Review for 10.1186/s12876-021-01849-8 (2021)

Reviewer’s report
Title: 
Small intestinal follicular lymphoma induced by methotrexate: A case
report
Version: 
0 
Date: 
23 Apr 2021
Reviewer: 
Jobin Philipose
Reviewer's report:
First of all congratulations on writing a comprehensive case report. Please see
the comments below
Please say in case report if patient was having Bowel movement or passing gas,
vomiting abdominal distension. Did CT show any signs of obstruction?
Was patient have any weight loss, how severe were the symptoms that we
decided to evaluate small bowel.
Abdominal plain computed, tomography (CT), esophagogastroduodenoscopy,
and total colonoscopy: Please say if CT scan was contrast study?. Also say
ileocolonoscopy and not total colonoscopy. Was TI intubated and showed any
ulcers or pathology?
Earlier was said normal CT abdomen and then says small bowel thickening.
Please explain.
We conducted a small bowel examination. (Please remove this sentence)
Prior to examination with a small bowel capsule endoscope, patency, capsule
examination was performed. (Was capsule endoscopy performed, it only says
anal endoscopy and oral balloon endoscopy.
First, a transanal balloon endoscopy showed no abnormal findings such as
ulcerative lesions or stenosis. We performed carbon ink injection on the deepest
anal part. (Please write no ulcerative lesion where? Example small intestine don't
use anal part.
Please discuss the possibility that it is also possible that this lymphoma is not
associated with MTX. As some major studies have reported no statistical
significance with MTX and LPD. (Lymphoma in rheumatoid arthritis: the effect
of methotrexate and anti-tumor necrosis factor therapy in 18,572 patients)
Also, some studies have reported no association with Non Hodgkins Lymphoma
(Mariette X, Cazals-Hatem D, Warszawki J, Liote F, Balandraud N, Sibilia J,
Investigators of the Club Rhumatismes et Inflammation Blood.
2002;99(11):3909.
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