Compound: CORTICOSTERONE
SMILES: O=C1C=C2[C@]([C@H]3[C@@H](O)C[C@@]4([C@@H](C(=O)CO)CC[C@H]4[C@@H]3CC2)C)(C)CC1
InChIKey: OMFXVFTZEKFJBZ-HJTSIMOOSA-N
Synonyms: CORTICOSTERONE, 50-22-6, 17-Deoxycortisol, Kendall's compound B, Reichstein's substance H, Corticosteron, 11beta,21-Dihydroxyprogesterone, (11beta)-11,21-Dihydroxypregn-4-ene-3,20-dione, 11Beta,21-dihydroxypregn-4-ene-3,20-dione, 11beta,21-Dihydroxy-4-pregnene-3,20-dione, NSC-9705, 4-Pregnene-11beta,21-diol-3,20-dione, DTXSID6022474, CHEBI:16827, W980KJ009P, (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one, DTXCID702474, (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta(a)phenanthren-3-one, RefChem:579253, 200-019-6, Reichstein's B, 11-Hydroxycorticoaldosterone, 11,21-Dihydroxyprogesterone, MFCD00037715, 11-beta,21-Dihydroxypregn-3,20-dione, NSC9705, 4-Pregnene-11-beta,21-diol-3,20-dione, Pregn-4-ene-3,20-dione, 11beta,21-dihydroxy-, Pregn-4-ene-3,20-dione, 11-beta,21-dihydroxy-, (11-beta)-11,21-Dihydroxypregn-4-ene-3,20-dione, MLS000028536, CHEMBL110739, 11.beta.,21-Dihydroxyprogesterone, NCGC00022472-05, SMR000058318, 4-Pregnene-11.beta.,21-diol-3,20-dione, Corticosterone 100 microg/mL in Acetonitrile, (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one, (11.beta.)-11,21-Dihydroxypregn-4-ene-3,20-dione, 11,12-Dihydroxyprogesterone, CCRIS 6753, 11-beta,21-Dihydroxyprogesterone, Compound B nach Kendall, SR-01000075748, NSC 9705, EINECS 200-019-6, Substanz H nach Reichstein, BRN 2339601, Cortico, UNII-W980KJ009P, Compd B, CAS-50-22-6, Prestwick_672, Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11b)-, 21-dihydroxyprogesterone, (11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONE, Opera_ID_1519, Prestwick0_000432, Prestwick1_000432, Prestwick2_000432, Prestwick3_000432, Corticosterone (Standard), Corticosterone, >=92%, 11-.beta.,20-dione, bmse000669, Epitope ID:152207, CORTICOSTERONE [MI], BIDD:PXR0063, Lopac0_000220, SCHEMBL22612, BSPBio_000444, 4-Pregnene-11 Corticosteron, MLS001074095, MLS001424305, Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11.beta.)-, BIDD:ER0495, SPBio_002383, BPBio1_000490, GTPL2869, orb1310140, orb3025742, HY-B1618R, Corticosterone, BRN 2339601, MSK8513, 4-Pregnene-11.beta.,20-dione, GLXC-08126, HMS1569G06, HMS2052G21, HMS2090A08, HMS2096G06, HMS2231F16, HMS3260L21, HMS3713G06, HMS3885H22, (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one, Corticosterone, 1mg/ml in Methanol, HY-B1618, Tox21_110879, Tox21_201366, Tox21_303642, Tox21_500220, BDBM50170653, CMC_13412, EBC-85062, HB2808, HSCI1_000383, LMST02030186, MSK8513-100A, s4752, STL564760, T0948L, Corticosterone, >=98.5% (HPLC), AKOS016008541, MSK8513-1000A, Tox21_110879_1, 11-b,21-Dihydroxypregn-3,20-dione, CCG-101146, CS-5105, DB04652, FC20555, LP00220, NC00396, SDCCGSBI-0050208.P002, SMP1_000079, NCGC00022472-06, NCGC00022472-07, NCGC00022472-08, NCGC00022472-10, NCGC00022472-17, NCGC00091029-01, NCGC00256539-01, NCGC00258918-01, NCGC00260905-01, 11|A, AS-75743, DA-52062, SY075891, 11,21-Dihydroxypregn-4-ene-3,20-dione, 11-.beta.,21-Dihydroxypregn-3,20-dione, 11b,21-Dihydroxy-4-pregnene-3,20-dione, Pregn-4-ene-3, 11.beta.,21-dihydroxy-, 4-Pregnen-11.beta.,21-diol-3,20-dione, EU-0100220, NS00000569, C 2505, C02140, D94656, Preg-4-ene-3,20-dione,11-b,21-dihydroxy-, 11.beta.,21-dihydroxypregn-4-ene-3,20-dione, Corticosterone Solution in Acetonitrile, 100ug/mL, Corticosterone, VETRANAL(TM), analytical standard, F235820, Q422543, SR-01000000082, (11|_)-11,21-Dihydroxypregn-4-ene-3,20-dione, (11b)-11,21-Dihydroxy-pregn-4-ene-3,20-dione, Corticosterone Solution in Acetonitrile, 1000ug/mL, Pregn-4-ene-3,20-dione, 11.beta.,21-dihydroxy-, SR-01000000082-3, SR-01000075748-1, SR-01000075748-4, WLN: L E5 B666 OV MUTJ A1 CQ E1 FV1Q, BRD-K73589401-001-04-6, BRD-K73589401-001-23-6, Pregn-4-ene-3, 11,21-dihydroxy-, (11.beta.)-, (9beta,11alpha)-11,21-dihydroxypregn-4-ene-3,20-dione, 11,21-Dihydroxypregn-4-ene-3,20-dione, (11.beta.)- #, 4793EB71-D789-498E-B641-C5C1C377B9FF, 17-Deoxycortisol;11,21-Dihydroxyprogesterone;Kendall's compound B, Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11-beta)- (9CI), Kendall's Compound B; 4-Pregnene-11beta,21-diol-3,20-dione; Reichstein's Substance H
Theoretical properties:
molecular_formula: C21H30O4
molecular_weight: 346.5 g/mol
exact_mass: 346.21440943 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 2
hydrogen_bond_acceptor_count: 4
rotatable_bond_count: 2
heavy_atom_count: 25
topological_polar_surface_area: 74.6 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
melting_point: 179 °C
solubility: 0.199 mg/mL
Descriptions:
pubchem: Corticosterone is a 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands. It has a role as a mouse metabolite and a human metabolite. It is a primary alpha-hydroxy ketone, a glucocorticoid, a 21-hydroxy steroid, an 11beta-hydroxy steroid, a 20-oxo steroid, a 3-oxo-Delta(4) steroid and a C21-steroid. It derives from a hydride of a pregnane.
chebi: A 21-hydroxy steroid that consists of pregn-4-ene substituted by hydroxy groups at positions 11 and 21 and oxo groups at positions 3 and 20. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.
chembl: CORTICOSTERONE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 3.0.
wikipedia: Corticosterone, also known as 17-deoxycortisol and 11β,21-dihydroxyprogesterone, is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.  In the very rare case of congenital adrenal hyperplasia due to 17α-hydroxylase deficiency cortisol production is blocked.