Compound: forskolin
SMILES: O=C1[C@@]2(O)[C@](O[C@](C1)(C=C)C)([C@@H](OC(=O)C)[C@@H](O)[C@@H]3[C@@]2([C@@H](O)CCC3(C)C)C)C
InChIKey: OHCQJHSOBUTRHG-KGGHGJDLSA-N
Synonyms: forskolin, Colforsin, 66575-29-9, Coleonol, colforsina, colforsine, colforsinum, Boforsin, Coleonolk, HL 362, L 75 1362B, HL-362, 7beta-Acetoxy-8,13-epoxy-1alpha,6beta,9alpha-trihydroxylabd-14-en-11-one, 1F7A44V6OU, DTXSID8040484, L-751362B, NSC-357088, NSC-375489, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1H-benzo[f]chromen-5-yl acetate, [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate, DTXCID6020484, L-75-1362B, CHEBI:42471, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-dodecahydro-1H-naphtho[2,1-b]pyran-5-yl acetate, ((3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo(f)chromen-5-yl) acetate, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-dodecahydro-1H-naphtho(2,1-b)pyran-5-yl acetate, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1H-benzo(f)chromen-5-yl acetate, RefChem:578508, 266-410-9, N,N-dimethyl-beta-alanine-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho(2,1-b)pyran-6-yl ester HCl, (-)-Forskolin, MFCD00082317, Forskolin (GMP), (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-5-yl acetate, CHEMBL52606, 66428-89-5, NSC375489, NCGC00024996-02, 64657-11-0, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-Dodecahydro-5,6,10,10b-tetrahydroxy-3,4a,7,7,10a-pentamethyl-3-vinyl-1H-naphtho(2,1-b)pyran-1-one 5-acetate, Colforsine [French], Colforsinum [Latin], Colforsina [Spanish], Coleonol;Colforsin, ForsLean, Colforsin [USAN:INN], [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyl-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate, 1H-Naphtho[2,1-b]pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-, FOK, SMR000471881, CAS-66575-29-9, EINECS 266-410-9, NSC 357088, NSC 375489, UNII-1F7A44V6OU, Forscoline, Ocufors, Forskolin?, Timsaponin-C, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-Dodecahydro-5,6,10,10b-tetrahydroxy-3,4a,7,7,10a-pentamethyl-3-vinyl-1H-naphtho[2,1-b]pyran-1-one 5-acetate, Forskolin (Standard), COLFORSIN [INN], COLFORSIN [MI], Colforsin (USAN/INN), COLFORSIN [USAN], FORSKOLIN [VANDF], COLFORSIN [MART.], MolMap_000021, 7-beta-Acetoxy-8,13-epoxy-1-alpha,6-beta,9-alpha-trihydroxylabd-14-en-11-one, COLFORSIN [WHO-DD], FORSKOLIN [USP-RS], SCHEMBL4928, cid_47936, MLS001066384, MLS001333255, MLS001333256, MLS002172462, MLS002695942, Forskolin, analytical standard, Forskolin - Bio-X trade mark, REGID_for_CID_47936, GTPL5190, BCBcMAP01_000132, OHCQJHSOBUTRHG-KGGHGJDLSA-, Bio1_000443, Bio1_000932, Bio1_001421, GLXC-05197, HMS2235C17, HMS3267I16, HMS3412G19, HMS3676G19, EX-A5963, Tox21_110940, Tox21_302399, BDBM50010261, HB1348, HY-15371G, HY-15371R, s2449, AKOS024456384, Tox21_110940_1, CCG-268774, CS-1454, DB02587, EBC-157221, FF23593, LMPR0104030004, SMP1_000128, NCGC00024996-03, NCGC00024996-04, NCGC00024996-05, NCGC00024996-06, NCGC00024996-07, NCGC00024996-10, NCGC00024996-34, NCGC00177971-03, NCGC00255526-01, [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl]acetate, 1H-Naphtho(2,1-b)pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, 1H-Naphtho(2,1-b)pyran-1-one, 5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-, (3R-(3alpha,4abeta,5beta,6beta,6aalpha,10alpha,10abeta,10balpha))-, 1H-Naphtho(2,1-b)pyran-1-one, dodecahydro-5-(acetyloxy)-3-ethenyl-3,4a,7,7,10a-pentamethyl-6,10,10b-trihydroxy-, (3R-(3-alpha,4a-beta,5-beta,6-beta,6a-alpha,10-alpha,10a-beta,10b-alpha))-, 5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho(2,1-b)pyran-1-one, AC-33150, AS-17443, BF164487, FF170900, HY-15371, SY076754, CS-0622781, F0855, M-410, NS00020690, C09076, D03584, MLS-0318096.0001, Q412747, SR-01000597378, FORSKOLIN (CONSTITUENT OF FORSKOHLII) [DSC], Forskolin, For use in molecular biology applications, SR-01000597378-1, BRD-K09602097-001-04-5, BRD-K09602097-001-13-6, Z1395264745, Forskolin, from Coleus forskohlii, >=98% (HPLC), powder, Forskolin, United States Pharmacopeia (USP) Reference Standard, 7beta-acetoxy-1alpha,6beta,9alpha-trihydroxy-8,13-epoxy-labd-14-en-11-one, Coleonol;7beta-Acetoxy-8,13-epoxy-1alpha,6beta,9alpha-trihydroxylabd-14-en-11-one, (3R,4?R,5S,6S,6?S,10S,10?R,10?S)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10?-trihydroxy-3,4?,7,7,10?-pentamethyl-1H-naphtho[2,1-?]py ran-1-one, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-Ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxododecahydro-1H-naphtho[2,1-b]pyran-5-yl acetate, [3R-(3a,4ab,5b,6b,6aa,10a,10ab,10ba)]-5-(Acetyloxy)-3-e thenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one, InChI=1/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1
Theoretical properties:
molecular_formula: C22H34O7
molecular_weight: 410.5 g/mol
exact_mass: 410.23045342 g/mol
formal_charge: 0
hydrogen_bond_donor_count: 3
hydrogen_bond_acceptor_count: 7
rotatable_bond_count: 3
heavy_atom_count: 29
topological_polar_surface_area: 113 Å²
isotope_atom_count: 0
covalently_bonded_unit_count: 1
Physical properties:
Descriptions:
pubchem: Forskolin is a labdane diterpenoid isolated from the Indian Coleus plant. It has a role as an antihypertensive agent, a platelet aggregation inhibitor, an anti-HIV agent, a plant metabolite, a protein kinase A agonist and an adenylate cyclase agonist. It is a tertiary alpha-hydroxy ketone, an organic heterotricyclic compound, a triol, a labdane diterpenoid, a cyclic ketone and an acetate ester.
chebi: A labdane diterpenoid isolated from the Indian <em>Coleus</em> plant.
chembl: COLFORSIN is a small molecule listed in the ChEMBL database and has reached clinical trial phase 2.0.
wikipedia: Forskolin (coleonol) is a labdane diterpene produced by the plant Coleus barbatus (blue spur flower). Other names include pashanabhedi, Indian coleus, makandi, HL-362, mao hou qiao rui hua. As with other members of the large diterpene class of plant metabolites, forskolin is derived from geranylgeranyl pyrophosphate (GGPP). Forskolin contains some unique functional elements, including the presence of a tetrahydropyran-derived heterocyclic ring. 
Forskolin is commonly used in laboratory research to increase levels of cyclic AMP by stimulation of adenylate cyclase.
The name comes from an obsolete name for the plant, Plectranthus forskolaei (see Coleus barbatus).