of endoscopic gastrojejunal
bypass in obese Yucatan pigs. Besides some small grammatical errors, the study has a valid
scientific concept ad brings novelty to treating obesity as a chronic, relapsing, multifactorial and
degenerative disease. Overall, this NOTES concept is of big importance.
Suggestions: it would be nice to have a graphical explanation of the complete endoscopic
procedure and figures in real life.
For better understanding, please insert a flowchart of the groups and relative numbers.
Review for 10.1186/s12876-023-03000-1 (2023)

Title: Efficacy of endoscopic gastrojejunal bypass in obese Yucatan pigs: a comparative animal
study
Version: 1 Date: 20 Mar 2023
Reviewer's report:
The authors showed the interesting results about a less invasive alternative to surgical gastric
bypass for obesity.
I have few comments.
1. In Fig3b, authors showed the picture meaning "Same picture magnification and showing mild
acute inflammatory changes in the central anastomotic areas."
I would like to see the picture of inflammatory lesions in high-power field and know how many
months after surgery was the autopsy performed.
If the inflammation occurring in the lesion was chronic or subacute, it could be  understandable
as surgical healing process. However, if it was acute, there might be other causes, such as blood
flow abnormalities after bypass or hyper-pressure on the GJA and so on.
2. I felt it was disappointing that many of the endocrine and metabolic studies have not been
performed. Since the number of experimental animals was small, I think it would be better to
show the data of each individual as a supplementary table.
Review for 10.1186/s12876-023-03011-y (2023)

Title: Evaluation of clinical efficacy, adverse reactions, and safety of PD-1 inhibitors combined
with chemotherapy when treating advanced gastric cancer
Version: 0 Date: 26 Aug 2023
Reviewer's report:
Dear Editor
This is a good manuscript reviewing “Synbiotic as an ameliorating factor in the health-related
quality of life in women with polycystic ovary syndrome. A randomized, triple-blind, placebo-
controlled trial”. The subject of the manuscript is fully consistent with the aims and scope of
the journal «BMC Women's Health».
The study was overall well-conducted and could be accepted after addressing the following
issues.
1- The study was overall well-conducted and could be accepted after addressing the following
issues.
2- Please write the full word when used for the first time in the text (line 7 &24).
3- How have completed the questioners by participant? What questions were asked and by whom
or face-to-face interview with trained researcher? Please explain in the method section.
4- Did dietary intake have evaluated such as a 24h food recall two times by research, in beginning
and end of the intervention.
5- The placebo and synbiotic sachets are described similar in packaging, texture and taste.
Perhaps a photo of the two forms of capsules could be added to the supplementary material so
readers can see how similar were. Please include packaging.
6- a photo of the two forms of capsules could be added to the supplementary material so readers
can see how similar were. Please include packaging.
7- How well does Synbiotic survive in the GI tract or is it absorbed quickly and acts systemically?
Perhaps more on ADME could be added to the introduction or discussion.
8- Is normal in a trial to get possible adverse effects such as headache or nausea that are reported
equally in both the placebo group and the test group. Were there really no possible adverse
effects or was it that there was no difference between the placebo group and the test group?
9- Do researcher see the Synbiotic really benefits the patients by limiting the symptoms.
10- This line implies no analysis using "intention to treat" statistics but this is mentioned
elsewhere so why not do ITT as well as the analysis reported?
11-  Please explain analyze the data both with and without these four patients. Did researcher
do no analysis using "intention to treat" statistics
12- The discussion section is too long to facilitate the understanding.
Review for 10.1186/s12876-023-03011-y (2023)

