Review for 10.1186/s12876-021-01947-7 (2021)

Reviewer’s report
Title: 
A rare case of Benign Multicystic Peritoneal Mesothelioma misdiagnosed
as hydatid cyst found in the liver parenchyma and abdomen cavity of a male
with asbestos exposure.
Version: 
0 
Date: 
03 May 2021
Reviewer's report:
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The authors report a case of benign multicystic mesothelioma of the peritoneum
misdiagnosed as an hydatid cyst.
This is an intersting differential diagnosis to explore when dealing with the
diagnosis of benign multicystic peritoneal mesothelioma in this location. 
The case report should be improved by the authors evaluating additional
immunohistochemical biomarkers such as the calretinin and WT1 for checking
mesothelial origin of the cells lining the cysts. D240 is a marker useful in such
situtation with CD34 to explore the lymphatic lineage of the cells for the
differential between mesothelial and endothelial cells lining lymphatics. The
authors shoud better clarify the algorithm used to obtain the final diagnosis.
The authors should improve the text with additional laboratory tests for
exploring the hypothesis of hydatid cysts and also a comparative analysis of the
caracteristics of imaging would be interesting to know for the reader. To
improve the interest of the case report the differential diagnosis should be
expanded
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
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Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
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