Review for 10.1186/s12876-020-01287-y (2020)

Reviewer ’s report  
 
Title: Exosomal miRNA signatures of pancreatic lesions  
 
Version: 1 Date: 21 Nov 2019  
 
Reviewer: Zhang Taiping  
 
Reviewer's report:  
 
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The article focused on the diagnostic efficacy of exosomal miRNAs on pancreatic lesions such as 
PDAC, pNET, IPMN and AVC. The research was up -to-date because the diagnostic research of 
exosomal miRNAs was the hotspot and the diagnosis of pancreatic lesion, which still remains a 
challenge.  
First of all, I would like to congratulate you that your research is innovative. However, there are 
still some issues that need to be noted:  
1. The background part of the article can be simplified, especially the introduction of 
different pancreatic lesions.  
2. The article didn't mention the AUC curve of the exosomal miRNA signature for 
pancreatic lesions diagnosis.  
3. The article didn't compare the diagnostic efficacy of exosomal miRNA with CA -199, a 
biomarker widely applied for the diagnosis of pancreatic cancer.  
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
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