Compound: TYBAMATE
SMILES: O=C(OCC(COC(=O)N)(CCC)C)NCCCC
InChIKey: PRBORDFJHHAISJ-UHFFFAOYSA-N
Synonyms: TYBAMATE, Tibamato, Tybatran, Solacen, Effisax, Solacin, Tibamate, Tibamax, Benvil, Nospan, Depran, Idalene, Reposan, 4268-36-4, W 713, Tybamatum, 2-Methyl-2-propyltrimethylene butylcarbamate carbamate, N-Butyl-2-methyl-2-propyl-1,3-propanediol dicarbamate, 2-(Hydroxymethyl)-2-methylpentyl butylcarbamate carbamate, Carbamic acid, butyl-, 2-(((aminocarbonyl)oxy)methyl)-2-methylpentyl ester, NSC-172126, 3875LLL8M8, W-713, Carbamic acid, butyl-, 2-(hydroxymethyl)-2-methylpentyl ester carbamate (ester), NSC172126, DTXSID7023728, Carbamic acid, butyl-, 2-[[(aminocarbonyl)oxy]methyl]-2-methylpentyl ester, RefChem:900807, DTXCID503728, 224-254-9, 2-Methyl-2-propyl-1,3-propanediol butylcarbamate carbamate, NSC 172126, Carbamic acid, ester with 2-(hydroxymethyl)-2-methylpentyl butylcarbamate, [2-(carbamoyloxymethyl)-2-methylpentyl] N-butylcarbamate, N-n-Butyl-2-methyl-2-propyl-1,3-propanediol dicarbamate, 1,3-Propanediol, 2-methyl-2-propyl-, butylcarbamate carbamate, Carbamic acid, butyl-, 2-(hydroxymethyl)-2-methylpentyl ester, carbamate, Carbamic acid, butyl-, ester with 2-(hydroxymethyl)-2-methylpentyl carbamate, Carbamic acid, ester with 2-methyl-2-propyl-1,3-propanediol butylcarbamate, 2-(Hydroxymethyl)-2-(methylpentyl) butylcarbamate carbamate, Tybamatum [INN-Latin], Tibamato [INN-Spanish], Carbamic acid, butyl-, 2-(hydroxymethyl)-2-methylpentyl ester carbamate, HSDB 3410, EINECS 224-254-9, 2-[(carbamoyloxy)methyl]-2-methylpentyl butylcarbamate, BRN 1970468, UNII-3875LLL8M8, Tybamate [USAN:INN:BAN:NF], Solacen (TN), TYBAMATE [HSDB], TYBAMATE [USAN], Tybamate (USAN/INN), TYBAMATE [INN], TYBAMATE [MI], Butylcarbamic acid 2-(((aminocarbonyl)oxy)methyl)-2-methylpentyl ester, TYBAMATE [WHO-DD], Carbamate of 2-(hydroxymethyl)-2-methylpentyl ester of butylcarbamic acid, SCHEMBL78046, CHEMBL2104816, CHEBI:135133, WLN: ZVO1X3&1&1OVM4, Carbamic acid,3-propanediol butylcarbamate, NS00031223, D06260, 1, 2-methyl-2-propyl-, butylcarbamate carbamate, Q7859691, [2-(carbamoyloxymethyl)-2-methyl-pentyl] N-butylcarbamate, Carbamic acid, 2-(hydroxymethyl)-2-methylpentyl ester carbamate, 1, 3-Propanediol, 2-methyl-2-propyl-, butylcarbamate carbamate, Carbamic acid, ester with 2-(hydroxymethyl)-2-methylpentyl carbamate, Carbamic acid, ester with 2-methyl-2-propyl-1, 3-propanediol butylcarbamate, Carbamic acid, butyl-, {2-[[(aminocarbonyl)oxy]methyl]-2-methylpentyl} ester
Theoretical properties:
molecular_formula: C13H26N2O4
molecular_weight: 274.36 g/mol
exact_mass: 274.18925731 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 2
hydrogen_bond_acceptor_count: 4
rotatable_bond_count: 11
heavy_atom_count: 19
topological_polar_surface_area: 90.7 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
physical_state: CRYSTALS FROM 1,1,2-TRICHLOROETHANE + HEXANE (1:2)
color: CRYSTALS FROM 1,1,2-TRICHLOROETHANE + HEXANE (1:2)
odor: MILD CHARACTERISTIC ODOR
boiling_point: 150-152 °C @ 0.06 MM HG
melting_point: 49-51 °C
solubility: VERY SOL IN ALC & ACETONE; FREELY SOL IN ETHER; VERY SLIGHTLY SOL IN WATER
Descriptions:
pubchem: Tybamate is a carbamate ester.
chembl: TYBAMATE is a small molecule listed in the ChEMBL database and has reached clinical trial phase 2.0.
wikipedia: Tybamate (INN; Solacen, Tybatran, Effisax) is an anxiolytic of the carbamate family. It is a prodrug for meprobamate in the same way as the better known drug carisoprodol. It has liver enzyme inducing effects similar to those of phenobarbital but much weaker.
As the trade name Tybatran (Robins), it was formerly available in capsules of 125, 250, and 350 mg, taken 3 or 4 times a day for a total daily dosage of 750 mg to 2 g. The plasma half-life of the drug is three hours. At high doses in combination with phenothiazines, it could produce convulsions.