Review for 10.1186/s12876-018-0841-8 (2018)

Reviewer ’s report  
 
Title: Variables affecting penetrance of gastric and duodenal phenotype in familial adenomatous 
polyposis patients  
 
Version: 0 Date: 02 Apr 2018  
 
Reviewer: Ian Roberts -Thomson  
 
Reviewer's report:  
 
1. It may be helpful to modify the Abstract to indicate that patients with classical FAP have 
more duodenal aden omas than those with attenuated FAP. Currently, the Abstract only 
indicates that the burden of duodenal adenomas is different in the two groups. Otherwise, no 
other comments.  Ease include all comments for the authors in this box rather than uploading 
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Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
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Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or  would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I recommend additional statistical review  
 
  
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimburs ements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial com peting interests in relation to this paper?  
 
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below.  If your reply is yes to any, please give details below.  
 
A worthwhile addition to the substantial literature on FAP. The statistical methods seem 
satisfactory but I do not claim any special expertise in this area. I have no competing interests in 
this area.  
 
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I agree to the  open peer review policy of the journal