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DUBLIN, July 29, 2020 /PRNewswire/ --Alkermes plc (Nasdaq: ALKS) today reported financial results for the second quarter of 2020 and provided updated financial expectations for full-year 2020. The company had previously withdrawn its 2020 financial expectations due to uncertainties regarding the impact of the COVID-19 pandemic on its business. "During the second quarter, we adapted in response to the changing conditions in a complex environment. As we enter the second half of 2020, we are focused on three strategic imperatives. The first is commercial execution, as we drive to maximize the opportunities for ARISTADAand VIVITROL and prepare for the potential launch of ALKS 3831. The second is aggressive development of our pipeline programs, focusing on high-value opportunities that we believe have the potential to address patient needs and drive significant value in the near- and long-term. ALKS 4230, our lead oncology candidate, is the most prominent of these opportunities. The third is efficient management of our operating structure, with a focus on rigorous expense management and careful prioritization of our investments," said Richard Pops, Chief Executive Officerof Alkermes. "We distinguish ourselves from other biopharmaceutical companies through our efforts in serious mental illness and addiction chronic, highly prevalent conditions that affect millions of people and represent some of the most challenging public health issues of our time. We have built our organization with purpose and invested in specialized commercial capabilities to navigate fragmented treatment systems as we help address the complex challenges that patients with these diseases face," continued Mr. Pops. "As the nation's response to COVID-19 continues, it is critical that we work to mitigate the pandemic's secondary impacts related to social isolation, economic hardship and anxiety. For many patients struggling with serious mental illness and addiction, the current environment has amplifiedthe barriers to treatment that Alkermes has worked for many years to address. We believe it is our responsibility to help ensure that the treatment system continues to function for these patients." Quarter Ended June 30, 2020 Financial Highlights Total revenues for the quarter were $247.5 million, compared to $279.9 million for the same period in the prior year. Net loss according to generally accepted accounting principles in the U.S. (GAAP) was $29.4 million for the quarter, or a GAAP net loss per share of $0.19. This compared to GAAP net loss of $42.0 million, or a GAAP net loss per share of $0.27, for the same period in the prior year. Non-GAAP net income was $8.9 million for the quarter, or a non-GAAP basic and diluted earnings per share of $0.06. This compared to non-GAAP net income of $13.7 million, or a non-GAAP basic and diluted earnings per share of $0.09, for the same period in the prior year. Quarter Ended June 30, 2020 Financial Results Revenues Net sales of proprietary products were $130.4 million, compared to $136.6 million for the same period in the prior year. Net sales of VIVITROL were $71.6 million, compared to $88.2 million for the same period in the prior year, representing a decrease of approximately 19%, driven primarily by a decline in new patient starts and more restricted access to healthcare providers that resulted from COVID-19-related disruptions. Net sales of ARISTADAiwere $58.8 million, compared to $48.4 million for the same period in the prior year, representing an increase of approximately 21% driven primarily by increased breadth of the ARISTADA provider base and growth of the ARISTADA two-month dose. Manufacturing and royalty revenues were $116.5 million, compared to $127.9 million for the same period in the prior year. Manufacturing and royalty revenues from RISPERDAL CONSTA, INVEGA SUSTENNA/XEPLION and INVEGA TRINZA/TREVICTA were $83.1 million, compared to $91.9 million for the same period in the prior year, primarily driven by a decrease in manufacturing and royalty revenues related to RISPERDAL CONSTA. Costs and Expenses Total operating expenses were $281.2 million, compared to $315.8 million for the same period in the prior year. Research and Development (R&D) expenses were $94.2 million, compared to $104.4 million for the same period in the prior year. Selling, General and Administrative (SG&A) expenses were $132.0 million, compared to $155.1 million for the same period in the prior year. Balance Sheet At June 30, 2020, Alkermes recorded cash, cash equivalents and total investments of $539.6 million, compared to $549.7 million at March 31, 2020. Cash on hand at June 30, 2020 significantly exceeded the company's total debt outstanding of $276.1 million under its term loan, which matures in March 2023. "Our second quarter results reflect solid execution across the business. The performance of the ARISTADA product family, together with disciplined management of expenses, partially offset the negative impact on VIVITROL net sales that resulted from COVID-19-related decreases in patient visits to healthcare providers and treatment centers. With increased visibility into the expected impact of COVID-19 on our commercial portfolio, today we are issuing financial expectations for 2020 that reflect current trends and underscore our commitment to driving non-GAAP profitability," commented James Frates, Chief Financial Officer of Alkermes. "Over the past five years, we have grown our topline while investing in the future growth drivers of our business. Directly as a result of those investments, we established VIVITROL as an important therapeutic option for patients with opioid and alcohol dependence; we secured FDA approvals for the ARISTADA product family; we developed ALKS 3831 and submitted a New Drug Application for schizophrenia and bipolar I disorder; we built commercial psychiatry capabilities that support the growth of ARISTADA and which are also fully leverageable for ALKS 3831; we successfully developed VUMERITY and entered into a commercial collaboration that will provide 100% gross margin royalty revenues from net sales; we advanced development of ALKS 4230 while retaining optionality for strategic collaboration; and, we acquired a platform of histone deacetylase (HDAC) inhibitors that we believe will provide compelling pipeline opportunities in neurodegeneration and oncology. We are focused on executing our business strategy and believe these investments have positioned the business to drive long-term profitability and value creation." Financial Expectations for 2020 The following financial expectations for 2020 reflect the anticipated net impacts of the COVID-19 pandemic on Alkermes' operating and financial results. Alkermes anticipates that the negative impact of COVID-19 on VIVITROL net sales will be partially offset by a decrease in operating expenses, notably within R&D. The ranges provided are based on current trends and assume that treatment provider practices and patient flow will continue to normalize. Additional wide-spread COVID-19-related restrictions or resurgence of COVID-19 could negatively impact the company's ability to meet these expectations. All line items are according to GAAP, except as otherwise noted. In millions (except per share amounts) Current 2020 Expectation (Provided 7/29/20) Pre-COVID-19 Expectation (Provided 2/13/20; Suspended 4/29/20) Total Revenue $965 $1,005 $1,030 $1,080 VIVITROL Net Sales $270 $300 $340 $355 ARISTADA Net Sales $220 $235 $220 $235 Cost of Goods Sold $180 $190 $185 $195 R&D Expenses $370 $395 $405 $430 SG&A Expenses $525 $550 $535 $560 Amortization of Intangible Assets ~$40 ~$40 Other Income, Net $10 $15 Income Tax Expense $10 $15 $0 $10 GAAP Net Loss ($145) ($175) ($130) ($160) GAAP Net Loss per Share ($0.91) ($1.10) ($0.82) ($1.01) Non-GAAP Net Income $0 $30 $40 $70 Non-GAAP Basic EPS $0.00 $0.19 $0.25 $0.44 Non-GAAP Diluted EPS $0.00 $0.19 $0.25 $0.43 Capital Expenditures ~$35 $45 $55 Governance Update "Over the past 12 months, we conducted extensive shareholder outreach and engaged with shareholders representing approximately 60% in value of our outstanding ordinary shares. The Board values the views of our shareholders and, after considering their feedback, is taking actions to further strengthen our business and corporate governance practices. The Board believes these actions will help to position the company for long-term growth as we execute on our strategy," said David Anstice, Lead Independent Director of the Alkermes Board of Directors (the Board). The company announced today that it plans to take a series of actions as part of its commitment to corporate governance best practices and regular Board refreshment. First, the Board will recommend that shareholders approve, at the company's 2021 Annual General Meeting of Shareholders, an amendment to the company's Articles of Association to declassify the Board. Currently, the Board has three classes of directors, with directors in each class elected to three-year terms. Once the Board is declassified, the directors will be combined into a single class elected annually. Second, the Board has engaged a leading recruitment firm to identify independent director candidates whose experience and expertise offer valuable insights and strategic leadership at this stage in Alkermes' evolution. As part of this process, the company expects certain of its longer-serving directors will retire from the Board. This Board refreshment process will continue and build on the efforts undertaken by the company in the fall of 2019 that led to the addition of two highly-qualified, independent directors, Dr. Richard Gaynor and Mr. Andy Wilson, to the Board. Recent Events Schizophrenia portfolio In May 2020, presented new research from the company's schizophrenia portfolio at the American Society of Clinical Psychopharmacology (ASCP) 2020 Annual Meeting, including data from patient-reported evaluations relating to treatment with ALKS 3831 and satisfaction data relating to treatment with ARISTADA. In July 2020, announced a new survey conducted by The Harris Poll for Alkermes, which explored the current use and future potential of telepsychiatry services during and after the COVID-19 pandemic. ALKS 4230 In June 2020, presented positive preclinical data from a study designed to evaluate the combination potential of ALKS 4230, Alkermes' investigational engineered interleukin-2 (IL-2) variant immunotherapy, with lucitanib, Clovis Oncology, Inc.'s investigational angiogenesis inhibitor, at the American Association for Cancer Research (AACR) Virtual Annual Meeting II. Corporate citizenship In June 2020, announced that 10 nonprofit organizations were awarded grants from the company's COVID-19 Relief Fund, a special edition of the company's signature Alkermes Inspiration Grants program, that was established to assist nonprofit organizations in their work to rapidly address pandemic-related needs for people living with addiction, serious mental illness, or cancer. In July 2020, published Alkermes' latest Corporate Responsibility Report which outlines how the company integrates environmental, social and governance considerations into all aspects of its business. A copy of the report is available on the Responsibility section of Alkermes' website. Conference Call Alkermes will host a conference call and webcast presentation with accompanying slides at 8:00 a.m. ET (1:00 p.m. BST) on Wednesday, July 29, 2020, to discuss these financial results, financial expectations, and provide an update on the company. The webcast may be accessed on the Investors section of Alkermes' website at www.alkermes.com. The conference call may be accessed by dialing +1 877 407 2988 for U.S. callers and +1 201 389 0923 for international callers. In addition, a replay of the conference call will be available from 11:00 a.m. ET (4:00 p.m. BST) on Wednesday, July 29, 2020, through Wednesday, Aug. 5, 2020, and may be accessed by visiting Alkermes' website or by dialing +1 877 660 6853for U.S. callers and +1 201 612 7415 for international callers. The replay conference ID is 13707215. About Alkermes plc Alkermes plc is a fully integrated, global biopharmaceutical company developing innovative medicines in the fields of neuroscience and oncology. The company has a portfolio of proprietary commercial products focused on addiction and schizophrenia, and a pipeline of product candidates in development for schizophrenia, bipolar I disorder, neurodegenerative disorders and cancer. Headquartered in Dublin, Ireland, Alkermes plc has an R&D center in Waltham, Massachusetts; a research and manufacturing facility in Athlone, Ireland; and a manufacturing facility in Wilmington, Ohio. For more information, please visit Alkermes'website at www.alkermes.com. Non-GAAP Financial Measures This press release includes information about certain financial measures that are not prepared in accordance with GAAP, including non-GAAP net income (loss) and non-GAAP basic and diluted earnings (loss) per share. These non-GAAP measures are not based on any standardized methodology prescribed by GAAP and are not necessarily comparable to similar measures presented by other companies. Non-GAAP net income (loss) adjusts for one-time and non-cash charges by excluding from GAAP results: share-based compensation expense; amortization; depreciation; non-cash net interest expense; changes in the fair value of the contingent consideration; certain other one-time or non-cash items; and the income tax effect of these reconciling items. The company's management and the Board utilize these non-GAAP financial measures to evaluate the company's performance. The company provides these non-GAAP measures of the company's performance to investors because management believes that these non-GAAP financial measures, when viewed with the company's results under GAAP and the accompanying reconciliations, are useful in identifying underlying trends in ongoing operations. However, non-GAAP net income (loss) and non-GAAP basic and diluted earnings (loss) per share are not measures of financial performance under GAAP and, accordingly, should not be considered as alternatives to GAAP measures as indicators of operating performance. Further, non-GAAP net income (loss) and non-GAAP basic and diluted earnings (loss) per share should not be considered measures of the company's liquidity. A reconciliation of GAAP to non-GAAP financial measures has been provided in the tables included in this press release. Note Regarding Forward-Looking Statements Certain statements set forth in this press release constitute "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, but not limited to, statements concerning: the company's expectations concerning future financial and operating performance, business plans or prospects, including the anticipated ongoing impacts of COVID-19 on the company's business and financial performance, the company's assumptions with respect to normalization of patient and healthcare provider practices, the expected growth drivers of the company's business, and the company's ability to drive significant value creation and long-term growth and profitability; the potential therapeutic and commercial value of the company's marketed and development products and the company's potential contributions to supporting patient access to such products; the company's plans