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CAMBRIDGE, Mass.--(BUSINESS WIRE)--Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), the leading RNAi therapeutics company, today reported its consolidated financial results for the third quarter 2020 and reviewed recent business highlights. We are extremely pleased with the performance of ONPATTRO and GIVLAARI in the third quarter, reflecting strong commercial execution and improving market conditions following the more challenging COVID-19 pandemic phase experienced in the second quarter. Were also excited about the recent positive CHMP opinions for OXLUMO and LEQVIO, moving these potentially transformative investigational RNAi therapeutics closer to approval. We believe that this positions Alnylam to potentially exit 2020 with four revenue-generating products bolstering our sustained growth, said John Maraganore, Ph.D., Chief Executive Officer of Alnylam. In addition, our robust late-stage pipeline of investigational medicines continued to advance in the quarter. Notably, we achieved positive results from the ILLUMINATE-B study demonstrating efficacy and safety for our investigational RNAi therapeutic lumasiran in children under the age of six, including infants. We also achieved continued enrollment in our APOLLO-B and HELIOS-B Phase 3 studies of patisiran and vutrisiran, respectively, in development for the treatment of ATTR amyloidosis with cardiomyopathy. With our recent progress, we now expect to exceed our Alnylam 2020 vision and goals of building a multi-product, global biopharma company with a deep clinical pipeline and a robust, organic product engine to drive future sustainable innovation and value creation. Finally, we look forward to highlighting further progress and future plans at our upcoming virtual R&D Day event in December. Third Quarter 2020 and Recent Significant Corporate Highlights Commercial Performance ONPATTRO GIVLAARI R&D Highlights Additional Business Updates Upcoming Events In addition, in late 2020, Alnylam intends to: Financial Results for the Quarter Ended September 30, 2020 The third quarter was very strong, with a rebound in ONPATTRO sales growth, particularly in the U.S., and continued impressive early performance with GIVLAARI. While the pandemic headwinds havent completely receded, we believe our teams have been very effective in meeting the needs of patients. As a result of this continued strength and our cautious optimism for the fourth quarter, we are again revising our full-year revenue guidance for ONPATTRO, increasing the range from $280-$300 million to $295-$310 million, said Jeff Poulton, Chief Financial Officer of Alnylam. Beyond the commercial business, we also closed the $150 million R&D funding component of the Blackstone strategic financing collaboration, finalizing the last piece of a broad relationship that we believe secures our path to self-sustainability without the need for future equity offerings. Looking ahead, we believe we are well positioned to continue executing on our current commercial portfolio, with potential for two additional RNAi therapeutics coming to market, and advancing our broad pipeline of investigational programs to drive future growth. Financial Highlights (in thousands, except per share amounts) Three Months Ended September 30, 2020 2019 Net product revenues $ 99,206 $ 46,066 ONPATTRO net product revenues $ 82,516 $ 46,066 GIVLAARI net product revenues $ 16,690 $ Net revenue from collaborations $ 26,647 $ 23,995 Cost of goods sold $ 21,797 $ 5,213 GAAP research and development expenses $ 161,783 $ 160,796 Non-GAAP research and development expenses $ 148,080 $ 138,059 GAAP selling, general and administrative expenses $ 167,472 $ 120,351 Non-GAAP selling, general and administrative expenses $ 114,498 $ 97,079 GAAP operating loss $ (225,199) $ (216,299) Non-GAAP operating loss $ (158,522) $ (170,290) GAAP net loss $ (253,291) $ (208,535) Non-GAAP net loss $ (183,597) $ (162,526) GAAP net loss per common share - basic and diluted $ (2.18) $ (1.92) Non-GAAP net loss per common share - basic and diluted $ (1.58) $ (1.50) September 30, 2020 December 31, 2019 Cash, cash equivalents and marketable securities $ 1,833,876 $ 1,536,162 Net Product Revenues Net Revenues from Collaborations Research & Development (R&D) and Selling, General & Administrative (SG&A) Expenses Cash and Investments A reconciliation of GAAP to non-GAAP results for the current quarter is included in the tables of this press release. 