Review for 10.1186/s12876-018-0772-4 (2018)

Reviewer ’s report  
 
Title: Irinotecan -containing Doublet Treatment versus Irinot ecan Monotherapy as Second -Line 
Choice for Advanced Gastric Cancer  
 
Version: 1 Date: 12 Jan 2018  
 
Reviewer: Bhavana Bhagya Rao  
 
Reviewer's report:  
 
This is a well performed meta -analysis that compar es two commonly employed second line 
therapies for management of advanced gastric cancer.  
 
 
The cumulative results are significant and will be of interest to the readership of this journal.  
 
 
No significant revisions advised.  
 
Minor spelling errors (significan t spelled as dignificant)etc were noted.  
 
 
 
 
Are the methods appropriate and we ll described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequat ely supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended,  please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I recommend additional statistical review  
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
 
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
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organisation that may in any way gain or lose financial ly from the publication of this 
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3. Do you hold or are you currently applying for any patents  relating to the content of the 
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holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of th e above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
'I declare that I have no competing interests'  
 
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I agree to the open peer review policy of the journal