Compound: Bicine
SMILES: O=C(O)CN(CCO)CCO
InChIKey: FSVCELGFZIQNCK-UHFFFAOYSA-N
Synonyms: Bicine, 150-25-4, N,N-Bis(2-hydroxyethyl)glycine, Diethylolglycine, Diethanol glycine, Dihydroxyethylglycine, Bicene, Glycine, N,N-bis(2-hydroxyethyl)-, 2-(bis(2-hydroxyethyl)amino)acetic acid, N,N-Dihydroxyethyl glycine, N,N-Dihydroxyethylglycine, DHEG, 2-[bis(2-hydroxyethyl)amino]acetic acid, di(hydroxyethyl)glycine, 1J484QFI1O, NSC-7342, NSC-7512, CHEBI:40957, RefChem:568038, CHEBI:39065, 205-755-1, N,N-Di(2-hydroxyethyl)glycine, Fe-3-Specific, Bis(2-Hydroxyethyl)glycine, N,N-(2-Hydroxyethyl)glycine, Diethanolglycine, MFCD00004295, N,N-Bis(2-hydroxyethyl)aminoacetic acid, N,N-(2-Dihydroxyethyl)glycine, N,N-Bis(beta-hydroxyethyl)glycine, NSC 7342, GLYCINE, N,N-DIHYDROXYETHYL-, N,N-Bis(hydroxyethyl)glycine, Bicine (cell culture suitable), n,n-bis-(2-hydroxyethyl)-glycine, bicine buffer, N,N-Bis(.beta.-hydroxyethyl)glycine, Glycine,N-dihydroxyethyl-, WLN: QV1N2Q2Q, Glycine,N-bis(2-hydroxyethyl)-, Chelest GA; DHEG;NSC 7342; NSC 7512;Diethanol glycine, 2-HxG, EINECS 205-755-1, BRN 1769362, UNII-1J484QFI1O, BICINE [MI], N,N-di(hydroxyethyl)glycine, SCHEMBL34161, 4-04-00-02390 (Beilstein Handbook Reference), di(hydroxyethyl)aminoacetic acid, orb1306037, CHEMBL1231251, DTXSID3041669, BICINE, >=99% (titration), N,N-bis(2-hydroxyethyl)glycine], NSC7342, NSC7512, N,N-bis(2-hydroxyethyl)-Glycine, HMS3604E14, HY-D0868, AC8058, BBL011024, EBC-47240, s6276, SBB057746, STK802165, AKOS005622671, n,n-bis(2-hydroxyethyl)glycine bicine, DB03709, FB11031, [Bis(2-hydroxyethyl)amino]acetic acid #, BICINE, BioUltra, >=99.5% (T), BICINE, BioXtra, >=99% (titration), NCGC00342441-01, AS-12494, DA-55872, N,N-Bis(2-hydroxyethyl)glycine (Bicine), N,N-Bis-(2-hydroxyethyl)aminoacetic acid, SY010805, N,N-bis-(2-hydroxyethyl) aminoacetic acid, N,N-DI(HYDROXYETHYL)AMINOACETIC ACID, B0484, CS-0015178, N,N-BIS(HYDROXYETHYL)AMINOACETIC ACID, NS00003493, ST50308630, AB00443773-03, EN300-7244555, F045147, Q4903636, 3-Azapentanoic acid, 5-hydroxy-3-(2-hydroxyethyl)-, Z336127920, Glycine, N,N-bis(2-hydroxyethyl)-;Glycine, N,N-dihydroxyethyl-
Theoretical properties:
molecular_formula: C6H13NO4
molecular_weight: 163.17 g/mol
exact_mass: 163.08445790 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 3
hydrogen_bond_acceptor_count: 5
rotatable_bond_count: 6
heavy_atom_count: 11
topological_polar_surface_area: 81 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: N,N-bis(2-hydroxyethyl)glycine is a bicine that is a Good's buffer substance, pKa = 8.35 at 20 C. It is a conjugate acid of a [bis(2-hydroxyethyl)amino]acetate. It is a tautomer of a [bis(2-hydroxyethyl)ammonio]acetate.
chebi: A bicine that is amino acetate in which the nitrogen atom is substituted by 2 (2-hydroxyethyl)- groups.
chembl: BICINE is a small molecule listed in the ChEMBL database but has not progressed to an approved clinical phase.
wikipedia: Bicine is an organic compound used as a buffering agent.  It is one of Good's buffers and has a pKa of 8.35 at 20 °C.  It is prepared by the reaction of glycine with ethylene oxide, followed by hydrolysis of the resultant lactone.
Bicine is a contaminant in amine systems used for gas sweetening. It is formed by amine degradation in the presence of O2, SO2, H2S or Thiosulfate.