JerMa88/BMC_Gastroenterology_Peer_Reviews huggingface dataset:
Review for 10.1186/s12876-024-03549-5 (2024)

Title: Long-Term Outcomes of S-1 and Oxaliplatin Neoadjuvant Chemotherapy with Total
Mesorectal Excision and Lateral Lymph Node Dissection for Rectal Cancer
Version: 3 Date: 20 Jun 2024
Reviewer's report:
It is my pleasure to be invited to review this manuscript. The multiple treatment modalities
and the various sequence of treatments in the current literature means the ideal management
of rectal cancer is still debated. This paper covers another facet of treatment, the lateral lymph
node dissection, that has divided opinion. Further to that, the centre utilises a “sandwich”
chemotherapy regime. I have a few comments:
1. The study mentioned that this study was conducted in 4 centres, and that this study only
discusses the outcomes of a singular centre. Is there a reason for this?
2. The study aimed to include only stage 2/3 patients. Is this based on MRI staging? The pre-
operative stage distribution may be include in the paper.
3. Since the number of patients with recurrence is small, a more in-depth discussion could
be done specific to these cases, describing pre-treatment and post-treatment MRI changes,
subsequent pathological response, resection margin status etc.
4. Due to the small sample size, the risk factors for local recurrence would be difficult to interpret.
The positive factors, including advanced stage, mucinous sub-type and non-R0 resections are
already known risk factors for higher recurrence. Furthermore, other factors including tumour
size and non-sphincter sparing procedures may likely reach statistical significance with a larger
sample size.
5. If the reported outcomes are at 3 years, the graphs provided are drawn up to 5 years. This
could potentially be misleading.
6. It will be good to discuss the types of complications encountered with a LLND in all patients
included in the study. A table of complications, including operative time, conversion rate,
operative blood loss, re-operations, leak rates etc, should be added.
7. The conclusion in the abstract may not be overly certain of this treatment regimen, given that
it is a prospective cohort study with small numbers. The conclusion in the main paper seems
more balanced, although it is not appropriate to conclude that “preoperative chemotherapy and
TME with LLND are sufficient to control local recurrence”.
Review for 10.1186/s12876-024-03549-5 (2024)

Title: Long-Term Outcomes of S-1 and Oxaliplatin Neoadjuvant Chemotherapy with Total
Mesorectal Excision and Lateral Lymph Node Dissection for Rectal Cancer
Version: 3 Date: 01 Jul 2024
Reviewer's report:
This is an interesting topic concerning lateral lymph node. However, there are several issues
with this article. Firstly, the inclusion criteria do not specify the definition of enlarged lymph
nodes. The indication for lateral lymph node dissection (LLND) is unclear. Increasing evidence
suggests that LLND should be performed when there is suspicion of lateral lymph node
metastasis. It's unclear why the authors routinely perform bilateral lymph node dissection. It
appears that prophylactic LLND is still being performed by the authors. However, substantial
evidence refutes the value of prophylactic LLND in patients without confirmed lateral lymph
node metastasis (J Gastrointest Surg. 2024 Apr;28(4):548-558; Colorectal Dis. 2023;10.1111;
BMC Surg. 2021 May 26;21(1):261.). Even in Japan, the proportion of prophylactic LLND is
decreasing annually (Dis Colon Rectum. 2019 Jun;62(6):e29.). Chinese guidelines explicitly
state that routine prophylactic LLND is not recommended for patients who do not meet
clinical diagnostic criteria for lateral metastasis (Zhonghua Wei Chang Wai Ke Za Zhi. 2024
Jan 25;27(1):1-14.). This study is single-arm and does not compare results with traditional
chemoradiotherapy. Therefore, the study's conclusion that preoperative chemotherapy with total
mesorectal excision (TME) and LLND is beneficial for avoiding radiation-related adverse events
and improving prognosis in rectal cancer lacks rigor. Both the Japanese JCOG1310 study and
Chinese FORWARC study demonstrate that without combined radiotherapy, chemotherapy
alone struggles to control local lateral recurrence (Jpn J Clin Oncol. 2017 Jan;47(1):84-87; Dis
Colon Rectum. 2021 Nov 1;64(11):1321-1330.).
Review for 10.1186/s12876-024-03549-5 (2024)

Title: Long-Term Outcomes of S-1 and Oxaliplatin Neoadjuvant Chemotherapy with Total
Mesorectal Excision and Lateral Lymph Node Dissection for Rectal Cancer
Version: 7 Date: 21 Oct 2024
Reviewer's report:
Noted the reviewers edits based on my comments. I have no additional comments.
Review for 10.1186/s12876-024-03545-9 (2024)

Title: Exploring the association between life’s essential 8 and gallstone disease in the US adult
population: a population-based study utilizing NHANES data from 2017-2018
Version: 4 Date: 15 Sep 2024
Reviewer's report:
Dear Authors,
Your manuscript presents a valuable exploration of the relationship between Life's Essential
8 and gallstone disease. I have provided several suggestions to improve the clarity and depth
of your analysis, particularly regarding the rationale for certain LE8 components, statistical
methods, and implications for public health. Please refer to the detailed comments for specific
points that need further clarification or elaboration.
I look forward to your revisions.
Review for 10.1186/s12876-024-03545-9 (2024)

Title: Exploring the association between life’s essential 8 and gallstone disease in the US adult
population: a population-based study utilizing NHANES data from 2017-2018
Version: 4 Date: 28 Oct 2024
Reviewer's report:
Recommendations for the authors:
1. Why both Chi-square and Fisher's test? the latter is used only for small samples with an
expected frequency less than 5.
2. Why did the authors did not consider taking NAFLD as a covariate?
3.  Glucose levels can be normal if there is insulin resistance and hyperinsulinemia in obese
individuals.
4. Also HS-CRP could be a potential covariate.
5. Instead of Cardiovascular disease and hypertension, indicators like vascular rigidity and
endothelial dysfunction would have been more promising.
6. I think this score has very low power of prediction. The authors should elaborate a new one
or adjust the present one.
7. Why the authors chose the  lowest tertial as a reference group?  How were the cut-points
established?
Review for 10.1186/s12876-024-03545-9 (2024)

Title: Exploring the association between life’s essential 8 and gallstone disease in the US adult
population: a population-based study utilizing NHANES data from 2017-2018
Version: 5 Date: 25 Nov 2024
Reviewer:  Amira A A Othman
Reviewer's report:
I want to extend my congratulations to all those involved in this work. All the required
amendments have already been made carefully and satisfactorily. I hope that the research will
be presented to science.
Review for 10.1186/s12876-024-03551-x (2024)

Title:  Evaluating the relationship between dietary flavonoids intake and Constipation Incidence
in the General US Population
Version: 1 Date: 06 Oct 2024
Reviewer:  Maryam Zare
Reviewer's report:
Dear Editor:
Thanks for the review sent to me.
My review comments are as follows:
I. Footnote of Tables including the applied analysis should be written.
II. Cut-point Quartiles of flavonoids should be determined in Tables.
III. In line 95, the word 'wtdr1d' is unclear and should be corrected.
IV. Reference of the depression questionnaire should be added.
V.  Daily dietary fiber, fluid intake, and physical activity need to be adjusted.
VI. which food groups have Flavonoids? I think you can bring it in the form of a table in the
supplementary file.
VII. The results cannot be generalized due to 24-hour recall. Because this questionnaire cannot
show the seasonal and episodic intakes. The results of the discussion should be interpreted with
more caution.
VIII. Flavonoids are in 7 categories. Based on structural differences, flavonoids are generally
classified into seven subclasses: flavonols, flavones, isoflavones, anthocyanidins, flavanones,
flavanols, and chalcones[1]. In the manuscript write about 6 categories.
IX. STROBE checklist for cross-sectional studies should be added.
X. What questionnaire is used to determine constipation?  In some previous studies, ROME III
criteria have been used[2].
XI. According to the study that was given in the introduction about selenium and magnesium, I
think it is necessary to report the consumption of selenium and magnesium in your results and
discussion section.
XII. In line 72, the relationship should be rechecked.
XIII. Lines 74 to 76 are not clear.
XIV. In line 86, BMQ or BHQ?
XV. Reference PHQ should be added.
XVI. The relationship between the consumption of flavonoids and constipation in men is not
explained in the discussion section. The reasons should be explained in the discussion section.
XVII. In Table 2, Quartile 2 should be rechecked and corrected.
XVIII. In Figure 1, Why constipation has increased despite the increase in consumption of
flavonoids (which possibly has been accompanied by an increase in flavonoid flavonoid-rich
foods)?
1. Shen N, Wang T, Gan Q, Liu S, Wang L, Jin B. Plant flavonoids: Classification, distribution,
biosynthesis, and antioxidant activity. Food chemistry. 2022;383:132531.
2. Salek N, Dadkhah A, Saneei P, Hassanzadeh-Keshteli A, Esmaillzadeh A, Adibi P. The
association between obesity, constipation, and functional constipation in Iranian adults. 2016.
Review for 10.1186/s12876-024-03551-x (2024)

Title:  Evaluating the relationship between dietary flavonoids intake and Constipation Incidence
in the General US Population
Version: 1 Date: 07 Oct 2024
Reviewer:  Luca Massaro
Reviewer's report:
Jiang et al report an interesting landscape on the relationship between dietary flavonoid intake
and constipation incidence in the US population, using NHANES data from 2007-2010. The
authors found an inverse relationship between flavonoid intake, particularly anthocyanidins,
flavanones, flavones, and flavonols, and constipation. The paper concludes that increased intake
of flavonoids could potentially reduce constipation risk.
The paper show a clear and streamlined structure with strong methods and clear objective.
However as some streamlining of the introduction, which is sometimes slightly repetitive and
wordy, may be advised, the main concern I have about this study is the choice of the covariates.
Fiber intake, whether it be soluble or insoluble, can be addressed as one of the primary nutritional
influences on constipation and stool quality. However this seems to be overlooked, even thought
the source of flavonoids from plant-based (and fiber rich) food is highlighted in the text.  I
strongly advise the authors to take into consideration fiber intake in the subject diets and verify
if fiber intake is indeed relevant and if the correlation between flavonoids and constipation is
independent from fiber intake
Review for 10.1186/s12876-024-03551-x (2024)

Title:  Evaluating the relationship between dietary flavonoids intake and Constipation Incidence
in the General US Population
Version: 1 Date: 08 Oct 2024
Reviewer's report:
The study is interesting however, I have some doubts in methodology.
It is well-known that vegetables and fruits have high fiber and fiber is essential for the healthy
digestive system. Therefore, I would like to ask why authors did not incluide fiber intakes or
wht not adjust the energy and fiber or vegetable and fruit intakes to understand whether the
polyphenols directly linked consumption or not. I suggest to authors further analysis to better
results.
Review for 10.1186/s12876-024-03551-x (2024)

