IDEA-AI4S/PubChemSFT huggingface dataset:
Molecule SMILES: CC1CN(C(C)CO)C(=O)CCCn2nncc2COC1CN(C)C(=O)Nc1ccc(N2CCN(C)CC2)cc1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: I'd like a short overview about this molecule <molecule_2d>. Can you do that?

assistant: 1-[[(8R,9R)-6-[(2S)-1-hydroxypropan-2-yl]-8-methyl-5-oxo-10-oxa-1,6,14,15-tetrazabicyclo[10.3.0]pentadeca-12,14-dien-9-yl]methyl]-1-methyl-3-[4-(4-methyl-1-piperazinyl)phenyl]urea is an azamacrocycle and a lactam.
Molecule SMILES: Cc1cc(CCCCC(=O)O)oc1CCC(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Describe this molecule: <molecule_2d> .

assistant: 4-methyl-5-carboxyethyl-2-furanpentanoic acid is a heterocyclic fatty acid.
Molecule SMILES: CCCCC(O)C=CC1=C(CC=CCCCCC(=O)O)C(=O)CC1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Given the molecule <molecule_2d>, what can you tell me about it?

assistant: (Z)-8-[2-[(E,3S)-3-hydroxyhept-1-enyl]-5-oxocyclopenten-1-yl]oct-6-enoic acid is a natural product found in Sarcophyton trocheliophorum with data available.
Molecule SMILES: COC(=O)C(C)Oc1ccc(Oc2ccc(Cl)cc2Cl)cc1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you give me a brief overview of this molecule <molecule_2d> ?

assistant: Diclofop methyl appears as colorless crystals. Decomposed by either strong acid or base. Used as a selective herbicide.
Molecule SMILES: COC(=O)C(C)Oc1ccc(Oc2ccc(Cl)cc2Cl)cc1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Please give me some details about this molecule <molecule_2d> .

assistant: Methyl 2-[4-(2,4-dichlorophenoxy)phenoxy]propanoate is a methyl ester resulting from the formal condensation of the carboxylic acid group of 2-[4-(2,4-dichlorophenoxy)phenoxy]propanoic acid with methanol. It is an aromatic ether, a dichlorobenzene, a diether and a methyl ester.
Molecule SMILES: COC(=O)C(C)Oc1ccc(Oc2ccc(Cl)cc2Cl)cc1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Tell me something about this molecule: <molecule_2d>

assistant: Herbicide for control of wild oat & foxtails in cereal crops.
Molecule SMILES: COC(=O)C(C)Oc1ccc(Oc2ccc(Cl)cc2Cl)cc1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a description of this molecule <molecule_2d> .

assistant: Diclofop-methyl is a polycyclic alkanoic acid herbicide. Diclofop-methyl undergoes hydrolysis to form diclofop-acid a compound that also exhibits herbicidal properties. Diclofop-methyl was registered in Canada in 1977 and is sold under the tradename Hoe-Grass. Diclofop-methyl is used for postemergence control of wild oats, wild millets, and other annual grass weeds in wheat, barley, rye, red fescue, and broad-leaved crops such as soya beans, sugar beet, flax, legumes, potatoes, and cucumbers. Diclofop-methyl is a selective systemic herbicide that is used primarily in the prairies. It destroys the cell membrane, prevents the translocation of assimilates to the roots, reduces the chlorophyll content, and inhibits photosynthesis and meristem activity.
Molecule SMILES: CC(=O)Nc1ccc2c(c1O)Cc1ccccc1-2

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Describe this molecule: <molecule_2d> .

assistant: 1-Hydroxy-2-acetamidofluorene is a member of fluorenes.
Molecule SMILES: O=C(OC1Cc2c(O)cc(O)c(C3c4c(O)cc(O)cc4OC(c4ccc(O)cc4)C3O)c2OC1c1ccc(O)c(O)c1)c1cc(O)c(O)c(O)c1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a brief overview of this molecule <molecule_2d> .

assistant: [(2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-8-[(2R,3R,4R)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-4-yl]-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate is a natural product found in Rumex acetosa with data available.
Molecule SMILES: NCCCCC(NC(=O)C(CCC(=O)O)NC(=O)C(N)CCC(=O)O)C(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Tell me something about this molecule: <molecule_2d>

assistant: Glu-Glu-Lys is a tripeptide containing two L-glutamic acid residues and an L-lysine residue joined in sequence. It is functionally related to a L-glutamic acid and a L-lysine.
Molecule SMILES: CC(C)CC1CC2(CCC3(C(C)C)CC23)Oc2c(C=O)c(O)c(C=O)c(O)c21

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a brief overview of this molecule <molecule_2d> .

assistant: (1'S,2S,4R,5'R)-5,7-dihydroxy-4-(2-methylpropyl)-1'-propan-2-ylspiro[3,4-dihydrochromene-2,4'-bicyclo[3.1.0]hexane]-6,8-dicarbaldehyde is a natural product found in Eucalyptus globulus with data available.
Molecule SMILES: CC(CCC(O)C(C)(C)OC1OC(CO)C(O)C(O)C1OC1OC(C)C(O)C(O)C1O)C1CCC2(C)C3CC=C4C(CCC(OC5OC(CO)C(O)C(O)C5O)C4(C)C)C3(C)C(=O)CC12C

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: (3R,8S,9S,10R,13R,14S,17R)-17-[(2S,5S)-6-[(2R,3S,4R,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2R,3S,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-6-methylheptan-2-yl]-4,4,9,13,14-pentamethyl-3-[(2S,3S,4R,5R,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,2,3,7,8,10,12,15,16,17-decahydrocyclopenta[a]phenanthren-11-one is a natural product found in Trichosanthes tricuspidata with data available.
Molecule SMILES: COc1ccc(C2Oc3c(ccc(OC)c3OC)C(OC3C(c4ccc(OC)cc4)Oc4c(ccc(OC)c4OC)C3c3cc4c(c(OC)c3OC)OC(c3ccc(OC)cc3)C(OC(C)=O)C4OC(C)=O)C2OC(C)=O)cc1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> What do you know about the molecule?

assistant: [(2R,3R,4S)-4-[[(2R,3R,4R)-4-[(2R,3S,4S)-3,4-diacetyloxy-7,8-dimethoxy-2-(4-methoxyphenyl)-3,4-dihydro-2H-chromen-6-yl]-7,8-dimethoxy-2-(4-methoxyphenyl)-3,4-dihydro-2H-chromen-3-yl]oxy]-7,8-dimethoxy-2-(4-methoxyphenyl)-3,4-dihydro-2H-chromen-3-yl] acetate is a natural product found in Senegalia caffra with data available.
Molecule SMILES: O=C(O)C1OC(Oc2ccc3c(c2)oc(=O)c2ccccc23)C(O)C(O)C1O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: I'd like a short overview about this molecule <molecule_2d>. Can you do that?

assistant: 3,4,5-Trihydroxy-6-(6-oxobenzo[c]chromen-3-yl)oxyoxane-2-carboxylic acid is a natural product found in Punica granatum with data available.
Molecule SMILES: CC(C)CCCCCCC(=O)NC(=Cc1ccc(O)cc1)C(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Given the molecule <molecule_2d>, what can you tell me about it?

assistant: Thalassotalic acid B is a natural product found in Thalassotalea with data available.
Molecule SMILES: COC1CC(OC2C(C)OC(OC3C(C)OC(OC4CC5=CCC6C(=O)C(C)(C7=CC(=O)OC7C)CCC6C5(C)CC4O)CC3OC)CC2OC)OC(C)C1O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: I'd like a short overview about this molecule <molecule_2d>. Can you do that?

assistant: (2S)-3-[(2R,4aS,4bR,6R,7R,10aR)-6-hydroxy-7-[(2S,4S,5R,6R)-5-[(2S,4S,5R,6S)-5-[(2S,4S,5R,6R)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-2,4b-dimethyl-1-oxo-4,4a,5,6,7,8,10,10a-octahydro-3H-phenanthren-2-yl]-2-methyl-2H-furan-5-one is a natural product found in Vincetoxicum atratum with data available.
Molecule SMILES: C=CC=Cc1c(C)ccc(C)c1C

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: I'd like a short overview about this molecule <molecule_2d>. Can you do that?

assistant: 2-(Buta-1,3-dien-1-yl)-1,3,4-trimethylbenzene is a natural product found in Prunus avium with data available.
Molecule SMILES: COC(=O)C1=COC(OC2OC(CO)C(OC)C(O)C2O)C2C(C)CCC12

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you provide a description of this molecule <molecule_2d> ?

