Review for 10.1186/s12876-021-01873-8 (2021)

Reviewer’s report
Title: 
Comorbid early esophageal cancer and Gongylonema pulchrum infection:
a case report
Version: 
0 
Date: 
09 Jun 2021
Reviewer's report:
The manuscript entitled "Comorbid early esophageal cancer and Gongylonema
pulchrum infection: a case report" describes for the first time the case of a human
presenting both esophageal G. pulchrum infection and early esophageal cancer.
Overall, the work is well presented and reports the possible role of G. pulchrum
in the development of the esophageal carcinoma, providing a new hypothesis of
tumorigenesis. I recommend some minor corrections before publication.
Background
Line 39: please add a reference. Suggested reference: 
Setsuda et al., 2018 Gongylonema infection of wild mammals in Japan and
Sardinia (Italy). Journal of Helminthology, 94, E13.
Varcasia, A., Scala, A., Zidda, A., Cabras, P.A., Gaglio, G., Tamponi, C., Pipia,
A.P., Setsuda, A., Sato, H. First record of Gongylonema nepalensis in domestic
and wild ruminants in Europe
(2017) Veterinary Parasitology, 246, pp. 11-18. 
Line 39: write Gongylonema in full after dot. 
Case presentation
Line 50: please specify when (month and year) the parasite was recovered during
the first endoscopy in a local hospital. 
Discussion and conclusions
Line 104: correct Gongylonema pulchrum to G. pulchrum
Figure legends
Line 146 and 149: write Gongylonema pulchrum in italics.
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Declaration of competing interests
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1
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Do you have any non-financial competing interests in relation to this
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If you can answer no to all of the above, write 'I declare that I have no competing
interests' below. If your reply is yes to any, please give details below.
The manuscript entitled “Comorbid early esophageal cancer and Gongylonema
pulchrum infection: a case report” describes for the first time the case of a
human presenting both esophageal G. pulchrum infection and early esophageal
cancer. Overall, the work is well presented and reports the possible role of G.
pulchrum in the development of the esophageal carcinoma, providing a new
hypothesis of tumorigenesis. I recommend some minor corrections before
publication.BackgroundLine 39: please add a reference. Suggested reference:
Setsuda et al., 2018 Gongylonema infection of wild mammals in Japan and
Sardinia (Italy). Journal of Helminthology, 94, E13.Varcasia, A., Scala, A.,
Zidda, A., Cabras, P.A., Gaglio, G., Tamponi, C., Pipia, A.P., Setsuda, A., Sato,
H. First record of Gongylonema nepalensis in domestic and wild ruminants in
Europe(2017) Veterinary Parasitology, 246, pp. 11-18. Line 39: write
Gongylonema in full after dot. Case presentationLine 50: please specify when
(month and year) the parasite was recovered during the first endoscopy in a local
hospital. Discussion and conclusionsLine 104: correct Gongylonema pulchrum
to G. pulchrumFigure legendsLine 146 and 149: write Gongylonema pulchrum
in italics.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes