Review for 10.1186/s12876-020-01410-z (2020)

Reviewer’ s report
Title: Efficacy of a High-Dose Proton Pump Inhibitor in Patients with Gastroesophageal Reflux
Disease: A Single Center, Randomized, Open-Label Trial
Version: 0Date: 01 May 2020
Reviewer's report:
In this study entitled "Efficacy of a High-Dose Proton Pump Inhibitor in Patients with
Extraesophageal Symptoms of Gastroesophageal Reflux Disease: A Single Center, Randomized,Open-Label Trial", the authors compared the efficacy of proton pump inhibitor (PPI) in patientswith extraesophageal symptoms of Gastroesophageal Reflux Disease (GERD). This prospectivestudy is interesting, however several limitations are described as follows.
1. In the Abstract, was high-dose PPI more effective than standard-dose regimen for typical GERD
symptom, not for atypical symptom? Conclusion is inaccurate.2. In the Study protocol, how did you use the randomization method?3. In the Study protocol, did you check the H.pylori infection by using urease test? Table 1 showsconfusing results.4. In the Study protocol, how did you calculate sample size?5. In the Statistical analysis, did you perform per-protocol analysis only?6. Figure 2 shows the data same as Table 3.7. Figure 1 shows the high drop-out ratio of the enrolled patient. This is a crucial bias andlimitation. Please disscuss it.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
NoDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
AcceptableDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
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3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
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If your reply is yes to any, please give details below.
I declare that I have no competing interests' below.Reviewer Publication Consent. I agree for my report to be made available under an Open Access
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