Review for 10.1186/s12876-017-0649-y (2017)

Reviewer ’s report  
 
Title:  A superficial esophageal cancer in an epiphrenic diverticulum treated by endoscopic 
submucosal dissection  
 
Version: 0 Date: 10 Jun 2017 
 
Reviewer:  YoenYoung  Chuah  
 
Reviewer’s report:  
 
Fu and colleagues submitted their work entitled "A superficial esophageal cancer in an 
epiphrenic diverticulum treated by endoscopic submucosal dissection" to the BMC 
Gastroenterology. Overall, this is an interesting case that could provide education purpo se to the 
other gastroenterologist of the use of white light and NBI for detecting early cancer even in some 
unusual structure during endoscopic surveillance. Furthermore, ESD may provide a relatively 
less invasive method to cure early cancer in esophagus even in a diverticular site.   
 
This paper is interesting and well -written but I have some concerns.  
 
Will the risk of perforation be increased if endoscopic submucosal dissection(ESD) were to 
perform on epiphrenic diverticulum compared to the other part o f esophagus? What risk 
stratification was taken before the procedure?  
 
Fluoroscopy may a good radiographic method for differentiating pseudodiverticulum from 
diverticulum. Do you perform fluoroscopy before ESD?  
 
Will the risk of perforation be increased if the cancer lesion were on pseudo -diverticulum? What 
had been done to differentiate these two (true and pseudo - diverticulum) before the procedure?  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
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