Compound: progesterone
SMILES: O=C1C=C2[C@]([C@@H]3[C@H]([C@H]4[C@]([C@@H](C(=O)C)CC4)(C)CC3)CC2)(C)CC1
InChIKey: RJKFOVLPORLFTN-LEKSSAKUSA-N
Synonyms: progesterone, 57-83-0, Pregn-4-ene-3,20-dione, Agolutin, Crinone, Progestin, Utrogestan, Luteol, 4-Pregnene-3,20-dione, Gestormone, Glanducorpin, Prometrium, Syngesterone, Corlutin, Cyclogest, Gestone, Corlutina, Corluvite, Flavolutan, Fologenon, Gynolutone, Hormoflaveine, Hormoluton, Lucorteum, Luteostab, Lutociclina, Lutocyclin, Pregnenedione, Progestasert, Progesterol, Progesteronum, Progestone, Progestron, Corporin, Gesterol, Gestron, Gynlutin, Luteodyn, Luteogan, Luteopur, Luteosan, Luteovis, Lutidon, Nalutron, Lutin, Lutocyclin M, Bio-luton, Lipo-Lutin, Luteocrin normale, Methylpregnone, Progestosol, Progestronol, Syngestrets, Lingusorbs, Luteinique, Lutocylin, Lutoform, Lutogyl, Lutromone, Membrettes, Piaponon, Primolut, Progekan, Prolets, Prolidon, Proluton, Protormone, Syntolutan, Lutren, Lucorteum Sol, Prochieve, Prolutone, Synovex S, Endometrin, Gesterol 100, Gynoluton, Projestaject, 17alpha-Progesterone, Percutacrine Luteinique, Progeston, Pregnene-3,20-dione, Akrolutin, Gestiron, Progestogel, 3,20-Pregnene-4, (S)-Progesterone, Progesteron, Lutocylol, Progestol, Luteum, Crinone progesterone gel, Gelbkoerperhormon, NSC-9704, Progesterona, Vitarrine, (S)-4-Pregnene-3,20-dione, Delta(4)-pregnene-3,20-dione, (S)-Pregn-4-en-3,20-dione, beta-Progesterone, Lutogynon, Progesterone, micronized, DTXSID3022370, 17alpha-Hydroxy-6alpha-methylpregn-4-ene-3,20-dione, NSC-64377, MILPROSA, 4G7DS2Q64Y, CHEBI:17026, NSC9704, delta(Sup4)-pregnene-3,20-dione, (8S,9S,10R,13S,14S,17S)-17-Acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one, NSC64377, U 3672, DTXCID902370, Natural Progesterone, delta4-Pregnene-3,20-dione, Syngestrone, Lutigest, Progesta-care, Progesto-Life, Lutocylin M, Progesterone Combo, Serenity for women, Progesterone Phenolic, Synthetic Progestagen, Progesterone 1538, (8S,9S,10R,13S,14S,17S)-17-Acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta(a)phenanthren-3-one, RefChem:6165, Therapeutic Progesterone, P25 Progesterone Cream, P50 Progesterone Cream, P75 Progesterone Cream, EAZI-BREED CIDR Sheep, EAZI-BREED CIDR Cattle, P75 Lav Progesterone Cream, Advanced Formula Progesto-Life, CHEBI:59826, EAZI-BREED CIDR Sheep Insert, EAZI-BREED CIDR Cattle Insert, G03DA04, DTXCID801775313, P75 Maxx with Retinol All Natural Progesterone 75 Cream, (1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltetracyclo(8.7.0.02,7.011,15)heptadec-6-en-5-one, 200-350-6, DTXSID001346637, Lutex, Gesterol 50, Colprosterone, Cyclogesterin, Prolutin, Lugesteron, Lutocuclin M, Luteol (VAN), .beta.-Progesterone, Percutacrine, Progeffik, Utrogest, Estima, Progesteronum [INN-Latin], Progesterona [INN-Spanish], delta(sup 4)-Pregnene-3,20-dione, C21H30O2, CCRIS 533, Prontogest, 17.alpha.