Compound: IDAZOXAN
SMILES: O1c2c(OCC1C3=NCCN3)cccc2
InChIKey: HPMRFMKYPGXPEP-UHFFFAOYSA-N
Synonyms: IDAZOXAN, 79944-58-4, Idazoxano, Idazoxane, Idazoxanum, 2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole, Dl-idazoxan, Racemic idazoxan, DTXSID6045161, Y310PA316B, NSC-759867, CHEBI:5862, DTXCID4025161, RefChem:147691, 2-(2,3-dihydro-1,4-benzodioxin-3-yl)-4,5-dihydro-1H-imidazole, CHEMBL10316, NCGC00015560-06, 1H-Imidazole, 2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-, Idazoxane [French], Idazoxanum [Latin], Idazoxano [Spanish], 4,5-dihydro-2-(2,3-dihydro-1,4-benzodioxin-2-yl)-1H-imidazole, 2-(2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)-4,5-dihydro-1H-imidazole, CAS-79944-58-4, Idazoxan [INN:BAN], idasoxan, UNII-Y310PA316B, IDAZOXAN [INN], IDAZOXAN [MI], Prestwick0_000926, Prestwick1_000926, Prestwick2_000926, Prestwick3_000926, (+-)-2-(1,4-Benzodioxan-2-yl)-2-imidazoline, Lopac0_000652, US8633208, Idazoxan, (+/-)-IDAZOXAN, BSPBio_000832, TR-01-XRR, SCHEMBL114731, SPBio_003011, BPBio1_000916, orb2815651, SCHEMBL29368292, GTPL12575, HMS2089E14, Tox21 110173, Tox21_110173, 1H-Imidazole, 4,5-dihydro-2-(2,3-dihydro-1,4-benzodioxin-2-yl)-, BDBM50019848, 2-(1,4-benzodioxan-2-yl)imidazoline, AKOS015915004, Tox21_110173_1, CCG-204739, DB12551, NSC 759867, SDCCGSBI-0050632.P003, NCGC00015560-04, NCGC00015560-05, NCGC00015560-08, NCGC00015560-09, NCGC00015560-10, NCGC00015560-12, NCGC00015560-17, NCGC00024794-03, NCGC00024794-04, HY-14561, SBI-0050632.P002, AB00514632, CS-0003445, AB00489883-09, AB00489883_10, L000808, Q5987770, 2-IMIDAZOLINE, 2-(1,4-BENZODIOXAN-2-YL)-, BRD-A18696154-003-03-6, BRD-A18696154-003-14-3, BRD-A18696154-003-21-8, BRD-A18696154-003-22-6, (+/-)-2-(1,4-BENZODIOXAN-2-YL)-2-IMIDAZOLINE
Theoretical properties:
molecular_formula: C11H12N2O2
molecular_weight: 204.22 g/mol
exact_mass: 204.089877630 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 3
rotatable_bond_count: 1
heavy_atom_count: 15
topological_polar_surface_area: 42.9 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Idazoxan is a benzodioxine that is 2,3-dihydro-1,4-benzodioxine in which one of the hydrogens at position 2 has been replaced by a 4,5-dihydro-1H-imidazol-2-yl group. It has a role as an alpha-adrenergic antagonist. It is a member of imidazolines and a benzodioxine.
chebi: A benzodioxine that is 2,3-dihydro-1,4-benzodioxine in which one of the hydrogens at position 2 has been replaced by a 4,5-dihydro-1<em>H</em>-imidazol-2-yl group.
chembl: IDAZOXAN is a small molecule listed in the ChEMBL database and has reached clinical trial phase 3.0.
wikipedia: Idazoxan (INN) is a drug which is used in scientific research. It acts as both a selective α2-adrenergic receptor antagonist, and an antagonist for the imidazoline receptor. Idazoxan has been under investigation as an antidepressant, but it did not reach the market as such. More recently, it is under investigation as an adjunctive treatment in schizophrenia. Due to its α2 receptor antagonism, it is capable of enhancing therapeutic effects of antipsychotics, possibly by enhancing dopamine neurotransmission in the prefrontal cortex of the brain, a brain area thought to be involved in the pathogenesis of schizophrenia.