Compound: Nikethamide
SMILES: O=C(N(CC)CC)c1cnccc1
InChIKey: NCYVXEGFNDZQCU-UHFFFAOYSA-N
Synonyms: Nikethamide, N,N-DIETHYLNICOTINAMIDE, 59-26-7, Nicethamide, Nikethyl, Niquetamida, N,N-diethylpyridine-3-carboxamide, Nicethamidum, Carditonic, Diaethylamidum acidi nicotinici, NSC-130820, DTXSID9046524, 368IVD6M32, DTXCID7026524, Corethamid, Nizethamid, Diethylnicotinamid, Nicotinic Diethylamide, NIKETHAMIDUM, Diethylamide, Nicotinic, RefChem:854147, R07AB02, 200-418-5, Anacardone, Coramine, 3-Pyridinecarboxamide, N,N-diethyl-, Carbamidal, Corvotone, Nicorine, Pyricardyl, Corvin, Niamine, Anacordone, Astrocar, Cardamine, Cardiamid, Cardimon, Cordiamin, Corediol, Corvitol, Dynacoryl, Inicardio, Nicetamide, Nikardin, Stimulin, Ventramine, Coracon, Cormed, Cormid, Eucoran, Nikorin, Camphozone, Canfodiamina, Cardiamide, Cardiamina, Cardiamine, Coraetamidum, Coraethamide, Coraethamidum, Cordiamine, Corethamide, Dynamicarde, Nicordamin, Nicotinic acid diethylamide, Niketamide, Niketharol, Niketilamid, Procardine, Salvacorin, Stellamine, Cardiagen, Citocor, Coralept, Coravita, Corazone, Cordiamid, Corditon, Cordynil, Corespin, Coretone, Cormotyl, Cornotone, Corotonin, Corovit, Corvitan, Corywas, Danamine, Dinacoryl, Elitone, Hansacor, Kardiamid, Kardonyl, Kordiamin, Leptamin, Mediamid, Nicoryl, Niketamid, Percoral, Procorman, Reformin, Rehormin, Salvacard, Sancora, Solyacord, Stiminol, Tonocor, Corivo, Nicor, Diethylnicotinamide, Diethyl-Nicotamide, Nisetamide, Dietilamide-Carbopiridina, Diaethyl-nicotinamid, Pyridine-3-carboxydiethylamide, N,N-Diethyl-3-pyridinecarboxamide, Vasazol, Pyridine-3-carboxylic acid diethylamide, .beta.-Pyrimidum, Nicotinamide, N,N-diethyl-, Ni-Cor, MFCD00006386, Diethylamid kyseliny nikotinove, Nikethamide (INN), NCGC00166026-01, Nicaethamidum, Nicotinamide,N-diethyl-, beta-Pyrimidum, NIKETHAMIDE [INN], WLN: T6NJ CVN2&2, Nicetamide [DCIT], 3-Pyridinecarboxamide,N-diethyl-, N,N-diethyl-3-pyridylcarboxamide, Nicetamida, Coramin, N,N-Diethylnicotinamide (Nikethamide), Nicetamida [INN-Spanish], Nicethamidum [INN-Latin], Diaethyl-nicotinamid [German], EINECS 200-418-5, NSC 130820, Diethylamid kyseliny nikotinove [Czech], BRN 0005743, Nickethamide, Niketamine, Nikethamide [INN:BAN:NF], Ecoran, UNII-368IVD6M32, AI3-01438, Coractiv N, Nikethamide CRS, Carditonic (TN), NN-Diethylnicotinamide, Nikethamide (Standard), N,N-diethyl nicotinamide, NIKETHAMIDE [MI], NIKETHAMIDE [MART.], NIKETHAMIDE [WHO-DD], MLS004773905, SCHEMBL246456, N,N-Diethylnicotinamide, 99%, orb2281212, SCHEMBL4818530, CHEMBL2104607, SCHEMBL23036843, SCHEMBL29754232, HY-B1280R, 3-(N,N-Diethylcarbamoyl)pyridine, CHEBI:134814, HMS3264D18, HMS3886G05, HMS5083N20, NIKETHAMIDE [EP MONOGRAPH], Pharmakon1600-01506157, HY-B1280, MSK10210, Tox21_112295, BDBM50248014, EBC-03427, NSC-62103, NSC760377, s4887, SBB056987, AKOS003607578, CCG-213619, DB13655, FD31942, MB00187, NSC-169863, NSC-760377, CAS-59-26-7, NCGC00166026-02, AC-12043, AC-31724, AS-48195, SMR000059067, DB-053354, D0514, NS00008862, ST50308250, D07408, F19704, AB01563149_01, EN300-6492955, Q902548, SR-01000939653, SR-01000939653-2, BRD-K91544578-001-03-8, Z31723199, Nikethamide, European Pharmacopoeia (EP) Reference Standard, InChI=1/C10H14N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H
Theoretical properties:
molecular_formula: C10H14N2O
molecular_weight: 178.23 g/mol
exact_mass: 178.110613074 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 3
heavy_atom_count: 13
topological_polar_surface_area: 33.2 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
boiling_point: 565 to 572 °F at 760 mmHg (some decomposition) (NTP, 1992)
melting_point: 75 to 79 °F (NTP, 1992)
density: 1.058 to 1.066 at 77 °F (NTP, 1992)
solubility: greater than or equal to 100 mg/mL at 73 °F (NTP, 1992)
flash_point: 235 °F (NTP, 1992)
Descriptions:
pubchem: Nikethamide is a pyridinecarboxamide. It is functionally related to a nicotinamide.
chembl: NIKETHAMIDE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 2.0.
wikipedia: Nikethamide is a stimulant which mainly affects the respiratory cycle. Widely known by its former trade name of Coramine, it was used in the mid-twentieth century as a medical countermeasure against tranquilizer overdoses, before the advent of endotracheal intubation and positive-pressure lung expansion. It is no longer commonly considered to be of value for such purposes.
In alternate terminology, it is known as nicotinic acid diethylamide, which meaningfully emphasizes its laboratory origins, and of which its common name is derived as a blend.