2020 Updated Financial Guidance Full year 2020 financial guidance consists of the following: Item Provided 8/6/2020 ($ millions) Updated 11/5/2020 ($ millions) ONPATTRO net product revenues $280 - $300 $295 - $310 GIVLAARI net product revenues No guidance provided Unchanged Net revenues from collaborations $100 - $150 Unchanged GAAP R&D and SG&A expenses $1,130 - $1,225 $1,160 - $1,255 Non-GAAP R&D and SG&A expenses* $1,000 - $1,075 Unchanged *Excludes $160-$180 million of expenses primarily related to stock-based compensation and a change in estimate of contingent liabilities from projected GAAP R&D and SG&A expenses. The strategic financing collaboration with Blackstone under which Alnylam will receive up to $2 billion is expected to enable Alnylams achievement of a self-sustainable financial profile without need for future equity financings. Use of Non-GAAP Financial Measures This press release contains non-GAAP financial measures, including expenses adjusted to exclude certain non-cash expenses and non-recurring gains outside the ordinary course of the Companys business. These measures are not in accordance with, or an alternative to, GAAP, and may be different from non-GAAP financial measures used by other companies. The items included in GAAP presentations but excluded for purposes of determining non-GAAP financial measures for the periods presented in the press release are stock-based compensation expenses, unrealized gains on marketable equity securities, costs associated with our strategic financing collaboration, loss on contractual settlement and change in estimate of contingent liabilities. The Company has excluded the impact of stock-based compensation expense, which may fluctuate from period to period based on factors including the variability associated with performance-based grants for stock options and restricted stock units and changes in the Companys stock price, which impacts the fair value of these awards. The Company has excluded the impact of the unrealized gains on marketable equity securities, costs associated with our strategic financing collaboration, loss on contractual settlement and change in estimate of contingent liabilities because the Company believes these items are non-recurring transactions outside the ordinary course of the Companys business. The Company believes the presentation of non-GAAP financial measures provides useful information to management and investors regarding the Companys financial condition and results of operations. When GAAP financial measures are viewed in conjunction with non-GAAP financial measures, investors are provided with a more meaningful understanding of the Companys ongoing operating performance and are better able to compare the Companys performance between periods. In addition, these non-GAAP financial measures are among those indicators the Company uses as a basis for evaluating performance, allocating resources and planning and forecasting future periods. Non-GAAP financial measures are not intended to be considered in isolation or as a substitute for GAAP financial measures. A reconciliation between GAAP and non-GAAP measures is provided later in this press release. Conference Call Information Management will provide an update on the Company and discuss third quarter 2020 results as well as expectations for the future via conference call on Thursday, November 5, 2020 at 8:30 am ET. To access the call, please dial 800-239-9838 (domestic) or +1-323-794-2551 (international) five minutes prior to the start time and refer to conference ID 6976021. A replay of the call will be available beginning at 11:30 am ET on the day of the call. To access the replay, please dial 888-203-1112 (domestic) or +1-719-457-0820 (international) and refer to conference ID 6976021. A live audio webcast of the call will be available on the Investors section of the Companys website at www.alnylam.com/events. An archived webcast will be available on the Alnylam website approximately two hours after the event. About ONPATTRO (patisiran) ONPATTRO is an RNAi therapeutic that was approved in the United States and Canada for the treatment of the polyneuropathy of hATTR amyloidosis in adults. ONPATTRO is also approved in the European Union, Switzerland and Brazil for the treatment of hATTR amyloidosis in adults with Stage 1 or Stage 2 polyneuropathy, and in Japan for the treatment of hATTR amyloidosis with polyneuropathy. ONPATTRO is an intravenously administered RNAi therapeutic targeting transthyretin (TTR). It is designed to target and silence TTR messenger RNA, thereby blocking the production of TTR protein before it is made. ONPATTRO blocks the production of TTR in the liver, reducing its accumulation in the bodys tissues in order to halt or slow down the progression of the polyneuropathy associated with the disease. For more information about ONPATTRO, visit ONPATTRO.com. ONPATTRO Important Safety Information Infusion-Related Reactions Infusion-related reactions (IRRs) have been observed in patients treated with ONPATTRO (patisiran). In a controlled clinical study, 19% of ONPATTRO-treated patients experienced IRRs, compared to 9% of placebo-treated patients. The most common symptoms of IRRs with ONPATTRO were flushing, back pain, nausea, abdominal pain, dyspnea, and headache. To reduce the risk of IRRs, patients should receive premedication with a corticosteroid, acetaminophen, and antihistamines (H1 and H2 blockers) at least 60 minutes prior to ONPATTRO infusion. Monitor patients during the infusion for signs and symptoms of IRRs. If an IRR occurs, consider slowing or interrupting the infusion and instituting medical management as clinically indicated. If the infusion is interrupted, consider resuming at a slower infusion rate only if symptoms have resolved. In the case of a serious or life-threatening IRR, the infusion should be discontinued and not resumed. Reduced Serum Vitamin A Levels and Recommended Supplementation ONPATTRO treatment leads to a decrease in serum vitamin A levels. Supplementation at the recommended daily allowance (RDA) of vitamin A is advised for patients taking ONPATTRO. Higher doses than the RDA should not be given to try to achieve normal serum vitamin A levels during treatment with ONPATTRO, as serum levels do not reflect the total vitamin A in the body. Patients should be referred to an ophthalmologist if they develop ocular symptoms suggestive of vitamin A deficiency (e.g. night blindness). Adverse Reactions The most common adverse reactions that occurred in patients treated with ONPATTRO were upper respiratory tract infections (29%) and infusion-related reactions (19%). For additional information about ONPATTRO, please see the full Prescribing Information. About GIVLAARI (givosiran) GIVLAARI is an RNAi therapeutic targeting aminolevulinic acid synthase 1 (ALAS1) approved in the United States and Brazil for the treatment of adults with acute hepatic porphyria (AHP). GIVLAARI is also approved in the European Union for the treatment of AHP in adults and adolescents aged 12 years and older. In the pivotal study, givosiran was shown to significantly reduce the rate of porphyria attacks that required hospitalizations, urgent healthcare visits or intravenous hemin administration at home compared to placebo. GIVLAARI is Alnylams first commercially available therapeutic based on its Enhanced Stabilization Chemistry ESC-GalNAc conjugate technology to increase potency and durability. GIVLAARI is administered via subcutaneous injection once monthly at a dose based on actual body weight and should be administered by a healthcare professional. GIVLAARI works by specifically reducing elevated levels of aminolevulinic acid synthase 1 (ALAS1) messenger RNA (mRNA), leading to reduction of toxins associated with attacks and other disease manifestations of AHP. For more information about GIVLAARI, visit GIVLAARI.com. GIVLAARI Important Safety Information Contraindications GIVLAARI is contraindicated in patients with known severe hypersensitivity to givosiran. Reactions have included anaphylaxis. Anaphylactic Reaction Anaphylaxis has occurred with GIVLAARI treatment (<1% of patients in clinical trials). Ensure that medical support is available to appropriately manage anaphylactic reactions when administering GIVLAARI. Monitor for signs and symptoms of anaphylaxis. If anaphylaxis occurs, immediately discontinue administration of GIVLAARI and institute appropriate medical treatment. Hepatic Toxicity Transaminase elevations (ALT) of at least 3 times the upper limit of normal (ULN) were observed in 15% of patients receiving GIVLAARI in the placebo-controlled trial. Transaminase elevations primarily occurred between 3 to 5 months following initiation of treatment. Measure liver function tests prior to initiating treatment with GIVLAARI, repeat every month during the first 6 months of treatment, and as clinically indicated thereafter. Interrupt or discontinue treatment with GIVLAARI for severe or clinically significant transaminase elevations. In patients who have dose interruption and subsequent improvement, reduce the dose to 1.25 mg/kg once monthly. The dose may be increased to the recommended dose of 2.5 mg/kg once monthly if there is no recurrence of severe or clinically significant transaminase elevations at the 1.25 mg/kg dose. Renal Toxicity Increases in serum creatinine levels and decreases in estimated glomerular filtration rate (eGFR) have been reported during treatment with GIVLAARI. In the placebo-controlled study, 15% of patients receiving GIVLAARI experienced a renally-related adverse reaction. The median increase in creatinine at Month 3 was 0.07 mg/dL. Monitor renal function during treatment with GIVLAARI as clinically indicated. Injection Site Reactions Injection site reactions were reported in 25% of patients receiving GIVLAARI in the placebo-controlled trial. Symptoms included erythema, pain, pruritus, rash, discoloration, or swelling around the injection site. One (2%) patient experienced a single, transient, recall reaction of erythema at a prior injection site with a subsequent dose administration. Drug Interactions Concomitant use of GIVLAARI increases the concentration of CYP1A2 or CYP2D6 substrates, which may increase adverse reactions of these substrates. Avoid concomitant use of GIVLAARI with CYP1A2 or CYP2D6 substrates for which minimal concentration changes may lead to serious or life-threatening toxicities. If concomitant use is unavoidable, decrease the CYP1A2 or CYP2D6 substrate dosage in accordance