Review for 10.1186/s12876-022-02267-0 (2022)

Reviewer’s report
Title: 
Signet-ring cell carcinoma of the duodenal bulb
presenting with gastrointestinal hemorrhage: a case report and literature review
Version: 
0 
Date: 
04 Jan 2022
Reviewer's report:
Several major points in the manuscript should be clarified:
1. Manuscript requires language correction and formatting.
2. Reference should follow standard journal format. Eg: Reference no: 1 and 4,
in line number 65 and 69.
3. Please cross check line no: 137 and 138 on ethics approval statement. Give
details.
4. What were the post operative treatment strategies given to the patient,
considering patient still suffered from repeated gastrointestinal bleeding?
5. Please specify the tumor grade.
6. As mentioned in the manuscript line no: 78-80, endoscopy can be the main
diagnostic method at present for duodenal cancer, with a diagnostic rate of
92.31%. Whether endoscopic examination was done in this case?
7. Apart from endoscopy and biopsy recommendation in the manuscript, whether
more cancer biomarkers testing would have helped for early diagnosis? Are there
any specific reported biomarkers for duodenal SRCC?
8. As there was reported family history of lung cancer, whether genetic
counselling was considered?
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
No
Are the methods sufficiently described to allow the study to be repeated?
No
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No
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No
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
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