IDEA-AI4S/PubChemSFT huggingface dataset:
Molecule SMILES: CC(=O)OC(COC(=O)C=Cc1ccc(O)cc1)COC(=O)C=Cc1ccc(O)cc1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: [2-Acetyloxy-3-[3-(4-hydroxyphenyl)prop-2-enoyloxy]propyl] 3-(4-hydroxyphenyl)prop-2-enoate is a natural product found in Populus lasiocarpa with data available.
Molecule SMILES: COc1ccc(C=CC2CCC2C=Cc2ccc(OC)c(OC)c2)cc1OC

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> What do you know about the molecule?

assistant: cis-1,2-Bis[(e)-3,4-dimethoxy-styryl]cyclobutane is a natural product found in Zingiber montanum with data available.
Molecule SMILES: CCC(=O)CC(O)C(CCCCC(O)c1ccccc1)OC

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a brief overview of this molecule <molecule_2d> .

assistant: Soraphen O is an aliphatic alcohol.
Molecule SMILES: COc1ccc(-c2ccc3c(N4CCOCC4)nc(N4CC(C)OC(C)C4)nc3n2)cc1CO

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Tell me something about this molecule: <molecule_2d>

assistant: Ku-0063794 is a member of the class of pyridopyrimidines that is an mTOR inhibitor and shows anti-tumour properties. It has a role as a mTOR inhibitor and an antineoplastic agent. It is a member of morpholines, a pyridopyrimidine, a monomethoxybenzene, a tertiary amino compound and a member of benzyl alcohols.
Molecule SMILES: COc1ccccc1NC(=O)N(C)CC1OCc2cn(nn2)CCCC(=O)N(C(C)CO)CC1C

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: I'd like a short overview about this molecule <molecule_2d>. Can you do that?

assistant: 1-[[(8R,9R)-6-[(2S)-1-hydroxypropan-2-yl]-8-methyl-5-oxo-10-oxa-1,6,13,14-tetrazabicyclo[10.2.1]pentadeca-12(15),13-dien-9-yl]methyl]-3-(2-methoxyphenyl)-1-methylurea is a lactam and an azamacrocycle.
Molecule SMILES: C=C(C)C(=O)OC1C(OC(C)=O)C(C)(C)C(CC(=O)OC)C2(C)C(=O)C3C(=C)C4(OC12)C(OC(C)=O)C(=O)OC(c1ccoc1)C4(C)C3O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> What do you know about the molecule?

assistant: [5,16-Diacetyloxy-13-(furan-3-yl)-11-hydroxy-7-(2-methoxy-2-oxoethyl)-6,6,8,12-tetramethyl-17-methylidene-9,15-dioxo-2,14-dioxatetracyclo[8.6.1.01,12.03,8]heptadecan-4-yl] 2-methylprop-2-enoate is a natural product found in Sandoricum indicum and Sandoricum koetjape with data available.
Molecule SMILES: [O-][Si]([O-])([O-])[O-].[Th+4]

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: I'd like a short overview about this molecule <molecule_2d>. Can you do that?

assistant: Thorite is a mineral with formula of ThSiO4 or Th(SiO4). The IMA symbol is Thr.
Molecule SMILES: CC(C)CC(NC(=O)C(CCCCN)NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1CSSCC(N)C(=O)NC(CO)C(=O)NC(CC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(C(C)O)C(=O)N1)C(C)C)C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCC(N)=O)C(=O)NC(C(=O)NC(Cc1ccc(O)cc1)C(=O)N1CCCC1C(=O)NC(CCCNC(=N)N)C(=O)NC(C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NCC(=O)NC(CO)C(=O)NCC(=O)NC(C(=O)N1CCCC1C(N)=O)C(C)O)C(C)O)C(C)O)C(C)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Given the molecule <molecule_2d>, what can you tell me about it?

assistant: Synthetic peptide, 32 residues long formulated as a nasal spray.
Molecule SMILES: O=C1c2c(O)cc(CO)cc2C(C2OC(CO)C(O)C(O)C2O)c2ccc(O)c(O)c21

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Given the molecule <molecule_2d>, what can you tell me about it?

assistant: 9(10H)-Anthracenone, 10-beta-D-glucopyranosyl-1,2,8-trihydroxy-6-(hydroxymethyl)-, (10R)- is a natural product found in Aloe africana with data available.
Molecule SMILES: CC(C)C(=O)OC1c2c(cc(O)c3c2C(=O)c2cccc(O)c2-3)C(=O)C2(C)OC12

