Utilize the input text as a context reference, choose the right relationship between Twitter and SAN FRANCISCO from the options. Options: product/material produced, manufacturer, distributed by, industry, position held, original broadcaster, owned by, founded by, distribution format, headquarters location, stock exchange, currency, parent organization, chief executive officer, director/manager, owner of, operator, member of, employer, chairperson, platform, subsidiary, legal form, publisher, developer, brand, business division, location of formation, creator.

SAN FRANCISCO (Reuters) - Critics have long lamented that Twitter Inc (TWTR.N) is difficult to use and has had trouble defining itself, which is why it has not expanded its audience.

Answer: headquarters_location