Review for 10.1186/s12876-020-01359-z (2020)

Reviewer’ s report
Title: A case report of gastric amyloidosis due to multiple myeloma mimicking gastric cancer
Version: 0Date: 05 May 2020
Reviewer's report:In this manuscript, a rare case of gastric amyloidosis has been described in presence of prevalent
gastrointestinal symptoms.Red Congo staining of gastric biopsies finally allowed a delayed and
difficult differential diagnosis with Gastric Cancer.The AA suggest a current use of red Congostaining for differential diagnosis between amyloidosis and Gastric Cancer. The case report is ofclinical interest in dependence on infrequent gastric involvement of amyloidosis. Neverthelessalmost criticisms can be carried out.Signs of a systemic disease as skeletal Rx-lesions, anemia,renal failure, higher circulating immunoglobulin levels (monoclonal?) and presence of λ
circulating chain were early present in association to gastrointestinal symptoms. Surprisingly thesefindings have been underestimated by focusing attention of gastrointestinal symptoms anddelaying a correct diagnosis. On basis of this case report we believe that the usefulness of redCongo staining of gastric biopsies must be considered and evaluated with a clinical andbiochemical investigation context.In addition the discussion appears of difficult lecture a could beshorted.
Are the methods appropriate and well described?
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Yes
Does the work include the necessary controls?
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YesAre the conclusions drawn adequately supported by the data shown?
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NoAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
Not relevant to this manuscriptQuality of written English
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Acceptable
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