Compound: Bemotrizinol
SMILES: O(c1cc(O)c(-c2nc(nc(n2)-c3ccc(OC)cc3)-c4c(O)cc(OCC(CCCC)CC)cc4)cc1)CC(CCCC)CC
InChIKey: XVAMCHGMPYWHNL-UHFFFAOYSA-N
Synonyms: Bemotrizinol, 187393-00-6, Tinosorb S, Bis-ethylhexyloxyphenol Methoxyphenyl Triazine, BEMT, FAT 70'884, PWZ1720CBH, NSC-759870, 2,2'-(6-(4-Methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(5-((2-ethylhexyl)oxy)phenol), FAT-70884, 5-[(2-ethylhexyl)oxy]-2-(4-{4-[(2-ethylhexyl)oxy]-2-hydroxyphenyl}-6-(4-methoxyphenyl)-1,3,5-triazin-2-yl)phenol, DTXSID40896984, Phenol, 2,2'-(6-(4-methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(5-((2-ethylhexyl)oxy)-, 2,2'-[6-(4-methoxyphenyl)-1,3,5-triazine-2,4-diyl]bis{5-[(2-ethylhexyl)oxy]phenol}, bemotrizinolum, 5-((2-ethylhexyl)oxy)-2-(4-(4-((2-ethylhexyl)oxy)-2-hydroxyphenyl)-6-(4-methoxyphenyl)-1,3,5-triazin-2-yl)phenol, RefChem:561229, DTXCID701326412, 425-950-7, 933-511-0, Phenol,2,2'-[6-(4-methoxyphenyl)-1,3,5-triazine-2,4-diyl]bis[5-[(2-ethylhexyl)oxy]-, MFCD08435974, CGF 1607, 6,6'-(6-(4-Methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(3-((2-ethylhexyl)oxy)phenol), Bemotrizinol ;CGF 1607, 2,4-bis[4-(2-ethylhexyloxy)-2-hydroxyphenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, Tinosorb S Aqua, Bemotrizinol [USAN], Bemotrizinol [USAN:INN], UNII-PWZ1720CBH, C38H49N3O5, Tinosorb S (TN), Bemotrizinol (Standard), BEMOTRIZINOL [MI], Bemotrizinol (USAN/INN), BEMOTRIZINOL [INN], SCHEMBL77320, BEMOTRIZINOL [MART.], BEMOTRIZINOL [USP-RS], BEMOTRIZINOL [WHO-DD], SCHEMBL649229, orb1298416, orb3139330, CHEMBL2104956, SCHEMBL29350308, SCHEMBL29360093, Bemotrizinol, analytical standard, MSK3427, CHEBI:135857, HMS3264F07, Pharmakon1600-01503863, HY-W099730R, EBC-27398, NSC759870, ZB0626, AKOS030621549, DB11206, HY-W099730, NSC 759870, NCGC00261970-01, 5-(2-ethylhexoxy)-2-[4-[4-(2-ethylhexoxy)-2-hydroxyphenyl]-6-(4-methoxyphenyl)-1,3,5-triazin-2-yl]phenol, AS-73952, FB161854, SY041028, B6145, CS-0152372, NS00077719, D03227, F20693, AB01563045_01, EN300-23553143, F694927, Q4885134, BRD-A92974210-396-01-0, Bemotrizinol, United States Pharmacopeia (USP) Reference Standard, 2,4-Bis[4-(2-ethylhexyloxy)-2-hydroxyphenyl]-6-(4-methoxyphenyl)-1,3,5-triazine (Bemotrizinol), 5-(2-ethylhexoxy)-2-[4-[4-(2-ethylhexoxy)-2-hydroxy-phenyl]-6-(4-methoxyphenyl)-1,3,5-triazin-2-yl]phenol
Theoretical properties:
molecular_formula: C38H49N3O5
molecular_weight: 627.8 g/mol
exact_mass: 627.36722167 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 2
hydrogen_bond_acceptor_count: 8
rotatable_bond_count: 18
heavy_atom_count: 46
topological_polar_surface_area: 107 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
boiling_point: >400
solubility: Insoluble
Descriptions:
pubchem: Bemotrizinol is a member of methoxybenzenes.
chembl: BEMOTRIZINOL is a small molecule listed in the ChEMBL database and has reached clinical trial phase 3.0.
wikipedia: Bemotrizinol (INN, USAN, INCI name bis-ethylhexyloxyphenol methoxyphenyl triazine, BEMT; marketed as Escalol S, Parsol Shield, and Tinosorb S) is an oil-soluble organic compound that is added to sunscreens to absorb UV rays.
Bemotrizinol is a broad-spectrum UV absorber, absorbing both UVB and UVA rays. It has two absorption peaks, 310 and 340 nm. It is highly photostable. Even after 50 MEDs (minimal erythemal doses), 98.4% remains intact. It helps prevent the  photodegradation of other sunscreen actives like avobenzone. Tinosorb S Aqua, recently developed by BASF, is bemotrizinol in a PMMA matrix dispersed in water. This makes it possible to add bemotrizinol to the water phase.
Bemotrizinol has strong synergistic effects on the SPF when formulated with bisoctrizole, ethylhexyl triazone, or iscotrizinol. It is the most effective UV absorber available measured by SPF, based on the maximum concentration permitted by European legislation.
In 2025, the United States Food and Drug Administration proposed to approve bemotrizinol for use in sunscreens. It has been approved in the European Union since 2000 and some other parts of the world, including Australia.
Unlike some other organic sunscreen actives, it shows no estrogenic effects in vitro.