Compound: Perampanel
SMILES: O=c1n(-c2ccccc2)cc(-c3ncccc3)cc1-c4c(C#N)cccc4
InChIKey: PRMWGUBFXWROHD-UHFFFAOYSA-N
Synonyms: Perampanel, 380917-97-5, Fycompa, E2007, ER-155055-90, E-2007, perampanelum, E 2007, 3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one, 2-(2-oxo-1-phenyl-5-pyridin-2-ylpyridin-3-yl)benzonitrile, CHEBI:71013, H821664NPK, Benzonitrile, 2-(1',6'-dihydro-6'-oxo-1'-phenyl[2,3'-bipyridin]-5'-yl)-, DTXSID80191501, 2-(6'-oxo-1'-phenyl-1',6'-dihydro-2,3'-bipyridin-5'-yl)benzonitrile, Benzonitrile, 2-(1',6'-dihydro-6'-oxo-1'-phenyl(2,3'-bipyridin)-5'-yl)-, RefChem:58336, DTXCID50113992, N03AX22, Fycompa (TN), 3-(2-Cyanophenyl)-1-phenyl-5-(2-pyridyl)-1,2-dihydropyridin-2-one, 2-(6'-Oxo-1'-Phenyl[1',6'-Dihydro[2,3'-Bipyridine]]-5'-Yl)benzonitrile, Perampanel [USAN:INN], UNII-H821664NPK, 6ZP, Perampanel(E2007, Perampanel(E2007?, PERAMPANEL [MI], PERAMPANEL [INN], Perampanel (JAN/USAN), PERAMPANEL [USAN], PERAMPANEL [VANDF], PERAMPANEL [WHO-DD], orb181081, SCHEMBL194370, GTPL7050, CHEMBL1214124, PERAMPANEL [ORANGE BOOK], SCHEMBL29354621, SCHEMBL29718723, PRMWGUBFXWROHD-UHFFFAOYSA-N, 5'-(2-cyanophenyl)-1'-phenyl-2,3'-bipyridinyl-6'(1'H)-one, EX-A2128, BDBM50184410, AKOS016340421, CH-0056, CS-1160, DB08883, FP65127, SB16816, NCGC00378863-02, AC-27375, HY-14745, AE4 - Newer Anti-epileptic drug mixtures 4, NS00004827, D08964, Q868658, BRD-K41438959-001-01-7, 2-[2-oxo-1-phenyl-5-(2-pyridyl)-3-pyridyl]benzonitrile, 2-(1',6'-Dihydro-6'-oxo-1'-phenyl[2,3'-bipyridin]-5'-yl)benzonitrile, 2-(6'-Oxo-1'-phenyl-1',6'-dihydro[2,3'-bipyridin]-5'-yl)benzonitrile, 1174302-51-2
Theoretical properties:
molecular_formula: C23H15N3O
molecular_weight: 349.4 g/mol
exact_mass: 349.121512110 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 3
rotatable_bond_count: 3
heavy_atom_count: 27
topological_polar_surface_area: 57 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
solubility: Practically insoluble in water.
Descriptions:
{"pubchem": "Perampanel is a member of the class of bipyridines that is 2,3'-bipyridin-6'-one substituted at positions 1' and 5' by phenyl and 2-cyanophenyl groups respectively. Used as an adjunctive therapy for the treatment of partial-onset seizures in patients with epilepsy. It has a role as an anticonvulsant and an AMPA receptor antagonist. It is a nitrile, a pyridone and a member of bipyridines. It is functionally related to a benzonitrile.", "chebi": "A member of the class of bipyridines that is 2,3'-bipyridin-6'-one substituted at positions 1' and 5' by phenyl and 2-cyanophenyl groups respectively. Used as an adjunctive therapy for the treatment of partial-onset seizures in patients with epilepsy.", "chembl": "PERAMPANEL is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.", "wikipedia": "Perampanel, sold under the brand name Fycompa, is an anti-epileptic medication developed by Eisai that is used in addition to other medications to treat partial seizures and generalized tonic\u2013clonic seizures. \nPerampanel is a non-competitive AMPA glutamate receptor antagonist. It is taken by mouth.\nPerampanel was approved in 2012, and as of 2016, its optimal role in the treatment of epilepsy relative to other drugs is not clear. It is the first anti-epileptic drug in the class of selective non-competitive antagonist of AMPA receptors.\nThe US prescribing information has a boxed warning that perampanel may cause serious psychiatric and behavioral changes; it may cause homicidal or suicidal thoughts. Other side effects have included dizziness, somnolence, vertigo, aggression, anger, loss of coordination, blurred vision, irritability, and slurred speech. Perampanel reduced the effectiveness of levonorgestrel oral contraceptives by about 40%. Women who may get pregnant should not take it as studies in animals show it may harm a fetus. Perampanel is liable to be abused; very high doses produced euphoria responses similar to ketamine. It is designated as a Schedule III controlled substance by the US Drug Enforcement Administration. Perampanel is authorized as a generic medication."}