Review for 10.1186/s12876-020-01192-4 (2020)

Reviewer ’s report  
 
Title: A Case Report of a novel 22 bp duplication within exo n 1 of the UGT1A1 in a Sudanese 
infant with Crigler -Najja r Syndrome type I  
 
Version:  1 Date: 03 Feb 2020  
 
Reviewer: Shin'Ichi Ikushiro  
 
Reviewer's report:  
 
This manuscript described novel genotype of UDP -glucuronosyltransferase family 1A1 gene ( 
UGT1A1 ) with Crigler -Najjar syndrome type I (CN -I)  in Sudanese patient. Mutations of 
UGT1A1 cau se the hereditary unconjugated hyperbilirubinemias (CN -I, CN -I, and GS). The 
authors have appropriately revised the manuscript according to reviews suggestions. I would like 
to accept revision in revised version with some efforts.  
 
Are the methods appropriate and well described?  
If not, please specify what is re quired in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, plea se explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publicat ion of this 
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2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you current ly applying for any patents  relating to the content of the 
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4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any ot her financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
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below. If your reply is yes to any, please giv e details below.  
 
I declare that I have no competing interests.  
 
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I agree to the open peer review policy of the journal