Review for 10.1186/s12876-020-01521-7 (2020)

Reviewer’s report
Title: 
Serum Hydroxybutyrate dehydrogenase as an early predictive marker of
the severity of acute pancreatitis: a retrospective study
Version: 
0 
Date: 
25 Aug 2020
Reviewer's report:
This article reports an early marker for predicting the severity of acute
pancreatitis, which has good innovation and clinical value. But there are some
problems in the article that require the author to explain or modifyThe abstract
does not clearly describe the purpose of the study
1.AUC=77.8% in the abstract is an expression error, it should be AUC=0.778
2.This article studies the early predictive value of HBDH, but the included
patients did not describe that they were admitted to the hospital at the early stage
of AP, and should be stated in the inclusion criteria.
3.The classification of SAP is inaccurate, "local or systemic complications which
last longer than 48 hours" does not belong to the definition of SAP.
4.In Figure 1 of this article, the highest Ranson score is 4-5 points, and the total
score of Ranson score is 11 points. Please explain whether the points are
calculated 48 hours after admission.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
No