Review for 10.1186/s12876-021-01686-9 (2021)

Reviewer’s report
Title: 
Ectopic pancreas 
appearing as a giant gastric cyst mimicking gastric
lymphangioma: a case report and a brief review
Version: 
0 
Date: 
30 May 2020
Reviewer's report:
This is a simple case report of ectopic pancreas presented as a large gastric cystic
lesion and appears to be well-written. However, a few points need to be re-
considered. 
1. The cystic lesion described as a large, submucosal well-demarcated lesion
with heterogeneous solid and cystic components. although lymphangioma could
be one of the differential diagnosis, i don't see any specific features to really
favor lymphangioma over other benign cystic lesions. Also, lymphangioma
usually also involves mucosa, rather than a submucosal lesion. CT impression
should be considered, but needs to correlate clinically. 
2. page 4 line 10, "cystic lesion lined by .... cubic serous epithelium .... " is NOT
enough to make the diagnosis of serous cystic adenoma or noeplasm (SCA).
Also, the Fig3g microscopic image, although not clear enough, the pinkish
(protenaceous) cystic content suggestive of retention cyst. To confirm it's a true
SCA, you need to show the cuboidal lining cells contain glycogen (PAS/PASD
stain), or stain with Inhibin, or show it has VHL mutation. Otherwise, all the
discussion regarding SCA need to be changed. 
3. page 5, line 44, "nonneoplastic cyst includes SCA...), i think SCA is a
neoplastic cyst characterized by VHL mutation and accumulated somatic
mutation (see Hopkins paper on somatic mutation in various pancreastic
tumor/cysts). In addition, SCA can progress or metastasize (the so-called serous
cystic adenocarcinoma). 
Are the methods appropriate and well described?
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Yes
Does the work include the necessary controls?
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authors.
Unable to assess
Are the conclusions drawn adequately supported by the data shown?
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Unable to assess
Are you able to assess any statistics in the manuscript or would you
recommend an additional statistical review?
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require further assessment in your comments to the editors.
Not relevant to this manuscript
Quality of written English
Please indicate the quality of language in the manuscript:
Acceptable
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