Review for 10.1186/s12876-020-01416-7 (2020)

Reviewer’ s report
Title: Eosinophilic Gastroenteritis as a Cause of Non-Helicobacter pylori, Non-gastrotoxic Drug
Ulcers in Children
Version: 0Date: 21 May 2020
Reviewer's report:
This study investigated the cause of peptic ulcers in children, and found non-H. pylori, non-
NSAIDs (idiopathic) ulcers account for the majority of the cause. Especially, they found thateosinophilic gastroenteritis accounted for substantial portion of causes of peptic ulcer in children.Although there have a large number of studies from various geographic areas on the prevalence ofidiopathic peptic ulcers in adult population, such reports among children are scarce at the moment.Hence, this study is valuable. I have following points to be revised.
Major
1.In retrospective study, the prevalence of idiopathic peptic ulcers tends to be overestimated (seeWorld J Gastroenterol 2014 Jan 21;20(3):706-13). Although the authors mentioned it shortly as alimitation, they need to address this issue in more details.2.Although the authors analyzed the rate of each cause of peptic ulcers. I would like the authors tomake some comments on the actual number of patients. Does the number of idiopathic ulcerincrease absolutely, or just relatively.3.I am interested in ulcer location (e. g. gastric vs. duodenal). Please discuss the issue referring tothe cases in adult patients (e. g. Scand J Gastroenterol. 2016 Jul;51(7):782-7).
Minor
The authors need to clearly state how gastrotoxic drugs are define in this analysis (kinds and
duration). E. g. is the drug usage defined by the usage at the diagnosis alone, or is usage severalweeks before the diagnosis also included?
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
YesDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statisticsQuality of written English
Please indicate the quality of language in the manuscript:
Acceptable
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?
6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interestsReviewer Publication Consent. I agree for my report to be made available under an Open Access
Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manu-script is accepted for publication. Any comments that I do not wish to be included in the publishedreport have been included as confidential comments to the editor, which will not be published.Ifyou are not happy for us to publish this report, please contact the editorial office before completingthe review.If you wish, you can include your name in your published report. Please note you mustdecide whether to include your name at the start of the process and confirm this decision wheneverprompted. If you change your decision later, we will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report.
(default)