Compound: prednisolone
SMILES: O=C1C=C2[C@]([C@H]3[C@@H](O)C[C@@]4([C@@](O)(C(=O)CO)CC[C@H]4[C@@H]3CC2)C)(C)C=C1
InChIKey: OIGNJSKKLXVSLS-VWUMJDOOSA-N
Synonyms: prednisolone, 50-24-8, Metacortandralone, Hydroretrocortine, Deltacortril, Delta-Cortef, Codelcortone, Prenolone, Sterane, Deltahydrocortisone, Cortalone, Deltacortenol, Donisolone, Fernisolone, Hydrodeltalone, Paracortol, Hydeltra, Hydroretrocortin, Decortin H, Meti-Derm, Hydrodeltisone, Precortancyl, Predniliderm, Decaprednil, Delta F, Deltisilone, Dicortol, Estilsona, Hydeltrone, PRDL, Precortilon, Precortisyl, Prednelan, Prednicen, Scherisolon, Sterolone, Prelone, Steran, Ulacort, Delta-stab, Hostacortin H, Ultracorten H, Ultracortene-H, Predne-Dome, CO-Hydeltra, Eazolin D, Di-adreson F, Solone, Fernisolone-P, delta(1)-Hydrocortisone, delta(1)-Dehydrocortisol, Delta-Ef-Cortelan, Predniretard, 1-Dehydrohydrocortisone, Panafcortelone, Prednisolonum, 1,2-Dehydrohydrocortisone, 11beta,17,21-Trihydroxypregna-1,4-diene-3,20-dione, delta(1)-Cortisol, Deltasolone, Klismacort, Delta(1)-dehydrohydrocortisone, 1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione, (11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione, 1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol, 3,20-Dioxo-11beta,17alpha,21-trihydroxy-1,4-pregnadiene, 9PHQ9Y1OLM, APREDNISLON, EQUISOLON, (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one, DTXSID9021184, NSC-9120, NSC-9900, Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-, CHEBI:8378, DTXCID301184, Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-, NSC9120, Adnisolone, Deltidrosol, Kuhlprednon, Lenisolone, Longiprednil, Predeltilone, Prednicortelone, Scheriproct, Capsoid, Dekotil, Dhasolone, Dilacort, Fisopred, Frisolona, Gupisone, Opredsone, Pevanti, Prenilone, Precortisyl fte, PrednisTab, Delta-Phoricol, DiAdresonF, Lepi-Cortinolo, Dontisolon D, Predni-Coelin, Dacortin H, Delta-Diona, Pred-Clysma, Predni-Helvacort, Prednisolone oral, Meti Derm, Delta-F, Di Adreson F, Linola-H-Fett N, Linola-H N, (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta(a)phenanthren-3-one, delta1-Hydrocortisone, Delta(1)Hydrocortisone, RefChem:6161, prednisolone oral solution, Delta1-dehydro-hydrocortisone, Prednisolone anhydrous Micronized, 200-021-7, Cortisolone, Deltalone, Predonine, Predonin, Cotogesic, Delcortol, Dydeltrone, Erbacort, Erbasona, Lentosone, Paracotol, Rolisone, Cordrol, Prednis, Fernisolone P, Derpo PD, Prednisolona, Dexa-Cortidelt hostacortin H, Prednisolonum [INN-Latin], Prednisolona [INN-Spanish], Ultracortene-hydrogen, 11beta,17alpha,21-Trihydroxypregna-1,4-diene-3,20-dione, NSC 9120, K 1557, .DELTA.1-Cortisol, Prednisolone (Standard), .DELTA.1-Hydrocortisone, .DELTA.1-Dehydrocortisol, CHEMBL131, .DELTA.1-Dehydrohydrocortisone, .delta.-Cortef, Neo-Delta-Cortef, .delta.-Stab, MFCD00003649, component of Ataraxoid, Cotolone, component of K-Predne-Dome, (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one, Supercortisol, delta(sup 1)-Cortisol, Bubbli-Pred, Prednisolone (1.0 mg/mL in Methanol), delta(sup 1)-Hydrocortisone, delta(sup 1)-Dehydrocortisol, SMR000718761, CCRIS 980, Prednisolone [INN:BAN:JAN], HSDB 3385, delta(sup 1)-Dehydrohydrocortisone, Pregna-1,20-dione, 11.beta.,17,21-trihydroxy-, EINECS 200-021-7, UNII-9PHQ9Y1OLM, Predisolone Sodium Phosphate, BRN 1354103, prednisolon, Hydrocortisone EP Impurity A, Preflam, Pregna-1,20-dione, 11,17,21-trihydroxy-, (11.beta.)-, Delta-Cortef;, Prednisolone CRS, CAS-50-24-8, NCGC00094764-01, Prednisolone Powder, delta-hydrocortisone, 1-Dehydrocortisol;, TUA, Prestwick_404, delta-dehydrocortisol, DELTA.1-Cortisol, VETSOLONE, Delta-Cortef (TN), 11-beta,17,21-Trihydroxypregna-1,4-diene-3,20-dione, T-Pred (Salt/Mix), 1,4-Pregnadien-11-beta,17-alpha,21-triol-3,20-dione, 1,4-Pregnadiene-11-beta,17-alpha,21-triol-3,20-dione, 1,4-Pregnadiene-3,20-dione-11-beta,17-alpha,21-triol, Prednisolone, >=99%, Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, (11b)-, Prestwick0_000274, Prestwick1_000274, Prestwick2_000274, Prestwick3_000274, delta-dehydrohydrocortisone, PREDNISOLONE [EP], PREDNISOLONE [MI], (+)-PREDNISOLONE, PREDNISOLONE [INN], PREDNISOLONE [JAN], Prednisone impurity B CRS, EC 200-021-7, PREDNISOLONE [HSDB], SCHEMBL3233, K-Predne-Dome (Salt/Mix), PREDNISOLONE [VANDF], PREDNISOLONE ANHYDROUS, .DELTA.(sup 1)-Cortisol, BSPBio_000148, PREDNISOLONE [MART.], (1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one, 4-08-00-03467 (Beilstein Handbook Reference), MLS001304083, MLS002154250, MLS002207037, MLS002548883, PREDNISOLONE [USP-RS], PREDNISOLONE [WHO-DD], PREDNISOLONE [WHO-IP], SPBio_002367, BPBio1_000164, GTPL2866, US10196374, Prednisolone, SCHEMBL11040337, .DELTA.(sup 1)-Hydrocortisone, BDBM19190, Prednisolone (JP18/USP/INN), MSK2225, NSC9900, PREDNISOLONE [GREEN BOOK], .DELTA.(sup 1)-Dehydrocortisol, HMS1568H10, HMS2090J05, HMS2095H10, HMS2230P10, HMS3259E09, HMS3712H10, PREDNISOLONE [ORANGE BOOK], PREDNISOLONE [EP MONOGRAPH], PREDNISONE IMPURITY B [EP], NSC 9900, PREDNISOLONE [USP MONOGRAPH], Tox21_111327, Tox21_201673, Tox21_302987, EBC-12796, HY-17463R, LMST02030179, MSK2225-100A, MSK2225-100M, Prednisolone (1 mg/mL in Methanol), PREDNISOLONUM [WHO-IP LATIN], Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, (11.beta.)-, s1737, .DELTA.(sup 1)-Dehydrohydrocortisone, AKOS015894935, MSK2225-1000A, Tox21_111327_1, AC-1773, CCG-220274, DB00860, FP27131, NC00473, Prednisolone for system suitability CRS, Prednisolone for peak identification CRS, NCGC00179649-01, NCGC00179649-02, NCGC00179649-03, NCGC00179649-04, NCGC00179649-06, NCGC00256577-01, NCGC00259222-01, (1R,3aS,3bS,9aR,9bS,10S,11aS)-1,10-dihydroxy-1-(2-hydroxyacetyl)-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one, AS-13665, HY-17463, PREDNISOLONE (EMA EPAR: VETERINARY), CS-0695025, NS00000394, P0637, Prednisolone Solution in Methanol, 100ug/mL, EN300-53017, PREDNICARBATE IMPURITY A [EP IMPURITY], C07369, D00472, D91990, HYDROCORTISONE IMPURITY A [EP IMPURITY], Prednisolone Solution in Acetonitrile, 100ug/mL, Prednisolone, VETRANAL(TM), analytical standard, CHLOROPTIC-P S.O.P. COMPONENT PREDNISOLONE, METHYLPREDNISOLONE IMPURITY K [EP IMPURITY], Prednisolone Solution in Acetonitrile, 1000ug/mL, SR-01000837502, SR-01000837502-2, BRD-K98039984-001-03-0, BRD-K98039984-001-06-3, PREDNISOLONE ACETATE IMPURITY B [EP IMPURITY], Q11426176, 11beta,17,21-trihydroxy-1,4-pregnadiene-3,20-dione, Prednisolone, British Pharmacopoeia (BP) Assay Standard, Z778141968, 11-.beta.,17,21-Trihydroxypregna-1,4-diene-3,20-dione, (11?)