Review for 10.1186/s12876-021-01885-4 (2021)

Reviewer’s report
Title: 
Study protocol P-MAPS: Microbiome As Predictor of Severity in Acute
Pancreatitis: A prospective multicentre translational study
Version: 
0 
Date: 
09 Apr 2021
Reviewer's report:
This is a very interesting project, preliminary literature data indicate microbiota
disorders in pancreatic diseases, in acute pancreatitis, a significant role of
bacterial translocation in the pathogenesis of pancreatic necrosis infection has
been shown for years. To date, the prediction of ozt severity is an open problem.
It seems to me, however, that the authors should certainly specify the inclusion
criteria, which are too general and will certainly make the analysis of the study
difficult. It seems advisable to introduce into the inclusion criteria information
on the use of probiotics recently before the disease (this is now common OTC
practice), as well as the possible use of antibiotics for many different reasons at a
certain time before the onset of inflammation
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