Compound: terguride
SMILES: O=C(N(CC)CC)N[C@@H]1CN([C@@H]2Cc3c[nH]c4c3c([C@H]2C1)ccc4)C
InChIKey: JOAHPSVPXZTVEP-YXJHDRRASA-N
Synonyms: terguride, Dironyl, Teluron, 37686-84-3, Tergurida, trans-Dihydrolisuride, Transdihydrolisuride, Terguride [INN], (+)-Terguride, Terguridum, Terguridum [Latin], Tergurida [Spanish], (5R,8S,10R)-Terguride, DTXSID3045809, (+)-(5R,8S,10R)-Terguride, 9,10-alpha-Dihydrolisuride, Teluron (TN), 21OJT43Q88, TERGURIDE [JAN], TERGURIDE [MI], EINECS 253-624-2, TERGURIDE [MART.], TERGURIDE [WHO-DD], BRN 0766582, ZK 31224, DTXCID1025809, 6-Methyl-8alpha-(diethylcarbamoylamino)ergoline, 1,1-Diethyl-3-(6-methylergolin-8alpha-yl)urea, Terguridum (Latin), N,N-Diethyl-N'-(D-6-methyl-10alpha-isoergolin-8-yl)urea, 1-((5R,8S,10R)-6-Methyl-8-ergolinyl)-3,3-diethylurea, TERGURIDE (MART.), 1,1-DIETHYL-3-(6-METHYLERGOLIN-8.ALPHA.-YL)UREA, Urea, N,N-diethyl-N'-((8-alpha)-6-methylergolin-8-yl)-, 3-[(6aR,9S,10aR)-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-yl]-1,1-diethylurea, VUFB 6638, 3,3-diethyl-1-((2R,4S,7R)-6-methyl-6,11-diazatetracyclo(7.6.1.0^(2,7).0^(12,16))hexadeca-1(16),9,12,14-tetraen-4-yl)urea, 3,3-diethyl-1-[(2R,4S,7R)-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),9,12,14-tetraen-4-yl]urea, 3-((6aR,9S,10aR)-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo(4,3-fg)quinoline-9-yl)-1,1-diethylurea, RefChem:891401, N-(D-6-methyl-8-isoergolin-1-yl)-N',N'-diethylurea, G02CB06, urea, N,N-diethyl-N'-((8 alpha)-6-methylergolin-8-yl)-, (Z)-2-butenedioate (1:1), 253-624-2, TDHL, trans-Dihydro Lisuride, CHEMBL73151, MLS000069833, Mysalfon, SMR000058934, 1,1-diethyl-3-(6-methyl-8alpha-ergolinyl)urea, 3-[(6aR,9S,10aR)-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinolin-9-yl]-1,1-diethylurea, S(+)-Terguride, UNII-21OJT43Q88, NCGC00094476-03, Tergurid; Terguride; trans-Dihydrolisuride, CAS-37686-84-3, Terguride (JAN/INN), Opera_ID_1172, Prestwick0_000945, Prestwick1_000945, Prestwick2_000945, Prestwick3_000927, GTPL56, BSPBio_000834, SCHEMBL147259, SPBio_003069, BPBio1_000918, orb1737647, SCHEMBL30402886, CHEBI:32193, HMS1570N12, HMS2232H10, Tox21_111283, BDBM50017519, AKOS037653997, DB13399, KS-1464, NCGC00179409-02, HY-12714, AB00514698, CS-0012291, NS00030264, 8alpha-(3,3-diethylureido)-6-methylergoline, D01348, N,N-Diethyl-N'-(6-methylergolin-8alpha-yl)urea, Q7702355, s(+)-N,N-Diethyl-n([8alpha]-6-methylergolin-8-yl)urea, 1,1-Diethyl-3-(7-methyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinolin-9-yl)-urea
Theoretical properties:
molecular_formula: C20H28N4O
molecular_weight: 340.5 g/mol
exact_mass: 340.22631153 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 2
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 3
heavy_atom_count: 25
topological_polar_surface_area: 51.4 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
solubility: 14.1 [ug/mL] (The mean of the results at pH 7.4)
Descriptions:
pubchem: Terguride is an organic molecular entity.
chembl: TERGURIDE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 2.0.
wikipedia: Terguride (INNTooltip International Nonproprietary Name, JANTooltip Japanese Accepted Name), sold under the brand name Teluron, is a serotonin receptor antagonist and dopamine receptor agonist of the ergoline family. It is approved for and used as a prolactin inhibitor in the treatment of hyperprolactinemia (high prolactin levels) in Japan. Terguride is taken by mouth.