Review for 10.1186/s12876-018-0791-1 (2018)

Reviewer ’s report  
 
Title:  IFI16 is involved in HBV -associated acute -on-chronic liver failure inflammation.  
 
Version: 1 Date: 18 Apr 2018 
 
Reviewer:  Arif Cosar  
 
Reviewer’s report:  
 
Thank you very much for this nice study and corrections.  
 
I think it is better now.  
 
But unfortunately  due to study design, it is quite difficult to  understand and read the text, at least 
for me.  
 
 
It needs a few English correction, such as:  
 
page line 
 
4 38 "CARD = C -terminal caspase recruitment domain"? must added  
 
5 27-31 "Our aboratory investigated hasi nvestigated whether IFI16 is expressed in 
PBMCs and livers in CHB and HBV -ACLF patients and whether HBV DNA is 
recognized by IFI16"  ??? 
 
Are the methods appropriate and well  described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an addit ional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
I recommend additional statistical review  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
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1. Have you in the past five years received reimbursements, fees, funding, or sala ry from an 
organisation that may in any way gain or lose financially from the publication of this 
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3. Do you hold or are you currently applying for any patents relating to the content of the 
manuscript?  
 
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holds o r has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
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below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
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