Compound: Pentetrazol
SMILES: n1nn2CCCCCc2n1
InChIKey: CWRVKFFCRWGWCS-UHFFFAOYSA-N
Synonyms: Pentetrazol, PENTYLENETETRAZOLE, Pentylenetetrazol, 54-95-5, Metrazole, 1,5-Pentamethylenetetrazole, Cardiol, Cardiazole, Coranormol, Cenazol, Korazol, Leptazol, Corazole, Coryvet, Korazole, Leptazole, Pentetrazole, Corvasol, Deumacard, Phrenazol, Ventrazol, Corazol, Gewazol, Pentamethylenetetrazole, Cardifortan, Cardiotonicum, Coratoline, Corsedrol, Diovascole, Kardiazol, Pentrazol, Pentrolone, Angiazol, Cardosal, Cardosan, Corisan, Tetracor, Tetrazol, Yetrazol, Cortis, Coranormal, Deamocard, Nauranzol, Neocardol, Pemetesan, Penetrasol, Pentacard, Pentemesan, Pentrozol, Opticor, Vasorex, Cerebro-nicin, 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine, Cenalene-M, Pentamethylenetetrazol, Corazole (analeptic), Pentamethylene-1,5-tetrazole, Pentetrazolum, Corazolum, Pentetrazolo, Cardiozol, alpha,beta-Cyclopentamethylenetetrazole, Tetrazole, (1,5-pentanediyl)-, 6,7,8,9-Tetrahydro-5-azepotetrazole, 6,7,8,9-Tetrahydro-5H-tetrazoloazepine, 5H-Tetrazolo[1,5-a]azepine, 6,7,8,9-tetrahydro-, NSC-5729, NSC-66489, WM5Z385K7T, 1,2,3,3a-Tetrazacyclohepta-8a,2-cyclopentadiene, DTXSID7041091, 6,7,8,9-Tetrahydro-5H-tetrazolo(1,5-a)azepine, 5H-Tetrazolo(1,5-a)azepine, 6,7,8,9-tetrahydro-, 7,8,9,10-Tetrazabicyclo(5.3.0)-8,10-decadiene, DTXCID5021091, CHEBI:34910, 7,8,9,10-Tetrazabicyclo[5.3.0]-8,10-decadiene, RefChem:928805, R07AB03, 200-219-3, Cardiazol, Metrazol, Pentazol, Pentamethazol, Corasol, Pentamethazolum, Centrazole, Naurazol, Nedcardol, Neurazol, Pentazolum, Petrazole, Phrenazone, Corvis, Novo cora-vinco, Metalex-P, Delzol-W, Tetrazole, pentamethylene-, TT87, Penetratsol, Stellacardiol, Stillcardiol, Angioton, Lepazol, Penetiazol, Pentacor, Petazol, Petezol, PTZ, Pentametilentetrazolo, Pentetrazol [INN], Su-Zol, Pentamethylenetetrazal, MFCD00005939, .alpha.,.beta.-Cyclopentamethylenetetrazole, NSC5729, NSC66489, Pentetrazol (INN), CAS-54-95-5, NCGC00015827-06, Pentetratsol, Pentrazole, Tetrazole,5-pentanediyl)-, WLN: T57 ANNNN&TJ, PMT, Pentetrazolo [DCIT], 6,8,9-Tetrahydro-5-azepotetrazole, Cenalene M, Delzol W, 6,8,9-Tetrahydro-5H-tetrazoloazepine, Pentetrazolum [INN-Latin], 5H-Tetrazoloazepine,7,8,9-tetrahydro-, 5H-Tetrazolo[1, 6,7,8,9-tetrahydro-, Pentametilentetrazolo [Italian], 1,3,3a-Tetrazacyclohepta-8a,2-cyclopentadiene, Pentylenetetrazol [NF], 7,9,10-Tetrazabicyclo[5.3.0]-8,10-decadiene, SR-01000076073, NSC 5729, EINECS 200-219-3, NSC 66489, BRN 0135492, UNII-WM5Z385K7T, Pentavet, 5H,6H,7H,8H,9H-1,2,3,4-tetraazolo[1,5-a]azaperhydroepine, pentylentetrazole, AI3-23994, Prestwick_382, Pentamethylene tetrazole, Spectrum_000393, SpecPlus_000787, 5H-Tetrazoloazepine, 6,7,8,9-tetrahydro-, Prestwick0_000162, Prestwick1_000162, Prestwick2_000162, Prestwick3_000162, Spectrum2_001121, Spectrum3_001408, Spectrum4_000242, Spectrum5_001338, Lopac-P-6500, Biomol-NT_000269, Coryvet [veterinary] (TN), PENTETRAZOL [MART.], Lopac0_000940, SCHEMBL22674, 1, 5-Pentamethylenetetrazole, 1,5-pentamethylene tetrazole, BSPBio_000023, BSPBio_003056, KBioGR_000644, KBioSS_000873, PENTETRAZOL [WHO-DD], 4-26-00-01713 (Beilstein Handbook Reference), DivK1c_006883, SPECTRUM2300347, SPBio_000981, SPBio_001944, PENTYLENETETRAZOLE [MI], BPBio1_000027, BPBio1_000860, CHEMBL116943, orb2281210, KBio1_001827, KBio2_000873, KBio2_003441, KBio2_006009, KBio3_002276, PENTYLENETETRAZOL [VANDF], HMS1568B05, HMS2093P18, HMS2095B05, HMS3262L22, HMS3269N13, HMS3414P17, HMS3678P15, HMS3712B05, HMS3885P08, HMS5083B17, Pharmakon1600-02300347, HY-B1242, MSK10939, Tox21_110234, Tox21_500940, CCG-40268, HB0481, NSC759592, s4587, SBB058174, STL356056, AKOS005207166, CS-4890, DB13415, FP26833, LP00940, NSC-759592, SB17494, SDCCGSBI-0050914.P004, NCGC00015827-01, NCGC00015827-02, NCGC00015827-03, NCGC00015827-04, NCGC00015827-05, NCGC00015827-07, NCGC00015827-08, NCGC00015827-09, NCGC00015827-17, NCGC00094246-01, NCGC00094246-02, NCGC00094246-03, NCGC00094246-04, NCGC00094246-05, NCGC00261625-01, AS-47604, 6,7,8, 9-Tetrahydro-5H-tetrazoloazepine, SBI-0050914.P003, AB00052439, EU-0100940, NS00003740, P0046, ST51015107, 5H-Tetrazoloazepine, 6,7,8, 9-tetrahydro-, D07409, F14615, AB00052439_04, Q412391, 1,2,3, 3a-Tetrazacyclohepta-8a,2-cyclopentadiene, 6,7,8,9-Tetrahydro-5H-tetraazolo[1,5-a]azepine, SR-01000076073-1, SR-01000076073-3, SR-01000076073-5, 6,7,8,9-Tetrahydro-5H-tetraazolo[1,5-a]azepine #, 7,8,9,10-Tetrazabicyclo[5.3.0]deca-8,10-diene, BRD-K57718010-001-01-0, BRD-K57718010-001-08-5, BRD-K57718010-001-10-1, BRD-K57718010-001-11-9, BRD-K57718010-001-12-7, {5H-Tetrazolo[1,5-a]azepine,} 6,7,8,9-tetrahydro-, 7,8,9, {10-Tetrazabicyclo[5.3.0]-8,10-decadiene}, 20192-24-9
Theoretical properties:
molecular_formula: C6H10N4
molecular_weight: 138.17 g/mol
exact_mass: 138.090546336 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 3
rotatable_bond_count: 0
heavy_atom_count: 10
topological_polar_surface_area: 43.6 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
melting_point: 135 to 136 °F (NTP, 1992)
solubility: greater than or equal to 100 mg/mL at 70 °F (NTP, 1992)
Descriptions:
pubchem: Pentetrazol is an organic heterobicyclic compound that is 1H-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis. It is an organic heterobicyclic compound and an organonitrogen heterocyclic compound.
chebi: An organic heterobicyclic compound that is 1<em>H</em>-tetrazole in which the hydrogens at positions 1 and 5 are replaced by a pentane-1,5-diyl group. A central and respiratory stimulant, it was formerly used for the treatment of cough and other respiratory tract disorders, cardiovascular disorders including hypotension, and pruritis.
chembl: PENTYLENETETRAZOL is a small molecule listed in the ChEMBL database and has reached clinical trial phase 2.0.
wikipedia: Pentylenetetrazol (PTZ), also known as pentylenetetrazole, pentetrazol (INN), and pentamethylenetetrazol, is a drug formerly used as a circulatory and respiratory stimulant. High doses cause convulsions, as discovered by Hungarian-American neurologist and psychiatrist Ladislas J. Meduna in 1934. It has been used in convulsive therapy, and was found to be effective in treating depression, but side effects, such as uncontrolled seizures, were difficult to avoid. In 1939, pentylenetetrazol was replaced by electroconvulsive therapy, which is easier to administer, as the preferred method for inducing seizures in England's mental hospitals. In the US, pentylenetetrazol's approval by the Food and Drug Administration (FDA) was revoked in 1982. It is used in Italy as a cardio-respiratory stimulant in combination with dihydrocodeine in a cough suppressant drug.