Compound: Sch 58261
SMILES: o1c(-c2nn3c(nc4c(c3n2)cnn4CCc5ccccc5)N)ccc1
InChIKey: UTLPKQYUXOEJIL-UHFFFAOYSA-N
Synonyms: Sch 58261, 160098-96-4, Sch58261, 4309023MAH, DTXSID80166799, 2-(2-Furanyl)-7-(2-phenylethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, 5-Amino-7-(2-phenylethyl)-2-(2-furyl)-pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine, 4-(furan-2-yl)-10-(2-phenylethyl)-3,5,6,8,10,11-hexaazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2,4,7,11-pentaen-7-amine, 2-(2-Furanyl)-7-(2-phenylethyl)-7H-pyrazolo(4,3-e)(1,2,4)triazolo(1,5-c)pyrimidin-5-amine, 4-(furan-2-yl)-10-(2-phenylethyl)-3,5,6,8,10,11-hexaazatricyclo(7.3.0.0^(2,6))dodeca-1(9),2,4,7,11-pentaen-7-amine, RefChem:884671, DTXCID8089290, 836-097-9, Sch-58261, 2-(Furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, MFCD00933778, C18H15N7O, CHEMBL17127, 7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine, 7H-Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, 2-(2-furanyl)-7-(2-phenylethyl)-, 4-(furan-2-yl)-10-(2-phenylethyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-7-amine, 2-Furan-2-yl-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine, 7H-Pyrazolo(4,3-e)(1,2,4)triazolo(1,5-c)pyrimidin-5-amine, 2-(2-furanyl)-7-(2-phenylethyl)-, UNII-4309023MAH, [3H]SCH 58261, GTPL403, GTPL431, SCHEMBL537287, orb1300293, CHEBI:93424, GLXC-06761, HMS3263L20, HMS3268F20, HMS3413A10, HMS3677A10, HMS3748I07, HMS3886N04, EX-A1464, Tox21_501259, BDBM50048466, PDSP1_001199, PDSP2_001183, s8104, SCH58261?, SP-341, AKOS022181216, [3H]-SCH 58261, CCG-222563, CS-5639, LP01259, SDCCGSBI-0633817.P001, NCGC00092350-01, NCGC00092350-02, NCGC00092350-09, NCGC00261944-01, AC-32732, AS-16830, BS162679, HY-19533, SY122064, DB-043446, C3599, SCH 58261, >=98% (HPLC), solid, L000548, Q7389140, BRD-K81225797-001-01-5, BRD-K81225797-001-02-3, 5-Amino-2-(2-Furyl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine, 5-amino-7-(phenylethyl)-2-(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine, 2-(Furan-2-yl)-7-(2-phenylethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, 2-Furan-2-yl-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine(SCH 58261), 4-(2-furyl)-10-(2-phenylethyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-7-amine
Theoretical properties:
molecular_formula: C18H15N7O
molecular_weight: 345.4 g/mol
exact_mass: 345.13380813 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 6
rotatable_bond_count: 4
heavy_atom_count: 26
topological_polar_surface_area: 100 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: LSM-3822 is a member of triazolopyrimidines.
chembl: SCH-58261 is a small molecule listed in the ChEMBL database but has not progressed to an approved clinical phase.
wikipedia: SCH-58261 is a drug which acts as a potent and selective antagonist for the adenosine receptor A2A, with more than 50x selectivity for A2A over other adenosine receptors. It has been used to investigate the mechanism of action of caffeine, which is a mixed A1 / A2A antagonist, and has shown that the A2A receptor is primarily responsible for the stimulant and ergogenic effects of caffeine, but blockade of both A1 and A2A receptors is required to accurately replicate caffeine's effects in animals. SCH-58261 has also shown antidepressant, nootropic and neuroprotective effects in a variety of animal models, and has been investigated as a possible treatment for Parkinson's disease.