Review for 10.1186/s12876-019-1013-1 (2019)

Reviewer ’s report  
 
Title: A case report of psychiatric symptoms following direct -acting antiviral and ribavirin 
combination therapy for chronic hepatitis C in a patient with innate anxiety  
 
Version: 3 Date: 22 May 2019  
 
Reviewer: Reviewer 2  
 
Reviewer's report:  
 
REVISION ASSESSMENT FROM THE ACADEMIC PEER REVIEWER:  
Has the author addressed your concerns sufficiently for you to now recommend the work as a 
technically sound contribution?  
Yes 
 
Reviewer comments: It is a sound publication.  
ADDITIONAL REQUESTS/SUGGESTIONS:  
However, I would suggest alternate language sol ely for the purpose of ensuring optimal English 
language use:  
1) Page 8, final sentence: suggest changing "we are planning to retrying the DAA therapy" to 
"we are planning to retry an alternate DAA regimen without ribavirin"  
2) Page 10, final paragraph, 1s t sentence: suggest changing "in conclusion ..." to "in conclusion, 
psychiatric disease is common among patients with chronic HCV infection, and those 
undergoing IFN -based treatment, but our case signals the possibility of psychiatric effects with 
oral DAA  regimens as well."  
Are the methods appropriate and well described?  
If not, pl ease specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
  
Are the conclusions drawn adequately supported by the da ta shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript : 
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding , or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the  publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, writ e 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
This reviewer has been recruited by a partner organization, Research Square. Reviewers with 
declared or apparent competing interests are not utilized for these reviews. This reviewer has 
agreed to publication of their comments online und er a Creative Commons Attribution License 
attributed to Research Square and was paid a small honorarium for completing the review within 
a specified timeframe. Honoraria for reviews such as this are paid regardless of the reviewer 
recommendation.  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
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CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal