Compound: Propanidid
SMILES: O=C(OCCC)Cc1cc(OC)c(OCC(=O)N(CC)CC)cc1
InChIKey: KEJXLQUPYHWCNM-UHFFFAOYSA-N
Synonyms: Propanidid, 1421-14-3, Epontol, Propanidide, Bayer 1420, TH-2180, FBA 1420, Propanididum, WH 5668, BAYER-1420, DTXSID7048825, Benzeneacetic acid, 4-[2-(diethylamino)-2-oxoethoxy]-3-methoxy-, propyl ester, FBA-1420, WH-5668, AO82L471NS, Benzeneacetic acid, 4-(2-(diethylamino)-2-oxoethoxy)-3-methoxy-, propyl ester, DTXCID4028751, RefChem:389239, N01AX04, propyl 2-(4-((diethylcarbamoyl)methoxy)-3-methoxyphenyl)acetate, 215-822-7, Sombrevin, Fabantol, Propantan, Fabontal, BAY 1420, Fabantol;Propanidid, 2180 TH, Propyl(4-((diethylcarbamoyl)methoxy)-3-methoxyphenyl)acetate, (4-((Diethylcarbamoyl)methoxy)-3-methoxyphenyl)acetic acid propyl ester, (p-((Diethylcarbamoyl)methoxy)-3-methoxyphenyl)acetic acid propyl ester, 4-(2-(Diethylamino)-2-oxoethoxy)-3-methoxybenzeneacetic acid propyl ester, (3-Methoxy-4-((N,N-diethylcarbamido)methoxy)phenyl)acetic acid n-propyl ester, Acetic acid, (p-((diethylcarbamoyl)methoxy)-3-methoxyphenyl)-, propyl ester, NCGC00183027-01, propyl 2-[4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl]acetate, ACETIC ACID, (4-((DIETHYLCARBAMOYL)METHOXY)-3-METHOXYPHENYL)-, PROPYL ESTER, Propanidido, Propyl {4-((diethylcarbamoyl)methoxy)-3-methoxyphenyl}acetate, propyl 2-(4-(2-(diethylamino)-2-oxoethoxy)-3-methoxyphenyl)acetate, Propanidide [INN-French], Propanididum [INN-Latin], Propanidido [INN-Spanish], Propanidid [USAN:INN:BAN], EINECS 215-822-7, BRN 2952046, UNII-AO82L471NS, Eponthol, Propyl (4-[(diethylcarbamoyl)methoxy]-3-methoxyphenyl)acetate, Propyl {4-[(diethylcarbamoyl)methoxy]-3-methoxyphenyl}acetate, Epontol (TN), Propyl 4-((diethylcarbamoyl)methoxy)-3-methoxyphenyl acetate, PROPANIDID [MI], PROPANIDID [INN], Propanidid (USAN/INN), PROPANIDID [USAN], 13245 R. P., PROPANIDID [MART.], PROPANIDID [WHO-DD], SCHEMBL57661, orb1695599, propyl 4-diethylcarbamoylmethoxy-3-methoxyphenylacetate, CHEMBL2105345, CHEBI:135432, MSK11317, Tox21_113307, MFCD00390321, AKOS040753622, 13245RP, DB13234, CAS-1421-14-3, DB-256006, HY-116457, CS-0065537, NS00004551, D05626, H27793, Q409719, Propyl (4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl)acetate #, Propyl {4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl}acetate, [4-[(N,N-diethylcarbamoyl)methoxy]-3-methoxyphenyl]acetic Acid Propyl Ester, propyl 2-[4-[2-(diethylamino)-2-oxo-ethoxy]-3-methoxy-phenyl]acetate, [4-[(N,N-diethylcarbamoyl)methoxyl]-3-methoxyphenyl]acetic acid propyl ester
Theoretical properties:
molecular_formula: C18H27NO5
molecular_weight: 337.4 g/mol
exact_mass: 337.18892296 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 5
rotatable_bond_count: 11
heavy_atom_count: 24
topological_polar_surface_area: 65.1 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Propanidid is a member of methoxybenzenes.
chembl: PROPANIDID is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Propanidid is an ultra short-acting phenylacetate general anesthetic.  It was originally introduced by Bayer in 1963 but anaphylactic reactions caused it to be withdrawn shortly afterwards.
Even though Cremophor EL has been shown to cause anaphylactic reactions in humans in several cases (both when given intravenously and orally), it is still debated whether propanidid itself may have contributed to the reactions.
It has been argued that the toxic effects or reactions to propanidid (and Althesin) were due to the drugs themselves. Several cases of negative reactions have been recorded for different drugs using Cremophor EL as solubilizer, suggesting that the negative reactions were mainly caused by Cremophor and not by the drug substances themselves.