Compound: Azelnidipine
SMILES: O=[N+]([O-])c1cc(ccc1)C2C(=C(NC(=C2C(=O)OC(C)C)C)N)C(=O)OC3CN(C(c4ccccc4)c5ccccc5)C3
InChIKey: ZKFQEACEUNWPMT-UHFFFAOYSA-N
Synonyms: Azelnidipine, 123524-52-7, Calblock, CS-905, Azelnidipino, DTXSID3020120, PV23P19YUG, CS905, DTXCID50120, 3,5-Pyridinedicarboxylic acid, 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl) 5-(1-methylethyl) ester, (+-)-, 3-[1-(DIPHENYLMETHYL)AZETIDIN-3-YL] 5-PROPAN-2-YL 2-AMINO-6-METHYL-4-(3-NITROPHENYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE, azelnidipinum, 3-(1-(diphenylmethyl)azetidin-3-yl) 5-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, RefChem:560476, 3-(1-diphenylmethylazetidin-3-yl)-5-isopropyl-2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate, 3-(1-(Diphenylmethyl)azetidin-3-yl) 5-(1-methylethyl) (4RS)-2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, 3-(1-Benzhydrylazetidin-3-yl) 5-isopropyl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, Azelnidipine [INN], CS 905, MFCD00865803, C33H34N4O6, 3,5-PYRIDINEDICARBOXYLIC ACID, 2-AMINO-1,4-DIHYDRO-6-METHYL-4-(3-NITROPHENYL)-, 3-[1-(DIPHENYLMETHYL)-3-AZETIDINYL] 5-(1-METHYLETHYL) ESTER, 3-O-(1-benzhydrylazetidin-3-yl) 5-O-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, NCGC00167436-01, NCGC00167436-02, 2-Amino-1,4-dihydro-6-methyl-4-(3 nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[1-(diphenylmethyl)-3-azetidinyl] 5-(1-methylethyl) ester, CAS-123524-52-7, UNII-PV23P19YUG, CCRIS 8650, ZKFQEACEUNWPMT-UHFFFAOYSA-N, Calblock (TN), RS-9054, Azelnidipine (Standard), AZELNIDIPINE [MI], AZELNIDIPINE [JAN], Azelnidipine (JP17/INN), SCHEMBL49021, AZELNIDIPINE [MART.], AZELNIDIPINE [WHO-DD], orb1310917, CHEMBL1275868, SCHEMBL29349688, CHEBI:31247, HY-B0023R, GLXC-05195, HMS3651D18, HMS3885M05, HMS5081G10, HY-B0023, Tox21_112440, s3053, AKOS015841674, Tox21_112440_1, AC-2151, CCG-270140, CS-0949, DB09230, EBC-111068, FA18072, KS-1248, PB24693, Azelnidipine, >=98% (HPLC), powder, 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-amino-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl) 5-(1-methylethyl) ester, (+-)-, 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2-amino-6-methyl-4-(3-nitrophenyl)-, 3-(1-(diphenylmethyl)-3-azetidinyl)-5-(1-methylethyl) esster, (+-)-, 3-(1-(Diphenylmethyl)-3-azetidinyl) 5-isopropyl (+-)-2-amino-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate, 3-[1-(diphenylmethyl)azetidin-3-yl] 5-(1-methylethyl) 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, O3-(1-benzhydrylazetidin-3-yl) O5-isopropyl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, SY055273, A2433, SW219236-1, D01145, SBI-0654212.0001, AB01565841_02, SR-01000944916, Q4832365, SR-01000944916-1, BRD-A01098288-001-02-9, BRD-A01098288-001-04-5, BRD-A01098288-001-06-0, (+/-)-2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(1-diphenylmethylazetidin-3-yl) ester 5-isopropyl ester, (+/-)-2-Amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[1-(diphenylmethyl)-3-azetidinyl] 5-(1-methylethy  l) ester, 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(1-diphenylmethylazetidin-3-yl)ester 5-isopropyl ester, 2-Amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-[1-(Diphenylmethyl)-3-azetidinyl] 5-Isopropyl Ester, 3-(1-(DIPHENYLMETHYL)-3-AZETIDINYL) 5-ISOPROPYL (+/-)-2-AMINO-1,4-DIHYDRO-6-METHYL-4-(M-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLATE, 3-[1-(Diphenylmethyl)-3-azetidinyl] 5-Isopropyl 2-Amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate, 3-[1-(Diphenylmethyl)azetidin-3-yl] 5-(propan-2-yl) 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Theoretical properties:
molecular_formula: C33H34N4O6
molecular_weight: 582.6 g/mol
exact_mass: 582.24783482 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 2
hydrogen_bond_acceptor_count: 9
rotatable_bond_count: 10
heavy_atom_count: 43
topological_polar_surface_area: 140 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
melting_point: 193-195
solubility: Insoluble in water
Descriptions:
pubchem: Azelnidipine is an isopropyl ester.
chembl: AZELNIDIPINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 3.0.
wikipedia: Azelnidipine (INN; marketed under the brand name CalBlock — カルブロック) is a dihydropyridine calcium channel blocker. Azelnidipine is L and T calcium channel blocker. 
It is sold in Japan by Daiichi-Sankyo pharmaceuticals, Inc.
Drug Controller General Of India (DCGI) has approved the use of azelnipine in India. It is launched under the brand name Azusa (ajanta pharma ltd.) In 2020.
Unlike nicardipine, it has a gradual onset and has a long-lasting antihypertensive effect, with little increase in heart rate.