Compound: Trometamol
SMILES: OCC(N)(CO)CO
InChIKey: LENZDBCJOHFCAS-UHFFFAOYSA-N
Synonyms: Trometamol, TROMETHAMINE, 77-86-1, Tris(Hydroxymethyl)aminomethane, Tham, 2-Amino-2-(hydroxymethyl)-1,3-propanediol, Trisamine, Tris buffer, Tromethane, Tris-base, Trisaminol, Pehanorm, Talatrol, Tutofusin tris, Tris-steril, Addex-tham, Trispuffer, Trimethylolaminomethane, 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, Tris Amino, Tris, free base, Aminotrimethylolmethane, Aminotris(hydroxymethyl)methane, Tris(hydroxymethyl)methylamine, THAM-E, Tris (buffering agent), Tromethamolum, Trometamolum, 2-Amino-2-methylol-1,3-propanediol, NSC-6365, DTXSID2023723, Methanamine, 1,1,1-tris(hydroxymethyl)-, Tris-hydroxymethyl-aminomethan, 023C2WHX2V, Tris(hydroxymethyly)amino methane, NSC6365, DTXCID503723, NSC65434, Tri(hydroxymethyl)aminomethane, Tris-Mg(II)-KCl Buffer, trometamolo, RefChem:6507, B05BB03, B05XX02, 201-064-4, Tris, 2-Amino-2-(hydroxymethyl)propane-1,3-diol, Trizma, Tris base, Trisamin, Tromethanmin, Tris(hydroxymethyl)methanamine, Trometamole, Trizma base, Tris-hydroxymethylaminomethane, Tris-Amino, Methylamine, 1,1,1-tris(hydroxymethyl)-, NSC 6365, 2-(Hydroxymethyl)-2-amino-1,3-propanediol, Trometamol [INN], 2-Amino-2-hydroxymethyl-1,3-propanediol, MFCD00004679, 126850-03-1, 126850-06-4, 126850-08-6, tris(hydroxymethyl) aminomethane, Trometamol(Tris),Proteomics Grade, MFCD00132476, 1,1,1-tris(hydroxymethyl)methanamine, Trometamol(Tris),for molecular biology, NCGC00159412-02, NCGC00159412-04, Tris buffertris-hydroxymethyl-aminomethan, Triladyl, Trigmo base, M02623, WLN: Q1XZ1Q1Q, bakerbond(tm) cyano (cn), Trometamol(Tris), inverted exclamation markY99.5%, 4-Anilino-1-(2-hydroxyethylamino)anthracene-9,11-dione, Tromethamine [USAN], (tris(hydroxymethyl)aminomethane), [tris(hydroxymethyl)aminomethane], Caswell No. 036, 1, 2-amino-2-(hydroxymethyl)-, ABX (ANTIBODY EXCHANGER), TRIS(HYDROXY-D-METHYL)AMINO-D2-METHANE, 98 ATOM % D, Methanamine,1,1-tris(hydroxymethyl)-, Methylamine,1,1-tris(hydroxymethyl)-, Trometamolum [INN-Latin], tris(hydroxymethyl)amino methane, CAS-77-86-1, Tris(hydroxymethyl)aminomethane, >=99.8%, Tris(hydroxymethyl)aminomethane (Tris base), WP QUAT (STRONG ANION EXCHANGER), HSDB 3408, propane, 2-amino-1,3-dihydroxy-2-hydroxymethyl-, Tris(hydroxymethyl)aminomethane (TRIS, Trometamol), EINECS 201-064-4, Tris(hydroxymethyl)aminomethane, Electrophoresis Grade, Tromethamine [USAN:USP], EPA Pesticide Chemical Code 083901, AMINO (NH2) NARROW-PORE MEDIA-NORMAL PHASE, Tris-hydroxymethyl-aminomethan [German], UNII-023C2WHX2V, Tromethamin, Aminotri(hydroxymethyl)methane, tris-buffer, tris-amine, AI3-03948, 126850-05-3, Tro.meta.mole, Trometamol CRS, Tris(Hydroxymethyl)-Aminomethane, Tro.meta.mol, 1gng, tris base solution, THAM (Standard), 1,3-Propane-1,1,3,3-D4-diol-d2,2-(amino-d2)-2-(hydroxy-d-methyl-d2)-(9ci), Tromethamine (USP), 1h4n, Trometamol (JAN/INN), TROMETAMOL [JAN], TRS, GlyTouCan:G56296FC, TROMETHAMINE [II], TROMETHAMINE [MI], SCHEMBL975, trishydroxymethylmethylamine, THAM (TN), EC 201-064-4, TROMETHAMINE [HSDB], TROMETAMOL [MART.], NCIOpen2_000263, NCIOpen2_001720, TROMETAMOL [WHO-DD], TROMETHAMINE [VANDF], Oprea1_677781, trishydroxymethyl aminomethane, Tris(hydroxmethyl)aminomethane, tris-hydroxymethyl-methylamine, 136760-04-8, MLS000028643, SCHEMBL624804, tris hydroxymethyl aminomethane, TROMETHAMINE [USP-RS], tris-(hydroxymethyl)methylamine, Tris (hydroxymethyl)aminoethane, CHEBI:9754, GTPL7328, orb1310127, SCHEMBL1360845, SCHEMBL9166289, tris (hydroxymethyl)aminomethane, CHEMBL1200391, tris (hydroxymethyl) methylamine, HY-D0227C, HY-D0227D, HY-D0227E, HY-D0227R, tris (hydroxymethyl) aminomethane, Tris-(hydroxymethyl)-aminomethane, TROMETAMOL [EP MONOGRAPH], 2-Amino-2-hydroxymethylpropanediol, HMS3652L05, HMS3885H09, HMS5082B06, tris-(hydroxymethyl)-amino-methane, TROMETHAMINE [ORANGE BOOK], 2-amino-2-hydroxymethyl-propane-1, Tris-Base, molecular biology grade, G56296FC, HY-D0227, STR03166, THAM-E COMPONENT TROMETHAMINE, Tox21_111645, Tox21_201646, Tox21_303167, TROMETHAMINE [USP MONOGRAPH], BBL000011, EBC-02022, MSK000757, NSC-65434, s4176, SBB006714, STK379529, 1,1,1-tris(hydroxymethyl)methylamine, 2-amino-2-methylol-propane-1,3-diol, AKOS000121321, Tox21_111645_1, CCG-214012, CS-W018524, DB03754, FT15751, PB47623, Trizma(R) base, >=99.0% (T), .beta.-D-ribo-Hexopyranose, 1,6-anhydro-3-deoxy-2-O-(1-methylethyl)-4-O-(phenylmethyl)-, Tris(hydroxymethyl)aminomethane, >=99%, MSK000757-1000W, NCGC00159412-03, NCGC00159412-05, NCGC00257164-01, NCGC00259195-01, BP-13394, DA-58763, SMR000059179, Tris(hydroxymethyl)aminomethane ACS grade, Tris(hydroxymethyl)aminomethane, ultrapure, 2-amino-2-[hydroxymethyl]-1,3-propandiol, DB-091324, DS-014869, Methanamine, 1, 1,1-tris(hydroxymethyl)-, Tris acidimetric, NIST(R) SRM(R) 723e, A0321, CS-0201542, CS-0201543, CS-0201544, NS00002396, ST51037436, SW219208-1, T2516, TRIS-buffered saline (TBS, 10X) pH 7.4, TRIS-buffered saline (TBS, 10X) pH 7.6, TRIS-buffered saline (TBS, 10X) pH 8.0, TRIS-buffered saline (TBS, 20X) pH 7.4, 2-(Hydroxymethyl)-2-amino-1, 3-propanediol, 2-amino-2-(hydroxyl-methyl)propane-1,3-diol, 2-amino-2-(hydroxymethyl) propane-1,3-diol, 2-Amino-2-(hydroxymethyl)-1,3-propanediol;, EN300-21687, OmniPur TRIS -CAS 77-86-1 - Calbiochem, Trizma(R) base, BioUltra, >=99.8% (T), Tromethamine, meets USP testing specifications, C07182, D00396, P17498, SBI-0653855.0001, AB00443859_03, AB00443859_04, Q413961, Sigma 7-9(R), >=99% (titration), crystalline, SR-01000944234, Trizma(R) base, puriss. p.a., >=99.7% (T), SR-01000944234-1, Trizma(R) base, >=99.9% (titration), crystalline, Trizma(R) base, Vetec(TM) reagent grade, >=99%, BRD-K47978074-001-02-4, BRD-K47978074-001-03-2, Tris(hydroxymethyl)aminomethane, ACS reagent, 99.9%, F0001-1979, Tris(hydroxymethyl)aminomethane, ACS reagent, >=99.8%, Tris(hydroxymethyl)aminomethane, Molecular Biology Grade, TRIS-buffered saline (TBS, 10X, high salt) pH 7.4, Z104509094, Tris(hydroxymethyl)aminomethane, p.a., ACS reagent, 99.8%, Tris(hydroxymethyl)aminomethane, ultrapure grade, >=99.9%, Trizma(R) base, puriss. p.a., buffer substance, >=99.5%, Trometamol, European Pharmacopoeia (EP) Reference Standard, Tris(hydroxymethyl)aminomethane Solution in Water, 1000ug/mL, Tris(hydroxymethyl)aminomethane, JIS special grade, >=99.0%, TRIS-buffered saline (TBS, 10X) pH 7.4, for Western blot, InChI=1/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H, Trizma(R) base, anhydrous, free-flowing, Redi-Dri(TM), >=99.9%, Trizma(R) base, BioUltra, for molecular biology, >=99.8% (T), Tromethamine, United States Pharmacopeia (USP) Reference Standard, Trizma(R) base, cell culture tested, >=99.9% (titration), crystalline, Trizma(R) base, BioXtra, pH 10.5-12.0 (1 M in H2O), >=99.9% (titration), Trizma(R) base, Primary Standard and Buffer, >=99.9% (titration), crystalline, Tromethamine, Pharmaceutical Secondary Standard; Certified Reference Material, 79261-03-3, Tris-base solution, 1.5 M in water, pH 10.6 -11.2, (+/- 0.1M) contains 0.05% sodium azide added as a preservative, Trizma(R) base, BioPerformance Certified, meets EP, USP testing specifications, cell culture tested, >=99.9% (titration), Trizma(R) base, certified reference material for titrimetry, certified by BAM, according to ISO 17025, >=99.5%
