Review for 10.1186/s12876-021-02065-0 (2021)

Reviewer’s report
Title: 
Intestinal Behçet’s disease complicated by myelodysplastic syndrome and
secondary pulmonary alveolar proteinosis: A case report
Version: 
0 
Date: 
28 Sep 2021
Reviewer's report:
PEER REVIEWER ASSESSMENTS: 
RELEVANCE - Does this case report make a contribution to medical
knowledge, have educational value, or highlight the need for a change in clinical
practice or diagnostic/prognostic approaches? 
Yes, this report contributes to medical knowledge
CASE DESCRIPTION - Are the details of the case sufficiently well described to
understand the patient's symptoms and course of treatment? 
No - there are minor issues
DIAGNOSIS/INTERPRETATION - Based on the facts presented, are the
diagnosis, interpretation, and course of treatment medically sound?
Yes, the work described is medically sound
DISCUSSION OF THE CASE - Does the discussion appropriately analyse the
importance of the findings and their relevance to future understanding of disease
processes, diagnosis or treatment? Has an adequate literature review pertinent to
the case been included?
No - there are major issues
OVERALL MANUSCRIPT POTENTIAL - Could an appropriately REVISED
version of this work represent a technically sound contribution?
Maybe - with major revisions
PEER REVIEWER COMMENTS: 
GENERAL COMMENTS: The authors present a case report of Behcet disease
in a 58-year old woman showing a rare complication of alveolar proteinosis after
a myelodysplastic syndrome with intestinal localization.
The article find its main interest in the rarity of the complications, but the
authors do not discuss the known possible etiological associations and the
possible causal relationship among them. The surfactant dysfunction could be
secondary to the myelodysplastic syndrome with trisomy 8, which, on turn,
could find its expression in the intestinal localization. 
Finally, the alveolar proteinosis seems a not-so-rare complication of the
myelodysplastic syndrome and this latter is not-so-rare in Behcet disease.
The final outcome of the patient is not described, though the general conditions
are repeatedly described as poor. In the table the patient is reported a salive. The
authors should give the last assessment of the patient at the end of their
description.
The endoscopic pictures are nice, the english language is fine, though it is not
easy to link the sentences one another 
The synoptic table is fine.
The authors should not refer to the year in which the diagnosis was made, but
always to the age of the patient.
REQUESTED REVISIONS: 
See my comments above
ADDITIONAL REQUESTS/SUGGESTIONS: 
The discussion should be focused to try to find the etiological link among the
several manifestations among them (Behcet disease--trisomy 8 bone marrow
dysplasia-- colonic ulcers and alveolar proteinosis
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