Compound: ACETORPHINE
SMILES: O=C(Oc1c2O[C@H]3[C@@]4(OC)C=C[C@@]5([C@]63c2c(C[C@H]5N(C)CC6)cc1)C[C@@H]4[C@](O)(CCC)C)C
InChIKey: LFYBMMHFJIAKFE-PMEKXCSPSA-N
Synonyms: ACETORPHINE, Acetorfina, Acetorphinum, 25333-77-1, ACETYLPROPYLORVINOL, Acetorphine [INN:BAN], Acetorfina [INN-Spanish], Acetorphinum [INN-Latin], 7.alpha.-etorphine 3-acetate, IDS-NA-001, 2OGQ81529L, IDS-NA-001(SECT.3), ACETORPHINE [INN], 7alpha-etorphine 3-acetate, BRN 4947728, DTXSID60905123, Acetorphine (INN), Acetorfina (INN-Spanish), Acetorphinum (INN-Latin), 6,7,8,14-Tetrahydro-7alpha-(1-hydroxy-1-methylbutyl)-6,14-endo-ethenooripavine 3-acetate, 4,5alpha-Epoxy-7alpha-(1-hydroxy-1-methylbutyl)-6-methoxy-17-methyl-6,14-endo-ethenomorphinan-3-yl acetat, 6,14-endo-Ethenotetrahydrooripavine, 7-alpha-(R)-(1-hydroxy-1-methylbutyl)-, 3-acetate, 6,14-Ethenomorphinan-7-methanol, 3-(acetyloxy)-alpha,17-dimethyl-4,5-epoxy-6-methoxy-alpha-propyl-, (5-alpha,7-alpha(R))-, 6,7,8,14-TETRAHYDRO-7.ALPHA.-(1-HYDROXY-1-METHYLBUTYL)-6,14-ENDO-ETHENOORIPAVINE 3-ACETATE, (1R,2R,6S,14R,15R,19R)-19-((2R)-2-hydroxypentan-2-yl)-15-methoxy-3-methyl-13-oxa-3-azahexacyclo(13.2.2.12,?.01,?.0?,1?.0?,12)icosa-7,9,11,16-tetraen-11-yl acetate, (1R,2R,6S,14R,15R,19R)-19-[(2R)-2-hydroxypentan-2-yl]-15-methoxy-3-methyl-13-oxa-3-azahexacyclo[13.2.2.12,?.01,?.0?,1?.0?,12]icosa-7,9,11,16-tetraen-11-yl acetate, RefChem:552430, DTXCID701334229, 6,14-endo-Ethenotetrahydrooripavine, 7-alpha-(R)-(1-hydroxy-1-methylbutyl)-, 3-acetate (8CI), UNII-2OGQ81529L, SCHEMBL518296, SCHEMBL518297, DEA No. 9319, CHEMBL3989451, DB01469, NS00068009, D12700, Q1065083, 7-[(2R)-2-Hydroxypentan-2-yl]-6-methoxy-17-methyl-5alpha,7alpha-4,5-epoxy-6,14-ethenomorphinan-3-yl acetate, Acetorphine; 6,14-Ethenomorphinan-7-methanol, 3-(acetyloxy)-4,5-epoxy-6-methoxy-a,17-dimethyl-a-propyl-, (aR,5a,7a)-; 6,14-Ethenomorphinan-7-methanol, 3-(acetyloxy)-4,5-epoxy-6-methoxy-a,17-dimethyl-a-propyl-, [5a,7a(R)]-; 6,14-endo-Ethenotetrahydrooripavine, 7a-(R)-(
Theoretical properties:
molecular_formula: C27H35NO5
molecular_weight: 453.6 g/mol
exact_mass: 453.25152322 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 6
rotatable_bond_count: 6
heavy_atom_count: 33
topological_polar_surface_area: 68.2 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
chembl: ACETORPHINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 2.0.
wikipedia: Acetorphine is a potent opioid analgesic, up to 8700 times stronger than morphine by weight. It is a derivative of the more well-known opioid etorphine, which is used as a very potent veterinary painkiller and anesthetic medication, primarily for the sedation of large animals such as elephants, giraffes and rhinos.
Acetorphine was developed in 1966 by the Reckitt research group that developed etorphine. Acetorphine was developed for the same purpose as etorphine itself, namely as a strong tranquilizer for use in immobilizing large animals in veterinary medicine. Despite showing some advantages over etorphine, for instance producing less toxic side effects in giraffes, acetorphine was never widely adopted for veterinary use, and etorphine (along with other tranquilizers such as carfentanil and azaperone) remains the drug of choice in this application.