Review for 10.1186/s12876-019-0947-7 (2019)

Reviewer ’s report  
 
Title:  Autoantibody Detection is Not Recommende d for Chronic Pancreatitis: A Cross -sectional 
Study of 557 Patients  
 
Version: 0 Date: 28 Oct 2018 
 
Reviewer:  Bipadabhanjan  Mallick  
 
Reviewer’s report:  
 
MAJOR  
 
1. Why this auto antibody was done in these patients as diagnosis of chronic pancreatitis is 
imaging based. If it was done suspecting AIP then what are the frequency of auto 
antibody most frequently seen in AIP patients like ANA, rheumatoid factor, anti 
lactoferrin, anti carbonic anhydrase ?  
 
2. Four antibody are less frequently associated with study group compared to healthy 
control, are they protective against development of CP ? No mention in discussion  
 
3. Uniformity of detection of antibody is not there like some by ELISA and some by IIF?  
 
4. When there is definite diagnosis of etiology of CP, why these antibody were done in 
alcohol etiology of CP. Is it done for prognostication, no mention in discussion.  
 
5. Discussion should be focused association of auto antibody with CP. No need of discussing 
about antibody or its association with other etiologies.  
 
6. What is the explanation for DM in first/second/third degree relatives as protective factor 
for beta 2 -GPI and DM, CBD stricture as risk?  
 
 
MINOR  
 
1. Few spelli ng mistakes need to be corrected  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
No 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
No 
 
Are you able to assess any statistics in the manuscript or would yo u recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
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