Review for 10.1186/s12876-020-01507-5 (2020)

Reviewer’s report
Title: 
Small intestinal mucosal injury and its risk factors in patients with
gastrointestinal cancer who developed complicated fluoropyrimidine-induced
diarrhea
Version: 
2 
Date: 
19 May 2020
Reviewer's report:
The authors aim to report capsule endoscopy findings of patients with
complicated fluoropyrimidine-induced diarrhea. The authors stated that the study
has been the first study to evaluate the entire small intestine of patients with CID
using CE in discussion. However, there are several reports are published to
evaluate the patients with CID using CE (ex, Scand J Gastroenterol.
2019;54:227-232.). I recommend for authors to add the additional analysis to the
manuscript. Please see below.
Major point
Because the study is evaluated for small intestinal injury in only 12 patients with
complicated CID, readers do not understand the degree of association between
severity of small intestinal injury and complicated CID. The manuscript will be
improved to add (ex.) the analysis in capsule endoscopy findings between 12
patients with complicated CID and 12 background matched patients with
fluoropyrimidine chemotherapy without diarrhea.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the
authors.
Unable to assess
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
No
Are you able to assess any statistics in the manuscript or would you
recommend an additional statistical review?
If an additional statistical review is recommended, please specify what aspects
require further assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Acceptable
Declaration of competing interests
Please complete a declaration of competing interests, considering the following
questions:
1
. 
Have you in the past five years received reimbursements, fees, funding, or
salary from an organisation that may in any way gain or lose financially
from the publication of this manuscript, either now or in the future?
2
. 
Do you hold any stocks or shares in an organisation that may in any way
gain or lose financially from the publication of this manuscript, either now
or in the future?
3
. 
Do you hold or are you currently applying for any patents relating to the
content of the manuscript?
4
. 
Have you received reimbursements, fees, funding, or salary from an
organization that holds or has applied for patents relating to the content of
the manuscript?
5
. 
Do you have any other financial competing interests?
6
. 
Do you have any non-financial competing interests in relation to this
paper?
If you can answer no to all of the above, write 'I declare that I have no competing
interests' below. If your reply is yes to any, please give details below.
I declare that I have no competing interests'
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