Compound: MPEP
SMILES: n1c(C#Cc2ccccc2)cccc1C
InChIKey: NEWKHUASLBMWRE-UHFFFAOYSA-N
Synonyms: MPEP, 96206-92-7, 2-Methyl-6-(phenylethynyl)pyridine, 2-methyl-6-(2-phenylethynyl)pyridine, 6-Methyl-2-(phenylethynyl)pyridine, 7VC0YVI27Y, DTXSID7042564, CHEBI:64159, MPEP cpd, RefChem:88204, DTXCID7023982, Pyridine, 2-methyl-6-(phenylethynyl)-, MFCD03787983, CHEMBL66654, 2-methyl-6-(phenylethynyl)-pyridine, Tocris-1212, MPEP?, Lopac-M-5435, UNII-7VC0YVI27Y, Lopac0_000738, MLS006011229, SCHEMBL103061, 2-Picoline, 6-phenylethynyl-, GTPL1426, SCHEMBL29355216, 2-Methyl-6-phenylethynyl-pyridine, GLXC-05143, HMS3651F13, HMS3884D18, HMS5081N17, ALBB-016135, EX-A5620, 2-methyl-6-(phenyl-ethynyl)pyridine, BDBM50084137, HY-14609A, s2809, 6-methyl-2-(2-phenylethynyl)pyridine, AKOS006275850, CCG-204823, CS-0794, FM66689, SDCCGSBI-0050716.P002, Pyridine, 6-methyl-2-(phenylethynyl)-, NCGC00015682-01, NCGC00015682-02, NCGC00015682-03, NCGC00015682-04, NCGC00015682-05, NCGC00015682-13, NCGC00025044-01, NCGC00025044-02, NCGC00025044-03, 2-Methyl-6-phenylethynyl-pyridine(MPEP), SMR004702989, SY122281, [3H]-2-methyl-6-(phenylethynyl)-pyridine, 2-methyl-6-(phenylethynyl)pyridine (mpep), SW219533-1, H11580, F787561, L000408, Q4596902, BRD-K60690191-001-03-3, BRD-K60690191-003-02-1, BRD-K60690191-003-09-6, F2167-5303
Theoretical properties:
molecular_formula: C14H11N
molecular_weight: 193.24 g/mol
exact_mass: 193.089149355 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 1
rotatable_bond_count: 2
heavy_atom_count: 15
topological_polar_surface_area: 12.9 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
{"pubchem": "2-methyl-6-(phenylethynyl)pyridine is a methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw. It has a role as an anxiolytic drug and a metabotropic glutamate receptor antagonist. It is a member of methylpyridines and an acetylenic compound. It is a conjugate base of a 2-methyl-6-(phenylethynyl)pyridinium(1+). It derives from a hydride of an acetylene.", "chebi": "A methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu<small><sub>5</sub></small> receptor subtype (IC<small><sub>50</sub></small> = 36 nM) and a positive allosteric modulator at mGlu<small><sub>4</sub></small> receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.", "chembl": "Unnamed Compound is a small molecule listed in the ChEMBL database but has not progressed to an approved clinical phase.", "wikipedia": "The Manual of Patent Examining Procedure (MPEP) is published by the United States Patent and Trademark Office (USPTO) for use by patent attorneys and agents and patent examiners.  It describes all of the laws and regulations that must be followed in the examination of U.S. patent applications, and articulates their application to an enormous variety of different situations.  The MPEP is based on Title 37 of the Code of Federal Regulations, which derives its authority from Title 35 of the United States Code, as well as on case law arising under those titles.  The origins of the Manual date back to a 1920 Patent and Trademark Office Society publication known as the \"Wolcott Manual\". \"One of the most fruitful endeavors of the [Patent and Trademark Office] Society in the area of education was the publication of the first Manual of Patent Office Procedure. The first Manual was written by two employees of the Office and was published in 1920 by the Society. This Manual, with its eight revisions, often referred to as Wolcott's Manual, was the only procedural manual available until 1949 when the Patent Office assumed the publication of the Manual of Patent Examining Procedure.\"\nThe MPEP is used extensively by patent attorneys, agents, and examiners to help make sure the proper USPTO regulations are followed.  The USPTO registration examination tests knowledge of the MPEP and the underlying laws and regulations.\nThe MPEP is available in both PDF and HTML versions.  The current version of the MPEP is the 9th Edition, which was released in March 2014. The MPEP has traditionally been available in paper form, but electronic versions are now used more often, particularly because an applicant only may consult the electronic versions while taking the USPTO registration examination, or the patent bar examination. As of March, 2014 the patent bar examination tests the 9th Edition.\nThe MPEP provides guidance to members of the public on how to present persuasive arguments to a patent examiner as to why a patent should be granted on a given patent application.  See in particular Chapter 2100 on patentability."}