Question: what is the most significant risk factor for endometrial ca?
Answer: Obesity. Things that affect hormone levels, like taking estrogen after menopause, birth control pills, or tamoxifen; the number of menstrual cycles (over a lifetime), pregnancy, certain ovarian tumors, and polycystic ovarian syndrome (PCOS) Use of an intrauterine device (IUD) Age. Diet and exercise. Type 2 diabetes.