Compound: procarbazine
SMILES: O=C(NC(C)C)c1ccc(CNNC)cc1
InChIKey: CPTBDICYNRMXFX-UHFFFAOYSA-N
Synonyms: procarbazine, 671-16-9, Procarbazin, Ibenzmethyzin, Procarbazina, Procarbazinum, Procarbacine, N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine, p-(2-Methylhydrazinomethyl)-N-isopropylbenzamide, 2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine, N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide, 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine, 4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide, Ro 4-6467, N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide, N-Isopropyl-p-(2-methylhydrazinomethyl)-benzamide, N-(1-Methylethyl)-4-[(2-methylhydrazino)methyl]benzamide, p-(N'-Methylhydrazinomethyl)-N-isopropylbenzamide, Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]-, DTXSID4021189, N-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide, RO-4-6467 FREE BASE, 4-[(2-methylhydrazin-1-yl)methyl]-N-(propan-2-yl)benzamide, 35S93Y190K, p-Toluamide, N-isopropyl-alpha-(2-methylhydrazino)-, RO-4-6467, DTXCID301189, Benzamide, N-(1-methylethyl)-4-((2-methylhydrazino)methyl)-, CHEBI:71417, N-Isopropyl-4-((2-methylhydrazino)methyl)benzamide, Benzethyzin, 4-((2-methylhydrazin-1-yl)methyl)-N-(propan-2-yl)benzamide, RefChem:868533, L01XB01, 211-582-2, N-Methylhydrazine, Natulan, Ibenzmethyzine, Procarbazin [German], Procarbazinum [INN-Latin], Procarbazina [INN-Spanish], N-Isopropyl-4-((2-methylhydrazinyl)methyl)benzamide, 4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide, Procarbazine free base, CB 400-497, MIH, Procarbazine (INN), PCX, CB 400-497; Ibenzmethyzine; MIH, p-Toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)-, Ro-4646711, PROCARBAZINE [INN], Procarbazine [INN:BAN], N-Isopropyl-.alpha.-(2-methylhydrazino)-p-toluamide, CCRIS 2389, HSDB 3250, NCGC00016438-01, CAS-366-70-1, IBZ, EINECS 211-582-2, BRN 0958270, SR-01000763375, 671-16-9 (free base), UNII-35S93Y190K, SRI-10847, MBH (Salt/Mix), Matulane (Salt/Mix), Nathulane (Salt/Mix), Natunalar (Salt/Mix), Prestwick0_001112, Prestwick1_001112, Prestwick2_001112, Prestwick3_001112, PROCARBAZINE [MI], PROCARBAZINE [HSDB], SCHEMBL4656, CHEMBL1321, NCIOpen2_004074, PROCARBAZINE [VANDF], BSPBio_001244, BIDD:GT0183, PROCARBAZINE [WHO-DD], SPBio_003112, BPBio1_001369, GTPL7278, orb1707490, GLXC-08182, HMS2090J09, Pharmakon1600-01502326, Tox21_301738, BDBM50247906, EBC-26230, EX-A15361, HY-13733A, NSC759626, STL483417, AKOS015891211, AC-4547, CCG-213031, DB01168, NSC-759626, NCGC00016438-02, NCGC00016438-05, NCGC00255280-01, Ro-46467/1, CAS-671-16-9, NCI60_041703, SRI-10847-09, SRI-10847-10, SRI-10847_11, SRI-10847_13, DB-082065, CS-0012387, NS00003685, C07402, D08423, EN300-708801, Q418656, SR-01000763375-3, BRD-K13032584-001-01-5, BRD-K13032584-003-18-5, BRD-K13032584-003-19-3, BRD-K13032584-003-21-9, N-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide #, 4-[(2-methylhydrazinyl)methyl]-N-(propan-2-yl)benzamide
Theoretical properties:
molecular_formula: C12H19N3O
molecular_weight: 221.30 g/mol
exact_mass: 221.152812238 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 3
hydrogen_bond_acceptor_count: 3
rotatable_bond_count: 5
heavy_atom_count: 16
topological_polar_surface_area: 53.2 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
vapor_pressure: 8.4X10-7 mm Hg @ 25 °C /Estimated/
Descriptions:
pubchem: Procarbazine can cause cancer according to an independent committee of scientific and health experts.
chebi: A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
chembl: PROCARBAZINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Procarbazine is a chemotherapy medication used for the treatment of Hodgkin lymphoma and brain cancers. For Hodgkin lymphoma it is often used together with chlormethine, vincristine, and prednisone while for brain cancers such as glioblastoma multiforme it is used with lomustine and vincristine. It is typically taken by mouth.
Common side effect include low blood cell counts and vomiting. Other side effects include tiredness and depression. It is not recommended in people with severe liver or kidney problems. Use in pregnancy is known to harm the baby. Procarbazine is in the alkylating agents family of medication. How it works is not clearly known.
Procarbazine was approved for medical use in the United States in 1969. It is on the World Health Organization's List of Essential Medicines. In the United Kingdom a month of treatment cost the National Health Service 450 to 750 pounds.