Compound: SKF 38393
SMILES: Oc1c(O)cc2CCNCC(c2c1)c3ccccc3
InChIKey: JUDKOGFHZYMDMF-UHFFFAOYSA-N
Synonyms: SKF 38393, 67287-49-4, SKF-38393, SK&F-38393, 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, SK&F 38393, 2,3,4,5-Tetrahydro-1-phenyl-1H-3-benzazepine-7,8-diol, 1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-1-phenyl-, SKF38393, R7TF327S2C, SKF-38,393, SKF 38393-A, RSK&F 38393, SKF 38393 A, SK&F38393, RefChem:388746, CHEBI:131793, SKF-38393, (A+-)-, SKF-38393 free base, 1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol, 5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, CHEMBL286080, 6-PHENYL-4-AZOBICYCLO[5.4.0]UNDECA-7,9,11-TRIENE-9,10-DIOL, 1-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol, Biomol-NT_000034, BRN 1543419, DTXSID10894836, SK&F-383933, 67287-49-4 (free base), (+/-)-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol; (+/-)-SKF 38393; 2,3,4,5-Tetrahydro-1-phenyl-1H-3-benzazepine-7,8-diol; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, SK-38393, SK-383933, UNII-R7TF327S2C, Lopac0_000436, BSPBio_002384, GTPL935, 5-21-05-00258 (Beilstein Handbook Reference), SCHEMBL469578, SPECTRUM1505101, BPBio1_001229, cid_147514, SCHEMBL29389401, CHEBI:110200, CHEBI:131801, (+/-)-1-phenyl-2,3,4,5-tetrahydro-(1h)-3-benzazepine-7,8-diol, BDBM50004923, PDSP1_001524, PDSP2_001508, R(+)SKF38393, (A+/-)-SKF-38393 hydrochloride, AKOS040749511, CCG-204528, SDCCGSBI-0050421.P002, NCGC00015299-03, NCGC00015299-04, NCGC00015299-05, NCGC00015299-06, NCGC00015299-07, NCGC00015299-11, NCGC00024875-02, NCGC00024875-03, NCGC00024875-04, NCG-C00093856-01, DB-217527, (+/-)-SKF-38393, (+/-)- SKF 38393, SKF-38393, (+/-)-, L000563, Q7390598, BRD-A88548664-001-02-3, BRD-A88548664-004-01-9, BRD-A88548664-004-02-7, 1-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol (SK&F 38393), 1-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol(SKF 38393), 1-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol; hydrochloride(SKF 38393), RS(+/-)SKF 383931-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol, ()-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol; ()-SKF 38393; 2,3,4,5-Tetrahydro-1-phenyl-1H-3-benzazepine-7,8-diol; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
Theoretical properties:
molecular_formula: C16H17NO2
molecular_weight: 255.31 g/mol
exact_mass: 255.125928785 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 3
hydrogen_bond_acceptor_count: 3
rotatable_bond_count: 1
heavy_atom_count: 19
topological_polar_surface_area: 52.5 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: 1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol is a benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine bearing a phenyl substituent at position 1 and two hydroxy substituents at positions 7 and 8. It is a member of catechols, a benzazepine and a secondary amino compound.
chebi: A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine bearing a phenyl substituent at position 1 and two hydroxy substituents at positions 7 and 8.
chembl: SKF-38393 is a small molecule listed in the ChEMBL database but has not progressed to an approved clinical phase.
wikipedia: SKF-38393 is a synthetic compound of the 3-benzazepine family which acts as a selective dopamine D1 and D5 receptor partial agonist. It has stimulant and anorectic effects.
The trimethylation of SKF-38,393 leads to a named agent called trepipam. As with fenoldopam, the inclusion of a chlorine halogen gave an agent that is called SKF-81,297.