Review for 10.1186/s12876-022-02454-z (2022)

Reviewer’s report
Title: 
Natural history of intracholecystic papillary neoplasm (ICPN); a rare case
of ICPN whose natural history was closely followed by ultrasound.
Version: 
0 
Date: 
18 Apr 2022
Reviewer: 
Faten Limaiem
Reviewer's report:
The title reflects the main subject of the manuscript
The abstract summarizes and reflects the work described in the manuscript.
The key words reflect the focus of the manuscript.
The manuscript adequately describes the background, present status and
significance of the study.
The manuscript interprets the findings adequately and appropriately, highlighting
the key points concisely, clearly and logically.
ICPN includes mass-forming (papillary or polypoid), intramucosal and
preinvasive gallbladder neoplasms larger than one cm. In the present case, the
polyp measures 1 cm.
In the introduction, the authors should rather mention the latest 2019 WHO
classification 
The histological figures in the manuscript do not show major atypia and high
grade dysplasia, the authors should add histological figures showing major
atypia (higher magnification).
How could you explain the slight positive staining of p53 and MIB1 in a high
grade dysplastic polyp ?
In the discussion section, the authors should precise the exact definition of high-
grade BilIN and the differentiation of high-grade BilIN and ICPN according to
the 2019 WHO classification.
*** The style, language and grammar are not accurate and appropriate. We
noticed the presence of several typographical mistakes.Thus, extensive English
language editing is mandatory. A sentence does not begin with an abbreviation.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
No
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes