Review for 10.1186/s12876-020-01559-7 (2020)

Reviewer’s report
Title: 
Immunoglobulin G4-associated autoimmune hepatitis with peripheral
blood eosinophilia: a case report.
Version: 
0 
Date: 
26 Jun 2020
Reviewer's report:
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This case report describes a patient with IgG4-related autoimmune hepatitis with
peripheral blood eosinophilia. Although it is well written, the following points
should be addressed to improve the content. 
1. Absolute eosinophil count in the blood is very high (2,592 cells/
μ
L) in this
case, and eosinophilic granulomatosis with polyangiitis (EGPA) is an important
differential diagnosis. No elevation of serum C-reactive protein (CRP) level and
the absence of anti-neutrophil cytoplasmic antibodies (ANCA) would be very
helpful to rule out EGPA.
2. Similarly, the absence of mononeuropathy and histopathological granuloma or
necrotizing vasculitis would help make the diagnosis of IgG4-related disease
(IgG4-RD) rather than EGPA. The authors should note these points in the case
section.
3. Since IgG4-RD is sometimes accompanied by allergic disease such as
bronchial asthma or allergic rhinitis, the presence/absence of allergic diseases in
this patient would be very important and should be noted in the past or present
history.
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