Title: Evaluation of clinical efficacy, adverse reactions, and safety of PD-1 inhibitors combined
with chemotherapy when treating advanced gastric cancer
Version: 0 Date: 05 Sep 2023
Reviewer's report:
Major comments:
1. The authors should first clarify the number of patients included. In the Abstract section:
‘Sixty-eight patients with advanced gastric cancer treated in our hospital from January 2020 to
December 2021 were randomly divided into study group (n = 45) and control group (n = 45).’
Therefore, 68 patients or 90 patients?
2. In the Results section, the authors stated that the deadline for follow-up was December 31,
2021. However, the authors included advanced GC patients in their hospital from January 2020
to December 2021.
3. In the General Information section: ‘In the research group, there were 20 males and 14
females.’ However, 45 patients were in the research group.
4. Table 1: DCR = CR+PR+SD? ORR = CR+PR? The ORR and DCR data were wrong.
5. Apatinib is a targeted agent rather than a chemotherapy agent. The main conclusion of this
manuscript was that PD-1 inhibitor combined with chemotherapy has been more effective when
treating patients with advanced GC. The conclusion was improper.
6. Table 7: The data were wrong. What were the other adverse events? Detailed grading should
be specified according to adverse events reporting requirements.
Based on the above alone, I lack confidence in the data in this manuscript. Publication seems
impossible unless the authors make convincing revisions.
Minor comments:
1. Were Figures 2 and 3 original to the authors?
2. Abbreviations were not used correctly in many parts of the manuscript.
Review for 10.1186/s12876-023-03011-y (2023)

Title: Evaluation of clinical efficacy, adverse reactions, and safety of PD-1 inhibitors combined
with chemotherapy when treating advanced gastric cancer
Version: 2 Date: 17 Oct 2023
Reviewer's report:
The authors made major revisions to the manuscript. The manuscript now appears to meet the
requirements for publication. However, I still have questions about the authenticity of the data
due to the large discrepancy between the initial manuscript and the revised manuscript. But it's
up to the editor to make the final decision.
Review for 10.1186/s12876-023-03025-6 (2023)

Title: Clinical features, treatments and prognosis of appendiceal bleeding: a case series study
Version: 1 Date: 11 Oct 2023
Reviewer's report:
A manuscript named "Clinical features, treatments and prognosis of appendiceal bleeding: a
case series" is interesting because this rare disorder is well documented as case series and visual
video is one of good diagnostic process, which will has of clinical value to readers.
However, case presentaions pp4 to pp9 are very cumbersome to read, then description of these
section should be condensed to be as short as half volume.
Review for 10.1186/s12876-023-03025-6 (2023)

Title: Clinical features, treatments and prognosis of appendiceal bleeding: a case series study
Version: 1 Date: 19 Oct 2023
Reviewer:  Konosuke Nakaji
Reviewer's report:
This is a case series of appendiceal bleeding cases in a single-center experience. It is an
exciting summary of rare GI tract diseases and worth reporting. However, there are several
concerns about this article. 1. Please note the name of the scopes uses hemostasis. 2. Are the
endoscopists all skilled? Please note the experience of the endoscopists. 3. The authors stated that
repeated flushing of the bleeding lesion was essential in conclusion. However, too much water
supply, such as a water jet, might make the manipulation difficult, especially in an emergency
endoscopy. They might not emphasize this.
Review for 10.1186/s12876-023-03007-8 (2023)

Title: Triglyceride Glucose-Waist Circumference: The Optimum Index to Screen Nonalcoholic
Fatty Liver Disease in Non-obese Adults
Version: 1 Date: 08 Dec 2022
Reviewer's report:
This article can give new insight for assesing NAFLD in non obese pts non invasively, for adition
may be from cost benefit  angle should be addresed in this article
Review for 10.1186/s12876-023-03007-8 (2023)

Title: Triglyceride Glucose-Waist Circumference: The Optimum Index to Screen Nonalcoholic
Fatty Liver Disease in Non-obese Adults
Version: 1 Date: 10 Dec 2022
Reviewer's report:
This is the study using indirect indicators to detect NAFLD from NHANES. There are some
major limitations here:
1. The definition of NAFLD:
(1)Since the spectrum of NAFLD is from simple steatosis (NAFL), NASH to fibrosis/cirrhosis,
using CAP >=249 db/m to define NAFLD can not provide sufficient information. Alternatively,
the outcome of NAFLD by CAP >=249 db/m can not include/exclude NASH or severe fibrosis,
which is the most vital indicator for current research and clinical follow-up.
(2)CAP refers the steatosis. However, the severity of steatosis is not any of the current parameters
of clinical survey/screening/or referral to a specialist.
2. The novelty of research: There are tons of published papers regarding indirect parameters
predicting NASH or severe fibrosis. Although the results of this manuscript support TyG, TyG-
BMI, TyG-WC, and TG/HDL-c can predict CAP >=249 (NAFLD), it can not provide the new
insights into the current knowledge of NAFLD. Moreover, from the viewpoint of MAFLD, these
metabolic factors are the risk factors and are highly related to NAFLD.
3. The definition of non-obese: The definitions of obesity by BMI should be various for different
ethnicities, especially for NHANES from the US.
Based on the significant limitation of above points 1 and 2, I will suggest the authors to re-
design the study.
Review for 10.1186/s12876-023-03007-8 (2023)

