Review for 10.1186/s12876-022-02308-8 (2022)

Reviewer’s report
Title: 
Unusual presentation of extra-nodal double-hit follicular lymphoma: a
case report
Version: 
0 
Date: 
12 Mar 2022
Reviewer's report:
Unusual presentation of extra-nodal double-hit follicular lymphoma: a case
report
The authors reported the first case of follicular lymphoma with double-hit
cytogenetics with primary extra-nodal presentation (primary colonic follicular
lymphoma). The authors should be commended on their work. There are a few
areas where additional information would enhance the manuscript.
1. Abbreviations should be spelled out on first use in both the abstract and main
text and then used consistently after that.
2. As the author described, "sessile polypoid lesion of 0,5 cm of the sigmoid
colon" was unformal. It would be better if the authors changed it to "0.5 cm" or
"5 mm".
3. Before giving the final diagnosis of "primary colonic localization of follicular
lymphoma," the authors evaluated the upper and mid gastrointestinal tract (such
as Esophagogastroduodenoscopy, enteroscopy, or video capsule enteroscopy) or
not?
4. On lines 60-61, the author described "double-hit follicular lymphoma or triple-
hit follicular lymphoma (DHFL)." Please recheck this abbreviation.
5. What did "DHL" (on lines 62) mean? 
6. Because the pathologic finding in this patient was compatible with follicular
lymphoma (which is the indolent type of lymphoma) and there was no feature of
the aggressive type of lymphoma, the use of fluorescent in-situ hybridization
(FISH) studies of MYC and BCL2 rearrangement is unusual. It would be more
impressive if the authors provided the reason or hint of the application of these
FISH rearrangements study. 
7. Did the author proceed Ki-67 immunohistochemistry for assessing the
proliferative index in this case?
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
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from apparent manipulation?
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