Review for 10.1186/s12876-020-01451-4 (2020)

Reviewer ’s report  
 
Title: Infantile fever -triggered acute liver failure caused by novel neuroblastoma amplified  
sequence mutations: a case report  
 
Version: 1 Date: 21 Jul 2020  
 
Reviewer: Research Square Reviewer 1  
 
Reviewer's report:  
 
PEER REVIEWER ASSESSMENTS:  
 
OBJECTIVE - Full res earch articles: is there a clear objective that addresses one or several testable 
research questions? (Brief or other article types: is there a clear objective?)  
Yes - there is a clear objective  
 
DESIGN - Is the current approach (including controls and ana lysis protocols) appropriate for the 
objective?  
Yes - the approach is appropriate  
 
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to 
allow confidence in the results?  
Yes - experiments and analyses were performed appr opriately  
 
STATISTICS - Is the use of statistics in the manuscript appropriate?  
N/A - there are no statistics in this study  
 
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not 
overstated?  
N/A - no results to interpret  
 
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently 
for you to now recommend the work as a technically sound contribution? If not, can further 
revisions be made to make the work technically soun d? 
Yes - current version is technically sound  
 
PEER REVIEWER COMMENTS:  
 
GENERAL COMMENTS: The manuscript provides interesting information regarding this topic. 
The authors have addressed all the reviewers´comments and suggestions.  
 
REQUESTED REVISIONS:  
English editing is correct although the sentence in lines 9 -10 of the abstract is still confusing.  
ADDITIONAL REQUESTS/SUGGESTIONS:  
no further comments  
 
Publons Reviewer Recognition . Springer Nature can send verifica tion of this review directly to 
Publons ( a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, 
please click on the “Yes” option below. Your name, email  address, title of the reviewed manuscript, 
name of the journal, and date of your review submission (the “Review Data ”) will then be 
transmitted to Publons upon publication of the manuscript.  If you have already registered at 
Publons, they will notify you of the receipt of this review and update your profile as per your 
settings and their policy. If you are not r egistered with Publons,  you will receive an email from 
them asking you to register in order for them to be able to re cognize your review on your new 
profile page. Publons may use the Review Data to generate derivat ive metadata for t he benefit 
ofPublons an d you as a reviewer, carefully considering the sensi tivity of such information. For 
example, Publons may verify your record as a reviewer by updatin g your profile published on its 
webservice if you have registered for such service or help editors t o identify candidate reviewers. 
Please find the details of processing in Publons ’ privacy policy https://publons.com/about/terms  
 
No 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an additional 
statisti cal review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in th e manuscript:  
 
Needs some language corrections before being published  
 
 
 
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past  five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation tha t may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fee s, funding, or salary from an organization that holds 
or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this pap er? 
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.  
If your reply is yes to any, please give details below.  
 
This reviewer has been recruited by a partner organizatio n, Research Square. Reviewers with 
declared or apparent competing interests are not utilized for t hese reviews. This reviewer has 
agreed to publication of their comments online under a Creat ive Commons Attribution License 
attributed to Research Square and was paid a small honorarium for  completing the review within 
a specified timeframe. Honoraria for reviews such as this are paid regardless of the reviewer  
recommendation.  
 
Reviewer Publication Consent. I agree for my report to be made  available under an Open Access 
Creative Commons CC -BY License ( http://creativecommons.org/licenses/by/4.0 ) if this 
manuscript is accepted for publicati on. Any comments that I do not wish to be included in the 
published report have been included as confidential comments to the editor, which will not be 
published.  If you are not happy for us to publish this report, please contact the editorial office 
before  completing the review.  If you wish, you can include your name in your publish ed report. 
Please note you must decide whether to include your name at the start of the process and  confirm 
this decision whenev er prompted. If you change your decision later, we will not be able to publish 
your name.  
 
I agree to the terms of the CC -BY 4.0 license; please publish my name with my report.