Compound: Carglumic acid
SMILES: O=C(N[C@H](C(=O)O)CCC(=O)O)N
InChIKey: LCQLHJZYVOQKHU-VKHMYHEASA-N
Synonyms: Carglumic acid, 1188-38-1, N-Carbamyl-L-glutamic acid, Carbaglu, N-Carbamoyl-L-glutamic acid, (2S)-2-(carbamoylamino)pentanedioic acid, Ureidoglutaric acid, Carbamylglutamic acid, Carbamino-L-glutamic acid, L-N-Carbamoylglutamic acid, acido carglumico, acide carglumique, L-Glutamic acid, N-(aminocarbonyl)-, acidum carglumicum, 5L0HB4V1EW, OE-312, DTXSID7046706, OE 312, NSC-760124, DTXCID5026706, CHEBI:71028, CarglumicAcid, RefChem:57054, 601-569-3, (S)-2-ureidopentanedioic acid, N-Carbamylglutamate, N-Carbamyl-L-glutamate, carbamylglutamate, MFCD00047874, N-Cbm-Glu-OH, OE312, OE 312 (LABORATORY CODE DESIGNATION), Carglumic acid [INN], N-Carbamyl-glutamic Acid, Carbaglu (TN), CAS-1188-38-1, N-(Aminocarbonyl)-L-glutamic acid(carglumic acid), UNII-5L0HB4V1EW, Carglumic acid [USAN:INN], carglumic-acid, (2S)-2-ureidopentanedioic acid, L-Carglumic acid, Glutamic acid, N-carbamoyl-, L-, NCGC00167549-01, CARGLUMIC ACID [MI], CARGLUMIC ACID [JAN], CARGLUMIC ACID [USAN], SCHEMBL373546, CARGLUMIC ACID [VANDF], GTPL7458, orb1310321, CARBAMYL-L-GLUTAMIC ACID, CARGLUMIC ACID [MART.], CARGLUMIC ACID [USP-RS], CARGLUMIC ACID [WHO-DD], CHEMBL1201780, N-(Aminocarbonyl)-glutamic acid, NCG,N-carbamyl-L-glutamic acid, Carglumic acid (JAN/USAN/INN), CARGLUMIC ACID [EMA EPAR], HY-B0711, Tox21_112544, CARGLUMIC ACID [ORANGE BOOK], EBC-12537, s5301, SBB066020, AKOS010384789, Tox21_112544_1, CS-8208, DB06775, NSC 760124, NCGC00274073-01, DS-17934, FC172405, SY317362, DB-298497, NS00008491, (2S)-2-(aminocarbonylamino)pentanedioic acid, C05829, D07130, EN300-122612, F216659, Q822884, (S)-2-((hydroxy(imino)methyl)amino)pentanedioic acid, BRD-K60240222-001-01-4, Z756468010, Carglumic Acid, United States Pharmacopeia (USP) Reference Standard
Theoretical properties:
molecular_formula: C6H10N2O5
molecular_weight: 190.15 g/mol
exact_mass: 190.05897142 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 4
hydrogen_bond_acceptor_count: 5
rotatable_bond_count: 5
heavy_atom_count: 13
topological_polar_surface_area: 130 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Carglumic acid is a urea that is the N-carbamoyl derivative of L-glutamic acid. An orphan drug used to treat a deficiency in the enzyme N-acetylglutamate synthase, which leads to acute hyperammonaemia. It has a role as an orphan drug and a carbamylphosphate synthetase I activator. It is a N-acyl-L-glutamic acid and a member of ureas. It is a conjugate acid of a N-carbamoyl-L-glutamate(2-).
chebi: A urea that is the <em>N</em>-carbamoyl derivative of <small>L</small>-glutamic acid. An orphan drug used to treat a deficiency in the enzyme <em>N</em>-acetylglutamate synthase, which leads to acute hyperammonaemia.
chembl: CARGLUMIC ACID is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Carglumic acid, sold under the brand name Carbaglu among others, is used for the treatment of hyperammonaemia. Carglumic acid is a carbamoyl phosphate synthetase 1 (CPS 1) activator.
The most common adverse effects include vomiting, abdominal pain, pyrexia (fever), and tonsillitis, anemia, diarrhea, ear infection, other infections, nasopharyngitis, decreased hemoglobin levels, and headache.
It was approved for medical use in the United States in March 2010. Carglumic acid is an orphan drug. It is available as a generic medication.