Compound: N-acetylserotonin
SMILES: O=C(NCCc1c2c(ccc(c2)O)[nH]c1)C
InChIKey: MVAWJSIDNICKHF-UHFFFAOYSA-N
Synonyms: N-acetylserotonin, 1210-83-9, N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]acetamide, O-Demethylmelatonin, Normelatonin, N-(2-(5-Hydroxy-1H-indol-3-yl)ethyl)acetamide, P4TO3C82WV, DTXSID00153106, CHEBI:17697, N-acetylhydroxytryptamine, RefChem:828919, DTXCID3075597, 214-916-5, N-Acetyl-5-hydroxytryptamine, acetylserotonin, N-ACETYL SEROTONIN, 5-Hydroxy-N-acetyltryptamine, 5-Hydroxymelatonin, Acetyl-5-hydroxy-tryptamine, MFCD00005656, Acetamide, N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-, CHEMBL33103, Acetamide, N-[2-(5-hydroxyindol-3-yl)ethyl]-, N-Acetylserotonin; Normelatonin; O-Demethylmelatonin, UNII-P4TO3C82WV, 3-(2-Acetamidoethyl)-5-hydroxyindole, ACETAMIDE, N-(2-(5-HYDROXYINDOL-3-YL)ETHYL)-, ACETAMIDE, N-(2-(5-HYDROXY-1H-INDOL-3-YL)ETHYL)-, Desmethylmelatonin, N-acetyl-serotonin, Serotonin,N-acetyl, N-acetyl serotonine, EINECS 214-916-5, Serotonin, N-acetyl-, Spectrum_000369, Spectrum3_001871, Spectrum4_001268, Spectrum5_000975, Lopac-A-1824, Lopac0_000044, BSPBio_003342, KBioGR_001856, KBioSS_000849, N-Acetyltryptamine,5-Hydroxy, MLS000859911, DivK1c_000668, SCHEMBL422165, SPECTRUM1500700, GTPL5451, N-Acetylserotonin; Normelatonin, orb1308869, orb3141311, SCHEMBL29375184, BDBM29612, HMS502B10, KBio1_000668, KBio2_000849, KBio2_003417, KBio2_005985, KBio3_002844, MSK2365, Tryptamine, N-acetyl-5-hydroxy-, NINDS_000668, HMS2235E22, HMS3260I09, HMS3372M05, N-Acetyl-5-hydroxytryptamine, 99%, Tox21_500044, EBC-47422, PDSP1_001650, PDSP1_001789, PDSP1_001790, PDSP1_001827, PDSP2_001634, PDSP2_001772, PDSP2_001773, PDSP2_001810, s2985, AKOS004120085, CCG-204140, DB04275, FA17088, HY-107854R, LP00044, SDCCGSBI-0050033.P003, IDI1_000668, N-Acetyl-5-hydroxytryptamine (Standard), NCGC00015039-01, NCGC00015039-02, NCGC00015039-03, NCGC00015039-04, NCGC00015039-05, NCGC00015039-06, NCGC00015039-07, NCGC00015039-08, NCGC00015039-09, NCGC00093558-01, NCGC00093558-02, NCGC00093558-03, NCGC00093558-04, NCGC00093558-05, NCGC00260729-01, AS-59415, SMR000326772, ST092857, SY051627, DB-007732, HY-107854, A1277, CS-0030736, EU-0100044, N-[2-(5-hydroxyindol-3-yl)ethyl]acetamide, N-Acetyl Serotonin; Melatonin EP Impurity B, NS00014788, A 1824, C00978, T70144, EN300-1699365, F510092, L000433, N-(2-(5-hydroxy-1H-indol-3-yl)ethyl) acetamide, N-Acetylserotonin;Normelatonin;O-Demethylmelatonin, SR-01000075660, N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]acetamide #, N-ACETYL-2-(5-HYDROXYINDOL-3-YL)ETHYLAMINE, Q4847704, SR-01000075660-1, BRD-K26140483-001-01-3, N-Acetyl-5-hydroxytryptamine, >=99% (TLC), powder, Q27216205, 7D6F82BE-C205-424F-9F26-65CE227610C0, 2,2,2-trideuterio-N-[1,1,2,2-tetradeuterio-2-(5-hydroxy-1H-indol-3-yl)ethyl]acetamide
Theoretical properties:
molecular_formula: C12H14N2O2
molecular_weight: 218.25 g/mol
exact_mass: 218.105527694 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 3
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 3
heavy_atom_count: 16
topological_polar_surface_area: 65.1 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
solubility: >32.7 [ug/mL] (The mean of the results at pH 7.4)
Descriptions:
pubchem: N-acetylserotonin is an N-acylserotonin resulting from the formal condensation of the primary amino group of serotonin with the carboxy group of acetic acid. It has a role as a tropomyosin-related kinase B receptor agonist, an antioxidant, a mouse metabolite and a human metabolite. It is a N-acylserotonin, a member of acetamides and a member of phenols.
chebi: An <em>N</em>-acylserotonin resulting from the formal condensation of the primary amino group of serotonin with the carboxy group of acetic acid.
chembl: ACETYLSEROTONIN is a small molecule listed in the ChEMBL database but has not progressed to an approved clinical phase.
wikipedia: N-Acetylserotonin (NAS), also known as normelatonin, is a naturally occurring chemical intermediate in the endogenous production of melatonin from serotonin. It also has biological activity in its own right, including acting as a melatonin receptor agonist, an agonist of the TrkB, and having antioxidant effects.