Review for 10.1186/s12876-022-02432-5 (2022)

Reviewer’s report
Title: 
Gastric carcinosarcoma with FGFR2 amplification under long-term
control with pazopanib: A case report and literature review
Version: 
0 
Date: 
10 May 2022
Reviewer: 
Yuichiro Miki
Reviewer's report:
The authors reported a very rare case with gastric carcinosarcoma. The paper is
quite well written, and should be interesting to the readers of this journal.
There are some minor points to be modified before the publication.
1. The reason why the authors selected pazopanib after the treatment failure of
nivolumab is not clearly described. Please add some comments in the discussion.
2. Which specimens (primary or liver?) was used for Oncopanel System? Please
add the information.
Primary tumor was diagnosed as well to moderately differentiated
adenocarcinoma, while the liver metasitasis was moderately to poor
differentiated adenocarcinoma. It seems that the some changes or clone selection
have been occurred during the processs. It is just a speculation, but please add
some discussion if possible.
3. FGFR2 amplification could be important in this tumor, but it would be better
to discuss the significance of TP53 mutation as well as the other mutations at
AKT3, NOTCH1.
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