Review for 10.1186/s12876-020-01413-w (2020)

Reviewer’ s report
Title: Rotational thrombelastometry (ROTEM) improves hemostasis assessment compared to
conventional coagulation test in ACLF and Non-ACLF patients
Version: 0Date: 03 May 2020
Reviewer's report:
In this paper, the authors aim to examine hemostasis in patients with stable liver cirrhosis (Non-
ACLF) and in acute-on-chronic liver failure (ACLF) by conventional coagulation tests (CCTs) andRotational thromboelastometry (ROTEM) and to further verify the strength of agreement betweenthese two methods.. The authors demonstrated that ROTEM showed superiority to CCT forassessing hemostasis in Non-ACLF and ACLF patients. Overall, the data provided here by theauthors could have interesting implications. Several points need to be considered are listed below:
1. The authors need to include brief introduction of the 5 tests (INTEM, EXTEM, FIBTEM,
APTEM and NATEM) in the Introduction section.2. It would be better to move the Supplemental table 1 as Table 7, because, as the authorsmentioned in the Discussion, the data presented about bleeding events is very interesting.3. In the Discussion section, the authors can discuss the potential applications of ROTEM inpatients with liver cancer.4. The authors need to check the text carefully to correct typos, such as removing the extra '.' andadding 'space' between words.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
YesDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
AcceptableDeclaration of competing interests
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