Review for 10.1186/s12876-022-02347-1 (2022)

Reviewer’s report
Title: 
Comparative Efficacy and Safety of Infliximab and Vedolizumab Therapy
in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-
analysis
Version: 
0 
Date: 
27 Mar 2022
Reviewer: 
HAKAN AKIN
Reviewer's report:
Dear Authors,
Thank you very much for giving me the chance to review this manuscript. I
think it is a current hot topic and clinical need to compare the efficacy and safety
of infliximab and vedolizumab treatment groups comprehensively both in
moderate to severe CD and UC patient cohorts. Authors did a very good job
using current guideline for preparation of metaanalysis & sytematic reviews.
They reported a well standardized manuscript. All the methods and results were
well documented. With supplemental files, the authors gave the details of
methods including search strategy and also results for all of the related Forrest
Plots in details. The authors discussed the strengths and limitations of the study
very nicely. I could not find any methodological defect of the study which the
authors did not discuss in limitations part. My advice will be 
'accept without
revision'
Thanks in advance..
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes