Review for 10.1186/s12876-021-01948-6 (2021)

Reviewer’s report
Title: 
Development of pulmonary sarcoidosis in Crohn’s disease patient under
infliximab biosimilar treatment after long-term original infliximab treatment: A
case report and literature review.
Version: 
0 
Date: 
08 Aug 2021
Reviewer's report:
This is a well written and well referenced report on the occurrence of sarcoidosis
in a patient with Crohns disease receiving anti TNF therapy.
It is however, difficult to reconcile with the conclusion that bio similars can be
mechanistically implicated.Is this not a class effect and perhaps a coincidence
that the patient was recently switched?
A short description of the possibility of this being a class 
effect should be
considered.
A short description of why the ACE levels were normal and why steroids were
not felt necessary would be helpful even if in a few lines.
This 
occurrence was perhaps unavoidable but the authors could use this
opportunity to educate readers on considerations with withdrawing anti TNF
therapy in patients in long-term remission given the possibility of drug related
complications in particular and in this instance sarcoidosis particularly.
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