Compound: Ohmefentanyl
SMILES: O=C(N(c1ccccc1)C2C(CN(CC(O)c3ccccc3)CC2)C)CC
InChIKey: FRPRNNRJTCONEC-UHFFFAOYSA-N
Synonyms: Ohmefentanyl, BETA-HYDROXY-3-METHYLFENTANYL, 78995-14-9, F 7302, N-[1-(2-hydroxy-2-phenylethyl)-3-methylpiperidin-4-yl]-N-phenylpropanamide, F-7302, Y8263089ZX, IDS-NB-010, DTXSID50868495, IDS-NB-010(SECT.3), RTI-4614-4, N-(1-(2-hydroxy-2-phenylethyl)-3-methylpiperidin-4-yl)-N-phenylpropanamide, RefChem:167999, DTXCID90816596, RTI-46144, RTI 6414-4, RTI-6414-4, N-(1-(2-hydroxy-2-phenylethyl)-3-methyl-4-piperidyl)-N-phenylpropanamide, N-(1-(beta-hydroxy beta-phenethyl)-3-methyl-4-piperidyl)-N-phenylpropionamide, CHEMBL333410, OMF, N-[1-(2-hydroxy-2-phenylethyl)-3-methyl-4-piperidinyl]-N-phenylpropanamide, N-[1-(beta-Hydroxyphenethyl)-3-methyl-4-piperidyl]propionanilide, Beta-Hydroxy-3-methylfentanyl (100ug/ml in Methanol), Beta-Hydroxy-3-methylfentanyl (1mg/ml in Acetonitrile), DEA No. 9831, UNII-Y8263089ZX, Propanamide, N-[1-(2-hydroxy-2-phenylethyl)-3-methyl-4-piperidinyl]-N-phenyl-; F 7302; Ohmefentanyl; beta-Hydroxy-3-methylfentanyl, N-(1-(2-Hydroxy-1-methyl-2-phenylethyl)-3-methyl-4-piperidinyl)-N-phenylpropanamide, RTI-4614-4 free base, SCHEMBL722133, ACSCN-9831, GTPL13538, CHEBI:194294, BDBM50033531, AKOS030242800, N-(1-(2-Hydroxy-2-phenethyl)-3-methyl-4-piperidinyl)-N-phenylpropanamide, N-[1-(2-hydroxy-2-phenyl-ethyl)-3-methyl-4-piperidyl]-N-phenyl-propanamide, DB01570, Propanamide, N-(1-(2-hydroxy-1-methyl-2-phenylethyl)-3-methyl-4-piperidinyl)-N-phenyl-, F7302, NS00015491, C22750, L000454, Beta-Hydroxy-3-methylfentanyl (1 mg/ml in Acetonitrile), beta-Hydroxy-3-methylfentanyl (100 ug/ml in Methanol), N-(1-(.BETA.-HYDROXYPHENETHYL)-3-METHYL-4-PIPERIDYL)PROPIONANILIDE, N-(1-(2-HYDROXY-2- PHENETHYL)-3-METHYL-4-PIPERIDINYL)-N-PHENYLPROPANAMIDE, N-[1-(2-Hydroxy-2-phenyl-ethyl)-3-methyl-piperidin-4-yl]-N-phenyl-propionamide, Propanamide, N-[1-(2-hydroxy-2-phenylethyl)-3-methyl-4-piperidinyl]-N-phenyl-
Theoretical properties:
molecular_formula: C23H30N2O2
molecular_weight: 366.5 g/mol
exact_mass: 366.230728204 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 3
rotatable_bond_count: 6
heavy_atom_count: 27
topological_polar_surface_area: 43.8 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
{"pubchem": "Ohmefentanyl is a monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of 2-(4-anilino-3-methylpiperidin-1-yl)-1-phenylethanol with propanoic acid. It is a synthetic analogue of fentanyl. It has a role as an opioid analgesic and a mu-opioid receptor agonist. It is an anilide, a member of benzyl alcohols, a member of piperidines, a monocarboxylic acid amide and a tertiary amino compound.", "chebi": "A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of 2-(4-anilino-3-methylpiperidin-1-yl)-1-phenylethanol with propanoic acid. It is a synthetic analogue of fentanyl.", "chembl": "Unnamed Compound is a small molecule listed in the ChEMBL database but has not progressed to an approved clinical phase.", "wikipedia": "Ohmefentanyl (also known as \u03b2-hydroxy-3-methylfentanyl, OMF and  RTI-4614-4) is an extremely potent opioid analgesic drug which selectively binds to the \u03bc-opioid receptor.\nThere are eight possible stereoisomers of ohmefentanyl.  These stereoisomers are among the most potent \u03bc-opioid receptor agonists known, comparable to super-potent opioids such as carfentanil and etorphine which are only legally used for tranquilizing large animals such as elephants in veterinary medicine.  In mouse studies, the most active stereoisomer, 3R,4S,\u03b2S-ohmefentanyl, was 28 times more powerful as a painkiller than fentanyl, the chemical from which it is derived, and 6300 times more powerful than morphine. Ohmefentanyl has three stereogenic centers and eight stereoisomers, which are named F9201\u2013F9208. Researchers are studying the different pharmaceutical properties of these isomers.\nThe 4\u2033-fluoro analogue (i.e., substituted on the phenethyl ring) of the 3R,4S,\u03b2S isomer of ohmefentanyl is one of the most potent opioid agonists yet discovered, possessing an analgesic potency approximately 18,000 times that of morphine. Other analogues with potency higher than that of ohmefentanyl itself include the 2\u2032-fluoro derivative (i.e., substituted on the aniline phenyl ring), and derivatives where the N-propionyl group was replaced by N-methoxyacetyl or 2-furamide groups, or a carboethoxy group is added to the 4-position of the piperidine ring. The latter is listed as being up to 30,000 times more potent than morphine.\nSide effects of fentanyl analogues are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Illicitly used fentanyl analogues have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear."}