BIBLIOGRAPHIE - Anderson et al., CRC Crit. Rev. Neurobiol., 1987, vol. 3, pp 245-99 - Antoine J.C. et al., Journal of the Neurological Sciences, 1993 vol. 117, pp 215-223 - Byk et al., Journal of Neuroscience, 1996, vol. 16(2), pp 688-701 - Dalmau et al., Neurology, 1991, vol. 41, pp 175764 - Duchemin et al., Dev Neurosci, 1987, vol. 9, pp 61-67 - Graus et al., Neurology, 1985, vol. 35, pp 538-543 - Graus et al., Neurology, 1990, vol. 40, pp 219-22 - Greenlee et al., Ann. Neurol., 1983, vol. 14, pp 609-13 - Hamajima et al., Gene, 1996, vol. 180, pp. 157-163 - Hetzel et al., Mayo Clin. Proc., 1990, vol. 65, pp 1558-63 - Honnorat J. et al., Journal of Neurology, Neurosurgery and Psychiatry, 1996, vol. 61, pp 270-278 - Jaeckle et al., Ann. Neurol., 1985, vol. 18, pp 592-600 - Kôhler et Milstein, Nature, 1975, vol. 256, pp 495497 - Levy N., Mattei MG., 1995, Geneprobs il, a practical approch. BD Hames and SJ Higgins, Oxford University Press, pp 211-243 - Luque et al., Ann. Neurol., 1991, vol. 29, pp 241-51 - Minturn et al., J. Neurosci., 1995, vol. 15, pp. 67576766 - Peltre G., Lapeyre J; David B., Immunol. Lett., 1982, vol. 5 pp 127-131 - Sambrook et al., Molecular Cloning, a laboratory Manual, 1989, 9.479.62 - Wang L-H et al., J. Neurosci., 1996, vol. 16(9), pp 61976207 LISTE DE SEQUENCES (1) INFORMATION GENERALE: (i) DEPOSANT: (A) NOM: Institut National de la Santé et de la recherche médicale (B) RUE: 101, rue de Tolbiac (C) VILLE: Paris (E) PAYS: FRANCE (F) CODE POSTAL: 75013 (G) TELEPHONE: 0144236000 (H) TELECOPIE: 0145856856 (ii) TITRE DE L' INVENTION: Utilisation des Ulip dans les SNP et les cancers associés (iii) NOMBRE DE SEQUENCES: 8 (iv) FORME LISIBLE PAR ORDINATEUR: (A) TYPE DE SUPPORT: Floppy disk (B) ORDINATEUR: IBM PC compatible (C) SYSTEME D'EXPLOITATION: PC-DOS/MS-DOS (D) LOGICIEL: PatentIn Release #1.0, Version #1.25 (OEB) (2) INFORMATION POUR LA SEQ ID NO: 1: (i) CARACTERISTIQUES DE LA SEQUENCE: (A) LONGUEUR: 1817 paires de bases (B) TYPE: acide nucléique (C) NOMBRE DE BRINS: simple (D) CONFIGURATION: linéaire (ii) TYPE DE MOLECULE: ADNc (vi) ORIGINE: (A) ORGANISME: Mus musculus (xi) DESCRIPTION DE LA SEQUENCE: SEQ ID NO: 1: CTTCCTCCCG CCCCCCGGAG AGATGTCTTA TCAGGGGAAG AAAAATATTC CACCCATCAC 60 GAGCGATCGT CTTCTGATCA AAGGTGGCAA GATTGTGAAT GATGACCAGT CCTTCTATGC 120 AGACATATAC ATGGAAGATG GGTTGATCAA GCAAATAGGA GAAAACCTGA TTGTACCAGG 180 AGGGGTGAAG ACCATCGAAG CCCACTCCAG AATGGTGATT CCCGGAGGAA TTGACGTGCA 240 TACTCGCTTC CAGATGCCTG ACCAGGGAAT GACATCCGCT GATGACTTCT TCCAGGGAAC 300 CAAGGCGGCC CTGGCCGGGG GAACCACCAT GATCATTGAC CATGTTGTTC CTGAGCCCGG 360 GACGAGCCTA TTGGCTGCCT TTGATCAGTG GAGGGAGTGG GCTGACAGCA AGTCCTGCTG 420 TGACTATTCG CTGCACGTGG ACATCACTGA GTGGCACAAG GGCATCCAGG AGGAGATGGA 480 AGCTCTGGTG AAGGACCACG GGGTAAACTC CTTCCTCGTG TACATGGCTT TCAAAGATCG 540 ATTCCAGCTG ACGGATTCCC AGATCTATGA AGTGCTGAGC GTGATCCGGG ATATCGGTGC 600 CATAGCTCAA GTCCACGCAG AGAATGGTGA CATCATTGCT GAGGCACAGC AGAGGATCCT 660 GGATCTGGGC ATCACGGGCC CCGAGGGACA CGTGTTGAGC CGGCCAGAGG AGGTCGAGGC 