Review for 10.1186/s12876-022-02102-6 (2022)

Reviewer’s report
Title: 
Malignant rhabdoid tumor of the liver in a middle-aged woman: a case
report and literature review
Version: 
1 
Date: 
14 Jul 2021
Reviewer's report:
PEER REVIEWER ASSESSMENTS: 
RELEVANCE - Does this case report make a contribution to medical
knowledge, have educational value, or highlight the need for a change in clinical
practice or diagnostic/prognostic approaches? 
Yes, this report contributes to medical knowledge
CASE DESCRIPTION - Are the details of the case sufficiently well described to
understand the patient's symptoms and course of treatment? 
No - there are major issues
DIAGNOSIS/INTERPRETATION - Based on the facts presented, are the
diagnosis, interpretation, and course of treatment medically sound?
Yes, the work described is medically sound
DISCUSSION OF THE CASE - Does the discussion appropriately analyse the
importance of the findings and their relevance to future understanding of disease
processes, diagnosis or treatment? Has an adequate literature review pertinent to
the case been included?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Could an appropriately REVISED
version of this work represent a technically sound contribution?
Maybe - with major revisions
PEER REVIEWER COMMENTS: 
GENERAL COMMENTS: Interesting case, but the clinical aspects need to be
written more clearly, however, the molecular basis of the tumor (SMARCB1) is
nicely described in the discussion.
REQUESTED REVISIONS: 
1. clinical aspects need to be written more clearly eg did she present with rupture
and you managed conservatively initially?
2. did you consider embolic therapy as bridge
3. radiology images need to be better quality
4. legends of radiology need to be expanded on eg the appearances of the tumor
5. would state if cases described in the literature and in your case that
background liver was non cirrhotic and hormonal status in females
6. you allude to interval imaging been done, how often
7. what is your standard genetic panel that you do for primary liver cancer work
up? Is SMARCB1 part of that panel, if not why did you test for it?
8. would go into a bit more depth regarding surgery eg did you go straight to
open or laparoscopic approach, and what type of hepatectomy?
9. you describe that because of poor condition of the patient at discharge, she
was not given systemic therapy. What happened? Did she have surgical
complications leading to a protracted in patient stay? 
10. I am curious what traditional chinese medicine is she receiving and have you
any follow up scans to see effect on tumor
11. throughout the manuscript you refer to the genetic profile of the tumor being
used to inform decision making in systemic therapies. maybe keep this in the
discussion alone, unless this is your standard clinical practice?
ADDITIONAL REQUESTS/SUGGESTIONS: 
The case is interesting and some of the points the authors make. But the clinical
description of the case is not clear at all.
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