Compound: Alcaftadine
SMILES: O=Cc1n2c(C(c3ccccc3CC2)=C4CCN(C)CC4)nc1
InChIKey: MWTBKTRZPHJQLH-UHFFFAOYSA-N
Synonyms: Alcaftadine, 147084-10-4, Lastacaft, alcaftadina, R-89674, alcaftadinum, R89674, R 89674, 7Z8O94ECSX, CHEBI:71023, DTXSID80598455, 11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine-3-carbaldehyde, 5H-IMIDAZO(2,1-B)(3)BENZAZEPINE-3-CARBOXALDEHYDE, 6,11-DIHYDRO-11-(1-METHYL-4-PIPERIDINYLIDENE)-, 11-(1-methylpiperidin-4-ylidene)-5,6-dihydroimidazo(2,3-b)(3)benzazepine-3-carbaldehyde, 11-(1-methylpiperidin-4-ylidene)-5,6-dihydroimidazo[2,3-b][3]benzazepine-3-carbaldehyde, 11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-imidazo(2,1-b)(3)benzazepine-3-carbaldehyde, 2-(1-methylpiperidin-4-ylidene)-4,7-diazatricyclo(8.4.0.0^(3,7))tetradeca-1(14),3,5,10,12-pentaene-6-carbaldehyde, 2-(1-methylpiperidin-4-ylidene)-4,7-diazatricyclo[8.4.0.0^{3,7}]tetradeca-1(14),3,5,10,12-pentaene-6-carbaldehyde, 5H-Imidazo[2,1-b][3]benzazepine-3-carboxaldehyde, 6,11-dihydro-11-(1-methyl-4-piperidinylidene)-, RefChem:57993, DTXCID70549214, S01GX11, Alcaftadine-d3, MFCD09954106, 1794775-80-6, 11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepine-3-carbaldehyde, 11-(1-methylpiperidin-4-ylidene)-5,6-dihydroimidazo[2,1-b][3]benzazepine-3-carbaldehyde, Lastacaft (TN), Alcaftadine [USAN:INN], UNII-7Z8O94ECSX, Alcaftadine (Standard), ALCAFTADINE [INN], ALCAFTADINE [JAN], ALCAFTADINE [USAN], ALCAFTADINE [VANDF], ALCAFTADINE [MART.], ALCAFTADINE [WHO-DD], Alcaftadine (JAN/USAN/INN), GTPL7587, orb1305348, SCHEMBL1602418, CHEMBL1201747, SCHEMBL29378093, Alcaftadine, >=98% (HPLC), ALCAFTADINE [ORANGE BOOK], MWTBKTRZPHJQLH-UHFFFAOYSA-N, GLXC-05049, HMS3885B12, HMS5083E04, EBC-26562, HY-17039R, s4625, AKOS025402002, CCG-267551, DB06766, 11-(1-methyl-4-piperidylidene)-5,6-dihydroimidazo[2,1-b][3]benzazepine-3-carbaldehyde, NCGC00390732-04, 2-(1-Methylpiperidin-4-ylidene)-4,7-diazatricyclo[8.4.0.0(3,7)]tetradeca- 1(14),3,5,10,12-pentaene-6-carbaldehyde, AC-28019, AS-56303, DA-60880, HY-17039, DB-063693, A3237, NS00070524, D06552, EN300-18738255, Q4712900, BRD-K55991142-001-01-6, 11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-imidazolo[2,1-b][3]benzazepine-3-carbaldehyde, 2-(1-methylpiperidin-4-ylidene)-4,7-diazatricyclo[8.4.0.0,3,7]tetradeca-1(10),3,5,11,13-pentaene-6-carbaldehyde, 4-(1-METHYL-PIPERIDIN-4-YLIDENE)-9,10-DIHYDRO-4H-3,10A-DIAZA-BENZO(F)AZULENE-1-CARBALDEHYDE, 5H-Imidazo(2,1-b)(3)benzazepine-3-carboxaldehyde, 6,11-dihydro-11-(1-methyl-4- piperidinylidene)-
Theoretical properties:
molecular_formula: C19H21N3O
molecular_weight: 307.4 g/mol
exact_mass: 307.168462302 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 3
rotatable_bond_count: 1
heavy_atom_count: 23
topological_polar_surface_area: 38.1 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
solubility: slightly solubility
Descriptions:
pubchem: Alcaftadine is an imidazobenzazepine that is 6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine substituted at position 3 by a formyl group and at position 11 by a 1-methylpiperidin-4-ylidene group. An antihistamine used for treatment of allergic conjunctivitis. It has a role as a H1-receptor antagonist and an anti-allergic agent. It is an aldehyde, a member of piperidines, a tertiary amino compound and an imidazobenzazepine.
chebi: An imidazobenzazepine that is 6,11-dihydro-5<em>H</em>-imidazo[2,1-<em>b</em>][3]benzazepine substituted at position 3 by a formyl group and at position 11 by a 1-methylpiperidin-4-ylidene group. An antihistamine used for treatment of allergic conjunctivitis.
chembl: ALCAFTADINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Alcaftadine, sold under the brand name Lastacaft, is an antihistamine used to help prevent itching of the eyes. It is an H1 histamine receptor antagonist. It is given as an drops in the eye.
It was approved for medical use in the United States in July 2010. It is available as a generic medication and as an over-the-counter medication.