Compound: diphenylpyraline
SMILES: O(C1CCN(C)CC1)C(c2ccccc2)c3ccccc3
InChIKey: OWQUZNMMYNAXSL-UHFFFAOYSA-N
Synonyms: diphenylpyraline, 147-20-6, Lyssipoll, Mepiben, Neargal, 4-(Diphenylmethoxy)-1-methylpiperidine, 4-(Benzhydryloxy)-1-methylpiperidine, Diphenylpyralamine, Allergen, Difenilpiralina, Diphenylpyralinum, AN 1041, 1-Methyl-4-piperidyl benzhydryl ether, 4-DIPHENYLMETHOXY-1-METHYLPIPERIDINE, 4-(benzhydryloxy)-N-methylpiperidine, 33361OE3AV, 1-methyl-4-hydroxypiperidine benzhydryl ether, DTXSID3022952, CHEBI:59788, RefChem:588945, DTXCID302952, CHEBI:50904, R06AA07, 205-686-7, Diphenylpyrilene, Belfene, Dayfen, Histyn, Diphenylpyraline (INN), PIPERIDINE, 4-(DIPHENYLMETHOXY)-1-METHYL-, CHEMBL1492, N-Methylpiperidyl-(4)-benzhydrylaether salzsauren salze, Hystryl, P 253, 4-benzhydryloxy-1-methyl-piperidine, DIPHENYLPYRALINE [INN], Diphenylpyraline [INN:BAN], Difenilpiralina [INN-Spanish], Diphenylpyralinum [INN-Latin], 4-benzhydryloxy-1-methylpiperidine, NSC61825, NCGC00016395-01, CAS-132-18-3, EINECS 205-686-7, BRN 0245467, UNII-33361OE3AV, N-Methylpiperidyl-(4)-benzhydrylaether salzsauren salze [German], Diafen (Salt/Mix), Spectrum_001002, 4-[(diphenylmethyl)oxy]-1-methylpiperidine, Prestwick0_000707, Prestwick1_000707, Prestwick2_000707, Prestwick3_000707, Spectrum2_000982, Spectrum3_000401, Spectrum4_000521, Spectrum5_000917, NCIOpen2_007716, Oprea1_289175, BSPBio_000893, BSPBio_001922, DIPHENYLPYRALINE [MI], KBioGR_001121, KBioSS_001482, 5-21-01-00053 (Beilstein Handbook Reference), DivK1c_000851, SCHEMBL119077, SPBio_001043, SPBio_002814, BPBio1_000983, GTPL7165, orb1710759, DIPHENYLPYRALINE [VANDF], KBio1_000851, KBio2_001482, KBio2_004050, KBio2_006618, KBio3_001142, DIPHENYLPYRALINE [WHO-DD], NINDS_000851, MSK11197, BDBM50241333, EBC-26434, MFCD00242657, STL599004, T0059L, N-Methyl-4-(Benzhydryloxy)piperidine, AKOS015889312, AC-9855, DB01146, IDI1_000851, NCGC00016395-02, NCGC00016395-03, NCGC00178908-01, NCGC00178908-02, 4-(Diphenylmethoxy)-1-(methyl)piperidine, MS-23999, SBI-0051354.P003, DB-367041, HY-107431, AB00053461, CS-0028462, NS00009804, D07862, G12548, AB00053461_14, AB00053461_15, AG-205/36627019, EN300-18530977, L001180, PIPERIDINE, 4-(DIPHENYLMETHOXY)-1-METHYL, Q411150, BRD-K22936972-003-05-3, BRD-K22936972-003-15-2, BRD-K22936972-003-22-8, BRD-K22936972-003-23-6
Theoretical properties:
molecular_formula: C19H23NO
molecular_weight: 281.4 g/mol
exact_mass: 281.177964357 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 4
heavy_atom_count: 21
topological_polar_surface_area: 12.5 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
solubility: 1.88e-02 g/L
Descriptions:
pubchem: Diphenylpyraline is a member of the class of piperidines that is the benzhydryl ether derivative of 1-methyl-4-hydroxypiperidine. A sedating antihistamine, it is used as the hydrochloride for the symptomatic relief of allergic conditions including rhinitis and hay fever, and in pruritic skin disorders. It is also used as the teoclate salt (piprinhydrinate) as an ingredient in compound preparations for the symptomatic relief of coughs and the common cold. It has a role as a H1-receptor antagonist and a cholinergic antagonist. It is a member of piperidines and a tertiary amine.
chebi: A member of the class of  piperidines that is the benzhydryl ether derivative of 1-methyl-4-hydroxypiperidine. A sedating antihistamine, it is used as the hydrochloride for the symptomatic relief of allergic conditions including rhinitis and hay fever, and in pruritic skin disorders. It is also used as the teoclate salt (piprinhydrinate) as an ingredient in compound preparations for the symptomatic relief of coughs and the common cold.
chembl: DIPHENYLPYRALINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Diphenylpyraline (DPP; sold as Allergen, Arbid, Belfene, Diafen, Hispril, Histyn, Lergobine, Lyssipol, Mepiben, Neargal) is a first-generation antihistamine with anticholinergic effects of the diphenylpiperidine class. It is marketed in Europe for the treatment of allergies. DPP has also been found to act as a dopamine reuptake inhibitor and produces hyperactivity in rodents. It has been shown to be useful in the treatment of Parkinsonism.