Review for 10.1186/s12876-016-0434-3 (2016)

Reviewer ’s report  
 
Title: Effect of Coexisting Diabetes Mellitus and Chronic Kidney Disease  on Mortality of 
Cirrhotic Patients with Esophageal Variceal Bleeding  
 
 
Version: 0 Date: 23 Sep 2015  
 
 
Reviewer: Vincenzo  La Mura  
 
 
Reviewer's report:  
 
Interesting topic. Few criticisms:  
 
1-Author should differentiate for the etiology of CKD  
 
2-Authors found that HBV infection was associated with a higher risk of mortality ( see 
Table 1). This is reported in Table 1 but not in the main text of the manuscript. In 
addition, this would need, in my opinion, a specific comment.  
 
3-The article by Persico et al World Journal of Gastroenterology 2009 and Petta et al 
Hepatology 2009 cou ld be quoted in the reference list to reinforce the message that 
cirrhosis, per se, independently by the viral etiology, may be associated with the 
development of insulin resistance and diabetes  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn ade quately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical  review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
I recommend additional statistical review  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five y ears received reimbursements, fees, funding, or salary from 
an organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may i n any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial com peting interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
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