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TEL AVIV--(BUSINESS WIRE)--The NextDREAM Consortium announces the publication in Nature Medicine of a multicenter, multinational, six-month study assessing the efficacy and safety of an automated AI-based decision-support system, the DreaMed Advisor, compared with physician-guided recommendations in a non-inferiority randomized controlled trial. The findings of the study concluded that glucose control was statistically similar after 6 months of frequent insulin pump titration, at 3-week intervals, either by using the DreaMed Advisor or by physicians with diabetes expertise, as measured by percentage of time glucose levels were in range (70-180 mg/dL), in the very low range (below 54 mg/dL), and by reduction in HbA1c levels from baseline. No adverse severe events were reported in the arm that used the DreaMed Advisor technology. With more than a million people in the United States with Type I diabetes, a solution to ease their ability to conveniently manage their condition and frequently change their insulin treatment plan has been long-sought after, but not at the expense of safety and reliability. The increasing prevalence of diabetes,1,2 mounting shortage of specialized endocrinologists,3 and current COVID-19 reality that limits access to face-to-face visits with physicians, have raised the stakes even higher. Decision-support systems with proven clinical efficacy have the potential to deliver this assistance and elevate the quality of diabetes care by creating a virtual expert diabetes clinic that facilitates more frequent insulin adjustments in a cost-effective manner. "This Nature Medicine publication is an important first step toward the implementation of AI-based decision-support technology as part of the standard way we manage the insulin therapy of people with diabetes," says Prof. Moshe Phillip, the Director of the Institute for Endocrinology and Diabetes at Schneider Children's MC in Israel & the nextDREAM Consortium Coordinator. "With the Advisor, healthcare providers will be able to use an easy and clinically effective decision-support tool that will give them more time to interact with their patients, while making regular clinics visits to the doctor more efficient. For people with diabetes, it will ultimately mean 24/7 access to personalized medical advice, a kind of expert diabetes physician in your pocket, that will bring people with type 1 diabetes greater balance and an improved quality of life." Managing type 1 diabetes can be very challenging for young people and their families, as well as healthcare providers, given the need to assess glucose levels and insulin requirements on a frequent basis in order to optimize diabetes control, says Lori Laffel MD, MPH, Chief of the Pediatric, Adolescent and Young Adult Section at the Joslin Diabetes Center and Professor of Pediatrics at Harvard Medical School in Boston, MA. This study of 108 young people with type 1 diabetes, aged 10-21 years, indicates that frequent insulin adjustments transmitted remotely using an automated AI system can be as effective as expert physician dose adjustments, saving the healthcare provider time. Such an approach can be especially helpful during the current pandemic and can facilitate more timely insulin dose adjustments aimed at improving glycemic control. Mounting evidence proves maintaining glucose levels within the target range considerably improves long-term outcomes in people with type 1 diabetes. The Nature Medicine publication demonstrates the DreaMed Advisor can be as safe and efficient as physicians with expertise in diabetes, providing a new AI-based solution to all health-care providers, says Prof. Tadej Battelino, MD, PhD, Head of the Department of Endocrinology, Diabetes and Metabolism at the University Childrens Hospital, University Medical Center Ljubljana, and Chair of Pediatrics, Faculty of Medicine, University of Ljubljana. Using the DreaMed Advisor in routine diabetes practice can increase the level of diabetes care to a higher, more homogeneous level, and save time and resources, also in times when remote virtual diabetes management may be the safest solution. Key Data Highlights Glycemic control over six months: Find the clinical study on Nature Medicine here: https://www.nature.com/articles/s41591-020-1045-7 The NextDREAM Consortium Group Participating clinical sites and study team members: University of Florida College of Medicine in Gainesville, FL: Desmond Schatz MD, Michael Haller MD, Paul Hiers MD, Laura Jacobsen MD, Madison Smith PhD RN, Anastasia ONeill ARNP, PhD, Jennifer Hosford MPH, Alexis Perry. Joslin Diabetes Center, Harvard Medical School, Boston, MA: Lori Laffel MD, MPH, Michelle Katz MD MPH, Elvira Isganaitis MD MPH, Sanjeev Mehta MD MPH, Heidi Quinn RD CDE, Nisha Naik BA, Zijing Guo MPH, Lisa Volkening MA. Barbara Davis Center for Childhood Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO: Robert Slover MD, Gregory Forlenza MD, R. Paul Wadwa, MD, G. Todd Alonso, MD, Laurel Messer RN, PhD, CDE, Lindsey Towers BS, Katie Thivener BS, Cari Berget RN, MPH, CDE, Samantha Lange RN, BSN, CDE, Emily Jost RD, MS, CDE , Maria Rossick-Solis. Yale University School of Medicine in New Haven, CT: Stuart A. Weinzimer MD, Eda Cengiz MD MHS, Jennifer Sherr MD PhD, Kathryn Gibbons MD, Lori Carria MS, Melinda Zgorski BSN. Diabetes-Zentrum fr Kinder und Jugendliche in Hannover, Germany: Thomas Danne MD, Torben Biester MD, Olga Kordonouri MD, Thekla von dem Berge MD, Sarah Biester RN, CDE, Kerstin Remus RN, CDE. University Children's Hospital in Ljubljana, Slovenia: Tadej Battelino MD, PhD, Klemen Dovc MD, PhD, Natasa Bratina MD, PhD, Darja Smigoc Schweiger MD, PhD, Brigita Mali B.Admin, Ana Gianini RNS, CDE, Urska Sever RNS, CDE, Barbara Murn Berkopec RNS, CDE. Schneider Children's Medical Center of Israel in Petah Tikva, Israel: Moshe Phillip MD, Revital Nimri MD, Shlomit Shalitin MD, Rachel Bello MD, Michal Nevo Shenker MD, Naama Fisch Shvalb MD, Galit Shiovitch Mantzuri R.N M.N, Orit Choresh B.A. R.N, Irit Drutz B.A. R.N, Yehiel Nava B.S.N, R. N, Alona Hamou M.Sc, Orna Hermon B.A, Rachel Naveh, Llb. 1https://www.idf.org/e-library/epidemiology-research/diabetes-atlas/134-idf-diabetes-atlas-8th-edition.html 2Patterson CC, Harjutsalo V, Rosenbauer J, et al. Trends and cyclical variation in the incidence of childhood type 1 diabetes in 26 European centres in the 25 year period 1989-2013: a multicentre prospective registration study. Diabetologia. 2019;62(3):408-417 3Vigersky RA, Fish L, Hogan P, et al. The clinical endocrinology workforce: current status and future projections of supply and demand. J Clin Endocrinol Metab. 2014;99(9):3112-3121

Answer: Nature Medicine Publishes Results Reporting Equal Clinical Outcome When Using The DreaMed Advisor Compared With Physicians From Specialized Academic Diabetes Centers The diabetes research carried out by the NextDREAM Consortium group is a major international study to assess AI technology, published in Nature Medicine, marking an important milestone in the progress of remote diabetes solutions