Review for 10.1186/s12876-017-0596-7 (2017)

Reviewer ’s report  
 
Title:  Comparison of the long -term efficacy between entecavir and tenofovir in treatment - naïve 
chronic hepatitis B patients  
 
Version: 0 Date: 15 Oct 2016 
 
Reviewer:  Dechun  Feng  
 
Reviewer’s report:  
 
In this manuscript, the authors studied the long -term efficacy between entecavir and tenofovir in 
treatment naïve chroni c hepatitis B patients. Overall, there is no big problems in the design of the 
study and the analysis of the results. However, there are several published the studies with very 
similar design and results with this manuscript. Such as Int J Infect Dis. 2014  Nov;28:153 -9,  
 
Biomed Res Int. 2016;2016:6725073,  
 
Mem Inst Oswaldo Cruz. 2016 Apr; 111(4): 252 -257.  
 
Farm Hosp. 2016 Jun 1;40(4):279 -86.,  
 
Clin Microbiol Infect. 2016 Jan;22(1):95.e1 -7,  
 
Int J Clin Exp Med. 2015 Jan 15;8(1):666 -73,  
 
Eur Rev Med Pharmacol  Sci. 2013 Sep;17(18):2467 -73.  
 
Hepatogastroenterology. 2012 Mar -Apr;59(114):477 -80. 
 
So the current study may lack of novelty.  
 
Are the methods appropriate  and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review  is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do yo u hold or are you currently applying for any patents relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript ? 
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the  above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
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on my report to the authors and, if the manuscript is accepted for publication, my named report 
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to the editors, which will not be published . 
 
I agree to the open peer review policy of the journal