Title: Feline hyperesthesia syndrome

{{short description|Collection of neurological symptoms in domestic cats}}
{{Use dmy dates|date=July 2020}}
{{Infobox medical condition
| name      = Feline hyperesthesia syndrome
| image     = Hannibal Poenaru - Nasty cat ! (by-sa).jpg
| alt       = 
| caption   = Domestic cat showing signs of aggression
| treatment = Behavioural adaptation, pharmaceuticals and alternative medicine.
| symptoms  = Frantic scratching, biting or grooming of tail and lower back; aggression towards other animals, humans and itself; and a rippling or rolling of the dorsal lumbar skin.
| onset     = Around 9–12 months, or when the cat reaches maturity.
| prognosis = Good, provided the cat doesn't self-mutilate excessively.
| duration  = The syndrome will remain present for the cat's entire life, but episodes only last for one to two minutes.
| synonym   = &quot;Feline hyperaesthesia syndrome&quot;, &quot;apparent neuritis&quot;, &quot;atypical neurodermatitis&quot;, &quot;psychomotor epilepsy&quot;, &quot;pruritic dermatitis of Siamese&quot;, &quot;rolling skin syndrome&quot;, &quot;twitchy skin disease&quot;, and &quot;twitchy cat disease&quot;.
}}

First reported in 1980 by J. Tuttle in a scientific article, '''feline hyperesthesia syndrome''', also known as '''rolling skin disease''', is a complex and poorly understood [[syndrome]] that can affect [[Cat|domestic cats]] of any age, [[breed]], and [[sex]].&lt;ref name=&quot;:0&quot;&gt;{{Cite web|title=Hyperesthesia Syndrome|url=https://www.vet.cornell.edu/departments-centers-and-institutes/cornell-feline-health-center/health-information/feline-health-topics/hyperesthesia-syndrome|date=2017-10-16|website=Cornell University College of Veterinary Medicine|language=en|access-date=2020-05-31}}&lt;/ref&gt;&lt;ref name=&quot;:1&quot;&gt;{{cite journal | vauthors = Amengual Batle P, Rusbridge C, Nuttall T, Heath S, Marioni-Henry K | title = Feline hyperaesthesia syndrome with self-trauma to the tail: retrospective study of seven cases and proposal for an integrated multidisciplinary diagnostic approach | journal = Journal of Feline Medicine and Surgery | volume = 21 | issue = 2 | pages = 178–185 | date = February 2019 | pmid = 29595359 | doi = 10.1177/1098612X18764246 | pmc = 10814607 | hdl = 20.500.11820/f5c2d14d-c09e-487b-8736-e97500d028eb | s2cid = 4389341 | hdl-access = free }}&lt;/ref&gt;&lt;ref name=&quot;:2&quot;&gt;{{cite book |last=Barone |first=Georgina |title=The Cat: Clinical Medicine and Management |date=2012 |publisher=Elsevier |isbn=978-1-4377-0660-4 |pages=734–767 |language=en |chapter=Neurology |journal=The Cat |doi=10.1016/b978-1-4377-0660-4.00027-2 |pmc=7152473 |name-list-style=vanc}}&lt;/ref&gt;&lt;ref name=&quot;:3&quot;&gt;{{Cite book |title=Blackwell's five-minute veterinary consult. Canine and feline| first1 = Larry P. | last1 = Tilley | first2 = Francis W. K. | last2 = Smith | date = 29 September 2015 | name-list-style = vanc |isbn=978-1-118-88161-3|edition=Sixth|location=Ames, Iowa|oclc=911135227}}&lt;/ref&gt;&lt;ref name=&quot;:4&quot;&gt;{{cite journal | vauthors = Virga V | title = Behavioral dermatology | journal = Clinical Techniques in Small Animal Practice | volume = 19 | issue = 4 | pages = 240–9 | date = November 2004 | pmid = 18371321 | doi = 10.1053/j.ctsap.2004.10.006 }}&lt;/ref&gt; The syndrome may also be referred to as feline hyperaesthesia syndrome, apparent neuritis, atypical neurodermatitis, psychomotor epilepsy, pruritic dermatitis of [[Siamese cat|Siamese]], rolling skin syndrome, and twitchy cat disease.&lt;ref name=&quot;:1&quot; /&gt;&lt;ref name=&quot;:3&quot; /&gt;&lt;ref name=&quot;:5&quot;&gt;{{cite journal | vauthors = O'Leary DJ | title = A swallowed needle in a cat treated for feline hyperaesthesia syndrome | journal = Acupuncture in Medicine | volume = 33 | issue = 4 | pages = 336–7 | date = August 2015 | pmid = 25987646 | doi = 10.1136/acupmed-2015-010807 | s2cid = 32917950 }}&lt;/ref&gt;&lt;ref name=&quot;:6&quot;&gt;{{Cite web|title=Feline hyperesthesia in cats {{!}} Vetlexicon Felis from Vetstream {{!}} Definitive Veterinary Intelligence|url=https://www.vetstream.com/treat/felis/diseases/feline-hyperesthesia|website=www.vetstream.com|access-date=2020-05-31}}&lt;/ref&gt; The syndrome usually appears in cats after they've reached [[Adult|maturity]], with most cases first arising in cats between one and five years old.&lt;ref name=&quot;:0&quot; /&gt;&lt;ref name=&quot;:1&quot; /&gt;&lt;ref name=&quot;:3&quot; /&gt;

The condition is most commonly identified by frantic scratching, biting or grooming of the [[lumbar]] area, generally at the base of the tail, and a rippling or rolling of the [[dorsal (anatomy)|dorsal]] lumbar skin.&lt;ref name=&quot;:0&quot; /&gt;&lt;ref name=&quot;:1&quot; /&gt;&lt;ref name=&quot;:2&quot; /&gt;&lt;ref name=&quot;:3&quot; /&gt;&lt;ref name=&quot;:4&quot; /&gt;&lt;ref name=&quot;:5&quot; /&gt;&lt;ref name=&quot;:6&quot; /&gt;&lt;ref name=&quot;:7&quot;&gt;{{cite journal | vauthors = Pakozdy A, Halasz P, Klang A | title = Epilepsy in cats: theory and practice | journal = Journal of Veterinary Internal Medicine | volume = 28 | issue = 2 | pages = 255–63 | date = 2014-01-17 | pmid = 24438024 | pmc = 4857998 | doi = 10.1111/jvim.12297 }}&lt;/ref&gt; These [[Medical sign|clinical signs]] usually appear in a distinct episode, with cats returning to normal afterwards. During these episodes, affected cats can be extremely difficult to distract from their behaviour, and often appear to be absent-minded or in a trance-like state.&lt;ref name=&quot;:3&quot; /&gt;&lt;ref name=&quot;:4&quot; /&gt; Overall, the [[prognosis]] for the syndrome is good, so long as the syndrome does not result in excessive self-aggression and self-[[mutilation]] that may lead to infection.&lt;ref name=&quot;:0&quot; /&gt;

==Clinical signs==
Feline hyperesthesia syndrome affects the [[Endocrine system|endocrine]] system, [[Nervous system|nervous]] system, neuromuscular system, and exocrine system. Cats affected by the condition may display a variable number of clinical signs based on the underlying cause.&lt;ref name=&quot;:3&quot; /&gt; Clinical signs include aggression towards people; aggression towards animals; self-aggression; [[Mydriasis|dilated pupils]]; salivation; vocalisation; uncontrolled urination; excessive grooming, particularly of the lumbar region; tail chasing; tail mutilation, caused by scratching and biting of the lumbar region and tail; frantic running and jumping; and a rippling or rolling of the skin in the dorsal lumbar area.&lt;ref name=&quot;:0&quot; /&gt;&lt;ref name=&quot;:1&quot; /&gt;&lt;ref name=&quot;:2&quot; /&gt;&lt;ref name=&quot;:3&quot; /&gt;&lt;ref name=&quot;:4&quot; /&gt;&lt;ref name=&quot;:5&quot; /&gt; Additionally, [[hallucination]]s and behaviour similar to [[Estrous cycle|oestrus]], commonly referred to as heat, have been observed and were reported in the first article on the syndrome in 1980.&lt;ref name=&quot;:1&quot; /&gt;&lt;ref name=&quot;:4&quot; /&gt;

Clinical signs will generally present themselves in brief episodes of one to two minutes.&lt;ref name=&quot;:0&quot; /&gt; After such episode, the cat will generally return to its normal behaviour.&lt;ref name=&quot;:3&quot; /&gt;&lt;ref name=&quot;:4&quot; /&gt; These episodes can occur multiple times per day or per week, and may be triggered by [[Endogeny (biology)|endogenous]] or [[Exogeny|exogenous]] stimuli.&lt;ref name=&quot;:4&quot; /&gt;

The rolling of the dorsal, lumbar region of skin is instigated by the skeletal muscle (cutaneous trunci). This muscle is located directly under the skin and is hyperresponsive when scratched, which thereby causes the rippling effect. It has been noted, however, that the rolling of the skin, among other clinical signs, can occur spontaneously, whether this is a direct result of the syndrome or a result of muscle memory being activated by sensations caused by the syndrome has yet to be determined.&lt;ref name=&quot;:0&quot; /&gt;

==Cause==
The causes of feline hyperesthesia syndrome are highly disputed, largely due to the unknown [[pathophysiology]] of the syndrome and the variation in responses to different treatment methods.&lt;ref name=&quot;:0&quot; /&gt;&lt;ref name=&quot;:2&quot; /&gt;&lt;ref name=&quot;:3&quot; /&gt;&lt;ref name=&quot;:7&quot; /&gt; There are three main theories on the cause of the syndrome, as outlined below:

The first theory suggests feline hyperesthesia syndrome is a [[Emotional and behavioral disorders|behavioural disorder]], which is caused by either behavioural displacement or stress factors. Stress increases the release of [[Alpha-Melanocyte-stimulating hormone|[alpha]-melanocyte-stimulating hormone]] and causes increased grooming and [[Endorphins|endorphin]] production.&lt;ref name=&quot;:1&quot; /&gt;&lt;ref name=&quot;:3&quot; /&gt;&lt;ref name=&quot;:4&quot; /&gt;&lt;ref name=&quot;:5&quot; /&gt; [[Displacement activity|Behavioural displacement]] would occur when a cat experiences an overwhelming impulse to complete two or more unrelated behaviours simultaneously; this may lead to the cat completing a third and often unrelated activity, such as grooming. If this displacement behaviour continues for a prolonged period, it may result in the cat developing a [[Compulsive behavior|compulsive behaviour]] disorder that would no longer be reliant on the original competing behavioural motivations. Excessive grooming and self-mutilation are recognised signs of obsessive compulsive disorder, lending credence to the overall idea that the syndrome is a behavioural disorder, but also supporting the third main theory that is mentioned later.&lt;ref name=&quot;:5&quot; /&gt; It has been noted that affected cats tend to be dominating rather than submissive; some research argues that feline hyperesthesia syndrome is a form of conflict displacement, rather than just a form of general behavioural displacement, wherein the affected cat acts out thwarted territorial disputes on its own body.&lt;ref&gt;{{cite book | first = Eric | last = Hollander | name-list-style = vanc |title=Obsessive-compulsive disorders: diagnosis, etiology, treatment|url=https://books.google.com/books?id=ydZAKVnkVHMC&amp;pg=PA121|pages=121|year=1997|publisher=Informa Health Care|isbn=0-8247-9856-2|author2=Dan J. Stein}}&lt;/ref&gt; The overall theory that feline hyperesthesia syndrome is a behavioural disorder is disputed on the basis of the variability of responses within affected cats to behaviour modification and [[psychoactive drug]]s, as a purely behavioural syndrome would be expected to enter remission after the application of the aforementioned therapeutic treatments.&lt;ref name=&quot;:1&quot; /&gt;&lt;ref name=&quot;:5&quot; /&gt;

The second theory proposes that the syndrome is a [[Epilepsy|seizure disorder]], and that episodes of vocalisation, wild running, jumping, uncontrolled urination, and tail-chasing are instances of epileptic activity.&lt;ref name=&quot;:0&quot; /&gt;&lt;ref name=&quot;:1&quot; /&gt;&lt;ref name=&quot;:2&quot; /&gt;&lt;ref name=&quot;:3&quot; /&gt;&lt;ref name=&quot;:7&quot; /&gt;&lt;ref name=&quot;Pinney&quot;&gt;{{cite book | first = Chris C. | last = Pinney | name-list-style = vanc |title=The Complete Home Veterinary Guide|url=https://books.google.com/books?id=NQa8emazIIIC&amp;pg=PA351|pages=351–352|year=2003|publisher=McGraw-Hill Professional|isbn=0-07-141272-7}}&lt;/ref&gt; This theory is supported by reports of cats showing signs of epileptic seizures after an attack, with dilated pupils and dazed and absent behaviour.&lt;ref name=&quot;:0&quot; /&gt;&lt;ref name=&quot;:1&quot; /&gt;&lt;ref name=&quot;:2&quot; /&gt;&lt;ref name=&quot;:3&quot; /&gt; Use of [[Anticonvulsant|antiepileptic drugs]] achieves a partial response in some affected cats; however, affected cats generally rely on a mixture of therapeutic treatments to combat all clinical signs.&lt;ref name=&quot;:1&quot; /&gt;&lt;ref name=&quot;:2&quot; /&gt;&lt;ref name=&quot;:3&quot; /&gt; This theory is disputed on account of there being variable responses within affected cats to the antiepileptic drugs used for treatment and a lack of known neurological cause with no evidence having been found to demonstrate [[Cranial cavity|intracranial]] or extracranial causes of epilepsy.&lt;ref name=&quot;:2&quot; /&gt;

The final theory of the three main theories is that the syndrome is not a distinct entity, but a conglomerate of unique behaviours caused by a variety of environmental and behavioural factors.&lt;ref name=&quot;:4&quot; /&gt; This theory is supported by the variability of clinical signs within affected cats, with many of the clinical signs being present within other feline disorders including dermatological, behavioural, orthopaedic and neurological disorders. Further support of this theory is provided by the mixed response to a wide range of therapeutic treatment. Overall, however, a consensus on the validity of this theory has not yet been reached.&lt;ref name=&quot;:1&quot; /&gt;&lt;ref name=&quot;:2&quot; /&gt;&lt;ref name=&quot;:3&quot; /&gt;&lt;ref name=&quot;:4&quot; /&gt;

Currently, it is unknown whether there is any [[Genetics|genetic]] link to the disease. Although any age, breed, or sex of cat can develop feline hyperesthesia syndrome, it has been noted that Abyssinian, Burmese, Himalayan and Siamese breeds appear to have an increased risk of developing the disease, therefore there is the possibility of a genetic link.&lt;ref name=&quot;:0&quot; /&gt;&lt;ref name=&quot;:2&quot; /&gt;&lt;ref name=&quot;:3&quot; /&gt;&lt;ref name=&quot;:8&quot;&gt;{{citation|last=Dewey|first=Curtis W. |name-list-style = vanc |title=A practical guide to canine and feline neurology|url=https://books.google.com/books?id=UmwHXXXzskgC&amp;pg=PA442|pages=442|year=2003|publisher=Wiley-Blackwell|isbn=0-8138-1249-6}}&lt;/ref&gt;

It has also been observed that injury could be a predisposing factor of feline hyperesthesia syndrome. However, because injuries affect cats in numerous ways, increasing their stress and anxiety as well as affecting their physical well-being, this knowledge does not settle the debate on whether the condition is behavioural, epileptic or an umbrella term for several underlying conditions.&lt;ref name=&quot;:5&quot; /&gt;

In regards to the early theories, some consider tail mutilation to be associated with neuropathic pain rather than a direct clinical sign of feline hyperesthesia syndrome. This would be the case if feline hyperesthesia syndrome causes [[allodynia]], a painful reaction to stimuli that should otherwise not cause pain, or [[alloknesis]], where stimuli cause a [[Pruritus|pruriceptive]] sensation, commonly known as an itch, where the stimuli otherwise would not.&lt;ref name=&quot;:1&quot; /&gt; It is notable when considering this theory, that some cats have been known to obsessively lick the base of their tail, rather than scratching or biting, which may suggest they're not feeling pain or pruritus, but rather an overwhelming compulsive motivation.&lt;ref name=&quot;:0&quot; /&gt;&lt;ref name=&quot;:2&quot; /&gt;&lt;ref name=&quot;:3&quot; /&gt;&lt;ref name=&quot;:4&quot; /&gt; It has, however, been hypothesised that due to itch and pain receptors sharing peripheral and central nervous system pathways, underlying pain may result in the excessive grooming described.&lt;ref name=&quot;:5&quot; /&gt; Regardless of whether an affected cat demonstrates grooming or self-mutilating behaviours, they all tend to run around frantically following the completion of the activity.&lt;ref name=&quot;:0&quot; /&gt;&lt;ref name=&quot;:2&quot; /&gt;

