Review for 10.1186/s12876-022-02220-1 (2022)

Reviewer’s report
Title: 
The role of faecal calprotectin in diagnosis and staging of colorectal
neoplasia: A systematic review and meta-analysis
Version: 
0 
Date: 
20 Nov 2021
Reviewer's report:
The authors performed a detailed meta-analysis on the subject of faecal
calprotectin (PC) as a noninvasive screening for early and advanced colorectal
adenomas, as colorectal carcinoma (CRC) as well as determination of its utility
in CRC staging. The study selection is detailed and unbiased. The exclusionary
criteria are rationally discussed, and efforts to unify reporting metrics, while not
perfect, is acceptable for analyses spanning many years, countries, and testing
platforms. The conclusion is appropriate and the discussion within the strength
of data presented. 
Nothing to add, other than potential editorial review of style:
for example would some of the material in the results section be better under
materials and methods? There seems to be efforts to describe methodology as
part of the result in some instances.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes