Review for 10.1186/s12876-021-01803-8 (2021)

Reviewer’s report
Title: 
Anti-IL-4Ralpha monoclonal antibody dupilumab mimics ulcerative colitis: A case report
Version: 
0 
Date: 
10 Mar 2021
Reviewer's report:
I read with interest this first report of a young patient who developed ulcerative colitis (UC) during
treatment with dupilumab, an anti-IL4R used for treatment of atopic dermatitis. 
There are some issues which should be clarified before publication:
- patient weight and dupilumab dosage should be specified;
- the total follow-up period should be reported;
- the discussion section should be better organized: please, clarify which is the exact mechanism of action
of dupilumab; also, it is not clear the role of IL-17 (mentioned in the discussion) in the cytokine pathways
modulated by dupilumab. A figure explaining these mechanisms would add significant value to this case
report. 
- Figures: I suggest to create a figure 1 including one endoscopic image (rectum) as figure 1A, together
with the histologic finding as figure 1B. Then a different figure 2, with cytokine and inflammatory
pathways influenced by dupilumab may be created and added. 
- reference n.15 is not enough detailed, because I could not find the data mentioned in the test. Could you
please better define it?
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Is the study design appropriate to answer the research question (including the use of appropriate controls),
and are the conclusions supported by the evidence presented?
No
Are the methods sufficiently described to allow the study to be repeated?
No
Is the use of statistics and treatment of uncertainties appropriate?
No
Is the presentation of the work clear?
No
Are the images in this manuscript (including electrophoretic gels and blots) free from apparent
manipulation?
Yes