Review for 10.1186/s12876-023-02684-9 (2023)

Reviewer’s report
Title: 
The role of high serum triglyceride levels on pancreatic necrosis
development and related complications
Version: 
0 
Date: 
21 Dec 2022
Reviewer: 
Omar Ait Sahel
Reviewer's report:
Thought the present paper the authors point out 
the impact of high serum
triglyceride levels on the pancreatic necrosis development. The work
methodology followed by the authors is rigorous and consistent and the
evaluated data are provided with high confidence. However, I have some
suggestions for changes and some questions that I would like to highlight
concerning your manuscript for better improvement.
1. Could the authors justify the establish relationship between high triglyceride
level and acute pancreatitis based on endocrine biochemical signals.
2. 
With assumption that the collected data refers to patient that have already
vaccinated against Covid 19, I should draw the attention to authors that a recent
study (ref 1) 
has shown a strong relationship between Covid 19 vaccination and
the development of an acute pancreatitis whereas a second one (ref 2) has shown
also that Covid 19 may elevate the triglyceride level equally.
ref 1: 
Ozaka, Sotaro MDa,
∗
; Kodera, Takamoto MDb; Ariki, Shimpei MDa;
Kobayashi, Takashi MD, PhDc; Murakami, Kazunari MD, PhDa. Acute
pancreatitis soon after COVID-19 vaccination: A case report. Medicine 101(2):p
e28471, January 14, 2022. | DOI: 10.1097/MD.0000000000028471 
ref2: Brian Cheung, Jay Hwang, Ania Stolarczyk, Elliot Mahlof, Robert Block,
Case Study of Hypertriglyceridemia from COVID-19 Pfizer-BioNTech
Vaccination in a Patient with Familial Hypercholesteremia, Journal of Clinical
Lipidology, Volume 16, Issue 1, Supplement,
2022, Pages e13-e14, ISSN 1933-2874,
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
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Yes
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Yes
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