Title: Hypothyroidism in dogs

{{about|the disease in animals|the disease in humans|Hypothyroidism}}
{{Infobox medical condition
 |name            = Hypothyroidism
 |synonyms        =  &lt;!-- or |synonym= --&gt;
 |image           = File:Hypothyroid Labrador retriever 1.jpg
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 |caption         = [[Labrador Retriever]] with hypothyroidism
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 |pronounce       = 
 |pronounce 2     = 
 |specialty       = Endocrinology
 |symptoms        = Lethargy, endocrine [[alopecia]], Obesity
 |complications   = Infections, [[Bradycardia]]
 |onset           = Usually older dogs for most forms, at birth for congenital hypothyroidism
 |duration        = Lifelong if not treated
 |types           = Congenital, Primary, Secondary, Tertiary
 |causes          = Inadequate levels of thyroid-hormone
 |risks           = Certain breeds
 |diagnosis       = Testing for thyroid hormone levels, Imaging of thyroid
 |differential    = Hypersomatotropism
 |prevention      = 
 |treatment       = Levothyroxine
 |medication      = 
 |prognosis       = Depends on condition and state of thyroid gland; very poor for congenital and myxoedema coma.
 |frequency       = 0.23%&lt;ref&gt;{{cite journal | last1=O’Neill | first1=Dan G. | last2=Khoo | first2=Janine Su Pheng | last3=Brodbelt | first3=Dave C. | last4=Church | first4=David B. | last5=Pegram | first5=Camilla | last6=Geddes | first6=Rebecca F. | title=Frequency, breed predispositions and other demographic risk factors for diagnosis of hypothyroidism in dogs under primary veterinary care in the UK | journal=Canine Medicine and Genetics | publisher=Springer Science and Business Media LLC | volume=9 | issue=1 | date=2022-10-10 | issn=2662-9380 | doi=10.1186/s40575-022-00123-8 | doi-access=free | article-number=11 | pmc=9552398 }}&lt;/ref&gt;
 |deaths          = 
 |named after     = &lt;!-- or |eponym= --&gt;
}}
'''Hypothyroidism''' is an [[endocrine disorder]] in which the [[thyroid gland]] fails to produce sufficient [[thyroid hormone]]s. Hypothyroidism is one of the most common [[endocrinopathies]] in dogs. It is either acquired or [[congenital]].&lt;ref name=&quot;endo&quot;&gt;{{cite book |author1-first=J. Catherine |author1-last=Scott-Moncrieff |editor1-last=Feldman | editor1-first=Edward C. | editor2-last=Nelson | editor2-first=Richard W. | editor3-last=Reusch | editor3-first=Claudia | editor4-last=Scott-Moncrieff | editor4-first=J. Catharine |title=Canine and feline endocrinology |date=2015 |publisher=Elsevier Saunders |location=St. Louis, Missouri |isbn=978-1-4557-4456-5 |edition=Fourth |url=http://www.sciencedirect.com/book/9781455744565/canine-and-feline-endocrinology |chapter=Hypothyroidism| publication-place=St. Louis, Missouri | pages=77–128}}&lt;/ref&gt;{{TOC limit|3}}

==Classification==
Hypothyroidism is classified as either primary, secondary, or tertiary. Primary hypothyroidism is for when the cause is due to an abnormality of the thyroid gland, secondary hypothyroidism is when the cause is decreased [[thyroid-stimulating hormone]] levels, and tertiary hypothyroidism is when the cause is an inadequate amount of [[thyrotropin-releasing hormone]] being released.&lt;ref name=&quot;endo&quot;/&gt;

==Causes==
The causes of primary hypothyroidism include:&lt;ref name=&quot;endo&quot;/&gt;
*[[Lymphocytic]] [[thyroiditis]]
*[[Idiopathic]] [[atrophy]]
*[[Neoplasia]] destroying the thyroid gland
*[[Iodine deficiency]]
*Ingestion of [[goitrogen]]
*[[Iatrogenic]]
*[[Leishmaniasis]]
*[[Congenital]] hypothyroidism
Lymphocytic thyroiditis and idiopathic atrophy are the most common causes of primary hypothyroidism.&lt;ref name=&quot;endo&quot;/&gt;

The causes of secondary hypothyroidism include:&lt;ref name=&quot;endo&quot;/&gt;
*Pituitary [[malformation]]
*Pituitary [[cyst]]
*Neoplasia destroying the pituitary gland
*Defective thyroid-stimulating hormone molecules
*Defective thyroid-stimulating hormone-follicular cell receptors
*Iatrogenic

The causes of tertiary hypothyroidism include:&lt;ref name=&quot;endo&quot;/&gt;
*Congenital [[hypothalamic]] malformation
*Acquired hypothalamic destruction
*Defective [[thyrotropin-releasing hormone]] molecules
*Defective thyrotropin-releasing hormone-thyrotroph receptors

