Review for 10.1186/s12876-020-01470-1 (2020)

Reviewer’ s report
Title: Peptide receptor radionuclide therapy controls inappropriate calcitriol secretion in a
pancreatic neuro-endocrine tumor: a case report.
Version: 0Date: 04 Jun 2020
Reviewer's report:
This is an interesting case-report on a rare condition. However there are a few issues that need to
be addressed.
Major
1. The authors do not clearly describe the relation of calcium levels with each cycle of PRRT (onlymentioning good response at the end of treatment). It would be useful for the authors to add in thegraph with calcium levels, when each cycle of PRRT was administered and comment on thetemporal relationship between cycles and calcium levels.2. How can the authors justify treatment escalation in a patient with a "clear morphologicalresponse" at the end of PRRT? Can they elaborate on this, what do they meen by clearmorphological response, contrast enhanced cross-sectional imaging was not included.3. There is a lot of repetition in the case report, which is overly long/ repetitive. This needs to bemodified
Minor
1. Minor language problems in the text2. Comment page 2 line 40: treatment with PRRT....confirming this uncommon diagnosis. Thisdoes not read well and needs to be more clear.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
YesDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
NoAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Unable to assessAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?
If an additional statistical review is recommended, please specify what aspects require further
assessment in your comments to the editors.
Not relevant to this manuscriptQuality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
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financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?
6. Do you have any non-financial competing interests in relation to this paper?
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If your reply is yes to any, please give details below.
NilReviewer Publication Consent. I agree for my report to be made available under an Open Access
Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manu-script is accepted for publication. Any comments that I do not wish to be included in the publishedreport have been included as confidential comments to the editor, which will not be published.Ifyou are not happy for us to publish this report, please contact the editorial office before completingthe review.If you wish, you can include your name in your published report. Please note you mustdecide whether to include your name at the start of the process and confirm this decision wheneverprompted. If you change your decision later, we will not be able to publish your name.
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