marginalized transition models for longitudinal binary data with ignorable and non ignorable drop out we extend the marginalized transition model of heagerty to accommodate non ignorable monotone drop out using a selection model weakly identified drop out parameters are held constant and their effects evaluated through sensitivity analysis for data missing at random mar efficiency of inverse probability of censoring weighted generalized estimating equations ipcw gee is as low as 40 per cent compared to a likelihood based marginalized transition model mtm with comparable modelling burden mtm and ipcw gee regression parameters both display misspecification bias for mar and non ignorable missing data and both reduce bias noticeably by improving model fit

sample size considerations for gee analyses of three level cluster randomized trials cluster randomized trials in health care may involve three instead of two levels for instance in trials where different interventions to improve quality of care are compared in such trials the intervention is implemented in health care units clusters and aims at changing the behavior of health care professionals working in this unit subjects while the effects are measured at the patient level evaluations within the generalized estimating equations approach we derive a sample size formula that accounts for two levels of clustering that of subjects within clusters and that of evaluations within subjects the formula reveals that sample size is inflated relative to a design with completely independent evaluations by a multiplicative term that can be expressed as a product of two variance inflation factors one that quantifies the impact of within subject correlation of evaluations on the variance of subject level means and the other that quantifies the impact of the correlation between subject level means on the variance of the cluster means power levels as predicted by the sample size formula agreed well with the simulated power for more than 10 clusters in total when data were analyzed using bias corrected estimating equations for the correlation parameters in combination with the model based covariance estimator or the sandwich estimator with a finite sample correction

on errors in variables for binary regression models summary we consider binary regression models when some of the predictors are measured with error for normal measurement errors structural maximum likelihood estimates are considered we show that if the measurement error is large the usual estimate of the probability of the event in question can be substantially in error especially for high risk groups in the situation of large measurement error we investigate a conditional maximum likelihood estimator and its properties

model for the analysis of binary longitudinal pain data subject to informative dropout through remedication abstract we address the problem of accounting for informative dropout in the form of rescue medication when comparing pain relievers with respect to longitudinal binary pain relief outcomes we present a selection model approach for binary longitudinal data that accommodates informative dropout the relationship between dropout or remedication and the binary pain relief response is assumed to be characterized by a random effect that is conditional on this random effect response and dropout are independent unlike previous approaches to this problem which rely on numerical or approximation methods we obtain a closed form expression for the marginal log likelihood of response and dropout by specifying a complementary log log link function for both components and a conjugate log gamma random effect distribution a data analysis supported by simulation results suggest that the model fits reasonably well results are compared to those obtained from conventional but somewhat inappropriate analyses

scalable programmable quantum gates and a new aspect of the additivity problem for the classical capacity of quantum channels we consider two apparently separated problems in the first part of the article we study the concept of a scalable approximate programmable quantum gate spqg these are special approximate programmable quantum gates with nice properties that could have implications on the theory of universal computation unfortunately as we prove such objects do not exist in the domain of usual quantum theory in the second part the problem of noisy dense coding and generalizations is addressed we observe that the additivity problem for the classical capacity obtained is of apparently greater generality than for the usual quantum channel completely positive maps i e the latter occurs as a special case of the former but as we shall argue with the help of the nonexistence result of the first part the former cannot be reduced to an instance of the latter we conclude by suggesting that the additivity problem for the classical capacity of quantum channels as posed until now may conceptually not be in its appropriate generality

bivariate latent variable models for clustered discrete and continuous outcomes abstract we use the concept of a latent variable to derive the joint distribution of a continuous and a discrete outcome and then extend the model to allow for clustered data the model can be parameterized in a way that allows one to write the joint distribution as a product of a standard random effects model for the continuous variable and a correlated probit model for the discrete variable this factorization suggests a convenient approach to parameter estimation using quasi likelihood techniques our approach is motivated by the analysis of developmental toxicity experiments for which a number of discrete and continuous outcomes are measured on offspring clustered within litters fetal weight and malformation data illustrate the results

variance component models with binary response interviewer variability summary interviewer variability in a binary response is an example of a problem requiring variance component estimation in a non normal family the maximum likelihood estimation procedure is derived and used to examine some binary items on a large questionnaire this raises some interesting questions about the use of unbalanced ano va methods with these data two interviewers asking the same question of the same respondent can obtain different responses such interviewer effects create problems in the design and analysis of survey questionnaires collins 1980 gives a review of these problems together with a variety of partial remedies these include pilot studies and careful design to eliminate difficulties with wording of questions and instructions on the questionnaires in spite of these precautions interviewer effects remain questionnaire items are usually categorical and occasionally binary but usually for analysis the questionnaire item is reduced to a binary response it is the variability of the population of interviewers that is of interest and not just the individual interviewers thus this variability is best modelled as a random effect rather than a fixed effect the number of interviews completed by each interviewer varies so that the design is unbalanced thus we have an unbalanced variance component model with a categorical or binary response the intraclass correlation the ratio of the interviewer variance to the sum of all variances in the model is of great interest as a measure of interviewer variability in estimating the variance components the categorical or binary nature of the response is usually ignored and the analysis carried out using analysis of variance this is not maximum likelihood but analysis of variance does have some desirable properties when the error variables are non normal the rule of thumb generally applied is that the analysis of variance is reasonably accurate as long as the proportions in each of the categories of the response are between 0 1 and 0 9 scheffe 1959 p 343 discusses the effects of non normality in a one way balanced model very little theoretical work has been

mixed effects models with bivariate and univariate association parameters for longitudinal bivariate binary response data summary when two binary responses are measured for each study subject across time it may be of interest to model how the bivariate associations and marginal univariate risks involving the two responses change across time to achieve such a goal marginal models with bivariate log odds ratio and univariate logit components are extended to include random effects for all components specifically separate normal random effects are specified on the log odds ratio scale for bivariate responses and on the logit scale for univariate responses assuming conditional independence given the random effects facilitates the modeling of bivariate associations across time with missing at random incomplete data we fit the model to a dataset for which such structures are feasible a longitudinal randomized trial of a cardiovascular educational program where the responses of interest are change in hypertension and hypercholestemia status the proposed model is compared to a naive bivariate model that assumes independence between time points and univariate mixed effects logit models

practical issues in using generalized estimating equations for inference on transitions in longitudinal data what is being estimated generalized estimating equations gees are commonly used to estimate transition models when the markov assumption does not hold but first order transition probabilities are still of interest the transition inference is sensitive to the choice of working correlation in this paper we consider a random process transition model as the true underlying data generating mechanism which characterizes subject heterogeneity and complex dependence structure of the outcome process in a very flexible way we formally define two types of transition probabilities at the population level naive transition probabilities that average across all the transitions and population average transition probabilities that average the subject specific transition probabilities through asymptotic bias calculations and finite sample simulations we demonstrate that the unstructured working correlation provides unbiased estimators of the population average transition probabilities while the independence working correlation provides unbiased estimators of the naive transition probabilities for population average transition estimation we demonstrate that the sandwich estimator fails for unstructured gee and recommend the use of either jackknife or bootstrap variance estimates the proposed method is motivated by and applied to the next generation health study where the interest is in estimating the population average transition probabilities of alcohol use in adolescents

comparison of statistical methods for analysis of clustered binary observations when correlated observations are obtained in a randomized controlled trial the assumption of independence among observations within cluster likely will not hold because the observations share the same cluster e g clinic physician or subject further the outcome measurements of interest are often binary the objective of this paper is to compare the performance of four statistical methods for analysis of clustered binary observations namely 1 full likelihood method 2 penalized quasi likelihood method 3 generalized estimating equation method 4 fixed effects logistic regression method the first three methods take correlations into account in inferential processes whereas the last method does not type i error rate power bias and standard error are compared across the four statistical methods through computer simulations under varying effect sizes intraclass correlation coefficients number of clusters and number of observations per cluster including large numbers 20 and 100 of observations per cluster the results show that the performance of the full likelihood and the penalized quasi likelihood methods is superior for analysis of clustered binary observations and is not necessarily inferior to that of the fixed effects logistic regression fit even when within cluster correlations are zero

maximum likelihood variance components estimation for binary data abstract we consider a class of probit normal models for binary data and describe ml and reml estimation of variance components for that class as well as best prediction for the realized values of the random effects ml estimates are calculated using an em algorithm for complicated models em includes a gibbs step the computations are illustrated through two examples

