(ix) PARTICULARITE (A) NOM/CLE : misc feature (B) LOCALISATION : 205..217 (D) AUTRES INFORMATIONS : /note = "Les nucléotides 205 et 217 passent de T à G par comparaison à la séquence de type sauvage" (xi) DESCRIPTION DE LA SEQUENCE SEQ ID NO:22 CATCTCTTTA ATTTGTGAAT TTCAATTCAT CGGAACCTGT TO ATG GAC ACC ACC 54 Met Asp Thr Thr ATT GAT GGA TTC GCC GAT TCT TAT GAA ATC AGC AGC ACT AGT TTC GTC 102 Ile Asp Gly Phe Ala Asp Ser Tyr Glu Ile Ser Ser Thr Ser Phe Val 5 10 15 20 GCT ACC GAT AAC ACC GAC TCC TCT ATT GTT TAT CTG GCC GCC GAA CAA 150 Ala Thr Asp Asn Thr Asp Ser Ser Ile Val Tyr Leu Ala Ala Glu Gln 25 30 35 GTA CTC ACC GGA CCT GAT GTA TCT GCT CTG CAA TTG CTC TCC AAC AGC 198 Val Leu Thr Gly Pro Asp Val Ser Ala Leu Gln Leu Leu Ser Asn Ser 40 45 50 TTC GAA GCC GTC TTT GAC CCC CCG GAT GAT TTC TAC AGC GAC GCT AAG 246 Phe Glu Ala Val Phe Asp Ala Pro Asp Asp Phe Tyr Ser Asp Ala Lys 55 60 65 CTT GTT CTC TCC GAC GGC CGG GAA GTT TCT TTC CAC CGG TGC GTT TTG 294 Leu Val Leu Ser Asp Gly Arg Glu Val Ser Phe His Arg Cys Val Leu 70 75 80 TCA CCC AGA AGC TCT TTC TTC AAC AGC GCT TTA GCC GCC GCT AAC AAC 342 Ser Ala Arg Ser Ser Phe Phe Lys Ser Ala Leu Ala Ala Ala Lys Lys 85 90 95 100 GAG AAA GAC TCC AAC AAC ACC GCC GCC GTG AAC CTC GAG CTT AAG GAG 390 Glu Lys Asp Ser Asn Asn Thr Ala Ala Val Lys Leu Glu Leu Lys Glu 105 110 115 ATT CCC AAC GAT TAC GAA GTC GGT TTC GAT TCC GTT GTG ACT GTT TTG 438 Ile Ala Lys Asp Tyr Glu Val Gly Phe Asp Ser Val Val Thr Val Leu 120 125 130 GCT TAT GTT TAC AGC AGC AGA GTG AGA CCG CCG CCT AAA GGA GTT TCT 486 Ala Tyr Val Tyr Ser Ser Arg Val Arg Pro Pro Pro Lys Gly Val Ser 135 140 145 GAA TGC GCA GAC GAG AAT TGC TGC CAC GTG GCT TGC CGG CCC CCC GTG 534 Clu Cys Ala Asp Glu Asn Cys Cys His Val Ala Cys Arg Pro Ala Val 150 155 160 GAT TTC ATG TTG GAG GTT CTC TAT TTG GCT TTC ATC TTC AAG ATC CCT 582 Asp Phe Met Leu Glu Val Leu Tyr Leu Ala Phe Ile Phe Lys Ile Pro 165 170 175 180 GAA TTA ATT ACT CTC TAT CAG AGG CAC TTA TTG GAC CTT GTA GAC AAA 630 Glu Leu Ile Thr Leu Tyr Gln Arg His Leu Leu Asp Val Val Asp Lys 185 190 195 GTT GTT ATA GAG GAC ACA TTG GTT ATA CTC AAG CTT GCT AAT ATA TCT 678 Val Val Ile Glu Asp Thr Leu Val Ile Leu Lys Leu Ala Asn Ile cys 200 205 210 GGT AAA GCT TCT ATG AAC CTA TTG GAT AGA TGT AAA GAG ATT ATT GTC 726 Gly Lys Ala cys Met Lys Leu Leu Asp Arg Cys Lys Glu Ile Ile Val 215 220 225 AAG TCT AAT GTA GAT ATG GTT AGT CTT GAA AAG TCA TTC CCC GAA GAG 774 Lys Ser Asn Val Asp Met Val Ser Leu Glu Lys Ser Leu Pro Glu Glu 230 235 240 CTT GTT AAA GAG ATA ATT GAT AGA CGT AAA GAG CTT GGT TTG GAG GTA 822 Leu Val Lys Glu Ile Ile Asp Arg Arg Lys Glu Leu Gly Leu Glu Val 245 250 255 260 CCT AAA GTA AAG AAA CAT GTC TCC AAT GTA CAT AAG GCA CTT GAC TCG 870 Pro Lys Val Lys Lys His Val Ser Asn Val His Lys Ala Leu Asp Ser 265 270 275 GAT GAT ATT GAG TTA CTC AAC TTG CTT TTG AAA GAG GAT CAC ACC AAT 918 Asp Asp Ile Glu Leu Val Lys Leu Leu Leu Lys Glu Asp His Thr Asn 280 285 290 CTA GAT GAT CCC TGT GCT CTT CAT TTC GCT GTT GCA TAT TGC AAT GTG 966 Leu Asp Asp Ala Cys Ala Leu His Phe Ala Val Ala Tyr Cys Asn Val 295 300 305 AAG ACC GCA ACA GAT CTT TTA AAA CTT GAT CTT GCC GAT GTC AAC CAT 1014 Lys Thr Ala Thr Asp Leu Leu Lys Leu Asp Leu Ala Asp Val Asn His 310 315 320 AGG AAT CCG AGG GGA TAT ACC GTG CTT CAT GTT GCT GCG ATG CGC AAG 1062 Arg Asn Pro Arg Gly Tyr Thr Val Leu His Val Ala Ala Met Arg Lys 325 330 335 340 GAG CCA CAA TTC ATA CTA TCT CTA TTG GAA AAA GGT GCA AGT GCA TCA 1110 Glu Pro Gln Leu Ile Leu Ser Leu Leu Glu Lys Gly Ala Ser Ala Ser 345 350 355 GAA GCA ACT TTG GAA GGT AGA ACC GCA CTC ATG ATC GCA AAA CAA GCC 1158 Glu Ala Thr Leu Glu Gly Arg Thr Ala Leu Met Ile Ala Lys Gln Ala 360 365 370 ACT ATG CCC GTT GAA TGT AAT AAT ATC CCG GAG CAA TGC AAG CAT TCT 1206 Thr Met Ala Val Glu Cys Asn Asn Ile Pro Glu Gln Cys Lys His Ser 375 380 385 CTC AAA GGC CGA CTA TGT GTA GAA ATA CTA GAG CAA GAA GAC AAA CGA 1254 Leu Lys Gly Arg Leu Cys Val Glu Ile Leu Glu Gln Glu Asp Lys Arg 390 395 400 GAA CAA ATT CCT AGA GAT GTT CCT CCC TCT TTT GCA GTC GCG GCC GAT 1302 Glu Gln Ile Pro Arg Asp Val Pro Pro Ser Phe Ala Val Ala Ala Asp 405 410 415 420 GAA TTG AAG ATG ACG CTG CTC GAT CTT GAA AAT AGA GTT GCA CTT GCT 1350 Glu Leu Lys Met Thr Leu Leu Asp Leu Glu Asn Arg Val Ala Leu Ala 425 430 435 CAA CGT CTT TTT CCA ACG GAA GCA CAA GCT GCA ATG GAG ATC GCC GAA 1398 Gln Arg Leu Phe Pro Thr Glu Ala Gln Ala Ala Met Glu Ile Ala Glu 440 445 450 ATG AAC GGA ACA TGT GAG TTC ATA GTG ACT AGC CTC GAG CCT GAC CGT 1446 Met Lys Gly Thr Cys Glu Phe Ile Val Thr Ser Leu Glu Pro Asp Arg 455 460 465 CTC ACT GGT ACG AAG AGA ACA TCA CCC GGT GTA AAC ATA GCA CCT TTC 1494 Leu Thr Gly Thr Lys Arg Thr Ser Pro Gly Val Lys Ile Ala Pro Phe 470 475 480 AGA ATC CTA GAA GAG CAT CAA AGT AGA CTA AAA GCG CTT TCT AAA ACC 1542 Arg Ile Leu Glu Glu His Gln Ser Arg Leu Lys Ala Leu Ser Lys Thr 485 490 495 500 GTG GAA CTC GGG AAA CGA TTC TTC CCG CCC TGT TCG GCA GTG CTC GAC 1590 Val Glu Leu Gly Lys Arg Phe Phe Pro Arg Cys Ser Ala Val Leu Asp 505 510 515 CAG ATT ATG AAC TGT GAG GAC TTG ACT CAA CTC GCT TGC GGA GAA GAC 1638 Gln Ile Met Asn Cys Glu Asp Leu Thr Gln Leu Ala Cys Gly Glu Asp 520 525 530 GAC ACT GCT GAG AAA CGA CTA CAA AAG AAG CAA AGG TAC ATG GAA ATA 1686 Asp Thr Ala Glu Lys Arg Leu Gln Lys Lys Gln Arg Tyr Met Glu Ile 535 540 545 CAA GAG ACA CTA AAG AAG GCC TTT AGT GAG GAC AAT TTG GAA TTA GCA 1734 Gln Glu Thr Leu Lys Lys Ala Phe Ser Glu Asp Asn Leu Glu Leu Gly 550 555 560 AAT TTG TCC CTG ACA GAT TCC ACT TCT TCC ACA TCG AAA TCA ACC GGT 1782 Asn Leu Ser Leu Thr Asp Ser Thr Ser Ser Thr Ser Lys Ser Thr Gly 565 570 575 580 GGA AAC AGG TCT AAC CGT AAA CTC TCT CAT CGT CGT CGG TGA 1824 Gly Lys Arg Ser Asn Arg Lys Leu Ser His Arg Arg Arg 585 590 GACTCTTGCC TCTTAGTGTA ATTTTTGCTG TACCATATAA TTCTGTTTTC ATGATGACTG 1884 TAACTGTTTA TGTCTATCGT TGGCGTCATA TAGTTTCGCT CTTCGTTTTG CATCCTGTGT 1944 ATTATTGCTG CAGGTGTGCT TCAAACAAAT GTTGTAACAA TTTGAACCAA TGGTATACAG 2004 ATTTGTA 2011 (2) INFORMATIONS POUR LA SEQUENCE SEQ ID NO:23 (i) CARACTERISTIQUES DE LA SEQUENCE (A) LONGUEUR : 594 acides aminés (B) TYPE : acide aminé (D) TOPOLOGIE : linéaire (xi) DESCRIPTION DE LA SEQUENCE SEQ ID NO:23 Met Asp Thr Thr Ile Asp Cîy Phe Ala Asp Ser Tyr Glu Ile Ser Ser 1 5 10 15 Thr Ser Phe Val Ala Thr Asp Asn Thr Asp Ser Ser Ile Val Tyr Leu 20 25 30 Ala Ala Glu Gln Val Leu Thr Gly Pro Asp Val Ser Ala Leu Cln Leu 35 40 45 Leu Ser Asn Ser Phe Glu Ala Val Phe Asp Ala Pro Asp Asp Phe Tyr 50 55 60 Ser Asp Ala Lys Leu Val Leu Ser Asp Gly Arg Glu Val Ser Phe His 65 70 75 80 Arg Cys Val Leu Ser Ala Arg Ser Ser Phe Phe Lys Ser Ala Leu Ala 85 90 95 Ala Ala Lys Lys Glu Lys Asp Ser Asn Asn Thr Ala Ala Val Lys Leu 100 105 110 Glu Leu Lys Glu Ile Ala Lys Asp Tyr Glu Val Gly Phe Asp Ser Val 115 120 125 Val Thr Val Leu Ala Tyr Val Tyr Ser Ser Arg Val Arg Pro Pro Pro 130 135 140 Lys Gly Val Ser Glu Cys Ala Asp Glu Asn Cys cys His Val Ala Cys 145 150 155 160 Arg Pro Ala Val Asp Phe Met Leu Clu Val Leu Tyr Leu Ala Phe Ile 165 170 175 Phe Lys Ile Pro Glu Leu Ile Thr Leu Tyr Gln Arg His Leu Leu Asp 180 185 190 Val Val Asp Lys Val Val Ile Glu Asp Thr Leu Val Ile Leu Lys Leu 195 200 205 Ala Asn île Cys Gly Lys Ala Cys Met Lys Leu Leu Asp Arg Cys Lys 210 215 220 Glu Ile Ile Val Lys Ser Asn Val Asp Met Val Ser Leu Glu Lys Ser 225 230 235 240 Leu Pro Glu Glu Leu Val Lys Glu Ile Ile Asp Arg Arg Lys Glu Leu 245 250 255 Gly Leu Glu Val Pro Lys Val Lys Lys His Val Ser Asn Val His Lys 260 265 270 Ala Leu Asp Ser Asp Asp Ile Glu Leu Val Lys Leu Leu Leu Lys Glu 275 280 285 Asp His Thr Asn Leu Asp Asp Ala Cys Ala Leu His Phe Ala Val Ala 290 295 300 Tyr Cys Asn Val Lys Thr Ala Thr Asp Leu Leu Lys Leu Asp Leu Ala 305 310 315 320 Asp Val Asn His Arg Asn Pro Arg Gly Tyr Thr Val Leu His Val Ala 325 330 335 Ala Met Arg Lys Glu Pro Gln Leu Ile Leu Ser Leu Leu Glu Lys Gly 340 345 350 % Ala Ser Ala Ser Glu Ala Thr Leu Glu Gly Arg Thr Ala Leu Met Ile 355 360 365 Ala Lys Gln Ala Thr Met Ala Val Glu cys Asn Asn Ile Pro Glu Gln 370 375 380 cys Lys His Ser Leu Lys Gly Arg Leu cys Val Glu Ile Leu Glu Gln 385 390 395 400 Glu Asp Lys Arg Glu Gln Ile Pro Arg Asp Val Pro Pro Ser Phe Ala 405 410 415 Val Ala Ala Asp Glu Leu Lys Met Thr Leu Leu Asp Leu Glu Asn Arg 420 425 430 Val Ala Leu Ala Gln Arg Leu Phe Pro Thr Glu Ala Gln Ala Ala Met 435 440 445 Glu Ile Ala Glu Met Lys Gly Thr Cys Glu Phe Ile Val Thr Ser Leu 450 455 460 Glu Pro Asp Arg Leu Thr Gly Thr Lys Arg Thr Ser Pro Gly Val Lys 465 470 475 480 Ile Ala Pro Phe Arg Ile Leu Glu Glu His Gln Ser Arg Leu Lys Ala 485 490 495 Leu Ser Lys Thr Val Glu Leu Gly Lys Arg Phe Phe Pro Arg Cys Ser 500 505 510 Ala Val Leu Asp Gln Ile Met Asn Cys Glu Asp Leu Thr Gln Leu Ala 515 520 525 cys Gly Glu Asp Asp Thr Ala Glu Lys Arg Leu Gln Lys Lys Gln Arg 530 535 540 Tyr Met Glu Ile Gln Glu Thr Leu Lys Lys Ala Phe Ser Glu Asp Asn 545 550 555 560 Leu Glu Leu Gly Asn Leu Ser Leu Thr Asp Ser Thr Ser Ser Thr Ser 565 570 575 Lys Ser Thr Gly Gly Lys Arg Ser Asn Arg Lys Leu Ser His Arg Arg 580 585 590 Arg * (2) INFORMATIONS POUR LA SEQUENCE SEQ ID NO:24 (i) CARACTERISTIQUES DE LA SEQUENCE (A) LONGUEUR : 1597 paires de bases (B) TYPE : acide nucléique (C) NATURE DES BRINS : simple brin (D) TOPOLOGIE : linéaire (ii) TYPE DE MOLECULE : ADNc (ix) PARTICULARITE (A) NOM/CLE : CDS (B) LOCALISATION : 1..1410 (D) AUTRES INFORMATIONS : /produit = "Forme modifiée du NIM1" /note = "Délétion N-terminale par comparaison à la séquence du NIM1 du type sauvage" (xi) DESCRIPTION DE LA SEQUENCE SEQ ID NO:24 ATG GAT TCC GTT GTG ACT GTT TTG GCT TAT GTT TAC AGC AGC AGA GTG 48 Met Asp Ser Val Val Thr Val Leu Ala Tyr Val Tyr Ser Ser Arg Val 1 5 10 15 AGA CCG CCG CCT AAA GGA GTT TCT GAA TGC GCA GAC GAG AAT TGC TGC 96 Arg Pro Pro Pro Lys Gly Val Ser Glu Cys Ala Asp Glu Asn Cys Cys 20 25 30 CAC GTG GCT TGC CGG CCG CCC GTG GAT TTC ATG TTG GAG GTT CTC TAT 144 His Val Ala Cys Arg Pro Ala Val Asp Phe Met Leu Glu Val Leu Tyr 35 40 45 TTG GCT TTC ATC TTC AAG ATC CCT GAA TTA ATT ACT CTC TAT CAG AGG 192 Leu Ala Phe Ile Phe Lys Ile Pro Glu Leu Ile Thr Leu Tyr Gln Arg 50 55 60 CAC TTA TTG GAC GTT GTA GAC AAA GTT GTT ATA GAG GAC ACA TTG GTT 240 His Leu Leu Asp Val Val Asp Lys Val Val Ile Glu Asp Thr Leu Val 65 70 75 80 ATA CTC AAG CTT GCT AAT ATA TGT GGT AAA GCT TGT ATG AAC CTA TTG 288 Ile Leu Lys Leu Ala Asn Ile Cys Gly Lys Ala cys Met Lys Leu Leu 85 90 95 GAT AGA TGT AAA GAG ATT ATT CTC AAC TCT AAT GTA GAT ATG GTT AGT 336 Asp Arg Cys Lys Glu Ile Ile Val Lys Ser Asn Val Asp Met Val Ser 100 105 110 CTT GAA AAC TCA TTG CCG GAA GAG CTT GTT AAA GAG ATA ATT GAT AGA 384 Leu Glu Lys Ser Leu Pro Glu Glu Leu Val Lys Glu Ile Ile Asp Arg 115 120 125 CGT AAA GAG CTT GGT TTG GAG GTA CCT AAA GTA AAC AAA CAT GTC TCG 432 Arg Lys Glu Leu Gly Leu Glu Val Pro Lys Val Lys Lys His Val Ser 130 135 140 AAT GTA CAT AAC GCA CTT GAC TCG GAT GAT ATT GAG TTA GTC AAC TTG 480 Asn Val His Lys Ala Leu Asp Ser Asp Asp Ile Glu Leu Val Lys Leu 145 150 155 160 CTT TTG AAA GAG GAT CAC ACC AAT CTA GAT GAT CCC TGT GCT CTT CAT 528 Leu Leu Lys Glu Asp His Thr Asn Leu Asp Asp Ala Cys Ala Leu His 165 170 175 TTC GCT GTT GCA TAT TGC AAT GTC AAG ACC GCA ACA GAT CTT TTA AAA 576 Phe Ala Val Ala Tyr Cys Asn Val Lys Thr Ala Thr Asp Leu Leu Lys 180 185 190 CTT GAT CTT GCC GAT CTC AAC CAT AGG AAT CCG AGG GGA TAT ACG GTG 624 Leu Asp Leu Ala Asp Val Asn His Arg Asn Pro Arg Gly Tyr Thr Val 195 200 205 CTT CAT GTT GCT CCC ATG CGG AAC GAG CCA CAA TTG ATA CTA TCT CTA 672 Leu His Val Ala Ala Met Arg Lys Glu Pro Gln Leu Ile Leu Ser Leu 210 215 220 TTG GAA AAA CGT GCA AGT GCA TCA GAA GCA ACT TTC GAA GCT AGA ACC 720 Leu Glu Lys Gly Ala Ser Ala Ser Glu Ala Thr Leu Glu Gly Arg Thr 225 230 235 240 GCA CTC ATG ATC GCA AAA CAA GCC ACT ATG CCC GTT GAA TGT AAT AAT 768 Ala Leu Met Ile Ala Lys Gln Ala Thr Met Ala Val Glu Cys Asn Asn 245 250 255 ATC CCG GAG CAA TGC AAC CAT TCT CTC AAA CCC CGA CTA TGT GTA GAA 816 Ile Pro Glu Gln Cys Lys His Ser Leu Lys Gly Arg Leu Cys Val Glu 260 265 270 ATA CTA GAG CAA GAA GAC AAA CGA GAA CAA ATT CCT AGA GAT GTT CCT 864 Ile Leu Glu Gln Glu Asp Lys Arg Glu Gln Ile Pro Arg Asp Val Pro 275 280 285 CCC TCT TTT GCA GTG GCG GCC GAT GAA TTC AAC ATG ACG CTG CTC GAT 912 Pro Ser Phe Ala Val Ala Ala Asp Glu Leu Lys Met Thr Leu Leu Asp 290 295 300 CTT GAA AAT AGA GTT GCA CTT CCT CAA CGT CTT TTT CCA ACG GAA GCA 960 Leu Glu Asn Arg Val Ala Leu Ala Gln Arg Leu Phe Pro Thr Glu Ala 305 310 315 320 CAA GCT GCA ATG GAG ATC GCC GAA ATG AAC GGA ACA TGT GAG TTC ATA 1008 Gin Ala Ala Met Glu Ile Ala Glu Met Lys Gly Thr cys Glu Phe Ile 325 330 335 GTG ACT AGC CTC GAG CCT GAC CGT CTC ACT GGT ACG AAG AGA ACA TCA 1056 Val Thr Ser Leu Glu Pro Asp Arg Leu Thr Gly Thr Lys Arg Thr Ser 340 345 350 CCG GGT GTA AAC ATA GCA CCT TTC AGA ATC CTA GAA GAG CAT CAA AGT 1104 Pro Gly Val Lys Ile Ala Pro Phe Arg Ile Leu Glu Glu His Gln Ser 355 360 365 AGA CTA AAA GCG CTT TCT AAA ACC GTG GAA CTC GGG AAA CGA TTC TTC 1152 Arg Leu Lys Ala Leu Ser Lys Thr Val Glu Leu Gly Lys Arg Phe Phe 370 375 380 CCG CCC TGT TCC GCA GTG CTC GAC CAG ATT ATG AAC TGT GAG GAC TTG 1200 Pro Arg Cys Ser Ala Val Leu Asp Gln Ile Met Asn Cys Glu Asp Leu 385 390 395 400 ACT CAA CTG GCT TGC GGA GAA GAC GAC ACT GCT GAG AAA CGA CTA CAA 1248 Thr Gln Leu Ala Cys Gly Glu Asp Asp Thr Ala Glu Lys Arg Leu Gln 405 410 415 AAC AAC CAA AGG TAC ATC GAA ATA CAA GAG ACA CTA AAG AAG CCC TTT 1296 Lys Lys Gln Arg Tyr Met Glu Ile Gln Glu Thr Leu Lys Lys Ala Phe 420 425 430 AGT GAG GAC AAT TTG GAA TTA GGA AAT TTG TCC CTC ACA GAT TCG ACT 1344 Ser Glu Asp Asn Leu Glu Leu Gly Asn Leu Ser Leu Thr Asp Ser Thr 435 440 445 TCT TCC ACA TCC AAA TCA ACC GGT GGA AAG AGG TCT AAC CGT AAA CTC 1392 Ser Ser Thr Ser Lys Ser Thr Gly Gly Lys Arg Ser Asn Arg Lys Leu 450 455 460 TCT CAT CGT CGT CGC TCA GACTCTTGCC TCTTAGTGTA ATTTTTGCTG 1440 Ser His Arg Arg Arg * 465 470 TACCATATAA TTCTGTTTTC ATGATGACTG TAACTGTTTA TGTCTATCGT TGGCGTCATA 1500 TAGTTTCGCT CTTCGTTTTG CATCCTGTGT ATTATTGCTG CAGGTGTGCT TCAAACAAAT 1560 GTTGTAACAA TTTGAACCAA TGGTATACAG ATTTCTA 1597 (2) INFORMATIONS POUR LA SEQUENCE SEQ ID NO:25 (i) CARACTERISTIQUES DE LA SEQUENCE (A) LONGUEUR : 470 acides aminés (B) TYPE : acide aminé (D) TOPOLOGIE : linéaire (ii) TYPE DE MOLECULE : protéine (xi) DESCRIPTION DE LA SEQUENCE SEQ ID NO:25 Met Asp Ser Val Val Thr Val Leu Ala Tyr Val Tyr Ser Ser Arg Val 1 5 10 15 Arg Pro Pro Pro Lys Gly Val Ser Glu cys Ala Asp Glu Asn cys cys 20 25 30 His Val Ala cys Arg Pro Ala Val Asp Phe Met Leu Glu Val Leu Tyr 35 40 45 Leu Ala Phe Ile Phe Lys Ile Pro Glu Leu Ile Thr Leu Tyr Gln Arg 50 55 60 His Leu Leu Asp Val Val Asp Lys Val Val Ile Glu Asp Thr Leu Val 65 70 75 80 Ile Leu Lys Leu Ala Asn Ile cys Gly Lys Ala Cys Met Lys Leu Leu 85 90 95 Asp Arg Cys Lys Glu Ile Ile Val Lys Ser Asn Val Asp Met Val Ser 100 105 110 Leu Glu Lys Ser Leu Pro Glu Glu Leu Val Lys Glu Ile Ile Asp Arg 115 120 125 Arg Lys Glu Leu Gly Leu Glu Val Pro Lys Val Lys Lys His Val Ser 130 135 140 Asn Val His Lys Ala Leu Asp Ser Asp Asp Ile Glu Leu Val Lys Leu 145 150 155 160 Leu Leu Lys Glu Asp His Thr Asn Leu Asp Asp Ala Cys Ala Leu His 165 170 175 Phe Ala Val Ala Tyr Cys Asn Val Lys Thr Ala Thr Asp Leu Leu Lys 180 185 190 Leu Asp Leu Ala Asp Val Asn His Arg Asn Pro Arg Gly Tyr Thr Val 195 200 205 Leu His Val Ala Ala Met Arg Lys Glu Pro Gln Leu Ile Leu Ser Leu 210 215 220 Leu Glu Lys Gly