===Primary hypothyroidism===
====Lymphocytic thyroiditis====
Lymphocytic thyroiditis is caused by an immune-mediated response to the thyroid gland. The exact mechanism is not known and the understanding of it is poor; however, it is believed that antibodies binding to the follicular cells, colloid, or thyroglobulin antigens activates the process that causes follicular destruction. Breed is an important factor given the increased incidence in certain breeds, such as the [[Beagle]].&lt;ref name=&quot;endo&quot;/&gt;

====Neoplastic destruction====
After a tumour—either one originating in the thyroid gland or invading it—has destroyed 80% or more of the thyroid gland, symptoms of hypothyroidism may occur. Only approximately 10% of thyroid tumours cause hypothyroidism, this in part due to most thyroid tumours not affecting the whole thyroid gland.&lt;ref name=&quot;endo&quot;/&gt;

====Idiopathic atrophy====
Idiopathic atrophy is the [[Degeneration (medicine)|gradual reduction]] in the size of thyroid follicles and replacement of these follicles with adipose tissue. It may be the end stage of lymphocytic thyroiditis or a primary degenerative disorder.&lt;ref name=&quot;endo&quot;/&gt;

====Iodine deficiency====
[[Iodine deficiency]] is a rare cause of hypothyroidism for dogs: commercial [[dog food]]s typically contain sufficient levels of iodine for dogs. In recent years there has been an interest in homemade diets for pets, these diets are not always providing sufficient levels of iodine. [[Working dog]]s fed all meat diets have been reported to suffer from hypothyroidism due to iodine deficiency. In addition to iodine deficiency, excessive amounts of iodine can cause thyroid impairment and lead to hypothyroidism.&lt;ref name=&quot;endo&quot;/&gt;

====Other causes====
[[Goitrogen]]s and [[anti-thyroid medication]] is a potential cause of primary hypothyroidism, but is rare in practice.&lt;ref name=&quot;endo&quot;/&gt;

[[Thyroidectomy]] may cause hypothyroidism: in one study more than 50% of dogs that underwent a bilateral thyroidectomy required long term thyroid hormone treatment.&lt;ref&gt;{{cite journal | last1=Tuohy | first1=Joanne L. | last2=Worley | first2=Deanna R. | last3=Withrow | first3=Stephen J. | title=Outcome following simultaneous bilateral thyroid lobectomy for treatment of thyroid gland carcinoma in dogs: 15 cases (1994–2010) | journal=Journal of the American Veterinary Medical Association | volume=241 | issue=1 | date=2012-07-01 | issn=0003-1488 | doi=10.2460/javma.241.1.95 | pages=95–103}}&lt;/ref&gt;&lt;ref name=&quot;endo&quot;/&gt;

[[Radioactive iodine]] used to treat thyroid neoplasia can also result in hypothyroidism.&lt;ref name=&quot;endo&quot;/&gt;

===Secondary hypothyroidism===
Secondary hypothyroidism occurs when pituitary [[thyrotrophs]] fail to develop, resulting in impaired thyroid-stimulating hormone secretion. Inadequate levels of thyroid-stimulating hormone causes a decrease in thyroid hormone synthesis and secretion and cause [[hypoplasia]] of the thyroid gland.&lt;ref name=&quot;endo&quot;/&gt;

Secondary hypothyroidism caused by naturally acquired defects of thyrotrophs, like those resulting from a neoplasia, are uncommon. Secondary hypothyroidism caused by thyrotroph suppression from a comorbidity, malnutrition, hormones or drugs is a very common cause of secondary hypothyroidism.&lt;ref name=&quot;endo&quot;/&gt;

====Pituitary destruction====
The destruction of thyrotrophs by a pituitary neoplasia may cause secondary hypothyroidism, although pituitary neoplasias do not commonly cause secondary hypothyroidism.&lt;ref name=&quot;endo&quot;/&gt;

===Tertiary hypothyroidism===
Tertiary hypothyroidism is caused by an inadequate amount of thyrotropin-releasing hormone being secreted by the [[hypothalamus]]. Thyrotropin-releasing hormone stimulates release of thyroid-stimulating hormones, thus a lack of thyrotropin-releasing hormone causes a decrease in thyroid-stimulating hormone which causes follicular atrophy.&lt;ref name=&quot;endo&quot;/&gt;

===Congenital hypothyroidism===
Congenital hypothyroidism is a rare and is often underdiagnosed due to dogs with the condition often dying as young puppies. Congenital hypothyroidism is caused by a defect in the [[hypothalamic–pituitary–thyroid axis]] or the thyroid hormone receptor. It is not uncommon for puppies with the condition to die early due to retarded growth and dwarfism. Signs of congenital hypothyroidism typically shown within the first 3 months.&lt;ref name=&quot;endo&quot;/&gt;

