Review for 10.1186/s12876-021-01844-z (2021)

Reviewer’s report
Title: 
Tumor-to-tumor metastasis of diffuse large B cell lymphoma to gastric
adenocarcinoma via CXCL12 (SDF-1)/CXCR4 axis: a case report
Version: 
0 
Date: 
02 May 2021
Reviewer's report:
Please describe the dimensions, location and appearance of the right ventricular
tumors. Also please include echocardiographic images. 
Can you add the post R-CHOP regimen recovered endoscopy images. It would
be better if you can compare the pre and post recovered endoscopic images on a
single figure. 
Can you please add cardiovascular manifestation and in general clinical
manifestation of the patients. It has been just described as chest discomfort
without any intricate essential details for clear communication. 
The author describes a mechanism for the tumour migration which is interesting.
Can you please add a graphic illustration explaining the mechanism. This will
make communication more lucid. 
Please note that if there are restrictions for the number of images, please add it as
a supplementary (OR) club appropriately 
Please also add annotations to the images. "Mind does not see what the eyes do
not know." So unless we annotate each and every description of the text in the
image (both histology, endo and echo), readers especially with low experience
would find it difficult to follow. 
The author claims that their findings were novel. They should also explain the
manner in which their case is different from previously reported cases. There has
been a reported case of ileocaecal DLBCL occurring along with gastric
adenocarcinoma. 
"Diffuse large B-cell lymphoma with concurrent gastric adenocarcinoma: case
report and literature review"
The conclusion in the abstract needs to be rewritten in a better way. The line
"Actually, one trial ….. Staining" is not required. 
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
No
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes