Review for 10.1186/s12876-021-01755-z (2021)

Reviewer’s report
Title: 
Optimal Timing of Endoscopic Retrograde Cholangiopancreatography for Acute Cholangitis
Associated with Distal Malignant Biliary Obstruction
Version: 
0 
Date: 
24 Feb 2021
Reviewer's report:
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Dear Authors,
I read with interest this paper about timing of ERCP in patients affected by colangiti complicating a distal
biliary obstruction. Though retrospective, the design is adequate and gives an important message for
clinical practice. I would suggest to add a comment in the discussion about the selection criteria for urgent
ERCP. Do you follow a clinical criteria? Do you apply any sort of internal guideline? Or is it the choice
completely demanded to the gastroenterologist on call? Another interesting question is the "week-end
effect", because during week-ends a significant number of ERCP is delayed. It would be worth
commenting about this. Thank you for your work and congratulations.
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Is the study design appropriate to answer the research question (including the use of appropriate controls),
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