Compound: Licarbazepine
SMILES: O=C(N1c2c(cccc2)C(O)Cc3c1cccc3)N
InChIKey: BMPDWHIDQYTSHX-UHFFFAOYSA-N
Synonyms: Licarbazepine, 29331-92-8, 10-Hydroxycarbazepine, licarbazepina, XFX1A5KJ3V, 10,11-Dihydro-10-hydroxy-5H-dibenz(b,f)azepine-5-carboxamide, CHEBI:701, 10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide, DTXSID50865484, licarbazepinum, RefChem:153361, DTXCID70813886, 10,11-MHD, 10-hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide, 10,11-Dihydro-10-hydroxycarbamazepine, 10-Hydroxycarbamazepine, 10-OH-Carbazepine, GP 47779, 10,11-Dihydro-10-hydroxy Carbamazepine, 10-Hydroxy-10,11-dihydrocarbamazepine, 10,11-DIHYDRO-10-HYDROXYCARBAZEPINE, Licarbazepine [INN], MFCD00871817, 5H-Dibenz[b,f]azepine-5-carboxamide, 10,11-dihydro-10-hydroxy-, BIA 2-005, 10-HYDROXY-CARBAMAZEPINE, CHEMBL1067, GP-47779, 5H-Dibenz(b,f)azepine-5-carboxamide, 10,11-dihydro-10-hydroxy-, UNII-XFX1A5KJ3V, 10-Hydroxy-10,11-dihydro-5H-dibenz(b,f)azepine-5-carboxamide, Licarbazepine (Standard), Epitope ID:423618, SCHEMBL420263, LICARBAZEPINE [WHO-DD], orb1299489, orb3141229, SCHEMBL12356854, SCHEMBL29802374, HMS3412J19, HMS3676J19, MSK10748, (+-)-10,11-Dihydro-10-hydroxy-5H-dibenz(b,f)azepine-5-carboxamide, BDBM50330859, AKOS016011140, AB92454, FD21950, HY-108506R, SB46355, 10-Hydroxy-10,11-dihydrocarbamez epine, AC-37004, AS-10186, DA-64960, SY108611, HY-108506, CS-0029029, NS00010437, C07493, 10,11-Dihydro-10-hydroxycarbazepine-d4(major), F319986, Q6542996, BRD-A22642447-001-01-9, 10,11-Dihydro-10-hydroxycarbamazepine, analytical standard, 10,11-Dihydro-10-hydroxy Carbamazepine-with exact weight protocol, 10-Hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepine-5 carboxamide, 10-Hydroxy-10,11-dihydrocarbamazepine 1.0 mg/ml in Acetonitrile, 10,11-Dihydro-10-hydroxycarbamazepine 100 microg/mL in Acetonitrile, 10-Hydroxy-10,11-dihydro-dibenzo[b,f]azepine-5-carboxylic acid amide, racemic 10-hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide, 10-Hydroxy-10,11-dihydrocarbamazepine, 10-Hydroxy-10,11-dihydrocarbamezepine, 10,11-Dihydro-10-hydroxycarbamazepine, BIA 2-005, GP 47779, Licarbazepine, 10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide, BIA 2-005, 10,11-Dihydro-10-hydroxycarbamazepine, 10-Hydroxy-10,11-dihydrocarbamezepine,10-Hydroxy-10,11-dihydrocarbamazepine, 10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide, GP 47779, Licarbazepine
Theoretical properties:
molecular_formula: C15H14N2O2
molecular_weight: 254.28 g/mol
exact_mass: 254.105527694 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 2
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 0
heavy_atom_count: 19
topological_polar_surface_area: 66.6 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Licarbazepine is a dibenzoazepine that is 5H-dibenzo[b,f]azepine, reduced across the C-10,11 positions and carrying a carbamoyl substituent at the azepine nitrogen and a hydroxy function at C-10. A voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects, it is related to oxcarbazepine and is an active metabolite of oxcarbazepine. It has a role as an anticonvulsant, a sodium channel blocker and a drug allergen. It is a carboxamide, a dibenzoazepine and a member of ureas. It is functionally related to a carbamazepine.
chebi: A dibenzoazepine that is 5<em>H</em>-dibenzo[<em>b</em>,<em>f</em>]azepine, reduced across the C-10,11 positions and carrying a carbamoyl substituent at the azepine nitrogen and a hydroxy function at C-10. A voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects, it is related to oxcarbazepine and is an active metabolite of oxcarbazepine.
chembl: LICARBAZEPINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 3.0.
wikipedia: Licarbazepine is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects that is related to oxcarbazepine. It is an active metabolite of oxcarbazepine. In addition, an enantiomer of licarbazepine, eslicarbazepine ((S)-(+)-licarbazepine), is an active metabolite of eslicarbazepine acetate. Oxcarbazepine and eslicarbazepine acetate are inactive on their own, and behave instead as prodrugs to licarbazepine and eslicarbazepine, respectively, to produce their therapeutic effects.