Review for 10.1186/s12876-021-01996-y (2021)

Reviewer’s report
Title: 
Focal IgG4-related autoimmune pancreatitis with distal choledochal
adenocarcinoma: a rare case report
Version: 
0 
Date: 
03 Oct 2021
Reviewer's report:
This is an interesting paper on a rare but significant case. Please add "distal" to
choledocus in the title. Please provide more data on histology and images
demonstrating without doubts the clear origin of the neoplasia from the biliary
duct, such as biliary neoplasia. Please specify the presence of PanIN in the
sorrounding pancreatic parenchyma, as well as the status of the major papilla.
The authors should document extensively laboratory / blood exams values
including plasmacells, IgG4, amylase, C-reactive protein, VES, and others.
Please specify steroid treatment and clinical course. Please add
immunohistochemical staining used for diagnostic purposes.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
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Yes
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from apparent manipulation?
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