Review for 10.1186/s12876-017-0643-4 (2017)

Reviewer ’s report  
 
Title: Abnormal ileal stem -, neurogenin3 - and enteroendocrine -cells in patients with irritable 
bowel syndrome  
 
Version: 0 Date: 29 Mar 2017  
 
Reviewer: Bodil Ohlsson  
 
Reviewer's report:  
 
BMGE -17-00006  
Abnormal ileal stem, neurogen3 - and enteroendocrine -cells in patients with irritable bowel 
syndrome  
This is an interesting topic and the study is well performed. I have some comments.  
1. Overall, there are some spelling errors and grammatical errors which  need to be corrected, 
especially in the result section. Please read and check the language carefully.  
 
2. In the discussion, I miss a discussion about whether the changes are primary or secondary to 
IBS. Are the down -regulated peptide levels the primary ca usal event?  
 
3. In result section, page 6; what is Kruskal -Wallis Anova test? What is the difference from a 
common Kruskal -Wallis test or Dunn´s test? There is no explanation to Kruskal -Wallis 
Anova test in the statistical analyses.  
 
4. Please add the statis tical methods in all tables and legends, so they are clearer to read.  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, plea se specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscrip t or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following question s: 
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or sha res in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you re ceived reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interes ts in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare I have no competing interests  
 
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on my report to the authors and, if the manuscript is accepted for publication, my named report  
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I agree to the open peer review policy of the journal