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a description of this molecule <molecule_2d> .

assistant: Fluostatin D is a natural product found in Streptomyces, Streptomyces albidoflavus, and other organisms with data available.
Molecule SMILES: CC(C)=CC1CC(C)C2(CCC3(C)CC4C(C)=CC(=O)C4=C(CO)C(O)CC32)O1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Describe this molecule: <molecule_2d> .

assistant: 8-epi-ophiobolin J is a natural product found in Bipolaris with data available.
Molecule SMILES: NCC(=O)OCCO

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a brief overview of this molecule <molecule_2d> .

assistant: Hydroxyethyl glycine is an alpha-amino acid ester.
Molecule SMILES: CC(=CCOc1ccc2ccc(=O)oc2c1)CCC=C(C)CC(O)C(O)C(C)(C)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: 7-[[(2E,6E,9S,10R)-3,7,11-Trimethyl-9,10,11-trihydroxy-2,6-dodecadienyl]oxy]-2H-1-benzopyran-2-one is a natural product found in Heptaptera anisoptera with data available.
Molecule SMILES: CC(C)CCCCCCOS(=O)(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> What do you know about the molecule?

assistant: 7-methyloctyl hydrogen sulfate is an alkyl sulfate that is 7-methyloctyl ester of sulfuric acid. It has a role as a Daphnia pulex metabolite and a kairomone. It is a conjugate acid of a 7-methyloctyl sulfate.
Molecule SMILES: [Ra]

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Given the molecule <molecule_2d>, what can you tell me about it?

assistant: Radium-226 is an organic molecular entity.
Molecule SMILES: CC(=O)OC1C2CCC3(C)C(CCC4C5(C)CCC(=O)C(C)(C)C5CCC43C)C2(C)CCC1(C)C

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: 22a-Acetoxy-3-stictanone is a 16-oxo steroid.
Molecule SMILES: CC1=CCCC2C1(C)CCC(C)C2(C)CCC(C=O)=CC(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Please give me some details about this molecule <molecule_2d> .

assistant: 16-Oxocleroda-3,13E-dien-15-oic acid is a natural product found in Monoon viride with data available.
Molecule SMILES: O=C(CC1C=CC(NC(=O)C2CC2)C(CO)O1)NC1CCC1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Tell me something about this molecule: <molecule_2d>

assistant: N-[(2R,3S,6R)-6-[2-(cyclobutylamino)-2-oxoethyl]-2-(hydroxymethyl)-3,6-dihydro-2H-pyran-3-yl]cyclopropanecarboxamide is a member of pyrans.
Molecule SMILES: CC1=C2CC(C)(C)CC3CC3(C(=O)O)C2CC1=O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a description of this molecule <molecule_2d> .

assistant: Ophioceric acid is a natural product found in Ophioceras venezuelense with data available.
Molecule SMILES: CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)C(OCC2OC(OP(=O)([O-])OP(=O)([O-])OCC[NH3+])C(NC(=O)CC(O)CCCCCCCCCCC)C(OC(=O)CC(O)CCCCCCCCCCC)C2O)OC(CO)C1OP(=O)([O-])OP(=O)([O-])OCC[NH3+]

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Tell me something about this molecule: <molecule_2d>

assistant: Lipid A 1,4'-bis(2-aminoethyl diphosphate)(3-) is a lipid A oxoanion arising from deprotonation of the phosphate OH groups and protonation of the amino groups of lipid A 1,4'-bis(2-aminoethyl diphosphate); major species at pH 7.3. It is a conjugate base of a lipid A 1,4'-bis(2-aminoethyl diphosphate).
Molecule SMILES: CCCCCC(C)CCCC(C)CCCC(C)CCCC(C)CCCC(C)CCCOP(=O)(O)OC1OC(CO)C(O)C(O)C1O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Describe this molecule: <molecule_2d> .

assistant: Beta-D-mannosyl C30-phosphomycoketide is a mannose phosphate consisting of beta-D-mannose having a (4S,8S,12S,16S,20S)-4,8,12,16,20-pentamethylpentacosyl)phosphate group at position 1.
Molecule SMILES: CC1OC(OC(C(O)CO)C(O)CO)C(O)C(OC2OC(CO)C(O)C(O)C2O)C1O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: I'd like a short overview about this molecule <molecule_2d>. Can you do that?

assistant: Alpha-D-Glcp-(1->3)-alpha-L-Rhap-(1->3)-D-ribitol is a glycoside comprising glucose in (1->3) linkage with rhamnose, in turn linked (1->3) to D-ribitol. It has a role as a hapten. It is a glycoside and a trisaccharide. It is functionally related to a ribitol.
Molecule SMILES: COc1ccc2cc1-c1cc(ccc1O)CC1c3cc4c(cc3CCN1C)OCOc1c(OC)cc3c(c1O4)C(C2)N(C)CC3

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: I'd like a short overview about this molecule <molecule_2d>. Can you do that?

assistant: 16,27-Dimethoxy-7,22-dimethyl-29,31,33-trioxa-7,22-diazaoctacyclo[19.11.3.14,32.110,14.115,19.03,8.025,35.028,34]octatriaconta-1(32),2,4(36),10(38),11,13,15,17,19(37),25,27,34-dodecaen-13-ol is a natural product found in Pseudoxandra lucida with data available.
Molecule SMILES: CCCNC(=O)N1CC2(CN(CC3CCCCC3)C2)c2c(n(C)c3cc(OC)ccc23)C1CO

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Describe this molecule: <molecule_2d> .

assistant: (1R)-1'-(cyclohexylmethyl)-1-(hydroxymethyl)-7-methoxy-9-methyl-N-propyl-2-spiro[1,3-dihydropyrido[3,4-b]indole-4,3'-azetidine]carboxamide is a harmala alkaloid.
Molecule SMILES: CC(C(=O)O)C1CCC2(C)CCC3(C)C(CCC4C5(C)CCC(=O)C(C)(C)C5CCC43C)C12

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Please give me some details about this molecule <molecule_2d> .

assistant: (2R)-2-[(1R,3aR,5aR,5bR,7aR,11aR,11bR,13aR,13bR)-3a,5a,5b,8,8,11a-hexamethyl-9-oxo-2,3,4,5,6,7,7a,10,11,11b,12,13,13a,13b-tetradecahydro-1H-cyclopenta[a]chrysen-1-yl]propanoic acid is a natural product found in Salacia chinensis with data available.
Molecule SMILES: COC1CC(OC2C=C(C)CC3(O)C(OC(C)=O)C(O)C4=C(C(=O)c5ccc(C6CC(OC7CC(C)(O)C(OC8CCC(OC(N)=O)C(C)O8)C(C)O7)C(O)C(C)O6)c(O)c5C4=O)C23O)OC(C)C1O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> What do you know about the molecule?

assistant: Stremycin A is a natural product found in Streptomyces pratensis with data available.
Molecule SMILES: O=C(O)CC1CCc2c1[nH]c1ccc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)cc21

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Please give me some details about this molecule <molecule_2d> .

assistant: Etrasimod is under investigation in clinical trial NCT03945188 (Etrasimod Versus Placebo for the Treatment of Moderately to Severely Active Ulcerative Colitis).
Molecule SMILES: CC=CC=CC1=Cc2cc(O)c(OC3OC(CO)C(OC)C(O)C3O)c(O)c2CO1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: Indigotide A is a natural product found in Metarhizium indigoticum with data available.
Molecule SMILES: COc1cccc2cccc(OC)c12

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you give me a brief overview of this molecule <molecule_2d> ?

assistant: 1,8-Dimethoxynaphthalene is a natural product found in Erica arborea with data available.
Molecule SMILES: CC1C(c2ccc(O)cc2)OC(c2ccc(O)c(O)c2)C1C

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a description of this molecule <molecule_2d> .

assistant: 3''-Hydroxy-4-epi-larreatricin is a natural product found in Larrea tridentata with data available.
Molecule SMILES: CC(F)=C(F)C(F)=C(F)CCCCCCCO

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Please give me some details about this molecule <molecule_2d> .

assistant: 8,9,10,11-tetrafluoro-8E,10E-dodecadien-1-ol is an organofluorine compound.
Molecule SMILES: CC(C)C=CC(C)C1CCC2C3=CC(O)C4CC(O)CCC4(C)C3CCC21C

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a brief overview of this molecule <molecule_2d> .

assistant: (3S,5S,6R,9R,10R,13R,14R,17R)-10,13-dimethyl-17-[(E,2R)-5-methylhex-3-en-2-yl]-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6-diol is a natural product found in Dendronephthya gigantea with data available.
Molecule SMILES: CSCCC(NC(=O)c1csc(C2CCCN2C(=O)C(CCCN=C(N)N)NC(C)=O)n1)C(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Describe this molecule: <molecule_2d> .

assistant: Pseudotetratide A is a natural product found in Pseudomonas entomophila with data available.
Molecule SMILES: NC(N)=NC1C(O)C(N)C(OP(=O)(O)O)C(O)C1O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Given the molecule <molecule_2d>, what can you tell me about it?

assistant: 1D-3-amino-1-guanidino-1,3-dideoxy-scyllo-inositol 4-phosphate is a scyllo-inositol phosphate. It is functionally related to a scyllo-inositol.
Molecule SMILES: O=C(O)CC(=O)OCC1OC(Oc2cc(O)cc3[o+]c(-c4ccc(O)cc4)c(OC4OC(COC(=O)C=Cc5ccc(O)c(O)c5)C(O)C(O)C4O)cc23)C(O)C(O)C1OC(=O)CC(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you give me a brief overview of this molecule <molecule_2d> ?

assistant: 3-[[3-(2-Carboxyacetyl)oxy-6-[3-[6-[3-(3,4-dihydroxyphenyl)prop-2-enoyloxymethyl]-3,4,5-trihydroxyoxan-2-yl]oxy-7-hydroxy-2-(4-hydroxyphenyl)chromenylium-5-yl]oxy-4,5-dihydroxyoxan-2-yl]methoxy]-3-oxopropanoic acid is a natural product found in Salvia splendens, Salvia coccinea, and Salvia greggii with data available.
Molecule SMILES: CCC=CCC=CCC=CCCOS(=O)(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> What do you know about the molecule?

assistant: (3Z,6Z,9Z)-dodeca-3,6,9-trien-1-yl hydrogen sulfate is a sulfuric ester of (3Z,6Z,9Z)-dodeca-3,6,9-trien-1-ol. It has a role as a Daphnia pulex metabolite and a kairomone. It is an organic sulfate and a sulfuric ester. It is a conjugate acid of a (3Z,6Z,9Z)-dodeca-3,6,9-trien-1-yl sulfate.
Molecule SMILES: NCC(CCCCNC(=O)c1cccc(O)c1O)NC(=O)c1cccc(O)c1O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you give me a brief overview of this molecule <molecule_2d> ?

assistant: Myxochelin B is a member of the class of benzamides obtained by formal condensation of the 1- and 6-amino groups of hexane-1,2,6-triamine with the carboxy groups from two molecules of 2,3-dihydroxybenzoic acid followed by reduction of the amide carbonyl at position 5 to a hydroxy group. It has a role as a siderophore and a bacterial metabolite. It is a member of catechols and a member of benzamides. It is functionally related to a 2,3-dihydroxybenzoic acid.
Molecule SMILES: NCC(CCCCNC(=O)c1cccc(O)c1O)NC(=O)c1cccc(O)c1O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Given the molecule <molecule_2d>, what can you tell me about it?

assistant: Myxochelin B is a natural product found in Trypanosoma brucei with data available.
Molecule SMILES: CC(C)CC(O)C(=O)[O-]

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> What do you know about the molecule?

assistant: (R)-2-hydroxy-4-methylpentanoate is the anion of (R)-2-hydroxy-4-methylpentanoic acid. It has a role as a human metabolite. It is a hydroxy monocarboxylic acid anion and a 2-hydroxy-4-methylvalerate. It is functionally related to a valerate. It is a conjugate base of a (R)-2-hydroxy-4-methylpentanoic acid.
Molecule SMILES: C=C(COC(=O)C(O)CC=CCC1OC2C=CCC=CC(C)=CC3OC(CC=CC=CC(=O)OC(C2)C1(C)COC(=O)CCCCCCCCCCC)CC(O)C3C)C(O)CC(C)C

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a brief overview of this molecule <molecule_2d> .

assistant: [(1R,4Z,6E,9S,11S,12R,13R,14E,16Z,19E,21S,23S,24S)-11-hydroxy-23-[(Z,5R)-5-hydroxy-6-[(3R)-3-hydroxy-5-methyl-2-methylidenehexoxy]-6-oxohex-2-enyl]-12,15,24-trimethyl-3-oxo-2,22,26-trioxatricyclo[19.3.1.19,13]hexacosa-4,6,14,16,19-pentaen-24-yl]methyl dodecanoate is a natural product found in Forcepia with data available.
Molecule SMILES: CC1CCC2(OC1)OC1CC3C4CCC5CC(OC6OC(CO)C(OC7OC(CO)C(O)C(O)C7O)C(O)C6OC6OC(CO)C(O)C(O)C6O)C(O)CC5(C)C4CCC3(C)C1C2C

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Tell me something about this molecule: <molecule_2d>

assistant: (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5R,6R)-4-hydroxy-2-(hydroxymethyl)-6-[(1R,2S,4S,5'R,6R,7S,8R,9S,12S,13S,15S,16R,18R)-15-hydroxy-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-oxane]-16-yl]oxy-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol is a natural product found in Agave utahensis with data available.
Molecule SMILES: CC(C)C(NC(=O)CCC(N)C(=O)O)C(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> What do you know about the molecule?

assistant: Gamma-Glu-Val is a glutamyl-L-amino acid that is the N-(L-gamma-glutamyl) derivative of L-leucine. It has a role as a human metabolite. It is a conjugate acid of a gamma-Glu-Val(1-).
Molecule SMILES: CC(C)C(NC(=O)CCC(N)C(=O)O)C(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: I'd like a short overview about this molecule <molecule_2d>. Can you do that?

assistant: gamma-Glutamylvaline is a natural product found in Phaseolus vulgaris, Saccharomyces cerevisiae, and Trypanosoma brucei with data available.
Molecule SMILES: CC(C)=CC(=O)NC1=C(CC2=C(NC(=O)C=C(C)C)N3C(C)C4OC4C3(C)C2=O)C(=O)C2(C)C3OC3C(C)N12

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you give me a brief overview of this molecule <molecule_2d> ?

assistant: Dibohemamine A is a natural product found in Streptomyces spinoverrucosus with data available.
Molecule SMILES: NCC(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Given the molecule <molecule_2d>, what can you tell me about it?

assistant: Glycine appears as white crystals. (NTP, 1992)
Molecule SMILES: NCC(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you give me a brief overview of this molecule <molecule_2d> ?

assistant: Glycine is the simplest (and the only achiral) proteinogenic amino acid, with a hydrogen atom as its side chain. It has a role as a nutraceutical, a hepatoprotective agent, an EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor, a NMDA receptor agonist, a micronutrient, a fundamental metabolite and a neurotransmitter. It is an alpha-amino acid, a serine family amino acid and a proteinogenic amino acid. It is a conjugate base of a glycinium. It is a conjugate acid of a glycinate. It is a tautomer of a glycine zwitterion.
Molecule SMILES: NCC(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Given the molecule <molecule_2d>, what can you tell me about it?

assistant: A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.
Molecule SMILES: NCC(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: Glycine is a non-essential, non-polar, non-optical, glucogenic amino acid. Glycine, an inhibitory neurotransmitter in the CNS, triggers chloride ion influx via ionotropic receptors, thereby creating an inhibitory post-synaptic potential. In contrast, this agent also acts as a co-agonist, along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors. Glycine is an important component and precursor for many macromolecules in the cells.
Molecule SMILES: NCC(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> What do you know about the molecule?

assistant: Glycine is a metabolite found in or produced by Escherichia coli (strain K12, MG1655).
Molecule SMILES: NCC(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: Glycine is a simple, nonessential amino acid, although experimental animals show reduced growth on low-glycine diets. The average adult ingests 3 to 5 grams of glycine daily. Glycine is involved in the body's production of DNA, phospholipids and collagen, and in release of energy. Glycine levels are effectively measured in plasma in both normal patients and those with inborn errors of glycine metabolism. Nonketotic hyperglycinaemia (OMIM 606899) is an autosomal recessive condition caused by deficient enzyme activity of the glycine cleavage enzyme system (EC 2.1.1.10). The glycine cleavage enzyme system comprises four proteins: P-, T-, H- and L-proteins (EC 1.4.4.2, EC 2.1.2.10 and EC 1.8.1.4 for P-, T- and L-proteins). Mutations have been described in the GLDC (OMIM 238300), AMT (OMIM 238310), and GCSH (OMIM 238330) genes encoding the P-, T-, and H-proteins respectively. The glycine cleavage system catalyses the oxidative conversion of glycine into carbon dioxide and ammonia, with the remaining one-carbon unit transferred to folate as methylenetetrahydrofolate. It is the main catabolic pathway for glycine and it also contributes to one-carbon metabolism. Patients with a deficiency of this enzyme system have increased glycine in plasma, urine and cerebrospinal fluid (CSF) with an increased CSF: plasma glycine ratio.  (A3412). t is also a fast inhibitory neurotransmitter.