Review for 10.1186/s12876-022-02578-2 (2022)

Reviewer’s report
Title: 
Multimorbidity among Inflammatory Bowel Disease Patients in a Tertiary
Care Center: A Retrospective Study
Version: 
2 
Date: 
22 Jun 2022
Reviewer: 
Shahram Agah
Reviewer's report:
This is an interesting take on the prevalence of multimorbidity in IBD patients;
however, the lack of non-IBD controls limits the possible interpretations and
conclusions. Comments:
1. As I gathered from the manuscript, multimorbidity was defined as at least two
concomitant diseases aside from IBD. Please ensure that the definition is
apparent in the abstract and the results section.
2. In Page 7, line 117, it is mentioned that the median age of patients is 22 years.
Please also add the median age to Table 1.
3. It would be better if you could add the definition of type 1 and 2 arthritis for
Table 2.
4. One of the essential results of the study is that 4.9% of IBD patients without
comorbidities have DM. However, I could not find the corresponding data in the
Tables. 
5. The statistical analysis could be improved. I can propose using adjusted
logistic regression model to demonstrate the association level between
multimorbidity in IBD and different variables, including the type of IBD, gender,
thrombosis, etc. 
6. There are minor spelling and grammar errors in the manuscript that should be
noted.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
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Yes
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from apparent manipulation?
Yes