Review for 10.1186/s12876-018-0850-7 (2018)

Reviewer ’s report  
 
Title: Mesenchymal Stem Cell Transplantation Improves Chronic Colitis -Associated 
Complications through Inhibiting the Activity of Toll -Like R eceptor -4 in Mice  
 
Version: 0 Date: 12 Dec 2017  
 
Reviewer: Alba Rodriguez Nogales  
 
Reviewer's report:  
 
Please include all comments for the authors in this box rather than uploading your report as an 
attachment. Please only upload as attachments annotated versions of manuscripts, graphs, 
supporting materials or other aspects of your report w hich cannot be included in a text format.  
Please overwrite this text when adding your comments to the authors.  
The authors aimed to investigate the effects of Mesenchymal Stem Cell Transplantation, in an 
experimental model of colitis in mice. The choice of  methods is correct , please specify :  
The procedure to evaluate the presence of gross blood in the faces.  
Distilled water was added to control mice?  
Although, statistical test applied statistical significance is appropriate, it is necessary to show the 
statistic differences between all groups.  
The fig.1 does not show the statistic differences.  
Do you calculate the mice mortality??  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include th e necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
  
Are you able to asse ss any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I recommend additional statistical review  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
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1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares  in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you recei ved reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
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below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
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