Review for 10.1186/s12876-020-1168-9 (2020)

Reviewer’s report
Title:  High rates of cirrhosis and severe clinical events in patients with HBV/HDV co-infection:
Longitudinal analysis of a German cohort.
Version: 1 Date: 14 Jun 2019
Reviewer: Akihiro Tamori
Reviewer's report:
BMGE-D-18-00611
High rates of cirrhosis and severe clinical events in patients with HBV/HDV co-infection: Longitudinal
analysis of a German real life cohort
Jan-Hendrik Bockmann, MD; Marcel Grube; Vanessa Hamed; Johann von Felden; Johanna Blöcker;
Malte Wehmeyer; Katja Giersch; Michaela Hall; John M. Murray; Maura Dandri; Stefan Lüth; Ansgar
W. Lohse; Marc Lütgehetmann; Julian Schulze zur Wiesch
Thank you for polite replies to my comments.
Just one point is left to be clarified. Clinical outcome depended on both HBV and HDV status. Authors
focused on HDV in the present study. It is necessary to add the information of anti-HBV therapy for
enrolled 49 patients in Methods or Results, and some comments in Discussion.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Unable to assess
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an additional
statistical review?
If  an  additional  statistical  review  is  recommended,  please  specify  what  aspects  require  further
assessment in your comments to the editors.
Not relevant to this manuscript
Quality of written English
Please indicate the quality of language in the manuscript:
Acceptable
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