Review for 10.1186/s12876-018-0786-y (2018)

Reviewer ’s report  
 
Title: Mitotic and apoptotic activity in colorectal neoplasia  
 
Version: 1 Date: 02 Apr 2018  
 
Reviewer: Satish Ramalingam  
 
Reviewer's report:  
 
The authors have justified the major and minor  concerns appropriately and the revised 
manuscript is very clearly highlighting the significance of the current manuscript. The New 
figure 3 showing the entire crypt together with luminal surface along with the 400x 
magnification or they can mention the 60 0x covers details in the cryptal orificium. Over all, the 
revised version has addressed all the reviewer's concerns and suitable for publishing.  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
  
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you receiv ed reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests i n relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
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on my report to the authors and, if the manuscript is accepted for publication, my named report  
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to the  editors, which will not be published.  
 
I agree to the open peer review policy of the journal