Séquence du gène iso-1 localisé sur le chromosome 7DS du blé Triticum aestivum de l’exemple 1, dans laquelle apparaît la variation génétique GA (ApA-0866), sur l’exon 11 1 CTTCACGCCA GAAGATCTCA AGGCGGTGGG GTTGCCTCCC GAGTAGAGTT CATCAGCTTT GCGTGCGCCG CGCGCCCCCT TTTCTGGCCT GCGATTTAAG GAAGTGCGGT CTTCTAGAGT TCCGCCACCC CAACGGAGGG CTCATCTCAA GTAGTCGAAA CGCACGCGGC GCGCGGGGGA AAAGACCGGA CGCTAAATTC Exon 2 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 101 TTTTGTACTG GGGGAAATGC TGCAGGATAG GGTGACGGAG GAGGTTTCCC TTGACCCCCT GATGAATCGG ACTGGGAACG TGTGGCATGT CTTCATTGAA AAAACATGAC CCCCTTTACG ACGTCCTATC CCACTGCCTC CTCCAAAGGG AACTGGGGGA CTACTTAGCC TGACCCTTGC ACACCGTACA GAAGTAACTT Exon 2 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 201 GGCGAGCTGC ACGACATGCT TTACGGGTAC AGGTTCGACG GCACCTTTGC TCCTCACTGC GGGCACTACC TTGATATTTC CAATGTCGTG GTGGATCCTT CCGCTCGACG TGCTGTACGA AATGCCCATG TCCAAGCTGC CGTGGAAACG AGGAGTGACG CCCGTGATGG AACTATAAAG GTTACAGCAC CACCTAGGAA Exon 2 Exon 3 ~~~~~~~~ ~~ 301 ATGCTAAGGT GATCATACTT TAGCTTTACC TGCATCTTGG TATTTACAGT AGAAATTGTT ACGTGGACCC TTATTTGTTG CCTTTTGTGT TGCTCTAGGC TACGATTCCA CTAGTATGAA ATCGAAATGG ACGTAGAACC ATAAATGTCA TCTTTAACAA TGCACCTGGG AATAAACAAC GGAAAACACA ACGAGATCCG Exon 3 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 401 AGTGATAAGC CGAGGGGAGT ATGGCGTTCC GGCGCGTGGT AACAATTGCT GGCCTCAGAT GGCTGGCATG ATCCCTCTTC CATATAGCAC GGTATGCCTG TCACTATTCG GCTCCCCTCA TACCGCAAGG CCGCGCACCA TTGTTAACGA CCGGAGTCTA CCGACCGTAC TAGGGAGAAG GTATATCGTG CCATACGGAC 501 ATTGCTGAAA ATATTGGCTG CATTTGTTTC TCTCTTTTTC TCATATTTTT CTCCTGTCTT TCACTTGTAC TACATTGCCT CAGACAGTCA TGATCAAAGA TAACGACTTT TATAACCGAC GTAAACAAAG AGAGAAAAAG AGTATAAAAA GAGGACAGAA AGTGAACATG ATGTAACGGA GTCTGTCAGT ACTAGTTTCT 601 GAGCAGTGTC ATTAGACATT TGTAGTTGTC TGCTGACTTT GACCAAAACT TGTAATTTAC TGTTGTTAAA GGTCCTTGAA TCATATTTTT TTATAATATT CTCGTCACAG TAATCTGTAA ACATCAACAG ACGACTGAAA CTGGTTTTGA ACATTAAATG ACAACAATTT CCAGGAACTT AGTATAAAAA AATATTATAA Exon 4 ~ 701 ATGTTTGCAA GTGGAAGTGA AGTGAAATTG CATCTAGTAT TTGTTGTTGC TGTCTTAGTC GTTTAATTGG ACATGCAGTA AAAAGGTTTG CATCTGCAGT TACAAACGTT CACCTTCACT TCACTTTAAC GTAGATCATA AACAACAACG ACAGAATCAG CAAATTAACC TGTACGTCAT TTTTCCAAAC GTAGACGTCA Exon 4 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 801 TTGATTGGGA AGGCGACCTA CCTCTAAGAT ATCCTCAAAA GGACCTGGTA ATATATGAGA TGCACTTGCG TGGATTCACG AAGCATGATT CAAGCAATGT AACTAACCCT TCCGCTGGAT GGAGATTCTA TAGGAGTTTT CCTGGACCAT TATATACTCT ACGTGAACGC ACCTAAGTGC TTCGTACTAA GTTCGTTACA Exon 4 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 901 AGAACATCCG GGTACTTTCA TTGGAGCTGT GTCGAAGCTT GACTATTTGA AGGTACAGCT GTACTTGCTG ACTACATAGG ATAATTTTTA AAGAAAGCTA TCTTGTAGGC CCATGAAAGT AACCTCGACA CAGCTTCGAA CTGATAAACT TCCATGTCGA CATGAACGAC TGATGTATCC TATTAAAAAT TTCTTTCGAT 1001 CATATTAGCC AGAATTTGGG TTATTACAAA AACTACTGCA TACTATAGCA GTTACATGCT CATTATCGAG GAGATGCTCA CACGCATCTT ATTTGGATTT GTATAATCGG TCTTAAACCC AATAATGTTT TTGATGACGT ATGATATCGT CAATGTACGA GTAATAGCTC CTCTACGAGT GTGCGTAGAA TAAACCTAAA Exon 5 ~~~~~~~~~ 1101 AATACCCAAT TCTGTAATCA TGACTAAATA TGTTTTCCCA GATCTGCTTA TGAATTCCGT ATTATTTGAT ATTGGACTGT TCCCTCTACA GGAGCTTGGA TTATGGGTTA AGACATTAGT ACTGATTTAT ACAAAAGGGT CTAGACGAAT ACTTAAGGCA TAATAAACTA TAACCTGACA AGGGAGATGT CCTCGAACCT Exon 5 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1201 GTTAATTGTA TTGAATTAAT GCCCTGCCAT GAGTTCAACG AGCTGGAGTA CTCAACCTCT TCTTCCAAGT AAGGACATGA ATTTAGTATT AGCCTGCCAG CAATTAACAT AACTTAATTA CGGGACGGTA CTCAAGTTGC TCGACCTCAT GAGTTGGAGA AGAAGGTTCA TTCCTGTACT TAAATCATAA TCGGACGGTC 1301 CACTGTTTGA GTGAGAGTTC ATACACATTT TGTGCCTGCA TAACTGATAT TTGTTCAAAC TATTTTTTTT AGCAGTCACT CAACAGTTTT ACATATATAT GTGACAAACT CACTCTCAAG TATGTGTAAA ACACGGACGT ATTGACTATA AACAAGTTTG ATAAAAAAAA TCGTCAGTGA GTTGTCAAAA TGTATATATA 1401 ATAATATAGA CTATTCGTCA CCCTGGGTGA GGAATAGTTA TTCTTCACCC ACCTCTATTT TAACATCTAT GCACCGTAAT TTTACGTTTC GTAAATTTTG TATTATATCT GATAAGCAGT GGGACCCACT CCTTATCAAT AAGAAGTGGG TGGAGATAAA ATTGTAGATA CGTGGCATTA AAATGCAAAG CATTTAAAAC 1501 TCTTATTTTA GAGATAAAAA GAGAACGTAA GAAAACCTAT AATCGTCGTA AAAAAAAATT ATGTTACGTA AAATTACAAA TGTAAAAACA TAGTGTAAAA AGAATAAAAT CTCTATTTTT CTCTTGCATT CTTTTGGATA TTAGCAGCAT TTTTTTTTAA TACAATGCAT TTTAATGTTT ACATTTTTGT ATCACATTTT 1601 TGTACATAAA ATACATTTTT TGACCTATAT TTTTTTGTTA ATGCCAAATT TTATACAGTA AATCAATATG AATGTAACTA TTTGTATTTC AAATGTAATT ACATGTATTT TATGTAAAAA ACTGGATATA AAAAAACAAT TACGGTTTAA AATATGTCAT TTAGTTATAC TTACATTGAT AAACATAAAG TTTACATTAA 1701 TATTTATGAA ATGGTCGTAA GATTACCTCG GGTGAAGAAT AACTTATTCT GCACCCTGGG TGATGAATAG TAACACTATA TATATATATA NNNNNNNNNN ATAAATACTT TACCAGCATT CTAATGGAGC CCACTTCTTA TTGAATAAGA CGTGGGACCC ACTACTTATC ATTGTGATAT ATATATATAT NNNNNNNNNN 1801 NNNNNNNNNT ATACCGGCTG CTGCTAATGA TGTTAATATT TCGCAAGTAC CTAAGCTGGA TTTTTCTCCA TGAGACATCA ATCCATAATT GAAATTGGTC NNNNNNNNNA TATGGCCGAC GACGATTACT ACAATTATAA AGCGTTCATG GATTCGACCT AAAAAGAGGT ACTCTGTAGT TAGGTATTAA CTTTAACCAG 1901 ACGACAGTTG AATAGTTGAT AGCTGAAAAT GAAATCCAGC ATGCTACTGT CTTGCCATCT CCAGACTTGC TAACATGAAT TTTGTCTGCC TACCTGTCAT TGCTGTCAAC TTATCAACTA TCGACTTTTA CTTTAGGTCG TACGATGACA GAACGGTAGA GGTCTGAACG ATTGTACTTA AAACAGACGG ATGGACAGTA 2001 TTGTACCAAC GTTCCCAATT GCCCTCTCAT TATTCGTGTG TACCATGCAT ATGTGTTTTA ACATGATTAT TGTTGGCTAT ATTTCTCTTT GGAAACATGA AACATGGTTG CAAGGGTTAA CGGGAGAGTA ATAAGCACAC ATGGTACGTA TACACAAAAT TGTACTAATA ACAACCGATA TAAAGAGAAA CCTTTGTACT Exon 6 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 2101 CTAATTTATC ACCGTTTTGT ATAAACTGCT TGTTTTCATA TCAGGATGAA CTTTTGGGGA TATTCTACCA TAAACTTCTT TTCACCAATG ACGAGATACA GATTAAATAG TGGCAAAACA TATTTGACGA ACAAAAGTAT AGTCCTACTT GAAAACCCCT ATAAGATGGT ATTTGAAGAA AAGTGGTTAC TGCTCTATGT Exon 6 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 2201 CATCAGGCGG GATAAAAAAC TGTGGGCGTG ATGCCATAAA TGAGTTCAAA ACTTTTGTAA GAGAGGCTCA CAAACGGGGA ATTGAGGTAA GCAAGTCGTA GTAGTCCGCC CTATTTTTTG ACACCCGCAC TACGGTATTT ACTCAAGTTT TGAAAACATT CTCTCCGAGT GTTTGCCCCT TAACTCCATT CGTTCAGCAT Exon 7 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 2301 CGAGTTAGTT GCTCCTTTTG AACTTATCAA TTTGATGCGA AGACATGTTA CTGCTAGATG ATCCTGGATG TTGTCTTCAA CCATACAGCT GAGGGTAATG GCTCAATCAA CGAGGAAAAC TTGAATAGTT AAACTACGCT TCTGTACAAT GACGATCTAC TAGGACCTAC AACAGAAGTT GGTATGTCGA CTCCCATTAC Exon 7 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 2401 AGAATGGTCC AATATTATCA TTTAGGGGGG TCGATAATAC TACATACTAT ATGCTTGCAC CCAAGGTGAC AGATCTTTCT TGCTGCGTAA TTGTTCTTTC TCTTACCAGG TTATAATAGT AAATCCCCCC AGCTATTATG ATGTATGATA TACGAACGTG GGTTCCACTG TCTAGAAAGA ACGACGCATT AACAAGAAAG Exon 8 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 2501 ATAGATGTAT AGAGCATAGA TGTGTTATGT AGTAGTTCTT TTTCAAGGGG ATTATGTTCA TGCAGGGAGA GTTTTATAAC TATTCTGGCT GTGGGAATAC TATCTACATA TCTCGTATCT ACACAATACA TCATCAAGAA AAAGTTCCCC TAATACAAGT ACGTCCCTCT CAAAATATTG ATAAGACCGA CACCCTTATG Exon 8 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 2601 CTTCAACTGT AATCATCCTG TGGTTCGTCA ATTCATTGTA GATTGTTTAA GGTACAGATA TACATTTTAC TTCTAGAACT ACTTTTTCAT TTCTTTTGCT GAAGTTGACA TTAGTAGGAC ACCAAGCAGT TAAGTAACAT CTAACAAATT CCATGTCTAT ATGTAAAATG AAGATCTTGA TGAAAAAGTA AAGAAAACGA 2701 GCTTGTCATT TTGATATGAT TAATTTGCAA GCTTGTGGGG GTAAATCTTT TGGTCAGCAT ATTGTATCTT TAAATGTCAC AAATACTAAT GTCCTGGTGC CGAACAGTAA AACTATACTA ATTAAACGTT CGAACACCCC CATTTAGAAA ACCAGTCGTA TAACATAGAA ATTTACAGTG TTTATGATTA CAGGACCACG Exon 9 ~~~~~~~~~~~~ 2801 TTATTGATTT GGCATCTTCA AATTCTTCTC CAATGAAAAG GGAAAAATCT ACTGTATGTC TCGTCAACTA ATTTACTTTT GTTTTGCAGA TACTGGGTGA AATAACTAAA CCGTAGAAGT TTAAGAAGAG GTTACTTTTC CCTTTTTAGA TGACATACAG AGCAGTTGAT TAAATGAAAA CAAAACGTCT ATGACCCACT Exon 9 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 2901 TGGAAATGCA TGTTGATGGT TTTCGTTTTG ATCTTGCATC CATAATGACC AGAGGTTCCA GGTAATTTGT ATTTATTGTT TGTTTGCGTG TTGCCTTTTC ACCTTTACGT ACAACTACCA AAAGCAAAAC TAGAACGTAG GTATTACTGG TCTCCAAGGT CCATTAAACA TAAATAACAA ACAAACGCAC AACGGAAAAG Exon 10 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 3001 AGAAGATTCT TAAAAGAATG TTTCTTTTAC AAGTCTGTGG GATCCAGTTA ACGTGTATGG AGCTCCAATA GAAGGTGACA TGATCACAAC AGGGACACCT TCTTCTAAGA ATTTTCTTAC AAAGAAAATG TTCAGACACC CTAGGTCAAT TGCACATACC TCGAGGTTAT CTTCCACTGT ACTAGTGTTG TCCCTGTGGA Exon 10 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 3101 CTTGTTACTC CACCACTTAT TGACATGATC AGCAATGACC CAATTCTTGG AGGCGTCAAG GTACTTGTTT CATCCAACAC CTGTTGTCTG TGTGCATTCA GAACAATGAG GTGGTGAATA ACTGTACTAG TCGTTACTGG GTTAAGAACC TCCGCAGTTC CATGAACAAA GTAGGTTGTG GACAACAGAC ACACGTAAGT 3201 ATTGTTTTAA TATGGTAATG ATCAATTTCC CAATGTTGAT AAGGAAAAAA AATGCAAGTA GCTCTCTTTA TCTGCTTCTT GTGAGTTATG CTAAACATGT TAACAAAATT ATACCATTAC TAGTTAAAGG GTTACAACTA TTCCTTTTTT TTACGTTCAT CGAGAGAAAT AGACGAAGAA CACTCAATAC GATTTGTACA Exon 11 ~~~~~~~~~~~~ 3301 AGATACTACT ATATTTCAAC TGTATATACT TGACATATTA TTGCTTCCTT GGGAGGCTCT CTTATTCCTT TCCCCCGTTG CAATTATAGC TCATTGCTGA TCTATGATGA TATAAAGTTG ACATATATGA ACTGTATAAT AACGAAGGAA CCCTCCGAGA GAATAAGGAA AGGGGGCAAC GTTAATATCG AGTAACGACT Exon 11 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 3401 AGCATGGGAT GCAGGAGGCC TCTATCAAGT AGGTCAATTC CCTCACTGGA ATGTTTGGTC TGAGTGGAAT GGGAAGGTAA GGTACCTGTT AAAAGTTTGA TCGTACCCTA CGTCCTCCGG AGATAGTTCA TCCAGTTAAG GGAGTGACCT TACAAACCAG ACTCACCTTA CCCTTCCATT CCATGGACAA TTTTCAAACT 3501 ATGGCAAATA CTGATAGAAA TATAACTTAT ATTTGCGACA TATATAGATA AAGCAAAATA ATACGCATTC CACCTGAACT TTAAAGGGGC ACGCAGAATT TACCGTTTAT GACTATCTTT ATATTGAATA TAAACGCTGT ATATATCTAT TTCGTTTTAT TATGCGTAAG GTGGACTTGA AATTTCCCCG TGCGTCTTAA 3601 ATCCCGCATC TGTCTACAAG AATGATAACA CATGTGCTGA ATAGTGAAGT ACTACTTCTC AAATGTCTGA ATGAACGCAC TAACTCTTGT GAGTGTCAAC TAGGGCGTAG ACAGATGTTC TTACTATTGT GTACACGACT TATCACTTCA TGATGAAGAG TTTACAGACT TACTTGCGTG ATTGAGAACA CTCACAGTTG 3701 CGAGCAAGAA ATATTTGAGT TTTCTGCAAG AAATTGTTCA TGTTGTGCTG TATTATACTC CCTCCGTCCG AAATTATTTG TCGGAGAAAT GGATGTATCT GCTCGTTCTT TATAAACTCA AAAGACGTTC TTTAACAAGT ACAACACGAC ATAATATGAG GGAGGCAGGC TTTAATAAAC AGCCTCTTTA CCTACATAGA 3801 AGACGTATTT TAGTTCTAGA TACATCCATT TTTATCCATT TCTGCAACAA GTAGTTCCGG ACGGAGGGAG TATCATTTAA CAAATATATG CATGTTCGAA TCTGCATAAA ATCAAGATCT ATGTAGGTAA AAATAGGTAA AGACGTTGTT CATCAAGGCC TGCCTCCCTC ATAGTAAATT GTTTATATAC GTACAAGCTT 3901 GTAAATCCCC ACGAATAAGC ATATAAGACG ATATTGCTTT TTGACTTGTA ACACCTAAAC CTCATTGTTT TCTCCTAGGA TTTTGGGTGT TCGAAGCAAG CATTTAGGGG TGCTTATTCG TATATTCTGC TATAACGAAA AACTGAACAT TGTGGATTTG GAGTAACAAA AGAGGATCCT AAAACCCACA AGCTTCGTTC 4001 CAGCTGGTGA TATTTAATTT ACCTTTGCCT TTATTTGTAG CTTGATTTGA GGGTGCGGCA