Compound: trimethadione
SMILES: O=C1OC(C)(C)C(N1C)=O
InChIKey: IRYJRGCIQBGHIV-UHFFFAOYSA-N
Synonyms: trimethadione, 127-48-0, Tridione, Troxidone, Trimethadion, Absentol, Epidione, Trimetadione, Minoaleviatin, Ptimal, Convenixa, Petimalin, Absetil, Petilep, Edion, Epixal, Tridone, Trimetadiona, Trimethadionum, Trimethinum, 2,4-OXAZOLIDINEDIONE, 3,5,5-TRIMETHYL-, 3,5,5-Trimethyl-1,3-oxazolidine-2,4-dione, 3,5,5-Trimethyl-2,4-oxazolidinedione, A 2297, trimethyl-1,3-oxazolidine-2,4-dione, DTXSID9021396, Tridione Dulcet, R7GV3H6FQ4, NSC-15799, NSC-169503, J2.519D, CHEBI:9727, DTXCID801396, NSC15799, RefChem:56172, N03AC02, 204-845-8, Trimetin, Petidon, Trimedal, Convexina, Tioxanona, Tridilona, Trimethin, Tridion, 3,5,5-Trimethyloxazolidine-2,4-dione, Trimethdione, Trimedone, Minoaleuiatin, Tredione, Tricione, Trilidona, Triozanona, Tromedone, Epidone, Etydion, Pitmal, Mino-Aleviatin, 3,3,5-Trimethyl-2,4-diketooxazolidine, 3,5,5,-Trimethyloxazolidine-2,4-dione, MFCD00047084, NSC 15799, 3,5,5-Trojmetylooksazolidyno-2,4-dion, Trioksal, 3,5,5-TRIMETHYL-OXAZOLIDINE-2,4-DIONE, s5567, NCGC00016383-01, CAS-127-48-0, Trimetadione [DCIT], 2, 3,5,5-trimethyl-, Trimetadiona [INN-Spanish], Trimethadionum [INN-Latin], 3,5-Trimethyl-2,4-oxazolidinedione, 3,5-Trimethyl-2,4-diketooxazolidine, WLN: T5OVNV EHJ C1 E1 E1, Tridione (TN), EINECS 204-845-8, 3,5,5-Trojmetylooksazolidyno-2,4-dion [Polish], UNII-R7GV3H6FQ4, BRN 0121627, Mino aleviatin, Trimethadione CRS, Trimethadione [USP:INN:BAN:JAN], Prestwick_815, Trimethadione (Standard), Prestwick0_000515, Prestwick1_000515, Prestwick2_000515, Prestwick3_000515, TRIMETHADIONE [MI], CHEMBL695, TRIMETHADIONE [INN], TRIMETHADIONE [JAN], Trimethadione (JP18/INN), SCHEMBL28882, BSPBio_000469, TRIMETHADIONE [VANDF], MLS001076685, TRIMETHADIONE [MART.], SPBio_002390, TRIMETHADIONE [USP-RS], TRIMETHADIONE [WHO-DD], TRIMETHADIONE [WHO-IP], BPBio1_000517, GTPL7316, orb1310760, HY-A0092R, IRYJRGCIQBGHIV-UHFFFAOYSA-, HMS1569H11, HMS2093D10, HMS2096H11, HMS2235E12, HMS3713H11, HMS3886I12, HMS5084N20, Pharmakon1600-01505466, TRIMETHADIONE [ORANGE BOOK], AAA12748, HY-A0092, Tox21_110408, Tox21_200231, TRIMETHADIONE [EP MONOGRAPH], BDBM50227239, EBC-12262, NSC169503, NSC759152, Trimethadione 1.0 mg/ml in Methanol, TRIMETHADIONUM [WHO-IP LATIN], AKOS006229172, CCG-213460, DB00347, NSC-759152, NCGC00016383-02, NCGC00016383-03, NCGC00016383-05, NCGC00257785-01, BS-15128, DA-78621, SMR000499583, SBI-0206923.P001, NS00024046, ST50411784, D00392, D84162, EN300-123536, 3,5,5-Trimethyl-1,3-oxazolidine-2,4-dione #, Q827916, SR-01000763540, SR-01000763540-2, BRD-K16606819-001-07-7, BRD-K16606819-001-10-1, BRD-K16606819-001-11-9, BRD-K16606819-001-12-7, Z1201618106, 3,5,5,-Trimethyloxazolidine-2,4-dione, analytical standard, Trimethadione, European Pharmacopoeia (EP) Reference Standard, InChI=1/C6H9NO3/c1-6(2)4(8)7(3)5(9)10-6/h1-3H3
Theoretical properties:
molecular_formula: C6H9NO3
molecular_weight: 143.14 g/mol
exact_mass: 143.058243149 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 3
rotatable_bond_count: 0
heavy_atom_count: 10
topological_polar_surface_area: 46.6 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Trimethadione can cause developmental toxicity according to state or federal government labeling requirements.
chebi: An oxazolidinone that is 1,3-oxazolidine-2,4-dione substituted by methyl groups at positions 3, 5 and 5. It is an antiepileptic agent.
chembl: TRIMETHADIONE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Trimethadione (Tridione) is an oxazolidinedione anticonvulsant. It is most commonly used to treat epileptic conditions that are resistant to other treatments.
It is primarily effective in treating absence seizures, but can also be used in refractory temporal lobe epilepsy. It is usually administered 3 or 4 times daily, with the total daily dose ranging from 900 mg to 2.4 g. Treatment is most effective when the concentration of its active metabolite, dimethadione, is above 700 μg/mL. Severe adverse reactions are possible, including Steven Johnson syndrome, nephrotoxicity, hepatitis, aplastic anemia, neutropenia, or agranulocytosis. More common adverse effects include drowsiness, hemeralopia, and hiccups.