Title: Musladin-Lueke syndrome

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'''Musladin-Lueke syndrome''' (previously known as Chinese Beagle syndrome) is a [[hereditary disorder]] that affects [[Beagle|beagles]] that manifests in extensive fibrosis of the skin and joints. It is named after beagle breeders Anton Musladin and Ada Leuke. It is caused by a number of [[recessive]] [[Mutation|mutations]] affecting fibrillin-1, a major component of [[Microfibril|microfibrils]].&lt;ref&gt;{{Cite journal|last1=Bader|first1=Hannah L.|last2=Ruhe|first2=Alison L.|last3=Wang|first3=Lauren W.|last4=Wong|first4=Aaron K.|last5=Walsh|first5=Kari F.|last6=Packer|first6=Rebecca A.|last7=Mitelman|first7=Jonathan|last8=Robertson|first8=Kathryn R.|last9=O'Brien|first9=Dennis P.|last10=Broman|first10=Karl W.|last11=Shelton|first11=G. Diane|date=2010-09-17|title=An ADAMTSL2 Founder Mutation Causes Musladin-Lueke Syndrome, a Heritable Disorder of Beagle Dogs, Featuring Stiff Skin and Joint Contractures|journal=PLOS ONE|volume=5|issue=9|article-number=e12817|doi=10.1371/journal.pone.0012817|issn=1932-6203|pmc=2941456|pmid=20862248|bibcode=2010PLoSO...512817B|doi-access=free}}&lt;/ref&gt; It affects several [[Dog anatomy|organ systems]], including the skeleton, heart, skin, and muscle. According to the [[American Kennel Club]]'s Canine Health Foundation, &quot;beagles with Musladin-Leuke syndrome are born with several defects characterized by short outer toes on the front and sometimes all four feet, high set creased ears on a flat skull with extra cartilage in them, slant narrowed eyes, and very thick tight skin with little scruff.&quot; Affected dogs are usually smaller than average, and have a very stiff [[gait]]. Seizures have also been noted in affected dogs.&lt;ref&gt;{{Cite web|title=AKC Canine Health Foundation {{!}} Musladin-Leuke Syndrome|url=https://www.akcchf.org/educational-resources/library/articles/musladin-leuke-syndrome.html|access-date=2021-01-30|website=www.akcchf.org}}&lt;/ref&gt;
== References ==
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[[Category:Genetic dog diseases]]