Review for 10.1186/s12876-021-02019-6 (2022)

Reviewer’s report
Title: 
Challenges in treatment of a patient suffering from neuroendocrine tumor
G1 of the hilar bile duct: a case report
Version: 
0 
Date: 
17 Jun 2021
Reviewer: 
Tomoyuki Abe
Reviewer's report:
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The authors present a well-written work examining the Challenges in treatment
of a patient suffering from neuroendocrine tumor G1 of the hilar bile duct: a case
report. It is well-written and worth for the publication. However, limitations of
the study indeed exist and are appropriately recognized, and the preliminary
nature of the study is recognized.
1. Please describe the preoperative diagnosis. In case of perihilar bile duct
cholangiocarcinoma, ERCP and POCS are required to exam the tumor spread.
Bile juice cytology and step biopsy for determining the operation type should be
added in the case presentation section.
2. Why you did not perform hepatectomy with bile duct resection? This case
seems to be type II Bismuth or type IV from MRCP, for curative resection hemi-
hepatectomy with caudal resection is necessary. Please clarify the operative
procedure and tumor stage. 
3. Some study revealed that percutaneous transhepatic biliary drainage was
identified as an independent negative predictor of survival in patients with
perihilar cholangiocarcinoma. 
How do your treat patients with perihilar
cholangiocarcinoma for preoperative biliary drainge?
#1. Komaya K, et al Verification of the oncologic inferiority ofpercutaneous
biliary drainage to endoscopic drainage: apropensity score matching analysis of
resectable perihilarcholangiocarcinoma.Surgery2017;161: 394-404.
#2. Ebata T, et al Surgical resection for Bismuth type IV
perihilarcholangiocarcinoma DOI:10.1002/bjs.10556
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