Review for 10.1186/s12876-022-02348-0 (2022)

Reviewer’s report
Title: 
Utility of mean platelet volume in differentiating intrahepatic
cholangiocarcinoma from hepatocellular carcinoma
Version: 
0 
Date: 
11 Jan 2022
Reviewer's report:
This manuscript ,,Utility of mean platelet volume in differentiating IHCC from
HCC'' is well written and interesting. However there are some drawbacks, firstly
In the abstract section conclusion is too bold, since this is not novel tumor
marker, nor it can be used solely in differentiation of IHCC from HCC. Why did
authors choose MVP solely? Did they considered other parameters of systemic
inflammation? Were patients received treatment of Hep B or Hep C prior to
inclusion in the study? And if so which treatment did they receive? Considering
the retrospective side of the study did the patients receive ribavirin and IFN,
since it could affect platelets. Why did the authors did multivariate analysis and
not logistic regresion in univariate analysis? Did the authors analysed model they
provided in logistic regression? What were the cut-off values of MVP included
in the model?
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Is the study design appropriate to answer the research question (including the use
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