Review for 10.1186/s12876-021-01890-7 (2021)

Reviewer’s report
Title: 
Health-Related Quality of Life in Outpatients with Chronic Liver Disease:
a cross-sectional study
Version: 
1 
Date: 
05 Jul 2021
Reviewer's report:
The topic of the paper is original, conducted with an appropriate methodology. 
The results highlight a lack of association between the severity of liver disease
and cognitive-affective symptoms probably due to a bias of selection due to the
recruitment of patients for the most part belonged to low grades of MELD Score.
Could it be added in the analysis of patients with more severe pathology? If this
is not possible, we recommend specifying and modifying the analysis only on
patients with mild liver disease. In this regard we recommend reading a paper
published on chronic inflammatory bowel diseases of which we attach the
references ( Mancina RM Gastrointestinal Symptoms of and Psychosocial
Changes in Inflammatory Bowel Disease: A Nursing-Led Cross-Sectional Study
of Patients in Clinical Remission. Medicina (Kaunas). 2020 Jan 20;56(1):45. doi:
10.3390/medicina56010045. PMID: 31968710; PMCID: PMC7022245)
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
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