LISTE DE SEQUENCES NOMBRE DE SEQUENCES: 8 1 > lirOinTici POICIR aQ ID Mo: 1: (i) CARACTERISTIQUES DE LA SEQUENCE: (A) LONGUEUR: 312 paires de bases (B) TYPE: acide nucléique (C) NOMBRE DE BRINS: double (D) CONFIGURATION: linéaire (ix) CARACTERISTIQUE ADDITIONELLE: (A) NOM/CLE: CDS (B) EMPLACEMENT: 1..312 (D) AUTRES RENSEIGNEMENTS: /produit= Region variable d'Immunoglobuline (ix) CARACTERISTIQUE ADDITIONELLE: (A) NOM/CLE: (B) EMPLACEMENT: 67..99 (D) AUTRES RENSEIGNEMENTS: /label= CDR1 (ix) CARACTERISTIQUE ADDITIONELLE: (A) NOM/CLE: (B) EMPLACEMENT: 145..165 (D) AUTRES RENSEIGNEMENTS: /label= CDR2 (ix) CARACTERISTIQUE ADDITIONELLE: (A) NOM/CLE: (B) EMPLACEMENT: 262..279 (D) AUTRES RENSEIGNEMENTS: /label= CDR3 (xi) DESCRIPTION DE LA SEQUENCE:SEQ ID NO: 1: GAC ATC GAG CTC ACT CAG GAC CCT GCT GTG TCT GTG GCC TTG GGA CAG 48 Asp Ile Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 1 5 10 15 ACA GTC AGG ATC ACA TGC CAA GGA GAC AGC CTC AGA ACC TAT TAT GCA 96 Thr Val Arg Ile Thr cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30 AGC TGG TAC CAG CAG AAG CCA GGA CAG GCA CCT GTA CTT GTC ATC TAT 144 Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 GGT AAA AAC AAC CGG CCC TCA GGG ATC CCA GAC CGA TTC TCT GGC TCC 192 Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60 AGC TCA GGA AAC ACA GCT TCC TTG ACC ATC ACT GGG GCT CAG GCG GAA 240 Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 65 70 75 80 GAT GAG GCT GAC TAT TTC TGT AAC AGC GGT GGG AAG GTG TTC GGC GGA 288 Asp Glu Ala Asp Tyr Phe Cys Asn Ser Gly Gly Lys Val Phe Gly Gly 85 90 95 GGG ACC AAG CTG ACC GTC CTA GGT 312 Gly Thr Lys Leu Thr Val Leu Gly 100 2) ISiORYATION POUR ZA gZQ ID Mo: 2: (i) CARACTERISTIQUES DE LA SEQUENCE: (A) LONGUEUR: 104 acides aminés (B) TYPE: acide aminé (D) CONFIGURATION: linéaire (xi) DESCRIPTION DE LA SEQUENCE:SEQ ID NO: 2: Asp Ile Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln 1 5 10 15 Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr Tyr Tyr Ala 20 25 30 Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 35 40 45 Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 50 55 60 Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu 65 70 75 80 Asp Glu Ala Asp Tyr Phe Cys Asn Ser Gly Gly Lys Val Phe Gly Gly 85 90 95 Gly Thr Lys Leu Thr Val Leu Gly 100 3) INFORMATION POUR LA 9EQ ID NO: 3: (i) CARACTERISTIQUES DE LA SEQUENCE: (A) LONGUEUR: 369 paires de bases (B) TYPE: acide nucléique (C) NOMBRE DE BRINS: double (D) CONFIGURATION: linéaire (ix) CARACTERISTIQUE ADDITIONELLE: (A) NOM/CLE: CDS (B) EMPLACEMENT: 1..369 (D) AUTRES RENSEIGNEMENTS: /produit= Region variable d'immunoglobuline (ix) CARACTERISTIQUE ADDITIONELLE: (A) NOM/CLE: (B) EMPLACEMENT: 91..105 (D) AUTRES RENSEIGNEMENTS: /label= CDR1 (ix) CARACTERISTIQUE ADDITIONELLE: (A) NOM/CLE: (B) EMPLACEMENT: 148..195 (D) AUTRES RENSEIGNEMENTS: /label= CDR2 (ix) CARACTERISTIQUE ADDITIONELLE: (A) NOM/CLE: (B) EMPLACEMENT: 292..336 (D) AUTRES RENSEIGNEMENTS: /label= CDR3 (xi) DESCRIPTION DE LA SEQUENCE:SEQ ID NO: 3: CAG GTC CAA CTG CAG CAG TGG GGC GCA GGA CTG TTG AAG CCT TCG GAG 48 Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 ACC CTG TCC CTC ACC TGC ACT GTC TAT GGT GGG TCC TTC AGT GGT TAC 96 Thr Leu Ser Leu Thr cys Thr Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 TAC TGG AGC TGG ATC CGC CAG CCC CCA GGG AAG GGG CTG GAG TGG ATT 144 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 GGG GAA ATC AAT CAT AGT GGA AGC ACC AAC TAC AAC CCG TCC CTC AAG 192 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 AGT CGA GTC ACC ATA TCA GTA GAC ACG TCC AAG AAC CAG TTC TCC CTG 240 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 AAA CTG AAC TCT GTG ACC GCC GCG GAC ACG GCT GTG TAT TAC TGT GCG 288 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 AGG GCC CCA GAG TAT AAA TGG AAG TAT CAT GGG GAC TGG TTC GAC CCC 336 Arg Ala Pro Glu Tyr Lys Trp Lys Tyr His Gly Asp Trp Phe Asp Pro 100 105 110 TGG GGC CAA GGT ACC ACT GTC ACC GTC TCC TCA 369 Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 4) rNtORh=TIOH POUR LA aQ ID Mo: 4: (i) CARACTERISTIQUES DE LA SEQUENCE: (A) LONGUEUR: 123 acides aminés (B) TYPE: acide aminé (D) CONFIGURATION: linéaire (xi) DESCRIPTION DE LA SEQUENCE:SEQ ID NO: 4: Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr cys Thr Val Tyr Gly Gly Ser Phe Ser Gly Tyr 20 25 30 Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Ala Pro Glu Tyr Lys Trp Lys Tyr His Gly Asp Trp Phe Asp Pro 100 105 110 Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 115 120 5) ISPORMSIoN PoUR LA 8eQ ID NO: 5: (i) CARACTERISTIQUES DE LA SEQUENCE: (A) LONGUEUR: 717 paires de bases (B) TYPE: acide nucléique (C) NOMBRE DE BRINS: double (D) CONFIGURATION: linéaire (ix) CARACTERISTIQUE ADDITIONELLE: (A) NOM/CLE: matpeptide (B) EMPLACEMENT: 58..717 (D) AUTRES RENSEIGNEMENTS: /produit= Chaine légère d'immunoglobuline (ix) CARACTERISTIQUE ADDITIONELLE: (A) NOM/CLE: sigpeptide (B) EMPLACEMENT: 1..58 (xi) DESCRIPTION DE LA SEQUENCE:SEQ ID NO: 5: ATG GGA TGG AGC TGT ATC ATC CTC TTC TTG GTA GCA ACA GCT ACA GGT 48 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly -19 -15 -10 -5 GTC CAC TCC GAC ATC GAG CTC ACT CAG GAC CCT GCT GTG TCT GTG GCC 96 Val His Ser Asp Ile Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala 1 5 10 TTG GGA CAG ACA GTC AGG ATC ACA TGC CAA GGA GAC AGC CTC AGA ACC 144 Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Thr 15 20 25 TAT TAT GCA AGC TGG TAC CAG CAG AAG CCA GGA CAG GCA CCT GTA CTT 192 Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu 30 35 40 45 GTC ATC TAT GGT AAA AAC AAC CGG CCC TCA GGG ATC CCA GAC CGA TTC 240 Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe 50 55 60 TCT GGC TCC AGC TCA GGA AAC ACA GCT TCC TTG ACC ATC ACT GGG GCT 288 Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala 65 70 75 CAG GCG GAA GAT GAG GCT GAC TAT TTC TGT AAC AGC GGT GGG AAG GTG 336 Gln Ala Glu Asp Glu Ala Asp Tyr Phe Cys Asn Ser Gly Gly Lys Val 80 85 90 TTC GGC GGA GGG ACC AAG CTG ACC GTC CTA GGT CAG CCC AAG GCT GCC 384 Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 95 100 105 CCC TCG GTC ACT CTG TTC CCG CCC TCC CTC GAG GAG CTT CAA GCC AAC 432 Pro Ser Val Thr Leu Phe Pro Pro Ser Leu Glu Glu Leu Gln Ala Asn 110 115 120 125 AAG GCC ACA CTC GAG GAG CTT CAA GCC AAC AAG GCC ACA CTA GTG TGT 480 Lys Ala Thr Leu Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 130 135 140 CTG ATC AGT GAC TTC TAC CCG GGA GCT GTG ACA TTG GCT TGG AAG GCA 528 Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Leu Ala Trp Lys Ala 145 150 155 GAT GGC AGG CCC GTC AAG GCG GGA GTG GAG ACC AAC AAA CCC TCC AAA 576 Asp Gly Arg Pro Val Lys Ala Gly Val Glu Thr Asn Lys Pro Ser Lys 160 165 170 CAG AGC AAC AAC AAG TAC GCG GCC AGC AGC TAC CTG AGC CTG ACG CCC 624 Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 175 180 185 GAG CAG TGG AAG TCC CAC AGA AGC TAC AGC TGC CAG GTC ACG CAT GAA 672 Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu 190 195 200 205 GGG AGC ACT GCA GAG AAG ACG GTG GCC CCT GCA GAA TGT TCA TA 717 Gly Ser Thr Ala Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 210 215 220 6) IN-ORYATION Pool LA Uq ID Mc: 6: (i) CARACTERISTIQUES DE LA SEQUENCE: (A) LONGUEUR: 238 acides aminés (B) TYPE: acide aminé (D) CONFIGURATION: linéaire (xi) DESCRIPTION DE LA SEQUENCE: SEQ ID NO: 6:: Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly -19 -15 -10 -5 Val His Ser Asp Ile Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala 1 5 10 Leu Gly Gln Thr Val Arg Ile Thr cys Gln Gly Asp Ser Leu Arg Thr 15 20 25 Tyr Tyr Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu 30 35 40 45 Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe 50 55 60 Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala 65 70 75 Gln Ala Glu Asp Glu Ala Asp Tyr Phe Cys Asn Ser Gly Gly Lys Val 80 85 90 Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 95 100 105 Pro Ser Val Thr Leu Phe Pro Pro Ser Leu Glu Glu Leu Gln Ala Asn 110 115 120 125 Lys Ala Thr Leu Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys 130 135 140 Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Leu Ala Trp Lys Ala 145 150 155 Asp Gly Arg Pro Val Lys Ala Gly Val Glu Thr Asn Lys Pro Ser Lys 160 165 170 Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro 175 180 185 Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu 190 195 200 205 Gly Ser Thr Ala Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 210 215 7) INVOREASIOX POUR LA SZQ IDMO: 7: (i) CARACTERISTIQUES DE LA SEQUENCE: (A) LONGUEUR: 1419 paires de bases (B) TYPE: acide nucléique (C) NOMBRE DE BRINS: double (D) CONFIGURATION: linéaire (ix) CARACTERISTIQUE ADDITIONELLE: (A) NOM/CLE: matpeptide (B) EMPLACEMENT: 58..1419 (D) AUTRES RENSEIGNEMENTS: /produit= Chaine lourde d' irnrnoglobuline (ix) CARACTERISTIQUE ADDITIONELLE: (A) NOM/CLE: sigqeptide (B) EMPLACEMENT: 1..57 (xi) DESCRIPTION DE LA SEQUENCE:SEQ ID NO: 7: ATG GGA TGG AGC TGT ATC ATC CTC TTC TTG GTA GCA ACA GCT ACA GGT 48 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly -19 -15 -10 -5 GTC CAC TCC CAG GTC CAA CTG CAG CAG TGG GGC GCA GGA CTG TTG AAG 96 Val His Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys 1 5 10 CCT TCG GAG ACC CTG TCC CTC ACC TGC ACT GTC TAT GGT GGG TCC TTC 144 Pro Ser Glu Thr Leu Ser Leu Thr cys Thr Val Tyr Gly Gly Ser Phe 15 20 25 AGT GGT TAC TAC TGG AGC TGG ATC CGC CAG CCC CCA GGG AAG GGG CTG 192 Ser Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 30 35 40 45 GAG TGG ATT GGG GAA ATC AAT CAT AGT GGA AGC ACC AAC TAC AAC CCG 240 Glu Trp Ile Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro 50 55 60 TCC CTC AAG AGT CGA GTC ACC ATA TCA GTA GAC ACG TCC AAG AAC CAG 288 Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln 65 70 75 TTC TCC CTG AAA CTG AAC TCT GTG ACC GCC GCG GAC ACG GCT GTG TAT 336 Phe Ser Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 80 85 90 TAC TGT GCG AGG GCC CCA GAG TAT AAA TGG AAG TAT CAT GGG GAC TGG 384 Tyr Cys Ala Arg Ala Pro Glu Tyr Lys Trp Lys Tyr His Gly Asp Trp 95 100 105 TTC GAC CCC TGG GGC CAA GGT ACC ACT GTC ACC GTC TCC TCA GCC TCC 432 Phe Asp Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 110 115 120 125 ACC AAG GGC CCA TCG GTC TTC CCC CTG GCA CCC TCC TCC AAG AGC ACC 480 Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 130 135 140 TCT GGG GGC ACA GCG GCC CTG GGC TGC CTG GTC AAG GAC TAC TTC CCC 528 Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 145 150 155 GAA CCG GTG ACG GTG TCG TGG AAC TCA GGC GCC CTG ACC AGC GGC GTG 576 Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 160 165 170 CAC ACC TTC CCG GCT GTC CTA CAG TCC TCA GGA CTC TAC TCC CTC AGC 624 His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 175 180 185 AGC GTG GTG ACC GTG CCC TCC AGC AGC TTC GGC ACC CAG ACC TAC ATC 672 Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 190 195 200 205 TGC AAC GTG AAT CAC AAG CCC AGC AAC ACC AAG GTG GAC AAG AAA GCA 720 Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Ala 210 215 220 GAG CCC AAA TCT TGT GAC AAA ACT CAC ACA TGC CCA CCG TGC CCA GCA 768 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 225 230 235 CCT GAA CTC CTG GGG GGA CCG TCA GTC TTC CTC TTC CCC CCA AAA CCC 816 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 240 245 250 AAG GAC ACC CTC ATG ATC TCC CGG ACC CCT GAG GTC ACA TGC GTG GTG 864 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 255 260 265 GTG GAC GTG AGC CAC GAA GAC CCT GAG GTC AAG TTC AAC TGG TAC GTG 912 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 270 275 280 285 GAC GGC GTG GAG GTG CAT AAT GCC AAG ACA AAG CCG CGG GAG GAG CAG 960 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 290 295 300 TAC AAC AGC ACG TAC CGG GTG GTC AGC GTC CTC AAA GTC CTG CAC CAG 1008 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Lys Val Leu His Gln 305 310 315 GAC TGG CTG AAT GGC AAG GAG TAC AAG TGC AAG GTC TCC AAC AAA GCC 1056 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 320 325 330 CTC CCA GCC CCC ATC GAG AAA ACC ATC TCC AAA GCC AAA GGG CAG CCC 1104 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 335 340 345 CGA GAA CCA CAG GTG TAC ACC CTG CCC CGA TCC CGG GAT GAG CTG ACC 1152 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 350 355 360 365 AAG AAC CAG GTC AGC CTG ACC TGC CTG GTC AAA GGC TTC TAT CCC AGC 1200 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 370 375 380 GAC ATC GCC GTG GAG TGG GAG AGC AAT GGG CAG CCG GAG AAC AAC TAC 1248 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 385 390 395 AAG ACC ACG CCT CCC GTG CTG GAC TCC GAC GGC TCC TTC TTC CTC TAC 1296 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 400 405 410 AGC AAG CTC ACC GTG GAC AAG AGC AGG TGG CAG CAG GGG AAC GTC TTC 1344 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 415 420 425 TCA TGC TCC GTG ATG CAT GAG GCT CTG CAC AAC CAC TAC ACG CAG AAG 1392 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 430 435 440 445 AGC CTC TCC CTG TCT CCG GGT AAA TG 1419 Ser Leu Ser Leu Ser Pro Gly Lys 450 8) XSYORYSIoY POOR LA SZQ ID NO: 8: (i) CARACTERISTIQUES DE LA SEQUENCE: (A) LONGUEUR: 472 acides aminés (B) TYPE: acide aminé (D) CONFIGURATION: linéaire (xi) DESCRIPTION DE LA SEQUENCE:SEQ ID NO: 8: Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly -19 -15 -10 -5 Val His Ser Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys 1 5 10 Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Tyr Gly Gly Ser Phe 15 20 25 Ser Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu 30 35 40 45 Glu Trp Ile Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro 50 55 60 Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln 65 70 75 Phe Ser Leu Lys Leu Asn Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 80 85 90 Tyr Cys Ala Arg Ala Pro Glu Tyr Lys Trp Lys Tyr His Gly Asp Trp 95 100 105 Phe Asp Pro Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser 110 115 120 125 Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 130 135 140 Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 145 150 155 Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 160 165 170 His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 175 180 185 Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 190 195 200 205 Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Ala 210 215 220 Glu Pro Lys Ser cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 225 230 235 Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 240 245 250 Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 255 260 265 Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 270 275 280 285 Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 290 295 300 Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Lys Val Leu His Gln 305 310 315 Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 320 325 330 Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 335 340 345 Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 350 355 360 365 Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 370 375 380 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 385 390 395 Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 400 405 410 Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 415 420 425 Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 430 435 440 445 Ser Leu Ser Leu Ser Pro Gly Lys 450