Review for 10.1186/s12876-020-01210-5 (2020)

Reviewer ’s report  
 
Title: Prophylactic clip application for large pedunculated poly ps before snare polypectomy may 
decrease immediate postpolypectomy bleeding  
 
Version: 0 Date: 12 Sep 2019  
 
Reviewer: Julajak Limsrivilai  
 
Reviewer's report:  
 
This is a prospecti ve study investigating role of prophylactic clip application for large 
pedunculated polyps before snare polypectomy. Please see my comments below;  
 
 
1. Although there are many studies including one article in press of Gastroenterology 
(Feagins LA et al.) c oncluding that prophylactic clip was not associated with rate of post -
polypectomy bleeding, I think this study, which included only large pedunculated polyps, 
still provides useful information. Generally, there are nourishing blood vessels in the 
stalk of the pedunculated polyp, and their diameter depends on the size of the polyp and 
the diameter of the stalk. Therefore, they are different from sessile polyps. I suggest 
adding this information in the discussion.  
 
 
2. Were all patients in the intervention arm  (group A) technically successfully placed the 
clips? Was there any protocol in making decision how many clips would be placed?  
 
 
3. Why 4 mm thickness of stalk was used to categorize the patients in univariate analysis?  
 
 
4. The stalk diameters in group B r anged from 1 - 10 mm while the diameters in group A 
was 1 -5 mm. Although there was no significant difference, this might have caused effect 
when trying to determine the benefit of prophylactic clip. Could the authors try to do 
multivariate analysis? Also, the results should be included in the manuscript, not in 
supplementary documents.   
 
 
 
 
 
 
 
 
 
 
Are the methods appropriate and well described?  
If not, pleas e specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately suppo rted by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an a dditional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publi cation of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you curr ently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any  other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
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