Compound: isradipine
SMILES: O=C(OC(C)C)C1=C(NC(C)=C(C1c2c3nonc3ccc2)C(=O)OC)C
InChIKey: HMJIYCCIJYRONP-UHFFFAOYSA-N
Synonyms: isradipine, 75695-93-1, DynaCirc, Lomir, Prescal, Dynacirc CR, PN 200-110, Isradipino, PN-200-110, Isradipinum, DTXSID4023179, NSC-759892, YO1UK1S598, 3,5-Pyridinedicarboxylic acid, 4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester, 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester, DTXCID203179, O5-methyl O3-propan-2-yl 4-(2,1,3-benzoxadiazol-7-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, 3,5-Pyridinedicarboxylic acid, 4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester, (+-)-, 3-methyl 5-propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, PN 205-033, PN-205-034, isradipina, PN205033, PN205034, PN 205033, PN 205034, PN 205 033, PN 205 034, RefChem:56439, C08CA03, Isopropyl methyl(+-)-4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate, Isradipin, Isrodipine, Esradin, Clivoten, Dynacrine, Isradipinum [Latin], Isradipino [Spanish], Rebriden, DynaCire, DynaCire CR, 3-isopropyl 5-methyl 4-(benzo[c][1,2,5]oxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, (+/-)-Isradipine, Isradipine (Dynacirc), PN 200, 3-O-methyl 5-O-propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, MFCD00153820, (+-)-Isradipine, 131970-21-3, Icaz, SMR000466320, SMR002529690, DynaCirc (TN), Isradipine (USP/INN), SR-01000597526, UNII-YO1UK1S598, Isradipine CRS, Isradipine [USAN:USP:INN:BAN], NCGC00016931-01, Isradipine; Methyl 1-methylethyl (4RS)-4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, (plusmn)-isradipine, CAS-75695-93-1, PN200-110, Isopropyl methyl (+-)-4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate, Isradipine (Standard), Spectrum_000218, ISRADIPINE [MI], PN-200110, ISRADIPINE [INN], Prestwick0_001021, Prestwick1_001021, Prestwick2_001021, Prestwick3_001021, (.+/-.)-Isradipine, ISRADIPINE [USAN], ISRADIPINE [VANDF], ISRADIPINE [MART.], CHEMBL1648, ISRADIPINE [USP-RS], ISRADIPINE [WHO-DD], SCHEMBL34555, BSPBio_001201, KBioSS_000698, 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methylethyl ester, MLS000759425, MLS001424076, MLS002154106, MLS003915633, MLS006010138, SPBio_003062, BPBio1_001323, CHEBI:6073, CHEMBL315436, GTPL4488, orb1310131, CHEMBL3211306, ISRADIPINE [ORANGE BOOK], HY-B0233R, KBio2_000698, KBio2_003266, KBio2_005834, ISRADIPINE [EP MONOGRAPH], GLXC-06803, HMS1571M03, HMS2051J12, HMS2098M03, HMS2235O12, HMS3268D21, HMS3393J12, HMS3413A15, HMS3655C17, HMS3677A15, HMS3715M03, HMS3753I21, HMS3884E06, HMS5079L08, ISRADIPINE [USP MONOGRAPH], Pharmakon1600-02300234, HY-B0233, MSK10708, Benzo[1,2,5]oxadiazol-4-aldehyde, Tox21_110690, BDBM50436176, EBC-11193, HB1223, NSC759892, s1662, AKOS015895129, Isradipine for peak identification CRS, Isradipine, >=98% (HPLC), solid, Tox21_110690_1, AC-8539, CCG-101027, CCG-213711, DB00270, FI24738, HS-0085, NC00277, NSC 759892, Isopropyl Methyl 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate, NCGC00025341-01, NCGC00025341-02, NCGC00025341-03, NCGC00025341-06, 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester (9CI), 4-(2,1,3-Benzooxadiazol-4-yl)-2.6-dimethyl-1,4-dihydro-3-isopropyloxycarbonylpyridine-5-carboxylic Acid Methyl Ester, 4-(4-Benzofurazanyl)-1,-4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methhylethyl ester, 4-(4-Benzofurazanyl)-1,-4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methylethyl ester, 4-(4-Benzofurazanyl)-1,4-dihydro-2,-6-dimethyl-3,5-pyridinedicarboxylic acid methyl 1-methylethyl ester, isopropyl 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-5-methoxycarbonyl-2,6-dimethyl-3-pyridinecarboxylate, methyl 1-methylethyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, O5-isopropyl O3-methyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, PD002963, PD033063, DB-055981, DB-230560, AB00514007, I0876, NS00004669, SW220017-1, A12823, D00349, SBI-0634304.0001, AB00514007_02, AB00514007_03, EN300-19741623, F047201, Q414873, SR-01000597526-1, SR-01000597526-2, SR-01000597526-8, BRD-A90799790-001-03-3, BRD-A90799790-001-10-8, BRD-A90799790-001-16-5, BRD-A90799790-001-17-3, BRD-A90799790-001-19-9, Isradipine, European Pharmacopoeia (EP) Reference Standard, Isradipine, United States Pharmacopeia (USP) Reference Standard, Isopropyl Methyl 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimet, 3,5-PYRIDINEDICARBOXYLIC ACID, 4-(4-BENZOFURAZANYL)-1,4-DIHYDRO-2,6-DIMETHYL-, METHYL 1-METHYLETHYL ESTER, (+/-)-, 3,5-Pyridinedicarboxylic acid, 4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester, (.+/-.)-, 3-Isopropyl 5-methyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate #, 4-(2,1,3-Benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydro-3-isopropyloxycarbonyl-pyridine-5-carboxylic acid methyl ester, 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Isopropyl Methyl Ester, ISOPROPYL METHYL (+/-)-4-(4-BENZOFURAZANYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATE, Isopropyl methyl (.+/-.)-4-(4-benzfurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate, Isopropyl methyl (.+/-.)-4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate, Isopropyl methyl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate, Methyl propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Theoretical properties:
molecular_formula: C19H21N3O5
molecular_weight: 371.4 g/mol
exact_mass: 371.14812078 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 8
rotatable_bond_count: 6
heavy_atom_count: 27
topological_polar_surface_area: 104 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
melting_point: 168-170 °C
solubility: Practically insoluble (< 10 mg/L at 37 °C)
Descriptions:
pubchem: Isradipine is a methyl ester, an isopropyl ester, a benzoxadiazole and a dihydropyridine.
chembl: ISRADIPINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Isradipine (tradenames DynaCirc, Prescal) is a calcium channel blocker of the dihydropyridine class. It is usually prescribed for the treatment of high blood pressure in order to reduce the risk of stroke and heart attack.
It was patented in 1978 and approved for medical use in 1989.