Review for 10.1186/s12876-024-03431-4 (2024)

Title: Diagnosing celiac disease in children using oral manifestations
Version: 3 Date: 24 Aug 2024
Reviewer's report:
Dear Editor,
I should first thank for inviting me as potential reviewer to read and comment on paper entitled
‘Diagnosing celiac disease in children using oral manifestations’’.
In the current study, the authors aimed to diagnose CD by utilizing documented
oral manifestations such as Recurrent Aphthous Stomatitis (RAS) and Molar-Incisor
Hypomineralization (MIH).
The main title accurately reflects the major topic and content of the study.
The abstract summarizes and reflects the work described in the manuscript. Also, the abstract
presents the significant points related to the background, objectives, materials and methods,
results and conclusions.
The materials and methods sufficiently described for the results and conclusions that are
presented in the preceding sections. The study type and design were defined in the section of
the materials and methods. Inclusion and exclusion criteria are well defined. Figures and tables
are sufficient and well-organized. Ethics Committee approval was received. So, the section
materials and methods is adequate.
The statistical methods used are appropriate.
The section of the discussion is well organized. The conclusions are drawn appropriately
supported by the literature. The manuscript adequately describes the background, present
status and significance of the study. The manuscript interprets the findings adequately and
appropriately, highlighting the key points clearly.
I think that it will contribute to the literature. I have some minor criticisms.
- According to ESPGHAN updated guidelines, HLA genotyping is no more necessary. I noticed
that HLA analysis was performed in the study. I think because it was a retrospective study,
analyzes were done at that time. Please state it in the manuscript.
- The following reference is not enough at the background part of the manuscript, please
change it and add recent published references such as ‘’ Celiac disease in children: A review
of the literature. World J Clin Pediatr. 2021 Jul 9;10(4):53-71’’; ‘’ Frequency of celiac disease
and distribution of HLA-DQ2/DQ8 haplotypes among siblings of children with celiac disease.
World J Clin Pediatr 2022;11: 351-359‘’; ‘’Eur J Rheumatol. 2019 Apr 22;6(3):142-145.
Serological screening for celiac disease in children with systemic lupus erythematosus; ‘’Arab
J Gastroenterol. 2019 Jun;20(2):95-98. Serological screening for coeliac disease in patients
with juvenile idiopathic arthritis’’; ‘’The frequency of celiac disease in children with chronic
constipation. Kuwait Med J 2021; 53: 383-387’’If the recent published articles about celiac
disease, are cited, the manuscript would be better.
‘’Celiac disease is characterized by gastrointestinal and/or systemic problems such as diarrhea,
abdominal discomfort, vomiting, anorexia, fatigue, depression/anxiety, joint/muscle pain,
dermatitis, anemia, rhinitis/asthma/allergy, sleep disruption, irregular bowel movements,
constipation, and bloating. However, CD can still go undiagnosed because many CD patients
have no classic gastroenterologic symptoms and may be completely asymptomatic [1]’’
After careful revision, I think that it will contribute to the literaturature.