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INDIANAPOLIS, April 16, 2020 /PRNewswire/ --Non-branded versions of Humalog Mix75/25 KwikPen (insulin lispro protamine and insulin lispro injectable suspension, 100 units/mL) and Humalog Junior KwikPen (insulin lispro injection, 100 units/mL) are now available for order by U.S. pharmacies adding to the broad suite of affordability options offered by Eli Lilly and Company (NYSE: LLY). These non-branded insulin options are identical to the branded versions, with different packaging and a 50 percent lower list price of $265.20 for a package of five KwikPens. Availability follows the launch of the Lilly Insulin Value Program, which reduces the monthly prescription out-of-pocket cost for most Lilly insulins to $35 for people with commercial insurance and those with no insurance. Both of these non-branded options are eligible for the $35 co-pay program, which can be obtained by calling the Lilly Diabetes Solution Center at (833) 808-1234 (8 am to 8 pm ET, Monday through Friday). Lilly also continues to offer Insulin Lispro Injection (100 units/mL), the non-branded version of Humalog U-100, at a 50 percent lower list price of$137.35per vial and$265.20for a package of five KwikPens. Insulin Lispro Injection was made available in May 2019. Now, approximately 1 out of every 6 prescriptions filled for Humalog U-100 is for this non-branded option. In March 2020, more than 128,000 prescriptions were filled for Insulin Lispro Injection. All of Lilly's non-branded insulins are distributed by all major U.S. wholesalers and can be ordered by any pharmacy. Insulin Lispro Injection is included in Lilly's $35 co-pay program for the uninsured and people with employer or other commercial insurance plans. "Out-of-pocket costs for insulin vary significantly depending on a person's insurance coverage design. It's important that we fill gaps in the healthcare system, including for people who use Medicare Part D and are unable to use the savings cards in our program," said Mike Mason, president, Lilly Diabetes. The non-branded version of Humalog Mix75/25 will be known as Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25KwikPen(100 units/mL). The non-branded version of Humalog Junior KwikPen will be known as Insulin Lispro Injection Junior KwikPen(100 units/mL). All our non-branded insulin options are identical to the branded versions, with different packaging and a 50 percent lower list price, and pharmacists may substitute them at the pharmacy counter. Given that out-of-pocket costs at the pharmacy can vary greatly due to insurance plan designs and co-pays, people should ask their pharmacist whether these options reduce their out-of-pocket cost. Anyone who uses a Lilly insulin can call the Lilly Diabetes Solution Center at (833) 808-1234 (8 am to 8 pm ET Monday through Friday) to see whether one of the non-branded insulins, the Lilly Insulin Value Program, or another affordability option is the best financial choice for them. Staffed by health care professionals, the Solution Center can provide significant savings on Lilly insulins in multiple ways,including out-of-pocket discounts on what people with commercial plans and the uninsured pay at the pharmacy and information about how to access donated insulin at nearly 200 free clinics across the country. Lilly's solutions help up to 20,000 people each month reduce their out-of-pocket costs for insulin. Terms, conditions, and limitations apply to the co-pay cards. Not available to those patients with government insurance such as Medicaid, Medicare, Medicare Part D, TRICARE/CHAMPUS, Medigap, DoD, or any State Patient or Pharmaceutical Assistance Program. PURPOSE and SAFETY SUMMARY Important Facts About Humalog (HU-ma-log) and Insulin Lispro Injection Humalog is also known as insulin lispro injection. Humalog and Insulin Lispro Injection are fast-acting insulins. They are used to control high blood sugar in adults and children with diabetes. They are available only with a prescription. Humalog comes in two strengths: U-100 (100 units per milliliter) and U-200 (200 units per milliliter). The Humalog U-200 prefilled pen contains 2 times as much insulin per 1 milliliter as standard (U-100) insulin. The dose window on the pen shows your insulin dose. It is not known if Humalog or Insulin Lispro Injection are safe and effective for children with type 2 diabetes or for children younger than 3 years of age with type 1 diabetes. There were no studies done with these insulins in these groups of children. If your doctor decides to give your child one of these insulins, he or she may give you special instructions. Important Facts about Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 Humalog Mix50/50 and Humalog Mix75/25 are known as insulin lispro protamine and insulin lispro injectable suspension. Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 are mixed U-100 insulins. This means they contain a mix of fast-acting and intermediate-acting insulins. They are used to control high blood sugar in people with diabetes. They are available only with a prescription. It is not known if Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 are safe and effective for children younger than 18 years of age. There were no studies done with these insulins in children younger than 18. If your doctor decides to give your child one of these insulins, he or she may give you special instructions. All Humalog and Insulin Lispro Injection products contain insulin lispro. Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 contain insulin lispro protamine mixed with insulin lispro. Warnings Do not take Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 if you have: symptoms of low blood sugar (hypoglycemia) an allergy to insulin lispro products or any of their ingredients. Do not reuse needles or share your insulin injection supplies with other people. This includes your: prefilled pen for use by a single patient cartridges reusable pen that works with Lilly 3mL cartridges needles syringes You or the other person can get a serious infection. This can happen even if you change the needle. Do notchange the type of insulin you take or your dose, unless your doctor tells you to. This could cause low or high blood sugar, which could be serious. Do notuse a syringe to remove Humalog from your prefilled pen. This can cause you to take too much insulin. Taking too much insulin can lead to severe low blood sugar. This may result in seizures or death. Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 may cause serious side effects. Some of these can lead to death.The possible serious side effects are: Low blood sugar.This can cause: dizziness or light-headedness sweating confusion headache blurred vision slurred speech shakiness fast heartbeat anxiety irritability mood change hunger If you are at risk of having severely low blood sugar, your doctor may prescribe a glucagon emergency kit. These are used when your blood sugar becomes too low and you are unable to take sugar by mouth. Glucagon helps your body release sugar into your bloodstream. Severe allergic reaction. Get emergency help right away if you have: a rash over your whole body trouble breathing a fast heartbeat sweating a faint feeling shortness of breath extreme drowsiness dizziness confusion swelling of your face, tongue, or throat Low potassium in your blood.This can lead to severe breathing problems, irregular heartbeat, and death. Heart failure.Taking diabetes pills called thiazolidinediones (thIE-uh-zOH-li-dEEn-dIE-OHns), or "TZDs," with insulin lispro products may cause heart failure in some people. This includes people who do not have any heart problems. If you have heart failure, it may get worse if you take TZDs with these insulin lispro products. Tell your doctor if you have any new symptoms of heart failure, or if they get worse. Some symptoms of heart failure include: shortness of breath, swelling of ankles and feet, and sudden weight gain. Your doctor may need to change or stop treatment with TZDs and your insulin lispro product. High blood sugar and ketoacidosis.You can have these serious problems when your insulin pump or infusion set stops working. They can also happen if your insulin is no longer effective. For these reasons, always keep extra insulin injection supplies with you. Common side effects The most common side effects of Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25are: low blood sugar allergic reactions reactions where you have injected insulin changes in fat tissue where you have injected insulin swelling of your hands or feet weight gain itching rash These are not all of the possible side effects. Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch. Before using Talk with your doctor about low blood sugar and how to manage it. Also tell your doctor: about all of the medicines you take, including over-the-counter medicines, vitamins, and herbal supplements. about any other prescription medicines you take, especially ones called TZDs. about all of your medical conditions, including if you have heart failure or other heart, liver, or kidney problems. if you are pregnant, breastfeeding, or plan to become pregnant or breastfeed. How to take Read the Instructions for Use that come with your Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25. Be sure to take your insulin lispro product and check your blood sugar levels exactly as your doctor tells you to. Your doctor may tell you to change your dose because of illness, increased stress, or changes in your weight, diet, or physical activity level. He or she may also tell you to change the amount or time of your dose because of other medicines or different types of insulin you take. Before injecting your insulin lispro product You can inject your insulin dose yourself, or you can have a trained caregiver inject it for you. Make sure you or your caregiver: Check the insulin label before each injection. This will help you make sure that you are taking the correct insulin. Use a new needle for each injection. You can get a serious infection or the wrong dose of insulin if you re-use needles. Change (rotate) where you inject your insulin with each dose. This can reduce your chance of getting pits, lumps, or thickened skin where you inject your insulin. Do not inject your insulin into the exact same spot or where the skin has pits or lumps. Avoid injecting into thickened, tender, bruised, scaly, hard, scarred, or damaged skin. When you are ready to inject If you are taking Humalog or Insulin Lispro Injection, inject it under your skin within 15 minutes before or right after you eat a meal. If you are taking Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25, inject it under your skin within 15 minutes before you eat a meal. Staying safe while taking your insulin lispro product To stay safe while taking your insulin, be sure to never inject Humalog U-200, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 in your vein, muscle, or with an insulin pump. Also be sure not to: mix Humalog U-200, Humalog Mix50/50, Humalog Mix75/25, or Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 with other insulins or liquids. drive or use heavy machinery until you know how your insulin lispro product affects you. drink alcohol or use other medicines that contain alcohol when taking your insulin lispro product. Learn more For more information, call 1-800-545-5979 or go to www.humalog.com or www.lillyinsulinlispro.com. This summary provides basic information about Humalog, Insulin Lispro Injection, Humalog Mix50/50, Humalog Mix75/25, and Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25. It does not include all information known about these medicines. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your doctor. Be sure to talk to your doctor or other health care provider about your insulin lispro product and how to take it. Your doctor is the best person to help you decide if these medicines are right for you. HI BOI SP U100 75/25 CON BS 10JAN2020 For additional information, talk to your healthcare providers and please click to access HumalogFull Prescribing Information, Humalog U-100 Patient Information, Humalog U-200 Patient Information, Humalog Mix75/25Full Prescribing Information and Patient Information, Humalog Mix50/50 Full Prescribing Information and Patient Information, Insulin Lispro InjectionFull Prescribing Information,and Patient Information, Insulin Lispro Protamine and Insulin Lispro Injectable Suspension Mix75/25 Full Prescribing Information, and Patient Information. Please see Instructions for Use included with the product. TRICARE is a registered trademark owned by the U.S. Department of Defense. All other trademarks and registered trademarks are the property of Eli Lilly and Company, its subsidiaries, or affiliates. About Diabetes Approximately 34 million Americans1(just over 1 in 10)and an estimated 463 million adults worldwide2have diabetes. Type 2 diabetes is the most common type internationally, accounting for an estimated 90 to 95 percent of all diabetes cases in the United States alone1.Diabetes is a chronic disease that occurs when the body does not properly produce or use the hormone insulin. About Lilly Diabetes Lilly has been a global leader in diabetes care since 1923, when we introduced the world's first commercial insulin. Today we are building upon this heritage by working to meet the diverse needs of people with diabetes and those who care for them. Through research, collaboration and quality manufacturing we strive to make life better for people affected by diabetes and related conditions. We work to deliver breakthrough outcomes through innovative solutionsfrom medicines and technologies to support programs and more. For the latest updates, visit lillydiabetes.com or follow us on Twitter: @LillyDiabetes and Facebook: LillyDiabetesUS. About Eli Lilly and Company Lilly is a global healthcare leader that unites caring with discovery to create medicines that make life better for people around the world. We were founded more than a century ago by a man committed to creating high-quality medicines that meet real needs, and today we remain true to that mission in all our work. Across the globe, Lilly employees work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to communities through philanthropy and volunteerism. To learn more about Lilly, please visit us at lilly.com and lilly.com/newsroom. P-LLY This press release contains forward-looking statements (as that term is defined in the Private Securities Litigation Reform Act of 1995) about Humalog Mix75/25 (insulin lispro protamine and insulin lispro injectable suspension 100 units/mL), Humalog Junior KwikPen (insulin lispro injection 100 units/mL), and Insulin Lispro Injection as treatment for patients with diabetes and reflects Lilly's current belief. However, as with any pharmaceutical product, there are substantial risks and uncertainties in the process of development and commercialization. Among other things, there can be no guarantee that Humalog Mix75/25, Humalog Junior KwikPen or Insulin Lispro Injection will be commercially successful or that we can provide an adequate supply of these products in all circumstances. For further discussion of these and other risks and uncertainties, see Lilly's most recent Form 10-K and Form 10-Q filings with the United States Securities and Exchange Commission. Except as required by law, Lilly undertakes no duty to update forward-looking statements to reflect events after the date of this release. Refer to: Dani Barnhizer; [emailprotected]; 317.607.6119 (Lilly Diabetes Communications) Kevin Hern; [emailprotected]; 317.277.1838 (Investor Relations) 1Centers for Disease Control and Prevention. National Diabetes Statistics Report, 2020. Atlanta, GA: Centers for Disease Control and Prevention, U.S. Dept. of Health and Human Services; 2020. 2International Diabetes Federation. IDF Diabetes Atlas, 9thedn. Brussels, Belgium: International Diabetes Federation, 2019. Available at:http://diabetesatlas.org. PP-SP-US-0210 4/2020Lilly USA, LLC 2020. All rights reserved. SOURCE Eli Lilly and Company Related Links http://www.lilly.com

Answer: Lower-priced versions of Humalog Mix75/25 KwikPen and Humalog Junior KwikPen now available Non-branded insulins have a 50 percent lower list price than branded versions