Review for 10.1186/s12876-021-01901-7 (2021)

Reviewer’s report
Title: 
Tri-Modal Management of Primary Small Cell Carcinoma of the Pancreas
(SCCP): a Rare Neuroendocrine Carcinoma (NEC)
Version: 
0 
Date: 
13 May 2021
Reviewer's report:
This manuscript presents an interesting and rare presentation of primary SCCP
demonstrating the benefits of tri-modality therapy resulting in favorable disease-
free survival after more than 18 months. The authors prepared a well-written,
detailed yet concise case summary with relevant clinical milestones, including
the added value of next generation sequencing analysis. They also provided a
literature review relevant to these type of tumors, their management and the
observed outcomes. I do have the following recommendations:
- Please, describe further details about tumor enhancement characteristics,
pancreatic duct dilation and atrophy observed on pre-operative CT.
- Please, provide information on the patient's performance status pre and post
neoadjuvant therapy.
- Please, include surgical details about the previously alluded vascular invasion
(SMV/SMA), especially in the settings of positive microscopical uncinate
margins and subsequent postoperative CT findings.
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