Compound: dipyridamole
SMILES: OCCN(c1nc(N2CCCCC2)c3nc(N(CCO)CCO)nc(c3n1)N4CCCCC4)CCO
InChIKey: IZEKFCXSFNUWAM-UHFFFAOYSA-N
Synonyms: dipyridamole, 58-32-2, Persantin, Dipyridamine, Persantine, Curantyl, Dipyudamine, Dipiridamol, Cleridium 150, Dypyridamol, Iv Persantine, Dipyridamolum, NSC-515776, DTXSID6040668, 64ALC7F90C, B01AC07, NSC515776, 2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin-1-yl)pyrimido[5,4-d][1,3]diazin-2-yl}(2-hydroxyethyl)amino)ethan-1-ol, 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol, CHEBI:4653, Dipyramidole, DTXCID4020668, Novo Dipiradol, Apo Dipyridamole, 2,2',2'',2'''-{[4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo}tetraethanol, dipiridamolo, Dipridamole, Pyridantin, Modaplate, Vasyrol, Attia, Persantin ret, Ofcram pr, Cerebrovase 25, Cerebrovase 100, 2,2',2'',2'''-((4,8-Di(piperidin-1-yl)pyrimido(5,4-d)pyrimidine-2,6-diyl)dinitrilo)tetraethanol, 2-((2-(bis(2-hydroxyethyl)amino)-4,8-di(piperidin-1-yl)pyrimido(5,4-d)pyrimidin-6-yl)-(2-hydroxyethyl)amino)ethanol, 2-((6-(bis(2-hydroxyethyl)amino)-4,8-bis(piperidin-1-yl)pyrimido(5,4-d)(1,3)diazin-2-yl)(2-hydroxyethyl)amino)ethan-1-ol, RefChem:55053, 2,2',2'',2''''-((4,8-Dipiperidinopyrimido-(5,4-d)pyrimidine-2,6-diyl)dinitrilo)tetraethanol, 200-374-7, Dipyridamol, Stenocardil, Stimolcardio, Cardioflux, Kurantil, Anginal, Apricor, Coribon, Corosan, Coroxin, Dipyridan, Peridamol, Permiltin, Agilease, Piroan, Stenocardiol, Chilcolan, Gulliostin, Justpertin, Coronarine, Prandiol, Natyl, Prandiol 75, Usaf Ge-12, 2,2',2'',2'''-((4,8-Di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine-2,6-diyl)bis(azanetriyl))tetraethanol, RA-8, RA 8, C24H40N8O4, MFCD00010555, NSC 515776, MLS000028420, Cleridium, Dipyridamole (Persantine), Dypyridamole, CHEMBL932, 2,6-Bis(diethanolamino)-4,8-dipiperidinopyrimido(5,4-d)pyrimidine, SMR000058382, 2,2',2'',2'''-((4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine-2,6-diyl)bis(azanetriyl))tetrakis(ethan-1-ol), Cardoxil, Pyrimido(5,4-d)pyrimidine, 2,6-bis(bis(2-hydroxyethyl)amino)-4,8-dipiperidino-, Ethanol, 2,2',2'',2'''-[(4,8-di-1-piperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakis-, Ethanol,2,2',2'',2'''-[(4,8-di-1-piperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakis-, CAS-58-32-2, NCGC00015385-12, Coridil, Protangix, 2,6-Bis(diethanolamine)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine, 2,6-Bis(diethanolamino)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine, 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-bis(1-piperidyl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol, Ethanol, 2,2',2'',2'''-((4,8-di-1-piperidinylpyrimido(5,4-d)pyrimidine-2,6-diyl)dinitrilo)tetrakis-, Dipiridamol [INN-Spanish], Dipyridamolum [INN-Latin], Permole, Persantine (TN), (3E)-3-[[(1S,4aS,8aS)-Decahydro-5,5,8a-trimethyl-2-methylene-1-naphthalenyl]methylene]dihydro-5-methoxy-2(3H)3-[(1E)-2-[(1S,4aS,8aS)-Decahydro-5,5,8a-trimethyl-2-methylene-1-naphthalenyl]ethenyl]furan; (+)-Coronarin E-furanone; Coronarin D methyl ethe, 2,2',2'',2'''-((4,8-Di(piperidin-1-yl)pyrimido[5,4-d]-pyrimidine-2,6-diyl)bis(azanetriyl))tetraethanol, 2,2',2'',2'''-[(4,8-Di-1-piperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakis-ethanol, SR-01000003065, EINECS 200-374-7, BRN 0068373, UNII-64ALC7F90C, Curanty, Persantin;, Dipyridamole CRS, Dipyridamole; 2,2',2'',2'''-[[4,8-Di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo]tetraethanol, H9F, Prestwick_145, Dipyridamole [USAN:USP:INN:BAN:JAN], Spectrum_001004, Tocris-0691, Dipyridamole (Standard), Opera_ID_494, Prestwick0_000142, Prestwick1_000142, Prestwick2_000142, Prestwick3_000142, Spectrum2_000972, Spectrum3_000402, Spectrum4_000522, Spectrum5_000839, DIPYRIDAMOLE [MI], Lopac-D-9766, DIPYRIDAMOLE [INN], DIPYRIDAMOLE [JAN], UPCMLD-DP072, D 9766, DIPYRIDAMOLE [USAN], cid_3108, 2,2',2'',2'''-((4,8-Dipiperidinopyrimido(5,4-d)pyrimidine-2,6-diyl)dinitrilo)tetraethanol, DIPYRIDAMOLE [VANDF], Lopac0_000464, SCHEMBL16119, BSPBio_000244, BSPBio_001554, BSPBio_001924, DIPYRIDAMOLE [MART.], KBioGR_001123, KBioSS_001484, 4-26-00-03840 (Beilstein Handbook Reference), MLS001076306, MLS001333724, MLS002548866, DIPYRIDAMOLE [USP-RS], DIPYRIDAMOLE [WHO-DD], Dipyridamole Impurity Standard, DivK1c_000696, SPECTRUM1500259, SPBio_001003, SPBio_002183, BPBio1_000270, GTPL4807, orb1307994, SCHEMBL29381078, Thymidine,6-dihydro-6-methoxy-, UPCMLD-DP072:001, BDBM23620, Dipyridamole (JP18/USP/INN), HMS502C18, HY-B0312R, IZEKFCXSFNUWAM-UHFFFAOYSA-, KBio1_000696, KBio2_001484, KBio2_004052, KBio2_006620, KBio3_001144, NINDS_000696, DIPYRIDAMOLE [ORANGE BOOK], GLXC-07962, HMS1568M06, HMS1791N16, HMS1920I10, HMS1989N16, HMS2089N15, HMS2091O18, HMS2095M06, HMS2232E19, HMS3259C03, HMS3261M10, HMS3266J17, HMS3371J03, HMS3402N16, HMS3411B03, HMS3655I20, HMS3675B03, HMS3712M06, HMS3742O03, HMS3867F13, HMS5080C21, Pharmakon1600-01500259, DIPYRIDAMOLE [EP MONOGRAPH], HY-B0312, MSK14886, PXB98352, DIPYRIDAMOLE [USP MONOGRAPH], Tox21_110133, Tox21_500464, BBL027781, CCG-40190, EBC-00632, NSC756743, s1895, STL377790, AGGRENOX COMPONENT DIPYRIDAMOLE, AKOS000509426, Tox21_110133_1, DB00975, Dipyridamole, >=98% (TLC), powder, FD22534, HS-0041, LP00464, NC00448, NSC-619103, NSC-756743, SDCCGSBI-0050449.P005, Dipyridamole for peak identification CRS, IDI1_000696, SMP2_000208, NCGC00015385-01, NCGC00015385-02, NCGC00015385-03, NCGC00015385-04, NCGC00015385-05, NCGC00015385-06, NCGC00015385-07, NCGC00015385-08, NCGC00015385-09, NCGC00015385-10, NCGC00015385-11, NCGC00015385-13, NCGC00015385-14, NCGC00015385-15, NCGC00015385-16, NCGC00015385-17, NCGC00015385-18, NCGC00015385-29, NCGC00023914-02, NCGC00023914-04, NCGC00023914-05, NCGC00023914-06, NCGC00023914-07, NCGC00023914-08, NCGC00023914-09, NCGC00023914-10, NCGC00023914-11, NCGC00261149-01, 2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin-1-yl)-[1,3]diazino[5,4-d]pyrimidin-2-yl}(2-hydroxyethyl)amino)ethan-1-ol, AC-18100, AC-30804, Ethanol, 2,2',2'',2'''-((4,8-dipiperidinopyrimido(5,4-d)pyrimidine-2,6-diyl)dinitrilo)tetra-, NCI60_005689, ST078856, SBI-0050449.P004, 2,8-dipiperidinopyrimido[5,4-d]pyrimidine, AB00051974, EU-0100464, NS00010369, SW196456-3, EN300-70723, BIM-0050449.0001, D00302, O10551, AB00051974-18, AB00051974-19, AB00051974_20, AB00051974_21, F079856, Q419374, SR-01000003065-2, SR-01000003065-4, SR-01000003065-5, SR-01000003065-7, BRD-K86301799-001-04-1, BRD-K86301799-001-19-9, BRD-K86301799-001-24-9, BRD-K86301799-001-34-8, BRD-K86301799-001-35-5, BRD-K86301799-001-36-3, BRD-K86301799-001-37-1, Z1137167676, Dipyridamole, British Pharmacopoeia (BP) Reference Standard, Dipyridamole, European Pharmacopoeia (EP) Reference Standard, Dipyridamole, United States Pharmacopeia (USP) Reference Standard, Pyrimido(5, 2,6-bis[bis(2-hydroxyethyl)amino]-4,8-diperidino-, 2,6-Bis(diethanolamino)-4,8-dipipe  ridinopyrimido[5,4-d]pyrimidine, 2,2'',2'''-[4,8-Dipiperidinopyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilotetraethanol, 2,2',2'',2'''-(4,8-Dipiperidinopyrimido(5,4-d)pyrimidine-2,6-diyl)dinitrilotetraethanol, 2-[[2-(bis(2-hydroxyethyl)amino)-4,8-di(piperidin-1-yl)pyrimido[6,5-e]pyrimidin-, Dipyridamole for peak identification, European Pharmacopoeia (EP) Reference Standard, Ethanol,2',2'',2'''-(4,8-dipiperidinopyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetra-, WLN: T66 BN DN GN INJ CCN HCN E- AT6NTJ B2Q F2Q& J- AT6NTJ B2Q F2Q, 2,2',2'',2'''-[(4,8-dipiperidin-1-ylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetraethanol, 2,2',2'',2'''-[(4,8-Dipiperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetraethanol, 2,2',2'',2'''-[(4,8-Dipiperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakisethanol, 2,2',2'',2'''-{[4,8-Di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo}tetra(ethan-1-ol), 2-({6-[bis(2-hydroxyethyl)amino]-4,8-dipiperidylpyrimidino[5,4-d]pyrimidin-2-y l}(2-hydroxyethyl)amino)ethan-1-ol, Ethanol, 2,2',2'',2'''-(4,8-dipiperidinopyrimido(5,4-d)pyrimidine-2,6-diyldinitrilo)tetra-, Ethanol, 2,2',2',2'''-((4,8-di-1-iperidinylpyrimido(5,4-d)pyrimidine-2,6-diyl)dinitrilo)tetrakis-, Ethanol,2',2'',2'''-[(4,8-di-1-piperidinylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetrakis-, Ethanol,2',2'',2'''-[(4,8-dipiperidinopyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetra-, InChI=1/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2
Theoretical properties:
molecular_formula: C24H40N8O4
molecular_weight: 504.6 g/mol
exact_mass: 504.31725179 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 4
hydrogen_bond_acceptor_count: 12
rotatable_bond_count: 12
heavy_atom_count: 36
topological_polar_surface_area: 145 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
solubility: Slightly
Descriptions:
pubchem: Dipyridamole is a pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots. It has a role as a vasodilator agent, a platelet aggregation inhibitor, an adenosine phosphodiesterase inhibitor and an EC 3.5.4.4 (adenosine deaminase) inhibitor. It is a member of piperidines, a tetrol, a pyrimidopyrimidine and a tertiary amino compound.
chebi: A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-<em>d</em>]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.
chembl: DIPYRIDAMOLE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Dipyridamole, sold under the brand name Persantine among others, is an antiplatelet drug of the nucleoside transport inhibitor and PDE3 inhibitor class that inhibits blood clot formation when given chronically and causes blood vessel dilation when given at high doses over a short time.