Review for 10.1186/s12876-019-1038-5 (2019)

Reviewer ’s report  
 
Title: Anemia following zinc treatment for  Wilson's disease:a case report and literature review  
 
Version: 0 Date: 01 Feb 2019  
 
Reviewer: Peter Heder a 
 
Reviewer's report:  
 
This is a straightforward case report of anemia due to iatrogenic copper deficiency. This is a 
known problem but given the delayed recognition of the cause of her anemia, it still may be 
useful to report this problem.  
 
The close monitoring of copper and zinc is recommended in WD patients on zinc and I do not 
see any numbers to see the dynamics of urine copper levels. There are two values of plasma 
copper in a very deficient range. I would like to see the serial 24 -H urin e copper and zinc values 
to see the changes in her WD control and later in induction of her copper deficiency.  
I would also like to see more data justifying this high copper dose (24 mg daily using zinc 
gluconate).      
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in t he manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of wr itten English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
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