Review for 10.1186/s12876-020-01247-6 (2020)

Reviewer ’s report  
 
Title: FARKOR: Evaluating the effects of a risk -adapted screening program for familial 
colorectal  cancer in individuals between 25 and 50 years of age in a prospective population -
based  intervention study  
 
Version: 0 Date: 11 Dec 2019  
 
Reviewer: Isabel Portillo  
 
Reviewer's report:  
 
Dear authors,  
 
It is a very interesting study which could give some lights a bout screening in relatives. But it 
is needed to clarify:  
 
- Recruitment are based in insurance companies? Are private?  
- CRC risk (excluded pTis?).  
- Family risk (first degree only?  
- Will you measure non -participants results?  
- Recent diagnosis is not accurate  
- 30% of cases positive in iFOBT is difficult to reach at this age, despite the risk  
 
Thank you for taking into account these considerations.  
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, pl ease specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Unable to assess  
 
Are you able to assess any statistics in the manuscr ipt or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written Engl ish 
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
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an organisation that may in any way gain or lose financially from the publication of 
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5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
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below.  If your reply is yes to any, please give details below.  
 
non confli cts of interest  
 
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