Compound: practolol
SMILES: O=C(Nc1ccc(OCC(O)CNC(C)C)cc1)C
InChIKey: DURULFYMVIFBIR-UHFFFAOYSA-N
Synonyms: practolol, 6673-35-4, Dalzic, Eraldin, Practololum, ICI 50172, ICI-50172, N-[4-[2-HYDROXY-3-[(1-METHYLETHYL)AMINO]PROPOXY]PHENYL]ACETAMIDE, 1-(4-Acetamidophenoxy)-3-isopropylamino-2-propanol, (+-)-Practolol, 4'-(2-Hydroxy-3-(isopropylamino)propoxy)acetanilide, N-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide, N-(4-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}phenyl)acetamide, DTXSID0021179, AY-21011, N-(4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)acetamide, SUG9176GRW, N-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}acetamide, AY-21,011, I.C.I. 50,172, Acetamide, N-(4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)-, Acetamide, N-[4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-, I.C.I.-50,172, DTXCID001179, CHEBI:258351, 4'-[2-Hydroxy-3-(Isopropylamino)propoxy]acetanilide, Practolol, Eralzdin, N-(4-(2-hydroxy-3-(propan-2-ylamino)propoxy)phenyl)acetamide, N-(4-(2-hydroxy-3-((propan-2-yl)amino)propoxy)phenyl)acetamide, ICI50172, RefChem:175688, (3-(4-Acetylamino-Phenoxy)-2-Hydroxy-Propyl)-Isopropyl-Ammonium, 229-712-1, Teranol, Praktololu, rac Practolol, AY 21011, (+/-)-Practolol, CHEMBL6995, N-(4-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)acetamide, N-{4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl}acetamide, Practolol (USAN), MFCD00864573, NCGC00024810-02, Practololo [DCIT], Praktololu [Polish], Practololo, dl-Practolol, PRACTOLOL [USAN], Practololum [INN-Latin], Acetanilide, 4'-(2-hydroxy-3-(isopropylamino)propoxy)-, Acetanilide, 4'-[2-hydroxy-3-(isopropylamino)propoxy]-, Practalol, Prestwick_742, Spectrum_001454, CCRIS 1089, SR-01000597449, EINECS 229-712-1, UNII-SUG9176GRW, N-[4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]acetamide, Practolol [USAN:INN:BAN], rac-Practolol, Practolol,(+), Practolol,(-), CAS-6673-35-4, Practolol (Standard), PRACTOLOL [INN], PRACTOLOL [MI], Prestwick0_000332, Prestwick1_000332, Prestwick2_000332, Prestwick3_000332, Spectrum2_001572, Spectrum4_000859, Spectrum5_001123, GlyTouCan:G01269QN, N-[4-({2-hydroxy-3-[(1-methylethyl)amino]propyl}oxy)phenyl]acetamide, PRACTOLOL [MART.], PRACTOLOL [WHO-DD], Oprea1_095524, SCHEMBL39925, BSPBio_000363, GTPL555, KBioGR_001497, KBioSS_001934, MLS002153779, DivK1c_000901, SPBio_001504, SPBio_002284, BPBio1_000401, Practolol, >=95% (HPLC), BDBM25749, HMS502N03, KBio1_000901, KBio2_001934, KBio2_004502, KBio2_007070, NINDS_000901, HMS1569C05, HMS2089I09, HMS2096C05, HMS2233K23, HMS3374G04, HMS3713C05, ALBB-033372, G01269QN, Tox21_110928, Acetamide,N-[4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-, CCG-39350, EBC-06844, STL489279, AKOS002685374, AKOS016054902, Tox21_110928_1, DB01297, HY-119802R, IDI1_000901, NCGC00024810-03, NCGC00024810-04, NCGC00024810-07, AC-37857, LS-12647, SMR001233163, SBI-0051937.P002, DB-231424, HY-119802, AB00052459, CS-0078043, EN300-72170, D05587, G12676, L000491, Q7237376, SR-01000597449-1, SR-01000597449-2, SR-01000597449-4, 4-[2-Hydroxy-3-(isopropylamino)propoxy]-acetanilide, BRD-A41304429-001-04-9, BRD-A41304429-001-12-2, BRD-A41304429-001-14-8, BRD-A41304429-001-17-1, Z274728816, DL-4'-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)ACETANILIDE, N-(4-[2-Hydroxy-3-(isopropylamino)propoxy]phenyl)acetamide #
Theoretical properties:
molecular_formula: C14H22N2O3
molecular_weight: 266.34 g/mol
exact_mass: 266.16304257 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 3
hydrogen_bond_acceptor_count: 4
rotatable_bond_count: 7
heavy_atom_count: 19
topological_polar_surface_area: 70.6 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
melting_point: 134-136 °C
solubility: 4.90e-01 g/L
Descriptions:
pubchem: Practolol is N-(4-Hydroxyphenyl)acetamide in which the hydrogen of the phenolic hydroxy group is substituted by a 3-(isopropylaminoamino)-2-hydroxypropyl group. A selective beta blocker, it has been used in the emergency treatment of cardiac arrhythmias. It has a role as a beta-adrenergic antagonist and an anti-arrhythmia drug. It is a member of acetamides, a member of ethanolamines, a propanolamine, a secondary alcohol and a secondary amino compound.
chebi: <em>N</em>-(4-Hydroxyphenyl)acetamide in which the hydrogen of the phenolic hydroxy group is substituted by a 3-(isopropylaminoamino)-2-hydroxypropyl group. A selective beta blocker, it has been used in the emergency treatment of cardiac arrhythmias.
chembl: PRACTOLOL is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Practolol (Eraldin, Dalzic, Praktol, Cardiol, Pralon, Cordialina, Eraldina, Teranol) is a beta blocker selective for the β1-adrenergic receptor that has been used in the emergency treatment of cardiac arrhythmias. Practolol is no longer used as it is highly toxic despite the similarity of its chemical formula to propranolol.