Review for 10.1186/s12876-022-02438-z (2022)

Reviewer’s report
Title: 
Nonsteroidal anti-inflammatory drug exposure and the risk of microscopic colitis
Version: 
1 
Date: 
23 Mar 2022
Reviewer's report:
The authors have analyzed detailed characteristics of microscopic colitis patients who were diagnosed at a
single center in Chicago. They analyzed the risk factors that were associated with diagnosis of MC and
have found that NSAID remained statistically significant after multivariate analysis and subgroup analysis.
The strength includes including a prospective cohort of patients undergoing colonoscopy for diarrhea and
a separate large cohort of established MC patients. Furthermore, medication usage data was accurately
collected by study coordinators, which is a huge advantage compared to insurance claims database or
observational cohort studies. 
Major:
1. Abstract, Results: Included a sentence describing that there were a total of 80 MC pts (21 new and 59
established) and that they were more likely to be older and females compared to controls. If there is word
limitation, the conclusion can be shortened.
2. Table 3: Add the odds ratio. 
3. Table 4: Add the p-values.
4. Introduction and Conclusion: well written and I don't find any issues to address.
Minor:
1. Results, page 8, last paragraph and Table 3, title: Change subtype to subgroup.
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Is the study design appropriate to answer the research question (including the use of appropriate controls),
and are the conclusions supported by the evidence presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free from apparent
manipulation?
Yes