IDEA-AI4S/PubChemSFT huggingface dataset:
Molecule SMILES: CC(=O)NC1C(O)OC(CO)C(OC2OC(COC3OC(CO)C(O)C(O)C3OC3OC(CO)C(OC4OC(CO)C(O)C(OC5(C(=O)O)CC(O)C(NC(C)=O)C(C(O)C(O)CO)O5)C4O)C(O)C3NC(C)=O)C(O)C(O)C2O)C1O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Given the molecule <molecule_2d>, what can you tell me about it?

assistant: (2S,4S,5R,6R)-5-Acetamido-2-[(2S,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6S)-5-acetamido-6-[(2S,3S,4S,5S,6R)-2-[[(2R,3S,4S,5S,6S)-6-[(2R,3S,4R,5R)-5-acetamido-4,6-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methoxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-4-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid is a member of neuraminic acids.
Molecule SMILES: C#CC=CCC1OC2CC1OC(CC)C(Br)CC2Br

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a brief overview of this molecule <molecule_2d> .

assistant: 4,6-Dibromo-3-ethyl-9-pent-2-en-4-ynyl-2,8-dioxabicyclo[5.2.1]decane is a natural product found in Laurencia tenera with data available.
Molecule SMILES: CC(SC(=O)c1cccs1)C(=O)NCC(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a brief overview of this molecule <molecule_2d> .

assistant: Stepronin is a N-acyl-amino acid.
Molecule SMILES: CC(SC(=O)c1cccs1)C(=O)NCC(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Describe this molecule: <molecule_2d> .

assistant: Strepronin is a mucolytic drug. A mucolytic agent is any agent which dissolves thick mucus usually used to help relieve respiratory difficulties. The viscosity of mucous secretions in the lungs is dependent upon the concentrations of mucoprotein as well as the presence of disulfide bonds between these macromolecules and DNA.
Molecule SMILES: CCC1OC(=O)C=CC(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)CC(C)C(O)C=CC=CC1COC1OC(C)C(O)C(OC)C1OC

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Given the molecule <molecule_2d>, what can you tell me about it?

assistant: (3E,5S,6S,7R,9S,10R,11E,13Z,15S,16R)-6-[(2R,3R,4R,6S)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-10-hydroxy-15-[[(2S,3R,4S,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,7,9-trimethyl-1-oxacyclohexadeca-3,11,13-trien-2-one is a natural product found in Micromonospora griseorubida with data available.
Molecule SMILES: C=C1C(C)=CCC2C(C)(C)CCCC12C

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> What do you know about the molecule?

assistant: Drima-7,9-diene is a natural product found in Cistus creticus, Mangifera indica, and Apium graveolens with data available.
Molecule SMILES: COc1ccc(-c2cc3ccccc3s2)cc1C1C2C=CCC(C)C2C(=O)N1Cc1ccccc1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Please give me some details about this molecule <molecule_2d> .

assistant: (3R,3aS,7R,7aS)-3-[5-(1-benzothiophen-2-yl)-2-methoxyphenyl]-7-methyl-2-(phenylmethyl)-3a,6,7,7a-tetrahydro-3H-isoindol-1-one is a member of pyrrolidines.
Molecule SMILES: Cc1cc(C(=O)NCCc2ccc(S(=O)(=O)NC(=O)NN3CCCCCC3)cc2)no1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Please give me some details about this molecule <molecule_2d> .

assistant: Glisoxepide is one of the sulphonamide-derived oral antidiabetic drugs. It inhibits the uptake of bile acids into isolated rat hepatocytes. However it inhibits taurocholate uptake only in the absence of sodium ions. Glisoxepide uptake could be further inhibited by blockers of the hepatocellular monocarboxylate transporter, by the loop diuretic bumetanide, by 4,4'-diisothiocyano-2,2'-stilbenedisulfonate (DIDS) and by sulphate.  These results are consistent with the transport of glisoxepide via the transport system for the unconjugated bile acid cholate.
Molecule SMILES: Cc1cc(C(=O)NCCc2ccc(S(=O)(=O)NC(=O)NN3CCCCCC3)cc2)no1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: I'd like a short overview about this molecule <molecule_2d>. Can you do that?

assistant: Glisoxepide is a second-generation sulfonylurea with antihyperglycemic activity. Like other second-generation compounds, glisoxepide exerts greater binding affinity than the first-generation compounds. Glisoxepide shows peroxisome proliferator-activated receptor (PPAR) gamma agonistic activity, has a short half-life and is excreted in both the bile and urine.
Molecule SMILES: Cc1cc2c(c3c1OCO3)C(C)CCC2C(C)CC(=O)CC(C)C

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Please give me some details about this molecule <molecule_2d> .

