Compound: BRADYKININ
SMILES: O=C(N1[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N2[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CCCN=C(N)N)Cc3ccccc3)CCC2)CO)Cc4ccccc4)CCC1)[C@H]5N(C(=O)[C@@H](N)CCCN=C(N)N)CCC5
InChIKey: QXZGBUJJYSLZLT-FDISYFBBSA-N
Synonyms: BRADYKININ, 58-82-2, L-Bradykinin, Kallidin I, Callidin I, Kallidin-9, (2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid, BRS-640, Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg, S8TIM42R2W, CHEBI:3165, DTXSID50893681, (2S)-2-(((2S)-2-(((2S)-1-((2S)-2-(((2S)-2-((2-(((2S)-1-((2S)-1-((2S)-2-amino-5-(diaminomethylideneamino)pentanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carbonyl)amino)acetyl)amino)-3-phenylpropanoyl)amino)-3-hydroxypropanoyl)pyrrolidine-2-carbonyl)amino)-3-phenylpropanoyl)amino)-5-(diaminomethylideneamino)pentanoic acid, (2S)-2-((2S)-2-(((2S)-1-((2S)-2-((2S)-2-(2-(((2S)-1-(((2S)-1-((2S)-2-amino-5-carbamimidamidopentanoyl)pyrrolidin-2-yl)carbonyl)pyrrolidin-2-yl)formamido)acetamido)-3-phenylpropanamido)-3-hydroxypropanoyl)pyrrolidin-2-yl)formamido)-3-phenylpropanamido)-5-carbamimidamidopentanoic acid, (2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-(2-{[(2S)-1-{[(2S)-1-[(2S)-2-amino-5-carbamimidamidopentanoyl]pyrrolidin-2-yl]carbonyl}pyrrolidin-2-yl]formamido}acetamido)-3-phenylpropanamido]-3-hydroxypropanoyl]pyrrolidin-2-yl]formamido}-3-phenylpropanamido]-5-carbamimidamidopentanoic acid, RefChem:388840, DTXCID501323800, Arg Pro Pro Gly Phe Ser Pro Phe Arg, 200-398-8, Synthetic bradykinin, Kallidin 9, Bradykinin (synthetic), BRS 640, PRS 640, Bradykinin Acetate, MFCD00076258, CHEMBL406291, L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-arginine, Bradykinin Trifluoroacetic Acid, C50H73N15O11, Arg1-Pro2-Pro3-Gly4-Phe5-Ser6-Pro7-Phe8-Arg9, UNII-S8TIM42R2W, bradykinine, [3H]-bradykinin, kinin 9, L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-arginine Trifluoroacetic Acid, EINECS 200-398-8, RPPGFSPFR, Bradykinin (8CI,9CI), GTPL649, GTPL3812, orb1296680, SCHEMBL3047797, SCHEMBL7949684, [3H]BK (human, mouse, rat), [3H]-BK, HY-P0206, BDBM50049949, HB3101, AKOS024457374, AT31964, CS-6356, DB12126, EBC-157262, NCGC00167139-01, AS-78307, DA-71701, NS00074081, C00306, (BK) H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH, Q24745328, Z2724205382, L-Arg-L-Pro-L-Pro-Gly-L-Phe-L-Ser-L-Pro-L-Phe-L-Arg, H-L-Arg-L-Pro-L-Pro-Gly-L-Phe-L-Ser-L-Pro-L-Phe-L-Arg-OH, (2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-1-[(2S)-2-amino-5-guanidino-pentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-phenyl-propanoyl]amino]-3-hydroxy-propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenyl-propanoyl]amino]-5-guanidino-pentanoic acid, (bradykinin triacetate)2-(2-{[1-(2-{2-[2-({1-[1-(2-Amino-5-guanidino-pentanoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonyl}-amino)-acetylamino]-3-phenyl-propionylamino}-3-hydroxy-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionylamino)-5-guanidino-pentanoic acid, 2-(2-{[1-(2-{2-[2-({1-[1-(2-Amino-5-guanidino-pentanoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonyl}-amino)-acetylamino]-3-phenyl-propionylamino}-3-hydroxy-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionylamino)-5-guanidino-pentanoic acid, 2-(2-{[1-(2-{2-[2-({1-[1-(2-Amino-5-guanidino-pentanoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonyl}-amino)-acetylamino]-3-phenyl-propionylamino}-3-hydroxy-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionylamino)-5-guanidino-pentanoic acid(Bradykinin), Arginine, N2-[N-[1-[N-[N-[N-[1-(1-arginyl-L-prolyl)-L-prolyl]glycyl]-3-phenylalanyl]seryl]prolyl]-3-phenylalanyl]- (6CI), L-Arginine, L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-
Theoretical properties:
molecular_formula: C50H73N15O11
molecular_weight: 1060.2 g/mol
exact_mass: 1059.56139820 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 12
hydrogen_bond_acceptor_count: 14
rotatable_bond_count: 27
heavy_atom_count: 76
topological_polar_surface_area: 419 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Bradykinin is a linear nonapeptide messenger belonging to the kinin group of proteins, with amino acid sequence RPPGFSPFR. Enzymatically produced from kallidin in the blood, it is a powerful vasodilator that causes smooth muscle contraction, and may mediate inflammation. It has a role as a vasodilator agent and a human blood serum metabolite. It is a conjugate base of a bradykinin(2+).
chebi: A linear nonapeptide messenger belonging to the kinin group of proteins, with amino acid sequence RPPGFSPFR. Enzymatically produced from kallidin in the blood, it is a powerful vasodilator that causes smooth muscle contraction, and may mediate inflammation.
chembl: BRADYKININ is a protein listed in the ChEMBL database and has reached clinical trial phase 2.0.
wikipedia: Bradykinin (BK) (from Greek brady- 'slow' + -kinin, kīn(eîn) 'to move') is a peptide that promotes inflammation. It causes arterioles to dilate (enlarge) via the release of prostacyclin, nitric oxide, and endothelium-derived hyperpolarizing factor, and makes veins constrict via prostaglandin F2, thereby leading to leakage into capillary beds due to the increased pressure in the capillaries. Bradykinin consists of nine amino acids, and is a physiologically and pharmacologically active peptide of the kinin group of proteins.
A class of drugs called angiotensin-converting-enzyme inhibitors (ACE inhibitors) increase bradykinin levels by inhibiting its degradation, thereby increasing its blood pressure-lowering effect. ACE inhibitors are used to treat hypertension and heart failure.