-11,17,21-Trihydroxy-pregna-1,4-diene-3,20-dione, 1,4-Pregnadien-11-.beta.,17-.alpha.,21-triol-3,20-dione, 1,4-Pregnadiene-11-.beta.,17-.alpha.,21-triol-3,20-dione, 1,4-Pregnadiene-3,20-dione-11-.beta.,17-.alpha.,21-triol, Prednisolone, European Pharmacopoeia (EP) Reference Standard, Pregna-1,4-diene-3,20-dione, 11.beta.,17,21-trihydroxy-, 11,17,21-Trihydroxypregna-1,4-diene-3,20-dione, (11.beta.)-, 11-.beta.,17-.alpha.,21-Trihydroxy-1,4-pregnadiene-3,20-dione, 11-.beta.,17-.alpha.,21-Trihydroxypregna-1,4-diene-3,20-dione, 11.beta.,17.alpha.,21-Trihydroxypregna-1,4-diene-3,20-dione, Prednisolone, United States Pharmacopeia (USP) Reference Standard, Prednisolone for peak identification, European Pharmacopoeia (EP) Reference Standard, Prednisolone for system suitability, European Pharmacopoeia (EP) Reference Standard, Prednisolone, Pharmaceutical Secondary Standard; Certified Reference Material, (8S,9S,10R,11S,13S,14S,17R)-10,13-dimethyl-11,17-bis(oxidanyl)-17-(2-oxidanylethanoyl)-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one, 8056-11-9
Theoretical properties:
molecular_formula: C21H28O5
molecular_weight: 360.4 g/mol
exact_mass: 360.19367399 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 3
hydrogen_bond_acceptor_count: 5
rotatable_bond_count: 2
heavy_atom_count: 26
topological_polar_surface_area: 94.8 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
physical_state: Crystals
color: Crystals
odor: Odorless
Descriptions:
{"pubchem": "Prednisolone is a glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone. It has a role as an anti-inflammatory drug, an antineoplastic agent, a xenobiotic, an immunosuppressive agent, an adrenergic agent, a drug metabolite and an environmental contaminant. It is a primary alpha-hydroxy ketone, a tertiary alpha-hydroxy ketone, a glucocorticoid, a 17alpha-hydroxy steroid, a 21-hydroxy steroid, an 11beta-hydroxy steroid, a 20-oxo steroid, a C21-steroid and a 3-oxo-Delta(1),Delta(4)-steroid. It is functionally related to a Delta(1)-progesterone.", "chebi": "A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding \u03b2-hydroxy group. It is a drug metabolite of prednisone.", "chembl": "PREDNISOLONE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.", "wikipedia": "Prednisolone is a corticosteroid, a steroid hormone used to treat certain types of allergies, inflammatory conditions, autoimmune disorders, and cancers, electrolyte imbalances, and skin conditions. Some of these conditions include adrenocortical insufficiency, high blood calcium, rheumatoid arthritis, dermatitis, eye inflammation, asthma, multiple sclerosis, and phimosis. It can be taken by mouth, injected into a vein, used topically as a skin cream, or as eye drops.\nCommon side effects with short-term use include nausea, difficulty concentrating, insomnia, increased appetite, and fatigue. More severe side effects include psychiatric problems, which may occur in about 5% of people. Common side effects with long-term use include bone loss, weakness, yeast infections, and easy bruising. While short-term use in the later part of pregnancy is safe, long-term use or use in early pregnancy is occasionally associated with harm to the baby. It is a glucocorticoid made from hydrocortisone (cortisol).\nPrednisolone was discovered and approved for medical use in 1955. It is on the World Health Organization's List of Essential Medicines. It is available as a generic drug. In 2023, it was the 146th most commonly prescribed medication in the United States, with more than 3 million prescriptions.\n\n"}