Compound: Encainide
SMILES: O=C(Nc1c(cccc1)CCC2N(CCCC2)C)c3ccc(OC)cc3
InChIKey: PJWPNDMDCLXCOM-UHFFFAOYSA-N
Synonyms: Encainide, 66778-36-7, Encainida, Encainidum, 4-Methoxy-N-(2-(2-(1-methylpiperidin-2-yl)ethyl)phenyl)benzamide, MJ 9067, 4-methoxy-N-{2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl}benzamide, SY3J0147NB, (+-)-4-Methoxy-N-(2-(2-(1-methyl-2-piperidinyl)ethyl)phenyl)benzamide, 4-methoxy-N-[2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl]benzamide, BENZAMIDE, 4-METHOXY-N-(2-(2-(1-METHYL-2-PIPERIDINYL)ETHYL)PHENYL)-, (+-)-, CHEBI:4788, DTXSID0022983, (+-)-2'-[2-(1-methyl-2-piperidyl)ethyl]-p-anisanilide, 4-methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide, 4-Methoxy-N-{2-[2-(1-methyl-piperidin-2-yl)-ethyl]-phenyl}-benzamide, (+-)-2'-(2-(1-Methyl-2-piperidyl)ethyl)-P-anisanilide, 4-Methoxy-2'-(2-(1-methyl-2-piperidyl)ethyl)benzanilide, 4-Methoxy-N-(2-(2-(1-methyl-piperidin-2-yl)-ethyl)-phenyl)-benzamide, RefChem:136750, DTXCID602983, C01BC08, 973-270-9, 37612-13-8, Enkaid, Encainide [French], Encainidum [Latin], Encainida [Spanish], Encainide (INN), Benzamide, 4-methoxy-N-[2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl]-, C22H28N2O2, ENCAINIDE [INN], Encainide [INN:BAN], NCGC00185765-01, BRN 0497572, (+/-)-2'-[2-(1-methyl-2-piperidyl)ethyl]-p-anisanilide, UNII-SY3J0147NB, (+/-)-2'-(2-(1-METHYL-2-PIPERIDYL)ETHYL)-P-ANISANILIDE, BENZAMIDE, 4-METHOXY-N-(2-(2-(1-METHYL-2-PIPERIDINYL)ETHYL)PHENYL)-, Benzamide,4-methoxy-N-[2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl]-, ENCAINIDE [MI], ENCAINIDE [VANDF], ENCAINIDE [WHO-DD], SCHEMBL94346, 5-22-09-00511 (Beilstein Handbook Reference), CHEMBL315838, RCA77836, EBC-26698, EX-A13843, AKOS016014083, DB01228, NCGC00185765-02, DA-03773, HY-130335, CS-0107353, C06978, D07894, G12679, EN300-19765972, Q514534, (+/-)-4-methoxy-N-(2-(2-(1-methyl-2-piperidinyl)ethyl)phenyl)benzamide, 4-Methoxy-N-(2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl)benzamide #, (.+/-.)-4-Methoxy-N-[2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl]benzamide
Theoretical properties:
molecular_formula: C22H28N2O2
molecular_weight: 352.5 g/mol
exact_mass: 352.215078140 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 1
hydrogen_bond_acceptor_count: 3
rotatable_bond_count: 6
heavy_atom_count: 26
topological_polar_surface_area: 41.6 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
solubility: 4.01e-03 g/L
Descriptions:
pubchem: Encainide is 4-Methoxy-N-phenylbenzamide in which the hydrogen at the 2 position of the phenyl group is substituted by a 2-(1-methylpiperidin-2-yl)ethyl group. A class Ic antiarrhythmic, the hydrochloride was used for the treatment of severe or life-threatening ventricular arrhythmias, but it was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack and was withdrawn from the market. It has a role as an anti-arrhythmia drug and a sodium channel blocker. It is a member of benzamides and a member of piperidines.
chebi: 4-Methoxy-<em>N</em>-phenylbenzamide in which the hydrogen at the 2 position of the phenyl group is substituted by a 2-(1-methylpiperidin-2-yl)ethyl group. A class Ic antiarrhythmic, the hydrochloride was used for the treatment of severe or life-threatening ventricular arrhythmias, but it was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack and was withdrawn from the market.
chembl: ENCAINIDE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Encainide (trade name Enkaid) is a class Ic antiarrhythmic agent. It is no longer used because of its frequent proarrhythmic side effects.