Review for 10.1186/s12876-018-0746-6 (2018)

Reviewer ’s report  
 
Title: Therapeutic preferences and outcomes in newly diagnosed patien ts with Crohn's disease in  
the biological era in Hungary. A nationwide study based on the National Health Insurance Fund  
database  
 
Version: 1 Date: 02 Jan 2018  
 
Reviewer: Julajak Limsrivilai  
 
Reviewer's report:  
 
Thank you for addressing my comment. I agree with the authors. However, I would like the 
authors to discuss in more detail why earlier introduction of  immunomodulators and biologics 
did not decrease surgical rate in this study. Could it be that the magnitude of differences of 
biologics/immunomodulators use in the 2 cohorts was not big enough, particularly in the first 
year after diagnosis? Or due to the  limitation of administrative databases that do not have the 
detail of disease severity and phenotype which could have affected the treatment outcome as the 
authors state in the limitation of the study?   
 
Are the me thods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscr ipt: 
 
Acceptable  
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursemen ts, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
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2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an org anization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all o f the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
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on my report to the authors and, if the manuscript is accepted for publication, my named report  
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I agree to the open peer review policy of the journal