Compound: 8-OH-Dpat
SMILES: Oc1c2c(ccc1)CCC(C2)N(CCC)CCC
InChIKey: ASXGJMSKWNBENU-UHFFFAOYSA-N
Synonyms: 8-OH-Dpat, 78950-78-4, 8-HYDROXY-2-(DI-n-PROPYLAMINO)TETRALIN, 8-Hydroxy-DPAT, 7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol, 1-Naphthalenol, 7-(dipropylamino)-5,6,7,8-tetrahydro-, dl-8-Hydroxy-2-(dipropylamino)tetralin, IWS1724PX6, DTXSID30897384, CHEBI:73364, RefChem:388762, DTXCID00834185, DPAT, 1-Naphthalenol,7-(dipropylamino)-5,6,7,8-tetrahydro-, CHEMBL56, 7-(Dipropylamino)-5,6,7,8-tetrahydro-1-naphthalenol, [3H]-8-OH-DPAT, 80300-09-0, R(+)-8-OH-dpat, UNII-IWS1724PX6, (R)-8-Hydroxy-2-dipropylaminotetralin, (+-)-8-OH-DPAT, ASXGJMSKWNBENU-UHFFFAOYSA-N, 78950-78-4 (free base), 8-hydroxy-n,n-dipropyl-2-aminotetralin, 8OHDPAT, GTPL7, S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL  5-HT1A SECROT, Biomol-NT_000095, GTPL31, cid_1220, 8-OH-DPAT?, Lopac0_000576, SCHEMBL496783, BPBio1_001354, orb1690004, 8-Hydroxy-DPAT; 8OH-DPAT, 3-(dipropylamino)tetralin-5-ol, 8-OH-DPAT,(+), 8-OH-DPAT,(-), SCHEMBL29389900, BDBM21393, TQP0825, (+/-)-8-OH-DPAT, HMS3886N10, 8-OH-DPAT (8-Hydroxy-DPAT), 8-hydroxy-n,n-dipropylaminotetralin, EX-A2914, Internal sequencing standard peptide, MFCD00153811, PDSP1_000777, PDSP2_000765, AKOS030627213, CCG-204665, SDCCGSBI-0050558.P002, NCGC00015493-04, NCGC00015493-05, NCGC00015493-06, NCGC00015493-10, NCGC00024635-02, NCGC00024635-03, NCGC00024986-02, BO166474, MS-23507, DB-018083, DB-108186, HY-112061, (+/-)-8-Hydroxy-2-(dipropylamino)tetralin, CS-0043224, S8447, 8-Hydroxy-2-Dipropylaminotetralinehydrobromide, G12802, (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin, L000086, Q4644282, SR-01000075571-7, 5,6,7,8-tetrahydro-7-(dipropylamino)-1-naphthalenol, BRD-A48015106-001-01-0, BRD-A48015106-004-03-0, BRD-A48015106-004-08-9, (+/-)-8-HYDROXY-N,N-DIPROPYL-2-AMINOTETRALIN, 8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN, (+/-)-, (+/-)-7-(DIPROPYLAMINO)-5,6,7,8-TETRAHYDRO-1-NAPHTHALENOL, (+/-)-7-(Dipropylamino)-5,6,7,8-tetrahydro-1-naphthalenol; (+/-)-8-Hydroxy-2-(dipropylamino)tetralin(+/-)-8-Hydroxy-N,N-dipropyl-2-aminotetralin, 105558-30-3, 178036-65-2
Theoretical properties:
molecular_formula: C16H25NO
molecular_weight: 247.38 g/mol
exact_mass: 247.193614421 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 5
heavy_atom_count: 18
topological_polar_surface_area: 23.5 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: 8-OH-DPAT is a tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively. It has a role as a serotonergic antagonist. It is a member of phenols, a member of tetralins and a tertiary amino compound. It derives from a hydride of a tetralin.
chebi: A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively
chembl: 8-OH-DPAT is a small molecule listed in the ChEMBL database but has not progressed to an approved clinical phase.
wikipedia: 8-OH-DPAT, also known as 8-hydroxy-2-(dipropylamino)tetralin, is a serotonin 5-HT1A receptor agonist of the 2-aminotetralin family which was developed in the 1980s and has been widely used to study the function of the 5-HT1A receptor. It was one of the first major 5-HT1A receptor full agonists to have been discovered.
Originally believed to be selective for the 5-HT1A receptor, 8-OH-DPAT was later found to act as a serotonin 5-HT7 receptor agonist and serotonin reuptake inhibitor or releasing agent as well.
In animal studies, 8-OH-DPAT has been shown to possess antidepressant, anxiolytic, serenic (antiaggressive), anorectic, antiemetic,  hypothermic, hypotensive, bradycardic, hyperventilative, and analgesic effects.