Review for 10.1186/s12876-022-02102-6 (2022)

Reviewer’s report
Title: 
Malignant rhabdoid tumor of the liver in a middle-aged woman: a case
report and literature review
Version: 
1 
Date: 
08 Jun 2021
Reviewer: 
Helen Reeves
Reviewer's report:
This is an interesting case report of a woman presenting with a rare primary liver
tumour. 
The case is well presented and the shortcomings of available therapies
very clearly discussed. 
The authors also review recent molecular characterisation
of the tumour, with deletion of SMARCB1 the focus. 
They go on to give an
overview of SMARCB1-related signal transduction and potential therapeutic
targets, which may have clinical relevance. 
This was very interesting. The
images of scans and histopathology are also good.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
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from apparent manipulation?
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