Compound: Glaucine
SMILES: O(c1c2-c3c(cc(OC)c(c3)OC)C[C@H]4c2c(CCN4C)cc1OC)C
InChIKey: RUZIUYOSRDWYQF-HNNXBMFYSA-N
Synonyms: Glaucine, 475-81-0, Bromcholitin, (+)-Glaucine, (6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline, NU19306XA7, NSC-34396, (6aS)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo(de,g)quinoline, RefChem:408057, 5,6,6a,7-Tetrahydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo(de,g)quinoline, d-Glaucine, Boldine dimethyl ether, Glauvent, S-(+)-Glaucine, Glaucine fumarate, 1,2,9,10-tetramethoxyaporphine, 1,2,9,10-Tetramethoxy-6a-alpha-aporphine, NSC34396, CHEMBL228082, NSC 34396, (S)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline, Glaucine, d, EINECS 207-501-5, UNII-NU19306XA7, (S)-5,6,6a,7-Tetrahydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo(de,g)quinoline, 4H-Dibenzo(de,g)quinoline, 5,6,6a,7-tetrahydro-1,2,9,10-tetramethoxy-6-methyl-, (S)-, Tusidil (TN), Boldine dimethylether, Glaucine (Standard), GLAUCINE [MI], GLAUCINE,(D), GLAUCINE [MART.], O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396, 6aalpha-Aporphine, 1,2,9,10-tetramethoxy-, GLAUCINE [WHO-DD], (S)-5,6,6a7-Tetrahydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo(de,g)quinoline, Glaucine; S-(+)-Glaucine, SCHEMBL146441, 6a-alpha-APORPHINE, 1,2,9,10-TETRAMETHOXY-, CHEBI:5373, orb1301260, DTXSID8031100, SCHEMBL29735463, SCHEMBL30213021, HY-N3945R, GLXC-07969, HY-N3945, BDBM50197829, MSK159501, AKOS000276780, EBC-616585, FG65865, MD-0233, DA-73744, Glaucined-Glaucine; Bromcholitin; Glauvent, 6a.alpha.-Aporphine,2,9,10-tetramethoxy-, (s)-(+)-1,2,9,10-tetramethoxyaporphine, CS-0024496, C09446, D08014, E87122, Q2398298, (6aS,11aM)-1,2,9,10-tetramethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline, 4H-Dibenzo[de, 5,6,6a,7-tetrahydro-1,2,9,10-tetramethoxy-6-methyl-, (S)-, (6AS)-5,6,6A,7-TETRAHYDRO-1,2,9,10-TETRAMETHOXY-6-METHYL-4H-DIBENZO(DE,G)QUINOLINE, (9S)-4,5,15,16-tetramethoxy-10-methyl-10-azatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(16),2,4,6,13(17),14-hexaene, 08V
Theoretical properties:
molecular_formula: C21H25NO4
molecular_weight: 355.4 g/mol
exact_mass: 355.17835828 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 5
rotatable_bond_count: 4
heavy_atom_count: 26
topological_polar_surface_area: 40.2 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: (S)-glaucine is an aporphine alkaloid that is (S)-1,2,9,10-tetrahydroxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline in which the four phenolic hydrogens have been replaced by methyl groups. It has a role as an antibacterial agent, an antineoplastic agent, a platelet aggregation inhibitor, an antitussive, a muscle relaxant, a NF-kappaB inhibitor, a plant metabolite and a rat metabolite. It is an aporphine alkaloid, an organic heterotetracyclic compound, a polyether and a tertiary amino compound. It is a conjugate base of a (S)-glaucine(1+).
chebi: An  aporphine alkaloid that is (<i>S</i>)-1,2,9,10-tetrahydroxy-6-methyl-5,6,6a,7-tetrahydro-4<em>H</em>-dibenzo[<em>de,g</em>]quinoline in which the four phenolic hydrogens have been replaced by methyl groups.
chembl: GLAUCINE is a small molecule listed in the ChEMBL database but has not progressed to an approved clinical phase.
wikipedia: Glaucine, also known as 1,2,9,10-tetramethoxyaporphine and sold under the brand names Glauvent and Tusidil among others, is an aporphine alkaloid, antitussive (cough suppressant), and hallucinogen. It is found in several different plant species in the family Papaveraceae, such as Glaucium flavum, Glaucium oxylobum, and Corydalis yanhusuo, and in other plants such as Croton lechleri in the family Euphorbiaceae. Glaucine was first described following isolation from Glaucium flavum in 1839 and its chemical structure became known in 1911.