Compound: Alfaxalone
SMILES: O=C1[C@@H]2[C@@]3([C@H](C[C@H](O)CC3)CC[C@H]2[C@@H]4CC[C@@H]([C@]4(C1)C)C(=O)C)C
InChIKey: DUHUCHOQIDJXAT-OLVMNOGESA-N
Synonyms: Alfaxalone, Alphaxalone, 23930-19-0, Alphaxolone, Alfaxalona, Alfaxalonum, Phaxan, 3alpha-Hydroxy-5alpha-pregnane-11,20-dione, GR 2/234, DTXSID9022576, Alfadione, BD07M97B2A, (3R,5S,8S,9S,10S,13S,14S,17S)-17-acetyl-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-11-one, GR-2/234, alfaxolone, DTXCID702576, delta(16)-alfaxalone, Alfaxan, Alfaxan Multidose, (3R,5S,8S,9S,10S,13S,14S,17S)-17-acetyl-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,12,14,15,16,17-tetradecahydrocyclopenta(a)phenanthren-11-one, hydroxy-5 alpha-pregnane-11,20-dione, RefChem:57111, ALFAXAN MULTIDOSE IDX, N01AX05, 5alpha-Pregnan-3alpha-ol-11,20-dione, Alfaxalonum [INN-Latin], Alfaxalona [INN-Spanish], MLS000069684, MLS001076262, CHEMBL190279, Alfaxalone (INN), 3-Hydroxypregnane-11,20-dione, Alfaxalone; Alphaxalone, NCGC00023100-03, SMR000058494, (3a,5a)-3-Hydroxypregnane-11,20-dione, ALFAXALONE [INN], SR-01000000168, BRN 3217240, UNII-BD07M97B2A, 3alpha-Hydroxy-5alpha-pregnan-11,20-dion, 5alpha-alphaxalone, Alfaxalone [INN:BAN:DCF:JAN], 3-alpha-Hydroxy-5-alpha-pregnane-11,20-dione, (3-alpha,5-alpha)-3-Hydroxypregnane-11,20-dione, CAS-23930-19-0, ALFAXALONE [MI], 3.alpha.-Hydroxy-5.alpha.-pregnane-11,20-dione, ALFAXALONE [JAN], Opera_ID_1629, Prestwick0_001002, Prestwick1_001002, Prestwick2_001002, Prestwick3_001002, ALFAXALONE [MART.], ALFAXALONE [WHO-DD], BIDD:PXR0037, Lopac0_000929, Pregnane-11,20-dione, 3-hydroxy-, (3a,5a)-, SCHEMBL57756, BSPBio_001123, 4-08-00-02091 (Beilstein Handbook Reference), 5-alpha-Pregnane-11,20-dione, 3-alpha-hydroxy-, SPBio_003004, BPBio1_001237, GTPL5461, ALFAXALONE [GREEN BOOK], CHEBI:34531, Pregnane-11,20-dione, 3-hydroxy-, (3-alpha,5-alpha)-, HMS1571I05, HMS2098I05, HMS2236N05, HMS3262J20, HMS3715I05, MSK14604, Tox21_110884, Tox21_500929, BDBM50164570, AKOS024457399, Tox21_110884_1, CCG-205010, DB11371, LP00929, SDCCGSBI-0050903.P002, 5alpha-pregnane-3alpha-ol-11,20-dione, NCGC00023100-04, NCGC00023100-05, NCGC00023100-06, NCGC00023100-08, NCGC00261614-01, AB00384358, EU-0100929, NS00067930, D07282, P 5052, (3alpha,5alpha)-3-hydroxypregnane-11,20-dione, SR-01000076070, Q3611058, SR-01000000168-2, SR-01000000168-3, SR-01000076070-1, BRD-K41445866-001-03-0, BRD-K41445866-001-18-8, 5alpha-Pregnan-3alpha-ol-11,20-dione, powder, >=98% (TLC), (3beta,5alpha,8alpha,9beta,10alpha)-3-hydroxypregnane-11,20-dione, (3R,5S,8S,9S,10S,13S,14S,17S)-17-Acetyl-3-hydroxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-11-one, EY4
Theoretical properties:
molecular_formula: C21H32O3
molecular_weight: 332.5 g/mol
exact_mass: 332.23514488 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 3
rotatable_bond_count: 1
heavy_atom_count: 24
topological_polar_surface_area: 54.4 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Alphaxolone is a corticosteroid hormone.
chembl: ALFAXALONE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 2.0.
wikipedia: Alfaxalone, also known as alphaxalone or alphaxolone and sold under the brand name Alfaxan and Faxone, is a neuroactive steroid and general anesthetic which is used currently in veterinary practice as an induction agent for anesthesia and as an injectable anesthetic. The most common side effect seen in current veterinary practice is respiratory depression when Alfaxan is administered concurrently with other sedative and anesthetic drugs; when premedications are not given, veterinary patients also become agitated and hypersensitive when waking up.
Alfaxalone works as a positive allosteric modulator on GABAA receptors and, at high concentrations, as a direct agonist of the GABAA receptor. It is cleared quickly by the liver, giving it a relatively short terminal half-life and preventing it from accumulating in the body, lowering the chance of overdose.