== Diagnosis ==
Diagnosing cats with feline hyperesthesia syndrome is extremely complicated. The lack of pathophysiological knowledge requires the syndrome to be diagnosed by eliminating other possible causes of clinical signs.&lt;ref name=&quot;:0&quot; /&gt;&lt;ref name=&quot;:3&quot; /&gt; This is a time-consuming and often expensive process that most pet-owners opt-out of, choosing instead to treat the behaviours and symptoms with a variety of therapeutic trials without a definitive diagnosis.&lt;ref name=&quot;:1&quot; /&gt;&lt;ref name=&quot;:5&quot; /&gt;

Many of the behaviours associated with feline hyperesthesia syndrome resemble or are identical to behaviours observed in other feline health disorders; for instance, there is significant overlap between psychogenic alopecia and feline hyperesthesia syndrome.&lt;ref name=&quot;:0&quot; /&gt;&lt;ref name=&quot;:2&quot; /&gt;&lt;ref name=&quot;:3&quot; /&gt;&lt;ref name=&quot;:5&quot; /&gt; Because feline hyperesthesia syndrome affects the endocrine, nervous, neuromuscular and exocrine systems, other disorders that affect these [[organ system]]s need to be ruled out. This includes skin disorders that cause [[Itch|pruritus]] such as [[Allergy|allergies]], [[Mycosis|fungal infections]], [[Parasitism|parasites]] and [[dermatitis]]; spinal problems such as [[arthritis]], [[Radiculopathy|pinched nerves]] and [[Spinal disc herniation|slipped discs]]; and [[forebrain]] issues that may lead to [[phantom pain]]s.&lt;ref name=&quot;:0&quot; /&gt;&lt;ref name=&quot;:2&quot; /&gt;&lt;ref name=&quot;:3&quot; /&gt; Tests that can be used to eliminate these possibilities include a [[Physical examination|general physical]], [[Neurological examination|neurological exam]], [[Blood test|blood chemistry analysis]], [[Clinical urine tests|urine analysis]], [[radiography]], [[magnetic resonance imaging]], [[muscle biopsy]], bile acid tolerance, [[Cerebrospinal fluid|cerebral spinal fluid analysis]], and [[Serology|serologic testing]] for infectious causes.&lt;ref name=&quot;:0&quot; /&gt;&lt;ref name=&quot;:3&quot; /&gt;

Behavioural history can be a useful diagnostic tool for this syndrome. Information on a cat's tendency towards obsessive compulsive disorders, anxiety, fear, and over-attachment to its owner is highly advantageous for diagnosis and treatment. Wherever possible, cases of feline hyperesthesia syndrome should be referred to a specialist in feline behaviour for a secondary opinion.&lt;ref name=&quot;:1&quot; /&gt;

Although the syndrome is highly misunderstood and there is still much that needs to be learned, it is possible to use current knowledge to guide diagnosis. For instance, while the syndrome may affect domestic cats of any breed, age, or sex, it is possible to use trends to determine the likelihood that a cat with similar clinical signs as those caused by feline hyperesthesia syndrome is indeed experiencing the aforementioned condition.&lt;ref name=&quot;:0&quot; /&gt;&lt;ref name=&quot;:1&quot; /&gt;&lt;ref name=&quot;:2&quot; /&gt;&lt;ref name=&quot;:3&quot; /&gt;&lt;ref name=&quot;:4&quot; /&gt; It is much less likely that a cat that is under a year old and has not reached maturity has the syndrome rather than an alternate ailment that may be causing similar clinical signs.&lt;ref name=&quot;:0&quot; /&gt;&lt;ref name=&quot;:1&quot; /&gt;&lt;ref name=&quot;:3&quot; /&gt; Likewise, if a cat belongs to either the Abyssinian, Burmese, Himalayan or Siamese breeds, then feline hyperesthesia syndrome should be considered a lot more carefully as a cause of any possible clinical signs.&lt;ref name=&quot;:0&quot; /&gt;&lt;ref name=&quot;:2&quot; /&gt;&lt;ref name=&quot;:3&quot; /&gt;&lt;ref name=&quot;:8&quot; /&gt;

==Treatment==
The complexity of feline hyperesthesia syndrome is mirrored in its treatment. Treatment options often involve a significant [[Trial and error|trial-and-error]] phase to figure out what will work for the individual affected cat.&lt;ref name=&quot;:2&quot; /&gt; This relates back to the dispute on the cause of the syndrome, as depending on the veterinarian's personal scientific beliefs and the clinical signs present, the veterinarian may recommend different treatment methods.&lt;ref name=&quot;:3&quot; /&gt;