Title:  Evaluating the relationship between dietary flavonoids intake and Constipation Incidence
in the General US Population
Version: 2 Date: 20 Nov 2024
Reviewer:  Luca Massaro
Reviewer's report:
I thank the authors for accepting and implementing the additional analyses on fiber intake I
requested, and for a general streamline of the paper.
After the modifications I don't find any problems with the results. However there are still some
minor modifications I'd like you to implement, if the authors agree:
line 178
"Despite the p-trend for flavan-3-ols being 0.06, which is only marginally above the
conventional significance level of 0.05" I think that the "marginally above" argumentation
should not be made and should be removed.
line 233
"flavonoids as well as all flavonoids subclasses intake exhibited a significantly decreased risk
of constipation"  which is then corrected for the identified confounding factors.  I think this
sentence is misleading and should be removed.
Review for 10.1186/s12876-024-03551-x (2024)

Title:  Evaluating the relationship between dietary flavonoids intake and Constipation Incidence
in the General US Population
Version: 3 Date: 26 Nov 2024
Reviewer:  Luca Massaro
Reviewer's report:
I thank the authors for taking into consideration my observations, and I wish to add no further
Review for 10.1186/s12876-024-03553-9 (2024)

Title: Association between ZJU index and gallstones in US adult: a cross-sectional study of
NHANES 2017–2020
Version: 0 Date: 12 Nov 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Abstract Co-variated evaluated could be mentioned Methods Abbreviations should be explained
on their first appearance in the text Parameters included should be described Statistics Power of
the study calculation should be provided
Review for 10.1186/s12876-024-03553-9 (2024)

Title: Association between ZJU index and gallstones in US adult: a cross-sectional study of
NHANES 2017–2020
Version: 0 Date: 24 Nov 2024
Reviewer:  Mohamed H. Zidan
Reviewer's report:
Dear Authors,
Re:Correlation between ZJU Index and Gallstones: An Analysis on National Health and
Nutrition
I find your manuscript well designed and interesting, however, i hopr to address some minor
corrections.
In the introduction elaborate more on the hazards and lifestyle changes encountered by
developing gallstones such as the risk of BIle duct injuries etc.
Use these references for elaboration:
[1] de’Angelis, N., Catena, F., Memeo, R. et al. 2020 WSES guidelines for the detection and
management of bile duct injury during cholecystectomy. World J Emerg Surg 16, 30 (2021).
https://doi.org/10.1186/s13017-021-00369-w
[2]  Zidan, M.H.ED., Seif-Eldeen, M., Ghazal, A.A. et al. Post-cholecystectomy bile duct
injuries: a retrospective cohort study. BMC Surg 24, 8 (2024). https://doi.org/10.1186/
s12893-023-02301-2
In methodology, please elaborate more on the Definition of ZJU index and when were the
samples taken.
The analysis was perfectly chosen and the discussion is clear and sufficient
Thank you
Review for 10.1186/s12876-024-03553-9 (2024)

Title: Association between ZJU index and gallstones in US adult: a cross-sectional study of
NHANES 2017–2020
Version: 0 Date: 24 Nov 2024
Reviewer's report:
I think this is a very interesting paper that examines the correlation between the ZJU index and
the risk of developing gallstones. I have one question. The results showed that people without
gallstones had higher energy and fat intakes than those with gallstones. I think that the health
education intervention mentioned in the conclusion generally refers to dietary guidance and
exercise, but considering the results, doesn't dietary guidance lead to an increase in total calories
and fat intake? I thought that this sentence should not be included because it would cause a
contradiction.
Review for 10.1186/s12876-024-03553-9 (2024)

Title: Association between ZJU index and gallstones in US adult: a cross-sectional study of
NHANES 2017–2020
Version: 1 Date: 29 Nov 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Methods Numerical values describing the study population should be moved in the results Power
of the study calculation should be moved from the results in statistics After those minor changes
the study could be accepted for publication
Review for 10.1186/s12876-024-03553-9 (2024)

Title: Association between ZJU index and gallstones in US adult: a cross-sectional study of
NHANES 2017–2020
Version: 1 Date: 29 Nov 2024
Reviewer:  Amira A A Othman
Reviewer's report:
I want to extend my congratulations to all those involved in this work. All the required
amendments have already been made carefully and satisfactorily. I hope that the research will
be presented to science.
Review for 10.1186/s12876-024-03553-9 (2024)

Title: Association between ZJU index and gallstones in US adult: a cross-sectional study of
NHANES 2017–2020
Version: 1 Date: 30 Nov 2024
Reviewer:  Mohamed H. Zidan
Reviewer's report:
All my comments have been answered. Goodluck
Review for 10.1186/s12876-024-03567-3 (2024)

