Review for 10.1186/s12876-020-01243-w (2020)

Reviewer ’s report  
 
Title: Increased circulating total bile acid levels were associated with  organ failure in patients 
with acute pancreatitis  
 
Version: 1 Date: 28 Feb 2020  
 
Reviewer: Atsushi Irisawa  
 
Reviewer's report:  
General comments (Reviewer #1)  
Thank you for the response to the peer review. Most of my questions have been corrected and 
resolved.  
 
However, I think total bile acid (TBA) is deeply related to the liver disease. You added about 
fatty liver and alcoholic liver injury in the revised manuscript. Please consider whe ther other 
patients have the liver disease, such as cirrhosis or primary biliary cholangitis (PBC) in this 
study.  
In addition, I think Table1 is hard to see. Please take measures such as splitting the table.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
No 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I am abl e to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to al l of the above, write 'I declare that I have  no competing interests ' 
below. If your reply is yes to any, please give details below.  
 
I declare tha t I have no competing interests  
 
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