Review for 10.1186/s12876-018-0785-z (2018)

Reviewer ’s report  
 
Title: Intestinal Candida parapsilosis isolates from Rett syndrome subjects bear potential virulent 
traits and capacity to persist within the host  
 
Version: 1 Date: 19 Mar 2018  
 
Reviewer: Gianluca Ianiro  
 
Reviewer's report:  
 
Dear Authors,  
 
Thank you for your replies.  
About my comments:  
Comments 1) and 2) are satisfied from your reply, totally. Please just briefly highlight that your 
group did a previous study that has already assessed the gut bacteriome in the same population.  
Comments 3) I mean that you assessed only the cultivable part of the gut mycobiota, while other 
studies used a metagenomic approach (e.g. Sokol et al - Gut 2017 
https://www.ncbi.nlm.nih.gov/pubmed/26843508 ).  However, this is not an absolute drawback in 
my opinion. Please just briefly include it as a limitation of the  study in the discussion.  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls ? 
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
  
Are you able to assess any statistics in  the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five year s received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in a ny way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding , or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you  can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
None  
 
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