AAGGTTTTAG CTTAGTAGTG TTTTGTAAAT TATTATAGTT GTCGACCACT ATAAATTAAA TGGAAACGGA AATAAACATC GAACTAAACT CCCACGCCGT TTCCAAAATC GAATCATCAC AAAACATTTA ATAATATCAA 4101 TATGTATATA CTCCTCATTT GGGCACTTCC GTACTGGTCC CATAGAAGAT AAAAATGGAA TGATCACGAA TTCTGGGTGT CTGGCCAATA ATTGTTGACA ATACATATAT GAGGAGTAAA CCCGTGAAGG CATGACCAGG GTATCTTCTA TTTTTACCTT ACTAGTGCTT AAGACCCACA GACCGGTTAT TAACAACTGT 4201 ACACTGTTGC GCATTTGATT TTTATCAGGG AATGGAAAAT TGAAATCGGT AAGAAACATT GCGATATTAA GCTTGTATAT GCTAATGCTG GTGGATCTTT TGTGACAACG CGTAAACTAA AAATAGTCCC TTACCTTTTA ACTTTAGCCA TTCTTTGTAA CGCTATAATT CGAACATATA CGATTACGAC CACCTAGAAA 4301 AAGAGGGAAC ATATGATCTC GTGTGCATCC ATCTTCAACT AAAAAAATAT GTTGCACATC TCCCACGTCA CTTACTAGCT ATTTCATCCA AGTACTAACT TTCTCCCTTG TATACTAGAG CACACGTAGG TAGAAGTTGA TTTTTTTATA CAACGTGTAG AGGGTGCAGT GAATGATCGA TAAAGTAGGT TCATGATTGA G->A (ApA-0866) ~ Exon 12 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 4401 TGTGTGGTTG TCTCCTCAGT ACCGGGACAT TGTGCGCCAA TTCATTAAAG GCACTGATGG ATTTGCTGGT GGTTTTGCCG AATGTCTTTG TGGAAGTCCA ACACACCAAC AGAGGAGTCA TGGCCCTGTA ACACGCGGTT AAGTAATTTC CGTGACTACC TAAACGACCA CCAAAACGGC TTACAGAAAC ACCTTCAGGT Exon 12 ~~~~~~~~~~~~~ 4501 CACCTATACC AGGTAAGTTG TGGCAATACT TGGAAATGGG TTGAGTGAAT GTCACATGGA TTTTTTATAT ATACCACATG ATGATACACA TGTAAATATA GTGGATATGG TCCATTCAAC ACCGTTATGA ACCTTTACCC AACTCACTTA CAGTGTACCT AAAAAATATA TATGGTGTAC TACTATGTGT ACATTTATAT 4601 TAACGATTAT AGTGTATGCA TATGCATTTG GCTAAGAAGT ACTCCCTCCC TTAGTAAAAG TTAGTACAAA GTTGAGTCAT CTATTTTGGA ACGGAGGGAG ATTGCTAATA TCACATACGT ATACGTAAAC CGATTCTTCA TGAGGGAGGG AATCATTTTC AATCATGTTT CAACTCAGTA GATAAAACCT TGCCTCCCTC 4701 TATAAGTGTA TACACCAGTG CAATATATAG GTTTTAACAC CCAACTTGCC AATGAAGGAA CATAGGGCTT TCTAGTTATC TTATTTATTT GTCTGGTGAA ATATTCACAT ATGTGGTCAC GTTATATATC CAAAATTGTG GGTTGAACGG TTACTTCCTT GTATCCCGAA AGATCAATAG AATAAATAAA CAGACCACTT 4801 TAATCCACTG AAAAATTCCA GCCATGTCAT TTTTTAGGGG GGGAGAAGAA ACTATATTGA TTTTTCCCCC TAAAAAAAGC CATCTCAGAT TTCATAGGTA ATTAGGTGAC TTTTTAAGGT CGGTACAGTA AAAAATCCCC CCCTCTTCTT TGATATAACT AAAAAGGGGG ATTTTTTTCG GTAGAGTCTA AAGTATCCAT 4901 ACTTGCTTTT CTGTAAAGAA ATGAAAACGA CTTCATACTT TCTGTCGATT ATAAGTGTAT ACACTAGTGC AATATATAGG TTTTAACACC CAACTTGCCA TGAACGAAAA GACATTTCTT TACTTTTGCT GAAGTATGAA AGACAGCTAA TATTCACATA TGTGATCACG TTATATATCC AAAATTGTGG GTTGAACGGT 5001 ATGAAGGAAC ATAGGGCTTT CTAGTTATCT TATTTATTTG TCTGGTGAAT AATCCACTGA AAAATTCCAG CCATGTCATT TTTTAGGGGG GGAGAAGAAA TACTTCCTTG TATCCCGAAA GATCAATAGA ATAAATAAAC AGACCACTTA TTAGGTGACT TTTTAAGGTC GGTACAGTAA AAAATCCCCC CCTCTTCTTT 5101 CTATATTGAT TTTTCCCCCT AAAAAAAGCC ATCTCAGATT TCATAGGTAA CTTGCTTTTC TGTAAAGAAA TGAAAACGAC TTCATACTTT CTGTCGGCGC GATATAACTA AAAAGGGGGA TTTTTTTCGG TAGAGTCTAA AGTATCCATT GAACGAAAAG ACATTTCTTT ACTTTTGCTG AAGTATGAAA GACAGCCGCG 5201 TAACTTAGCT CGATGTATAT TTGTAAGATG AATGCCAAAT TTAATTTGTC GGGTAATTTG ATCTGTTATT CACAAATTTC TATTTGGTTT CTCTAGCAAT ATTGAATCGA GCTACATATA AACATTCTAC TTACGGTTTA AATTAAACAG CCCATTAAAC TAGACAATAA GTGTTTAAAG ATAAACCAAA GAGATCGTTA Exon 13 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 5301 CAAACCAGTA ACTTGTTATT GGCACTGCAA TTTCTTATTG ATTAATCAGG CAGGAGGAAG GAAACCTTGG CACAGTATCA ACTTTGTATG TGCACATGAT GTTTGGTCAT TGAACAATAA CCGTGACGTT AAAGAATAAC TAATTAGTCC GTCCTCCTTC CTTTGGAACC GTGTCATAGT TGAAACATAC ACGTGTACTA Exon 13 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 5401 GGATTTACAC TGGGTGATTT GGTAACATAT AATAACAAGT ACAATTTACC AAATGGGGAG AACAATAGAG ATGGAGAAAA TCACAATCTT AGCTGGAATT CCTAAATGTG ACCCACTAAA CCATTGTATA TTATTGTTCA TGTTAAATGG TTTACCCCTC TTGTTATCTC TACCTCTTTT AGTGTTAGAA TCGACCTTAA Exon 13 ~~~~~~~~ 5501 GTGGGGAGGT AATTCTGAAC TCTCCTTTTT TTTTGAAATT TTCATGCTTT ACATAATAGT CAAATGGCTG ACAAATGTCG TTGTATGGTT CTCTCTACCT CACCCCTCCA TTAAGACTTG AGAGGAAAAA AAAACTTTAA AAGTACGAAA TGTATTATCA GTTTACCGAC TGTTTACAGC AACATACCAA GAGAGATGGA 5601 AAACCGTTAA GGCAGTAAGA GTTTCCCTAC AAGATCTCTT TGTTCGTATA ATTGTATTTT CTAGAGAAAA GTTGCCTTCA ATTTTGTGCA CGCGGCAGTA TTTGGCAATT CCGTCATTCT CAAAGGGATG TTCTAGAGAA ACAAGCATAT TAACATAAAA GATCTCTTTT CAACGGAAGT TAAAACACGT GCGCCGTCAT 5701 CAGGAATTGT GGTTATAAAT ATTGATACAG GCTGACCATC GTTACTAATA GGGGGAACAA TAAGCACATT TTTTTAATAG CAAAGGCATC ACCCTTGTTC GTCCTTAACA CCAATATTTA TAACTATGTC CGACTGGTAG CAATGATTAT CCCCCTTGTT ATTCGTGTAA AAAAATTATC GTTTCCGTAG TGGGAACAAG 5801 CGTTTCCAAT GAAATCACAG TATCCGAACC ATAAGTTTTA CAAGTATGCG TAGAGAGAAA TAAAGTATCA ACCCGGCAGA AACAGTTGTT TCAGGCGCAA GCAAAGGTTA CTTTAGTGTC ATAGGCTTGG TATTCAAAAT GTTCATACGC ATCTCTCTTT ATTTCATAGT TGGGCCGTCT TTGTCAACAA AGTCCGCGTT 5901 AGAGAAAAGG AAACGATATG CTCTATTACA TCAACCTTTT AGCATTTAGG GACGACCAGC ATCATCCCAT CTTCAATCAA CTGGAGCGAG GTCACCTCCA TCTCTTTTCC TTTGCTATAC GAGATAATGT AGTTGGAAAA TCGTAAATCC CTGCTGGTCG TAGTAGGGTA GAAGTTAGTT GACCTCGCTC CAGTGGAGGT 6001 ATCTTCTCAG CAGCCTCAGA GTGGTGACCT CCCAAGCAAG TGCATCAGCA TCCATCATCT GGGGGTTGGG CACATACCAT GAGCACAATC ACCTGAATTT TAGAAGAGTC GTCGGAGTCT CACCACTGGA GGGTTCGTTC ACGTAGTCGT AGGTAGTAGA CCCCCAACCC GTGTATGGTA CTCGTGTTAG TGGACTTAAA 6101 GATGAATTTT CCTCTGTTTA CCTTGCAGCA GACCCCTGCC GTATAAATGG TTTTAAATGA CAGCATGTTC TTTCAGTTTG AGCAAAATTT GTGCAATTGC CTACTTAAAA GGAGACAAAT GGAACGTCGT CTGGGGACGG CATATTTACC AAAATTTACT GTCGTACAAG AAAGTCAAAC TCGTTTTAAA CACGTTAACG Exon 14 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 6201 AAAGAAGCTT TAGAATCATG TGGAACATGC ACTTACATTT CATCTGAACA ATATAGGAAG GAGAATTCGC AAGATTGTCT GTCAAAAGAT TGAGGAAGAG TTTCTTCGAA ATCTTAGTAC ACCTTGTACG TGAATGTAAA GTAGACTTGT TATATCCTTC CTCTTAAGCG TTCTAACAGA CAGTTTTCTA ACTCCTTCTC Exon 14 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 6301 GCAGATGCGC AATTTCTTTG TTTGTCTCAT GGTTTCTCAA GTAAGACTTA TATCTGATCT CTTCAATTTT TGAGATTGCC TGTTTTTCAC AATGGCATAT CGTCTACGCG TTAAAGAAAC AAACAGAGTA CCAAAGAGTT CATTCTGAAT ATAGACTAGA GAAGTTAAAA ACTCTAACGG ACAAAAAGTG TTACCGTATA 6401 GTTGTCAGGT GAAACATCCA ATCCCAGTAT TAATAGAGCC AACATGAAGG GATTGCTTAT CTGAGATATC TGCCAAAGTT GAATTCTTAG ATTCACCTTC CAACAGTCCA CTTTGTAGGT TAGGGTCATA ATTATCTCGG TTGTACTTCC CTAACGAATA GACTCTATAG ACGGTTTCAA CTTAAGAATC TAAGTGGAAG Exon 15 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 6501 TTCAGTATTT CAGACCTTCT AAGCATTTTC ATTTTTTTTT TTCAATTGTT AGGGAGTTCC AATGTTTTAC ATGGGCGATG AATATGGCCA CACAAAAGGG AAGTCATAAA GTCTGGAAGA TTCGTAAAAG TAAAAAAAAA AAGTTAACAA TCCCTCAAGG TTACAAAATG TACCCGCTAC TTATACCGGT GTGTTTTCCC Exon 15 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 6601 GGCAACAACA ATACATACTG CCATGATTCT TATGTCAGTA CAATTTGGTC ACATATTGTT GTTCTAAGTA ACTATCTTCA AATCTTTGCA TTCATCCGTC CCGTTGTTGT TATGTATGAC GGTACTAAGA ATACAGTCAT GTTAAACCAG TGTATAACAA CAAGATTCAT TGATAGAAGT TTAGAAACGT AAGTAGGCAG Exon 16 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 6701 ATGGCTCTTC TGTAGGTCAA TTATTTTCGC TGGGATAAAA AAGAACAATA CTCTGACTTG CACAGATTCT GCTGCCTCAT GACCAAATTC CGCAAGTAAG TACCGAGAAG ACATCCAGTT AATAAAAGCG ACCCTATTTT TTCTTGTTAT GAGACTGAAC GTGTCTAAGA CGACGGAGTA CTGGTTTAAG GCGTTCATTC 6801 TATTCCGTTG AATAATTTCT GTGTAGAACC ACTGAAGGTG CCTCCAAACG CTAAGCGAGC AAGGTCAATT TCACACCCTA ATCAAGTTGG TGTTGTCTAT ATAAGGCAAC TTATTAAAGA CACATCTTGG TGACTTCCAC GGAGGTTTGC GATTCGCTCG TTCCAGTTAA AGTGTGGGAT TAGTTCAACC ACAACAGATA Exon 17 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 6901 TTGTGTATTT GATCTGCTGC ACTGTAGGGA GTGCGAGGGT CTTGGCCTTG AGGACTTTCC AACGGCCGAA CGGCTGCAGT GGCATGGTCA TCAGCCTGGG AACACATAAA CTAGACGACG TGACATCCCT CACGCTCCCA GAACCGGAAC TCCTGAAAGG TTGCCGGCTT GCCGACGTCA CCGTACCAGT AGTCGGACCC Exon 17 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 7001 AAGCCTGATT GGTCTGAGAA TAGCCGATTC GTTGCCTTTT CCATGGTACA CATATAGTTC TGACACTTCA CTATAGTTGT TTTAAAAAAG AAAATTTAAC TTCGGACTAA CCAGACTCTT ATCGGCTAAG CAACGGAAAA GGTACCATGT GTATATCAAG ACTGTGAAGT GATATCAACA AAATTTTTTC TTTTAAATTG Exon 18 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 7101 TCAAAAGTAA ATTATGGAGA GTTTTAGAAG TAACAAATAT CTTTATGTAT CTCACCACAG AAAGATGAAA