Compound: mefenamic acid
SMILES: O=C(O)c1c(Nc2c(c(ccc2)C)C)cccc1
InChIKey: HYYBABOKPJLUIN-UHFFFAOYSA-N
Synonyms: mefenamic acid, 61-68-7, Ponstel, 2-[(2,3-dimethylphenyl)amino]benzoic acid, Mephenamic acid, 2-((2,3-Dimethylphenyl)amino)benzoic acid, Mephenaminic acid, Ponstan, Methenamic acid, Vialidon, Lysalgo, Tanston, Acide mefenamique, Mefenaminsaeure, CN-35355, N-2,3-Xylylanthranilic acid, Acido mefenamico, Mefenaminic Acid, INF-3355, CI-473, Acidum mefenamicum, INF 3355, N-(2,3-Xylyl)-2-aminobenzoic acid, N-(2,3-Dimethylphenyl)anthranilic acid, Gardan, Anthranilic acid, N-2,3-xylyl-, 2-(2,3-dimethylphenylamino)benzoic acid, Benzoic acid, 2-[(2,3-dimethylphenyl)amino]-, CN 35355, DTXSID5023243, NSC-94437, Benzoic acid, 2-((2,3-dimethylphenyl)amino)-, J2.344B, 2-Diphenylaminecarboxylic acid, 2',3'-dimethyl-, CHEBI:6717, M01AG01, Benzoic acid, 2-(2,3-dimethylphenyl)amino-, NSC94437, 367589PJ2C, DTXCID103243, Mefenamicacid, Mendys, Ponstan fte, Opustan 250, Opustan 500, Dysman-250, Dysman-500, Meflam 250, Meflam 500, RefChem:5988, 200-513-1, Acid, Mefenamic, Apo Mefenamic, Nu Mefenamic, PMS Mefenamic Acid, Mefacit, Parkemed, Coslan, Ponalar, Bonabol, Bafameritin-M, Tamany Bonsan, Mefenamate, Pontal, Ponstan forte, Bafhameritin-M, 2-(2,3-Dimethylanilino)benzoic acid, Mefenacid, Namphen, Mefanamic acid, Ponstil, Ponstyl, HL 1, N-(2,3-Xylyl)anthranilic acid, AGN-1255, CL 473, MFCD00051721, NSC 94437, CI 473, CHEMBL686, MLS000069709, CAS-61-68-7, NCGC00016278-07, SMR000058188, Mefenaminsaeure [German], Ac. mefenamico [Italian], in-M, Acide mefenamique [French], Acide mefenamique [INN-French], Acido mefenamico [INN-Spanish], Acidum mefenamicum [INN-Latin], 2-(2,3-Xylidino)benzoic Acid, HSDB 3115, SR-01000000216, EINECS 200-513-1, BRN 2216243, mefenamic-acid, UNII-367589PJ2C, Mefenamic acid CRS, Prestwick_506, Anthranilic acid, N-(2,3-xylyl)-, Spectrum_000174, CPD000058188, Opera_ID_542, Mefenamic acid [USAN:USP:INN:BAN:JAN], Prestwick0_000054, Prestwick1_000054, Prestwick2_000054, Prestwick3_000054, Spectrum2_001941, Spectrum3_001082, Spectrum4_001235, Spectrum5_001341, M1782, Mefenamic acid (Standard), Anthranilic acid,3-xylyl-, Epitope ID:613441, cid_4044, SCHEMBL3544, MEFENAMIC ACID [MI], Oprea1_193889, BSPBio_000207, BSPBio_002724, KBioGR_001730, KBioSS_000654, MEFENAMIC ACID [INN], MEFENAMIC ACID [JAN], MLS001074162, DivK1c_000298, MEFENAMIC ACID [HSDB], MEFENAMIC ACID [USAN], SPECTRUM1501103, SPBio_002001, SPBio_002128, MEFENAMIC ACID [VANDF], BPBio1_000229, F0850-6853, GTPL2593, orb1310196, orb3025366, SGCUT00005, WLN: QVR BMR B1 C1, MEFENAMIC ACID [MART.], MEFENAMIC ACID [USP-RS], MEFENAMIC ACID [WHO-DD], SCHEMBL29350572, SCHEMBL29355128, SCHEMBL29465887, HMS500O20, HY-B0574R, KBio1_000298, KBio2_000654, KBio2_003222, KBio2_005790, KBio3_001944, BRD8217, MSK7159, NINDS_000298, GLXC-07949, HMS1568K09, HMS1921D13, HMS2090B07, HMS2092B17, HMS2095K09, HMS2232P18, HMS3259M19, HMS3370K18, HMS3652A10, HMS3712K09, HMS3885O22, HMS5082M08, Pharmakon1600-01501103, Mefenamic acid (JP18/USP/INN), Mefenamic acid, analytical standard, ALBB-025759, BRD-8217, HY-B0574, to_000071, Tox21_110344, Tox21_301983, BBL003564, BDBM50134036, CCG-39434, EBC-03713, MEFENAMIC ACID [ORANGE BOOK], MSK7159-100A, NSC757834, s4078, SBB056999, STK666691, MEFENAMIC ACID [EP MONOGRAPH], AKOS001025551, AKOS002388313, Benzoic acid,3-dimethylphenyl)amino]-, MEFENAMIC ACID [USP MONOGRAPH], MSK7159-1000A, Tox21_110344_1, DB00784, FM25038, NC00517, NSC-757834, IDI1_000298, SMP2_000141, 2-(2,3-Dimethylanilino)benzoic acid #, 2-(2,3-dimethylphenyl)aminobenzoic acid, NCGC00016278-01, NCGC00016278-02, NCGC00016278-03, NCGC00016278-04, NCGC00016278-05, NCGC00016278-06, NCGC00016278-10, NCGC00022393-03, NCGC00022393-04, NCGC00022393-05, NCGC00255401-01, AC-11160, AC-38318, AS-12677, ST086740, SY045797, SBI-0051636.P002, 2-(2,3-Dimethyl-phenylamino)-benzoic acid, 2-[(2,3-dimethylphenyl) amino]benzoic acid, 2-Diphenylaminecarboxylic acid,3'-dimethyl-, AB00052200, NS00000218, SW196700-3, UNM000001233403, EN300-16695, C02168, D00151, AB00052200-17, AB00052200_18, AB00052200_19, F079420, Mefenamic acid Solution in Acetonitrile, 100ug/mL, Q284321, Mefenamic acid Solution in Acetonitrile, 1000ug/mL, SR-01000000216-2, SR-01000000216-4, BRD-K92778217-001-06-1, BRD-K92778217-001-31-9, BRD-K92778217-001-32-7, Z56755828, 2-(2,3-Dimethyl-phenylamino)-benzoic acid(Mefenamic acid), Mefenamic Acid Working Standard (Secondary Reference Standard), Mefenamic acid, European Pharmacopoeia (EP) Reference Standard, Mefenamic acid, United States Pharmacopeia (USP) Reference Standard, InChI=1/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18
Theoretical properties:
molecular_formula: C15H15NO2
molecular_weight: 241.28 g/mol
exact_mass: 241.110278721 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 2
hydrogen_bond_acceptor_count: 3
rotatable_bond_count: 3
heavy_atom_count: 18
topological_polar_surface_area: 49.3 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
physical_state: CRYSTALS
color: CRYSTALS
melting_point: 230-231 °C
Descriptions:
pubchem: Mefenamic acid is an aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis. It has a role as a non-steroidal anti-inflammatory drug, an analgesic, an antipyretic, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, a xenobiotic, an antirheumatic drug and an environmental contaminant. It is an aminobenzoic acid and a secondary amino compound.
chebi: An aminobenzoic acid that is anthranilic acid in which one of the hydrogens attached to the nitrogen is replaced by a 2,3-dimethylphenyl group. Although classed as a non-steroidal anti-inflammatory drug, its anti-inflammatory properties are considered to be minor. It is used to relieve mild to moderate pain, including headaches, dental pain, osteoarthritis and rheumatoid arthritis.
chembl: MEFENAMIC ACID is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Mefenamic acid is a member of the anthranilic acid derivatives (or fenamate) class of nonsteroidal anti-inflammatory drugs (NSAIDs), and is used to treat mild to moderate pain.
Its name derives from its systematic name, dimethylphenylaminobenzoic acid. It was discovered and brought to market by Parke-Davis as Ponstel in the 1960s. It became generic in the 1980s and is available worldwide under many brand names such as Meftal.