Review for 10.1186/s12876-018-0869-9 (2018)

Reviewer’s report
Title: Vanishing Bile Duct Syndrome with Hyperlipidemia after Ibuprofen Therapy in an Adult Patient:
A Case Report
Version: 1 Date: 09 Apr 2018
Reviewer: Shinichi Aishima
Reviewer's report:
The authors reported the vanishing bile duct syndrome (VBDS) probably associated with NSAIDS
(ibuprofen) of adult case. DILI is an uncommon cause of VBDS, but some child cases were reported.
This adult case show persistent jaundice with hyperlipidemia and important clinical information for the
clinicians. This manuscript has a few problems.
1)"Central arteries" is uncommon term for arterioles or arteries in the portal tracts.
2)Close photograph of vanishing bile ducts should be represent in Figure 1.
3)Which cells are positive for CD10, CD38, CK7, CK19…? CD38 and MUM1 are plasmacytic
marker, and CK7 and CK19 are biliary marker. CK7-positive hepatocytes indicates cholestatic
hepatic change and its important finding.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Unable to assess
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an additional 
statistical review?
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.
Not relevant to this manuscript
Quality of written English
Please indicate the quality of language in the manuscript:
Acceptable
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