Review for 10.1186/s12876-020-01520-8 (2020)

Reviewer’s report
Title: 
Association between apoptosis inhibitor of macrophage and microsatellite
instability status in colorectal cancer
Version: 
0 
Date: 
02 Sep 2020
Reviewer's report:
The authors revealed that reduced AIM levels are associated with MSI-H
subtyping of CRC. The manuscript will be improved after several revisions.
Major comment:
1. The authors should describe whether this manuscript is prospective study or
not. If so, please present registration number in the text.
2. Table 2. The authors should add morphology of the tumor as
clinocopathological factors.
3. Propensity score matching analysis can be more suitable to reveal the
association between AIM levels and MSI-H.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes