Review for 10.1186/s12876-020-01375-z (2020)

Reviewer’ s report
Title: Endoscopic severe mucosal atrophy indicates the presence of gastric cancer after
Helicobacter pylori eradication -Analysis based on the Kyoto classification
Version: 1Date: 14 May 2020
Reviewer: Abdullah Yeniova
Reviewer's report:
The manuscript titled " Endoscopic severe mucosal atrophy indicates the presence of gastric
cancer after Helicobacter pylori eradication " has been reviewed.The authors aimed to find endoscopic predictor for early gastric cancer after HP eradicationAlthough it was known that HP is one of main risk factor for gastric cancer, patients can bediagnosed with gastric cancer after HP eradicationManuscript's main idea contribute to literature regarding HP and gastric cancer because it is aclinical debate that patients still can be diagnosed even if they had HP eradicationManuscript is suitable for publication after minor revision1)Authors stated that some facts underscore the importance of diagnosing HP infection andassessing the risk of gastric cancer ( page 8 line 20-26). This sentence is little bit confusingbecause before this sentence authors wirote that endoscopic curative resection can be performedfor early gastric cancer. What are the facts that underscore the diagnose of HP and assess the riskgastric cancer. Endoscopic submucosal dissection is a main treatment for early gastric cancer.Authors should explain in detail about this issue or delete this sentence.2) Why authors choose control group from medical routine check up patients. Maybe this selectionmay cause bias because patients who do not suffer from dyspepsia or any gastrointestinal
symptoms may not have gastritis on their esophagogastroduodenoscopy (EGD) and this cause a
diiferent between these groups in mean of total Kyoto risk score.3)The Kimura-Takemoto classification system is not routinely used in western countires andWestern gastroenterologist are not familiar with this classification system. It may be approriate thatauthors will include a table about this sytem4)What is Brinkman index? Authors should include this and explain in material and method
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
YesDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
AcceptableDeclaration of competing interests
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