Review for 10.1186/s12876-021-01660-5 (2021)

Reviewer’s report
Title: 
A Randomised Placebo Controlled Trial of VSL#3® Probiotic on
Biomarkers of Cardiovascular Risk and Liver Injury in Non-alcoholic Fatty
Liver Disease
Version: 
1 
Date: 
28 Sep 2020
Reviewer's report:
The authors carried out an interesting study to investigate 
the effects of VSL#3®
Probiotic 
supplementation 
on biomarkers of cardiovascular risk and liver injury
in non-alcoholic fatty liver disease. The data is very robust. I have few
comments here:
1) What is the clinical significance of this study? what is the clinical perspectives
of VSL#3? Please discuss further.
2) Could the authors discuss the molecular mechanisms of the effects of
VSL#3® Probiotic further to make it clearer?
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
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Yes
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