Review for 10.1186/s12876-020-01488-5 (2020)

Reviewer’s report
Title: 
Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract: a
tricky diagnosis of a gastric case
Version: 
1 
Date: 
15 Sep 2020
Reviewer's report:
The authors illustrate and interesting case of ITLPD of the GI tract occurring in
the stomach of a young woman. The report is brief and overall well written and
illustrated. I have a few minor suggestions. 1) The language could be improved a
bit. Review by a native English speaker could 
help, 2) I am not aware of word
count constraints, but the the method used for TCR-g gene rearrangement should
be mentioned. You could state PCR analysis for TCR-g gene rearrangement was
performed according to the method of XYZ et al and provide the reference, 3)
This case occurred in a young woman and involved the stomach and bone
marrow. These points should be emphasized in the abstract and discussion, since
ITLPD generally is a disease of older adults, occurring in the intestines, and
dissemination to other organs has not been emphasized enough, 4) How s disease
excluded in other parts of the GI tract? Clearly imaging and scans are
insufficient. Should mention if other biopsies were reviewed and
immunohistochemistry and molecular analysis were performed , with the results.
This is important as disease infiltration can be subtle in other GI organs. If these
studies were not performed, at least TCR-g gene rearrangement analysis should
be performed on biopsies from other sites to rule out the possibility of wider
dissemination, 5) Lastly, there have been recent advances in understanding the
molecular abnormalities in ITLPDs, the authors could mention recurrent genetic
alterations briefly (one or two sentences) with the appropriate references.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
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No
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from apparent manipulation?
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