Review for 10.1186/s12876-020-01484-9 (2020)

Reviewer’s report
Title: 
Expression and significance of Her2 and Ki-67 in gastric adenocarcinoma
without distant metastasis: A cohort study
Version: 
1 
Date: 
17 Jul 2020
Reviewer's report:
Comments
1) The authors concluded that strong Her2 expression predicted poor prognosis.
However, it is difficult to accept this conclusion from several results of Figure 3
and Table 7.
2) In Table 7, univariate analysis did not select strong (+++) HER2 expression as
an independent prognostic factor (P=0.467). However, strong (+++) HER2
expression was selected as a prognostic factor in multivariate analysis.
Moreover, multivariate analysis showed that its p-value was 0.047. It is difficult
to understand these results.
3) To date, many investigators have investigated the clinical significance of Her2
expression in patients with gastric cancer. How do the authors discuss about the
novelty of this study?
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No
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I recommend additional statistical review
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Acceptable
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