Review for 10.1186/s12876-021-01925-z (2021)

Reviewer’s report
Title: 
Esophageal metastasis of renal cell carcinoma resected by endoscopic
submucosal dissection: a case report
Version: 
1 
Date: 
27 May 2021
Reviewer's report:
Thank you for your submission of an interesting, rare case managed with ESD.
You have flourished the case report with interesting images. 
Below are my comments and suggestions:
Page 3 Line 55 ….9 nine
Suggest to remove the numerical 9
Page 5 Line 76 ….increased 4 years ago…
Unclear statement. 
Does the author refer to the lesion size increased over the past 4 years?
Or 
the lesion noted to be increasing in size 4 years ago during their surveillance
scope?
-if it increased in size 4 years ago, suggest authors to justify the reason biopsy
was not performed; was it because no indication or it appears benign from
endoscopy assessment? This will help the reader to understand the chronology of
the lesion.
Page 6 Line 82 …, and enhanced computed tomography….
Suggest to amend: contrast enhanced computed tomography
Page 7 Line 111-112
This sentence is fragmented and unclear. Suggest to revise.
Page 8 Line 114 As we believe that…..
avoid using "believe"
Suggestion: As the metastatic lesion appeared to be intramucosal from the
endoscopic ultrasound, we decided to perform ESD with adequate margin.
Page 8 Line 119
Avoid usage of the word "believe" in scientific writing
Page 8 Line 124 
Avoid usage of the word "believe" in scientific writing
Page 8 Line 127
Suggest to add subheadings "Conclusion"
Page 12 Line 187 Figure 4
Please use marker or arrows to show the lesions and the layers involved to help
the reader to appreciate it.
Page 12 Line 188 Figure 5A
Please label and show with markers or arrow.
Please indicate the magnification power and the type of stain use for this slide.
Page 12 Line 190 Figure 5B
Please indicate with markers and arrows.
Please indicate magnification and the type of stain use for this slide.
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paper?
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
No
Is the use of statistics and treatment of uncertainties appropriate?
No
Is the presentation of the work clear?
No
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes