Compound: imidapril
SMILES: O=C1N(C(=O)[C@@H](N[C@H](C(=O)OCC)CCc2ccccc2)C)[C@H](C(=O)O)CN1C
InChIKey: KLZWOWYOHUKJIG-BPUTZDHNSA-N
Synonyms: imidapril, 89371-37-9, Imidaprilum, Hipertene, Tanatril, BW7H1TJS22, (4S)-3-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid, (S)-3-(N-((S)-1-Ethoxycarbonyl-3-phenylpropyl)-L-alanyl)-1-methyl-2-oxoimidazoline-4-carboxylic acid, DTXSID2048242, CHEBI:135654, (4S)-3-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid, (4S)-3-((2S)-2-(((2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid, RefChem:147954, DTXCID3028217, C09AA16, 1-methyl-3-(2-(N-(1-ethoxycarbonyl-3-phenylpropyl)amino)propionyl)-2-oxoimidazolidine-4-carboxylic acid, CHEMBL317094, Imidapril (INN), (S)-3-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid, IMIDAPRIL [INN], Imidaprilum [INN-Latin], (4S)-3-{N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl}-1-methyl-2-oxoimidazolidine-4-carboxylic acid, Imidapril [INN:BAN], NCGC00181342-01, UNII-BW7H1TJS22, Hipertene (TN), IMIDAPRIL [MI], IMIDAPRIL [WHO-DD], SCHEMBL34098, GTPL6377, orb1688032, HY-B1451A, BDBM50020400, EX-A12667, AKOS015967028, DB11783, NCGC00181342-03, NCGC00181342-05, AC-25844, CS-0137517, NS00007217, D08068, H55322, AB01565810_02, Q1041804, (4S)-1-methyl-3-[(2S)-2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)amino]propionyl]-2-oxo-imidazolidine-4-carboxylic acid, 3-[2-(1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-1-methyl-2-oxo-imidazolidine-4-carboxylic acid
Theoretical properties:
molecular_formula: C20H27N3O6
molecular_weight: 405.4 g/mol
exact_mass: 405.18998559 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 2
hydrogen_bond_acceptor_count: 7
rotatable_bond_count: 10
heavy_atom_count: 29
topological_polar_surface_area: 116 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Imidapril is a member of the class of imidazolidines that is (4S)-1-methyl-2-oxoimidazolidine-4-carboxylic acid in which the hydrogen of the imidazolidine nitrogen has been substituted by (1S)-1-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}ethyl group. It is the prodrug for imidaprilat, an ACE inhibitor used for the treatment of chronic heart failure. It has a role as an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor, an antihypertensive agent and a prodrug. It is an ethyl ester, a dicarboxylic acid monoester, a member of imidazolidines, a dipeptide, a secondary amino compound and a N-acylurea.
chebi: A member of the class of imidazolidines that is (4<i>S</i>)-1-methyl-2-oxoimidazolidine-4-carboxylic acid in which the hydrogen of the imidazolidine nitrogen has been substituted by (1<i>S</i>)-1-{[(2<i>S</i>)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}ethyl group. It is the prodrug for imidaprilat, an ACE inhibitor used for the treatment of chronic heart failure.
chembl: IMIDAPRIL is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Imidapril, sold under the brand name Tanatril among others, is an ACE inhibitor used as an antihypertensive drug and for the treatment of chronic heart failure.
It was patented in 1982 and approved for medical use in 1993.