Review for 10.1186/s12876-020-01278-z (2020)

Reviewer’ s report
Title: Association between NAFLD and risk of prevalent chronic kidney disease: Why there is a
difference between East and West?
Version: 0Date: 07 Feb 2020
Reviewer: Rosa Filiberti
Reviewer's report:
The authors used datasets from a Western and a Eastern population to clarify the association
between NAFLD and CKD. They concluded that NAFLD increases the risk of early stages CKDin both populations, while a significant association was found only for Chinese people whenconsidering all stages of CKD.I think that the use of different non standardized datasets, mainlythe difference in the considered period (1984 to 1994 for China and 2010 for USA) may haveinfluenced results. The authors should discuss better the limits of the study given also the fact thatthey compared two populations with large differences in lyfestile and dietary habits (see forexample the difference in definition of excessive alchool intake between the two groups).The textcontains some errors (ie Model 1 and Model 1)Table 3 is misleading. It should be better to add amore detailed title (i.e. Odds Ratios for Associations Between NAFLD and Risk of CKD)
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
No
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Unable to assessAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
NoAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statisticsQuality of written English
Please indicate the quality of language in the manuscript:
Acceptable
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