Compound: tilorone
SMILES: O=C1c2c(ccc(c2)OCCN(CC)CC)-c3c1cc(OCCN(CC)CC)cc3
InChIKey: MPMFCABZENCRHV-UHFFFAOYSA-N
Synonyms: tilorone, 27591-97-5, Bis-DEAE-fluorenone, Tilorona, Tiloronum, 9H-Fluoren-9-one, 2,7-bis[2-(diethylamino)ethoxy]-, 2,7-Bis(2-(diethylamino)ethoxy)-9H-fluoren-9-one, O6W7VEW6KS, DTXSID1045958, 2,7-bis[2-(diethylamino)ethoxy]-9H-fluoren-9-one, DTXCID9025958, 9H-FLUOREN-9-ONE, 2,7-BIS(2-(DIETHYLAMINO)ETHOXY)-, CHEBI:147347, Bis DEAE Fluorenone, RefChem:933073, J05AX19, 2,7-Bis-(2-diethylamino-ethoxy)-fluoren-9-one, Tilorone [INN], 2,7-Bis-DEAE-fluorenone, 2,7-bis[2-(diethylamino)ethoxy]fluoren-9-one, Amixin IC, DEAE-F, RMI 10008DA, NCGC00095196-01, Tiloronum [INN-Latin], Tilorona [INN-Spanish], CAS-27591-97-5, NSC143969, UNII-O6W7VEW6KS, BRN 2011558, 2,7-Bis(2-diethylaminoethoxy)fluoren-9-one dihydrochloride, MFCD00866953, Spectrum_000231, TILORONE [MI], Spectrum2_001742, Spectrum3_001055, Spectrum5_001889, ChemDiv1_019101, 2,7-bis(2-diethylaminoethyloxy)fluoren-9-one, TILORONE [WHO-DD], 2,7-Bis[2-(diethylamino)ethoxy]-9-fluorenone, Tiloron (*dihydrochloride*), Oprea1_331997, BSPBio_002610, KBioSS_000711, Tilorone hydrochloride(USAN), CHEMBL47298, DivK1c_000018, SCHEMBL352401, SPECTRUM2300009, SPBio_001844, SCHEMBL29500271, SCHEMBL30520073, HMS500A20, HMS641E05, HY-B1080A, KBio1_000018, KBio2_000711, KBio2_003279, KBio2_005847, KBio3_001830, CHEBI:109553, MPMFCABZENCRHV-UHFFFAOYSA-N, NINDS_000018, HMS1922J22, HMS2094I17, Pharmakon1600-02300009, Tox21_111484, BDBM50364890, CCG-39449, NSC759311, RMI 10008DA (*dihydrochloride*), STL483841, AKOS025310183, Tox21_111484_1, NSC-759311, IDI1_000018, Bis-DEAE-fluorenone (*dihydrochloride*), NCGC00095196-02, NCGC00095196-03, NCGC00095196-04, NCGC00095196-06, NCGC00178576-01, AC-24571, AS-14877, SBI-0052826.P002, CS-0013836, G78315, AB00053319_02, SR-05000001961, Q2028068, SR-05000001961-1, BRD-K34568562-001-03-5, BRD-K34568562-001-04-3, BRD-K34568562-300-01-5, 2, {7-Bis[2-(diethylamino)ethoxy]fluoren-9-one} dihydrochloride, 9H-Fluoren-9-one, {2,7-bis[2-(diethylamino)ethoxy]-,} dihydrochloride, Fluoren-9-one, 2, {7-bis[2-(diethylamino)ethoxy]-,} dihydrochloride
Theoretical properties:
molecular_formula: C25H34N2O3
molecular_weight: 410.5 g/mol
exact_mass: 410.25694295 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 5
rotatable_bond_count: 12
heavy_atom_count: 30
topological_polar_surface_area: 42 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Tilorone is a member of the class of fluoren-9-ones that is 9H-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is an interferon inducer and a selective alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonist. Its hydrochloride salt is used as an antiviral drug. It has a role as an antiviral agent, an antineoplastic agent, an interferon inducer, an EC 3.1.1.7 (acetylcholinesterase) inhibitor, a nicotinic acetylcholine receptor agonist and an anti-inflammatory agent. It is a member of fluoren-9-ones, an aromatic ether, a diether and a tertiary amino compound. It is a conjugate base of a tilorone(2+).
chebi: A member of the class of fluoren-9-ones that is 9<em>H</em>-fluoren-9-one which is substituted by a 2-(diethylamino)ethoxy group at positions 2 and 7. It is an interferon inducer and a selective α7 nicotinic acetylcholine receptor (α7 nAChR) agonist. Its hydrochloride salt is used as an antiviral drug.
chembl: TILORONE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 2.0.
wikipedia: Tilorone (trade names Amixin, Lavomax and others) is the first recognized synthetic, small molecular weight compound that is an orally active interferon inducer. It is used as an antiviral drug in some countries which do not require double-blind placebo-controlled studies, including Russia. It is effective against Ebola virus in mice. It shows activity against Eastern equine encephalitis and related viruses.