LISTE DE SEQUENCES (1) INFORMATIONS GENERALES: (i) DEPOSANT: (A) NOM: INSTITUT PASTEUR (B) RUE: 28 RUE DU DOCTEUR ROUX (C) VILLE: PARIS (E) PAYS: FRANCE (F) CODE POSTAL: 75015 (A) NOM: UNIVERSITE PARIS 7 (B) RUE: 1 PLACE JUSSIEU (C) VILLE: PARIS (E) PAYS: FRANCE (F) CODE POSTAL: 75005 (ii) TITRE DE L' INVENTION: SEQUENCES EN AMONT DU GENE SM22 (iii) NOMBRE DE SEQUENCES: 3 (iv) FORME DECHIFFRABLE PAR ORDINATEUR: (A) TYPE DE SUPPORT: Floppy disk (B) ORDINATEUR: IBM PC compatible (C) SYSTEME D' EXPLOITATION: PC-DOS/MS-DOS (D) LOGICIEL: PatentIn Release +1.0, Version #1.30 (OEB) INFORMATIONS POUR LA SEQ ID NO; I: (i) CARACTERISTIQUES DE LA SEQUENCE: (A) LONGUEUR: 6261 paires duc bases (B) TYPE : nucléotide (C) NOMBRE DE BRINS : double (D) CONFIGURATION : linéaire (ti) TYPE DE MOLECULE : ADN (génomique) (iii) HYPOTHETIQUE:NON (vi) ORIGINE (A) ORGANISME: SOURIS TCTAGAGGCC ACGGAACGGT GCCAAGCACA CAGTCCCTTT TGCCTCTTTC ACGGGAGCAG GAGTCCCAGT GCCTGTCGTG GAAAGGGAGG AACATGCCAG GTCCCTGTGT GTCCTTGGCC CTGTCTCACC AAAGGACTCA GGGCTGGTTT CTGAGTTTCC GTCCAGTATT TAGCCAAGTC CTGTGTTAGT CACGTAGGCC TAAGAGCCTT GGCGTTTACG GAGTCACCCA GCTCTGGCCC CTGGCATTCT GGTCCTTGGC GTTTACAGAG TCACCCAGCT CCAGGCCCCT GGCACTTTGG TACTTGGTTG CCCTTCACTC CACCAGGTCC ATTCCAGATG CCAAGAGTGG GCCCCAGGAA TGTGTTTCCT TCTCTCCACC ATGTTTTTAT AGCTCTTGGG CTGGGAGAAG AGGCGGGTCT GGGTCTTTGT TTCTGAGCTT TGTTCTATGT TCCTCCATGC TACGGTTGCA ATTGTTTTCT ATGAACGAGT ACATTCAATA AAGACAACCA GACCTGGGAT TTGGGGTCTT ACTGATGTGT TGGGAGGTGC AGGAGCCTCC GTGTCCCATT TATTTTGGCC TTCCCGTCTC GTTTCTGTGC GTGGCTACAT TGGGAATGAC CTTCCTTGAT CCCACCAAGC CACCCATTGA TTCTGTAAAC AtGTGACCCT TGCTCCAAGC ATTGCTTACA GGAGCAGGAT ACTGAAAGTG TGTCTGTGCC CTCTCCTGAT AACCCCTCCC TTCAGCAGGC ACACAGCACC TGACTACCCA CCACGTATGT AAACGTCAGT ATCCTTTCCA GCCAGCTCTG CAGATGGGTG TCCAGGCTGT GCATGATGCA CCTCAAGTGG GCAGAGCTTG CAGGCCAAGG TTTTAAAGGC TGTTCAGGAA TGGATGGCAA GCAGGATCTA AGAGGAGGGG GGGTTGTTGT TGTTTGGGGG GGGGGTGGTT TTGGTTTGTT TTTTTTGAGA CAGGGTTTCT CTGTGTGGCC CTGGCCCTCC TGGAACCCAC TCTGTAGACC AGGCTGGCCT TGAACTCAGA AATCTGCCTG CCTCTGCCTC CCGAGTGCTG GGATTAAAGG CGTGTGCCCA TCGAGGAGGG AGATTTTATT TAGATTATAA AAAGGACGGG ATTTGGGGAA TCCTGTCTAG TGAATTCAGG ACGTAATCAG TGGCTGGGAA GCAAGAGCTC TAGAGGAGCT CCAGCTTATT ATGACCCTTC CTTCAGATGC CACAAGGAGG TGCTGGAGTT CTATGCACCA ATAGCTTAAA CCAGCCAGGC TGGCTGTAGT GGATTGAGCG TCTGAGGCTG CACCTCTCTG GCCTGCAGCC AGTTCTGGGT GAGACTGACC CTGCCTGAGG GTTCTCTCCT TCCCTCTCTC TACTCCTTCC TCCCTCTCCC TCTCCCTCTC TCTGTTTCCT GAGGTTTCCA GAATTGGGGA TGGGACTCAG AGACACCACT AAAGCCTTAC CTTTTAAGAA GTTGCATTCA GTGAGTGTGT GAGACATAGC ACAGATAGGG GCAGAGGAGA GCTGGTTCTG TCTCCACTGT GlliGGTCTT GGGTACTGAA CTCAGACCAT CAGGTGTGAT AGCAGTTGTC TTTAACCCTA ACCCTGAGCC TGTCTCACCT GTCCCTTCCC AAGACCACTG AAGCTAGGTG CAAGATAAGT GGGGACCCTT TCTGAGGTGG TAGGATCTTT CACGATAAGG ACTATTTTGA AGGGAGGGAG GGTGACACTG TCCTAGTCCT CTTACCCTAG TGTCTCCAGC CTTGCCAGGC CTTAAACATC CGCCCATTGT CACCGCTCTA GAAGGGGCCA CCCTTGACTT GCTGCTAAAC AAGGCACTCC CTAGAGAAGA TACCATACCT GTGGGCAGGA TGACCCATGT TCTGCCATGC ACTTGGTAGC CTTGGAAAGG CCACTTTGAA CCTCAATTTT CTCAACTGTT AAATGGAGTG GTAACTGCTA TCTCATAATA AAGGGGAAGG TGAGGAAGGC GTTTGGATAG TGCCTGGTTG CGGCCAGGCT GCAGTCAAGA CTAGTTCCCA CCAACTCGAT TTTAAAGCCT TGCAAGAAGG TGGCTTGTTT GTCCCTTGCA GGTTCCTTTG CTCGGGCCAA ACTCTAGAAT GCCTCCCCCT TTCTTTCTCA TTGAAGAGCA GACCCAAGTC CGGGTAACAA GGAAGGGTTT CAGGGTCCTG CCCATAAAAG GTTTTTCCCG GCCGCCCTCA GCACCGCCCC GCCCCGACCC CCGCAGCATC TCCAAAGCAT GCAGAGAATG TCTCCGGCTG CCCCCGACAG ACTGCTCCAA CTTGGTGTCT TTCCCCAAAT ATGGAGCCTG TGTGGAGTGA GTGGGGCGGC CCGGGGTGGT GAGCCAAGCA GACTTCCATG GGCAGGGAGG GGCGCCACGG GGCGGCAGAG GGGTGACATC ACTGCCTAGG CGGCCTTTAA ACCCCTCACC CAGCCGGCGC CCCGGCCCGT CTGCCCCAGC CCAGACACCG AAGCTACTCT CCTTCCAGTC CACAAACGAC CAAGCCTTGT AAGTGCAAGT CATGGGAGCA GAAGGGCTGT GGGCTCAATT AGATCCCCTA GTCTCTTCTA GTTTGCTGGG TGGAATTGGG TCCCTAGAGA CCATTCTCTG TGTTAGACAA AAAGTCTGGG TTAAAATGCC TAGGATGATT TGACTGGGGC AAAAGAATAA ATGQGGTGAG AGGGAGGCTC AAATTCAGTC ACTGTCCCAC CCATAGGTGT ATGGGCTATG TGTTAGGCCC AAAGAGGTGA CAAATGAGGC CAAGGGAACA ACTCCATCTT TGGATCTCCA AGAAGGTGAG GGGCTAAGTT CTGGAAAGCA GTGACCCACT GATGGTCCCC AGGGCTAATG CAACTCGGGG GAGCCAGGAG GTAGCCCCCT CAGGCAGTGG AGGACTAAAG ATCTTATTTT TTGTAGCGCT AGGGATCAAA CCCCAGGGCG CTATGTGTGG CAGGCATGTG CTCCATCTAC CACAGAAGTT TAATCCTTCA GACTAGCCTG GGATAGGGCC TGCTTTTTCT TTCCTTTTCT CTCTCTCTCT CTCTCTCTCT CTCTCTCTCT CTCTCTCTCT CTCTCTCTTT CTTTCCTTTT CTCTCTTTCA CTCTCTCTTT CTAATTTCTT TTTCTTTTTT TCTTTCTTTT CTTTAGACAG GGTTTCTCTG TGTAGCCCTG GCTGTTCTGG AACTCACTCT TTAGACCAGG CTGGCCTCGA ATCTCAGAAA TCTACCTGCC TCTGCCTCCC AAGTGCTGGG ATTAAAGGCG TGTGCCACCA CTGCCCAGCT AAGGTTTGCT TTTTGATGGC AGCTTGGTCC AGTTTGAAAG TAGGAGGTCA GTCCACTGTA GGCAGATAGG TGACAGGTGG CAGATAGGTG ACAGATAGGT GACAGGTGGA GGAGCTTTGG AACTGGGACT GGACAGCCCT GGGACCCTGT TCCTCCCAAA GGGTCTTGGT GGTTCCCCTT GGGGCTCTCT MAGGATGTC AGTGGGCTGT TGCCACATCT ATATAAGAGG ACTAGTCTrC TGGAATTTAG GTGTGATCTC TCAGGGATGC AGAAATGCTC ACCCTTACTG TCATTTTATG GGCTGAGGTA CCACAGGCAG ATATACCCTG GTCTGCTTGT TGTCCAGGGT CTCTGCTACA TGGAGGCCCC TTTCCACAGC CTAACCTCTC TACCTGCTGA CAGGAGGGCT GGATGGCCAC AGGCATCCAA CGTGCGCATC ATGCAGGTGT TTTGCGTTGG AGCTTTTGTC TAGAAATACC CTGGTGGGCT GCCAAACCAC CACCCATATC CCTCTCTCCT CTCTGCTGCC TCTAAGATGA CAGCTTGATT TTTCTTATAG TGATTTTTTT TTTTGGTTTT GTTTTTTTGT TTGTTTTAAG TTAGCATACA AAGTAATACA TTTCATCATG GCATTTGGAC ATACATATAT ATTTTATTTG CTCTCCTGGC CTCTTCTCAA AGAGACTTCT CTGGAcTTTC TTGTATTTTT GGTTGTGAGC CTAGCCTTTA ACGGCTGAGC CATCTCTCCA GCCCTTCTTT GGACTTTCTA CTTCATACTT CCCACCAGTC TGGGAAGAAG GGCACATGGA ATCTTGAGAG CATGACCTGA CCCAGACCTG ACAGATGTCA AGGCTGCAGT GTATGCTCTT GTTCGTACGG CTTGTTCTTA GTCCTGCAGT TCAGAACTTT CTGGAGACTG AGAAGTGCAT GTGAGGACAC TCTCCTCCCA TCTTTTCCTC TAGTGGCTAG TGATGTTTGG TTTTTTGTTT TGAGACAGGG TTICTCTGTA TAGCCCTAGC TATCCTGGAA CTCACTTTGT AGATCAGGCT GGCCTCCAAC TCAGAAATCT GCCTGCCTCT GCCTCCCGAG TGCTGGGACT AAAGGCGTGC GCCACCACTG TCCAGTCAGG AGTAGAAGGA AACTGTAAGG TGCTTGAGAC AGGCTGAGTA GAGGCTAGGA GGAAGGGGCA CCGCAGTCAC CGGCTCCATG ACTCTGTGAC WTGTGGTT CCTTGTCGCA GCGGTTCCTG GTGGTGGTGG TGGTCGGGGG TTGGGGGGAG GGGGCAGGCC ACACAGTGGG GTGTGGGAGG GAATAGCTGT TGACAACTTC CCAACAGAAA CCAGGCTTTT GAGTCCTCCA GGGTAGCTTG AGAGGGTACT CAGAAAGCCG TGTCCATGTC CCCTTTCCTT CACCTCAGGG AAGTAAGTTG CCTATAGGGT TGTCATTTCA ATGAGGTCTT CTGGTTATTC TGTTTTTCTC TCAATGTTGG TGTTGGGCTC AGGGAATGCT TTGGAGAAGG TGGTGGGAAC TGGAGAAGGG AAGATCAGTT TACTGTGTAA ACTCACTGGT TAAAGTACCC CCTCCCTTCC ACCCTGCAAT ACACACACAC ACACACACAC ACACACACAC ACACACACAC ACCCCATCTC GAAGAGCTCT ATTAAGCTCC AGGTGCACTG TAGTTCACAG ACTGCATCTT CCAGGTTTGC TCCCACTTCA CTCCATGCTC ACACAATTTT TCTCTCAACC AATGACCTCT CAGAAGCAGG GGTTGGTTTG CAAAATTCTT CAGATACCTC AACAGATGGC ATCCCACTCA GGCTATCCCT GCTGACTAGG TCTGGCTCCA GCCCTGACTG TATCTACCCA GGGACCTACC TGCCTGCTTT GCTCCTATAG CCTTCCTCCG TGTCTGGGTC CCCAGAGAGC TGCCGGCATA GGCCTTTGAG GCAACAGCTG GCATACAGGC CAGGCTTCCC ATGCTCTGGC TAGCAGATTC TCTGCCCTGG AGGACTTTGA CTGCATGGTT TCTCTCACTG CTGCAACAGT CAGAGCTGGC CCACACGGGC ACAACAGCGC ACTTCCATCT GGGTCTCCCT GAGAATGCCG CTGTTTTCTG AGAACCCTTG GACTCTGGTG GCTTTATCAG GTCTTTTTGT CAGCTGCGCT TTGGGGGATG AACTTTGCTC TTCTGGCTTC TGGGTCAGAG GGTAAAGATT TGGTGGCAAC CGGTAGCTAG AGAAAGATAG CTACTGGCTG AATTTGGAGG ACATGGCTTC TGGAAAACCT CTCTAGTGCT TTTCTGGCTA GTCTTGGCAA AGTAAAAATG CTCTGATAGC CAGCCCGGGT GATGCAGGGC TTCCTGTTCG AGGCCTTTCT GTACAAAATT AGTGAGACAT TGCCTCAAAA CTATGAAACA AGCCAGACTC TGTTGAAGCA CGCCTTTAAT CCCAGCACTC AGGAGGCTGA AGCAGGCAAG ATCTCTGTTA GTTGGAGGCC AGTCTACAGG AAAGTTCTAC AACAGCAGAG GCCAGACAGT GCAACCCTTT CTGGGGGTGT GGGGGAGGAA AACCCAACAA AAACACAAAC TATAAAACAA AGAGAAGGCC GAGGACAAAG CTTAGCAATG CATACTTCCC TTTCTATGTG AAGCCCTGGG CTCCACCAGT ACTGCAGAAA GAAGCAAGCA ATGAGGGACA GGAGGTTGGC TCTAGGCCCA GGGGTTGTCA AAATAGTCCA CAGGCCAAAG GCAGCCTGAT GTCTGTTTTT ATAAACAAAA TTTTATTGGC ACACATTGGT TATGTATCAG CTAGGCTATT TTCATTACAA TAGAGGCCAT ATGGTCTGTA AAGTCTAAAA TATTTACTCT GCTGTTTTAC ATAAAAAGTT GACAGACTCT TGCTCTAGAC TGACAAATAT CTAAGACCTT GTTTTCTGAG GTTCAAGTTT CAGAGGGGTC TCTGCAGCAA GTGGGTAAAG CTGGTCTAGG TCATGCTATG ATGTCTAGGG TCCCCTCAGA GTGGAAGGCC TGCTTAGCAC AAATGAAGTA AAGTAACTTG CTGGCTCTTT GTTCTTTTCT CCACACTCTA TACTTTAGCT CTGCCTCAACATG (2) INFORMATIONS POUR LA SEQ ID NO: 2: (i) CARACTERISTIQUES DE LA SEQUENCE: (A) LONGUEUR: 2190 paires de bases (B) TYPE: nucleotide (C) NOMBRE DE BRINS: double (D) CONFIGURATION: linéaire (ii) TYPE DE MOLECULE: ADN (génomique) (iii) HYPOTHETIQUE: NON (vi) ORIGINE: (A) ORGANISME: SOURIS (xi) DESCRIPTION DE LA SEQUENCE: SEQ ID NO:2 GGGCCCCAGG AATGTGTTTC CTTCTCTCCA CCATGTTTTT ATAGCTCTTG GGCTGGGAGA 60 AGAGGCGGGT CTGGGTCTTT GTTTCTGAGC TTTGTTCTAT GTTCCTCCAT GCTACGGTTG 120 CAATTGTTTT CTATGAACGA GTACATTCAA TAAAGACAAC CAGACCTGGG ATTTGGGGTC 180 TTACTGATGT GTTGGGAGGT GCAGGAGCCT CCGTGTCCCA TTTATTTTGG CCTTCCCGTC 240 TCGTTTCTGT GCGTGGCTAC ATTGGGAATG ACCTTCCTTG ATCCCACCAA GCCACCCATT 300 GATTCTGTAA ACATGTGACC CTTGCTCCAA GCATTGCTTA CAGGAGCAGG ATACTGAAAG 360 TGTGTCTGTG CCCTCTCCTG ATAACCCCTC CCTTCAGCAG GCACACAGCA CCTGACTACC 420 CACCACGTAT GTAAACGTCA GTATCCTTTC CAGCCAGCTC TGCAGATGGG TGTCCAGGCT 480 GTGCATGATG CACCTCAAGT GGGCAGAGCT TGCAGGCCAA GGTTTTAAAG GCTGTTCAGG 540 AATGGATGGC AAGCAGGATC TAAGAGGAGG GGGGGTTGTT GTTGTTTGGG GGGGGGGTGG 600 TTTTGGTTTG TTTTTTTTGA GACAGGGTTT CTCTGTGTGG CCCTGGCCCT CCTGGAACCC 660 ACTCTGTAGA CCAGGCTGGC CTTGAACTCA GAAATCTGCC TGCCTCTGCC TCCCGAGTGC 720 TGGGATTAAA GGCGTGTGCC CATCGAGGAG GGAGATTTTA TTTAGATTAT AAAAAGGACG 780 GGATTTGGGG AATCCTGTCT AGTGAATTCA GGACGTAATC AGTGGCTGGG AAGCAAGAGC 840 TCTAGAGGAG CTCCAGCTTA TTATGACCCT TCCTTCAGAT GCCACAAGGA GGTGCTGGAG 900 TTCTATGCAC CAATAGCTTA AACCAGCCAG GCTGGCTGTA GTGGATTGAG CGTCTGAGGC 960 TGCACCTCTC TGGCCTGCAG CCAGTTCTGG GTGAGACTGA CCCTGCCTGA GGGTTCTCTC 1020 CTTCCCTCTC TCTACTCCTT CCTCCCTCTC CCTCTCCCTC TCTCTGTTTC CTGAGGTTTC 1080 CAGAATTGGG GATGGGACTC AGAGACACCA CTAAAGCCTT ACCTTTTAAG AAGTTGCATT 1140 CAGTGAGTGT GTGAGACATA GCACAGATAG GGGCAGAGGA GAGCTGGTTC TGTCTCCACT 1200 GTGTTTGGTC TTGGGTACTG AACTCAGACC ATCAGGTGTG ATAGCAGTTG TCTTTAACCC 1260 TAACCCTGAG CCTGTCTCAC CTGTCCCTTC CCAAGACCAC TGAAGCTAGG TGCAAGATAA 1320 GTGGGGACCC TTTCTGAGGT GGTAGGATCT TTCACGATAA GGACTATTTT GAAGGGAGGG 1380 AGGGTGACAC TGTCCTAGTC CTCTTACCCT AGTGTCTCCA GCCTTGCCAG GCCTTAAACA 1440 TCCGCCCATT GTCACCGCTC TAGAAGGGGC CACCCTTGAC TTGCTGCTAA ACAAGGCACT 1500 CCCTAGAGAA GATACCATAC CTGTGGGCAG GATGACCCAT GTTCTGCCAT GCACTTGGTA 1560 GCCTTGGAAA GGCCACTTTG AACCTCAATT TTCTCAACTG TTAAATGGAG TGGTAACTGC 1620 TATCTCATAA TAAAGGGGAA CGTGAGGAAG GCGTTTGGAT AGTGCCTGGT TGCGGCCAGG 1680 CTGCAGTCAA GACTAGTTCC CACCAACTCG ATTTTAAAGC CTTGCAAGAA GGTGGCTTGT 1740 TTGTCCCTTG CAGGTTCCTT TGCTCGGGCC AAACTCTAGA ATGCCTCCCC CTTTCTTTCT 1800 CATTGAAGAG CAGACCCAAG TCCGGGTAAC AAGGAAGGGT TTCAGGGTCC TGCCCATAAA 1860 AGGTTTTTCC CGGCCGCCCT CAGCACCGCC CCGCCCCGAC CCCCGCAGCA TCTCCAAAGC 1920 ATGCAGAGAA TGTCTCCGGC TGCCCCCGAC AGACTGCTCC AACTTGGTGT CTTTCCCCAA 1980 ATATGGAGCC TGTGTGGAGT GAGTGGGGCG GCCCGGGGTG GTGAGCCAAG CAGACTTCCA 2040 TGGGCAGGGA GGGGCGCCAC GGGGCGGCAG AGGGGTGACA TCACTGCCTA GGCGGCCTTT 2100 AAACCCCTCA CCCAGCCGGC GCCCCGGCCC GTCTGCCCCA GCCCAGACAC CGAAGCTACT 2160 CTCCTTCCAG TCCACAAACG ACCAAGCCTT 2190 (2) INFORMATIONS POUR LA SEQ ID NO: 3 (i) CARACTERISTIQUES DE LA SEQUENCE: (A) LONGUEUR: 785 paires de bases (B) TYPE: nucléotide (C) NOMBRE DE BRINS: double (D) CONFIGURATION: linéaire (ii) TYPE DE MOLECULE: ADN ( gnomique) (iii) HYPOTHETIQUE: NON (vi) ORIGINE: (A) ORGANISME: SOURIS (xi) DESCRIPTION DE LA SEQUENCE: SEQ ID No:3: GGGCCCCAGG AATGTGTTTC CTTCTCTCCA CCATGTTTTT ATAGCTCTTG GGCTGGGAGA 60 AGAGGCGGGT CTGGGTCTTT GTTTCTGAGC TTTGTTCTAT GTTCCTCCAT GCTACGGTTG 120 CAATTGTTTT CTATGAACGA GTACATTCAA TAAAGACAAC CAGACCTGGG ATTTGGGGTC 180 TTACTGATGT GTTGGGAGGT GCAGGAGCCT CCGTGTCCCA TTTATTTTGG CCTTCCCGTC 240 TCGTTTCTGT GCGTGGCTAC ATTGGGAATG ACCTTCCTTG ATCCCACCAA GCCACCCATT 300 GATTCTGTAA ACATGTGACC CTTGCTCCAA GCATTGCTTA CAGGAGCAGG ATACTGAAAG 360 TGTGTCTGTG CCCTCTCCTG ATAACCCCTC CCTTCAGCAG GCACACAGCA CCTGACTACC 420 CACCACGTAT GTAAACGTCA GTATCCTTTC CAGCCAGCTC TGCAGATGGG TGTCCAGGCT 480 GTGCATGATG CACCTCAAGT GGGCAGAGCT TGCAGGCCAA GGTTTTAAAG GCTGTTCAGG 540 AATGGATGGC AAGCAGGATC TAAGAGGAGG GGGGGTTGTT GTTGTTTGGG GGGGGGGTGG 600 TTTTGGTTTG TTTTTTTTGA GACAGGGTTT CTCTGTGTGG CCCTGGCCCT CCTGGAACCC 660 ACTCTGTAGA CCAGGCTGGC CTTGAACTCA GAAATCTGCC TGCCTCTGCC TCCCGAGTGC 720 TGGGATTAAA GGCGTGTGCC CATCGAGGAG GGAGATTTTA TTTAGATTAT AAAAAGGACG 780 WATT: 785 References Almendral, J.M., Santaren, J.F., Perern, J., Zerial, M. and Brnvo, R. (1989). Expression, cloning and cDNA scquence of a fibroblast serum-regulated gene encoding a putative actinassociated protcin (p27). Exp. Cell Res., 181, 518-530.