Review for 10.1186/s12876-021-01950-y (2021)

Reviewer’s report
Title: 
Long term survival of a patient with microsatellite stable refractory
colorectal cancer with regorafenib and PD-1 inhibitor sintilimab – A Case
Report and Review of Literature
Version: 
1 
Date: 
10 Sep 2021
Reviewer's report:
I can see much improvement. It is acceptable to be publish now.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
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from apparent manipulation?
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