Review for 10.1186/s12876-017-0569-x (2017)

Reviewer ’s report  
 
Title:  First clinica l experience in 14 patients treated with ADVOS: A study on feasibility, safety 
and efficacy of a new type of albumin dialysis  
 
Version: 0 Date: 21 Jul 2016 
 
Reviewer:  Biju Pottakkat  
 
Reviewer’s report:  
 
Page 9, Line 22 -23 
 
The diagram provided shows a counter current circuit where blood and dialysate flows in 
opposite directions  where as authors state that flow is parallel . Correct in the manu script .  
 
Page 9, Line 32  
 
How many patients recieved hemofiltration in the post dilution mode ? Does the system permits 
choosing between pre and post dilution modes ?  
 
Page 9, Line 33  
 
Specify whether a conventional dialysis/CRRT machine was used for setting up the primary and 
secondary circuit ?If so give model and manufacturer details .  
 
Page 9, last line  
 
In which part of the circuit temperature modulation was undertaken?  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the  necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.   
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the  editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
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