Review for 10.1186/s12876-022-02249-2 (2022)

Reviewer’s report
Title: 
A case of esophageal neuromuscular choristoma
Version: 
0 
Date: 
28 Jan 2022
Reviewer's report:
PEER REVIEWER ASSESSMENTS: 
RELEVANCE - Does this case report make a contribution to medical
knowledge, have educational value, or highlight the need for a change in clinical
practice or diagnostic/prognostic approaches? 
Yes, this report contributes to medical knowledge
CASE DESCRIPTION - Are the details of the case sufficiently well described to
understand the patient's symptoms and course of treatment? 
No - there are major issues
DIAGNOSIS/INTERPRETATION - Based on the facts presented, are the
diagnosis, interpretation, and course of treatment medically sound?
No, based on information contained in the report, the authors' interpretation of
this case is unsound
DISCUSSION OF THE CASE - Does the discussion appropriately analyse the
importance of the findings and their relevance to future understanding of disease
processes, diagnosis or treatment? Has an adequate literature review pertinent to
the case been included?
Yes, the case is discussed fully in the context of the literature
OVERALL MANUSCRIPT POTENTIAL - Could an appropriately REVISED
version of this work represent a technically sound contribution?
Maybe - with major revisions
PEER REVIEWER COMMENTS: 
GENERAL COMMENTS: This is the interesting case report of the firstly
reported neuromuscular choristoma arising in adult esophagus. However, I am
afraid to admit that this reviewer by no means agree with the diagnosis with
confidence unless histopathological findings of high power magnification would
be provided. If this is NMC, there would be no questions in publishing this
interesting case in terms of novelty.
REQUESTED REVISIONS: 
The authors must provide the histological illustrations with better resolution and
quality. Ultrasound and endoscopic illustrations are considered reasonably
excellent in terms of quality but histology and immunohistochemistry are
markedly poor in terms of quality. As mentioned, the authors must provide those
in high power magnification in both hematoxylin and eosin stain and
immunohistochemistry. In addition, the authors should also add
immunohistochemistry of Ki-67, NF or neuro-fillament and caldesmon.
ADDITIONAL REQUESTS/SUGGESTIONS: 
As previously mentioned, additional immunohistochemistry and replacement of
histology illustrations.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
No
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No
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Yes
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No
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes