Review for 10.1186/s12876-021-01899-y (2021)

Reviewer’s report
Title: 
Long-term prognosis after endoscopic submucosal dissection for
colorectal tumors in patients aged over 80 years
Version: 
0 
Date: 
19 May 2021
Reviewer's report:
This retrospective study evaluated the safety and efficacy of ESD for colorectal
tumors
in elderly patients aged over 80 years. They concluded that ESD for patients
aged over 80 years was safe and it prevented colorectal cancer-related deaths.
The study is based on a relatively large series and well-written, however this is
not original (the topic has been already evaluated) and does not add many new
data. There are comments as follows.
Comments
1. This study included the patients within the ASA-PS class 3. How about more
than class 4? If such patients are excluded, please comment the reason in the
method.
2. Regarding the outcomes of ESD, the authors had better show the hospital
stays, minor events (sedative drug induced events e.g. falling, delirium) during
hospitalization because incidental accidents sometime occur in the elderly
patients.
3. The title of table2 "endoscopic mucosal resection" was wrong. In addition,
progress after endoscopic submucosal resection" was also wrong. Please revise
them.
4. The authors should show the reasons why patients in non-curative resection
did not undergo the additional surgery. Patient's refusal? or poor ASA-PS?
Please discuss it.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes