Compound: cromolyn
SMILES: O=c1c2c(oc(c1)C(=O)O)cccc2OCC(O)COc3c4c(=O)cc(C(=O)O)oc4ccc3
InChIKey: IMZMKUWMOSJXDT-UHFFFAOYSA-N
Synonyms: cromolyn, Cromoglicic acid, 16110-51-3, Cromoglycic acid, Cromoglicate, Acido cromoglicico, Acide cromoglicique, Acidum cromoglicicum, Cromo-Comod, Y0TK0FS77W, 5-[3-(2-carboxy-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylic acid, R03BC01, 1,3-Bis(2-carboxychromon-5-yloxy)-2-hydroxypropane, DTXSID4022860, CHEBI:59773, 1,3-Di(2-carboxy-4-oxochromen-5-yloxy)propan-2-ol, 5,5'-(2-Hydroxytrimethylenedioxy)bis(4-oxochromene-2-carboxylic acid), 4H-1-Benzopyran-2-carboxylic acid, 5,5'-((2-hydroxytrimethylene)dioxy)bis(4-oxo-, 5-{3-[(2-carboxy-4-oxo-4H-chromen-5-yl)oxy]-2-hydroxypropoxy}-4-oxo-4H-chromene-2-carboxylic acid, 5-(3-((2-Carboxy-4-oxo-4H-chromen-5-yl)oxy)-2-hydroxypropoxy)-4-oxo-4H-chromene-2-carboxylic acid, 5-[3-(2-carboxy-4-oxo-4H-5-chromenyloxy)-2-hydroxypropoxy]-4-oxo-4H-2-chromenecarboxylic acid, 5-(3-(2-carboxy-4-oxochromen-5-yl)oxy-2-hydroxypropoxy)-4-oxochromene-2-carboxylic acid, 5-(3-(2-carboxy-4-oxo-4H-5-chromenyloxy)-2-hydroxypropoxy)-4-oxo-4H-2-chromenecarboxylic acid, RefChem:54897, DTXCID602860, 4H-1-Benzopyran-2-carboxylic acid, 5,5'-((2-hydroxy-1,3-propanediyl)bis(oxy))bis(4-oxo)-, 240-279-8, Cromoglycate, 5,5'-((2-Hydroxypropane-1,3-diyl)bis(oxy))bis(4-oxo-4H-chromene-2-carboxylic acid), Intal, Acide cromoglicique [INN-French], Acido cromoglicico [INN-Spanish], Acidum cromoglicicum [INN-Latin], MFCD00864784, Aararre, Frenasma, Lomudas, Nebulasma, Nasmil, Cromo asma aerosol, Cromoglicic acid (INN), Dinatrium cromoglicicum, CROMOGLICIC ACID [INN], 4H-1-Benzopyran-2-carboxylic acid, 5,5'-((2-hydroxy-1,3-propanediyl)bis(oxy))bis(4-oxo-, 4H-1-Benzopyran-2-carboxylic acid, 5,5'-[(2-hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-, 5,5'-((2-Hydroxypropane-1,3-diyl)bis(oxy))-bis(4-oxo-4H-chromene-2-carboxylic acid), 5,5'-[(2-hydroxypropane-1,3-diyl)bis(oxy)]bis(4-oxo-4H-chromene-2-carboxylic acid), Sodium Chromoglycate, Cromoglicic acid D5, NCGC00021142-02, C23H16O11, UNII-Y0TK0FS77W, Chromoglycate, Chromolyn, Cromoglicic acid [INN:BAN], cromoglicic-acid, HSDB 3308, EINECS 240-279-8, Cromo-Comod (TN), Spectrum_000852, CROMOLYN [HSDB], CROMOLYN [MI], CROMOLYN [VANDF], Prestwick0_000812, Prestwick1_000812, Prestwick2_000812, Prestwick3_000812, Spectrum2_001137, Spectrum3_000367, Spectrum4_000302, Spectrum5_000791, GlyTouCan:G89005SR, SCHEMBL3865, Oprea1_077850, BSPBio_000703, BSPBio_002093, KBioGR_000884, KBioSS_001332, BIDD:GT0397, DivK1c_000857, SPBio_001033, SPBio_002624, BPBio1_000775, CHEMBL428880, GTPL7608, orb1299097, SCHEMBL29352570, SCHEMBL29353205, KBio1_000857, KBio2_001332, KBio2_003900, KBio2_006468, KBio3_001313, CROMOGLICIC ACID [WHO-DD], NINDS_000857, GLXC-07873, G89005SR, HY-B1619, BDBM50440033, EBC-27171, AKOS015961001, DB01003, IDI1_000857, NCGC00021142-01, NCGC00159523-01, AC-12785, BS-51003, FC171543, NCI60_000229, SBI-0051323.P003, CS-0013552, NS00006731, 1,3-bis(2-carboxychromon-5-yloxy)propan-2-ol, C06928, D07753, E78436, 1,3-bis-(2-carboxychromon-5-yloxy)propan-2-ol, EN300-19766015, F863363, Q416427, BRD-K20920669-304-06-7, BRD-K20920669-304-09-1, BRD-K20920669-304-10-9, 4H-1-Benzopyran-2-carboxylic acid, 5, {5'-[(2-hydroxytrimethylene)dioxy]bis(4-oxo-,}, 5,5'-((2-HYDROXYTRIMETHYLENE)DIOXY)BIS(4-OXO-4H-1-BENZOPYRAN-2-CARBOXYLATE), 5,5'-[(2-Hydroxypropane-1,3-diyl)bis(oxy)]bis(4-oxo-4H-1-benzopyran-2-carboxylic acid), 105878-73-7, 2140317-08-2, 4H-1-Benzopyran-2-carboxylic acid, {5,5'-[(2-hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-,}, 4H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 5,5'-((2-HYDROXY-1,3-PROPANEDIYL)BIS(OXY))BIS(4-OXO-), 5-[3-(2-carboxy-4-oxidanylidene-chromen-5-yl)oxy-2-oxidanyl-propoxy]-4-oxidanylidene-chromene-2-carboxylic acid, 5-[3-(2-carboxy-4-oxo-chromen-5-yl)oxy-2-hydroxy-propoxy]-4-oxo-chromene-2-carboxylic acid
Theoretical properties:
molecular_formula: C23H16O11
molecular_weight: 468.4 g/mol
exact_mass: 468.06926132 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 3
hydrogen_bond_acceptor_count: 11
rotatable_bond_count: 8
heavy_atom_count: 34
topological_polar_surface_area: 166 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
physical_state: Colorless crystals from ethanol + ether
color: Colorless crystals from ethanol + ether
Descriptions:
pubchem: Cromoglycic acid is a dicarboxylic acid that is the bis-chromone derivative of glycerol. It is effective as a mast cell stabilizer. It has a role as a calcium channel blocker and an anti-asthmatic drug. It is a member of chromones and a dicarboxylic acid. It is a conjugate acid of a cromoglycate(1-).
chebi: A  dicarboxylic acid that is the bis-chromone derivative of glycerol. It is effective as a mast cell stabilizer.
chembl: CROMOLYN is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Cromoglicic acid (INN)—also referred to as cromolyn (USAN), cromoglycate (former BAN), or cromoglicate—is traditionally described as a mast cell stabilizer, and is commonly marketed as the sodium salt sodium cromoglicate or cromolyn sodium.  This drug prevents the release of inflammatory chemicals such as histamine from mast cells.
It is considered a breakthrough drug in management of asthma, as the patients can be freed from steroids in many cases; however, it is mainly effective as a prophylaxis for allergic and exercise-induced asthma, not as a treatment for acute asthma attacks.
Cromoglicic acid has been the non-corticosteroid treatment of choice in the treatment of asthma, for which it has largely been replaced by leukotriene receptor antagonists because of their safety and convenience. Cromoglicic acid requires administration four times daily, and does not provide additive benefit in combination with inhaled corticosteroids.