Compound: TEPROTIDE
SMILES: O=C1N[C@H](C(=O)N[C@H](C(=O)N2[C@H](C(=O)N[C@H](C(=O)N3[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N4[C@H](C(=O)N5[C@H](C(=O)O)CCC5)CCC4)[C@H](CC)C)CCC(=O)N)CCC3)CCCN=C(N)N)CCC2)Cc6c7c(cccc7)[nH]c6)CC1
InChIKey: UUUHXMGGBIUAPW-CSCXCSGISA-N
Synonyms: TEPROTIDE, 35115-60-7, Tepromide, Teprotidum, SQ-20881, teprotida, SQ 20881, C3E5QBF1R6, DTXSID301029698, SO-20881, Bradykinin potentiator B, 2-L-tryptophan-3-de-L-leucine-4-de-L-proline-8-L-glutamine-, BPP-9a, Bradykinin Potentiating Peptide 9a, Bradykinin-Potentiating Peptide 9a, (2S)-1-((2S)-1-((2S,3S)-2-(((2S)-5-amino-2-(((2S)-1-((2S)-5-guanidino-2-(((2S)-1-((2S)-3-(1H-indol-3-yl)-2-(((2S)-5-oxopyrrolidine-2-carbonyl)amino)propanoyl)pyrrolidine-2-carbonyl)amino)pentanoyl)pyrrolidine-2-carbonyl)amino)-5-oxo-pentanoyl)amino)-3-methyl-pentanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylic acid, (2S)-1-[(2S)-1-[(2S,3S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S)-5-guanidino-2-[[(2S)-1-[(2S)-3-(1H-indol-3-yl)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxo-pentanoyl]amino]-3-methyl-pentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid, Peptide 9a, Bradykinin-Potentiating, Nonapeptide Converting Enzyme Inhibitor, Nonapeptide-Converting Enzyme Inhibitor, Enzyme Inhibitor, Nonapeptide-Converting, RefChem:389305, DTXCID601514903, Angiotensin Converting Enzyme Inhibitor, angiotensin-converting enzyme inhibitor, Teprotide (USAN/INN), 5-Oxo-L-prolyl-L-tryptophyl-L-prolyl-L-arginyl-L-prolyl-L-glutaminyl-L-isoleucyl-L-prolyl-L-proline, CHEMBL408983, (2S)-1-[(2S)-1-[(2S,3S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-1-[(2S)-3-(1H-indol-3-yl)-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylic acid, Teprotido, Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro, AC1L9EJT, Teprotidum [INN-Latin], Teprotido [INN-Spanish], UNII-C3E5QBF1R6, Teprotide [USAN:INN:BAN], CCRIS 9333, TEPROTIDE [INN], TEPROTIDE [USAN], TEPROTIDE [MART.], SCHEMBL613757, CHEBI:9444, orb2563704, SCHEMBL11855843, HY-P2366, FB108627, SO 20881, CS-0133127, NS00125817, D06076, G77853, BPP 9a Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro-OH, Q7701390, Angiotensin Converting Enzyme Inhibitor, >=95% (TLC), Pyroglutamyl-tryptophyl-prolyl-arginyl-prolyl-glutaminyl-isoleucyl-prolyl-proline, L-Pyroglutamyl-L-tryptophyl-L-prolyl-L-arginyl-L-prolyl-L-glutaminyl-L-isoleucyl-L-prolyl-L-proline
Theoretical properties:
molecular_formula: C53H76N14O12
molecular_weight: 1101.3 g/mol
exact_mass: 1100.57671391 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 10
hydrogen_bond_acceptor_count: 13
rotatable_bond_count: 24
heavy_atom_count: 79
topological_polar_surface_area: 387 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Teprotide is a peptide.
chembl: TEPROTIDE is a protein listed in the ChEMBL database and has reached clinical trial phase 2.0.
wikipedia: Teprotide is nonapeptide which has been isolated from the snake Bothrops jararaca.  It is an angiotensin converting enzyme inhibitor (ACE inhibitor) which inhibits the conversion of angiotensin I to angiotensin II and may potentiate some of the pharmacological actions of bradykinin. It has been investigated as an antihypertension agent.