Compound: estradiol cypionate
SMILES: O=C(O[C@@H]1[C@@]2([C@H]([C@H]3[C@@H](c4c(cc(O)cc4)CC3)CC2)CC1)C)CCC5CCCC5
InChIKey: UOACKFBJUYNSLK-XRKIENNPSA-N
Synonyms: estradiol cypionate, 313-06-4, Depo-Estradiol, Estradiol cipionate, Estradiol, 17-cyclopentanepropionate, NSC-3354, 7E1DV054LO, DTXSID4022999, 17beta-Estradiol 17-cyclopentylpropionate, NSC3354, Estradiol cypionate (USP), Estradiol cypionate [USP], DTXCID302999, Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 17-cyclopentanepropanoate, Estra-1,3,5(10)-triene-3,17-diol, (17beta)-, 17-cyclopentanepropanoate, RefChem:55136, ESTRADIOL 17beta-CYCLOPENTANEPROPANOATE, 206-237-8, Depofemin, Depoestradiol, Estradep, beta-Estradiol 17-cypionate, Depoestra, Estrapo, Estro-Depo, Dep-Estro, Depoestradiol cypionate, Femogen CYP, depGynogen, Estradiol 17-cypionate, Estradiol cyclopentylpropionate, Estradiol 17beta-cypionate, Estradiol (cypionate), E. Ionate P.A., Estradiol 17-cyclopentylpropionate, Depo-estradiol cyclopentylpropionate, NSC 3354, MFCD00056558, Cyclopentanepropionic acid, 17-ester with estradiol, 17.beta.-Estradiol cypionate, Estradiol 17.beta.-cypionate, Estradiol 17beta-cyclopentylpropionate, 17.beta.-Estradiol cyclopentylpropionate, Estradiol 17.beta.-cyclopentylpropionate, 17.beta.-Estradiol cyclopentanepropionate, Estradiol 17.beta.-cyclopentanepropanoate, Estradiol 17.beta.-cyclopentanepropionate, Pertradiol, 17.beta.-Estradiol 17-cyclopentylpropionate, Neoginon Depositum, [(8R,9S,13S,14S,17S)-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl] 3-cyclopentylpropanoate, ECP (VAN), (1S,11S,14S,15S,10R)-5-hydroxy-15-methyltetracyclo[8.7.0.0<2,7>.0<11,15>]hepta deca-2,4,6-trien-14-yl 3-cyclopentylpropanoate, (8R,9S,13S,14S,17S)-3-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl 3-cyclopentylpropanoate, CAS-313-06-4, SMR000058700, Estradiol 17-cyclopentanepropionate, EINECS 206-237-8, Estradiol 17beta-cylopentylpropionate, Estradiol 17beta-cyclopentanepropionate, BRN 3171075, UNII-7E1DV054LO, Depestro, Estra-1,3,5(10)-triene-3,17-diol (17.beta.)-, 17-cyclopentanepropanoate, estradiol-cypionate, NCGC00166134-01, Estradiol Cypionate salt, SCHEMBL41551, 4-09-00-00047 (Beilstein Handbook Reference), MLS000069763, MLS001074891, Estradiol cypionate (Standard), CHEMBL1200973, SCHEMBL29404977, CHEBI:34745, HY-B1100R, HMS2234K11, ESTRADIOL CYPIONATE [VANDF], ESTRADIOL CIPIONATE [MART.], HY-B1100, Tox21_110003, Tox21_112331, Tox21_301818, EBC-26935, Estra-1,3,5(10)-triene-3,17beta-diol 17-(cyclopentanepropionate), ESTRADIOL CIPIONATE [WHO-DD], ESTRADIOL CYPIONATE [USP-RS], ESTRADIOLI CYPIONAS [WHO-IP], s4046, |A-Estradiol 17-Cyclopentylpropionate, AKOS015895730, Cyclopentanepropionic acid, 3-hydroxyestra-1,3,5(10)-trien-17beta-yl ester, Tox21_112331_1, .BETA.-ESTRADIOL 17-CYPIONATE, beta-Estradiol 17-Cyclopentylpropionate, CCG-268613, CS-4691, DB13954, FE61563, KS-5296, Estradiol 17.beta.-cylopentylpropionate, |A- Estradiol-17-cyclopentyl propionate, ESTRADIOL CYPIONATE [ORANGE BOOK], NCGC00013034-01, NCGC00166134-02, NCGC00166134-03, NCGC00255333-01, (1S,3aS,3bR,9bS,11aS)-7-hydroxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl 3-cyclopentylpropanoate, NCI60_002938, ST075189, SY074853, ESTRADIOL CYPIONATE [USP MONOGRAPH], ESTRADIOL-17-CYCLOPENTANEPROPIONATE, LUNELLE COMPONENT ESTRADIOL CYPIONATE, E0875, NS00022039, D04063, DEPO-TESTADIOL COMPONENT ESTRADIOL CYPIONATE, EN300-19734590, Q5401760, ESTRADIOL 17.BETA.-CYCLOPENTANEPROPANOATE [MI], 3-Hydroxyestra-1(10),2,4-trien-17beta-yl 3-cyclopentylpropanoate, (17beta)-3-hydroxyestra-1(10),2,4-trien-17-yl 3-cyclopentylpropanoate, 17.beta.-[(3-Cyclopentylpropanoyl)oxy]estra-1,3,5(10)-trien-3-ol, Estra-1,5(10)-triene-3,17-diol (17.beta.)-, 17-cyclopentanepropanoate, Estra-1,5(10)-triene-3,17-diol, (17.beta.)-, 17-cyclopentanepropanoate, Estradiol cypionate, United States Pharmacopeia (USP) Reference Standard, (17.beta.)-Estra-1,3,5(10)-triene-3,17-diol 17.beta.-cyclopentanepropanoate, Cyclopentanepropionic acid, 3-hydroxyestra-1,3,5(10)-trien-17.beta.-yl ester, Estra-1,3,5(10)-triene-3,17-diol, (17.beta.)-, 17-cyclopentanepropanoate
Theoretical properties:
molecular_formula: C26H36O3
molecular_weight: 396.6 g/mol
exact_mass: 396.26644501 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 3
rotatable_bond_count: 5
heavy_atom_count: 29
topological_polar_surface_area: 46.5 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Estradiol 17beta-cyclopentylpropionate is a steroid ester.
chembl: ESTRADIOL CYPIONATE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Estradiol cypionate (EC), sold under the brand name Depo-Estradiol among others, is an estrogen medication which is used in hormone therapy for menopausal symptoms and low estrogen levels in women, in hormone therapy for trans women, and in hormonal birth control for women. It is given by injection into muscle once every 1 to 4 weeks.
Side effects of estradiol cypionate include breast tenderness, breast enlargement, nausea, headache, and fluid retention. Estradiol cypionate is an estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol. Estradiol cypionate is an estrogen ester and a long-lasting prodrug of estradiol in the body. Because of this, it is considered to be a natural and bioidentical form of estrogen.
Estradiol cypionate was first described as well as introduced for medical use in 1952. Along with estradiol valerate, it is one of the most commonly used esters of estradiol. Estradiol cypionate has mostly been used in the United States, but is also marketed in a few other countries. The medication is not available in Europe. It is not currently available as a generic medication in the United States.