Question: how long do you cook a whole chicken in the oven at 375?
Answer: 2-1/2 to 3 pounds: Roast at 375 degrees F for 1 to 1-1/4 hours. 3 to 3-1/2 pounds: Roast at 375 degrees F for 1-1/4 to 1-1/2 hours. 3-1/2 to 4 pounds: Roast at 375 degrees F for 1-1/4 to 1-3/4 hours. 4-1/2 to 5 pounds: Roast at 375 degrees F for 1-1/2 to 2 hours.