Question: what is the most powerful weapon in supernatural?
Answer: 1 Death's Scythe. To date, this is the only weapon that has proven its full worth and is confirmed to be able to kill anything. 2 The Equalizer. ...  3 Dean Winchester. ...  4 The Colt. ...  5 The First Blade. ...  6 Archangel Blades. ...  7 Hands Of God. ...  8 Lance Of Michael. ...