Review for 10.1186/s12876-020-01471-0 (2020)

Reviewer’ s report
Title: Peritumoral ductular reaction can be a prognostic factor for intrahepatic cholangiocellular
carcinoma
Version: 3Date: 26 Aug 2020
Reviewer's report:
1. The authors should emphasize the 'field effect' on the carcinogenesis of ICC by their results.
2. The limitations of this study should be stated explicitly.
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Is the study design appropriate to answer the research question (including the use of appropriate
controls), and are the conclusions supported by the evidence presented?
YesAre the methods sufficiently described to allow the study to be repeated?Yes
Is the use of statistics and treatment of uncertainties appropriate?
YesIs the presentation of the work clear?YesAre the images in this manuscript (including electrophoretic gels and blots) free from apparent
manipulation?
Yes