Title: Triglyceride Glucose-Waist Circumference: The Optimum Index to Screen Nonalcoholic
Fatty Liver Disease in Non-obese Adults
Version: 1 Date: 12 Jun 2023
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This is a ""classically"" executed NHANES secondary analysis
study aimed to find non-invasive biomarkers of NAFLD in non-obese populations. Study is
correctly designed and executed. There is one principal weakness in this study as it does not
compare performance of a proposed marker with other minimally invasive and validated markers
available in NHANES data (for example, but not limited to APRI)
REQUESTED REVISIONS:
Authors should augment their MS with a performance comparison for other known ""simple""
biomarkers of NAFLD (like APRI, etc.). Also, thorough proofreading in needed. More detailed
discussion concerning very high percent of Fibroscan NAFLD in NHANES cohort of non-obese
should be discussed. Differentiation with AFLD may be needed. Was it discussed in the literature
earlier? If so, need refs and explanations."
Review for 10.1186/s12876-023-03007-8 (2023)

Title: Triglyceride Glucose-Waist Circumference: The Optimum Index to Screen Nonalcoholic
Fatty Liver Disease in Non-obese Adults
Version: 4 Date: 07 Aug 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This is an interesting MS, and authors did good job on revision.
Simplified measures to access liver pathology are much needed in situations when biopsy is not
indicated (i.e. non obese adults).
ADDITIONAL REQUESTS/SUGGESTIONS:
pleas do small revisions for grammar and structure (MS does not need re-reviewing another
time).
"Fibroscan is a non-invasive way to assess hepatic steatosis [control attenuation parameters
(CAP)] and liver stiffness measurement" change to "Fibroscan is a non-invasive way to assess
hepatic steatosis [by control attenuation parameters (CAP)] and fibrosis [by liver stiffness
measurement  (LSM)].
"The correlations of CAP and LSM to the indexes were conducted by generalized linear models".
change to " "The correlations of CAP and LSM to the indexes were assessed by generalized
linear models."
"The positive association was existed between TG/HDL-c and TyG-WC  .." change to "The
positive association was detected for TG/HDL-c and TyG-WC "
"TyG-WC was positive related .." change to "TyG-WC were positively associated with ...
In Conclusion of Abstract, please chane past tense to Present tense  (were to are)
Review for 10.1186/s12876-023-03014-9 (2023)

Title: Prokinetics For the Treatment of Functional Dyspepsia: An Updated Systematic Review
and Network Meta-analysis
Version: 0 Date: 02 Sep 2023
Reviewer's report:
Subject: Feedback on the Report "Prokinetics For the Treatment of Functional Dyspepsia: An
Updated Systematic Review and Network Meta-analysis" by Qingqing Qi, Nana Wang, Han
Liu, and Yanqing Li
I had the opportunity to review the report titled "Prokinetics For the Treatment of Functional
Dyspepsia: An Updated Systematic Review and Network Meta-analysis" authored by Qingqing
Qi, Nana Wang, Han Liu, and Yanqing Li. Overall, I found the report to be well-written and
containing information that is highly relevant to the current state of research in this field.
The authors' analysis demonstrated a commendable level of quality, and their systematic review
and network meta-analysis provided valuable insights into the treatment of functional dyspepsia
with prokinetics. The research methodology appeared rigorous, and the results were presented
in a clear and organized manner.
However, there are a few areas where minor modifications are advisable. First, I would suggest
some improvements in language editing and attention to sentence structure to enhance the overall
readability of the report. Additionally,  it is important to maintain a consistent writing style
throughout the document, adhering to the third-person perspective.
In conclusion, I commend the authors for their valuable contribution to the understanding of
prokinetics in the treatment of functional dyspepsia. With some minor refinements in language
and writing style, this report has the potential to be an even stronger resource in the field.
Thank you for the opportunity to review this work, and I look forward to seeing its continued
development.
Review for 10.1186/s12876-023-02963-5 (2023)

Title: A Magnetic Resonance Imaging-Based Decision-Making Tool for Predicting Complex
Anal Fistulas Healing in The Early Postoperative Period
Version: 0 Date: 23 Jul 2023
Reviewer's report:
Dear authors,
I read your paper with great interest. I need to pose certain questions prior to considering for
acceptance, as below.
1. In your methodology, you have chosen to do the post operative MRI after the first stage
procedure post seton placement and not after the second stage procedure. It is the second stage
procedure which has greater impact on fistula recurrence, as it deals with addressing the internal
opening and often secondary tracts may be detected at this stage. So how do you explain the
benefit of doing the postoperative MR after the first procedure. Also the fistula healing is defined
after the second procedure.
2. How did you decide the time frame to do the postoperative MRI?
3. What is the cost effectiveness and clinical utility of doing this MRI? In any case, clinical
follow-up will determine the healing and action based on MRI is unlikely and may be futile.
4. Since the study was retrospective, the recording of alcohol intake was as a nominal data,
whereas it will be significant to know the extent of alcohol intake (as a ordinal variable) which
will actually help measure its relevance. So to include alcohol intake in the nomogram, doesn't
make sense. It can be utilised in a subsequent prospective study. In this study, it is a secondary
endpoint with poor reliance.
Regards,
Peer reviewer
Review for 10.1186/s12876-023-02963-5 (2023)

Title: A Magnetic Resonance Imaging-Based Decision-Making Tool for Predicting Complex
Anal Fistulas Healing in The Early Postoperative Period
Version: 2 Date: 06 Sep 2023
Reviewer's report:
According to the reviewer's comments, the author has made full and detailed revisions one
by one, and the professionalism and language level of the article have reached the publication
requirements of the journal. It is suggested that the article be published at a later date after
modification according to the typesetting requirements of the journal.
Review for 10.1186/s12876-023-02963-5 (2023)

Title: A Magnetic Resonance Imaging-Based Decision-Making Tool for Predicting Complex
Anal Fistulas Healing in The Early Postoperative Period
Version: 2 Date: 17 Sep 2023
Reviewer's report:
Dear Authors,
I have read the modified manuscript and find it satisfactory having addressed the points raised
by me in my initial assessment.
I recommend that the article can be accepted for publication.
Regards,
Peer reviewer
Review for 10.1186/s12876-023-03004-x (2023)

Title: Endoscopic Iatrogenic Esophageal Perforation and Management: A Retrospective
Outcome Analysis in the Modern Era
Version: 3 Date: 25 Sep 2023
Reviewer:  Kazuhiro Ota
Reviewer's report:
This manuscript showed retrospectivity the characteristics and outcomes of iatrogenic
esophageal perforation from the endoscopist's perspective. It is understandable that iatorogenic
esophageal perforation is an extremely rare incident during endoscopic procedures. The number
of cases is so small that no statistical considerations in detail have been conducted. From the
above, it is important to consider each case in more detail. The following modifications are
necessary to accept this paper.
Major comments
1. It is understandable that iatrogenic esophageal perforation requires immediate attention.  The
conclusion of this paper is that SEMS is effective. Please consider whether it is necessary to
consider the location and size of the lesion, the patient's background, and the procedure that
caused the prior condition in developing a treatment strategy for the IEP.
2. Please consider the background of patients to iatrogenic esophageal perforation and also
consider proactive measures for high-risk patients of IEP.
3. Please suggest a way to detect IEPs early. What were the symptoms and laboratory findings
of the patients you collected?
Minor comments
1. There is a case report of the esophageal perforation during endoscopic submucosal dissection
resulting in pyothorax. In this case, the esophagus and thoracic cavity had become entangled,
requiring not only closure with SEMS but also chest pain drainage (Ota K, et al. Temporary
insertion of a covered self-expandable metal stent to treat esophageal perforation due to
endoscopic submucosal dissection. Intern Med. 2015;54(9):1049-1052.). On the other hand,
in the case of delayed perforation of endoscopic submucosal dissection, the patient had a
mediastinal abscess, so surgical treatment was the treatment of choice (Iwatsubo T, et al. Very
Delayed Perforation after Esophageal Endoscopic Submucosal Dissection and Intralesional
Triamcinolone Injection. Case Rep Gastroenterol. 2022;16(2):462-468). As mentioned above,
each patient is likely to have a different treatment strategy, and each case should be fully
considered.
2. The supplementary file named “Raw Data" contains personal information.  Necessity of
deletion.
3. Please provide some images of typical cases.
Review for 10.1186/s12876-023-02999-7 (2023)

