Review for 10.1186/s12876-021-01779-5 (2021)

Reviewer’s report
Title: 
Assessment and management of Undifferentiated Carcinoma with
Osteoclastic like Giant Cells of the Pancreas: A Case Report and revision of
literature
Version: 
0 
Date: 
28 Dec 2020
Reviewer's report:
This paper reports "Assessment and management of Undifferentiated Carcinoma
with Osteoclastic like Giant Cells of the Pancreas". Undifferentiated Carcinoma
is a rare tumor, but we sometimes meet this type of the tumor. Published cases
are small numbers, but in the clinical situation, it is not so much rare. So, authors
have to show new knowledge of this tumor in this paper. 
1. Authors showed IHC staining and gene analysis, but these examinations are
not specific for Undifferentiated Carcinoma, and not so useful for diagnosis and
treatment selections for this tumor. So, if possible, authors should show the
specific markers for diagnosis and treatment. It is very important for readers.
2. What are the prognostic factors? Authors mentioned the poor prognosis in this
tumor. Operation is the best treatment? For example, pancreatic NECs are also
poor prognosis tumors. First line treatment for NECs is not always surgery. 
3. Scale is needed in the pathological findings.
4. Macroscopic findings after formalin fixative and loupe statues (low
magnification) are useful to understand this lesion. Please show them.
5. If unresectable cases, can we diagnose this type of the tumor by EUS-FNA?
Big surgical specimens are necessary? Please consider and discuss. 
6. Please show the laboratory examinations of all tumor makers. 
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