Compound: Nepafenac
SMILES: O=C(c1c(N)c(ccc1)CC(=O)N)c2ccccc2
InChIKey: QEFAQIPZVLVERP-UHFFFAOYSA-N
Synonyms: Nepafenac, 78281-72-8, 2-(2-Amino-3-benzoylphenyl)acetamide, Nevanac, 2-Amino-3-benzoylbenzeneacetamide, AHR-9434, Ilevro, AL-6515, nepafenaco, AL 6515, nepafenacum, 0J9L7J6V8C, DTXSID0048638, CHEBI:75922, DTXCID7028564, Nepafenac [USAN:INN:BAN:JAN], 2-[2-amino-3-(benzoyl)phenyl]acetamide, Nepafenac (USAN:INN:BAN:JAN), 2-(2-amino-3-(benzoyl)phenyl)acetamide, RefChem:55703, S01BC10, 682-241-7, AHR 9434, Benzeneacetamide, 2-amino-3-benzoyl-, MFCD08067732, AHR 9434;AL 6515, NCGC00185741-01, Nepafenac [USAN], Amfenac amide, SMR002529588, CAS-78281-72-8, UNII-0J9L7J6V8C, 2-amino-3-benzoyl-benzeneacetamide, Benzeneacetamide, 2-amino-3-benzoyl-; 2-Amino-3-benzoylbenzeneacetamide; AHR 9434; AL 6515; Nepafenac; Nevanac, Nevanac (TN), Nepafenac (Standard), 2-(2-amino-3-benzoyl-phenyl)acetamide, NEPAFENAC [INN], NEPAFENAC [JAN], NEPAFENAC [MI], NEPAFENAC [VANDF], NEPAFENAC [MART.], NEPAFENAC [USP-RS], NEPAFENAC [WHO-DD], CHEMBL1021, SCHEMBL93835, NEPAFENAC [EMA EPAR], MLS003915618, MLS004774140, MLS006010644, Nepafenac (JAN/USAN/INN), GTPL7564, orb1309140, NEPAFENAC [ORANGE BOOK], Nepafenac, >=98% (HPLC), SCHEMBL29377340, QEFAQIPZVLVERP-UHFFFAOYSA-N, 2-Amino-3-benzoyl-phenylacetamide, GLXC-07010, HMS3654P07, HMS3884E07, HMS5079D03, EX-A1350, Tox21_112985, BDBM50228731, EBC-11199, HY-17357R, s1255, STL451069, AKOS005146108, Tox21_112985_1, AC-6949, CCG-267004, CS-0899, DB06802, FN59490, NCGC00185741-02, AS-19176, HY-17357, N0932, NS00006647, SW219197-1, 2-[2-amino-3-(phenylcarbonyl)phenyl]acetamide, A12846, D05143, SBI-0654191.0001, AB01274763-01, AB01274763_02, EN300-7418512, Q684379, SR-01000931908, SR-01000931908-2, BRD-K04112579-001-02-1, BRD-K04112579-001-07-0
Theoretical properties:
molecular_formula: C15H14N2O2
molecular_weight: 254.28 g/mol
exact_mass: 254.105527694 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 2
hydrogen_bond_acceptor_count: 3
rotatable_bond_count: 4
heavy_atom_count: 19
topological_polar_surface_area: 86.2 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Nepafenac is a monocarboxylic acid amide that is amfenac in which the carboxylic acid group has been converted into the corresponding carboxamide. It is a prodrug for amfenac, used in eye drops to treat pain and inflammation following cataract surgery. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, a prodrug, a cyclooxygenase 2 inhibitor and a cyclooxygenase 1 inhibitor.
chebi: A monocarboxylic acid amide that is amfenac in which the carboxylic acid group has been converted into the corresponding carboxamide. It is a prodrug for amfenac, used in eye drops to treat pain and inflammation following cataract surgery.
chembl: NEPAFENAC is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Nepafenac, sold under the brand name Nevanac among others, is a nonsteroidal anti-inflammatory drug (NSAID), usually sold as a prescription eye drop 0.1% solution (Nevanac) or 0.3% solution (Ilevro). It is used to treat pain and inflammation associated with cataract surgery. Nepafenac is a prodrug of amfenac, an inhibitor of COX-1 and COX-2 activity.