Review for 10.1186/s12876-022-02169-1 (2022)

Reviewer’s report
Title: 
Submucosal oesophageal squamous cell carcinoma with lymph node
metastasis: A case report and literature review
Version: 
0 
Date: 
13 Mar 2021
Reviewer: 
Szu-Chia Liao
Reviewer's report:
1. In your case, do you perform endoscopic biopsy before ESD?If yes, how
about the result? If no, why? Because esophageal SCC is mostly originated from
mucosa, it is rare originated from submucosa without epithelial involvement.
Therefore, how to make sure the lesion without epithelial involvement only
submucosal lesion without endoscopic biopsy?
2. In your case, you do not mentioned the endoscopy model in your case? n
clinical practice for diagnosis of esophageal cancer, it is not enough only under
white light image. Do you take the picture for the lesion under NBI or
magnification? If not, how could you make sure this is not esophageal cancer
with mucosal lesion and only submucosal involvement?
3. For the pathology of ESD, did esophageal cancer with epithelial involvement
or not?
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