Compound: piperazine
SMILES: N1CCNCC1
InChIKey: GLUUGHFHXGJENI-UHFFFAOYSA-N
Synonyms: piperazine, 110-85-0, Diethylenediamine, 1,4-Diazacyclohexane, Hexahydropyrazine, Piperazidine, Piperazin, Antiren, Diethyleneimine, Dispermine, Lumbrical, Pipersol, Eraverm, 1,4-Piperazine, Wurmirazin, Uvilon, Piperazine, anhydrous, Worm-A-Ton, 1,4-Diethylenediamine, Pyrazine hexahydride, Hexahydro-1,4-diazine, Pyrazine, hexahydro-, Piperazine (USP), NSC-474, 1RTM4PAL0V, Piperazine [USP], DTXSID1021164, FEMA NO. 4250, CHEBI:28568, P02CB01, DTXCID701164, 1,4 Diazacyclohexane, Vermizine, Ascalix, Ectodyne, Expelix, Wormex, Ins umuline rapide, 1,4 Piperazine, RefChem:6143, piperazine phosphate (1:1), 203-808-3, Vermex, Asca-Trol No. 3, Vermizine (TN), MFCD00005953, NSC 474, Trimetazidine EP Impurity G, NSC474, Piperazine anhydrous, Eraverm (VAN), Piperazin [German], NCGC00094762-03, Upixon, Piperazin [Germany], 31977-51-2, CAS-110-85-0, PZE, CCRIS 5950, HSDB 1093, EINECS 203-808-3, UNII-1RTM4PAL0V, UN2579, BRN 0102555, piperizine, piperzine, piprazine, exahydropyrazine, Piperazine-, 7-piperazine, 4-diazacyclohexane, Piperazine,anhydrous, Piperazine, 99%, Tasnon (Salt/Mix), PIPERAZINUM, Exelmin (Salt/Mix), Vermidol (Salt/Mix), Piperazine - anhydrous, Vermizine (Salt/Mix), Spectrum_001113, PIPERAZINE [II], PIPERAZINE [MI], Spectrum5_001817, PIPERAZINE [FHFI], PIPERAZINE [HSDB], SCHEMBL238, WLN: T6M DMTJ, PIPERAZINE [VANDF], PIPERAZINUM [HPUS], Epitope ID:768767, EC 203-808-3, PIPERAZINE [MART.], SCHEMBL1640, SCHEMBL8372, Piperazine, p.a., 98%, CHEMBL1412, NCIOpen2_000984, NCIOpen2_000988, NCIOpen2_001024, NCIOpen2_001031, NCIOpen2_001033, NCIOpen2_001071, NCIOpen2_001073, NCIOpen2_001111, NCIOpen2_001151, NCIOpen2_001231, NCIOpen2_001262, NCIOpen2_001269, NCIOpen2_004830, NCIOpen2_004834, NCIOpen2_004862, NCIOpen2_004874, NCIOpen2_004904, NCIOpen2_004910, NCIOpen2_004914, NCIOpen2_004942, NCIOpen2_004952, NCIOpen2_004954, NCIOpen2_004982, NCIOpen2_004992, NCIOpen2_004994, NCIOpen2_005022, NCIOpen2_005032, NCIOpen2_005034, NCIOpen2_005062, NCIOpen2_005072, NCIOpen2_005102, NCIOpen2_005108, NCIOpen2_005145, NCIOpen2_005182, NCIOpen2_005185, NCIOpen2_005187, NCIOpen2_005200, NCIOpen2_005575, NCIOpen2_005980, NCIOpen2_009422, PIPERAZINE [USP-RS], PIPERAZINE [WHO-DD], SCHEMBL77543, KBioSS_001593, 5-23-01-00030 (Beilstein Handbook Reference), BIDD:GT0273, DivK1c_000038, SCHEMBL215254, SCHEMBL524620, SCHEMBL524861, SCHEMBL908308, SPECTRUM1500490, Piperazine, analytical standard, orb1182253, orb2893579, SCHEMBL1663725, SCHEMBL6239923, SCHEMBL6575336, SCHEMBL8010246, PIPERAZINE [GREEN BOOK], HMS500B20, KBio1_000038, KBio2_001593, KBio2_004161, KBio2_006729, MSK7186, NINDS_000038, HMS1920H20, HMS2092A03, HMS3885L08, Pharmakon1600-01500490, PIPERAZINE [USP MONOGRAPH], HY-B0912, Piperazine, ReagentPlus(R), 99%, STR00051, Tox21_113564, Tox21_202242, Tox21_300104, EBC-03034, MSK7186-100M, NSC757283, s4574, STL169348, Piperazine [UN2579]  [Corrosive], AKOS000269028, MSK7186-1000M, CCG-212753, CS-4381, DB00592, FP31694, LF-0561, NSC-757283, UN 2579, IDI1_000038, NCGC00094762-01, NCGC00094762-02, NCGC00094762-04, NCGC00094762-05, NCGC00094762-08, NCGC00254077-01, NCGC00259791-01, Piperazine, anhydrous, >=99.0% (T), BP-31252, SBI-0051485.P003, Piperazine Solution in Methanol, 100ug/mL, NS00008207, P0446, P0447, Piperazine Solution in Methanol, 1000ug/mL, EN300-33920, C07973, D00807, AB00052073_03, 1,4-Diazacyclohexane; 1,4-Piperazine; Antiren;, F097595, Piperazine, BioUltra, anhydrous, >=99.0% (T), Q409292, SR-05000001700, SR-05000001700-1, BRD-K13249881-001-02-3, F0001-0226, Z1245537944, InChI=1/C4H10N2/c1-2-6-4-3-5-1/h5-6H,1-4H, Piperazine, United States Pharmacopeia (USP) Reference Standard, TRIMETAZIDINE DIHYDROCHLORIDE IMPURITY G [EP IMPURITY]
Theoretical properties:
molecular_formula: C4H10N2
molecular_weight: 86.14 g/mol
exact_mass: 86.084398327 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 2
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 0
heavy_atom_count: 6
topological_polar_surface_area: 24.1 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
physical_state: Plates or leaflets from ethanol
color: Plates or leaflets from ethanol
odor: Typical amine odor
boiling_point: 295 °F at 760 mmHg (NTP, 1992)
melting_point: 223 °F (NTP, 1992)
density: 1.1 at 68 °F (NTP, 1992) - Denser than water; will sink
solubility: Very soluble (NTP, 1992)
flash_point: 190 °F (NTP, 1992)
vapor_pressure: 0.16 [mmHg]
Descriptions:
pubchem: Piperazine is an azacycloalkane that consists of a six-membered ring containing two nitrogen atoms at opposite positions. It has a role as an anthelminthic drug. It is a member of piperazines, a saturated organic heteromonocyclic parent and an azacycloalkane. It is a conjugate base of a piperazinium(2+).
chebi: An azacycloalkane that consists of a six-membered ring containing two nitrogen atoms at opposite positions.
chembl: PIPERAZINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Piperazine () is an organic compound with the formula (CH2CH2NH)2. In terms of its structure, it can be described as cyclohexane with the 1- and 4-CH2 groups replaced by NH. Piperazine exists as a deliquescent solid with a saline taste. Piperazine is freely soluble in water and ethylene glycol, but poorly soluble in diethyl ether.  Piperazine is commonly available industrially as the hexahydrate, (CH2CH2NH)2·6H2O, which melts at 44 °C and boils at 125–130 °C.
Substituted derivatives of piperazine are a broad class of chemical compounds. Many piperazines have useful pharmacological properties, with prominent examples including sildenafil, ciprofloxacin, and ziprasidone.