Review for 10.1186/s12876-022-02526-0 (2022)

Reviewer’s report
Title: 
Female gender, dissatisfaction with weight, and number of IBD related
surgeries as independent risk factors for eating disorders among patients with
inflammatory bowel diseases
Version: 
1 
Date: 
11 Mar 2022
Reviewer's report:
In the study for the manuscript "Risk factors for eating disorders among patients
with inflammatory bowel diseases" Stoleru et al. applied the EAT-26
questionnaire to identify potential risk factors for eating disorders in patients
with IBD. Although the findings are novel and interesting the following points
need to be addressed:
Major:
1. The title of the manuscript is very broad and should be revised to represent the
key message of the present study more specifically.
2. Please report whether consent of an ethic's commission and of participants
was obtained for this study.
3. The description of the whole population as well as the population identified as
having a risk for ED should be revised, using mean values and SD. Expressions
like "mostly age 25-34 years (29%)" appear partly confusing and are rather
unspecific. Means and SD should also be added to the tables.
4. The following statement needs revision: "Although not statistically significant,
the 15 patients who screened positively for ED risk also reported more active
symptoms by Manitoba index (27% majority with constantly active symptoms,
p=0.386) (Supplementary Table 1)." There is no trend, so an associated between
risk for ED and disease activity should not be concluded. Similarly, in the
discussion this observation should not be described as a trend.
5. Please address the very low specificity of the present model in the limitations.
Please perform additional statistical analyses including additional parameters of
the survey (e.g. race) to identify answer combinations with higher specificity.
Minor:
1. In the supplemental table 1 the last p-value is missing a 0.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
No
Is the presentation of the work clear?
No
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes