Review for 10.1186/s12876-016-0501-9 (2016)

Reviewer ’s report  
Title : Clinical efficacy of adalimumab in Crohn's disease: a real practice observational study in 
Japan  
 
Version:  1 Date:  27 Mar 2016  
 
Reviewer:  Quais  Mujawar  
 
Reviewer's rep ort: 
This is a very well thought and planned study which fills in the gaps of our knowledge from 
Asia. The results reached have an impact on everyday clinical practice. Furthermore it is well 
written with suitable tabl es and illustrations, and the conclusion reached is suitable.  
1) Consider putting up a study Flow Diagram for ease of understanding  
2) Consider describing methods of data collection .Is this is a chart review/record review?  
3) Please consider using sep arate headings study inclusion, exclusion criteria, method of data 
collection, outcomes measured etc.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
No 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments t o the authors.  
Yes 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
Yes 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
I recommend additional statistical review  
Quality of written English  
Please indicate the quality of language in the manuscript:  
Needs some language corrections before being published  
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the  future?  
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the conten t of the manuscript?  
5. Do you have any other financial competing interests?  
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
I declare that I have no competing interests  
I agree to the open peer review policy of the journal. I understand that my name will be included 
on my report to  the authors and, if the manuscript is accepted for publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Co mmons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidential comments 
to the editors, which will not be published.  
I agree to the open  peer review policy of the journal