Given the input sentence, please extract the subject and object containing a certain relation in the sentence according to the following relation types, in the format of "relation1: word1, word2; relation2: word3, word4". Relations include: product/material produced; manufacturer; distributed by; industry; position held; original broadcaster; owned by; founded by; distribution format; headquarters location; stock exchange; currency; parent organization; chief executive officer; director/manager; owner of; operator; member of; employer; chairperson; platform; subsidiary; legal form; publisher; developer; brand; business division; location of formation; creator.

In the retinal disease area in the second quarter of this year, the European Commission granted orphan medicinal product designation to ADX-2191 for the treatment of retinal detachment, opening a new market opportunity for ADX-2191 in the European Union as drugs receiving the orphan medicinal product designation are eligible to protocol assistance, research funding and upon approval, 10 years of EU market exclusivity.

Answer: operator: EU, European Union