Review for 10.1186/s12876-022-02618-x (2023)

Reviewer’s report
Title: 
Establishment and Evaluation of an Early Prediction Model of
Hepatorenal Syndrome in Patients with Decompensated Hepatitis B Cirrhosis
Version: 
0 
Date: 
07 Jun 2022
Reviewer's report:
Wang et al. ealuated an early prediction model of hepatorenal syndrome in
patients with decompensated hepatitis B cirrhosis using three parameters: total
bilirubin, hemoglobin, and serum creatinine. Several issues should be further
clarified.
1. How could the patients provide informed consent in a retrospective study?
2. Please explain the inclusion criteria (7) complikance with HRS diagnostic
criteria.
3. The proportion of pateints on diuretics and with variceal bleeding or bacterial
infection such as SBP should be presented in Table 1.
4. Why the authors include PT in the logistic regression analysis instead of PT-
prolonged?
5. The time from enrollment to occurrence of HRS should be presented.
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Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
No
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Yes
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from apparent manipulation?
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