Compound: Arformoterol
SMILES: O=CNc1c(O)ccc(c1)[C@@H](O)CN[C@@H](Cc2ccc(OC)cc2)C
InChIKey: BPZSYCZIITTYBL-YJYMSZOUSA-N
Synonyms: Arformoterol, (R,R)-Formoterol, 67346-49-0, (-)-Formoterol, N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]phenyl]formamide, F91H02EBWT, N-{2-hydroxy-5-[(1R)-1-hydroxy-2-{[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino}ethyl]phenyl}formamide, CHEBI:408174, DTXSID40110071, Formamide, N-(2-hydroxy-5-((1R)-1-hydroxy-2-(((1R)-2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)phenyl)-, Formamide, N-(2-hydroxy-5-(1-hydroxy-2-((2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)phenyl)-, (R-(R*,R*))-, arformoterolum, Formoterol r,r-, Formamide, N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, N-(2-hydroxy-5-((1R)-1-hydroxy-2-(((2R)-1-(4-methoxyphenyl)propan-2-yl)amino)ethyl)phenyl)formamide, RefChem:5561, DTXCID203077, Arformoterol [INN], Atimos, Arformoterol (INN), CHEMBL1363, Formoterolum [INN-Latin], Innovair, Fluir, MFCD05662345, Racemic formoterol, FORMOTEROL [INN], UNII-5ZZ84GCW8B, UNII-F91H02EBWT, Formoterol [USAN:INN:BAN], HSDB 7287, H98, Formoterol r,r-form, FORMOTEROL [MI], FORMOTEROL [HSDB], FORMOTEROL [VANDF], (R,R)-Formoterol Impurity, SCHEMBL4247, ARFORMOTEROL [VANDF], FORMOTEROL [WHO-DD], ARFORMOTEROL [WHO-DD], GTPL7479, SCHEMBL29363091, SCHEMBL30154976, cid_9912089, HY-B0010A, (R,R)-Formoterol (Arformoterol), BPZSYCZIITTYBL-YJYMSZOUSA-N, FORMOTEROL R,R-FORM [MI], GLXC-23132, BDBM50151720, EBC-26672, AKOS015969668, CS-1413, DB01274, FF35161, N-(2-Hydroxy-5-((R)-1-hydroxy-2-(((R)-1-(4-methoxyphenyl)propan-2-yl)amino)ethyl)phenyl)formamide, N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methyl-ethyl]amino]ethyl]phenyl]formamide, N-{2-hydroxy-5-[(1R)-1-hydroxy-2-({(1R)-1-methyl-2-[4-(methyloxy)phenyl]ethyl}amino)ethyl]phenyl}formamide, NS00120489, D07463, D87655, EN300-174504, Q4789167, (-)-N-(2-HYDROXY-5-((1R)-1-HYDROXY-2-(((1R)-2-(4-METHOXYPHENYL)-1-METHYLETHYL)AMINO)ETHYL)PHENYL)FORMAMIDE HYDROGEN (2R,3R)-2,3-DIHYDROXYBUTANEDIOATE, FORMAMIDE, N-(2-HYDROXY-5-(1-HYDROXY-2-((2-(4-METHOXYPHENYL)-1-METHYLETHYL)AMINO)ETHYL)PHENYL)-, N-(2-hydroxy-5-((R)-1-hydroxy-2-((R)-1-(4-methoxyphenyl)propan-2-ylamino)ethyl)phenyl)formamide, N-(2-Hydroxy-5-{1-hydroxy-2-[2-(4-methoxy-phenyl)-1-methyl-ethylamino]-ethyl}-phenyl)-formamide, rel-n-[2-hydroxy-5-[(1r)-1-hydroxy-2-[[(1r)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide
Theoretical properties:
molecular_formula: C19H24N2O4
molecular_weight: 344.4 g/mol
exact_mass: 344.17360725 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 4
hydrogen_bond_acceptor_count: 5
rotatable_bond_count: 8
heavy_atom_count: 25
topological_polar_surface_area: 90.8 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
solubility: 4.16e-02 g/L
Descriptions:
pubchem: Arformoterol is an N-[2-hydroxy-5-(1-hydroxy-2-{[1-(4-methoxyphenyl)propan-2-yl]amino}ethyl)phenyl]formamide in which both of the stereocentres have R configuration. The active enantiomer of formoterol, it is administered by inhalation (generally as the tartrate salt) as a direct-acting sympathomimetic and bronchodilator for the treatment of chronic obstructive pulmonary disease (any progressive respiratory disease that makes it harder to breathe over time, such as chronic bronchitis and emphysema). It has a role as a beta-adrenergic agonist, a bronchodilator agent and an anti-asthmatic drug. It is a conjugate base of an arformoterol(1+). It is an enantiomer of a (S,S)-formoterol.
chebi: An <em>N</em>-[2-hydroxy-5-(1-hydroxy-2-{[1-(4-methoxyphenyl)propan-2-yl]amino}ethyl)phenyl]formamide in which both of the stereocentres have <i>R</i> configuration. The active enantiomer of formoterol, it is administered by inhalation (generally as the tartrate salt) as a direct-acting sympathomimetic and  bronchodilator for the treatment of chronic obstructive pulmonary disease (any progressive respiratory disease that makes it harder to breathe over time, such as chronic bronchitis and emphysema).
chembl: ARFORMOTEROL is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Arformoterol, sold under the brand name Brovana among others, is a medication used for the treatment of chronic obstructive pulmonary disease (COPD).
It is a long-acting β2 adrenoreceptor agonist (LABA) and it is the active (R,R)-(−)-enantiomer of formoterol. It was approved for medical use in the United States in October 2006. It is available as a generic medication.