==Signs and symptoms==
Signs of hypothyroidism vary based on factors such as the type and breed. Due to the slow onset and progress of the disease clinical signs do not initially appear for example, clinical signs do not show until the 3rd stage of lymphocytic thyroiditis. It is not uncommon for owners to ignore certain signs of hypothyroidism due to the slow progression of metabolic symptoms. Often metabolic symptoms will go unnoticed until after a dog has received treatment for hypothyroidism.&lt;ref name=&quot;endo&quot;/&gt;

The most common signs of hypothyroidism are dermatological and changes relating to the  decreased [[metabolism]].&lt;ref name=&quot;endo&quot;/&gt; In one study the most common symptoms were dermatological conditions, [[Obesity in dogs|obesity]], and [[lethargy]]. Nearly 9/10 dogs had dermatological symptoms, lethargy and obesity were observed in almost half of all dogs.&lt;ref&gt;{{cite journal | last=DL | first=Panciera | title=Conditions associated with canine hypothyroidism | journal=The Veterinary Clinics of North America. Small Animal Practice | date=2001 | publisher=Vet Clin North Am Small Anim Pract | volume=31 | issue=5 | pages=935–950 | doi=10.1016/S0195-5616(01)50006-6 | issn=0195-5616 | pmid=11570133 }}&lt;/ref&gt;

The lowered concentration of thyroid hormone has an effect on organs throughout the body.&lt;ref name=&quot;Esp&quot;&gt;{{cite journal | last1=Diaz-Espiñeira | first1=M.M. | last2=Galac | first2=S. | last3=Mol | first3=J.A. | last4=Rijnberk | first4=A. | last5=Kooistra | first5=H.S. | title=Thyrotropin-releasing hormone-induced growth hormone secretion in dogs with primary hypothyroidism | journal=Domestic Animal Endocrinology | volume=34 | issue=2 | date=2008 | doi=10.1016/j.domaniend.2007.02.001 | pages=176–181}}&lt;/ref&gt;

=== Dermatological ===
The decrease in thyroid hormone levels causes dermatological conditions, specifically [[alopecia]], which is the most common dermatological symptom, as the hair sheds but cannot regrow fast enough due to the [[anagen]] stage of hair growth being stunted as thyroid hormone is important in that stage of hair growth. Other dermatological symptoms include: [[hyperkeratosis]], [[hyperpigmentation]], [[seborrhoea]], [[pyoderma]], [[otitis externa]], and [[myxoedema]]. Breed variation in [[Dog coat|coats]] can impact the dermatological effect of hypothyroidism. Some dogs develop [[hypertrichosis]] and some develop either a wool-like or a coarse appearance. Immune dysregulation, caused by hypothyroidism, can lead to superficial bacterial infection.&lt;ref name=&quot;endo&quot;/&gt;

Myxoedema, also known as cutaneous mucinosis, occurs when [[hyaluronic acid]] builds up in the [[dermis]], this build up may cause swelling and thickening of the skin. Myxoedema is a feature of severe cases of hypothyroidism and is sometimes used synonymously. The characteristic facial expression of hypothyroidism is in part caused by myxoedema.&lt;ref name=&quot;endo&quot;/&gt;

=== Neurological ===
Hypothyroidism can affect the [[Peripheral nervous system|peripheral]] and [[central nervous system]]. Neurological symptoms vary widely and it is not currently known what is responsible for causing neurological symptoms, although multiple theories have been put forward. Some of the other proposed causes of neurological symptoms include: [[nerve entrapment]], due to mucinous deposits; [[demyelination]], due to disruptions to the metabolism of [[Schwann cells]]; vascular [[nerve damage]], due to changes to the blood-nerve barrier; and disruption of the [[axonal cell]] transport. An immune-related cause has been put forward as well, due to the presence of immune-mediated thyroiditis in some dogs with hypothyroidism.&lt;ref name=&quot;endo&quot;/&gt;

=== Reproductive ===
There is a belief of an association between hypothyroidism and reproductive symptoms causing poor reproductive ability. Studies have not identified this association; however, there is no definitive evidence from studies that can rule out an association. It is recommended that when common causes of poor reproductive ability have been ruled out that hypothyroidism be considered as a possible cause. Hypothyroidism can result in excessive [[prolactin]] secretion due to increased thyrotropin-releasing hormone levels. Excessive prolaction secretion causes [[hyperprolactinaemia]] and may cause improper [[lactation]] in unspayed bitches.&lt;ref name=&quot;endo&quot;/&gt;

