Compound: Pramocaine
SMILES: O1CCN(CCCOc2ccc(OCCCC)cc2)CC1
InChIKey: DQKXQSGTHWVTAD-UHFFFAOYSA-N
Synonyms: Pramocaine, pramoxine, 140-65-8, Proxazocain, pramocainum, 4-[3-(4-Butoxyphenoxy)propyl]morpholine, Pramocaina, 4-(3-(p-Butoxyphenoxy)propyl)morpholine, p-Butoxyphenyl gamma-morpholinopropyl ether, gamma-Morpholinopropyl 4-n-butoxyphenyl ether, CHEBI:8357, 4-(3-(4-butoxyphenoxy)propyl)morpholine, 068X84E056, DTXSID8040692, RefChem:55901, DTXCID6020692, C05AD07, D04AB07, 205-425-7, Tronopthane, Morpholine, 4-(3-(p-butoxyphenoxy)propyl)-, Pramocaine (INN), PRAMOCAINE [INN], Morpholine, 4-[3-(4-butoxyphenoxy)propyl]-, Pramocaine [INN:BAN], Pramocainum [INN-Latin], Pramocaina [INN-Spanish], NCGC00016529-01, CAS-637-58-1, EINECS 205-425-7, BRN 0239059, UNII-068X84E056, PX9, Spectrum_001380, PRAMOXINE [MI], Prestwick0_000716, Prestwick1_000716, Prestwick2_000716, Prestwick3_000716, Spectrum2_000030, Spectrum3_000925, Spectrum4_001024, Spectrum5_001511, PRAMOXINE [VANDF], CHEMBL1198, PRAMOCAINE [WHO-DD], SCHEMBL26020, BSPBio_000931, KBioGR_001547, KBioSS_001860, 4-27-00-00127 (Beilstein Handbook Reference), DivK1c_000882, SPBio_000099, SPBio_002852, BPBio1_001025, orb3028633, KBio1_000882, KBio2_001860, KBio2_004428, KBio2_006996, KBio3_001930, NINDS_000882, BDBM50225493, EBC-13068, DB09345, IDI1_000882, NCGC00016529-02, NCGC00016529-03, NCGC00016529-04, LS-14605, SBI-0051653.P002, HY-167645, 4-[3-(4-Butoxyphenoxy)propyl]morpholine #, AB00053605, Morpholine,4-[3-(4-butoxyphenoxy)propyl]-, NS00000592, p-Butoxyphenyl .gamma.-morpholinopropyl ether, .gamma.-Morpholinopropyl 4-n-butoxyphenyl ether, C07892, D08407, AB00053605_13, AB00053605_14, EN300-18530975, Q1240076, BRD-K46523383-003-04-7, BRD-K46523383-003-21-1, BRD-K46523383-003-22-9
Theoretical properties:
molecular_formula: C17H27NO3
molecular_weight: 293.4 g/mol
exact_mass: 293.19909372 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 4
rotatable_bond_count: 9
heavy_atom_count: 21
topological_polar_surface_area: 30.9 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Pramocaine is a member of the class of morpholines that is morpholine substituted at the nitrogen atom by a 3-(4-butoxyphenoxy)propyl group. It has a role as a local anaesthetic. It is an aromatic ether and a member of morpholines.
chebi: A member of the class of morpholines that is morpholine substituted at the nitrogen atom by a 3-(4-butoxyphenoxy)propyl group.
chembl: PRAMOXINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCl) is a topical anesthetic discovered at Abbott Laboratories in 1953 and used as an antipruritic. During research and development, pramocaine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent. Pharmacologic study revealed it to be potent and of low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index in humans. Like other local anesthetics, pramocaine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes is thus inhibited, leading to numbness. Notably, pramocaine is chemically distinct from other local anesthetics, being neither an amino amide nor an amino ester.