Compound: ALGESTONE ACETOPHENIDE
SMILES: O=C1C=C2[C@]([C@@H]3[C@H]([C@H]4[C@]([C@@]5(O[C@@](c6ccccc6)(C)O[C@@H]5C4)C(=O)C)(C)CC3)CC2)(C)CC1
InChIKey: AHBKIEXBQNRDNL-FVCOMRFXSA-N
Synonyms: ALGESTONE ACETOPHENIDE, Deladroxone, Droxone, Alphasone acetophenide, 24356-94-3, Dihydroxyprogesterone acetophenide, Algeston acetofenid, OL7KC2O3OT, SQ-15101, SQ 15,101, NSC-759863, SO-15101, DTXSID1022891, CHEBI:49327, Pregn-4-ene-3,20-dione, 16,17-((1-phenylethylidene)bis(oxy))-, (16alpha(R))-, (1R,2S,4R,6R,8S,9S,12S,13R)-8-acetyl-6,9,13-trimethyl-6-phenyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-16-one, (1R,2S,4R,6R,8S,9S,12S,13R)-8-acetyl-6,9,13-trimethyl-6-phenyl-5,7-dioxapentacyclo(10.8.0.02,9.04,8.013,18)icos-17-en-16-one, Acetophenide, Algestone, Acetophenide, Alphasone, RefChem:110685, DTXCID902891, Acetophenide, Dihydroxyprogesterone, 246-195-8, Algestone acetophenide [USAN], Algesterone acetophenide, (R)-16alpha,17-Dihydroxypregn-4-ene-3,20-dione cyclic acetal with acetophenone, algestone-acetophenide, Pregn-4-ene-3,20-dione, 16,17-[[(1R)-1-phenylethylidene]bis(oxy)]-,(16a)-, P-Dhp, UNII-OL7KC2O3OT, EINECS 246-195-8, SQ 15101, 16alpha,17alpha-Dihydroxyprogesterone acetophenone, SCHEMBL282250, 16-alpha,17-alpha-Dihydroxyprogesterone acetophenide, CHEMBL3989742, GLXC-20124, ALGESTONE ACETOPHENIDE [MI], 16alpha,17-((R)-1-Phenylethylidendioxy-4-pregnen-3,20-dion, 16-alpha,17-Dihydroxypregn-4-ene-3,20-dione cyclic acetal with acetophenone, AKOS032960373, ALGESTONE ACETOPHENIDE [MART.], ALGESTONE ACETOPHENIDE [WHO-DD], NSC 759863, SO 15,101, NS00027632, Q4724192, (R)-16alpha,17-((1-Phenylethylidene)dioxy)pregn-4-ene-3,20-dione, 16alpha,17-[(1R)-1-phenylethane-1,1-diyldioxy]pregn-4-ene-3,20-dione, PREGN-4-ENE-3,20-DIONE, 16,17-((1-PHENYLETHYLIDENE)BIS(OXY))-, (16.ALPHA.(R))-, Pregn-4-ene-3,20-dione, 16-alpha,17-dihydroxy-, cyclic acetal with acetophenone, (R)-, (4aR,4bS,6aS,6bS,8R,9aR,10aS,10bR)-6b-Acetyl-4a,6a,8-trimethyl-8-phenyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-2H,8H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, (4aR,4bS,6aS,6bS,8R,9aR,10aS,10bR)-6b-acetyl-4a,6a,8-trimethyl-8-phenyl-3,4,4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-tetradecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
Theoretical properties:
molecular_formula: C29H36O4
molecular_weight: 448.6 g/mol
exact_mass: 448.26135963 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 4
rotatable_bond_count: 2
heavy_atom_count: 33
topological_polar_surface_area: 52.6 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Algestone acetophenide is a 16alpha,17alpha-dihydroxyprogesterone acetophenide. It has a role as an anti-inflammatory drug and a synthetic oral contraceptive.
wikipedia: Algestone acetophenide, also known more commonly as dihydroxyprogesterone acetophenide (DHPA) and sold under the brand names Perlutal and Topasel among others, is a progestin medication which is used in combination with an estrogen as a form of long-lasting injectable birth control. It has also been used alone, but is no longer available as a standalone medication. DHPA is not active by mouth and is given once a month by injection into muscle.
Side effects of DHPA are similar to those of other progestins. DHPA is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has no other important hormonal activity.
DHPA was discovered in 1958 and was introduced for medical use in the 1960s. It was not introduced in the United States, but it is marketed widely throughout Latin America. It was also previously available alone in Italy and as a combined injectable contraceptive in Portugal and Spain, but has been discontinued in these countries.