Review for 10.1186/s12876-017-0680-z (2017)

Reviewer ’s report  
 
Title: Fast food diet -induced non -alcoholic fatty liver disease exerts early protective effect 
against acetaminophen intoxication in mice  
 
Version: 0 Date: 02 Sep 2017  
 
Reviewer: Giuseppe Fanelli  
 
Reviewer's report:  
 
The study is very innovative an d well written, but I have some minor concerns:  
Which kind of grading and staging system have been used for scoring NAFLD/NASH? What 
results were achieved?  
It would be better to include in the study the numerical difference between mice with NAFLD 
and mice  with NASH (if present), and eventually their difference in APAP -induced ALI.  
Thank  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you re commend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indic ate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, fundin g, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
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2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from th e publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
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