Compound: diethylcarbamazine
SMILES: O=C(N1CCN(C)CC1)N(CC)CC
InChIKey: RCKMWOKWVGPNJF-UHFFFAOYSA-N
Synonyms: diethylcarbamazine, 90-89-1, Carbamazine, N,N-Diethyl-4-methyl-1-piperazinecarboxamide, 1-Piperazinecarboxamide, N,N-diethyl-4-methyl-, Dietilcarbamazina, Diaethylcarbamazinum, Camin, Diethylcarbamazinum, V867Q8X3ZD, CHEBI:4527, DTXSID1022928, RefChem:587348, Maleate, Diethylcarbamazine, ditrazinum (for the citrate), DTXCID802928, P02CB02, Monohydrochloride, Diethylcarbamazine, 202-023-3, N,N-diethyl-4-methylpiperazine-1-carboxamide, Carbilazine, Ethodryl, Bitirazine, Notezine, Diethyl carbamazine, Ditrazine Base, Caracide, Spatonin, N,N-Diethylcarbamazine, MFCD00023288, Diethylcarbamazine (INN), 84L, Bitirazine; Caracide;Carbamazine, MMV002816, N,N-diethyl-4-methyl-piperazine-1-carboxamide, DIETHYLCARBAMAZINE [INN], Diethylcarbamazine [INN:BAN], Diethylcarbamazinum [INN-Latin], Dietilcarbamazina [INN-Spanish], NSC1364, N,N-diethyl(4-methylpiperazinyl)carboxamide, Camin (TN), EINECS 202-023-3, 1-Diethylcarbamoyl-4-Methylpiperazine, BRN 0143029, UNII-V867Q8X3ZD, AI3-19612, NN-Diethyl-4-methyl-1-piperazinecarboxamide, 1-Diethylcarbamyl-4-methylpiperazine, 1-Methyl-4-diethylcarbamoylpiperazine, Banocide (Salt/Mix), Caritrol (Salt/Mix), Nemacide (Salt/Mix), Spectrum_000938, Prestwick0_000284, Prestwick1_000284, Prestwick2_000284, Prestwick3_000284, Spectrum2_001022, Spectrum3_000390, Spectrum4_000511, Spectrum5_000877, CHEMBL684, EC 202-023-3, SCHEMBL67289, BSPBio_000188, BSPBio_002179, KBioGR_001081, KBioSS_001418, 4-23-00-00225 (Beilstein Handbook Reference), DivK1c_000548, SPBio_001203, SPBio_002407, DIETHYLCARBAMAZINE [MI], BPBio1_000208, orb1705390, KBio1_000548, KBio2_001418, KBio2_003986, KBio2_006554, KBio3_001399, NINDS_000548, HMS3604F12, DIETHYLCARBAMAZINE [WHO-DD], MSK11391, 1-Diethylcarbamoyl-4-methylpiperzine, EBC-03464, HY-12642A, SBB008185, AKOS003268016, DB00711, DS-9360, IDI1_000548, s10791, NCGC00178778-01, NCGC00178778-02, NCGC00178778-07, ST094965, SBI-0051345.P003, DB-080764, R.P. 3799, 1-(N,N-Diethylcarbamoyl)-4-methylpiperazine, AB00053457, CS-0013568, NS00000124, C07968, D07825, EN300-119374, AB00053457_12, F342019, Q409267, SR-01000759234-8, BRD-K45542189-048-05-6, BRD-K45542189-048-15-5, BRD-K45542189-048-22-1, Z641623606
Theoretical properties:
molecular_formula: C10H21N3O
molecular_weight: 199.29 g/mol
exact_mass: 199.168462302 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 2
heavy_atom_count: 14
topological_polar_surface_area: 26.8 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
melting_point: 150-155
Descriptions:
pubchem: Diethylcarbamazine is a N-carbamoylpiperazine and a N-methylpiperazine.
chembl: DIETHYLCARBAMAZINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Diethylcarbamazine is a medication used in the treatment of filariasis including lymphatic filariasis, tropical pulmonary eosinophilia, and loiasis. It may also be used for prevention of loiasis in those at high risk. While it has been used for onchocerciasis (river blindness), ivermectin is preferred. It is taken by mouth.
Common side effects include itching, facial swelling, headaches, and feeling tired. Other side effects include vision loss and dizziness. It is a recommended treatment in pregnancy and appears to be safe for the baby. The World Health Organization; however, recommends waiting until after pregnancy for treatment when feasible. It is made from 4-methyl-piperazine.
Diethylcarbamazine was discovered in 1947 by Yellapragada Subbarow. It is on the World Health Organization's List of Essential Medicines. It is not commercially available in the United States but can be acquired from the Centers for Disease Control and Prevention.