Review for 10.1186/s12876-021-01694-9 (2021)

Reviewer’s report
Title: 
Endoscopic resections for superficial esophageal squamous cell epithelial
neoplasia: Focus on histological discrepancies between biopsy and resected
specimens
Version: 
1 
Date: 
14 Nov 2020
Reviewer's report:
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The study is focused in histopathological examination. The discrepancy between
biopsy and resected specimens after ESD in diagnosis of intraepithelial
neoplasia and esophageal squamous cell carcinoma was discussed in detail. It is
common knowledge that ESD is the first option for treatment ESCC in selected
cases. 
I propose to supplement the discussion and conculsions;
1. The endoscopic recommendations used in this study. The authors cite the
papers Park CH et al., Pedro Pimentel-Nunes et al, Ishikara R et ( 7, 8 ,9
references) but they don't discuss these criteria. It will be better to define the
recommendations used in this paper.
2. The conclusions are quite simple. It will be better to define two categories of
resected specimens , the first one "indefinite of neoplasia and LGIN" and second
- "HGIN and ESCC ". comparing to the endoscopic recomendation, biopsy and
histopathological findings as degree of neoplasia and histological grade of
esophageal cancer. This conculsions would be a guidelines for ESD.
3. I propose to put histopathological photos of selected cases from biopsy and
ESD specimen.
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Is the study design appropriate to answer the research question (including the use
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