Title: Risk factors for gastric mucosa lesion in critically ill patients undergoing endoscopy for
percutaneous gastrostomy: a case-control study
Version: 1 Date: 22 Sep 2024
Reviewer's report:
1. There is little relation of PEG implantation to gastric mucosal damage investigated in this
study. It only provides an opportunity to examine the gastric mucosa by endoscope.
2. Besides high dose PPI that was excluded in this study, what was the regimen used for stress
ulcer prophylaxis by these patients in this study, PPI or H2 blocker?
3. What were the indications for these patients in ICU to receive PEG insertion? PEG insertion
is often not considered for patient with unstable condition or poor life expectancy , such as ICU
patients.
4. Did these patients receive NG insertion and enteral nutrition before PEG implantation? Enteral
nutrition has a significant impact on the occurrence of stress ulcer.
5. Was there any difference for clinical conditions before endoscopic examination between
those patients with gastric mucosal lesion and without, such as sign of bleeding, vital signs or
APACHE II score?
6. Was there any difference for PEG associated complications between those patients with
gastric mucosal lesion and without?
Review for 10.1186/s12876-024-03567-3 (2024)

Title: Risk factors for gastric mucosa lesion in critically ill patients undergoing endoscopy for
percutaneous gastrostomy: a case-control study
Version: 2 Date: 24 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Abstract Exclusion of patients not on PPIs is not adequate because they could be served as
controls Thus if there are enough controls they should be entered in the analysis The same
commment is valid for the methods section Need for PPI use is related to the possibility of stress
related lesions in the stomach Ulcers are not risk factors but  lesions found history of peptic ulcers
are risk factors ! Methods Comorbidities should be decribed in the text Risk factors introduced
in uni and multivariated analysis should be described Statistics Power of the study should be
calculated Was multivariated analysis performed and by which methodology?
Review for 10.1186/s12876-024-03567-3 (2024)

Title: Risk factors for gastric mucosa lesion in critically ill patients undergoing endoscopy for
percutaneous gastrostomy: a case-control study
Version: 2 Date: 29 Oct 2024
Reviewer's report:
Some revisions are necessary before it can be considered for acceptance.
1) The authors should provide references  in the section discussing PEG in the introduction.
2)In addition to p-values, the authors should report the odds ratios, as these will offer more
insight into the effect size and clinical relevance of the findings.
3)A multivariate analysis should be included to account for potential confounding variables and
strengthen the reliability of the conclusions.
4)The Methods section mentions the use of ROC curves, yet this analysis is missing in the
Results section. The authors should clarify why this method was chosen for this type of study,
as ROC analysis is typically applied to evaluate the diagnostic accuracy of a test or model.
5)Focusing exclusively on ICU patients indicated for PEG may introduce bias, as these patients
often have conditions—such as brain injuries—that predispose them to gastric mucosal lesions.
These limitations should be discussed, particularly in relation to the generalizability of the
findings.
6)In the Results section, it would be beneficial to include a summary of the clinical indications
for PEG among the study participants
Review for 10.1186/s12876-024-03567-3 (2024)

Title: Risk factors for gastric mucosa lesion in critically ill patients undergoing endoscopy for
percutaneous gastrostomy: a case-control study
Version: 3 Date: 18 Nov 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Since PPI effect depends in receiving of food close proximity to per os feeding or enteric feeding
is mandatory Otherwise continuous infusion should be provided Abstract Risk factors evaluated
would be better to be defined Methods Data collected should be better defined (eg smoking
habits, alcohol use)  Statistics Power of the study should be calculated
Review for 10.1186/s12876-024-03567-3 (2024)

Title: Risk factors for gastric mucosa lesion in critically ill patients undergoing endoscopy for
percutaneous gastrostomy: a case-control study
Version: 4 Date: 25 Nov 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Methods Were data on serum creatinin  available so that they might be included in the analysis?
Otherwise the study is ready for publication
Review for 10.1186/s12876-024-03567-3 (2024)

Title: Risk factors for gastric mucosa lesion in critically ill patients undergoing endoscopy for
percutaneous gastrostomy: a case-control study
Version: 5 Date: 28 Nov 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Power of the study calculation should be moved from the results into statistics Otherwise the
document is ready for publication and could be accepted
Review for 10.1186/s12876-024-03538-8 (2024)

Title: The moderating effect of dietary fiber intake on the association between sleep pattern and
liver fibrosis in metabolic dysfunction-associated steatotic liver disease: a study from NHANES
Version: 0 Date: 22 Sep 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Because connection of sleeping disorders with fibrosis development has been already studied
based on NHANES data authors tried to enter dietary fiber consumption in the equation The
abstract methods should be changed determining that connection of sleeping patern with fibrosis
development was evaluated taking into consideration fiber consumption  (dichotomus analysis),
age, gender and presence of CVD If there is space they should also mention that patients with
ALD, MeLD or hepatitis were excluded. Data on severity of fibrosis could be provided in
the result section In results findings of multivariated analysis should be presented Intergroup
comparisons could be omitted. Methods Authors should define of social jet lag and sleering
debt were taken into consideration If those parameters were taken into consideration they should
be defined Authors should exclude patients with MASLD and viral hepatitis and those with
ALD or MeLD since alcohol consumption can affect sleeping paterns ; in the same way that
the previous NHANES study did.  A stepwise analysis should be performed if the effect  of
various paremeters need to be evaluated. Exclusion criteria should be removed from the results
to methods section and there a table with a reference in the text for the whole number excluded
is enough Data on fibrosis severity might be given in the text In the text should appear all
significant parameters Findings of univariate analysis should be presented in a table, as well
as those of multivariated analysis and only significant variabled should appear in the text For
fiber consumption a comment should be provided about the result if parametric evaluation was
performed and then it should be given the result of non-parametric (dichotomised by 14.7 g/d)
analysis The stepwise analysis should be preferably replaced by another connecting risk factors
with F3 fibrosis or even cirrhosis Discussion should be adapted accordingly
Review for 10.1186/s12876-024-03538-8 (2024)

Title: The moderating effect of dietary fiber intake on the association between sleep pattern and
liver fibrosis in metabolic dysfunction-associated steatotic liver disease: a study from NHANES
Version: 1 Date: 14 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Abstract The authors should define the aim Do authors try also to identify if sleeping disorders
are related to liver fibrosis? Correlation of fiber consumption to sleeping disorders should be
given The results of multivariate analysis should follow proving that the two risk factors are
independent The same is valid for the results Methods The cutting point for fiber  consumption
should be defined and supported by bibliographic evidence Results multivariated analysis
proving the independent effect of dietary fibers and sleeping defects as well as any overlapping
should precede to any subgroup analysis
Review for 10.1186/s12876-024-03538-8 (2024)

Title: The moderating effect of dietary fiber intake on the association between sleep pattern and
liver fibrosis in metabolic dysfunction-associated steatotic liver disease: a study from NHANES
Version: 1 Date: 14 Oct 2024
Reviewer:  Amira A A Othman
Reviewer's report:
I would like to extend my congratulations to all those involved in this work. All the required
amendments have already been made carefully and satisfactorily. I hope that the research will
be presented to science
Review for 10.1186/s12876-024-03538-8 (2024)

Title: The moderating effect of dietary fiber intake on the association between sleep pattern and
liver fibrosis in metabolic dysfunction-associated steatotic liver disease: a study from NHANES
Version: 2 Date: 22 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Methods Authors should provide definition of high and low fiber diet used in the particular study
Results because F4 fibrosis is expected to cause spleep disterbances dirrectio on connection
between sleep disterbances and liver fibrosis should be defined relations of various risk factors
with MASLD should be differentiated from fibrosis and reporting on fibrosis should be present
in every section
Review for 10.1186/s12876-024-03538-8 (2024)

Title: The moderating effect of dietary fiber intake on the association between sleep pattern and
liver fibrosis in metabolic dysfunction-associated steatotic liver disease: a study from NHANES
Version: 2 Date: 22 Oct 2024
Reviewer:  Amira A A Othman
Reviewer's report:
I would like to extend my congratulations to all those involved in this work. All the required
amendments have already been made carefully and satisfactorily. I hope that the research will
be presented to science
Review for 10.1186/s12876-024-03538-8 (2024)

Title: The moderating effect of dietary fiber intake on the association between sleep pattern and
liver fibrosis in metabolic dysfunction-associated steatotic liver disease: a study from NHANES
Version: 3 Date: 27 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
I donot know if authors could define the direction of interconnection between sleeping disorders
and liver fibrois since fibrosis and especially cirrhosis could affect sleeping paterns Otherwise
the text is ready for publication
Review for 10.1186/s12876-024-03538-8 (2024)

Title: The moderating effect of dietary fiber intake on the association between sleep pattern and
liver fibrosis in metabolic dysfunction-associated steatotic liver disease: a study from NHANES
Version: 4 Date: 30 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Study could be accepted for publication since authors do not intend to make any changes towards
studding reverse causality between sleeping patterns and liver fibrosis
Review for 10.1186/s12876-024-03538-8 (2024)

Title: The moderating effect of dietary fiber intake on the association between sleep pattern and
liver fibrosis in metabolic dysfunction-associated steatotic liver disease: a study from NHANES
Version: 5 Date: 11 Nov 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Abstract Authors should still work with the  language of the text Number of patients included
in the study should be removed from methods section "We grouped the population into low and
high fiber intake groups using the median of dietary fiber intake, with dietary fiber intake < 15
gm/day" this phrase belongs in methods  The phrase above is obscure Do authors mean that after
adjustment for fiber intake sleep patern is related to liver fibrosis? The part of results following
this phrase is also obscure Thus making long short authors should rewrite tthe abstract Methods
Were other hepatides exclusion criterion apart from B and C? Why were those limits of calories
consumption adopted?
Review for 10.1186/s12876-024-03538-8 (2024)

Title: The moderating effect of dietary fiber intake on the association between sleep pattern and
liver fibrosis in metabolic dysfunction-associated steatotic liver disease: a study from NHANES
Version: 6 Date: 14 Nov 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
I think that the study is ready for publication Thus it could be accepted Congratulations to the
authors
Review for 10.1186/s12876-024-03557-5 (2024)

Title: Differential effects of systemic immune inflammation indices on hepatic steatosis and
hepatic fibrosis: evidence from NHANES 1999-2018
Version: 0 Date: 18 Nov 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
NHANES provides the opportunity to get data of patient transient elastography , generaly more
reliable to estimate liver fibrosis than the bunch of nomogrammes authors selected Abstract
Number of patients belongs in the results Methods Numerical values of patients included and
excluded for various reasons in the study belong in the results Only description of entry and
exclusion criterai belongs to methods section  All patients with underlined liver diseases should
be excluded apart from MASLD patients Use of alcohol should be defined so that patients with
MetSLD and ALD could be excluded Use of MASLD definition instead of NAFLD would be
preferable Description of comorbidies and demographic factors included should be described
as in the entry criteria of NHANES Statistics Power of the study should be calculated Results
Significant differences in demographic factors and various comorbidies should be presented in
the text
Review for 10.1186/s12876-024-03552-w (2024)

Title: The additive interaction of healthy lifestyles and genetic susceptibility on colorectal
cancer risk in prediabetes: a large population-based prospective cohort study
Version: 3 Date: 14 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Abstract High and medium PRS apparently compared to low PRS? Although HLF is devided
in favoral anfavoral and intermediate in the results various dimensions were explored The two
sections should keep up  There presentation of intrplay between PRS, HFL and prediabetes is
a expected to be presented. Methods Pregnancy and SIRS presumably refered to the point if
data collection because pregnancy at any point in the past or SIRS from which the patient has
recovered fully I suppose are not exclusion criteria Oragma failure should be defined futher.
Has HLF been validated References should be provided Why authors have selected a 3 grade
stratification of their parameters? Why not a continous or dichotomous stratification? CRC
screening is first reported in statistics It should be defined in methods section Which method was
selected to compare separately CRC risk with HFL or PRS? Why HFL stratification proposed
in methods not used in the third paragraph? What is the utility to perform subgroup analysis
of various parameters of HFL and prediabetes? Multivariated analysis is not enough? Specific
gravity of each risk factor should be calculated?
Review for 10.1186/s12876-024-03552-w (2024)

Title: The additive interaction of healthy lifestyles and genetic susceptibility on colorectal
cancer risk in prediabetes: a large population-based prospective cohort study
Version: 3 Date: 20 Oct 2024
Reviewer's report:
Thank you for inviting me to review the manuscript. I have the following comments.
1. Line 125  I have a concern regarding this study. The authors mention that participants in
the UK Biobank underwent various surveys at baseline, but I'm curious why nearly half of the
individuals are missing lifestyle data. Does this have any impact on the evaluation of the results?
2. Line 133  In the section on healthy lifestyle components, the descriptions of diet and
physical activity are overly simplistic. For instance, regarding diet, it is important to specify the
method used to collect dietary data. Was it through 24-hour dietary recalls or a food frequency
questionnaire? What are the validity and reliability of this method? Were individuals with
abnormal energy intake taken into account? For physical activity, what questionnaire was used
for assessment, and what are its validity and reliability? Alternatively, was physical activity
assessed using a wearable device?
3. Line 156  In the definition of prediabetes, it is important to describe the sample collection and
the relevant processes and methods used for testing.
4. Line 167  What does the Townsend Deprivation Index represent?
5. What is the method for calculating the P value in Table 1?
6. The authors classified the cumulative Healthy Lifestyle Score into "favorable,"
"intermediate," and "unfavorable." Why, then, did they apply a similar grouping for individual
Healthy Lifestyle components in Table 2, and what criteria were used for this classification?
Additionally, why are there only "favorable" and "unfavorable" categories? The authors should
clearly describe this before the analysis.
Review for 10.1186/s12876-024-03552-w (2024)

Title: The additive interaction of healthy lifestyles and genetic susceptibility on colorectal
cancer risk in prediabetes: a large population-based prospective cohort study
Version: 3 Date: 28 Oct 2024
Reviewer's report:
1. More details on the follow-up in the cohort, person-time, and censoring in the analyses need
to be provided.
2. Competing risk analyses may be beneficial as sensitivity analyses to correct for presence of
competing events.
3. Although the hypothesis of this study is examining additive interactions, the manuscript could
benefit from examining in parallel  in the same cohort multiplicative interaction (model with
interaction term) in non-stratified models. In the methods, it is mentioned that multiplicative
interaction is being in fact assessed, but no mention to it is directly provided in the rest of the
manuscript (results, discussion). Synergistic effects in results are mentioned in the title section
but the term needs to be also clarified or consistently referred to throughout the manuscript.
4. Proportional hazards assumptions need to be tested prior to analyses.
5. Is the HLS score validated ? Citations may be needed. Also is the HLS with 5 behaviors
commonly used in other cohorts as opposed to including more behaviors/indicators like sleep
patterns, sedentarism, etc?
6. Fig 3a label “male” is missing
7. More literature examining these interactions on CRC risk in prediabetic population needs to
be provided. Otherwise, if this is the first study examining this hypothesis it needs to be stated.
It is unclear in the text as it is currently.
Review for 10.1186/s12876-024-03552-w (2024)

Title: The additive interaction of healthy lifestyles and genetic susceptibility on colorectal
cancer risk in prediabetes: a large population-based prospective cohort study
Version: 4 Date: 22 Nov 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Language of the text needs further improvement Abstract The last sentence of results should
be placed  before the previous one Methods Numerical values for patients excluded from the
study belong in the results and should be moved there More details should be provided for organ
failure criteria What authors mean by sex discrepancies? Healthy lifestyle components should
be futher defined Statistics Power of the study calculation is advisable Results Were all HLFs
equally important?
Review for 10.1186/s12876-024-03515-1 (2024)

Title: The Relationship between Food Components and Constipation: A Cross-Sectional Study
Version: 1 Date: 21 Sep 2024
Reviewer's report:
The present investigation sought to examine the correlation between dietary consumption and
the likelihood of experiencing constipation. It appears that the present research lacks sufficient
novelty for publication.
• Given the significant variability in dietary consumption across different seasons and days,
utilizing merely two food recalls is not a robust method for evaluating food intake.
• Since the study incorporated both constipated and non-constipated individuals, the design
appears to resemble that of a case-control study.
• The manuscript requires a thorough grammatical review and adjustments concerning verb
tense.
• Numerous studies exist that explore the relationship between dietary intake and constipation,
which should be referenced in the introduction.
• The application of the Shapiro-Wilk test to assess normality in a sample with such high
participation does not seem appropriate. Please verify this.
Review for 10.1186/s12876-024-03550-y (2024)

