Séquence du gène iso-1 localisé sur le chromosome 7BS du blé Triticum aestivum de l’exemple 1, dans laquelle apparaît la variation génétique GA (ApA-2164), sur l’exon 4, et la variation génétique GA (ApA-1119), sur l’exon 9 : 1 CTTCACGCCA GAAGATCTCA AGGCGGTGGG GTTGCCTCCC GAGTAGAGTT CATCAGCTTT GCGTGCGCCG CGCGCCCCTT TTTTGGGCCT GCAATTTAAG GAAGTGCGGT CTTCTAGAGT TCCGCCACCC CAACGGAGGG CTCATCTCAA GTAGTCGAAA CGCACGCGGC GCGCGGGGAA AAAACCCGGA CGTTAAATTC Exon 2 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 101 TTTTGTACTG GGGCAAATGC TGCAGGATAG GGTGACCGAG GAGGTTCCCC TTGACCCCCT GATGAATCGG ACCGGGAACG TGTGGCATGT CTTCATCGAA AAAACATGAC CCCGTTTACG ACGTCCTATC CCACTGGCTC CTCCAAGGGG AACTGGGGGA CTACTTAGCC TGGCCCTTGC ACACCGTACA GAAGTAGCTT Exon 2 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 201 GGCGAGCTGC ACAACATGCT TTACGGGTAC AGGTTCGACG GCACCTTTGC TCCTCACTGC GGGCACTACC TTGATGTTTC CAATGTCGTG GTGGATCCTT CCGCTCGACG TGTTGTACGA AATGCCCATG TCCAAGCTGC CGTGGAAACG AGGAGTGACG CCCGTGATGG AACTACAAAG GTTACAGCAC CACCTAGGAA Exon 2 Exon 3 ~~~~~~~~ ~~ 301 ATGCTAAGGT GATCATACAT TAGCTTTACC TGCATCTTGG TATTTACAGT AGAAATTGTT ACGAGGACGC TTATTTGCTG CCTTTTGTGT TGCTCCAGGC TACGATTCCA CTAGTATGTA ATCGAAATGG ACGTAGAACC ATAAATGTCA TCTTTAACAA TGCTCCTGCG AATAAACGAC GGAAAACACA ACGAGGTCCG Exon 3 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 401 AGTGATAAGC CGAGGGGAGT ATGGTGTTCC AGCGCGTGGT AACAATTGCT GGCCTCAGAT GGCTGGCATG ATCCCTCTTC CATATAGCAC GGTATGCCTG TCACTATTCG GCTCCCCTCA TACCACAAGG TCGCGCACCA TTGTTAACGA CCGGAGTCTA CCGACCGTAC TAGGGAGAAG GTATATCGTG CCATACGGAC 501 ATTGCTGAAA ATATCGGCTG CATTTGTTTC TCTCTTTTTC TCATATTTTT CTCCTGTCTT TCACTTGTAC TACGTTGCCT CAGACAGTCA TGATCAAAGA TAACGACTTT TATAGCCGAC GTAAACAAAG AGAGAAAAAG AGTATAAAAA GAGGACAGAA AGTGAACATG ATGCAACGGA GTCTGTCAGT ACTAGTTTCT 601 GAGCAGTGTT ATTAGACATT TGTAGTTGTC TGCTGACTTT GACGAAAACT TGTAATTTAT GTTGTTAAAG GTCCTTGAAT CATATTTTTT TATACTATTA CTCGTCACAA TAATCTGTAA ACATCAACAG ACGACTGAAA CTGCTTTTGA ACATTAAATA CAACAATTTC CAGGAACTTA GTATAAAAAA ATATGATAAT Exon 4 ~~ 701 TGTTTGCAAG TGGAAGTGAA GTGAAATTGC ATCTAGTATT TGTTGTTGTT GTCTTAGCCG TTTAATTGGA CATGCAGTAA AAAGGTTTGC ATCTGCAGTT ACAAACGTTC ACCTTCACTT CACTTTAACG TAGATCATAA ACAACAACAA CAGAATCGGC AAATTAACCT GTACGTCATT TTTCCAAACG TAGACGTCAA Exon 4 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 801 TGATTGGGAA GGCGACCTAC CTCTAAGATA TCCTCAAAAG GACCTGGTAA TATATGAGAT GCACTTGCGT GGATTCACGA AGCATGATTC AAGCAATGTA ACTAACCCTT CCGCTGGATG GAGATTCTAT AGGAGTTTTC CTGGACCATT ATATACTCTA CGTGAACGCA CCTAAGTGCT TCGTACTAAG TTCGTTACAT Exon 4 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 901 GAACATCCGG GTACTTTCAT TGGAGCTGTG TCGAAGCTTG ACTATTTGAA GGTACAGTTG TACTTGCTGA TTACATAGGA TAATTTTTTA AAGAAAGCTA CTTGTAGGCC CATGAAAGTA ACCTCGACAC AGCTTCGAAC TGATAAACTT CCATGTCAAC ATGAACGACT AATGTATCCT ATTAAAAAAT TTCTTTCGAT 1001 CATATTAGCC AGAATTTGGG TTATTACAAA AACTACTGCT ATAGCAGTTA CATGCTCATT ATCGAGGAGA TGCTCACACG CATCTTATTT GGATTTAATA GTATAATCGG TCTTAAACCC AATAATGTTT TTGATGACGA TATCGTCAAT GTACGAGTAA TAGCTCCTCT ACGAGTGTGC GTAGAATAAA CCTAAATTAT G->A (ApA-2164) ~ Exon 5 ~~~~~~~~~~~~~~ 1101 CCCAATTCTG TAATCATGAC TAAATATGTT TTCCCAGATC TGCTTATGAA TTCCGTATTA TTTAATATTG GACTGTTCCC TCTACAGGAG CTTGGAGTTA GGGTTAAGAC ATTAGTACTG ATTTATACAA AAGGGTCTAG ACGAATACTT AAGGCATAAT AAATTATAAC CTGACAAGGG AGATGTCCTC GAACCTCAAT Exon 5 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1201 ATTGTATTGA ATTAATGCCC TGCCATGAGT TCAACGAGCT GGAGTACTCA ACCTCTTCTT CCAAGTAAGG ACTTGAATTT AGTATTAGCC TGCCAGCACT TAACATAACT TAATTACGGG ACGGTACTCA AGTTGCTCGA CCTCATGAGT TGGAGAAGAA GGTTCATTCC TGAACTTAAA TCATAATCGG ACGGTCGTGA 1301 GTTGGAGTGA GAGTTCATAC ACATTTTGTG CCTGCATAAC TGATATTTGT TCAAACTATT TTTTAGCAGT CACTCAACAG TTATATATAT ATGATCTATA CAACCTCACT CTCAAGTATG TGTAAAACAC GGACGTATTG ACTATAAACA AGTTTGATAA AAAATCGTCA GTGAGTTGTC AATATATATA TACTAGATAT 1401 CCGGCTGCTG CTAATGATGT TAATATTTCG CAAGTACCTA AGCTAGATTT TTCTCCATGA AACATCAATC CATAATTGAA ATTGGTCACA ACAGTTGAAT GGCCGACGAC GATTACTACA ATTATAAAGC GTTCATGGAT TCGATCTAAA AAGAGGTACT TTGTAGTTAG GTATTAACTT TAACCAGTGT TGTCAACTTA 1501 AGTTGATAGC TGAAAATGAA ATCCAGCATG CTACTGTCTT GCCATCTCCA GACTTGCTAA CATGAATTTT GTCTGCCTAC CTGTCATTTG TACCAACGTT TCAACTATCG ACTTTTACTT TAGGTCGTAC GATGACAGAA CGGTAGAGGT CTGAACGATT GTACTTAAAA CAGACGGATG GACAGTAAAC ATGGTTGCAA 1601 CCCAATTGCC CTCTCATTAT TCGTGTGTAC CATGCATATG TGTTTTAACA TGATTATTGT TGGCTATATT TCTCTTTGGA AACATGACCA ATTTATCACT GGGTTAACGG GAGAGTAATA AGCACACATG GTACGTATAC ACAAAATTGT ACTAATAACA ACCGATATAA AGAGAAACCT TTGTACTGGT TAAATAGTGA Exon 6 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1701 GTTTTGTATA AACTGCTTGT TTTCTTATCA GGATGAACTT TTGGGGATAT TCTACCATAA ACTTCTTTTC ACCAATGACA AGATACACAT CAGGCGGGAT CAAAACATAT TTGACGAACA AAAGAATAGT CCTACTTGAA AACCCCTATA AGATGGTATT TGAAGAAAAG TGGTTACTGT TCTATGTGTA GTCCGCCCTA Exon 6 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1801 AAAAAACTGT GGGCGTGATG CCATAAATGA GTTCAAAACT TTTGTAAGAG AGGCTCACAA ACGGGGAATT GAGGTAAGCA AGTCGTATGA GTTAGTTGCT TTTTTTGACA CCCGCACTAC GGTATTTACT CAAGTTTTGA AAACATTCTC TCCGAGTGTT TGCCCCTTAA CTCCATTCGT TCAGCATACT CAATCAACGA Exon 7 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 1901 CCTTTTGAAC TTATCAATTT GATGCGAAGA AATGTTACTG TTAGGTGATC CTGGATGTTG TCTTCAACCA TACAGCTGAG GGTAATGAGA ATGGTCCAAT GGAAAACTTG AATAGTTAAA CTACGCTTCT TTACAATGAC AATCCACTAG GACCTACAAC AGAAGTTGGT ATGTCGACTC CCATTACTCT TACCAGGTTA Exon 7 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 2001 ATTATCATTT AAGGGGGTCG ATAATACTAC ATACTATATG CTTGCACCCA AGGTGACAGA TCTTTCTTGC TGCATAATTG TTCTTTCATA GATGTATAGA TAATAGTAAA TTCCCCCAGC TATTATGATG TATGATATAC GAACGTGGGT TCCACTGTCT AGAAAGAACG ACGTATTAAC AAGAAAGTAT CTACATATCT Exon 8 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 2101 GTATAGATGT GTTATGTAGT AGTTCTTTTT CAAGGGGATT ATGTTCATGC AGGGAGAGTT TTATAACTAT TCTGGCTGTG GGAATACCTT CAACTGTAAT CATATCTACA CAATACATCA TCAAGAAAAA GTTCCCCTAA TACAAGTACG TCCCTCTCAA AATATTGATA AGACCGACAC CCTTATGGAA GTTGACATTA Exon 8 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 2201 CATCCTGTGG TTCGTCAATT CATTGTAGAT TGTTTAAGGT ACAGATATAC ATTTTACTTC TAGAACTACT TTTCATTTCT TTCGCTGCTT GTCATTTTGA GTAGGACACC AAGCAGTTAA GTAACATCTA ACAAATTCCA TGTCTATATG TAAAATGAAG ATCTTGATGA AAAGTAAAGA AAGCGACGAA CAGTAAAACT 2301 TATGATTAAT TTGCAAGCTT GTGGGGGTAA ATCTTTTGGT CAGCATATTG TATCTTTAAA TGTCACCAAT ACTAATGTCC TGGTGCTTAT TGATTTGGCA ATACTAATTA AACGTTCGAA CACCCCCATT TAGAAAACCA GTCGTATAAC ATAGAAATTT ACAGTGGTTA TGATTACAGG ACCACGAATA ACTAAACCGT Exon 9 ~~~~~~~~~~~~~~~~~~~~~~~~ 2401 TCTTCAAATT CTTTTTCTCC AGTGAAAAGG GAAAAATCTA CTGTATGTCT CGTCAACTAA TTTACTTTTA TTTTGCAGAT ACTGGGTGAC GGAAATGCAT AGAAGTTTAA GAAAAAGAGG TCACTTTTCC CTTTTTAGAT GACATACAGA GCAGTTGATT AAATGAAAAT AAAACGTCTA TGACCCACTG CCTTTACGTA G->A (ApA-1119) ~ Exon 9 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 2501 GTTGATGGTT TTCGTTTTGA TCTTGCATCC ATAATGACCA GAGGTTCCAG GTAATTTGTA TTTATTGTTT GTTTGCGTGT TGCCTTTTCA GAAGATTCTT CAACTACCAA AAGCAAAACT AGAACGTAGG TATTACTGGT CTCCAAGGTC CATTAAACAT AAATAACAAA CAAACGCACA ACGGAAAAGT CTTCTAAGAA Exon 10 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 