Review for 10.1186/s12876-021-01754-0 (2021)

Reviewer’s report
Title: 
Microbial Diversity Following Antibiotic Treatment of Clostridioides
difficile Infection
Version: 
0 
Date: 
20 Nov 2020
Reviewer's report:
Minor comments:
- A clear and updated definition of CDI should be provided and stated in the
method section.
- The key findings regarding microbiota analysis should be added in the results
of the Abstract.
- Once the CDI is abbreviated, then it should be used in abbreviated form
thereafter in the manuscript. Please correct this throughout the article context.
- Few data is provided for the study patients. The frequency of defecations,
underlying disease if any, such as IBD and hospitalization should be clearly
added and discussed. These factors can affect the gut microbiome of the patients.
- The F/B ratio should be determined in microbiota analysis and presented as a
graph.
- How about the Akkermansia muciniphila? these bacteria are controversial in
the gut of CDI patients. The authors should focus on this species and discuss it in
the manuscript and compare with previous reports in the literature.
- A minor proofreading is required before publication.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
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Yes
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Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes