Compound: DADLE
SMILES: O=C(O)[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C)Cc2ccccc2)CC(C)C
InChIKey: ZHUJMSMQIPIPTF-IBURTVSXSA-N
Synonyms: DADLE, 63631-40-3, BW-180C, DADL, [D-Ala2, D-Leu5]-enkephalin, Leucine enkephalin-2-alanine, Enkephalin-leu,ala(2), 2-Alanyl-leucine enkephalin, 5-Leucine-2-alanine enkephalin, CQK2YXW6EZ, (2R)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid, ENKEPHALIN, LEUCINE-2-ALANINE, BW180C, BW 180C, (D-Ala2, D-Leu5)-Enkephalin, D-Leucine, N-(N-(N-(N-L-tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)-, (2R)-2-(((2S)-2-((2-(((2R)-2-(((2S)-2-amino-3-(4-hydroxyphenyl)propanoyl)amino)propanoyl)amino)acetyl)amino)-3-phenylpropanoyl)amino)-4-methylpentanoic acid, Leu Enkephalin 2 Ala, Leu-Enkephalin-2-Ala, RefChem:388951, 2 Alanyl Leucine Enkephalin, Leucine Enkephalin 2 Alanine, Leucine-2-Alanine Enkephalin, Enkephalin, 2-Alanyl-Leucine, Enkephalin, Leucine 2 Alanine, Enkephalin-2-Alanine, Leucine, 5 Leucine 2 Alanine Enkephalin, Enkephalin, 5-Leucine-2-Alanine, D-Ala(2)-D-Leu(5)-Enkephalin, H-TYR-D-ALA-GLY-PHE-D-LEU-OH, (D-Ala2,D-Leu5)-Enkephalin, Tyr-D-Ala-Gly-Phe-D-Leu, [D-Ala2-D-Leu5]enkephalin, CHEMBL340032, ENKEPHALIN-(2-D-ALA, 5-D-LEU), L-Tyrosyl-D-alanylglycyl-L-phenylalanyl-D-leucine, C29H39N5O7, (D-ALA2-D-LEU5)ENKEPHALIN, D-Ala2, D-Leu5-Enkephalin, (D-Ala2,D-Leu5)enkephalin, H-Tyr-D-Ala-Gly-Phe-D-Leu, DADLE-OH, UNII-HB4QD9GL6F, H-Y(dA)GF(dL)-OH, GTPL1607, orb1296450, Tyr-D-Ala-Gly-Phe-D-Leu-OH, SCHEMBL11124725, BDBM21025, CHEBI:234245, D-Ala(2),D-Leu(5)-enkephalin, (2R,5S,11R,14S)-14-Amino-5-benzyl-15-(4-hydroxyphenyl)-2-isobutyl-11-methyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazapentadecan-1-oic acid, [D-Ala(2),D-Leu(5)]enkephalin, [D-Ala(2), D-Leu(5)]enkephalin, MFCD00076411, [D-Ala(2), D-Leu(5)]-enkephalin, AKOS024457800, DB08856, H-Tyr-D-L-Ala-Gly-L-Phe-D-Leu-OH, (2R)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]acetamido}-3-phenylpropanamido]-4-methylpentanoic acid, FA108791, TS-10506, HY-105343, CS-0025794, NS00071158, G77857, Q424905, TYROSYL-D-ALANYLGLYCYLPHENYLALANYL-D-LEUCINE, D-Leucine, L-tyrosyl-D-alanylglycyl-L-phenylalanyl-, (2R)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenyl-propanoyl]amino]-4-methyl-pentanoic acid
Theoretical properties:
molecular_formula: C29H39N5O7
molecular_weight: 569.6 g/mol
exact_mass: 569.28494860 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 7
hydrogen_bond_acceptor_count: 8
rotatable_bond_count: 15
heavy_atom_count: 41
topological_polar_surface_area: 200 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: DADLE is a pentapeptide comprising of L-tyrosine, D-alanine, glycine, L-phenylalanine and D-leucine residues joined in sequence by peptide linkages. It is a synthetic delta-opioid agonist that induces hibernation, promotes survival of neurons and glial cells in the CNS, and exerts neuroprotection. It has a role as an autophagy inducer, a geroprotector, an antinociceptive agent, an opioid analgesic, a mu-opioid receptor agonist, a neuroprotective agent, a delta-opioid receptor agonist and a cardioprotective agent.
chebi: A pentapeptide comprising of <small>L</small>-tyrosine, <small>D</small>-alanine, glycine, <small>L</small>-phenylalanine and <small>D</small>-leucine residues joined in sequence by peptide linkages. It is a synthetic δ-opioid agonist that induces hibernation, promotes survival of neurons and glial cells in the CNS, and exerts neuroprotection.
chembl: DADLE is a protein listed in the ChEMBL database but has not progressed to an approved clinical phase.
wikipedia: DADLE ([D-Ala2, D-Leu5]-Enkephalin) is a synthetic opioid peptide with analgesic properties. Although it is often considered a selective δ-opioid receptor agonist, it also binds to the μ1 subtype of μ-opioid receptors. 
Treatment with DADLE results in transient depression of mean arterial blood pressure and heart rate.
Its peptide sequence is Tyr-D-Ala-Gly-Phe-D-Leu.