Compound: glycine
SMILES: O=C(O)CN
InChIKey: DHMQDGOQFOQNFH-UHFFFAOYSA-N
Synonyms: glycine, 56-40-6, 2-Aminoacetic acid, aminoacetic acid, Aminoethanoic acid, Glycocoll, Glycolixir, Glicoamin, Glycosthene, Aciport, Padil, Hampshire glycine, Amitone, Leimzucker, Acetic acid, amino-, Aminoazijnzuur, Sucre de gelatine, Glicina, GLY (IUPAC abbrev), Glycinum, Glyzin, FEMA No. 3287, Acido aminoacetico, Acide aminoacetique, Acidum aminoaceticum, Glykokoll, Aminoessigsaeure, Hgly, GLYCINE 1.5% IN PLASTIC CONTAINER, H2N-CH2-COOH, aminoacetate, NSC-25936, TE7660XO1C, AMINOACETIC ACID 1.5% IN PLASTIC CONTAINER, DTXSID9020667, NSC25936, DTXCID90667, CHEBI:15428, Acid, Aminoacetic, Copper Salt Glycine, Calcium Salt Glycine, Monosodium Salt Glycine, RefChem:6440, Salt Glycine, Monosodium, Treating Gingivitis Toothpaste, Repair Cracked Teeth Toothpaste, CAREDO Treating Gingivitis Toothpastes, CAREDO Repair Cracked Teeth Toothpastes, CAREDO Treating Gingivitis Toothpastes 100g, CAREDO Repair Cracked Teeth Toothpastes 100g, 200-272-2, 654-407-9, 2-azaniumylacetate, H-Gly-OH, L-Glycine, Glycine, non-medical, Gyn-hydralin, Corilin, Glycine [INN], Glycine, peptides, Glycinum [INN-Latin], Glicina [INN-Spanish], gly, Acide aminoacetique [INN-French], Acido aminoacetico [INN-Spanish], Acidum aminoaceticum [INN-Latin], 25718-94-9, MFCD00008131, CCRIS 5915, HSDB 495, AI3-04085, amino-Acetic acid, NSC 25936, [14C]glycine, CHEMBL773, Glycine iron sulphate (1:1), Athenon, 2-aminoacetate, NCGC00024503-01, Glycine, free base, M03001, CAS-56-40-6, Glycine, labeled with carbon-14, Glycine [USP:INN], EINECS 200-272-2, UNII-TE7660XO1C, Aminoethanoate, 18875-39-3, amino-Acetate, 2-aminoaceticacid, Glycine CRS, [3H]glycine, Glycine USP grade, Glycine (Standard), Glycine - EP, H-Gly, L-Gly, Gly-CO, Gly-OH, [14C]-glycine, Corilin (Salt/Mix), BLOTTING BUFFER, Tocris-0219, Glycine (H-Gly-OH), GLYCINE [VANDF], NH2CH2COOH, GLYCINE [FHFI], GLYCINE [HSDB], Glycine, technical grade, GLYCINE [FCC], GLYCINE [JAN], GLYCINE [II], GLYCINE [MI], GLYCINE [MART.], Glycine (JP18/USP), Glycine, 99%, FCC, GLYCINE [USP-RS], GLYCINE [WHO-DD], Biomol-NT_000195, bmse000089, bmse000977, WLN: Z1VQ, EC 200-272-2, SCHEMBL6163, Gly-253, SCHEMBL62594, GLYCINE [GREEN BOOK], GTPL727, AB-131/40217813, GLYCINE [ORANGE BOOK], SCHEMBL208601, SCHEMBL887085, Glycine, Electrophoresis Grade, GLYCINE [EP MONOGRAPH], BPBio1_001222, GTPL4084, GTPL4635, orb1304737, SCHEMBL1770702, SCHEMBL3928487, SCHEMBL5201284, SCHEMBL9866384, GLYCINE [USP MONOGRAPH], BDBM18133, HY-Y0966R, Racecadotril Impurity Q; Glycine, AZD4282, MSK1408, Glycine, >=99.0% (NT), Glycine, 98.5-101.5%, Pharmakon1600-01300021, Glycine 1000 microg/mL in Water, CS-B1641, EAA89676, HY-Y0966, 1-aminomethyl-2-hydroxymethylbenzene, Glycine, ACS reagent, >=98.5%, Tox21_113575, EBC-00522, Glycine, 99%, natural, FCC, FG, HB0299, NSC760120, s4821, STL194276, Glycine, purum, >=98.5% (NT), Glycine, tested according to Ph.Eur., AKOS000119626, Glycine, for electrophoresis, >=99%, Tox21_113575_1, CCG-266010, DB00145, FG02717, FG71510, NSC-760120, Glycine - Absolute carbon isotope ratio, Glycine, BioUltra, >=99.0% (NT), Glycine, BioXtra, >=99% (titration), SERINE IMPURITY B [EP IMPURITY], Glycine, SAJ special grade, >=99.0%, NCGC00024503-02, NCGC00024503-03, BP-31024, FG175750, Glycine, Vetec(TM) reagent grade, 98%, DB-029870, G0099, G0317, Glycine, ReagentPlus(R), >=99% (HPLC), NS00001575, EN300-19731, C00037, C22407, D00011, D70890, L001246, Q620730, SR-01000597729, C-Terminal [mycofactocin precursor peptide]-glycine, Glycine, certified reference material, TraceCERT(R), SR-01000597729-1, BRD-K72369578-001-04-1, Q27115084, B72BA06C-60E9-4A83-A24A-A2D7F465BB65, F2191-0197, Glycine, European Pharmacopoeia (EP) Reference Standard, Z955123660, Glycine, BioUltra, for molecular biology, >=99.0% (NT), Glycine, from non-animal source, suitable for cell culture, InChI=1/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5, Glycine, United States Pharmacopeia (USP) Reference Standard, Glycine, Pharmaceutical Secondary Standard; Certified Reference Material, Glycine, analytical standard, for nitrogen determination according to Kjeldahl method, Glycine, from non-animal source, meets EP, JP, USP testing specifications, suitable for cell culture, >=98.5%, Glycine, meets analytical specification of Ph. Eur., BP, USP, 99-101% (based on anhydrous substance)
Theoretical properties:
molecular_formula: C2H5NO2
molecular_weight: 75.07 g/mol
exact_mass: 75.032028402 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 2
hydrogen_bond_acceptor_count: 3
rotatable_bond_count: 1
heavy_atom_count: 5
topological_polar_surface_area: 63.3 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
physical_state: White crystals
color: White crystals
odor: Odorless
melting_point: 451 °F (NTP, 1992)
density: 1.1607 (NTP, 1992) - Denser than water; will sink
solubility: greater than or equal to 100 mg/mL at 64 °F (NTP, 1992)
vapor_pressure: 0.00000013 [mmHg]
Descriptions:
{"pubchem": "Glycine is the simplest (and the only achiral) proteinogenic amino acid, with a hydrogen atom as its side chain. It has a role as a neurotransmitter, a micronutrient, a nutraceutical, a hepatoprotective agent, an EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor, a NMDA receptor agonist and a fundamental metabolite. It is a serine family amino acid, an alpha-amino acid and a proteinogenic amino acid. It is a conjugate base of a glycinium. It is a conjugate acid of a glycinate. It is a tautomer of a glycine zwitterion.", "chebi": "The simplest (and the only achiral) proteinogenic amino acid, with a hydrogen atom as its side chain.", "chembl": "GLYCINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.", "wikipedia": "Glycine (symbol Gly or G;  ) is an organic compound with the formula C2H5NO2, and is the simplest stable amino acid, distinguished by having a single hydrogen atom as its side chain. As one of the 20 proteinogenic amino acids, glycine is a fundamental building block of proteins in all life and is encoded by all codons starting with GG (GGU, GGC, GGA, and GGG). Because of its minimal side chain, it is the only common amino acid that is not chiral, meaning it is superimposable on its mirror image.\nIn the body, glycine plays several crucial roles. Its small and flexible structure is vital for the formation of certain protein structures, most notably in collagen, where glycine makes up about 35% of the amino acid content and enables the tight coiling of the collagen triple helix. Glycine disrupts the formation of alpha-helices in secondary protein structure, in favor instead of random coils. Beyond its structural role, glycine functions as an inhibitory neurotransmitter in the central nervous system, particularly in the spinal cord and brainstem, where it helps regulate motor and sensory signals. Disruption of glycine signaling can lead to severe neurological disorders and motor dysfunction; for example, the tetanus toxin causes spastic paralysis by blocking glycine release. It also serves as a key precursor for the synthesis of other important biomolecules, including the porphyrins that form heme in blood and the purines used to build DNA and RNA.\nGlycine is a white, sweet-tasting crystalline solid, leading to its name from Greek word glykys (Greek: \u03b3\u03bb\u03c5\u03ba\u03cd\u03c2) or \"sweet\". While the body can synthesize it, it is also obtained from the diet and produced industrially by chemical synthesis for use as a food additive, a nutritional supplement, and an intermediate in the manufacture of products such as the herbicide glyphosate. Glycine can fit into hydrophobic environments due to its minimal side chain.\n\n"}