Compound: quinolinic acid
SMILES: O=C(O)c1ncccc1C(=O)O
InChIKey: GJAWHXHKYYXBSV-UHFFFAOYSA-N
Synonyms: quinolinic acid, Pyridine-2,3-dicarboxylic acid, 2,3-pyridinedicarboxylic acid, 89-00-9, quinolinate, Pyridine-2,3-dicarboxylate, DTXSID8041327, F6F0HK1URN, NSC-13127, DTXCID6021327, CHEBI:16675, RefChem:389256, CHEBI:132942, 201-874-8, 339155-13-4, MFCD00006295, 2,3-pyridine dicarboxylic acid, pyridinedicarboxylic acid, AI3-63017, pyridine-2,3-carboxylate, 28605-84-7, Pyridin-2,3-dicarbonsaeure, CHEMBL286204, 2,3-pyridinedicarboxylate, SMR000112287, SR-01000075472, EINECS 201-874-8, UNII-F6F0HK1URN, NSC 13127, quinolinic-acid, HSDB 7511, Spectrum_001525, Tocris-0225, pyridine carboxylate, 6c, Spectrum2_000929, Spectrum3_001502, Spectrum4_000336, Spectrum5_001170, Lopac-P63204, bmse000219, EC 201-874-8, pyridine, 2,3-dicarboxy-, Quinolinic acid (Standard), Lopac0_000989, Oprea1_139764, SCHEMBL69230, BSPBio_003143, KBioGR_000711, KBioSS_002005, QUINOLINIC ACID [MI], MLS001332417, MLS001332418, MLS002153210, DivK1c_000773, Pyridine-2,3-dicarboxylicacid, SCHEMBL597255, SPECTRUM1502102, SPBio_000838, orb1303166, orb1692435, orb3141330, pyridine-5,6-dicarboxylic acid, SCHEMBL4413036, SCHEMBL27423283, SCHEMBL29356188, BDBM26115, HMS502G15, KBio1_000773, KBio2_002005, KBio2_004573, KBio2_007141, KBio3_002643, NINDS_000773, HMS1921J12, HMS2267B04, HMS3263E19, HMS3266C15, HMS3411C05, HMS3675C05, HMS3885A17, NSC13127, NSC18836, Moxifloxacin Impurity  cent feminine, Tox21_302051, Tox21_500989, BBL007601, CCG-39677, EBC-03338, HB0544, MSK2070-100M, NSC-18836, NSC403247, PDSP1_000133, PDSP2_000132, s3624, SBB040573, STK365157, 2,3-Pyridinedicarboxylic acid, 99%, AKOS000119760, MSK2070-1000M, CS-W020665, DB01796, FG-0461, FP27303, HY-100807R, LP00989, NSC-403247, PB47350, SDCCGMLS-0411909.P028, SDCCGSBI-0050962.P003, CAS-89-00-9, IDI1_000773, MLS-0411909, NCGC00015865-01, NCGC00015865-02, NCGC00015865-03, NCGC00015865-04, NCGC00015865-05, NCGC00015865-06, NCGC00015865-07, NCGC00015865-08, NCGC00015865-12, NCGC00024506-01, NCGC00024506-02, NCGC00024506-03, NCGC00024506-04, NCGC00024506-05, NCGC00024506-06, NCGC00255468-01, NCGC00261674-01, AC-11734, SY003044, 2,3-Pyridinedicarboxylic acid (8CI,9CI), MLS-0411909.P016, DB-016184, HY-100807, EU-0100989, NS00006026, P0550, ST50213959, EN300-18090, C03722, D70926, P63204, Quinolinic acid Solution in Methanol, 100ug/mL, AC-907/25014157, AE-641/00369043, F049657, Q411945, Quinolinic acid Solution in Methanol, 1000ug/mL, SR-01000075472-1, SR-01000075472-3, BRD-K51885093-001-11-2, Z57160166, F2191-0231, 2,3-Pyridinedicarboxylic acid, Vetec(TM) reagent grade, 98%, InChI=1/C7H5NO4/c9-6(10)4-2-1-3-8-5(4)7(11)12/h1-3H,(H,9,10)(H,11,12
Theoretical properties:
molecular_formula: C7H5NO4
molecular_weight: 167.12 g/mol
exact_mass: 167.02185764 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 2
hydrogen_bond_acceptor_count: 5
rotatable_bond_count: 2
heavy_atom_count: 12
topological_polar_surface_area: 87.5 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
physical_state: Crystals
color: Crystals
odor: Odorless
vapor_pressure: 0.0000061 [mmHg]
Descriptions:
pubchem: Quinolinic acid is a pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan. It has a role as a NMDA receptor agonist, a mouse metabolite, an Escherichia coli metabolite and a human metabolite. It is a conjugate acid of a quinolinate and a quinolinate(1-).
chebi: A pyridinedicarboxylic acid that is pyridine substituted by carboxy groups at positions 2 and 3. It is a metabolite of tryptophan.
chembl: QUINOLINIC ACID is a small molecule listed in the ChEMBL database but has not progressed to an approved clinical phase.
wikipedia: Quinolinic acid (abbreviated QUIN or QA), also known as pyridine-2,3-dicarboxylic acid, is a dicarboxylic acid with a pyridine backbone. It is a colorless solid. It is the biosynthetic precursor to niacin.
Quinolinic acid is a downstream product of the kynurenine pathway, which metabolizes the amino acid tryptophan. It acts as an NMDA receptor agonist.
Quinolinic acid has a potent neurotoxic effect. Studies have demonstrated that quinolinic acid may be involved in many psychiatric disorders, neurodegenerative processes in the brain, as well as other disorders. Within the brain, quinolinic acid is only produced by activated microglia and macrophages.