Review for 10.1186/s12876-020-01285-0 (2020)

Reviewer ’s report  
 
Title: Colonic transendoscopic tube -delivered enteral therapy (with video): A prospective study  
 
Version: 0 Date: 14 Sep 2019  
 
Reviewer: Gianluca Ianiro  
 
Reviewer's report:  
 
INTRODUCTION  
 
- FMT has evidence also in irritable bowel syndrome. Please add it to the other indications you 
listed. You could use this recent metanalysis as reference 
(https://www.ncbi.nlm.nih.gov/pubmed/3 1136009)  
 
- Oral FMT capsules open in the mid gut, so please correct.  
 
- Please remove drinking FMT among the administration routes  
 
- Agree that single FMT could be not enough, especially in patients with severe CDI: several 
papers have shown it, please cit e them: https://www.ncbi.nlm.nih.gov/pubmed/29851107; 
https://www.ncbi.nlm.nih.gov/pubmed/28057560; 
https://www.ncbi.nlm.nih.gov/pubmed/26096320  
 
- Agree that colonic route has higher efficacy. This has been shown in a metanalysis, that should 
be cited to s upport this sentence: https://www.ncbi.nlm.nih.gov/pubmed/30288286  
 
- please avoid the term real world and change with real -life 
 
 
METHODS  
 
This is a prospective or a retrospective study?  
 
 
RESULTS  
 
Which were the indications for FMT through TET? You should div ide efficacy and safety 
results, as well as uni - and multivariate analysis, for different indications, and discuss results in 
the discussion. Otherwise the paper could not be accepted to me  
 
Did you use this tool also in severe UC/CDI? If yes, which were sa fety outcomes (especially in 
putting a clip on a fragile mucosa)  
 
 
OVERALL  
 
Need for extensive English editing.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls a re required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the qu ality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1.  Have you in the past five years rec eived reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the future?  
 
2.  Do you hold any stocks or shares in an organisation that may in any wa y gain or 
lose financially from the publication of this manuscript, either now or in the 
future?  
 
3.  Do you hold or are you currently applying for any patents  relating to the content 
of the manuscript?  
 
4.  Have you received reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
none  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
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to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal