Review for 10.1186/s12876-021-02079-8 (2022)

Reviewer’s report
Title: 
A Systematic Review of the Patient Burden of Crohn’s Disease-related
Rectovaginal and Anovaginal Fistulas
Version: 
0 
Date: 
06 Aug 2021
Reviewer's report:
PEER REVIEWER ASSESSMENTS: 
OBJECTIVE - Full research articles: is there a clear objective that addresses a
testable research question(s) (brief or other article types: is there a clear
objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols)
appropriate for the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor
to allow confidence in the results?
No - there are minor issues
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results
reasonable and not overstated?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work
technically sound? If not, can revisions be made to make the work technically
sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS: 
GENERAL COMMENTS: 
Overall, this paper looks at an extensive literature review. The search, data
extraction, and data analysis have been conducted rigorously. 
The writing style needs improvement.
REQUESTED REVISIONS: 
Some statements in the article are not correct.
* P10 L24 - "the treatment of fistulas or the underlying CD" diverticulectomy,
hemorrhoidectomy, hysterectomy are not part of Crohns
* P11 L25 - low residue diets
P12 L22 - 13.3% - The quoted studies had sample sizes less than 100, so there
can't be decimal places.
P12 L43 - "The authors report 'modest' scores in the PRO instruments, For
example" - Statement could be improved to convey the idea clearer.
ADDITIONAL REQUESTS/SUGGESTIONS: 
The writing style of the article could be improved. The article, while scientific,
would benefit by conforming to the general writing style of the journal.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
No
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes