Utilize the input text as a context reference, choose the right relationship between Wynn Macau and Macau from the options. Options: product/material produced, manufacturer, distributed by, industry, position held, original broadcaster, owned by, founded by, distribution format, headquarters location, stock exchange, currency, parent organization, chief executive officer, director/manager, owner of, operator, member of, employer, chairperson, platform, subsidiary, legal form, publisher, developer, brand, business division, location of formation, creator.

Wynn created its first Macau casino in 2006 with Encore at Wynn Macau opening in 2010.

Answer: headquarters_location