Compound: 101-68-8
SMILES: O=C=Nc1ccc(Cc2ccc(N=C=O)cc2)cc1
InChIKey: UPMLOUAZCHDJJD-UHFFFAOYSA-N
Synonyms: 101-68-8, 4,4'-Diphenylmethane diisocyanate, Diphenylmethane diisocyanate, Bis(4-isocyanatophenyl)methane, 4,4'-Methylenebis(phenyl isocyanate), Isonate, Desmodur 44, p,p'-Diphenylmethane diisocyanate, 1,1'-Methylenebis(4-isocyanatobenzene), Methylbisphenyl isocyanate, 4,4'-Methylenediphenyl diisocyanate, 4,4'-Diisocyanatodiphenylmethane, Methylene bisphenyl isocyanate, diphenylmethane-4,4'-diisocyanate, Caradate 30, Nacconate 300, Isonate 125M, Bis(p-isocyanatophenyl)methane, Diphenylmethyl diisocyanate, Isonate 125 MF, Rubinate 44, Bis(1,4-isocyanatophenyl)methane, Methylenebis(4-phenyl isocyanate), Hylene M50, Diphenylmethan-4,4'-diisocyanat, Methylenebis(4-isocyanatobenzene), Methylenebis(p-phenyl isocyanate), Benzene, 1,1'-methylenebis[4-isocyanato-, Diphenyl methane diisocyanate, 4,4'-Methylenediphenyl isocyanate, Methylenebis(p-phenylene isocyanate), Methylenedi-p-phenylene diisocyanate, Di-(4-isocyanatophenyl)methane, Difenil-metan-diisocianato, Methylenebis(4-phenylene isocyanate), 4,4'-Methylenedi-p-phenylene diisocyanate, 4,4'-Methylenediphenylene isocyanate, p,p'-Methylenebis(phenyl isocyanate), Bis(para-isocyanatophenyl)methane, NCI-C50668, Methylene di-p-phenylene isocyanate, Methylenebis(para-phenyl isocyanate), 4,4'-Methylenedi(phenyl isocyanate), 4-4'-Diisocyanate de diphenylmethane, Difenylmethaan-dissocyanaat, Methylenedi-para-phenylene diisocyanate, Methylenebis(para-phenylene isocyanate), para,para'-Diphenylmethane diisocyanate, para,para'-Methylenebis(phenyl isocyanate), Methylenebis(phenylisocyanate), 4,4'-methylene diphenyl diisocyanate, 4,4'-Methylenediphenylene diisocyanate, 4,4'-Diphenylmethanediisocyante, DTXSID7025180, B0LO6BBS8C, Isocyanic acid, ester with diphenylmethane, Nocconate 300, Methylenebisphenyl diisocyanate, CHEBI:53218, Benzene, 1,1'-methylenebis(4-isocyanato-, 4,4'-methylenebis(phenylisocyanate), 4,4'diisocyanatodiphenylmethane, DTXCID704196, Methylenebis[4-isocyanatobenzene], Methylenebis[p-phenyl isocyanate], Methylenebis[4-phenyl isocyanate], Methylenebis[4-phenylene isocyanate], Methylenebis[p-phenylene isocyanate], p,p'-Methylenebis[phenyl isocyanate], 4,4'-Methylenebis[phenyl isocyanate], methylene bis(4-phenyl isocyanate), 1,1-methylenebis(phenyl)diisocyanate, 4,4'-methylene bisphenyl diisocyanate, METHYLENEDI-P-PHENYLENE ISOCYANATE, RefChem:818588, 202-966-0, Methylene diphenyl diisocyanate, 1-isocyanato-4-[(4-isocyanatophenyl)methyl]benzene, 26447-40-5, Methylenediphenyl diisocyanate, MDI, PMDI, Diphenylmethane 4,4'-diisocyanate, 4,4'-MDI, MDR, Isocyanic acid, methylenedi-p-phenylene ester, methylenebis(phenyl isocyanate), Methylenedi-p-phenyl diisocyanate, diphenylmethan-4,4'-diisocyanate, 4,4/'-Diphenylmethane diisocyanate, MFCD00036131, Benzene, 1,1'-methylenebis(isocyanato-, Methylenedi(p-phenyl isocyanate), 4,4'-Diphenylmethanediisocyanate, Diphenylmethane p,p'-diisocyanate, 4,4'-methylenediphenyldiisocyanate, Methylenedi(p-phenylene isocyanate), NSC-9596, Methylenedi(p-phenylene diisocyanate), 4,4'-Diisocyanate de diphenylmethane, 4,4'-Methylenedi(phenylene isocyanate), Benzene, 1,1'-methylenebis[isocyanato-, Pure MDI, Generic MDI, Crude MDI, 4,?4'-?Methylenebis(phenyl Isocyanate), CCRIS 2303, HSDB 2630, 4-[(4-isocyanatophenyl)methyl]benzenisocyanate, Difenylmethaan-dissocyanaat [Dutch], NSC 9596, Difenil-metan-diisocianato [Italian], EINECS 202-966-0, EINECS 247-714-0, UNII-B0LO6BBS8C, 65916-89-4, Non-isomeric-specific MDI, BRN 0797662, Diphenylmethan-4,4'-diisocyanat [German], Isocyanic acid, methylenediphenylene ester, methylenediphenyl, AI3-15256, CCRIS 8160, 4-4'-Diisocyanate de diphenylmethane [French], 4,4'-,2,4'-,2,2'-Diisocyanatodiphenylmethane, Hylene M 50, Hylene M-50, Methylenediphenyl diisocyanate, 4,4'-, Difenylmethaan-diisocyanaat, DSSTox_CID_4196, Methylenebis(phenylisocyanate) [Diisocyanates], Epitope ID:113240, EC 202-966-0, DSSTox_RID_82371, diphenylmethylene diisocyanate, DSSTox_GSID_47473, SCHEMBL19943, WLN: OCNR D1R DNCO, 4-13-00-00396 (Beilstein Handbook Reference), UNII-6152ASV70I, SCHEMBL7946962, CHEMBL1488467, methylenebisphenylene diisocyanate, 4,4'-MDI, analytical standard, 4,4'diphenylmethane diisocyanate, Diphenylmethane 4,4-diisocyanate, NSC9596, 6152ASV70I, 4,4'- diphenylmethane diisocyanate, Methylenediphenyl 4,4'-Diisocyanate, Tox21_200268, Tox21_302585, SBB060784, AKOS000119302, Methylenebis(4,4'-phenyl isocyanate), 4,4'-Methylenedi(phenyl diisocyanate), Benzene,1'-methylenebis[4-isocyanato-, FM37903, Isocyanic acid, diphenylmethylene ester, UN 2489, NCGC00091061-01, NCGC00091061-02, NCGC00091061-03, NCGC00256765-01, NCGC00257822-01, 1,1'-Methanediylbis(4-isocyanatobenzene), CAS-101-68-8, LS-14365, 1,1'-methylenebis [4-isocyanoto benzene], CAS-9016-87-9, 4,4'-Methylenebis(phenyl isocyanate), 98%, D0897, METHYLENEDIPHENYLDIISOCYANATE, 4,4'-, NS00007848, ST50825935, 1-Isocyanato-4-(4-isocyanatobenzyl)benzene #, EN300-19009, C19453, G77505, METHYLENE BISPHENYL DIISOCYANATE [HSDB], F136500, Q417646, Diphenylmethane-4,4'-diisocyanate [UN2489]  [Keep away from food], InChI=1/C15H10N2O2/c18-10-16-14-5-1-12(2-6-14)9-13-3-7-15(8-4-13)17-11-19/h1-8H,9H
Theoretical properties:
molecular_formula: C15H10N2O2
molecular_weight: 250.25 g/mol
exact_mass: 250.074227566 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 4
rotatable_bond_count: 4
heavy_atom_count: 19
topological_polar_surface_area: 58.9 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
physical_state: Light-yellow, fused solid
color: Light-yellow, fused solid
odor: Odorless
boiling_point: 381 to 390 °F at 5 mmHg (NTP, 1992)
melting_point: 99 °F (NTP, 1992)
density: 1.2 at 68 °F (USCG, 1999) - Denser than water; will sink
solubility: Insoluble (NTP, 1992)
flash_point: 425 °F (NTP, 1992)
vapor_pressure: 5e-06 mmHg at 77 °F (NIOSH, 2024)
Descriptions:
pubchem: Diphenylmethane-4,4'-diisocyanate is a diisocyanate consisting of diphenylmethane with two isocyanate groups at the 4- and 4'-positions. It has a role as an allergen and a hapten. It derives from a hydride of a diphenylmethane.
chebi: A diisocyanate consisting of diphenylmethane with two isocyanate groups at the 4- and 4'-positions.
chembl: Unnamed Compound is a small molecule listed in the ChEMBL database but has not progressed to an approved clinical phase.
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The film premiered in London on January 28, 2026, and was released in the United States by Amazon MGM Studios and internationally by Sony Pictures Releasing International on February 13, 2026. It received positive reviews from critics but was a box-office bomb, grossing $72.7 million worldwide on a budget of $90 million.