Review for 10.1186/s12876-021-01814-5 (2021)

Reviewer’s report
Title: 
Co-occurrence of Wilson's disease and systemic lupus erythematosus: a
case report and review of literature
Version: 
1 
Date: 
01 Mar 2021
Reviewer's report:
This is an interesting clinical case describing the co-ocurrence of SLE and
Wilson´s. There are some points that should be added to this work in order to
increase the clinical usefulnes for the readers:
1) which was the indication for performing abdominal ultrasound? pain, liver
chemistry/liver function tests abnormalities, presence of ascites? This point is
important to clarify, because a spectrum of abnormalities have been described in
patients with SLE (DOI: 10.1177/0961203320923398) and knowing which
patients should be screened for liver disease, will help to the reader to make
decisions. 
2) even though there is a description of "liver cirrhosis" in the CT scan and
ultrasound, the images are not provided. 
3) Is it difficult to sustain the diagnosis of liver cirrhosis, at least in the images
included in the manuscript. Low levels of albumin could be secondary to activity
of the disease (SLE) or malnutrition, and no other abnormalities were found in
liver chemistry.
4) was there any neurological involvement? both diseases can cause
neuropsychiatric abnormalities.
5) please provide the laboratory values assessing liver function (TB, AST, ALT,
AP, globulins, INR, etc.), as well as the severity scores in case of corroborate the
diagnosis of liver cirrhosis (i.e. Child-Pugh and MELD).
6) please specify the dose of zinc given to the patient. Was there any
improvement in liver function after treatment? this has been described in other
case report (CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
2006;4:1069-1071)
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
No
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Yes
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Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
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