Review for 10.1186/s12876-018-0818-7 (2018)

Reviewer ’s report  
 
Title:  Successful treatment of oral Crohn's Disease by anti -TNF -alpha dose escalation - a case 
report  
 
Version: 1 Date: 16 Jan 2018 
 
Reviewer:  Nanne K  de Boer  
 
Reviewer’s report:  
 
An interesting case description of an relatively unknown manifestation of Crohn's disease. Of 
importance for the clinical readers.  
 
 
Some minor comments:  
 
- Is the word "breaktrough"  correct (medical) English?  
 
- The patient is failing azathioprine and later adalimumab (given the oral manifestation), was the 
strategy of therapeutic drug monitoring applied? And what were the outcomes of the thiopurine 
metabolites, and later the adalimum ab levels (and antibodies)?  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publication of this 
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3. Do you hold or are you currently applying for any patents relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do yo u have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
 
No conflicts  
 
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