NOMBRE DE SÉQUENCES : 3 INFORMATION CONCERNANT LA SEO ID NO:1 : i) CARACTRERISTIQUE DE LA SEQUENCE A) LONGUEUR : 3562 paires de base B) TYPE : acide nucléique C) NOMBRE DE BRINS : double D) CONFIGURATION : linéaire ii) TYPE DE MOLECULE : ADN vi) ORIGINE : rat ix) CARACTERISTIQUE A) NOM/CLE : ASIC B) LOCALISATION : 123 .. 1700 xi) DESCRIPTION DE LA SEQUENCE : SEQ ID NO:1 : CACACACACA CACACACACA CACACACACA CACACACACA CACACAGAAC CTGCGCCTGT 60 GCCTGTGCCT GTGCCTGTGC CTGTTTGAGA GCTGGAGACA CAGAAGGATC CCCTTGGCAA 120 GG ATG GAA TTG AAG ACC GAG GAG GAG GAG GTG GGT GGT GTC CAG CCG 167 Met Glu Leu Lys Thr Glu Glu Glu Glu Val Gly Gly Val Gln Pro 1 5 10 15 GTG AGC ATC CAG GCT TTC GCC AGC AGC TCC ACG CTG CAT GGT CTT GCC 215 Val Ser Ile Gln Ala Phe Ala Ser Ser Ser Thr Leu His Gly Leu Ala 20 25 30 CAC ATC TTC TCC TAT GAG CGG CTG TCT CTG AAG CGG GCA CTG TGG GCC 263 His Ile Phe Ser Tyr Glu Arg Leu Ser Leu Lys Arg Ala Leu Trp Ala 35 40 45 CTG TGC TTC CTG GGT TCG CTG GCC GTC CTG CTG TGT GTG TGC ACT GAG 311 Leu Cys Phe Leu Gly Ser Leu Ala Val Leu Leu Cys Val Cys Thr Glu 50 55 60 CGT GTG CAG TAC TAC TTC TGC TAT CAC CAC GTC ACC AAG CTT GAC GAA 359 Arg Val Gln Tyr Tyr Phe Cys Tyr His His Val Thr Lys Leu Asp Glu 65 70 75 GTG GCT GCC TCC CAG CTC ACC TTC CCT GCT GTC ACA CTG TGC AAT CTC 407 Val Ala Ala Ser Gln Leu Thr Phe Pro Ala Val Thr Leu Cys Asn Leu 80 85 90 95 AAT GAG TTC CGC TTT AGC CAA GTC TCC AAG AAT GAC CTG TAC CAT GCT 455 Asn Glu Phe Arg Phe Ser Gln Val Ser Lys Asn Asp Leu Tyr His Ala 100 105 110 GGG GAG CTG CTG GCC CTG CTC AAC AAC AGG TAT GAG ATC CCG GAC ACA 503 Gly Glu Leu Leu Ala Leu Leu Asn Asn Arg Tyr Glu Ile Pro Asp Thr 115 120 125 CAG ATG GCT GAT GAA AAG CAG CTA GAG ATA TTG CAG GAC AAG GCC AAC 551 Gln Met Ala Asp Glu Lys Gln Leu Glu Ile Leu Gln Asp Lys Ala Asn 130 135 140 TTC CGG AGC TTC AAG CCC AAG CCC TTC AAC ATG CGT GAA TTC TAC GAC 599 Phe Arg Ser Phe Lys Pro Lys Pro Phe Asn Met Arg Glu Phe Tyr Asp 145 150 155 AGA GCG GGG CAC GAT ATT CGA GAC ATG CTG CTC TCG TGC CAC TTC CGT 647 Arg Ala Gly His Asp Ile Arg Asp Met Leu Leu Ser Cys His Phe Arg 160 165 170 175 GGG GAG GCC TGC AGC GCT GAA GAT TTC AAA GTG GTC TTC ACT CGG TAT 695 Gly Glu Ala Cys Ser Ala Glu Asp Phe Lys Val Val Phe Thr Arg Tyr 