Title: Regular use of low-dose of Opioids after gastrointestinal surgery may lead to
Postoperative Gastrointestinal Tract Dysfunction in children: A Chinese national regional health
center experience sharing
Version: 3 Date: 03 Jul 2023
Reviewer's report:
The study is clinically relevant, rationale of the study, aims & objectives, inclusion & exclusion
criteria and methods of analgesics administration are well described.
There are some grammatical errors that need to be corrected
Review for 10.1186/s12876-023-02999-7 (2023)

Title: Regular use of low-dose of Opioids after gastrointestinal surgery may lead to
Postoperative Gastrointestinal Tract Dysfunction in children: A Chinese national regional health
center experience sharing
Version: 3 Date: 21 Aug 2023
Reviewer's report:
1.- The authors need to review the grammar in English
2.- Properly indicate the meaning of the abbreviations
3.- In the case of the patients who were eliminated from the studies, probably because of the
grammar used, it is not very understandable.
4. The conclusions and discussion can contribute more is too simple
Review for 10.1186/s12876-023-03005-w (2023)

Title: PVA enema ameliorates DSS-induced acute colitis in mice
Version: 1 Date: 16 Aug 2023
Reviewer:  Sumeet patiyal patiyal
Reviewer's report:
The authors have presented a very interesting and novel approach. They have  observed that
administering an aqueous solution of Polyvinyl alcohol at concentrations of 1 mg/ml and 3 mg/
ml led to a noteworthy reduction in weight loss among the colitis-affected group. Additionally,
there was a substantial enhancement in histopathology scores, along with a significant decrease
in the levels of inflammatory factors within the intestinal mucosal tissue. Furthermore, it was
established that PVA had the capacity to significantly amplify the count of colonic organoids in
an in vitro setting. However, I have the following comments:
1) "Furthermore, many children also suffer from this disease. This has seriously affected the
growth and development of children". This sentences seems like out of context, I would suggest
authors to provide a statistics along with relevant references.
2) Sentences in the Introduction seems incomplete at many places. Please check and rectify the
same.
3) Second paragraph of Introduction needs rearranging the sentences as the flow of sentences
is terrible.
4) Rewrite the following sentence:
"Nevertheless, there are also many and serious complications after the operation".
5) Please provide the full-form of SEM, as the audience could not be expert in statistics.
6) What is the rationale behind using the parametric test as ANOVA? Has authors checked the
distribution of their data.
7) I would suggest authors to provide more recent evidences support their claims.
8) A strong conclusion is recommended.
9) There are many grammatical and punctuation errors. Please lookout for them in the manuscript
and rectify them.
10) I I would suggest all the authors to read the manuscript thoroughly and make the flow
readable, as the present form of the manuscript is not up to the mark.
11) I failed to understand the motivation behind choosing the PVA. Kindly provide the same
in the introduction.
12) Have authors considered other bio materials too before choosing the PVA?
Review for 10.1186/s12876-023-03005-w (2023)

Title: PVA enema ameliorates DSS-induced acute colitis in mice
Version: 3 Date: 13 Sep 2023
Reviewer:  Maximilian Baumgartner
Reviewer's report:
The authors responded to all raised points and significantly improved their manuscript.
Before publication one issue remains:
In terms of statistics ANOVA was used to test if multiple groups differ in their means. According
to the authors t-tests were then used for pairwise comparison of groups. Has a correction for
multiple comparisons been applied if doing multiple t-tests ? If not, this should be stated in the
method section.
Minor comment: In the histology method section "What’s more," should be removed and the
sentence just started with " This assessment..."
Besides that I have nothing more to add.
Review for 10.1186/s12876-023-02996-w (2023)

