Compound: METHAQUALONE
SMILES: O=c1n(-c2c(cccc2)C)c(nc3c1cccc3)C
InChIKey: JEYCTXHKTXCGPB-UHFFFAOYSA-N
Synonyms: METHAQUALONE, Metolquizolone, 72-44-6, Methaqualoneinone, Metaqualon, Quaalude, Tuazolone, Cateudyl, Hyminal, Melsomin, Ortonal, Dormigoa, Dormogen, Dormutil, Dorsedin, Fadormir, Holodorm, Mollinox, Mozambin, Nobedorm, Noctilene, Optinoxan, Orthonal, Parminal, Rouqualone, Sindesvel, Somberol, Somnomed, Hyptor, Ipnofil, Motolon, Roulone, Soverin, Torinal, Omnyl, Sonal, Sopor, Hyptor base, Normi-Nox, Citexal, Mequin, Melsedin base, MAOA, Rorer 148, Somnafac, 3,4-Dihydro-2-methyl-4-oxo-3-o-tolylquinazoline, Metacualona, 2-Methyl-3-(2-methylphenyl)-4(3H)-quinazolinone, CI-705, TR-495, 2-Methyl-3-o-tolyl-4(3H)-quinazolinone, R-148, 2-Methyl-3-o-tolyl-4-quinazolone, 2-Methyl-3-tolyl-4-oxybensdiazine, CN 38703, Metaqualone, Methaqualonum, Hypcol, 2-Methyl-3-(2-tolyl)quinazol-4-one, RIC 272, 2-Methyl-3-o-tolyl-4(3H)-chinazolone, 4(3H)-Quinazolinone, 2-methyl-3-(2-methylphenyl)-, 2-Methyl-3-(2-methylphenyl)-4-quinazolinone, 2-Methyl-3-o-tolyl-4(3H)-chinazolinon, 7ZKH8MQW6T, 4(3H)-Quinazolinone, 2-methyl-3-o-tolyl-, NSC-111388, NSC-126877, NSC-631628, Parest, CHEBI:6821, DTXSID7023279, TR 495, 2-methyl-3-(o-tolyl)quinazolin-4-one, CN-38703, DTXCID403279, NSC126877, (+-)-Methaqualone, RefChem:6014, N05CM01, RIC-272, 200-780-4, Metakvalon, Methaqualon, Tuazole, Aqual, Hypocol, Melsed, Revonal, Dormigoa-Schlafmittel, Pro-dorm, Rorer 714, Nethaqualone, Metachalon, QZ 2, QZ-2, 2-Methyl-3-(o-tolyl)-3,4-dihydro-4-quinazolinone, MTQ, Methaqualone-d5, 2-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one, CI 705, NSC631628, Metachalon [Czech], NCGC00245236-02, Metacualona [INN-Spanish], Methaqualonum [INN-Latin], Tuazol, CAS-72-44-6, WLN: T66 BVN ENJ CR B1& D1, HSDB 3120, EINECS 200-780-4, UNII-7ZKH8MQW6T, NSC 111388, 2-Methyl-3-o-tolyl-4(3H)-chinazolinon [German], BRN 0211874, Methaquaione, Reposil, DEA No. 2565, Methaqualone [USAN:USP:INN:BAN], 1184966-71-9, A1ADG, METHAQUALONE [MI], (.+/-.)-Methaqualone, METHAQUALONE [INN], METHAQUALONE [JAN], Epitope ID:613446, METHAQUALONE [HSDB], METHAQUALONE [USAN], METHAQUALONE [VANDF], SCHEMBL43892, METHAQUALONE [MART.], 5-24-03-00132 (Beilstein Handbook Reference), MLS000678342, METHAQUALONE [WHO-DD], CHEMBL282052, SCHEMBL29355239, SCHEMBL29386732, Methaqualone, 1mg/ml in Methanol, 4(3H)-Quinazolinone, 2-methyl-3-(2-methylphenyl)-, (-)-, HMS2626L18, METHAQUALONE [EP IMPURITY], Methaqualone 0.1 mg/ml in Methanol, Methaqualone 1.0 mg/ml in Methanol, Tox21_112502, Tox21_112869, 2-Methyl-3-o-tolylquinazolin-4-one, NSC111388, STL386501, AKOS000509786, DB04833, NSC-111388-, NCGC00245236-01, SMR000285241, 2-methyl-3-(o-tolyl)-3H-quinazolin-4-one, NS00006468, 4(3H)-Quinazolinone, 2-methyl-3-o--tolyl-, C07560, D00557, 2-methyl-3-(o-tolyl)-quinazoline-4 (3H)-one, Q423912, (2-Methyl-3-(o-tolyl)-3,4-dihydro-4-(quinazolinone), MQL
Theoretical properties:
molecular_formula: C16H14N2O
molecular_weight: 250.29 g/mol
exact_mass: 250.110613074 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 1
heavy_atom_count: 19
topological_polar_surface_area: 32.7 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
physical_state: CRYSTALS
color: CRYSTALS
odor: LITTLE OR NO ODOR
solubility: PRACTICALLY INSOL IN WATER
Descriptions:
pubchem: Methaqualone is a member of the class of quinazolines that is quinazolin-4-one substituted at positions 2 and 3 by methyl and o-tolyl groups respectively. A depressant that increases the activity of the GABA receptors in the brain and nervous system, it is used as a sedative and hypnotic medication. It became popular as a recreational drug and club drug in the late 1960s and 1970s. It has a role as a sedative and a GABA agonist.
chebi: A member of the class of quinazolines that is quinazolin-4-one substituted at positions 2 and 3 by methyl and  <em>o</em>-tolyl groups respectively. A depressant that increases the activity of the GABA receptors in the brain and nervous system, it is used as a sedative and hypnotic medication. It became popular as a recreational drug and club drug in the late 1960s and 1970s.
chembl: METHAQUALONE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Methaqualone is a sedative-hypnotic medication that was widely prescribed during the mid-20th century. It was marketed under various brand names, including Quaalude ( KWAY-lood) and Sopor, typically containing 300 mg of methaqualone per tablet. A combination drug known as Mandrax was sold primarily in Europe, containing 250 mg of methaqualone and 20 mg of diphenhydramine in a single tablet.
Methaqualone belongs to the quinazolinone class of compounds. Its commercial production was discontinued in many countries during the mid-1980s due to widespread misuse, addiction, and associated public health concerns.