Review for 10.1186/s12876-023-02967-1 (2023)

Reviewer’s report
Title: 
Establishment and validation of a prognosis nomogram for MIMIC-III
patients with liver cirrhosis complicated with hepatic encephalopathy
Version: 
0 
Date: 
29 Nov 2022
Reviewer's report:
I read with interest this article on the development of nomogram to predict 90-
day survival rate of patients with hepatic cirrhosis with encephalopathy. I have
following comments regarding the manuscript:
1. Please expalin the reason behind making two cohorts from the same database
to validate the nomogram. Both the cohorts have same clinicodemographic
features as shown in Table 1. I would rather take the validation cohort from
another database or patient population.
2. Please include the etiology of liver cirrhosis, grade of hepatic encephalopathy,
serum ammonia levels in the survival analysis and see whether they affects the
90-day survival rates.
3. Table 1 should be divided in to two tables. In Table 1, the baseline
characteristics of survived and expired patients of training cohort should be
compared and in Table 2 the characteristics of survived and expired patients in
validation cohort should be compared. It will be beneficial for the readers.
4. Please mention the 90-day survival rates of training and validation cohorts for
the benefit of the readers.
Declaration of competing interests
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paper?
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I declare that I have no competing interests.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes
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