Review for 10.1186/s12876-017-0575-z (2017)

Reviewer ’s report  
 
Title: A case of multicentric pancreatic mixed acinar -ductal carcinoma diagnosed by a yogurt -
like cell clump flowing from the papilla of Vater  
 
Version: 1 Date: 17 Oct 2016 
 
Reviewer:  Takashi  Muraki  
 
Reviewer’s report:  
 
This is an interesting  case report. There is one critique as mentioned in comments to the author.  
 
As I mentioned and also authors indicated, this case contained acinar -like stricture, ductal -like, 
and NET components. The HE -stain showed relatively typical ACC features, but neg ative for 
trypsin Bcl -10 and lipase. I can understand it was difficult to diagnose as ACC. But at least these 
lesions had differentiations to acinar -like and ductal -like, which means no "poorly differentiated" 
PDAC. If this case is reported as "poorly diff erentiated" PDAC in the literature, it may be 
confused. It may be fine to change/describe more about your final pathological diagnosis and its 
differential diagnosis, such as ITPN, NEC, medullary carcinoma, and so on.  
 
It will be suitable for the aim and t he scope of BMC Gastroenterology, if the authors resolve that 
critique.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Unable to assess  
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please expl ain in your comments to the authors.  
 
No 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require furthe r 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptabl e 
 
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