Compound: Oripavine
SMILES: O1c2c(O)ccc3c2[C@@]45[C@@H]1C(OC)=CC=C4[C@H](N(C)CC5)C3
InChIKey: ZKLXUUYLEHCAMF-UUWFMWQGSA-N
Synonyms: Oripavine, 467-04-9, 575AOU51CR, IDS-NO-010, DTXSID10196908, 6,7,8,14-Tetradehydro-4,5-alpha-epoxy-6-methoxy-17-methyl-morphinan-3-ol, O(3)-Dimethylthebaine, RefChem:168518, DTXCID10119399, (4R,7aR,12bS)-7-methoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro(3,2-e)isoquinoline-9-ol, (4R,7aR,12bS)-7-methoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro(3,2-e)isoquinolin-9-ol, 207-385-6, 6-demethoxythebaine, EINECS 207-385-6, 3-O-Demethylthebaine, BRN 0046094, Oripavine (1.0mg/ml in Acetonitrile), UNII-575AOU51CR, 6,7,8,14-Tetradehydro-4,5alpha-epoxy-6-methoxy-17-methylmorphinan-3-ol (Oripavine), Oripavine, 50 mg, Codeine Impurity 18, ORIPAVINE [MI], (5alpha)-6,7,8,14-Tetradehydro-4,5-epoxy-6-methoxy-17-methylmorphinan-3-ol, SCHEMBL37889, 4-27-00-02270 (Beilstein Handbook Reference), CHEBI:7782, CHEMBL437602, DEA No. 9330, SCHEMBL29407171, HSDB 8324, Morphinan-3-ol, 6,7,8,14-tetradehydro-4,5-epoxy-6-methoxy-17-methyl-, (5.alpha.)-, Oripavine 0.1 mg/ml in Methanol, Morphinan-3-ol, 6,7,8,14-tetradehydro-4,5-alpha-epoxy-6-methoxy-17-methyl-, NS00031627, C06175, MORPHINE SULFATE IMPURITY C [EP IMPURITY], Q420639, CODEINE MONOHYDRATE IMPURITY L [EP IMPURITY], MORPHINE HYDROCHLORIDE IMPURITY C [EP IMPURITY], CODEINE HYDROCHLORIDE DIHYDRATE IMPURITY L [EP IMPURITY], CODEINE PHOSPHATE HEMIHYDRATE IMPURITY L [EP IMPURITY], 6-Methoxy-17-methyl-5alpha-6,7,8,14-tetradehydro-4,5-epoxymorphinan-3-ol, 6,7,8,14-TETRADEHYDRO-4,5.ALPHA.-EPOXY-6-METHOXY-17-METHYLMORPHINAN-3-OL, (4R,7aR,12bS)-7-methoxy-3-methyl-2,3,4,7a-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-9-ol
Theoretical properties:
molecular_formula: C18H19NO3
molecular_weight: 297.3 g/mol
exact_mass: 297.13649347 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 4
rotatable_bond_count: 1
heavy_atom_count: 22
topological_polar_surface_area: 41.9 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
physical_state: Crystals
color: Crystals
melting_point: 200-201 °C
Descriptions:
pubchem: Oripavine is a morphinane alkaloid with formula C18H19NO3. It is the major metabolite of thebaine. It has a role as an opioid analgesic and a bacterial xenobiotic metabolite. It is a morphinane alkaloid, an ether, an organic hydroxy compound, an organic heteropentacyclic compound and a tertiary amino compound. It is a conjugate base of an oripavine(1+).
chebi: A morphinane alkaloid with formula C<small><sub>18</sub></small>H<small><sub>19</sub></small>NO<small><sub>3</sub></small>. It is the major metabolite of thebaine.
chembl: ORIPAVINE is a small molecule listed in the ChEMBL database but has not progressed to an approved clinical phase.
wikipedia: Oripavine is an opioid and the major metabolite of thebaine. It is the precursor to the semi-synthetic compounds etorphine and buprenorphine. Although this chemical compound has analgesic potency comparable to morphine, it is not used clinically due to severe adverse effects and a low therapeutic index. Being a precursor to a series of extremely strong opioids, oripavine is a controlled substance in some jurisdictions.