Review for 10.1186/s12876-021-01695-8 (2021)

Reviewer’s report
Title: 
Vaping-Associated Esophagitis: Case Report
Version: 
0 
Date: 
30 Jan 2021
Reviewer's report:
1. Base on this case, it appears that vaping may be associated with poorly
controlled GERD. Thus the authors' conclusion that vaping is associated with
esophagitis may cause ambiguity because the reader first thinks of healthy
people. Please clarify this point in the discussion.
2. On page 4, line 38, the author described "he started vaping
tetrahydrocannabinol (THC) and nicotine,". However, it is confusing that on
page 5, line 43, and page 5, line 50, the author wrote "THC alone has been
shown to decrease transient lower esophageal sphincter relaxations, and thereby
reflux episodes, further suggesting vaping as an independent trigger,", "Like
smoking, the mechanism of injury in vaping maybe, at least in part, due to the
effects of nicotine,", does the term "vaping" refer exclusively to "vaping
nicotine" in these two places? What about elsewhere in the article? 
3. Page 5, line 43," THC alone has been shown to decrease transient lower
esophageal sphincter relaxations, and thereby reflux episodes, further suggesting
vaping as an independent trigger", yet the original text of the reference 4 is
"delta (9)-THC significantly reduced the number of transient lower oesophageal
sphincter relaxations and caused a non-significant reduction of acid reflux
episodes in the first postprandial hour. But, delta (9)-THC significantly reduced
basal lower oesophageal sphincter pressure." Apparently, not enough to support
the author's conclusion, please explain.
4. Kindly include an endoscopic image of the esophagus after treatment, if
available.
5. As the authors mentioned in line 50-53, "Like smoking, the mechanism of
injury in vaping may be, at least in part, due to the effects of nicotine", have
there been any reported cases of severe esophagitis associated with smoking?
What are the details? And are there any possible differences in the injure caused
by vaping and smoking to raise extra concerns? Please discuss.
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