Review for 10.1186/s12876-021-01694-9 (2021)

Reviewer’s report
Title: 
Endoscopic resections for superficial esophageal squamous cell epithelial
neoplasia: Focus on histological discrepancies between biopsy and resected
specimens
Version: 
1 
Date: 
21 Dec 2020
Reviewer's report:
It is an important study for determining the histological differences in diagnosis
of esophageal cancer.
- The time gap between biopsy and resection is important as it can affect the
final outcome of this study. As it retrospective data, this time lag should have
been mentioned in final analysis. Also the median time of this lag should be
comparable.
- The median size per biopsy that is likely to give discordant histopathology can
be calculated and would have important clinical implications.
-What about those patients who needed repeat biopsies? Piece meal dissections?
Any patients with hidden focus of malignancy ?
MINOR CORRECTIONS- 
- Define Upper, Mid and Lower esophagus in methods
- 'The prognosis of patients suffering from esophageal cancer was dependent on
tumor stage,
five-year-survival rate for advanced esophageal cancer is around 10-20%, but
can exceed 90% for early-stage asymptomatic esophageal cancer'
-'Endoscopy screening decreases incidence and mortality of esophageal cancer
for detection and management of early stage ESCC and precancerous lesions'
-'Forceps biopsy and endoscopic resected specimen were fixed, embedded, and
cut.
-Make it a separate sentence- 'If the pathological diagnosis was inconsistent,
agreement was achieved by discussion.'
- Omit Detaily- 'Three HGIN or ESCC lesions were diagnosed as negative of
neoplasia in pretreatment biopsy'
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
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Yes
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Yes
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from apparent manipulation?
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