Compound: TROLAMINE SALICYLATE
SMILES: O=C(O)c1c(O)cccc1.OCCN(CCO)CCO
InChIKey: UEVAMYPIMMOEFW-UHFFFAOYSA-N
Synonyms: TROLAMINE SALICYLATE, Triethanolamine salicylate, 2174-16-5, TEA-Salicylate, TEA salicylate, Neo heliopan ts, Neotan w, Arthricream, H8O4040BHD, DTXSID4047969, Trolamine salicylate (USP), DTXCID4027945, Trolamine salicylate [USP], Cannaflex, Hempvana, Arthritis Cream, Arthritis Leader, Arthritis Relief, Asper-Flex, Asper-Flex Cream, Trolamin Salicylate, Arthritis with Aloe, Hempvana Pain Relief, Arthricream with Aloe, DCH Arthritis Relief, XCEPTOL PAIN, Copperlife Pain Relief, CBD Pain Relief Cream, RefChem:56182, Warrior Arthritis Relief, Arthritis with Aloe CVS, Aspercreme Pain Relieving, KRT Athletic Muscle Gel, Trolamin Salicylate 10%, Trolamine Salicylate 10%, Meijer Analgesic with Aloe, Meijer Pain Relieving Balm, Dermachange Arthritis Relief, XCEPTOL PAIN UNSCENTED, Blue-Emu Maximum Pain Relief, teds topical pain gel roll on, CannEssentia Pain Relief Cream, Alcis Daily Relief Pain Relief, Blue-Emu Ultra with Hemp Seed, Pain Relieving Topical Analgesic, XCEPTOR CBD PAIN LAVENDER, Arthritis Relief Maximum Strength, Blue-Emu Pain Relief Micro-Foam, XCEPTOR CBD PAIN UNSCENTED, Equate Odor-Free Therapy Arthritis, Meijer Pain Relieving Balm Analgesic, Hempvana Maximum Strength Pain Relief, Good Neighbor Pharmacy Arthritis Cream, Leader Maximum Strength Pain Relieving, Maximum Strength Blue Emu Pain Relief, Walgreens Pain Relieving Plus Turmeric, Tommie Copper Pain Relief Maximum Strength, Equate Odor-Free Therapy Arthritis Analgesic, Meijer Analgesic with Aloe Topical Analgesic, Real Time Pain Relief Therapeutic Hand Cream, Hempvana Maximum Strength Pain Relief-Platinum, Maximum Strength Blue Emu Pain Relief Blu Emu, Kroger Odor Free Arthricream Rub Pain Relieving, Leader Maximum Strength Pain Relieving Analgesic, Walgreens Pain Relieving Plus Turmeric Analgesic, 2-(bis(2-hydroxyethyl)amino)ethan-1-ol; 2-hydroxybenzoic acid, Hempvana Maximum Strength Pain Relief Cream 10% Trolamine Salicylate, 218-531-3, salicylic acid triethanolamine salt, Salicylic acid trolamine, 2-[bis(2-hydroxyethyl)amino]ethanol;2-hydroxybenzoic acid, Myoflex, Sunarome W, Arthricream (TN), MFCD00082325, UNII-H8O4040BHD, SCHEMBL15847, Salicylic acid triethanolamine, SCHEMBL5874177, CHEMBL2107288, TRIETHANOLAMINE, SALICYLATE, UEVAMYPIMMOEFW-UHFFFAOYSA-N, EINECS 218-531-3, Tox21_201084, TROLAMINE SALICYLATE [MART.], TROLAMINE SALICYLATE [WHO-DD], DB11079, TRIETHANOLAMINE SALICYLATE [MI], NCGC00248985-01, NCGC00258636-01, TRIETHANOLAMINE SALICYLATE [VANDF], CAS-2174-16-5, TROLAMINE SALICYLATE [USP IMPURITY], DB-257169, TROLAMINE SALICYLATE [USP MONOGRAPH], NS00083243, ST50405492, D08501, Q7845153, 2,2',2''-nitrilotris(ethan-1-ol) 2-hydroxybenzoate, 2-hydroxybenzoic acid, 2-[bis(2-hydroxyethyl)amino]ethan-1-ol, 2-Hydroxybenzoic acid--2,2',2''-nitrilotri(ethan-1-ol) (1/1), Salicylic acid, compound with 2,2',2''-nitrilotriethanol (1:1)
Theoretical properties:
molecular_formula: C13H21NO6
molecular_weight: 287.31 g/mol
exact_mass: 287.13688739 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 5
hydrogen_bond_acceptor_count: 7
rotatable_bond_count: 7
heavy_atom_count: 20
topological_polar_surface_area: 121 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 2
Physical properties:
boiling_point: Decomposes
solubility: Soluble
Descriptions:
{"pubchem": null, "chebi": null, "chembl": "TROLAMINE SALICYLATE is a small molecule listed in the ChEMBL database and has reached clinical trial phase -1.0.", "wikipedia": "Trolamine salicylate (Aspercreme, Aspergel) is an organic compound with the chemical formula [HN(CH2CH2OH)3]+C6H4(OH)(COO\u2212). It is a salt of triethanolamine and salicylic acid, i.e. the compound consists of protonated triethanolamine and the conjugate base of salicylic acid, salicate.\nIt is used as an ingredient in sunscreens, analgesic creams, and cosmetics. The salicylic acid portion contributes to both the sun protection effect (by absorbing UVB radiation) and to the analgesic effect. The triethanolamine neutralizes the acidity of the salicylic acid. One benefit of this topical analgesic is that it has no odor, in contrast to other topical analgesics such as menthol.\nThe US Food and Drug Administration has not reviewed any of the over-the-counter products listed in the Daily Med database that contain trolamine salicylate. Also, the producers of trolamine salicylate products have not provided evidence to the FDA in support of claims that this chemical is directly absorbed through the skin into underlying tissue. Due to health concerns, in 2019 the FDA issued a proposed rule classifying the sunscreen use of trolamine salicylate as \"not generally recognized as safe and effective.\" One study reported that trolamine salicylate does penetrate into, and persist within, underlying muscle tissue. The test subjects used either the trolamine salicylate product or a placebo while engaging in an exercise regimen designed to induce muscle soreness. The experimenters observed that those using the trolamine salicylate product exercised longer before reporting the onset of soreness, reported less intense soreness, and reported that their soreness did not last as long as the people who used the placebo.\nAll of the trolamine salicylate-containing products listed in the two cited references are 10% solutions. These products are sold under various brand names, e.g. Aspercreme, and are marketed as topical analgesics for temporary relief of arthritis, simple backache, muscle strains, and sprains."}