Review for 10.1186/s12876-020-01499-2 (2020)

Reviewer’s report
Title: 
Long Term Outcomes of Colon Polyps with High Grade Dysplasia Following Endoscopic
Resection
Version: 
0 
Date: 
07 Aug 2020
Reviewer's report:
Jia-Jang Chang et al performed a retrospective study on the longterm outcome of patients with previous
endoscopic resection of high-grade dysplasia polyps. This paper is undoubtedly interesting, but there are
some major issues that should be addressed.
1) In my opinion, the most important issue that should be taken into account when a study on the risk of
recurrence of diseases is performed is the time factor. In your article, this factor was not analyzed. Please,
conduct specific analysis (Cox-models, Kaplan Meier curves,…) to establish the role of interval time
between colonoscopies in the recurrence of polyps 
2) Were all the colonoscopies performed because of screening reasons or in some patients there were
symptoms? In the second case show a subgroup analysis about the risk of recurrence in symptomatic and
asymptomatic patients
3) Why did you choose 3 polyps as the cut-off for your analysis? Did you perform a ROC curve to
establish the number of colon polyps to take as a cut-off? Are there other reasons?
4) In Table 3 show the results with two decimal numbers
5) Page 12 line 7: correct p=0.49 with the exact number resulted from multiple regression
6) As known, the risk of progression for tubular and non-tubular adenomas is pretty different. Please,
comment in discussion the fact that in your analysis the risk of recurrence of adenomas is not dependent
on the histological type
7) Show details about the risk of recurrence according to "morphological" types of adenomas (LST,
pedunculated, sessile,…) 
8) As you correctly underlined in the discussion section, there are already some studies and also meta-
analysis on this topic. Comment which are the peculiarities of your article respect to others.
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Is the study design appropriate to answer the research question (including the use of appropriate controls),
and are the conclusions supported by the evidence presented?
Yes
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Yes
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No
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Yes
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manipulation?
Yes