Review for 10.1186/s12876-018-0826-7 (2018)

Reviewer’s report
Title: A Case Series Evaluating the Impact of Hepatitis C Eradication using Direct Acting Antivirals on
Primary Biliary Cholangitis-Associated Autoimmunity.
Version: 1 Date: 20 Dec 2017
Reviewer: Yoshiiku Kawakami
Reviewer's report:
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This article is described DAA treatment is safe and effective in PBC patients with HCV infection.
Although the number of cases is small, the result that the effect of HCV eradication does not become a
driving source of autoantibodies is an important knowledge in treating DAA in PBC patients with HCV
infection.
Overall the manuscript is very well written. This article is thought to have useful information for
readers of this journal. 
However, I have only minor comments.
Anti-Ro 52, anti-centromere antibodies (Clin Res Hepatol Gastroenterol. 2015 Apr;39(2):222-9. doi:
10.1016/j.clinre.2014.08.004. Epub 2014 Sep 15.) and anti-gp 210 (Aliment Pharmacol Ther. 2017
Mar;45(5):733-743. doi: 10.1111/apt.13927. Epub 2017 Jan 13.) are reported to be associated with
disease progression.
It is desirable to describe if anti-centromere antibodies and anti-gp 210 have been investigated.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
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Yes
Are the conclusions drawn adequately supported by the data shown?
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Yes
Are you able to assess any statistics in the manuscript or would you recommend an additional 
statistical review?
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assessment in your comments to the editors.
Not relevant to this manuscript
Quality of written English
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Acceptable
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