Review for 10.1186/s12876-020-01469-8 (2020)

Reviewer’ s report
Title: The association of genetic polymorphisms and nonalcoholic fatty liver disease in a
longitudinal study
Version: 0Date: 25 May 2020
Reviewer's report:
This study investigated the longitudinal association between genetic variants and NAFLD. After
mean 39 months follow-up, the authors analyzed the difference of SNPs between the developingNAFLD and non-developing NAFLD, the regressed group and non-regressed group. They foundthat NAFLD were not associated with genetic variants in the Korean population. However, somesignificant defects could be ignored.
1. Actually, the effect of genetics (SNPs) may be slow and could be compensated by other factors.
In this study, the median follow-up duration was 39 months; the period may be short to follow thechange of NAFLD.2. During the follow-up, whether the authors recorded the life style and dietary favor of thesubjects? The effect of life and diet may surpass the effect of SNPs, therefore, the actuallyassociation of SNPs with the development of NAFLD could be observed.3. The selection of the subjects may affect the results that some patients from the same sampledpopulation in both sets.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
No
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Unable to assessAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I recommend additional statistical review
Quality of written English
Please indicate the quality of language in the manuscript:
AcceptableDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of this
manuscript, either now or in the future?
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financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
NO
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