Compound: orphenadrine
SMILES: O(C(c1c(cccc1)C)c2ccccc2)CCN(C)C
InChIKey: QVYRGXJJSLMXQH-UHFFFAOYSA-N
Synonyms: orphenadrine, Orphenadrin, 83-98-7, Orphenadine, o-Methyldiphenhydramine, Orphenedrine, Brocadisipal, Orfenadrina, 2-Methyldiphenhydramine, Mefenamine, Orphenadrinum, 2-(Phenyl-o-tolylmethoxy)ethyldimethylamine, o-Monomethyldiphenhydramine, Mephenamine, N,N-dimethyl-2-(phenyl(o-tolyl)methoxy)ethanamine, Mialgin, Phenyl-o-tolylmethyl dimethyaminoethyl ether, WS 2434, Brocasipal, beta-Dimethylaminoethyl 2-methylbenzhydryl ether, AL805O9OG9, dimethyl({2-[(2-methylphenyl)(phenyl)methoxy]ethyl})amine, BS 5930, N,N-dimethyl-2-(alpha-2-tolylbenzoyloxy)ethylamine, CHEBI:7789, DTXSID3023396, Ethanamine, N,N-dimethyl-2-((2-methylphenyl)phenylmethoxy)-, Dimethyl-[2-(phenyl-o-tolyl-methoxy)-ethyl]-amine, Ethanamine, N,N-dimethyl-2-[(2-methylphenyl)phenylmethoxy]-, N,N-Dimethyl-2-[(o-methyl-alpha-phenylbenzyl)oxy]ethylamine, Ethylamine, N,N-dimethyl-2-((o-methyl-alpha-phenylbenzyl)oxy)-, Methyldiphenylhydramine, Dimethyl-(2-(phenyl-o-tolyl-methoxy)-ethyl)-amine, dimethyl((2-((2-methylphenyl)(phenyl)methoxy)ethyl))amine, N,N-dimethyl-2-((o-methyl-alpha-phenylbenzyl)oxy)ethylamine, Mefenamine, Sodium, (+-)-Orphenadrine, RefChem:55783, Hydrochloride, Orphenadrine, Citrate, Norflex Orphenadrine, Orphenadrine Citrate, Norflex, DTXCID003396, M03BC01, N04AB02, 201-509-2, Disipal, N,N-dimethyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine, CHEMBL900, Orphenadinum, Orphenadrine (INN), ORP, Orphenate, ORPHENADRINE [INN], Orphenadrine [INN:BAN], Orfenadrina [INN-Spanish], Orphenadrinum [INN-Latin], Mialgin (TN), HSDB 3139, EINECS 201-509-2, beta-Dimethylaminoethyl-2-methylbenzhydryl ether, N,N-Dimethyl-2-(alpha-2-tolylbenzoyloxy)ethylamin, BRN 1885151, UNII-AL805O9OG9, N,N-Dimethyl-2-(o-methyl-alpha-phenylbenzyl)oxy)ethylamine, Spectrum_001045, Brocasipal (Salt/Mix), Mephenamine (Salt/Mix), MEFENAMINE [JAN], Prestwick0_000239, Prestwick1_000239, Prestwick2_000239, Prestwick3_000239, Spectrum2_001038, Spectrum3_000531, Spectrum4_000460, Spectrum5_001036, ORPHENADRINE [MI], Phenyl-o-tolylmethyl dimethylaminoethyl ether, ORPHENADRINE [HSDB], ORPHENADRINE [VANDF], Lopac0_000884, Oprea1_476547, SCHEMBL28727, BSPBio_000317, BSPBio_002141, CBDivE_006102, KBioGR_000880, KBioSS_001525, 4-06-00-04727 (Beilstein Handbook Reference), DivK1c_000853, ORPHENADRINE [WHO-DD], SPBio_001255, SPBio_002238, BPBio1_000349, GTPL7251, orb1740881, SCHEMBL29359844, KBio1_000853, KBio2_001525, KBio2_004093, KBio2_006661, KBio3_001641, NINDS_000853, N,N-Dimethyl-2-[(2-methylphenyl)(phenyl)methoxy]ethanamine, N,N-dimethyl-2-{[(2-methylphenyl)(phenyl)methyl]oxy}ethanamine, BDBM50062614, EBC-26385, EX-A14980, BS-5930, CCG-204966, DB01173, SDCCGSBI-0050859.P005, IDI1_000853, NCGC00015771-03, NCGC00015771-05, NCGC00015771-06, NCGC00015771-07, NCGC00015771-09, NCGC00015771-10, NCGC00015771-12, NCGC00015771-22, NCGC00089814-02, NCGC00089814-03, NCGC00089814-05, SBI-0050859.P004, HY-157959, AB00053510, CS-1010546, NS00009478, ST50406606, C07935, D08305, dimethyl-2[alpha-(o-tolyl)benzyloxy]ethylamine, EN300-708773, AB00053510-19, AB00053510_20, AB00053510_21, .beta.-Dimethylaminoethyl 2-methylbenzhydryl ether, L001253, Q3292273, BRD-A53576514-003-03-1, BRD-A53576514-048-06-9, BRD-A53576514-048-13-5, BRD-A53576514-048-14-3, dimethyl{2-[(2-methylphenyl)phenylmethoxy]ethyl}amine, N,N-Dimethyl-2-[(2-methylphenyl)(phenyl)methoxy]ethan-1-amine, N,N-Dimethyl-2-[(2-methylphenyl)(phenyl)methoxy]ethanamine #, N,N-Dimethyl-2-[(o-methyl-.alpha.-phenylbenzyl)oxy]ethylamine, Ethylamine, N,N-dimethyl-2-((o-methyl-.alpha.-phenylbenzyl)oxy)-, (+/-)-N,N-DIMETHYL-2-((O-METHYL-.ALPHA.-PHENYLBENZYL)OXY)ETHYLAMINE, ETHANAMINE, N,N-DIMETHYL-2-((2-METHYLPHENYL)PHENYLMETHOXY)-, (+/-)-
Theoretical properties:
molecular_formula: C18H23NO
molecular_weight: 269.4 g/mol
exact_mass: 269.177964357 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 2
rotatable_bond_count: 6
heavy_atom_count: 20
topological_polar_surface_area: 12.5 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
physical_state: LIQUID
color: LIQUID
melting_point: < 25 °C
solubility: Sparingly soluble in water
Descriptions:
pubchem: Orphenadrine is a tertiary amino compound which is the phenyl-o-tolylmethyl ether of 2-(dimethylamino)ethanol. It has a role as a H1-receptor antagonist, an antiparkinson drug, a muscarinic antagonist, a parasympatholytic, a muscle relaxant, a NMDA receptor antagonist and an antidyskinesia agent. It is an ether and a tertiary amino compound.
chebi: A tertiary amino compound which is the phenyl-<em>o</em>-tolylmethyl ether of 2-(dimethylamino)ethanol.
chembl: ORPHENADRINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 4.0.
wikipedia: Orphenadrine is an anticholinergic drug of the ethanolamine antihistamine class; it is closely related to diphenhydramine. It is a muscle relaxant that is used to treat muscle pain and to help with motor control in Parkinson's disease, but has largely been superseded by newer drugs. It is considered a dirty drug due to its multiple mechanisms of action in different pathways. It was discovered and developed in the 1940s.