Compound: hexylresorcinol
SMILES: Oc1c(ccc(c1)O)CCCCCC
InChIKey: WFJIVOKAWHGMBH-UHFFFAOYSA-N
Synonyms: hexylresorcinol, 4-Hexylresorcinol, 136-77-6, 4-hexylbenzene-1,3-diol, 4-Hexyl-1,3-benzenediol, 4-n-Hexylresorcinol, Antascarin, Ascaricid, Ascarinol, Caprokol, Oxana, p-Hexylresorcinol, Crystoids, Adrover, Hidesol, Prensol, 1,3-Benzenediol, 4-hexyl-, 4-Hexylresorcine, Gelovermin, 4-Hexyl-1,3-dihydroxybenzene, Hexylresorcin, Ascaryl, Cystoids anthelmintic, 4-(1-Hexyl)resorcinol, Worm-agen, 1,3-Dihydroxy-4-hexylbenzene, Resorcinol, 4-hexyl-, Hexylresorzin, Mycoderm, Hexylresorcinolum, 1,3-Dihydroxy-4-n-hexylbenzene, NCI-C55787, EverFresh, S.T. 37, DTXSID1020699, ST 37, R9QTB5E82N, INS NO.586, INS-586, NSC1570, 1-(2',4'-Dihydroxyphenyl)hexane, DTXCID10699, E-586, 4 Hexylresorcinol, Myxcin-C, RefChem:55300, MUCINEX INSTASOOTHE, S.T.37, terrasil First Aid Antiseptic Wound and Burn Care, terrasil First Aid Antiseptic Wound and Burn Care Kit, MUCINEX INSTASOOTHE SORE THROAT PLUS PAIN RELIEF, MUCINEX INSTASOOTHE SORE THROAT PLUS SOOTHING COMFORT, 205-257-4, Sucrets, MFCD00002284, ST-37, 4-hexyl resorcinol, NSC 1570, hexyl resorcinol, CHEMBL443605, NCGC00091208-04, Hexylresorcin [German], Kopnol, CAS-136-77-6, CCRIS 888, HSDB 566, EINECS 205-257-4, UNII-R9QTB5E82N, BRN 2048312, AI3-08055, Hexylresorcinol [USP:INN:BAN], Hexylresorcinol CRS, 4-Hexyl-benzenediol, Hexylresorcinol (USP), Spectrum_000869, 1, 4-hexyl-, 4-Hexylresorcinol, 8CI, Spectrum2_000989, Spectrum3_000451, Spectrum4_000001, Spectrum5_000794, 4-Hexylresorcinol, 98%, Hexylresorcinol (Standard), WLN: QR CQ D6, Hexylresorcinol, BAN, USAN, SCHEMBL29107, BSPBio_002122, KBioGR_000341, KBioSS_001349, 4-06-00-06048 (Beilstein Handbook Reference), MLS002152930, DivK1c_000094, HEXYLRESORCINOL [HSDB], SPECTRUM1500330, SPBio_001057, orb1310731, orb3025474, SCHEMBL8848639, 4-HEXYLRESORCINOL [MI], HEXYLRESORCINOL [MART.], 1-(2,4-Dihydroxyphenyl)hexane, 4-Hexyl-1,3-dihydroxy benzene, 4-HEXYLRESORCINOL [FCC], HEXYLRESORCINOL [USP-RS], HEXYLRESORCINOL [WHO-DD], SCHEMBL29373062, BCBcMAP01_000093, CHEBI:93749, HMS500E16, HY-B0986R, KBio1_000094, KBio2_001349, KBio2_003917, KBio2_006485, KBio3_001342, MSK2319, NINDS_000094, 1, 3-Dihydroxy-4-n-hexylbenzene, HMS1920D09, HMS2091J15, HMS3885J08, HMS5083B15, Pharmakon1600-01500330, benzene, 4-hexyl-1,3-dihydroxy-, HY-B0986, NSC-1570, Tox21_111102, Tox21_202263, Tox21_300357, BBL023042, BDBM50292636, CCG-40207, EBC-03468, HEXYLRESORCINOL [EP IMPURITY], NSC757056, s4571, SBB056777, STL008005, HEXYLRESORCINOL [EP MONOGRAPH], 4-Hexylresorcinol, analytical standard, AKOS005683587, Tox21_111102_1, CS-4477, DB11254, FH44835, HEXYLRESORCINOL [USP MONOGRAPH], NSC-757056, BENZENE,1,3-DIHYDROXY,4-HEXYL, IDI1_000094, QTL1_000043, SMP1_000009, NCGC00091208-01, NCGC00091208-02, NCGC00091208-03, NCGC00091208-05, NCGC00091208-06, NCGC00091208-07, NCGC00091208-09, NCGC00091208-11, NCGC00254302-01, NCGC00259812-01, AC-12698, AC-31726, AS-40438, DA-70096, NCI60_001129, SMR000112060, ST092340, SY057042, Hexylresorcinol for system suitability CRS, SBI-0051404.P003, H0139, NS00009746, EN300-77684, D04441, AB00052011_05, F236559, Q229969, SR-05000002054, SR-05000002054-1, BRD-K99946902-001-02-6, BRD-K99946902-001-07-5, Z1197943321, Hexylresorcinol, European Pharmacopoeia (EP) Reference Standard, Hexylresorcinol, United States Pharmacopeia (USP) Reference Standard, Hexylresorcinol for system suitability, EuropePharmacopoeia (EP) Reference Standard, InChI=1/C12H18O2/c1-2-3-4-5-6-10-7-8-11(13)9-12(10)14/h7-9,13-14H,2-6H2,1H