=== Cardiovascular ===
It is uncommon for cardiovascular symptoms to be diagnosed during a clinical exam. The cardiovascular symptoms that are most often diagnosed during examination are [[bradycardia]] and a deficit of the [[apical impulse]]. The exact mechanism behind the cause of cardiovascular and [[haemodynamic]] symptoms is unknown but may be due to the effects of hypothyroidism on the [[cardiac muscle]].  Most cardiac abnormalities in dogs with hypothyroidism are typically mild and thus is not a cause for concern outside of long surgical procedures. [[Heart failure]] may occur in cases of primary hypothyroidism; however, heart failure caused by hypothyroidism is rare, most cases of heart failure are a preexisting condition being exacerbated by the thyroid hormone deficiency. Thyroid hormone treatment usually results in a cessation of cardiac abnormalities, although it may take several months for this to occur.&lt;ref name=&quot;endo&quot;/&gt;

=== Myxoedema coma ===
[[Myxoedema]] coma is a very rare but deadly form of severe hypothyroidism characterised by myxoedema, [[asthaenia]], [[hypothermia]], [[bradycardia]] and [[organ dysfunction]], [[hypotension]], [[hypoventilation]] and unresponsiveness. It may swiftly progress to [[stupor]] and [[coma]]. Dogs with the condition have similar test results as those with normal hypothyroidism but prognosis is very poor and most dogs will die from organ failure or an infection occurring alongside the condition. The condition often occurs after a bacterial infection or a bout of hypothermia.&lt;ref name=&quot;endo&quot;/&gt;

=== Endocrine ===
Due to the effect thyroid hormone has on the pituitary gland hypothyroidism can cause hypersecretion of growth hormone.&lt;ref&gt;{{cite journal | last1=Diaz-Espiñeira | first1=M.M. | last2=Mol | first2=J.A. | last3=van den Ingh | first3=T.S.G.A.M. | last4=van der Vlugt-Meijer | first4=R.H. | last5=Rijnberk | first5=A. | last6=Kooistra | first6=H.S. | title=Functional and morphological changes in the adenohypophysis of dogs with induced primary hypothyroidism: Loss of TSH hypersecretion, hypersomatotropism, hypoprolactinemia, and pituitary enlargement with transdifferentiation | journal=Domestic Animal Endocrinology | volume=35 | issue=1 | date=2008 | doi=10.1016/j.domaniend.2008.03.001 | pages=98–111}}&lt;/ref&gt;

===Risk factors===
Hypothyroidism symptoms are usually diagnosed in older dogs, this may be in part due to the slow onset of symptoms.&lt;ref name=&quot;endo&quot;/&gt;

Breed is a factor in the progression and likelihood of thyroiditis. [[Golden Retriever]]s and [[Doberman Pinscher]]s are often reported as having a predilection for the condition. Breeds with a described mutation in the [[Thyroid peroxidase|TPO]] gene include: [[Toy Fox Terrier]]s, [[Rat Terrier]]s, [[Tenterfield Terrier]]s, and [[Spanish Water Dog]]s. Environmental factors have not been well described in the literature.&lt;ref name=&quot;endo&quot;/&gt;

In a study of more than 140,000 serum samples of suspected hypothyroidism, the five breeds with the highest prevalence of thyroglobulin autoantibodies were: [[English Setter]] (31%), [[Old English Sheepdog]] (23%), [[Boxer dog|Boxer]] (19%), [[Giant Schnauzer]] (19%), and [[American Pit Bull Terrier]] (19%).&lt;ref&gt;{{cite journal | last1=Graham | first1=Peter A. | last2=Refsal | first2=Kent R. | last3=Nachreiner | first3=Raymond F. | title=Etiopathologic Findings of Canine Hypothyroidism | journal=Veterinary Clinics of North America: Small Animal Practice | volume=37 | issue=4 | date=2007 | doi=10.1016/j.cvsm.2007.05.002 | pages=617–631 | pmid=17619002 | url= }}&lt;/ref&gt;

No evidence exists of a predilection for any sex nor whether the animal is [[neutered]] or not.&lt;ref name=&quot;endo&quot;/&gt;

===Congenital hypothyroidism===
Congenital hypothyroidism has unique symptoms that distinguish it from other forms of hypothyroidism such as: dwarfism, growth retardation, [[kyphosis]], retarded [[tooth eruption]], shortened lower jaw, and an enlarged skull. The cause of the symptoms are due to the role of thyroid hormone in bone and mental growth.&lt;ref name=&quot;endo&quot;/&gt;

