Review for 10.1186/s12876-021-01608-9 (2021)

Reviewer’s report
Title: 
Characteristics of hepatic solitary necrotic nodules on contrast-enhanced
ultrasonography
Version: 
1 
Date: 
29 Sep 2020
Reviewer's report:
The paper by Chunyu Lu entitled 'Characteristics of hepatic solitary necrotic
nodules on contrast-enhanced ultrasonography' is a retrospective study that
analyzed which solitarly necrotic nodules (SNN) has the characteristic findings
on the CEUS. The authors described the CEUS enhancement pattern was divided
into 2 types. Type 1 is enhancement in all three phases. Type 2 presence of
peripheral thin rim-like hyper-enhancement in the arterial phase and iso-
enhancement in the portal phase and delayed 
phases. The article will be of
interest to readers of this journal. To take priority for publication, however, the
manuscript should be revised. 
Comments: 
1. Correct diagnosis of SNN is difficult. Which modality is the highest accuracy?
2. Please add the findings of PET/CT for SNN. 
3. Please describe why you procedured the case of figure 1 and 11 patients of no
enhancement. No enhancement is generally no malignant finding.
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