Review for 10.1186/s12876-020-01188-0 (2020)

Reviewer’s report
Title: Diagnostic efficacy of double-balloon enteroscopy in patients with suspected isolated small
bowel Crohn’s disease
Version: 1 Date: 05 Sep 2019
Reviewer: Ilhami Yuksel
Reviewer's report:
In the present study, the Authors aimed to investigate the value of double-balloon enteroscopy (DBE)
for diagnosis of isolated small bowel Crohn's disease (CD). This is so valuable study, however I have
some questions and comments, which should be addressed by the Authors. 
Major comments
1. The study design appears confused because of DBE was used as a diagnostic tool and also an
activity detector in the present study. 
I think that the Authors did not need to evaluate CD activity or respond to treatment. In the current
study, DBE was just used as a diagnostic tool in suspected isolated small bowel CD. Thus the Authors
should omit the part of the paper that does not include diagnostic estimation of DBE for making the
diagnosis of isolated small bowel CD.  
2. In the material and method, the Authors mentioned that EGD, colonoscopy, CTE or enhanced
computed tomography (CT), and VCE were done in some cases. CTE and VCE were performed in just
some cases, although all patients underwent CT (table 1). CT is satisfactory for the suspicion of small
bowel CD. The Authors might exclude the results of CTE and VCE from the main text and tables. 
3.  This  study  is  also  not  a  surveillance  study,  so  Authors  should  omit  surveillance  results  and
information  like  "three  patients  underwent  DBE  surveillance  after  treatment  and  were  found  to
improve, on the basis of endoscopic images…". 
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?
If an additional statistical review is recommended, please specify what aspects require further
assessment in your comments to the editors.
I recommend additional statistical review
Quality of written English
Please indicate the quality of language in the manuscript:
Acceptable
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