Compound: CEPHARANTHINE
SMILES: O1c2c3c(cc4c2OCO4)CCN([C@H]3Cc5ccc(Oc6cc(C[C@@H]7c8cc1c(OC)cc8CCN7C)ccc6OC)cc5)C
InChIKey: YVPXVXANRNDGTA-WDYNHAJCSA-N
Synonyms: CEPHARANTHINE, 481-49-2, (+)-Cepharanthine, NSC-623442, DTXSID6045957, 6',12'-Dimethoxy-2,2'-dimethyl-6,7-(methylenebis(oxy))oxyacanthan, CHEBI:3546, 7592YJ0J6T, (14S,27R)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.216,19.13,10.121,25.04,8.031,35.014,39]nonatriaconta-1(33),3(39),4(8),9,16(38),17,19(37),21,23,25(36),31,34-dodecaene, DTXCID4025957, (14S,27R)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo(25.6.2.216,19.13,10.121,25.04,8.031,35.014,39)nonatriaconta-1(33),3(39),4(8),9,16(38),17,19(37),21,23,25(36),31,34-dodecaene, RefChem:124431, 683-114-9, Cepharanthin, O-Methylcepharanoline, Cepharantin, Cepharanthine [JAN], MFCD00210482, C37H38N2O6, 4,37-dodecaene, NSC623442, Cepharanthine (JAN), Oxyacanthan, 6',12'-dimethoxy-2,2'-dimethyl-6,7-(methylenebis(oxy))-, ecaene (non-preferred name), (15S,31R)-36,54-Dimethoxy-16,32-dimethyl-15,16,17,18,31,32,33,34-octahydro-2,6-dioxa-1(4,5)-[1,3]dioxolo[4,5-g]isoquinolina-3(7,1)-isoquinolina-5(1,3),7(1,4)-dibenzenacyclooctaphane, CAS-481-49-2, CCRIS 6539, SR-01000779734, 22,33-Dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.216,19.13,10.121,25.04,8.031,35.014,39]nonatriaconta-1(33),3(39),4(8),9,16(38),17,19(37),21,23,25(36),31,34-dodecaene, NSC 623442, BRN 0075231, UNII-7592YJ0J6T, NCGC00095194-01, (14S,27R)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2^{16,19}.1^{3,10}.1^{21,25}.0^{4,8}.0^{31,35}.0^{14,39}]nonatriaconta-1(33),3(39),4(8),9,16,18,21,23,25(36),31,3, (14S,27R)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2~16,19~.1~3,10~.1~21,25~.0~4,8~.0~14,39~.0~31,35~]nonatriaconta-1(33),3,8,10(39),16,18,21(36),22,24,31,34,37-dod, Ex Cepharantha tuber, Cepharanthine (Standard), Spectrum2_000832, Spectrum3_001963, CEPHARANTHINE [MI], Epitope ID:534820, UPCMLD-DP054, BSPBio_003563, 4-27-00-09061 (Beilstein Handbook Reference), MLS000728518, SCHEMBL154545, SPECTRUM1505322, SPBio_000783, CEPHARANTHINE [WHO-DD], CHEMBL449782, orb1310907, SCHEMBL29378091, SCHEMBL29381295, SCHEMBL30562981, UPCMLD-DP054:001, HY-N6972R, KBio3_002909, Cepharanthine, >=95% (HPLC), Cepharanthine, >=98% (HPLC), HMS1922J12, HMS2232F21, Pharmakon1600-01505322, HY-N6972, Tox21_111483, BBL030154, BDBM50423643, CCG-40294, EBC-17163, NSC758965, s4238, STK801907, AKOS004119865, Tox21_111483_1, FC66045, NSC-758965, SDCCGMLS-0066893.P001, NCGC00161621-01, NCGC00161621-02, NCGC00161621-03, NCGC00161621-05, NCGC00161621-09, NCGC00161621-13, AC-15206, AS-17451, DA-51781, SMR000445632, SY068840, SBI-0207049.P001, CS-0007138, M2968, C09391, D01035, AB00643356_08, AB00643356_09, SR-01000779734-3, SR-01000779734-4, BRD-K96194081-001-06-0, BRD-K96194081-001-10-2, BRD-K96194081-001-11-0, Q15410888, (1~5~S,3~1~R)-3~6~,5~4~-Dimethoxy-1~6~,3~2~-dimethyl-1~5~,1~6~,1~7~,1~8~,3~1~,3~2~,3~3~,3~4~-octahydro-1~2~H-2,6-dioxa-1(4,5)-[1,3]dioxolo[4,5-g]isoquinolina-3(7,1)-isoquinolina-5(1,3),7(1,4)-dibenzenacyclooctaphane, (14S,27R)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2(16,19).1(3,10).1(21,25).0(4,8).0(14,39).0(31,35)]nonatriaconta-1(33),3,8,10(39),16,18,21(36),22,24,31,34,37-dodecaene, (14S,27R)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2??,??.1?,??.1??,??.0?,?.0??,??.0??,??]nonatriaconta-1(33),3,8,10(39),16,18,21(36),22,24,31,34,37-dodecaene, (14S,27R)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2^{16,19}.1^{3,10}.1^{21,25}.0^{4,8}.0^{31,35}.0^{14,39}]nonatriaconta-1(33),3(39),4(8),9,16,18,21,23,25(36),31,34,37-dodecaene
Theoretical properties:
molecular_formula: C37H38N2O6
molecular_weight: 606.7 g/mol
exact_mass: 606.27298694 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 8
rotatable_bond_count: 2
heavy_atom_count: 45
topological_polar_surface_area: 61.9 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Cepharanthine is a bisbenzylisoquinoline alkaloid from tubers of Stephania; stimulates recovery of immunologic function in lymphatic system after administration of antineoplastic agents or x-irradiation. It is a bisbenzylisoquinoline alkaloid and a member of isoquinolines.
chebi: A bisbenzylisoquinoline alkaloid from tubers of <em>Stephania</em>; stimulates recovery of immunologic function in lymphatic system after administration of antineoplastic agents or x-irradiation.
chembl: CEPHARANTHINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 2.0.
wikipedia: Cepharanthine is an antiinflammatory and antineoplastic compound isolated from Stephania. Due to these modalities, it has been shown effective against HTLV in lab research.  Additionally, it has successfully been used to treat a diverse range of medical conditions, including radiation-induced leukopenia, idiopathic thrombocytopenic purpura, alopecia areata, alopecia pityrodes, venomous snakebites, xerostomia, sarcoidosis, refractory anemia and various cancer-related conditions. No safety issues have been observed with CEP, and side effects are very rarely reported.