with approved product labeling. Adverse Reactions The most common adverse reactions that occurred in patients receiving GIVLAARI were nausea (27%) and injection site reactions (25%). For additional information about GIVLAARI, please see full Prescribing Information. About LNP Technology Alnylam has licenses to Arbutus Biopharma LNP intellectual property for use in RNAi therapeutic products using LNP technology. About RNAi RNAi (RNA interference) is a natural cellular process of gene silencing that represents one of the most promising and rapidly advancing frontiers in biology and drug development today. Its discovery has been heralded as a major scientific breakthrough that happens once every decade or so, and was recognized with the award of the 2006 Nobel Prize for Physiology or Medicine. By harnessing the natural biological process of RNAi occurring in our cells, a new class of medicines, known as RNAi therapeutics, is now a reality. Small interfering RNA (siRNA), the molecules that mediate RNAi and comprise Alnylam's RNAi therapeutic platform, function upstream of todays medicines by potently silencing messenger RNA (mRNA) the genetic precursors that encode for disease-causing or disease pathway proteins, thus preventing them from being made. This is a revolutionary approach with the potential to transform the care of patients with genetic and other diseases. About Alnylam Pharmaceuticals Alnylam (Nasdaq: ALNY) is leading the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare genetic, cardio-metabolic, hepatic infectious, and central nervous system (CNS)/ocular diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach for the treatment of a wide range of severe and debilitating diseases. Founded in 2002, Alnylam is delivering on a bold vision to turn scientific possibility into reality, with a robust RNAi therapeutics platform. Alnylams commercial RNAi therapeutic products are ONPATTRO (patisiran), approved in the U.S., EU, Canada, Japan, Brazil, and Switzerland, and GIVLAARI (givosiran), approved in the U.S, EU, and Brazil. Alnylam has a deep pipeline of investigational medicines, including six product candidates that are in late-stage development. Alnylam is executing on its Alnylam 2020 strategy of building a multi-product, commercial-stage biopharmaceutical company with a sustainable pipeline of RNAi-based medicines to address the needs of patients who have limited or inadequate treatment options. Alnylam is headquartered in Cambridge, MA. For more information about our people, science and pipeline, please visit www.alnylam.com and engage with us on Twitter at @Alnylam or on LinkedIn. Alnylam Forward Looking Statements Various statements in this release concerning Alnylams expectations, plans and prospects, including, without limitation, expectations regarding the direct or indirect effects on Alnylams business, activities and prospects as a result of the COVID-19 pandemic, or delays or interruptions resulting therefrom and the success of Alnylams mitigation efforts, Alnylam's views and plans with respect to the potential for RNAi therapeutics, including ONPATTRO, GIVLAARI, lumasiran, inclisiran, patisiran, vutrisiran, fitusiran, cemdisiran, ALN-AGT, ALN-HSD, ALN-COV and ALN-APP, its plans for additional global regulatory filings and the continuing product launches of ONPATTRO and GIVLAARI, expectations regarding reimbursement for ONPATTRO and GIVLAARI in various territories and the status of VBA agreements and confirmed access, the advancement of lumasiran and inclisiran through regulatory review and toward the market including the receipt of positive CHMP opinions for both drug candidates, the potential for a biannual dosing regimen option for vutrisiran, the achievement of additional pipeline milestones, including relating to ongoing clinical studies of vutrisiran, the expected timing for the presentation of interim results from the Phase 1 trial of ALN-AGT, the expected timing for filing a CTA for ALN-APP and the revised expectations regarding the filing of an IND for ALN-COV, the initiation of a Phase 1 clinical study of cemdisiran in combination with pozelimab by Regeneron, its expectations relating to continued ONPATTRO and GIVLAARI revenue growth and the further revised expected range of ONPATTRO net product revenues for 2020, the expected range for net revenues from collaborations for 2020, the revised expected range of 2020 aggregate annual non-GAAP and R&D and SG&A expenses and further revised expected range of 2020 aggregate annual GAAP R&D and SG&A expenses, Alnylams belief that the funding provided by Blackstone should enable Alnylam to achieve a self-sustainable profile without the need for future equity financing, and expectations regarding Alnylams ability to exceed its Alnylam 2020 strategic plan announced in 2015 for the advancement and commercialization of RNAi therapeutics, constitute forward-looking statements for the purposes of the safe harbor provisions under The Private Securities Litigation Reform Act of 1995. Actual results and future plans may differ materially from those indicated by these forward-looking statements as a result of various important risks, uncertainties and other factors, including, without limitation: the direct or indirect impact of the COVID-19 global pandemic or any future pandemic, such as the scope and duration of the outbreak, government actions and restrictive measures implemented in response, material delays in diagnoses of rare diseases, initiation or continuation of treatment for diseases addressed by Alnylam products, or in patient enrollment in clinical trials, potential supply chain disruptions, and other potential impacts to Alnylams business, the effectiveness or timeliness of steps taken by Alnylam to mitigate the impact of the pandemic, and Alnylams ability to execute business continuity plans to address disruptions caused by the COVID-19 or any future pandemic; Alnylam's ability to discover and develop novel drug candidates and delivery approaches and successfully demonstrate the efficacy and safety of its product candidates, including vutrisiran, ALN-AGT, ALN-HSD, ALN-APP and ALN-COV; the pre-clinical and clinical results for its product candidates, which may not be replicated or continue to occur in other subjects or in additional studies or otherwise support further development of product candidates for a specified indication or at all; actions or advice of regulatory agencies, which may affect the design, initiation, timing, continuation and/or progress of clinical trials or result in the need for additional pre-clinical and/or clinical testing; delays, interruptions or failures in the manufacture and supply of its product candidates or its marketed products, including ONPATTRO, GIVLAARI, inclisiran, lumasiran and vutrisiran; obtaining, maintaining and protecting intellectual property; intellectual property matters including potential patent litigation relating to its platform, products or product candidates; obtaining regulatory approval for its product candidates, including lumasiran and inclisiran, and maintaining regulatory approval and obtaining pricing and reimbursement for its products, including ONPATTRO and GIVLAARI; successfully launching, marketing and selling its approved products globally, including ONPATTRO and GIVLAARI and achieving net product revenues for ONPATTRO within its further revised expected range during 2020; Alnylams ability to successfully expand the indication for ONPATTRO in the future; competition from others using technology similar to Alnylam's and others developing products for similar uses; Alnylam's ability to manage its growth and operating expenses within the reduced ranges of guidance provided by Alnylam through the implementation of further discipline in operations to moderate spend and its ability to achieve a self-sustainable financial profile in the future without the need for future equity financing; Alnylams ability to establish and maintain strategic business alliances and new business initiatives; Alnylam's dependence on third parties, including Regeneron, for development, manufacture and distribution of certain products, including eye and CNS products and ALN-APP, and Vir for the development of ALN-COV and other potential RNAi therapeutics targeting SARS-CoV-2 and host factors for SARS-CoV-2; the outcome of litigation; the risk of government investigations; and unexpected expenditures, as well as those risks more fully discussed in the Risk Factors filed with Alnylam's most recent Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (SEC) and in other filings that Alnylam makes with the SEC. In addition, any forward-looking statements represent Alnylam's views only as of today and should not be relied upon as representing its views as of any subsequent date. Alnylam explicitly disclaims any obligation, except to the extent required by law, to update any forward-looking statements. This release discusses investigational RNAi therapeutics and uses of previously approved RNAi therapeutics in development and is not intended to convey conclusions about efficacy or safety as to those investigational therapeutics or uses. There is no guarantee that any investigational therapeutics or expanded uses of commercial products will successfully complete clinical development or gain health authority approval. ALNYLAM PHARMACEUTICALS, INC. CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (In thousands, except per share amounts) (Unaudited) Three Months Ended Nine Months Ended September 30, 2020 September 30, 2019 September 30, 2020 September 30, 2019 Statements of Operations Revenues: Net product revenues $ 99,206 $ 46,066 $ 248,677 $ 110,588 Net revenues from collaborations 26,647 23,995 80,614 37,481 Total revenues 125,853 70,061 329,291 148,069 Operating costs and expenses: Cost of goods sold 21,797 5,213 55,028 12,886 Research and development 161,783 160,796 486,350 453,813 Selling, general and administrative 167,472 120,351 422,129 322,728 Total operating