Compound: protriptyline
SMILES: N(CCCC1c2c(C=Cc3c1cccc3)cccc2)C
InChIKey: BWPIARFWQZKAIA-UHFFFAOYSA-N
Synonyms: protriptyline, Protryptyline, Amimetilina, 438-60-8, Triptil, Protriptilina, Protriptylinum, 7-(3-Methylaminopropyl)-1,2:5,6-dibenzocycloheptatriene, N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine, N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine, 5-(3-Methylaminopropyl)-5H-Dibenzo[a,d]cycloheptene, N-3-(5H-Dibenzo(a,d)cyclohepten-5-yl)propyl-N-methylamine, 3-(5H-dibenzo[a,d][7]annulen-5-yl)-N-methylpropan-1-amine, N-Methyl-5H-dibenzo(a,d)cycloheptene-5-propylamine, 5-(3-Methylaminopropyl)-5H-dibenzo(a,d)cycloheptene, 4NDU154T12, 5H-Dibenzo(a,d)cycloheptene-5-propanamine, N-methyl-, 5H-Dibenzo(a,d)cycloheptene-5-propylamine, N-methyl-, CHEBI:8597, DTXSID0023535, 3-(5H-Dibenzo[a,d]cyclohepten-5-yl)-N-methyl-1-propanamine, 5H-Dibenzo[a,d]cycloheptene-5-propanamine, N-methyl-, 3-(11H-dibenzo[1,2-a:1',2'-e][7]annulen-11-yl)-N-methylpropan-1-amine, 5H-Dibenzo(a,d)cycloheptene-5-propanamine, N-methyl-, hydrochloride, N-methyl-5H-dibenzo(a,d)cycloheptene-5-propanamine, 5H-Dibenzo[a,d]cycloheptene-5-propylamine, N-methyl-, 3-(5H-dibenzo(a,d)(7)annulen-5-yl)-N-methylpropan-1-amine, 3-(5H-dibenzo(a,d)cyclohepten-5-yl)-N-methyl-1-propanamine, 3-(11H-dibenzo(1,2-a:1',2'-e)(7)annulen-11-yl)-N-methylpropan-1-amine, methyl(3-(tricyclo(9.4.0.0^(3,8))pentadeca-1(11),3(8),4,6,9,12,14-heptaen-2-yl)propyl)amine, methyl(3-{tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-2-yl}propyl)amine, RefChem:58088, Hydrochloride, Protriptyline, DTXCID203535, N06AA11, methyl(3-(tricyclo(9.4.0.03,8)pentadeca-1(15),3,5,7,9,11,13-heptaen-2-yl)propyl)amine, 207-119-9, N-Methyl-5H-dibenzo(a,d)cycloheptene-5-propylamine hydrochloride, Vivactil, Vivactyl, Protriptyline (INN), PROTRYPTYLINE HYDROCHLORIDE, CHEMBL668, N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaenyl)propan-1-amine, PROTRIPTYLINE [INN], Protriptyline [INN:BAN], Protriptylinum [INN-Latin], Protriptilina [INN-Spanish], HSDB 3391, NCGC00015851-02, EINECS 207-119-9, CAS-1225-55-4, BRN 2217411, UNII-4NDU154T12, Vivactil (Salt/Mix), Concordin (Salt/Mix), Prestwick0_000930, Prestwick1_000930, Prestwick2_000930, Prestwick3_000930, Lopac-P-8813, PROTRIPTYLINE [MI], PROTRIPTYLINE [HSDB], BIDD:PXR0157, Lopac0_000974, SCHEMBL34267, BSPBio_000840, PROTRIPTYLINE [VANDF], SPBio_003019, PROTRIPTYLINE [WHO-DD], BPBio1_000924, GTPL7285, orb1689592, SCHEMBL29374478, HY-B0949A, 5H-Dibenzo[a, d]cycloheptene-5-propanamine, N-methyl-, hydrochloride, BDBM50176062, EBC-26368, MK 240, PDSP1_001390, PDSP2_001374, AKOS015962184, CCG-205054, DB00344, SDCCGSBI-0050947.P003, NCGC00015851-01, NCGC00015851-03, NCGC00015851-04, NCGC00015851-05, NCGC00015851-06, NCGC00015851-07, NCGC00015851-15, NCGC00024439-03, AC-15971, DA-77173, SBI-0050947.P002, AB00489964, CS-0013761, NS00009004, C07408, D08447, AB00489964_10, EN300-18552820, L000913, Q408432, BRD-K42098891-003-03-1, BRD-K42098891-003-20-5, 3-(5H-Dibenzo[a,d]cyclohepten-5-yl)-N-methyl-1-propanamine #, 3-(11H-dibenzo[[?],[?]][7]annulen-11-yl)-N-methyl-propan-1-amine, methyl(3-{tricyclo[9.4.0.0,3,8]pentadeca-1(15),3,5,7,9,11,13-heptaen-2-yl}propyl)amine
Theoretical properties:
molecular_formula: C19H21N
molecular_weight: 263.4 g/mol
exact_mass: 263.167399674 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 1
rotatable_bond_count: 4
heavy_atom_count: 20
topological_polar_surface_area: 12 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
melting_point: 169-171 °C (Protriptyline HCl)
Descriptions:
pubchem: Protriptyline is a carbotricyclic compound. It has a role as an antidepressant. It derives from a hydride of a dibenzo[a,d][7]annulene.
chembl: PROTRIPTYLINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Protriptyline, sold under the brand name Vivactil among others, is a tricyclic antidepressant (TCA), specifically a secondary amine. Uniquely among most of the TCAs, protriptyline tends to be energizing instead of sedating, and is sometimes used for narcolepsy to achieve a wakefulness-promoting effect.
TCAs including protriptyline are also used to reduce the incidence of recurring headaches such as migraine, and for other types of chronic pain.