Review for 10.1186/s12876-018-0868-x (2018)

Reviewer’s report
Title:  Vedolizumab  use  after  failure  of  TNF- α  antagonists  in  children  and  adolescents  with
inflammatory bowel disease
Version: 0 Date: 07 Jun 2018
Reviewer: Amit Assa
Reviewer's report:
In general, there are only few reports on tretment with vedolizumab in pediatric patients. Nevertheless,
there is sufficient retrospective data from larger cohorts so this paper does not add significant data to
the existing data.
Major comments:
1. Only few patients from each disease type reported.
2. Were there patients treated with 2 or more biologic agents prior to vedo?
3. There is no such thing as partial remission. Should be changed to partial response.
4. Fecal calprotectin data would be beneficial.
5. Knowledge of the type of loss of response to anti TNF is crucial in order to understand the
mechanism of vedo response (immunogenic, pharmacokinetic, pharmacodynamic) so anti-TNF
levels at the time of TNF failure should be reported.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Unable to assess
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
No
Are you able to assess any statistics in the manuscript or would you recommend an additional 
statistical review?
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Acceptable
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