Compound: tolazoline
SMILES: N1=C(NCC1)Cc2ccccc2
InChIKey: JIVZKJJQOZQXQB-UHFFFAOYSA-N
Synonyms: tolazoline, 59-98-3, 2-Benzylimidazoline, 2-Benzyl-4,5-dihydro-1H-imidazole, Benzazoline, 2-Benzyl-2-imidazoline, 2-Benzyl-4,5-imidazoline, Tolazolina, Tolazine, Tolazolinum, 4,5-Dihydro-2-(phenylmethyl)-1H-imidazole, 1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)-, CHH9H12AQ3, NSC-35110, Benzalolin, DTXSID3023683, CHEBI:28502, RefChem:56141, DTXCID103683, C04AB02, M02AX02, 200-448-9, Olitensol, Prefaxil, Vasodilatan, Artonil, Kasimid, Lambril, Priscol, Vasimid, Vasodil, Priscoline, Benzolin, Imidalin, Phenylmethylimidazoline, Benzylimidazoline, Divascol, Peripherine, Tolazolin, Dilatol ASI, Ciba 3259, 2-IMIDAZOLINE, 2-BENZYL-, Benzolin (vasodilator), MFCD00005182, NSC 35110, Tolazoline (INN), Imidaline; NSC35110, Imidaline, Benzolin (VAN), TOLAZOLINE [INN], Tolazoline [INN:BAN], Tolazolinum [INN-Latin], Tolazolina [INN-Spanish], Benzolin (vasodilator) (VAN), CAS-59-97-2, NCGC00016271-01, EINECS 200-448-9, UNII-CHH9H12AQ3, BRN 0128757, Tolazine [veterinary] (TN), Spectrum_000731, TOLAZOLINE [MI], 2-(phenylmethyl)-4,5-dihydro-1H-imidazole, Prestwick0_000060, Prestwick1_000060, Prestwick2_000060, Prestwick3_000060, Spectrum2_001204, Spectrum3_000594, Spectrum4_000357, Spectrum5_001788, TOLAZOLINE [VANDF], CHEMBL770, 2-Benzylimidazoline, 99%, cid_6048, TOLAZOLINE [WHO-DD], SCHEMBL34961, BSPBio_000219, BSPBio_002068, KBioGR_000793, KBioSS_001211, 5-23-06-00488 (Beilstein Handbook Reference), DivK1c_000328, SPBio_000988, SPBio_002140, BPBio1_000241, GTPL7310, orb1306356, SCHEMBL5326165, SCHEMBL5357011, WLN: T5M CN BUTJ B1R, BDBM55436, KBio1_000328, KBio2_001211, KBio2_003779, KBio2_006347, KBio3_001568, NINDS_000328, HY-A0066, MSK10082, NSC35110, 2-benzyl-2-imidazoline;hydrochloride, BBL027502, EBC-26111, FD7203, SBB003964, STL362893, AKOS000357643, CS-3181, DB00797, 2-Benzyl-4,5-dihydro-1H-imidazole #, IDI1_000328, NCGC00016271-02, NCGC00016271-03, AS-49302, SY051649, SBI-0051536.P003, 1H-Imidazole,5-dihydro-2-(phenylmethyl)-, DB-053506, B3806, NS00003680, ST45026160, C07147, D08614, EN300-304854, AB00053555-12, AB00053555_14, L000960, Q413772, BRD-K46211610-003-05-1, BRD-K46211610-003-15-0, BRD-K46211610-003-25-9, BRD-K46211610-003-26-7, 2-(phenylmethyl)-4,5-dihydro-1H-imidazole;hydrochloride
Theoretical properties:
molecular_formula: C10H12N2
molecular_weight: 160.22 g/mol
exact_mass: 160.100048391 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 1
rotatable_bond_count: 2
heavy_atom_count: 12
topological_polar_surface_area: 24.4 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Tolazoline is a member of the class of imidazoles that is 4,5-dihydro-1H-imidazole substituted by a benzyl group. It has a role as a vasodilator agent, an antihypertensive agent and an alpha-adrenergic antagonist.
chebi: A member of the class of imidazoles that is 4,5-dihydro-1<em>H</em>-imidazole substituted by a benzyl group.
chembl: TOLAZOLINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Tolazoline is a non-selective competitive α2-adrenergic receptor antagonist. It is a vasodilator that is used to treat spasms of peripheral blood vessels (as in acrocyanosis). It has also been used (in conjunction with sodium nitroprusside) successfully as an antidote to reverse the severe peripheral vasoconstriction which can occur as a result of overdose with certain 5-HT2A receptor agonist drugs such as 25I-NBOMe, DOB, and Bromodragonfly.