Compound: Melitracene
SMILES: N(CCC=C1c2c(cccc2)C(C)(C)c3c1cccc3)(C)C
InChIKey: GWWLWDURRGNSRS-UHFFFAOYSA-N
Synonyms: Melitracene, RefChem:156391, N,N-dimethyl-3-(9,10-dihydro-10,10-dimethylanthracen-9-yliden)propylamine, Melitracen, 5118-29-6, Melitracen [INN], Melitraceno, Adelax, Dixeran, 1-Propanamine, 3-(10,10-dimethyl-9(10H)-anthracenylidene)-N,N-dimethyl-, Thymeol, Trausabun, Q7T0Y1109Z, Melitracen (INN), 3-(10,10-dimethylanthracen-9(10H)-ylidene)-N,N-dimethylpropan-1-amine, Melitracenum, Melitracene [INN-French], Melitracenum [INN-Latin], Melitraceno [INN-Spanish], NSC78229, NCGC00181088-01, EINECS 225-858-5, U-24973, BRN 1980107, UNII-Q7T0Y1109Z, Adelax (TN), MELITRACEN [MI], 3-(10,10-dimethylanthracen-9-ylidene)-N,N-dimethylpropan-1-amine, Thymeo (*hydrochloride*), N,N,10,10-Tetramethyl-delta(sup 9(10),gamma)-anthracenepropylamine, 9-(3-Dimetilaminopropyliden)-10,10-dimetil-9,10-diidroanthracene [Italian], MELITRACEN [WHO-DD], NCIOpen2_008949, SCHEMBL48975, Melitracene (*hydrochloride*), N 7001 (*Hydrochloride*), CHEMBL110094, orb1705860, DTXSID4048274, SCHEMBL29984590, U 24973 (*Hydrochloride*), CHEBI:135214, BDBM112783, U-24,973A (*Hydrochloride*), 9-(3-Dimetilaminopropyliden)-10,10-dimetil-9,10-diidroanthracene, Melitracen (USAN)(*hydrochloride*), 3-(10,10-Dimethyl-9(10H)-anthracenylidene)-N,N-dimethyl-1-propanamine, AKOS025311490, delta-(sup 9(10),gamma)-Anthracenepropylamine, N,N,10,10-tetramethyl-, DB13384, 1-Propanamine, 3-(10,10-dimethyl-9(10H)-anthracenylidene)-N,N-dimethyl- (9CI), DA-55332, US8629135, SW-14, HY-121778, CS-0083286, NS00007601, D08171, Q411251, 3-(10,10-dimethyl-9-anthrylidene)-N,N-dimethyl-propan-1-amine, N-(3-(10,10-Dimethyl-9(10H)-anthracenylidene)propyl)-N,N-dimethylamine, .delta.(sup9(10H)),.gamma.-anthracenepropylamine, N,N,10, 10-tetramethyl-, hydrochloride, .DELTA.9(10H), .gamma.-Anthracenepropylamine, N,N,10,10-tetramethyl-, hydrochloride, {9-[(3-Dimethylamino)propylidene]-10,10-dimethyl-9,} 10-dihydroanthracene hydrochloride, 1-Propanamine, 3-(10, 10-dimethyl-9(10H)-anthracenylidene)-N,N-dimethyl-, 1-Propanamine, 3-(10, 10-dimethyl-9(10H)-anthracenylidene)-N,N-dimethyl-, hydrochloride, N,N,10, 10-Tetramethyl-.delta.(sup9(10H)),.gamma.-anthracenepropylamine hydrochloride, N,N,10, 10-Tetramethyl-.DELTA.9(10H), .gamma.-anthracenepropylamine hydrochloride, N,N,10,10-Tetramethyl-.delta.9(10H), .gamma.-anthracenepropylamine, hydrochloride
Theoretical properties:
molecular_formula: C21H25N
molecular_weight: 291.4 g/mol
exact_mass: 291.198699802 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 1
rotatable_bond_count: 3
heavy_atom_count: 22
topological_polar_surface_area: 3.2 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Melitracen is a member of anthracenes.
chembl: MELITRACEN is a small molecule listed in the ChEMBL database and has reached clinical trial phase 3.0.
wikipedia: Melitracen (brand names Melixeran, Trausabun) is a tricyclic antidepressant (TCA), for the treatment of depression and anxiety. In addition to single drug preparations, it is also available as Deanxit, marketed by Lundbeck, a combination product containing both melitracen and flupentixol.
The pharmacology of melitracen has not been properly investigated and is largely unknown, but it is likely to act in a similar manner to other TCAs. Indeed, melitracen is reported to have imipramine and amitriptyline-like effects and efficacy against depression and anxiety, though with improved tolerability and a somewhat faster onset of action.