Compound: aceclidine
SMILES: O=C(OC1C2CCN(C1)CC2)C
InChIKey: WRJPSSPFHGNBMG-UHFFFAOYSA-N
Synonyms: aceclidine, 827-61-2, 3-Acetoxyquinuclidine, 3-Quinuclidinol acetate (ester), Aceclidina, Aceclidinum, 3-Quinuclidinol acetate, 1-Azabicyclo(2.2.2)octan-3-ol, acetate (ester), NSC-657843, NSC-758239, 0578K3ELIO, DTXSID2045658, 1-Azabicyclo(2.2.2)octan-3-ol, acetate, acetic acid quinuclidin-3-yl ester, DTXCID0025658, 1-Azabicyclo[2.2.2]octan-3-ol, acetate (ester), aceclidin, 3-quinuclidinol dl-form acetate (ester), 1-Azabicyclo[2.2.2]octan-3-ol, acetate, RefChem:914942, S01EB08, 212-574-1, Quinuclidin-3-yl acetate, 1-azabicyclo[2.2.2]octan-3-yl acetate, Glaucostat, MFCD00468105, 3-Quinuclidinol, acetate (ester), CHEMBL20835, NSC657843, NCGC00024733-02, Aceclidine [USAN:INN], Aceclidinum [INN-Latin], Aceclidina [INN-Spanish], 3-quinuclidinyl acetate, Quinuclidin-3-ylacetate, R-(-)-3-acetoxyquinuclidine, EINECS 212-574-1, AL 304, UNII-0578K3ELIO, plusmnaceclidine, racemic aceclidine, Glaucostat (TN), aceclidine,R(-), aceclidine,S(+), VIZZ, NSC 657843, Spectrum_001338, Solifenacin Impurity 56, ACECLIDINE [INN], 3-Quinuclidinol, acetate, Aceclidine (USAN/INN), Spectrum2_001235, Spectrum3_001446, Spectrum4_000421, Spectrum5_001301, ACECLIDINE [USAN], ACECLIDINE [MART.], (RS)-3-acetoxyquinuclidine, ACECLIDINE [WHO-DD], (+) 3-acetoxy quinuclidine, BSPBio_002911, KBioGR_000742, KBioSS_001818, LINZ101, (RS) 3-acetoxy quinuclidine, DivK1c_000180, SCHEMBL121393, SPBio_001110, LINZ-101, orb1705929, CHEBI:93847, GTPL14102, KBio1_000180, KBio2_001818, KBio2_004386, KBio2_006954, KBio3_002411, NINDS_000180, HMS3264B20, Pharmakon1600-01501124, CS-B0278, Tox21_110921, Aceclidine; quinuclidin-3-yl acetate, BDBM50034625, EBC-26126, NSC758239, STL430459, AKOS006281409, CCG-212926, DB13262, DS-5025, 1-Azabicyclo[2.2.2]oct-3-yl acetate, IDI1_000180, NCGC00024733-03, NCGC00024733-04, CAS-827-61-2, DA-50124, HY-32067, NCI60_020173, NCI60_020184, SY111901, 1-Azabicyclo[2.2.2]oct-3-yl acetate #, NS00006968, D02750, AB00053601_02, AB00053601_03, EN300-3463436, Acetic acid 1-aza-bicyclo[2.2.2]oct-3-yl ester, acetic acid 1-azabicyclo[2.2.2]octan-3-yl ester, F238955, L023942, Q2362603, 3-QUINUCLIDINOL DL-FORM ACETATE (ESTER) [MI], BRD-A32673558-001-01-7, BRD-A32673558-001-02-5, BRD-A32673558-003-02-1, BRD-A32673558-003-03-9, BRD-A80567352-003-01-6, BRD-A80567352-003-02-4, Acetic acid 1-aza-bicyclo[2.2.2]oct-3-yl ester(aceclidine)
Theoretical properties:
molecular_formula: C9H15NO2
molecular_weight: 169.22 g/mol
exact_mass: 169.110278721 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 3
rotatable_bond_count: 2
heavy_atom_count: 12
topological_polar_surface_area: 29.5 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Acetic acid 1-azabicyclo[2.2.2]octan-3-yl ester is a member of quinuclidines.
chembl: ACECLIDINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 3.0.
wikipedia: Aceclidine is a parasympathomimetic cholinergic drug that functions as a muscarinic acetylcholine receptor agonist. It is used in ophthalmology as a miotic agent to constrict the pupil. Historically used in Europe for the treatment of glaucoma, aceclidine received its first U.S. approval in 2025 under the brand name Vizz as a topical eye drop for the correction of presbyopia. Its mechanism of action produces pupil contraction with a relatively minimal effect on the ciliary muscle, which improves near visual acuity through a "pinhole" depth-of-field effect without inducing significant accommodative spasm.