Compound: nortriptyline
SMILES: N(CCC=C1c2c(cccc2)CCc3c1cccc3)C
InChIKey: PHVGLTMQBUFIQQ-UHFFFAOYSA-N
Synonyms: nortriptyline, 72-69-5, Noramitriptyline, Desitriptilina, Ateben, Avantyl, Lumbeck, Desmethylamitriptyline, Noritren, Sensaval, Demethylamitriptyline, Sesaval, Demethylamitryptyline, Nortryptiline, Nortryptyline, Nortriptilina, Nortriptylinum, Psychostyl, Nortrilen, Amitryptyline, demethyl-, BL03SY4LXB, NSC-757234, 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N-methyl-, 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine, 5-(3-Methylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene, N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine, 5-(3-(Methylamino)propylidene)dibenzo(a,e)cyclohepta(1,5)diene, NCI-169453, 5-(alpha-Methylaminopropylidene)dibenzo(a,d)cyclohepta(1,4)diene, N-Methyl-3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yliden)propylamin, 10,11-Dihydro-5-(3-methylaminopropylidene)-5H-dibenzo(a,d)(1,4)cycloheptene, 10,11-Dihydro-N-methyl-5H-dibenzo(a,d)cycloheptene-delta(5,gamma)-propylamine, 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-amine, CHEBI:7640, DTXSID9023384, 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-, 5H-Dibenzo(a,d)cycloheptene-delta(sup 5),gamma-propylamine, 10,11-dihydro-N-methyl-, Desitriptyline, Desmethylamitriptylin, 10,11-dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-Delta(5,gamma)-propylamine, 3-(10,11-DIHYDRO-5H-DIBENZO(A,D)(7)ANNULEN-5-YLIDENE)-N-METHYLPROPAN-1-AMINE, methyl({3-[(2E)-tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene]propyl})amine, 5-[3-(Methylamino)propylidene]dibenzo[a,E]cyclohepta[1,5]diene, Nu Nortriptyline, Apo Nortriptyline, Gen Nortriptyline, 10,11-Dihydro-5-(3-methylaminopropylidene)-5H-dibenzo[a,d][1,4]cycloheptene, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N-methyl-1-propanamine, Novo Nortriptyline, PMS Nortriptyline, ratio Nortriptyline, methyl((3-((2E)-tricyclo(9.4.0.0^(3,8))pentadeca-1(11),3(8),4,6,12,14-hexaen-2-ylidene)propyl))amine, methyl((3-((2E)-tricyclo(9.4.0.0^(3,8))pentadeca-1(11),3,5,7,12,14-hexaen-2-ylidene)propyl))amine, methyl({3-[(2E)-tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-2-ylidene]propyl})amine, N-methyl-3-(2-tricyclo(9.4.0.03,8)pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine, RefChem:55735, DTXCID903384, N06AA10, 3-(5,6-dihydrodibenzo(2,1-b:2',1'-f)(7)annulen-11-ylidene)-N-methylpropan-1-amine, 200-788-8, methyl(3-(tricyclo(9.4.0.03,8)pentadeca-1(15),3,5,7,11,13-hexaen-2-ylidene)propyl)amine, Aventyl, Aventyl;Desitriptilina, Nortriptyline (INN), Pamelor hydrochloride, Nortriptylene hydrochloride, 3-(10,11-Dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N-methylpropylamine, MFCD00242775, Nortriptilina [DCIT], NORTRIPTYLINE [INN], Nortriptyline [INN:BAN], Demethylamitriptylene, Nortriptylinum [INN-Latin], Amitriptyline EP Impurity C, 3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methyl-1-propanamine, Nortrilen (TN), CCRIS 9175, CAS-894-71-3, EINECS 200-788-8, UNII-BL03SY4LXB, BRN 2216786, nortriptylina, HSDB 3371, Triptyline-M nor, 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methylpropylamine, NCI169453, Spectrum_001041, Psychostyl (Salt/Mix), Prestwick0_000254, Prestwick1_000254, Prestwick2_000254, Prestwick3_000254, Spectrum2_000997, Spectrum3_000526, Spectrum4_000455, Spectrum5_001377, Lopac-N-7261, NORTRIPTYLINE [MI], CHEMBL445, NCIStruc1_000856, NCIStruc2_000700, NCIOpen2_004361, BIDD:PXR0187, Lopac0_000868, SCHEMBL34527, BSPBio_000068, BSPBio_002111, KBioGR_000870, KBioSS_001521, NORTRIPTYLINE [VANDF], DivK1c_000151, SPECTRUM1500442, SPBio_001093, SPBio_002287, NORTRIPTYLINE [WHO-DD], BPBio1_000076, GTPL2404, orb1983412, SCHEMBL29362430, HMS500H13, KBio1_000151, KBio2_001521, KBio2_004089, KBio2_006657, KBio3_001611, NINDS_000151, BDBM112777, HMS1920B20, HMS2091J20, KUC112478N, Pharmakon1600-01500442, CCG-38266, EBC-26367, NCGC00014483, NSC757234, PDSP1_001805, PDSP2_001788, DB00540, FN28876, NSC 757234, SDCCGSBI-0050843.P006, (2)10,11-Dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-.delta.5.gamma.