Review for 10.1186/s12876-021-01715-7 (2021)

Reviewer’s report
Title: 
Very-Low-Dose Aspirin and Surveillance Colonoscopy is Cost-effective
in Secondary Prevention of Colorectal Cancer in Individuals with Advanced
Adenomas: Network Meta-analysis and Cost-effectiveness Analysis
Version: 
0 
Date: 
26 Jan 2021
Reviewer's report:
The authors describe the benefit of a prolonged low dose aspirin treatment in
secondary 
colorectal cancer in individuals with advanced adenomas.
The study is interesting and it gives some suggestions in order to reduce the
incidence of colon cancer and 
the cost of colorectal cancer prevention .
I think that could of interest a more extensive description of these points :
- The authors should describe the rate of adverse effects among patients treated
with low dose of ASA , the rate of ASA discontinuation and the use of other
drugs in order 
to prevent ASA adverse events and how these events influence the
cost of colorectal prevention .
- Advanced colorectal adenomas include villous adenomas and adenomas with
neoplastic intra-mucosal invasion . 
Is there any difference in the efficacy of ASA treatment in the prevention of
colorectal cancer among the different types of advanced adenomas?
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
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Yes
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from apparent manipulation?
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