Compound: TPEN
SMILES: n1c(cccc1)CN(Cc2ncccc2)CCN(Cc3ncccc3)Cc4ncccc4
InChIKey: CVRXLMUYFMERMJ-UHFFFAOYSA-N
Synonyms: TPEN, 16858-02-9, N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine, TPEDA, 1,2-Ethanediamine, N,N,N',N'-tetrakis(2-pyridinylmethyl)-, R9PTU1U29I, DTXSID50168583, CHEBI:88217, 1,2-Ethanediamine, N,N,N',N'-tetrakis(2-pyridinylmethyl)-, (OC-6-11)-, RefChem:822045, DTXCID9091074, 605-520-7, N1,N1,N2,N2-Tetrakis(pyridin-2-ylmethyl)ethane-1,2-diamine, MFCD00036918, N,N,N',N'-tetrakis(2-pyridylmethyl)ethane-1,2-diamine, N,N,N',N'-Tetrakis(2-pyridinylmethyl)-1,2-ethanediamine, N,N,N',N'-Tetrakis(2-pyridylmethyl)-1,2-ethylenediamine, N,N,N',N'-tetrakis(pyridin-2-ylmethyl)ethane-1,2-diamine, C26H28N6, N,N,N inverted exclamation mark ,N inverted exclamation mark -Tetrakis(2-pyridylmethyl)ethylenediamine, UNII-R9PTU1U29I, CVRXLMUYFMERMJ-UHFFFAOYSA-N, N,N,N',N'-Tetrakis(2-pyridyl-methyl)ethylenediamine, TPEN?, TPEN [MI], BSPBio_001186, KBioGR_000526, KBioSS_000526, SCHEMBL231092, orb1303522, CHEMBL1472575, SCHEMBL29427509, KBio2_000526, KBio2_003094, KBio2_005662, KBio3_000951, KBio3_000952, BDBM367675, Bio1_000452, Bio1_000941, Bio1_001430, Bio2_000433, Bio2_000913, GLXC-04670, HMS1362L07, HMS1792L07, HMS1990L07, HMS3403L07, HMS6018I21, EX-A1234, US10227327, TPEN, s6962, (2-{bis[(pyridin-2-yl)methyl]amino}ethyl)bis[(pyridin-2-yl)methyl]amine, AKOS015903640, CS-6042, FT28156, IDI1_002188, NCGC00163483-01, NCGC00163483-02, AC-27933, AS-70319, DA-58681, SY052905, HY-100202, TPEN - CAS 16858-02-9, T1487, F826837, BRD-K10385824-001-02-8, N,N,N',N'-Tetrakis (2-pyridylmethyl)-ethylenediamine, Q27160135, ethylenediamine, N,N,N',N'-tetrakis-(2-pyridylmethyl)-, N,N,N',N'-Tetrakis(2-pyridylmethyl)-1,2-diaminoethane, N,N,N',N'-Tetrakis-pyridin-2-ylmethyl-ethane-1,2-diamine, 1,2-Ethanediamine, N^1,N^1,N^2,N^2-tetrakis(2-pyridinylmethyl)-, N(1),N(1),N(2),N(2)-tetrakis[(pyridin-2-yl)methyl]ethane-1,2-diamine, N~1~,N~1~,N~2~,N~2~-Tetrakis[(pyridin-2-yl)methyl]ethane-1,2-diamine
Theoretical properties:
molecular_formula: C26H28N6
molecular_weight: 424.5 g/mol
exact_mass: 424.23754492 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 6
rotatable_bond_count: 11
heavy_atom_count: 32
topological_polar_surface_area: 58 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine is an N-substituted diamine that is ethylenediamine in which the four amino hydrogens are replaced by 2-pyridylmethyl groups. It has a role as a copper chelator, a chelator and an apoptosis inducer. It is a member of pyridines, a N-substituted diamine and a tertiary amino compound. It is functionally related to an ethylenediamine.
chebi: An <em>N</em>-substituted diamine that is ethylenediamine in which the four amino hydrogens are replaced by 2-pyridylmethyl groups.
chembl: Unnamed Compound is a small molecule listed in the ChEMBL database but has not progressed to an approved clinical phase.
wikipedia: TPEN (N,N,N′,N′-tetrakis(2-pyridinylmethyl)-1,2-ethanediamine) is an intracellular membrane-permeable ion chelator. TPEN has a high affinity for many transition metals and should not be considered specific or selective for a particular ion. Chelators can be used in chelation therapy to remove toxic metals in the body. TPEN is a chelator that has a high affinity for zinc. For example, one study showed that TPEN is a stronger chelator compared to other chelators like pentetic acid (DTPA) when high levels of zinc are present (15 μM). When low levels of zinc were present however (0, 3, 6, 9 and 12 μM zinc), there was no significant difference. TPEN is a hexadentate ligand which also forms complexes with other soft metal ions such as Cd2+.