Review for 10.1186/s12876-018-0851-6 (2018)

Reviewer ’s report  
 
Title: Amoxicillin/Clavulanic Acid -Induced Pancreatitis: Case Report  
 
Version: 0 Date: 22 Jan 2018  
 
Reviewer: Bhavana Bhagya Rao  
 
Revi ewer's report:  
 
The report describes a single case of possible augmentin related pan creatitis. While this is rarely 
encountered, the case does not definitively indicate a drug related etiology and does not meet 
novelty criteria to justify publication in this journal.  
Had the patient previously been exposed to other types of penicillin ag ents? Any adverse events 
during such exposures? This is important to tease out before seeming this to be a drug related 
event.  
When the authors report that patient admitted to moderate drinking this would need to be 
quantified.  
While two sections say that the patient denied any alcohol intake ever in the case description 
moderate drinking is reported. This needs to be clarified as it has a profound implication in the 
etiology of this patient's pancreatitis.  
Was Genetic testing undertaken in this patient to rule out hereditary pancreatitis? What about 
IGG4 level estimation for evaluation of autoimmune pancreatitis? Without these tests it is 
challenging to definitively attribute his pancreatitis to drug exposure.  
The manuscript is very long and repetitive and would need to be shortened.  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include th e necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
No 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
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manuscript?  
 
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holds  or has applied for patents relating to the content of the manuscript?  
 
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below.  If your reply is yes to any, please give details below.  
 
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