Compound: Quifenadine
SMILES: OC(c1ccccc1)(c2ccccc2)C3C4CCN(C3)CC4
InChIKey: PZMAHNDJABQWGS-UHFFFAOYSA-N
Synonyms: Quifenadine, 10447-39-9, Quifenadinum, quifenadina, alpha,alpha-Diphenyl-3-quinuclidinemethanol, W9A18RJ49B, DTXSID6046187, DTXCID4026187, {1-azabicyclo[2.2.2]octan-3-yl}diphenylmethanol, (1-azabicyclo(2.2.2)octan-3-yl)diphenylmethanol, quinuclidinyl-3-diphenylcarbinol, RefChem:178137, R06AX31, Quifenadine [INN], Diphenyl(quinuclidin-3-yl)methanol, 1-azabicyclo[2.2.2]octan-3-yl(diphenyl)methanol, 1-azabicyclo[2.2.2]oct-3-yl(diphenyl)methanol, Fenkarol, Quifenadine (INN), NCGC00160492-01, .alpha.,.alpha.-Diphenyl-3-quinuclidinemethanol, (3-QUINUCLIDINYL)DIPHENYL CARBINOL HYDROCHLORIDE, Quifenadino, Quifenadinum [INN-Latin], Quifenadino [INN-Spanish], Benzhydrol, alpha-(3-quinuclidinyl)-, BRN 1542055, UNII-W9A18RJ49B, alpha,alpha-Diphenyl-3-chinuclidinylmethanol, Diphenyl-3-quinuclidylcarbinol; alpha,alpha-Diphenyl-3-quinuclidinemethanol, 1-Azabicyclo[2.2.2]octane-3-methanol,a,a-diphenyl-, 1-Azabicyclo(2.2.2)octane-3-methanol, alpha,alpha-diphenyl-, 3-Quinuclidinemethanol, alpha,alpha-diphenyl-, Fencarol [as hydrochloride], Oprea1_250552, Phencarol [as hydrochloride], QUIFENADINE [WHO-DD], MLS006011470, orb1705311, SCHEMBL1813124, CHEMBL1187694, CHEBI:134746, PZMAHNDJABQWGS-UHFFFAOYSA-N, Tox21_111852, BBL022956, MFCD01684913, STK697937, AKOS001668833, AKOS022061528, DB13713, Benzhydrol, .alpha.-(3-quinuclidinyl)-, NCGC00160492-02, SMR002499074, VS-07290, CAS-10447-39-9, HY-122761, CS-0088847, D10230, AB00637982-07, 3-Quinuclidinemethanol, .alpha.,.alpha.-diphenyl-, AG-205/05218021, Q4497981, (1-Azabicyclo[2.2.2]octan-3-yl)di(phenyl)methanol
Theoretical properties:
molecular_formula: C20H23NO
molecular_weight: 293.4 g/mol
exact_mass: 293.177964357 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 3
heavy_atom_count: 22
topological_polar_surface_area: 23.5 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
{"pubchem": "Quifenadine is a diarylmethane.", "chebi": null, "chembl": "QUIFENADINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 2.0.", "wikipedia": "Quifenadine (Russian: \u0445\u0438\u0444\u0435\u043d\u0430\u0434\u0438\u043d, trade name: Fenkarol, \u0424\u0435\u043d\u043a\u0430\u0440\u043e\u043b) is a 2nd generation antihistamine drug, marketed mainly in post-Soviet countries. Chemically, it is a quinuclidine derivative.\nThe drug has antiarrhythmic properties, probably due to the presence of a quinuclidine nucleus in the molecule's core. It acts as a calcium channel blocker and influences the activity of potassium channels. In children with cardiac arrhythmia, combination therapy with quifenadone and either amiodarone or propafenone was found to be more effective than monotherapy with either amiodarone or propafenone.\nQuifenadine is a derivative of quinuclidylcarbinol, which reduces the effects of histamine on organs and systems. Quifenadine is a competitive blocker of H1 receptors. In addition, it activates the diamine oxidase enzyme, which breaks down about 30% of endogenous histamine. This explains the effectiveness of quifenadine in patients insensitive to other antihistamines. The antihistaminic qualities of quifenadine are associated with the presence of a cyclic quinuclidine core in the structure and the distance between the diphenylcarbinol group and the nitrogen atom. In terms of antihistaminic activity and duration of action, quifenadine is superior to diphenhydramine. Quifenadine reduces the toxic effect of histamine, eliminates or weakens its bronchoconstrictor effect and spasmodic effect on the smooth muscles of the intestines, has a moderate antiserotonin and weak cholinolytic effect, has well-defined antipruritic and desensitizing properties. Quifenadine weakens the hypotensive effect of histamine and its effect on capillary permeability, does not directly affect cardiac activity and blood pressure, does not have a protective effect in aconitine arrhythmias.\n\n"}