Compound: Mexiletine
SMILES: O(c1c(cccc1C)C)CC(N)C
InChIKey: VLPIATFUUWWMKC-UHFFFAOYSA-N
Synonyms: Mexiletine, 31828-71-4, 1-(2,6-dimethylphenoxy)propan-2-amine, 1-(2,6-Dimethylphenoxy)-2-propanamine, Mexiletina, Mexiletinum, dl-mexiletine, 2-Propanamine, 1-(2,6-dimethylphenoxy)-, (RS)-Mexiletine, 1-Methyl-2-(2,6-xylyloxy)ethylamine, 2-(2-aminopropoxy)-1,3-dimethylbenzene, ETHYLAMINE, 1-METHYL-2-(2,6-XYLYLOXY)-, 1-(2',6'-Dimethylphenoxy)-2-aminopropane, 1-methyl-2-(2,6-xylyloxy)ethanamine, 1U511HHV4Z, (2RS)-1-(2,6-dimethylphenoxy)-2-aminopropane, CHEBI:6916, DTXSID8048446, (+-)-1-(2,6-dimethylphenoxy)propan-2-amine, Mexityl, mexiletin hydrochloride, Novo Mexiletine, Mexitil PL, RefChem:56491, DTXCID8028420, C01BB02, 250-825-7, Mexitil, Mexiletinum [INN-Latin], Mexiletina [INN-Spanish], 1-(2,6-Dimethylphenoxy)-2-aminopropane, Mexiletine (INN), CHEMBL558, Mexilitine, MFCD00792471, 2-Amino-1-(2,6-dimethylphenoxy)propane, MEXILETINE [INN], Mexiletine [INN:BAN], (+/-)-Mexiletine, NCGC00015659-06, EINECS 250-825-7, BRN 2092205, UNII-1U511HHV4Z, Mexitil (Salt/Mix), 1-(2,4-Dimethylphenoxy)-2-propanamine, Spectrum_001602, MEXILETINE [MI], Prestwick0_000241, Prestwick1_000241, Prestwick2_000241, Prestwick3_000241, Spectrum3_000727, Spectrum4_000795, Spectrum5_001279, MEXILETINE [VANDF], MEXILETINE [WHO-DD], Lopac0_000784, SCHEMBL16081, BSPBio_000022, BSPBio_002254, KBioGR_001270, KBioSS_002082, DivK1c_000834, SPBio_002241, BPBio1_000026, GTPL2629, orb1705062, KBio1_000834, KBio2_002082, KBio2_004650, KBio2_007218, KBio3_001474, NINDS_000834, Mexiletine hydrochloride (Salt/Mix), BDBM50117271, EBC-04158, SBB070242, AKOS015890265, CCG-204869, DB00379, SB45974, SB45976, SDCCGSBI-0050762.P004, 1-(2,6-dimethylphenoxy)prop-2-ylamine, IDI1_000834, NCGC00015659-02, NCGC00015659-03, NCGC00015659-04, NCGC00015659-05, NCGC00015659-07, NCGC00015659-08, NCGC00015659-09, NCGC00015659-10, NCGC00015659-11, NCGC00015659-13, NCGC00015659-23, NCGC00162253-01, NCGC00162253-02, 1-(2,6-dimethylphenoxy)-2-propanolamine, FM153231, SBI-0050762.P003, 2-(2,6-dimethylphenoxy)-1-methylethylamine, AB00053683, CS-0068642, NS00008331, 2-(2,6-dimethylphenoxy)-1-methyl-ethylamine, EN300-54300, 2-(2,6-Dimethyl-phenoxy)-1-methyl-ethylamine, C07220, D08215, H40619, (+/-)-1-(2,6-dimethylphenoxy)propan-2-amine, AB00053683_10, AB00053683_11, Q420377, BRD-A64092382-003-04-3, BRD-A64092382-003-09-2, BRD-A64092382-003-16-7, BRD-A64092382-003-17-5, BRD-A64092382-003-18-3, (+/-)-2-AMINO-1-(2',6'-DIMETHYLPHENOXY)PROPANE, (2-((2,6-DIMETHYLPHENYL)OXY)-1-METHYLETHYL)AMINE, 2-(2,6-Dimethyl-phenoxy)-1-methyl-ethylamine(Mexiletine)
Theoretical properties:
molecular_formula: C11H17NO
molecular_weight: 179.26 g/mol
exact_mass: 179.131014166 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 3
heavy_atom_count: 13
topological_polar_surface_area: 35.3 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
melting_point: 203-205 °C
Descriptions:
pubchem: Mexiletine is an aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol. It has a role as an anti-arrhythmia drug. It is an aromatic ether and a primary amino compound.
chebi: An aromatic ether which is 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
chembl: MEXILETINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Mexiletine (INN; sold under the brand names Mexitil and Namuscla) is a medication used to treat abnormal heart rhythms, chronic pain, and some causes of muscle stiffness. Common side effects include abdominal pain, chest discomfort, drowsiness, headache, and nausea. It works as a non-selective voltage-gated sodium channel blocker and belongs to the Class IB group of anti-arrhythmic medications.