Ala Ser Ala Ser Glu Ala Thr Leu Glu Gly Arg Thr 225 230 235 240 Ala Leu Met Ile Ala Lys Gln Ala Thr Met Ala Val Glu Cys Asn Asn 245 250 255 Ile Pro Glu Gln cys Lys His Ser Leu Lys Gly Arg Leu cys Val Glu 260 265 270 Ile Leu Glu Gln Glu Asp Lys Arg Glu Gln Ile Pro Arg Asp Val Pro 275 280 285 Pro Ser Phe Ala Val Ala Ala Thr Gln Leu u Ala cys Gly Glu Asp Asp Thr Ala Glu Lys Arg Leu Gin 405 410 415 Lys Lys Gln Arg Tyr Met Glu Ile Gln Glu Thr Leu Lys Lys Ala Phe 420 425 430 Ser Glu Asp Asn Leu Glu Leu Gly Asn Leu Ser Leu Thr Asp Ser Thr 435 440 445 Ser Ser Thr Ser Lys Ser Thr Gly Gly Lys Arg Ser Asn Arg Lys Leu 450 455 460 Ser His Arg Arg Arg 465 470 (2) INFORMATIONS POUR LA SEQUENCE SEQ ID NO:26 : (i) CARACTERISTIQUES DE LA SEQUENCE (A) LONGUEUR : 1608 paires de bases (B) TYPE : acide nucléique (C) NATURE DES BRINS : simple brin (D) TOPOLOGIE : linéaire (ii) TYPE DE MOLECULE : ADNc (ix) PARTICULARITE: (A) NOM/CLE : CDS (B) LOCALISATION : 43..1608 (D) AUTRES INFORMATIONS : /produit = = "forme modifiée du u NIM1" /note = = "Délétion C-terminale par rapport au u NIM1 de type sauvage" (xi) DESCRIPTION DE LA SEQUENCE SEQ ID NO:26 GATCTCTTTA ATTTGTGAAT TTCAATTCAT CGGAACCTGT TG ATC GAC ACC ACC 54 Met Asp Thr Thr 1 ATT GAT GGA TTC GCC GAT TCT TAT GAA ATC AGC AGC ACT AGT TTC GTC 102 Ile Asp Gly Phe Ala Asp Ser Tyr Glu Ile Ser Ser Thr Ser Phe Val 5 10 15 20 GCT ACC GAT AAC ACC GAC TCC TCT ATT GTT TAT CTC GCC GCC GAA CAA 150 Ala Thr Asp Asn Thr Asp Ser Ser Ile Val Tyr Leu Ala Ala Glu Gln 25 30 35 GTA CTC ACC GGA CCT GAT GTA TCT GCT CTG CAA TTG CTC TCC AAC AGC 198 Val Leu Thr Gly Pro Asp Val Ser Ala Leu Gln Leu Leu Ser Asn Ser 40 45 50 TTC GAA TCC GTC TTT GAC TCG CCG GAT GAT TTC TAC AGC GAC GCT AAC 246 Phe Glu Ser Val Phe Asp Ser Pro Asp Asp Phe Tyr Ser Asp Ala Lys 55 60 65 CTT GTT CTC TCC GAC GGC CGC GAA GTT TCT TTC CAC CGC TGC GTT TTC 294 Leu Val Leu Ser Asp Gly Arg Glu Val Ser Phe His Arg Cys Val Leu 70 75 80 TCA CCC AGA AGC TCT TTC TTC AAG AGC GCT TTA GCC GCC GCT AAG AAC 342 Ser Ala Arg Ser Ser Phe Phe Lys Ser Ala Leu Ala Ala Ala Lys Lys 85 90 95 100 GAG AAA GAC TCC AAC AAC ACC GCC CCC GTG AAG CTC GAG CTT AAC GAG 390 Glu Lys Asp Ser Asn Asn Thr Ala Ala Val Lys Leu Glu Leu Lys Glu 105 110 115 ATT GCC AAC CAT TAC GAA GTC GGT TTC GAT TCG GTT GTG ACT GTT TTC 438 Ile Ala Lys Asp Tyr Glu Val Gly Phe Asp Ser Val Val Thr Val Leu 120 125 130 GCT TAT GTT TAC AGC AGC AGA CTG AGA CCG CCG CCT AAA GCA GTT TCT 486 Ala Tyr Val Tyr Ser Ser Arg Val Arg Pro Pro Pro Lys Gly Val Ser 135 140 145 GAA TGC GCA GAC GAG AAT TGC TGC CAC GTG GCT TGC CGC CCG CCC GTG 534 Glu Cys Ala Asp Glu Asn Cys Cys His Val Ala Cys Arg Pro Ala Val 150 155 160 GAT TTC ATG TTG GAG GTT CTC TAT TTG GCT TTC ATC TTC AAG ATC CCT 582 Asp Phe Met Leu Glu Val Leu Tyr Leu Ala Phe Ile Phe Lys Ile Pro 165 170 175 180 GAA TTA ATT ACT CTC TAT CAG AGG CAC TTA TTC GAC GTT GTA GAC AAA 630 Glu Leu Ile Thr Leu Tyr Gln Arg His Leu Leu Asp Val Val Asp Lys 185 190 195 GTT GTT ATA GAG GAC ACA TTC GTT ATA CTC AAG CTT GCT AAT ATA TGT 678 Val Val Ile Clu Asp Thr Leu Val Ile Leu Lys Leu Ala Asn Ile Cys 200 205 210 GGT AAA GCT TGT ATG AAC CTA TTG GAT AGA TGT AAA GAG ATT ATT GTC 726 Gly Lys Ala Cys Met Lys Leu Leu Asp Arg Cys Lys Glu Ile Ile Val 215 220 225 AAC TCT AAT GTA GAT ATG GTT AGT CTT GAA AAG TCA TTG CCG GAA GAG 774 Lys Ser Asn Val Asp Met Val Ser Leu Glu Lys Ser Leu Pro Glu Glu 230 235 240 CTT GTT AAA GAG ATA ATT GAT AGA CGT AAA GAG CTT GGT TTG GAG GTA 822 Leu Val Lys Glu Ile Ile Asp Arg Arg Lys Glu Leu Gly Leu Glu Val 245 250 255 260 CCT AAA GTA AAG AAA CAT GTC TCC AAT GTA CAT AAC GCA CTT GAC TCC 870 Pro Lys Val Lys Lys His Val Ser Asn Val His Lys Ala Leu Asp Ser 265 270 275 GAT GAT ATT GAG TTA GTC AAC TTG CTT TTG AAA GAG GAT CAC ACC AAT 918 Asp Asp Ile Glu Leu Val Lys Leu Leu Leu Lys Glu Asp His Thr Asn 280 285 290 CTA GAT GAT GCG TGT GCT CTT CAT TTC GCT GTT GCA TAT TGC AAT GTG 966 Leu Asp Asp Ala cys Ala Leu His Phe Ala Val Ala Tyr cys Asn Val 295 300 305 AAC ACC GCA ACA GAT CTT TTA AAA CTT GAT CTT GCC GAT GTC AAC CAT 1014 Lys Thr Ala Thr Asp Leu Leu Lys Leu Asp Leu Ala Asp Val Asn His 310 315 320 AGG AAT CCG AGG GGA TAT ACG GTG CTT CAT GTT GCT CCC ATG CGG AAC 1062 Arg Asn Pro Arg Gly Tyr Thr Val Leu His Val Ala Ala Met Arg Lys 325 330 335 340 GAG CCA CAA TTG ATA CTA TCT CTA TTG GAA AAA GGT GCA AGT GCA TCA 1110 Glu Pro Gln Leu Ile Leu Ser Leu Leu Glu Lys Gly Ala Ser Ala Ser 345 350 355 GAA GCA ACT TTG GAA GGT AGA ACC GCA CTC ATG ATC GCA AAA CAA GCC 1158 Glu Ala Thr Leu Glu Gly Arg Thr Ala Leu Met Ile Ala Lys Gln Ala 360 365 370 ACT ATG CCC GTT GAA TGT AAT AAT ATC CCG GAG CAA TGC AAC CAT TCT 1206 Thr Met Ala Val Glu Cys Asn Asn Ile Pro Glu Gln Cys Lys His Ser 375 380 385 CTC AAA GGC CGA CTA TGT GTA GAA ATA CTA GAG CAA GAA GAC AAA CGA 1254 Leu Lys C1y Arg Leu Cys Val Glu Ile Leu Glu Gln Glu Asp Lys Arg 390 395 400 GAA CAA ATT CCT AGA GAT GTT CCT CCC TCT TTT GCA GTG CCC GCC GAT 1302 Glu Gln Ile Pro Arg Asp Val Pro Pro Ser Phe Ala Val Ala Ala Asp 405 410 415 420 GAA TTG AAG ATG ACG CTG CTC GAT CTT GAA AAT AGA GTT GCA CTT GCT 1350 Glu Leu Lys Met Thr Leu Leu Asp Leu Glu Asn Arg Val Ala Leu Ala 425 430 435 CAA CCT CTT TTT CCA ACG GAA GCA CAA GCT GCA ATC GAG ATC GCC CAA 1398 Gln Arg Leu Phe Pro Thr Glu Ala Gln Ala Ala Met Glu Ile Ala Glu 440 445 450 ATC AAC GGA ACA TGT GAG TTC ATA GTG ACT AGC CTC GAG CCT GAC CGT 1446 Met Lys Gly Thr Cys Glu Phe Ile Val Thr Ser Leu Glu Pro Asp Arg 455 460 465 CTC ACT GGT ACG AAC AGA ACA TCA CCG GGT GTA AAC ATA CCA CCT TTC 1494 Leu Thr Gly Thr Lys Arg Thr Ser Pro Gly Val Lys Ile Ala Pro Phe 470 475 480 AGA ATC CTA GAA GAG CAT CAA AGT AGA CTA AAA CCC CTT TCT AAA ACC 1542 Arg Ile Leu Glu Glu His Gln Ser Arg Leu Lys Ala Leu Ser Lys Thr 485 490 495 500 GTG GAA CTC GGG AAA CCA TTC TTC CCG CGC TGT TCC GCA GTG CTC GAC 1590 Val Glu Leu Gly Lys Arg Phe Phe Pro Arg Cys Ser Ala Val Leu Asp 505 510 515 CAG ATT ATG AAC TGT TCA 1608 Gln Ile Met Asn Cys * 520 (2) INFORMATIONS POUR LA SEQUENCE SEQ ID NO:27 (i) CARACTERISTIQUES DE LA SEQUENCE (A) LONGUEUR : 522 acides aminés (B) TYPE : acide nucléique (D) TOPOLOGIE : linéaire (ii) TYPE DE MOLECULE : protéine (xi) DESCRIPTION DE LA SEQUENCE SEQ ID NO:27 Met Asp Thr Thr Ile Asp Gly Phe Ala Asp Ser Tyr Glu Ile Ser Ser 1 5 10 15 Thr Ser Phe Val Ala Thr Asp Asn Thr Asp Ser Ser Ile Val Tyr Leu 20 25 30 Ala Ala Glu Gln Val Leu Thr Gly Pro Asp Val Ser Ala Leu Gln Leu 35 40 45 Leu Ser Asn Ser Phe Glu Ser Val Phe Asp Ser Pro Asp Asp Phe Tyr 50 55 60 Ser Asp Ala Lys Leu Val Leu Ser Asp Gly Arg Glu Val Ser Phe His 65 70 75 80 Arg Cys Val Leu Ser Ala Arg Ser Ser Phe Phe Lys Ser Ala Leu Ala 85 90 95 Ala Ala Lys Lys Glu Lys Asp Ser Asn Asn Thr Ala Ala Val Lys Leu 100 105 110 Glu Leu Lys Glu Ile Ala Lys Asp Tyr Glu Val Gly Phe Asp Ser Val 115 120 125 Val Thr Val Leu Ala Tyr Val Tyr Ser Ser Arg Val Arg Pro Pro Pro 130 135 140 Lys Gly Val Ser Glu Cys Ala Asp Glu Asn Cys cys His Val Ala Cys 145 150 155 160 Arg Pro Ala Val Asp Phe Met Leu Glu Val Leu Tyr Leu Ala Phe Ile 165 170 175 Phe Lys île Pro Glu Leu Ile Thr Leu Tyr Gln Arg His Leu Leu Asp 180 185 190 Val Val Asp Lys Val Val Ile Glu Asp Thr Leu Val Ile Leu Lys Leu 195 200 205 Ala Asn Ile Cys Gly Lys Ala cys Met Lys Leu Leu Asp Arg Cys Lys 210 215 220 Glu Ile Ile Val Lys Ser Asn Val Asp Met Val Ser Leu Glu Lys Ser 225 230 235 240 Leu Pro Glu Glu Leu Val Lys Glu Ile Ile Asp Arg Arg Lys Glu Leu 245 250 255 Cly Leu Glu Val Pro Lys Val Lys Lys His Val Ser Asn Val His Lys 260 265 270 Ala Leu Asp Ser Asp Asp Ile Glu Leu Val Lys Leu Leu Leu Lys Glu 275 280 285 Asp His Thr Asn Leu Asp Asp Ala Cys Ala Leu His Phe Ala Val Ala 290 295 300 Tyr Cys Asn Val Lys Thr Ala Thr Asp Leu Leu Lys Leu Asp Leu Ala 305 310 315 320 Asp Val Asn His Arg Asn Pro Arg Gly Tyr Thr Val Leu His Val Ala 325 330 335 Ala Met Arg Lys Glu Pro Gln Leu Ile Leu Ser Leu Leu Glu Lys Gly 340 345 350 Ala Ser Ala Ser Glu Ala Thr Leu Glu Gly Arg Thr Ala Leu Met Ile 355 360 365 Ala Lys Gln Ala Thr Met Ala Val Glu Cys Asn Asn Ile Pro Glu Gln 370 375 380 Cys Lys His Ser Leu Lys Gly Arg Leu Cys Val Glu Ile Leu Glu Gln 385 390 395 400 Glu Asp Lys Arg Glu Gln Ile Pro Arg Asp Val Pro Pro Ser Phe Ala 405 410 415 Val Ala Ala Asp Glu Leu Lys Met Thr Leu Leu Asp Leu Glu Asn Arg 420 425 430 Val Ala Leu Ala Gln Arg Leu Phe Pro Thr Glu Ala Gln Ala Ala Met 435 440 445 Clu Ile Ala Glu Met Lys Gly Thr Cys Glu Phe Ile Val Thr Ser Leu 450 455 460 Glu Pro Asp Arg Leu Thr Gly Thr Lys Arg Thr Ser Pro Gly Val Lys 465 470 475 480 Ile Ala Pro Phe Arg Ile Leu Glu Glu His Gln Ser Arg Leu Lys Ala 485 490 495 Leu Ser Lys Thr Val Glu Leu Gly Lys Arg Phe Phe Pro Arg Cys Ser 500 505 510 Ala Val Leu Asp Gln Ile Met Asn Cys * 515 520 (2) INFORMATIONS POUR LA SEQUENCE SEQ ID NO:28 (i) CARACTERISTIQUES DE LA SEQUENCE (A) LONGUEUR : 1194 paires de bases (B) TYPE : acide nucléique (C) NATURE DES BRINS : simple brin (D) TOPOLOGIE : linéaire (ii) TYPE DE MOLECULE : ADNc (ix) PARTICULARITE (A) NOM/CLE : CDS (B) LOCALISATION : 1..1194 (D) AUTRES INFORMATIONS : /produit = "forme modifiée du NIM1" /note = "Chimère N-terminale/C-terminale" (xi) DESCRIPTION DE LA SEQUENCE SEQ ID NO:28 ATG GAT TCC GTT GTG ACT GTT TTG GCT TAT GTT TAC AGC AGC AGA GTG 48 Met Asp Ser Val Val Thr Val Leu Ala Tyr Val Tyr Ser Ser Arg Val 1 5 10 15 AGA CCC CCG CCT AAA GGA GTT TCT GAA TGC GCA GAC GAG AAT TGC TGC 96 Arg Pro Pro Pro Lys Gly Val Ser Glu Cys Ala Asp Glu Asn Cys Cys 20 25 30 CAC CTC GCT TGC CGG CCG CCC GTG GAT TTC ATG TTG GAG GTT CTC TAT 144 His Val Ala Cys Arg Pro Ala Val Asp Phe Met Leu Glu Val Leu Tyr 35 40 45 TTG GCT TTC ATC TTC AAG ATC CCT GAA TTA ATT ACT CTC TAT CAG AGG 192 Leu Ala Phe Ile Phe Lys Ile Pro Glu Leu Ile Thr Leu Tyr Gln Arg 50 55 60 CAC TTA TTG GAC GTT GTA GAC AAA GTT GTT ATA GAG GAC ACA TTG GTT 240 His Leu Leu Asp Val Val Asp Lys Val Val Ile Glu Asp Thr Leu Val 65 70 75 80 ATA CTC AAC CTT GCT AAT ATA TGT GGT AAA GCT TGT ATG AAC CTA TTG 288 Ile Leu Lys Leu Ala Asn Ile Cys Gly Lys Ala Cys Met Lys Leu Leu 85 90 95 GAT AGA TGT AAA GAG ATT ATT GTC AAC TCT AAT GTA GAT ATG GTT AGT 336 Asp Arg Cys Lys Glu Ile Ile Val Lys Ser Asn Val Asp Met Val Ser 100 105 110 CTT GAA AAC TCA TTG CCG GAA GAG CTT GTT AAA GAG ATA ATT GAT AGA 384 Leu Glu Lys Ser Leu Pro Glu Glu Leu Val Lys Glu Ile Ile Asp Arg 115 120 125 CGT AAA GAG CTT GGT TTG GAG GTA CCT AAA GTA AAG AAA CAT GTC TCG 432 Arg Lys Glu Leu Gly Leu Glu Val Pro Lys Val Lys Lys His Val Ser 130 135 140 AAT GTA CAT AAC GCA CTT GAC TCC GAT GAT ATT GAG TTA GTC AAC TTG 480 Asn Val His Lys Ala Leu Asp Ser Asp Asp Ile Glu Leu Val Lys Leu 145 150 155 160 CTT TTG AAA GAG GAT CAC ACC AAT CTA GAT GAT CCC TGT GCT CTT CAT 528 Leu Leu Lys Glu Asp His Thr Asn Leu Asp Asp Ala Cys Ala Leu His 165 170 175 TTC GCT GTT GCA TAT TOC AAT GTG AAG ACC GCA ACA GAT CTT TTA AAA 576 Phe Ala Val Ala Tyr Cys Asn Val Lys Thr Ala Thr Asp Leu Leu Lys 180 185 190 CTT GAT CTT GCC GAT GTC AAC CAT AGG AAT CCG AGG GCA TAT ACG GTG 624 Leu Asp Leu Ala Asp Val Asn His Arg Asn Pro Arg Gly Tyr Thr Val 195 200 205 CTT CAT GTT GCT CCC ATG CGC AAG GAG CCA CAA TTG ATA CTA TCT CTA 672 Leu His Val Ala Ala Met Arg Lys Glu Pro Gln Leu Ile Leu Ser Leu 210 215 220 TTG GAA AAA GGT GCA AGT GCA TCA GAA GCA ACT TTG GAA GGT AGA ACC 720 Leu Glu Lys Gly Ala Ser Ala Ser Glu Ala Thr Leu Glu Gly Arg Thr 225 230 235 240 GCA CTC ATG ATC GCA AAA CAA GCC ACT ATG CCC GTT GAA TGT AAT AAT 768 Ala Leu Met Ile Ala Lys Gln Ala Thr Met Ala Val Glu cys Asn Asn 245 250 255 ATC CCG GAG