Review for 10.1186/s12876-021-01875-6 (2021)

Reviewer’s report
Title: 
Vedolizumab combined with surgical resection successfully treated
perforating Crohn’s disease with peritoneal space to rectal and vaginal fistulas: a
case report
Version: 
0 
Date: 
26 May 2021
Reviewer's report:
Thanks for submitting this interesting and challenging case. We see complex
penetrating Crohn's disease often and such patients are challenging to manage.
1. Given larger body of evidence for anti TNF therapy in fistulizing Crohn's
disease, why was anti TNF therapy not chosen as initial choice? While I
understand concern for infection, often once abscess/phlegmon is drained, anti
TNF therapy use has been shown to be safe concurrently or after antibiotic
therapy. 
2. Any concern with vedolizumab taking longer to act and achieve remission
compared to infliximab?
3. Based on available data, kindly mention that evidence still favors anti TNF
therapy, given paucity of evidence with vedolizumab for such cases, however
may suggest that such cases call for larger studies with vedolizumab in complex
fistulizing Crohn's disease.
4. Instead of tazocin,suggest using generic name.
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