Review for 10.1186/s12876-016-0474-8 (2016)

Reviewer ’s report  
 
Title: Prognostic significance of synergistic hexokinase -2 and beta2 -adrenergic receptor 
expression in human hepatocelluar carcinoma after curative resection  
 
 
Version: 0 Date: 17 Nov 2015  
 
 
Reviewer: Weihua  Gong  
 
 
Reviewer's report:  
 
Well done!  
 
The statistics may be not very good. In table 2. the p value of "tumor size " and "TNM stage" is 
0.001, which means the two group is different at base line. So when you later analyse the 
statistics, it makes your ration less powerful. So I recommend more cases included or any other 
methods to deplete the difference.  
 
I am afraid th at in line 44 "later" should be "latter".  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
No 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the ma nuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees,  funding, or salary from 
an organisation that may in any way gain or lose financially from the publication of this  
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2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial com peting interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests'  
 
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