Compound: Levomethadone
SMILES: O=C(C(c1ccccc1)(c2ccccc2)C[C@H](N(C)C)C)CC
InChIKey: USSIQXCVUWKGNF-QGZVFWFLSA-N
Synonyms: Levomethadone, l-Methadone, Levothyl, (-)-Methadone, l-Polamivet, (R)-Methadone, (6R)-Methadone, Levometadona, Levadone, 125-58-6, D-(-)-Methadone, Levomethadonum, R-(-)-Methadone, Levomethadone [INN], (6R)-6-(dimethylamino)-4,4-diphenylheptan-3-one, METHADONE, L-, Levometadona [INN-Spanish], Levomethadonum [INN-Latin], 6Y75Z4E8NS, (R)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone, Levomethadone (INN), L-6-(Dimethylamino)-4,4-diphenyl-3-heptanone, (6R)-6-(dimethylamino)-4,4-diphenyl-3-heptanone, BRN 3213668, (-)-(R)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone, LEVOMETHADONE [WHO-DD], CHEBI:136003, DTXSID701016376, (R)-6-(Dimethylamino)-4,4-diphenyl-3-hetpanone, 3-14-00-00278 (Beilstein Handbook Reference), 3-heptanone, 6-(dimethylamino)-4,4-diphenyl-, (6R)-, 3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, (R)-, 3-HEPTANONE, 6-(DIMETHYLAMINO)-4,4-DIPHENYL-, L-, Levometadona (INN-Spanish), Levomethadonum (INN-Latin), (6R)-6-dimethylamino-4,4-di(phenyl)heptan-3-one, 3-Hetpanone, 6-(dimethylamino)-4,4-diphenyl-, (R)-, HEPTANONE, 6-(DIMETHYLAMINO)-4,4-DIPHENYL-, L-, R-methadone, (R)-(-)-methadone, RefChem:799027, N07BC05, DTXCID301474556, 3-Hetpanone, 6-(dimethylamino)-4,4-diphenyl-, (R)-(9CI), 603-081-6, UNII-6Y75Z4E8NS, (-)-(R)-Methadone, BIDD:PXR0190, SCHEMBL147864, CHEMBL159659, GTPL1605, BDBM50223633, PDSP1_000586, PDSP2_000583, DB13515, NS00117935, D08121, Q6535776, 3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, L- (8CI), 3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, (6R)- (9CI), 3-Hetpanone, 6-(dimethylamino)-4,4-diphenyl-, (R)- (9CI)
Theoretical properties:
molecular_formula: C21H27NO
molecular_weight: 309.4 g/mol
exact_mass: 309.209264485 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 7
heavy_atom_count: 23
topological_polar_surface_area: 20.3 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Levomethadone is a 6-(dimethylamino)-4,4-diphenylheptan-3-one that has (R)-configuration. It is the active enantiomer of methadone and its hydrochloride salt is used to treat adults who are addicted to drugs such as heroin and morphine. It has a role as an opioid analgesic, an antitussive, a mu-opioid receptor agonist and a NMDA receptor antagonist. It is an enantiomer of a dextromethadone.
chebi: A 6-(dimethylamino)-4,4-diphenylheptan-3-one that has (<i>R</i>)-configuration. It is the active enantiomer of methadone and its hydrochloride salt is used to treat adults who are addicted to drugs such as heroin and morphine.
chembl: LEVOMETHADONE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 2.0.
wikipedia: Levomethadone, sold under the brand name L-Polamidon among others, is a synthetic opioid analgesic and antitussive which is marketed in Europe and is used for pain management and in opioid maintenance therapy. In addition to being used as a pharmaceutical drug itself, levomethadone is also the main therapeutic component of methadone,  which is a racemic mixture of levomethadone (R-methadone) and dextromethadone (S-methadone).
Levomethadone is used for narcotic maintenance in place of, or in some cases alongside as an alternative, to racemic methadone, owing to concern that the cardiotoxic and QT-prolonging action of racemic methadone might be primarily caused by dextromethadone.