Compound: Prosidol free base
SMILES: O=C(OC1(c2ccccc2)CCN(CCOCC)CC1)CC
InChIKey: IOLPYQBYMPDUNK-UHFFFAOYSA-N
Synonyms: Prosidol free base, CV69EOR0N2, UNII-CV69EOR0N2, 4-Piperidinol, 1-(2-ethoxyethyl)-4-phenyl-, 4-propanoate, 4-Piperidinol, 1-(2-ethoxyethyl)-4-phenyl-, propanoate (ester), 164231-04-3, RefChem:202757, SCHEMBL15734501, Q7250607, 1-(2-ethoxyethyl)-4-phenyl-4-propionyl-oxypiperidine, [1-(2-ethoxyethyl)-4-phenylpiperidin-4-yl] propanoate
Theoretical properties:
molecular_formula: C18H27NO3
molecular_weight: 305.4 g/mol
exact_mass: 305.19909372 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 4
rotatable_bond_count: 8
heavy_atom_count: 22
topological_polar_surface_area: 38.8 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
{"pubchem": null, "chebi": null, "chembl": null, "wikipedia": "Opioids are a class of drugs that derive from, or mimic, natural substances found in the opium poppy plant. Opioids work on opioid receptors in the brain and other organs to produce a variety of morphine-like effects, including pain relief.\nThe terms \"opioid\" and \"opiate\" are sometimes used interchangeably, but the term \"opioid\" is used to designate all substances, both natural and synthetic, that bind to opioid receptors in the brain. Opiates are alkaloid compounds naturally found in the opium poppy plant Papaver somniferum.\nMedically they are primarily used for pain relief, including anesthesia. Other medical uses include suppression of diarrhea, replacement therapy for opioid use disorder, and suppressing cough. The opioid receptor antagonist naloxone is used to reverse opioid overdose. Extremely potent opioids such as carfentanil are approved only for veterinary use. Opioids are also frequently used recreationally for their euphoric effects or to prevent withdrawal. Opioids can be fatal, and have been used, alone and in combination, in a small number of executions in the United States.\nSide effects of opioids may include itchiness, sedation, nausea, respiratory depression, constipation, and euphoria. Long-term use can cause tolerance, meaning that increased doses are required to achieve the same effect, and physical dependence, meaning that abruptly discontinuing the drug leads to unpleasant withdrawal symptoms. The euphoria attracts recreational use; frequent, escalating recreational use of opioids typically results in addiction. An overdose or concurrent use with other depressant drugs like benzodiazepines can result in death from respiratory depression.\nOpioids act by binding to opioid receptors, which are found principally in the central and peripheral nervous system and the gastrointestinal tract. These receptors mediate both the psychoactive and the somatic effects of opioids. Partial agonists, like the anti-diarrhea drug loperamide and antagonists, like naloxegol for opioid-induced constipation, do not cross the blood\u2013brain barrier, but can displace other opioids from binding to those receptors in the myenteric plexus.\nBecause opioids are addictive and may result in fatal overdose, most are controlled substances. In 2013, between 28 and 38 million people used opioids illicitly (0.6% to 0.8% of the global population between the ages of 15 and 65). By 2021, that number rose to 60 million. In 2011, an estimated 4 million people in the United States used opioids recreationally or were dependent on them. As of 2015, increased rates of recreational use and addiction are attributed to over-prescription of opioid medications and inexpensive illicit heroin. Conversely, fears about overprescribing, exaggerated side effects, and addiction from opioids are similarly blamed for under-treatment of pain."}