assistant: Helioporin C is a natural product found in Heliopora coerulea with data available.
Molecule SMILES: COc1cc(O)c2c(c1)CCCC(O)C(O)C(=O)C=CCC(C)OC2=O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Tell me something about this molecule: <molecule_2d>

assistant: 2-Hydroxy-4-methoxy-6-[(4R,5S,7Z,10S)-4,5,10-trihydroxy-6-oxo-7-undecenyl]benzoic acid mu-lactone is a member of resorcinols and a macrolide.
Molecule SMILES: COc1cc(O)c2c(c1)CCCC(O)C(O)C(=O)C=CCC(C)OC2=O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: I'd like a short overview about this molecule <molecule_2d>. Can you do that?

assistant: 2-Hydroxy-4-methoxy-6-[(4R,5S,7Z,10S)-4,5,10-trihydroxy-6-oxo-7-undecenyl]benzoic acid mu-lactone is a natural product found in Phoma with data available.
Molecule SMILES: CC1c2cccc(O)c2C([O-])=C2C(=O)C3(O)C(O)=C(C(N)=O)C(=O)C(N(C)C)C3C(O)C21.CC1c2cccc(O)c2C([O-])=C2C(=O)C3(O)C(O)=C(C(N)=O)C(=O)C(N(C)C)C3C(O)C21.[Ca+2]

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a description of this molecule <molecule_2d> .

assistant: Doxycycline Calcium is the calcium salt form of doxycycline exhibiting antimicrobial activity.  Doxycycline blocks binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis.  In addition, this agent has exhibited inhibition of collagenase activity. (NCI)
Molecule SMILES: CC1c2cccc(O)c2C([O-])=C2C(=O)C3(O)C(O)=C(C(N)=O)C(=O)C(N(C)C)C3C(O)C21.CC1c2cccc(O)c2C([O-])=C2C(=O)C3(O)C(O)=C(C(N)=O)C(=O)C(N(C)C)C3C(O)C21.[Ca+2]

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: Doxycycline is an antibacterial prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of certain infections. In addition, doxycycline is FDA-approved for the prevention of malaria due to Plasmodium falciparum.
Molecule SMILES: CC1c2cccc(O)c2C([O-])=C2C(=O)C3(O)C(O)=C(C(N)=O)C(=O)C(N(C)C)C3C(O)C21.CC1c2cccc(O)c2C([O-])=C2C(=O)C3(O)C(O)=C(C(N)=O)C(=O)C(N(C)C)C3C(O)C21.[Ca+2]

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Please give me some details about this molecule <molecule_2d> .

assistant: Many of the infections for which doxycycline is FDA-approved can be opportunistic infections (OIs) of HIV.
Molecule SMILES: CCCCCc1cc(C=C2N=C(c3ccc[nH]3)C=C2OC)[nH]c1C

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Describe this molecule: <molecule_2d> .

assistant: Prodigiosin is a natural product found in Serratia marcescens with data available.
Molecule SMILES: C=C1C(=O)OC2C1CC(O)C(=C)C1CC(=O)C(=C)C12

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a brief overview of this molecule <molecule_2d> .

assistant: 5-hydroxy-3,6,9-trimethylidene-4,5,6a,7,9a,9b-hexahydro-3aH-azuleno[4,5-b]furan-2,8-dione is a natural product found in Cyrtocymura scorpioides with data available.
Molecule SMILES: CCCCCC(C)CCCCCC(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Given the molecule <molecule_2d>, what can you tell me about it?

assistant: 7-methyl lauric acid is a medium-chain fatty acid.
Molecule SMILES: Cc1cn(C2OC3(CO)COC2C3OP(O)(=S)OCC2OC(n3cnc4c(N)ncnc43)CC2OP(O)(=S)OCC23COC(C(n4cc(C)c(N)nc4=O)O2)C3OP(O)(=S)OCC2OC(n3cnc4c(=O)[nH]c(N)nc43)CC2OP(O)(=S)OCC2OC(n3cnc4c(N)ncnc43)CC2OP(O)(=S)OCC23COC(C(n4cc(C)c(=O)[nH]c4=O)O2)C3OP(O)(=S)OCC23COC(C(n4cc(C)c(=O)[nH]c4=O)O2)C3OP(O)(=S)OCC2OC(n3cnc4c(N)ncnc43)CC2OP(O)(=S)OCC23COC(C(n4cnc5c(=O)[nH]c(N)nc54)O2)C3OP(O)(=S)OCC2OC(n3ccc(N)nc3=O)CC2OP(O)(=S)OCC23COC(C(n4cnc5c(N)ncnc54)O2)C3OP(O)(=S)OCC23COC(C(n4cc(C)c(=O)[nH]c4=O)O2)C3OP(O)(=S)OCC23COC(C(n4cc(C)c(=O)[nH]c4=O)O2)C3OP(O)(=S)OCC23COC(C(n4cnc5c(N)ncnc54)O2)C3O)c(=O)nc1N

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: I'd like a short overview about this molecule <molecule_2d>. Can you do that?

assistant: Cobomarsen is a locked nucleic acid (LNA)-based oligonucleotide inhibitor of microRNA (miRNA) 155 (miR-155), with potential antineoplastic activity. Upon administration, cobomarsen targets, binds to and inhibits miR-155. This silences miR-155 and prevents the translation of certain tumor promoting genes, which leads to the induction of cancer cell apoptosis and the inhibition of tumor cell growth. miR-155, an oncogenic single-stranded, non-coding RNA that is critical to the regulation of gene expression, is overexpressed in certain tumor cell types. Up-regulation of miR-155 plays a key role in increased tumor cell proliferation and survival. The LNA is an RNA analog in which the ribose ring is locked in a particular confirmation that increases stability. Compared to the unmodified oligonucleotide, the LNA-modified oligonucleotide shows increased affinity for its target miR-155.
Molecule SMILES: CNC(C(=O)NC(C(=O)NC(C(=O)N(C)C(C(=O)N(C)C(C(=O)NCCc1ccccc1)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> What do you know about the molecule?

assistant: Rhabdopeptide L is a natural product found in Xenorhabdus budapestensis with data available.
Molecule SMILES: CCCCCCCCC(C)C(=O)N1CCCC1C(=O)NC(CC(C)CC(O)CC(=O)CC)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)NC(C(=O)NC(C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)NC(C)CN(C)CCO)C(C)C)C(C)C

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> What do you know about the molecule?

assistant: trichoderin B is a natural product found in Trichoderma with data available.
Molecule SMILES: CC(=O)OCC1(C)C(OC(C)=O)CCC2(C)C1CC(OC(C)=O)C1(C)Oc3cc(-c4ccccc4)oc(=O)c3C(O)C21

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Given the molecule <molecule_2d>, what can you tell me about it?

assistant: Phenylpyropene A is a natural product found in Penicillium griseofulvum with data available.
Molecule SMILES: [C-]1=CC=C2CCCCCCCCCCCCCC[n+]3cccc(c3)CCCCCCCCCCCN1C2

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a brief overview of this molecule <molecule_2d> .

assistant: CID 163195713 is a natural product found in Pachychalina with data available.
Molecule SMILES: C=C1CCC2OC1C1C(C(C)C)CCC21C

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a brief overview of this molecule <molecule_2d> .

assistant: 6,10-Epoxy-7(14)-isodaucane is a natural product found in Salvia sclarea and Piper obliquum with data available.
Molecule SMILES: CCCCCCCC=CCCCCCCCCC(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a description of this molecule <molecule_2d> .

assistant: (10E)-octadecenoic acid is an octadecenoic acid with a trans-double bond at position C-10. It has a role as a plant metabolite. It is a conjugate acid of a (10E)-octadecenoate.
Molecule SMILES: CC(C)CC1SSCSSS1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a brief overview of this molecule <molecule_2d> .

assistant: (4R)-4-(2-methylpropyl)-1,2,3,5,6-pentathiepane is a natural product found in Thermococcus acidaminovorans with data available.
Molecule SMILES: COC(=O)CNC(=O)C(=O)OC

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you give me a brief overview of this molecule <molecule_2d> ?

assistant: Dimethyloxalylglycine is a glycine derivative that is the diester obtained by formal condensation of the carboxy groups of N-oxalylglycine with two molecules of methanol. It has a role as a neuroprotective agent and an EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitor. It is a glycine derivative, a methyl ester and a secondary carboxamide. It is functionally related to a N-oxalylglycine.
Molecule SMILES: CCC=CC=CC=O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> What do you know about the molecule?

assistant: (E,E)-hepta-2,4-dienal is a heptadienal in which the two double bonds are located at positions 2 and 4 (the E,E-geoisomer). It has a role as a flavouring agent.
Molecule SMILES: CCC=CC=CC=O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Please give me some details about this molecule <molecule_2d> .

assistant: 2,4-Heptadienal is a natural product found in Vaccinium macrocarpon, Vaccinium vitis-idaea, and other organisms with data available.
Molecule SMILES: C=C1C2CCC3C(C2)(C(=O)C(OC(C)=O)C2C(C)(C)C=CC(=O)C23COC(C)=O)C1OC(C)=O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> What do you know about the molecule?

assistant: [(1S,3S,4R,9S,10S,13R,15R)-3,15-diacetyloxy-5,5-dimethyl-14-methylidene-2,8-dioxo-9-tetracyclo[11.2.1.01,10.04,9]hexadec-6-enyl]methyl acetate is a natural product found in Isodon longitubus with data available.
Molecule SMILES: CC(=O)OCCC(C)=CC(=O)NCCC(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Given the molecule <molecule_2d>, what can you tell me about it?

