Review for 10.1186/s12876-017-0736-0 (2018)

Reviewer ’s report  
 
Title: Safety, tolerability and pharmacodynamics of apical sodium -dependent bile acid 
transporter inhibition with volixibat in healthy adults and patients with type 2 diabetes mellitus: a 
randomised placebo -controlled trial  
 
Version: 1 Date: 10 Dec 2017  
 
Reviewer: Cristiane Villela -Nogueira  
 
Reviewer's report:  
 
The authors made modifications in methods session that improved the article and clarified its 
methodology.  
Discussion  is well performed as well.  
Tables are clear and show the results of the study ad equately.  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in t he manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five year s received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in a ny way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding , or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you  can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
'I declare that I have no competing interests'  
 
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on my report to the authors and, if the manuscript is accepted for publication, my named report  
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