Review for 10.1186/s12876-021-01761-1 (2021)

Reviewer’s report
Title: 
Plasma interleukin-17 and alpha-fetoprotein combination effectively predicts imminent
hepatocellular carcinoma occurrence in liver cirrhotic patients
Version: 
1 
Date: 
07 Feb 2021
Reviewer: 
Rong Jun Guo
Reviewer's report:
The authors have tried to address my concerns. 
Unfortunately, they do not have 
tumor tissues preserved in
their prospective cohort for comparison between tissue expression of IL17 and AFP and their serology
levels.
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Is the study design appropriate to answer the research question (including the use of appropriate controls),
and are the conclusions supported by the evidence presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free from apparent
manipulation?
Yes