modeling conception as an aggregated bernoulli outcome with latent variables via the em algorithm we describe a general method for analyzing aggregated bernoulli outcomes the research is motivated by an epidemiological reproductive study where the outcome was whether pregnancy was detected in a woman s particular menstrual cycle and the bernoulli trials corresponded to days with intercourse during the cycle each cycle is either viable or not i e is or is not susceptible to conception we develop an em algorithm approach to maximizing the observed data pseudo likelihood based on a set of unobservable latent outcomes linked to the specific days with intercourse this method is flexible in that it allows one to model effect of covariates on the susceptibility factor and on the latent outcomes application of the method to fertility studies enables one to investigate covariates with a long term or transient effect on the daily conception probability a complication is that most couples contribute more than one cycle in a prospective study a generalized estimating equation approach adjusts for the dependency among outcomes within individual couples the method can be applied in any setting where dependency among bernoulli trials is induced by a susceptibility factor and the trial outcomes are only observable in the aggregate

testing for treatment related trend with partially exchangeable clustered data when testing for treatment related effect it is common to focus on data that describe some primary response even though an experiment might yield data on secondary less conspicuous effects an example of such an experiment can be found in developmental toxicity studies where a primary response might be the presence of skeletal malformation in a fetus and a secondary effect might be reduced weight in such studies weight reduction may occur not only among malformed fetuses but also among normal fetuses in this paper we use a likelihood ratio procedure to construct treatment related trend tests for developmental experiments with such outcomes we assume that within each cluster data are partially exchangeable and we use the presence or absence of malformations as categorical covariates two models are considered for the covariance structures in the general model partially exchangeable covariance matrices are used for each cluster within dose groups in the homogeneous model a common exchangeable covariance matrix is used for all clusters maximum likelihood estimates mles of unknown parameters in the general model are obtained by directly maximizing the log likelihood function through careful numerical consideration while mles of parameters of teh homogeneous model are obtained through an iterative procedure two applications to developmental toxicity data are described

markov regression models for time series a quasi likelihood approach this paper discusses a quasi likelihood ql approach to regression analysis with time series data we consider a class of markov models referred to by cox 1981 scandinavian journal of statistics 8 93 115 as observation driven models in which the conditional means and variances given the past are explicit functions of past outcomes the class includes autoregressive and markov chain models for continuous and categorical observations as well as models for counts e g poisson and continuous outcomes with constant coefficient of variation e g gamma we focus on poisson and gamma data for illustration analogous to ql for independent observations large sample properties of the regression coefficients depend only on correct specification of the first conditional moment

classifying evolution equations a lie point symmetry classification of evolution equations in 1 1 time space dimensions was presented a combination of the standard lie algorithm for point symmetry and the equivalence group of th

semiparametric regression analysis for recurrent event interval counts this paper deals with analysis of data from longitudinal studies where the rate of a recurrent event characterizing morbidity is the primary criterion for treatment evaluation we consider clinical trials which require patients to visit their clinical center at successive scheduled times as part of follow up at each visit the patient reports the number of events that occurred since the previous visit or an examination reveals the number of accumulated events such as skin cancers the exact occurrence times of the events are unavailable and the actual patient visit times typically vary randomly about the scheduled follow up times each patient s record thus consists of a sequence of clinic visit dates event counts corresponding to the successive time intervals between clinic visits and baseline covariates we propose a semiparametric regression model extending the fully parametric model of thall 1988 biometrics 44 197 209 to estimate and test for covariate effects on the rate of events over time while also accounting for the possibly time varying nature of the underlying event rate covariate effects enter the model parametrically while the underlying time varying event rate is modelled nonparametrically the method of severini and wong 1992 annals of statistics 20 1768 1802 is used to construct asymptotically efficient estimators of the parametric component and to specify their asymptotic distribution a simulation study and application to a data set are provided

matching conditional and marginal shapes in binary random intercept models using a bridge distribution function summary random effects logistic regression models are often used to model clustered binary response data regression parameters in these models have a conditional subject specific interpretation in that they quantify regression effects for each cluster very often the logistic functional shape conditional on the random effects does not carry over to the marginal scale thus parameters in these models usually do not have an explicit marginal population averaged interpretation we study a bridge distribution function for the random effect in the random intercept logistic regression model under this distributional assumption the marginal functional shape is still of logistic form and thus regression parameters have an explicit marginal interpretation the main advantage of this approach is that likelihood inference can be obtained for either marginal or conditional regression inference within a single model framework the generality of the results and some properties of the bridge distribution functions are discussed an example is used for illustration

predicting longitudinal trajectories of health probabilities with random effects multinomial logit regression researchers often encounter longitudinal health data characterized with three or more ordinal or nominal categories random effects multinomial logit models are generally applied to account for potential lack of independence inherent in such clustered data when parameter estimates are used to describe longitudinal processes however random effects both between and within individuals need to be retransformed for correctly predicting outcome probabilities this study attempts to go beyond existing work by developing a retransformation method that derives longitudinal growth trajectories of unbiased health probabilities variances of the predicted probabilities are estimated by using the delta method additionally the covariates regression coefficients on the multinomial logit function not substantively meaningful are transformed to the conditional effects on the predicted probabilities the empirical illustration uses the longitudinal data from the asset and health dynamics among the oldest old ahead our analysis compares three sets of the predicted probabilities of three health states at six time points obtained from respectively the retransformation method the blup and the fixed effects approach the results demonstrate that neglect of retransforming random errors in the random effects multinomial logit model results in severely biased longitudinal trajectories of health probabilities as well as overestimated effects of covariates on the probabilities

random effects models for serial observations with binary response this paper presents a general mixed model for the analysis of serial dichotomous responses provided by a panel of study participants each subject s serial responses are assumed to arise from a logistic model but with regression coefficients that vary between subjects the logistic regression parameters are assumed to be normally distributed in the population inference is based upon maximum likelihood estimation of fixed effects and variance components and empirical bayes estimation of random effects exact solutions are analytically and computationally infeasible but an approximation based on the mode of the posterior distribution of the random parameters is proposed and is implemented by means of the em algorithm this approximate method is compared with a simpler two step method proposed by korn and whittemore using data from a panel study of asthmatics originally described in that paper one advantage of the estimation strategy described here is the ability to use all of the data including that from subjects with insufficient data to permit fitting of a separate logistic regression model as required by the korn and whittemore method however the new method is computationally intensive

sampling bias and logistic models summary in a regression model the joint distribution for each finite sample of units is determined by a function px y depending only on the list of covariate values x x u1 x un on the sampled units no random sampling of units is involved in biological work random sampling is frequently unavoidable in which case the joint distribution p y x depends on the sampling scheme regression models can be used for the study of dependence provided that the conditional distribution p y x for random samples agrees with px y as determined by the regression model for a fixed sample having a non random configuration x the paper develops a model that avoids the concept of a fixed population of units thereby forcing the sampling plan to be incorporated into the sampling distribution for a quota sample having a predetermined covariate configuration x the sampling distribution agrees with the standard logistic regression model with correlated components for most natural sampling plans such as sequential or simple random sampling the conditional distribution p y x is not the same as the regression distribution unless px y has independent components in this sense most natural sampling schemes involving binary random effects models are biased the implications of this formulation for subject specific and population averaged procedures are explored

analytical and numerical solutions of fluid flow filled with and without porous media in circular pipes abstract this paper is connected with obtaining solutions of partial differential equations related with the newtonian and non newtonian fluids flow through pipes filled with porous media by means of one parameter transformation groups which leave the equation invariant solutions of a boundary value problem for a partial differential equation occurring in the research of the flow of newtonian and non newtonian fluids through a porous medium have been confidential the solution of this problem is found by means of the lie group analysis approach the one parameter group transformation reduces the number of independent variables by one and the governing partial differential equation with the boundary conditions reduces to an ordinary differential equation with the appropriate boundary conditions two families of invariant results are acquired also to verify the method and compare the results obtained in the present work against other analytical and numerical solutions available in open literature

the capacity of the quantum channel with general signal states it is shown that the capacity of a classical quantum channel with arbitrary possibly mixed states equals the maximum of the entropy bound with respect to all a priori distributions this completes the recent result of hausladen jozsa schumacher westmoreland and wootters 1996 who proved the equality for the pure state channel

mixed effects logistic regression models for longitudinal binary response data with informative drop out a shared parameter model with logistic link is presented for longitudinal binary response data to accommodate informative drop out the model consists of observed longitudinal and missing response components that share random effects parameters to our knowledge this is the first presentation of such a model for longitudinal binary response data comparisons are made to an approximate conditional logit model in terms of a clinical trial dataset and simulations the naive mixed effects logit model that does not account for informative drop out is also compared the simulation based differences among the models with respect to coverage of confidence intervals bias and mean squared error mse depend on at least two factors whether an effect is a between or within subject effect and the amount of between subject variation as exhibited by variance components of the random effects distributions when the shared parameter model holds the approximate conditional model provides confidence intervals with good coverage for within cluster factors but not for between cluster factors the converse is true for the naive model under a different drop out mechanism when the probability of drop out is dependent only on the current unobserved observation all three models behave similarly by providing between subject confidence intervals with good coverage and comparable mse and bias but poor within subject confidence intervals mse and bias the naive model does more poorly with respect to the within subject effects than do the shared parameter and approximate conditional models the data analysis which entails a comparison of two pain relievers and a placebo with respect to pain relief conforms to the simulation results based on the shared parameter model but not on the simulation based on the outcome driven drop out process this comparison between the data analysis and simulation results may provide evidence that the shared parameter model holds for the pain data

the phase operator in quantum information processing it is shown that unitary depolarizers which play an important role in quantum information processing can be constructed in terms of the pegg barnett phase operator by using the result the classical information capacity of quantum dense coding with unitary encoding in a finite dimensional hilbert space is derived furthermore the relation between the capacity of quantum dense coding and the coherent information of a noisy quantum channel is obtained

a taylor galerkin method for convective transport problems a method is described to derive finite element schemes for the scalar convection equation in one or more space dimensions to produce accurate temporal differencing the method employs forward time taylor series expansions including time derivatives of second and third order which are evaluated from the governing partial differential equation this yields a generalized time discretized equation which is successively discretized in space by means of the standard bubnov galerkin finite element method the technique is illustrated first in one space dimension with linear elements and euler leap frog and crank nicolson time stepping several interesting relations with standard galerkin and recently developed petrov galerkin methods emerge and the new taylor galerkin schemes are found to exhibit particularly high phase accuracy with minimal numerical damping the method is successively extended to deal with variable coefficient problems and multi dimensional situations

analysis of repeated ordered categorical outcomes with possibly missing observations and time dependent covariates abstract this article describes a method for comparing responses in two groups of subjects observed repeatedly at a common set of observation times when the response is an ordered categorical outcome the method which allows both time dependent covariates and missing observations consists of two analytic steps in the first step the data are analyzed separately at each occasion using a regression model chosen from the class of models for ordinal data proposed by mccullagh 1980 the joint asymptotic distribution of the estimates of these occasion specific regression coefficients and a consistent estimator of their asymptotic covariance matrix are obtained without imposing any parametric model of dependence on the repeated observations in the second step this asymptotic distribution together with appropriate simultaneous inference procedures is used to characterize the overall difference between groups and the variation in group differences over time the missing data process may differ between gro

the analysis of ring recovery data using random effects we show how random terms describing both yearly variation and overdispersion can easily be incorporated into models for mark recovery data through the use of bayesian methods for recovery data on lapwings we show that the incorporation of the random terms greatly improves the goodness of fit omitting the random terms can lead to overestimation of the significance of weather on survival and overoptimistic prediction intervals in simulations of future population behavior random effects models provide a natural way of modeling overdispersion which is more satisfactory than the standard classical approach of scaling up all standard errors by a uniform inflation factor we compare models by means of bayesian p values and the deviance information criterion dic

generalization of the mantel haenszel estimating function for sparse clustered binary data we extend the mantel haenszel estimating function to estimate both the intra cluster pairwise correlation and the main effects for sparse clustered binary data we propose both a composite likelihood approach and an estimating function approach for the analysis of such data the proposed estimators are consistent and asymptotically normally distributed simulation results demonstrate that the two approaches are comparable in terms of bias and efficiency however the estimating equation approach is computationally simpler analysis of the georgia high blood pressure survey is used for illustration

quantum dense coding and dynamics of information over bloch channels dynamics of coded information over bloch channels is investigated we show that the coded information is sent with high accuracy over the bloch channel by increasing the absolute equilibrium value of the information carrier or decreasing the ratio of relaxation time the robustness of coded information in maximum and partial entangled states is discussed it is shown that the maximum entangled states are more robust than the partial entangled state over these types of channels the dynamics of the local and the non local information is investigated for different values of the channel s parameters and the initial state setting it is found that by increasing the absolute equilibrium values for both qubits the local information of both qubits decreases faster and consequently the information gained by the eavesdropper increases

mixtures of marginal models summary in this paper we adapt a mixture model originally developed for regression models with independent data for the more general case of correlated outcome data which includes longitudinal data as a special case the estimation is performed by a generalisation of the em algorithm which we call the expectation solution es algorithm in this es algorithm the m step of the em algorithm is replaced by a step requiring the solution of a series of generalised estimating equations the es algorithm a general algorithm for solving generalised estimating equations with incomplete data is then applied to the present problem of mixtures of marginal models in addition to allowing for correlation inherent in correlated outcome data the systematic component of this mixture of marginal models is more flexible than the conventional linear function the methodology is applied in the contexts of normal and poisson response data some theory regarding the es algorithm is presented

