Compound: DESONIDE
SMILES: O=C1C=C2[C@]([C@H]3[C@@H](O)C[C@@]4([C@@]5(OC(C)(C)O[C@@H]5C[C@H]4[C@@H]3CC2)C(=O)CO)C)(C)C=C1
InChIKey: WBGKWQHBNHJJPZ-LECWWXJVSA-N
Synonyms: DESONIDE, 638-94-8, Prednacinolone, DesOwen, Desonida, Desonate, Desonidum, Verdeso, Desocort, D-2083, desfluorotriamcinolone acetonide, DTXSID7046756, 16alpha-hydroxyprednisole-16,17-acetonide, D2083, 16alpha,17alpha-isopropylidenedioxyprednisolone, 16alpha-hydroxyprednisolone-16alpha,17-acetonide, J280872D1O, NSC-759226, DTXCID5026756, CHEBI:204734, 11beta,21-dihydroxy-16alpha,17-isopropylidenedioxypregna-1,4-diene-3,20-dione, 11beta,21-dihydroxy-16alpha,17alpha-isopropylidenedioxypregna-1,4-diene-3,20-dione, 11beta,21-dihydroxy-16alpha,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione, Pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-, (11beta,16alpha)-, Locatop, (1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosa-14,17-dien-16-one, Lokara, Tridesilon Cream, 11beta,21-dihydroxy-16alpha,17-((1-methylethylidene)bis(oxy))pregna-1,4-diene-3,20-dione, (1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo(10.8.0.0^(2,9).0^(4,8).0^(13,18))icosa-14,17-dien-16-one, desonide 0.05%, RefChem:54951, Desonide Ointment, 0.05%, D07AB08, S01BA11, 211-351-6, Locapred, Topifug, Tridesilon, Apolar, Steroderm, MFCD00866151, Sterax, Tridesonit, Desilux, 11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone, (1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one, Hamiltoderm, Flusemidon, Reticus, Zotinar, D 2083, Desonidum [INN-Latin], Desonida [INN-Spanish], Desonide [USAN:INN:BAN], CAS-638-94-8, Desowen (TN), Verdeso (TN), 16-alpha-Hydroxyprednisole-16,17-acetonide, UNII-J280872D1O, NCGC00167983-01, NCGC00274065-01, 16alpha,17-[1-Methylethylidenebis(oxy)]-11beta,21-dihydroxypregna-1,4-diene-3,20-dione (Desonide), Budesonide Imp. F (EP); Desonide; 16alpha,17-[1-Methylethylidenebis(oxy)]-11beta,21-dihydroxypregna-1,4-diene-3,20-dione; Budesonide Impurity F, EINECS 211-351-6, Desonide (Standard), Desonide (USP/INN), DESONIDE [USAN], DESONIDE [INN], DESONIDE [MI], DESONIDE [VANDF], DESONIDE [MART.], DESONIDE [USP-RS], DESONIDE [WHO-DD], SCHEMBL3631, DESONIDE [ORANGE BOOK], GTPL7066, orb1309538, orb3025703, DESONIDE [USP IMPURITY], CHEMBL1201109, DESONIDE [USP MONOGRAPH], HY-B0248R, 16a-Hydroxyprednisolone acetonide, HMS3715P20, Budesonide EP Impurity F(Desonide), HY-B0248, PREGNA-1,4-DIENE-3,20-DIONE, 11,21-DIHYDROXY-16,17-((1-METHYLETHYLIDENE)BIS(OXY))-, (11.BETA.,16.ALPHA.)-, TRIDESILON COMPONENT DESONIDE, Tox21_112603, 16alpha-Hydroxyprednisolone Acetonide, EBC-11100, MSK011038, s1701, AKOS037643323, Tox21_112603_1, CCG-221279, DB01260, MSK011038-100A, NSC 759226, (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, AS-13892, SY108234, BUDESONIDE IMPURITY F [EP IMPURITY], D5578, Desonide Solution in Acetonitrile, 100ug/mL, NS00010533, D03696, Desonide; Budesonide EP Impurity F (Desonide), F20496, AB01274712-01, AB01274712_02, EN300-7361932, F787579, Prednisolone-16,17-acetonide, 16-alpha-hydroxy-, Q904011, BRD-K21528677-001-02-8, BRD-K21528677-001-03-6, 11beta,21-Dihydroxy-16alpha,17alpha-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione, Dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione, (11b,16a)-11,21-Dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione, (11beta,16alpha)-11,21-Dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna -1,4-diene-3,20-dione, (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-Hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H,8H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, (6aR,6bS,7S,8aS,8bS,11aR,12aS,12bS)-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetramethyl-6a,6b,7,8,8a,8b,11a,12,12a,12b-decahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4(2H)-one, (6aR,6bS,7S,8aS,8bS,11aS,12aS,12bS)-7-Hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetramethyl-6a,6b,7,8,8a,8b,11a,12,12a,12b-decahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4(2H)-one, 16|A-Hydroxyprednisolone Acetonide; Locapred; Topifug; Tridesilon; (11|A,16|A)-11,21-Dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna -1,4-diene-3,20-dione
Theoretical properties:
molecular_formula: C24H32O6
molecular_weight: 416.5 g/mol
exact_mass: 416.21988874 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 2
hydrogen_bond_acceptor_count: 6
rotatable_bond_count: 2
heavy_atom_count: 30
topological_polar_surface_area: 93.1 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
melting_point: 257-260
solubility: Practically insoluble
Descriptions:
pubchem: Desonide is triamcinolone acetonide with hydrogen instead of the fluorine substituent at position 9. A corticosteroid anti-inflammatory, it is used topically as a cream, ointment or lotion for the treatment of various skin disorders. It has a role as an anti-inflammatory drug. It is a primary alpha-hydroxy ketone, a 21-hydroxy steroid, an 11beta-hydroxy steroid, a 20-oxo steroid, a corticosteroid, a cyclic ketal and a 3-oxo-Delta(1),Delta(4)-steroid.
chebi: Triamcinolone acetonide with hydrogen instead of the fluorine substituent at position 9. A corticosteroid anti-inflammatory, it is used topically as a cream, ointment or lotion for the treatment of various skin disorders.
chembl: DESONIDE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Desonide (INN) is a low-potency topical corticosteroid anti-inflammatory that has been available since the 1970s.  It is primarily used to treat atopic dermatitis (eczema), seborrheic dermatitis, contact dermatitis and psoriasis in both adults and children. It has a fairly good safety profile and is available as a cream, ointment, lotion, and as a foam under the tradename Verdeso Foam. Other trade names for creams, lotions, and ointments include Tridesilon, DesOwen, Desonate. It is a group VI corticosteroid under US classification, the second least potent group.