Review for 10.1186/s12876-023-02661-2 (2023)

Reviewer’s report
Title: 
Real-world systemic sequential therapy with regorafenib for recurrent
hepatocellular carcinoma: analysis of 93 cases from a single center
Version: 
0 
Date: 
19 Jul 2022
Reviewer's report:
In the manuscript titled " Real-world systemic sequential therapy with
regorafenib for recurrent hepatocellular carcinoma: analysis of 93 cases for
single center ", the authors performed a comprehensive analysis for advantages
of combination therapy on patients with advanced HCC who fail to respond after
first-line systematic therapy,
This manuscript is well structured. However, there are a few minor points that
should be taken into account before considering this manuscript for publication:
The paper should be grammatically checked since there are several mistakes. 
The authors should provide a workflow in the method part because they have
used several packages and a workflow would help the audiences to follow the
taken steps and understand the reason for taking steps.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes