What are fms-like tyrosine kinase 3 (FLT3) inhibitors?
The FLT3 gene gives instructions for making a protein known as fms-like tyrosine kinase 3 (FLT3). FLT3 is recognized as a part of a family of proteins called receptor tyrosine kinases (RTKs) which transmit signals from the cell surface into the cell through a process known as signal transduction. This signaling mechanism tends to control many crucial cellular processes, including cell proliferation and survival, specifically of early blood cells called hematopoietic progenitor cells. Any changes in the FLT3 gene result in the form of blood cancer, predominantly FLT3 mutated acute myeloid leukemia (AML).
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