Review for 10.1186/s12876-017-0595-8 (2017)

Reviewer ’s report  
 
Title: ANGIOTENSIN II RECEPTOR BLOCKERS AND RISK OF ACUTE PANCREATITIS 
- A POPULATION BASED CASE -CONTROL STUDY IN SWEDEN  
 
Version: 0 Date: 20 Sep 2016  
 
Reviewer: Tianquan Han  
 
Reviewer's report:  
 
The manu by Bexelius et al found that angiotensin II receptor blockers were associated with risk 
of acute pancreatitis for the first time in spite of previ ous cell experiments and animal study.  
The results were obtained from 6161 cases with acute pancreatitis and 61637 controls after 
analysis with multivariable logistic regression which was supported by physiological study (ref 
16) and pathophysiological stu dy (ref 17) and by the study with rat model (ref 18 -20). 
Angiotensin II receptor blockers might be used to treat acute pancreatitis like as somatostatin. 
However, the clinical experience is much important and clinical study should be done before the 
applic ation of angiotensin II receptor blockers for patients with acute pancreatitis.  
                                                                                                            
Major points  
1. The results of retrospective or prospective clinical  trial may be needed to show the efficacy 
of angiotensin II receptor blockers in the treatment of severe and mild acute pancreatitis.  
2. Details on the clinical course in observing the patients are necessary in the study.  
  
Minor points  
1. Only 3 articles are published within the recent 5 years, any more recent references?  
2. The data of references 14, 19, 23 were incomplete.  
3. Reference 19 was in 2010 not in 2009.  
Are the methods appropriate and  well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn ad equately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recomm ended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing inte rests  
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