Compound: vesnarinone
SMILES: O=C1Nc2c(cc(N3CCN(C(=O)c4cc(OC)c(OC)cc4)CC3)cc2)CC1
InChIKey: ZVNYJIZDIRKMBF-UHFFFAOYSA-N
Synonyms: vesnarinone, 81840-15-5, OPC-8212, Arkin-Z, Vesnarinona, Arkin, Arkin Z, Vesnarinonum, DRG-0210, 5COW40EV8M, DTXSID80231411, 1-(3,4-Dimethoxybenzoyl)-4-(1,2,3,4-tetrahydro-2-oxo-6-quinolinyl)piperazine, pieranometazine, 6-(4-((3,4-dimethoxyphenyl)carbonyl)piperazin-1-yl)-1,2,3,4-tetrahydroquinolin-2-one, 6-{4-[(3,4-dimethoxyphenyl)carbonyl]piperazin-1-yl}-1,2,3,4-tetrahydroquinolin-2-one, RefChem:901829, 3,4-dihydro-6-(4-(3,4-dimethoxybenzoyl)-1-piperazinyl)-2-1H-quinolinone, DTXCID80153902, 3,4-Dihydro-6-(4-(3,4-dimethoxybenzoyl)-1-pip-erazinyl)-2(1H)-quinolinone, Piperazine, 1-(3,4-dimethoxybenzoyl)-4-(1,2,3,4-tetrahydr-o-2-oxo-6-quinolinyl), 6-[4-(3,4-dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one, 6-(4-(3,4-dimethoxybenzoyl)piperazin-1-yl)-3,4-dihydroquinolin-2(1H)-one, 6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro-2(1h)-quinolinone, MFCD00867124, CHEMBL17423, Piteranometozine, Piperazine, 1-(3,4-dimethoxybenzoyl)-4-(1,2,3,4-tetrahydro-2-oxo-6-quinolinyl)-, Vesnarinonum [Latin], Vesnarinona [Spanish], Vesnarinone [USAN:INN:JAN], CCRIS 1451, UNII-5COW40EV8M, BRN 5644229, 6-[4-(3,4-Dimethoxybenzoyl)piperazin-1-yl]-3,4-dihydroquinolin-2(1H)-one, Arkin (TN), Arkin Z (TN), VESNARINONE [MI], 1-(1,2,3,4-Tetrahydro-2-oxo-6-quinolyl)-4-veratroylpiperazine, 6-(4-(3,4-Dimethoxybenzoyl)-1-piperazinyl)-3,4-dihydro-2(1H)-, VESNARINONE [INN], VESNARINONE [JAN], VESNARINONE [USAN], Vesnarinone(OPC8212)?, 3,4-Dihydro-6-(4-(3,4-dimethoxybenzoyl)-1-piperazinyl)-2(1H)-quinolinone, VESNARINONE [VANDF], VESNARINONE [MART.], SCHEMBL50993, VESNARINONE [WHO-DD], Vesnarinone (JAN/USAN/INN), orb1304177, SCHEMBL29402965, CHEBI:31237, EX-A718, OPC8212, GLXC-03078, BDBM50016980, OPC-8212; Piteranometozine; Arkin, 6-(4-(3,4-Dimethoxybenzoyl)-1-piperazinyl)-3,4-dihydro-2(1H)-quinolone, AKOS027475338, CS-5387, DB12082, NCGC00510509-02, HY-15297, MS-26657, DB-056556, NS00069189, D01690, Q7923264, BRD-K13414800-001-01-3, 6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydrocarbostyril, [4-(3,4-Dihydro-quinolin-6-yl)-piperazin-1-yl]-(3,4-dimethoxy-phenyl)-methanone, 3,4-Dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2-(1H)-quinolinone, 6-[4-(3,4-Dimethoxy-benzoyl)-piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one, 6-[4-(3,4-Dimethoxy-benzoyl)-piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one(OPC-8212)
Theoretical properties:
molecular_formula: C22H25N3O4
molecular_weight: 395.5 g/mol
exact_mass: 395.18450629 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 5
rotatable_bond_count: 4
heavy_atom_count: 29
topological_polar_surface_area: 71.1 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Arkin (TN) is an organic molecular entity.
chembl: VESNARINONE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 2.0.
wikipedia: Vesnarinone (INN) is a cardiotonic agent.
A mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. Vesnarinone improves ventricular performance most in patients with the worst degree of heart failure.