assistant: 1,5,9-epi-4'-O-Methyldeoxyloganin is a natural product found in Nepeta grandiflora with data available.
Molecule SMILES: CCCCCCCCCCCCCC(=O)OC1CC(C)(C)C2(C=CC(C)=O)OC2(C)C1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you provide a description of this molecule <molecule_2d> ?

assistant: (1R)-1beta,5,5-Trimethyl-6beta-[(1E)-3-oxo-1-butenyl]-7-oxabicyclo[4.1.0]heptane-3beta-ol tetradecanoate is a natural product found in Tridax procumbens with data available.
Molecule SMILES: CC1CCC2C(C=CC(C)C2(C)C(O)=C2C(=O)C(C(C)O)N(C)C2=O)C1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you provide a description of this molecule <molecule_2d> ?

assistant: 5-(1-hydroxyethyl)-3-[hydroxy-(1,2,6-trimethyl-4a,5,6,7,8,8a-hexahydro-2H-naphthalen-1-yl)methylidene]-1-methylpyrrolidine-2,4-dione is a natural product found in Pezicula with data available.
Molecule SMILES: C=CCCCC=CC(C#CC#CC(O)C=C)OC(C)=O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> What do you know about the molecule?

assistant: [(3S,8S,9E)-3-hydroxypentadeca-1,9,14-trien-4,6-diyn-8-yl] acetate is a natural product found in Grangea maderaspatana with data available.
Molecule SMILES: CC1=CCC(C(C)=Cc2csc(C)n2)OC(=O)CC(O)C(C)C(=O)C(C)C(O)C(C)CCC1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you provide a description of this molecule <molecule_2d> ?

assistant: epothilone D1 is a natural product found in Sorangium with data available.
Molecule SMILES: CC1CCC23C(C)C(CO)=CC2(C)CCC13

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: I'd like a short overview about this molecule <molecule_2d>. Can you do that?

assistant: [(1R,2S,5R,8R,9S)-2,5,9-trimethyl-3-tricyclo[6.3.0.01,5]undec-3-enyl]methanol is a natural product found in Subergorgia suberosa with data available.
Molecule SMILES: CON=C(C(=O)NC1C(=O)N2C(C(=O)O)=C(CSc3nc(=O)c(=O)[nH]n3C)CSC12)c1csc(N)n1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: I'd like a short overview about this molecule <molecule_2d>. Can you do that?

assistant: Ceftriaxone Sodium is the sodium salt form of ceftriaxone, a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Ceftriaxone binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, ceftriaxone is more active against gram-negative bacteria and less active against gram-positive bacteria. Ceftriaxone also crosses the blood-brain barrier and reaches therapeutic concentrations in the central nervous system (CNS).
Molecule SMILES: CCCCC1CCCCCC(C)c2cc(O)c(c(O)c2)C(CCCC)CCCCCC(C)c2cc(O)c1c(O)c2

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: Merocyclophane A is a natural product found in Nostoc with data available.
Molecule SMILES: CCCc1cc(=O)oc2c3c(c4c(c12)OC(C)(C)C=C4)OC(C)C(C)C3O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Describe this molecule: <molecule_2d> .

assistant: (-)-calanolide B is an organic heterotetracyclic compound that is 11,12-dihydro-2H,6H,10H-dipyrano[2,3-f:2',3'-h]chromen-2-one substituted by a hydroxy group at position 12, methyl groups at positions 6, 6, 10 and 11 and a propyl group at position 4 (the 10S,11R,12S stereoisomer). Isolated from Calophyllum lanigerum var austrocoriaceum and Calophyllum brasiliense, it exhibits potent activity against HIV-1 reverse transcriptase. It has a role as a HIV-1 reverse transcriptase inhibitor and a plant metabolite. It is a delta-lactone, a cyclic ether, a secondary alcohol and an organic heterotetracyclic compound.
Molecule SMILES: CCCc1cc(=O)oc2c3c(c4c(c12)OC(C)(C)C=C4)OC(C)C(C)C3O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> What do you know about the molecule?

assistant: Costatolide is a natural product found in Calophyllum brasiliense and Calophyllum teysmannii with data available.
Molecule SMILES: Nc1ncnc2c1ncn2C1OC2COP(=O)([O-])OC3C(COP(=O)([O-])OC4C(O)C(COP(=O)([O-])OC2C1O)OC4n1cnc2c(N)ncnc21)OC(n1cnc2c(N)ncnc21)C3O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: Cyclic A(2'-5')pA(3'-5')pA(3'-5')p(3-) is an organophosphate oxoanion obtained by deprotonation of the phosphate OH groups of cyclic A(2'-5')pA(3'-5')pA(3'-5')p; major species at pH 7.3.
Molecule SMILES: O=C(O)CC(=O)OC1CC(O)(C(=O)O)CC(O)C1OC(=O)C=Cc1ccc(O)c(O)c1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> What do you know about the molecule?