===Thyrotoxicosis===
[[Thyrotoxicosis]] is when an abnormally high amount of circulating thyroid-hormone is present, in this instance it does not refer to hyperthyroidism but instead excessive levels due to administration of thyroid-hormone treatment. Thyrotoxicosis is a rare side effect in dogs receiving levothyroxine treatment due to the half-life and poor absorption. Thyrotoxicosis occurs when a dog is either given too much levothyroxine or has issues with metabolising it. Symptoms include: [[polypynoea]], anxiety, [[tachycardia]], aggression, polyuria, polydipsia, polyphagia, and [[cachexia]].&lt;ref name=&quot;endo&quot;/&gt;

===Comorbidities===
Immune-mediated endocrine disorders such as [[Diabetes in dogs|diabetes mellitus]] and [[Hypoadrenocorticism in dogs|hypoadrenocoriticism]] often occur alongside lymphocytic thyroiditis. One study found 4% of dogs with hypoadrenocorticism also had hypothyroidism and one dog had hypoadrenocorticism, hypothyroidism, diabetes mellitus, and [[hyperparathyroidism]]. [[Orchitis]] occurring alongside thyroiditis has been documented in Beagles. The average time for a diagnosis of a second endocrinopathy is 4 months, with one dog having a period of 53 months between diagnosis.&lt;ref name=&quot;endo&quot;/&gt;

A pituitary tumour that causes pituitary destruction may cause hypothyroidism, alongside: [[hypocortisolism]], [[diabetes insipidus]], and [[sexual dysfunction]].&lt;ref name=&quot;endo&quot;/&gt;

==Pathophysiology==
===Lymphocytic thyroiditis===
Lymphocytic thyroiditis is the [[infiltration (medicine)|infiltration]] of the thyroid gland by lymphocytes, [[plasma cells]], and [[macrophages]]. The infiltration progressively causes destruction of follicles and [[secondary fibrosis]]. Clinical signs typically do not show before 80% of the thyroid gland has been destroyed. This destruction occurs over a long period of time, between 1–3 years. This destruction is classified into four stages: ''[[subclinical]] thyroiditis'', when the infiltration of thyroid follicles occurs, test results will be positive for [[thyroglobulin]] and thyroid hormone autoantibodies; ''antibody positive subclinical hypothyroidism'', when the loss of more than 60% of thyroid gland mass has occurred and in response there is an increase of thyroid-stimulating hormone, this stimulates the thyroid gland to maintain [[thyroxine]] levels; ''antibody positive overt hypothyroidism'', when a majority of the functional thyroid tissue has been destroyed, test results will show a decrease in serum thyroid hormone concentration and an increase in thyroid-stimulating hormone concentration; and ''noninflammatory atrophic hypothyroidism'', when the thyroid tissue has been replaced by [[fibrous]] and [[adipose]] tissue and a disappearance of inflammatory cells and circulating antibodies has occurred.&lt;ref name=&quot;endo&quot;/&gt;

==Diagnosis==
Given the possible comorbidities and other causes of low serum concentrations of thyroxine it can be difficult to definitively diagnose hypothyroidism. Strong cause for a diagnosis exists when clinical signs are showing, test results are indicative, and no other illness is present. To exclude the possibility of a thyroid responsive disease thyroid supplementation treatment can be ceased once symptoms have disappeared, if symptoms re-occur after 6–8 weeks this excludes a thyroid responsive disease.&lt;ref name=&quot;endo&quot;/&gt;   
===Lymphocytic thyroiditis===
Lymphocytic thyroiditis can be diagnosed as the cause of hypothyroidism via [[histological]] examination. Histological examination will reveal [[mononuclear]] cell infiltration, the absence of follicles containing colloid, and a change in the normal appearance and layout of the cells. [[Proteinuria]] may be identified in dogs with lymphocytic thyroiditis but otherwise [[urinalysis]] results should be normal.&lt;ref name=&quot;endo&quot;/&gt;

===Idiopathic atrophy===
There are no tests for idiopathic atrophy and due to that it is made via [[diagnosis of exclusion]]. Negative results on tests for other forms and symptoms aligning with the condition are used to diagnose it.&lt;ref name=&quot;endo&quot;/&gt;

===Secondary hypothyroidism===
Secondary hypothyroidism can be histologically diagnosed by looking at the follicles of the thyroid gland, these follicles will by [[hypoplastic]] and lack in colloids in cases of secondary hypothyroidism. Testing will typically reveal decreased or absent levels of thyroid-stimulating hormone; however, this result does not confirm secondary hypothyroidism.&lt;ref name=&quot;endo&quot;/&gt;

===Congenital hypothyroidism===
In dogs with clinical hypothyroidism the symptoms are more pronounced. A [[goitre]] will be present if the [[hypothalamus-pituitary-thyroid axis]] is intact. Serum thyroid-stimulating hormone concentration varies based on aetiology.&lt;ref name=&quot;endo&quot;/&gt;