GACAGGGCGA GATCTATGTG GCCTTCAACA AGTTTTCATT TAATACCTCT CAAAATCTTC ATTGTTTATA GAAATACATA GAGTGGTGTC TTTCTACTTT CTGTCCCGCT CTAGATACAC CGGAAGTTGT Exon 18 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 7201 CCAGCCACTT ACCGGCCGTT GTTGAGCTCC CAGAGCGCGC AGGGCGCCGG TGGGAACCGG TGGTGGACAC AGGCAAGCCA GCACCATATG ACTTCCTCAC GGTCGGTGAA TGGCCGGCAA CAACTCGAGG GTCTCGCGCG TCCCGCGGCC ACCCTTGGCC ACCACCTGTG TCCGTTCGGT CGTGGTATAC TGAAGGAGTG Exon 18 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 7301 CGACGACTTA CCTGATCGCG CTCTCACCAT ACACCAGTTC TCTCATTTCC TCAACTCCAA CCTCTACCCC ATGCTCAGCT ACTCATCGGT CATCCTAGTA GCTGCTGAAT GGACTAGCGC GAGAGTGGTA TGTGGTCAAG AGAGTAAAGG AGTTGAGGTT GGAGATGGGG TACGAGTCGA TGAGTAGCCA GTAGGATCAT Exon 18 ~~~~~~~~~~~~~~~~ 7401 TTGCGCCCTG ATGTTTGAGA GACAAATATA TACAGTAAAT AATATGTCTA TATGTAGTCC TTTGGCGTAT TATCAGTGTG CACAATTGCT CTATTGCCAG AACGCGGGAC TACAAACTCT CTGTTTATAT ATGTCATTTA TTATACAGAT ATACATCAGG AAACCGCATA ATAGTCACAC GTGTTAACGA GATAACGGTC 7501 TGATCTATTC GATCCACAGA TACATGTGCA AACTGCAAAG TTTCTGGTAA TCAGAGAAGT TTTTCCTGAT GACCAAGCTA GTATAACATT CATTGACAAT ACTAGATAAG CTAGGTGTCT ATGTACACGT TTGACGTTTC AAAGACCATT AGTCTCTTCA AAAAGGACTA CTGGTTCGAT CATATTGTAA GTAACTGTTA 7601 GGAGCAAAAA CAAAATGCAC AGAGCATGCT CTTCTGTCAG TGACACTGAA GGAAGACGAA CGATCCACAC CGCAGTCAGC AGGGCAGCAT AAGGAAGGTA CCTCGTTTTT GTTTTACGTG TCTCGTACGA GAAGACAGTC ACTGTGACTT CCTTCTGCTT GCTAGGTGTG GCGTCAGTCG TCCCGTCGTA TTCCTTCCAT 7701 GAAGAACCAG CAAAACGACC AGAGGATCTC CAGCTCGATC TGCTTGCTCT GCATGCCTGT GTCGATCATG ATTCGGTGCT TTCAGGATAT GTGATGCATC CTTCTTGGTC GTTTTGCTGG TCTCCTAGAG GTCGAGCTAG ACGAACGAGA CGTACGGACA CAGCTAGTAC TAAGCCACGA AAGTCCTATA CACTACGTAG 7801 TGTAGACCCT GCATCTCTGG CACAAGATGT ACCCGGCCTG CAACAACAAC AACAATAACA AGGGAAGCCG GTTGGTCGTC GGCGCCGGAG CTTAAGAAGA ACATCTGGGA CGTAGAGACC GTGTTCTACA TGGGCCGGAC GTTGTTGTTG TTGTTATTGT TCCCTTCGGC CAACCAGCAG CCGCGGCCTC GAATTCTTCT 7901 GGATGGAAAT TTAAGGTAGG AGAAAGAAAG AGAACTTACG GCCTTGCAGG TCGGGCAGCG GCGATAGATC CTGGGGCTGC TCTCGGACTT GACGTTGTTC CCTACCTTTA AATTCCATCC TCTTTCTTTC TCTTGAATGC CGGAACGTCC AGCCCGTCGC CGCTATCTAG GACCCCGACG AGAGCCTGAA CTGCAACAAG 8001 TTCTTCCCCT TGCAGAAGTC GCACAGCAGC CACCCCGTGC CGCCGCACCC TTCTTCGCAC TCTACACCTT CTTCCTTGGG ACAACAGCGC AGACGGCAGG AAGAAGGGGA ACGTCTTCAG CGTGTCGTCG GTGGGGCACG GCGGCGTGGG AAGAAGCGTG AGATGTGGAA GAAGGAACCC TGTTGTCGCG TCTGCCGTCC 8101 TGAGAATTGC TAGCTTGGAG GATCAGGTGC ATAACTTGAA CTCGTCAGAT GGTCATGGAT CACTGCGAGG CTTGAGAGAT GCTAACCTCC ATGTCCACGT ACTCTTAACG ATCGAACCTC CTAGTCCACG TATTGAACTT GAGCAGTCTA CCAGTACCTA GTGACGCTCC GAACTCTCTA CGATTGGAGG TACAGGTGCA 8201 CCGCCTCGAC CTCCG GGCGGAGCTG GAGGC