Review for 10.1186/s12876-017-0569-x (2017)

Reviewer’ s report
Title: First clinical experience in 14 patients treated with ADVOS: A study on feasibility, safety
and efficacy of a new type of albumin dialysis
Version: 0Date: 09 Jul 2016
Reviewer: Andrzej Wincewicz
Reviewer's report:
The authors present a method of ADVanced Organ Support (ADVOS) in the paper numbered
BMGE-D-16-00192. The study group included only 14 patients as this is preliminary study - as Ibelieve -but authors are cautious enough in their evaluations being aware of limitations. Theauthors emphasized on its feasibility, safety and effectiveness of a new type of albumin dialysis.The method was introduced in not earlier than 2005, however its propagation is not satisfying sofar. The paper is of great clinical importance due to deficit of liver donors and it shows a feasibleway of treatment of patients who wait in line for transplantation or are excluded fromtransplantation for number of reasons. The authors compare with ADVOS other analogousmethods SPAD and MARS in discussion for the merit of readership.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
YesDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
NoAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statisticsQuality of written English
Please indicate the quality of language in the manuscript:
Acceptable
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