Review for 10.1186/s12876-022-02347-1 (2022)

Reviewer’s report
Title: 
Comparative Efficacy and Safety of Infliximab and Vedolizumab Therapy
in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-
analysis
Version: 
0 
Date: 
09 Mar 2022
Reviewer's report:
Congratulations to the authors for this excellent work comparing with meta-
analytic strategy the efficacy and safety of IFX and VDZ in patients with
moderate-to-severe CD or UC. The methodological exposition of the meta-
analysis is appropriate and timely. Study selection is presented in accordance
with PRISMA and risk of bias and generalizability assessment using Cochrane
Handbook criteria. The discussion is organic and structured well. The tables are
excellent as are the figures. I recommend acceptance of the manuscript for
publication.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
Yes
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes