Review for 10.1186/s12876-022-02163-7 (2022)

Reviewer’s report
Title: 
Risk stratification for predicting postoperative recurrence/metastasis of
colorectal cancer by grade of venous invasion coupled with histological subtype
Version: 
0 
Date: 
04 Nov 2021
Reviewer: 
Jamshid Abdul-Ghafar
Reviewer's report:
A good study by Yasuo Imai and Masanori Ichinose about the effects of
histopathological subtypes and venous invasion on colorectal carcinoma. Even
though the effect of venous invasion on the prognosis and metastasis of cancers
of different organs are clear with many published papers about it, but the focus
of this study on different histopathologic types of CRC along with venous
invasion is very interesting topic. I have some minor points to be revise:
1. The Title of study is not clear. It should describe your finding (like high grade
venous invasion and/or poorly differentiated histopathologic type have what kind
of effect on the prognosis and/or metastasis of CRC). I recommend to revise the
title.
2. In the Background section, there is no citation on line 7 to 12. Also, I think
this is a very basic information and you do not need to explain it here. 
3. Information regarding the subtypes of CRC, venous and lymphatic invasions
are less in the background section. I recommend to add some more information
about these points.
4. Can you explain the reason why you have selected cases from different years
from 3 hospitals? 
5. Why did you used old versions of WHO and AJCC books, while the new
versions are already in the market?
6. I recommend English spelling and grammar revision as well. You have use
abbreviation with full word in the first time, P for p-value should be small letter
and italic and many more small corrections needed.
7. Figures quality is very low and difficult to see. I recommend to change them
with higher quality figures.
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