Review for 10.1186/s12876-020-01467-w (2020)

Reviewer’ s report
Title: Carbon tetrachloride (CCl4) accelerated development of non-alcoholic fatty liver disease
(NAFLD)/steatohepatitis (NASH) in MS-NASH mice fed western diet supplemented with fructose(WDF)
Version: 1Date: 22 Sep 2020
Reviewer's report:
This manuscript has been reported about the new mouse model for non-alcoholic fatty liver
disease (NAFLD)/steatohepatitis (NASH). The authors showed that the effect of administration ofcarbon tetrachloride (CCl4) can make accelerated liver fibrosis.This new mouse model is very important for the research of NAFLD. The authors have proofreadeverything clearly. I believe that it is good enough to accept this manuscript for publication inBMC Gastroenterology.
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YesDeclaration of competing interests
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(default)
Is the study design appropriate to answer the research question (including the use of appropriate
controls), and are the conclusions supported by the evidence presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?YesIs the use of statistics and treatment of uncertainties appropriate?YesIs the presentation of the work clear?YesAre the images in this manuscript (including electrophoretic gels and blots) free from apparent
manipulation?
Yes