Review for 10.1186/s12876-023-02695-6 (2023)

Reviewer’s report
Title: 
Potential utility of a multi-component coagulation factor panel to calculate
MELD scores and assess the risk of portal vein thrombosis in chronic liver
disease
Version: 
1 
Date: 
12 Jan 2023
Reviewer's report:
In this manuscript, the authors hope to evaluate the severity of CLD with
specific coagulation factors and predict the occurrence of PVT. However, the
article lacks innovation and the overall workload is small.
Major comments
1. The expression trend of related coagulation factors in CLD has been reported,
and in the manuscript, the author constructed a new MELD scoring standard
based based on related similar studies.
2. In the manuscript, the author established an equation to predict the occurrence
of PVT based on FVIII, FV and PS, but the sample size of PVT was only 3
cases, which could not explain its predictive value.
3. The sample size is smallso it is recommended to carry out the verification of
multi-center large sample.
4. 
Since the new MELD scoring system is not superior to the original scoring
system in the ROC curve of half a year and one year, what are the advantages
and clinical application value of the new scoring system? 
5. The change trends of sP-selectin and asTF in the two cohorts were different
and inconsistent with those reported in the literature. The authors did not explain
the reason for this phenomenon.
6. The follow-up information of the cohort and the supplementary methods of
PVT diagnosis were complete.
Declaration of competing interests
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paper?
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
No
Are the methods sufficiently described to allow the study to be repeated?
No
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes
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No