projected partial likelihood and its application to longitudinal data summary an estimating equation which we call the projected partial score is introduced for longitudinal data analysis the estimating equation is obtained by projecting the partial likelihood score function onto the vector space spanned by a class of conditionally linear estimating equations we demonstrate that removing certain terms from the projection of the full likelihood score does not alter important inferential properties of the estimating equation and doing so is advantageous in handling missing data and time varying covariates within a prequential frame of reference it is shown that the estimating equation is optimal among the largest collection of estimating equations determined by the conditional moments furthermore the method possesses similar properties to generalised estimating equations in particular the correct conditional variance specification is necessary for efficiency but not for asymptotic consistency and distribution theory

polynomial regression and estimating functions in the presence of multiplicative measurement error we consider the polynomial regression model in the presence of multiplicative measurement error in the predictor two general methods are considered with the methods differing in their assumptions about the distributions of the predictor and the measurement errors consistent parameter estimates and asymptotic standard errors are derived by using estimating equation theory diagnostics are presented for distinguishing additive and multiplicative measurement error data from a nutrition study are analysed by using the methods the results from a simulation study are presented and the performances of the methods are compared

the analysis of binomial data by a generalized linear mixed model summary methods for generalized linear models are extended to provide estimates of location and variance parameters for mixed models fitted to binomial data formed by classifying samples from an underlying normal distribution the method estimates the parameters directly on the underlying scale for a balanced one way random effects model the variance estimator simplifies to the usual analysis of variance one the estimation of variances and the prediction of random effects for binomial traits is required by animal breeders the predictors given are analogous to best linear unbiased predictors henderson 1973 but differ from those presented by harville mee 1984

regression models for nonstationary categorical time series asymptotic estimation theory for the analysis of nonstationary categorical time series a parsimonious and flexible class of models is proposed these models are generalizations of regression models for stochastically independent categorical observations consistency asymptotic normality and efficiency of the maximum likelihood estimator are shown under weak and easily verifiable requirements some models for binary time series are discussed in detail to demonstrate asymptotic properties a theorem is given addressing maximum likelihood estimation for general stochastic processes then it is shown that the assumptions of this theorem are consequences of the requirements for categorical time series for this proof some lemmas are used which may be of interest in similar cases

random effects models for longitudinal data models for the analysis of longitudinal data must recognize the relationship between serial observations on the same unit multivariate models with general covariance structure are often difficult to apply to highly unbalanced data whereas two stage random effects models can be used easily in two stage models the probability distributions for the response vectors of different individuals belong to a single family but some random effects parameters vary across individuals with a distribution specified at the second stage a general family of models is discussed which includes both growth models and repeated measures models as special cases a unified approach to fitting these models based on a combination of empirical bayes and maximum likelihood estimation of model parameters and using the em algorithm is discussed two examples are taken from a current epidemiological study of the health effects of air pollution

tree structured logistic model for over dispersed binomial data with application to modeling developmental effects this article proposes tree structured logistic regression modeling for over dispersed binomial data recursive partitioning is performed using a combination of statistical tests and residual analysis the splitting criterion in cross validation is based on the deviance function a nested grid algorithm to estimate the bootstrap parameters is developed the regression tree procedure provides a new approach for exploring in detail the relationship between the binomial response and explanatory variables the proposed procedure is used to model the relationship between the incidence of malformation and dose and fetal weight using data from a developmental experiment conducted at the national center for toxicological research a conditional gaussian chain model is used to account for the effect of fetal weight by dose

generalized linear models with random effects a gibbs sampling approach abstract generalized linear models have unified the approach to regression for a wide variety of discrete continuous and censored response variables that can be assumed to be independent across experimental units in applications such as longitudinal studies genetic studies of families and survey sampling observations may be obtained in clusters responses from the same cluster cannot be assumed to be independent with linear models correlation has been effectively modeled by assuming there are cluster specific random effects that derive from an underlying mixing distribution extensions of generalized linear models to include random effects has thus far been hampered by the need for numerical integration to evaluate likelihoods in this article we cast the generalized linear random effects model in a bayesian framework and use a monte carlo method the gibbs sampler to overcome the current computational limitations the resulting algorithm is flexible to easily accommodate changes in the number

