Compound: HYDROCODONE
SMILES: O=C1[C@@H]2Oc3c(OC)ccc4c3[C@]25[C@H]([C@H](N(C)CC5)C4)CC1
InChIKey: LLPOLZWFYMWNKH-CMKMFDCUSA-N
Synonyms: HYDROCODONE, Dihydrocodeinone, Hydrocodon, Hydrocone, Hydroconum, Bekadid, Multacodin, (-)-Dihydrocodeinone, hidrocodona, Idrocodone, 125-29-1, DICO, Hydrocodonum, 4,5-alpha-Epoxy-3-methoxy-17-methylmorphinan-6-one, 6-Oxo-3-methoxy-N-methyl-4,5-epoxymorphinan, 6YKS4Y3WQ7, NSC-19044, CHEBI:5779, DTXSID8023131, Morphinan-6-one, 4,5alpha-epoxy-3-methoxy-17-methyl-, Morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl-, Morphinan-6-one, 4,5-epoxy-3-methoxy-17-methyl-, (5alpha)-, (4R,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one, Hydrocodeinonebitartrate, (1S,5R,13R,17R)-10-methoxy-4-methyl-12-oxa-4-azapentacyclo(9.6.1.0^(1,13).0^(5,17).0^(7,18))octadeca-7(18),8,10-trien-14-one, (1S,5R,13R,17R)-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-one, (4R,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro(3,2-e)isoquinolin-7-one, (4R,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro(3,2-e)isoquinoline-7-one, (4R,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one, RefChem:5891, DTXCID803131, R05DA03, Hydrocodone Tartrate (1:1), Hydrate (2:5), (1S,5R,13R,17R)-10-methoxy-4-methyl-12-oxa-4-azapentacyclo(9.6.1.01,13.05,17.07,18)octadeca-7(18),8,10-trien-14-one, 204-733-9, Codinovo, Idrocodone [DCIT], Dicodid, Hydrocodonum [INN-Latin], Hidrocodona [INN-Spanish], Codeinone, dihydro-, 4,5alpha-Epoxy-3-methoxy-17-methylmorphinan-6-one, Hydrocodone (INN), HYDROCODONE [INN], NSC 19044, Hydrocodone [INN:BAN], Hydrocodone polistirex, HSDB 3097, NCGC00159317-02, EINECS 204-733-9, 4,5.alpha.-Epoxy-3-methoxy-17-methylmorphinan-6-one, UNII-6YKS4Y3WQ7, BRN 0094193, opioid1, DEA No. 9193, 3-methoxy-17-methyl-4,5alpha-epoxymorphinan-6-one, HYDROCODONE CII, HYDROCODONE-, HYDROCODONE [MI], HYDROCODONE [HSDB], Epitope ID:549283, HYDROCODONE [VANDF], SCHEMBL2987, CHEMBL1457, HYDROCODONE [WHO-DD], 4-27-00-03580 (Beilstein Handbook Reference), Hydrocodone polistirex [USAN], Morphinan-6-one, 4,5-epoxy-3-methoxy-17-methyl-, (5.alpha.)-, GTPL7081, SCHEMBL29392417, Hydrocodone, 1mg/ml in Methanol, HYDROCODONE CII [USP-RS], (5alpha)-17-methyl-3-(methyloxy)-4,5-epoxymorphinan-6-one, Hydrocodone 0.1 mg/ml in Methanol, Hydrocodone 1.0 mg/ml in Methanol, BDBM50386689, Oxycodone hydrochloride, hydrocodone-, Hydrocodone (1.0mg/mL in Methanol), DB00956, NCGC00159317-03, DB-243593, NS00009201, C08024, D08045, Q411441, 17-methyl-4,5alpha-epoxy-3-methoxymorphinan-6-one, 3-Methoxy-17-methyl-5alpha-4,5-epoxymorphinan-6-one, 4,5alpha-epoxy-3-methoxy-17-methyl-morphinan-6-one, Morphinan-6-one,5.alpha.-epoxy-3-methoxy-17-methyl-, OXYCODONE HYDROCHLORIDE IMPURITY E [EP IMPURITY], OXYCODONE HYDROCHLORIDE, HYDROCODONE- [USP IMPURITY], Morphinan-6-one,5-epoxy-3-methoxy-17-methyl-, (5.alpha.)-, (5.ALPHA.)-3-METHOXY-17-METHYL-4,5-EPOXYMORPHINAN-6-ONE, DIHYDROCODEINE HYDROGEN TARTRATE IMPURITY C [EP IMPURITY], WLN: T B6566 B6/CO 4ABBC R BX FV HO PN GHT&&TTJ JO1 P1, 4aH-8,5-bcd]furan-5-(6H)-one, 7,7a,8,9-tetrahydro-3-methoxy-12-methyl-, Dihydrocodeine Hydrogen Tartrate EP Impurity C; Oxycodone Hydrochloride EP Impurity E, (4R,4aR,7aR,12bS)-9-methoxy-3-methyl-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one, 50678-79-0
Theoretical properties:
molecular_formula: C18H21NO3
molecular_weight: 299.4 g/mol
exact_mass: 299.15214353 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 4
rotatable_bond_count: 1
heavy_atom_count: 22
topological_polar_surface_area: 38.8 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
physical_state: Prisms from alcohol
color: Prisms from alcohol
solubility: Soluble in acetone, ethyl acetate, chloroform
flash_point: 9.7 °C (49.5 °F) - closed cup
Descriptions:
{"pubchem": "Hydrocodone is a morphinane-like compound that is a semi-synthetic opioid synthesized from codeine. It has a role as an opioid analgesic, an antitussive and a mu-opioid receptor agonist. It is an organic heteropentacyclic compound and a morphinane-like compound. It derives from a hydride of a morphinan.", "chebi": "A morphinane-like compound that is a semi-synthetic opioid synthesized from codeine.", "chembl": "HYDROCODONE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.", "wikipedia": "Hydrocodone, also known as dihydrocodeinone, is a semi-synthetic opioid used to treat pain and as a cough suppressant. It is taken by mouth. Typically, it is dispensed as the combination acetaminophen/hydrocodone or ibuprofen/hydrocodone for pain severe enough to require an opioid and in combination with homatropine methylbromide to relieve cough. It is also available by itself in a long-acting form sold under the brand name Zohydro ER, among others, to treat severe pain of a prolonged duration. Hydrocodone is a controlled drug: in the United States, it is classified as a Schedule II Controlled Substance.\nCommon side effects include dizziness, sleepiness, nausea, and constipation. Serious side effects may include low blood pressure, seizures, QT prolongation, respiratory depression, and serotonin syndrome. Rapidly decreasing the dose may result in opioid withdrawal. Use during pregnancy or breastfeeding is generally not recommended. Hydrocodone is believed to work by activating opioid receptors, mainly in the brain and spinal cord. Hydrocodone 10 mg is equivalent to about 10 mg of morphine by mouth.\nHydrocodone was patented in 1923, while the long-acting formulation was approved for medical use in the United States in 2013. It is most commonly prescribed in the United States, which consumed 99% of the worldwide supply as of 2010. In 2018, it was the 402nd most commonly prescribed medication in the United States, with more than 400,000 prescriptions. Hydrocodone is a semi-synthetic opioid, converted from codeine or less often from thebaine. Production using genetically engineered yeasts has been developed but is not used commercially."}