Compound: manidipine
SMILES: O=[N+]([O-])c1cc(ccc1)C2C(=C(NC(=C2C(=O)OC)C)C)C(=O)OCCN3CCN(C(c4ccccc4)c5ccccc5)CC3
InChIKey: ANEBWFXPVPTEET-UHFFFAOYSA-N
Synonyms: manidipine, 89226-50-6, Franidipine, Artedil, Manidipine 6300, Manidipino, 5-O-[2-(4-benzhydrylpiperazin-1-yl)ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, 6O4754US88, DTXSID2043745, 2-(4-Diphenylmethyl-1-piperazinyl)ethyl methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate, 3-{2-[4-(diphenylmethyl)piperazin-1-yl]ethyl} 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, manidipinum, 3-(2-(4-(diphenylmethyl)piperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, 5-O-(2-(4-benzhydrylpiperazin-1-yl)ethyl) 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, manidipine, (+-)-, RefChem:809939, DTXCID0023745, C08CA11, 120092-68-4, 3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, Iperten, Manidipine [INN], MFCD00871291, C35H38N4O6, Manidipine (Manyper), CHEMBL312176, 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester, CV 4093, Manidipine (INN), 2-[4-(diphenylmethyl)piperazin-1-yl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O5-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] ester O3-methyl ester, SMR003500793, (+/-)-Manidipine, NCGC00167493-01, NCGC00167493-04, Manidipine 6300 [INN], UNII-6O4754US88, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-Pyridinedicarboxylic acid 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester (9CI); (+/-)-Manidipine; Franidipine; Manidipine; Manidipine 6300, 3,5-PYRIDINEDICARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-, 3-(2-(4-(DIPHENYLMETHYL)-1-PIPERAZINYL)ETHYL) 5-METHYL ESTER, Artedil (TN), MANIDIPINE [MI], Manidipine(CV-4093), MANIDIPINE [WHO-DD], SCHEMBL49368, MLS004774156, MLS006011791, orb1300643, SCHEMBL29801590, GTPL11739, ANEBWFXPVPTEET-UHFFFAOYSA-N, CHEBI:135849, BDBM642534, GLXC-07948, HMS2089K12, HMS3264H11, HMS3656C06, HMS3884D21, HMS5081O09, HY-B0419, SYB71854, BDBM50227969, EBC-11219, s2481, STK635322, AKOS003589070, AKOS016842350, CCG-213069, DB09238, DS-1275, US20230414632, Compound I-g, NCGC00167493-02, NCGC00167493-03, 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(4-(diphenylmethyl)-1-piperazinyl)ethyl methyl ester, O5-[2-(4-benzhydrylpiperazin-1-yl)ethyl] O3-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, SY112666, DB-041526, DB-239666, NS00001355, SW219347-1, D08155, SBI-0653413.0001, AB01274741-01, AB01274741-02, AB01274741-03, AB01274741_04, AB01274741_05, Q921133, SR-05000002134, SR-05000002134-1, BRD-A90695733-001-01-7, BRD-A90695733-001-06-6, BRD-A90695733-001-07-4, BRD-A90695733-001-08-2, BRD-A90695733-300-02-1, (5-(Methylsulfonyl)-2-((R)-1,1,1-trifluoropropan-2-yloxy)phenyl)((1R,5R)-1-(5-(trifluoromethyl)isoxazol-3-yl)-3-azabicyclo[3.1.0]hexan-3-yl)methanone, 2-(4-(DIPHENYLMETHYL)-1-PIPERAZINYL)ETHYL METHYL (+/-)-1,4-DIHYDRO-2,6-DIMETHYL-4-(M-NITROPHENYL)-3,5-PYRIDINECARBOXYLATE, 2-[4-(Diphenylmethyl)-1-Piperazinyl]Ethyl Methyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydro-3,5-Pyridinedicarboxylate, 3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, (+/-)-, 3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, (A+/-)-, 3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl)5-methyl2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Theoretical properties:
molecular_formula: C35H38N4O6
molecular_weight: 610.7 g/mol
exact_mass: 610.27913494 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 9
rotatable_bond_count: 11
heavy_atom_count: 45
topological_polar_surface_area: 117 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
solubility: <1mg/mL
Descriptions:
pubchem: Manidipine is a diarylmethane.
chembl: MANIDIPINE 6300 is a small molecule listed in the ChEMBL database and has reached clinical trial phase 3.0.
wikipedia: Manidipine is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive.
It was patented in 1982 and approved for medical use in 1990.