Review for 10.1186/s12876-016-0552-y (2016)

Reviewer ’s report  
 
Title:  Liver Abscess and Bac teremia Caused by Lactobacillus: Role of Probiotics? Case Report 
and Review of the Literature  
 
Version: 0 Date: 25 Dec 2015 
 
Reviewer:  Conrado M  Fernandez Rodriguez  
 
Reviewer’s report:  
 
This is an inter esting case report describing a female patient suffering a liver pyogenic abscess 
by lactobacilus sp. There are few reports of serious infection produced by this microorganism 
commonly used as a probiotic in a variety of conditions. In adition to age, this  elderly patient had 
several factors of inmmunodepression (DM -2 and ESRD). I would like the authors to further 
clarify some minor points.  
 
1. Did they have the opportunity of culturing the source of probiotics in order to verify that was 
the same microorga nism (Eg the same antibiotic sensitivity prophile). Was the bacteria resistant 
to metronidazole that the patient was receiving for her C. difficile infection?  
 
2. Table 1 should be edited for easier reading.  
  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publication of this 
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3. Do you hold or are you currently applying for any patents relating to the content of the 
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4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
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below. If your reply is yes to any, please give details below.  
 
I have nothing to disclose regarding this manuscript  
 
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to the editors, which will not be published . 
 
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