2601 AAAAGAATGT TTCTTTTACA AGTCTGTGGG ATCCAGTTAA CGTGTATGGA GCTCCAATAG AAGGTGACAT GATCACAACA GGGACACCTC TTGTTACTCC TTTTCTTACA AAGAAAATGT TCAGACACCC TAGGTCAATT GCACATACCT CGAGGTTATC TTCCACTGTA CTAGTGTTGT CCCTGTGGAG AACAATGAGG Exon 10 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 2701 ACCACTTATT GACATGATCA GCAATGACCC AATTCTTGGA GGCGTCAAGG TACTTGTTTC ATCCAACACC TGTTGTCTGT GTGCATTCAA TTGTTTTAAT TGGTGAATAA CTGTACTAGT CGTTACTGGG TTAAGAACCT CCGCAGTTCC ATGAACAAAG TAGGTTGTGG ACAACAGACA CACGTAAGTT AACAAAATTA 2801 ATGGTAATGA TCAATTTCCC AATGCTGATA AGGAAAAAAA AATGCAAGTA GCTCTCTTTA TCTGCTTCTT GTGAGTTATG CTAAACATGT AGATACTATA TACCATTACT AGTTAAAGGG TTACGACTAT TCCTTTTTTT TTACGTTCAT CGAGAGAAAT AGACGAAGAA CACTCAATAC GATTTGTACA TCTATGATAT Exon 11 ~~~~~~~~~~~~~~~~~~~~~~~~~~ 2901 TTTCAACTGT ATATACTTGA CATATTATTG CTTCCTTTGG AGGCTCTCTT ATTCCTTTCC CCCGTTGCAA TTATAGCTCA TTGCTGAAGC ATGGGATGCA AAAGTTGACA TATATGAACT GTATAATAAC GAAGGAAACC TCCGAGAGAA TAAGGAAAGG GGGCAACGTT AATATCGAGT AACGACTTCG TACCCTACGT Exon 11 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 3001 GGAGGCCTCT ATCAAGTAGG TCAATTCCCT CACTGGAATG TTTGGTCTGA GTGGAATGGG AAGGTAAGCT ACCTGTTAAA AGTTTGATTG GCAAATACTG CCTCCGGAGA TAGTTCATCC AGTTAAGGGA GTGACCTTAC AAACCAGACT CACCTTACCC TTCCATTCGA TGGACAATTT TCAAACTAAC CGTTTATGAC 3101 ATAGAAATAT AACTTATATT TGTGACATAT ATAGATAAAG CAAAGTAATA CGCATTCCAC CTGAACTTTA AAGGGGCACG CAGAATTATC CCGCATCTGT TATCTTTATA TTGAATATAA ACACTGTATA TATCTATTTC GTTTCATTAT GCGTAAGGTG GACTTGAAAT TTCCCCGTGC GTCTTAATAG GGCGTAGACA 3201 CTACAAGAAT GATAACACAT GTGCTGAATA GTGAAGTACT ACTTGTCAAA TGTCTGAATG AATGCACTAA CTCTTGTGGG TGTCAACCGA GCAAGAAATA GATGTTCTTA CTATTGTGTA CACGACTTAT CACTTCATGA TGAACAGTTT ACAGACTTAC TTACGTGATT GAGAACACCC ACAGTTGGCT CGTTCTTTAT 3301 TTTGAGTTTT CTGCAAGAAA TTGTTCATGT TGTGCTGTAT TATACTCCCT CCGTCCGAAA TTACTTGTCG GAGAAATGGA TGTATCTAGA CGTATTTTAG AAACTCAAAA GACGTTCTTT AACAAGTACA ACACGACATA ATATGAGGGA GGCAGGCTTT AATGAACAGC CTCTTTACCT ACATAGATCT GCATAAAATC 3401 TTCTAGATAC ATCCATTTTT ATCCATTTCT GCAACAAGTA GTTCCGGATG GAGGGAGTAT CATTTAACAA ATATATGCAT GTTCGAAGTA AATCCCCACG AAGATCTATG TAGGTAAAAA TAGGTAAAGA CGTTGTTCAT CAAGGCCTAC CTCCCTCATA GTAAATTGTT TATATACGTA CAAGCTTCAT TTAGGGGTGC 3501 AATAAGCACA GAAGACGATA TTGCTTTTTG ACTTGCAACA CCTAACCCTC CGTCCGAAAT TACTTGTCGG AGAAATGGAT GTATCTAGAC GTATTTTAGT TTATTCGTGT CTTCTGCTAT AACGAAAAAC TGAACGTTGT GGATTGGGAG GCAGGCTTTA ATGAACAGCC TCTTTACCTA CATAGATCTG CATAAAATCA 3601 TCTAGATACA TCCATTTTTA TCCATTTCTG CAACAAGTAG TTCCGGATGG AGGGAGTATC ATTTAACAAA TATATGCATG TTCGAAGTAA ATCCCCACGA AGATCTATGT AGGTAAAAAT AGGTAAAGAC GTTGTTCATC AAGGCCTACC TCCCTCATAG TAAATTGTTT ATATACGTAC AAGCTTCATT TAGGGGTGCT 3701 ATAAGCACAG AAGACGATAT TGCTTTTTGA CTTGCAACAC CTAAACCTCA TTGTTTTCTC CTAGGATTTT GGGTGTTTGA AGCAAGCAGC TGGATGATAT TATTCGTGTC TTCTGCTATA ACGAAAAACT GAACGTTGTG GATTTGGAGT AACAAAAGAG GATCCTAAAA CCCACAAACT TCGTTCGTCG ACCTACTATA 3801 TTAATTTACC TTTACCTTTA TTTGTAGCTT GATTTGAGGG TGCGACAAAG GTTTTCGCTT AGTAGTATTT TGTAAATTAT TATAGTTTAT ATATATACTC AATTAAATGG AAATGGAAAT AAACATCGAA CTAAACTCCC ACGCTGTTTC CAAAAGCGAA TCATCATAAA ACATTTAATA ATATCAAATA TATATATGAG 3901 CTCATTTGGG CACTTCCGTA CTGGTCCCAT AGAAAATAAA AATGGAATTG TGAATTCTGG GTGTCTGGCC AATAATTATT GACAACACTG CTGCGCATTT GAGTAAACCC GTGAAGGCAT GACCAGGGTA TCTTTTATTT TTACCTTAAC ACTTAAGACC CACAGACCGG TTATTAATAA CTGTTGTGAC GACGCGTAAA 4001 GGTTTTTATC AGGGAATGAA AAATTGAAAT CGGTAAGAAA CATTGCGATA TTAAGCTTGT ACTTCCTCCG TTCCTAAATA TAAGTATTTT TAGAGATTTC CCAAAAATAG TCCCTTACTT TTTAACTTTA GCCATTCTTT GTAACGCTAT AATTCGAACA TGAAGGAGGC AAGGATTTAT ATTCATAAAA ATCTCTAAAG 4101 TATATGGACT ACATACGGAT GTATATAGAC GTATTTTAGA GTGTAGATTC ACTCATTTTG CTTTGTATGT AGTCCATATT AGAATCTCTA AAAAGACTTA ATATACCTGA TGTATGCCTA CATATATCTG CATAAAATCT CACATCTAAG TGAGTAAAAC GAAACATACA TCAGGTATAA TCTTAGAGAT TTTTCTGAAT 4201 TATTTAGGAA CGGAGGGAGT ATATGCTAAT GCTGGTGGAT CTTTAAGAGG GAACATATGA TCTTGTGCAT CCATTTCAAC TAAACAAATA TGTTGCACAT ATAAATCCTT GCCTCCCTCA TATACGATTA CGACCACCTA GAAATTCTCC CTTGTATACT AGAACACGTA GGTAAAGTTG ATTTGTTTAT ACAACGTGTA Exon 12 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 4301 CTCCCACGTC ACTTACTAGC TATTTCATCC AAGTACTAAC TTGTGTGGTT GTTTCCTCAG TACCGGGACA TTGTGCGTCA ATTCATTAAA GGCACTGATG GAGGGTGCAG TGAATGATCG ATAAAGTAGG TTCATGATTG AACACACCAA CAAAGGAGTC ATGGCCCTGT AACACGCAGT TAAGTAATTT CCGTGACTAC Exon 12 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 4401 GATTTGCTGG TGGTTTTGCC GAATGTCTTT GTGGAAGTCC ACACCTATAC CAGGTAAGTT GTGGCAATAC TTGTAAATGA GTTGAGTGAA TGTCACCTGG CTAAACGACC ACCAAAACGG CTTACAGAAA CACCTTCAGG TGTGGATATG GTCCATTCAA CACCGTTATG AACATTTACT CAACTCACTT ACAGTGGACC 4501 ATTTTTTATA TATACCACAT GATGATACAC ATCTAAATAT ATAACAATCA TAGTGTATGC ATATGCATTT GGCTAAGAAG TATTAGTGTA TACACTAGTG