Review for 10.1186/s12876-020-01445-2 (2020)

Reviewer’ s report
Title: Type IV choledochal cyst with polycystic kidney disease:A case report
Version: 2Date: 19 Aug 2020
Reviewer's report:The authors have addressed my raised points. To place the criteria and findings in the appropriate
format, I ask them to replace
"According to the ultrasound-based criteria, the presence of more than 3 cysts suggests a diagnosis
of autosomal dominant polycystic kidney disease (ADPKD) for patients with a positive familyhistory younger than 40 years old (see Supplementary Materials) [4]. A renal MRI showing 4 ormore cysts that were at least 1 cm in size in each kidney would be acceptable for the diagnosis ofADPKD. The patient's son (42 years old) had hepatic cysts and more than 4 renal cysts (≥1 cm) ineach kidney on MRI (see Supplementary Materials). Similarly, the patient met the MRI-baseddiagnostic criteria."
with "According to the ultrasound-based criteria, the presence of 3 or more uni- or bilateral renal
cysts is sufficient to establish the diagnosis of autosomal dominant polycystic kidney disease(ADPKD) in individuals with a positive family history of this disease younger than 40 years old(see Supplementary Materials) [4]. A renal MRI showing 4 or more cysts with at least 1 cm in sizein each kidney, in turn, is acceptable for the diagnosis of ADPKD in patients aged 60 years orolder with a positive family history of ADPKD, criteria that were fulfilled by our 65-year-oldpatient. Lastly, the presence of 2 or more cysts with at least 1 cm in each kidney on MRI inindividuals within the age range of 40-59 years and with a positive family history is acceptable to
make the diagnosis of ADPKD, diagnostic criteria that were fulfilled by the 42-year-old patient's
son, who also presented hepatic cysts (see Supplementary Materials)."
And please replace "Heterozygous mutations in GANAB were found in families with autosomal
dominant polycystic kidney or liver disease." with "Heterozygous mutations in GANAB werefound in a minority of families with autosomal dominant polycystic kidney or liver disease."
It is unclear what the authors mean with "GANAB define effectors of PC1 function." I suggest
removing this sentence.
Gene symbols should be in italics.
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Is the study design appropriate to answer the research question (including the use of appropriate
controls), and are the conclusions supported by the evidence presented?
YesAre the methods sufficiently described to allow the study to be repeated?Yes
Is the use of statistics and treatment of uncertainties appropriate?
YesIs the presentation of the work clear?YesAre the images in this manuscript (including electrophoretic gels and blots) free from apparent
manipulation?
Yes