Review for 10.1186/s12876-022-02378-8 (2022)

Reviewer’s report
Title: 
Pancreatic Involvement in Erdheim-Chester Disease: A Case Report and
Review of the Literature
Version: 
0 
Date: 
21 Mar 2022
Reviewer's report:
Pancreatic Involvement in Erdheim-Chester Disease: A Case Report and Review
of the Literature Jiawen Dai; Tian-Hua He; Ming-hui Duan; Yue Li; Xin-Xin
Cao BMC Gastroenterology
The authors present a case report of pancreatic Involvement in Erdheim-Chester
patient.
The authors analyzed the pancreatic involvement in others histocytosis types.
I have remarks concerning the data.
PAGE 2, line 54 "The BRAFV600E mutation .... " The general information
about disease are present with only one publication concerning molecular and
IHC data. Others articles should be cited in this sentences and the information
should be complete. 
The polymerase chain reaction only could not be used to
detect BRAF mutation as it's described in this article.
Other IHC markers should be analyzed in all accessible materials. RDD are also
CDa1 negative and S100 positive. 
Other mutations than BRAF p.V600E should be analyzed as they have also be
reported in ECD cases. 
In a pangenomic analysis from 2016 Diamond EL et al.,
all ECD cases had at least 1 mutation activating the MAPK pathway. 
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