TABLEAU 1 : Epitopes de BCR-ABL Peptide Séquence Fixation au HLA 247-255 EDAELNPRF B44 488-496 SELDLEKGL B44.768-776 DELEAVPNI B44 903-934 b2a2 KEDALQRPV B44 902-935 b2a2 EDALQRPVA B44 986-994 GEKLRVLGY B44 1176-1184 EDTMEVEEF B44 1252-1260 MEYLEKKNF B44 1691-1699 NEEAADEVF B44 49-57 VNQERFRMI B8 580-588 LFQKLASQL B8 720-730 ARKLRHVFL B8 786-794 ALKIKISQI B8 886-893 CVKLQTVH B8 928-936 b3a2 KALQRPVAS B8 1830-1838 GAKTKATSL B8 1975-1983 IQQMRNKFA B8 1977-1984 QMRNKFAF B8 252-260 NPRFLDNL B7 329-338 TPDCSSNENL B7 693-701 TPRRQSMTV B7 1058-1066 SPGQRSISL B7 1195-1205 HPNLVQLLGV B7 1560-1569 SPKPSNGAGV B7 1717-1725 KPLRRQVTV B7 1878-1884 SPAPVPSTL B7 36-44 ERCKASIRR B27 71-79 DRQRWGFFRR B27 575-583 QRVGDLFQK B27 834-842 FRVHSRNGK B27 642-650 LLYKPVDRV A2 684-692 FLSSINEEI A2 708-716 QLLKDSFMV A2 714-722 FMVELVEGA A2 817-825 KLSEQESLL A2 881-889 MLTNSCVKL A2 908-917 GLYGFLNVIV A2 912-920 FLNVIVHSA A2 1240-1248 VLLYMATQI A2 1903-1911 FIPLSTRV A2 1932-1940 VVLDSTEAL A2 50-58 NQERFRMIY A1 223-231 VGDASRPPY A1 549-558 KVPELYEIHK A3/A11 583-591 KLASQLGVY A3/A11 715-724 MVELVEGARK A3/A11 916-923 IVHSTGFK A3/A11 920-928 b3a2 ATGFKQSSK A3/A11 924-932 b3a2 KQSSKALQR A3/A11 1156-1165 EVYEGVWKKY A3/A11 1311-1320 SLAYNKFSIK A3/A11 1499-1509 NLFSALIKK A3/A11 1724-1734 TVAPASGLPHK A3/A11 1905-1914 LISTRVSLRK A3/A11 1922-1930 RIASGAITK A3/A11 924-936 b3a2 KQSSKALQRPVAS OR4 TABLEAU 2 - Epitopes de la p53 - épitopes de la p53 se liant au HLA-A1: RVEGNLARVEY (196-205) GSDCTTIHY (226-234) - épitopes de la p53 se liant au HLA-A2: LLPENNVLSPL (25-35) RMPEAAPPV (65-73) RMPEAAPRV ALNKMFCQL (129-137) STPPPGTRV (149-157) GLAPPQHLIRV (187-197) LLGRNSFEV (264-272) PLDGEYFTL (322-330) - épitopes de la p53 se liant au HLA-A3: RVRAMAIYK (156-164) RRTEEENLR (282-290) ELPPGSTKR (298-306) - épitopes de la p53 se liant au HLA-B7: LPENNVLSPL (26-35) APRMPEAAPPV (63-73) APRMPEAAPRV APPQHLIRV (189-197) RPILTIITL (249-257) KPLDGETYFTL (321-330) - épitopes de la p53 se liant au HLA-B8: CQLAKTCPV (135-143) GLAPPQHLl (187-195) NTFRHSVVV (210-218) - épitopes de la p53 se liant au HLA-B51: LLPENNVLSPL (25-35) RMPEAAPPV (65-73) LIRVEGNLRV (194-203) TABLEAU 3 Epitopes des protéines Eh et E7 YMLDLQPETT (E7 11-20) LLMGTLGIV (E7 82-90) TLGIVCPI (E7 86-93) TIHDIILECV (E6 29-38) KLPQLCTEL (E6 18-26) RPPKLPQL (E6 8-15) LRREVYDFAFRDLCIVYRDGNPY (E6 45-67) ISEYRHYCY (E6 80-88) EKQRHLDKKQRFHNIRGRWT (E6 121-140) GQAEPDRAHYNIVTF (E7 43-57) QAEPDRAHY (E7 44-52) EPDRAHYNIV (E7 46-55) TABLEAU 4 : Epitopes du vitûs VIH-1 HLA-A1 (Nef 96-106: GLEGLIHSQRR (Nef 121-128: FPDWQNYT (Nef 137-145: LTFGWCYKL (Nef 184-191: RFDSRLAF (Nef 195-202: ARELHPEY HLA-A2 Gp120 121-129: KLTPLCVTL P17 77-85: SLYNTVATL RT 200-208: ALVEICTEM RT 275-285: VLDVGDAYFSV RT 346-354: KIYQYMDDL RT 368-376: KIEELRQHL RT 376-387: LLRWGLTTPDK RT 476-484: ILKEPVHGV RT 588-596: PLVKLWYQL RT 683-692: ELVNQHEQL, Nef 136-145: PLTFGWCFKL Nef 180-189: VLQWRFDSRL Nef 190-198: ALHVAREL Gp41 818-826: SLLNATVDI P24 185-193: DLNTMLNTV RT 346-354: VIYQYMDDL RT 588-596: PLVKLWYQL Pro 143-152: VLVGPTPVNI (Gp120 37-44: TVYYGVPV (Gp120 115-122: SLKPCVKL (Gp120 313-321: RIQRGPGRA (Gp120 197-205: TLTSCNTSV (Gp120 428-435: FINMWQEV (Gp41 836-844: VVQGAYRAI (p24 219-228: HAGPIAPGQM (p15 422-431: QMKDCTERQA (p15 448-456: FLQSRPETA (RT 681-691: ESELVNQHEG HLA-A3 P17 18-26: KIRLRPGGK P17 20-28: RLRPGGKKK@ RT 200-210: ALVEICTEMEK RT 325-333: AIFQSSMTK RT359-368: DLEIGQHRTK Nef 73-82: QVPLRPMTYK @ Gp120 37-46: TVYYGVPVWK Gp41 775-785: RLRDLLLIVTR P17 18-26: KIRLRPGGK HLA-A11 RT 325-333: AJFQSSMTK RT 507-517: QIYQFPFKNLK Nef 73-82: QVPLRPMTYK Nef 84-92: AVDLSHFLK p24 349-359: ACQVGGPGHK P17 83-91: ATLYCVHQR Tableau 4 (suite) HLA-A24 (A9) Gp120 52-61: LFCASDAKAY Gp41 591-598: YLKDQQLL ou 590-597: RYLKDQQLL (RT 482-492: VYYD (RT 508-516: IYQEPFKNL (RT 681-691: ESELVNQHEG HLA-A25(A10) P24 203-212: ETINEEAAEW HLA-A26(A10) P24 167-175: EVIPMFSAL HLA-A30(A19) (Gp41 845-852: RAIRHIPRR HLA-A31(A19) Gp41 75-/85 : RLRDLLLIVTR HLA-A32(A19) Gp120 424-432: RIKQHNMW Gp41 774-785: HRLRDLLLI@ RT 559-568: PIQKETWETW HLA-A33(A19) (P24 266-275: HLGLNKIVR HLA-B7 RT 699-707: YLAWVPAHK Nef 68-77: FPVTQVPLR Nef 128-137: TPGPGVRYPL Gp120 303-312: RRNNNTRKSI Gp41 848-856: IPRRIRQGL RT 699-707: YLAWVPAHK HLA-B8 Gp120 2-10: RVKEKYQHL P17 24-32: GGKKKYKLK Nef 90-97: FLKEKGGL = P24 259-267: GETYKRWH Gp41 591-598: YLKDQQLL (Gp41 849-856: PRRIRQGL ou 851-859: RIRQGLERIL (P24 329-337: DCKTILKAL (RT 185-193: GPKVKQWPL (Nef 182-189: EWRFDSRL @ HLA-B14 Gp41 589-597: ERYLKDQQL P24 298-306: DRFYKTLRA (P24 183-191 ? : -191 ? : DLNTMLNTV (p24 304-313: LRAEQASVQEV (p24 305-313: RAEQASVQEV HLA-B18 Nef 135-143: YPLTFGWCY Nef 135-143: YPLTFGWCF Tableau 4 (suite) HLA-B27 P24 263-272: KRWTILGLNK Nef 73-82: QVPLRPMTYK Nef 134-141: RYPLTFGW ou 133-141: YPLTFGW Gp41 589-597: ERYLKDQQL (Gp41 791-800: GRRGWEALKY HLA-B35 Gp120 78-86: DPNPQEVVL Gp120 257-265: RPVVSTQLL RT 285-294: VPLDKDFRKY RT 323-331: SPAIFQSSM : RT 342-350: NPDIVIYQY (consensus clade B) RT 460-468: IPLTEEAEL RT 598-608: EPIVGAETFY Nef 68-76: FPVRPQVPL Nef 74-81: VPLRPMTY Gp41 611-619: TAVPWNASW Gp120 42-52: VPVWKEATTTL P17 124-132: NSSQVSQNY (consensus clade B) P24 254-262: PPIPVGEIY (consensus clade B) HLA-B37 Nef 120-128: YFPDWQNYT HLA-B44 (B12) P24 178-186: SEGATPQDL (p24 175-184: LESGATPQDL HLA-B51 (B5) gp41 562-570: RAIEAQQHL RT 200-208: ALVEICTEM RT 209-217: EKEGKISKI RT 295-302: TAFTIPSI HLA-B52 (B5) Nef 190-198: AFHHVAREL HLA-B55 (B22) Gp120 42-51: VPVWKEATTTL HLA-B57 et B58 (B17) P24 240-249: TSLTQEQIGW Nef 116-125: HTQGYFPDWQ ou 116-124: HTQGYFPDW Nef 120-128: YFPDWQN (P24 147-155: ISPRTLNAW (P24 164-172: FSPEVIPMF HLA-Bw62 (B15) P17 20-29: RLRPGGKKKY P24 268-277: LGLNKIVRMY RT 427-438: LVGKLNWASQIY Nef 84-91: AVDLSHFL Nef 117-127: TQGYFPDWQNY Tableau4(suite) HLA-Cw4 gp120 380-388: SFNCGGEFF HLA-Cw8 RT 663-672: VTDSQYALGI: P24 305-313: RAEQASQEV Nef 82-91: KAALDLSHPL HLA-Cw? P24 308-316: QATQEVKNW TABLEAU 5 - Epitopes de Mélanome humain