Review for 10.1186/s12876-021-01715-7 (2021)

Reviewer’s report
Title: 
Very-Low-Dose Aspirin and Surveillance Colonoscopy is Cost-effective
in Secondary Prevention of Colorectal Cancer in Individuals with Advanced
Adenomas: Network Meta-analysis and Cost-effectiveness Analysis
Version: 
0 
Date: 
22 Jan 2021
Reviewer's report:
The study wanted to prove several points in the field of colorectal cancer (CRC)
prevention. The first part is network meta-analysis of chemo-preventive agents
(CPA) for 2nd prevention of CRC. The second part is cost effective-analysis for
CPA and surveillance interval. 
1. The meta-analysis did not address the process of literature reviews, quality of
the trial included, and the outcome parameters clears. The results were very hard
to interpret.
2. CEA process was also not clear. We did not know how the evidence of CPA
from the meta-analysis for advanced adenoma had the effect on cost.
3. I suggest to solve one hypothesis in one manuscript. 
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
No
Are the methods sufficiently described to allow the study to be repeated?
No
Is the use of statistics and treatment of uncertainties appropriate?
No
Is the presentation of the work clear?
No
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
No