Theoretical properties:
molecular_formula: C4H11NO3
molecular_weight: 121.14 g/mol
exact_mass: 121.07389321 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 4
hydrogen_bond_acceptor_count: 4
rotatable_bond_count: 3
heavy_atom_count: 8
topological_polar_surface_area: 86.7 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
physical_state: Crystalline mass
color: Crystalline mass
odor: SLIGHT, CHARACTERISTIC ODOR
boiling_point: 219-220 °C at 10 mm Hg
melting_point: 171-172 °C
solubility: 79.1 mg/mL in ethylene glycol; 26 mg/mL in methanol; 14.6 mg/mL in anhyd ethanol; 22 mg/mL in 95% ethanol; 14 mg/mL in dimethyl formamide; 20 mg/mL in acetone; 0.5 mg/mL in ethyl acetate; 0.4 mg/mL in olive oil; 0.1 mg/mL in cyclohexane; 0.05 mg/mL in chloroform; less than 0.05 mg/mL in carbon tetrachloride
vapor_pressure: 0.000022 [mmHg]
Descriptions:
{"pubchem": "Tris is a primary amino compound that is tert-butylamine in which one hydrogen attached to each methyl group is replaced by a hydroxy group. A compound widely used as a biological buffer substance in the pH range 79; pKa = 8.3 at 20 C; pKa = 7.82 at 37 C. It has a role as a buffer. It is a triol and a primary amino compound. It is a conjugate base of a member of Htris.", "chebi": "A primary amino compound that is <em>tert</em>-butylamine in which one hydrogen attached to each methyl group is replaced by a hydroxy group. A compound widely used as a biological buffer substance in the pH range 7\u20149; p<em>K</em><small><sub>a</sub></small> = 8.3 at 20 \u00b0C; p<em>K</em><small><sub>a</sub></small> = 7.82 at 37 \u00b0C.", "chembl": "TROMETHAMINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.", "wikipedia": "Tris, or tris(hydroxymethyl)aminomethane, or known during medical use as tromethamine or THAM, is an organic compound with the formula (HOCH2)3CNH2. It is extensively used in biochemistry and molecular biology as a component of buffer solutions such as in TAE and TBE buffers, especially for solutions of nucleic acids. It contains a primary amine and thus undergoes the reactions associated with typical amines, e.g., condensations with aldehydes. Tris also complexes with metal ions in solution. In medicine, tris (known as tromethamine) is occasionally used as a drug, given in intensive care for its properties as a buffer for the treatment of severe metabolic acidosis in specific circumstances. Some medications are formulated as the \"tromethamine salt\" including Hemabate (carboprost as trometamol salt), and \"ketorolac trometamol\". In 2023 a strain of Pseudomonas hunanensis was found to be able to degrade TRIS buffer.\nSince Tris' pKa is more strongly temperature dependent, its use is not recommended in biochemical applications requiring consistent pH over a range of temperatures. Moreover, the temperature dependence of the pKa (and in turn buffer solution pH) makes pH adjustment difficult. (E.g., the 'room temperature' pH adjustment would not translate to 'measurement conditions' pH, unless care is taken to calculate the effect of temperature, see below.)"}