Review for 10.1186/s12876-022-02411-w (2022)

Reviewer’s report
Title: 
Study protocol of a single-arm phase 2 study evaluating the preventive
effect of topical hydrocortisone for capecitabine-induced hand-foot syndrome in
colorectal cancer patients receiving adjuvant chemotherapy with capecitabine
plus oxaliplatin (T-CRACC study)
Version: 
0 
Date: 
24 May 2022
Reviewer: 
Chihiro Kosugi
Reviewer's report:
This is a phase 2 study protocol paper that examines the efficacy of
hydrocortisone butyrate for suppressing HFS that develops during CAPEOX
therapy as adjuvant chemotherapy for colorectal cancer. Suppression of HFS is
still one of the adverse events that remains an issue, so I think it is a good clinical
trial. I look forward to the success of the trial.
1) In 'Intervention', it is written that hydrocortisone butyrate is applied twice a
day, but I think it is necessary to describe the amount and frequency of use per
time, so please describe it.
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