Utilize the input text as a context reference, choose the right relationship between Orkambi and Vertex Pharmaceuticals from the options. Options: product/material produced, manufacturer, distributed by, industry, position held, original broadcaster, owned by, founded by, distribution format, headquarters location, stock exchange, currency, parent organization, chief executive officer, director/manager, owner of, operator, member of, employer, chairperson, platform, subsidiary, legal form, publisher, developer, brand, business division, location of formation, creator.

Vertex Pharmaceuticals jumped 4.0 percent after announcing that the US Food and Drug Administration approved its Orkambi drug to treat cystic fibrosis.

Answer: manufacturer