Review for 10.1186/s12876-022-02496-3 (2022)

Reviewer’s report
Title: 
Mutational and transcriptional alterations and clinicopathological factors
predict the prognosis of stage I hepatocellular carcinoma ---Prediction of stage I
HCC prognosis
Version: 
0 
Date: 
22 Jun 2022
Reviewer's report:
1. A very well written research article, but might need some correction of
grammatical errors.
2. A mention of therapy in association with these molecular alterations in
important. The prognosis might also depend on what therapy given and at what
stage surgery was performed.
3. While these alterations do occur in stage 1; there is no significant difference in
the alterations seen in advanced stages. 
4. HCC is seen in patients with cirrhosis or other underlying liver disease, how
does prognosis and molecular alterations in such cases differ from cases with no
underlying liver disease. 
5. Hepatitis is another important factor contributing to the burden of HCC and
their role in oncogenesis and molecular pathways need elaboration and are
relevant to this research article, and how the described alterations affect the
prognosis and monitoring of pts with chronic HBV and HCV infections.
6. Chromosomal abberations associated with these alterations can be mentioned
and will provide and indepth review if mentionned.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
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