Review for 10.1186/s12876-021-01812-7 (2021)

Reviewer’s report
Title: 
GRANULOMATOUS COLITIS IN A PATIENT WITH METASTATIC
MELANOMA UNDER IMMUNOTHERAPY A case report and literature
review
Version: 
0 
Date: 
17 Feb 2021
Reviewer's report:
Thank you for inviting me to review this manuscript. The authors reported a case
of immune checkpoint inhibitors-associated granulomatous colitis and review the
characteristics of previously reported cases. Please find my comment below: 
1. Please provide endoscopic pictures. 
2. Please consider provide laboratory investigations such as blood tests. 
3. Did the author perform follow-up colonoscopy with biopsy to confirm the
improvement of colitis? If yes, please add this information including endoscopic
and histologic pictures. 
4. In the Background section, the authors stated that a review of all patients with
ICPIs related to colon granulomas reported in the literature was performed.
Could the author provide a flow diagram of the systematic review the authors
did? 
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes