Compound: Dimetacrine
SMILES: N1(c2c(cccc2)C(C)(C)c3c1cccc3)CCCN(C)C
InChIKey: RYQOGSFEJBUZBX-UHFFFAOYSA-N
Synonyms: Dimetacrine, Dimethacrine, 4757-55-5, Dimethacrin, Dimetacrinum, Dimetacrina, 9,9-Dimethyl-10-(3-(dimethylamino)propyl)acridan, NSC-100297, N,N,9,9-Tetramethyl-10(9H)-acridinepropanamine, DTXSID4022941, O341NY501N, DTXCID602941, 3-(9,9-Dimethyl-10(9H)-acridinyl)-N,N-dimethyl-1-propanamine, dimetacrine tartate, RefChem:134163, N06AA18, (3-(9,9-dimethyl-9,10-dihydroacridin-10-yl)propyl)dimethylamine, 10-(3-(dimethylamino)propyl)-9,9-dimethylacridan tartrate, Dimetacrino, Dimetacrine [INN], 3-(9,9-dimethylacridin-10-yl)-N,N-dimethylpropan-1-amine, NSC 100297, 3-(9,9-dimethylacridin-10(9H)-yl)-N,N-dimethylpropan-1-amine, NSC100297, 10-(3-(Dimethylamino)propyl)-9,9-dimethylacridan, 10(9H)-Acridinepropanamine, N,N,9,9-tetramethyl-, Acridan, 10-(3-(dimethylamino)propyl)-9,9-dimethyl-, 10-[3-(Dimethylamino)propyl]-9,9-dimethylacridan, Dimetacrine (INN), Dimethacine, Dimethacin, ACRIDAN, 9,9-DIMETHYL-10-(3-(DIMETHYLAMINO)PROPYL)-, Dimetacrina [DCIT], Dimetacrinum [INN-Latin], Dimetacrino [INN-Spanish], BRN 1349663, Dimetacrin, UNII-O341NY501N, DIMETACRINE [MI], DIMETACRINE [JAN], NCIStruc1_000731, NCIStruc2_000432, Oprea1_290546, SCHEMBL50120, DIMETACRINE [WHO-DD], 5-20-08-00134 (Beilstein Handbook Reference), orb1707375, CHEMBL1328913, SCHEMBL29578094, CHEBI:135233, RYQOGSFEJBUZBX-UHFFFAOYSA-N, 9,9-Dimethyl-10-(3-dimethylaminopropyl)-9,10-dihydroacridin, GLXC-03859, EAA75755, HY-B2075, Tox21_110043, 9,9-Dimethyl-10-(3-dimethylaminopropyl)-9,10-dihydroacridin [IUPAC], CCG-36282, NCGC00014044, NCI100297, AKOS040741644, DB08996, NCGC00014044-01, NCGC00014044-02, NCGC00097153-01, DA-72784, NCI60_000010, XS170777, CAS-4757-55-5, CS-0017455, NS00006930, D02565, N,9,9-Tetramethyl-10(9H)-acridinepropanamine, 10(9H)-Acridinepropanamine,N,9,9-tetramethyl-, WLN: T C666 BN IHJ B3N1&1 I1 I1, Q5277302, 3-(9,9-dimethylacridin-10-yl)-N,N-dimethyl-propan-1-amine, 3-(9,9-Dimethyl-10(9H)-acridinyl)-N,N-dimethyl-1-propanamine #, 94279-99-9
Theoretical properties:
molecular_formula: C20H26N2
molecular_weight: 294.4 g/mol
exact_mass: 294.209598838 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 4
heavy_atom_count: 22
topological_polar_surface_area: 6.5 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
melting_point: 155-156
Descriptions:
pubchem: Dimetacrine is a member of acridines.
chembl: DIMETACRINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 2.0.
wikipedia: Dimetacrine (also known as dimethacrine and acripramine; brand names Istonil, Istonyl, Linostil, and Miroistonil) is a tricyclic antidepressant (TCA) used in Europe and formerly in Japan for the treatment of depression. It has imipramine-like effects; though, in a double-blind clinical trial against imipramine, dimetacrine was found to have lower efficacy in comparison and produced more weight loss and abnormal liver tests. 
Little is known about the pharmacology of dimetacrine, but it can be inferred that it acts in a similar manner to other TCAs. If this is indeed the case, dimetacrine may induce severe cardiac toxicity in overdose (a side effect unique to the tricyclic class of antidepressants).