Review for 10.1186/s12876-020-01250-x (2020)

Reviewer’s report
Title: Association Analysis between SNPs in LATS1 and LATS2 and Non-Cardia Gastric Cancer
Version: 1 Date: 03 Feb 2020
Reviewer: Hyo-Joon Yang
Reviewer's report:
Comments to the Author:
Major comment
1. Results and Table 1.
Please report Anti-H. pylori seropositivity in patients with gastric cancer in the Results and Table 1. 
2. Results and Table 4.
Although the authors conducted the analysis in the Table 4 with adjustment of age and sex, these results
should also adjusted for Anti-H. pylori seropositivity. Please present revised results.
Minor comments
3. Abstract
"H. pylori infection was determined …" -&gt; "H. pylori infection was determined by serological test
using …"
4. Abstract "Finally, appropriate statistical …" 
Please don't use the term "appropriate". Instead, please describe specifically.
5. Introduction
"Studies have reported that the expression levels of LATS1 and LATS2 proteins in malignant tumor
cells …"
Please revise the term "malignant tumor" to describe specific cancer types.
6. Results
The authors described that there were 427 patients in the control group including 202 patients with
Anti-H. pylori seropositive. However, there were only 425 patients in the control group and 200
patients with Anti-H. pylori seropositive in the Table 3 and Table 4. Please explain this discrepancy.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an additional
statistical review?
If  an  additional  statistical  review  is  recommended,  please  specify  what  aspects  require  further
assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Acceptable
Declaration of competing interests
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