Review for 10.1186/s12876-021-02053-4 (2021)

Reviewer’s report
Title: 
Significant response to atezolizumab plus bevacizumab treatment in
unresectable hepatocellular carcinoma with major portal vein tumor thrombus: a
case report
Version: 
0 
Date: 
30 Oct 2021
Reviewer's report:
Thank you for this interesting case. The case is interesting and opens a new hope
for HCC advanced patients; However; some changes are needed:
- Introduction: You should shed light on the recent role of immunotherapy on the
management of HCC; some light on immune check points and dendritic cells as
emerging therapy for HCC.
-Discussion: You should clearly demonstrate the impact of this on our current
clinical practice as well as the future implications. You should also compare with
other recent trials discussing immunotherapy in management of HCC.
-In discussion in this case; you should shed light on PVT; and if you think
immunotherapy is sufficient in this case or anticoagulants may also be needed.
-References need updating with only 2 references from the last 3 years; I suggest
adding these important and relevant references:
=Autologous dendritic cells pulsed with lysate from an allogeneic hepatic cancer
cell line as a treatment for patients with advanced hepatocellular carcinoma: A
pilot study. Int Immunopharmacol. 2020 Mar 10;82:106375.
=MicroRNA signature in hepatocellular carcinoma patients: identification of
potential markers. Mol Biol Rep. 2020 Jul;47(7):4945-4953.
=Role of low-molecular-weight heparins in prevention of thromboembolic
complication after transarterial chemoembolization in hepatocellular carcinoma.
Eur J Gastroenterol Hepatol. 2017 Mar;29(3):317-321.
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