INPI-France/Brevets-Francais-2024-Chunked huggingface dataset:
SEQ ID NO 320 LI-2487. 1 30 sp) Q45460pPBABACSUCHOL) NE TRANSPORT ATP-BINDING PROTEIN OPUBA pir rG69669 choline ABC transporter (ATP-binding protein) opuBABacillus subtilis gb) AAC14356. 11 (AF008930) ATPase [Bacillus subtilis] emblCAB15378 11 (Z99121) choline ABC tr SEQ ID N 321 LI-3180. 1 No Hits found SEQ ID ? 322 LI-2997. 1 44 emblCAB53856 11 (AJ242593) gp66 [Bacteriophage AU18] Length = 144 SEQ ID N'323 LI-6045. 1 44 embICAB53856. 11 (AJ242593) gp66 [Bacteriophage AU18] Length = 144 SEQ ID N 324 LI-1517. 1 40 pilla28298 myosin heavy chain beta, cardiac muscle-golden hamster (fragment) emb1CM30256. 11 (X07273) beta-myosin heavy chain (974 Axa), S2 fragment and LMM region [Mesocricetus auratus] Length = 974" SEQ ID ? 325 LI-6006. 2 SEQ ID N'326 LI-3335. 1 34 gblAAF66771 11AF147806-35 (AF1 47806) major tegument protein [Gallid herpesvirus 2] Length = 3325 SEQ ID NO 327 LI-51. 1 No Hits found SEQ ID NO 328 LI-1931. 1 No Hits found SEQ ID N"329 LI-4521. 1 No Hits found SEQ ID N 330 LI-6028 1 51 spIP45911jYQAN~BACSU HYPOTHETICAL 16. 1 KD PROTEIN IN SPOIIICCWLA INTERGENIC REGION pir rE69945 hypothetical protein yqaN-Bacillus subtilis dbjlBAA06928 11 (D32216) ORF39 [Bacillus subtilis] dbj ! BAA12389. 11 (D84432) YqaN [Bacillus subtills] emblCAB1 SEQ ID N'331 LI-3319. 1 No Hits found SEQ ID N 332 LI-4250. 1 No Hits found SEQ ID NO 333 LI-108. 1 No Hits found SEQ ID ? 334 LI-4959. 1 41 spIP54940jYXEA~BACSU HYPOTHETICAL 13. 0 KD PROTEIN IN IDH-DEOR INTERGENIC REGION PRECURSOR pirj) C70074 hypothetica ! protein yxeA-Bacillus subtilis dbjjBAA08317. 11 (D45912) yxeA [Bacillus subtilis] emblCAB15998 11 (Z99124) yxeA [Bacillus sub SEQ ID NO 335 LI-846 1 No Hrts found SEQ ID NO 336 LI-4170. 1 No Hits found SEQ ID N'337 LI-5577. 1 83 spIP459291YQBM-BACSU HYPOTHETICAL 16. 3 KD PROTEIN IN SPOIIICCWLA INTERGENIC REGION pir rH69947 phage-related protein homolog yqbM-Bacillus subtilis dbj) BAA06945. 11 (D32216) ORF71 [Bacillus subtilis] dbjBAA12408 1 (D84432) YqbM [Bacillus subtilis] SEQ ID N 338 LI-779. 1 40p ! rF69168 hypothettcal protem MTH520-Methanobactenum thermoautotrophicum (strain ! nDe ! taH) gbAAB85026. 1HAE000835) unknown [Methanobactenum thermoautotrophicum] Length = 104 SEQ ID ? 339 LI-2822. 1 No Hits found SEQ ID DN 340 LI-2931. 1 83 emblCAB53814 11 (AJ242593) gp28 [Bacter ! ophageA118] Length = 149 SEQ ID ? 341 LI-2976 1 No Hits found SEQ ID ? 342 LI-3835. 1 36 emblCAB57639 11 (Y18930) hypothetical protein [Sulfolobus solfataricus] Length = 106
SEQ ID N 343 LI-3613. 1 No Hits found SEQ ID N'344 LI-3988. 1 51 embICAB53821. Il (AJ242593) gp35 [Bacteriophage AU 8] Length = 163 SEQ ID No 345 LI-2287. 1 No Hits found SEQ ID N 346 LI-338. 1 No Hits found SEQ ID N 347 LI-4098. 1 25 pirll140868 hypothetical protein 3 nanH region-Clostridium perfringens embICAA60798. 11 (X87369) ORF3 [Clostridium perfringens Length = 265 SEQ ID No 348 LI-1716. 1 No Hits found SEQ ID N"349 LI-6063. 1 No Hits found SEQ ID N"350 LI-1117. 1 No Hits found SEQ ID ? 351 L !-4137. 1No Hits found SEQ ID No 352 LI-2778. 1 33 gblAAB60026. 11 (UO9422) ORF7 [Enterococcus faeca ! ! s] prf) j2114402U ORF 7 [Enterococcus faecalis] Length = 157 SEQ ID ? 353 LI-2783. 1 47gblAAF41678. 11 (AE002479) transcriptional regulator, MerR family [Neisseria meningitidis MC58] emb1CAB84745. 11 (AL 162756) putative transcriptional regulator [Neisseria meningitidis] Length = 135 SEQ ID N 354 LI-3846 1 No Hits found SEQ ID ? 355 U-929. 1 No Hits found SEQ ID N'356 LI-664. 1 No Hits found SEQ ID NO 357 LI-3625 1 51 plrllB70030 conserved hypothetical protem yvbK-Bacillus subtilis embCAB15394. 11 (Z99121) similar to hypothetical proteins from B. subtilis [Bacillus subtihs] Length = 155 SEQ ID N 358 LI-4119. 1 No Hits found SEQ ID N 359 LI-4479. 1 No Hits found SEQ ID N 360 LI-2939. 1 No Hits found SEQ ID N 361 LI-4012. 1 52 dbjlBAA97823 11 (AB044554) orf 16 staphylococcus aureus prophage ph ! PV83] Length = 159 SEQ ID N"362 LI-5553. 1 No Hits found SEQ ID N'363 LI-5583. 1 50 spIP5433OIXKDJ-BACSU PHAGE-LIKE ELEMENT PBSX PROTEIN XKDJ pirllB69732 PBSX prophage ORF xkdJ-Bacillus subtilis emb) CAA94065. 11 (Z70177) homologous to yqbJ of the skin element [Bacillus subtilis] emblCAB13121 11 (Z9911 0) PBSX prophage [Bacillus subtil SEQ ID N 364 LI-5612 2 SEQ ID N 365 LI-4016. 1 49 gblMC97922 11 (AF077306) gp151 [Streptococcus thermophilus bacteriophage Sf119] gbIMD440721IAF115102~31 (AF115102) orf151 gp streptococcus thermophilus bacteriophage Sfi19] Length = 151 SEQ ID N 366 LI-4193. 1 78 emblCAA63529 11 (X92946) transposase [Lactococcus lactis] Length 228 SEQ ID ? 367 LI-2609. 1 26 pirF72598 hypothetical protem APE1254-Aeropyrum pernix (strain K1) dbjlBM80244 11 (AP000061) 109aa long hypothehcal protem [Aeropyrum pernix] Length = 109 SEQ ID ? 368 LI-2940 1 No Hits found SEQ ID N 369 LI-4459. 1 No Hlts found SEQ ID N 370 LI-5315 1 69 sp066911 ! UVRAAQUAE EXCINUCLEASE ABC SUBUNIT A pirlIC70360 repair excision nuclease subun ! t A-Aqu ! fex aeohcus gbjAAC06874. 1 [ (AE000702) repair excision nuclease subunit A [Aquifex aeolicus] Length 926
SEQ ID ? 371 LI-5576. 1 65 spIP45930IYQBN~BACSU HYPOTHETICAL 17. 1 KD PROTEIN IN SPOIIICCWLA INTERGENIC REGION pirlIA69948 phage-related protein homolog yqbN-Bacillus subtilis dbj) BAA06946. 11 (D32216) ORF55 bacillus subtilis] dbj) BAA12410. 11 (D84432) YqbN bacillus subtilis] SEQ ID N 372 LI-5578. 1 No Hits found SEQ ID N 373 LI-2967. 1 No Hits found SEQ ID N'374 LI-2836. 1 38 pirlIH72608 hypothetical protein APE1334-Aeropyrum pernix (strain K1) dbjlBAA80326 11 (AP000061) 211aa long hypothetical protein [Aeropyrum pernix] Length = 211 SEQ ID ? 375 LI-3370. 1 No Hits found SEQ ID N'376 LI-5584. 1 70 spIP459251YQBI-BACSU HYPOTHETICAL 19. 9 KD PROTEIN IN SPOIIICCWLA INTERGENIC REGION pill069947 phage-related protein homolog yqbl - Bacillus subtlhs dbj1BM06941. 11 (032216) ORF67 [Bacillus subtilis] dbj1BM12404. 11 (084432) Yqbl [Bacillus subtilis] SEQ ID ? 377 LI-5801 1 67 gblAAF04740. 11 (AF102169) multidrug resistance-like protein [Listeria monocytogenes] Length = 228 SEQ ID NO 378 LI-3338. 1 42 pirllT33369 hypothetical protein H02F09. 3-Caenorhabditis elegans gblMC64622 11 (AF077538) unknown [Caenorhabditis elegans] Length = 1275 SEQ ID NO 379 LI-4106. 1 65 spIQ993381'STB~BACTB INSERTION SEQUENCE IS232 PUTATIVE ATPBINDING PROTEIN pirlIB37801 IstB protein homolog-Bacillus thuringiensis gblAAA98141 11 (M38370) ORF2 [Insertion sequence IS232] Length = 250 SEQ ID NO 380 LI-4155. 1 21 plr1lF72491 hypothetical protein APE2573-Aeropyrum pernix (strain K1) dbjBAA81590. 11 (AP000064) 238aa long hypothetical protein [Aeropyrum pernix] Length = 238 SEQ ID N 381 LI-2451. 1 No Hits found SEQ ID N"382 LI-3987. 1 No Hrts found SEQ ID N 383 LI-4474. 1 No Hits found SEQ ID N 384 LI-494. 1 42 gblMF41678 11 (AE002479) transcriptional regulator, MerR family [Neisseria meningitidis MC58] embICAB84745. 11 (AL162756) putative transcriptional regulator [Neissena meningitidis] Length = 135 SEQ ID N 385 LI-2964 1 No Hits found SEQ ID N 386 LI-6202. 1 SEQ ID N'387 LI-2102 1 No Hits found SEQ ID ? 388 LI-1260. 1 No Hits found SEQ ID N 389 LI-2820. 1 94 gblAAF04738 11 (AF102167) stress protein-like protein [Listena monocytogenes] Length = 174 SEQ ID N 390 LI-3283 1 No Hlts found SEQ ID N 391 LI-3378. 1 No H) ts found SEQ ID N 392 LI-6009. 2 SEQ ID No 393 LI-624. 1 No Hits found SEQ ID N 394 LI-2969 1 No Hfts found SEQ ID N 395 LI-2999 1 No Hlts found SEQ ID ? 396 LI-4003 1 No ts found SEQ ID N 397 LI-6109 1 No Hits found
SEQ ID N 398 LI-4081. 1 61 emblCAB83893 11 (AL 162753) hypothetical protein NMA0603 [Neisseria meningitidis] Length = 182 SEQ ID N'399 LI-4696. 1 67 spIP966741YDEQ-BACSU PUTATIVE NAD (P) H OXIDOREDUCTASE YDEQ pirlIC69779 NAD (P) H oxidoreductase homolog ydeQ-Bacillus subtilis dbjjBAA19364. 11 (AB001488) PROBABLE NAD (P) H OXIDOREDUCTASE.
[Bacillus subtilis] emb) CAB12337. 11 (Z99106) similarto NAD (P) H ox SEQ ID DN 400 LI-3361. 1 87 embCAB53787. 11 (AJ242593) putative terminase small subunit [Bactenophage A118] Length = 180 SEQ ID N'401 LI-2383. 1 25 gblAAC45309. 11 (U81957) putative DNA binding protein streptococcus gordonii] Length = 122 SEQ ID N 402 LI-2787. 1 No Hits found SEQ ID N 403 LI-4184. 1 72 gblAAB91419 11 (AF037091) RepB homolog [Lactobacillus rhamnosus] Length = 172 SEQ ID N'404 LI-4150 1 89 spIP192411BINR-STAAU DNA-INVERTASE BINR (TRANSPOSON TN552) plrllS16509 DNA-invertase-Staphylococcus aureus transposon Tn552 gblAAA26640 11 (M36694) DNA invertase (ttg start codon) staphylococcus aureus] Length = 192 SEQ ID N 405 LI-1323. 1 No Hlts found SEQ ID N'406 LI-3996. 1 No Hits found SEQ ID N'407 LI-5572 1 41 pirlIS49915 extensin-like protein-maize embICAA84230. 11 (Z34465) extensinlike protein [Zea mays] prf2111476A extensin-like demain [Zea mays] Length = 1188 SEQ ID ? 408 LI-4485 1 No Hits found SEQ ID N' 409 LI-6029. 1 No Hits found SEQ ID ? 410 LI-6076. 1 35 pir rS00250 myosm heavy chain-slime mold (Dictyostelium discoideum) (fragment) Length = 160 SEQ ID No 411 LI-4309 1 No Hits found SEQ ID N'412 LI-4140 1 83 gblAAF86683. 11 (AF1 79848) unknown [Lactococcus lactis subsp. lactis] Length = 196 SEQ ID N 413 LI-6189. 2 SEQ ID NO 414 LI-1239. 1 No Hits found SEQ ID N'415 LI-4079 1 57 embICAB83894. 11 (AL162753) hypothetical protein NMA0604 [Neisseria meningitidis] Length = 187 SEQ ID N"416 LI-4046 1 38 plrllT13523 hypothetical protem 34-Bacillus phage phi-105 dbJIBM36640 11 (AB016282) ORF34 [bacteriophage phi-105] Length = 200 SEQ ID NO 417 LI-5934. 1 No Hits found SEQ ID No 418 LI-2998. 1 35 pirlIT1 3190 hypothetical protein R242-Lactobacillus phage phi-gle emblCAA66766 11 (X98106) Rorf242 [Bacteriophage phig1e] Length = 242 SEQ ID N 419 LI-304. 1 20 emblCAA49825 11 (X70360) ORF2 [Azospirillum brasilense] Length = 173 SEQ ID ? 420 LI-4945 1 No Hlts found SEQ ID N 421 LI-1552. 1 29 dbjlBAA82251 11 (AB014440) orf3 staphylococcus aureus] Length =151 SEQ ID N 422 LI-4037. 1 51 dbjIBAA97848 11 (AB044554) orf 41-phi PVL orf 5 and 6 staphylococcus aureus prophage ! PV83] Length = 194
SEQ ID N'423 LI-5108. 1 38 spIP54396jYPMB~BACSU HYPOTHETICAL 17. 9 KD PROTEIN IN DINGASPB INTERGENIC REGION pir)) F69938 hypothetical protein ypmB-Bacillus subtilis gblAAB38453. 11 (L47709) putative bacillus subt ! ! ! s] emb) CAB14154. 1j (Z99115) ypmB [Bacillus subtilis] SEQ ID W 424 LI-5561. 1 53 spIP54340IXKDU~BACSU PHAGE-LiKE ELEMENT PBSX PROTEIN XKDT pirllD69733 PBSX prophage ORF xkdU-Bacillus subtilis emb1CM94042. 11 (Z70177) homologous to yqcA of the skin element bacillus subtilisez emb1CAB13131. 11 (Z9911 0) PBSX prophage bacillus subtil SEQ ID N 425 LI-1717. 1 No Hits found SEQ ID N 426 LI-6043. 1 34 pirllT13190 hypothetical protein R242-Lactobacillus phage phi-gle emb1CAA66766. 11 (X98106) Rorf242 [Bacteriophage phig1e] Length = 242 SEQ ID N 427 LI-3740. 1 44 splP46330lYXBFBACSU HYPOTHETICAL 44. 3 KDA PROTEIN IN HTPGALDX ! NTERGEN ! C REG ! ON pirjjA70073 hypothetica ! protein yxbF-Bacillus subtilis dbjIBAA21600. 1l (AB005554) yxbF [Bacillus subtilis] embjCAB16021. 11 (Z99124) alternate gene name : yxaT bacillus SEQ ID DN 428 LI-6087. 1 49 splP397841PCFBACSU POSITIVE CONTROL FACTOR pir ! ! ! 40413 positive control factor (xre region) xpf-Bacillus subtilis embCAA84046. 11 (Z34287) ORF7 ; homology to regions 4. 1 and 4. 2 of sigma factors bacillus subtilis] emb ! CAA94057. 11 (Z70177) SEQ IDN 429 LI-2151. 1 No Hits found SEQ ID N 430 LI-4097. 1 No Hits found SEQ ID ? 431 LI-4146. 1 78gbAAB08926. 1 (U39859) invertase-enterococcal [Enterococcus faecalis] Length = 202 SEQ ID N 432 LI-1236. 1 No Hits found SEQ IDN 433 LI-3291. 1 No Hits found SEQ IDN 434 LI-4512. 1 30 pirF71011 hypothetical protein PH1388-Pyrococcus horikoshii dbjjBAA30494. 11 (AP000006) 119aa long hypothetical protein [Pyrococcus horikoshii] Length = 119 SEQ ID N'435 LI-4120. 1 32 gblAAC17959. 11 (AF022806) unknown [Pantoea citrea] Length = 208 SEQ IDN 436 LI-4223. 1 35 emblCAB88960 11 (AL353864) hypothetical protein SC8F11. 09. [Streptomyces coelicolor A3 (2)] Length = 137 SEQ IDN 437 LI-6183. 2 SEQ ID NO 438 LI-13451 43 emblCAB75242 11 (Al139075) putative periplasmic protein [Campylobacter jejunl] Length = 390 SEQ ID W 439 LI-3379 1 67 emblCAB5384111 (AJ242593) gp51 {Bacteriophage AU 8] Length =186 SEQ IDN 440 LI-5543. 1 No Hits found SEQ ID N 441 LI-6018 1 47 gblAAF43118 1) AF208055~5 (AF208055) Orf245 [bacteriophage phi31 1] gblAAF74061. 11 (AF212844) ORF245 [Lactococcus lactis] gbjAAF74095. 11 (AF212846) ORF245 [Lactococcus lactis bactenophage ut36. 1] gblMF74110 11 (AF212847) ORF245 [Lactococcus lactis bac SEQ IDN 442 LI-1951. 1 No Hits found SEQiDN 443 Li-4535. 1No Hfts found
SEQ ID N 444 LI-1171. 1 37 gblAAF36806. 11 (AF155139) VanZF [Paenibacillus popilliae] Length = 206 SEQ ID N 445 LI-1215. 1 59 pirA69898 conserved hypothetical protein yoaZ-Bacillus subtilis gb ! AAB84456 1) (AF027868) YoaZ bacillus subtilis] emb) CAB13771. 11 (Z99114) similar to hypothetical proteins from B. subtilis bacillus subtilis] Length = 210 SEQ ID N'446 LI-4153. 1 64 spIP946061ATKC-CLOAB POTASSIUM-TRANSPORTING ATPASE C CHAIN (ATP PHOSPHOHYDROLASE [POTASSIUM-TRANSPORTING] C CHAIN) gb1AAC45479. 11 (U44892) KdpC [Clostridium acetobutylicum] Length = 204 SEQ ID N 447 LI-2943. 1 No Hits found SEQ ID NO 448 LI-2942. 1 No Hits found SEQ ID N 449 LM 120. 1 35 splP310781PETPRHOCA PETP PROTEIN pirllS22631 petPproteinRhodobacter capsulatus emb1CAA78097. 11 (Z12113) protein of unknown function [Rhodobacter capsulatus] Length = 166 SEQ ID NO 450 LI-4532. 1 No Hits found SEQ ID N 451 LI-3387 1 99 emblCAB53838 11 (AJ242593) putative recombinase [Bacteriophage A118] Length = 271 SEQ ID N 452 LI-11251 34 gblAAC97845 11 (AF063866) ORF MSV027 tryptophan repeat gene family protein [Melanoplus sanguinipes entomopoxvirus] Length = 297 SEQ ID NO 453 LI-4217 1 No Hits found SEQ ID N'454 LI-5704. 1 No Hits found SEQ ID DN 455 LI-2923. 1 41 gblAAC44021. 11 (U40830) Orf14. 9 protein [Streptococcus thermophilus] prf2209356Q ORF 14. 9 streptococcus thermophilus] Length = 191 SEQ ID N 456 LI-1393. 1 No Hits found SEQ ID N 457 LI-2461. 1 39 gblAAC44021 11 (U40830) Orf14. 9 protein [Streptococcus thermophilus] prf2209356Q ORF 14. 9 streptococcus thermophilus] Length = 191 SEQ ID N'458 LI-5483. 1 14 spIP057901FBOH-BOMMO FIBROIN HEAVY CHAIN PRECURSOR (FIB-H) (H-FIBROIN) gblAAF76983. 1 [AF2266881 (AF226688) fibroin heavy chain Fib-H [Bombyx mori] Length = 5263 SEQ ID N 459 LI-392. 1 49 emblCAB73650 11 (AL139079) putative ABC transport system ATP-binding protein [Campylobacter jejuni] Length = 217 SEQ ID N 460 LI-2950 1 No Hits found SEQ ID N"461 LI-6003 1 48 plrllB69784 conserved hypothetical protein ydhF-Bacillus subtills emb1CAB12392. 11 (Z99107) similar to hypothetical proteins from B. subtilis {Baci ! tus subt ! ! ! s] Length = 236 SEQ ID NO 462 LI-6065. 1 No Hits found SEQ ID N'463 LI-1578. 1 49 spIP469031NATA-BACSU ATP-BINDING TRANSPORT PROTEIN NATA (NA+ ABC TRANSPORTER) pir ! ! A69666 Na+ ABC transporter (extrusion) (ATPbinding protem) natA-Bacillus subtilis gblAAB53022 11 (U30873) NatA [Bacillus subtilis] dbjIBAA22236. 11 (AB0006 SEQ ID N 464 LI-4124. 1 82 gblAAC64335 11 (AF036485) putative transposase [Plasmid pNZ4000] Length = 226 SEQ ID N 465 LI-4139 1 82 gblAAC64335 11 (AF036485) putative transposase [Plasmid pNZ4000] Length = 226
SEQ ID NO 466 LI-4166. 1 94 emb1CM64387. 11 (X94761) transposase [Streptococcus thermophilus] emblCAB52228. 11 (Z98171) transposase [Streptococcus thermophilus] Length = 226 SEQ ID N'467 LI-4182. 1 82 gblAAC64335 11 (AF036485) putative transposase [Plasmid pNZ4000] Length = 226 SEQ ID N 468 LI-6038. 1 No Hits found SEQ ID N 469 LI-4021. 1 No Hits found SEQ ID N 470 LI-5569. 1 66 splP459321YQBPBACSU HYPOTHETICAL 25. 3 KD PROTEIN IN SPOIIICCWLA INTERGENIC REGION pirllC69948 phage-related protein homolog yqbP-Bacillus subtilis dbjBAA06948. 11 (D32216) ORF85 [Bacillus subtilis] dbjlBAA12412 11 (D84432) YqbP [Bacillus subtilis] SEQ ID N 471 LI-4084. 1 96 embjCAA63529. 11 (X92946) transposase [Lactococcus lactis] Length = 228 SEQ ID N"472 LI-4177. 1 97 emb1CM63529. 11 (X92946) transposase [Lactococcus lactis] Length = 228 SEQ D ? 473 LI-6066 1 23 emblCAB53799 11 (AJ242593) gp13 [Bacteriophage A118] Length = 110 SEQ ID N'474 LI-6106. 1 97 embICAA63529. 11 (X92946) transposase [Lactococcus lactis] Length = 228 SEQ ID N475 LI-6113. 1 97 emblCM63529 11 (X92946) transposase [Lactococcus lactis] Length = 228 SEQ ID N476 Lt-4013164gbjAAC48871 1 (U51128) ORF245 [Lactococcus bacteriophage phi31] Length = 245 SEQ ID N 477 LI-5978. 1 61 emb ! CAB40581. 11 (AJ010128) DNA alkylation repair enzyme bacillus cereus] Length = 237 SEQ ID N'478 LI-6085. 1 53 spIP459151YQAS-BACSU HYPOTHETICAL 27. 7 KD PROTEIN IN SPOIIICCWLA INTERGENIC REGION pirllB69946 phage-related termina se small subunit homolog yqaS-Bacillus subtilis dbjjBAA06932. 11nD32216) ORF43 [Bacillus subtilis] dbj1BM12394. 11 (084432 SEQ ID N 479 LI-1346. 1 15 pir rE75471 transcription regulator, GntR family-Deinococcus radiodurans (strain R1) gblAAF10394. 11AE001936-3 (AE001936) transcriptional regulator, GntR family [Deinococcus radiodurans] Length = 267 SEQ D ? 480 LI-4506 1 No Hits found SEQ ID ? 481 LI-3994 1 54 gblAAB18697 11 (U38906) ORF22 [Bacteriophage r1t] Length = 228 SEQ ID NN 482 LI-6131. 1 54 gblAAB18697 11 (U38906) ORF22 [Bacteriophage r1t] Length = 228 SEQ ID ? 483 LI-4050. 1 No Hits found SEQ ID N'484 LI-284. 1 57 pirlIF69375 ABC transporter, ATP-binding protein homolog-Archaeoglobus fulgidus gblAAB90232. 11 (AE001034) ABC transporter, ATP-binding protein [Archaeoglobus fulgidus] Length = 285 SEQ ID N 485 LI-4160. 1 65 gblAAB39096 11 (U39673) KdpE [Clostridium acetobutylicum] Length 232 SEQ ID N 486 LI-529. 1 47 dbjIBAA03592 11 (D14877) positive regulator for virulence factors [Clostridium perfringens Length = 236 SEQ ID N 487 LI-3559 1 No Hits found
