Compound: rolipram
SMILES: O=C1NCC(C1)c2cc(OC3CCCC3)c(OC)cc2
InChIKey: HJORMJIFDVBMOB-UHFFFAOYSA-N
Synonyms: rolipram, 61413-54-5, (R,S)-rolipram, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one, ZK 62711, Rolipramum, ZK-62711, 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one, NSC-760125, 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinone, ZK 62 711, SB-95952, ZK-62771, K676NL63N7, CHEBI:104872, (+-)-rolipram, Pyrrolidone, 4-(3-cyclopentyloxy-4-methoxyphenyl)-2-, ZK62711, RefChem:389268, 262-771-1, (+/-)-Rolipram, Rolipramum [Latin], Adeo, 4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one, MFCD00270906, DTXSID3044124, 4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone, CHEMBL63, SB 95952, MLS000069691, 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, s1430, 4-[3-(cyclopentoxy)-4-methoxy-phenyl]pyrrolidin-2-one, SMR000058510, (R,S)-Rolipram;SB 95952;ZK 62711, 4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolidin-2-one, DTXCID1024124, 2-Pyrrolidinone, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-, (4R)-4-[3-(Cyclopentyloxy)-4 Methoxyphenyl)pyrrolidin-2-one, (4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-pyrrolidin-2-one, Rolipram [USAN:INN], R-(-)-Rolipram, [3H]rolipram, [3H]-rolipram, SR-01000000162, EINECS 262-771-1, ME-3167, BRN 1588548, UNII-K676NL63N7, Rolipram?, (plusmn)-rolipram, NCGC00016899-01, CAS-61413-54-5, Rolipram (Standard), ROLIPRAM [USAN], ROLIPRAM [INN], ROLIPRAM [JAN], ROLIPRAM [MI], Opera_ID_1749, Prestwick0_000924, Prestwick1_000924, Prestwick2_000924, Prestwick3_000924, ROLIPRAM [MART.], ROLIPRAM [WHO-DD], UPCMLD-DP110, Lopac0_001072, SCHEMBL27930, BSPBio_000828, BSPBio_001356, KBioGR_000076, KBioSS_000076, Rolipram (JAN/USAN/INN), MLS000758273, MLS000759531, MLS001146912, MLS001424084, MLS006010272, SPBio_003007, BPBio1_000912, GTPL5260, GTPL5313, orb1300590, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinon, SCHEMBL29360376, UPCMLD-DP110:001, UPCMLD-DP110:002, BDBM14361, KBio2_000076, KBio2_002644, KBio2_005212, KBio3_000151, KBio3_000152, Bio2_000076, Bio2_000556, GLXC-06145, HMS1361D18, HMS1570J10, HMS1791D18, HMS1989D18, HMS2051N15, HMS2090J16, HMS2097J10, HMS2232F06, HMS3263G06, HMS3267A05, HMS3369J08, HMS3393N15, HMS3402D18, HMS3411F08, HMS3654P06, HMS3655J21, HMS3675F08, HMS3714J10, HMS5079G04, HMS5080M14, Pharmakon1600-01505683, Tox21_110672, Tox21_501072, BDBM50639239, EBC-11175, EX-A10913, HB2896, HY-16900R, MSK169324, NSC760125, Rolipram, solid, >=98% (HPLC), Rolipram - CAS 61413-54-5, AKOS015959793, Tox21_110672_1, ( inverted exclamation markA)-Rolipram, CCG-100965, CCG-205149, CS-1754, DB01954, FR01270, KS-1400, LP01072, MSK169324-100M, NC00215, NSC 760125, SB12922, SDCCGSBI-0051042.P003, IDI1_033826, NCGC00015898-03, NCGC00015898-04, NCGC00015898-05, NCGC00015898-06, NCGC00015898-07, NCGC00015898-08, NCGC00015898-09, NCGC00015898-11, NCGC00015898-12, NCGC00015898-15, NCGC00015898-31, NCGC00089796-02, NCGC00089796-04, NCGC00089796-05, NCGC00089796-06, NCGC00089796-07, NCGC00089796-08, NCGC00261757-01, AC-32927, HY-16900, Rolipram Solution in Methanol, 100ug/mL, SY012737, SBI-0051042.P002, DB-080675, AB00513966, EU-0101072, NS00034678, R0110, ST50405218, SW196583-4, D01783, R 6520, AB00384360-17, AB00384360_19, Q410285, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidinone, SR-01000000162-3, SR-01000000162-4, SR-01000000162-5, SR-01000000162-9, 4-[3-Cyclopentyloxy-4-methoxyphenyl]-2-pyrrolidinone, BRD-A34255068-001-04-8, BRD-A34255068-001-26-1, BRD-A34255068-001-32-9, BRD-A34255068-001-33-7, BRD-A34255068-001-34-5, SR-01000000162-12, 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrolidin-2-one, 4-(3-cyclopentyloxy-4-methoxyphenyl)-pyrrolidin-2-one, 4-(3-CYCLOPENTYLOXY-4-METHOXYPHENYL)PYRROLIDONE, 4-[4-Methoxy-3-(cyclopentyloxy)phenyl]-2-pyrrolidinone, 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]- (9CI)
Theoretical properties:
molecular_formula: C16H21NO3
molecular_weight: 275.34 g/mol
exact_mass: 275.15214353 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 3
rotatable_bond_count: 4
heavy_atom_count: 20
topological_polar_surface_area: 47.6 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
{"pubchem": "Rolipram is a member of the lclass of pyrrolidin-2-ones that is pyrrolidin-2-one bearing a 3-(cyclopentyloxy)-4-methoxyphenyl substituent at the 4-position. It is a type IV-specific phosphodiesterase (PDE4) inhibitor. It has a role as an antidepressant and an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor.", "chebi": "A member of the lclass of pyrrolidin-2-ones that is pyrrolidin-2-one bearing a 3-(cyclopentyloxy)-4-methoxyphenyl substituent at the 4-position.  It is a type IV-specific phosphodiesterase (PDE4) inhibitor.", "chembl": "ROLIPRAM is a small molecule listed in the ChEMBL database and has reached clinical trial phase 2.0.", "wikipedia": "Rolipram is a selective phosphodiesterase-4 inhibitor discovered and developed by Schering AG as a potential antidepressant drug in the early 1990s.  It served as a prototype molecule for several companies' drug discovery and development efforts.  Rolipram was discontinued after clinical trials showed that its therapeutic window was too narrow; it could not be dosed at high enough levels to be effective without causing significant gastrointestinal side effects.\nRolipram has several activities that make it a continuing focus for research.  The etiology of many neurodegenerative diseases involves misfolded and clumped proteins which accumulate in the brain. Cells have a mechanism to dispose of such proteins called the proteasome.  However, in Alzheimer's disease and some other conditions the activity of these proteasomes is impaired leading to a buildup of toxic aggregates. Research in mice suggests that rolipram has the ability to ramp up the activity of proteasomes and reduce the burden of these aggregates. Preliminary evidence suggests that this can improve spatial memory in mice engineered to have aggregate build-up. Rolipram continues to be used in research as a well-characterized PDE4 inhibitor.  It has been used in studies to understand whether PDE4 inhibition could be useful in autoimmune diseases,  Alzheimer's disease, cognitive enhancement, spinal cord injury, and respiratory diseases like asthma and COPD."}