Review for 10.1186/s12876-021-01756-y (2021)

Reviewer’s report
Title: 
Characterization of novel and large fragment deletion s  in exon 1 of the
IL10RA 
 gene in Chinese children with very early onset inflammatory bowel
diseases
Version: 
2 
Date: 
05 Mar 2021
Reviewer's report:
Please correct definition of Very early onset IBD (VEOIBD), which represents
children diagnosed prior to 6 years of age /Uhlig HH et al. Gastroenterology.
2014;147(5):990-1007.e3. doi:10.1053/j.gastro.2014.07.023/
Please add clear information in Method section who was included in the control
group 
Table 3. 
is not mentioned in the manuscript text - please correct that
It would be valuable to add discussion about similarities/differences between
patients with large deletions in Exon1 comparing with other patients 
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes