Compound: tolterodine
SMILES: Oc1c(cc(C)cc1)[C@@H](c2ccccc2)CCN(C(C)C)C(C)C
InChIKey: OOGJQPCLVADCPB-HXUWFJFHSA-N
Synonyms: tolterodine, 124937-51-5, (+)-Tolterodine, Tolterodinum, Kabi 2234, Tolterodina, Kabi-2234, WHE7A56U7K, 2-[(1R)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-methylphenol, (+)-(R)-2-(alpha-(2-(Diisopropylamino)ethyl)benzyl)-p-cresol, CHEBI:9622, 2-[(1R)-3-[bis(propan-2-yl)amino]-1-phenylpropyl]-4-methylphenol, Detrusitol xl, Efflosomyl xl, Mariosea xl, Preblacon xl, Santizor xl, 2-((1R)-3-(bis(propan-2-yl)amino)-1-phenylpropyl)-4-methylphenol, 2-((1R)-3-(di(propan-2-yl)amino)-1-phenylpropyl)-4-methylphenol, 2-[(1R)-3-(di(propan-2-yl)amino)-1-phenylpropyl]-4-methylphenol, 2-{(1R)-3-[Di(propan-2-yl)amino]-1-phenylpropyl}-4-methylphenol, Blerone xl, Inconex xl, Neditol xl, RefChem:56377, G04BD07, R-(+)-Tolterodine, Tolterodine [INN], Tolterodinum [INN-Latin], Tolterodina [INN-Spanish], Urotrol, Phenol, 2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-methyl-, 2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-methylphenol, S-(-)-Tolterodine, CHEMBL1382, (r)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-methylphenol, DTXSID3023687, (R)-(+)-Tolterodine, NCGC00159519-02, tolterodin, DTXCID703687, Unidet, Tolterodine (racemate), SMR000596518, CAS-124937-51-5, C22H31NO, UNII-WHE7A56U7K, PNU 200583, Tolterodine [USAN:INN:BAN], Phenol, 2-((1R)-3-(bis(1-methylethyl)amino)-1-phenylpropyl)-4-methyl-, 2-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol; (R)-(+)-N,N-Diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropylamine;, PHA-686464B, Tolterondine Tartrate, TOLTERODINE [MI], Tolterodine (USAN/INN), TOLTERODINE [USAN], TOLTERODINE [VANDF], SCHEMBL3064, GTPL360, TOLTERODINE [WHO-DD], MLS001195620, MLS001304745, BIDD:GT0318, orb1704166, SCHEMBL29379290, HMS2230E24, HY-A0024, tolterodine extended release capsules, Tox21_111737, 2-{(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl}-4-methylphenol, BDBM50165008, EBC-04424, AKOS015841711, AKOS015895578, Tox21_111737_1, AC-3472, CS-1799, DB01036, KS-5165, NCGC00159519-01, NCGC00159519-04, NCGC00159519-14, NCGC00263557-01, 2-[3-[Bis(1-Methylethyl)Amino]-1-Phenylpropyl]-4-Methyl Phenol Monohydrobromide, DB-260460, C07750, D00646, H10328, AB00698547-12, AB00698547_13, EN300-1709733, Q424312, BRD-K54316499-046-04-5, BRD-K54316499-046-05-2, 2-[(1R)-3-(diisopropylamino)-1-phenyl-propyl]-4-methyl-phenol, 2-[(1r)3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol, (+)-(R)-3-(2-hydroxy-5-methylphenyl)-N,N-diisopropyl-3-phenylpropylamine, PNU-200583 racemate; PNU 200583 racemate; PNU200583 racemate; ()-Tolterodine; Racemic tolterodine
Theoretical properties:
molecular_formula: C22H31NO
molecular_weight: 325.5 g/mol
exact_mass: 325.240564612 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 7
heavy_atom_count: 24
topological_polar_surface_area: 23.5 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
solubility: 5.34e-03 g/L
Descriptions:
pubchem: Tolterodine is a tertiary amine. It has a role as a muscarinic antagonist, a muscle relaxant and an antispasmodic drug. It is functionally related to a p-cresol.
chembl: TOLTERODINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Tolterodine, sold under the brand name Detrol among others, is a medication used to treat frequent urination, urinary incontinence, or urinary urgency. Effects are seen within an hour. It is taken by mouth.
Common side effects include headache, dry mouth, constipation, and dizziness. Serious side effects may include angioedema, urinary retention, and QT prolongation. Use in pregnancy and breastfeeding are of unclear safety. It works by blocking muscarinic receptors in the bladder thus decreasing bladder contractions.
Tolterodine was approved for medical use in 1998. It is available as a generic medication. In 2020, it was the 271st most commonly prescribed medication in the United States, with more than 1 million prescriptions.