Review for 10.1186/s12876-020-01406-9 (2020)

Reviewer ’s report  
 
Title: Association of Helicobacter pylori vacA genotypes and peptic  ulcer in Iranian population: 
a systematic review and meta -analysis  
 
Version: 0 Date: 12 Jun 2020  
 
Reviewer's report:  
 
1. Even authors had point their study was just related t o Iranian population, the readers of 
BMC gastroenterology were included global gastroenterologists. In discussion section; authors 
had demonstrated some other related studies and I suggest authors may consider make a table to 
compare the difference of vac A genotype between Iranian population and other area (such as 
Europe or east Asia).  
 
2. According to BMC gastroenterology Submission Guidelines 
"https://bmcgastroenterol.biomedcentral.com/submission -guidelines/preparing -your-
manuscript/research -article" Th e reference style had clearly demonstrated. The authors didn't 
follow up these requests. Especially in reference 33, 35, 42; authors need re -writing their 
reference and follow up BMC gastroenterology Submission Guidelines.  
 
3. Helicobacter pylori infectiou s status sometimes was related to socioeconomic class. In 
authors collected material and studies, does any relationship between socioeconomic class and 
vac A genotype? Or vac A genotypes would associated to regional effect? Please add these 
issues in the d iscussion section.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you ab le to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
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from an organisation that may in any way gain or lose financial ly from the 
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future?  
 
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of the manuscript?  
 
4.  Have you received reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
 
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I declare that I h ave no competing interests  
 
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