Review for 10.1186/s12876-019-1005-1 (2019)

Reviewer ’s report  
 
Title: Histological improvement in Chronic hepatitis B patients treated with bicyclol ：real 
world experience  
 
Version: 0 Date: 27 Jan 2019  
 
Reviewer: Puja Sakhuja  
 
Reviewer's report:  
 
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The authors have studied the effect of bicyclol on Chronic Hepatitis B patients, using those 
taking antiviral therapy as controls. although the study is well written, a lot of language 
corrections are required. Furthermore, they have not extensively review ed the available literature 
on bicyclol in viral hepatitis.  
Details of how treatment should be withdrawn gradually should be given and no such withdrawl 
protocol has been used in this study.  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your  comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statist ical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I recommend additional statistical review  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
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1. Have you in t he past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
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financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursemen ts, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to t his paper?  
 
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below.  If your reply is yes to any, please give details below.  
 
1. No  
 
2. No  
3. No  
4. No  
5. No  
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