Review for 10.1186/s12876-019-1080-3 (2019)

Reviewer ’s report  
 
Title: SNHG 6 Promotes the Progression of Colon and Recta l Adenocarcinoma via miR -101-3p 
and Wnt/ β-catenin Signaling Pathway  
 
Version: 0 Date: 26 Aug 2019  
 
Reviewer: Yuusaku Sugihara  
 
Reviewer's report:  
 
Comments to the Author  
 
In this manuscript, the authors conducted small nucleolar RNA host gene 6 (SNHG6) regulates 
diverse bio logical processes in cancers. Potential function of SNHG6 in human colon and rectal 
adenocarcinoma (CRC) was evaluated.  
 
The conclusion was that SNHG6 could regulate the progression of CRC via via modulating the 
expression levels of miR -101-3p and the acti vity of Wnt/β -catenin signaling.  
 
This study represents an effort to accomplish this, as these data will most likely prove to be a 
unique resource well into the future.  
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments  to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical revi ew? 
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
Quality of written English  
Please indicate the qual ity of language in the manuscript:  
 
Acceptable  
 
 
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in t he past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisat ion t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursemen ts, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to t his paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
none  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors' 
responses. I ag ree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidential c omments 
to the editor s, which will not be published.  
 
I agree to the open peer review policy of the journal