Review for 10.1186/s12876-021-01900-8 (2021)

Reviewer’s report
Title: 
TPMT and NUDT15 polymorphisms in thiopurine induced leucopenia in
inflammatory bowel disease: A prospective study from India
Version: 
0 
Date: 
11 Jun 2021
Reviewer's report:
- There are possible factors associated with leukopenia in IBD, eg. concomitant
autoimmune/liver disease, severity/activity of disease, other medication (steroid,
biologics) which may included in result, table 1 and analysis.
- Titration of AZA to 2.5 mk/kg ot 6MP to 1 mg/kg were routinely performed in
all cases, despite of clinical remission ot improving ?
- Please clearly define about idiosyncratic reaction definition in the study
- Some parameter may be no normal distribution or high SD, consider for using
median, IQR.
- Please discuss about NUDT15 and thiopurine in IBD vs. non-IBD setting.
- Please update or compare the result with recent literature (NUDT15 in IBD)
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