Instruction:
What is the largest city in Ecuador by population?

Response:
Guayaquil, officially Santiago de Guayaquil, is the largest city in Ecuador by population and the nation's economic capital and main port. The city is the capital of Guayas Province and the seat of Guayaquil Canton. The city is located on the west bank of the Guayas River, which flows into the Pacific Ocean at the Gulf of Guayaquil.