Compound: RefChem:912168
SMILES: O=C(Nc1ccc(Nc2ncnc3c2cc(OC)c(c3)OCCCN4CCOCC4)cc1)c5ccccc5
InChIKey: OGNYUTNQZVRGMN-UHFFFAOYSA-N
Synonyms: RefChem:912168, 4-(4-(n-benzoylamino)anilino)-6-methoxy-7-(3-(1-morpholino)propoxy)quinazoline, 331771-20-1, ZM-447439, ZM447439, ZM 447439, N-[4-[[6-METHOXY-7-[3-(4-MORPHOLINYL)PROPOXY]-4-QUINAZOLINYL]AMINO]PHENYL]BENZAMIDE, N-(4-((6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-yl)amino)phenyl)benzamide, TCMDC-125873, C29H31N5O4, N-[4-({6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinazolin-4-yl}amino)phenyl]benzamide, CHEMBL202721, RSN3P9776R, N-[4-[[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino]phenyl]benzamide, N-[4-[[6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-yl]amino]phenyl]benzamide, Benzamide, N-(4-((6-methoxy-7-(3-(4-morpholinyl)propoxy)-4-quinazolinyl)amino)phenyl)-, ZM447439 (ZM-447439), N-(4-{[6-Methoxy-7-(3-Morpholin-4-Ylpropoxy)quinazolin-4-Yl]amino}phenyl)benzamide, UNII-RSN3P9776R, N-(4-((6-methoxy-7-(3-(4-morpholinyl)propoxy)-4-quinazolinyl)amino)phenyl)benzamide, OGNYUTNQZVRGMN-UHFFFAOYSA-N, MFCD08703125, Kinome_3319, NCGC00159574-01, MLS006010133, SCHEMBL597105, GTPL8353, orb1301094, SCHEMBL29377224, BDBM14210, CHEBI:91376, DTXSID00186833, GLXC-04292, HMS3269E21, HMS3295A17, HMS3413O12, HMS3654I21, HMS3677O12, EX-A2276, HB1444, s1103, ZM 447439 [WHO-DD], AKOS015919490, AC-8444, CCG-269800, CS-0009, SB19303, SDCCGSBI-0654270.P002, NCGC00159574-02, NCGC00159574-09, AS-16711, HY-10128, SMR004701259, SW220282-1, C74700, Q8063129, BRD-K72703948-001-01-0, BRD-K72703948-001-02-8, BRD-K72703948-001-09-3, BRD-K72703948-001-10-1, BRD-K72703948-001-12-7, 4-(4-(N-benzoylamino)anilino)-6-methoxy-7-(3-(1-morpholino)propoxy)-quinazoline, N-(4-(6-Methoxy-7(3-morpholinepropoxy)quinazolin-4-ylamino)phenyl)benzamide, N-{4-[6-Methoxy-7-(3-morpholin-4-yl-propoxy)-quinazolin-4-ylamino]-phenyl}-benzamide, Benzamide, N-?[4-?[[6-?methoxy-?7-?[3-?(4-?morpholinyl)?propoxy]?-?4-?quinazolinyl]?amino]?phenyl]?-
Theoretical properties:
molecular_formula: C29H31N5O4
molecular_weight: 513.6 g/mol
exact_mass: 513.23760449 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 2
hydrogen_bond_acceptor_count: 8
rotatable_bond_count: 10
heavy_atom_count: 38
topological_polar_surface_area: 97.8 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: ZM447439 is a member of the class of quinazolines that is quinazoline which is substituted at positions 4, 6 and 7 by a (4-benzamidophenyl)nitrilo group, methoxy group and a 3-(morpholin-4-yl)propoxy group, respectively. It is an ATP-competitive inhibitor of Aurora A and Aurora B kinases with IC50 of 110 nM and 130 nM, respectively. It has a role as an antineoplastic agent, an apoptosis inducer and an Aurora kinase inhibitor. It is a member of benzamides, an aromatic ether, a member of quinazolines, a member of morpholines, a polyether, a secondary amino compound and a tertiary amino compound.
chebi: A member of the class of quinazolines that is quinazoline which is substituted at positions 4, 6 and 7 by a (4-benzamidophenyl)nitrilo group, methoxy group and a 3-(morpholin-4-yl)propoxy group, respectively. It is an ATP-competitive inhibitor of Aurora A and Aurora B kinases with IC<small><sub>50</sub></small> of 110 nM and 130 nM, respectively.