Compound: Astromicin
SMILES: O=C(N([C@@H]1[C@@H](OC)[C@@H](O)[C@H](N)[C@H]([C@@H]1O)O[C@H]2O[C@H]([C@@H](N)C)CC[C@H]2N)C)CN
InChIKey: BIDUPMYXGFNAEJ-APGVDKLISA-N
Synonyms: Astromicin, Fortimicin A, 55779-06-1, Astromicina, Astromicine, Antibiotic KW-1070, Astromicinum, ASTM, XK-70-1, KW 1070, XK 70-1, 7JHD84H15J, DTXSID2022624, KW-1070, 4-Amino-1-((aminoacetyl)methylamino)-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-6-O-methyl-L-chiro-inositol, DTXCID602624, CHEBI:37923, 2-amino-N-[(1S,2R,3R,4S,5S,6R)-4-amino-3-[(2R,3R,6S)-3-amino-6-[(1S)-1-aminoethyl]oxan-2-yl]oxy-2,5-dihydroxy-6-methoxycyclohexyl]-N-methylacetamide, 4-amino-1-(2-amino-N-methylacetamido)-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-6-O-methyl-L-chiro-inositol, N-[(1S,2R,3R,4S,5S,6R)-4-amino-3-({(2R,3R,6S)-3-amino-6-[(1S)-1-aminoethyl]tetrahydro-2H-pyran-2-yl}oxy)-2,5-dihydroxy-6-methoxycyclohexyl]-N-methylglycinamide, 2-amino-N-((1S,2R,3R,4S,5S,6R)-4-amino-3-((2R,3R,6S)-3-amino-6-((1S)-1-aminoethyl)oxan-2-yl)oxy-2,5-dihydroxy-6-methoxycyclohexyl)-N-methylacetamide, N-((1S,2R,3R,4S,5S,6R)-4-amino-3-(((2R,3R,6S)-3-amino-6-((1S)-1-aminoethyl)tetrahydro-2H-pyran-2-yl)oxy)-2,5-dihydroxy-6-methoxycyclohexyl)-N-methylglycinamide, RefChem:115364, astromycin, Astromicin [INN], Astromicin (INN), Abbott 44747, Astromicin A, Astromicine [INN-French], Astromicinum [INN-Latin], Astromicina [INN-Spanish], UNII-7JHD84H15J, NCGC00185750-01, FORTIMICIN A [MI], ASTROMICIN [WHO-DD], SCHEMBL158389, orb1698305, CHEMBL3084803, Tox21_113387, AKOS040750610, CAS-55779-06-1, HY-123162, CS-0081586, NS00011544, C17708, D07470, Q4811598, (1R,2S,3S,4R,5S,6R)-2-amino-5-[glycyl(methyl)amino]-3,6-dihydroxy-4-(methyloxy)cyclohexyl 2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranoside, (1R,2S,3S,4R,5S,6R)-2-Amino-5-[glycyl(methyl)amino]-3,6-dihydroxy-4-methoxycyclohexyl 2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranoside, 2-Amino-N-((1S,2R,3R,4S,5S,6R)-4-amino-3-(((2R,3R,6S)-3-amino-6-((S)-1-aminoethyl)tetrahydro-2H-pyran-2-yl)oxy)-2,5-dihydroxy-6-methoxycyclohexyl)-N-methylacetamide, L-chiro-Inositol, 4-amino-1-((aminoacetyl)methylamino)-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-6-O-methyl-
Theoretical properties:
molecular_formula: C17H35N5O6
molecular_weight: 405.5 g/mol
exact_mass: 405.25873385 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 6
hydrogen_bond_acceptor_count: 10
rotatable_bond_count: 6
heavy_atom_count: 28
topological_polar_surface_area: 193 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Astromicin is an amino cyclitol glycoside that is L-chiro-inositol in which the hydroxy groups at positions 1, 4, and 6 are replaced by aminoacetyl)methylamino, amino, and methoxy groups, respectively, and in which the hydroxy group at position 3 is converted to the corresponding 2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranoside. The major component of fortimicin, obtained from Micromonospora olivasterospora. It is administered (as the sulfate salt) by intramuscular injection or intravenous infusion for the treatment of severe systemic infections due to sensitive Gram-negative organisms. It has a role as a metabolite and an antibacterial agent. It is an amino cyclitol glycoside, an aminoglycoside antibiotic, a diol, a monocarboxylic acid amide and a primary amino compound.
chebi: An amino cyclitol glycoside that is <small>L</small>-<em>chiro</em>-inositol in which the hydroxy groups at positions 1, 4, and 6 are replaced by aminoacetyl)methylamino, amino, and methoxy groups, respectively, and in which the hydroxy group at position 3 is converted to the corresponding 2,6-diamino-2,3,4,6,7-pentadeoxy-β-<small>L</small>-<i>lyxo</i>-heptopyranoside. The major component of fortimicin, obtained from <em>Micromonospora olivasterospora</em>. It is administered (as the sulfate salt) by intramuscular injection or intravenous infusion for the treatment of severe systemic infections due to sensitive Gram-negative organisms.
chembl: ASTROMICIN is a small molecule listed in the ChEMBL database and has reached clinical trial phase 2.0.
wikipedia: Astromicin (INN; also frequently referenced in scientific journal articles as fortimicin A/B) is an aminoglycoside antibiotic. It is produced by Micromonospora olivasterospora (also named with additional o in olivoasterospora).