Review for 10.1186/s12876-020-01324-w (2020)

Reviewer’ s report
Title: Nomogram based on blood lipoprotein for estimation of mortality in patients with hepatitis
B virus-related acute-on-chronic liver failure
Version: 1Date: 29 Jan 2020
Reviewer: Jian-Ming Zheng
Reviewer's report:
The study tried to formulate and validate a nomogram model based on blood lipoprotein for
prediction of 3-month mortality in patients with hepatitis B virus (HBV)-related ACLF. It is aninteresting study. MAJOR COMMENTS 1. INR is different in development group and validationgroup. It may indicate that development group and validation group are not comparable. Are theMELD scores of the two groups comparable? 2. The authors did not select these parameters, suchas sodium, HBeAg status, HBV DNA level and antiviral drug, could affect the prognosis ofpatients with HBV-related ACLF, to construct the nomogram in the present study. However, theseimportant parameters may be provided in the baseline characteristics. 3. The conclusions of thisstudy is that reduction of serum LDLC level was an independent risk factor for the survival inpatients with HBV-related ACLF. Is it confirmed serum LDLC level was an independent riskfactor by multivariate analysis?
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I recommend additional statistical review
Quality of written English
Please indicate the quality of language in the manuscript:
AcceptableDeclaration of competing interests
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