Compound: terazosin
SMILES: O=C(N1CCN(c2nc(N)c3cc(OC)c(cc3n2)OC)CC1)C4OCCC4
InChIKey: VCKUSRYTPJJLNI-UHFFFAOYSA-N
Synonyms: terazosin, 63590-64-7, Terazosine, Fosfomic, Terazosina, Blavin, Flumarc, Terazosinum, Terazosabb, 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine, Hytrinex, Vicard, 8L5014XET7, CHEBI:9445, DTXSID3023639, Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)-, 6,7-dimethoxy-2-(4-((oxolan-2-yl)carbonyl)piperazin-1-yl)quinazolin-4-amine, 6,7-dimethoxy-2-(4-(oxolane-2-carbonyl)piperazin-1-yl)-3,4-dihydroquinazolin-4-imine, 6,7-dimethoxy-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]-3,4-dihydroquinazolin-4-imine, 6,7-dimethoxy-2-{4-[(oxolan-2-yl)carbonyl]piperazin-1-yl}quinazolin-4-amine, RefChem:57178, DTXCID003639, G04CA03, terazosin, monohydrochloride, dihydrate, Vasomet, Hytrin, Terazosine [INN-French], Terazosinum [INN-Latin], Terazosina [INN-Spanish], C19H25N5O4, 141269-45-6, Terazosin (INN), 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine, 6,7-dimethoxy-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]quinazolin-4-amine, [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone, CHEMBL611, MLS000069703, Terazosin (hydrochloride), Dysalfa, Adecur, Deflox, SMR000058309, TERAZOSIN [INN], Terazosin [INN:BAN], 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-{(tetnaphydro-2-furanyl)carbonyl}piperazine, 6,7-dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine, 6,7-Dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine hydrochloride, 141269-44-5, Abbott 45975, (4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(tetrahydrofuran-2-yl)methanone, [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](tetrahydrofuran-2-yl)methanone, Terazosabb (TN), terazosin a, UNII-8L5014XET7, Apo-Terazosin, TERAZOSIN [MI], 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]piperazine hydrochloride, 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)4-[(tetrahydro-2-furanyl)carbonyl]piperazine hydrochloride, Opera_ID_1910, Prestwick0_000751, Prestwick1_000751, Prestwick2_000751, Prestwick3_000751, GlyTouCan:G30025JM, TERAZOSIN [VANDF], SCHEMBL6528, TERAZOSIN [WHO-DD], Lopac0_001138, REGID_for_CID_5401, BSPBio_000762, MLS001201836, MLS006011889, SPBio_002701, BPBio1_000840, GTPL7302, orb1688307, SCHEMBL30684952, HMS2090P21, HMS2232N21, HMS3259F04, HMS3369P14, HMS3371E20, HMS3742I09, G30025JM, HY-B0371, JEA35134, BBL010743, BDBM50033111, EBC-07365, STK567029, AKOS005266642, CCG-205212, DB01162, FA28036, NC00689, SDCCGSBI-0051105.P002, [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-tetrahydrofuran-2-yl-methanone, 6,7-bis(methyloxy)-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine, NCGC00016026-04, NCGC00016026-05, NCGC00016026-08, NCGC00016026-11, NCGC00025191-03, AC-11120, LS-14728, NS00008855, C07127, D08569, EN300-119614, G77833, L000692, Q280786, BRD-A22256192-003-03-7, BRD-A22256192-003-14-4, BRD-A22256192-003-22-7, BRD-A22256192-310-02-8, Z1172269406, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine, [4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](oxolan-2-yl)methanone, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)-piperazine, 6,7-Dimethoxy-2-[4-(tetrahydro-2-furanylcarbonyl)-1-piperazinyl]-4-quinazolinamine #, 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonxyl]piperazine Hydrochloride, 1-(4-amino-6,7-dimethoxyquinazolin-2-yl)-4-[[(2RS)-2,3,4,5-tetrahydrofuran-2-yl]carbonyl]piperazine
Theoretical properties:
molecular_formula: C19H25N5O4
molecular_weight: 387.4 g/mol
exact_mass: 387.19065430 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 8
rotatable_bond_count: 4
heavy_atom_count: 28
topological_polar_surface_area: 103 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
melting_point: 271-274
solubility: 1.50e+00 g/L
Descriptions:
pubchem: Terazosin is a member of furans, a member of piperazines, a member of quinazolines and a primary amino compound. It has a role as an antineoplastic agent, an antihypertensive agent and an alpha-adrenergic antagonist.
chembl: TERAZOSIN is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Terazosin, sold under the brand name Hytrin among others, is a medication used to treat symptoms of an enlarged prostate and high blood pressure. For high blood pressure, it is a less preferred option. It is taken by mouth.
Common side effects include dizziness, headache, feeling tired, swelling, nausea, and low blood pressure with standing. Severe side effects may include priapism and low blood pressure. Prostate cancer should be ruled out before starting treatment. It is an alpha-1 blocker and works by relaxing blood vessels and the opening of the bladder.
Terazosin was patented in 1975 and came into medical use in 1985. It is available as a generic medication. In 2023, it was the 217th most commonly prescribed medication in the United States, with more than 1 million prescriptions.