Review for 10.1186/s12876-020-01446-1 (2020)

Reviewer’ s report
Title: Gastric submucosal abscess caused by Edwardsiella tarda infection: a case report
Version: 1Date: 25 Jul 2020
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This is very rare and valuable case. However, it contains several problems as listed below.Major comments
1.This case was initially diagnosed as gastric submucosal abscess, but I believed this case to beextrinsic compression of the stomach after carefully reviewing the case report. If this case wasgastric submucosal abscess, images would be required for diagnoses. For example, endoscopicfindings are recommended to suggest by changing the condition of air inflation of stomach, orobserving the presence or absence of cushion sign. In EUS, the authors need to identify thesubmucosal layer and proper mucosal layer by using an arrow (as shown).2.Was a bile culture taken during ERCP？ If the bile culture was taken, it is clear that intra-
abdominal abscess and cholangitis were related.3.It was mentioned that "Fistulography showed connection between the intra-abdominal abscessand gastric submucosal abscess.", but why was drainage not performed? Was a larger sizepercutaneous tube used?
4.In discussion, it was mentioned that "infection route is direct infection to the gastric wall.", but
please explain the above.
Minor comments
1.Isn't it rare that cholangitis causes an intra-abdominal abscess? If so, it need to be discussed inthe discussion session.2.It was mentioned that "Figure 2. Endoscopic and endoscopic ultrasound findings" in Figurelegends, but fistulography is also recommended to include.
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Is the study design appropriate to answer the research question (including the use of appropriate
controls), and are the conclusions supported by the evidence presented?
No
Are the methods sufficiently described to allow the study to be repeated?YesIs the use of statistics and treatment of uncertainties appropriate?Yes
Is the presentation of the work clear?
NoAre the images in this manuscript (including electrophoretic gels and blots) free from apparent
manipulation?
Yes