-Progesterone, HSDB 3389, Progesterone [Progestins], 4-Pregnen-3,20-dione, AI3-51682, Prometrium (TN), Pregn-4-en-3,20-dione, MFCD00003658, Crinone (TN), 6alpha-Methylpregn-4-en-17alpha-ol-3,20-dione, .delta.4-Pregnene-3,20-dione, Progesterone (Standard), Pregn-4-ene-3,20-dione, 17alpha-hydroxy-6alpha-methyl-, component of Cyclogesterin, .delta.(sup4)-Pregnene-3,20-dione, CHEMBL103, D4-Pregnene-3,20-dione, MLS000028517, (8S,9S,10R,13S,14S,17S)-17-Acetyl-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one, NCGC00015785-04, SMR000058345, 6.alpha.-Methylpregn-4-en-17.alpha.-ol-3,20-dione, 17.alpha.-Hydroxy-6.alpha.-methylpregn-4-ene-3,20-dione, 17a-Progesterone, Duraprogen, Pregesterone, Progestan, Pregn-4-ene-3,20-dione, 17.alpha.-hydroxy-6.alpha.-methyl-, (1S,10S,11S,14S,15S,2R)-14-acetyl-2,15-dimethyl-5-oxotetracyclo[8.7.0.0<2,7>.0 <11,15>]heptadec-6-ene, SMR000653542, CIDR, Progesterone (Prometrium), WLN: L E5 B666 OV MUTJ A1 E1 FV1, SR-01000000088, SR-01000076054, NSC 9704, EINECS 200-350-6, NSC 64377, Pregn-4-ene-3, 17.alpha.-hydroxy-6.alpha.-methyl-, BHR-100, UNII-4G7DS2Q64Y, Progestrel, Lipolutin, Lutinus, Progesterone RS, Progesterone CRS, 1dbb, CAS-57-83-0, Progesterone [USP:INN:BAN:JAN], racemic progesterone, Prestwick_411, Progesterone solution, mpp22, 2aa6, 4bb2, Opera_ID_292, Progesterone, >=99%, Prestwick0_000477, Prestwick1_000477, Prestwick2_000477, Prestwick3_000477, Spectrum5_002053, PROGESTERONE [MI], Cyclogesterin (Salt/Mix), PROGESTERONE [INN], PROGESTERONE [JAN], bmse000482, Epitope ID:116051, EC 200-350-6, PROGESTERONE [HSDB], SCHEMBL7671, ?4-Pregnene-3,20-dione, PROGESTERONE [VANDF], BIDD:PXR0094, Lopac0_000895, BSPBio_000614, PROGESTERONE [MART.], HUMAN SERUM (progesterone), MLS000758277, MLS001074187, MLS001423982, MLS002222367, BIDD:ER0547, P0130_SIGMA, PROGESTERONE [USP-RS], PROGESTERONE [WHO-DD], PROGESTERONE [WHO-IP], SPBio_002553, .delta.-Pregnene-3,20-dione, BDBM8903, BPBio1_000676, GTPL2377, Hydroxyprogesterone Caproic acid, orb1310573, orb3025169, SCHEMBL7610853, SCHEMBL8711607, HY-N0437R, Progesterone (JP18/USP/INN), BHR-310, ETI-411, MSK2223, PROGESTERONE [GREEN BOOK], 1a28, 1h60, HMS1569O16, HMS2051O05, HMS2090J07, HMS2096O16, HMS2230F23, HMS2233P11, HMS3262D12, HMS3713O16, Pregnene, 3,20-dione-delta^4-, PROGESTERONE [ORANGE BOOK], PROGESTERONE [EP MONOGRAPH], Progesterone in human serum (high), BIJUVA COMPONENT PROGESTERONE, HY-N0437, PROGESTERONE [USP MONOGRAPH], Tox21_113157, Tox21_201792, Tox21_300307, Tox21_500895, AC-700, CMC_13406, EBC-06111, LMST02030159, MSK2223-100A, Progesterone, 1mg/ml in Acetonitrile, PROGESTERONUM [WHO-IP LATIN], s1705, SBB012538, AKOS015894908, MSK2223-1000A, Progesterone; 4-Pregnene-3,20-dione, CCG-100766, CS-1937, DB00396, DR-2011, FD12045, FP27173, LP00895, NC00016, SDCCGSBI-0050870.P002, Progesterone 1.0 mg/ml in Acetonitrile, NCGC00022185-03, NCGC00022185-04, NCGC00022185-05, NCGC00022185-06, NCGC00022185-07, NCGC00022185-08, NCGC00022185-09, NCGC00022185-10, NCGC00022185-11, NCGC00022185-12, NCGC00022185-14, NCGC00022185-21, NCGC00090798-01, NCGC00090798-02, NCGC00254120-01, NCGC00259341-01, NCGC00261580-01, (8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one, AS-12660, CPD000058345, NCI60_042166, ST069329, FE-999913, CS-0694805, EU-0100895, NS00010899, P0478, T0478, (14beta,17alpha)-pregn-4-ene-3,20-dione, Progesterone, meets USP testing specifications, Progesterone, Vetec(TM) reagent grade, 98%, C00410, D00066, P 0130, Q26963, S00293, Progesterone Solution in Acetonitrile, 100ug/mL, Progesterone, VETRANAL(TM), analytical standard, F374675, Progesterone Solution in Acetonitrile, 1000ug/mL, SR-01000000088-5, SR-01000000088-6, SR-01000076054-1, SR-01000076054-4, BRD-K64994968-001-03-6, 32104FB6-BF81-4F6E-83C2-024DEEAEB272, Z1501485353, Progesterone, British Pharmacopoeia (BP) Reference Standard, Progesterone, powder, BioReagent, suitable for cell culture, Progesterone, European Pharmacopoeia (EP) Reference Standard, Progesterone, gamma-irradiated, BioXtra, suitable for cell culture, Progesterone, United States Pharmacopeia (USP) Reference Standard, Progesterone-Water Soluble, powder, BioReagent, suitable for cell culture, Progesterone for peak identification, European Pharmacopoeia (EP) Reference Standard, Progesterone for system suitability, European Pharmacopoeia (EP) Reference Standard, Progesterone, Pharmaceutical Secondary Standard; Certified Reference Material, (1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one, 137940-28-4
Theoretical properties:
molecular_formula: C21H30O2
molecular_weight: 314.5 g/mol
exact_mass: 314.224580195 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 1
heavy_atom_count: 23
topological_polar_surface_area: 34.1 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
physical_state: Prisms
color: Prisms
odor: Odorless
boiling_point: 394.13°C (rough estimate)
melting_point: 250 to 252 °F (NTP, 1992)
density: 1.171 at 68 °F (NTP, 1992) - Denser than water; will sink
solubility: less than 1 mg/mL at 66 °F (NTP, 1992)
Descriptions:
pubchem: Progesterone can cause cancer according to an independent committee of scientific and health experts.
chebi: A C<small><sub>21</sub></small>-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
chembl: PROGESTERONE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Progesterone ( ; P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. It belongs to a group of steroid hormones called the progestogens and is the major progestogen in the body. Progesterone has a variety of important functions in the body. It is also a crucial metabolic intermediate in the production of other endogenous steroids, including the sex hormones and the corticosteroids, and plays an important role in brain function as a neurosteroid.
In addition to its role as a natural hormone, progesterone is also used as a medication, such as in combination with estrogen for contraception, to reduce the risk of uterine or cervical cancer, in hormone replacement therapy, and in feminizing hormone therapy. It was first prescribed in 1934.