Review for 10.1186/s12876-016-0550-0 (2016)

Reviewer ’s report  
 
Title: The incidence, presentation, outcomes, risk of mortality and economic data of drug -
induced  liver injury from a national database in Thailand: a population -base study  
 
Version: 0 Date: 29 Aug 2016  
 
Reviewer: Rolf Teschke  
 
Reviewer's report:  
 
A comprehensive study, but with a major flaw.  
 
Major po int: 
Causality assessment such as RUCAM was not done. Please see: Danan G, Teschke R. RUCAM 
in drug and herb induced liver injury: the update. Int J Mol Sci; Special issue: Drug, herb, and 
dietary supplement hepatotoxicity 2016; 17,14. DOI:10.3390/ijms170 10014.  
You quoted the paper of Andrade, wich also used RUCAM.  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
No 
 
Does the work include t he necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
No 
 
Are you  able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Not suitable for publication unless extensively edited  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publi cation of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you curr ently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any  other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I have no conflict of interest.  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
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to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal