Compound: betahistine
SMILES: n1c(cccc1)CCNC
InChIKey: UUQMNUMQCIQDMZ-UHFFFAOYSA-N
Synonyms: betahistine, 5638-76-6, N-Methyl-2-pyridineethanamine, Vasomotal, 2-Pyridineethanamine, N-methyl-, Betahistina, 2-[2-(Methylamino)ethyl]pyridine, N-methyl-2-pyridin-2-ylethanamine, Betahistinum, methyl[2-(pyridin-2-yl)ethyl]amine, Betaistina, 2-(2-(Methylamino)ethyl)pyridine, Vestibo, (2-(2-Pyridyl)ethyl)methylamine, [2-(2-Pyridyl)ethyl]methylamine, 2-(beta-Methylaminoethyl)pyridine, HISTALEAN, X32KK4201D, N-Methyl-2-(2-pyridinyl)ethanamine, NSC-42617, DTXSID3022665, CHEBI:35677, methyl(2-(pyridin-2-yl)ethyl)amine, Betahistine Methanesulphonate, By Vertin, Betahistine Biphar, Betahistin ratiopharm, Mesylate, Betahistine, RefChem:388835, Hydrochloride, Betahistine, Dihydrobromide, Betahistine, Dihydrochloride, Betahistine, Methanesulfonate, Betahistine, Methanesulphonate, Betahistine, DTXCID202665, N07CA01, 227-086-4, Betahistine Methanesulfonate, 2-(2-METHYLAMINOETHYL)PYRIDINE, N-methyl-2-(pyridin-2-yl)ethanamine, beta-Histine, Serc base, PT 9 base, Sinmenier (free base), N-Methyl-2-pyridineethylamine, MFCD00006362, Pyridine, 2-(2-methylaminoethyl)-, NSC 42617, N-Methyl-N-(2-pyridin-2-ylethyl)amine, N-methyl-2-(2-pyridyl)ethanamine, Pyridine, 2-[2-(methylamino)ethyl]-, CHEMBL24441, N-Methyl-2-(pyridin-2-yl)ethan-1-amine, Betahistine (INN), BETAHISTINE [INN], PYRIDINE, 2-(2-(METHYLAMINO)ETHYL)-, Betaistina [DCIT], methyl(2-(2-pyridyl)ethyl)amine, Betahistine [INN:BAN], Betahistinum [INN-Latin], Betahistina [INN-Spanish], Betahistine free base, 5638-76-6 (free base), EINECS 227-086-4, N-Methyl-N-beta-(2-pyridyl)ethylamine, BRN 0112294, N-Methyl-N-[2-(2-pyridyl)ethyl]amine, UNII-X32KK4201D, Betahistine;, Betahistine?, Ethyl nipicotate, .beta.-Histine, Vestibo (TN), Methyl-(2-pyridin-2-yl-ethyl)-amine, Spectrum_000274, BETAHISTINE [MI], Betahistine dihdrochloride, Prestwick0_000543, Prestwick1_000543, Prestwick2_000543, Prestwick3_000543, Spectrum2_001191, Spectrum3_001735, Spectrum4_000254, Spectrum5_001393, BETAHISTINE [VANDF], EC 227-086-4, 2-(methylaminoethyl)pyridine, BETAHISTINE [MART.], (2-Methylaminoethyl)pyridine, BETAHISTINE [WHO-DD], BSPBio_000585, BSPBio_003410, KBioGR_000688, KBioSS_000754, methyl(2-pyridinyl)ethylamine, MLS000028903, DivK1c_000602, SCHEMBL125582, SCHEMBL375097, SPBio_001261, SPBio_002506, BPBio1_000645, cid_203875, N-Methyl-2-pyridineethanamine;, OBE101, orb1303073, SCHEMBL1477284, SCHEMBL6890812, SCHEMBL18226631, SCHEMBL29354603, 2-(2(methylamino)ethyl)pyridine, 2-(2-methylaminoethyl) pyridine, BDBM96589, GTPL11937, KBio1_000602, KBio2_000754, KBio2_003322, KBio2_005890, KBio3_002630, EX-A921, NINDS_000602, 2-(2-methylamino-ethyl)-pyridine, HMS3886O12, HMS5085M03, HY-B0524, Methyl-(2-pyridin-2-ylethyl)amine, N-methyl-2-pyridin-2-ylethaneamine, NSC42617, 2-(.beta.-Methylaminoethyl)pyridine, 2-[2-(N-methylamino)ethyl]pyridine, AR1013, BBL004908, EBC-03965, methyl-(2-pyridin-2-yl-ethyl)amine, s5619, SBB040053, STK801447, AKOS000255727, N-methyl-2-(pyridine-2-yl)ethanamine, 2-(2-Methylaminoethyl)pyridine, 97%, CCG-266132, DB06698, N-Methyl-2-(2-pyridinyl)ethanamine #, PS-4217, SB17406, SB37365, IDI1_000602, NCGC00093362-02, NCGC00093362-03, N-Methyl-N-.beta.-(2-pyridyl)ethylamine, SMR000059096, SY106727, SBI-0051588.P003, DB-052905, AB00053577, CS-0009496, NS00006018, ST50213092, EN300-17834, D07522, methyl-[2-(2-pyridyl)ethyl]amine;hydrochloride, AB00053577_12, AB00053577_13, N-methyl-2-(2-pyridinyl)ethanamine;hydrochloride, N-methyl-2-pyridin-2-yl-ethanamine;hydrochloride, F065480, Q368995, BRD-K91315211-300-02-4, BRD-K91315211-300-05-7, BRD-K91315211-300-06-5, BRD-K91315211-334-02-3, F2158-0901, Betahistine Dihydrochloride Working Standard (Secondary Reference Standard)
Theoretical properties:
molecular_formula: C8H12N2
molecular_weight: 136.19 g/mol
exact_mass: 136.100048391 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 3
heavy_atom_count: 10
topological_polar_surface_area: 24.9 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
boiling_point: 210.9±15.0 °C
melting_point: 150-144
Descriptions:
pubchem: Betahistine is an aminoalkylpyridine that is pyridine substituted by a 2-(methylamino)ethyl group at position 2. It acts as a histamine agonist and a vasodilator, and is thought to improve the microcirculation of the labyrinth, resulting in reduced endolymphatic pressure. It is used (generally as the hydrochloride or mesylate salt) to reduce the symptoms of vertigo, tinnitus, and hearing loss associated with Mnire's disease. It has a role as a vasodilator agent and a H1-receptor agonist. It is an aminoalkylpyridine and a secondary amino compound.
chebi: An aminoalkylpyridine that is pyridine substituted by a 2-(methylamino)ethyl group at position 2. It acts as a histamine agonist and a vasodilator, and is thought to improve the microcirculation of the labyrinth, resulting in reduced endolymphatic pressure. It is used (generally as the hydrochloride or mesylate salt) to reduce the symptoms of vertigo, tinnitus, and hearing loss associated with Ménière's disease.
chembl: BETAHISTINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 2.0.
wikipedia: Betahistine, sold under the brand name Serc among others, is an anti-vertigo medication. It is commonly prescribed for balance disorders or to alleviate vertigo symptoms. It was first registered in Europe in 1970 for the treatment of Ménière's disease, but current evidence does not support its efficacy in treating it.