Compound: carbidopa
SMILES: O=C(O)[C@@](NN)(Cc1cc(O)c(O)cc1)C
InChIKey: TZFNLOMSOLWIDK-JTQLQIEISA-N
Synonyms: carbidopa, 28860-95-9, Lodosyn, Carbidopa anhydrous, (S)-(-)-carbidopa, N-Aminomethyldopa, alpha-Methyldopahydrazine, Carbidopum, L-alpha-Methyldopahydrazine, Carbidopa (anhydrous), (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid, (S)-carbidopa, MK 486, L-3-(3,4-Dihydroxyphenyl)-2-methyl-2-hydrazinopropionic acid, (-)-L-alpha-Hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid, KR87B45RGH, MK-486, (alphaS)-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid, DTXSID4022735, DTXCID502735, CHEBI:39585, (-)-L-alpha-Hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid monohydrate, Benzenepropanoic acid, alpha-hydrazino-3,4-dihydroxy-alpha-methyl-, (S)-, Carbidopum monohydrate, NSC-751137, CHEBI:3395, Methyldopahydrazine, DHIVY COMPONENT CARBIDOPA, DUOPA COMPONENT CARBIDOPA, RYTARY COMPONENT CARBIDOPA, CREXONT COMPONENT CARBIDOPA, STALEVO COMPONENT CARBIDOPA, CORBILTA COMPONENT CARBIDOPA, NSC-758190, MK485, Carbidopa Tablets, LEVODOPA/CARBIDOPA/ENTACAPONE ORION COMPONENT CARBIDOPA, L-Carbidopa Anhydrous, RefChem:918027, Carbidopa Tablets, 25 mg, MK486, (2S)-2-(azaniumylamino)-3-(3,4-dihydroxyphenyl)-2-methylpropanoate, Benzenepropanoic Acid, alpha-hydrazino-3,4-dihydroxy-alpha-methyl-,(S)-, 249-271-9, 657-445-4, (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrate, Benzenepropanoic acid, alpha-hydrazino-3,4-dihydroxy-alpha-methyl-, monohydrate, (S)-, MNX7R8C5VO, S-(-)-Carbidopa, Carbidopum [INN-Latin], S(-)-CARBIDOPA, Carbidopa [INN], (S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid, MFCD00069231, (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid, CARBIDOPA, L- ANHYDROUS, NCGC00024596-05, (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazino-2-methyl-propanoic acid, Hadrazino-alpha-methyldopa, alpha-Hydrazino-alpha-methyl-beta-(3,4-dihydroxyphenyl)propionic acid, C-DOPA, S-(-)-Carbidopa monohydrate, 3,3,3-trideuterio-2-[dideuterio-(3,4-dihydroxyphenyl)methyl]-2-hydrazinylpropanoic acid, SMR000058235, CCRIS 5093, SR-01000597655, EINECS 249-271-9, UNII-KR87B45RGH, Neo-Dopaston, Lodosyn;, Lodysin;, Menesit;, Benzenepropanoic acid, .alpha.-hydrazino-3,4-dihydroxy-.alpha.-methyl-, (S)-, 28860-95-9 (anhydrous), L-alpha-Methyl-alpha-hydrazino-beta-(3,4-dihydroxyphenylpropionic acid, L-alpha-Methyl-beta-(3,4-dihydroxyphenyl)-alpha-hydrazinopropionic acid, ND0611, Tocris-0455, C-126, CARBIDOPA [WHO-DD], Lopac0_000382, SCHEMBL35084, MLS000069628, MLS002207014, GTPL5159, orb1300458, CARBIDOPA ANHYDROUS [MI], CHEMBL1201236, SCHEMBL29392554, GLXC-06131, HMS2089B12, HMS3266A20, HMS3411M13, HMS3655G20, HMS3675M13, HMS3713L10, HMS3884M14, HY-B0311, Tox21_110910, BDBM50418773, EBC-01053, NSC751137, s1891, SBB000659, AKOS015969657, HYDROCINNAMIC ACID, alpha-HYDRAZINO-3,4-DIHYDROXY-alpha-METHYL-, L-, AC-1676, CCG-204476, DB00190, SDCCGMLS-0072919.P025, MLS-0072919, SMP1_000057, NCGC00024596-01, NCGC00024596-03, NCGC00024596-06, NCGC00024596-07, NCGC00024596-08, AS-16862, BC164279, ST055523, MLS-0072919.P013, CAS-28860-95-9, C2450, EU-0100382, NS00005042, SW199080-2, AB00441332-05, AB00441332-06, AB00441332_07, AB00441332_08, EN300-6733817, SR-01000597655-1, SR-01000597655-3, SR-01000597655-5, SR-01000597655-9, BRD-K78712176-001-07-5, BRD-K78712176-001-11-7, BRD-K78712176-001-12-5, BRD-K78712176-001-13-3, BRD-K78712176-001-14-1, Z2301684895, (-)-L-alpha-Hydrazino-3,4-dihydroxy-alpha-methylhydrocinamic Acid, (S)-3-(3,4-dihydroxyphenyl)-2-hydrazineyl-2-methylpropanoic acid, (S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropionic Acid, (S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoicacid, (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazino-2-methylpropionic acid monohydrate, Benzenepropanoic acid, .alpha.-hydrazinyl-3,4-dihydroxy-.alpha.-methyl-, (.alpha.S)-, KINSON; 3-(3,4-DIHYDROXY-PHENYL)-2-HYDRAZINO-2-METHYL-PROPIONIC ACID, 1426847-87-1
Theoretical properties:
molecular_formula: C10H14N2O4
molecular_weight: 226.23 g/mol
exact_mass: 226.09535693 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 5
hydrogen_bond_acceptor_count: 6
rotatable_bond_count: 4
heavy_atom_count: 16
topological_polar_surface_area: 116 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
boiling_point: Decomposes
melting_point: 203-208 °C
Descriptions:
pubchem: Carbidopa (anhydrous) is 3-(3,4-Dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used (commonly as its hydrate) in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa. It has a role as an antiparkinson drug, a dopaminergic agent and an EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor. It is a member of hydrazines, a monocarboxylic acid and a member of catechols.
chebi: 3-(3,4-Dihydroxyphenyl)propanoic acid in which the hydrogens α- to the carboxyl group are substituted by hydrazinyl and methyl groups (<i>S</i>-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used (commonly as its hydrate) in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa.
chembl: CARBIDOPA ANHYDROUS is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Carbidopa, sold under the brand name Lodosyn, is a medication used primarily in the treatment of Parkinson's disease. It is a DOPA decarboxylase inhibitor — that is, it blocks the enzyme aromatic L-amino acid decarboxylase (DDC) in the peripheral nervous system, preventing the premature conversion of levodopa to dopamine outside the brain. Because carbidopa cannot cross the blood-brain barrier, it has no effect on DDC activity within the central nervous system, allowing a greater proportion of co-administered levodopa to reach the brain intact.