720 TGAAGCTGTG AACCGGTCCA TCACTATTGC CAACCAGACC AACTGCCCTC TGTATGTCAC 780 CAAAGTGATG CCCAAGAGTG CGGCTGAAGT CATCGCTCAG GCACGGAAGA AGGGAACTGT 840 GGTGTATGGT GAGCCCATCA CGGCCAGCCT GGGGACTGAT GGCTCTCATT ACTGGAGCAA 900 GAACTGGGCC AAGGCTGCGG CCTTTGTCAC CTCCCCACCC TTGAGCCCCG ACCCAACCAC 960 TCCAGACTTT CTCAACTCGT TGCTGTCCTG TGGAGACCTC CAAGTCACTG GCAGTGCCCA 1020 CTGCACCTTC AACACTGCCC AGAAGGCTGT GGGGAAGGAC AACTTCACCT TGATTCCCGA 1080 GGGCACCAAC GGCACTGAGG AGCGGATGTC TGTCATTTGG GATAAAGCTG TGGTCACTGG 1140 GAAGATGGAT GAGAATCAGT TTGTGGCTGT GACCAGCACC AACGCAGCCA AAGTCTTCAA 1200 CCTTTACCCC CGGAAAGGTC GCATCTCGGT GGGATCTGAT GCTGACTTGG TCATCTGGGA 1260 CCCTGACAGT GTGAAGACCA TCTCTGCCAA GACACACAAC AGTGCTCTTG AGTACAACAT 1320 CTTTGAAGGC ATGGAGTGTC GCGGCTCCCC ACTGGTGGTC ATCAGCCAGG GCAAGATTGT 1380 CCTGGAGGAC GGCACACTTC ATGTCACTGA AGGCTCAGGA CGCTACATTC CCCGGAAGCC 1440 CTTCCCTGAC TTTGTGTACA AACGCATCAA AGCAAGGAGC AGGCTGGCTG AGCTGAGAGG 1500 GGTCCCTCGT GGCCTGTATG ACGGACCGGT ATGCGAGGTG TCTGTGACGC CCAAGACGGT 1560 GACTCCAGCC TCATCAGCTA AGACATCCCC TGCCAAGCAG CAGGCACCAC CTGTTCGGAA 1620 CCTGCACCAG TCTGGATTCA GCTTGTCTGG TGCTCAGATT GACGACAACA TTCCCCGCCG 1680 CACCACCCAG CGCATCGTGG CACCCCCTGG TGGCCGTGCC AACATCACCA GCCTGGGCTA 1740 AAGCCCCTAG GCCTGCAGGC CACTTGGGGA TGGGGGATGG GACACCTGAG GACATTCTGA 1800 GACTTCCTTT CTTCCAT 1817 (2) INFORMATION POUR LA SEQ ID NO: 2: (i) CARACTERISTIQUES DE LA SEQUENCE: (A) LONGUEUR: 572 acides aminés (B) TYPE: acide aminé (C) NOMBRE DE BRINS: simple (D) CONFIGURATION: linéaire (ii) TYPE DE MOLECULE: peptide (vi) ORIGINE: (A) ORGANISME: Mus musculus (xi) DESCRIPTION DE LA SEQUENCE: SEQ ID NO: 2: Met Ser Tyr Gln Gly Lys Lys Asn Ile Pro Pro Ile Thr Ser Asp Arg 1 5 10 15 Leu Leu Ile Lys Gly Gly Lys Ile Val Asn Asp Asp Gln Ser Phe Tyr 20 25 30 Ala Asp Ile Tyr Met Glu Asp Gly Leu Ile Lys Gln Ile Gly Glu Asn 35 40 45 Leu Ile Val Pro Gly Gly Val Lys Thr Ile Glu Ala His Ser Arg Met 50 55 60 Val Ile Pro Gly Gly Ile Asp Val His Thr Arg Phe Gln Met Pro Asp 65 70 75 80 Gln Gly Met Thr Ser Ala Asp Asp Phe Phe Gln Gly Thr Lys Ala Ala 85 90 95 Leu Ala Gly Gly Thr Thr Met Ile Ile Asp His Val Val Pro Glu Pro 100 105 110 Gly Thr Ser Leu Leu Ala Ala Phe Asp Gln Trp Arg Glu Trp Ala Asp 115 120 125 Ser Lys Ser Cys Cys Asp Tyr Ser Leu His Val Asp Ile Thr Glu Trp 130 135 140 His Lys Gly Ile Gln Glu Glu Met Glu Ala Leu Val Lys Asp His Gly 145 150 155 160 Val Asn Ser Phe Leu Val Tyr Met Ala Phe Lys Asp Arg Phe Gln Leu 165 170 175 Thr Asp Ser Gln Ile Tyr Glu Val Leu Ser Val Ile Arg Asp Ile Gly 180 185 190 Ala Ile Ala Gin Val His Ala Glu Asn Gly Asp île Ile Ala Glu Ala 195 200 205 Gln Gln Arg Ile Leu Asp Leu Gly Ile Thr Gly Pro Glu Gly His Val 210 215 220 Leu Ser Arg Pro Glu Glu Val Glu Ala Glu Ala Val Asn Arg Ser Ile 225 230 235 240 Thr Ile Ala Asn Gln Thr Asn Cys Pro Leu Tyr Val Thr Lys Val Met 245 250 255 Pro Lys Ser Ala Ala Glu Val Ile Ala Gln Ala Arg Lys Lys Gly Thr 260 265 270 Val Val Tyr Gly Glu Pro Ile Thr Ala Ser Leu Gly Thr Asp Gly Ser 275 280 285 His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr Ser 290 295 300 Pro Pro Leu Ser Pro Asp Pro Thr Thr Pro Asp Phe Leu Asn Ser Leu 305 310 315 320 Leu Ser Cys Gly Asp Leu Gln Val Thr Gly Ser Ala His Cys Thr Phe 325 330 335 Asn Thr Ala Gln Lys Ala Val Gly Lys Asp Asn Phe Thr Leu Ile Pro 340 345 350 Glu Gly Thr Asn Gly Thr Glu Glu Arg Met Ser Val Ile Trp Asp Lys 355 360 365 Ala Val Val Thr Gly Lys Met Asp Glu Asn Gln Phe Val Ala Val Thr 370 375 380 Ser Thr Asn Ala Ala Lys Val Phe Asn Leu Tyr Pro Arg Lys Gly Arg 385 390 395 400 Ile Ser Val Gly Ser Asp Ala Asp Leu Val Ile Trp Asp Pro Asp Ser 405 410 415 Val Lys Thr Ile Ser Ala Lys Thr His Asn Ser Ala Leu Glu Tyr Asn 420 425 430 Ile Phe Glu Gly Met Glu Cys Arg Gly Ser Pro Leu Val Val Ile Ser 435 440 445 Gln Gly Lys Ile Val Leu Glu Asp Gly Thr Leu His Val Thr Glu Gly 450 455 460 Ser Gly Arg Tyr Ile Pro Arg Lys Pro Phe Pro Asp Phe Val Tyr Lys 465 470 475 480 Arg Ile Lys Ala Arg Ser Arg Leu Ala Glu Leu Arg Gly Val Pro Arg 485 490 495 Gly Leu Tyr Asp Gly Pro Val Cys Glu Val Ser Val Thr Pro Lys Thr 500 505 510 Val Thr Pro Ala Ser Ser Ala Lys Thr Ser Pro Ala Lys Gln Gln Ala 515 520 525 Pro Pro Val Arg Asn Leu His Gln Ser Gly Phe Ser Leu Ser Gly Ala 530 535 540 Gln Ile Asp Asp Asn Ile Pro Arg Arg Thr Thr Gln Arg Ile Val Ala 545 550 555 560 Pro Pro Gly Gly Arg Ala Asn Ile Thr Ser Leu Gly 565 570 (2) INFORMATION POUR LA SEQ ID NO: 3: (i) CARACTERISTIQUES DE LA SEQUENCE: (A) LONGUEUR: 2297 paires de bases (B) TYPE: acide nucléique (C) NOMBRE DE BRINS: simple (D) CONFIGURATION: linéaire (ii) TYPE DE MOLECULE: ADNc (vi) ORIGINE: (A) ORGANISME: Mus musculus (xi) DESCRIPTION DE LA SEQUENCE: SEQ ID NO: 3: GCTGTCTGTC TTCAGCGCCC TCCTCTCGCC CTGCCTCTCC CTCCTCCTCC CGCCCTCCTT 60 GCCAAGCCGG GCGGTGCAGG CAGCCGGAGC AGCGGCGGCG GGCCGAGCAG CGGGGAGTGG 120 GCAGCGGTGG GAGCCGAGCT TCTGTCCTTT CTTTCATCCC TCCCTGGCCT TTGTCGCCGC 180 TCTCACGAGT AGCGCCGCCG GGAGAGACCC GGGTAGAGCG CCAGGCAGAC GTTAGTTCCA 240 GCGGCCGGGC GGAGGGCTCC AGAGGGGCCA TGTCTCATCA GGGGAAGAAG AGCATCCCGC 300 ACATCACCAG TGACCGGCTC CTCATCAGAG GTGGACGCAT CATCAATGAT GACCAGTCCT 360 TCTACGCCGA TGTCTACCTA GAAGATGGAC TCATAAAACA AATAGGAGAG AACCTGATTG 420 TTCCTGGTGG AGTGAAGACC ATCGAGGCGA ATGGCCGAAT GGTCATTCCC GGTGGCATTG 480 ATGTCAACAC TTACCTGCAG AAGCCCTCCC AGGGCATGAC CTCGGCTGAT GACTTCTTCC 540 AGGGCACTAA AGCAGCGCTG GCAGGTGGAA CCACGATGAT CATTGACCAC GTTGTTCCTG 600 AACCTGGGTC CAGCTTGTTG ACTTCCTTTG AGAAATGGCA CGAAGCAGCA GACACCAAAT 660 CCTGCTGTGA CTATTCCCTC CACGTGGACA TCACAAGCTG GTATGATGGT GTTCGGGAAG 720 AGCTGGAGGT GCTGGTGCAG GACAAAGGTG TCAACTCCTT CCAAGTCTAC ATGGCGTATA 780 AGGACCTGTA CCAGATGTCT GACAGCCAGC TGTATGAAGC CTTCACCTTC CTTAAGGGTT 840 TGGGAGCTGT GATCTTAGTC CATGCAGAAA ATGGAGATTT GATAGCTCAG GAACAAAAAC 900 GGATCCTGGA GATGGGCATC ACGGGTCCCG AGGGTCATGC TCTGAGCAGA CCCGAGGAGC 960 TGGAGGCCGA GGCTGTGTTC CGGGCTATTG CCATTGCAGG CCGGATCAAT TGCCCTGTGT 1020 ACATCACCAA GGTCATGAGC AAGAGTGCAG CGGACATCAT CGCACTGGCC AGGAAGAAAG 1080 GCCCTCTTGT CTTCGGTGAG CCCATAGCCG CCAGCCTGGG AACCGATGGC ACCCACTACT 1140 GGAGCAAGAA CTGGGCCAAG GCAGCTGCAT TTGTGACTTC CCCTCCCCTG AGCCCAGACC 1200 CCACCACTCC TGACTACTTG ACCTCCTTGC TGGCCTGTGG AGACTTGCAG GTCACAGGTA 1260 GTGGCCACTG TCCCTACAGT ATTGCTCAGA AGGCTGTGGG CAAGGACAAC TTCACTCTGA 1320 TCCCTGAGGG TGTCAATGGT ATAGAAGAGC GGATGACCGT TGTCTGGGAC AAGGCAGTGG 1380 CTACTGGCAA GATGGATGAG AACCAGTTTG TAGCCGTCAC CAGCACCAAC GCAGCCAAGA 1440 TCTTCAACCT GTACCCGAGG AAAGGTCGGA TCGCTGTGGG CTCCGATGCT GACGTAGTCA 1500 TCTGGGACCC AGATAAGATG AAGACCATAA CAGCCAAAAG CCATAAATCA ACTGTGGAGT 1560 ACAACATCTT TGAGGGCATG GAGTGCCACG GCTCCCCCCT GGTGGTCATC AGTCAGGGCA 1620 AGATTGTCTT TGAGGATGGA AACATCAGTG TCAGCAAGGG CATGGGCCGC TTCATCCCTC 1680 GGAAGCCATT CCCAGAGCAT CTCTACCAGC GTGTCAGGAT CAGAAGCAAG GTTTTCGGGT 1740 TGCATAGTGT TTCCAGGGGC ATGTACGATG GGCCTGTGTA CGAGGTGCCA GCTACACCCA 1800 AACATGCTGC TCCTGCTCCT TCTGCCGAAT CCTCGCCTTC TAAACACCAA CCCCCACCCA 1860 TCCGGAACCT CCACCAGTCC AACTTCAGCT TATCAGGTGC CCAGATAGAT GACAACAATC 1920 CAAGGCGTAC AGGCCACCGC ATTGTGGCGC CCCCTGGTGG CCGCTCCAAC ATCACCAGCC 1980 TCGGTTGACC TCAGATGAGC CAGATATGCA AGAGTGAAGG ATTATGGGAA AACGTCCATT 2040 CCTTTTCCGT GTTTTTGAAG CCCACAGTTT TAGTTGGTAC TGACGGAGGG GAGATTGAGC 2100 GATGCTCTTT CCTTCTCTGT TTAGGAAGAA GTGGTACTAG TGTGGTGTGT TTGCCTGGAA 2160 GTCCCTCGCC CACAGTGTGT GTTCACACCG ACTCCACCTC AGAGCATGGT GCCGTCCGTT 2220 TTCCCTTCCT AGTGACCCCA GGTTTAGCAT CGTCCTATAC TGTTCCCTCC ACTCCTCCAT 2280 GACCCTCTGA GTGATGG 2297 (2) INFORMATION POUR LA SEQ ID NO: 4: (i) CARACTERISTIQUES DE LA SEQUENCE: (A) LONGUEUR: 572 acides aminés (B) TYPE: acide aminé (C) NOMBRE DE BRINS: simple (D) CONFIGURATION: linéaire (ii) TYPE DE MOLECULE: peptide (vi) ORIGINE: (A) ORGANISME: Mus musculus (xi) DESCRIPTION DE LA SEQUENCE: SEQ ID NO: 4: Met Ser His Gln Gly Lys Lys Ser Ile Pro His Ile Thr Ser Asp Arg 1 5 10 15 Leu Leu Ile Arg Gly Gly Arg Ile Ile Asn Asp Asp Gln Ser Phe Tyr 20 25 30 Ala Asp Val Tyr Leu Glu Asp Gly Leu Ile Lys Gln Ile Gly Glu Asn 35 40 45 Leu Ile Val Pro Gly Gly Val Lys Thr Ile Glu Ala Asn Gly Arg Met 50 55 60 Val Ile Pro Gly Gly Ile Asp Val Asn Thr Tyr Leu Gln Lys Pro Ser 65 70 75 80 Gln Gly Met Thr Ser Ala Asp Asp Phe Phe Gln Gly Thr Lys Ala Ala 85 90 95 Leu Ala Gly Gly Thr Thr Met Ile Ile Asp His Val Val Pro Glu Pro 100 105 110 Gly Ser Ser Leu Leu Thr Ser Phe Glu Lys Trp His Glu Ala Ala Asp 115 120 125 Thr Lys Ser Cys Cys Asp Tyr Ser Leu His Val Asp Ile Thr Ser Trp 130 135 140 Tyr Asp Gly Val Arg Glu Glu Leu Glu Val Leu Val Gln Asp Lys Gly 145 150 155 160 Val Asn Ser Phe Gln Val Tyr Met Ala Tyr Lys Asp Leu Tyr Gln Met 165 170 175 Ser Asp Ser Gln Leu Tyr Glu Ala Phe Thr Phe Leu Lys Gly Leu Gly 180 185 190 Ala Val Ile Leu Val His Ala Glu Asn Gly Asp Leu Ile Ala Gln Glu 195 200 205 Gln Lys Arg Ile Leu Glu Met Gly Ile Thr Gly Pro Glu Gly His Ala 210 215 220 Leu Ser Arg Pro Glu Glu Leu Glu Ala Glu Ala Val Phe Arg Ala Ile 225 230 235 240 Ala Ile Ala Gly Arg Ile Asn Cys Pro Val Tyr Ile Thr Lys Val Met 245 250 255 Ser Lys Ser Ala Ala Asp Ile Ile Ala Leu Ala Arg Lys Lys Gly Pro 260 265 270 Leu Val Phe Gly Glu Pro Ile Ala Ala Ser Leu Gly Thr Asp Gly Thr 275 280 285 His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr Ser 290 295 300 Pro Pro Leu Ser Pro Asp Pro Thr Thr Pro Asp Tyr Leu Thr Ser Leu 305 310 315 320 Leu Ala Cys Gly Asp Leu Gln Val Thr Gly Ser Gly His Cys Pro Tyr 325 330 335 Ser île Ala Gln Lys Ala Val Gly Lys Asp Asn Phe Thr Leu Ile Pro 340 345 350 Glu Gly Val Asn Gly Ile Glu Glu Arg Met Thr Val Val Trp Asp Lys 355 360 365 Ala Val Ala Thr Gly Lys Met Asp Glu Asn Gln Phe Val Ala Val Thr 370 375 380 Ser Thr Asn Ala Ala Lys Ile Phe Asn Leu Tyr Pro Arg Lys Gly Arg 385 390 395 400 Ile Ala Val Gly Ser Asp Ala Asp Val Val Ile Trp Asp Pro Asp Lys 405 410 415 Met Lys Thr Ile Thr Ala Lys Ser His Lys Ser Thr Val Glu Tyr Asn 420 425 430 Ile Phe Glu Gly Met Glu Cys His Gly Ser Pro Leu Val Val Ile Ser 435 440 445 Gln Gly Lys Ile Val Phe Glu Asp Gly Asn Ile Ser Val Ser Lys Gly 450 455 460 Met Gly Arg Phe Ile Pro Arg Lys Pro Phe Pro Glu His Leu Tyr Gln 465 470 475 480 Arg Val Arg Ile Arg Ser Lys Val Phe Gly Leu His Ser Val Ser Arg 485 490 495 Gly Met Tyr Asp Gly Pro Val Tyr Glu Val Pro Ala Thr Pro Lys His 500 505 510 Ala Ala Pro Ala Pro Ser Ala Glu Ser Ser Pro Ser Lys His Gln Pro 515 520 525 Pro Pro Ile Arg Asn Leu His Gln Ser Asn Phe Ser Leu Ser Gly Ala 530 535 540 Gln Ile Asp Asp Asn Asn Pro Arg Arg Thr Gly His Arg Ile Val Ala 545 550 555 560 Pro Pro Gly Gly Arg Ser Asn Ile Thr Ser Leu Gly 565 570 (2) INFORMATION POUR LA SEQ ID NO:5: (i) CARACTERISTIQUES DE LA SEQUENCE: (A) LONGUEUR: 1920 paires de bases (B) TYPE: acide nucléique (C) NOMBRE DE BRINS: simple (D) CONFIGURATION: linéaire (ii) TYPE DE MOLECULE: ADNc (vi) ORIGINE: (A) ORGANISME: Mus musculus (xi) DESCRIPTION DE LA SEQUENCE: SEQ ID NO: 5: GCTGACTAAT ATGCTTAAAT TCAGCGGGTC GCCACGTCTG GTCGGTACGT CCACGCCCGC 60 GCAGCCCCTA CCGAGGACAC TCAGCCCGCC CGTGTATCAG GATGTCCTTC CAAGGCAAGA 120 AGAGCATTCC CCGGATAACG AGCGACCGCC TTCTCATCAA AGGTGGGAAG ATTGTGAACG 180 ATGACCAGTC CTTTCATGCT GATCTGTATG TGGAAGACGG TCTGATTAAA CAAATTGGAG 240 AAAATCTCAT CGTCCCTGGG GGCATCAAAA CCATCGATGC TCATGGCCTG ATGGTGCTGC 300 CTGGGGGAGT TGACGTTCAC ACCCGGCTGC AGATGCCTGT GATGGGCATG ACCCCAGCTG 360 ATGATTTCTG TCAGGGCACC AAGGCGGCTC TAGCAGGCGG GACCACCATG ATATTGGACC 420 ATGTGTTTCC TGACGCTGGT GTGAGCCTGC TGGCAGCCTA TGAGCAGTGG CGGGACGGAG 480 CAGACAGCGC GGCCTGCTGT GACTACTCCT TACATGTGGA CATTCCTCGC TGGCACGAGA 540 GCACCAAAGA AGAGCTGGAG GCCCTAGTCA GGGACAAAGG TGTGAACTCC TTCCTGGTCT 600 TCATGGCATA CAAGGACAGG TGCCAGTGTA CTGACGGTCA GATATATGAA ATCTTCAGCC 660 TCATCCGGGA CCTGGGAGCT GTGGCCCAGG TGCACGCAGA AAATGGGGAC ATCGTGGAGG 720 AGGAACAGAA GCGCCTGCTG GAGCAAGGCA TCACTGGTCC TGAGGGCCAT GTGCTCAGCC 780 ACCCAGAAGA GGTAGAGGCC GAGGCTGTGT ACAGAGCAGT CACCATTGCC AAGCAGGCCA 840 ACTGCCCACT ATACGTCACC AAGGTGATGA GCAAGGGTGC AGCTGACATG GTTGCCCAAG 900 CCAAGCGCAG GGGGGTGGTC GTCTTTGGGG AACCTATCAC TGCCAGCCTG GGCACTGATG 960 GCTCACACTA CTGGAGCAAG AACTGGGCCA AGGCTGCAGC CTTTGTCACT TCACCCCCTA 1020 TCAACCCGGA CCCTACTACT GCAGACCACC TCACCTCTCT GCTGTCCAGT GGGGACCTCC 1080 AGGTGACAGG CAGTGCCCAC TGCACCTTCA CTACTGCCCA GAAGGCTGTT GGCAAAGACA 1140 ACTTCACACT GATCCCCGAG GTAGTCAACG GTATAGAAGA GCGCATGTCT GTGGTCTGGG 1200 AGAAATGTGT GGCTTCAGGG AAAATGGACG AGAATGAGTT CGTTGCCGTG ACCAGCACAA 1260 ATGCTGCCAA AATCTTCAAT TTTTACCCCA GGAAGGGGCG TGTGGCCGTG GGCTCTGATG 1320 CTGACCTGGT CATCTGGAAC CCCAGGGCCA CGAAAGTCAT CTCTGCCAAG AGCCATAACC 1380 TGAATGTAGA GTACAACATC TTTGAAGGAG TGGAGTGCCG AGGAGTGCCC ACGGTGGTCA 1440 TAAGTCAGGG CAGAGTGGTG CTGGAGGACG GAAACCTGCT TGTCACTCCA GGGGCTGGCC 1500 GCTTCATTCC CCGGAAGACG TTCCCGGACT TTGTCTATAA GAGGATAAAG GCTCGCAACA 1560 GGCTAGCAGA GATCCACGGT GTGCCTCGAG GCCTGTACGA CGGGCCTGTG CATGAAGTGA 1620 TGTTACCTGC CAAGCCAGGA AGTGGCACAC AGGCCCGTGC ATCCTGTTCA GGCAAGATCT 1680 CAGTGCCACC CGTGCGCAAC CTGCACCAGT CGGGGTTCAG CCTATCTGGC TCTCAGGCTG 1740 ACGATCACAT TGCCAGACGT ACGG (2) INFORMATION POUR LA SEQ ID NO: 6: (i) CARACTERISTIQUES DE LA SEQUENCE: (A) LONGUEUR: 572 acides aminés (B) TYPE: acide aminé (C) NOMBRE DE BRINS: simple (D) CONFIGURATION: linéaire (ii) TYPE DE MOLECULE: peptide (vi) ORIGINE: (A) ORGANISME: Mus musculus (xi) DESCRIPTION DE LA SEQUENCE: SEQ ID NO: 6: Met Ser Phe Gln Gly Lys Lys Ser Ile Pro Arg Ile Thr Ser Asp Arg 1 5 10 15 Leu Leu Ile Lys Gly Gly Lys Ile Val Asn Asp Asp Gln Ser Phe His 20 25 30 Ala Asp Leu Tyr Val Glu Asp Gly Leu Ile Lys Gln Ile Gly Glu Asn 35 40 45 Leu Ile Val Pro Gly Gly Ile Lys Thr Ile Asp Ala His Gly Leu Met 50 55 60 Val Leu Pro Gly Gly Val Asp Val His Thr Arg Leu Gln Met Pro Val 65 70 75 80 Met Gly Met Thr Pro Ala Asp Asp Phe Cys Gln Gly Thr Lys Ala Ala 85 90 95 Leu Ala Gly Gly Thr Thr Met Ile Leu Asp His Val Phe Pro Asp Ala 100 105 110 Gly Val Ser Leu Leu Ala Ala Tyr Glu Gln Trp Arg Asp Gly Ala Asp 115 120 125 Ser Ala Ala Cys Cys Asp Tyr Ser Leu His Val Asp Ile Pro Arg Trp 130 135 140 His Glu Ser Thr Lys Glu Glu Leu Glu Ala Leu Val Arg Asp Lys Gly 145 150 155 160 Val Asn Ser Phe Leu Val Phe Met Ala Tyr Lys Asp Arg Cys Gln Cys 165 170 175 Thr Asp Gly Gln Ile Tyr Glu Ile Phe Ser Leu Ile Arg Asp Leu Gly 180 185 190 Ala Val Ala Gln Val His Ala Glu Asn Gly Asp Ile Val Glu Glu Glu 195 200 205 Gln Lys Arg Leu Leu Glu Gln Gly Ile Thr Gly Pro Glu Gly His Val 210 215 220 Leu Ser His Pro Glu Glu Val Glu Ala Glu Ala Val Tyr Arg Ala Val 225 230 235 240 Thr Ile Ala Lys Gln Ala Asn Cys Pro Leu Tyr Val Thr Lys Val Met 245 250 255 Ser Lys Gly Ala Ala Asp Met Val Ala Gln Ala Lys Arg Arg Gly Val 260 265 270 Val Val Phe Gly Glu Pro Ile Thr Ala Ser Leu Gly Thr Asp Gly Ser 275 280 285 His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr Ser 290 295 300 Pro Pro Ile Asn Pro Asp Pro Thr Thr Ala Asp His Leu Thr Ser Leu 305 310 315 320 Leu Ser Ser Gly Asp Leu Gln Val Thr Gly Ser Ala His Cys Thr Phe 325 330 335 Thr Thr Ala Gln Lys Ala Val Gly Lys Asp Asn Phe Thr Leu Ile Pro 340 345 350 Glu Val Val Asn Gly Ile Glu Glu Arg Met Ser Val Val Trp Glu Lys 355 360 365 Cys Val Ala Ser Gly Lys Met Asp Glu Asn Glu Phe Val Ala Val Thr 370 375 380 Ser Thr Asn Ala Ala Lys Ile Phe Asn Phe Tyr Pro Arg Lys Gly Arg 385 390 395 400 Val Ala Val Gly Ser Asp Ala Asp Leu Val Ile Trp Asn Pro Arg Ala 405 410 415 Thr Lys Val Ile Ser Ala Lys Ser His Asn Leu Asn Val Glu Tyr Asn 420 425 430 Ile Phe Glu Gly Val Glu Cys Arg Gly Val Pro Thr Val Val Ile Ser 435 440 445 Gln Gly Arg Val Val Leu Glu Asp Gly Asn Leu Leu Val Thr Pro Gly 450 455 460 Ala Gly Arg Phe Ile Pro Arg Lys Thr Phe Pro Asp Phe Val Tyr Lys 465 470 475 480 Arg Ile Lys Ala Arg Asn Arg Leu Ala Glu Ile His Gly Val Pro Arg 485 490 495 Gly Leu Tyr Asp Gly Pro Val His Glu Val Met Leu Pro Ala Lys Pro 500 505 510 Gly Ser Gly Thr Gln Ala Arg Ala Ser Cys Ser Gly Lys Ile Ser Val 515 520 525 Pro Pro Val Arg Asn Leu His Gln Ser Gly Phe Ser Leu Ser Gly Ser 530 535 540 Gln Ala Asp Asp His Ile Ala Arg Arg Thr Ala Gln Lys Ile Met Ala 545 550 555 560 Pro Pro Gly Gly Arg Ser Asn Ile Thr Ser Leu Ser 565 570 (2) INFORMATION POUR LA SEQ ID NO: 7: (i) CARACTERISTIQUES DE LA SEQUENCE: (A) LONGUEUR: 1690 paires de bases (B) TYPE: acide nucléique (C) NOMBRE DE BRINS: simple (D) CONFIGURATION: linéaire (ii) TYPE DE MOLECULE: ADNc (vi) ORIGINE: (A) ORGANISME: Homo sapiens (xi) DESCRIPTION DE LA SEQUENCE: SEQ ID NO: 7: GCCGCCCCTA CCAGAGACCC CCAGGAGCAG GATGTCCTTC CAGGGCAAGA AAAGCATCCC 60 CCGGATCACG AGTGACCGCC TTCTGATCAG AGGTGGGAGG ATCGTGAATG ACGACCAGTC 120 CTTTTACGCT GATGTGCACG TGGAAGATGG CTTGATAAAA CAAATCGGAG AAAACCTCAT 180 CGTCCCTGGG GGCATCAAGA CCATTGACGC CCACGGCCTG ATGGTCCTTC CTGGTGGCGT 240 TGACGTCCAC ACAAGGCTGC AGATGCCTGT CCTGGGCATG ACACCGGCTG ACGACTTCTG 300 TCAGGGCACC AAGGCAGCGC TAGCAGGAGG AACCACCATG ATCTTGGACC ACGTCTTCCC 360 CGACACGGGT GTGAGCCTGC TGGCGGCCTA CGAGCAGTGG CGGGAGCGGG CGGACAGCGC 420 GGCCTGCTGC GACTACTCCC TGCACGTGGA CATCACCCGA TGGCATGAGA GCATCAAGGA 480 GGAGCTGGAG GCCCTGGTCA AGGAGAAGGG TGTGAACTCC TTCCTGGTCT TCATGGCATA 540 CAAGGACCGG TGCCAGTGCA GCGACAGCCA GATGTACGAG ATCTTCAGCA TCATCCGGGA 600 CCTGGGGGCC TTGGCCCAGG TGCACGCTGA GAACGGGGAC ATCGTGGAGG AGGAGCAGAA 660 GCGGTTGCTG GAGCTCGGCA TCACTGGCCC CGAGGGCCAC GTGCTCAGCC ACCCCGAGGA 720 GGTGGAGGCT GAGGCGGTGT ACCGAGCTGT CACCATCGCC AAGCAGGCAA ACTGCCCGCT 780 GTACGTCACC AAGGTGATGA GCAAGGGGGC GGCCGACGCC ATCGCTCAGG CCAAGCGCAG 840 AGGGGTGGTC GTGTTTGGGG AGCCCATCAC CGCCAGCCTG GGCACCGACG GTTCACACTA 900 CTGGAGCAAG AACTGGGCCA AGGCTGCAGC CTTCGTCACA TCACCCCCTG TCAACCCAGA 960 CCCCACCACG GCAGACCACC TCACCTGCTT GCTGTCCAGC GGGGACCTCC AGGTGACAGG 1020 CAGCGCCCAC TGCACCTTCA CCACTGCCCA GAAGGCTGTG GGCAAGGACA ACTTCGCGCT 1080 GATCCCCGAG GGCACCAACG GCATTGAGGA GCGCATGTCG ATGGTCTGGG AGAAATGTGT 1140 GGCCTCTGGG AAGATGGACG AGAATGAGTT CGTCGCGGTG ACCAGTACAA ATGCTGCCAA 1200 AATCTTCAAT TTTTACCCAA GGAAGGGGCG AGTGGCTGTG GGCTCTGACG CTGACCTGGT 1260 CATATGGAAC CCCAAGGCCA CCAAGATCAT CTCTGCCAAG ACCCACAATC TGAACGTGGA 1320 GTACAACATC TTCGAGGGAG TGGAGTGCCG GGGAGCGCCT GCCGTGGTCA TAAGTCAGGG 1380 CCGAGTGGCG CTGGAGGACG GGAAGATGTT TGTCACCCCG GGGGCGGGCC GCTTCGTCCC 1440 TCGGAAAACA TTCCCGGACT TTGTCTACAA GAGGATCAAA GCTCGCAACA GGCTGGCGGA 1500 GATCCACGGT GTGCCCCGTG GGCTGTATGA CGGGCCCGTC CACGAGGTGA TGGTGCCTGC 1560 CAAGCCAGGG AGTGGCGCTC CGGCCCGCGC GTCCTGCCCA GGCAAGATCT CCGTGCCTCC 1620 TGTGCGCAAC CTACATCAGT CGGGGTTCAG CCTATCTGGG TCTCAGGCTG ATGACCACAT 1680 CGCCCGACGC 1690 (2) INFORMATION POUR LA SEQ ID NO: 8: (i) CARACTERISTIQUES DE LA SEQUENCE: (A) LONGUEUR: 572 acides aminés (B) TYPE: acide aminé (C) NOMBRE DE BRINS: simple (D) CONFIGURATION: linéaire (ii) TYPE DE MOLECULE: peptide (vi) ORIGINE: (A) ORGANISME: Homo sapiens (xi) DESCRIPTION DE LA SEQUENCE: SEQ ID NO: 8: Met Ser Phe Gln Gly Lys Lys Ser Ile Pro Arg Ile Thr Ser Asp Arg 1 5 10 15 Leu Leu Ile Arg Gly Gly Arg Ile Val Asn Asp Asp Gln Ser Phe Tyr 20 25 30 Ala Asp Val His Val Glu Asp Gly Leu Ile Lys Gln Ile Gly Glu Asn 35 40 45 Leu Ile Val Pro Gly Gly Ile His Thr Ile Asp Ala His Gly Leu Met 50 55 60 Val Leu Pro Gly Gly Val Asp Val His Thr Arg Leu Gln Met Pro Val 65 70 75 80 Leu Gly Met Thr Pro Ala Asp Asp Phe Cys Gln Gly Thr Lys Ala Ala 85 90 95 Leu Ala Gly Gly Thr Thr Met Ile Leu Asp His Val Phe Pro Asp Thr 100 105 110 Gly Val Ser Leu Leu Ala Ala Tyr Glu Gln Trp Arg Glu Arg Ala Asp 115 120 125 Ser Ala Ala Cys Cys Asp Tyr Ser Leu His Val Asp Ile Thr Arg Trp 130 135 140 His Glu Ser Ile Lys Glu Glu Leu Glu Ala Leu Val Lys Glu Lys Gly 145 150 155 160 Val Asn Ser Phe Leu Val Phe Met Ala Tyr Lys Asp Arg Cys Gln Cys 165 170 175 Ser Asp Ser Gln Met Tyr Glu Ile Phe Ser Ile Ile Arg Asp Leu Gly 180 185 190 Ala Leu Ala Gln Val His Ala Glu Asn Gly Asp Ile Val Glu Glu Glu 195 200 205 Gln Lys Arg Leu Leu Glu Leu Gly Ile Thr Gly Pro Glu Gly His Val 210 215 220 Leu Ser His Pro Glu Glu Val Glu Ala Glu Ala Val Tyr Arg Ala Val 225 230 235 240 Thr Ile Ala Lys Gln Ala Asn Cys Pro Leu Tyr Val Thr Lys Val Met 245 250 255 Ser Lys Gly Ala Ala Asp Ala Ile Ala Gln Ala Lys Arg Arg Gly Val 260 265 270 Val Val Phe Gly Glu Pro Ile Thr Ala Ser Leu Gly Thr Asp Gly Ser 275 280 285 His Tyr Trp Ser Lys Asn Trp Ala Lys Ala Ala Ala Phe Val Thr Ser 290 295 300 Pro Pro Val Asn Pro Asp Pro Thr Thr Ala Asp His Leu Thr Cys Leu 305 310 315 320 Leu Ser Ser Gly Asp Leu Gln Val Thr Gly Ser Ala His Cys Thr Phe 325 330 335 Thr Thr Ala Gln Lys Ala Val Gly Lys Asp Asn Phe Ala Leu Ile Pro 340 345 350 Glu Gly Thr Asn Gly Ile Glu Glu Arg Met Ser Met Val Trp Glu Lys 355 360 365 Cys Val Ala Ser Gly Lys Met Asp Glu Asn Glu Phe Val Ala Val Thr 370 375 380 Ser Thr Asn Ala Ala Lys Ile Phe Asn Phe Tyr Pro Arg Lys Gly Arg 385 390 395 400 Val Ala Val Gly Ser Asp Ala Asp Leu Val Ile Trp Asn Pro Lys Ala 405 410 415 Thr Lys Ile Ile Ser Ala Lys Thr His Asn Leu Asn Val Glu Tyr Asn 420 425 430 Ile Phe Glu Gly Val Glu Cys Arg Gly Ala Pro Ala Val Val Ile Ser 435 440 445 Gln Gly Arg Val Ala Leu Glu Asp Gly Lys Met Phe Val Thr Pro Gly 450 455 460 Ala Gly Arg Phe Val Pro Arg Lys Thr Phe Pro Asp Phe Val Tyr Lys 465 470 475 480 Arg Ile Lys Ala Arg Asn Arg Leu Ala Glu Ile His Gly Val Pro Arg 485 490 495 Gly Leu Tyr Asp Gly Pro Val His Glu Val Met Val Pro Ala Lys Pro 500 505 510 Gly Ser Gly Ala Pro Ala Arg Ala Ser Cys Pro Gly Lys Ile Ser Val 515 520 525 Pro Pro Val Arg Asn Leu His Gln Ser Gly Phe Ser Leu Ser Gly Ser 530 535 540 Gln Ala Asp Asp His Ile Ala Arg Arg Thr Ala Gln Lys Ile Met Ala 545 550 555 560 Pro Pro Gly Gly Arg Ser Asn Ile Thr Ser Leu Ser 565 570