Review for 10.1186/s12876-016-0503-7 (2016)

Reviewer ’s report  
Title : Associations between polymorphisms in folate -metabolizing genes and pancreatic c ancer 
risk in Japanese subjects  
 
Version:  1 Date:  23 Apr 2016  
 
Reviewer:  Sajan  Nagpal  
 
Reviewer's report:  
-Nicely written and seems to have already made satisfactory changes based on other reviewers' 
recommendations.  
-Adds to evide nce on the role of Folate metabolism related genes and their association with 
pancreatic cancer. However, results may not be generalizable in view of limited sample size. 
The authors recognize the need for studies with a larger sample size and appropriatel y 
identify this limitation.  
-Minor grammatical errors that can easily be corrected prior to resubmission.  
e.g Page 4, Line 7. Two variants in the MTHFR, namely C677T (rs1801133) and A1298C 
(rs1801131),HAVE been identified, not has  
has. 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
Yes 
Does the work include the n ecessary controls?  
If not, please specify which controls are required in your comments to the authors.  
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
Yes 
Are you able to assess any s tatistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
I am able to assess the statisti cs 
Quality of written English  
Please indicate the quality of language in the manuscript:  
Acceptable  
Declaration of competing interests  
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1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financial ly from the publication of this 
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2. Do you hold any stocks or shares in an organisation that may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
5. Do you have any other financial competing interests?  
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below. If your reply is yes to any, please give details below.  
I declare that I have no competing interests' below.  
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