-propylamine, IDI1_000151, MRF-0000480, QTL1_000063, NCGC00014483-02, NCGC00014483-03, NCGC00014483-04, NCGC00014483-05, NCGC00014483-06, NCGC00014483-07, NCGC00014483-08, NCGC00014483-09, NCGC00014483-10, NCGC00014483-11, NCGC00014483-12, NCGC00014483-14, NCGC00014483-16, NCGC00014483-23, NCGC00024261-03, NCGC00024261-04, NCGC00024261-05, NCGC00024261-06, DA-56264, KSC-315-028-, MS-23718, NCI60_001354, SY278821, SBI-0050843.P004, US8629135, SW-02, DB-240489, HY-118620, AB00052061, CS-0067638, NS00010393, EN300-57709, C07274, D08288, F82279, Q61387, AB00052061_16, F610083, SR-01000000223-4, BRD-K91263825-003-03-2, BRD-K91263825-003-21-4, AMITRIPTYLINE HYDROCHLORIDE IMPURITY C [EP IMPURITY], 1-propanamine,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-, 10,11-Dihydro-N-methyl-5H-dibenzo(a,d)cycloheptane-.DELTA.,.gamma.-propylamine, 10,11-DIHYDRO-N-METHYL-5H-DIBENZO(A,D)CYCLOHEPTENE-D(SUP5,.GAMMA.)-PROPYLAMINE, 10,11-dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-Delta5,gamma-propylamine, 3-(10,11-Dihydro-5H-dibenzo[a,d] cyclohepten-5-ylidene)-N-methyl-1-propanamine, 3-(5,6-dihydrodibenzo[[?],[?]][7]annulen-11-ylidene)-N-methyl-propan-1-amine, 5H-Dibenzo[a,d]cycloheptene-.DELTA.5,.gamma.-propylamine, 10,11-dihydro-N-methyl-, 21B, methyl(3-{tricyclo[9.4.0.0,3,8]pentadeca-1(15),3,5,7,11,13-hexaen-2-ylidene}propyl)amine
Theoretical properties:
molecular_formula: C19H21N
molecular_weight: 263.4 g/mol
exact_mass: 263.167399674 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 1
rotatable_bond_count: 3
heavy_atom_count: 20
topological_polar_surface_area: 12 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
{"pubchem": "Nortriptyline is an organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline. It has a role as an antidepressant, an analgesic, an antineoplastic agent, an adrenergic uptake inhibitor, a drug metabolite and an apoptosis inducer. It is a secondary amine and an organic tricyclic compound. It is functionally related to an amitriptyline. It derives from a hydride of a dibenzo[a,d][7]annulene.", "chebi": "An organic tricyclic compound that is 10,11-dihydro-5<em>H</em>-dibenzo[<em>a,d</em>][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of  amitriptyline.", "chembl": "NORTRIPTYLINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.", "wikipedia": "Nortriptyline, sold under the brand name Aventyl, among others, is a tricyclic antidepressant. This medicine is also sometimes used for neuropathic pain, attention deficit hyperactivity disorder (ADHD), smoking cessation and anxiety. Its use for young people with depression and other psychiatric disorders may be limited due to increased suicidality in the 18\u201324 population initiating treatment. Nortriptyline is not a preferred treatment for attention deficit hyperactivity disorder or smoking cessation. It is taken by mouth.\nCommon side effects include dry mouth, constipation, blurry vision, sleepiness, low blood pressure with standing, and weakness. Serious side effects may include seizures, an increased risk of suicide in those less than 25 years of age, urinary retention, glaucoma, mania, and a number of heart issues. Nortriptyline may cause problems if taken during pregnancy. Use during breastfeeding appears to be relatively safe. It is a tricyclic antidepressant (TCA) and is believed to work by altering levels of serotonin and norepinephrine.\nNortriptyline was approved for medical use in the United States in 1964. It is available as a generic medication. In 2023, it was the 204th most commonly prescribed medication in the United States, with more than 2 million prescriptions."}