Review for 10.1186/s12876-022-02417-4 (2022)

Reviewer’s report
Title: 
Epstein-Barr virus-associated gastric adenosquamous carcinoma with
concurrent gastric carcinoma with lymphoid stroma: A case report and review of
the literature
Version: 
1 
Date: 
16 May 2022
Reviewer's report:
Undifferentiated adenocarcinoma presents a similar histology, thus you must
show clear squamous differentiation. There is insufficient evidence that this case
is an adenosquamous carcinoma. HE stain unable to distinguish between
adenocarcinoma and squamous cell carcinoma due to poor photographic
resolution. It is difficult to evaluate.
Other molecular markers such as cytokeratins (CK1/5/10/14) should be
confirmed.
Could you check for expression of EBV latent genes including LMP1?
Is it possible that the two cancers coincided?
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
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