Compound: morphine
SMILES: O1c2c(O)ccc3c2[C@@]45[C@@H]1[C@@H](O)C=C[C@H]4[C@H](N(C)CC5)C3
InChIKey: BQJCRHHNABKAKU-KBQPJGBKSA-N
Synonyms: morphine, Morphia, Morphium, Morphina, (-)-Morphine, Morphinum, Ospalivina, Morphin, Duromorph, 57-27-2, Meconium, Morphinism, Nepenthe, Dulcontin, Roxanol, Morfina, Morpho, Statex SR, Anhydrous morphine, M-Eslon, Aguettant, Dinamorf, Dimorf, Morphine anhydrous, Morphine (anhydrous), Morphine extended release, (5R,6S,9R,13S,14R)-4,5-Epoxy-N-methyl-7-morphinen-3,6-diol, IDS-NM-009, CHEBI:17303, 4,5alpha-Epoxy-17-methyl-7-morphinen-3,6alpha-diol, N02AA01, 76I7G6D29C, 7,8-Didehydro-4,5-epoxy-17-methyl-morphinan-3,6-diol, DTXSID9023336, (5alpha,6alpha)-17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol, 9H-9,9c-Iminoethanophenanthro(4,5-bcd)furan-3,5-diol, 4a,5,7a,8-tetrahydro-12-methyl-, (7R,7AS,12BS)-3-METHYL-2,3,4,4A,7,7A-HEXAHYDRO-1H-4,12-METHANO[1]BENZOFURO[3,2-E]ISOQUINOLINE-7,9-DIOL, Chloride, Morphine, (5alpha,6alpha)-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol, morphine tincture, Contin, MS, (1S,5R,13R,14S,17R)-4-methyl-12-oxa-4-azapentacyclo(9.6.1.0^(1,13).0^(5,17).0^(7,18))octadeca-7(18),8,10,15-tetraene-10,14-diol, (1S,5R,13R,14S,17R)-4-methyl-12-oxa-4-azapentacyclo(9.6.1.0^(1,13).0^(5,17).0^(7,18))octadeca-7,9,11(18),15-tetraene-10,14-diol, (1S,5R,13R,14S,17R)-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10,15-tetraene-10,14-diol, (1S,5R,13R,14S,17R)-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7,9,11(18),15-tetraene-10,14-diol, (7R,7AS,12bs)-3-methyl-2,3,4,4a,7,7a-hexahydro-1H-4,12-methano(1)benzofuro(3,2-e)isoquinoline-7,9-diol, SDZ202-250, MORPHINE BASE, RefChem:6656, Opium Tincture Deodorized, DTXCID203336, SDZ202250, SDZ 202250, SDZ202 250, SDZ 202 250, Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl-(5alpha,6alpha)-, (1S,5R,13R,14S,17R)-4-methyl-12-oxa-4-azapentacyclo(9.6.1.01,13.05,17.07,18)octadeca-7(18),8,10,15-tetraene-10,14-diol, (4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro(3,2-e)isoquinoline-7,9-diol, 200-320-2, NSC11411, l-Morphine, MS Contin, Dreamer, Hocus, Unkie, Cube juice, Hard stuff, Ms Emma, Morphin [German], Morfina [Italian], Morphina [Italian], Morphine [BAN], CCRIS 5762, HSDB 2134, CHEMBL70, Morphine Anhydrate, Morphine (BAN), RMS, Morphinan-3,6-alpha-diol, 7,8-didehydro-4,5-alpha-epoxy-17-methyl-, Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl-, (5alpha,6alpha)-, methyl[?]diol, Morphine (1.0 mg/mL in Methanol), (5alpha,6alpha)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol, Morphine (1.0mg/ml in Acetonitrile), MOI, D-(-)-Morphine, EINECS 200-320-2, UNII-76I7G6D29C, DEA No. 9300, (Morphine), Morphine polistirex, Substitol (TN), (-)-(etorphine), (-)Morphine sulfate, MORPHINE [HSDB], MORPHINE [MI], MORPHINE [VANDF], MORPHINE [MART.], Epitope ID:116646, MORPHINE [WHO-DD], SCHEMBL2997, BIDD:GT0147, GTPL1627, SCHEMBL4740781, (5.alpha.,6.alpha.)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol, SCHEMBL11684914, SCHEMBL27850914, SCHEMBL29350575, Morphine 0.1 mg/ml in Methanol, Morphine 1.0 mg/ml in Methanol, BDBM579485, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol, US11484525, Compound Morphine, Morphine (1 mg/ml in Acetonitrile), 7,8-DIDEHYDRO-4,5alpha-EPOXY-17-METHYLMORPHINAN-3,6alpha-DIOL, BDBM50000092, MORPHINE (ANHYDROUS) [VANDF], AKOS015966554, DB00295, NS00000380, C01516, D08233, Hydromorphone hydrochloride impurity, morphine-, Q81225, CODEINE MONOHYDRATE IMPURITY B [EP IMPURITY], 7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol, ETHYLMORPHINE HYDROCHLORIDE IMPURITY B [EP IMPURITY], HYDROMORPHONE HYDROCHLORIDE IMPURITY C [EP IMPURITY], CODEINE HYDROCHLORIDE DIHYDRATE IMPURITY B [EP IMPURITY], CODEINE PHOSPHATE HEMIHYDRATE IMPURITY B [EP IMPURITY], CODEINE PHOSPHATE SESQUIHYDRATE IMPURITY B [EP IMPURITY], 17-Methyl-5alpha-7,8-didehydro-4,5-epoxymorphinan-3,6alpha-diol, 7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol(morphine), DIHYDROCODEINE HYDROGEN TARTRATE IMPURITY B [EP IMPURITY], (5alpha,6beta)-17-methyl-7,8-didehydro-4,5-epoxymorphinan-3,6-diol, 3-(4-Hydroxy-phenyl)-1-propyl-piperidine-3-carboxylic acid ethyl ester, 4,5.ALPHA.-EPOXY-17-METHYL-7,8-DIDEHYDROMORPHINAN-3,6.ALPHA.-DIO, 6-tert-Butyl-3-methyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocine, APOMORPHINE HYDROCHLORIDE HEMIHYDRATE IMPURITY B [EP IMPURITY], HYDROCODONE HYDROGEN TARTRATE 2.5-HYDRATE IMPURITY A [EP IMPURITY], HYDROMORPHONE HYDROCHLORIDE IMPURITY, MORPHINE- [USP IMPURITY], (-)(5.alpha.,6.alpha.)-7,8-Didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol, MORPHINAN-3,6-DIOL, 7,8-DIDEHYDRO-4,5-EPOXY-17-METHYL, (5.ALPHA.,6.ALPHA.)-, Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5..alpha.,6.alpha.)