Review for 10.1186/s12876-021-01777-7 (2021)

Reviewer’s report
Title: 
Neuroendocrine carcinoma of the common bile duct associated with
congenital bile duct dilatation: a case report
Version: 
0 
Date: 
21 Mar 2021
Reviewer's report:
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The authors present a well-written work examining the neuroendocrine
carcinoma of the common bile duct associated with congenital bile duct
dilatation: a case report. Limitations of the study indeed exist and are
appropriately recognized, and the preliminary nature of the study is recognized.
1. 
In the abstract, the conclusion is poor. As you already mentioned that this
disease is rare and the etiology is unknown, however the most important finding
in this case should be written in the conclusion section. 
2. Case presentation is subdivided along with the subtitles. It might be better to
be united as a whole paragraph.
3. ERCP is not performed to prevent pancreatitis, please add the POCS and
MRCP data. How do you diagnose this patients without cytology and tumor
biopsy? In this case POCS could be an important tool for detect the tumor spread
and tumor macroscopic findings.
4. 
In discussion section, stem cell would have an essential role in developing the
adenocarcinoma and neuroendocrine carcinoma. Is there any data of stem cell
marker in this case? 
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
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