Review for 10.1186/s12876-021-01882-7 (2021)

Reviewer’s report
Title: 
Gastric amyloidosis presenting as acute upper gastrointestinal bleeding: a
case report
Version: 
2 
Date: 
26 Apr 2021
Reviewer's report:
In this report, the case of a patient with upper GI bleeding from a cardia
ulcerative lesion mimicking malignancy and ultimately diagnosed as amyloidosis
in multiple myeloma was reported. Some data of literature on amyloidosis were
discussed.
COMMENTS. 
* The therapeutic approach with embolization the left gastric artery is at least
questionable when considering the provided endoscopic picture of gastric cardia
lesion (Figure 1). Indeed, lacking of portal hypertension signs at CT scan denied
the suspicion of gastric fundic varices. Therefore, the incautious approach with
embolization (which was complicated pulmonary embolism and, probably,
duodenal ulcer) should be opportunely highlighted and discussed.
* Discussion was mainly focused on multiple myeloma and amyloidosis
management. According to my opinion, a systematic review of literature on
gastric amyloidosis should be performed in order to render appealing the case
report for a gastroenterological point of view. 
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