Compound: MEPHENTERMINE
SMILES: N(C(Cc1ccccc1)(C)C)C
InChIKey: RXQCGGRTAILOIN-UHFFFAOYSA-N
Synonyms: MEPHENTERMINE, Mephenterdrine, Mephenterdrinum, Mefenterdrin, Mefentermin, Mephetedrine, Mephine, Vialin, N-Methylphentermine, Wyfentermina, Wyamine, 100-92-5, Mefentermina, Mephenterminum, 2-Methylamino-2-methyl-1-phenylpropane, WY-585, N,alpha,alpha-Trimethylbenzeneethanamine, N-Methyl-omega-phenyl-t-butylamine, omega-Phenyl-tert-butyl-methylamine, N,alpha,alpha-Trimethylphenethylamine, N-Methyl-omega-phenyl-tert-butylamine, TEZ91L71V4, Phenethylamine, N,alpha,alpha-trimethyl-, methyl(2-methyl-1-phenylpropan-2-yl)amine, Benzeneethanamine, N,alpha,alpha-trimethyl-, CHEBI:6755, DTXSID4023256, RefChem:810992, DTXCID603256, C01CA11, 202-901-6, N,2-dimethyl-1-phenylpropan-2-amine, 2-Methyl-2-methylamino-1-phenylpropane, Mephentermine (INN), Benzeneethanamine, N,.alpha.,.alpha.-trimethyl-, (1,1-dimethyl-2-phenylethyl)methylamine, N,.alpha.,.alpha.-Trimethylphenethylamine, Phenethylamine, N,.alpha.,.alpha.-trimethyl-, MEPHENTERMINE [INN], Mephentermine [INN:BAN], Mefentermina [INN-Spanish], Mephenterminum [INN-Latin], N,2-dimethyl-1-phenylpropan-2-amine;N,2-dimethyl-1-phenylpropan-2-amine, HSDB 2172, NCGC00016570-01, EINECS 202-901-6, CAS-1212-72-2, BRN 1363850, UNII-TEZ91L71V4, Fentermin (Salt/Mix), Spectrum_001611, Prestwick0_000726, Prestwick1_000726, Prestwick2_000726, Prestwick3_000726, Spectrum2_000474, Spectrum3_001220, Spectrum4_000188, Spectrum5_001008, MEPHENTERMINE [MI], MEPHENTERMINE [HSDB], BSPBio_000652, BSPBio_002640, KBioGR_000735, KBioSS_002091, MEPHENTERMINE [VANDF], DivK1c_000229, SCHEMBL121178, SPBio_000608, SPBio_002591, MEPHENTERMINE [WHO-DD], BPBio1_000718, GTPL7222, CHEMBL1201234, BDBM81455, KBio1_000229, KBio2_002091, KBio2_004659, KBio2_007227, KBio3_002140, NINDS_000229, CAS_3677, NSC_3677, SBB015072, .omega.-Phenyl-tert-butyl-methylamine, N-Methyl-.omega.-phenyl-t-butylamine, AKOS006281398, DB01365, IDI1_000229, N,2-Dimethyl-1-phenyl-2-propanamine #, N-Methyl-.omega.-phenyl-tert-butylamine, NCGC00016570-02, NCGC00016570-03, ST075547, benzene, (2-methyl-2-methylamino)propyl-, SBI-0051802.P002, AB00053662, N,.alpha.,.alpha.-Trimethylbenzeneethanamine, NS00005281, C07889, D08180, AB00053662_08, N,.alpha.,.alpha.-Trimethyl-.beta.-phenethylamine, Q6817800, BRD-K18194590-065-05-6, BRD-K18194590-065-08-0
Theoretical properties:
molecular_formula: C11H17N
molecular_weight: 163.26 g/mol
exact_mass: 163.136099547 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 1
rotatable_bond_count: 3
heavy_atom_count: 12
topological_polar_surface_area: 12 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
physical_state: LIQUID
color: LIQUID
odor: FISHY AMINE ODOR
melting_point: < 25 °C
solubility: 1 G DISSOLVES IN 20 ML WATER, ABOUT 150 ML ETHANOL (95%); PRACTICALLY INSOL IN CHLOROFORM /SULFATE DIHYDRATE/
Descriptions:
pubchem: Mephentermine is a member of amphetamines.
chembl: MEPHENTERMINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Mephentermine, sold under the brand name Wyamine among others, is a sympathomimetic medication which was previously used in the treatment of low blood pressure but is mostly no longer marketed. It is used by injection into a vein or muscle, by inhalation, and by mouth.
Side effects of mephentermine include dry mouth, sedation, reflex bradycardia, arrhythmias, and hypertension. Mephentermine induces the release of norepinephrine and dopamine and is described as an indirectly acting sympathomimetic and psychostimulant. Its sympathomimetic effects are mediated by indirect activation of α- and β-adrenergic receptors. Chemically, it is a substituted phenethylamine and amphetamine and is closely related to phentermine and methamphetamine.
Mephentermine was first described and introduced for medical use by 1952. It was discontinued in the United States between 2000 and 2004. The medication appears to remain available only in India. Misuse of mephentermine for recreational and performance-enhancing purposes has been increasingly encountered in modern times, especially in India.