Review for 10.1186/s12876-020-01481-y (2020)

Reviewer’ s report
Title: Tuberous Sclerosis Complex with rare associated findings in the gastrointestinal system: a
case report and review of the literature.
Version: 1Date: 28 Aug 2020
Reviewer: Helga Bertani
Reviewer's report:
The authors report a case of an unusual association between TSC and multiple GI manifestations
(pNET, gastric and colonic polyps).pNET has recently been described in a rare germline pathogenetic variant in TSC2 but theinteresting point is that no previous reports of a relation between tubular adenomatous polyposis instomach and colon and TSC have been reported before.The only suggestion for authors is to stress in the discussion the possibile relation with germlinevariation in consideration of the number of gastric and colonic lesions, unusual for sporadicpolyps.Moreover glandular funds polyps and tubular adenomatous polyps could be the two differentexpressions of the same germline variation.
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Is the study design appropriate to answer the research question (including the use of appropriate
controls), and are the conclusions supported by the evidence presented?
YesAre the methods sufficiently described to allow the study to be repeated?YesIs the use of statistics and treatment of uncertainties appropriate?YesIs the presentation of the work clear?Yes
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