Compound: bepridil
SMILES: O(CC(N1CCCC1)CN(c2ccccc2)Cc3ccccc3)CC(C)C
InChIKey: UIEATEWHFDRYRU-UHFFFAOYSA-N
Synonyms: bepridil, 64706-54-3, DTXSID3022663, N-benzyl-N-[3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl]aniline, 755BO701MA, CHEBI:3061, DTXCID402663, 1-Pyrrolidineethanamine, beta-((2-methylpropoxy)methyl)-N-phenyl-N-(phenylmethyl)-, 1-(2-(N-BENZYLANILINO)-1-(ISOBUTOXYMETHYL)ETHYL)-PYRROLIDINE, bepridilum, Bedapin, N-benzyl-N-(3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl)aniline, Bepridil, alpha, N-(3-(2-methylpropoxy)-2-pyrrolidin-1-ylpropyl)-N-(phenylmethyl)aniline, N-[3-(2-methylpropoxy)-2-pyrrolidin-1-ylpropyl]-N-(phenylmethyl)aniline, RefChem:567017, Monohydrochloride, Bepridil, CERM1978, 1978 CERM, 1978-CERM, Bepridil Monohydrochloride, alpha, C08EA02, Monohydrochloride, alpha-Isomer Bepridil, 1-PYRROLIDENEETHANAMINE, BETA-((2-METHYLPROPOXY)METHYL)-N-PHENYL-N-(PHENYLMETHYL)-, 256-384-7, Bepadin, N-Benzyl-N-(3-isobutoxy-2-(pyrrolidin-1-yl)propyl)aniline, N-benzyl-N-[3-(2-methylpropoxy)-2-pyrrolidin-1-ylpropyl]aniline, C24H34N2O, Bepridil (INN), CERM 1978, NCGC00015155-03, BEPRIDIL [INN], N-Benzyl-N-[3-(2-methylpropoxy)-2-pyrrolidin-1-yl-propyl]aniline hydrochloride, Org 5730, Bepridil free base, Bepadin (TN), (+/-)-Bepridil;Org 5730; dl-Bepridil, CAS-64706-54-3, Bepridil [INN:BAN], UNII-755BO701MA, 64706-54-3 (free base), beta-((2-Methylpropoxy)methyl)-N-phenyl-N-(phenylmethyl)-1-pyrrolidineethanamine, MFCD00868313, Spectrum_001745, BEPRIDIL [MI], BEPRIDIL [VANDF], Prestwick0_000368, Prestwick1_000368, Prestwick2_000368, Prestwick3_000368, Spectrum2_000901, Spectrum3_000747, Spectrum4_000797, Spectrum5_000978, BEPRIDIL [WHO-DD], CHEMBL1008, Lopac0_000222, SCHEMBL34412, BSPBio_000495, BSPBio_001301, BSPBio_002334, KBioGR_000021, KBioGR_001274, KBioSS_000021, KBioSS_002225, cid_50088, DivK1c_000110, SPBio_000742, SPBio_002416, BPBio1_000545, GTPL2337, orb1689892, BCBcMAP01_000130, BDBM78577, KBio1_000110, KBio2_000021, KBio2_002225, KBio2_002589, KBio2_004793, KBio2_005157, KBio2_007361, KBio3_000041, KBio3_000042, KBio3_001554, NINDS_000110, Bio1_000388, Bio1_000877, Bio1_001366, Bio2_000021, Bio2_000501, HMS1361B03, HMS1791B03, HMS1989B03, HMS2089C05, Tox21 110089, Tox21_110089, EBC-26808, HSCI1_000377, ()-Bepridil;Org 5730; dl-Bepridil, AKOS015962267, N-{3-[(2-methylpropyl)oxy]-2-pyrrolidin-1-ylpropyl}-N-(phenylmethyl)aniline, Tox21_110089_1, CCG-204317, DB01244, SDCCGSBI-0050210.P003, IDI1_000110, IDI1_033771, NCGC00015155-02, NCGC00015155-04, NCGC00015155-05, NCGC00015155-06, NCGC00015155-07, NCGC00015155-08, NCGC00015155-11, NCGC00015155-13, NCGC00015155-19, NCGC00162097-01, NCGC00162097-02, NCGC00162097-03, NCGC00162097-04, 864868-68-8, AC-16059, HY-16952, DB-054717, AB00053643, CS-0013008, NS00002270, C06847, D07520, AB00053643-14, AB00053643_15, EN300-22786142, Q4890934, BRD-A91008255-001-02-8, BRD-A91008255-003-16-4, BRD-A91008255-003-24-8, BRD-A91008255-003-25-5, N-benzyl-N-(3-isobutoxy-2-pyrrolidin-1-yl-propyl)aniline, benzyl-(3-isobutoxy-2-pyrrolidino-propyl)-phenyl-amine;hydrochloride, N-[3-(2-methylpropoxy)-2-(1-pyrrolidinyl)propyl]-N-(phenylmethyl)aniline;hydrochloride, N-[3-(2-methylpropoxy)-2-pyrrolidin-1-yl-propyl]-N-(phenylmethyl)aniline;hydrochloride, 1-PYRROLIDENEETHANAMINE, .BETA.-((2-METHYLPROPOXY)METHYL)-N-PHENYL-N-(PHENYLMETHYL)-, 1-Pyrrolidineethanamine, .beta.-[(2-methylpropoxy)methyl]-N-phenyl-N-(phenylmethyl)-, monohydrochloride
Theoretical properties:
molecular_formula: C24H34N2O
molecular_weight: 366.5 g/mol
exact_mass: 366.267113712 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 3
rotatable_bond_count: 10
heavy_atom_count: 27
topological_polar_surface_area: 15.7 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
solubility: Slightly soluble
Descriptions:
pubchem: Bepridil is a tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl. It has a role as a vasodilator agent, an antihypertensive agent, an anti-arrhythmia drug and a calcium channel blocker. It is a tertiary amine and a member of pyrrolidines.
chebi: A tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl.
chembl: BEPRIDIL is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Bepridil (trade name Vascor) is an diamine calcium channel blocker once used to treat angina pectoris. It is no longer sold in the United States.
It is nonselective.
It has been discussed as a possible option in the treatment of atrial fibrillation.
It has been implicated in causing ventricular arrhythmia (torsades de pointes).