Review for 10.1186/s12876-021-01847-w (2021)

Reviewer’s report
Title: 
Gastrointestinal Manifestations of Synthetic Cannabinoids: A
retrospective cohort study
Version: 
2 
Date: 
31 Mar 2021
Reviewer's report:
PEER REVIEWER ASSESSMENTS: 
OBJECTIVE - Full research articles: is there a clear objective that addresses one
or several testable research questions? (Brief or other article types: is there a
clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols)
appropriate for the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient
technical rigor to allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results
reasonable and not overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your
concerns sufficiently for you to now recommend the work as a technically sound
contribution? If not, can further revisions be made to make the work technically
sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS: 
GENERAL COMMENTS: HAVE THE AUTHORS RESPONDED
ADEQUATELY TO EACH OF THE QUESTIONS YOU 
> RAISED IN YOUR COMMENTS It appears that the authors did respond to
my review
> 
> 
> HAVE THEY MADE THE APPROPRIATE CHANGES IN THE
MANUSCRIPT 
Unfortunately I did not get a copy of the authors' responses to my previous
review. 
> I did , however, see the text with the changes highlighted. I have read the
entire manuscript again
I think that they certainly did make the appropriate changes to stay speculative
on the role of SC in intestinal ischemia via vasospasm 
> 
> 
> WHAT IS YOUR OVERALL IMPRESSION OF THE REVISED
MANUSCRIPT 
I am very supportive of this manuscript,
I think the authors have been careful to describe their patient group , have not
made 
old speculations of etiology of the symptoms , but DO raise the question of
the potential effects of SC on intestinal arterial flow and the possibility/question
of vasospasm- their transient marked increases in serum lactate levels in some of
these patients certainly is consistent 
with this possibility and needs to be studies
further.
GREAT JOB AUTHORS!
REQUESTED REVISIONS: 
authors please note these suggestions 
are all minor 
1. Page 5 line 32 please round off the 85.7% you only have 21 patients and
similarly with all the percentages thereafter ( you did round off all 
the others and in the table you just missed these
2. Page 5 line 42 after the word "shock" I would suggest that you say 
"see
below" 
3. Page 6 line 23 I did not see a table 2
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