Review for 10.1186/s12876-021-01997-x (2021)

Reviewer’s report
Title: 
A Case of Primary Intestinal Lymphangiectasia with non-Hodgkin
Lymphoma
Version: 
0 
Date: 
06 May 2021
Reviewer's report:
The manuscript was reviewed for publication in the journal. The manuscript was
written for showing a case of primary intestinal lymphangioectasia (PIL) with
non-Hodgkin lymphoma and a systemic review of the literature on lymphoma
and PIL. It is the reviewer's opinion that the case and review are interesting and
that the manuscript is easy to follow. However, it appears that there are a couple
of issues in the manuscript.
1) Figure 2 C and D showed D-240 staining. The authors did not mention D-240
staining in the manuscript. The authors should explain the point.
2) In the case, the authors did not show the evidence of protein-loosing
gastroenteropathy. How about the related stool exam or scintigraphy? The
authors should explain the pointes.
3) Table 1 showed the clinical characteristics of patients with PIL-associated
lymphoma. PIL appears to be a potent predisposing factor for lymphoma after 10
or more years. However, the time to lymphoma is only 3 years in the present
case. The authors should discuss the differences of characteristics between the
present case and previous cases more carefully.
4) The authors mentioned the immunohistochemical analysis of diffuse large B-
cell lymphoma only in the manuscript. The images should be added in the Figure
3.
5) Figure 1A and 1B showed the contrast-enhanced computed tomograpgy in the
figure legend. It seems to be a plain CT. The authors should explain the issue.
6) Figure 2 and 3C needs bar scales.
7) In Figure 2B and 2D, it is better to show which area is enlarged from Figure
2A and 2C, respectively. The authors should fix the points.
8) Mistakes:
Page 3, line 55: distension
Page 5, line 107: no space between pain and [7].
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
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