costs and expenses 351,052 286,360 963,507 789,427 Loss from operations (225,199) (216,299) (634,216) (641,358) Other (expense) income: Interest expense (28,731) (55,979) Interest income 2,072 9,889 10,717 26,195 Other (expense) income (594) (2,519) 67,477 (2,929) Change in fair value of liability obligation 9,422 Total other (expense) income (27,253) 7,370 22,215 32,688 Loss before income taxes (252,452) (208,929) (612,001) (608,670) (Provision) benefit for income taxes (839) 394 (2,740) (1,261) Net loss $ (253,291) $ (208,535) $ (614,741) $ (609,931) Net loss per common share - basic and diluted $ (2.18) $ (1.92) $ (5.37) $ (5.63) Weighted-average common shares used to compute basic and diluted net loss per common share 115,986 108,701 114,554 108,427 ALNYLAM PHARMACEUTICALS, INC. RECONCILIATION OF SELECTED GAAP MEASURES TO NON-GAAP MEASURES (In thousands, except per share amounts) Three Months Ended September 30, 2020 September 30, 2019 Reconciliation of GAAP to Non-GAAP research and development: GAAP Research and development $ 161,783 $ 160,796 Less: Stock-based compensation expenses (13,703) (22,737) Non-GAAP Research and development $ 148,080 $ 138,059 Reconciliation of GAAP to Non-GAAP selling, general and administrative: GAAP Selling, general and administrative $ 167,472 $ 120,351 Less: Stock-based compensation expenses (23,561) (23,272) Less: Costs associated with the strategic financing collaboration (763) Less: Loss on contractual settlement (650) Less: Change in estimate of contingent liabilities (28,000) Non-GAAP Selling, general and administrative $ 114,498 $ 97,079 Reconciliation of GAAP to Non-GAAP operating loss: GAAP operating loss $ (225,199) $ (216,299) Add: Stock-based compensation expenses 37,264 46,009 Add: Costs associated with the strategic financing collaboration 763 Add: Loss on contractual settlement 650 Add: Change in estimate of contingent liabilities 28,000 Non-GAAP operating loss $ (158,522) $ (170,290) Reconciliation of GAAP to Non-GAAP net loss: GAAP net loss $ (253,291) $ (208,535) Add: Stock-based compensation expenses 37,264 46,009 Add: Costs associated with the strategic financing collaboration 763 Add: Loss on contractual settlement 650 Add: Change in estimate of contingent liabilities 28,000 Add: Unrealized loss on marketable equity securities 3,017 Non-GAAP net loss $ (183,597) $ (162,526) Reconciliation of GAAP to Non-GAAP net loss per common share-basic and diluted: GAAP net loss per common share - basic and diluted $ (2.18) $ (1.92) Add: Stock-based compensation expenses 0.32 0.42 Add: Costs associated with the strategic financing collaboration 0.01 Add: Loss on contractual settlement 0.01 Add: Change in estimate of contingent liabilities 0.24 Add: Unrealized gain on marketable equity securities 0.02 Non-GAAP net loss per common share - basic and diluted $ (1.58) $ (1.50) Please note that the figures presented above may not sum exactly due to rounding ALNYLAM PHARMACEUTICALS, INC. CONDENSED CONSOLIDATED BALANCE SHEETS (In thousands, except share amounts) (Unaudited) September 30, 2020 December 31, 2019 Cash, cash equivalents and marketable securities $ 1,833,876 $ 1,536,162 Restricted investments 24,725 14,825 Accounts receivable, net 79,118 43,011 Inventory 84,040 56,348 Prepaid expenses and other assets 95,600 98,412 Property, plant and equipment, net 444,690 425,179 Operating lease right-of-use lease assets 245,234 221,197 Receivable related to the sale of future royalties 500,000 Total assets $ 3,307,283 $ 2,395,134 Accounts payable, accrued expenses and other liabilities $ 339,473 $ 256,415 Total deferred revenue 380,309 396,204 Operating lease liability 329,454 303,823 Liability related to the sale of future royalties 1,043,024 Total stockholders equity (116.1 million shares issued and outstanding at September 30, 2020; 112.2 million shares issued and outstanding at December 31, 2019) 1,215,023 1,438,692 Total liabilities and stockholders' equity $ 3,307,283 $ 2,395,134 This selected financial information should be read in conjunction with the consolidated financial statements and notes thereto included in Alnylams Annual Report on Form 10-K which includes the audited financial statements for the year ended December 31, 2019.

Answer: Alnylam Pharmaceuticals Reports Third Quarter 2020 Financial Results and Highlights Recent Period Activity Achieved Third Quarter 2020 ONPATTRO Global Net Product Revenue of $82.5 Million, Including Over 20% Quarterly U.S. Growth, with More Than 1,150 Patients on Commercial Product Worldwide Achieved Third Quarter 2020 GIVLAARI Global Net Product Revenue of $16.7 Million, with More Than 150 Patients on Commercial Product Worldwide Received Positive Opinions for OXLUMO (lumasiran) and LEQVIO (inclisiran) from the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA), Positioning the Company for Potentially Four Approved RNAi Therapeutic Medicines by Year-End 2020 Increased 2020 Guidance Range for ONPATTRO Revenue from $280-$300 Million to $295-$310 Million