Compound: lactulose
SMILES: O1[C@@H](O[C@H]2[C@H](O)[C@@](O)(CO)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]([C@H]1CO)O
InChIKey: JCQLYHFGKNRPGE-FCVZTGTOSA-N
Synonyms: lactulose, D-Lactulose, 4618-18-2, Bifiteral, Cephulac, Chronulac, Constilac, Lactulosa, Acilac, Cholac, Constulose, Lactulosum, Enulose, Generlac, Heptalac, Laxilose, Portalac, Kristalose, Lattulosio, 4-O-beta-D-Galactopyranosyl-D-fructose, Lactulose jp17, 4-galactosyl fructose, DTXSID5045833, 4-O-beta-D-Galactopyranosyl-D-fructofuranose, NSC-757082, 9U7D5QH5AE, D-Fructose, 4-O-beta-D-galactopyranosyl-, CHEBI:6359, DTXCID3025833, (2S,3R,4S,5R,6R)-2-{[(2R,3S,4S,5R)-4,5-dihydroxy-2,5-bis(hydroxymethyl)oxolan-3-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol, Osmolax, Regulose, Lemlax, Laxose orange, Duphalac Dry, Lactulose Solution, (2S,3R,4S,5R,6R)-2-(((2R,3S,4S,5R)-4,5-dihydroxy-2,5-bis(hydroxymethyl)oxolan-3-yl)oxy)-6-(hydroxymethyl)oxane-3,4,5-triol, RefChem:58703, GlyTouCan:G57229GY, A06AD11, G57229GY, Lactulose Solution USP, 10 g/15 mL, beta-D-Galactopyranosyl-(1->4)-D-fructose, 225-027-7, 6-deoxy-3-C-methyl-D-mannose, CHEBI:30983, Evalose, 58166-24-8, 9XH2P2N8EP, Isolactose, Laevolac, 4-O-beta-D-galactopyranosyl-beta-D-fructofuranose, 58166-25-9, Lactulosum [Latin], Lactulosa [Spanish], Lattulosio [Italian], Lactulosum [INN-Latin], Lactulosa [INN-Spanish], (2S,3R,4S,5R,6R)-2-(((2R,3S,4S,5R)-4,5-Dihydroxy-2,5-bis(hydroxymethyl)tetrahydrofuran-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, Actilax, alpha-Lactulose, Cephulac (TN), Lactulose, >95%, 2-[(3S,4S,2R,5R)-2,5-bis(hydroxymethyl)-4,5-dihydroxyoxolan-3-yloxy](2S,4S,3R, 5R,6R)-6-(hydroxymethyl)-2H-3,4,5,6-tetrahydropyran-3,4,5-triol, CAS-4618-18-2, SR-05000002084, EINECS 225-027-7, UNII-9U7D5QH5AE, UNII-9XH2P2N8EP, BRN 0093773, BRN 6278818, 4-beta-D-Galactosido-(1,4)-D-fructose, delta-Lactulose, Lactulose CRS, Chronulac (TN), NCGC00094707-01, beta-D-Fructofuranose, 4-O-beta-D-galactopyranosyl-, Lactulose [USAN:USP:INN:BAN:JAN], 4-O-beta-D-Galattopiranosil-D-fruttofuranosio [Italian], Spectrum_000857, Spectrum2_001159, Spectrum3_000478, Spectrum4_000962, Spectrum5_000908, .ALPHA.-LACTULOSE, 4-O-beta-D-Galattopiranosil-D-fruttofuranosio, SCHEMBL18912, BSPBio_002216, KBioGR_001303, KBioSS_001337, 5-17-07-00214 (Beilstein Handbook Reference), Fructofuranose, 4-O-beta-D-galactopyranosyl-, D-, DivK1c_000064, SPECTRUM1500363, SPBio_001117, Lactulose (JP18/USP/INN), alpha-D-Fructofuranose, 4-o-beta-D-galactopyranosyl-, CHEMBL296306, MLS-50, orb1310281, orb3139768, HMS500D06, KBio1_000064, KBio2_001337, KBio2_003905, KBio2_006473, KBio3_001436, NINDS_000064, HMS1920J03, HMS2094G15, Pharmakon1600-01500363, Tox21_111318, BDBM50377984, CCG-39552, NSC757082, SBB012563, 4-O-b-D-Galactopyranosyl-D-fructose, Lactulose for peak identification CRS, AKOS024283994, Tox21_111318_1, DB00581, NSC 757082, IDI1_000064, NCGC00142624-01, NCGC00142624-02, NCGC00142624-03, NCGC00142624-05, ST072194, 4-O-b-D-galactopyranosyl-D-Fructofuranose, 4-O-beta-delta-Galactopyranosyl-delta-fructose, C07064, D00352, AB00052029_02, EN300-19791535, Q422689, 4-O-beta-delta-galactopyranosyl-delta-Fructofuranose, SR-05000002084-1, SR-05000002084-4, BRD-K77258318-001-04-6, .ALPHA.-D-FRUCTOFURANOSE, 4-O-.BETA.-D-GALACTOPYRANOSYL-, (2S,3R,4S,5R,6R)-2-[(2R,3S,4S,5R)-4,5-dihydroxy-2,5-bis(hydroxymethyl)tetrahydrofuran-3-yl]oxy-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol
Theoretical properties:
molecular_formula: C12H22O11
molecular_weight: 342.30 g/mol
exact_mass: 342.11621151 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 8
hydrogen_bond_acceptor_count: 11
rotatable_bond_count: 5
heavy_atom_count: 23
topological_polar_surface_area: 190 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
solubility: Soluble in cold water, hot water. Solubility in water: 76.4% @ 30 deg. C
Descriptions:
pubchem: Lactulose is a synthetic galactosylfructose disaccharide used in the treatment of constipation and hepatic encephalopathy. It has a role as a laxative and a gastrointestinal drug.
chebi: A synthetic galactosylfructose disaccharide used in the treatment of constipation and hepatic encephalopathy.
chembl: LACTULOSE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Lactulose is a non-absorbable sugar used in the treatment of constipation and hepatic encephalopathy. It is administered orally for constipation, and either orally or rectally for hepatic encephalopathy. It generally begins working after 8–12 hours, but may take up to 2 days to improve constipation.
Common side effects include abdominal bloating and cramps. A potential exists for electrolyte problems as a result of the diarrhea it produces. No evidence of harm to the fetus has been found when used during pregnancy. It is generally regarded as safe during breastfeeding. It is classified as an osmotic laxative.
Lactulose was first made in 1929, and has been used medically since the 1950s. Lactulose is made from the milk sugar lactose, which is composed of two simple sugars, galactose and glucose. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication. In 2023, it was the 266th most commonly prescribed medication in the United States, with more than 900,000 prescriptions.