Review for 10.1186/s12876-021-02086-9 (2022)

Reviewer’s report
Title: 
Strategies for discontinuation of proton pump inhibitors (PPIs) in patients
with long-term PPI administration: a randomized controlled trial
Version: 
0 
Date: 
23 Jun 2021
Reviewer: 
Sanne Rasmussen
Reviewer's report:
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Thank you for the opportunity to review this well-written protocol for an
important study.
I only have a few minor questions/suggestions: 
Page 6, line 45: Should the 'even though' be 'if' instead. That would make more
sense.
Page 9, line 10-13: The patient had symptoms before starting PPI. How was that
assessed? 
Page 12: Why was the patients asked to fill in HADS?
Page 12, line 30-33: Is it a structured diary that is handed out to the patients or
should they just write something down themselves?
Page 12, line 51-57: Would it not be preferable to have a baseline evaluation of
the symptoms for the patients to assess whether the symptoms become worse
after discontinuation?
Page 15, line 22-29: How will the adverse events be evaluated? By diary or
interview/examination by and MD? 
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