Compound: puromycin
SMILES: O=C(N[C@H]1[C@@H](O)[C@H](n2c3ncnc(c3nc2)N(C)C)O[C@@H]1CO)[C@@H](N)Cc4ccc(OC)cc4
InChIKey: RXWNCPJZOCPEPQ-NVWDDTSBSA-N
Synonyms: puromycin, 53-79-2, Stylomycin, Puromicina, Puromycine, Puromycinum, Stillomycin, P-638, 3123L, GNF-PF-2016, CL 13,900, CHEBI:17939, CL-13900, 4A6ZS6Q2CL, 3'-(L-alpha-Amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyladenosine, CL 13900, (S)-3'-((2-Amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-3'-deoxy-N,N-dimethyladenosine, DTXSID8036788, P 638, 3123-L, 3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine, Adenosine, 3'-((2-amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-3'-deoxy-N,N-dimethyl-, (S)-, CL 16536, (2S)-2-amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide, Adenosine, 3'-(alpha-amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyl-, L-, NSC3055, CL13900, (S)-3'-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine, (2S)-2-amino-N-((2S,3S,4R,5R)-5-(6-(dimethylamino)purin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl)-3-(4-methoxyphenyl)propanamide, RefChem:177304, DTXCID6016788, L-3'-(alpha-amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyladenosine, P638, Puromycin (USAN), PUROMYCIN [USAN], Adenosine, 3'-(((2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-3'-deoxy-N,N-dimethyl-, (S)-2-amino-N-((2S,3S,4R,5R)-5-(6-(dimethylamino)-9H-purin-9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)-3-(4-methoxyphenyl)propanamide, Achromycin (purine derivative), TCMDC-123493, 3'-deoxy-N,N-dimethyl-3'-[(O-methyl-L-tyrosyl)amino]adenosine, (2S)-2-amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl]-3-(4-methoxyphenyl)propanamide, 9-{3-deoxy-3-[(O-methyl-L-tyrosyl)amino]-beta-D-xylofuranosyl}-N,N-dimethyl-9H-purin-6-amine, NSC 3055, Puromycine [INN-French], Puromycinum [INN-Latin], Puromicina [INN-Spanish], UNII-4A6ZS6Q2CL, Bacterenomycin, Puromycin [USAN:INN:BAN], Achromycin;, Stillomycin;, Stylomycin;, C22H29N7O5, Adenosine, 3'-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-, PUY, Antibiotic 3123L;, Antibiotic P 638;, PUROMYCIN [INN], PUROMYCIN [MI], Prestwick3_000480, Epitope ID:140945, Antibiotic CL 13900;, PUROMYCIN [WHO-DD], SCHEMBL4570, BSPBio_000620, BPBio1_000682, CHEMBL469912, orb1705876, SCHEMBL29355751, GTPL13311, 3'-(L-.alpha.-Amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyladenosine, RXWNCPJZOCPEPQ-NVWDDTSBSA-N, HMS2089F18, AAA05379, HY-B1743, CL 16,536 (*Dihydrochloride*), BDBM50277158, EX-A13431, AKOS030485964, CCG-208505, CS-6500, DB08437, 6-Dimethylamino-9-(3'-(p-methoxy-L-phenylalanylamino)-beta-D-ribofuranosyl)-purine, NCGC00179500-01, NCGC00179500-07, NCGC00179500-14, AB00514661, NS00011702, C01610, D05653, G85883, AB00514661-07, Q424696, BRD-K36007650-001-01-9, BRD-K36007650-300-02-3, Q27167243, 3'-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-diemthyladenosine, (2S)-2-amino-N-[(2S,3S,4R,5R)-5-(6-dimethylaminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide, 2-amino-N-[5-[6-(dimethylamino)-9-purinyl]-4-hydroxy-2-(hydroxymethyl)-3-oxolanyl]-3-(4-methoxyphenyl)propanamide, Adenosine, 3'-(-amino-p-methoxyhydrocinnamamido)-3'-deoxy-N, N-dimethyl-, dihydrochloride, L-
Theoretical properties:
molecular_formula: C22H29N7O5
molecular_weight: 471.5 g/mol
exact_mass: 471.22301705 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 4
hydrogen_bond_acceptor_count: 10
rotatable_bond_count: 8
heavy_atom_count: 34
topological_polar_surface_area: 161 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
melting_point: 168°C-182°C
solubility: 50mg/ml
Descriptions:
pubchem: Puromycin is an aminonucleoside antibiotic, derived from the Streptomyces alboniger bacterium, that causes premature chain termination during translation taking place in the ribosome. It has a role as a nucleoside antibiotic, an antimicrobial agent, an antiinfective agent, an antineoplastic agent, a protein synthesis inhibitor, an EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor and an EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor. It is a conjugate base of a puromycin(1+).
chebi: An aminonucleoside antibiotic, derived from the <em>Streptomyces alboniger</em> bacterium, that causes premature chain termination during translation taking place in the ribosome.
chembl: PUROMYCIN is a small molecule listed in the ChEMBL database and has reached clinical trial phase 2.0.
wikipedia: Puromycin is an antibiotic protein synthesis inhibitor which causes premature chain termination during translation.