===Tertiary hypothyroidism===
When tertiary hypothyroidism is suspected it can be confirmed via testing, if thyroid-stimulating hormone levels increase after thytropin-releasing hormones have been administered then a diagnosis of tertiary hypothyroidism has been confirmed. The sensitivity of the thyroid-stimulating hormone assays for dogs makes this is a difficult diagnosis.&lt;ref name=&quot;endo&quot;/&gt;

===Differential diagnosis===
Dogs being treated for [[Epilepsy in animals|epilepsy]] may be incorrectly diagnosed as having hypothyroidism as [[anticonvulsant]] medication used to treat epilepsy can alter the results of tests that measure thyroid hormone levels. Dogs being treated with anticonvulsant medications that lower serum thyroxine levels such as [[phenobarbital]] do not appear to cause any symptoms of hypothyroidism.&lt;ref name=&quot;endo&quot;/&gt;

Euthyroid sick syndrome, also known as nonthyroidal illness syndrome, is a term to describe when a [[euthyroid]] patient has low levels of serum thyroid hormone due to nonthyroidal illness. Causes can be essentially any systemic illness, as well as trauma and insufficient calorie intake. Dermatological conditions are unlikely to affect thyroid function. Multiple mechanisms and conditions cause this condition. Different conditions do not appear to be more likely to cause more severe changes to serum thyroid hormone concentration but instead more severe illness causes more severe changes. Common causes of euthyroid sick syndrome include: neoplasia, renal disease, hepatic disease, neurological disease, cardiac failure, inflammatory disease, and [[diabetic ketoacidosis]].&lt;ref name=&quot;endo&quot;/&gt;

In 40-50% of dogs with [[Cushing's syndrome (veterinary)|Cushing's syndrome]] thyroxine and triiodothyronine levels are decreased. Cushing's is a potential differential diagnosis for hypothyroidism when the patient presents with endocrine alopecia. Clinical history can be used to differentiate the two: [[polyuria]], [[polydipsia]], and [[polyphagia]] are symptoms of Cushing's but not hypothyroidism.  If Cushing's is suspected a urinalysis of the cortisol/creatinine ratio can be used to diagnosis or exclude Cushing's.&lt;ref name=&quot;endo&quot;/&gt;

===Electrocardiography===
Common [[electrocardiographic]] findings in dogs showing symptoms of hypothyroidism include [[sinus bradycardia]] and [[atrioventricular block]]s.&lt;ref name=&quot;endo&quot;/&gt;

===Echocardiography===
Common [[echocardiographic]] findings in dogs showing symptoms of hypothyroidism include an increased systolic diameter of the left ventricle, a decreased thickness of the left posterior ventricular wall, and prolongation of the pre-ejection period when the heart muscle contracts; and changes to the left ventricular posterior wall, interventricular wall thickness, and diameter of the aorta.&lt;ref name=&quot;endo&quot;/&gt;

===Complete blood count===
A form of [[anaemia]] that is [[normocytic]], [[normochromic]], and non-regenerative is diagnosed in approximately 30% of dogs with hypothyroidism.&lt;ref name=&quot;endo&quot;/&gt;

===Serum biochemistry===
The most common finding in with a serum biochemistry panel is fasting [[hypercholesterolaemia]], this finding appears in approximately 75% of dogs with hypothyroidism. [[Hypertriglyceridaemia]] is also a common finding. Neither of these are pathognomonic; however, they are supportive evidence of hypothyroidism. Increases in serum [[lactate dehydrogenase]], [[aspartate aminotransferase]], [[alanine aminotransferase]], and [[alkaline phosphatase]] activity.&lt;ref name=&quot;endo&quot;/&gt;

===Radiography===
[[Radiography]] is not standard procedure for identifying acquired hypothyroidism. Cervical spine radiographs are only useful when [[neoplasia]] is suspected as the cause.&lt;ref name=&quot;endo&quot;/&gt;

Abnormalities can be detected via radiography in cases of congenital hypothyroidism and these include: retarded [[epiphyseal ossification]]; [[epiphyseal dysgenesis]]; [[brachycephalic]] skull, when untypical for the breed or shorter than expected; shortened vertebral body; reduced length of diaphyses of long bones; retarded [[ossification]]; and retarded maturation.&lt;ref name=&quot;endo&quot;/&gt;

