Review for 10.1186/s12876-022-02632-z (2023)

Reviewer’s report
Title: 
Analysis of related factors of portal vein thrombosis in liver cirrhosis
Version: 
1 
Date: 
27 Nov 2022
Reviewer's report:
The manuscript is interesting and addresses an important aspect of understanding
the pathophysiology of PVT development.
I have a few queries.
- The prevalence of PVT was quite high compared to conventional studies and
my own experience. Was this a special patient population with advanced
cirrhosis ? 
- TNF alfa was found to be lower among PVT patients. It would be interesting to
know what was the time frame between PVT detection and blood sample
collection. Could a varibale time between detection of PVT and blood sample
collection explain the study results?
- How many patients in the two groups were actively drinking alcohol?
- A separate paragraph with limitations should be included and not be mixed up
with conclusions
- Conclusions should be at the end of the manuscript without mention of
limitations.
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paper?
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No conflict
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
No
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes
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No