Compound: Promegestone
SMILES: O=C1C=C2C(=C3[C@H]([C@H]4[C@]([C@](C(=O)CC)(C)CC4)(C)CC3)CC2)CC1
InChIKey: QFFCYTLOTYIJMR-XMGTWHOFSA-N
Synonyms: Promegestone, 34184-77-5, Surgestone, Promegestona, Promegestonum, RU5020, R 5020, RU-5020, 9XE0V2SQYX, R5020, DTXSID4036510, Estra-4,9-dien-3-one, 17-methyl-17-(1-oxopropyl)-, (17beta)-, CHEBI:73390, (17beta)-17-methyl-17-propionylestra-4,9-dien-3-one, (8S,13S,14S,17S)-13,17-dimethyl-17-propanoyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one, Promestone, (8S,13S,14S,17S)-13,17-dimethyl-17-propanoyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta(a)phenanthren-3-one, 17,21-Dimethyl-19-nor-4,9-pregnadiene-3,20-dione, RU 5020, RefChem:176228, DTXCID2016510, G03DB07, Promegestone [INN], Promegestone (INN), [3H]R5020, (8S,13S,14S,17S)-13,17-dimethyl-17-propionyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one, 17alpha-methyl-17-propionylestra-4,9-dien-3-one, 17,21-dimethyl-19-norpregna-4,9(10)-diene-3,20-dione, Promegestonum [INN-Latin], Surgestone (TN), Promegestona [INN-Spanish], UNII-9XE0V2SQYX, R-5020, QFFCYTLOTYIJMR-XMGTWHOFSA-N, PROMEGESTONE [MI], SCHEMBL37770, PROMEGESTONE [MART.], PROMEGESTONE [WHO-DD], 17alpha-Methyl-1,7-propionylestra-4,9-dien-3-one, CHEMBL196003, GTPL2877, orb1695604, Estra-4,9-dien-3-one, 17-alpha-methyl-17-propionyl-, BDBM18660, Estra-4,9-dien-3-one, 17-methyl-17-(1-oxopropyl)-, (17-beta)-, AKOS040753618, AT30553, DB13602, DA-57065, XP183243, HY-119384, CS-0068047, NS00124643, D08431, U-56217, Q7249694, Estra-4,9-dien-3-one, 17-methyl-17-(1-oxopropyl)-, (17|A)-, (10S,11S,14S,15S)-14,15-dimethyl-14-propanoyltetracyclo[8.7.0.0;{2,7}.0;{11,15}]heptadeca-1,6-dien-5-one, (1S,3aS,3bS,11aS)-1,11a-Dimethyl-1-propanoyl-1,2,3,3a,3b,4,5,8,9,10,11,11a-dodecahydro-7H-cyclopenta[a]phenanthren-7-one
Theoretical properties:
molecular_formula: C22H30O2
molecular_weight: 326.5 g/mol
exact_mass: 326.224580195 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 2
heavy_atom_count: 24
topological_polar_surface_area: 34.1 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Promegestone is a progestin consisting of 17beta-propionylestra-4,9-dien-3-one substituted at position 17 by a methyl group. It has a role as an antineoplastic agent, a progestin and a progesterone receptor agonist. It is a 20-oxo steroid and a 3-oxo-Delta(4) steroid. It derives from a hydride of an estrane.
chebi: A progestin consisting of 17β-propionylestra-4,9-dien-3-one substituted at position 17 by a methyl group.
chembl: PROMEGESTONE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 2.0.
wikipedia: Promegestone, sold under the brand name Surgestone, is a progestin medication which is used in menopausal hormone therapy and in the treatment of gynecological disorders. It is taken by mouth.
Side effects of promegestone include menstrual irregularities among others. Promegestone is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has weak antiandrogenic, glucocorticoid, and antimineralocorticoid activity and no other important hormonal activity. The medication is largely a prodrug of trimegestone.
Promegestone was first described in 1973 and was introduced for medical use in France in 1983. It has only been marketed in a few countries, including France, Portugal, Tunisia, and Argentina. In addition to its use as a medication, promegestone has been widely used in scientific research as a radioligand of the progesterone receptor.