Compound: mianserin
SMILES: N12c3c(cccc3)Cc4c(C1CN(C)CC2)cccc4
InChIKey: UEQUQVLFIPOEMF-UHFFFAOYSA-N
Synonyms: mianserin, Mianserine, 24219-97-4, Mianserina, Mianserinum, Tolvon, 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo(c,f)pyrazino(1,2-a)azepine, 250PJI13LM, DTXSID6023317, J16.389I, CHEBI:51137, 5-methyl-2,5-diazatetracyclo[13.4.0.0^{2,7}.0^{8,13}]nonadeca-1(19),8,10,12,15,17-hexaene, DTXCID003317, Dibenzo(c,f)pyrazino(1,2-a)azepine, 1,2,3,4,10,14b-hexahydro-2-methyl-, 1,2,3,4,10,14b-hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine, Dibenzo[c,f]pyrazino[1,2-a]azepine, 1,2,3,4,10,14b-hexahydro-2-methyl-, 1,2,3,4,10,14B-HEXAHYDRO-2-METHYLDIBENZO(C,F)-PYRAZINO(1,2-A)AZEPINE, 5-methyl-2,5-diazatetracyclo[13.4.0.0^{2,7}.0^{8,13}]nonadeca-1(15),8(13),9,11,16,18-hexaene, 5-methyl-2,5-diazatetracyclo(13.4.0.0^(2,7).0^(8,13))nonadeca-1(15),8(13),9,11,16,18-hexaene, 5-methyl-2,5-diazatetracyclo(13.4.0.0^(2,7).0^(8,13))nonadeca-1(19),8,10,12,15,17-hexaene, RefChem:158482, N06AX03, 246-088-6, Mianseryna [Polish], Mianseryna, Mianserine [INN-French], Mianserinum [INN-Latin], Mianserina [INN-Spanish], 2-Methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine, Mianserin (INN), CHEMBL6437, NCGC00015656-06, MIANSERIN [INN], Mianserin [INN:BAN], 5-methyl-2,5-diazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(19),8,10,12,15,17-hexaene, CAS-24219-97-4, Tolvon (TN), (+/-)-Mianserin, HSDB 7182, EINECS 246-088-6, BRN 0755346, UNII-250PJI13LM, mianserin a, Mianserin?, S(+)-Mianserin, (+-)-Athymil, Spectrum_001810, PS32 -  Mianserin, MIANSERIN [MI], MIANSERIN [HSDB], Prestwick0_000099, Prestwick1_000099, Prestwick2_000099, Prestwick3_000099, Spectrum2_001203, Spectrum3_001836, Spectrum4_001260, Spectrum5_001772, MIANSERIN [VANDF], Biomol-NT_000135, MIANSERIN [WHO-DD], Lopac0_000744, Oprea1_703627, SCHEMBL18020, BSPBio_000058, BSPBio_003511, GTPL135, KBioGR_001820, KBioSS_002303, cid_68551, DivK1c_000844, SPBio_000986, SPBio_001997, BPBio1_000064, BPBio1_000331, orb1705061, SCHEMBL29356897, BDBM31005, KBio1_000844, KBio2_002301, KBio2_004869, KBio2_007437, KBio3_003016, NINDS_000844, HMS2089A04, BCA15288, HY-B0188, Tox21_110191, AC-631, BDBM50222218, EBC-26370, PDSP1_001532, PDSP2_001516, AKOS005216268, Tox21_110191_1, CCG-204829, CS-2078, DB06148, SDCCGSBI-0050722.P004, IDI1_000844, NCGC00015656-04, NCGC00015656-05, NCGC00015656-08, NCGC00015656-09, NCGC00015656-10, NCGC00015656-12, NCGC00015656-23, NCGC00024926-03, NCGC00024926-04, DA-65446, TS-08152, SBI-0050722.P003, NS00010650, D08216, EN300-18559884, L000736, Q416701, BRD-A19661776-001-01-5, BRD-A19661776-003-05-2, BRD-A19661776-003-16-9, BRD-A19661776-003-25-0, BRD-A19661776-003-26-8, BRD-A19661776-003-27-6, BRD-A19661776-003-28-4, 2-Methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine #, Dibenzo[c,f]pyrazino[1,2-a]azepine, 1,2,3,4,10,14b-hexahydro-2-methyl-; 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine; (+/-)-Mianserin; Mianserin; Mianserine
Theoretical properties:
molecular_formula: C18H20N2
molecular_weight: 264.4 g/mol
exact_mass: 264.162648646 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 0
heavy_atom_count: 20
topological_polar_surface_area: 6.5 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
solubility: 2.32e-01 g/L
Descriptions:
pubchem: Mianserin is a dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere. It has a role as a geroprotector, an antidepressant, an adrenergic uptake inhibitor, a histamine agonist, a sedative, an alpha-adrenergic antagonist, a H1-receptor antagonist, a serotonergic antagonist and an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor.
chebi: A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[<em>c</em>,<em>f</em>]pyrazino[1,2-<em>a</em>]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.
chembl: MIANSERIN is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Mianserin, sold as Tolvon and other brand names, is an atypical antidepressant used primarily for treating depression in Europe and other countries. It is a tetracyclic antidepressant (TeCA) and is closely related to mirtazapine in terms of chemical structure, actions, and effects, although mianserin has greater noradrenergic activity and less 5-HT3 receptor antagonism.