Review for 10.1186/s12876-021-01713-9 (2021)

Reviewer’s report
Title: 
Expression of Cyr61 is associated with Clinical Course in Patients with
Crohn’s Disease
Version: 
2 
Date: 
26 Dec 2020
Reviewer's report:
I appreciate the efforts of the authors to change the manuscript following my
suggestions. 
The use of CDAI still remains not plausible. However, the paper is significantly
improved.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes