IDEA-AI4S/PubChemSFT huggingface dataset:
Molecule SMILES: [NH3+]CCc1ccc(OS(=O)(=O)[O-])cc1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a description of this molecule <molecule_2d> .

assistant: Tyramine O-sulfate is a natural product found in Bos taurus with data available.
Molecule SMILES: CCCCCC=CCC=CCCCCCCCC(=O)OC(COC(=O)CCCCCCCCCC=CCCCCCCCC)COC1OC(CO)C(O)C(O)C1O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Tell me something about this molecule: <molecule_2d>

assistant: [(2S)-2-[(9Z,12Z)-octadeca-9,12-dienoyl]oxy-3-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxypropyl] (E)-icos-11-enoate is a natural product found in Ipomoea batatas with data available.
Molecule SMILES: C=CCc1cc(OC)c(OC2OC(CO)C(O)C(O)C2OC2OC(C)C(O)C(O)C2O)c(OC)c1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: 2-[2-(2,6-Dimethoxy-4-prop-2-enylphenoxy)-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-6-methyloxane-3,4,5-triol is a natural product found in Santalum album with data available.
Molecule SMILES: CCC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)CC(N)CCCCCCC(Cl)Cl)C(=O)N(C)C(Cc1ccc(O)cc1)C(=O)N1CCCC1C(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: Unk-Tyr-Ile-N(Me)Tyr-Pro-OH is a natural product found in Microcystis aeruginosa with data available.
Molecule SMILES: CCCCCCCCCCCCCCCC(=O)NC(CCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)NCCCCC(NC(=O)C(NC(=O)C1CCCN1C(=O)C(Cc1ccc(O)cc1)NC(=O)C(CCC(=O)O)NC(=O)C(Cc1c[nH]c2ncccc12)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(NC(=O)C(CC(=O)O)N(C)C(=O)C1CC(=O)NCCCCC(NC(C)=O)C(=O)NC(C(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc2ccccc2)C(=O)N1)C(C)(C)C)C1CCCCC1)C(=O)O)C(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Please give me some details about this molecule <molecule_2d> .

assistant: Zilucoplan is under investigation in clinical trial NCT04225871 (Open-label Extension of Zilucoplan in Subjects With Generalized Myasthenia Gravis).
Molecule SMILES: CCCCCCCCCCCCCCCC(=O)NC(CCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)NCCCCC(NC(=O)C(NC(=O)C1CCCN1C(=O)C(Cc1ccc(O)cc1)NC(=O)C(CCC(=O)O)NC(=O)C(Cc1c[nH]c2ncccc12)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(NC(=O)C(CC(=O)O)N(C)C(=O)C1CC(=O)NCCCCC(NC(C)=O)C(=O)NC(C(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc2ccccc2)C(=O)N1)C(C)(C)C)C1CCCCC1)C(=O)O)C(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Tell me something about this molecule: <molecule_2d>

assistant: Zilucoplan is a synthetic macrocyclic peptide inhibitor of the terminal complement protein C5, with potential anti-inflammatory and cell protective activities. Upon subcutaneous administration, complement zilucoplan binds to a unique site in terminal complement protein C5, which blocks C5 cleavage into C5a and C5b and prevents the C5b-dependent assembly of the membrane-attack complex (MAC).  Zilucoplan also inhibits the interaction between C5b and C6, thereby further blocking MAC assembly. This prevents MAC-mediated lysis and destruction of red blood cells (RBCs) that occurs in complement-mediated diseases, such as paroxysmal nocturnal hemoglobinuria (PNH), generalized myasthenia gravis (gMG) and lupus nephritis (LN). C5, a complement pathway protein, is expressed at high levels by the liver.
Molecule SMILES: C=C(C)C1Cc2c(cc3occ(-c4ccc(O)cc4O)c(=O)c3c2O)O1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: I'd like a short overview about this molecule <molecule_2d>. Can you do that?

assistant: Lupinisoflavone A is a member of isoflavanones.
Molecule SMILES: C=C(C)C1Cc2c(cc3occ(-c4ccc(O)cc4O)c(=O)c3c2O)O1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you provide a description of this molecule <molecule_2d> ?

assistant: Lupinisoflavone A is a natural product found in Morus insignis, Lupinus texensis, and other organisms with data available.
Molecule SMILES: C(=Cc1cccs1)c1ccn[nH]1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> What do you know about the molecule?

assistant: Terevalefim is under investigation in clinical trial NCT02474667 (Reduce the Severity of DGF in Recipients of a Deceased Donor Kidney).
Molecule SMILES: COc1cc(C2OC(c3cc(OC)c4c(c3)OCO4)C(COC(C)=O)C2CO)cc2c1OCO2

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a brief overview of this molecule <molecule_2d> .

assistant: Acetic acid [(2S)-2alpha,5alpha-bis(4-methoxy-1,3-benzodioxole-6-yl)-4alpha-(hydroxymethyl)tetrahydrofuran]-3beta-ylmethyl ester is a natural product found in Peperomia humilis, Peperomia dindygulensis, and other organisms with data available.
Molecule SMILES: CC1(C)CC(=O)C=C2CC(O)(COC3OC(CO)C(O)C(O)C3O)CCC21

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Tell me something about this molecule: <molecule_2d>

assistant: (4aR,7R)-7-hydroxy-4,4-dimethyl-7-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-4a,5,6,8-tetrahydro-3H-naphthalen-2-one is a natural product found in Sedum sarmentosum with data available.
Molecule SMILES: CCC1(O)OC(OC2CC(N(C)C)C(OC3CC(O)C(OC4CCC(O)C(C)O4)C(C)O3)C(C)O2)c2c(O)c3c(c(O)c2C1CC1CC(N(C)C)C(OC2CC(O)C(OC4CCC(O)C(C)O4)C(C)O2)C(C)O1)C(=O)c1cccc(O)c1C3=O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: 4-[[4-(Dimethylamino)-5-[4-hydroxy-5-(5-hydroxy-6-methyloxan-2-yl)oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]methyl]-1-[4-(dimethylamino)-5-[4-hydroxy-5-(5-hydroxy-6-methyloxan-2-yl)oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-3-ethyl-3,5,10,12-tetrahydroxy-1,4-dihydronaphtho[2,3-g]isochromene-6,11-dione is a natural product found in Streptomyces, Streptomyces cyaneus, and other organisms with data available.
Molecule SMILES: CCCC(=O)CCC=CC=CC#CC#CC=CCO

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you provide a description of this molecule <molecule_2d> ?

assistant: (7E,9E,15Z)-17-hydroxyheptadeca-7,9,15-trien-11,13-diyn-4-one is a natural product found in Bupleurum longiradiatum with data available.
Molecule SMILES: COc1ccc(C(=O)c2ccc(C)cc2)c(O)c1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Tell me something about this molecule: <molecule_2d>

assistant: Mexenone is a member of benzophenones.
Molecule SMILES: O=c1c2ccccc2sn1-c1ccc(F)cc1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Please give me some details about this molecule <molecule_2d> .

assistant: 2-(4-fluorophenyl)-1,2-benzothiazol-3-one is a member of benzothiazoles.
Molecule SMILES: CC[Si](Cl)(Cl)c1ccccc1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Tell me something about this molecule: <molecule_2d>

assistant: Ethylphenyldichlorosilane is a colorless liquid with a pungent odor. It is decomposed by water to hydrochloric acid with evolution of heat. It is corrosive to metals and tissue.
Molecule SMILES: CCCCCCCCCCCC1=C(O)C(=O)C=C(OC(C)=O)C1=O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a brief overview of this molecule <molecule_2d> .

assistant: (4-Hydroxy-3,6-dioxo-5-undecylcyclohexa-1,4-dien-1-yl) acetate is a natural product found in Embelia schimperi with data available.
Molecule SMILES: Cc1cc(CCCOc2c(Cl)cc(C3=NCCO3)cc2Cl)on1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you provide a description of this molecule <molecule_2d> ?

assistant: 5-(3-(2,6-dichloro-4-(4,5-dihydro-2-oxazolyl)phenoxy)propyl)-3-methyl isoxazole is a solid. This compound belongs to the phenol ethers. These are aromatic compounds containing an ether group substituted with a benzene ring. Known drug targets of 5-(3-(2,6-dichloro-4-(4,5-dihydro-2-oxazolyl)phenoxy)propyl)-3-methyl isoxazole include genome polyprotein.
Molecule SMILES: NS(=O)(=O)c1cc2c(cc1Cl)CN(C1CCCCC1)C2=O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Please give me some details about this molecule <molecule_2d> .

assistant: Clorexolone is an organic molecular entity.
Molecule SMILES: NS(=O)(=O)c1cc2c(cc1Cl)CN(C1CCCCC1)C2=O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: I'd like a short overview about this molecule <molecule_2d>. Can you do that?

assistant: Clorexolone is a sulfonamide-based diuretic with thiazide-like activity. Cloreloxone has actions similar to that of thiazide diuretics.
Molecule SMILES: CC=CS(O)=S

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Tell me something about this molecule: <molecule_2d>

assistant: hydroxy-[(E)-prop-1-enyl]-sulfanylidene-lambda4-sulfane is a natural product found in Allium ascalonicum, Allium fistulosum, and other organisms with data available.
Molecule SMILES: Nc1ccn(C2OC(COP(=O)([O-])OP(=O)([O-])OC3OC(CO)C(O)C(O)C3O)C(O)C2O)c(=O)n1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a description of this molecule <molecule_2d> .

assistant: CDP-D-glucose(2-) is dianion of CDP-D-glucose. It is a conjugate base of a CDP-D-glucose.
Molecule SMILES: CCCC(O)CCC=CC=CC#CC#CCCCO

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you give me a brief overview of this molecule <molecule_2d> ?

assistant: Heptadeca-8,10-dien-4,6-diyne-1,14-diol is a natural product found in Oenanthe crocata with data available.
Molecule SMILES: COc1cc(O)c2c(=O)c3c(CC=C(C)C)cc(O)c(O)c3oc2c1CC=C(C)CCC=C(C)C

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Please give me some details about this molecule <molecule_2d> .

assistant: 4-(3,7-Dimethylocta-2,6-dienyl)-1,5,6-trihydroxy-3-methoxy-8-(3-methylbut-2-enyl)xanthen-9-one is a natural product found in Garcinia oblongifolia with data available.
Molecule SMILES: COc1c2c(nc3ccccc13)OC(C)(C)C(O)C2

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Given the molecule <molecule_2d>, what can you tell me about it?

assistant: Geibalansine is a natural product found in Citrus maxima and Melicope semecarpifolia with data available.
Molecule SMILES: CC=Cc1ccc2n(c1=O)CC1C(CO)C(C(=O)NCCc3cn(C)cn3)N(C(=O)C3CCC3)C21

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> What do you know about the molecule?

assistant: LSM-14631 is an amino acid amide.
Molecule SMILES: CC1OC(=O)C=CC(O)C=CC2CC21

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a description of this molecule <molecule_2d> .

assistant: Curvulide B2 is a natural product found in Curvularia with data available.
Molecule SMILES: CC(C)=CCc1ccc(Cl)c2[nH]cc(CC3NC(=O)C(Cc4c[nH]c5c(Cl)cccc45)NC(=O)C4CCCN4C(=O)C(CS(=O)(=O)O)NC(=O)C(NC(=O)C(NC(=O)C(C)NC(=O)CC(=O)O)C(C)C)COC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(C(C)C)NC3=O)c12

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: 3-[[(2S)-1-[[(2S)-1-[[(3S,6S,10S,13R,16R,19S,22S,25S)-22-[(7-chloro-1H-indol-3-yl)methyl]-19-[[7-chloro-4-(3-methylbut-2-enyl)-1H-indol-3-yl]methyl]-10-(hydroxymethyl)-13-(2-methylpropyl)-2,5,9,12,15,18,21,24-octaoxo-16-propan-2-yl-3-(sulfomethyl)-8-oxa-1,4,11,14,17,20,23-heptazabicyclo[23.3.0]octacosan-6-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-oxopropanoic acid is a natural product found in Streptomyces canus with data available.
Molecule SMILES: Cc1cc(=O)c2c(O)cc(OC3OC(COC4OC(C)C(O)C(O)C4O)C(O)C(O)C3O)cc2o1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Tell me something about this molecule: <molecule_2d>

assistant: 5-hydroxy-2-methylchromone-7-O-rutinoside is a disaccharide derivative that consists of 5-hydroxy-2-methylchromone substituted by a rutinosyl group at position 7 via a glycosidic linkage. Isolated from Crossosoma bigelovii, it exhibits antineoplastic activity. It has a role as a metabolite and an antineoplastic agent. It is a member of chromones, a disaccharide derivative, a member of phenols and a rutinoside.
Molecule SMILES: CC1CN(C(C)CO)C(=O)c2cc(NC(=O)Cc3ccccc3)ccc2OC1CN(C)Cc1ccc(C(=O)O)cc1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Tell me something about this molecule: <molecule_2d>

assistant: 4-[[[(2R,3S)-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-6-oxo-8-[(1-oxo-2-phenylethyl)amino]-3,4-dihydro-2H-1,5-benzoxazocin-2-yl]methyl-methylamino]methyl]benzoic acid is a member of acetamides.
Molecule SMILES: CCC=CCC=CCC=CCC=CCC=CCC=CCCCCCCCCC(O)CC(=O)SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(O)OP(=O)(O)OCC1OC(n2cnc3c(N)ncnc32)C(O)C1OP(=O)(O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Describe this molecule: <molecule_2d> .

assistant: (3R,12Z,15Z,18Z,21Z,24Z,27Z)-3-hydroxytriacontahexaenoyl-CoA is an unsaturated fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of (3R,12Z,15Z,18Z,21Z,24Z,27Z)-3-hydroxytriacontahexaenoic acid. It is a (R)-3-hydroxyacyl-CoA, a 3-hydroxy fatty acyl-CoA, an unsaturated fatty acyl-CoA and an ultra-long-chain fatty acyl-CoA. It is a conjugate acid of a (3R,12Z,15Z,18Z,21Z,24Z,27Z)-3-hydroxytriacontahexaenoyl-CoA(4-).
Molecule SMILES: CC1OC(OC2CCC3(C)C(CCC4C3C(O)CC3(C)C(C5=CC(=O)OC5)CCC43O)C2)C(O)C(O)C1O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a description of this molecule <molecule_2d> .

assistant: 3-[(3S,5R,8R,9S,10S,11R,13R,14S,17R)-11,14-dihydroxy-10,13-dimethyl-3-[(2R,3R,4R,5R,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one is a natural product found in Anodendron affine and Ornithogalum umbellatum with data available.
Molecule SMILES: O=CC1CC1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Please give me some details about this molecule <molecule_2d> .

assistant: Cyclopropanecarbaldehyde is an organooxygen compound.
Molecule SMILES: COc1cc(CO)c(CO)c(O)c1CC=C(C)CC(O)C=C(C)C

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: I'd like a short overview about this molecule <molecule_2d>. Can you do that?

assistant: 2,3-Bis(hydroxymethyl)-5-methoxy-6-[(5R)-3,7-dimethyl-5-hydroxy-2,6-octadienyl]phenol is a natural product found in Stereum with data available.
Molecule SMILES: C=C1C2CCC3=C(C(=O)C=C(C(C)C)C3=O)C2(C)CCC1(C)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: Hypoglicin J is a natural product found in Tripterygium hypoglaucum and Tripterygium wilfordii with data available.
Molecule SMILES: COc1cc(C2COC(=O)C2O)cc(OC)c1O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: Lucidulactone A is a natural product found in Ganoderma lucidum with data available.
Molecule SMILES: NCCCN1C2=CC(=NCCCN3C4=CC(=O)C(=O)c5[nH]cc(c54)CC3C(=O)O)C(=O)c3[nH]cc(c32)CC1C(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you give me a brief overview of this molecule <molecule_2d> ?

assistant: Mycenarubin B is a natural product found in Mycena rosea with data available.
Molecule SMILES: C=CC1CN2CCC1CC2C(O)c1ccnc2ccc(OC)cc12.C=CC1CN2CCC1CC2C(O)c1ccnc2ccc(OC)cc12.O=S(=O)(O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you provide a description of this molecule <molecule_2d> ?

assistant: Quinine Sulfate is the sulfate salt form of the quinidine alkaloid isolate quinine. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution.  This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
Molecule SMILES: COc1cc2[nH]c3c(c2cc1OC)CCNC31CCC2(CC3NCCc4cc(OC)c(O)c2c43)CC1OC

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> What do you know about the molecule?

assistant: CID 14655887 is a natural product found in Roemeria hybrida with data available.
Molecule SMILES: CC1CC2C(=O)OCC(NC(=O)C(Cc3cc(F)cc(F)c3)NC(=O)CCC3CCCCC3)C(=O)N3CCCC3C(=O)N3CCCCC3C(=O)NC(C)C(=O)N2C1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: I'd like a short overview about this molecule <molecule_2d>. Can you do that?

assistant: 3-Cylcohexylpropanoic acid [(S)-2-(3,5-difluorophenyl)-1-((3S,9S,13S,15R,19S,22S)-15,19-Dimethyl-2,8,12,18,21-pentaoxo-11-oxa-1,7,17,20-tetraaza-tetracyclo[20.4.0.03,7.013,17] hexacos-9-ylcarbamoyl)-ethyl]-amide is a natural product found in Streptomyces hawaiiensis with data available.
Molecule SMILES: CCCCCCCCCCCCCCCCCC(=O)NC(CCN=C(N)N)C(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: I'd like a short overview about this molecule <molecule_2d>. Can you do that?

assistant: N-Stearoyl arginine is a N-acyl-L-amino acid.
Molecule SMILES: CCCCc1nc(Cl)c(CO)n1Cc1ccc(-c2ccccc2-c2nn[n-]n2)cc1.[K+]

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Please give me some details about this molecule <molecule_2d> .

assistant: Losartan Potassium is the potassium salt of losartan, a non-peptide angiotensin II receptor antagonist with antihypertensive activity. Losartan selectively and competitively binds to the angiotensin II receptor (type AT1) and blocks the binding of angiotensin II to the receptor, thus promoting vasodilatation and counteracting the effects of aldosterone. Converted from angiotensin I by angiotensin-converting enzyme (ACE), angiotensin II stimulates the adrenal cortex to synthesize and secrete aldosterone, decreasing sodium excretion and increasing potassium excretion, and acts as a vasoconstrictor in vascular smooth muscle.
Molecule SMILES: C=C1CCC=C(C)CCC(C(C)C)C(=O)C1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Describe this molecule: <molecule_2d> .

assistant: (+)-Preisocalamenediol is a germacrane sesquiterpenoid. It has a role as a metabolite.
Molecule SMILES: C=C1CCC=C(C)CCC(C(C)C)C(=O)C1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Tell me something about this molecule: <molecule_2d>

assistant: (+)-Preisocalamenediol is a natural product found in Acorus calamus and Baccharis latifolia with data available.
Molecule SMILES: COc1cc2c(N3CCN(C(=O)Nc4ccc(OC(C)C)cc4)CC3)ncnc2cc1OCCCN1CCCCC1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a description of this molecule <molecule_2d> .

assistant: Tandutinib is an N-arylpiperazine that is piperazine in which the hydrogen attached to the nitrogen at position 1 is replaced by a 6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl group, while the hydrogen attached to the nitrogen at position 4 is replaced by a (p-isopropoxyphenyl)aminocarbonyl group. Tandutinib is an inhibitor of tyrosine kinases FLT3, PDGFR and KIT. It has a role as an antineoplastic agent and an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor. It is a N-carbamoylpiperazine, a N-arylpiperazine, a member of quinazolines, a member of piperidines, an aromatic ether, a tertiary amino compound and a member of phenylureas.
Molecule SMILES: COc1cc2c(N3CCN(C(=O)Nc4ccc(OC(C)C)cc4)CC3)ncnc2cc1OCCCN1CCCCC1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you provide a description of this molecule <molecule_2d> ?

assistant: MLN518 is a novel, oral, small molecule designed to inhibit type III receptor tyrosine kinases, including FLT3, (platelet-derived growth-factor receptor) PDGFR and c-KIT. Tyrosine kinases are enzymes involved in several cellular processes and are known to be activated in cancer cells to drive tumor growth. AML patients with FLT3 mutations experience earlier disease relapse and shorter survival rates compared to patients without these mutations. Approximately 25 to 30 percent of all adult AML patients have a mutation of the FLT3 gene. The use of MLN518 to treat AML has been granted fast-track status by the U.S. Food and Drug Administration. Phase I/II trials are underway.
Molecule SMILES: COc1cc2c(N3CCN(C(=O)Nc4ccc(OC(C)C)cc4)CC3)ncnc2cc1OCCCN1CCCCC1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: Tandutinib is a piperazinyl quinazoline receptor tyrosine kinase inhibitor with antineoplastic activity. Tandutinib inhibits the autophosphorylation of FLT3 (FMS-Like Tyrosine kinase-3), c-KIT and PDGF (platelet-derived growth factor) receptor tyrosine kinases, thereby inhibiting cellular proliferation and inducing apoptosis.