Title: Multilobular tumour of bone

{{Short description|Tumour of the Canine skull}}
The '''multilobular tumour of bone''' (MTB), also called an osteochondrosarcoma, is the most common tumour of the canine skull,&lt;ref&gt;{{Cite web|title=Bone Tumors - Skull|url=http://www.animalcancersurgeon.com/bone-tumors-skull|access-date=2021-09-13|website=DR. JULIUS LIPTAK|language=en-US}}&lt;/ref&gt; although it is relatively rare in general. 

MTB usually presents as a firm, circumscribed and generally slowgrowing [[Bone tumor|bone tumour]] in older dogs from medium or large breeds. Its biological behaviour may range from benign to malignant, as it has the potential to invade, metastasise and recur.&lt;ref&gt;O'Brien MG, Withrow SJ, Straw RC, Powers BE, Kirpensteijn JK. Total and partial orbitectomy for the treatment of periorbital tumors in 24 dogs and 6 cats: a retrospective study. Vet Surg 1996, 25, 471-479&lt;/ref&gt;&lt;ref&gt;Straw RC, LeCouteur RA, Powers BE, Withrow SJ. Multilobular osteochondrosarcoma of the canine skull: 16 cases (1978-1988). J Am Vet Med Assoc 1989, 195, 1764-1769&lt;/ref&gt; Histologically, it is characterised by the dominant presence of multiple osteoid- or cartilage- containing lobules that are separated by fibrous septae.&lt;ref&gt;Slayter MV, Boosinger TR, Pool RR, Dammrich K, Misdorp W, Larsen S. Histological Classification of Bone and Joint Tumors of [[List of domesticated animals|Domestic Animals]]. pp. 1-50, [[Armed Forces Institute of Pathology]], Washington DC, 1994&lt;/ref&gt;&lt;ref&gt;Thompson KG, Pool RR. Tumors of bones. In: Meuten DJ (ed.). Tumors in Domestic Animals. 4th ed. pp. 296-298, [[Iowa State University]] Press, Ames, 2002&lt;/ref&gt; MTB should be differentiated from other bone tumours.&lt;ref&gt;Loukopoulos P, Thornton JR, Robinson WF. Clinical and pathologic relevance of p53 index in canine osseous tumors. Veterinary Pathology 2003; 40:237-248.&lt;/ref&gt; Although most frequently found in dogs,&lt;ref&gt;Psychas V, Loukopoulos P, Polizopoulou ZS, Sofianidis G. Multilobular tumour of the caudal cranium causing severe cerebral and cerebellar compression in a dog. J Vet Sci 2009; 10:81-83&lt;/ref&gt; MTB has been reported in humans,&lt;ref&gt;Jacobson SA. The Comparative Pathology of the Tumors of Bone. pp. 102-109, Thomas, Springfield, 1971&lt;/ref&gt; cats,&lt;ref&gt;Rossetti E, Bertolini G, Zotti A. Multilobular tumour of bone of the [[Thoracic cavity|thoracic wall]] in a cat. J Feline Med Surg 2007, 9, 254-257&lt;/ref&gt; a horse and a ferret.&lt;ref&gt;Hanley CS, Gieger T, Frank P. What is your diagnosis? Multilobular osteoma (MLO). J Am Vet Med Assoc 2004, 225, 1665-1666&lt;/ref&gt; The [[Medical sign|clinical signs]] depend on the tumour location. Depending on its location and stage in the clinical course, [[Segmental resection|surgical resection]] may result in long-term remission.&lt;ref&gt;Dernell WS, Straw RC, Cooper MF, Powers BE, LaRue SM, Withrow SJ. Multilobular osteochondrosarcoma in 39 dogs: 1979-1993. J Am Anim Hosp Assoc 1998, 34, 11-18&lt;/ref&gt;

==References==
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[[Category:Osseous and chondromatous neoplasia]]
[[Category:Cancer in dogs]]