I weigh 200 lbs and sleep on my stomach and side. It took a few days to adjust to but now I love my mattress. It sleeps relatively cool and the pressure relief is out of this world. I can stay on my side all night and I don't have any numb fingers or shoulder pain when I wake up. I have chronic low back pain and the zone support works extremely well. I haven't had back pain in weeks. I am unsure of the nanobionic effect. 
I've slept on a celliant mattress that I actually felt the active recovery in my body but I'm not experiencing that with this bed as of yet which is disappointing. It's a pricey mattress but it's worth every penny as a restful sleep is so important. Customer service was also excellent and answered all of my questions. I would highly recommend.