Review for 10.1186/s12876-022-02320-y (2022)

Reviewer’s report
Title: 
Protocol of a randomized, double-blind, placebo-controlled study of the
effect of probiotics on the gut microbiome of patients with gastro-oesophageal
reflux disease treated with rabeprazole
Version: 
0 
Date: 
24 Jan 2022
Reviewer: 
Luis Vitetta
Reviewer's report:
1. This is a protocol presentation manuscript for review. 
2. In the consort diagram (Fig 1) add at the end the number of evaluable
participants in both groups that will have data analysed.
3. Safety information is provided as is a self accountability section for the the
administration of the products, it would beneficial to add some information on
tolerability to the test drug in combination with the pharmaceutical medicine and
how this will be assessed. 
4. the study is double blinded, consider blinding also a participant carer and the
independent statistician if not already done so.
5. provide the dose of the probiotics to be administered and also individual
concentrations of the probiotic species to be administered.
6. in the statistical section...will the data be analysed as an intention to treat
analysis? Clarify
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