Review for 10.1186/s12876-022-02121-3 (2022)

Reviewer’s report
Title: 
Severe tyrosine-kinase inhibitor induced liver injury in metastatic renal
cell carcinoma patients: Two case reports assessed for causality using the
updated RUCAM and review of the literature
Version: 
2 
Date: 
04 Jan 2022
Reviewer's report:
The authors answered all reviewers' comments and improved the quality of the
manuscript. Therefore, I recommend to accept the manuscript in the current
form.
I have one last minor remark: Reviewer 1 suggested to change the word
"hepatotoxicity" to "liver injury". However, I agree with the authors that in
oncology, the wording "hepatotoxicity" is more often used and I understand their
concerns. Maybe the word hepatotoxicity can still be mentioned as key word
(and/or be used at some instances in the text also), so that oncologists using the
term in literature search tools can find the article if published.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes