Review for 10.1186/s12876-021-01714-8 (2021)

Reviewer’s report
Title: 
Plasma cell free DNA methylation markers for Hepatocellular Carcinoma
surveillance in patients with cirrhosis: a case control study
Version: 
0 
Date: 
02 Dec 2020
Reviewer's report:
It's a case control study. The authors mentioned that plasma cell free DNA
methylation markers may be useful for the suveillance of Hepatocellular
carcinoma in patients with cirrhosis.
The author showed that the HCCBloodtest and the NGS panel exhibited 76.7%
and 57% sensitivities at 64.1% and 97% specificity,respectively. Therefore, I am
not convinced with their concluding remarks. 
The manuscript is not suitable to publish in this journal.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
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