Compound: medrysone
SMILES: O=C1C=C2[C@]([C@H]3[C@@H](O)C[C@@]4([C@@H](C(=O)C)CC[C@H]4[C@@H]3C[C@@H]2C)C)(C)CC1
InChIKey: GZENKSODFLBBHQ-ILSZZQPISA-N
Synonyms: medrysone, 2668-66-8, Hydroxymesterone, U-8471, NSC-63278, 11beta-Hydroxy-6alpha-methylpregn-4-ene-3,20-dione, (6S,8S,9S,10R,11S,13S,14S,17S)-17-acetyl-11-hydroxy-6,10,13-trimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one, D2UFC189XF, DTXSID6045371, 6-alpha-Methyl-11-beta-hydroxyprogesterone, DTXCID4025371, NSC63278, 11-beta-Hydroxy-6-alpha-methylpregn-4-ene-3,20-dione, Pregn-4-ene-3,20-dione, 11-hydroxy-6-methyl-, (6alpha,11beta)-, HMS suspension, (1S,2R,8S,10S,11S,14S,15S,17S)-14-acetyl-17-hydroxy-2,8,15-trimethyltetracyclo(8.7.0.0^(2,7).0^(11,15))heptadec-6-en-5-one, (1S,2R,8S,10S,11S,14S,15S,17S)-14-acetyl-17-hydroxy-2,8,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one, (6S,8S,9S,10R,11S,13S,14S,17S)-17-acetyl-11-hydroxy-6,10,13-trimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta(a)phenanthren-3-one, RefChem:55563, 11-hydroxy-6-methylprogesterone, 220-208-7, Medrifar, Medrocort, Medritonic, Visudrisone, HMS Liquifilm, Medrisona, 6alpha-Methyl-11beta-hydroxyprogesterone, Medrysone (USAN), GSH 1043, MLS000028714, MLS001076155, U 8471, SMR000058693, MEDRYSONE [USAN], Medriabioptal, Medrysonum, Sedesterol, Spectramedryn, (6alpha,11beta)-11-hydroxy-6-methylpregn-4-ene-3,20-dione, Medrisone, Medriusar, Medroftal, Medrisone [DCIT], Medrysonum [INN-Latin], Medrisona [INN-Spanish], UNII-D2UFC189XF, Medrysone [USAN:USP:INN], 6|A-Methyl-11|A-hydroxyprogesterone, Prestwick_89, NCGC00016616-01, CAS-2668-66-8, EINECS 220-208-7, MFCD00056477, NSC 63278, Medrysone (Standard), 11beta-Hydroxy-6alpha-methylprogesterone, CPD000058693, MEDRYSONE [INN], Opera_ID_635, MEDRYSONE [MI], Prestwick0_000743, Prestwick1_000743, Prestwick2_000743, Prestwick3_000743, MEDRYSONE [VANDF], Progesterone, 11beta-hydroxy-6alpha-methyl-, 11.beta.-Hydroxy-6.alpha.-methylprogesterone, 6.alpha.-Methyl-11.beta.-hydroxyprogesterone, MEDRYSONE [MART.], HMS (TN), MEDRYSONE [WHO-DD], SCHEMBL4493, BSPBio_000726, MLS002207230, MLS002222162, SPBio_002665, BPBio1_000800, GTPL7086, orb1310110, MEDRYSONE [ORANGE BOOK], CHEMBL1201173, BCBcMAP01_000088, CHEBI:34829, HY-B1076R, 11.beta.-Hydroxy-6.alpha.-methylpregn-4-ene-3,20-dione, GZENKSODFLBBHQ-ILSZZQPISA-N, HMS1570E08, HMS2097E08, HMS2232F13, HMS3259A22, HMS3714E08, HY-B1076, Tox21_110526, EBC-26677, MSK011011, HMS;6-Methyl-11-hydroxyprogesterone, AKOS024285179, Pregn-4-ene-3,20-dione, 11-hydroxy-6-methyl-, (6.alpha.,11.beta.)-, Tox21_110526_1, CCG-220743, CS-4632, DB00253, MSK011011-100A, NC00599, 6|_-methyl-11|_-hydroxy Progesterone, SMP1_000061, MSK011011-1000A, NCGC00179460-01, NCGC00179460-03, (1S,3aS,3bS,5S,9aR,9bS,10S,11aS)-1-acetyl-10-hydroxy-5,9a,11a-trimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one, DA-75393, MS-25294, ST082266, NS00003836, Medrysone Solution in Acetonitrile, 100ug/mL, D02289, F85231, Medrysone Solution in Acetonitrile, 1000ug/mL, EN300-19631184, Progesterone, 11.beta.-hydroxy-6.alpha.-methyl-, SR-01000721900, Q6807292, SR-01000721900-3, BRD-K56515112-001-03-4, BRD-K56515112-001-21-6, Pregn-4-ene-3, 11.beta.-hydroxy-6.alpha.-methyl-, WLN: L E5 B666 OV MUTJ A1 CQ E1 FV1 L1, Pregn-4-ene-3,20-dione, 11beta-hydroxy-6alpha-methyl-, Pregn-4-ene-3,20-dione, 11-beta-hydroxy-6-alpha-methyl-, Medrysone, United States Pharmacopeia (USP) Reference Standard, Pregn-4-ene-3, 11-hydroxy-6-methyl-, (6.alpha.,11.beta.)-, (1S,8S,10S,11S,14S,15S,17S,2R)-14-acetyl-17-hydroxy-2,8,15-trimethyl-5-oxotetr acyclo[8.7.0.0<2,7>.0<11,15>]heptadec-6-ene, (6S,10R,11S,13S,17S)-17-acetyl-11-hydroxy-6,10,13-trimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one, (6S,8S,9S,10R,11S,13S,14S,17S)-17-acetyl-11-hydroxy-6,10,13-trimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one
Theoretical properties:
molecular_formula: C22H32O3
molecular_weight: 344.5 g/mol
exact_mass: 344.23514488 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 3
rotatable_bond_count: 1
heavy_atom_count: 25
topological_polar_surface_area: 54.4 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
solubility: 3.37e-02 g/L
Descriptions:
pubchem: Medrysone is a corticosteroid hormone.
chembl: MEDRYSONE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Medrysone (INN, USAN; brand names HMS, Medrocort, others; former developmental code NSC-63278; also known as hydroxymethylprogesterone, methylhydroxyprogesterone, hydroxymesterone, 6α-methyl-11β-hydroxyprogesterone, or 6α-methyl-11β-hydroxypregn-4-ene-3,20-dione) is a synthetic glucocorticoid that is or has been used in the treatment of inflammatory eye diseases. It has been discontinued in the United States. Although it is very similar in structure to progesterone, neither progestogenic nor androgenic activity has been demonstrated for or attributed to medrysone.