Review for 10.1186/s12876-020-01319-7 (2020)

Reviewer ’s report  
 
Title: Use of Immunostaining for the Diagnosis of Lymphovascular Invasion in Superficial  
Barrett’s Esophageal Adenocarcinoma  
 
Version: 0 Date: 30 Jan 2020  
 
Reviewer: Matteo Fassan  
 
Reviewer's report:  
 
The evaluation of LVI in early Barrett's adenocarcinoma is a hot topic in gastroesophageal 
oncology . This is an interesting study and results could be of importance for the field. My 
only concern is regarding the evaluation by a single GI pathologist. I would suggest to have 
at least two pathologists  who will independently and jointly assess the entire  series. In fact, 
most national/international guidelines support the evaluation by two different pathologists of 
cases of Barrett's high -grade dysplasia or adenocarcinoma in biopsy/endoscopic material.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls ar e required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
 
 
 
 
 
 
 
Declaration of competing interests  
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