Review for 10.1186/s12876-022-02151-x (2022)

Reviewer’s report
Title: 
Characteristics and potential malignancy of colorectal juvenile polyps in
adults: A single-center retrospective study in China
Version: 
1 
Date: 
26 Jan 2022
Reviewer's report:
PEER REVIEWER ASSESSMENTS: 
OBJECTIVE - Full research articles: is there a clear objective that addresses one
or several testable research questions? (Brief or other article types: is there a
clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols)
appropriate for the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient
technical rigor to allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results
reasonable and not overstated?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your
concerns sufficiently for you to now recommend the work as a technically sound
contribution? If not, can further revisions be made to make the work technically
sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS: 
GENERAL COMMENTS: The authors have improved the manuscript based on
the comments. However, I still have some suggestions to improve the manuscript
further. 
1.The English grammar and fluency can still be improved. 
2.In Abstract, revise "CSM was observed beside" to "CSM was observed
adjacent to"
3. 
The findings of the study need to be better clarified. 
The authors identify that
there is 1% malignancy and 6.5% low-grade intra-epithelial neoplasia associated
with these polyps. 
If they could differentiate the subgroup of patients who
displayed these characteristics versus the remaining patients with benign polyps,
they could create some guidelines to predict the patients who would be at risk to
have a non-benign polyp.
4. Discussion can be shortened a little bit.
5. The authors do a good job in describing their findings, but a take home
message is missing. 
How will the findings of this study change the management
of these polyps and patients?
REQUESTED REVISIONS: 
Please see my comments above
ADDITIONAL REQUESTS/SUGGESTIONS: 
Please concentrate on what their findings mean in terms of changing the
management of patients or changing our understanding of these polyps. They
touch on the pathogenesis and create a hypothesis, but insight into clinical
management is missing.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
No
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
No
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes