Compound: GUANETHIDINE
SMILES: N(=C(N)N)CCN1CCCCCCC1
InChIKey: ACGDKVXYNVEAGU-UHFFFAOYSA-N
Synonyms: GUANETHIDINE, 55-65-2, Abapresin, Sanotensin, Eutensol, Oktadin, Octatensine, Oktatensin, Oktatenzin, Dopom, Guanetidina, Octadine, Guanethidinum, 2-(1'-Azacyclooctyl)ethylguanidine, N-(2-Perhydroazocin-1-ylethyl)guanidine, Azocine, 1-(2-guanidinoethyl)octahydro-, 2-(1-N,N-Heptamethyleneimino)ethylguanidine, Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-, (2-(Octahydro-1-azocinyl)ethyl)guanidine, 1-[2-(azocan-1-yl)ethyl]guanidine, 2-[2-(azocan-1-yl)ethyl]guanidine, Heptamethylenimine, 1-(2-guanidinoethyl)-, ZTI6C33Q2Q, 1-(2-(Azocan-1-yl)ethyl)guanidine, Azocine, 1-((2-(aminoiminomethyl)amino)ethyl)octahydro-, CHEBI:5557, DTXSID5023116, (2-(hexahydro-1(2h)-azocinyl)ethyl)guanidine, Guanidine, [2-(hexahydro-1(2H)-azocinyl)ethyl]-, [2-(Octahydro-1-azocinyl)ethyl]guanidine, 2-(2-(azocan-1-yl)ethyl)guanidine, [2-(Hexahydro-1(2H)-azocinyl)ethyl]guanidine, Azocine, 1-[[2-(aminoiminomethyl)amino]ethyl]octahydro-, ((2-Hexahydro-1(2H)-azocinyl)ethyl)guanidine, RefChem:5873, DTXCID203116, C02CC02, S01EX01, 200-241-3, Ismelin, Dopam, Octatensin, Isobarin, Octadin, N-[2-(azocan-1-yl)ethyl]guanidine, Guanethidine Sulphae, Guanethidine (INN), Guanetidin sulfate, 1-(2-azocan-1-ylethyl)guanidine, Guanethidine (sulfate), Su 5864 sulfate (1:1), GUANETHIDINE [INN], Guanethidine [INN:BAN], Guanethidinum [INN-Latin], Guanetidina [INN-Spanish], Guanidine, N-[2-(hexahydro-1(2H)-azocinyl)ethyl]-, HSDB 3092, CAS-60-02-6, NCGC00016272-01, EINECS 200-241-3, UNII-ZTI6C33Q2Q, Octatenzine, 3h-guanethidine, Iporal (Salt/Mix), Isobarin (Salt/Mix), Spectrum_000837, Prestwick0_000317, Prestwick1_000317, Prestwick2_000317, Prestwick3_000317, Spectrum2_001103, Spectrum3_000446, Spectrum4_000568, Spectrum5_000784, GUANETHIDINE [MI], CHEMBL765, GUANETHIDINE [HSDB], GUANETHIDINE [VANDF], SCHEMBL34753, SCHEMBL34754, BSPBio_000314, BSPBio_002092, KBioGR_000976, KBioSS_001317, SU 5864 (Salt/Mix), DivK1c_000539, GUANETHIDINE [WHO-DD], SPBio_001206, SPBio_002533, BPBio1_000346, GTPL7194, orb1909040, KBio1_000539, KBio2_001317, KBio2_003885, KBio2_006453, KBio3_001312, NINDS_000539, HY-B1251, STR07524, .Beta.-1-Azacyclooctylethylguanidine, EBC-12252, MFCD20542855, STK895063, AKOS005614041, N-[2-(1-Azocanyl)ethyl]guanidine #, CCG-213488, DB01170, IDI1_000539, N''-[2-(azocan-1-yl)ethyl]guanidine, NCGC00016272-02, NCGC00016272-03, NCGC00247765-01, SBI-0051399.P003, amino(2-azaperhydroocinylethyl)carboxamidine, AB00053479, CS-0013044, NS00001475, ST45025913, C07036, D08030, EN300-123310, AB00053479_04, AB00053479_05, L000732, Q420673, BRD-K62676709-001-01-9, BRD-K62676709-065-05-5, Z1198152903
Theoretical properties:
molecular_formula: C10H22N4
molecular_weight: 198.31 g/mol
exact_mass: 198.18444672 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 2
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 3
heavy_atom_count: 14
topological_polar_surface_area: 67.6 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
melting_point: 276-281
solubility: Very soluble
Descriptions:
pubchem: Guanethidine is a member of the class of guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group. It has a role as an antihypertensive agent, an adrenergic antagonist and a sympatholytic agent. It is a member of guanidines and a member of azocanes. It is functionally related to a guanidine. It derives from a hydride of an azocane.
chebi: A member of the class of  guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group.
chembl: GUANETHIDINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Guanethidine is an antihypertensive drug that reduces the release of catecholamines, such as norepinephrine. Guanethidine is transported across the sympathetic nerve membrane by the same mechanism that transports norepinephrine itself (NET, uptake 1), and uptake is essential for the drug's action. Once guanethidine has entered the nerve, it is concentrated in transmitter vesicles, where it replaces norepinephrine. It may also inhibit the release of granules by decreasing norepinephrine.