Review for 10.1186/s12876-020-01196-0 (2020)

Reviewer’s report
Title: Real-world effectiveness and safety of sofosbuvir and nonstructural protein 5A inhibitors
for chronic hepatitis C genotype 1, 2, 3, 4, or 6: a multicentre cohort study
Version: 0 Date: 03 Jan 2020
Reviewer: Sunil Taneja
Reviewer's report:
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This is a big data collection of different Hepatitis C patients treated at multiple centres. 
Howver a few points need clarification.
The  study  population  is  variable  includes  patients  with  HCC-  Stage  of  HCC  has  not  been
mentioned,whether treated or not? what type of treatment offered? and was HCV treatment offered
before or after treatment of HCC
The second group of CKD has also been described. What was the dosing schedule of Sofosbuvir used
in various stages of CKD. what was the adverse affect profile in this group.
The Third group is HCV and HBV coinfection.- whatw as the status of hepatitis B at the start of
treatment and what antivirals were being used in Hepatistis B. Did we look at the interactions?
The fourth group is HCV and HIV coinfection. What was the status of HIV , what regimens were being
used for HIV. Was there any interactions?
The fifth group is cirrhosis- what was the dosing and duration of drugs. since ribavirin was used was
the adverse affect profile different?
The sixth group is treatment experienced- What was the treatment which they had already received and
did we look at RAVs
The seventh group is post liver transplantation patients.-What treatment regimen were used? what
immunosuppressive  medication  was  being  used?  what  were  the  interactions  with  the
immunosupprsssive drugs and what were the side effects
 
Why was the genotype I treated primarily with SOF+ Dacla when the recommended drug is SOF+ Ledi
12 week, 16 week and 24 week treatment  has been done however it has not been specified.
How many patients of Cirrhosis underwent liver biopsy?
The uniformity of the study population is not there and it becomes difficult to understand the paper.
There are lot of grammatical mistakes which need correction.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
No
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
No
Are you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?
If an additional statistical review is recommended, please specify what aspects require further
assessment in your comments to the editors.
I recommend additional statistical review
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
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