Review for 10.1186/s12876-020-01525-3 (2020)

Reviewer’s report
Title: 
Folate levels in Hepatocellular Carcinoma patients with Portal Vein
Thrombosis
Version: 
2 
Date: 
09 Aug 2020
Reviewer's report:
In the manuscript entitled "Folate levels in Hepatocellular Carcinoma patients
with Portal Vein Thrombosis", authors provide a summary of relationship
between folate level and hepatocellular carcinoma patients with portal vein
thrombosis. There is some significance of this paper to provide information
about agents and technologies for hepatocellular carcinoma combined with
portal vein thrombosis. However, there are some significant problems in the
manuscript, which prevents its publication at current stage.
1.The purpose of this manuscript is ambiguous. Author displayed some results,
but he did not evaluate these results and provide his own comments.
2.In the introduction of some reports, author provided too much detailed data,
but the description in this paragraph is rather confusing, and the relationship
between the sentences is not explained clearly.
3.At the end of this manuscript, author should summarize the significance and
clinical application (providing folate for these patients, etc), which may provide
ideas for future researchers.
4.I consider the paper is a little too simple, and I suggest authors to revise it, and
provide more details.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
No
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
No