Review for 10.1186/s12876-021-01615-w (2021)

Reviewer’s report
Title: 
Obesity interacts with hyperuricemia on the severity of non-alcoholic fatty
liver disease
Version: 
0 
Date: 
06 Nov 2020
Reviewer: 
Szu-Chia Liao
Reviewer's report:
1. It's subjective that the diagnosis of NAFLD was confirmed by sonography, if
by only one physician. Are there multiple experts' agreement for the sonographic
diagnosis?
2. Chronic liver disease must be excluded in the diagnosis of NAFLD. Please
define "chronic liver disease" in your study.
3. For a cross-sectional study, like yours, it is difficult to make the conclusion for
the relationship between hyperuricemia, obesity and NAFLD. You only could
tell the situation in steatosis of NAFLD in hyperuricemia and obesity patients.
There were many studies talking about the association of hyperuricemia, obesity
and NAFLD, including large cohort study in China (Plos One 2018;
13(2):e0192396). How about the strength in your study?
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes