Compound: serotonin
SMILES: Oc1cc2c([nH]cc2CCN)cc1
InChIKey: QZAYGJVTTNCVMB-UHFFFAOYSA-N
Synonyms: serotonin, 5-HYDROXYTRYPTAMINE, 50-67-9, 3-(2-Aminoethyl)-1H-indol-5-ol, Enteramine, Thrombotonin, Thrombocytin, Serotonine, 1H-Indol-5-ol, 3-(2-aminoethyl)-, Hippophaine, 3-(beta-Aminoethyl)-5-hydroxyindole, 333DO1RDJY, DTXSID8075330, CHEBI:28790, 3-(2-Aminoethyl)-1H-indol-5-o, Serotonin (Human), 5 Hydroxytryptamine, Serotonin 1543, RefChem:6493, DTXCID4040765, 200-058-9, NSC58241, 5-HT, Antemovis, Ds substance, Hippophain, 5-Hta, Antemoqua, Substance DS, Substanz DS, Tryptamine, 5-hydroxy-, 3-(2-Aminoethyl)indol-5-ol, Indol-5-ol, 3-(2-aminoethyl)-, Enteramin, 5-Hydroxy-3-(beta-aminoethyl)indole, 3-(2-Amino-ethyl)-1H-indol-5-ol, MFCD00055054, 3-(.beta.-Aminoethyl)-5-hydroxyindole, 5-Hydroxytryptamine, free base, Lisinopril Impurity 21, EINECS 200-058-9, UNII-333DO1RDJY, BRN 0143524, Serotonin base, 5-hydroxytryptamin, 3-(2-Aminoethyl)-5-hydroxyindole, 5-Hydroxytriptamine, 5-Hydroxyltryptamine, 5-hydroxy-tryptamine, 1H-Indol-5-ol,3-(2-aminoethyl)-, Enteramin; Enteramine, 5-hydroxyl tryptamine, GTPL5, SEROTONIN [MI], CHEMBL39, Prestwick0_000481, Prestwick1_000481, Prestwick2_000481, Prestwick3_000481, Lopac-H-9523, 5-Hydroxytryptamine;5-HT, Biomol-NT_000083, bmse000757, SEROTONIN [MART.], SCHEMBL1495, SEROTONIN [WHO-DD], Lopac0_000607, Oprea1_712368, BSPBio_000341, BSPBio_001112, KBioGR_000452, KBioGR_002472, KBioSS_000452, KBioSS_002479, 5-22-12-00016 (Beilstein Handbook Reference), Serotonin, analytical standard, SPBio_002262, BPBio1_000377, BPBio1_001079, orb1297148, orb3141069, SCHEMBL11339569, SCHEMBL29349412, BCBcMAP01_000198, BDBM10755, KBio2_000452, KBio2_002472, KBio2_003020, KBio2_005040, KBio2_005588, KBio2_007608, KBio3_000843, KBio3_000844, KBio3_002950, cMAP_000059, 3-(b-Aminoethyl)-5-hydroxyindole, 5-Hydroxy-3-(b-aminoethyl)indole, Bio1_000450, Bio1_000939, Bio1_001428, Bio2_000396, Bio2_000876, HMS1362H13, HMS1792H13, HMS1990H13, HMS3403H13, EBC-84080, PDSP1_001512, PDSP2_001496, STK503758, AKOS001484724, 3-(2-Aminoethyl)-1H-indol-5-ol #, CCG-204696, DB08839, FH52409, indole, 3-(2-aminoethyl)-5-hydroxy-, MSK157682-100M, SDCCGSBI-0050589.P002, 5-Hydroxy-3-(.beta.-aminoethyl)indole, IDI1_002151, SMP1_000272, 5-hydroxy tryptamine creatinine disulfate, MSK157682-1000M, NCGC00015525-01, NCGC00015525-02, NCGC00015525-03, NCGC00015525-04, NCGC00015525-05, NCGC00015525-06, NCGC00015525-07, NCGC00015525-08, NCGC00015525-09, NCGC00015525-18, NCGC00015525-19, NCGC00142449-01, NCGC00142449-02, NCGC00142449-03, NCGC00142449-04, NCGC00142449-05, AS-75772, CAS-153-98-0, Serotonin Solution in Methanol, 100ug/mL, DB-051820, Serotonin Solution in Methanol, 1000ug/mL, NS00007188, 14C-5-hydroxy tryptamine creatinine disulfate, C00780, EN300-120141, G77704, H-8000, L000078, Q167934, Serotonin base; 3-(2-Aminoethyl)-5-hydroxyindole, BRD-K38580127-003-15-4, BRD-K38580127-003-16-2, BRD-K38580127-003-17-0, 6F7FD5B4-A558-45F0-A20A-2D068A3EFE6A, 2-imino-1-methylimidazolidin-4-one; 3-(2-aminoethyl)-1H-indol-5-ol; bis(sulfuric acid), 1094000-36-8
Theoretical properties:
molecular_formula: C10H12N2O
molecular_weight: 176.21 g/mol
exact_mass: 176.094963011 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 3
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 2
heavy_atom_count: 13
topological_polar_surface_area: 62 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
solubility: 25.5 mg/mL
Descriptions:
{"pubchem": "Serotonin is a primary amino compound that is the 5-hydroxy derivative of tryptamine. It has a role as a neurotransmitter, a mouse metabolite and a human metabolite. It is a monoamine molecular messenger, a member of tryptamines, a member of phenols, a primary amino compound and a member of hydroxyindoles. It is functionally related to a tryptamine. It is a conjugate base of a serotonin(1+).", "chebi": "A primary amino compound that is the 5-hydroxy derivative of tryptamine.", "chembl": "SEROTONIN is a small molecule listed in the ChEMBL database and has reached clinical trial phase 3.0.", "wikipedia": "Serotonin (), also known as 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter with a wide range of functions in both the central nervous system (CNS) and also peripheral tissues. It is involved in mood, cognition, reward, learning, memory, and physiological processes such as vomiting and vasoconstriction. In the CNS, serotonin regulates mood, appetite, and sleep.\nMost of the body's serotonin\u2014about 90%\u2014is synthesized in the gastrointestinal tract by enterochromaffin cells, where it regulates intestinal movements. It is also produced in smaller amounts in the brainstem's raphe nuclei, the skin's Merkel cells, pulmonary neuroendocrine cells, and taste receptor cells of the tongue. Once secreted, serotonin is taken up by platelets in the blood, which release it during clotting to promote vasoconstriction and platelet aggregation. Around 8% of the body's serotonin is stored in platelets, and 1\u20132% is found in the CNS.\nSerotonin acts as both a vasoconstrictor and vasodilator depending on concentration and context, influencing hemostasis and blood pressure regulation. It plays a role in stimulating myenteric neurons and enhancing gastrointestinal motility through uptake and release cycles in platelets and surrounding tissue. Biochemically, serotonin is an indoleamine synthesized from tryptophan and metabolized primarily in the liver to 5-hydroxyindoleacetic acid (5-HIAA).\nSerotonin is targeted by several classes of antidepressants, including selective serotonin reuptake inhibitors (SSRIs) and serotonin\u2013norepinephrine reuptake inhibitors (SNRIs), which block reabsorption in the synapse to elevate its levels. It is found in nearly all bilateral animals, including insects, spiders and worms, and also occurs in fungi and plants. In plants and insect venom, it serves a defensive function by inducing pain. Serotonin released by pathogenic amoebae may cause diarrhea in the human gut, while its presence in seeds and fruits is thought to stimulate digestion and facilitate seed dispersal.\n\n"}