Compound: desipramine
SMILES: N1(c2c(cccc2)CCc3c1cccc3)CCCNC
InChIKey: HCYAFALTSJYZDH-UHFFFAOYSA-N
Synonyms: desipramine, Norimipramine, 50-47-5, Desmethylimipramine, Monodemethylimipramine, Desipramin, Demethylimipramine, Desimipramine, Dimethylimipramine, Dezipramine, Desipramina, Methylaminopropyliminodibenzyl, Imipramine, demethyl-, desipraminum, Desimpramine, 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE, N-(3-Methylaminopropyl)iminobibenzyl, Desipramine (D4), 5-(gamma-Methylaminopropyl)iminodibenzyl, DMI 50475, N-desmethylimipramine, 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methylpropan-1-amine, TG537D343B, DTXSID6022896, CHEBI:47781, 5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(methylamino)propyl)-, Pertrofran, Apo Desipramine, Nu Desipramine, 3-(5,6-dihydrobenzo(b)(1)benzazepin-11-yl)-N-methylpropan-1-amine, 5H-Dibenz[b,f]azepine, 10,11-dihydro-5-[3-(methylamino)propyl]-, Novo Desipramine, PMS Desipramine, 3-(10,11-dihydro-5H-dibenzo(b,f)azepin-5-yl)-N-methylpropan-1-amine, Ratio Desipramine, (3-(2-azatricyclo(9.4.0.0^(3,8))pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl)propyl)(methyl)amine, (3-{2-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl}propyl)(methyl)amine, RefChem:54946, DTXCID902896, N06AA01, (3-(2-azatricyclo(9.4.0.03,8)pentadeca-1(15),3,5,7,11,13-hexaen-2-yl)propyl)(methyl)amine, 200-040-0, Norpramine, Sertofran, DMI (pharmaceutical), Desipramine (INN), CHEMBL72, 10,11-Dihydro-5-(3-methylaminopropyl)-5H-dibenz(b,f)azepine, 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N-methyl-, 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N-methyl-, (3-{2-azatricyclo[9.4.0.0,3,8]pentadeca-1(15),3,5,7,11,13-hexaen-2-yl}propyl)(methyl)amine, (3-(10H,11H-Dibenzo[b,f]azepin-5-yl)propyl)methylamine, Pertrofane, DESIPRAMINE [INN], Desipramine [INN:BAN], Desipraminum [INN-Latin], Desipramina [INN-Spanish], Desmethylimipramine;Imipramine,demethyl-;Methylaminopropyliminodibenzyl, CCRIS 7091, HSDB 3052, CAS-58-28-6, NCGC00015340-02, EINECS 200-040-0, BRN 1432747, Treyzafagit, UNII-TG537D343B, Imipramine-M Nor, Desipramine;Norpramin, Desipramine Free Base, Pertofran (Salt/Mix), Spectrum_000441, Pertofrane (Salt/Mix), IMIPRAMINE_met001, DESIPRAMINE [MI], Prestwick0_000343, Prestwick1_000343, Prestwick2_000343, Prestwick3_000343, Spectrum2_000091, Spectrum3_000379, Spectrum4_000314, Spectrum5_000833, Lopac-D-3900, DESIPRAMINE [HSDB], DESIPRAMINE [VANDF], Lopac0_000358, SCHEMBL34384, BSPBio_000405, BSPBio_002137, DESIPRAMINE [WHO-DD], KBioGR_000928, KBioSS_000921, DivK1c_000190, SPBio_000042, SPBio_002326, BPBio1_000447, GTPL2399, orb1689578, SCHEMBL29379525, BDBM35229, HY-B1272A, KBio1_000190, KBio2_000921, KBio2_003489, KBio2_006057, KBio3_001357, NINDS_000190, 10, 11-Dihydro-N-methyl-5H-dibez[b,f]azepine-5-propanamine, HMS3430H03, HMS3742I19, ALBB-025959, 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N-methyl-propan-1-amine, EBC-13575, SBB002569, STK735144, AKOS001681456, CCG-118231, CS-8193, DB01151, SDCCGSBI-0050346.P005, IDI1_000190, NCGC00015340-01, NCGC00015340-03, NCGC00015340-04, NCGC00015340-05, NCGC00015340-06, NCGC00015340-07, NCGC00015340-08, NCGC00015340-09, NCGC00015340-10, NCGC00015340-11, NCGC00015340-13, NCGC00015340-22, NCGC00024375-04, AC-15977, ST052019, SBI-0050346.P004, AB00053450, NS00010406, C06943, D07791, AB00053450_14, EN300-18293453, L001089, Q423288, BRD-K60762818-003-15-3, BRD-K60762818-003-25-2, BRD-K60762818-003-26-0, IMIPRAMINE HYDROCHLORIDE IMPURITY A [EP IMPURITY], 5-(3-methylaminopropyl)-10,11-dihydro-5H-dibenzo[b,f]azepine, 5H-Dibenz[b,f]azepine, 10,11-dihydro-5-(methylamino)propyl-, 10,11-dihydro-5-(3-(methylamino)propyl)-5h-dibenz(b,f)azepine, 5H-Dibenzo[b, f]azepine, N-(3-methylaminopropyl)-, 10,11-Dihydro, 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-methyl-1-propanamine #, 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl);-N-methylpropan-1-amine, N-[3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]-N-methylamine
Theoretical properties:
molecular_formula: C18H22N2
molecular_weight: 266.4 g/mol
exact_mass: 266.178298710 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 4
heavy_atom_count: 20
topological_polar_surface_area: 15.3 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
boiling_point: 172-174 °C @ 0.02 MM HG
melting_point: 214-218 °C
Descriptions:
pubchem: Desipramine is a dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group. It has a role as an antidepressant, an adrenergic uptake inhibitor, an alpha-adrenergic antagonist, a H1-receptor antagonist, a cholinergic antagonist, a serotonin uptake inhibitor, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor, an EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor and a drug allergen. It is a dibenzoazepine and a secondary amino compound.
chebi: A dibenzoazepine consisting of 10,11-dihydro-5<em>H</em>-dibenzo[<em>b</em>,<em>f</em>]azepine substituted on nitrogen with a 3-(methylamino)propyl group.
chembl: DESIPRAMINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Desipramine, sold under the brand name Norpramin among others, is a tricyclic antidepressant (TCA) used in the treatment of depression. It acts as a relatively selective norepinephrine reuptake inhibitor, though it does also have other activities such as weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects. The drug has not been considered a first-line treatment for depression since the introduction of selective serotonin reuptake inhibitor (SSRI) antidepressants, which have fewer side effects and are safer in overdose.