Compound: 5-Methyluridine
SMILES: O=c1n(cc(C)c([nH]1)=O)[C@@H]2O[C@H](CO)[C@H]([C@H]2O)O
InChIKey: DWRXFEITVBNRMK-JXOAFFINSA-N
Synonyms: 5-Methyluridine, 1463-10-1, Ribothymidine, Thymine riboside, Ribosylthymine, ribosylthymidine, 1-(beta-D-ribofuranosyl)thymine, CHEBI:45996, ZS1409014A, DTXSID20163348, 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione, 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione, 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione, 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-5-methylpyrimidine-2,4-dione, RefChem:898086, DTXCID9085839, 215-973-9, Uridine, 5-methyl-, 5-Methyl Uridine, Thymine ribofuranoside, MFCD00006535, beta-D-Ribofuranoside, 5-methyl-Uridine, 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione, 1-((2R,3R,4S,5R)-TETRAHYDRO-3,4-DIHYDROXY-5-(HYDROXYMETHYL)FURAN-2-YL)-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE, L-5-Methyluridine, 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione, 1-[(4S,2R,3R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,3-dihydropyrimidine-2,4-dione, Thymine ribonucleoside, 5MU-5MU-5MU, UNII-ZS1409014A, 38T, 5-methyl-d-uridine, EINECS 215-973-9, beta-delta-Ribofuranoside, 5-Methyluridine, 97%, bmse000759, Epitope ID:141497, Epitope ID:227709, 1-b-D-Ribofuranosylthymine, SCHEMBL29298, b-D-Ribofuranoside thymine-1, .beta.-D-Ribofuranosylthymine, THYMINE RIBOSIDE [MI], 1-(?-D-ribofuranosyl)thymine, CHEMBL106175, orb1301925, SCHEMBL5888560, 1-.beta.-D-Ribofuranosylthymine, CHEBI:30821, 1-beta-delta-Ribofuranosylthymine, MSK6918, THYMINE RIBOSIDE, (-)-, beta-delta-Ribofuranoside thymine-1, .beta.-D-Ribofuranoside, thymine-1, s6156, STL507242, thymine-1 beta-D-Ribofuranosylthymine, AKOS015896830, AC-8172, CS-W010160, HY-W009444, NM04922, thymine-1 beta-delta-Ribofuranosylthymine, BP-58644, DS-18476, PD099507, SY020526, DB-030334, DB-306748, M1405, NS00024786, EN300-2009864, F212233, Q425078, Z3037473449, 5-methyl-1-beta-D-ribofuranosyl-2,4(1H,3H)-Pyrimidinedione, PYRIMIDINEDIONE, 5-METHYL-1-.BETA.-D-RIBOFURANOSYL-, 2,4(1H,3H)-Pyrimidinedione, 5-methyl-1-.beta.-D-ribofuranosyl-, 5-methyl-1-beta-delta-ribofuranosyl-2,4(1H,3H)-Pyrimidinedione, 1-.BETA.-D-RIBOFURANOSYLTHYMINE 2,4(1H,3H)-PYRIMIDINEDIONE, 5-METHYL-1-.BETA.-D-RIBOFURANOSYL-
Theoretical properties:
molecular_formula: C10H14N2O6
molecular_weight: 258.23 g/mol
exact_mass: 258.08518617 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 4
hydrogen_bond_acceptor_count: 6
rotatable_bond_count: 2
heavy_atom_count: 18
topological_polar_surface_area: 119 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
melting_point: 183 - 187 °C
Descriptions:
pubchem: Ribothymidine is a methyluridine having a single methyl substituent at the 5-position on the uracil ring. It has a role as an antigen, an Escherichia coli metabolite and a human metabolite.
chebi: A methyluridine having a single methyl substituent at the 5-position on the uracil ring.
chembl: Unnamed Compound is a small molecule listed in the ChEMBL database but has not progressed to an approved clinical phase.
wikipedia: The chemical compound 5-methyluridine (symbol m5U), also called ribothymidine (rT), is a pyrimidine nucleoside. It is the ribonucleoside counterpart to the deoxyribonucleoside thymidine, which lacks a hydroxyl group at the 2' position.  5-Methyluridine contains a thymine base joined to a ribose pentose sugar. It is a white solid.
m5U is one of the most common modifications made to cellular RNA. It almost universally occurs in position 54 (part of the T arm) of eukaryotic and bacterial tRNA, serving to stabilize the molecule. The same "T-loop" motif occurs in many other forms of noncoding RNA such as tmRNA and rRNA. Loss of the tRNA modification does not usually produce a different, less fit, phenotype.