Review for 10.1186/s12876-020-01486-7 (2020)

Reviewer’s report
Title: 
Development of significant disease in a cohort of patients with non-
specific enteritis on capsule endoscopy. Clinical suspicion and a high base line
Lewis score are predictive of Crohn’s disease.
Version: 
1 
Date: 
24 Aug 2020
Reviewer's report:
PEER REVIEWER ASSESSMENTS: 
OBJECTIVE - Full research articles: is there a clear objective that addresses one
or several testable research questions? (Brief or other article types: is there a
clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols)
appropriate for the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient
technical rigor to allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results
reasonable and not overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your
concerns sufficiently for you to now recommend the work as a technically sound
contribution? If not, can further revisions be made to make the work technically
sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS: 
GENERAL COMMENTS: please note this is a re-review and I will outline in
the evaluation the headings of a re-review which 
HAVE THE AUTHORS RESPONDED ADEQUATELY TO EACH OF THE
QUESTIONS YOU RAISED IN YOUR COMMENTS 
Let me start by saying that I was not one of the original reviewers. So I will
review this as a primary review as well as looking at the prior excellent
comments and the author's responses 
I have read the responses carefully and yes I believe that the authors have
addressed all the comments upfront
HAVE THEY MADE THE APPROPRIATE CHANGES IN THE
MANUSCRIPT 
Yes I support their appropriate responses
WHAT IS YOUR OVERALL IMPRESSION OF THE REVISED
MANUSCRIPT 
This revised version addresses the reviewers suggestions and I believe offers
useful information concerning the go so f of "enteritis" on capsule endoscopy-
possible the most Interesting outcomes were the prevalence of NSAIDS 
-related
lesions as well as Crohn's disease
will answer the above questions as well
IN WHAT WAYS DOES IT NOT MEET BEST PRACTICE
This study does meet best practice 
Ideally they would have tried to get follow up
on the 169 patients from outside their practice
REQUESTED REVISIONS: 
ARE THERE ANY ADDITIONAL REVISIONS THE AUTHORS SHOULD
MAKE
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Declaration of competing interests
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes