Review for 10.1186/s12876-017-0576-y (2017)

Reviewer ’s report  
 
Title: Uridine stimulate laxative effect in the loperamide -induced constipation of SD rats 
through  the regulation of mAChRs signaling pathway and mucin secretion  
 
Version: 0 Date: 02 Jul 2016  
 
Reviewer: Yik Ian  
 
Reviewer's report:  
 
I would like to congratulate the authors for this well -designed study.  
 
 
However, I have few comments that I would like to draw the attention for the authors:  
 
 
 
 
1. Common grammatical & punctuation errors throughout the manuscript that will require 
the attention and corrections by the authors before this manuscript can be conside red 
suitable for publication  
 
 
2. Detailed methodology but can be more simplified, just my suggestion.  
 
 
3. The results section included with it the implications and these should be separated as the 
implications should be included in the discussion section.  
 
 
4. I feel that the discussion is too superficial and not in depth to adequately discuss and 
express the significance of each findings/results adequately, together with its implications 
in the treatment for chronic constipation in human counterparts, if the se results are to be 
translated from bench to bedside.  
 
 
 
 
 
 
 
 
 
 
 
Are the methods appropriate and well described?  
If no t, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the co nclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
No 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistica l review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, fu nding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially fro m the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization th at 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above,  write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
I agree to the open peer review policy of the journal. I understand that my name will b e included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
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which I do not wish to be included in my named report can be included as  confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal