Compound: MIGLITOL
SMILES: O[C@H]1[C@H](O)[C@H](N(CCO)C[C@@H]1O)CO
InChIKey: IBAQFPQHRJAVAV-ULAWRXDQSA-N
Synonyms: MIGLITOL, 72432-03-2, Glyset, (2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol, Bay-m-1099, Bay m 1099, (2R,3R,4R,5S)-1-(2-Hydroxyethyl)-2-(hydroxymethyl)-3,4,5-piperidinetriol, 0V5436JAQW, DTXSID0023323, NSC-758702, DTXCID703323, 3,4,5-Piperidinetriol, 1-(2-hydroxyethyl)-2-(hydroxymethyl)-, (2R-(2alpha,3beta,4alpha,5beta))-, BAY-m 1099, N-hydroxyethyl-1-desoxynojirimycin, N-hydroxyethyl-1-desoxy-nojirimycin, RefChem:57016, MFCD00867240, Miglitol (Glyset), CHEMBL1561, Diastabol, Seibule, 3,4,5-Piperidinetriol, 1-(2-hydroxyethyl)-2-(hydroxymethyl)-,(2R,3R,4R,5S)-, Plumarol, Miglitolum, N-(2-Hydroxyethyl)-1-deoxynojirimycin, SMR000466381, Miglitolum [Latin], CAS-72432-03-2, Glyset (TN), UNII-0V5436JAQW, Miglitol [USAN:INN:BAN], BAY1099;BAY-m1099, Bay 1099, Diastabol;, HSDB 8022, NCGC00095127-01, EINECS 276-661-6, SK-983, baym1099, MIGLITOL [USAN], MIGLITOL [INN], MIGLITOL [JAN], MIGLITOL [MI], MIGLITOL [VANDF], GlyTouCan:G25287AB, MIGLITOL [MART.], MIGLITOL [WHO-DD], SCHEMBL22593, MLS000759514, MLS001424128, MLS006011963, BIDD:GT0732, MIGLITOL [ORANGE BOOK], CHEBI:6935, cid_441314, GTPL4842, Miglitol (JP18/USAN/INN), orb1308301, orb3141154, IBAQFPQHRJAVAV-ULAWRXDQSA-N, GLXC-06668, HMS2051D05, HMS3713J07, N-hydroxylethyl-1-deoxynojirimycin, G25287AB, HY-B0481, MSK10671, Tox21_111436, BDBM50242271, EBC-07366, N -Hydroxyethyl-1-desoxynojirimycin;, AKOS015969689, N-(b-Hydroxyethyl)-1-deoxynojirimycin, Tox21_111436_1, CCG-100920, DB00491, KS-1242, MH07215, NC00170, NSC 758702, NCGC00270540-02, SY068958, M2302, NS00004693, S2589, C07708, C76308, D00625, EN300-119541, AB00639982-06, AB00639982_08, F825537, Q772735, SR-01000759413, SR-01000759413-4, BRD-K44779798-001-06-5, Z1269163651, (2R,3R,4R,5S)-1-ethoxy-2-(hydroxymethyl)piperidine-3,4,5-triol, (4R,5R)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol, 1204250-58-7, 3,4,5-PIPERIDINETRIOL, 1-(2-HYDROXYETHYL)-2-(HYDROXYMETHYL)-, (2R-(2.ALPHA.,3.BETA.,4.ALPHA.,5.BETA.))-
Theoretical properties:
molecular_formula: C8H17NO5
molecular_weight: 207.22 g/mol
exact_mass: 207.11067264 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 5
hydrogen_bond_acceptor_count: 6
rotatable_bond_count: 3
heavy_atom_count: 14
topological_polar_surface_area: 104 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
physical_state: White to pale-yellow powder
color: White to pale-yellow powder
solubility: Soluble
Descriptions:
pubchem: Miglitol is a member of piperidines.
chembl: MIGLITOL is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Miglitol is an oral alpha-glucosidase inhibitor used in the treatment of type 2 diabetes. It works by reversibly inhibiting alpha-glucosidase enzymes in the small intestine, which delays the digestion of complex carbohydrates and subsequently reduces postprandial glucose levels. Approved for clinical use since 1998, miglitol has demonstrated efficacy in improving glycemic control, reducing HbA1c levels, and decreasing both fasting and postprandial plasma glucose concentrations in long-term clinical trials. Additionally, recent studies have suggested that miglitol may have potential as an anti-obesity agent, showing promise in reducing body weight and body mass index in obese or diabetic patients. While generally well-tolerated, the most common side effects associated with miglitol are gastrointestinal disturbances, which are typically mild to moderate and tend to decrease over time.
It must be taken at the start of main meals to have maximal effect
In contrast to acarbose (another alpha-glucosidase inhibitor), miglitol is systemically absorbed; however, it is not metabolized and is excreted by the kidneys.