Review for 10.1186/s12876-021-01730-8 (2021)

Reviewer’s report
Title: 
Gastrointestinal symptoms as first remarkable signs of ANCA-associated
granulomatosis with polyangiitis: case report and review
Version: 
1 
Date: 
09 Mar 2021
Reviewer's report:
"PEER REVIEWER ASSESSMENTS: 
OBJECTIVE - Full research articles: is there a clear objective that addresses one
or several testable research questions? (Brief or other article types: is there a
clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols)
appropriate for the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient
technical rigor to allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
N/A - there are no statistics in this study
INTERPRETATION - Is the current interpretation/discussion of the results
reasonable and not overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your
concerns sufficiently for you to now recommend the work as a technically sound
contribution? If not, can further revisions be made to make the work technically
sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS: 
GENERAL COMMENTS: This is an interesting manuscript describing GI
symptoms as a first presenting sign of ANA-associated vasculitis. This is an
important topic, and a finding that is often understated in the literature. As the
reviewers have noted, the hematuria was likely the true ""initial"" presenting
sign of ANCA-vasculitis, but I do not think this detracts from the importance of
the case/review. Ultimately, the authors are demonstrating severe GI disease as a
preceding event to florid ANCA vasculitis. Whether minor symptoms were first
is a matter of debate, but this article raises awareness of severe GI
manifestations.
REQUESTED REVISIONS: 
Few small English errors. "He leaved the hospital after 10 153 days of
observation" should be 'he left'. The major premise of the report and review is
sound."
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