Review for 10.1186/s12876-020-01298-9 (2020)

Reviewer ’s report  
 
Title: Hypophosphataemia after ferric carboxymaltose is un related to symptoms, intestinal 
inflammation or vitamin D status  
 
Version: 1 Date: 13 Mar 2020  
 
Reviewer: Trond Espen Detlie  
 
Reviewer's report:  
 
Congratulations on a nice paper.  
 
I still feel that my comment related to line 239 -246 in the previous version, now line 197 -204 in 
the current ver sion, is relevant. However, if the authors choose to keep this section I would 
recommend to specify how many of the 5 patients had received FCM within the last 6 months 
and make a comment on if any of the patients had a state of hypophosphatemia at inclusi on of 
this study. The theory of an additive effect of repetitive infusions of FCM is that the patients 
have not had the time to normalize their blood values before the next infusion. This includes 
phosphate, iFGF23, PTH, ionized calcium, Vitamin d etc. Sin ce there is no good data (except for 
some case reports) on a prolonged effect beyond 6 months I feel this needs to be addressed when 
using a timeline of 12 months in this section. The way it is now phrased might give a misleading 
impression that there is n o increased risk for patients receiving repetetive infusions of FCM. This 
is somewhat the opposite of what is believed to be true and ,hence, the text should therefor be 
more specific in this regard.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls  are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
 
 
 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
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