Compound: NEDOCROMIL
SMILES: O=c1c2c(oc(c1)C(=O)O)c(c3n(c(C(=O)O)cc(c3c2)=O)CC)CCC
InChIKey: RQTOOFIXOKYGAN-UHFFFAOYSA-N
Synonyms: NEDOCROMIL, 69049-73-6, Nedocromilo, Nedocromilum, FPL 59002, FPL-59002, 9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano(3,2-g)quinoline-2,8-dicarboxylic acid, DTXSID7023356, 0B535E0BN0, 9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano(3,2-g)chinolin-2,8-dicarbonsaeure, 9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid, CHEBI:7492, DTXCID803356, Tilavist, 4H-Pyrano(3,2-g)quinoline-2,8-dicarboxylic acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-, 9-ethyl-4,6-dioxo-10-propyl-4H,6H,9H-chromeno[7,6-b]pyridine-2,8-dicarboxylic acid, FPL59002, Nedocromil, Disodium Salt, Tilaire, Irtan, Tilad, 9-ethyl-4,6-dioxo-10-propylpyrano(5,6-g)quinoline-2,8-dicarboxylic acid, 9-ethyl-4,6-dioxo-10-propylpyrano[5,6-g]quinoline-2,8-dicarboxylic acid, nedocromil calicum, 9-ethyl-4,6-dioxo-10-propyl-4H,6H,9H-chromeno(7,6-b)pyridine-2,8-dicarboxylic acid, Nedocromil, Calcium Salt (1:1), Sodium, Nedocromil, Calcium, Nedocromil, RefChem:57533, R01AC07, R03BC03, S01GX04, 9-ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid, C19H17NO7, MFCD00864606, NCGC00182073-02, Nedocromilum [Latin], Nedocromilo [Spanish], CAS-69049-73-6, Nedocromil [USAN:INN:BAN], UNII-0B535E0BN0, Nedocromil (Standard), NEDOCROMIL [MI], NEDOCROMIL [INN], Nedocromil (USAN/INN), NEDOCROMIL [USAN], NEDOCROMIL [VANDF], CHEMBL746, SCHEMBL4611, NEDOCROMIL [WHO-DD], BIDD:GT0716, GTPL7607, orb1307974, Nedocromil, >=98% (HPLC), SCHEMBL29406688, EX-A098, GLXC-07259, Tox21_113148, EBC-26832, HY-13448R, 9-ethyl-4,6-dioxo-10-propyl-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid, 9-ethyl-4,6-dioxo-10-propylpyrano[3,2-g]quinoline-2,8-dicarboxylic acid, AKOS016014051, Tox21_113148_1, DB00716, NCGC00182073-03, NCGC00182073-07, AC-30178, AS-56153, HY-13448, DB-055217, NS00009611, C07255, D05129, EN300-19765926, L001326, Q416706, SR-01000944506, SR-01000944506-1, BRD-K64716392-001-01-3, BRD-K64716392-001-02-1, BRD-K64716392-001-03-9
Theoretical properties:
molecular_formula: C19H17NO7
molecular_weight: 371.3 g/mol
exact_mass: 371.10050188 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 2
hydrogen_bond_acceptor_count: 8
rotatable_bond_count: 5
heavy_atom_count: 27
topological_polar_surface_area: 121 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Nedocromil is an organic heterotricyclic compound and a dicarboxylic acid. It has a role as a non-steroidal anti-inflammatory drug, an anti-asthmatic drug and an anti-allergic agent. It is a conjugate acid of a nedocromil(2-).
chembl: NEDOCROMIL is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Nedocromil sodium is a medication considered a mast cell stabilizer which acts to prevent wheezing, shortness of breath, and other breathing problems caused by asthma. It is administered by an inhaler under the brand name Tilade, and as an eye drop under the brand name Alocril.  The effects of nedocromil versus asthma are gradual rather than fast-acting and it is not indicated for acute respiratory distress compared to fast acting bronchodilators like albuterol or other well-known inhaler medications. Liquid preparations of nedocromil are available in the UK under the name Rapitil for use for allergic eye reactions. Nedocromil sodium has been shown to be effective in alleviating symptoms of allergic conjunctivitis. 
Nedocromil is classified as a benzopyrone.  Nedocromil acts as a mast cell stabilizer, inhibits the degranulation of mast cells, prevents release of histamine and tryptase, so preventing the synthesis of prostaglandins and leukotrienes. US Production of inhaled nedocromil ceased in April 2008 because it used CFCs as propellant.