Review for 10.1186/s12876-016-0483-7 (2016)

Reviewer ’s report  
Title:  Useful condition of chromoendoscopy with indigo carmine and acetic acid for ide ntifying 
a demarcation line prior to endoscopic submucosal dissection for early gastric cancer  
 
Version:  0 Date : 03 Apr 2016  
 
Reviewer:  Mohamed  Othman  
 
Reviewer's report:  
This is a propsective study examining the utility of chromoendoscopy prior to ESD in 109 
intramucosal early gastric cance r. The authors found that chromoendoscopy was useful in 
identifying demarcation line in 38.5% of patients only. Flat type tumor and tumor with atrophic 
borders were more likely to benefit from chromoendoscopy  
Major comment:  
The study assessed chromoendosco py alone without the combined use of NBI. It would of been 
useful to include another analysis discussing the combination of chromoendoscopy and NBI 
because this is what we do in the daily practice of ESD.  
 
Minor comments:  
including coulee pictures as an e xample of useful and useless chromoendoscopy is appreciated.  
 
Are the methods appro priate and well described?  
If not, please specify what is required in your comments to the authors.  
Yes 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
Yes 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
Yes 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review is re commended, please specify what aspects require further 
assessment in your comments to the editors.  
I am able to assess the statistics  
Quality of written English  
Please indicate the quality of language in the manuscript:  
Acceptable  
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