Review for 10.1186/s12876-022-02132-0 (2022)

Reviewer’s report
Title: 
Are Gastrointestinal Symptoms Associated with Higher Risk of Mortality
in COVID-19 Patients? A Systematic Review and Meta-Analysis
Version: 
1 
Date: 
26 Dec 2020
Reviewer: 
Mario Lima
Reviewer's report:
Dear Editor,
The Authors' of "Are Gastrointestinal Symptoms Associated with Higher Risk of
Mortality in COVID-19 Patients? A Systematic Review and Meta-Analysis"
present a Systematic Review and Meta-Analysis of studies in literature in order
to determine if GI symptoms could be predictive values of worse COVID-19
disease outcome.
The study is well written and structured and comes to important conclusions.
Moreover, considering the novelty of this disease, Meta-analysis are essential to
summarize single experiences that, taken alone, could be statistically inadequate
to describe the clinical evolution of SARS-CoV-2 disease.
Therefore, I consider this work worthy of publication by your Journal.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
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Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes