Review for 10.1186/s12876-021-01842-1 (2021)

Reviewer’s report
Title: 
Pancreaticopleural Fistula in a Child with Chronic Pancreatitis Harboring
Compound SPINK1 Variants
Version: 
2 
Date: 
27 Apr 2021
Reviewer's report:
REVISION ASSESSMENT FROM THE ACADEMIC PEER REVIEWER: 
Has the author addressed your concerns sufficiently for you to now recommend
the work as a technically sound contribution? Yes
Reviewer comments: HAVE THE AUTHORS RESPONDED ADEQUATELY
TO EACH OF THE QUESTIONS YOU RAISED IN YOUR COMMENTS
Yes thank you authors
HAVE THEY MADE THE APPROPRIATE CHANGES IN THE
MANUSCRIPT 
Yes they have 
WHAT IS YOUR OVERALL IMPRESSION OF THE REVISED
MANUSCRIPT 
This is an interesting case in a young person 8yo) using endoscopic
interventional 
treatment to "seal" the PPF. This treatment is not common in
pediatric patients and thus would support publication.
ARE THERE ANY ADDITIONAL REVISIONS THE AUTHORS SHOULD
MAKE
1. Line 23 add the phrase " a genetic mutation involving" after the word "from"
2. line 47 acute respiratory distress really suggests something else I would delete
it as a pleural manifestation of CP or PPF a PPF will lead to respiratory
difficulties but not as an acute event 
3. Line 50 I would add the word "necrotizing" before reword "pancreatitis" I
would doubt that the incidence is even as great as 0.4% as a true PPF
4. Lines 77 and 78. What was the amylase activity of the pleural fluid? 
Was it
measured?
5. Line 118 and 119. Wasn't 
there also a pseudocyst in the mediastinum which
communicated with the pancreatic ductal rupture as shown in figure 4 b and c
the actual fistula arose from the pseudocyst 
6. Line 143. This incidence is too high for ALL patients with CP I tho I you
mean in patients with idiopathic CP
7. Line 152. 
I really think that you should add the phrase. "a pseudocyst and/or"
after the word "of"
8. Figure 1 legend change calcified to calcification 
9. Figure 4 I would suggest that you change to
He figure legend to "demonstrate a mediastinal pseudocyst and presumed PPF
arising from"
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