Compound: ropinirole
SMILES: O=C1Nc2cccc(c2C1)CCN(CCC)CCC
InChIKey: UHSKFQJFRQCDBE-UHFFFAOYSA-N
Synonyms: ropinirole, 91374-21-9, ropinirol, Ropinirolum, Ropitor, SKF 101468, SK&F 101468, 4-[2-(dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one, Narapin, NSC-758917, DTXSID8045195, 030PYR8953, SK&F-101468, CHEBI:8888, DTXCID6025195, Adartrel, 4-[2-(dipropylamino)ethyl]-2,3-dihydro-1h-indol-2-one, 2H-Indol-2-one, 4-(2-(dipropylamino)ethyl)-1,3-dihydro-, SK&F-101468A, 4-(2-(Dipropylamino)ethyl)-1,3-dihydro-2H-indol-2-one, 4-(2-(dipropylamino)ethyl)-3H-indol-2-ol, 4-[2-(dipropylamino)ethyl]-3H-indol-2-ol, 4-(2-(dipropylamino)ethyl)-2,3-dihydro-1H-indol-2-one, SK&F-101,468, CLEVOR, RefChem:57482, N04BC04, 4-(2-(di-n-propylamino)ethyl)-2(3H)-indolone, Ropinirolum [INN-Latin], Ropinirol [INN-Spanish], 4-(2-(dipropylamino)ethyl)indolin-2-one, 4-[2-(dipropylamino)ethyl]-1,3-dihydroindol-2-one, CHEMBL589, NCGC00015893-02, 4-[2-(dipropylamino)ethyl]indolin-2-one, Ropitor (TN), CAS-91374-21-9, Ropinirole [USAN:INN:BAN], UNII-030PYR8953, SKF-101468, ROPINIROLE [MI], ROPINIROLE [INN], Ropinirole (USAN/INN), Lopac-R-4152, ROPINIROLE [USAN], ROPINIROLE [VANDF], ROPINIROLE [WHO-DD], Lopac0_001101, SCHEMBL35212, BIDD:GT0826, SPECTRUM1505178, GTPL7295, orb1689604, SCHEMBL27885263, SCHEMBL29374522, HSDB 8252, HMS2093K04, Pharmakon1600-01505178, HY-B0623, Tox21_110256, BDBM50020680, EBC-26355, MFCD00864147, NSC758917, STL454344, AKOS015843123, Tox21_110256_1, CCG-205177, DB00268, FR32034, NSC 758917, SB65618, SDCCGSBI-0051070.P002, 4-[2-(Dipropylamino)ethyl]2-indolinone, NCGC00015893-01, NCGC00015893-03, NCGC00015893-04, NCGC00015893-06, NCGC00094373-12, NCGC00096064-01, NCGC00096064-02, CS-0009561, NS00008049, C07564, D08489, EN300-708794, G78293, AB01563044_01, AB01563044_02, 4-(2-dipropylaminoethyl)-1,3-dihydroindol-2-one, L000520, Q420590, SR-01000076215-3, BRD-K15933101-003-01-2, BRD-K15933101-003-06-1, BRD-K15933101-003-07-9, 4-[2-(dipropylamino)ethyl]-1.3-dihydro-2H-indol-2-one
Theoretical properties:
molecular_formula: C16H24N2O
molecular_weight: 260.37 g/mol
exact_mass: 260.188863393 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 7
heavy_atom_count: 19
topological_polar_surface_area: 32.3 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
boiling_point: 410.5±45.0 °C at 760 mmHg
melting_point: 243-250 °C
Descriptions:
pubchem: Ropinirole is a member of indolones and a tertiary amine. It has a role as a central nervous system drug, an antiparkinson drug, a dopamine agonist and an antidyskinesia agent.
chembl: ROPINIROLE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Ropinirole, sold under the brand name Requip among others, is a medication used to treat Parkinson's disease (PD) and restless legs syndrome (RLS). It is taken by mouth.
Common side effects include sleepiness, vomiting, and dizziness. Serious side effects may include pathological gambling, hypersexuality, low blood pressure with standing and hallucinations. Use in pregnancy and breastfeeding is of unclear safety. It is a dopamine agonist and works by triggering dopamine D2 receptors.
It was approved for medical use in the United States in 1997. It is available as a generic medication. In 2023, it was the 212th most commonly prescribed medication in the United States, with more than 2 million prescriptions.