Review for 10.1186/s12876-022-02201-4 (2022)

Reviewer’s report
Title: 
AL amyloidosis with primary presentation of multiple serous cavity
effusion and severe cholestasis: A case report and review of literature
Version: 
2 
Date: 
17 Jan 2022
Reviewer: 
Tamer Rezk
Reviewer's report:
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Many thanks for your response - as mentioned by other reviewers, the diagnosis
of AL amyloidosis is dependant on CR +ve and IHC to kappa or lambda LC in
the context of a systemic clone. In this case the patient had staining to both
kappa and lambda and this does confirm the diagnosis of AL amyloidosis (likely
lambda in light of the lambda light chain plasma cell dyscrasia detected in the
systemic circulation). Whilst a concurrent BMT would be useful to further
characterise the clonal dycrasia, i note the response to reviewers that the patient
had signficantlly deranged PT (seen in AL Amyloid) and wished for no further
invasive investigations 
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