Compound: L-leucine
SMILES: O=C(O)[C@@H](N)CC(C)C
InChIKey: ROHFNLRQFUQHCH-YFKPBYRVSA-N
Synonyms: L-leucine, leucine, 61-90-5, (S)-Leucine, (S)-2-Amino-4-methylpentanoic acid, (2S)-2-amino-4-methylpentanoic acid, Leucin, (S)-2-Amino-4-methylvaleric acid, (S)-(+)-Leucine, L-alpha-Aminoisocaproic acid, LEUCINE, L-, Leucinum, Leucina, FEMA No. 3297, (2S)-alpha-leucine, L-leucin, 2-amino-4-methylvaleric acid, L-(-)-2-Amino-4-methylpentanoic acid, alpha-Aminoisocaproic acid, L-Leuzin, Leucine, l, NSC-46709, (2S)-alpha-2-amino-4-methylvaleric acid, GMW67QNF9C, L-Leu, DTXSID9023203, CHEBI:15603, (2S)-2-amino-4-methylpentanoate, L-Isomer Leucine, CHEBI:25017, NSC9252, L-Leucine High, L-Leucine 7413, RefChem:6453, L-Leucine High 7414, 2-Aminoisobutylacetic acid, DTXCID903203, 200-522-0, (2S)-2-azaniumyl-4-methylpentanoate, H-Leu-OH, leu, L-Norvaline, 4-methyl-, Leucin [German], Leucine (VAN), MFCD00002617, L-(+)-Leucine, Leucine [USAN:INN], Leucinum [INN-Latin], Leucina [INN-Spanish], Leucina [Latin,Spanish], Valeric acid, 2-amino-4-methyl-, (S)-, Pentanoic acid, 2-amino-4-methyl-, (S)-, 2-Amino-4-methylpentanoic acid, (S)-, AI3-08899, 2-Amino-4-methylvaleric acid (L), 2-Amino-4-methylpentanoic acid (L), NSC 46709, Leucine (L-Leucine), L-Leu-OH, CHEMBL291962, L-Leucine, labeled with tritium, Certified Reference Material of L-leucine, 21675-61-6, M03060, L-a-Aminoisocaproic acid, L-Leucine, Non-animal origin, EINECS 200-522-0, UNII-GMW67QNF9C, H-Leu-2-Chlorotrityl Resin, Pentanoic acid, 2-amino-4-methyl-, HSDB 7799, Leucine CRS, LeuOH, 1lan, 1usk, 3h-l-leucine, L-2-Amino-4-methylpentanoic acid, (L)-leucine, .alpha.-Amino-.gamma.-methylvaleric acid, 25322-63-8, (3H)Leucine, H-Leu, L-Leucine, USP, Leucine (USP), L-a-Aminoisocaproate, Lysine Impurity 14, Leucine (H-3), 4-methyl-L-Norvaline, (2S)-2-amino-4-methyl-pentanoic acid, L-Leucine (Standard), H-Leu-OH USP grade, L-Leucine-13C6?, 1f2o, starbld0005460, L-Leucine (JP18), L-alpha-Aminoisocaproate, LEUCINE [VANDF], LEUCINE [HSDB], LEUCINE [USAN], LEUCINE [INN], LEUCINE [II], LEUCINE [MI], L-LEUCINE [FCC], L-LEUCINE [JAN], LEUCINE [MART.], L-LEUCINE [FHFI], LEUCINE [WHO-DD], bmse000042, bmse000920, L-Leucine, AJI92 grade, EC 200-522-0, L-Leucine, 99%, FG, SCHEMBL3889, NCIStruc1_001860, NCIStruc2_000010, iso-C4H9CH(NH2)COOH, L-LEUCINE [USP-RS], LEUCINE [EP MONOGRAPH], 2-Amino-4-methyl-valeric acid, GTPL3312, L-.alpha.-Aminoisocaproic acid, orb1303448, SCHEMBL2692807, SCHEMBL6526967, (S)-2-Amino-4-methylvalerate, LEUCINE [USP MONOGRAPH], Norvaline, 4-methyl-, (L)-, HY-N0486R, (S)-2-Amino-4-methylpentanoate, MSK1411, IS_LEUCINE-5,5,5-D3, Pharmakon1600-01301005, HY-N0486, NCI46709, STR01720, L-Leucine, Vetec(TM), 98.5%, (R-)-2-Amino-4-methylvaleric acid, BDBM50219348, CCG-37658, EBC-14834, NCGC00013565, NSC760100, s3753, (S)-2-Amino-4-methyl-pentanoic acid, 2-Amino-4-methylvaleric acid, (L)-, AKOS010373766, AKOS015841779, CS-W020705, DB00149, FL12677, FL72363, NSC-760100, 2-Amino-4-methylpentanoic acid, (L)-, VALINE IMPURITY C [EP IMPURITY], L-Leucine, tested according to Ph.Eur., NCGC00013565-02, NCGC00096678-01, 71000-80-1, E641, FL180129, SY005863, L-Leucine, BioUltra, >=99.5% (NT), DB-029966, L-Leucine(Discontinued,See C4X-221114), L-Leucine, SAJ special grade, >=99.0%, L-Leucine, reagent grade, >=98% (HPLC), L0029, NS00125065, EN300-52627, L-Leucine, Vetec(TM) reagent grade, >=98%, C00123, D00030, F70226, L-2700, L-Leucine, Cell Culture Reagent (H-L-Leu-OH), Q483745, Q-201312, BRD-K12853841-001-02-2, L-Leucine, certified reference material, TraceCERT(R), LYSINE HYDROCHLORIDE IMPURITY A [EP IMPURITY], 2B9FF792-3CA1-4BEA-BC63-6D4E1A86714E, F8889-8638, Leucine, European Pharmacopoeia (EP) Reference Standard, Z756437526, L-Leucine, United States Pharmacopeia (USP) Reference Standard, L-Leucine, Pharmaceutical Secondary Standard; Certified Reference Material, L-Leucine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, 98.5-101.0%
Theoretical properties:
molecular_formula: C6H13NO2
molecular_weight: 131.17 g/mol
exact_mass: 131.094628657 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 2
hydrogen_bond_acceptor_count: 3
rotatable_bond_count: 3
heavy_atom_count: 9
topological_polar_surface_area: 63.3 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
physical_state: White glistening hexagonal plates from aqueous alcohol
color: White glistening hexagonal plates from aqueous alcohol
boiling_point: Sublimes at 145-148 °C. Decomposes at 293-295 °C (rapid heating, sealed tube)
density: 1.293 g/cu cm at 18 °C
vapor_pressure: 0.00000001 [mmHg]
Descriptions:
{"pubchem": "L-leucine is the L-enantiomer of leucine. It has a role as a mouse metabolite, a Saccharomyces cerevisiae metabolite, a plant metabolite, an Escherichia coli metabolite, a human metabolite and an algal metabolite. It is a L-alpha-amino acid, a leucine, a pyruvate family amino acid and a proteinogenic amino acid. It is a conjugate base of a L-leucinium. It is a conjugate acid of a L-leucinate. It is an enantiomer of a D-leucine. It is a tautomer of a L-leucine zwitterion.", "chebi": "The <small>L</small>-enantiomer of leucine.", "chembl": "LEUCINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 3.0.", "wikipedia": "Leucine or leucin (symbol Leu or L) is an essential amino acid that is used in the biosynthesis of proteins. Leucine is an \u03b1-amino acid, meaning it contains an \u03b1-amino group (which is in the protonated \u2212NH3+ form under biological conditions), an \u03b1-carboxylic acid group (which is in the deprotonated \u2212COO\u2212 form under biological conditions), and a side chain isobutyl group, making it a non-polar aliphatic amino acid. It is essential in humans, meaning the body cannot synthesize it; it must be obtained from the diet. Human dietary sources are foods that contain protein, such as meats, dairy products, soy products, and beans and other legumes. It is encoded by the codons UUA, UUG, CUU, CUC, CUA, and CUG. Leucine is named after the Greek word for 'white': \u03bb\u03b5\u03c5\u03ba\u03cc\u03c2 (leuk\u00f3s 'white'), after its common appearance as a white powder, a property it shares with many other amino acids.\nLike valine and isoleucine, leucine is a branched-chain amino acid. The primary metabolic end products of leucine metabolism are acetyl-CoA and acetoacetate; consequently, it is one of the two exclusively ketogenic amino acids, with lysine being the other. It is the most important ketogenic amino acid in humans.\nLeucine and \u03b2-hydroxy \u03b2-methylbutyric acid, a minor leucine metabolite, exhibit pharmacological activity in humans and have been demonstrated to promote protein biosynthesis via the phosphorylation of the mechanistic target of rapamycin (mTOR).\n\n"}