Title: Statin Use and the Risk of Hepatocellular Carcinoma Among Patients With Chronic
Hepatitis B: An Emulated Target Trial Using Longitudinal Nationwide Population Cohort Data
Version: 1 Date: 07 Aug 2023
Reviewer's report:
1. The risk of hepatocellular carcinoma can be directly related to the degree of cirrhosis.
However, the percentage of cirrhosis and the severity of liver disease cannot be clarified among
the two groups.
2. A recent original article "Association of statin use with risk of liver disease, hepatocellular
carcinoma, and liver-related mortality" had been published on Gastroenterology and hepatology
2023 June 26 by Mara Sophie Vell et.al. Can the authors point the differences between the two
articles?
3. The authors concluded that statin might have a benefit for preventing HCC in CHB patients
with elevated cholesterol levels. However, further investigations should be done to clarify (1) if
more potent statins (i.e. rosuvastatin and atorvastatin) is recommmeded for chemo-prevention;
(2) the recommended cut-off value of cholesterol for chemo-prevention.
Review for 10.1186/s12876-023-02996-w (2023)

Title: Statin Use and the Risk of Hepatocellular Carcinoma Among Patients With Chronic
Hepatitis B: An Emulated Target Trial Using Longitudinal Nationwide Population Cohort Data
Version: 1 Date: 10 Aug 2023
Reviewer's report:
1. This study is a  good idea to find if statin use can reduce the recurrence risk of HCC.
2. From your data base, I think that you can find when the patient started statin use (in starin
use group). However, can you find when the patient "out" statin use ?(that means if the patient
discontinue the stain use after include into the in statin use group). In such condition, how do
you category this patient ?
Review for 10.1186/s12876-023-02996-w (2023)

Title: Statin Use and the Risk of Hepatocellular Carcinoma Among Patients With Chronic
Hepatitis B: An Emulated Target Trial Using Longitudinal Nationwide Population Cohort Data
Version: 1 Date: 23 Aug 2023
Reviewer:  Li-Hsuan Wang
Reviewer's report:
Overall, the content of the manuscript is very interesting, and the author addresses an important
issue. It is generally well-done. However, a few suggestions described below needs to be added
in detail:
1. Why author have to exclude patients have diagnosis on myocardial infarction, heart failure,
coronary heart disease, or revascularization? Are these diseases HCC risks?
2. Author how to choice concomitant medications? Why author not consider metformin effect?
3. In discussion section, author illustrate the studied cohort patients receiving antiviral therapy
proportion was very low (1%) and with relatively low HCC incidence rates (0.2~0.3 per 1,000
person-years). Does this condition meet the clinical situation? Author how to interpret result and
needs to be described in detail
Review for 10.1186/s12876-023-02996-w (2023)

Title: Statin Use and the Risk of Hepatocellular Carcinoma Among Patients With Chronic
Hepatitis B: An Emulated Target Trial Using Longitudinal Nationwide Population Cohort Data
Version: 1 Date: 24 Aug 2023
Reviewer's report:
In the manuscript, the authors repeatedly address the same statements. For example, the authors
said “The association between statin use and decreased HCC risk was consistent in all subgroups
analyzed”. Please avoid repeatedly stating the same arguments with the same sentences. Similar
mistakes can be readily seen.
The authors should check the manuscript carefully. There are some inconsistent data between
text and graphs. In 50 lines of the manuscript, the authors said “Fully adjusted HR.…0.93 (95%
CI: 0.74 to 1.16) for all-cause mortality”., where the CI is not consistent with that shown in
Table 2.
In 107 lines of the manuscript, the authors sequentially listed the inclusion criteria, but there
were duplicate numbers, which the authors should carefully check.
In 153 lines of the manuscript#the authors said “We emulated a pragmatic sequence of trials…
follow-up between biological and non-biological study arms ”. What are biological and non-
biological study arms#
The authors incorrectly calculated the total number of excluded patients in Figure 1. Please
correctly indicate the number of excluded participants.
The formulation of Table 2 should be improved. Please keep the table in the same typeface as
possible.
Review for 10.1186/s12876-023-02996-w (2023)

