Review for 10.1186/s12876-022-02319-5 (2022)

Reviewer’s report
Title: 
Oncologic outcome of colon cancer with perforation and obstruction
Version: 
0 
Date: 
04 Feb 2022
Reviewer's report:
The study investigated the prognosis of the colon cancer with perforation and
obstruction. I have some comments as follows:
1. In the methods section, the cases with follow-up time shorter than 3 months
were excluded. But in Fig.1, a case with follow-up time < 12 months was
excluded.
2. Table 1 should include the comparisons of pathological stage (pTNM),
histological subtype.
3. If available, the molecular profiles such as mismatch repair
protein/microsatellite instable status, Braf/Ras mutant status of the perforation
and obstruction cases should be provided, which may also influence the
prognosis.
4. Was there any difference in the treatment, especially the administration of
target therapy or immunotherapy, between perforation and obstruction group
after recurrence? 
5. The analysis of risk factors associated with OS and RFS should include age
and gender.
6. Although the difference did not reach a statistically significant level, the
combination of perforation and obstruction group demonstrated a trend of better
prognosis than IIIc group. If obstruction group alone is compared to the IIIc
group, there may be significant difference? 
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
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Yes
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Yes
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from apparent manipulation?
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