Compound: Tariquidar
SMILES: O=C(Nc1ccc(CCN2Cc3c(cc(OC)c(c3)OC)CC2)cc1)c4c(NC(=O)c5cnc6ccccc6c5)cc(OC)c(c4)OC
InChIKey: LGGHDPFKSSRQNS-UHFFFAOYSA-N
Synonyms: Tariquidar, 206873-63-4, XR9576, XR 9576, N-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide, N-(2-((4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)carbamoyl)-4,5-dimethoxyphenyl)quinoline-3-carboxamide, XR-9576, J58862DTVD, DTXSID10174746, tariquidarth, N-[2-({4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]phenyl}carbamoyl)-4,5-dimethoxyphenyl]quinoline-3-carboxamide, tariquidarum, N-(2-((4-(2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl)phenyl)carbamoyl)-4,5-dimethoxyphenyl)quinoline-3-carboxamide, N-(2-((4-(2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl)phenyl)carbamoyl)-4,5-dimethoxyphenyl)quinoline-3-carboxamide, N-[2-({4-[2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl]phenyl}carbamoyl)-4,5-dimethoxyphenyl]quinoline-3-carboxamide, N-[2-[[4-[2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide, RefChem:891172, DTXCID6097237, 110-912-1, C38H38N4O6, MFCD09837824, 3-QUINOLINECARBOXAMIDE, N-[2-[[[4-[2-(3,4-DIHYDRO-6,7-DIMETHOXY-2(1H)-ISOQUINOLINYL)ETHYL]PHENYL]AMINO]CARBONYL]-4,5-DIMETHOXYPHENYL]-, CHEMBL348475, 3-Quinolinecarboxamide,N-(2-(((4-(2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl)phenyl)amino)carbonyl)-4,5-dimethoxyphenyl)-, Tariquidar [USAN], Tariquidar (USAN/INN), UNII-J58862DTVD, Tariquidar [USAN:INN:BAN], 3-Quinolinecarboxamide, N-(2-(((4-(2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl)phenyl)amino)carbonyl)-4,5-dimethoxyphenyl)-, N-[2-[[[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-3-quinolinecarboxamide; XR 9576;, R1H, TARIQUIDAR [MI], TARIQUIDAR [INN], Tariquidar (XR9576)?, TARIQUIDAR [WHO-DD], MLS006011218, N-[2-[[4-[2-(6,7-DIMETHOXY-3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)ETHYL]PHENYL]CARBAMOYL]-4,5-DIMETHOXY-PHENYL]QUINOLINE-3-CARBOXAMIDE, SCHEMBL104163, orb1300901, SCHEMBL21545178, SCHEMBL29387021, SCHEMBL29558585, Tariquidar, >=98% (HPLC), GTPL11787, EX-A231, CHEBI:177609, GLXC-90256, HMS3653L21, BDBM50075373, s8028, AKOS016008964, CCG-270326, compound 2 [PMID: 10098671], CS-0722, DB06240, EBC-294042, FT46245, PB29709, NCGC00346448-01, NCGC00346448-06, NCGC00346448-08, AC-31048, AS-75190, DA-08376, HY-10550, N-(2-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenylcarbamoyl)-4,5-dimethoxyphenyl)quinoline-3-carboxamide, SMR004702980, NS00069844, SW219804-1, D06008, Q7686198, BRD-K09353376-001-02-1, BRD-K09353376-001-03-9, 1N-{4-[2-(6,7-dimethoxy-1,2,3,4-tetrahydro-2-isoquinolinyl)ethyl]phenyl}-4,5-dimethoxy-2-(3-quinolylcarboxamido)benzamide
Theoretical properties:
molecular_formula: C38H38N4O6
molecular_weight: 646.7 g/mol
exact_mass: 646.27913494 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 2
hydrogen_bond_acceptor_count: 8
rotatable_bond_count: 11
heavy_atom_count: 48
topological_polar_surface_area: 111 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Tariquidar is a member of benzamides.
chembl: TARIQUIDAR is a small molecule listed in the ChEMBL database and has reached clinical trial phase 3.0.
wikipedia: Tariquidar (INN/USAN) is a potent P-glycoprotein inhibitor and a substrate of breast cancer protein (BCRP/ABCG2) undergoing research as an adjuvant against multi-drug resistance in cancer.
Tariquidar progressed to phase III clinical trials in combination with vinorelbine in an effort to enhance the efficacy of this chemotherapeutic agent. However, several of these trials were terminated early due to adverse effects, and further development of Tariquidar was subsequently halted.