Review for 10.1186/s12876-020-01455-0 (2020)

Reviewer’ s report
Title: Duodenal major papilla morphology can affect biliary cannulation and complications during
ERCP, an observational study
Version: 0Date: 22 Jul 2020
Reviewer's report:
This manuscript reported the difference in the biliary cannulation rate depending on the
morphology of the duodenal major papilla.Although the results are very clear and well-written, I concern the following points need to beconsidered.
Major points
1) As the authors have mentioned, inter-rater reliability for classifying papilla should be evaluated.I suppose this should improve the quality of the study, even if the parameters in each categorychange.2) The frequency of the pancreatic duct guidewire method seems to be important in consideringthe relationship between biliary cannulation rate and the morphology of the papilla. Pleasemention in table 2.
Minor points
1) The total number of ERCP should be described in Results section.
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Is the study design appropriate to answer the research question (including the use of appropriate
controls), and are the conclusions supported by the evidence presented?
YesAre the methods sufficiently described to allow the study to be repeated?YesIs the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
YesAre the images in this manuscript (including electrophoretic gels and blots) free from apparent
manipulation?
Yes