Review for 10.1186/s12876-021-01645-4 (2021)

Reviewer’s report
Title: 
Polygenic Risk Score is a Predictor of Adenomatous Polyps at Screening
Colonoscopy
Version: 
1 
Date: 
20 Jan 2021
Reviewer: 
Shahram Agah
Reviewer's report:
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Thank you for your interesting research with good written text.
There are only a few concern which should be answered more than previus
concerns with the other reviewers. Could you please answer them ?
1. As I am informed, the population of Illinois is multicultural. However, you
have just included Caucasians in this study. Don't you think it could be a
selection bias?
2. "The mean and 95% confidence interval (CI) age at first screening" Do you
think that CI is meaningful regarding age of participant with and without
adenoma statistically ?
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
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Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
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