Review for 10.1186/s12876-018-0851-6 (2018)

Reviewer ’s report  
 
Title: Amoxicillin/Clavulanic Acid -Induced Pancreatitis: Case Report  
 
Version: 1 Date: 19 Apr 2018  
 
Reviewer: Rakesh Aggarwal  
 
Reviewer's report:  
 
This manuscript describes a patient with acute pancreatitis in whom no discernible cause was 
found, and there was history of amoxycillin -clavulanate intake a few days ago. Though it is 
possible that the pancreatitis was related to this drug, it is difficult to be reasonably certain of this 
association based on the det ails provided.  
It appears that the original submission was reviewed by another reviewer who raised several 
valid questions. Though the authors have tried to answer those questions, the responses to not 
add to the certainty of the association between the drug and the illness. One needs to bear in 
mind that a large proportion of acute pancreatitis cases are idiopathic, and that may be applicable 
here too.  
The criteria for testing for genetic causes that the authors refer to are for general clinical use, a nd 
do not necessarily apply in this case, where a specific drug -induced cause is being considered.  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Unable to assess  
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
No 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
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3. Do you hold or are you currently applying for any patents relating to the c ontent of the  
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4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
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below.  If your reply is yes to any, please give details below.  
 
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