Compound: etazolate
SMILES: O=C(OCC)c1c(NN=C(C)C)c2c(n(CC)nc2)nc1
InChIKey: OPQRBXUBWHDHPQ-UHFFFAOYSA-N
Synonyms: etazolate, 51022-77-6, Etazolato, Etazolatum, EHT-0202, I89Y79062L, 1H-Pyrazolo(3,4-b)pyridine-5-carboxylic acid, 1-ethyl-4-((1-methylethylidene)hydrazino)-, ethyl ester, DTXSID4048434, CHEBI:138502, ethyl 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)pyrazolo[4,5-e]pyridine-5-carboxylate, ethyl 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)pyrazolo(4,5-e)pyridine-5-carboxylate, RefChem:137999, DTXCID0028408, Etazolate [INN], ethyl 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)pyrazolo[3,4-b]pyridine-5-carboxylate, ethyl 1-ethyl-4-(2-isopropylidenehydrazino)pyrazolo[3,4-b]pyridine-5-carboxylate, 1H-Pyrazolo[3,4-b]pyridine-5-carboxylicacid, 1-ethyl-4-[2-(1-methylethylidene)hydrazinyl]-, ethyl ester, hydrochloride(1:1), Etazolatum [INN-Latin], Etazolato [INN-Spanish], Ethyl 1-ethyl-4-(2-(propan-2-ylidene)hydrazineyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate, Ethyl 1-ethyl-4-[2-(1-methylethylidene)hydrazino]-1H-pyrazolo[3,4-b]pyridine-5-carboxylate, NSC163611, SQ 20,009, UNII-I89Y79062L, Tocris-0438, Lopac-E-1896, ethyl 1-ethyl-4-(2-isopropylidenehydrazino)-1h-pyrazolo[3,4-b]pyridine-5-carboxylate, Lopac0_000440, Etazolate hydrochloride(USAN), SCHEMBL123840, GTPL7336, orb1740309, SCHEMBL29824913, CHEBI:93135, EHT-202, OPQRBXUBWHDHPQ-UHFFFAOYSA-N, HMS2090J08, Tox21 111226, BDBM50225504, HSCI1_000299, CCG-204532, FE22846, SB16896, SDCCGSBI-0050425.P002, NCGC00015403-01, NCGC00015403-02, NCGC00015403-03, NCGC00015403-04, NCGC00024590-01, NCGC00024590-02, ethyl 1-ethyl-4-[2-(propan-2-ylidene)hydrazin-1-yl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylate, SQ-20,009, NS00120481, AB01275529-01, Q5402458, BRD-K64755930-003-01-6, BRD-K64755930-003-02-4, BRD-K64755930-003-03-2, ETHYL 1-ETHYL-4-(ISOPROPYLIDENEHYDRAZINO)-1H-PYRAZOLO(3,4-B)PYRIDINE-5-CARBOXYLATE, 1-ethyl-4-(2-propan-2-ylidenehydrazinyl)-5-pyrazolo[3,4-b]pyridinecarboxylic acid ethyl ester, 1-Ethyl-4-(N'-isopropylidene-hydrazino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester, 1-Ethyl-4-[2-(1-methylethylidene)hydrazinyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic Acid Ethyl Ester
Theoretical properties:
molecular_formula: C14H19N5O2
molecular_weight: 289.33 g/mol
exact_mass: 289.15387487 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 6
rotatable_bond_count: 6
heavy_atom_count: 21
topological_polar_surface_area: 81.4 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Etazolate is a pyrazolopyridine that is 1H-pyrazolo[3,4-b]pyridine which is substituted at positions 1, 4, and 5 by ethyl, 2-isopropylidenehydrazino, and ethoxycarbonyl groups, respectively. A phosphodiesterase IV inhibitor with antidepressant and anxiolytic properties. It has a role as an antidepressant, an anxiolytic drug, an antipsychotic agent, a GABA agent, a neuroprotective agent, a phosphodiesterase IV inhibitor and an alpha-secretase activator. It is an ethyl ester, a hydrazone and a pyrazolopyridine.
chebi: A pyrazolopyridine that is 1<em>H</em>-pyrazolo[3,4-<em>b</em>]pyridine which is substituted at positions 1, 4, and 5 by ethyl, 2-isopropylidenehydrazino, and ethoxycarbonyl groups, respectively. A phosphodiesterase IV inhibitor with antidepressant and anxiolytic properties.
chembl: ETAZOLATE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 2.0.
wikipedia: Etazolate (SQ-20,009, EHT-0202) is an anxiolytic drug which is a pyrazolopyridine derivative and has unique pharmacological properties. It acts as a positive allosteric modulator of the GABAA receptor at the barbiturate binding site, as an adenosine antagonist of the A1 and A2 subtypes, and as a phosphodiesterase inhibitor selective for the PDE4 isoform. It is currently in clinical trials for the treatment of Alzheimer's disease.