Review for 10.1186/s12876-020-01491-w (2020)

Reviewer’s report
Title: 
Adverse events of video capsule endoscopy over the past two decades: a
systematic review and proportion meta-analysis
Version: 
0 
Date: 
14 Aug 2020
Reviewer: 
Marco Pennazio
Reviewer's report:
The authors present a systematic review and meta-analysis of a large number of
studies on the adverse events of capsule endoscopy. The manuscript provides an
important update of useful information for clinical practice 20 years after the
introduction of capsule endoscopy in medical practice. The manuscript is clear
and well written.
I only have two small requests
1) There is a recent meta-analysis on capsule retention, specifically performed in
IBD patients (Pasha S, et al. Inflamm Bowel Dis 2020;26:33-42). In addition to
quote it in the references, the authors should compare and comment the results of
this meta-analysis with the data emerging from their study.
2) on page 21 the authors say "These findings confirm that performing an initial
PCE before VCE is useful to avoid retention". This is indeed true, but in order to
avoid confusion to the reader, I would suggest contextualizing that this approach
should be primarily reserved for patients with a high-risk of capsule retention, of
which those with known IBD are probably the most representative. This in
accordance with the recommendations of the most recent guidelines on the
subject, which I suggest to quote in the references: 
Endoscopy 2015;47: 352-76
& Endoscopy 2018; 50: 423-446
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes