Review for 10.1186/s12876-020-01298-9 (2020)

Reviewer ’s report  
 
Title: Hypophosphataemia after ferric carboxymaltose is un related to symptoms, intestinal 
inflammation or vitamin D status  
 
Version: 0 Date: 13 Feb 2020  
 
Reviewer: Guy Rostoker  
 
Reviewer's report:  
 
Please include all comments for the authors in this b ox rather than uploading your report as an 
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This study meticulously analyzed prospectively the kinetic of FCM -induced hypophosphatemia 
during 28 days in a group of IBD patients as compared to controls without gut disease (I guess)  
having severe iron deficie ncy requiring IV iron.  
 
Authors have extensively analyzed the role of inflammation, type of gut disease , Vitamine D 
status in the occurence and severity of hypophosphatemia. They also confirm the role of the 
increase of intact FGF -23 in the pathophysiology  of this event. Interestingly, patients with either 
ulcerative colitis or Crohn disease do not seem more prone to FCM -induced hypophosphatemia 
than iron deficiency patients (without gut disease).  
 
One point that authors should improve deals with a detailed  description of the so -called control 
group (with severe iron deficiency).  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls  are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
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