Review for 10.1186/s12876-018-0789-8 (2018)

Reviewer ’s report  
Title: Thrombin and Factor Xa Link the Coagulation System with Liver Fibrosis  
 
Version: 3 Date: 12 Mar 2018  
 
Reviewer: Thierry Hauet  
 
Reviewer's report:  
I would like to thank the authors for adding some clarifications.  
I just have minor comments on Figure 1 I -K:  
 
- My previous comment on the relative gene expression of collagen, alpha -SMA and TGF -beta 
seems to not have been understood correctly. As the re lative gene expression levels in groups 
Thr alone and FXa alone were close to one, it seemed that there was no difference with control 
group. However, it is clear that the combination of Thr and FXa increases the relative 
expression of these three genes.  
 
- The scale is not noticeable any more.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
Yes 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
Yes 
Are the conclusions drawn adequately supporte d by the data shown?  
If not, please explain in your comments to the authors.  
Yes 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please spe cify what aspects require further 
assessment in your comments to the editors.  
I am able to assess the statistics  
Quality of written English  
Please indicate the quality of language in the manuscript:  
Acceptable  
Declaration of competing interests  
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