Review for 10.1186/s12876-021-02064-1 (2021)

Reviewer’s report
Title: 
Ultrasound contrast agent Sonazoid for the diagnosis of hepatic epithelioid
angiomyolipoma :a  case report
Version: 
0 
Date: 
18 Jun 2021
Reviewer's report:
This is a nice case that illustrates the potential of contrast-enhanced ultrasound
for the characterization of hepatic epithelioid angiomyolipoma (HEAML)
I have the following minor comments
Intro 
Please give the risk of malignant transformation of HEAML
I suggest to change "new concepts for identification of HEAML and HCC" for
"new concepts to discrimination between HEAML and HCC"
Main Manuscript
The authors use alternatively passive and active voice. Please use one
consistently
The authors should add that the diagnosis of epithelioid type of HAML was
definitely confirmed by presence of both HMB-45 and SMA
Figures
The authors should pay more attention to the figures that must be improved as
they are a major point of the paper.
Delete 1 and 2 from images and keep only letters (a, b, c, d). Provide more
cropped images and add arrows to show the specific points
CT images must be improved. Delete text from images, provide more cropped
images and add arrows/arrowheads
Figure legends need some minor polishing
Please use the present tense for figure legends.
The 
mass displays "hyperenhancement" instead of "hyperenhancing"
I suggest using "during" instead than "in" for during portal venous phase (during
refers to time wheareas in refers to localization)
References
Please add this recent reference that shows a nice HEML and stresses the need
for presence of both HMB-45 and SMA for a definite diagnosis of epithelioid
type of HAML
Nguyen TTL, Terris B, Barat M. 
Hepatic epithelioid angiomyolipoma mimicking
hepatocellular carcinoma. Diagn Interv Imaging 2020;101(7-8):501-503.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes