Review for 10.1186/s12876-016-0493-5 (2016)

Reviewer ’s report  
 
Title: Poly(ADP -ribose) polymerase inhibition suppresses inflammation and promotes recovery  
from adrenal injury in a rat model of acute necrotizing pancreatitis  
 
Version: 0 Date: 25 Mar 2016  
 
Reviewer: John H. Winston  
 
Reviewer's report:  
 
This study shows that treatment with the PARP inhibitor, 3-AB, significantly reduced pancreatic 
inflammation and adrenal injury in a rat model of acute necrotizing pancreatitis.  These findings 
were associated with increased adrenal function and survival of 3 -AB treated rats.   
 
 
Data are solid and support autho r's conclusions.  
 
Figure  3 Are H and G switched?  
Figure 3 Legend: Is F 3 -AB treated or is it ANP 6 hours?  
 
Figure 6C: define TBP  
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors . 
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the aut hors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your c omments to the editors.  
 
I am able to assess the statistics  
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
 
 
 
Declaration of competing interests  
Please complete a declaration of competing interests, conside ring the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
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2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  
If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
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I agree to the open peer review policy of the journal