Review for 10.1186/s12876-020-01583-7 (2021)

Reviewer’s report
Title: 
Effectiveness of introducing a 20-gauge core biopsy needle with a core
trap in EUS-FNA/B for diagnosing pancreatic cancer
Version: 
0 
Date: 
25 Sep 2020
Reviewer's report:
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1. In your study, the patient's number of PC20/PC22 and AC 22 showed big
difference. How to explain the reason about the number and how to overcome
the selection bias and the influence of the study result?
2. What is the definition of stroke length in your study? Why did the stroke
length between PC20/PC22, AC 22 show big difference. How about the
difference n stroke length influence the study?
3. As we know, PC20 has larger diameter and may get more specimen. In your
study, the diagnostic accuracy showed no difference between PC20 and AC22.
Could you explain the reason? Could you show the table about different
parameters like diagnostic accuracy and macroscopic onsite evaluation about the
effectiveness of EUS-FNA/B between PC20 and AC 22 ?
4. As we known, PC22 and AC22 are both FNB needle. How about the
diagnostic accuracy between these two needles? If the diagnostic accuracy is
different, the reason why?
5. Discuss about the effectiveness of PC20 in your study. However, PC20 and
AC22 showed no difference of the overall diagnostic accuracy. As we known,
22-gauge needle may be much easier for tissue sampling, especially for
pancreatic head. Can you analyse about the diagnostic accuracy in different
locations of pancreatic cancer between these two needles?
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
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from apparent manipulation?
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