Review for 10.1186/s12876-020-01437-2 (2020)

Reviewer’ s report
Title: A novel predictive model based on inflammatory markers to assess the prognosis of patients
with HBV-related acute-on-chronic liver failure:a retrospective cohort study
Version: 3Date: 06 Aug 2020
Reviewer's report:
This is an interesting study.
However, some study limitations should be listed.First, the patient selection bios ( enrolled in the ward of infectious department, no patients needdialysis or mechanical ventilation) should be mentioned in the limitation part of this article.Second, several scoring systems for predicting mortality of patients with ACLF should bementioned in this study. If it is difficult for performing these scores in this study (due to theretrospective study design), please list that in the limitation part of this article.
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NoDeclaration of competing interests
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(default)
Is the study design appropriate to answer the research question (including the use of appropriate
controls), and are the conclusions supported by the evidence presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?YesIs the use of statistics and treatment of uncertainties appropriate?YesIs the presentation of the work clear?YesAre the images in this manuscript (including electrophoretic gels and blots) free from apparent
manipulation?
Yes