Compound: Oxyphenisatine
SMILES: O=C1Nc2ccccc2C1(c3ccc(O)cc3)c4ccc(O)cc4
InChIKey: SJDACOMXKWHBOW-UHFFFAOYSA-N
Synonyms: Oxyphenisatine, Oxyphenisatin, 125-13-3, 3,3-Bis(p-hydroxyphenyl)oxindole, Phenolisatin, Dihydroxyphenoloxindol, 4,4'-Dihydroxydiphenylisatin, Oxifenisatina, 3,3-Bis(4-hydroxyphenyl)oxindole, 3,3-Bis(p-hydroxyphenyl)-2-indolinone, Oxyphenisatinum, 1,3-Dihydro-3,3-bis(4-hydroxyphenyl)-2H-indol-2-one, 3BT0VQG2GQ, NSC-59814, DTXSID5044528, DTXCID3024528, RefChem:169069, phenlaxinum (for the acetate), 3,3-bis(4-hydroxyphenyl)-2,3-dihydro-1H-indol-2-one, acetphenolisatinum (for the acetate), 204-728-1, Isaphen, Propellax, Recolon, Diphenolisatin, Isatinbisphenol, Hoscolax, Neodrast, Normalax, Critex, Isolax, 2H-Indol-2-one, 1,3-dihydro-3,3-bis(4-hydroxyphenyl)-, 3,3-bis(4-hydroxyphenyl)indolin-2-one, NSC 59814, Oxindole, 3,3-bis(p-hydroxyphenyl)-, 3,3-Bis(4-hydroxyphenyl)-oxindole, MFCD00022794, Oxiphenisatinum, 2-INDOLINONE, 3,3-BIS(p-HYDROXYPHENYL)-, Oxyphenisatine (INN), OXYPHENISATINE [INN], Oxifenisatina [INN-Spanish], Oxyphenisatinum [INN-Latin], Nourilax, Oxyphenisatine [INN:BAN], CAS-125-13-3, 3,3-bis(4-hydroxyphenyl)-1H-indol-2-one, EINECS 204-728-1, UNII-3BT0VQG2GQ, BRN 0286070, Isaphen (TN), Oxyphenisatine (Standard), 3,3-bis-(4-Hydroxyphenyl)-2(3H)-indolone, NCIOpen2_007896, 5-21-13-00398 (Beilstein Handbook Reference), SCHEMBL239513, OXYPHENISATINE [MART.], CHEMBL245807, orb1741479, SCHEMBL8777299, OXYPHENISATINE [WHO-DD], 3,3-Bis(4-hydroxyphenyl)-1,3-dihydro-2H-indol-2-one, HY-B2102R, CHEBI:135358, HY-B2102, NSC59814, Tox21_113927, Tox21_301931, SBB008302, ZB1280, 3,3-bis-(4-hydroxyphenyl)-oxindole, 2-Indolinone,3-bis(p-hydroxyphenyl)-, AKOS003628613, CS-6312, DB04823, FO65118, NCGC00255866-01, NCGC00262932-01, AS-76819, DB-080971, NS00005188, ST50410650, D08326, F85523, F342089, SR-01000196726, Q7116108, SR-01000196726-1, 2H-Indol-2-one,3-dihydro-3,3-bis(4-hydroxyphenyl)-, 3,3-Bis(4-hydroxyphenyl)-1,3-dihydro-2H-indol-2-one #
Theoretical properties:
molecular_formula: C20H15NO3
molecular_weight: 317.3 g/mol
exact_mass: 317.10519334 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 3
hydrogen_bond_acceptor_count: 3
rotatable_bond_count: 2
heavy_atom_count: 24
topological_polar_surface_area: 69.6 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Oxyphenisatine is a member of indoles.
chembl: OXYPHENISATINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Oxyphenisatine (or oxyphenisatin) is a laxative.   It is closely related to bisacodyl, sodium picosulfate, and phenolphthalein. Long-term use is associated with liver damage, and as a result, it was withdrawn in most countries in the early 1970s.  The acetate derivative oxyphenisatine acetate was also once used as a laxative.
Natural chemical compounds similar to oxyphenisatine may be present in prunes, but a recent review of the relevant scientific literature suggests that the laxative effect of prunes is due to other constituents including phenolic compounds (mainly neochlorogenic acids and chlorogenic acids) and sorbitol.  Oxyphenisatin has cathartic properties.