Review for 10.1186/s12876-023-02692-9 (2023)

Reviewer’s report
Title: 
Lifestyle Factors associated with Inflammatory Bowel Disease: Data from
the Swiss IBD Cohort Study
Version: 
1 
Date: 
23 Dec 2022
Reviewer's report:
Were familial cases (especially brothers and sisters) included in the target?
For the period of childhood to the begin of adulthood, the report for 257 (42.1%)
patients with CD and 181 (38.7%) patients with UC/IC presented no regular
activity, whereas only 107 (29.3%) persons from the control group did not
practice sport regularly (p=0.001) (Table 2).This reviewer has a concern about
the relationship between the period to survey physical activity and the onset of
IBD. Wouldn't it be possible that the subject had already developed symptoms
and that regular activity had decreased as a result?
The authors' results suggest that childhood obesity may contribute to the
development of IBD. On the other hand, Jain et al reported no association
between obesity and disease activity in new-onset childhood and adolescent IBD
patients (Am J Gastroenterol 2022; 117:1146-1153). The authors 
are allowed to
discuss about this difference.
The results that childhood obesity and breast milk corelated with the
development of IBD may suggest that dysbiosis of the gut microbiome is
involved in it. Please have a little more discussion on this point.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
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Yes
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Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes
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No