Review for 10.1186/s12876-021-01822-5 (2021)

Reviewer’s report
Title: 
Vonoprazan versus lansoprazole in the treatment of artificial gastric ulcers
after endoscopic submucosal dissection: a randomized, open-label trial
Version: 
0 
Date: 
03 Apr 2021
Reviewer's report:
In this study, the authors tried to prove the superiority of vonoprazan to
lansoprazole in the healing rate after gastric ESD. They conducted the
prospective RCT in single center. As a result, vonoprazan was not superior to
lansoprazole in terms of the healing rates and shrinkage rates of artificial gastric
ulcers at 4 and 8 weeks after ESD. Furthermore, there were no significant
differences in the occurrence of postoperative bleeding and delayed perforation
between the two groups. In this study, the sample size did not reach the expected
number of cases, and the interpretation of the results should be limited. However,
the methods and analysis of the study are valid and may be of some value as a
clinical study. I would like to make the following suggestions to make the
manuscript more formally appropriate.
Comments)
1) The indications for ESD for gastric tumors performed in this study should be
described.
2) The patient backgrounds shown in Table 1 were the results after pathological
diagnosis. Diagnosis before being randomized should be also shown. The authors
should describe how the randomization in this study was done.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
No
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes