Review for 10.1186/s12876-021-01814-5 (2021)

Reviewer’s report
Title: 
Co-occurrence of Wilson's disease and systemic lupus erythematosus: a
case report and review of literature
Version: 
0 
Date: 
30 Nov 2020
Reviewer's report:
This is an interesting case report in a patient diagnosed with SLE who was later
diagnosed with Wilson Disease. The result is a bit of a turnabout on prior reports
where penicillamine treatment for Wilson Disease appeared to precipitate or
precede diagnosis of SLE. The report is thorough, presents possible alternative
explanations though might benefit from a deeper exploration of relevant
literature. A few comments to that end are included below. 
It might be useful to report a Leipzig score for WD. I think the patient would fall
between 7 and 11 depending on missing data that is filled in. 
Page 5, line 56 (or 109) should have a reference for guidelines (possible
reference: European Association for Study of Liver. EASL Clinical Practice
Guidelines: Wilson's disease. J Hepatol. 2012 Mar;56(3):671-85. doi:
10.1016/j.jhep.2011.11.007. PMID: 22340672.)
Walshe's paper on penicillamine treatment and SLE is not correctly cited:
(reference 17). This work found that several Wilson Disease patients treated with
penicillamine had developed serologic SLE and discontinued treatment while
others developed immune complex nephritis. 
This study may be interesting to mention:
Dell'era L, Boati E, Nebbia G, Corona F. Wilson's disease treated with
penicillamine and lupus erythematosus: related or distinct entities? Minerva
Pediatr. 2012 Feb;64(1):55-7. PMID: 22350045.
Pedigrees and case reports indicate that Endemic Infantile Tyrolean Cirrhosis (as
ICC and ICT) are gene-environment interaction: Muller T, Feichtinger H, Berger
H, Muller W. Endemic Tyrolean infantile cirrhosis: an ecogenetic disorder.
Lancet. 1996 Mar 30;347(9005):877-80. doi: 10.1016/s0140-6736(96)91351-3.
PMID: 8622397.
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