Review for 10.1186/s12876-020-01486-7 (2020)

Reviewer’s report
Title: 
Development of significant disease in a cohort of patients with non-
specific enteritis on capsule endoscopy. Clinical suspicion and a high base line
Lewis score are predictive of Crohn’s disease.
Version: 
0 
Date: 
13 Jun 2020
Reviewer's report:
This manuscript investigates the course of non-specific enterocolitis detected by
capsule endoscopy. There are several arguments in this manuscript.
It is unclear why a case of clinically suspected Crohn's disease with a high Lewis
score would necessarily lead to a diagnosis of nonspecific enterocolitis.
Please clarify the authors' criteria for the diagnosis of Crohn's disease.
Also, please describe the rationale for the diagnosis of non-specific enterocolitis
in cases with clinically suspected Crohn's disease and a high Lewis score.
If the exclusion criteria define NSAID users, then 12 of the 88 NSAID users in
this study should also be excluded.
In addition to NSAIDs, other drugs known to cause mucosal injury include
aspirin.
The authors should exclude these drugs in their exclusion criteria for this study.
Please clarify the authors' diagnostic criteria for IBS.
Please provide the rationale for the diagnosis of IBS in cases where nonspecific
enterocolitis was present.
Is a 2-year observation period sufficient in clarifying the natural history of
nonspecific enterocolitis?
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
No
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the
authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you
recommend an additional statistical review?
If an additional statistical review is recommended, please specify what aspects
require further assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Acceptable
Declaration of competing interests
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