===Ultrasound===
An [[ultrasound]] is often used when a thyroid neoplasm is suspected. An ultrasound allows for a real time image of the thyroid gland to be evaluated. An ultrasound is a useful way to diagnose or exclude [[euthyroid sick syndrome]]. In cases of hypothyroidism the thyroid lobes appear round or oval in shape when viewed from the [[transverse plane]], [[hypoechoic]], and a smaller volume and area than clinically healthy patients.&lt;ref name=&quot;endo&quot;/&gt; A study in 2005 found an ability to diagnose hypothyroidism correctly 96% of the time when euthyroid sick syndrome was also suspected as a possible diagnosis.&lt;ref&gt;{{cite journal | last1=Reese | first1=Sven | last2=Breyer | first2=Ulrike | last3=Deeg | first3=Cornelia | last4=Kraft | first4=Wilfried | last5=Kaspers | first5=Bernd | title=Thyroid Sonography as an Effective Tool to Discriminate between Euthyroid Sick and Hypothyroid Dogs | journal=Journal of Veterinary Internal Medicine | volume=19 | issue=4 | date=2005 | issn=0891-6640 | doi=10.1892/0891-6640(2005)19[491:TSAAET]2.0.CO;2 | page=491| doi-access=free }}&lt;/ref&gt;

===Blood testing===
[[Blood testing]] can be used to measure the baseline serum thyroid hormone concentrations, which is in turn used to determine whether an animal has thyroid dysfunction. Measuring thyroid dysfunction via stimulation of the thyroid with thyroid-stimulating hormone is considered the most accurate method of diagnosing hypothyroidism; however, due to the cost of this method it is rarely performed. Other methods involve testing for the levels of [[thyroxine]], [[triiodothyronine]], and thyroid-stimulating hormone. Thyroxine makes up most of the thyroid hormone produced by the thyroid gland. Thyroxine is resilient to common forms of degradation and can survive over a week at room temperature. Certain breeds, including the [[Greyhound]], [[Whippet]], [[Sloughi]], [[Saluki]], [[Basenji]], [[Irish Wolfhound]], and some [[Alaskan sled dog]]s, have levels of thyroid hormone that differ from the norm.

Thyroid hormone levels can fluctuate due to a number of causes such as another illness, especially euthyroid sick syndrome. Levels of thyroxine and triiodothyronine in blood serum are increased in bitches during [[dioestrus]], possibly due to [[progesterone]] improving the binding.&lt;ref name=&quot;endo&quot;/&gt;

===Biopsy===
A [[biopsy]] of the thyroid can be used to confirm a diagnosis of primary hypothyroidism in a patient with symptoms and test results that point towards hypothyroidism, especially with severe cases of lymphocytic thyroiditis and thyroid atrophy. A biopsy will not necessarily be able to inform about the health of the thyroid gland and its function. When symptoms and test results are less conclusive a biopsy is more likely to be unable to give a definitive answer. A large portion of the thyroid needs to be destroyed for thyroid failure is noted, this combined with the factors around surgery itself make it a rare procedure for a diagnosis of hypothyroidism.&lt;ref name=&quot;endo&quot;/&gt;

==Treatment==
The main form of treatment for all forms of hypothyroidism is [[levothyroxine sodium]]. This method allows for normal levels of thyroid hormone in tissue and elsewhere whilst keeping the risk of iatrogenic [[Feline hyperthyroidism|hyperthyroidism]] low. The treatment dose for dogs is 10 times that of humans due to a shorter [[half-life]] of serum thyroxine and poorer gastrointestinal absorption. Many factors such as whether treatment is once daily or twice daily, route of administration, and physiology of the animal all have an effect and patients need to be monitored closely whilst undergoing treatment. It is not recommended to change the formulation for a patient. Serum concentrations of thyroxine and thyroid-stimulating hormone should be measured every 6–8 weeks or earlier if the animal does not respond well to treatment or [[thyrotoxicosis]] occurs. Measurements should be taken 4–6 hours after levothyroxrine treatment in dogs receiving treatment twice per day and 4–6 hours before and after in dogs treated once per day. In severe cases, such as myxoedema coma, when [[hypometabolism]] is occurring the treatment should be administered intravenously.&lt;ref name=&quot;endo&quot;/&gt;

Evaluation of treatment should not occur until at least 6–8 weeks have passed. Symptoms of hypothyroidism should resolve if treatment is effective. Lethargy and torpidity is usually resolved within the first month and obesity by around two months; however, other factors can impact obesity. While symptoms should have resolved after this 6–8 weeks full regrowth of the coat following endocrine alopecia may not occur until several months after starting treatment. Myocardial improvement can occur as early as a month but in some patients it will not occur until around a year has passed.&lt;ref name=&quot;endo&quot;/&gt;

===Liothyronine===
[[Liothyronine]] treatment causes serum triiodothyronine levels to return to normal but thyroxine levels remain low. Liothyronine whilst not the initial choice of treatment may be used when levothyroxine treatment fails and there is reason to believe the cause of failure is gastrointestinal malabsorption.&lt;ref name=&quot;endo&quot;/&gt;

Historically, dogs with normal serum thyroxine levels but low serum levels of triiodothyronine would be treated with liothyronine sodium. A defect in the enzymes responsible for converting thyroxine to triiodothyronine was believed to be responsible; however, no evidence of such a defect occurring has been identified, furthermore if such a defect were to exist it would theoretically be present at birth and result in early death or [[cretinism]].&lt;ref name=&quot;endo&quot;/&gt;

===Myxoedema coma===
Myxoedema coma is often fatal but when identified and treated early prognosis is improved. Contrary to typical treatment where treatment is not started before serum thyroid concentration is measured — given the severity of the condition treatment should be started before waiting for results. Treatment involves treating the underlying hypothyroidism as well as the symptoms such as hypothermia, [[hypovolaemia]], and [[hypoventilation]]. Improvement is typically seen within 24 hours, although death is still common.

