Compound: minoxidil
SMILES: [O-][n+]1c(nc(N2CCCCC2)cc1N)N
InChIKey: ZFMITUMMTDLWHR-UHFFFAOYSA-N
Synonyms: minoxidil, 38304-91-5, Rogaine, Loniten, Minoximen, Theroxidil, Alopexil, Alostil, Regaine, Tricoxidil, Lonolox, Normoxidil, Prexidil, Minodyl, Pierminox, RiUP, Mintop, U-10858, 3-hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amine, 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide, 2,4-Pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide, 6-(1-piperidinyl)-2,4-pyrimidinediamine-3-oxide, U-10,858, 6-Amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine, NSC-757106, 6-(piperidin-1-yl)pyrimidine-2,4-diamine 3-oxide, 3-hydroxy-2-imino-6-(1-piperidyl)pyrimidin-4-amine, MLS000028566, CHEBI:6942, DTXSID9040685, Minossidile [Italian], MFCD00063409, 2,6-diamino-4-(piperidin-1-yl)pyrimidin-1-ium-1-olate, Minoxidilum [INN-Latin], NCGC00015673-08, Minoxidilum, SMR000058963, CAS-38304-91-5, Apo-Gain, 6-Piperidin-1-ylpyrimidine-2,4-diamine 3-oxide, DTXCID7020685, Neoxidil, Avacor and Mintop, 2,4-Diamino-6-piperidinopyrimidine 3-oxide, 2,6-diamino-4-piperidylpyrimidin-1-ol, SMR000326812, Loniten (TN), Rogaine (TN), Riup (TN), SR-01000075331, SR-05000001479, 2,4-Diamino-6-piperidinopyrimidine 3-N-oxide, Minoxidil CRS, Regaine For Men, Regaine For Women, Prestwick_521, TM-160, Men''''s Rogaine, Women''''s rogaine, Rogaine Extra Strength, Spectrum_000969, Tocris-0583, MINOXIDIL [INN], MINOXIDIL [JAN], MINOXIDIL [MI], Minoxidil Extra Strength, MINOXIDIL [HSDB], MINOXIDIL [USAN], regid855572, Opera_ID_1150, Prestwick0_000020, Prestwick1_000020, Prestwick2_000020, Prestwick3_000020, Spectrum2_001053, Spectrum3_000509, Spectrum4_000063, Spectrum5_001299, Lopac-M-4145, MINOXIDIL [VANDF], M1389, CHEMBL802, MINOXIDIL [MART.], M 4145, MINOXIDIL [USP-RS], MINOXIDIL [WHO-DD], Minoxidil (U-10858), Minoxidil (JAN/USP/INN), CBiol_001798, Lopac0_000786, SCHEMBL29698, BSPBio_000059, BSPBio_001385, BSPBio_002037, KBioGR_000105, KBioGR_000585, KBioSS_000105, KBioSS_001449, MLS000859953, MLS001077294, DivK1c_000160, SPECTRUM1500415, Minoxidil - Bio-X trade mark, SPBio_001006, SPBio_001980, BPBio1_000065, CHEMBL609587, GTPL4254, Minoxidil, >=99% (TLC), SGCUT00112, MINOXIDIL [ORANGE BOOK], CHEMBL1372483, MINOXIDIL [EP MONOGRAPH], SCHEMBL29365549, BCBcMAP01_000193, BDBM81463, CHEBI:92128, HMS500H22, KBio1_000160, KBio2_000105, KBio2_001449, KBio2_002673, KBio2_004017, KBio2_005241, KBio2_006585, KBio3_000209, KBio3_000210, KBio3_001537, MINOXIDIL [USP MONOGRAPH], NINDS_000160, ZFMITUMMTDLWHR-UHFFFAOYSA-N, Bio1_000084, Bio1_000573, Bio1_001062, Bio2_000105, Bio2_000585, DTXSID301372970, HMS1361F07, HMS1568C21, HMS1791F07, HMS1920P03, HMS1989F07, HMS2089L08, HMS2091F20, HMS2095C21, HMS2233E04, HMS2235N21, HMS3259P21, HMS3262M14, HMS3266O06, HMS3371E15, HMS3372M19, HMS3402F07, HMS3411G16, HMS3675G16, HMS3712C21, Pharmakon1600-01500415, 6-amino-2-imino-4-(piperidin-1-yl)-1,2-dihydropyrimidin-1-ol, CAS_4201, HY-B0112, NSC_4201, to_000070, VQB71866, Tox21_110193, Tox21_500786, BDBM50237593, CCG-40112, EBC-06508, HB1094, MFCD00072128, Minoxidil for system suitability CRS, MSK000473, NSC757106, s1383, SBB056986, STL453211, AKOS015920078, AKOS016339636, Tox21_110193_1, AC-5271, CCG-220020, CS-1867, DB00350, FD26009, GS-3605, KS-5164, LP00786, NC00686, SDCCGSBI-0050764.P005, IDI1_000160, IDI1_033855, SMP1_000192, NCGC00015673-01, NCGC00015673-02, NCGC00015673-03, NCGC00015673-04, NCGC00015673-05, NCGC00015673-06, NCGC00015673-07, NCGC00015673-09, NCGC00015673-10, NCGC00015673-11, NCGC00015673-13, NCGC00015673-20, NCGC00018278-01, NCGC00018278-02, NCGC00018278-03, NCGC00018278-04, NCGC00024666-01, NCGC00024666-02, NCGC00024666-03, NCGC00024666-04, NCGC00024666-05, NCGC00024666-06, NCGC00024666-07, NCGC00024666-08, NCGC00179672-01, NCGC00261471-01, BD164673, PD003089, SY075383, SBI-0050764.P004, 2,6-Diamino-4-piperidinopyrimidine 1-Oxide, 5965120SH1, AB00513797, EU-0100786, NS00014997, ST50993884, D00418, EN300-121204, H10337, O10620, U10858, AB00052047-08, AB00052047_09, AB00052047_10, AB00513797-02, Q424165, SR-01000075331-1, SR-01000075331-3, SR-01000075331-5, SR-05000001479-1, SR-05000001479-2, 2,4-DIAMINO-6-PIPERIDINOPYRIMIDINE 3-OXIDE., BRD-K06902185-001-05-2, BRD-K06902185-001-10-2, BRD-K06902185-001-16-9, BRD-K06902185-001-17-7, BRD-K06902185-003-01-7, BRD-K14888893-001-02-3, BRD-K14888893-001-14-8, Minoxidil, British Pharmacopoeia (BP) Reference Standard, Z1541638524, Minoxidil, European Pharmacopoeia (EP) Reference Standard, 1-Oxo-4-(piperidin-1-yl)-1lambda~5~-pyrimidine-2,6-diamine, 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidino-pyrimidine, Minoxidil, United States Pharmacopeia (USP) Reference Standard, Minoxidil for system suitability, European Pharmacopoeia (EP) Reference Standard
Theoretical properties:
molecular_formula: C9H15N5O
molecular_weight: 209.25 g/mol
exact_mass: 209.12766012 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 3
hydrogen_bond_acceptor_count: 3
rotatable_bond_count: 1
heavy_atom_count: 15
topological_polar_surface_area: 88.9 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
solubility: >31.4 [ug/mL] (The mean of the results at pH 7.4)
Descriptions:
pubchem: Minoxidil is a pyrimidine N-oxide that is pyrimidine-2,4-diamine 3-oxide substituted by a piperidin-1-yl group at position 6. It has a role as a vasodilator agent and an antihypertensive agent. It is a member of piperidines, an aminopyrimidine and a pyrimidine N-oxide.
chebi: A pyrimidine <em>N</em>-oxide that is pyrimidine-2,4-diamine 3-oxide substituted by a piperidin-1-yl group at position 6.
chembl: MINOXIDIL is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Minoxidil, sold under the brand names Loniten and Rogaine among others, is a medication used for the treatment of high blood pressure and pattern hair loss. It is an antihypertensive and a vasodilator. It is available as a generic medication by prescription in oral tablet form and over-the-counter as a topical liquid or foam.