Compound: minaprine
SMILES: O1CCN(CCNc2nnc(-c3ccccc3)cc2C)CC1
InChIKey: LDMWSLGGVTVJPG-UHFFFAOYSA-N
Synonyms: minaprine, 25905-77-5, Cantor, Minaprina, Minaprinum, AGR 1240, N-(4-Methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine, Agr-1240, 4-Morpholineethanamine, N-(4-methyl-6-phenyl-3-pyridazinyl)-, 4-Methyl-3-(2-morpholinoethylamino)-6-phenylpyridazin, CB 30038, 4-(2-((4-Methyl-6-phenyl-3-pyridazinyl)amino)ethyl)morpholine, 4-methyl-N-[2-(morpholin-4-yl)ethyl]-6-phenylpyridazin-3-amine, 00U7GX0NLM, CB-30038, DTXSID5048477, CHEBI:51038, 4-[2-[(4-Methyl-6-phenyl-3-pyridazinyl)amino]ethyl]morpholine, 4-methyl-N-(2-(morpholin-4-yl)ethyl)-6-phenylpyridazin-3-amine, 3-(morpholinoethyl)amino-4-methyl-6-phenylpyridazine, RefChem:925914, DTXCID5028451, N06AX07, 3-(2-morpholino-ethylamino)-4-methyl-6-phenyl pyridazine, dihydrochloride, 247-329-8, Minaprinum [INN-Latin], Minaprina [INN-Spanish], 4-methyl-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine, CHEMBL278819, Brantur, CHEMBL536932, Cantor (TN), Minaprine (USAN/INN), EINECS 247-329-8, CAS-25953-17-7, UNII-00U7GX0NLM, Minaprine [USAN:INN:BAN], 4-methyl-N-(2-morpholinoethyl)-6-phenylpyridazin-3-amine, 25905-77-5 (free base), Spectrum_001334, MINAPRINE [INN], MINAPRINE [MI], MINAPRINE [USAN], Prestwick0_000066, Prestwick1_000066, Prestwick2_000066, Prestwick3_000066, Spectrum2_001407, Spectrum3_001445, Spectrum4_000418, Spectrum5_001593, MINAPRINE [WHO-DD], SCHEMBL49371, BSPBio_000251, BSPBio_002909, KBioGR_000716, KBioSS_001814, DivK1c_000063, SPBio_001454, SPBio_002172, BPBio1_000277, orb1710720, KBio1_000063, KBio2_001814, KBio2_004382, KBio2_006950, KBio3_002409, NINDS_000063, HY-B0884, BDBM50074289, EBC-26515, MFCD00865474, AKOS024287006, CS-4346, DB00805, IDI1_000063, NCGC00016795-01, NCGC00016795-02, NCGC00016795-03, NCGC00016795-04, ST098270, TS-07640, SBI-0051647.P002, DB-046791, AB00053599, NS00003076, T0338, D05039, AB00053599_13, EN300-18531463, L001202, Q6863173, BRD-K02867583-300-05-5, BRD-K02867583-300-06-3, BRD-K02867583-300-08-9, 3-(2-Morpholinoethylamino)-4-methyl-6-phenylpyridazine, 4-methyl-N-(2-morpholinoethyl)-6-phenyl-pyridazin-3-amine, (4-methyl-6-phenylpyridazin-3-yl)(2-morpholin-4-ylethyl)amine, 4-Methyl-N-[2-(4-morpholinyl)ethyl]-6-phenyl-3-pyridazinamine #, (4-Methyl-6-phenyl-pyridazin-3-yl)-(2-morpholin-4-yl-ethyl)-amine; hydrochloride
Theoretical properties:
molecular_formula: C17H22N4O
molecular_weight: 298.4 g/mol
exact_mass: 298.17936134 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 5
rotatable_bond_count: 5
heavy_atom_count: 22
topological_polar_surface_area: 50.3 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Minaprine is a secondary amine, a member of pyridazines and a member of morpholines. It has a role as an antidepressant, a cholinergic drug, an antiparkinson drug, a serotonin uptake inhibitor and a dopamine uptake inhibitor.
chembl: MINAPRINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Minaprine (INN, USAN, BAN; brand names Brantur, Cantor) is a monoamine oxidase inhibitor antidepressant drug that was used in France for the treatment of depression until it was withdrawn from the market in 1996 because it caused convulsions.
A study found that it acts as a reversible inhibitor of MAO-A (RIMA) in rats. It has also been found to weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates. 
It has demonstrated significant antibiotic activity against M. chelonae and M. abscessus in tests with antibiotic resistant bacteria.