Compound: TRIMETOZINE
SMILES: O=C(N1CCOCC1)c2cc(OC)c(OC)c(c2)OC
InChIKey: XWVOEFLBOSSYGM-UHFFFAOYSA-N
Synonyms: TRIMETOZINE, 635-41-6, Trioxazine, 4-(3,4,5-Trimethoxybenzoyl)morpholine, Abbott-22370, Trimetozina, NSC-62939, PS 2383, Morpholine, 4-(3,4,5-trimethoxybenzoyl)-, Trimetozinum, PS-2383, 31EPT7G9PL, DTXSID8023713, DTXCID203713, RefChem:899933, 211-236-0, Sedoxazine, Opalene, Trimethoxazine, Trioxazin, Trifenoxazin, Trimetozin, Triksazin, Trimolide, NSC 62939, Trimetogine, LG 50043, N-(3,4,5-Trimethoxybenzoyl)morpholine, A 22370, 4-(3,4,5-Trimethoxybenzoyl)tetrahydro-1,4-oxazine, N-(3,4,5-Trimethoxybenzoyl)tetrahydro-1,4-oxazine, 3,4,5-Trimethoxybenzoyl-N-tetrahydroxazine, 4-Morpholinyl(3,4,5-trimethoxyphenyl)methanone, V 7, NSC62939, MFCD00023351, NCGC00159396-02, NCGC00159396-03, NCGC00159396-04, Trioxyfar, morpholin-4-yl 3,4,5-trimethoxyphenyl ketone, morpholino-(3,4,5-trimethoxyphenyl)methanone, Trimetozine [USAN:INN], Trimetozinum [INN-Latin], Trimetozina [INN-Spanish], CAS-635-41-6, EINECS 211-236-0, UNII-31EPT7G9PL, BRN 1085184, 4-(3,4,5-TRIMETHOXYBENZOYL)-MORPHOLINE, morpholin-4-yl-(3,4,5-trimethoxyphenyl)methanone, Spectrum_001594, SpecPlus_000359, TRIMETOZINE [MI], Spectrum5_001694, TRIMETOZINE [INN], Trimetozine (USAN/INN), TRIMETOZINE [USAN], NCIOpen2_003363, TRIMETOZINE [MART.], Oprea1_625609, Oprea1_784655, KBioSS_002074, TRIMETOZINE [WHO-DD], DivK1c_006455, SCHEMBL114786, orb1310803, CHEMBL1697853, CHEBI:92927, KBio1_001399, KBio2_002074, KBio2_004642, KBio2_007210, HMS2093C14, HMS3714C16, Pharmakon1600-01504214, HY-B1316, Morpholine,4,5-trimethoxybenzoyl)-, Tox21_111634, Tox21_111635, 4-(3,5-Trimethoxybenzoyl)morpholine, EBC-06817, N-(3,5-Trimethoxybenzoyl)morpholine, NSC758689, STL506099, AKOS000630263, Tox21_111634_1, CCG-213282, NSC-758689, N-(3,4,5Trimethoxybenzoyl)-morpholine, 3,5-Trimethoxybenzoyl-N-tetrahydroxazine, N-(3,4,5-Trimethoxybenzoyl)-morpholino, DA-68340, ST072000, SY473693, TS-07633, WLN: T6N DOTJ AVR CO1 DO1 EO1, SBI-0052916.P002, 3,4,5-Trimethoxy-N-benzoyltetrahydroxazine, CS-0013077, Morpholino(3,4,5-trimethoxyphenyl)methanone, NS00005467, T0240, D06237, H57338, 4-morpholinyl-(3,4,5-trimethoxyphenyl)methanone, AB00275229_02, EN300-6492982, morpholin-4-yl(3,4,5-trimethoxyphenyl)methanone, 4-(3,5-Trimethoxybenzoyl)tetrahydro-1,4-oxazine, AE-641/02482028, N-(3,5-Trimethoxybenzoyl)tetrahydro-1,4-oxazine, Q844489, SR-05000001892, (Morpholin-4-yl)(3,4,5-trimethoxyphenyl)methanone, SR-05000001892-1, 4-{[3,4,5-tris(methyloxy)phenyl]carbonyl}morpholine, BRD-K53220666-001-01-8, BRD-K53220666-001-02-6, Z28251506, METHANONE, 4-MORPHOLINYL(3,4,5-TRIMETHOXYPHENYL)-, TX
Theoretical properties:
molecular_formula: C14H19NO5
molecular_weight: 281.30 g/mol
exact_mass: 281.12632271 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 0
hydrogen_bond_acceptor_count: 5
rotatable_bond_count: 4
heavy_atom_count: 20
topological_polar_surface_area: 57.2 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: 4-morpholinyl-(3,4,5-trimethoxyphenyl)methanone is a member of morpholines.
chembl: TRIMETOZINE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 2.0.
wikipedia: Trimetozine (Opalene, Trimolide, Trioxazine) is a sedative that has been marketed in Europe since 1959. It also has mild tranquilizing effects and has been used in the treatment of anxiety. Its mechanism of action is unclear.
Conversion of the amide in trimetozine to the thioamide gives Tritiozine.