Theoretical properties:
molecular_formula: C12H18O2
molecular_weight: 194.27 g/mol
exact_mass: 194.130679813 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 2
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 5
heavy_atom_count: 14
topological_polar_surface_area: 40.5 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
physical_state: Pale yellow, heavy liq becoming solid on standing at room temp; needles from benzene or petroleum ether
color: Pale yellow, heavy liq becoming solid on standing at room temp; needles from benzene or petroleum ether
odor: Pungent odor
boiling_point: 631 °F at 760 mmHg (NTP, 1992)
melting_point: 154 to 156 °F (NTP, 1992)
solubility: less than 1 mg/mL at 73 °F (NTP, 1992)
vapor_pressure: 0.00000845 [mmHg]
Descriptions:
pubchem: 4-hexylbenzene-1,3-diol is a member of resorcinols.
chembl: HEXYLRESORCINOL is a small molecule listed in the ChEMBL database and has reached clinical trial phase -1.0.
wikipedia: 4-Hexylresorcinol is an organic compound with local anaesthetic, antiseptic, and anthelmintic properties.
As an antiseptic, it is marketed as S.T.37 by Numark Laboratories, Inc. (in a 0.1% solution) for oral pain relief and as a topical antiseptic. It is available for use topically on small skin infections or as an ingredient in throat lozenges. 
As an anthelmintic, 4-hexylresorcinol was sold under the brand Crystoids.
Sytheon Ltd., USA markets 4-hexylresorcinol (trade named Synovea HR). 
Johnson & Johnson uses 4-hexylresorcinol in its Neutrogena, Aveeno, and RoC skincare products as an anti-aging cream. 4-Hexylresorcinol has been used commercially by many cosmetic and personal care companies, such as Mary Kay, Clarins, Unilever, Murad, Facetheory, Arbonne, and many small and large companies. 
A study published in Chemical Research in Toxicology  shows that 4-hexylresorcinol used as a food additive (E-586) exhibits some estrogenic activity, i.e. resembles action of the female sex hormone estrogen. However, a recent study published in Applied Sciences  shows that 4-hexylresorcinol did not change the expression of estrogen receptor-α, -β, or p-ERK1/2 in MCF-7 cells. In an ovariectomized animal model, the 4HR group showed similar levels of ERα, ERβ, and prolactin expression in the pituitary gland compared to the solvent only group, while the estradiol group showed higher levels. Serum prolactin levels were similar between the 4HR and solvent only groups.
In one study, 4-hexylresorcinol increased the shelf life of shrimp by reducing melanosis (black spots).
In mice with cancer, 4-hexylresorcinol inhibited NF-κB and extended their survival rate.