Review for 10.1186/s12876-023-02695-6 (2023)

Reviewer’s report
Title: 
Potential utility of a multi-component coagulation factor panel to calculate
MELD scores and assess the risk of portal vein thrombosis in chronic liver
disease
Version: 
0 
Date: 
07 Nov 2022
Reviewer: 
Shahinul Alam
Reviewer's report:
The study seems to be very much appreciating to innovate a new prediction
score for PV thrombosis and replace role PT/INR by coagulation factor in
MELD score.
PVT increase morbidity and mortality in cirrhosis even without HCC. 
1. This background knowledge well described.
2.Knowledge gap is also described in 2nd para but here underestimated the role
of portal hypertension in thrombogenesis.
3. In aim they also described to develop a new formula to replace PT/INR by
Factor 5 and 8 though this in not relevant to title of the study. May change the
title.
Methodology:
4. It was a prospective cohort study for 6 months two separate centre but Follow-
up period seems very short to predict PV thrombosis. 
5. Again they ignore to measure potal HTN severity, diameter of portal vein ,
portal blood flow velocity, spleen length which have shown to have more
significant for PV thrombosis rather hypercoagulable state published in 5 years
follow-up of a prospective study published in Journal of Hepatology (Turon et
al. 2021 Predicting Portal vein thrombosis: A prospective study of clinical,
ultrasonographic and hemostatic factors).
6. Very small sample size.
Result
7. In Figure 2 and also in Table 2 it is found asTF gradually reduced with
severity of liver CTP score but during description they mentioned it was
elevated.
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