cluster adjusted regression for displaced subject data cards marginal inference under potentially informative temporal cluster size profiles ignorance of the mechanisms responsible for the availability of information presents an unusual problem for analysts it is often the case that the availability of information is dependent on the outcome in the analysis of cluster data we say that a condition for informative cluster size ics exists when the inference drawn from analysis of hypothetical balanced data varies from that of inference drawn on observed data much work has been done in order to address the analysis of clustered data with informative cluster size examples include inverse probability weighting ipw cluster weighted generalized estimating equations cwgee and doubly weighted generalized estimating equations dwgee when cluster size changes with time i e the data set possess temporally varying cluster sizes tvcs these methods may produce biased inference for the underlying marginal distribution of interest we propose a new marginalization that may be appropriate for addressing clustered longitudinal data with tvcs the principal motivation for our present work is to analyze the periodontal data collected by beck et al 1997 journal of periodontal research 6 497 505 longitudinal periodontal data often exhibits both ics and tvcs as the number of teeth possessed by participants at the onset of study is not constant and teeth as well as individuals may be displaced throughout the study

discretization of partial differential equations preserving their physical symmetries a procedure for obtaining a minimal discretization of a partial differential equation preserving all of its lie point symmetries is presented minimal in this case means that the differential equation is replaced by a partial difference scheme involving n difference equations where n is the number of independent and dependent variables we restrict ourselves to one scalar function of two independent variables as examples invariant discretizations of the heat burgers and korteweg de vries equations are presented some exact solutions of the discrete schemes are obtained

continuous symmetries of lagrangians and exact solutions of discrete equations one of the difficulties encountered when studying physical theories in discrete space time is that of describing the underlying continuous symmetries like lorentz or galilei invariance one of the ways of addressing this difficulty is to consider point transformations acting simultaneously on difference equations and lattices in a previous article we have classified ordinary difference schemes invariant under lie groups of point transformations the present article is devoted to an invariant lagrangian formalism for scalar single variable difference schemes the formalism is used to obtain first integrals and explicit exact solutions of the schemes equations invariant under two and three dimensional groups of lagrangian symmetries are considered

optimal dense coding with mixed state entanglement i investigate dense coding with a general mixed state on the hilbert space cd cd shared between a sender and receiver the following result is proved when the sender prepares the signal states by mutually orthogonal unitary transformations with equal a priori probabilities the capacity of dense coding is maximized it is also proved that the optimal capacity of dense coding satisfies er er log2 d where er is the relative entropy of entanglement of the shared entangled state

analysis of clustered binary outcomes using within cluster paired resampling summary conditional logistic regression clr is useful for analyzing clustered binary outcome data when interest lies in estimating a cluster specific exposure parameter while treating the dependency arising from random cluster effects as a nuisance clr aggregates unmeasured cluster specific factors into a cluster specific baseline risk and is invalid in the presence of unmodeled heterogeneous covariate effects or within cluster dependency we propose an alternative resampling based method for analyzing clustered binary outcome data within cluster paired resampling wcpr which allows for within cluster dependency not solely due to baseline heterogeneity for example dependency may be in part caused by heterogeneity in response to an exposure across clusters due to unmeasured cofactors when both clr and wcpr are valid our simulations suggest that the two methods perform comparably when clr is invalid wcpr continues to have good operating characteristics for illustration we apply both wcpr and clr to a periodontal data set where there is heterogeneity in response to exposure across clusters

comparison of methods for the analysis of longitudinal interval count data longitudinal studies are often concerned with estimating the recurrence rate of a non fatal event in many cases only the total number of events occurring during successive time intervals is known we compared a mixed poisson gamma regression method proposed by thall and a quasi likelihood method proposed by zeger and liang for the analysis of such data in the case where the mean was correctly specified using simulation techniques with large samples both methods produced similar standard errors in most situations except in the case of time dependent covariates with non poisson gamma data where they were seriously underestimated by the thall method a simple method for discriminating between the variance forms of the two methods is described the findings are applied to the analyses of clinical trials of non melanoma skin cancer and familial polyposis this study extends the findings of breslow concerning variance misspecification in overdispersed poisson and quasi likelihood models to the longitudinal setting

operator monotones the reduction criterion and the relative entropy we introduce the theory of operator monotone functions and employ it to derive a new inequality relating the quantum relative entropy and the quantum conditional entropy we present applications of this new inequality and in particular we prove a new lower bound on the relative entropy of entanglement and other properties of entanglement measures

