Review for 10.1186/s12876-020-01585-5 (2021)

Reviewer’s report
Title: 
Application of Artificial Intelligence in Chronic Liver Diseases: A
Systematic Review and Meta-analysis
Version: 
0 
Date: 
26 Oct 2020
Reviewer's report:
In this article the author perform well-designed meta-analysis with clinically
relevant subgroup analyses to pool the existing evidence of diagnostic accuracy
of AI-assisted diagnosis of chronic liver diseases. The article is well-written, I
only had a few comments:
1. The authors should cite a recent review article in Hepatology ("Applying
Machine Learning in Liver Disease and Transplantation: A Comprehensive
Review") and discuss some of their results and the discrepancies between this
submitted study and the review to emphasize the uniqueness and noteworthy of
this submitted study.
2. For studies that utilized AI-assisted imaging diagnosis of
fibrosis/cirrhosis/steatosis, the authors should also meta-analyze the diagnostic
performance of radiologists and present in supplemental data. In this manner we
would be able to further pinpoint the advantages of leveraging AI. 
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
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Yes
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Yes
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from apparent manipulation?
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