Review for 10.1186/s12876-020-01433-6 (2020)

Reviewer’ s report
Title: Highly proliferative anal neuroendocrine carcinoma: Molecular and clinical features of a
rare, recurrent case in complete remission
Version: 0Date: 23 Apr 2020
Reviewer: C. Peirce
Reviewer's report:
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Very interesting article with unique findings and an excellent patient outcome for a disease with
traditionally very poor outlook.
Was the original operation an abdominoperineal excision of the rectum presumably?Why do the authors think that Chromogranin A was not identified in the recurrent samples?Which, if any, of the chemotherapeutic regimens do the authors now recommend as first line? 3
different combinations were used, possibly with synergistic effects, so it might be hard tocomment.
What surveillance, if any, is the patient still undergoing?
Are the methods appropriate and well described?
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YesDoes the work include the necessary controls?
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YesAre the conclusions drawn adequately supported by the data shown?
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YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?
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assessment in your comments to the editors.
Not relevant to this manuscriptQuality of written English
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Acceptable
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