Compound: Snc 80
SMILES: O=C(N(CC)CC)c1ccc([C@@H](N2[C@H](CN(CC=C)[C@@H](C2)C)C)c3cc(OC)ccc3)cc1
InChIKey: KQWVAUSXZDRQPZ-UMTXDNHDSA-N
Synonyms: Snc 80, 156727-74-1, Snc-80, SNC80, 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide, 4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enylpiperazin-1-yl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide, L842QB22SW, NIH-10815, 4-((R)-((2S,5R)-2,5-dimethyl-4-prop-2-enylpiperazin-1-yl)-(3-methoxyphenyl)methyl)-N,N-diethylbenzamide, RefChem:931887, DTXSID6045662, CHEMBL13470, 4-[(R)-[(2S,5R)-2,5-Dimethyl-4-(2-propen-1-yl)-1-piperazinyl](3-methoxyphenyl)methyl]-N,N-diethylbenzamide, 4-[(R)-[(2S,5R)-2,5-DIMETHYL-4-(PROP-2-EN-1-YL)PIPERAZIN-1-YL](3-METHOXYPHENYL)METHYL]-N,N-DIETHYLBENZAMIDE, NSC707484, Benzamide, 4-[(R)-[(2S,5R)-2,5-dimethyl-4-(2-propen-1-yl)-1-piperazinyl](3-methoxyphenyl)methyl]-N,N-diethyl-, NCGC00024777-02, DTXCID4025662, 4-[(R)-((2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl)-(3-methoxy-phenyl)-methyl]-N,N-diethyl-benzamide, CAS-156727-74-1, KQWVAUSXZDRQPZ-UMTXDNHDSA-N, NIH 10815, 4-((R)-((2S,5R)-2,5-DIMETHYL-4-(2-PROPEN-1-YL)-1-PIPERAZINYL)(3-METHOXYPHENYL)METHYL)-N,N-DIETHYLBENZAMIDE, BENZAMIDE, 4-((R)-((2S,5R)-2,5-DIMETHYL-4-(2-PROPEN-1-YL)-1-PIPERAZINYL)(3-METHOXYPHENYL)METHYL)-N,N-DIETHYL-, Tocris-0764, A1CLI, UNII-L842QB22SW, 4-((2,5-Dimethyl-4-(2-propenyl)-1-piperazinyl)(3-methoxyphenyl)methyl)-N,N-diethylbenzamide (2S-(1(S*),2alpha,5beta))-, SCHEMBL724753, GTPL1611, orb1298954, SCHEMBL29489341, CHEBI:109556, GLXC-22533, HMS3266B16, HMS3411H19, HMS3675H19, (+)-4-[(alphaR)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide, Tox21_110925, BDBM50039029, MFCD00672673, AKOS024458637, Tox21_110925_1, AT27894, FS27844, NSC-707484, NCGC00024777-01, NCGC00024777-03, NCGC00024777-04, NCGC00024777-08, 4-((R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl)(3-methoxyphenyl)methyl)-N,N-diethylbenzamide, 4-[(R)-[(2S,5R)-4-allyl-2,5-dimethyl-piperazin-1-yl]-(3-methoxyphenyl)methyl]-N,N-diethyl-benzamide, AS-74938, Benzamide, 4-((2,5-dimethyl-4-(2-propenyl)-1-piperazinyl)(3-methoxyphenyl)methyl)-N,N-diethyl-, (2S-(1(S*),2alpha,5bet))-, DA-77902, NCI60_038183, HY-101202, CS-0020978, SR-01000597706, Q7391803, SR-01000597706-1, BRD-K29546239-001-01-5, BRD-K29546239-001-02-3, 3-[(4-Allyl-2,5-dimethyl-piperazin-1-yl)-(4-diethylcarbamoyl-phenyl)-methyl]-benzoic acid, 4-[(4-Allyl-2,5-dimethyl-piperazin-1-yl)-(3-methoxy-phenyl)-methyl]-N,N-diethyl-benzamide, (+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl)(3-methoxyphenyl)methyl)-N,N-diethylbenzamide, (+)-4-[(?R)-?-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide, SNC 80, SNC-80, (+)-4-[(a-R)-a-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide, (+)-4-[(alpha-R)-alpha-[2S,5R]-4-allyl[2,5-dimethyl-1-piperazinyl]-3-methoxybenzyl]-N,N-diethylbenzamide, 4-((R)-((2R,5S)-4-allyl-2,5-dimethylpiperazin-1-yl)(3-methoxyphenyl)methyl)-N,N-diethylbenzamide, 4-[(4-Allyl-2,5-dimethyl-piperazin-1-yl)-(3-methoxy-phenyl)-methyl]-N,N-diethyl-benzamide (SNC 80), 4-[(4-Allyl-2,5-dimethyl-piperazin-1-yl)-(3-methoxy-phenyl)-methyl]-N,N-diethyl-benzamide(SNC-80), 4-[(R)-((2R,5S)-4-Allyl-2,5-dimethyl-piperazin-1-yl)-(3-methoxy-phenyl)-methyl]-N,N-diethyl-benzamide, 4-[(R)-((R)-4-(S)-Allyl-2,5-dimethyl-piperazin-1-yl)-(3-methoxy-phenyl)-methyl]-N,N-diethyl-benzamide, 4-[(R)-(4-Allyl-2,5-dimethyl-piperazin-1-yl)-(3-methoxy-phenyl)-methyl]-N,N-diethyl-benzamide, 4-[(R)-[(2S,5R)-4-allyl-2,5-dimethylpiperazin-1-yl](3-methoxyphenyl)-methyl]-N,N-diethylbenzamide
Theoretical properties:
molecular_formula: C28H39N3O2
molecular_weight: 449.6 g/mol
exact_mass: 449.30422750 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 4
rotatable_bond_count: 9
heavy_atom_count: 33
topological_polar_surface_area: 36 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: 4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enyl-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide is a diarylmethane.
chembl: SNC-80 is a small molecule listed in the ChEMBL database but has not progressed to an approved clinical phase.
wikipedia: SNC-80 is an opioid analgesic compound that selectively activates μ–δ opioid receptor heteromers and is used primarily in scientific research. Discovered in 1994, SNC-80 was a pioneering non-peptide compound regarded as a highly selective agonist for the δ-opioid receptor.
SNC-80 was the first non-peptide compound developed that was regarded as a highly selective agonist for the δ-opioid receptor.
It has been shown to produce useful analgesic, antidepressant and anxiolytic effects in animal studies, but its usefulness is limited by producing convulsions at high doses, and so SNC-80 is not used medically, although it is a useful compound in scientific research.