Compound: Corynoline
SMILES: O1c2c3c(ccc2OC1)[C@@]4([C@@H](c5c(cc6OCOc6c5)C[C@@H]4O)N(C3)C)C
InChIKey: IQUGPRHKZNCHGC-TYPHKJRUSA-N
Synonyms: Corynoline, 13-methylchelidonine, Chelidonine, 13-methyl-, ZQ9W3JU6N3, DTXSID20940272, (1R,12S,13R)-13,24-dimethyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-2,4(8),9,14(22),15,17(21)-hexaen-12-ol, CHEBI:65660, (1R,12S,13R)-13,24-dimethyl-5,7,18,20-tetraoxa-24-azahexacyclo(11.11.0.02,10.04,8.014,22.017,21)tetracosa-2,4(8),9,14(22),15,17(21)-hexaen-12-ol, RefChem:128172, DTXCID701368743, 18797-79-0, (+)-corynoline, [1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-6-ol, 5b,6,7,12b,13,14-hexahydro-5b,13-dimethyl-, (5bR,6S,12bR)-, (5BR,6S,12BR)-5B,13-DIMETHYL-5B,6,7,12B,13,14-HEXAHYDRO-[1,3]DIOXOLO[4',5':4,5]BENZO[1,2-C][1,3]DIOXOLO[4,5-I]PHENANTHRIDIN-6-OL, 68035-45-0, CHEMBL4126384, (11S,13R,14R)-corynoline, 13,24-Dimethyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-2,4(8),9,14(22),15,17(21)-hexaen-12-ol, (5bR,6S,12bR)-5b,13-dimethyl-5b,6,7,12b,13,14-hexahydro[1,3]benzodioxolo[5,6-c][1,3]dioxolo[4,5-i]phenanthridin-6-ol, Corynoline (Standard), UNII-ZQ9W3JU6N3, orb1300157, orb3140974, SCHEMBL3127828, Corynoline, >=98% (HPLC), SCHEMBL29875106, HY-N0826R, HY-N0826, (invertedexclamationmarkA)-Corynoline, BDBM50276146, MFCD11042250, s9085, AKOS015896713, CCG-268252, EBC-519366, FC73889, ( inverted exclamation markA)-Corynoline, AC-35078, AS-75490, CS-0009858, Q15410919, (1R,12S,13R)-13,24-dimethyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11.0.0^{2,10}.0^{4,8}.0^{14,22}.0^{17,21}]tetracosa-2(10),3,8,14(22),15,17(21)-hexaen-12-ol, (5BR,6S,12BR)-5B,6,7,12B,13,14-HEXAHYDRO-5B,13-DIMETHYL(1,3)BENZODIOXOLO(5,6-C)-1,3-DIOXOLO(4,5-I)PHENANTHRIDIN-6-OL
Theoretical properties:
molecular_formula: C21H21NO5
molecular_weight: 367.4 g/mol
exact_mass: 367.14197277 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 6
rotatable_bond_count: 0
heavy_atom_count: 27
topological_polar_surface_area: 60.4 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Corynoline is a benzophenanthridine alkaloid that is chelidonine substituted by a methyl group at position 13. Isolated from the aerial parts of Corydalis incisa, it acts as an acetylcholinesterase inhibitor and also exhibits antineoplastic and hepatoprotective activity. It has a role as a metabolite, an antineoplastic agent, an EC 3.1.1.7 (acetylcholinesterase) inhibitor and a hepatoprotective agent. It is a member of isoquinolines, a secondary alcohol, a benzophenanthridine alkaloid, an organic heterohexacyclic compound and a cyclic acetal. It is functionally related to a chelidonine.
chebi: A benzophenanthridine alkaloid that is chelidonine substituted by a methyl group at position 13. Isolated from the aerial parts of <em>Corydalis incisa</em>, it acts as an acetylcholinesterase inhibitor and also exhibits antineoplastic and hepatoprotective activity.
chembl: Unnamed Compound is a small molecule listed in the ChEMBL database but has not progressed to an approved clinical phase.
wikipedia: Corynoline is an acetylcholinesterase inhibitor isolated from Corydalis incisa.