Compound: dopamine
SMILES: Oc1c(O)ccc(c1)CCN
InChIKey: VYFYYTLLBUKUHU-UHFFFAOYSA-N
Synonyms: dopamine, 4-(2-Aminoethyl)benzene-1,2-diol, 51-61-6, 3-Hydroxytyramine, Oxytyramine, Hydroxytyramin, Dopamin, 3,4-dihydroxyphenethylamine, 4-(2-Aminoethyl)catechol, 4-(2-Aminoethyl)pyrocatechol, hydroxytyramine, 2-(3,4-dihydroxyphenyl)ethylamine, Dopamina, Dopaminum, 3,4-Dihydroxyphenylethylamine, 4-(2-Aminoethyl)-1,2-benzenediol, ASL 279, 1,2-Benzenediol, 4-(2-aminoethyl)-, Dobutamine a, A-dopamine, alpha-(3,4-Dihydroxyphenyl)-beta-aminoethane, Revivan, VTD58H1Z2X, NSC-173182, DTXSID6022420, DTXCID602420, CHEBI:18243, 3,4 Dihydroxyphenethylamine, Dopamine 1515, RefChem:6423, 200-110-0, Medopa, Dophamine, intropin, L-DOPAMINE, Pyrocatechol, 4-(2-aminoethyl)-, Dopaminum [INN-Latin], Dopamina [INN-Spanish], 3-Hydroxtyramine, KW-3-060, 4-(2-aminoethyl)-pyrocatechol, MFCD00130258, Dopamine (INN), Dynatra, NSC 173182, a-(3,4-Dihydroxyphenyl)-b-aminoethane, 4-(2-Aminoethyl)-1,2-bezenediol, 50444-17-2, Revimine, LDP, NCGC00015519-05, Pyrocatechol, 4-(2-aminoethyl)- (8CI), DOPAMINE [INN], Dopamine [INN:BAN], .alpha.-(3,4-Dihydroxyphenyl)-.beta.-aminoethane, (3H)-Dopamine, Pyrocatechol, 4-(2-aminoethyl)-, hydrochloride, 62-31-7 (HYDROCHLORIDE), CAS-51-61-6, Medopa (TN), NSC169105, HSDB 3068, 1,2-Benzenediol, 4-(2-aminoethyl)- (9CI), 4-(2-Aminoethyl)-1,2-benzenediol hydrochloride, EINECS 200-110-0, UNII-VTD58H1Z2X, Intropin [*hydrochloride*], SR-01000075366, .beta.-(3,4-Dihydroxyphenyl)ethylamine hydrochloride, m-Hydroxytyramine-, Dopamine (USAN)(*hydrochloride*), IP 498, Intropin (Salt/Mix), Spectrum_001012, 1,2-Benzenediol, 4-(2-aminoethyl)-, labeled with tritium, DOPAMINE [HSDB], DOPAMINE [MI], CHEMBL59, DOPAMINE [VANDF], Spectrum2_001023, Spectrum3_000406, Spectrum4_000525, Spectrum5_000945, Lopac-H-8502, Biomol-NT_000001, bmse000909, bmse000933, DOPAMINE [WHO-DD], SCHEMBL8505, 1, 4-(2-aminoethyl)-, Lopac0_000586, Oprea1_088821, BSPBio_001932, GTPL940, KBioGR_001129, KBioGR_002388, KBioGR_002484, KBioSS_001492, KBioSS_002393, KBioSS_002491, cid_65340, BIDD:ER0506, DivK1c_000780, SPECTRUM1505155, 62-31-7(HCl salt), SPBio_001205, BPBio1_001123, 153C5321-5FEE-4B0B-8925-F388F0EEEBD1, SCHEMBL10383031, SCHEMBL28165888, SCHEMBL29362033, BDBM55121, KBio1_000780, KBio2_001492, KBio2_002388, KBio2_002484, KBio2_004060, KBio2_004956, KBio2_005052, KBio2_006628, KBio2_007524, KBio2_007620, KBio3_001152, KBio3_002867, KBio3_002962, cMAP_000036, cMAP_000065, NINDS_000780, HMS3743I03, 4-(2-Aminoethyl)benzene-12-diol, Tox21_110167, 2-(3, 4-Dihydroxyphenyl)ethylamine, 2-(3,4-dihydroxyphenyl) ethylamine, BBL013043, EBC-26106, SBB004044, STK301601, 3,4-DihydroxyphenylA currencythylamin, AKOS003790978, Tox21_110167_1, CCG-204675, DB00988, FS-5341, MSK000570-100M, SDCCGSBI-0050568.P005, 2-(3,4-Dihydroxyphenyl)-1-ethanamine, 4-(2-Amino-ethyl)-benzene-1,2-diol, 4-(2-Aminoethyl)-1,2-benzenediol #, IDI1_000780, UPCMLD0ENAT5885989:001, NCGC00015519-01, NCGC00015519-02, NCGC00015519-03, NCGC00015519-04, NCGC00015519-07, NCGC00015519-08, NCGC00015519-09, NCGC00015519-10, NCGC00015519-11, NCGC00015519-13, NCGC00015519-25, NCGC00096050-01, NCGC00096050-02, NCGC00096050-03, NCGC00096050-04, NCGC00096050-05, BP-23276, Dopamine Solution in Methanol, 100ug/mL, ST048774, 4-(2-aminoethyl)pyrocatechol;hydrochloride, SBI-0050568.P004, benzene, 1-(2-amino)ethyl-3,4-dihydroxy-, NS00000608, EN300-35022, C03758, D07870, F21485, 4-(2-azanylethyl)benzene-1,2-diol;hydrochloride, AB00053463-12, AB00053463_13, AB00053463_14, F221308, L000232, Q170304, SR-01000075366-7, BRD-K43887077-003-25-5, BRD-K43887077-003-26-3, BRD-K43887077-003-27-1, NORADRENALINE TARTRATE IMPURITY C [EP IMPURITY], DOBUTAMINE HYDROCHLORIDE IMPURITY A [EP IMPURITY], DOBUTAMINE HYDROCHLORIDESPECIFIED IMPURITY A [EP IMPURITY], Noradrenaline (Norepinephrine) EP Impurity C; Dopamine; Dobutamine EP Impurity A, 86389-83-5
Theoretical properties:
molecular_formula: C8H11NO2
molecular_weight: 153.18 g/mol
exact_mass: 153.078978594 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 3
hydrogen_bond_acceptor_count: 3
