Review for 10.1186/s12876-021-02027-6 (2021)

Reviewer’s report
Title: 
Eradication of Helicobacter pylori may improve dyspepsia in the elderly
for the long term
Version: 
0 
Date: 
03 May 2021
Reviewer's report:
I read with interest the report on the effect of eradication therapy on dyspeptic
symptoms in elderly patients. The study is nicely designed and conducted.
Please find here below my comments:
Abstract: the conclusion is too reductive with respect to what the authors did and
somewhat misleading, as Hp eradication is recommend beyond presence of
dyspepsia, especially in Japan with a very high prevalence of GC, as correctly
stated in the Introduction. 
Iintroduction: lines 33-36: this sentence is written twice.
Methods: As correctly stated, accurate diagnosis of Hp infection requires at least
two diagnostic methods. The authors state also that efficacy of eradication
treatment was verified by UBT. I would have been more correct to verify
successful eradication by the same tests which were positive pre-treatment. This
may be especially true in those patients with borderline UBT values. 
Discussion: In contrast to the declarative title chosen by the authors, the
discussion section is not really contextualized on this topic, is it is general and
not tailored to elderly patients who are the target subjects of the study
population. Further, arguments should be commented (for example autoimmune
gastritis very common in elderly subjects...)
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
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Yes
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Yes
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from apparent manipulation?
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