Title: Statin Use and the Risk of Hepatocellular Carcinoma Among Patients With Chronic
Hepatitis B: An Emulated Target Trial Using Longitudinal Nationwide Population Cohort Data
Version: 2 Date: 11 Sep 2023
Reviewer:  Li-Hsuan Wang
Reviewer's report:
Thank you for the author's reply. I have no recommendation.
Review for 10.1186/s12876-023-02996-w (2023)

Title: Statin Use and the Risk of Hepatocellular Carcinoma Among Patients With Chronic
Hepatitis B: An Emulated Target Trial Using Longitudinal Nationwide Population Cohort Data
Version: 2 Date: 13 Sep 2023
Reviewer's report:
The authors applied the "trial emulation" that accounted for measured differences between
treatment arms, and worked hard to prevent possible confounders. They concluded that
statins may have chemo-preventive effect for patients with chronic hepatitis B (CHB) with
dyslipidemia. Though the cut-off level of cholesterol and the timing of different statins
application need further investigation, the research may change the daily practice for CHB
patients.
Review for 10.1186/s12876-023-02996-w (2023)

Title: Statin Use and the Risk of Hepatocellular Carcinoma Among Patients With Chronic
Hepatitis B: An Emulated Target Trial Using Longitudinal Nationwide Population Cohort Data
Version: 2 Date: 23 Sep 2023
Reviewer's report:
The topic is interesting and important, but some details need to be revised.
In the manuscript, the authors said “Since study participants could have more than one exclusion
criteria, the final sample size was 1,379,708 nonunique individuals. Of those, 9,166 person-trials
were excluded due to missing information on confounding factors. The final sample size was
1,379,708 nonunique individuals”. This description is a bit redundant. Please avoid repeatedly
stating the same arguments with the same sentences.
Review for 10.1186/s12876-023-02996-w (2023)

Title: Statin Use and the Risk of Hepatocellular Carcinoma Among Patients With Chronic
Hepatitis B: An Emulated Target Trial Using Longitudinal Nationwide Population Cohort Data
Version: 3 Date: 11 Oct 2023
Reviewer's report:
Thank you for the author's reply. I have no recommendation.
Review for 10.1186/s12876-023-02997-9 (2023)

Title: Sex- and reproductive status-specific relationships between body composition and non-
alcoholic fatty liver disease
Version: 1 Date: 11 May 2023
Reviewer:  Honglu Yu
Reviewer's report:
The clinical significance of this article is limited. The authors said “WC has added value as
a more routine and simple measurement for the identification of NAFLD in men, and fat loss
and muscle gain are important strategies for the management of NAFLD in men. For post-
menopausal women, the important thing is to reduce visceral fat”. In clinical management,
the ways to change these data are all exercising, losing weight and controlling diets. How to
specifically manage patients with NAFLD in different gender and reproductive status.
In the Methods part of the Abstract section, the indicators measured by using FibroScan and
BIA should be given.
Because the authors used surrogate markers evaluating NAFLD severity, the study results may
be questioned.
In the Introduction section, the sentence “Therefore, NAFLD, gender and reproductive status,
and body composition are all interrelated and influence each other” is wrong, where the word
“influence” should be revised as “influenced”.
In the Study design and population part of the Patients and methods section, the name of the
hospital that conducted the study should be consistent with the hospital that the study approved
by the Ethics Committees.
In the Liver steatosis and fibrosis measurement part of the Patients and methods section,
the sentence “The measurement results were considered reliable when… was <30%” is
inconsistent with the reference 12 described that “The manufacturer recommends that successful
measurements be validated by using the following three criteria.
In the Body composition measurement part of the Patients and methods section, the sentence
“Visceral obesity was defined as VFA # 100 cm² in both genders” lacks references.
In the Collection of other clinical data part of the Patients and methods section, the authors said
“Only laboratory data obtained within 1 month of the FibroScan test were considered valid”.
How do the authors decide the time as “within 1 month”?
In the Table S2, the unit of “Age” should be revised as “years”.
The values of “ALT”, “AST”, “AKP”, and “GGT” are incredible. Clinically, these values are
generally decimals rather than integers.
What is the meaning of “E”?
The authors should check the position of the inserted references throughout this article. The
inserted references should be placed before periods.