Review for 10.1186/s12876-022-02406-7 (2022)

Reviewer’s report
Title: 
The impact of serum thyroid-stimulation hormone levels on the outcome
of hepatitis B virus related acute-on-chronic liver failure: an observational study
Version: 
3 
Date: 
22 Feb 2022
Reviewer's report:
Chen JF, et al. reported the association between transplant-free survival and
serum TSH levels in patients with hepatitis B-related ACLF. The revised
manuscript seems almost appropriate but following problem should be
considered before publication.
Comment
Why the authors determined the cut-off value in serum TSH level based on the
tertiles? AUROC analysis might demonstrate most appropriate cut-off value
predicting patients' survival. Please discuss about this point.
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