AllerEase Maximum Waterproof Allergy and Bedbug Zippered Mattress Protector is just what I needed. I suffer from bad allergies and was really glad to get this.
It is very easy to put on your mattress. I vacuumed my mattress and box spring first to remove any dust, dander, etc. before putting the mattress protector on.
Then I flipped my mattress on it's side, slid the protector on, zipped it up, and was done! 
It is really soft and can be used without a bottom sheet in my opinion.
I would recommend this to anyone who suffers from allergies, and doesn't want to worry about bedbugs stopping by!