===Comorbodities===
====Cardiac disorders====
Thyroid supplementation results in an increased demand for oxygen from the myocardium, an increased heart rate, and potentially a reduction in the [[ventricular filling]] time. Due to this, when a dog is known to have a cardiomyopathy the starting dose should 25%-50% lower.&lt;ref name=&quot;endo&quot;/&gt;

====Hypoadrenocorticism====
In cases of a patient with hypoadrenocorticism and hypothyroidism, treatment of the hypoadrenocorticism should occur before thyroid supplementation due to the potential for levothyroxine sodium treatment to worsen [[electrolyte]] imbalance.&lt;ref name=&quot;endo&quot;/&gt;

====Diabetes mellitus====
Hypothyroidism may cause insulin resistance; treatment for hypothyroidism in a diabetic patient may cause [[hypoglycaemia]], thus diabetic patients need to have their blood glucose monitored.&lt;ref name=&quot;endo&quot;/&gt;

==Prognosis==
A dog with treated primary hypothyroidism should have a life expectancy equivalent to clinically healthy dogs. Prognosis is worse for myxoedema coma and congenital hypothyroidism. Death is still likely following early treatment for myxoedema coma. Prognosis is poor even for treated dogs with congenital hypothyroidism, many of the effects like cretinism and retarded growth result in lifelong complications such as [[osteoarthritis]]. Prognosis for secondary hypothyroidism is poor due to the tumour and pituitary gland destruction.&lt;ref name=&quot;endo&quot;/&gt;

==Epidemiology==
The most common type is acquired primary hypothyroidism which makes up approximately 95% of hypothyroidism cases in dogs. Secondary hypothyroidism is rare and tertiary hypothyroidism is even rarer.&lt;ref name=&quot;endo&quot;/&gt;

==Cats==
The most common thyroid disorder for cats is [[Feline hyperthyroidism|hyperthyroidism]]. Hypothyroidism is a rare condition for cats, the most common causes of low serum concentration of thyroxine in cats is an underlying condition (non-thyroidal illness) or [[iatrogenic]]. Other causes are caused by birth defect. Adult-onset primary/secondary hypothyroidism is very rare.&lt;ref name=&quot;endo&quot;/&gt;

===Iatrogenic===
The most common cause of hypothyroidism in cats is iatrogenic, with most cases occurring following treatment for hyperthyroidism. Multiple treatments for hyperthyroidism can cause hypothyroidism, including: [[thyroidectomy]], [[radiotherapy]] and [[thionamides]].&lt;ref name=&quot;endo&quot;/&gt;

After 2–3 months most cats with iatrogenic hypothyroidism have regained normal thyroid function; however, some cats will need levothyroxine sodium treatment after this.&lt;ref name=&quot;endo&quot;/&gt;

===Adult-onset===
Adult-onset primary hypothyroidism is very rare; in 2014 only 2 cases have been described in detail: one case involved lymphocytic thyroiditis and in the other case the thyroid gland was not identified during necropsy. A cat that suffered head trauma was reported to have developed secondary hypothyroidism. MRI showed the cat to have a small pituitary gland with the [[sella turcica]] being near empty.&lt;ref name=&quot;endo&quot;/&gt;

Common symptoms are lethargy, anorexia, obesity, and dermatological conditions such as alopecia. In addition the torpidity of the cat will cause a decrease in grooming which may lead to matting and poor coat condition.&lt;ref name=&quot;endo&quot;/&gt;

===Congenital===
The most common non-iatrogenic cause of hypothyroidism; congenital hypothyroidism causes dwarfism in cats. Common causes include a resistance to thyroid-stimulating hormone, [[thyroid dyshormonogenesis]], and thyroid [[dysmorphogenesis]]. Other causes have been reported in specific pedigrees or colonies including iodine [[organification]] and [[thyroid peroxidase]] deficiency.&lt;ref name=&quot;endo&quot;/&gt;

Prognosis is guarded and the issues relating to retarded growth are typically lifelong.&lt;ref name=&quot;endo&quot;/&gt;

==References==
{{reflist}}

[[Category:Endocrine diseases]]
[[Category:Dog diseases]]