Generally, the first step to treating the syndrome is to eliminate or reduce environmental factors that may cause outbreaks, stress, or anxiety. This is usually done by identifying behaviour that precipitates attacks and limiting factors that lead to this behaviour.&lt;ref name=&quot;:3&quot; /&gt; Most cases require owners to either stop or limit touching the cat's lower-back, maintain scheduled feeding times, and organise specific play times.&lt;ref name=&quot;:0&quot; /&gt;

If behavioural modification does not lessen signs of the syndrome, then [[Pharmacology|pharmacological]] solutions may become necessary.&lt;ref name=&quot;:0&quot; /&gt;&lt;ref name=&quot;:1&quot; /&gt;&lt;ref name=&quot;:3&quot; /&gt; The type of drug used will depend on the suspected underlying cause.&lt;ref name=&quot;:3&quot; /&gt; Listed below are several types of drugs that may be used to treat the condition or its symptoms, common drugs used in the treatment of this condition have been included as examples of each type of drug:

[[Anti-inflammatory|Anti-inflammatory drugs]], such as [[prednisolone]], will be used if it is suspected the cause is related to dermatitis or other skin conditions.&lt;ref name=&quot;:0&quot; /&gt;&lt;ref name=&quot;:1&quot; /&gt;&lt;ref name=&quot;:3&quot; /&gt;

[[Anticonvulsant|Antiepileptic drugs]] will be used if the cause is suspected to be seizure related. [[Phenobarbital]] is the most effective of these drugs but does not work on every cat. [[Gabapentin]] may be used for both its [[analgesic]] and antiepileptic properties. It must, however, be [[xylitol]] free, as xylitol is toxic substance for several animals.&lt;ref name=&quot;:0&quot; /&gt;&lt;ref name=&quot;:1&quot; /&gt;&lt;ref name=&quot;:2&quot; /&gt;&lt;ref name=&quot;:3&quot; /&gt;

Behaviour modifying drugs are used when a behavioural disorder is the suspected cause. These may include [[selective serotonin reuptake inhibitor]]s, [[tricyclic antidepressant]]s, or [[benzodiazepine]]s.&lt;ref name=&quot;:0&quot; /&gt;&lt;ref name=&quot;:1&quot; /&gt;&lt;ref name=&quot;:3&quot; /&gt;&lt;ref name=&quot;Pinney&quot; /&gt;&lt;ref&gt;{{cite book |last=Rand|first=Jacquie | name-list-style = vanc |title=Problem-based feline medicine|url=https://books.google.com/books?id=DtIIjFfCHSIC&amp;pg=PA1016|pages=1016|year=2006|publisher=Elsevier Health Sciences|isbn=0-7020-2488-0}}&lt;/ref&gt;

[[Carnitine]] and [[Cofactor (biochemistry)|coenzymes]] are used when it is suspected that [[myopathy]] is the cause of the attacks.&lt;ref name=&quot;:1&quot; /&gt;&lt;ref name=&quot;:3&quot; /&gt;

Other treatments have also been attempted such as [[acupuncture]] or the use of [[Elizabethan collar]]s and tail bandaging.&lt;ref name=&quot;:3&quot; /&gt;&lt;ref name=&quot;:5&quot; /&gt; Acupuncture has been successfully used as treatment within at least one suspected case of feline hyperesthesia syndrome.&lt;ref name=&quot;:5&quot; /&gt; In extreme cases, the Elizabethan collar and tail bandaging become necessary to stop self-mutilation. Where a successful treatment is found, the treatment must generally be continued for the life of the cat, with clinical signs often reappearing when treatments are discontinued.&lt;ref name=&quot;:3&quot; /&gt;

== References ==
{{reflist}}

== External links ==
* [http://www.vin.com/VINDBPub/SearchPB/Proceedings/PR05000/PR00026.htm World Small Animal Veterinary Association] – World Congress, Vancouver 2001.
* [http://www.petplace.com/cats/feline-hyperesthesia/page1.aspx Dr. Jon]

{{Domestic cat}}{{Skin and subcutaneous tissue symptoms and signs}}{{Veterinary medicine}}

[[Category:Syndromes in cats]]