models for longitudinal data a generalized estimating equation approach this article discusses extensions of generalized linear models for the analysis of longitudinal data two approaches are considered subject specific ss models in which heterogeneity in regression parameters is explicitly modelled and population averaged pa models in which the aggregate response for the population is the focus we use a generalized estimating equation approach to fit both classes of models for discrete and continuous outcomes when the subject specific parameters are assumed to follow a gaussian distribution simple relationships between the pa and ss parameters are available the methods are illustrated with an analysis of data on mother s smoking and children s respiratory disease

lie symmetries and exact solutions of first order difference schemes we show that any first order ordinary differential equation with a known lie point symmetry group can be discretized into a difference scheme with the same symmetry group in general the lattices are not regular ones but must be adapted to the symmetries considered the invariant difference schemes can be so chosen that their solutions coincide exactly with those of the original differential equation

a saturated model for analyzing exchangeable binary data applications to clinical and developmental toxicity studies abstract correlated binary data occur very frequently in statistical practice in many applications it is reasonable to assume that data from the same cluster are exchangeable such data are commonly encountered in cluster sample surveys teratological experiments ophthalmologic and otolaryngologic studies and other clinical trials the standard methods of analyzing these data include the use of beta binomial models and generalized estimating equations with third and fourth moments specified by working matrices the focus of these procedures is an estimation of the mean and variance parameters more information can be obtained when data are exchangeable by expressing the joint distribution of a set of exchangeable binary random variables in terms of the probability of similar response within cluster this article introduces a procedure for obtaining maximum likelihood estimates of population parameters such as the marginal means moments and correlations of orders two and higher applications are m

biased estimates of treatment effect in randomized experiments with nonlinear regressions and omitted covariates summary certain important nonlinear regression models lead to biased estimates of treatment effect even in randomized experiments if needed covariates are omitted the asymptotic bias is determined both for estimates based on the method of moments and for maximum likelihood estimates the asymptotic bias from omitting covariates is shown to be zero if the regression of the response variable on treatment and covariates is linear or exponential and in regular cases this is a necessary condition for zero bias many commonly used models do have such exponential regressions thus randomization ensures unbiased treatment estimates in a large number of important nonlinear models for moderately censored exponential survival data analysis with the exponential survival model yields less biased estimates of treatment effect than analysis with the proportional hazards model of cox if needed covariates are omitted simulations confirm that calculations of asymptotic bias are in excellent agreement with the bias observed in experiments of modest size

longitudinal data analysis using generalized linear models summary this paper proposes an extension of generalized linear models to the analysis of longitudinal data we introduce a class of estimating equations that give consistent estimates of the regression parameters and of their variance under mild assumptions about the time dependence the estimating equations are derived without specifying the joint distribution of a subject s observations yet they reduce to the score equations for multivariate gaussian outcomes asymptotic theory is presented for the general class of estimators specific cases in which we assume independence m dependence and exchangeable correlation structures from each subject are discussed efficiency of the proposed estimators in two simple situations is considered the approach is closely related to quasi likelih ood some key ironh estimating equation generalized linear model longitudinal data quasi likelihood repeated measures

marginally specified generalized linear mixed models a robust approach la modelisation des donnees longitudinales est compliquee par la necessite de prendre en compte correctement la correlation entre les observations faites chez le meme individu en partant d une version anterieure non robuste proposee par heagerty 1999 biometrics 55 688 698 notre modele lineaire generalise mixte robuste marginalement robms glmm fournit methode une methode efficace pour traiter de telles donnees ce modele est un des premiers a permettre a la fois des inferences moyennee sur la population et specifique a l individu de plus il adopte la flexibilite et l interpretation des modeles lineaires generalises mixtes pour introduire la dependance mais construit la structure de regression pour l esperance marginale permettant une application valide avec des covariables dependantes du temps exogenes et independantes du temps ces nouveaux estimateurs sont obtenus comme les solutions d une equation de vraisemblance rendue robuste basee sur la distribution la moins favorable de huber et une collection de poids la distribution la moins favorable de huber produit tics estimations qui sont resistantes a certaines deviations des hypotheses de distribution des effets aleatoires des strategies innovantes de ponderation permettent an robs glmm de bien fonctionner quand on est confronte a des observations eloignees a la fois dans la reponse et les covariables nous illustrons la methodologie avec une analyse d une etude longitudinale prospective de l intubation laryngoscopique endotracheale une methode que de nombreux professionnels de sante doivent acquerir le but principal de notre recherche est d obtenir une inference robuste dans les analyses longitudinales