Compound: Magnolol
SMILES: Oc1c(-c2c(O)ccc(c2)CC=C)cc(CC=C)cc1
InChIKey: VVOAZFWZEDHOOU-UHFFFAOYSA-N
Synonyms: Magnolol, 528-43-8, 5,5'-Diallyl-2,2'-dihydroxybiphenyl, Dehydrodichavicol, 2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol, 4-allyl-2-(5-allyl-2-hydroxy-phenyl)phenol, 001E35HGVF, DTXSID0044076, NSC-293099, FEMA NO. 4559, (1,1'-Biphenyl)-2,2'-diol, 5,5'-di-2-propenyl-, [1,1'-Biphenyl]-2,2'-diol, 5,5'-di-2-propenyl-, RefChem:155298, DTXCID8024076, 610-903-7, 5,5'-Diallyl-[1,1'-biphenyl]-2,2'-diol, 5,5'-Diallyl-2,2'-biphenyldiol, 2,2'-Bichavicol, MFCD00016658, NSC 293099, MLS001048917, 5,5'-Diallylbiphenyl-2,2'-diol, SMR000387108, 2-[2-hydroxy-5-(prop-2-en-1-yl)phenyl]-4-(prop-2-en-1-yl)phenol, 5,5'-di(prop-2-en-1-yl)biphenyl-2,2'-diol, 2'-Bichavicol, SR-01000758206, UNII-001E35HGVF, HSDB 7686, Magnolol CRS, 5,5'-Di-2-propen-1-yl-[1,1'-biphenyl]-2,2'-diol; 2,2'-Bichavicol; 5,5'-Diallyl-2,2'-biphenyldiol; Magnolol; NSC 293099, Magnolol (Standard), MAGNOLOL [HSDB], MAGNOLOL [MI], UPCMLD-DP037, cid_72300, SCHEMBL132477, REGID_for_CID_72300, CHEBI:6643, CHEMBL180920, orb1304635, orb3139961, SCHEMBL29538482, SCHEMBL29649179, UPCMLD-DP037:001, BDBM78304, GTPL14021, HY-N0163R, 5,5'-bis(prop-2-en-1-yl)-[1,1'-biphenyl]-2,2'-diol, WLZ4738, HMS2269N09, HMS3651O18, HMS5080J10, HY-N0163, AC-931, BBL027818, EBC-11089, NSC293099, s2321, STK801955, AKOS005266409, CCG-208588, CS-5021, DS-1284, FM09710, SMP2_000086, Magnolol, >=95% (HPLC), from plant, NCGC00161609-01, NCGC00161609-02, SY016075, D3971, NS00018055, SW219728-1, 2,2'-DIHYDROXY-5,5'-DIALLYLBIPHENYL, 5,5`-Diallyl-[1,1`-biphenyl]-2,2`-diol, EN300-7368364, F079442, 5,5'-Di-2-propenyl-[1,1'-biphenyl]-2,2'-diol, Q6732002, SR-01000758206-3, SR-01000758206-4, BRD-K26168087-001-01-4, BRD-K26168087-001-09-7, Magnolol, European Pharmacopoeia (EP) Reference Standard, Z1741977128, [1,1'-Biphenyl]-2,2'-diol, 5,5'-di-2-propen-1-yl-, 2-(2-oxidanyl-5-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol, 5,5'-Di(prop-2-en-1-yl)[1,1'-biphenyl]-2,2'-diol, 5,5'-DI-2-PROPEN-1-YL-(1,1'-BIPHENYL)-2,2'-DIOL, 5,5 inverted exclamation mark -Diallyl-2,2 inverted exclamation mark -biphenyldiol
Theoretical properties:
molecular_formula: C18H18O2
molecular_weight: 266.3 g/mol
exact_mass: 266.130679813 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 2
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 5
heavy_atom_count: 20
topological_polar_surface_area: 40.5 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
melting_point: 101.5-102 °C
solubility: Slightly soluble in water; soluble in DMSO
Descriptions:
pubchem: Magnolol is a member of biphenyls.
chembl: MAGNOLOL is a small molecule listed in the ChEMBL database but has not progressed to an approved clinical phase.
wikipedia: Magnolol is an organic compound that is classified as lignan. It is a bioactive compound found in the bark of the Houpu magnolia (Magnolia officinalis) and in M. grandiflora.
Magnolol is a compound that acts on GABAA receptors and functions as an allosteric modulator. It has antifungal properties and demonstrates anti-periodontal disease effects in animal models. In cell cultures, magnolol stimulates osteoblasts and inhibits osteoclasts, indicating potential for anti-osteoporosis treatment. It also binds in a dimeric form to PPARγ, acting as an agonist of this nuclear receptor. Additionally, magnolol may interact with cannabinoid receptors, acting as a partial agonist of CB2 receptors with lower affinity for CB1 receptors.