Compound: METOPON
SMILES: O=C1[C@@]2(Oc3c(O)ccc4c3[C@]25[C@H]([C@H](N(C)CC5)C4)CC1)C
InChIKey: NPZXCTIHHUUEEJ-CMKMFDCUSA-N
Synonyms: METOPON, Methyldihydromorphinone, 5-Methyldihydromorphinone, 143-52-2, 94XZ1CC69D, IDS-NM-006, DTXSID20162275, RefChem:158387, DTXCID1084766, Dihydro-6-methylmorphinone, Morphinone, methyldihydro-, Metopone [DCIT], Metopone, Metopon [INN:BAN], Metoponum, Metoponum [INN-Latin], 6-Methyldihydromorphinone, Morphinone, dihydro-6-methyl-, BRN 0044174, UNII-94XZ1CC69D, DEA No. 9260, Metopon (BAN), 4,5-alpha-Epoxy-3-hydroxy-5,17-diethylmorphinan-6-one, METOPON [INN], METOPON [MI], METOPON [WHO-DD], SCHEMBL25754, (5.alpha.)-4,5-Epoxy-3-hydroxy-5,17-dimethylmorphinan-6-one, CHEMBL2110992, Morphinan-6-one, 4,5-epoxy-3-hydroxy-5,17-dimethyl-, (5.alpha.)-, CHEBI:135267, Morphinan-6-one, 4,5-alpha-epoxy-3-hydroxy-5-beta-17-dimethyl-, NS00067959, D12690, Q2667888, 3-Hydroxy-5beta,17-dimethyl-4,5-epoxymorphinan-6-one
Theoretical properties:
molecular_formula: C18H21NO3
molecular_weight: 299.4 g/mol
exact_mass: 299.15214353 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 4
rotatable_bond_count: 0
heavy_atom_count: 22
topological_polar_surface_area: 49.8 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
{"pubchem": "Metopon is a morphinane alkaloid.", "chebi": null, "chembl": "METOPON is a small molecule listed in the ChEMBL database and has reached clinical trial phase 2.0.", "wikipedia": "Metopon (5-methylhydromorphone, CAS number 124-92-5) is an opioid analogue that is a methylated derivative of hydromorphone which was invented in 1929 as an analgesic.\nMetopon is sometimes used in medicine. Although longer acting than hydromorphone, metopon is less potent and its oral bioavailability is fairly low. Generally, metopon has few advantages to distinguish it from other, more commonly used opioid analgesics, although it does have a slightly lower tendency to produce nausea and respiratory depression compared to morphine.\nIn Canada, as of 1948, the hydrochloride of metopon (free base conversion ratio 0.891, molecular weight 335.8) was available only for oral administration for malignant pain and for maintenance of those habituated to morphine; the only dosage form available was singly scored 8 mg tablets.  It was manufactured by Parke, Davis, & Co., and was only for sale to doctors and hospitals.  Parke, Davis & Co. did not sell metopon to pharmacies.  It is unknown whether metopon tablets are still manufactured and sold in Canada.\nMetopon tablets, ampoules, and suppositories are available in Switzerland, Austria, Germany, and other countries in Continental Europe and the drug is used in Patient Controlled Analgesia pumps for severe chronic pain in particular.  Metopon is listed under Schedule II of the US Controlled Substances Act 1970, meaning it has an accepted medical use, but at this time it is not produced commercially and is seen only in laboratory research.  It did see some use in medicine \u2014 oncology in particular \u2014 in the US in the 1950s.  Currently metopon, which has a DEA ACSCN of 9260, does not have an annual manufacturing quota listed in the Federal Register and the bulk of the research on the drug at this time is taking place in Germany, Switzerland, and Austria."}