Review for 10.1186/s12876-023-02696-5 (2023)

Reviewer’s report
Title: 
A novel capsule endoscopy for upper and mid-GI tract: the UMGI capsule
Version: 
1 
Date: 
01 Dec 2022
Reviewer's report:
This is an interesting, simple and nice pilot study about a novel upper and mid
gastrointestinal (UMGI) magnetically controlled capsule endoscopy device with
a detachable string (DS-MCE).
This study is valuable because generates interesting issues to be resolved in
future research.
The R1 manuscript has much improved, is concise and well written, data are
presented in a clear way, Discussion is consistent with the study data.
Therefore, I offer just a few suggestions that may be considered by the Authors
to improve the strength of the manuscript.
In my opinion the sentence "… especially in patients with GI bleeding and
taking antithrombotic or non-steroidal anti-inflammatory Drugs…" is misplaced
throughout the manuscript.
It is certainly true that patients presenting with GI bleeding and taking
antithrombotic therapy or who are on NSAIDS after a negative bi-directional
endoscopy will be candidates for a capsule endoscopy (e.g. the recent ESGE
VCE and DAE guideline, Endoscopy 2022 Nov 24. doi: 10.1055/a-1973-3796.
Online ahead of print), but the study was not about these cases.
The study did not specifically enroll patients based on these inclusion criteria,
therefore it will be more appropriate to state that the DS-MCE "might be
indicated" in cases of suspect upper and small bowel GI bleeding, possibly
associated with or due to the use of anticoagulant/antiplatelet therapy, use of
NAIDS…
The authors can certainly discuss the possible value of the DS-MCE in these
instances, and what is reported at page 4 ( lines 41-49) is correct, but the
affirmation that the DS-MCE is especially indicated in these cases should be
removed from the conclusions in the Abstract and in Discussion.
Page 4, line 8, consider removing the sentence "repeated endoscopy", the correct
flow suggested by e.g. the ESGE VCE and DAE guideline (that the authors
might not be aware of because published a few days ago) is to perform a small-
bowel capsule endoscopy as the next examination after a negative bi-directional
endoscopy.
Page 4, lines 1-10 and lines 41-49 are redundant, consider merging and
summarizing within a single sentence.
Declaration of competing interests
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes
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