Review for 10.1186/s12876-020-1164-0 (2020)

Reviewer ’s report  
 
Title: The association between disease activity and patient -reported outcomes in patients with 
moderate -to-severe ulcerative colitis in the United States and Europe  
 
Version: 0 Date: 05 Nov 2019  
 
Reviewer: Joerg Edelmann  
 
Reviewer's report:  
 
The two remission groups (" Deep Remission" vs. "Remission") show few differences, ma ybe 
because of a potential bias as patients without Endoscopy were considered as "Remission", and 
not "Deep remession".  It would be interesting to conduct a Analysis putting the both Remission 
groups together and compare with active disease Group.  
 
The T reatment history of the patients was not included in the Analysis, althoug availabel in 
database.  
 
Potential bias, as all available Outcome data was used, even if the patients did not have 
completed Data on all Outcomes.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls ar e required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscr ipt or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what as pects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written E nglish  
Please indicate the quality of language in the manuscript:  
Acceptable  
 
Declaration of competing interests  
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future?  
 
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that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
 
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below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
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