180 185 190 GGG AAG TGT TAC ACA TTC AAC TCG GGC CAA GAT GGG CGG CCA CGG CTG 743 Gly Lys Cys Tyr Thr Phe Asn Ser Gly Gln Asp Gly Arg Pro Arg Leu 195 200 205 AAG ACC ATG AAA GGT GGG ACT GGC AAT GGC CTG GAG ATC ATG CTG GAC 791 Lys Thr Met Lys Gly Gly Thr Gly Asn Gly Leu Glu Ile Met Leu Asp 210 215 220 ATT CAG CAA GAT GAA TAT TTG CCT GTG TGG GGA GAG ACC GAC GAG ACA 839 Ile Gln Gln Asp Glu Tyr Leu Pro Val Trp Gly Glu Thr Asp Glu Thr 225 230 235 TCC TTC GAA GCA GGC ATC AAA GTG CAG ATC CAC AGT CAG GAT GAA CCC 887 Ser Phe Glu Ala Gly Ile Lys Val Gln Ile His Ser Gln Asp.Glu Pro 240 245 250 255 CCT TTC ATC GAC CAG CTG GGC TTT GGT GTG GCT CCA GGT TTC CAG ACG 935 Pro Phe Ile Asp Gln Leu Gly Phe Gly Val Ala Pro Gly Phe Gln Thr 260 265 270 TTT GTG TCT TGC CAG GAG CAG AGG CTC ATC TAC CTG CCC TCA CCC TGG 983 Phe Val Ser Cys Gln Glu Gln Arg Leu Ile Tyr Leu Pro Ser Pro Trp 275 280 285 GGC ACC TGC AAT GCT GTT ACC ATG GAC TCG GAT TTC TTC GAC TCC TAC 1031 Gly Thr Cys Asn Ala Val Thr Met Asp Ser Asp Phe Phe Asp Ser Tyr 290 295 300 AGC ATC ACT GCC TGC CGG ATT GAT TGC GAG ACG CGT TAC CTG GTG GAG 1079 Ser Ile Thr Ala Cys Arg Ile Asp Cys Glu Thr Arg Tyr Leu Val Glu 305 310 315 AAC TGC AAC TGC CGT ATG GTG CAC ATG CCA GGG GAC GCC CCA TAC TGC 1127 Asn Cys Asn Cys Arg Met Val His Met Pro Gly Asp Ala Pro Tyr Cys 320 325 330 335 ACT CCA GAG CAG TAC AAG GAG TGT GCA GAT CCT GCC CTG GAC TTC CTA 1175 Thr Pro Glu Gln Tyr Lys Glu Cys Ala Asp Pro Ala Leu Asp Phe Leu 340 345 350 GTG GAG AAA GAC CAG GAA TAC TGC GTG TGT GAG ATG CCT TGC AAC CTG 1223 Val Glu Lys Asp Gln Glu Tyr Cys Val Cys Glu Met Pro Cys Asn Leu 355 360 365 ACC CGC TAC GGC AAG GAG CTG TCC ATG GTC AAG ATC CCA AGC AAA GCC 1271 Thr Arg Tyr Gly Lys Glu Leu Ser Met Val Lys Ile Pro Ser Lys Ala 370 375 380 TCC GCC AAG TAC CTG GCC AAG AAG TTC AAC AAA TCG GAG CAG TAC ATA 1319 Ser Ala Lys Tyr Leu Ala Lys Lys Phe Asn Lys Ser Glu Gln Tyr Ile 385 390 395 GGG GAG AAC ATT CTG GTG CTG GAC ATT TTC TTT GAA GTC CTC AAC TAT 1367 Gly Glu Asn Ile Leu Val Leu Asp Ile Phe Phe Glu Val Leu Asn Tyr 400 405 410 415 GAG ACC ATC GAG CAG AAA AAG GCC TAT GAG ATC GCA GGG CTG TTG GGT 1415 Glu Thr Ile Glu Gln Lys Lys Ala Tyr Glu Ile Ala Gly Leu Leu Gly 420 425 430 GAC ATC GGG GGC CAG ATG GGG TTG TTC ATC GGT GCC AGC ATC CTC ACC 1463 Asp Ile Gly Gly Gln Met Gly Leu Phe Ile Gly Ala Ser Ile Leu Thr 435 440 445 GTG CTG GAA CTC TTT GAC TAT GCC TAC GAG GTC ATT AAG CAC AGG CTG 1511 Val Leu Glu Leu Phe Asp Tyr Ala Tyr Glu Val Ile Lys His Arg Leu 450 455 460 TGC AGA CGT GGA AAG TGC CAG AAG GAG GCT AAG AGG AGC AGC GCA GAC 1559 Cys Arg Arg Gly Lys Cys Gln Lys Glu Ala Lys Arg Ser Ser Ala Asp 465 470 475 AAG GGC GTG GCG CTC AGC CTG GAT GAC GTC AAA AGA CAC AAT CCC TGC 1607 Lys Gly Val Ala Leu Ser Leu Asp Asp Val Lys Arg His Asn Pro Cys 480 485 490 495 GAG AGC CTC CGA GGA CAT CCT GCC GGG ATG ACG TAC GCT GCC AAC ATC 1655 Glu Ser Leu Arg Gly His Pro Ala Gly Met Thr Tyr Ala Ala Asn Ile 500 505 510 CTA CCT CAC CAT CCC GCT CGA GGC ACG TTT GAG GAC TTT ACC TGC TAA 1703 Leu Pro His His Pro Ala Arg Gly Thr Phe Glu Asp Phe Thr Cys * 515 520 526 GCCCTCGCAG GCCGCTGTAC CAAAGGCCTA GGTGGGGAGG GCTGGGGGAG CAAGGGGCCC 1763 CCAACTGCCC CCAGCTACCC TGTGGACTTA ACTGCATTCC TGGTCAGTGG TTCCCTCTTG 1823 TCTGTGGTGA GAAAGGAGTC TTGACCATAG AGTCCTCTCC CAGCCTCTAT CCCATCTTTT 1943 TATTTTAATT TAATCACATT TGCTCTGTAA TATTGCTTGA GGCTGGGGAT CGTGATTTCC 2003 CCCCAGTTCT TTTATTGTTG AGAATAGTTT TCTCTATTCT GGGTTTTCTG TTATTTCAAA 2063 TGAATCTGCA AATTGCTCTT CCCATCTCTA TGAAGAATTG CGTTGGAATT TTGATGGGGA 2123 TTGTATTGAA TCTGTAGATT GCCTTTGGTA AGATGGCCAT TTTTACTATG TTAATCCTGC 2183 CAATTCATGA GCAAGGGAGA TCTTTCTATC TCTGAAATCT ACTTCAGTTT CTTTCTTCAG 2243 AGACTTGAAG TTCTTGTCAT AAAAATCTTT TTGGTTAGAG CCACACCAAG GTATTTTATA 2303 TTGTTTGTGA CTATTGTGAA TGGTGTCATT TCCCTAATTT CCTTCTCAGC CTACTTATCC 2363 TTTGAGTAGA GGAAGGCTTC TGATTTGTTT GGGTTAATTT TATACCCAGC TGCTTTGCTA 2423 AAGTTCTTTA TCAGGTTTAG GTGTTCTCTG GTGGAACTTT TGGGGTCACG TAAGAATACT 2483 ATTATATCAT CTGCAAATAG TGATATTTCA CTTCTTCCTT TCCAATTTCT ATCCCTCTGG 2543 GGACTTTTTG TTGTCTAATT GCTCTGGCTA GGACTTCAAA TTCTATATTG AATAGATAGG 2503 GAGAGAGTGG GCAGCCTTGT CTAGTTCCTG GTTTTCGTGG GATCGCTTCA AATTTCTCTC 2663 CATTTAGTTT GATATTGGCT ACTGGTTTGC TGTATATGGC TTTTACTGTA CTTAGGTATG 2723 GGCCTTGAAT TCCTGATATT TCCAAGACTT TTAACATGAA GGGGTTTTGA AATTTGCCAA 2783 ATGCTTTCTC AGCATCTAAT GAGATGATCA TGTGCCCTCC CCCCACCTTG AGTTTGTTTA 2843 TATAGTGGGT TACATGAAAG GATCATTTCT AATAGTCCAC AAGTCTGCCA AATCTTGCTG 2903 ATTGTGACTC ATTTCCATAG CAGGCTCTAT AACTTCTCTA ACAGATTGCA TTAAACTCTG 2963 CTTGGGGAAG GCATTACCTC TTGGTTGAAG CAATGTTGTA GTTTCTATGC CTGCTGAGTA 3023 AATAGCCTCA AGTCCAAGTA CTTGCCCAGA CTAATGATCA AACGTATCCA GGAGTTCCAT 3083 ACCAGAGATG TACTCTTCTC TCCTTTGAAG TACATTGCTG GAAGAGTAAT TGTGTTTGCT 3143 AGAGATACTC CTTCGAACTG CAAAAGAAAT CTCTTGGCTA AGCATATAAT CAAGCCTCAG 3203 GTTTTCTTTT TATTAAATAG CTGCTTGTAA GAAAGTGGAC ACTAAGCATA TACCTCAAAG 3263 GGAGACAGAA TGACTCTGTG CCTTCACTGA TGGAAGTCTG GGTTACAAAT TACATCAGAA 3323 GAACCTATCA TAGTGAAACA TCTCATTCCC CTGGTATAAT CCCTTCTAGA AATACACTTG 3383 TGACTCTGAA ATGTTATAAT CGTGACAACT AGGCTGTTAC AGATACACCA AGTTAAATTT 3443 GATAGAGAAA CCAGGCTTGG AGCCTCATGT CCATAGGGCA AGAGGAAGAT GCTGAGTGTT 3503 TAAGGTTGGT TTGAGCGAAG AACAATACCT TGTGTCACAA AAATGAAAGG AAAAAAGAAA 3563 AAAGGAAAGA AGGAAAGAAA GAGAGAGAAA GAAAAAGAAA GAAAGAAAAA AAAAAAAAA 3562 INFORMATION CONCERNANT LA SEO ID NO:2 i) CARACTRERISTIQUE DE LA SEQUENCE A) LONGUEUR : 1620 paires de base B) TYPE : acide nucléique C) NOMBRE DE BRINS : double D) CONFIGURATION : linéaire ii) TYPE DE MOLECULE : ADN vi) ORIGINE : homme ix) CARACTERISTIQUE A) NOM/CLE : ASIC B) LOCALISATION : 1 .. 1542 xi) DESCRIPTION DE LA SEQUENCE : SEQ ID NO:2 CCG GTG AGC ATC CAG GCC TTC GCC AGC AGC TCC ACA CTG CAC GGC ATG 48 Pro Val Ser Ile Gln Ala Phe Ala Ser Ser Ser Thr Leu His Gly Met 1 5 10 15 GCC CAC ATC TTC TCC TAC GAG CGG CTG TCT CTG AAG CGG GCA CTG TGG 96 Ala His Ile Phe Ser Tyr Glu Arg Leu Ser Leu Lys Arg Ala Leu Trp 20 25 30 GCC CTG TGC TTC CTG GGC TCG CTG GCT GTG CTG CTG TGT GTG TGC ACG 144 Ala Leu Cys Phe Leu Gly Ser Leu Ala Val Leu Leu Cys Val Cys Thr 35 40 45 GAG CGT GTG CAG TAC TAC TTC CAC TAc CAC CAT GTC ACC AAG CTC GAC 192 Glu Arg Val Gln Tyr Tyr Phe His Tyr His His Val Thr Lys Leu Asp 50 55 60 GAG GTG GCT GCC TCT CAG CTT ACC TTC CCT GCT GTC ACG CTG TGC AAC 240 Glu Val Ala Ala Ser Gln Leu Thr Phe Pro Ala Val Thr Leu Cys Asn 65 70 75 80 CTC AAC GAG TTC CGC TTT AGC CAA GTC TCC AAG AAT GAC CTG TAT CAT 288 Leu Asn Glu Phe Arg Phe Ser Gln Val Ser Lys Asn Asp Leu Tyr His 85 90 95 GCT GGG GAG CTG CTG GCC CTG CTC AAC AAC AGG TAT GAG ATA CCA GAC 336 Ala Gly Glu Leu Leu Ala Leu Leu Asn Asn Arg Tyr Glu Ile Pro Asp 100 105 110 ACA CAG ATG GCA GAT GAA AAG CAG CTG GAG ATA CTG CAG GAC AAA GCC 384 Thr Gln Met Ala Asp Glu Lys Gln Leu Glu Ile Leu Gln Asp Lys Ala 115 120 125 AAC TTC CGC AGC TTC AAA CCC AAA CCC TTC AAC ATG CGT GAG TTC TAC 432 Asn Phe Arg Ser Phe Lys Pro Lys Pro Phe Asn Met Arg Glu Phe Tyr 130 135 140 GAC CGA GCT GGG CAC GAC ATT CGA GAC ATG CTG CTC TCC TGC CAC TTC 480 Asp Arg Ala Gly His Asp Ile Arg Asp Met Leu Leu Ser Cys His Phe 145 150 155 160 CGG GGG GAG GTC TGC AGC GCT GAA GAC TTC AAG GTG GTC TTC ACA CGC 528 Arg Gly Glu Val Cys Ser Ala Glu Asp Phe Lys Val Val Phe Thr Arg 165 170 175 TAT GGA AAG TGC TAC ACG TTC AAC TCG GGC CGA AAT GGG CGG CCG CGG 576 Tyr Gly Lys Cys Tyr Thr Phe Asn Ser Gly Arg Asn Gly Arg Pro Arg 180 185 190 CTG AAG ACC ATG AAG GGT GGG ACG GGC AAT GGG CTG GAA ATC ATG CTG 624 Leu Lys Thr Met Lys Gly Gly Thr Gly Asn Gly Leu Glu Ile Met Leu 195 200 205 GAC ATC CAG CAG GAC GAG TAC CTG CCT GTG TGG GGG GAG ACT GAC GAG 672 Asp Ile Gln Gln Asp Glu Tyr Leu Pro Val Trp Gly Glu Thr Asp Glu 210 215 220 ACG TCT TTC GAA GCA GGC ATC AAA GTG CAG ATC CAT AGT CAG GAT GAA 720 Thr Ser Phe Glu Ala Gly Ile Lys Val Gln Ile His Ser Gln Asp Glu 225 230 235 240 CCT CCT TTC ATC GAC CAG CTG GGC TTT GGC GTG GCC CCA GGC TTC CAG 768 Pro Pro Phe Ile Asp Gln Leu Gly Phe Gly Val Ala Pro Gly Phe Gln 245 250 255 ACC TTT GTG GCC TGC CAG GAG CAG CGG CTC ATA TAC CTG CCC CCA CCC 816 Thr Phe Val Ala Cys Gln Glu Gln Arg Leu Ile Tyr Leu Pro Pro Pro 260 265 270 TGG GGC ACC TGC AAA GCT GTT ACC ATG GAC TCG GAT TTG GAT TTC TTC 864 Trp Gly Thr Cys Lys Ala Val Thr Met Asp Ser Asp Leu Asp Phe Phe 275 280 285 GAC TCC TAC AGC ATC ACT GCC TGC CGC ATC GAC TGT GAG ACG CGC TAC 912 Asp Ser Tyr Ser Ile Thr Ala Cys Arg Ile Asp Cys Glu Thr Arg Tyr 290 295 300 CTG GTG GAG AAC TGC AAC TGC CGC ATG GTG CAC ATG CCA GGG GAT GCC 960 Leu Val Glu Asn Cys Asn Cys Arg Met Val His Met Pro Gly Asp Ala 305 310 315 320 CCA TAC TGT ACT CCA GAG CAG TAC AAG GAG TGT GCA GAT CCT GCT CTG 1008 Pro Tyr Cys Thr Pro Glu Gln Tyr Lys Glu Cys Ala Asp Pro Ala Leu 325 330 335 GAC TTC CTG GTG GAG AAG GAC CAG GAG TAC TGC GTG TGT GAA ATG CCT 1056 Asp Phe Leu Val Glu Lys Asp Gin Glu Tyr Cys Val Cys Glu Met Pro 340 345 350 TGC AAC CTG ACC CGC TAT GGC AAA GAG CTG TCC ATG GTC AAG ATC CCC 1104 Cys Asn Leu Thr Arg Tyr Gly Lys Glu Leu Ser Met Val Lys Ile Pro 355 360 365 AGC AAA GCC TCA GCC AAG TAC CTG GCC AAG AAG TTC AAC AAA TCT GAG 1152 Ser Lys Ala Ser Ala Lys Tyr Leu Ala Lys Lys Phe Asn Lys Ser Glu 370 375 380 CAA TAC ATA GGG GAG AAC ATC CTG GTG CTG GAC ATT TTC TTT GAA GTC 1200 Gln Tyr Ile Gly Glu Asn Ile Leu Val Leu Asp Ile Phe Phe Glu Val 385 390 395 400 CTC AAC TAT GAG ACC ATT GAA CAG AAG AAG GCC TAT GAG ATT GCA GGG 1248 Leu Asn Tyr Glu Thr Ile Glu Gln Lys Lys Ala Tyr Glu Ile Ala Gly 405 410 415 CTC CTG GGT GAC ATC GGG GGC CAG ATG GGG CTG TTC ATC GGG GCC AGC 1296 Leu Leu Gly Asp Ile Gly Gly Gln Met Gly Leu Phe Ile Gly Ala Ser 420 425 430 ATC CTC ACG GTG CTG GAG CTC TTT GAC TAC GCC TAC GGG GTC ATT AAG 1344 Ile Leu Thr Val Leu Glu Leu Phe Asp Tyr Ala Tyr Gly Val Ile Lys 435 440 445 CAC AAG CTG TGC CGA CGA GGA AAA TGC CAG AAG GAG GCC AAA AGG AGC 1392 His Lys Leu Cys Arg Arg Gly Lys Cys Gln Lys Glu Ala Lys Arg Ser 450 455 460 AGT GCG GAC AAG GGC GTG GCC CTC AGC CTG GAC GAC GTC AAA AGA CAC 1440 Ser Ala Asp Lys Gly Val Ala Leu Ser Leu Asp Asp Val Lys Arg His 465 470 475 480 AAC CCG TGC GAG AGC CTT CGG GGC CAC CCT GCC GGG ATG ACA TAC GCT 1488 Asn Pro Cys Glu Ser Leu Arg Gly His Pro Ala Gly Met Thr Tyr Ala 485 490 495 GCC AAC ATC GTA CCT CAC CAT CCG GCC CGA GGC ACG TTC GAG GAC TTT 1536 Ala Asn Ile Val Pro His His Pro Ala Arg Gly Thr Phe Glu Asp Phe 500 505 510 ACC TGC TGA GCCCCGCAGG CCGCCGAACC AAAGACCTAG ATGGGGAGGA CTAGGAGAGC 1595 Thr Cys * 514 GAGGGGGCCC CCAGCTGCCT CCTAA 1620 INFORMATION CONCERNANT LA SEO ID NO:3 i) CARACTRERISTIQUE DE LA SEQUENCE A) LONGUEUR : 1666 paires de base B) TYPE : acide nucléique C) NOMBRE DE BRINS : double D) CONFIGURATION : linéaire ii) TYPE DE MOLECULE : ADN vi) ORIGINE : homme ix) CARACTERISTIQUE A) NOM/CLE : MDEG B) LOCALISATION : 127 .. 1663 xi) DESCRIPTION DE LA SEQUENCE : SEQ ID NO:3 TCTGGCGCGA TGCTTACCTT GCGTTCTCTC CCCTGAACGT CAAGGTTTAA GCAGAGCCCG 60 AGGACTGGGA GCTCTTCTCT GAAATTCGAT CAACCTGAAG CCAGTTGCGG AACTGCACGG 120 GGTCCCG ATG GAC CTC AAG GAA AGC CCC AGT GAG GGC AGC CTG CAA CCT 169 Met Asp Leu Lys Glu Ser Pro Ser Glu Gly Ser Leu Gln Pro 1 5 10 TCT AGC ATC CAG ATC TTT GCC AAC ACC TCC ACC CTC CAT GGC ATC CGC 217 Ser Ser Ile Gln Ile Phe Ala Asn Thr Ser Thr Leu His Gly Ile Arg 15 20 25 30 CAC ATC TTC GTG TAT GGG CCG CTG ACC ATC CGG CGT GTG CTG TGG GCA 265 His Ile Phe Val Tyr Gly Pro Leu Thr Ile Arg Arg Val Leu Trp Ala 35 40 45 GTG GCC TTC GTG GGC TCT CTG GGC CTG CTG CTG GTG GAG AGC TCT GAG 313 Val Ala Phe Val Gly Ser Leu Gly Leu Leu Leu Val Glu Ser Ser Glu 50 55 60 AGG GTG TCC TAC TAC TTC TCC TAC CAG CAT GTC ACT AAG GTG GAC GAA 361 Arg Val Ser Tyr Tyr Phe Ser Tyr Gln His Val Thr Lys Val Asp Glu 65 70 75 GTG GTG GCT CAA AGC CTG GTC TTC CCA GCT GTG ACC CTC TGT AAC CTC 409 Val Val Ala Gln Ser Leu Val Phe Pro Ala Val Thr Leu Cys Asn Leu 80 85 90 AAT GGC TTC CGG TTC TCC AGG CTC ACC ACC AAC GAC CTG TAC CAT GCT 457 Asn Gly Phe Arg Phe Ser Arg Leu Thr Thr Asn Asp Leu Tyr His Ala 95 100 105 110 GGG GAG CTG CTG GCC CTG CTG GAT GTC AAC CTG CAG ATC CCG GAC CCC 505 Gly Glu Leu Leu Ala Leu Leu Asp Val Asn Leu Gln Ile Pro Asp Pro 115 120 125 CAT CTG GCT GAC CCC TCC GTG CTG GAG GCC CTG CGG CAG AAG GCC AAC 553 His Leu Ala Asp Pro Ser Val Leu Glu Ala Leu Arg Gln Lys Ala Asn 130 135 140 TTC AAG CAC TAC AAA CCC AAG CAG TTC AGC ATG CTG GAG TTC CTG CAC 601 Phe Lys His Tyr Lys Pro Lys Gln Phe Ser Met Leu Glu Phe Leu His 145 150 155 CGT GTG GGC CAT GAC CTG AAG GAT ATG ATG CTC TAC TGC AAG TTC AAA 649 Arg Val Gly His Asp Leu Lys Asp Met Met Leu Tyr Cys Lys Phe Lys 160 165 170 GGG CAG GAG TGC GGC CAC CAA GAC TTC ACC ACA GTG TTT ACA AAA TAT 697 Gly Gln Glu Cys Gly His Gln Asp Phe Thr Thr Val Phe Thr Lys Tyr 175 180 185 190 GGG AAG TGT TAC ATG TTT AAC TCA GGC GAG GAT GGC AAA CCT CTG CTC 745 Gly Lys Cys Tyr Met Phe Asn Ser Gly Glu Asp Gly Lys Pro Leu Leu 195 200 205 ACC ACG GTC AAG GGG GGG ACA GGC AAC GGG CTG GAG ATC ATG CTG GAC 793 Thr Thr Val Lys Gly Gly Thr Gly Asn Gly Leu Glu Ile Met Leu Asp 210 215 220 ATT CAG CAG GAT GAG TAC CTG CCC ATC TGG GGA GAG ACA GAG GAA ACG 841 Ile Gln Gln Asp Glu Tyr Leu Pro Ile Trp Gly Glu Thr Glu Glu Thr 225 230 235 ACA TTT GAA GCA GCA GTG AAA GTT CAG ATC CAC AGT CAG TCT GAG CCA 889 Thr Phe Glu Ala Gly Val Lys Val Gln Ile His Ser Gln Ser Glu Pro 240 245 250 CCT TTC ATC CAA GAG CTG GGC TTT GGG GTG GCT CCA GGG TTC CAG ACC 937 Pro Phe Ile Gln Glu Leu Gly Phe Gly Val Ala Pro Gly Phe Gln Thr 255 260 265 270 TTT GTG GCC ACA CAG GAG CAG AGG CTC ACA TAC CTG CCC CCA CCG TGG 985 Phe Val Ala Thr Gln Glu Gln Arg Leu Thr Tyr Leu Pro Pro Pro Trp 275 280 285 GGT GAG TGC CGA TCC TCA GAG ATG GGC CTC GAC TTT TTT CCT GTT TAC 1033 Gly Glu Cys Arg Ser Ser Glu Met Gly Leu Asp Phe Phe Pro Val Tyr 290 295 300 AGC ATC ACC GCC TGT AGG ATT GAC TGT GAG ACC CGC TAC ATT GTG GAA 1081 Ser Ile Thr Ala Cys Arg Ile Asp Cys Glu Thr Arg Tyr Ile Val Glu 305 310 315 AAC TGC AAC TGC CGC ATG GTT CAC ATG CCA GGG GAT GCC CCT TTT TGT 1129 Asn Cys Asn Cys Arg Met Val His Met Pro Gly Asp Ala Pro Phe Cys 320 325 330 ACC CCT GAG CAG CAC AAG GAG TGT GCA GAG CCT GCC CTA GGT CTG TTG 1177 Thr Pro Glu Gln His Lys Glu Cys Ala Glu Pro Ala Leu Gly Leu Leu 335 340 345 350 GCG GAA AAG GAC AGC AAT TAC TGT CTC TGC AGG ACA CCC TGC AAC CTA 1225 Ala Glu Lys Asp Ser Asn Tyr Cys Leu Cys Arg Thr Pro CyS Asn Leu 355 360 365 ACC CGC TAC AAC AAA GAG CTC TCC ATG GTG AAG ATC CCC AGC AAG ACA 1273 Thr Arg Tyr Asn Lys Glu Leu Ser Met Val Lys Ile Pro Ser Lys Thr 370 375 380 TCA GCC AAG TAC CTT GAG AAG AAA TTT AAC AAA TCA GAA AAA TAT ATC 1321 Ser Ala Lys Tyr Leu Glu Lys Lys Phe Asn Lys Ser Glu Lys Tyr Ile 385 390 395 TCA GAG AAC ATC CTT GTT CTG GAT ATA TTT TTT GAA GCT CTC AAT TAT 1369 Ser Glu Asn Ile Leu Val Leu Asp Ile Phe Phe Glu Ala Leu Asn Tyr 400 405 410 GAG ACA ATT GAA CAG AAG AAG GCG TAT GAA GTT GCT GCC TTA CTT GGT 1417 Glu Thr Ile Glu Gln Lys Lys Ala Tyr Glu Val Ala Ala Leu Leu Gly 415 420 425 430 GAT ATT GGT GGT CAG ATG GGA TTG TTC ATT GGT GCT AGT ATC CTT ACA 1465 Asp Ile Gly Gly Gln Met Gly Leu Phe Ile Gly Ala Ser Ile Leu Thr 435 440 445 ATA CTA GAG CTC TTT GAT TAT ATT TAT GAG CTG ATC AAA GAG AAG CTA 1513 Ile Leu Glu Leu Phe Asp Tyr Ile Tyr Glu Leu Ile Lys Glu Lys Leu 450 455 460 TTA GAC CTG CTT GGC AAA GAG GAG GAT GAA GGG AGC CAC GAT GAG AAT 1561 Leu Asp Leu Leu Gly Lys Glu Glu Asp Glu Gly Ser His Asp Glu Asn 465 470 475 GTG AGT ACT TGT GAC ACA ATG CCA AAC CAC TCT GAA ACC ATC AGT CAC 1609 Val Ser Thr Cys Asp Thr Met Pro Asn His Ser Glu Thr Ile Ser His 480 485 490 ACT GTG AAC GTG CCC CTG CAG ACG ACC CTG GGG ACC CTG GAA GAA ATA 1657 Thr Val Asn Val Pro Leu Gln Thr Thr Leu Gly Thr Leu Glu Glu Ile 495 500 505 510 GCC TGC TGA 1666 Ala Cys * 512