Review for 10.1186/s12876-022-02201-4 (2022)

Reviewer’s report
Title: 
AL amyloidosis with primary presentation of multiple serous cavity
effusion and severe cholestasis: A case report and review of literature
Version: 
1 
Date: 
11 Oct 2021
Reviewer: 
Tamer Rezk
Reviewer's report:
This is an interesting case of a patient with what appears to be nephrotic
syndrome and liver failure, with congo red posivitiy on liver biopsy and assumed
AL amyloidosis. I say assumed as the presence of a lambda light chain clone
does not prove the presence of AL amyloidosis. Unfortunately the authors have
not demonstrated that this is a case of AL amyloidosis with a primary hepatic
presentation.
In order to classify this as AL amyloidosis, the patient requires IHC staining with
lambda or kappa antibody (as well as staining for AA amyloidosis and other
rarer hereditary causes of amyloidosis as exclusion). This is particularly relevant
in this case as there was a family history of liver failure and death. 
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