Review for 10.1186/s12876-021-02076-x (2022)

Reviewer’s report
Title: 
A Large Undifferentiated Sarcoma of the Liver in a 13-year-old Girl Treated with Anatomical
Resection: A Case Report and Review of the Literature
Version: 
0 
Date: 
29 Sep 2021
Reviewer's report:
This case report is interesting because although the tumor is very large, it has a long prognosis of 6 years
after only surgical resection, but it also has points that need to be clarified. For example, whether UES in
this case has developed on the background of an underlying benign tumor such as mesenchymal
hamartoma.
This report lacks detailed histopathological features of the tumor such as;
1. Gross definition.
2. Better definition of the cellular and stromal characteristics of the tumor.
3. Immunohistochemical features such as Vimentin, cytokeratin and Ki-67 expression in the tumor cells.
4. Prognostic features; Presence or absence of lymphovascular invasion and satellite nodules, and lymph
node status, .
5. Histopathological differential diagnosis from embryonal rhabdomyosarcoma, hepatocellular adenoma,
sarcomatoid HCC.
Figure 3.B Probably represents a Periodic acid- Schiff after diastase (dPAS) instead of Periodic acid-
Schiff (PAS) stain.
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Is the study design appropriate to answer the research question (including the use of appropriate controls),
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Yes
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No
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