Review for 10.1186/s12876-023-02730-6 (2023)

Reviewer’s report
Title: 
Impact of comorbidities on hospital mortality in patients with acute
pancreatitis. A population-based study of 110,021 patients
Version: 
0 
Date: 
08 Dec 2022
Reviewer's report:
This is a retrospective observational study aimed at determining the trend in
acute pancreatitis hospital mortality and the role of comorbidities as a predictor
of hospital mortality.
The Authors concluded that advanced age, heart disease, renal disease,
moderate-severe liver disease, peripheral vascular disease, and cerebrovascular
disease before admission were independently associated with hospital mortality.
The Charlson and Elixhauser comorbidity indices are useful for predicting
hospital mortality in AP patients.
The topic is really interesting, although the conclusions were not so new.
However, the paper is a well described picture of a large population. 
It is clear, well written, being clear in the presentation of the contents. 
However, some minor comments need to be made:
- it's not clear to me why the Authors have chosen pancreatic necrosis as one of
the analyzed outcomes, not necessarily being correlated with the severity of
pancreatitis nor having a linear relationship with mortality. Please can the
Authors comment on it?
- The etiology of the pancreatitis was in 44.3% of the cases defined as
"unspecified". This proportion seems quite high, can the Authors describe was
the etiology sought and in how many cases a procedure such as EUS or MRI was
performed to rule out a biliary etiology?
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
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Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes
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