Compound: praziquantel
SMILES: O=C1N2C(c3c(cccc3)CC2)CN(C1)C(=O)C4CCCCC4
InChIKey: FSVJFNAIGNNGKK-UHFFFAOYSA-N
Synonyms: praziquantel, 55268-74-1, Biltricide, Droncit, Embay 8440, Praziquantelum, Cysticide, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one, prazicuantel, EMBAY-8440, DTXSID9021182, NSC-757285, 4H-Pyrazino(2,1-a)isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-, 2-(Cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino(2,1-a)isoquinolin-4-one, DTXCID501182, Prasiquantel, 6490C9U457, 2-cyclohexanecarbonyl-1H,2H,3H,4H,6H,7H,11bH-piperazino[2,1-a]isoquinolin-4-one, BROADLINE COMPONENT PRAZIQUANTEL, PROFENDER COMPONENT PRAZIQUANTEL, Cisticid, 4H-Pyrazino[2,1-a]isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-, Cestocur, Prazitech, PraziCleanse, GiarCidia Prazi, 2-cyclohexanecarbonyl-1H,2H,3H,4H,6H,7H,11bH-piperazino(2,1-a)isoquinolin-4-one, Praziquantel Tablets, DACTYMOR, Praziquantel Injection, RefChem:55908, Droncit Canine Cestocide, Droncit Feline Cestocide, Durvet Feline Tape Tabs, Tapeworm Dewormer for Cats, CHEBI:45267, P02BA01, TAPEWORM DEWORMER FOR DOGS, Durvet Feline Tape Tabs for Cats, Droncit 5.68% Injectible Solution, Worm and Parasites Aquarium Cure Program Salt, Worm and Parasites Aquarium Cure Program Fresh, Prazi-C Tablets (OTC), Praziquantel Tablets (Rx), 259-559-6, Droncit Canine Cestocide Tablets, Droncit Feline Cestocide Tablets, Praziquantel 34 (Rx), Tapeworm Dewormer for Cats (OTC), Tapeworm Dewormer for Dogs (OTC), Pyquiton, Cesol, Azinox, 2-(cyclohexanecarbonyl)-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one, (+/-)-Praziquantel, Praziquantel (Biltricide), MFCD00058531, 2-(cyclohexanecarbonyl)-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-one, MLS000038419, SMR000037139, Cutter Tape Tabs, 2-(cyclohexanecarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one, Distocide, Prazinon, d-Praziquantel, Praziquantelum [INN-Latin], Cutter, 2-cyclohexanecarbonyl-1H,2H,3H,4H,6H,7H,11bH-pyrazino[2,1-a]isoquinolin-4-one, Biltricide (TN), CCRIS 4114, SR-01000003100, EINECS 259-559-6, 135526-78-2, BRN 0761557, Bay-8440, Praziquantel (JAN/USP/INN), UNII-6490C9U457, NCGC00016877-01, Prestwick_402, CAS-55268-74-1, Praziquantel 100 microg/mL in Acetonitrile, Praziquantel [USAN:USP:INN:BAN:JAN], Spectrum_001119, Praziquantel (Standard), Opera_ID_378, Prestwick0_000260, Prestwick1_000260, Prestwick2_000260, Prestwick3_000260, Spectrum2_001288, Spectrum3_000550, Spectrum4_000482, Spectrum5_001064, PRAZIQUANTEL [MI], PRAZIQUANTEL [INN], PRAZIQUANTEL [JAN], CHEMBL976, P 4668, PRAZIQUANTEL [USAN], cid_4891, PRAZIQUANTEL [VANDF], Lopac0_000909, Oprea1_163497, SCHEMBL44153, BSPBio_000080, BSPBio_002199, KBioGR_000963, KBioSS_001599, PRAZIQUANTEL [MART.], 5-24-03-00361 (Beilstein Handbook Reference), MLS000028528, MLS001201812, MLS001304085, MLS002548849, MLS006011880, DivK1c_000130, PRAZIQUANTEL [USP-RS], PRAZIQUANTEL [WHO-DD], PRAZIQUANTEL [WHO-IP], SPECTRUM1500494, SPBio_001295, SPBio_002299, Praziquantel-(cyclohexyl-d11), BPBio1_000088, orb1308625, orb3025180, SCHEMBL16019896, BDBM74574, CHEBI:91583, HMS500G12, HY-B0244R, KBio1_000130, KBio2_001599, KBio2_004167, KBio2_006735, KBio3_001699, PRAZIQUANTEL [GREEN BOOK], NINDS_000130, GLXC-07070, GLXC-26256, HMS1568D22, HMS1920J06, HMS2090J19, HMS2092A09, HMS2095D22, HMS3259K07, HMS3262F20, HMS3655O19, HMS3712D22, HMS5079N12, Pharmakon1600-01500494, PRAZIQUANTEL [ORANGE BOOK], Praziquantel for system suitability, PRAZIQUANTEL [EP