Review for 10.1186/s12876-022-02111-5 (2022)

Reviewer’s report
Title: 
Nonthyroidal illness syndrome in acute pancreatitis patients: an 8-year
cohort study
Version: 
0 
Date: 
07 Mar 2021
Reviewer's report:
This manuscript described the incidence of NTIS in AP and revealed that FT3 is
a potential biomarker in the prediction of death in AP patients. Although the
manuscript presents interesting results, there are quite a few concerns regarding
its current form.
1.What is the reason for the upper limit of 70 years old in the exclusion criteria?
Why not take 80 years old as the upper limit.
2.Fig 1please verify that the FT3 and TSH trend are correct in LT3s+Low
TSH, Subclinical hypothyroidism and Subclinical hyperthyroidism.
3.Fig 3in the calculation of ROC curve, the percentage of dead patients in the
total included was not enough.
4.The discussion should explain why FT3 is more effective as a predictor of
death in AP patients than other indicators such as CRPWBC and Alb.
This are just overall points that weaken the paper that no conclusion can be
drawn. The logic is still there.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
No
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
No