Review for 10.1186/s12876-017-0680-z (2017)

Reviewer ’s report  
 
Title: Fast food diet -induced non -alcoholic fatty liver disease exerts early protective effect 
against acetaminophen intoxication in mice  
 
Version: 0 Date : 26 Aug 2017  
 
Reviewer: Quirino Lai  
 
Reviewer's report:  
 
This is an interesting basic -science article coming from Korea focused on the role of 
acetaminophen in inducing acute liver toxicity in a population of mice having non -alcoholic fatty 
liver disease vs. a control group with normal liver.  
Study results show that NAFLD presents a protecti ve role against the risk of acetaminophen -
induced acute liver toxicity.  
The study is well written and the methodology is correctly performed. The study is innovative. I 
only suggest the Authors to report across the text (I suggest in Material and methods)  how many 
mice were enrolled in the 4 groups. It is possible to obtain such an information from Tables 1 
and 2, but I think it is more correct to add a sentence clearly reporting the texted sample size also 
in the text.  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
No 
 
Does the work include the nece ssary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any  statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the stati stics 
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past fiv e years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that ma y in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, f unding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
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