Review for 10.1186/s12876-020-01578-4 (2021)

Reviewer’s report
Title: 
Central lymph node metastasis is predictive of survival in advanced
gastric cancer patients treated with D2 lymphadenectomy
Version: 
0 
Date: 
07 Nov 2020
Reviewer's report:
The authors demonstrated the prognostic impact of central lymph node
metastasis in patients with gastric cancer undergoing gastrectomy with D2
lymphadenectomy. There are some queries and comments.
Comments
1) The present study was approved by the Institutional Review Board of the
Ethics Committee. The approval number should be indicated.
2) According to Table 3, adjuvant chemotherapy was selected as an independent
prognostic factor in multivariate analysis. How many patients received adjuvant
chemotherapy?
3) The clinical indication and regimens of adjuvant chemotherapy should be
indicated.
4) Ikoma et al. already reported the clinical significance of central lymph node
metastasis in patients with gastric cancer. This study seems to lack the novelty.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
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