Compound: Azapropazone
SMILES: O=C1N2N(c3c(ccc(c3)C)N=C2N(C)C)C(C1CCC)=O
InChIKey: MPHPHYZQRGLTBO-UHFFFAOYSA-N
Synonyms: Azapropazone, APAZONE, Cinnopropazone, 13539-59-8, Azapropazona, Azapropazonum, Azapropazon, AHR-3018, Mi-85, NSC-102824, K2VOT966ZI, 3-Dimethylamino-7-methyl-1,2-(n-propylmalonyl)-1,2-dihydro-1,2,4-benzotriazine, 5-(Dimethylamino)-9-methyl-2-propyl-1H-pyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2H)-dione, 5-(Dimethylamino)-9-methyl-2-propyl-1H-pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2H)-dione, DTXSID6045408, 1,2-Dihydro-3-dimethylamino-7-methyl-1,2-(propylmalonyl)-1,2,4-benzotriazine, NSC102824, MI-85DI, 1H-Pyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2H)-dione, 5-(dimethylamino)-9-methyl-2-propyl-, DTXCID6023735, CHEBI:38010, 1H-Pyrazolo[1,2-a][1,2,4]benzotriazine-1,3(2H)-dione, 5-(dimethylamino)-9-methyl-2-propyl-, Dihydrate, Apazone, Rheumox 600, RefChem:916574, M01AX04, 236-913-8, Prolixan, Cinnamin, Sinnamin, Rheumox, Prolix, Xani, Azapropazone (anhydrous), Apazone [USAN], Prolixan 300, MI 85, AHR 3018, Azapropazon [German], NSC 102824, Azapropazone [INN], MLS002703748, Apazone (USAN), Azapropazone (INN), Azapropazon (German), 5-(dimethylamino)-9-methyl-2-propyl-1H-benzo[e]pyrazolo[1,2-a][1,2,4]triazine-1,3(2H)-dione, 5-(dimethylamino)-9-methyl-2-propylpyrazolo[1,2-a][1,2,4]benzotriazine-1,3-dione, AHR-3018;NSC-102824;NSC102824;, Azapropazonum [INN-Latin], Azapropazona [INN-Spanish], SMR001233401, EINECS 236-913-8, UNII-K2VOT966ZI, BRN 0623763, NCGC00016701-01, Prolixan (TN), CAS-13539-59-8, Tolyprin (Salt/Mix), APAZONE [MI], Prestwick0_001003, Prestwick1_001003, Prestwick2_001003, Prestwick3_001003, SCHEMBL3190, NCIOpen2_007171, AZAPROPAZONE [MART.], BSPBio_001125, MLS002154093, (+/-)-APAZONE, Apazone dihydrate (Salt/Mix), AZAPROPAZONE [WHO-DD], SPBio_003006, BPBio1_001239, orb1701133, APAZONE, (+/-)-, CHEMBL1565476, SCHEMBL29399203, HMS1571I07, HMS2098I07, HMS2231L14, HMS3372M10, HMS3715I07, NAA53959, Tox21_110569, AKOS015914210, CCG-221003, NCGC00179297-01, NCGC00179297-04, DA-61364, 1,2-(propylmalonyl)-1,2,4-benzotriazine, HY-116442, AB00513995, CS-0065495, NS00009426, D02966, Q368222, SR-01000838825, SR-01000838825-2, BRD-A70182876-001-10-8, WLN: T B566 BNV EVN HN DHJ D3 GN1&1 L1, 3-Dimethylamino-7-methyl-1,2-dihydro-1,2,4-benzotriazine, 3-Dimethylamino-7-methyl-1-2-(N-propylmalonyl)-1,2,4-benzotriazine, 1,2-Dihydro-3-(dimethylamino)-7-methyl-1,2-(propylmalonyl)-1,2,4-benzotriazine, 1H-Pyrazolo[1,2,4]benzotriazine-1,3(2H)-dione, 5-(dimethylamine)-9-methyl-2-propyl-, 1H-Pyrazolo[1,2,4]benzotriazine-1,3(2H)-dione, 5-(dimethylamino)-9-methyl-2-propyl-, 5-(Dimethylamino)-9-methyl-2-propyl-1H-pyrazolo[1,2,4]benzotriazine-1,3(2H)-dione, 5-(Dimethylamino)-9-methyl-2-propyl-1H-pyrazolo[1,2,4]benzotriazine-1,3(2H)dione, 5-(dimethylamino)-9-methyl-2-propyl-pyrazolo[1,2-a][1,2,4]benzotriazine-1,3-dione, 1H-Pyrazolo(1,2-a)(1,2,4)benzotriazine-1,3(2H)-dione, 5-(dimethylamine)-9-methyl-2-propyl-, 5-DIMETHYLAMINO-9-METHYL-2-PROPYLPYRAZOLO(1,2-A)(1,2,4)BENZOTRIAZINE-1,3(2H)-DIONE
Theoretical properties:
molecular_formula: C16H20N4O2
molecular_weight: 300.36 g/mol
exact_mass: 300.15862589 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 3
rotatable_bond_count: 3
heavy_atom_count: 22
topological_polar_surface_area: 56.2 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Apazone is a member of the class of benzotriazines that is 1,2-dihydro-1,2,4-benzotriazine bearing a dimethylamino substitutent at position 3 and a methyl substituent at position 7 and in which the nitrogens at positions 1 and 2 are both acylated by a carboxy group of propylmalonic acid. It has a role as a non-steroidal anti-inflammatory drug and a uricosuric drug. It derives from a hydride of a 1,2,4-benzotriazine.
chebi: A member of the class of benzotriazines that is 1,2-dihydro-1,2,4-benzotriazine bearing a dimethylamino substitutent at position 3 and a methyl substituent at position 7 and in which the nitrogens at positions 1 and 2 are both acylated by a carboxy group of propylmalonic acid.
chembl: APAZONE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 2.0.
wikipedia: Azapropazone  is a nonsteroidal anti-inflammatory drug (NSAID). It is manufactured by Goldshield under the tradename Rheumox. 
It was available in the UK as a prescription-only drug, with restrictions due to certain contra-indications and side-effects. Azopropazone has now been discontinued in the British National Formulary.
Azapropazone has a half-life of approximately 20 hours in humans and is not extensively metabolized.