Compound: N-Methyl-N-nitrosourea
SMILES: O=NN(C(=O)N)C
InChIKey: ZRKWMRDKSOPRRS-UHFFFAOYSA-N
Synonyms: N-Methyl-N-nitrosourea, N-NITROSO-N-METHYLUREA, 684-93-5, Methylnitrosourea, Urea, N-methyl-N-nitroso-, 1-Nitroso-1-methylurea, Methylnitrosouree, N-Nitroso-N-methylcarbamide, Urea, 1-methyl-1-nitroso-, Methylnitroso-harnstoff, NSC 23909, SRI 859, N-Methyl-N-nitroso-harnstoff, N-Nitroso-N-methyl-harnstoff, SKI 24464, Carbamide, N-methyl-N-nitroso-, 1-Methyl-1-nitrosomocovina, W8KW4E3XSU, Methylnitrosoharnstoff, DTXSID4021006, DTXCID501006, CHEBI:50102, NSC23909, N Methyl N nitrosourea, RefChem:830834, 211-678-4, 1-Methyl-1-nitrosourea, NSC-23909, N-methylnitrosourea, RCRA waste number U177, MNU, NMH, NMU, N-methyl-N-nitrosurea, NMU;MNU;NMH, n-methyl-n-nitroso urea, MFCD00014794, 1-(Aminocarbonyl)-1-methyl-2-oxohydrazine, n-nitroso-n-methylurea (stabilized with 10% acetic acid), 28606-00-0, N-Nitroso-N-methyl urea, NMH [German], Urea, methylnitroso-, Methylnitrosouree [French], CCRIS 404, Methylnitroso-harnstoff [German], HSDB 5112, N-Methyl-N-nitroso Urea (Wetted with water >20%), 1-methyl-1-nitroso-urea, 1-Methyl-1-nitrosomocovina [Czech], EINECS 211-678-4, UNII-W8KW4E3XSU, RCRA waste no. U177, N-Methyl-N-nitroso-harnstoff [German], N-Nitroso-N-methyl-harnstoff [German], O-Nitroso-N-methyl-harnstoff [German], O-Nitroso-N-methyl-harnstoff, AI3-50583, (Contains Water), N-methyl-nitrosourea, N-methyl,N-nitrosourea, N-methyl-N-nitrosouree, N-nitroso-N-methyluree, WLN: ZVN1&NO, N-methyl-N-nitrosocarbamide, N-Methyl-N-nitrosoharnstoff, N-Nitroso-N-methylharnstoff, SCHEMBL38377, SCHEMBL250406, CHEMBL288958, orb1303094, MNU; NMH; Methyl-1-nitrosourea, AAA68493, Tox21_302850, EBC-04367, N-Nitroso-N-methylurea, ISOPAC(R), N-Nitroso-N-methylurea, Bulk package, AKOS006228360, N-METHYL-N-NITROSOUREA [IARC], N-NITROSO-N-METHYLUREA [HSDB], NCGC00256586-01, AS-31175, CAS-684-93-5, HY-34758, SY059503, DB-014949, CS-0022387, NS00022687, 1-(Aminocarbonyl)-1-methyl-2-oxohydrazine #, EN300-19856, F386800, Q3023727, Z104475776, N-Nitroso-N-methylurea (stabilised with 10% acetic acid)
Theoretical properties:
molecular_formula: C2H5N3O2
molecular_weight: 103.08 g/mol
exact_mass: 103.038176411 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 3
rotatable_bond_count: 0
heavy_atom_count: 7
topological_polar_surface_area: 75.8 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
physical_state: Colorless or yellow plates from ethanol
color: Colorless or yellow plates from ethanol
melting_point: 255 °F (decomposes) (NTP, 1992)
density: less than 1.0 (NTP, 1992)
solubility: less than 1 mg/mL at 64 °F (NTP, 1992)
vapor_pressure: Non-volatile (NTP, 1992)
Descriptions:
pubchem: N-Nitroso-N-methylurea can cause cancer according to an independent committee of scientific and health experts.
chebi: A member of the class of <em>N</em>-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups.
chembl: N-METHYL-N-NITROSUREA is a small molecule listed in the ChEMBL database but has not progressed to an approved clinical phase.
wikipedia: Arabinopyranosyl-N-methyl-N-nitrosourea, also known as Aranose (Араноза) is a cytostatic anticancer chemotherapeutic drug of an alkylating type. Chemically it is a nitrosourea derivative. It was developed in the Soviet Union in the 1970s. It was claimed by its developers that its advantages over other nitrosoureas are a relatively low hematological toxicity (compared to other nitrosoureas available at that time) and a wider therapeutic index, which allows for its outpatient administration.