SEQ ID N'488 LI-5643. 1 49 pirlID49898 cellobiose phosphotransferase system celc-Bacillus stearothermophilus gblAAA17391. 11 (U07818) putative phospho-betaglucosidase [Bacillus stearothermophilus] Length = 245 SEQ ID N489 LI-5720. 1 90 emblCAB53837 11 (AJ242593) gp47 [BacteriophageA118] Length =319 SEQ ID N 490 LI-2788. 1 46 gblAAF35174. 11 (AF193610) TndX [Clostridium difficile] Length = 533 SEQ ID N'491 LI-4054. 1 28 embICAB52531. 11 (AJ131519) hypothetical protein [Lactobacillus bacteriophage phi adh] Length = 247 SEQ ID N 492 LI-4095. 1 47 pirj) E71905 hypothetical protein jhp0651-Helicobacter pylori (strain J99) gblAAD06227 11 (AE001497) putative [Helicobacter pylori J99] Length = 234 SEQ ID ? 493 LI-5200. 1 34 2119294A YFW1 gene saccharomyces cerevisiae] Length = 605 SEQ ID N"494 LI-2995. 1 52 pir)) T12864 probable antirepressor-Bacillus subtilis phage SPBc2 emblCAB13959. 11 (Z99114) similar to phage-related DNA-binding protein anti-repressor [Bacillus subtilis] embjCABI 3985. 1l (Z99115) similar to phagerelated DNA-binding protein SEQ ID N 495 LI-5715 1 58 dbjlBAA97816 11 (AB044554) antlrepressor (Staphylococcus aureus prophage phiPV83] Length = 265 SEQ ID ? 496 LI-6019 1 38 p) rT00178 hypothetical protein 44-Staphylococcus aureus phage phi PVL dbjIBAA31918. 11 (AB009866) orf 44 [bacteriophage phi PVL] Length 161 SEQ ID ? 497 LI-2779. 1 27 pirj) G69486 probable iron-sulfur flavoprotein isf-3-Archaeoglobus fulgidus gb) AAB89371. 1) (AE000972) iron-su ! fur ftavoprotein (isf-3) [Archaeoglobus fulgidus] Length = 201 SEQ ID DN 498 LI-6144. 1 69 dbjlBAA97816 11 (AB044554) antirepressor [Staphylococcus aureus prophage phiPV83] Length = 265 SEQ ID NO 499 LI-19261 No Hits found SEQ ID N 500 LI-4026. 1 No Hits found SEQ ID NO 501 LI-13881 No Hits found SEQ ID ? 502 LI-2781. 1 47 pir rE70761 probable ketoacyl reductase-Mycobacterium tuberculosis (strain H37RV) emblCAA98318 11 (Z74020) hypothetical protein Rv1544 [Mycobacterium tuberculosis Length = 267 SEQ ID N"503 LI-3157 1 38 plrllG75518 probable beta-Iactamase-oeinococcus radiodurans (strain R1) gblAAF10013 11AE001903~1 (AE001903) beta-lactamase, putative [Deinococcus radiodurans] Length = 277 SEQ ID N'504 LI-485. 1 46 plrllH71283 conserved hypothetlcal integral membrane protein TP0771syphilis spirochete gblAAC65739. 11 (AE001248) conserved hypothetical Integral membrane protein [Treponema pallidum Length = 593 SEQ ID ? 505 LI-5604. 1 31 spIP45915jYQAS~BACSU HYPOTHETICAL 27. 7 KD PROTEIN IN SPOIIICCWLA INTERGENIC REGION pirllB69946 phage-related terminase small subunit homolog yqas-Bacillus subtilis dbjIBAA06932. 11 (D32216) ORF43 [Bac ! ! ! us subts] dbj) BAA12394. 1j (D84432 SEQ ID ? 506 U-4169 1No Hits found
SEQ ID N"507 LI-522. 1 40 reflNP-013953. Il Ymr226cp spIQ05016IYM71-YEAST HYPOTHETICAL OXIDOREDUCTASE IN MRPL44-MTF1 INTERGENIC REGION pirllS57593 hypothetical protein YMR226c-yeast (Saccharomyces cerevisiae) emblCAA90197. 11 (Z49939) unknown saccharomyces cerevisiae] SEQ ID N"508 LI-1513. 1 No Hits found SEQ ID NO 509 LI-6136. 1 98 emb1CAB53838. 11 (AJ242593) putative recombinase [BacteriophageA118] Length = 271 SEQ ID ? 510 LI-3148. 1 75 pirS16647 sporulation dipeptide ABC transporter dppA-Bacillus subtilis Length = 274 SEQ ID N 511 LI-5558. 1 No Hits found SEQ ID N 512 LI-4123. 1 68 gblAAB01067. 11 (U23813) transposase [Lactococcus lactis] Length = 385 SEQ ID N'513 LI-6052. 1 33 embICAB53803. 11 (AJ242593) gp17 [Bacteriophage AU18] Length = 272 SEQ ID NO 514 LI-1577 1 42 pirllB71197 hypothetical protein PH1848-Pyrococcus horikoshil dbjBAA30969 11 (AP000007) 255aa long hypothetical protein [Pyrococcus horikoshii] Length = 255 SEQ ID N'515 LI-3333. 1 61 embICAB53803. 11 (AJ242593) gp17 [Bacter ! ophageA118] Length = 272 SEQ ID N 516 LI-523. 1 37 pirlB59099 hypothetical protein pXO1-66-Bacillus anthracis virulence plasmid pXO1 gbAAD32370. 1lad32370 (AF065404) po1-66 [Bacillus anthracis] Length = 361 SEQ ID N"517 LI-10251 No Hits found SEQ ID N"518 LI-2947. 1 No Hits found SEQ ID N"519 LI-5550. 1 30 pirlIT12790 N-acetylmuramoyl-L-alanine amidase homolog-Bacillus subtilis phage SPBc2 embCAB14059. 11 (Z99115) similarto N-acetylmuramoyl-Lalanine amidase bacillus subti ! ! s] gb) AAC38300. 1) (AF021803) Nacetylmuramoyl-L-alanine SEQ ID N'520 LI-733. 1 20 pirlIA71161 hypothetical protein PH0486-Pyrococcus horikoshii dbj) BAA29574 11 (AP000002) 170aa long hypothetical protein [Pyrococcus horikoshii] Length = 170 SEQ ID ? 521 LI-4067. 1 39 gblAAA63619 11 (U10992) abiD [Lactococcus lactis] Length = 366 SEQ ID N 522 LI-4670 1 50 emblCAA78595 11 (Z14225) SpoHJ [Bacillus subtilis] Length = 259 SEQ ID ? 523 LI-4460 1 No Hits found SEQ ID NO 524 LI-41741 61 gblAAF37879 11AF234619~2 (AF234619) OpuABC [Lactococcus lactis] Length = 573 SEQ ID ? 525 LI-4148 1 66 spIP18179ATBPSTAAU POTENTIAL ATP-BINDING PROTEIN (ORF 271) pirjlS11779 probable ATP-binding protein-Staphylococcus aureus transposon Tn552 emb1CAA36948. 11 (X52734) ORF271 (pot. ATP-binding protein) (AA 1- 271) [Staphylococcus au SEQ ID N 526 LI-454. 1 No Hlts found SEQ ID ? 527 LI-3320 1 97 splQ379791AEPE-BPA50 L-ALANOYL-D-GLUTAMATE PEPTIDASE pirllS69801 L-alanoyl-D-glutamate peptidase, 33. 4K-phage A500 emblCAA59365 11 (X85009) L-alanoyl-D-glutamate peptidase [Bacteriophage A500] Length = 289
Caractérisation des fragments APP-Cter avec différentes sondes immunologiques Un anticorps dirigé contre la partie N-terminale du peptide Ab permet de localiser le fragment de coupure de la béta-secrétase. Il s'agit de l'anticorps FCA18 (Ancolio et al, (3)). Le fragment 14 kDa des globules blancs est détecté par cet anticorps (figure 9), indiquant qu'il s'agit du fragment APP-Cter produit par la béta secrétase (figure 10B). Par ailleurs, l'interrogation des bases de données (SwissProt par exemple) indique que le fragment APP-Cter de masse moléculaire de 9,5 kDa (figure 9) et de point isoélectrique 6,99 correspond au fragment alpha secrétase, comme représenté dans la figure 10B. Les deux fragments APP-Cter majeurs des globules blancs qui sont modifiés au cours de la maladie d'Alzheimer ont donc été identifiés (figure 10B).
Récapitulatif Des variants particulièrement informatifs pour la mise en #uvre de l'invention sont rapportés dans les tableaux récapitulatifs 1 à 3. Ces différents variants
constituent des marqueurs de grand intérêt pour détecter les modifications pathologiques de l'APP, aussi bien dans les tissus neuronaux que dans des lymphocytes.