TAAAAAATAT ATATGGTGTA CTACTATGTG TAGATTTATA TATTGTTAGT ATCACATACG TATACGTAAA CCGATTCTTC ATAATCACAT ATGTGATCAC 4601 CTATATATAG GTTTTAACAC CCAACTTGCC AATGAAGGAA CATAGGGCTT TCTAGTTATC TTATTTATTT GTCCGGTGAA TAATCCACTG AAAAATTCCA GATATATATC CAAAATTGTG GGTTGAACGG TTACTTCCTT GTATCCCGAA AGATCAATAG AATAAATAAA CAGGCCACTT ATTAGGTGAC TTTTTAAGGT 4701 GCCATGTCAT TTTTTAGGGG GGGAGAAGAA ACTATATTGA TTTGCCCCCC TAAAAGAAGC CATCTCAGAA TTCATAGGTA AGTTGCTTTT CTGTAAAGAA CGGTACAGTA AAAAATCCCC CCCTCTTCTT TGATATAACT AAACGGGGGG ATTTTCTTCG GTAGAGTCTT AAGTATCCAT TCAACGAAAA GACATTTCTT 4801 AGGAAAACGA CTTCATACTT TCTATCGGTG CTAACTTAGC TCGATGTATA TTTGTAAGAT GAATGCCAAA TTTAATTTGT CGGATAATTT GATCTGTTAT TCCTTTTGCT GAAGTATGAA AGATAGCCAC GATTGAATCG AGCTACATAT AAACATTCTA CTTACGGTTT AAATTAAACA GCCTATTAAA CTAGACAATA 4901 TCACATACTT TCTAGTTATC TTATTTATTT GTCCGGTGAA TAATCCACTG AAAAATTCCA GCCATGTCAT TTTTTAGGGG GGGAGAAGAA ACTATATTGA AGTGTATGAA AGATCAATAG AATAAATAAA CAGGCCACTT ATTAGGTGAC TTTTTAAGGT CGGTACAGTA AAAAATCCCC CCCTCTTCTT TGATATAACT 5001 TTTGCCCCCC TAAAAGAAGC CATCTCAGAA TTCATAGGTA AGTTGCTTTT CTGTAAAGAA AGGAAAACGA CTTCATACTT TCTATCGGTG CTAACTTAGC AAACGGGGGG ATTTTCTTCG GTAGAGTCTT AAGTATCCAT TCAACGAAAA GACATTTCTT TCCTTTTGCT GAAGTATGAA AGATAGCCAC GATTGAATCG 5101 TCGATGTATA TTTGTAAGAT GAATGCCAAA TTTAATTTGT CGGATAATTT GATCTGTTAT TCACAAATTT CTATTTGGTT TCTCTAGAAA TCAAACCAGT AGCTACATAT AAACATTCTA CTTACGGTTT AAATTAAACA GCCTATTAAA CTAGACAATA AGTGTTTAAA GATAAACCAA AGAGATCTTT AGTTTGGTCA Exon 13 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 5201 AACTTGTTAT TGGCACTGCA ACTTCTTATT GATTAATCAG GCAGGAGGAA GGAAACCTTG GCACAGTATC AACTTTGTAT GTGCACATGA TGGATTTACA TTGAACAATA ACCGTGACGT TGAAGAATAA CTAATTAGTC CGTCCTCCTT CCTTTGGAAC CGTGTCATAG TTGAAACATA CACGTGTACT ACCTAAATGT Exon 13 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 5301 CTGGCTGATT TGGTAACATA TAATAAGAAG TACAATTTAC CAAATGGGGA GAACAACAGA GATGGAGAAA ATCACAATCT TAGCTGGAAT TGTGGGGAGG GACCGACTAA ACCATTGTAT ATTATTCTTC ATGTTAAATG GTTTACCCCT CTTGTTGTCT CTACCTCTTT TAGTGTTAGA ATCGACCTTA ACACCCCTCC 5401 TAATTCTGAA CTCTCCTTTT TTTTTTTTTG AAATTTTCAT GCTTTACATA ATAGTTGAAT GGCTGACAAA TGTCGTTGTA TGGTTCTCTC TCTACCTAAA ATTAAGACTT GAGAGGAAAA AAAAAAAAAC TTTAAAAGTA CGAAATGTAT TATCAACTTA CCGACTGTTT ACAGCAACAT ACCAAGAGAG AGATGGATTT 5501 CCGTTAAGGC AGTAAGAGTT TCCCTACAAG ATCTCTTTGT TCGTATAATT ATATTTTCTA GAGAAAAGTT GCCTTCAATT TTGTGCACAC GGCAGTACAG GGCAATTCCG TCATTCTCAA AGGGATGTTC TAGAGAAACA AGCATATTAA TATAAAAGAT CTCTTTTCAA CGGAAGTTAA AACACGTGTG CCGTCATGTC 5601 GAATTGTGGT TATAAATATT GATACAGGCT GACCACCGTT ACTAATTTGG GAACAATAAG CACATTTTTT TTAATAGCAA AGGCATCACC CTGGTTCCAT CTTAACACCA ATATTTATAA CTATGTCCGA CTGGTGGCAA TGATTAAACC CTTGTTATTC GTGTAAAAAA AATTATCGTT TCCGTAGTGG GACCAAGGTA 5701 TTCCAACGAA ATCACAGTAT CCGAACCATA AGTTTTACAA GTATGCGTAG AGAGAAATAA AGTATCAACC CGGCAGAAAC AGTTGTTTCA GGCGCAAAGA AAGGTTGCTT TAGTGTCATA GGCTTGGTAT TCAAAATGTT CATACGCATC TCTCTTTATT TCATAGTTGG GCCGTCTTTG TCAACAAAGT CCGCGTTTCT 5801 GAAAAGGAAA CGATATGCTC TATTACATCA ACCTTTTAGA ATTTAGGGAC GACCAGCATC ATCCCATCTT CAATCAACTG GAGCGAGGTC ACCTCCAATC CTTTTCCTTT GCTATACGAG ATAATGTAGT TGGAAAATCT TAAATCCCTG CTGGTCGTAG TAGGGTAGAA GTTAGTTGAC CTCGCTCCAG TGGAGGTTAG 5901 TTCTCAGCAG CCTCAGAGTG GTTACCTCCC AAGCAAGTGC ATCCGCATCC ATCATCTGAG GGTTGGGCAC ATGCCATGAG CACAATCACC TGAATTTGAT AAGAGTCGTC GGAGTCTCAC CAATGGAGGG TTCGTTCACG TAGGCGTAGG TAGTAGACTC CCAACCCGTG TACGGTACTC GTGTTAGTGG ACTTAAACTA 6001 GAATTTTCCT CTGTTTACCT TGCAGCAGAC CCCTGCCGTA TAAATGGTTT TAAATGACAG CATGTTCTTT CAGTTTGGAG CAAAATTTGT GCAATTGCAA CTTAAAAGGA GACAAATGGA ACGTCGTCTG GGGACGGCAT ATTTACCAAA ATTTACTGTC GTACAAGAAA GTCAAACCTC GTTTTAAACA CGTTAACGTT Exon 14 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 6101 AGAAGCTTTA GAATCATGTG TAACATGCAC TTACATTTCA TGTGAACAAT ATAGGAAGGA GAATTCGCAA GATTGTCTGT CAAAAGATTG AGGAAGAGGC TCTTCGAAAT CTTAGTACAC ATTGTACGTG AATGTAAAGT ACACTTGTTA TATCCTTCCT CTTAAGCGTT CTAACAGACA GTTTTCTAAC TCCTTCTCCG Exon 14 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 6201 AGATGCGCAA TTTCTTTGTT TGTCTCATGG TTTCTCAAGT AAGACTTATA TCTGATCTCT TTAATTTTTG AGATTGCCTG TTTTTCACAA TGGCATGTGT TCTACGCGTT AAAGAAACAA ACAGAGTACC AAAGAGTTCA TTCTGAATAT AGACTAGAGA AATTAAAAAC TCTAACGGAC AAAAAGTGTT ACCGTACACA 6301 TGTCAGGCGA AACATCCAAT CCCAATATTA ATAGAGCCAA CATGAAGGGA TTGCTTATCT GAGATATCTG CCAAAGTTAA ATTCTTACAT TCACCTTCTT ACAGTCCGCT TTGTAGGTTA GGGTTATAAT TATCTCGGTT GTACTTCCCT AACGAATAGA CTCTATAGAC GGTTTCAATT TAAGAATGTA AGTGGAAGAA Exon 15 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 6401 CAGTATTTCA GACCTTCTAA GCATTTTCAT TTTTTTTGAA TTGTTAGGGA GTTCCAATGT TCTACATGGG TGATGAATAT GGCCACACAA AAGGGGGCAA GTCATAAAGT CTGGAAGATT CGTAAAAGTA AAAAAAACTT AACAATCCCT CAAGGTTACA AGATGTACCC ACTACTTATA CCGGTGTGTT TTCCCCCGTT Exon 15 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 6501 CAACAATACA TACTGCCATG ATTCTTATGT CAGTACAATT TGGTCACATA TTGTTGTTCT AAGTAACTAT CTTCAAATCT TTGCATTCAT CCGTCATGGC GTTGTTATGT ATGACGGTAC TAAGAATACA GTCATGTTAA ACCAGTGTAT AACAACAAGA TTCATTGATA GAAGTTTAGA AACGTAAGTA GGCAGTACCG Exon 16 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 6601 TCTTCTGTAG GTCAATTATT TTCGCTGGGA TAAAAAAGAA CAATACTCTG AGTTGCACCG ATTCTGCTGC CTCATGACCA AATTCCGCAA GTAAGTATTT AGAAGACATC CAGTTAATAA AAGCGACCCT ATTTTTTCTT GTTATGAGAC TCAACGTGGC TAAGACGACG GAGTACTGGT TTAAGGCGTT CATTCATAAA 6701 CCGTTGAATA ATTTCTGTGT AGAACCACTG AAGGTGCCTC CAAACGCTAA GCAAGAAGCA ATGTCAATTT CACACCCTAA TCAAGTTGGT GTTGTCTATT GGCAACTTAT TAAAGACACA TCTTGGTGAC TTCCACGGAG GTTTGCGATT CGTTCTTCGT TACAGTTAAA GTGTGGGATT AGTTCAACCA CAACAGATAA Exon 17 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 6801 TGTGTATTTG ATCTGCTGCA CTGTAGGGAG TGCGAGGGTC TTGGCCTTGA GGACTTTCCA ACGGCCAAAC GGCTGCAGTG GCATGGTCAT CAGCCTGGGA ACACATAAAC TAGACGACGT GACATCCCTC ACGCTCCCAG AACCGGAACT CCTGAAAGGT TGCCGGTTTG CCGACGTCAC CGTACCAGTA GTCGGACCCT Exon 17 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 6901 AGCCTGATTG GTCTGAGAAT AGCCGATTCG TTGCCTTTTC CATGGTACTC ATATAGTTCT GACACTTCAC TATAGTTGTT TTAAAAAAGA AAATTTAACT TCGGACTAAC CAGACTCTTA TCGGCTAAGC AACGGAAAAG GTACCATGAG TATATCAAGA CTGTGAAGTG ATATCAACAA AATTTTTTCT TTTAAATTGA Exon 18 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 7001 CAAAAGTAAA TTATGGAGAG TTTTAGAAGT AACAAATATC TTTATGTATC TCATCACAGA AAGATGAAAG ACAGGGCGAG ATCTATGTGG CCTTCAACAC GTTTTCATTT AATACCTCTC AAAATCTTCA TTGTTTATAG AAATACATAG AGTAGTGTCT TTCTACTTTC TGTCCCGCTC TAGATACACC GGAAGTTGTG Exon 18 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 7101 CAGCCACTTA CCGGCCGTTG TTGAGCTCCC AGAGCGCGCA GGGCGCCGGN NNNNGGGAAC CGGTGGTGGA CACAGGCAAG CCAGCACCAT ACGACTTCCT GTCGGTGAAT GGCCGGCAAC AACTCGAGGG TCTCGCGCGT CCCGCGGCCN NNNNCCCTTG GCCACCACCT GTGTCCGTTC GGTCGTGGTA TGCTGAAGGA Exon 18 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ 7201 CACCGACGAC TTACCTGATC GCGCTCTCAC CATACACCAG TTCTCGCATT TCCTCTACTC CAACCTCTAC CCCATGCTCA GCTACTCATC GGTCATCCTA GTGGCTGCTG AATGGACTAG CGCGAGAGTG GTATGTGGTC AAGAGCGTAA AGGAGATGAG GTTGGAGATG GGGTACGAGT CGATGAGTAG CCAGTAGGAT Exon 18 ~~~~~~~~~~~~~~~~~~~ 7301 GTATTGCGCC CTGATGTTTG AGAGACCAAT CATAACGCGG GACTACAAAC TCTCTGGTTA