Review for 10.1186/s12876-022-02406-7 (2022)

Reviewer’s report
Title: 
The impact of serum thyroid-stimulation hormone levels on the outcome
of hepatitis B virus related acute-on-chronic liver failure: an observational study
Version: 
4 
Date: 
29 May 2022
Reviewer's report:
The grouping are not clearly stated in the methodology. It is difficult to follow
the trend of thought of the authors. The following issues were not answered:
Regarding TABLE 1: Demographics show differences in p-value, meaning
Baseline characteristics are not comparable. Moreover, the patients in Group III
had more treatment than those in Group I and II. Knowing this affects the risk of
decompensation, will it also affect the conclusion. 
May i know if confounders were addressed and how this has affected the
conclusion. Reading through it, there seems no explanation to address this
especially since it is only single point determination of the thyroid hormones.
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