Review for 10.1186/s12876-021-01901-7 (2021)

Reviewer’s report
Title: 
Tri-Modal Management of Primary Small Cell Carcinoma of the Pancreas
(SCCP): a Rare Neuroendocrine Carcinoma (NEC)
Version: 
0 
Date: 
17 May 2021
Reviewer's report:
This manuscript described about a case of primary small cell carcinoma of the
pancreas (SCCP) which was treated with neoadjuvant multi-agent chemotherapy
combined with radiotherapy and surgery. Authors selected a neoadjuvant
approach in this case due to the high possibility of relapse rate by upfront
surgical resection. As a result, the patient remains stable 18 months of survival.
Authors concluded that surgery after neoadjuvant chemotherapy and
radiotherapy may improve prognosis and overall survival in appropriate
candidates.
Although this case report seemed to be interesting in point of rarity of the disease
and treatment strategy, several questions and concerns remain. 
1. I wonder if "next generation sequencing" would not be needed in the title?
These results of next generation sequencing are interesting, but these were not
reflected in the treatment strategy of this case. Please reconsider the title.
2. The abstract of "cover page" and "manuscript page" are different. Please check
the text itself.
3. What kind of population are "appropriate candidates" for surgery after
neoadjuvant chemotherapy and radiotherapy? Do you have any plans in case of
future recurrence of tumor? Please discuss this point. 
4. In the preoperative surgical strategy, did authors plan for combined resection
of portal vein or SMV? In the image (Fig 1 and 2), the location of tumor in
uncinate process of pancreas and involvement of SMV is difficult to understand.
Please indicate the location and range of tumor in the CT image and consider a
coronal section view.
5. The image of EUS is hard to understand. Please indicate the location of the
tumor and SMV.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
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Yes
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from apparent manipulation?
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