Review for 10.1186/s12876-021-01675-y (2021)

Reviewer’s report
Title: 
Diagnostic accuracy assessment of molecular prediction model for the risk
of NAFLD based on MRI-PDFF diagnosed Chinese Han population
Version: 
0 
Date: 
13 Oct 2020
Reviewer's report:
PEER REVIEWER ASSESSMENTS: 
OBJECTIVE - Full research articles: is there a clear objective that addresses a
testable research question(s) (brief or other article types: is there a clear
objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols)
appropriate for the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor
to allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results
reasonable and not overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work
technically sound? If not, can revisions be made to make the work technically
sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS: 
GENERAL COMMENTS: The comparison between MRI-PDFF possesses the
high accuracy for the NAFLD diagnosis that can be compared to biopsy results.
The accuracy of these scores: 
Fatty liver index (FLI), NAFLD liver fat score
system (NAFLD LFS), and Liver fat (%) in the prediction and diagnosis of
NAFLD in MRI-PDFF diagnosed Chinese Han population has not been reported
before. This study evaluates the accuracy of molecular prediction models Fatty
liver index, NAFLD liver fat score system, and Liver fat (%) in the prediction
and diagnosis of NAFLD in MRI-PDFF diagnosed Chinese Han population.
Scores in the MRI-PDFF diagnostic NAFLD patients in Chinese Han population
is an acceptable sample of patients and controls.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
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Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
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Yes
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from apparent manipulation?
Yes