Title: Increasing incidence of mycotoxicosis in South-Eastern Germany: A Comprehensive
Analysis of Mushroom Poisonings at a University Medical Center
Version: 1 Date: 16 Sep 2024
Reviewer's report:
It is an interesting article, though not much new than  what we have already known about
mushroom poisoning. The design and contents of this study is satisfied. However, the authors
using the demonstrated case to emphasize  the value of the  potential use of plasmapheresis  in
managing  mushroom poisonings,  clinically it may not be  able to judge,   however, just viewing
the laboratory data, I am not sure whether  this case did require the  use of plasmapheresis or not.
By the way, in Abstract, there more likely a mistyping in the Methods  paragraph, in which , the
"clinical changes"  suppose to be "climate changes", instead.
Review for 10.1186/s12876-024-03537-9 (2024)

Title: Association of “A Body Shape Index” with the risk of developing colorectal cancer in
U.S. patients with metabolic syndrome: Evidence from the NHANES 1999-2018
Version: 1 Date: 20 Aug 2024
Reviewer's report:
The submitted manuscript by Kurexi et al is on the association between a novel index A Body
Shape Index (ABSI) and the risk of colorectal cancer (CRC) among patients with metabolic
syndrome. Although it is interesting, the manuscript critically lacks the rationale for using this
index that is simply reflecting waist circumference divided by some variation of BMI and height.
This manuscript does not seem to add any value to the literature unless the authors reinforce
their rationale for using this index.
Some specific points:
--How ABSI is calculated or at least what it is should be written explicitly in the Methods section
of the Abstract and also recommended to introduce the concept in the Introduction (i.e., write a
paragraph about ABSI and introduce what it is and how it is calculated in the Introduction).
--ABSI is calculated WC/(#BMI#^(2/3)×#height#^(1/2) ), and the authors explained this index
to “accurately evaluate abdominal fat distribution independent of BMI, focusing on WC relative
to height and weight.” How is this independent of BMI when BMI is in fact included in the
equation? Also, BMI itself has height in its formula, so the denominator somehow has two
heights. With the 2/3 and ½ power to BMI and height, I do not completely understand what it
is doing, and neither will the readers. While the readers could go back to the original Krakauer
paper, authors should fully explain this in this manuscript given how this index is not generally
used. Also, the authors need to more fully explain the rationale for using this index.
--Additionally, was ABSI used to look at the association with other outcomes? In the Discussion,
cite any other published articles that used ABSI.
--What model was fit to obtain ROC? Explain in the Methods.
Review for 10.1186/s12876-024-03537-9 (2024)

Title: Association of “A Body Shape Index” with the risk of developing colorectal cancer in
U.S. patients with metabolic syndrome: Evidence from the NHANES 1999-2018
Version: 1 Date: 15 Sep 2024
Reviewer's report:
1) It would be beneficial to conduct the analysis using additional diagnostic criteria for metabolic
syndrome (MetS), such as the IDF criteria.
2) Information regarding risk factors for colorectal cancer (CRC), such as an individual's diet
and physical activity levels, has not been collected. Additional key risk factors include family
history, polyps, and inflammatory bowel disease (IBD).
3) The ROC curve analysis should incorporate the waist-to-height squared (Waist-to-Height²)
ratio, as this parameter is more appropriate compared to those previously utilized.
4) In the section on logistic regression, it is essential to describe the method used to select
the variables included in the multivariate model, as well as how the assumptions of logistic
regression were assessed.
Review for 10.1186/s12876-024-03537-9 (2024)

Title: Association of “A Body Shape Index” with the risk of developing colorectal cancer in
U.S. patients with metabolic syndrome: Evidence from the NHANES 1999-2018
Version: 2 Date: 11 Oct 2024
Reviewer:  Amira A A Othman
Reviewer's report:
I would like to extend my congratulations to all those involved in this work. All the required
amendments have already been made carefully and satisfactorily. I hope that the research will
be presented to science
Review for 10.1186/s12876-024-03537-9 (2024)

Title: Association of “A Body Shape Index” with the risk of developing colorectal cancer in
U.S. patients with metabolic syndrome: Evidence from the NHANES 1999-2018
Version: 2 Date: 13 Oct 2024
Reviewer's report:
I remain unconvinced about the authors' choice to look at ABSI. Although they argue that ABSI
is independent of BMI and present it as a novel measure, they do not provide a compelling
rationale for why it was examined in this study.
Here are the reasons for my continued skepticism:
--The authors have not adequately addressed my earlier question regarding whether there are
any published articles that previously used ABSI. They mentioned that they addressed this on
page 13 but did not cite any. This raises doubts about the practical applicability and broader
acceptance of ABSI (as there are no other previously published papers that used ABSI).
--While the authors show the supposed superiority of ABSI compared to BMI, weight, height,
etc (figure 3), they do not seem to have fully understood my question regarding the model used
to generate the ROC curves. Their response that they used a “pure ROC curve analysis” does
not clarify the methodology, leading me to question the validity of their statistical approach.
Without a clear explanation of the model used to produce the ROC curves, I find it difficult to
trust their AUC results. Also, the lack of knowledge and transparency on their own methodology
used to create the ROC curves raise serious concerns about reproducibility of their results. Also,
the authors should also report 95% confidence interval for these AUCs.
Review for 10.1186/s12876-024-03537-9 (2024)