MONOGRAPH], PRAZIQUANTEL [USP IMPURITY], HY-B0244, MSK20471, PRAZIQUANTEL [USP MONOGRAPH], Tox21_110660, Tox21_201950, Tox21_302927, Tox21_500909, CCG-39773, EBC-11170, NSC757285, Praziquantel, anthelminic, neurogenic, s1691, STK030186, PRAZIQUANTELUM [WHO-IP LATIN], AKOS000541869, AKOS016398525, Tox21_110660_1, AC-8426, DB01058, FP27126, LP00909, NC00468, NSC 757285, SB49202, SDCCGSBI-0050884.P005, 2-(Cyclohexylcarbonyl)-1,2,3,6,7-11b-hexahydro-4H-pyrazinoe(2,1a)isoquinolin-4-one, IDI1_000130, NCGC00015818-04, NCGC00015818-05, NCGC00015818-06, NCGC00015818-07, NCGC00015818-08, NCGC00015818-11, NCGC00015818-12, NCGC00015818-14, NCGC00015818-15, NCGC00015818-26, NCGC00089733-02, NCGC00089733-03, NCGC00089733-04, NCGC00089733-05, NCGC00256422-01, NCGC00259499-01, NCGC00261594-01, AS-12459, SY052322, SBI-0050884.P004, DB-052707, PRAZIQUANTEL (EMA EPAR: VETERINARY), AB00052075, EU-0100909, NS00010534, P2125, ST50904686, SW196645-3, C07367, D00471, EN300-123768, AB00052075-13, AB00052075-15, AB00052075_16, AB00052075_17, Praziquantel, VETRANAL(TM), analytical standard, F358136, Q424145, SR-01000003100-3, SR-01000003100-5, SR-01000003100-7, BRD-A21858158-001-05-2, BRD-A21858158-001-16-9, BRD-A21858158-001-22-7, BRD-A21858158-001-23-5, SR-01000003100-16, F0037-0136, Z1554103331, Praziquantel, European Pharmacopoeia (EP) Reference Standard, Praziquantel, United States Pharmacopeia (USP) Reference Standard, 10-(cyclohexylcarbonyl)-5,6,7,11a-tetrahydropiperazino[2,1-a]isoquinolin-8-one, 2-(Cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro- 4H-pyrazino[2,1-a]-isoquinolin-4-one, 2-(Cyclohexylcarbonyl)-1,2,3,6,7-11b-hexahydro-4H-pyrazino[2,1-aisoquinolin-4-one, 2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one, 2-Cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino(2,1-a)isoquinolin-4-one, Praziquantel for system suitability, European Pharmacopoeia (EP) Reference Standard, Praziquantel, Pharmaceutical Secondary Standard; Certified Reference Material, InChI=1/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H
Theoretical properties:
molecular_formula: C19H24N2O2
molecular_weight: 312.4 g/mol
exact_mass: 312.183778013 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 1
heavy_atom_count: 23
topological_polar_surface_area: 40.6 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
melting_point: 136-138 °C
Descriptions:
pubchem: 2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one is a member of isoquinolines.
chembl: PRAZIQUANTEL is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Praziquantel, sold under the brandname Biltricide among others, is a medication used to treat a number of types of parasitic worm infections in mammals, birds, amphibians, reptiles, and fish. In humans specifically, it is used to treat schistosomiasis, clonorchiasis, opisthorchiasis, tapeworm infections, cysticercosis, echinococcosis, paragonimiasis, fasciolopsiasis, and fasciolosis. It should not be used for worm infections of the eye. It is taken by mouth.
Side effects in humans may include poor coordination, abdominal pain, vomiting, headache, and allergic reactions. While it may be used during pregnancy, it is not recommended for use during breastfeeding. Praziquantel is in the anthelmintic class of medications. It works partly by affecting the function of the worm's sucker.
Praziquantel was approved for medical use in the United States in 1982, and in the European Union in April 2025. It is on the World Health Organization's List of Essential Medicines.