rotatable_bond_count: 2
heavy_atom_count: 11
topological_polar_surface_area: 66.5 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
physical_state: Stout prisms
color: Stout prisms
Descriptions:
{"pubchem": "Dopamine is catechol in which the hydrogen at position 4 is substituted by a 2-aminoethyl group. It has a role as a beta-adrenergic agonist, a sympathomimetic agent, a cardiotonic drug, a dopaminergic agent, a mouse metabolite, an Escherichia coli metabolite and a human metabolite. It is a conjugate base of a dopaminium(1+).", "chebi": "Catechol in which the hydrogen at position 4 is substituted by a 2-aminoethyl group.", "chembl": "DOPAMINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.", "wikipedia": "Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is a neuromodulatory molecule that plays several important roles in cells. It is an organic chemical of the catecholamine and phenethylamine families. It is an amine synthesized by removing a carboxyl group from a molecule of its precursor chemical, L-DOPA, which is synthesized in the brain and kidneys. Dopamine is also synthesized in plants and most animals. In the brain, dopamine functions as a neurotransmitter\u2014a chemical released by neurons (nerve cells) to send signals to other nerve cells. The brain includes several distinct dopamine pathways, one of which plays a major role in the motivational component of reward-motivated behavior. The anticipation of most types of rewards increases the level of dopamine in the brain, and many addictive drugs increase dopamine release or block its reuptake into neurons following release. Other brain dopamine pathways are involved in motor control and in controlling the release of various hormones. These pathways and cell groups form a dopamine system which is neuromodulatory.\nIn popular culture and media, dopamine is often portrayed as the main chemical of pleasure, but the current opinion in pharmacology is that dopamine instead confers motivational salience; in other words, dopamine signals the perceived motivational prominence (i.e., the desirability or aversiveness) of an outcome, which in turn propels the organism's behavior toward or away from achieving that outcome.\nOutside the central nervous system, dopamine functions primarily as a local paracrine messenger. In blood vessels, it inhibits norepinephrine release and acts as a vasodilator; in the kidneys, it increases sodium excretion and urine output; in the pancreas, it reduces insulin production; in the digestive system, it reduces gastrointestinal motility and protects intestinal mucosa; and in the immune system, it reduces the activity of lymphocytes. With the exception of the blood vessels, dopamine in each of these peripheral systems is synthesized locally and exerts its effects near the cells that release it.\nSeveral important diseases of the nervous system are associated with dysfunctions of the dopamine system, and some of the key medications used to treat them work by altering the effects of dopamine. Parkinson's disease, a degenerative condition causing tremor and motor impairment, is caused by a loss of dopamine-secreting neurons in an area of the midbrain called the substantia nigra. Its metabolic precursor L-DOPA can be manufactured; Levodopa, a pure form of L-DOPA, is the most widely used treatment for Parkinson's. There is evidence that schizophrenia involves altered levels of dopamine activity, and most antipsychotic drugs used to treat this are dopamine antagonists which reduce dopamine activity. Similar dopamine antagonist drugs are also some of the most effective anti-nausea agents. Restless legs syndrome and attention deficit hyperactivity disorder (ADHD) are associated with decreased dopamine activity. Dopaminergic stimulants can be addictive in high doses, but some are used at lower doses to treat ADHD. Dopamine itself is available as a manufactured medication for intravenous injection. It is useful in the treatment of severe heart failure or cardiogenic shock. In newborn babies it may be used for hypotension and septic shock.\n\n"}