Review for 10.1186/s12876-022-02590-6 (2022)

Reviewer’s report
Title: 
Evaluating Cost Per Remission and Cost of Serious Adverse Events of
Advanced Therapies for Ulcerative Colitis
Version: 
0 
Date: 
26 Apr 2022
Reviewer's report:
1. " Wholesale acquisition cost (WAC), accessed April 8, 2021, from
REDBOOK [16], was used to calculate costs of induction and maintenance
regimens for labeled dosing (Table 1). WAC represents the publicly available list
price for a drug and does not include rebates or discounts."REDBOOK.
Micomedex. Greenwood Village, CO, USA: Truven Health Analytics." 
The above reference is inaccessible publicly. please provide supplementary data
for each drug cost separately (printout or screen shots from the REDBOOK will
be acceptable for me. 
2. The authors write: "Comparative efficacy and safety inputs were derived from
a network meta-analysis of pivotal trials [5,15]. Numbers needed to treat (NNT)
for response and remission from the network meta-analysis were used to
estimate drug costs associated with achieving the respective outcomes at 52
weeks."3. 
-Reference 15 is a poster presentation from the same authors, i dont see the full
text for that abstract
-Reference 5 is a network analysis, please identify the exact NNT. 
Please provide exact reference for NNT calculations for each drug 
3. Figure 4: Please report actual costs of SAE/SIs and not the cost referenced to
vedolizumab.
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