Review for 10.1186/s12876-018-0753-7 (2018)

Reviewer’ s report
Title: Symptoms and Diagnostic criteria of Acquired Megacolon - A systematic literature review
Version: 0Date: 30 Dec 2017
Reviewer: Ivano Biviano
Reviewer's report:
The study is a good tentative to better define acquired megacolon in the absence of organic
disease. In literature they well designed studies are missing. The authors evaluate case series,cohort and case reports studies and in many of these the sample size was small, and the studieswere heterogeneous. In this condition is not possible to define conclusive diagnostic criteria, butthis systematic literature review may be an initial way to better describe this condition.
Are the methods appropriate and well described?
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YesDoes the work include the necessary controls?
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YesAre the conclusions drawn adequately supported by the data shown?
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YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
Not relevant to this manuscriptQuality of written English
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AcceptableDeclaration of competing interests
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