Review for 10.1186/s12876-022-02397-5 (2022)

Reviewer’s report
Title: 
Acute hepatitis B virus infection despite vaccination in a patient treated by
infliximab: a case report
Version: 
0 
Date: 
07 Mar 2022
Reviewer's report:
This study reports a patient treated by infliximab, who was diagnosed with an
active HBV infection, despite a correct immunization scheme against HBV prior
to immunosuppressive therapy. Low anti-HBs level and presence of the immune
escape mutation sD144A are possible factors for the occurrence of the infection.
Dual therapy combining tenofovir disoproxil fumarate and emtricitabine was
initiated and HBV functional cure was achieved ten months after treatment
initiation.
Since screening for hepatitis B before starting an immunosuppressive therapy is
widely recommended to prevent any risk of viral reactivation, it is surprising that
anti-HBc was not tested before the initiation of infliximab treatment. Authors
should describe which three markers for hepatitis B have to be tested before
starting an immunosuppressive treatment (page 6, line 136). 
I suggest an English proofreading of the text. There are some spelling and
grammar mistakes, as well sentences that can be rewritten, as such:
Line 28: Please replace "screening" by "screenings".
Line 31: This sentence should be rewritten. A suggestion would be "In addition,
HBV sequencing revealed a genotype A2 carrying the sD144A substitution on
the S protein, known as a potential immune escape variant."
Line 67: Please replace "HBc antibodies" by "anti-HBc Ab"
Line 72: carrying THE sD144A
Line 78: a decline… WAS recorded
Line 106: "Yet, and This was the case for…" This sentence should be formatted. 
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Is the study design appropriate to answer the research question (including the use
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