CAA TGC AAC CAT TCT CTC AAA GGC CGA CTA TGT GTA GAA 816 Ile Pro Glu Gln Cys Lys His Ser Leu Lys Gly Arg Leu Cys Val Glu 260 265 270 ATA CTA GAG CAA GAA GAC AAA CGA GAA CAA ATT CCT AGA GAT GTT CCT 864 Ile Leu Glu Gln Glu Asp Lys Arg Glu Gln Ile Pro Arg Asp Val Pro 275 280 285 CCC TCT TTT GCA GTG CCC GCC GAT GAA TTG AAC ATG ACG CTC CTC GAT 912 Pro Ser Phe Ala Val Ala Ala Asp Glu Leu Lys Met Thr Leu Leu Asp 290 295 300 CTT GAA AAT AGA GTT GCA CTT GCT CAA CGT CTT TTT CCA ACG GAA GCA 960 Leu Glu Asn Arg Val Ala Leu Ala Gln Arg Leu Phe Pro Thr Glu Ala 305 310 315 320 CAA GCT GCA ATG GAG ATC CCC GAA ATG AAG GGA ACA TGT GAG TTC ATA 1008 Gln Ala Ala Met Glu Ile Ala Glu Met Lys Gly Thr Cys Glu Phe Ile 325 330 335 GTG ACT AGC CTC GAG CCT GAC CGT CTC ACT GGT ACG AAC AGA ACA TCA 1056 Val Thr Ser Leu Glu Pro Asp Arg Leu Thr Gly Thr Lys Arg Thr Ser 340 345 350 CCG GGT GTA AAC ATA GCA CCT TTC AGA ATC CTA GAA GAG CAT CAA AGT 1104 Pro Gly Val Lys Ile Ala Pro Phe Arg Ile Leu Glu Glu His Gln Ser 355 360 365 AGA CTA AAA GCG CTT TCT AAA ACC GTG GAA CTC GGG AAA CGA TTC TTC .1152 Arg Leu Lys Ala Leu Ser Lys Thr Val Glu Leu Gly Lys Arg Phe Phe 370 375 380 CCG CCC TGT TCC GCA GTG CTC GAC CAG ATT ATG AAC TGT TGA 1194 Pro Arg Cys Ser Ala Val Leu Asp Gln Ile Met Asn Cys * 385 390 395 (2) INFORMATIONS POUR LA SEQUENCE SEQ ID NO:29 (i) CARACTERISTIQUES DE LA SEQUENCE (A) LONGUEUR : 398 acides aminés (B) TYPE : acide aminé (D) TOPOLOGIE : linéaire (ii) TYPE DE MOLECULE : protéine (xi) DESCRIPTION DE LA SEQUENCE SEQ ID NO:29 Met Asp Ser Val Val Thr Val Leu Ala Tyr Val Tyr Ser Ser Arg Val 1 5 10 15 Arg Pro Pro Pro Lys Gly Val Ser Glu cys Ala Asp Glu Asn Cys Cys 20 25 30 His Val Ala Cys Arg Pro Ala Val Asp Phe Met Leu Glu Val Leu Tyr 35 40 45 Leu Ala Phe Ile Phe Lys Ile Pro Glu Leu Ile Thr Leu Tyr Gln Arg 50 55 60 His Leu Leu Asp Val Val Asp Lys Val Val Ile Glu Asp Thr Leu Val 65 70 75 80 Ile Leu Lys Leu Ala Asn Ile Cys Gly Lys Ala Cys Met Lys Leu Leu 85 90 95 Asp Arg Cys Lys Glu Ile Ile Val Lys Ser Asn Val Asp Met Val Ser 100 105 110 Leu Glu Lys Ser Leu Pro Glu Glu Leu Val Lys Glu Ile Ile Asp Arg 115 120 125 Arg Lys Glu Leu Gly Leu Glu Val Pro Lys Val Lys Lys His Val Ser 130 135 140 Asn Val His Lys Ala Leu Asp Ser Asp Asp Ile Glu Leu Val Lys Leu 145 150 155 160 Leu Leu Lys Glu Asp His Thr Asn Leu Asp Asp Ala Cys Ala Leu His 165 170 175 Phe Ala Val Ala Tyr Cys Asn Val Lys Thr Ala Thr Asp Leu Leu Lys 180 185 190 Leu Asp Leu Ala Asp Val Asn His Arg Asn Pro Arg Gly Tyr Thr Val 195 200 205 Leu His Val Ala Ala Met Arg Lys Glu Pro Gln Leu Ile Leu Ser Leu 210 215 220 Leu Glu Lys Gly Ala Ser Ala Ser Glu Ala Thr Leu Glu Gly Arg Thr 225 230 235 240 Ala Leu Met Ile Ala Lys Gln Ala Thr Met Ala Val Glu Cys Asn Asn 245 250 255 île Pro Glu Gln Cys Lys His Ser Leu Lys Gly Arg Leu Cys Val Glu 260 265 270 Ile Leu Glu Gln Glu Asp Lys Arg Glu Gln Ile Pro Arg Asp Val Pro 275 280 285 Pro Ser Phe Ala Val Ala Ala Asp Glu Leu Lys Met Thr Leu Leu Asp 290 295 300 Leu Glu Asn Arg Val Ala Leu Ala Gln Arg Leu Phe Pro Thr Glu Ala 305 310 315 320 Gln Ala Ala Met Glu Ile Ala Glu Met Lys Gly Thr Cys Glu Phe Ile 325 330 335 Val Thr Ser Leu Glu Pro Asp Arg Leu Thr Gly Thr Lys Arg Thr Ser 340 345 350 Pro Gly Val Lys Ile Ala Pro Phe Arg Ile Leu Glu Glu His Gln Ser 355 360 365 Arg Leu Lys Ala Leu Ser Lys Thr Val Glu Leu Gly Lys Arg Phe Phe 370 375 380 Pro Arg cys Ser Ala Val Leu Asp Gln Ile Met Asn Cys * 385 390 395 (2) INFORMATIONS POUR LA SEQUENCE SEQ ID NO:30 (i) CARACTERISTIQUES DE LA SEQUENCE (A) LONGUEUR : 786 paires de bases (B) TYPE : acide nucléique (C) NATURE DES BRINS : simple brin (D) TOPOLOGIE : linéaire (ii) TYPE DE MOLECULE : ADNc (ix) PARTICULARITE (A) NOM/CLE : CDS (B) LOCALISATION : 1..786 (D) AUTRES INFORMATIONS : produit = "forme modifiée du NIM1" /note = "Domaines ankyrine du NIM1".