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DUBLIN, Jan. 14, 2021 /PRNewswire/ -- The "Crohn's Disease Forecast and Market Analysis to 2027" report has been added to ResearchAndMarkets.com's offering. As specialty products, therapies for Crohn's disease (CD) can be expensive, and formulary positioning is paramount to product uptake. Payers are settled in vital contracts that lead them to prioritize broad immunology drugs Humira and Remicade. This has posed a high barrier to newer entrants to the market, which cannot compete in volume and rebates. Biosimilar and generic competition will further undermine the likely premium pricing of newer drugs and pipeline products. Over the next decade, all key marketed brands for CD will have faced patent expiry. Thus far, the European market has taken the brunt of biosimilar erosion, with earlier launches and more acceptance compared to other countries. In the US, biosimilars will face challenges in usurping branded anti-TNFs, with adalimumab biosimilars not expected until 2023, substantial originator rebates, and exclusive contracting with payers. Over time, biosimilar penetration is anticipated to gain more momentum as international real-world evidence accumulates and long-term data support biosimilar efficacy and safety. This should allow physicians and patients to grow their confidence and familiarity with biosimilars and encourage uptake. Nevertheless, the CD market is projected to expand, propelled by a growing patient caseload and the introduction of pipeline products. The publisher estimates that in 2018, there were 6.1 million prevalent cases of CD worldwide, and forecasts that number to increase to 6.5 million prevalent cases by 2027. The entry of novel drug classes will drive growth of the CD market, despite facing cost-related barriers to uptake. The pipeline holds distinct prospects that aim to treat non-responders, including the oral JAK inhibitors Jyseleca and Rinvoq. These will be welcomed for their distinguished mechanisms of action, and their oral formulation will further offer unprecedented convenience in the CD treatment algorithm. Targeting global markets broadens their commercial potential as they are being investigated across the US, Japan, and Europe. Advantageously, over the forecast period, Rinvoq and Jyseleca will not encounter the increasing biosimilar competition that will directly erode sales of already marketed drugs. On the other hand, newer premium-priced entrants will likely be relegated to later lines of therapy after cheaper conventional drugs and biosimilars. Significant unmet needs include targeting inadequate responders to biologic and conventional therapies, as well as underserved patients with fistulas. In terms of clinical trials, active comparators and the endoscopic endpoints should be prioritized as there is a stark absence of head-to-head data and the field is moving towards endoscopic treatment goals. Additionally, new mechanisms of action and convenient oral therapies that are safe and effective are desirable. Pricing will be critical to secure favorable positioning in formularies and maximize commercial opportunities. Key Topics Covered: OVERVIEW Latest key takeaways DISEASE BACKGROUND Definition Symptoms Patient segmentation TREATMENT ACG treatment guidelines ECCO treatment guidelines NICE treatment guidelines EPIDEMIOLOGY Prevalence methodology MARKETED DRUGSPIPELINE DRUGSKEY REGULATORY EVENTS Japan Nods Include Global Firsts For Duvroq, Vafseo And First Local Biosimilar Humira EU Approves Takeda's Injectable Entyvio for IBD Part B Drugs At Home: Medicare Policy Responds To COVID-Driven Access Concerns Alberta Is Second Canadian Province To Switch To Biosimilars CHMP Positive On Pfizer's Adalimumab Keeping Track Of Approvals: Two Novel Drugs (Givlaari And Xcopri), A Project Orbis Collaboration (Calquence) And Another Humira Biosimilar PROBABILITY OF SUCCESSLICENSING AND ASSET ACQUISITION DEALS Cytocom Goes Public Via Merger With Cleveland BioLabs UCB, Ferring Will Co-Promote Cimzia Syringe For Crohn's In US Gilead Moves Into Microbiome In Deal With Second Genome Beximco And Mylan Strike Biosimilars Deal Asia Deal Watch: Mundipharma Will Sell Samsung Bioepis' Biosimilars In Taiwan, Hong Kong AZ Gets IBD Drug Back From Allergan CLINICAL TRIAL LANDSCAPE Sponsors by status Sponsors by phase Recent events DRUG ASSESSMENT MODEL Biologic DMARDs Non-biologic DMARDs Stem cell therapy Antibiotics MARKET DYNAMICSFUTURE TRENDS Despite formulary constraints, novel pipeline drugs will expand the market Biosimilar erosion of key brands will intensify over the next 10 years CONSENSUS FORECASTSRECENT EVENTS AND ANALYST OPINION Tremfya for Crohn's Disease (October 12, 2020) Stelara for Crohn's Disease (February 13, 2020) PRV-6527 for Crohn's Disease (October 22, 2019) Inflectra for Crohn's Disease (September 19, 2019) Multiple Drugs for Crohn's Disease (June 25, 2019) Mirikizumab for Crohn's Disease (May 21, 2019) KEY UPCOMING EVENTSUNMET NEEDS There is critical unmet need for predictive biomarkers Biologics with rapid onset and sustained remission Novel oral treatments Diverse head-to-head trials and trials for fistulas BIBLIOGRAPHY Prescription information APPENDIXFor more information about this report visit https://www.researchandmarkets.com/r/wtgqa3 Research and Markets also offers Custom Research services providing focused, comprehensive and tailored research. 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Answer: Global Crohn's Disease Market Analysis & Forecasts, 2020-2027: Treatment, Epidemiology, Pipeline, Key Regulatory Events, Licensing & Asset Acquisitions, Trends and Upcoming Events