assistant: (1S,3R,4R,5R)-3-(2-carboxyacetyl)oxy-4-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy-1,5-dihydroxycyclohexane-1-carboxylic acid is a natural product found in Solanum incanum and Solanum melongena with data available.
Molecule SMILES: C=CC1(C)C(=O)c2c(O)ccc(O)c2C2OCC(=C)C21

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a description of this molecule <molecule_2d> .

assistant: 4beta-Vinyl-2,3,3aalpha,9balpha-tetrahydro-6,9-dihydroxy-4-methyl-3-methylenenaphtho[1,2-b]furan-5(4H)-one is a natural product found in Cordia americana with data available.
Molecule SMILES: O=C(OC1C(CO)OC(O)C(O)C1O)c1cc(O)c(O)c(O)c1-c1c(O)c(O)c2oc(=O)c3cc(O)c(O)c4oc(=O)c1c2c43

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: [(2R,3S,4R,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl] 3,4,5-trihydroxy-2-(6,7,13,14-tetrahydroxy-3,10-dioxo-2,9-dioxatetracyclo[6.6.2.04,16.011,15]hexadeca-1(15),4(16),5,7,11,13-hexaen-5-yl)benzoate is a natural product found in Terminalia chebula with data available.
Molecule SMILES: CC(=O)c1cc2cc(C(C)C)oc2cc1O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Please give me some details about this molecule <molecule_2d> .

assistant: 1-(6-Hydroxy-2-propan-2-yl-1-benzofuran-5-yl)ethanone is a natural product found in Encelia farinosa and Senecio nutans with data available.
Molecule SMILES: CC(CCC=O)C1CCC2C3CCC4C(C)(C)C(O)CCC45CC35CCC12C

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a description of this molecule <molecule_2d> .

assistant: (4R)-4-[(1S,3R,6S,8R,11S,12S,15R,16R)-6-hydroxy-7,7,16-trimethyl-15-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl]pentanal is a natural product found in Euphorbia chamaesyce with data available.
Molecule SMILES: CC12c3ccc4c(c3C(=O)c3occ(c31)C(O)CC2O)CCC4=O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you give me a brief overview of this molecule <molecule_2d> ?

assistant: Demethoxyviridiol is a natural product found in Hypoxylon hinnuleum with data available.
Molecule SMILES: COC1CC2(OC(CC=Cc3coc(C)n3)C1C)OC(C(CC(O)C(C)C(O)C(C)C=C(C)C(C)=CCCC(C)=CC(N)=O)OC)C(OP(=O)(O)O)C2(C)C

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Please give me some details about this molecule <molecule_2d> .

assistant: [(2R,3S,5R,7S,8S,9S)-2-[(1R,3S,4S,5R,6S,7E,9E,13Z)-15-amino-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-15-oxopentadeca-7,9,13-trienyl]-7-methoxy-4,4,8-trimethyl-9-[(E)-3-(2-methyl-1,3-oxazol-4-yl)prop-2-enyl]-1,10-dioxaspiro[4.5]decan-3-yl] dihydrogen phosphate is a natural product found in Theonella swinhoei with data available.
Molecule SMILES: O=C(O)c1c(O)cc2c(c1O)C(O)OC(CCCCCCCO)C2

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: I'd like a short overview about this molecule <molecule_2d>. Can you do that?

assistant: (1S,3S)-1,6,8-trihydroxy-3-(7-hydroxyheptyl)isochroman-7-carboxylic acid is a natural product found in Penicillium corylophilum with data available.
Molecule SMILES: CC(C)=CCCC(C)=CCCC(C)=CCc1c(O)cc(C)c(C(=O)O)c1O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: I'd like a short overview about this molecule <molecule_2d>. Can you do that?

