Compound: aminophenazone
SMILES: O=c1n(n(C)c(c1N(C)C)C)-c2ccccc2
InChIKey: RMMXTBMQSGEXHJ-UHFFFAOYSA-N
Synonyms: aminophenazone, AMINOPYRINE, Amidopyrine, 58-15-1, 4-Dimethylaminoantipyrine, Dipyrine, Amidazophene, Amidopyrazoline, Aminopyrin, Pyramidon, Amidazophen, Amidophen, Brufaneuxol, Itamidone, Dereuma, Febron, Dimethylaminoantipyrine, Dimethylaminoazophene, Amidofebrin, Amidophenazone, Aminofenazone, Anafebrina, Piridol, Aminophenazon, Amidofen, Amidopyrin, Dimapyrin, Febrinina, Netsusarin, Novamidon, Piromidina, Polinalin, Pyradone, Dipirin, Dimethylaminophenazone, Amidazofen, Piramidon, Dipyrin, 4-Dimethylaminophenazone, 4-(Dimethylamino)antipyrine, Mamallet-A, Aminofenazona, Dimethylaminophenyldimethylpyrazolone, Dimethylamino-analgesine, (Dimethylamino)phenazone, Amidopyrinum, Aminophenazonum, Dimethylaminophenazon, 4-Dimethylamino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, 4-(Dimethylamino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one, Antipyrine, 4-(dimethylamino)-, Mamallet a, 4-Dimethylamino-1-phenyl-2,3-dimethylpyrazolone, 1,5-Dimethyl-4-dimethylamino-2-phenyl-3-pyrazolone, 1-Phenyl-2,3-dimethyl-4-dimethylaminopyrazol-5-one, 2,3-Dimethyl-4-dimethylamino-1-phenyl-5-pyrazolone, 4-Dimethylamino-2,3-dimethyl-1-phenyl-5-pyrazolone, Dimethylaminophenyldimethylpyrazolin, 3H-Pyrazol-3-one, 4-(dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-, 3-Keto-1,5-dimethyl-4-dimethylamino-2-phenyl-2,3-dihydropyrazole, DTXSID7020504, 4-(Dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one, NSC-4993, 1-Phenyl-2,3-dimethyl-4-(dimethylamino)-5-pyrazolone, 01704YP3MO, 3-Pyrazolin-5-one, 4-(dimethylamino)-2,3-dimethyl-1-phenyl-, DTXCID70504, CHEBI:160246, 4-(dimethylamino)-1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one, 1-Phenyl-2,3-dimethyl-4-dimethylaminopyrazolone-5, Amidophenazon, Dimethyl-N-aminoantipyrine, Dimethyl N aminoantipyrine, RefChem:112075, N02BB03, 200-365-8, Pyramidone, Eufibron, Hyparon, Pirazon, Aminopyrine [JAN], Aminophenazone [INN], MFCD00003142, 4-Dimethylamino Antipyrine, 3H-Pyrazol-3-one,4-(dimethylamino)-1,2-dihydro-1,5-dimethyl-2-phenyl-, 4-(dimethylamino)-1,5-dimethyl-2-phenylpyrazol-3-one, MLS002154195, 4-(dimethylamino)-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one, NSC4993, Aminopyrine (JAN), 4-(dimethylamino)-1,5-dimethyl-2-phenyl-pyrazol-3-one, Aminophenazone (INN), CAS-58-15-1, NCGC00016257-04, Amidazophenum, Aminopyrinum, SMR001216566, Aminophenazon [German], Aminofenazone [Italian], Aminofenazona [INN-Spanish], Aminophenazonum [INN-Latin], Dimethylaminophenazon [German], CCRIS 2907, HSDB 2135, Aminopyrine [JAN:NF], SR-05000001741, NSC 4993, EINECS 200-365-8, Piramidone, UNII-01704YP3MO, Amino  pyrine, Dimethylaminophenyldimethylpyrazone, Prestwick_14, AMINOPYRINE [MI], Prestwick0_000088, Prestwick1_000088, Prestwick2_000088, Prestwick3_000088, AMINOPYRINE [HSDB], 4-(Dimethylamino)phenazone, cid_6009, TimTec1_000737, 3-keto-1,3-dihydropyrazole, Oprea1_080671, SCHEMBL26293, BSPBio_000016, 4-N,N-Dimethylaminoantipyrine, 4-Dimethylamino-2,3-dimethyl-1-phenylpyrazol-5-one, SPBio_001955, AMINOPHENAZONE [MART.], BPBio1_000018, CHEMBL288470, AMINOPHENAZONE [WHO-DD], BDBM74258, HMS1536B11, HMS1568A18, HMS2092E10, HMS2095A18, HMS3039C06, HMS3652G13, HMS3712A18, Pharmakon1600-01500621, HY-B0533, Tox21_110333, Tox21_201544, Tox21_302830, EBC-26258, NSC757388, s3209, STL356033, AKOS001590378, Tox21_110333_1, CCG-103785, DB01424, FD22312, NSC-757388, NCGC00016257-01, NCGC00016257-02, NCGC00016257-03, NCGC00016257-05, NCGC00016257-06, NCGC00016257-07, NCGC00016257-10, NCGC00090878-01, NCGC00090878-02, NCGC00090878-03, NCGC00175173-01, NCGC00175173-02, NCGC00256436-01, NCGC00259094-01, 3-Pyrazolin-5-one,3-dimethyl-1-phenyl-, AC-12025, ST011911, SBI-0207073.P001, WLN: T5NNVJ A1 BR& DN1&1 E1, DB-053161, NS00000319, SW196332-3, C07539, D00556, EN300-18532179, Q416503, 1,5-Dimethyl-2-phenyl-4-dimethylamino-3-pyrazolone, SR-05000001741-1, SR-05000001741-3, SR-05000001741-4, 4-(dimethylamino)-1,5-dimethyl-2-phenyl-3-pyrazolone, BRD-K12568846-001-04-7, BRD-K12568846-001-14-6, BRD-K12568846-001-15-3, BRD-K12568846-001-16-1, ,3-Dimethyl-4-dimethylamino-1-phenyl-3-pyrazolin-5-one, 4-(dimethylamino)-1,5-dimethyl-2-phenyl-3-pyrazolin-3-one, 4-Dimethylaminoantipyrine, reactive nitrogen species scavenger, METAMIZOLE SODIUM MONOHYDRATE IMPURITY D [EP IMPURITY], 4-(Dimethylamino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one #, pyrazole, 2,3-dihydro-4-dimethylamino-1,5-dimethyl-3-oxo-2-phenyl-, pyrazole, 4-dimethylamino-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-, 4-DIMETHYLAMINO-1,5-DIMETHYL-2-PHENYL-1,2-DIHYDRO-3H-PYRAZOL-3-ONE, Aminophenazone (4-Dimethylamino-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one), 4-Dimethylamino-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one (4,4-Dimethylaminophenazone)
Theoretical properties:
molecular_formula: C13H17N3O
molecular_weight: 231.29 g/mol
exact_mass: 231.137162174 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 3
rotatable_bond_count: 2
heavy_atom_count: 17
topological_polar_surface_area: 26.8 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
physical_state: LEAFLETS FROM LIGROIN
color: LEAFLETS FROM LIGROIN
odor: ODORLESS
melting_point: 225 to 228 °F (NTP, 1992)
solubility: greater than or equal to 100 mg/mL at 72 °F (NTP, 1992)
Descriptions:
pubchem: Aminophenazone is a pyrazolone that is 1,2-dihydro-3H-pyrazol-3-one substituted by a dimethylamino group at position 4, methyl groups at positions 1 and 5 and a phenyl group at position 2. It exhibits analgesic, anti-inflammatory, and antipyretic properties. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic, a xenobiotic and an environmental contaminant. It is a tertiary amino compound and a pyrazolone.
chebi: A  pyrazolone  that is 1,2-dihydro-3<em>H</em>-pyrazol-3-one substituted by a dimethylamino group at position 4, methyl groups at positions 1 and 5 and a phenyl group at position 2. It exhibits analgesic, anti-inflammatory, and antipyretic properties.
chembl: AMINOPYRINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Aminophenazone (or aminopyrine, amidopyrine, Pyramidon) is a non-narcotic analgesic substance. It is a pyrazolone and a derivative of phenazone, which also has anti-inflammatory and antipyretic properties. While inexpensive and effective, especially in the treatment of rheumatism, the drug carries a serious risk of severe and sometimes fatal side-effects, including agranulocytosis. While its production and use have been banned in many countries, including France, Thailand, India, Japan and USA, it is still sometimes used in the developing world.
A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of cytochrome P-450 metabolic activity in liver-function tests. It is also used in measuring the total body water in the human body system.