Compound: Clascoterone
SMILES: O=C1C=C2[C@]([C@@H]3[C@H]([C@H]4[C@]([C@@](OC(=O)CC)(C(=O)CO)CC4)(C)CC3)CC2)(C)CC1
InChIKey: GPNHMOZDMYNCPO-PDUMRIMRSA-N
Synonyms: Clascoterone, 19608-29-8, CB-03-01, Cortexolone 17alpha-propionate, Winlevi, breezula, clascoterona, XN7MM8XG2M, 21-Hydroxy-17-(1-oxopropoxy)pregn-4-ene-3,20-dione, Cortodoxone 17alpha-propionate, Pregn-4-ene-3,20-dione, 21-hydroxy-17-(1-oxopropoxy)-, Pregn-4-ene-3,20-dione, 17,21-dihydroxy-, 17-propionate, DTXSID10471883, [(8R,9S,10R,13S,14S,17R)-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate, (1R,3aS,3bR,9aR,9bS,11aS)-1-(2-hydroxyacetyl)-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl propanoate, clascoteronum, ((8R,9S,10R,13S,14S,17R)-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta(a)phenanthren-17-yl) propanoate, (1R,3aS,3bR,9aR,9bS,11aS)-1-(2-hydroxyacetyl)-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta(a)phenanthren-1-yl propanoate, RefChem:54840, DTXCID70422699, 17 alpha-propionate, Clascoterone [USAN], (8R,9S,10R,13S,14S,17R)-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl propionate, Cortexolone 17.alpha.-propionate, Cortodoxone 17.alpha.-propionate, Clascoterone (USAN), 21-HYDROXY-3,20-DIOXOPREGN-4-EN-17-YL PROPANOATE, UNII-XN7MM8XG2M, Winlevi (TN), CLASCOTERONE [MI], CLASCOTERONE [INN], CLASCOTERONE [WHO-DD], orb1304286, orb3141181, SCHEMBL1231152, CHEMBL3590187, Clascoterone - Bio-X trade mark, GTPL11215, CLASCOTERONE [ORANGE BOOK], GLXC-04691, EX-A1953, 11-deoxycortisol 17alpha-propionate, EBC-26959, MSK170224, s6896, AKOS030526694, AT22231, CB-0301, CS-1151, DB12499, AC-31957, BH300086, DA-71981, FH162416, HY-13331, MS-26871, CB-03-01?, clascoterone; 19608-29-8; cb-03-1, NS00070332, D11451, EN300-20605470, BRD-K41779183-001-01-2, BRD-K41779183-001-02-0, Q27293917, Cortexolone 17 alpha-propionate;Cortexolone 17-propionate;CB-03-01, Pregn-4-ene-3,20-dione, 17,21-dihydroxy-, 17-propionate (8CI); 21-Hydroxy-17-(1-oxopropoxy)pregn-4-ene-3,20-dione; Clascoterone; Winlevi
Theoretical properties:
molecular_formula: C24H34O5
molecular_weight: 402.5 g/mol
exact_mass: 402.24062418 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 5
rotatable_bond_count: 5
heavy_atom_count: 29
topological_polar_surface_area: 80.7 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
chembl: CLASCOTERONE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Clascoterone, sold under the brand name Winlevi, is an antiandrogen medication which is used topically in the treatment of acne. The medication is used as a cream by application to the skin, for instance the face and scalp. Clascoterone is an antiandrogen, or antagonist of the androgen receptor (AR), the biological target of androgens such as testosterone and dihydrotestosterone. It shows minimal systemic absorption when applied to skin.
Clascoterone was developed by Cassiopea and was approved for medical use in the United States in August 2020 and in the European Union in October 2025. The US Food and Drug Administration (FDA) considers it to be a first-in-class medication.