Title: Association of “A Body Shape Index” with the risk of developing colorectal cancer in
U.S. patients with metabolic syndrome: Evidence from the NHANES 1999-2018
Version: 2 Date: 26 Oct 2024
Reviewer:  Mohamed A. Abdelrazek
Reviewer's report:
The authors have made all necessary amendments and corrections and the article is now ready
for publication in its current form.
Review for 10.1186/s12876-024-03537-9 (2024)

Title: Association of “A Body Shape Index” with the risk of developing colorectal cancer in
U.S. patients with metabolic syndrome: Evidence from the NHANES 1999-2018
Version: 3 Date: 06 Nov 2024
Reviewer's report:
Thank you for being responsive to my comments. The authors have fully addressed all of my
concerns.
Review for 10.1186/s12876-024-03509-z (2024)

Title: Anti-CdtB and anti-vinculin antibodies to diagnose irritable bowel syndrome in
inflammatory bowel disease patients
Version: 1 Date: 24 Oct 2023
Reviewer:  Ilhami Yüksel
Reviewer's report:
In this prospective observational study, the authors aimed to determine the clinical utility of
an antibody-based strategy to diagnose IBS/IBS-D in IBD patients that present with chronic
diarrhea despite endoscopic remission.
They have 4 groups, which include Active IBD, Quiescent IBD, Diarrhea-predominant irritable
bowel syndrome and Healthy controls.
In the literature, large cohort study showed that higher levels of antibodies to CdtB and vinculin
were detected in IBS-D subjects as compared to IBD subjects and healthy controls. However,
in the presented study there is no difference between diarrhea-predominant irritable bowel
syndrome and healthy controls in terms of anti-CdtB and anti-vinculin antibodies in the Brazilian
population. Therefore, in the Brazilian IBD population, such markers could not be used to
differentiate between active and quiescent IBD or between IBS and IBS-D.
Review for 10.1186/s12876-024-03509-z (2024)

Title: Anti-CdtB and anti-vinculin antibodies to diagnose irritable bowel syndrome in
inflammatory bowel disease patients
Version: 1 Date: 16 Nov 2023
Reviewer's report:
Very interesting paper. However I would like more detailed section Materials and methods.
For example:
In your Discussion you state:
“In our study, both the active and quiescent IBD groups had a long-standing disease. “
The materials and methods do not lead to conclude that…
Also I’m interested in your infectious colitis screening before enroling in the study. Were all
patients (not healthy controls) in any way screened for infective colitis, and which method did
you use.
Please check references.
Review for 10.1186/s12876-024-03509-z (2024)

Title: Anti-CdtB and anti-vinculin antibodies to diagnose irritable bowel syndrome in
inflammatory bowel disease patients
Version: 2 Date: 25 Dec 2023
Reviewer:  Ilhami Yüksel
Reviewer's report:
Again.
In this prospective observational study, the authors aimed to determine the clinical
utility of an antibody-based strategy to diagnose IBS/IBS-D in IBD patients that present with
chronic diarrhea despite endoscopic remission. They have 4 groups, which include Active IBD,
Quiescent IBD, Diarrhea-predominant irritable bowel syndrome and Healthy controls. In the
literature, large cohort study showed that higher levels of antibodies to CdtB and vinculin were
detected in IBS-D subjects as compared to IBD subjects and healthy controls. However, in the
presented study there is no difference between diarrhea-predominant irritable bowel syndrome
and
healthy controls in terms of anti-CdtB and anti-vinculin antibodies in the Brazilian population.
Therefore, in the Brazilian IBD population, such markers could not be used to differentiate
between active and quiescent IBD or between IBS and IBS-D.
Review for 10.1186/s12876-024-03509-z (2024)

Title: Anti-CdtB and anti-vinculin antibodies to diagnose irritable bowel syndrome in
inflammatory bowel disease patients
Version: 2 Date: 05 Feb 2024
Reviewer's report:
Dear authors,
IBS and IBD are diseases that can really be confused and overlapping today. I congratulate you
for addressing this issue. However, I have some comments about the article, which you can find
below.
1.It is stated in the article that only patients with a stool count of 3 or more are included. However,
I think it would be necessary to add the concept of time to this number in order to call it chronic
diarrhea. A statement such as the duration of diarrhea is more than 4 weeks can be added to
this section.
2.. Although C. jejuni & Giardiasis were not examined in these patients, it was written in the
discussion section by commenting on the general population. I think that these infectious factors,
which were not examined in the study, should be excluded in the discussion section, and it is
not right to make comments based on their frequency in the general population.
3.The numbers of Crohn's and ulcerative colitis patients are not equal. The question arises
whether the markers examined differ between these diseases. A paragraph can be added to the
discussion section on this topic.
Was a subgroup analysis performed by equalizing the numbers of Crohn's and ulcerative colitis
patients?
4.Since it is inevitable that the use of immunosuppressant drugs will affect the markers, would
it be better if the first diagnosed patients were included in the study?
Why wasn't such a study design considered?
In the study conducted by Pimentel et al., were the patients receiving immunosuppressive
treatment? can be added to the discussion.