-, (1S,5R,13R,14S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol, (morphine) 4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol, 2-{4-[2,4-diamino-6-pteridinylmethyl(methyl)amino]phenylcarboxamido}pentanedioic acid(morphine), 4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol, 4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol ; HydroChloride, 4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol ;sulphate salt(morphine), 4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol((Morphine)), 4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol(morphine sulfate), 4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol(morphine), 4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol(Morphine)(HCl), 4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol,sulfate(Morphinesulfate), 4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diolMorphine, 4-methyl-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol, 4-methyl-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol (morphine), 4-methyl-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol(Morphine), 6,11-Dimethyl-3-(3-methyl-but-2-enyl)-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol(Morphine), 9H-9,9c-Iminoethanophenanthro(4,5-bcd)furan-3,5-diol, 4alpha,5,7alpha,8-tetrahydro-12-methyl-, Morphine;4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10,15-tetraene-10,14-diol
Theoretical properties:
molecular_formula: C17H19NO3
molecular_weight: 285.34 g/mol
exact_mass: 285.13649347 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 2
hydrogen_bond_acceptor_count: 4
rotatable_bond_count: 0
heavy_atom_count: 21
topological_polar_surface_area: 52.9 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
physical_state: Prisms
color: Prisms
odor: Odorless
boiling_point: 190ºC
density: 1.32 at 20 °C/4 °C
Descriptions:
{"pubchem": "Morphine is a morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy). It has a role as a geroprotector, an opioid analgesic, a vasodilator agent, a xenobiotic, an anaesthetic, a mu-opioid receptor agonist, a plant metabolite, an environmental contaminant and a drug allergen. It is a morphinane alkaloid, an organic heteropentacyclic compound and a tertiary amino compound. It is a conjugate base of a morphine(1+). It derives from a hydride of a morphinan.", "chebi": "A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in <em>Papaver somniferum</em> (the opium poppy).", "chembl": "MORPHINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.", "wikipedia": "Morphine, formerly known as morphium, is an opiate found naturally in opium, a dark brown resin produced by drying the latex of opium poppies (Papaver somniferum). It is mainly used as an analgesic (pain medication). There are multiple methods used to administer morphine: oral; sublingual; via inhalation; injection into a muscle, injection under the skin, or injection into the spinal cord area; transdermal; intravenously; or via rectal suppository. It acts directly on the central nervous system (CNS) to induce analgesia and alter perception and emotional response to pain. Physical and psychological dependence and tolerance may develop with repeated administration. It can be taken for both acute pain and chronic pain and is frequently used for pain from myocardial infarction, kidney stones, and during labor. Its maximum effect is reached after about 20 minutes when administered intravenously and 60 minutes when administered by mouth, while the duration of its effect is 3\u20137 hours. Long-acting formulations of morphine are sold under the brand names MS Contin and Kadian, among others. Generic long-acting formulations are also available.\nCommon side effects of morphine include drowsiness, euphoria, nausea, dizziness, sweating, and constipation. Potentially serious side effects of morphine include decreased respiratory effort, vomiting, and low blood pressure. Morphine is highly addictive and prone to abuse. If one's dose is reduced after long-term use, opioid withdrawal symptoms may occur. Caution is advised for the use of morphine during pregnancy or breastfeeding, as it may affect the health of the baby.\nMorphine was first isolated in 1804 by German pharmacist Friedrich Sert\u00fcrner. This is believed to be the first isolation of a medicinal alkaloid from a plant. Merck began marketing it commercially in 1827. Morphine was more widely used after the invention of the hypodermic syringe in 1853\u20131855. Sert\u00fcrner originally named the substance morphium, after the Greek god of dreams, Morpheus, as it has a tendency to cause sleep.\nThe primary source of morphine is isolation from poppy straw of the opium poppy. In 2013, approximately 523 tons of morphine were produced. Approximately 45 tons were used directly for pain, an increase of 400% over the last twenty years. Most use for this purpose was in the developed world. About 70% of morphine is used to make other opioids such as hydromorphone, oxymorphone, and heroin. It is a Schedule II drug in the United States, Class A in the United Kingdom, and Schedule I in Canada. It is on the World Health Organization's List of Essential Medicines. In 2023, it was the 156th most commonly prescribed medication in the United States, with more than 3 million prescriptions. It is available as a generic medication."}