assistant: ilicicolinic acid B is a natural product found in Rhododendron anthopogonoides, Albatrellus dispansus, and Rhododendron anthopogon with data available.
Molecule SMILES: CC1OC(OCC2OC(Oc3c(-c4ccc(O)cc4)oc4cc(O)cc(O)c4c3=O)C(OC3OC(C)C(O)C(OC4OC(C)C(O)C(O)C4O)C3O)C(O)C2O)C(O)C(O)C1O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Tell me something about this molecule: <molecule_2d>

assistant: Mildbraedin is a natural product found in Mildbraediodendron excelsum with data available.
Molecule SMILES: C=CCC1=C(O)C(=O)C2CCC(=O)C12O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a brief overview of this molecule <molecule_2d> .

assistant: Xialenon E is a natural product found in Streptomyces with data available.
Molecule SMILES: Cc1cc2c(cc1C(=O)O)C(=O)CC1C(C)(C)CCCC21C

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a description of this molecule <molecule_2d> .

assistant: 12-Methyl-7-oxopodocarpa-8,11,13-triene-13-carboxylic acid is a natural product found in Azadirachta indica with data available.
Molecule SMILES: Oc1cc2cc(c1)Oc1c(O)cc(cc1O)CCCCCCCCCCCC2

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: 2-Oxatricyclo[18.2.2.13,7]pentacosa-1(22),3(25),4,6,20,23-hexaene-5,22,23-triol is a natural product found in Grevillea robusta with data available.
Molecule SMILES: O=C(O)CNC(=O)c1ncc(-c2cccc(Cl)c2)cc1O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Given the molecule <molecule_2d>, what can you tell me about it?

assistant: One of the most common symptoms of advanced renal disease is anemia, caused primarily by the inability of the kidney to respond to anemic conditions with a corresponding increase in [erythropoietin] (EPO) production. Treatment of anemia of chronic kidney disease (CKD) has traditionally involved the administration of exogenous erythropoiesis-stimulating agents (ESAs), such as [darbepoetin alfa], to counter the decrease in endogenous EPO production. While efficacious, the overuse of ESAs has been associated with cardiovascular complications, progression of CKD, and increases in overall mortality.  A relatively new and alternative treatment option for patients with anemia of CKD are small molecule inhibitors of hypoxia-inducible factor prolyl-hydroxylase (HIF-PH). These agents inhibit prolyl-hydroxylase domain oxygen sensors, which essentially mimics hypoxic conditions and activates hypoxia-inducible factor, a transcription factor that serves a multitude of roles, including the stimulation erythropoiesis.  Vadadustat is an orally administered inhibitor of hypoxia-inducible factor prolyl-hydroxylase (HIF-PH) which is currently approved in Japan for the treatment for anemia due to CKD in both dialysis-dependent and non-dialysis dependent adult patients, and is currently awaiting a regulatory decision by the FDA for the same indication. The safety and efficacy of vadadustat have been shown to be non-inferior to darbepoetin alfa in patients with anemia of CKD undergoing dialysis, but it did not meet the prespecified noninferiority criterion for cardiovascular safety in a similar study in patients with non-dialysis-dependent CKD.
Molecule SMILES: O=C(O)CNC(=O)c1ncc(-c2cccc(Cl)c2)cc1O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you give me a brief overview of this molecule <molecule_2d> ?

assistant: Vadadustat is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor (HIF-PHI), with potential anti-anemic and anti-inflammatory activities. Upon administration, vadadustat binds to and inhibits HIF-PH, an enzyme responsible for the degradation of transcription factors in the HIF family under normal oxygen conditions. This prevents HIF breakdown and promotes HIF activity. Increased HIF activity leads to an increase in endogenous erythropoietin production, thereby enhancing erythropoiesis. It also reduces the expression of the peptide hormone hepcidin, improves iron availability, and boosts hemoglobin (Hb) levels. HIF regulates the expression of genes in response to reduced oxygen levels, including genes required for erythropoiesis and iron metabolism. In addition, HIF 1-alpha (HIF1A) may play a role in reducing inflammation during acute lung injury (ALI) through HIF-dependent control of glucose metabolism in the alveolar epithelium.
Molecule SMILES: CC1CN(C(C)CO)C(=O)c2ccccc2-c2ccccc2COC1CN(C)S(=O)(=O)c1cn(C)cn1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Describe this molecule: <molecule_2d> .

assistant: LSM-13492 is a member of imidazoles.
Molecule SMILES: COCC=C(C)CCC=C(C)C

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a brief overview of this molecule <molecule_2d> .

assistant: 2,6-Octadiene, 1-methoxy-3,7-dimethyl- is a natural product found in Zanthoxylum chalybeum and Homalomena occulta with data available.