for, and expectations relating to, corporate governance changes, including the proposed declassification and refreshment of the Board; expectations concerning future development activities for the company's development candidates; and expectations and timelines concerning the company's commercial activities and capabilities, including in relation to the potential launch of ALKS 3831 following U.S. Food and Drug Administration's ("FDA") review and potential approval of the new drug application ("NDA") for ALKS 3831. The company cautions that forward-looking statements are inherently uncertain. The forward-looking statements are neither promises nor guarantees and they are necessarily subject to a high degree of uncertainty and risk. Actual performance and results may differ materially from those expressed or implied in the forward-looking statements due to various risks and uncertainties. These risks and uncertainties include, among others: the impacts of the ongoing COVID-19 pandemic and continued efforts to mitigate its spread on the company's business, results of operations or financial condition, including: impacts on the vendors or distribution channels in its supply chain, and the company's ability to continue to manufacture its products; impacts on its ability to continue its discovery activities; impacts on the conduct of its clinical trials, including with respect to enrollment rates, availability of investigators and clinical trial sites and monitoring of data; impacts on healthcare systems that serve people living with opioid dependence, alcohol dependence and schizophrenia and on patient and healthcare provider access to the company's medicines; impacts on the regulatory agencies with which the company interacts in the development, review, approval and commercialization of its medicines; impacts on reimbursement for the company's products, including its Medicaid rebate liability, and for services related to the use of its products; and impacts on the U.S., Irish and/or global economies more broadly; the unfavorable outcome of litigation, including so-called "ParagraphIV" litigation and other patent litigation, related to any of the company's products or products using the company's proprietary technologies, which may lead to competition from generic drug manufacturers; clinical development activities may not be completed on time or at all; the results of the company's clinical development activities may not be positive, or predictive of real-world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the FDA or regulatory authorities outside the U.S. may make adverse decisions regarding the company's products, including decisions not to approve the company's NDAs; data from clinical trials may be interpreted by the FDA in different ways than the company interprets it; the FDA may not agree with the company's regulatory approval strategies or components of its regulatory filings, including the company's clinical trial designs, conduct and methodologies, manufacturing processes and facilities, and the adequacy of the data and other information included in its filings to meet the FDA's requirements for approval; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the company's products may prove difficult to manufacture, be precluded from commercialization by the proprietary rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse;and those risks and uncertainties described under the heading "Risk Factors" in the company's most recent Annual Report on Form 10-K and Quarterly Report on Form 10-Q and in subsequent filings made by the company with the U.S. Securities and Exchange Commission ("SEC"), which are available on the SEC's website at www.sec.gov. Existing and prospective investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. Except as required by law, the company disclaims any intention or responsibility for updating or revising any forward-looking statements contained in this press release. Trademarks VIVITROL is a registered trademark of Alkermes, Inc.; ARISTADA and ARISTADA INITIO are registered trademarks of Alkermes Pharma Ireland Limited; VUMERITYis a registered trademark ofBiogen Inc., used byAlkermesunder license;and RISPERDAL CONSTA, INVEGA SUSTENNA, XEPLION, INVEGA TRINZA andTREVICTA are registered trademarks of Johnson & Johnson. (tables follow) i The term "ARISTADA" as used in this press release refers to ARISTADA and ARISTADA INITIO, unless the context indicates otherwise. Alkermes plc and Subsidiaries Selected Financial Information (Unaudited) Condensed Consolidated Statements of Operations - GAAP Three Months Ended Three Months Ended (In thousands, except per share data) June30,2020 June30,2019 Revenues: Product sales, net $ 130,415 $ 136,635 Manufacturing and royalty revenues 116,505 127,897 Research and development revenue 609 14,340 License revenue 1,000 Total Revenues 247,529 279,872 Expenses: Cost of goods manufactured and sold 45,053 46,223 Research and development 94,222 104,435 Selling, general and administrative 132,025 155,075 Amortization of acquired intangible assets 9,890 10,062 Total Expenses 281,190 315,795 Operating Loss (33,661) (35,923) Other Income (Expense), net: Interest income 1,788 3,706 Interest expense (2,122) (3,520) Change in the fair value of contingent consideration 5,900 (6,500) Other income, net 2,337 1,851 Total Other Income (Expense), net 7,903 (4,463) Loss Before Income Taxes (25,758) (40,386) Income Tax Provision 3,673 1,604 Net Loss GAAP $ (29,431) $ (41,990) (Loss) Earnings Per Share: GAAP loss per share basic and diluted $ (0.19) $ (0.27) Non-GAAP earnings per share basic and diluted $ 0.06 $ 0.09 Weighted Average Number of Ordinary Shares Outstanding: Basic and diluted GAAP 158,895 156,991 Basic Non-GAAP 158,895 156,991 Diluted Non-GAAP 159,275 158,987 An itemized reconciliation between net loss on a GAAP basis and non-GAAP net income is as follows: Net Loss GAAP $ (29,431) $ (41,990) Adjustments: Share-based compensation expense 22,846 28,245 Depreciation expense 10,447 9,852 Amortization expense 9,890 10,062 Income tax effect related to reconciling items 877 2,043 Non-cash net interest expense 167 168 Change in the fair value of contingent consideration (5,900) 6,500 Change in the fair value of warrants and equity method investments (1,134) Non-GAAP Net Income $ 8,896 $ 13,746 Condensed Consolidated Statements of Operations - GAAP Six Months Ended Six Months Ended (In thousands, except per share data) June30,2020 June30,2019 Revenues: Product sales, net $ 260,141 $ 236,116 Manufacturing and royalty revenues 232,756 236,812 Research and development revenue 852 29,046 License Revenue 1,000 Total Revenues 493,749 502,974 Expenses: Cost of goods manufactured and sold 92,264 91,584 Research and development 187,501 207,005 Selling, general and administrative 265,397 296,295 Amortization of acquired intangible assets 19,618 20,014 Total Expenses 564,780 614,898 Operating Loss (71,031) (111,924) Other Income (Expense), net: Interest income 4,548 7,276 Interest expense (4,979) (7,020) Change in the fair value of contingent consideration 12,700 (29,100) Other income, net 1,679 130 Total Other Income (Expense), net 13,948 (28,714) Loss Before Income Taxes (57,083) (140,638) Provision (Benefit) for Income Taxes 11,002 (2,250) Net Loss GAAP $ (68,085) $ (138,388) (Loss) Earnings Per Share: GAAP loss per share basic and diluted $ (0.43) $ (0.88) Non-GAAP earnings (loss) per share basic and diluted $ 0.07 $ (0.08) Weighted Average Number of Ordinary Shares Outstanding: Basic and diluted GAAP 158,495 156,665 Basic Non-GAAP 158,495 156,665 Diluted Non-GAAP 159,151 156,665 An itemized reconciliation between net loss on a GAAP basis and non-GAAP net income (loss) is as follows: Net Loss GAAP $ (68,085) $ (138,388) Adjustments: Share-based compensation expense 42,659 52,861 Depreciation expense 21,328 19,542 Amortization expense 19,618 20,014 Income tax effect related to reconciling items 6,797 5,015 Non-cash net interest expense 334 337 Change in the fair value of contingent consideration (12,700) 29,100 Acquisition of IPR&D 674 Change in the fair value of warrants and equity method investments (701) Non-GAAP Net Income (Loss) $ 10,625 $ (12,220) Condensed Consolidated Balance Sheets June30, December 31, (In thousands) 2020 2019 Cash, cash equivalents and total investments $ 539,596 $ 614,370 Receivables 237,393 257,086 Contract assets 9,240 8,386 Inventory 116,458 101,803 Prepaid expenses and other current assets 51,705 59,716 Property, plant and equipment, net 361,807 362,168 Intangible assets, net and goodwill 223,898 243,516 Other assets 262,240 158,358 Total Assets $ 1,802,337 $ 1,805,403 Long-term debt current portion $ 2,843 $ 2,843 Other current liabilities 318,571 388,269 Long-term debt 273,207 274,295 Contract liabilities long-term 18,881 22,068 Other long-term liabilities 126,989 32,486 Total shareholders' equity 1,061,846 1,085,442 Total Liabilities and Shareholders' Equity $ 1,802,337 $ 1,805,403 Ordinary shares outstanding (in thousands) 159,028 157,779 This selected financial information should be read in conjunction with the consolidated financial statements and notes thereto included in Alkermes plc's Quarterly Report on Form 10-Q for the three and six months ended June 30, 2020, which the company intends to file in July 2020. 2020 Guidance GAAP to Non-GAAP Adjustments An itemized reconciliation between projected loss per share on a GAAP basis and projected earnings per share on a non-GAAP basis is as follows: (In millions, except per share data) Amount Shares (Loss) Earnings Per Share Projected Net Loss GAAP $ (160.0) 159 $ (1.01) Adjustments: Share-based compensation expense 97.5 Depreciation expense 44.0 Amortization expense 40.0 Income tax effect related to reconciling items 5.0 Non-cash net interest expense 1.0 Change in the fair value of contingent consideration (12.5) Projected Net Income Non-GAAP $ 15.0 161 $ 0.09 Projected GAAP and non-GAAP measures reflect mid-points within ranges of estimated guidance. Alkermes Contacts: For Investors: Sandy Coombs +1 781 609 6377For Media: Katie Joyce+1 781 249 8927 SOURCE Alkermes plc Related Links http://www.alkermes.com

Answer: Alkermes plc Reports Second Quarter 2020 Financial Results and Issues 2020 Financial Expectations