Compound: o-Tolidine
SMILES: Nc1c(cc(-c2cc(c(N)cc2)C)cc1)C
InChIKey: NUIURNJTPRWVAP-UHFFFAOYSA-N
Synonyms: o-Tolidine, 119-93-7, 3,3'-DIMETHYLBENZIDINE, Orthotolidine, Diaminoditolyl, 2-Tolidine, Bianisidine, Diaminotolyl, 4,4'-Bi-o-toluidine, 3,3'-Tolidine, Fast Dark Blue Base R, 3,3'-Dimethyl-4,4'-biphenyldiamine, 3,3'-Dimethyl-4,4'-diaminobiphenyl, 4,4'-Diamino-3,3'-dimethylbiphenyl, 2-Tolidina, 3,3'-Dimethylbiphenyl-4,4'-diamine, 2-Tolidin, 4,4'-Di-o-toluidine, [1,1'-Biphenyl]-4,4'-diamine, 3,3'-dimethyl-, RCRA waste number U095, o-Tolidin, 3,3'-dimethyl-[1,1'-biphenyl]-4,4'-diamine, Tolidine, o-, C.I. 37230, C.I. Azoic Diazo Component 113, CCRIS 256, 3,3-Dimethylbenzidine, 3,3'-Dimethyl-4,4'-diphenyldiamine, 4,4'-Diamino-3,3'-dimethyldiphenyl, CI Azoic diazo component 113, DTXSID5024059, o,o'-Tolidine, 63HLO2IV6K, 3,3'-Dimethyl-(1,1'-biphenyl)-4,4'-diamine, BRN 2210640, CI 37230, AI3-19499, (1,1'-Biphenyl)-4,4'-diamine, 3,3'-dimethyl-, DTXCID504059, 4-13-00-00419 (Beilstein Handbook Reference), 3,3'-Dimethyldiphenyl-4,4'-diamine, tolidine blue, 3,3'-Dimethylbenzidin, RefChem:167311, (1,1'-Biphenyl)-4,4'-diamine-3,3'-dimethyl-, 204-358-0, 4-(4-amino-3-methylphenyl)-2-methylaniline, Benzidine, 3,3'-dimethyl-, MFCD00014773, 2-Tolidin [German], 2-Tolidina [Italian], CAS-119-93-7, HSDB 1640, 4-(4-amino-3-methylphenyl)-2-methylphenylamine, EINECS 204-358-0, RCRA waste no. U095, UNII-63HLO2IV6K, 4-(4-amino-3-methyl-phenyl)-2-methyl-aniline, o-Tolidine, minimum, 4,4'-Bianisidine, O-TOLIDINE [MI], ORTHOTOLIDINE [HSDB], SCHEMBL49414, SCHEMBL49448, o-Tolidine, Powder, Reagent, MLS002302992, BIDD:ER0325, BIDD:GT0296, CHEMBL85109, o-Tolidine, >=97%, powder, o-Tolidine, analytical standard, SCHEMBL29365329, SCHEMBL29386552, CHEBI:34320, o-Tolidine, p.a., 98.0%, MSK1212, HMS3039P16, DIMETHYLBENZIDINE, 3,3'-, Tox21_201292, Tox21_300278, BBL027811, MSK1212-100M, SBB008947, STL387858, o-Tolidine (3,3'-dimethylbenzidine), AKOS004901441, MSK1212-1000M, FT62332, NCGC00090865-01, NCGC00090865-02, NCGC00090865-04, NCGC00090865-05, NCGC00253962-01, NCGC00258844-01, AS-17225, SMR001307308, biphenyl, 4,4'-diamino-3,3'-dimethyl-, DB-028240, NS00015707, ST45255326, T1913, EN300-94759, 3,3'-Dimethyl[1,1'-biphenyl]-4,4'-diamine, D95238, Q413500, 3,3-Dimethylbenzidine 100 microg/mL in Acetonitrile, 3,3'-Dimethylbenzidine Solution in Methanol, 1000ug/mL, 3,3'-Dimethylbenzidine Solution in Methanol, 100ug/mL, 4'-Amino-3,3'-dimethyl[1,1'-biphenyl]-4-ylamine #, F1908-0142, 3,3'-dimethyl-[1,1'-biphenyl]-4,4'- Diamine (O-Tolidine), InChI=1/C14H16N2/c1-9-7-11(3-5-13(9)15)12-4-6-14(16)10(2)8-12/h3-8H,15-16H2,1-2H
Theoretical properties:
molecular_formula: C14H16N2
molecular_weight: 212.29 g/mol
exact_mass: 212.131348519 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 2
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 1
heavy_atom_count: 16
topological_polar_surface_area: 52 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
physical_state: Colorless; in technical grades also brownish flakes
color: Colorless; in technical grades also brownish flakes
boiling_point: 392 °F at 760 mmHg (NTP, 1992)
melting_point: 264 to 268 °F (NTP, 1992)
density: 1 (NTP, 1992)
solubility: less than 1 mg/mL at 66 °F (NTP, 1992)
flash_point: 137 °C
vapor_pressure: 0.000001 [mmHg]
Descriptions:
pubchem: 3,3'-Dimethylbenzidine (ortho-Tolidine) can cause cancer according to an independent committee of scientific and health experts.
chembl: ORTHOTOLIDINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase -1.0.
wikipedia: 2-Tolidine (orthotolidine, o-tolidine; not to be confused with o-toluidine) is an organic compound with the chemical formula (C6H4(CH3)NH2)2. Several isomers are known; the 3-tolidine derivative is also important commercially. It is a colorless compound although commercial samples are often colored. It is slightly soluble in water. It forms salts with acids, such as the hydrochloride, which is commercially available.
2-Tolidine can be produced by benzidine rearrangement from a hydrazone derivative of 2-nitrotoluene.

(CH3C6H4)2N2H2  →  (C6H3(CH3)NH2)2