Review for 10.1186/s12876-018-0865-0 (2018)

Reviewer ’s report  
Title: Pancreas grafts for transplantation from donors with h ypertension: An analysis of the 
Scientific Registry of Transplant Recipients database  
 
Version: 2 Date: 26 Jun 2018  
 
Reviewer: Cristina Silvestre  
 
Reviewer's report:  
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Background: line 4 "It has been ac cepted diffusely that pancreas transplantation could be a 
considerable alternative to continued insulin therapy..." also islet transplantation is a good option 
for patients with type 1 diabetes; islet transplantation has become increasingly safe and effect ive 
in stabilizing glycemic control in long -term, normalizing HbA1c and lowering the risk of 
secondary complications in patients with type 1 diabetes. Recent advances in islet transplantation 
have markedly improved the 5 -year insulin independence rates, wh ich in several independent 
centers is reported around 50%, placing islet transplantation, on a par with vascularized pancreas 
transplant alone.  
I do believe the authors sholud mention this therapeutic option at some point in the background 
of the paper.  
 
Table 1: Donors characteristics like ICU stay; Cardiac arrest; Serum Creatinine and Estimated 
GFR, Vasopressor use: should be describe in the table and in the paper.  
 
The description of the results should be improved for example with a table that showing: cause 
of death of the patient, cause of graft loss, surgical complications etc. in the two groups  
 
Background: page 4 line 1: cadaveric donor should be replaced with d eceased  
Background: page 4 line 5:"effect impressed on": correct  
 
Are the methods appropriate and well described?  
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Yes 
Does the work include the necessary controls?  
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Yes 
Are the conclusions drawn adequately supported  by the data shown?  
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No 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
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assessment in your comments to the editors.  
I am able to assess the statistics  
Quality of written English  
Please indicate the quality of language in the manuscript:  
Acceptable  
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