Review for 10.1186/s12876-019-1064-3 (2019)

Reviewer ’s report  
 
Title: The different expression of caspase -1 in HBV -related liver disease and acts as a biomarker 
for acute -on-chronic liver failure  
 
Version: 1 Date: 26 May 2019  
 
Reviewer: Claudia Mandato  
Reviewer's report:  
The manuscript ent itled: The different expression of caspase -1 in HBV -related liver disease and 
acts as a biomarker for acute -on-chronic liver failure is interesting and well described.  
The English language should be re -edited,  especially  in introduction and discussion sec tion 
where some sentences appear not understandable. I add my note on the uploaded version of the 
manuscript.  
I also suggest to extensively discuss the physio pathological  meaning of the  increased tissue  
expression  and concurrent  reduced serum levels o f Caspase 1 in ACLF.  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn  adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review is r ecommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
I recommend additional statistical review  
 
  
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Not suitable for publication unless extensively edited  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an 
organisation that may in any way gain or lose financia lly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold o r are you currently applying for any patents relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do yo u have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the  above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
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on my report to the authors and, if the manuscript is accepted for publication, my named report 
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