Compound: biperiden
SMILES: OC(c1ccccc1)(C2C3C=CC(C2)C3)CCN4CCCCC4
InChIKey: YSXKPIUOCJLQIE-UHFFFAOYSA-N
Synonyms: biperiden, 514-65-8, Biperidene, Biperidine, Biperideno, Biperidenum, KL 373, Akineton-, alpha-5-Norbornen-2-yl-alpha-phenyl-1-piperidinepropanol, 0FRP6G56LD, 1-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol, NSC-759145, alpha-bicyclo[2.2.1]hept-5-en-2-yl-alpha-phenyl-1-piperidinepropanol, CHEBI:3112, DTXSID6022680, 1-Piperidinepropanol, alpha-bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl-, 1-{bicyclo[2.2.1]hept-5-en-2-yl}-1-phenyl-3-(piperidin-1-yl)propan-1-ol, alpha-Bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl-1-piperidinepropanol, 1-Bicyclo(2.2.1)hept-5-en-2-yl-1-phenyl-3-piperidin-1-yl-propan-1-ol, 1-Bicyclo[2.2.1]hept-5-en-2-yl-1-phenyl-3-piperidin-1-yl-propan-1-ol, 1-(bicyclo(2.2.1)hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol, Hydrochloride, Biperiden, RefChem:917211, DTXCID802680, N04AA02, 208-184-6, Akineton, Beperiden, Biperidene [INN-French], Biperidenum [INN-Latin], Biperideno [INN-Spanish], 1-Bicycloheptenyl-1-phenyl-3-piperidino-propanol-1, 3-Piperidino-1-phenyl-1-bicycloheptenyl-1-propanol, CHEMBL1101, 1-PIPERIDINEPROPANOL, alpha-5-NORBORNEN-2-YL-alpha-PHENYL-, 3-Piperidino-1-phenyl-1-bicyclo(2.2.1)hepten-(5)-yl-propanol-(1), 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol, Biperiden [USAN:BAN:INN:JAN], 1-Piperidinepropanol, .alpha.-bicyclo[2.2.1]hept-5-en-2-yl-.alpha.-phenyl-, Akineton (TN), 1-Piperidinepropanol, .alpha.-bicyclo[2.2.1]hept-5-en-2-yl-.alpha.-phenyl-, hydrochloride, NCGC00182965-01, EINECS 208-184-6, UNII-0FRP6G56LD, BRN 0290038, Biperiden (JAN/USP/INN), SR-05000001649, HSDB 7639, Biperiden [USP:INN:BAN:JAN], 1-PIPERIDINEPROPANOL, .ALPHA.-BICYCLO(2.2.1)HEPT-5-EN-2-YL-.ALPHA.-PHENYL-, 1-(Bicyclo(2.2.1)hept-5-en-2alpha-yl)-1-phenyl-3-piperidinopropanol, alpha-(Bicyclo(2.2.1)hept-5-en-2-yl)-alpha-phenyl-1-piperidino propanol, 3-Piperidino-1-phenyl-1-bicyclo(2.2.1)hepten-(5)-yl-propanol-(1) [German], Akinophyl (Salt/Mix), BIPERIDEN [INN], BIPERIDEN [JAN], BIPERIDEN [MI], BIPERIDEN [HSDB], 5-Norbornene-2-methanol, alpha-phenyl-alpha-(2-piperidinoethyl)-, Prestwick0_000502, Prestwick1_000502, Prestwick2_000502, BIPERIDEN [VANDF], BIPERIDEN [MART.], BIPERIDEN [WHO-DD], BIPERIDEN [WHO-IP], NCIOpen2_009564, SCHEMBL34957, 5-20-02-00242 (Beilstein Handbook Reference), SPBio_002344, GTPL7128, BIPERIDEN [USP IMPURITY], HMS2093N17, Pharmakon1600-01505514, BIPERIDENUM [WHO-IP LATIN], BDBM50240680, EBC-26737, HY-13204A, NSC759145, PDSP1_000821, PDSP2_000808, STL582281, 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidyl)propan-1-ol, AKOS016008819, CCG-213474, CS-1797, DB00810, NSC 759145, SDCCGSBI-0206797.P002, NCGC00182965-02, NCGC00182965-03, NCGC00182965-04, NCGC00182965-12, DA-71529, SBI-0206797.P001, NS00003936, C07941, D00779, EN300-19997207, L001222, Q414914, SR-05000001649-1, BRD-A00546892-001-01-8, BRD-A00546892-001-02-6, BRD-A00546892-003-05-5, .alpha.-5-Norbornen-2-yl-.alpha.-phenyl-1-piperidinepropanol, a-bicyclo[2.2.1]hept-5-en-2yl-a-phenyl-1-piperidinepropanol, 1-Piperidinepropanol, .alpha.-5-norbornen-2-yl-.alpha.-phenyl-, 1-(2-bicyclo[2.2.1]hept-5-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol, 1-Bicyclo[2.2.1]hept-5-en-2-yl-1-phenyl-3-(1-piperidinyl)-1-propanol #, 5-Norbornene-2-methanol, .alpha.-phenyl-.alpha.-(2-piperidinoethyl)-, .alpha.-(Bicyclo(2.2.1)hept-5-en-2-yl)-.alpha.-phenyl-1-piperidino propanol, Bicyclo[2.2.1]hept-5-ene-2-methanol, .alpha.-phenyl-.alpha.-[2-(1-piperidinyl)ethyl]-
Theoretical properties:
molecular_formula: C21H29NO
molecular_weight: 311.5 g/mol
exact_mass: 311.224914549 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 5
heavy_atom_count: 23
topological_polar_surface_area: 23.5 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
physical_state: Crystals
color: Crystals
Descriptions:
pubchem: Biperiden is a member of the class of piperidines that is N-propylpiperidine in which the methyl hydrogens have been replaced by hydroxy, phenyl, and 5-norbornen-2-yl groups. A muscarinic antagonist affecting both the central and peripheral nervous systems, it is used in the treatment of all forms of Parkinson's disease. It has a role as an antidote to sarin poisoning, an antiparkinson drug, a muscarinic antagonist, a parasympatholytic and an antidyskinesia agent. It is a member of piperidines, a tertiary alcohol and a tertiary amino compound.
chebi: A member of the class of piperidines that is <em>N</em>-propylpiperidine in which the methyl hydrogens have been replaced by hydroxy, phenyl, and 5-norbornen-2-yl groups. A muscarinic antagonist affecting both the central and peripheral nervous systems, it is used in the treatment of all forms of Parkinson's disease.
chembl: BIPERIDEN is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Biperiden, sold under the brand name Akineton among others, is a medication used to treat Parkinson disease, certain drug-induced movement disorders and Tourette Syndrome. It is not recommended for tardive dyskinesias. It is taken by mouth, injection into a vein, or muscle.
Common side effects include blurred vision, dry mouth, sleepiness, constipation, and confusion. It should not be used in people with a bowel obstruction or glaucoma. It is unclear if use in pregnancy or breastfeeding is safe. Biperiden is in the anticholinergic family of medication.
Biperiden was approved for medical use in the United States in 1959. It is on the World Health Organization's List of Essential Medicines. Biperiden is no longer marketed in the United States.