Review for 10.1186/s12876-019-1082-1 (2019)

Reviewer’s report
Title: VWF/ADAMTS13 ratio as a potential biomarker for early detection of hepatocellular carcinoma
Version: 0 Date: 12 Dec 2018
Reviewer: Theodoros Androutsakos
Reviewer's report:
Overall a good effort. I was wondering if you could follow up the patients and see if any of the patients
receiving RF treatment had PV thombosis in the next 4 months after diagnosis and correlate that with
VWF/ADAMTS13 ratio ,as well as if tumour progression was correlated with that ratio. Of course
having more patients would be a plus, as well as making your study retrospective, see if a higher ratio
at baseline can reveal which patients are going to have HCC in the future. However since this is not the
aim of this study I feel your study is worthy of publication.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?
If an additional statistical review is recommended, please specify what aspects require further
assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Acceptable
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