Compound: Dexrazoxane
SMILES: O=C1NC(=O)CN(C1)[C@H](CN2CC(=O)NC(C2)=O)C
InChIKey: BMKDZUISNHGIBY-ZETCQYMHSA-N
Synonyms: Dexrazoxane, 24584-09-6, ICRF-187, Dextrorazoxane, Dexrazoxano, Dexrazoxanum, ADR-529, Razoxane, d-, Razoxane, (s)-, (+)-(S)-4,4'-Propylenedi-2,6-piperazinedione, 4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione, ADR 529, ICRF 187, (+)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane, NSC-169780, NSC 169780, CHEBI:50223, 048L81261F, 2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-, (+)-, 4-[(2S)-1-(3,5-dioxopiperazin-1-yl)propan-2-yl]piperazine-2,6-dione, NSC169780, 4-((2S)-2-(3,5-dioxopiperazin-1-yl)propyl)piperazine-2,6-dione, ADR529, 4-((2S)-1-(3,5-dioxopiperazin-1-yl)propan-2-yl)piperazine-2,6-dione, 6-hydroxy-4-((2S)-2-(5-hydroxy-3-oxo-1,2,3,6-tetrahydropyrazin-1-yl)propyl)-2,3,4,5-tetrahydropyrazin-2-one, 6-hydroxy-4-[(2S)-2-(5-hydroxy-3-oxo-1,2,3,6-tetrahydropyrazin-1-yl)propyl]-2,3,4,5-tetrahydropyrazin-2-one, Razoxane (+)-, Soluble ICRF (L-, RefChem:56380, Hydrochloride, Dexrazoxane, ICRF187, V03AF02, Razoxane, (S)-Isomer, Hydrochloride, 2,6-Piperazinedione, 4,4'propylenedi-,(P)-, 2, 6-Piperazinedione, 4,4'-propylenedi-, (P)-, (+)-(S)-4,4'-(1-Methyl-1,2-ethanediyl)di(2,6-piperazinedione), 2,6-Piperazinedione, 4, 4'-(1-methyl-1,2-ethanediyl)bis-, (S)-, 2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-,(S)-, Zinecard, (S)-4,4'-(Propane-1,2-diyl)bis(piperazine-2,6-dione), Dexrazoxanum [INN-Latin], Dexrazoxano [INN-Spanish], 2,6-Piperazinedione, 4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis-, Dexrazone, Desrazoxane, MFCD00866449, DTXSID3040647, 4,4'-[(1S)-1-Methyl-1,2-ethanediyl]bis-2,6-piperazinedione, (+)-dexrazoxane, 2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-, (S)-, Razoxanum [INN-Latin], Razoxana [INN-Spanish], DTXCID1020647, CAS-24584-09-6, HSDB 7319, (+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane, 2,6-Piperazinedione, 4,4'-propylenedi-, (+)-, SR-01000883995, BRN 5759131, Soluble ICRF (L-isosomer), Dexrazoxane [USAN:INN:BAN], Dexrazoxane?, CCRIS 9394, UNII-048L81261F, NCGC00164737-01, Razoxane (+)-form, Dexrazoxane (Standard), DEXRAZOXANE [INN], DEXRAZOXANE [JAN], DEXRAZOXANE [HSDB], DEXRAZOXANE [USAN], DEXRAZOXANE [VANDF], (S)-4,4'-(Propane-1,2-diyl)-bis(piperazine-2,6-dione), CHEMBL1738, DEXRAZOXANE [MART.], SCHEMBL18400, DEXRAZOXANE [WHO-DD], MLS006010158, BIDD:GT0068, Dexrazoxane (JAN/USAN/INN), DEXRAZOXANE [EMA EPAR], (S)-(+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane, 4,4'-(2S)-propane-1,2-diyldipiperazine-2,6-dione, GTPL7330, orb1306016, Dexrazoxane - Bio-X trade mark, Dexrazoxane, >=95% (HPLC), HY-B0581R, WLZ4517, GLXC-07938, RAZOXANE (+)-FORM [MI], HY-B0581, Tox21_112256, 2, 4,4'-propylenedi-, (+)-, BDBM50586360, EBC-26383, s5651, AKOS015896392, Tox21_112256_1, (+)-1,5-dioxopiperazin-1-yl)propane, CCG-267131, DB00380, DS-1394, FD65001, NCGC00263544-01, NCGC00263544-02, BD164365, Dexrazoxane, analytical reference material, NCI60_001367, SMR002529680, (S)-(+)-1,5-dioxopiperazin-1-yl)propane, D4227, NS00073041, D03730, (S)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane, AB01273932-01, AB01273932-02, AB01273932_03, EN300-7356981, 2,4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis-, Q524995, 2,4,4'-(1-methyl-1,2-ethanediyl)bis-, (S)-, SR-01000883995-1, SR-01000883995-2, SR-01000883995-5, BRD-K07265709-003-01-5, BRD-K07265709-003-03-1, BRD-K07265709-003-04-9, BRD-K07265709-003-05-6, (S)-4,4-(Propane-1,2-diyl)bis(piperazine-2,6-dione), 4,4'-[(2S)-Propane-1,2-diyl]di(piperazine-2,6-dione)
Theoretical properties:
molecular_formula: C11H16N4O4
molecular_weight: 268.27 g/mol
exact_mass: 268.11715500 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 2
hydrogen_bond_acceptor_count: 6
rotatable_bond_count: 3
heavy_atom_count: 19
topological_polar_surface_area: 98.8 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
physical_state: Crystals from aqueous methanol/ether
color: Crystals from aqueous methanol/ether
melting_point: 191-197 °C
solubility: Sparingly soluble
vapor_pressure: 2.0X10-15 mm Hg at 25 °C /Estimated/
Descriptions:
pubchem: (+)-dexrazoxane is a razoxane. It has a role as a cardiovascular drug, an antineoplastic agent, an immunosuppressive agent and a chelator.
chembl: DEXRAZOXANE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Dexrazoxane hydrochloride, sold under the brand name Zinecard among others, is a cardioprotective agent. It was discovered in 1972. The IV administration of dexrazoxane is in acidic condition with HCl adjusting the pH.