assistant: Pestalotiopamide E is a natural product found in Aureobasidium pullulans with data available.
Molecule SMILES: C=C1CC23CC1CCC2C1(C)CCCC(C)(COC(C)=O)C1CC3O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Please give me some details about this molecule <molecule_2d> .

assistant: [(1R,2S,4R,5S,9R,10S,13R)-2-hydroxy-5,9-dimethyl-14-methylidene-5-tetracyclo[11.2.1.01,10.04,9]hexadecanyl]methyl acetate is a natural product found in Sideritis cystosiphon with data available.
Molecule SMILES: CC(=O)NC(CO)C(OC1OC(CO)C(O)C(OC2(C(=O)O)CC(O)C(NC(C)=O)C(C(O)C(O)CO)O2)C1O)C(O)C(O)COC1(C(=O)O)CC(O)C(NC(C)=O)C(C(O)C(CO)OC2(C(=O)O)CC(O)C(NC(C)=O)C(C(O)C(O)CO)O2)O1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you provide a description of this molecule <molecule_2d> ?

assistant: (2R,4S,5R,6R)-5-Acetamido-2-[(2R,3S,4R,5S)-5-acetamido-4-[(2R,3R,4S,5S,6R)-4-[(2S,4S,5R,6R)-5-acetamido-2-carboxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,3,6-trihydroxyhexoxy]-6-[(1S,2R)-2-[(2S,4S,5R,6R)-5-acetamido-2-carboxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxan-2-yl]oxy-1,3-dihydroxypropyl]-4-hydroxyoxane-2-carboxylic acid is a member of neuraminic acids.
Molecule SMILES: CC1C=CC2CC(C)(O)CC(C)C2C1C=CC=CC(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: (2E,4E)-5-[(1R,2R,4aS,6S,8S,8aR)-6-hydroxy-2,6,8-trimethyl-2,4a,5,7,8,8a-hexahydro-1H-naphthalen-1-yl]penta-2,4-dienoic acid is a natural product found in Penicillium steckii and Penicillium citrinum with data available.
Molecule SMILES: CC(CCO)C(=O)NCCCCNC(=O)C=Cc1ccccc1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a description of this molecule <molecule_2d> .

assistant: (2R)-4-hydroxy-2-methyl-N-[4-[[(E)-3-phenylprop-2-enoyl]amino]butyl]butanamide is a natural product found in Aglaia tenuicaulis with data available.
Molecule SMILES: CC(=O)C1OC(Oc2ccc(C=C(C)C(=O)NC3C(O)C(O)C4OCOC4C3O)cc2O)C(O)C1O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you provide a description of this molecule <molecule_2d> ?

assistant: Hygromycin A is a hydroxycinnamic acid. It has a role as a metabolite.
Molecule SMILES: CC(=O)C1OC(Oc2ccc(C=C(C)C(=O)NC3C(O)C(O)C4OCOC4C3O)cc2O)C(O)C1O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Given the molecule <molecule_2d>, what can you tell me about it?

assistant: Hygromycin A is a natural product found in Streptomyces, Streptomyces hygroscopicus, and other organisms with data available.
Molecule SMILES: CC1(C=O)CCCC2(C)C1CCC1(C)C3Cc4cc(O)ccc4OC3(C)CCC21

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a brief overview of this molecule <molecule_2d> .

assistant: Strongylophorin-4 is a natural product found in Petrosia durissima with data available.
Molecule SMILES: O=C(CCC(NC(=O)OCc1ccccc1)C(=O)OCc1ccccc1)NNc1ccc(OCc2ccccc2)cc1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Given the molecule <molecule_2d>, what can you tell me about it?

assistant: benzyl (2S)-5-oxo-2-(phenylmethoxycarbonylamino)-5-[2-(4-phenylmethoxyphenyl)hydrazinyl]pentanoate is a natural product found in Lichina pygmaea with data available.
Molecule SMILES: CC1Oc2cc(O)c3c(=O)c4cc(O)c(O)cc4oc3c2C1(C)C

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> What do you know about the molecule?

assistant: (2S)-5,8,9-trihydroxy-1,1,2-trimethyl-2H-furo[2,3-c]xanthen-6-one is a natural product found in Hypericum perforatum with data available.
Molecule SMILES: CC1(O)CCC2(O)C(C=O)=COC(OC3OC(CO)C(O)C(O)C3O)C12

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you give me a brief overview of this molecule <molecule_2d> ?

assistant: (1S,4aR,7S,7aR)-4a,7-dihydroxy-7-methyl-1-[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,5,6,7a-tetrahydrocyclopenta[c]pyran-4-carbaldehyde is a natural product found in Pedicularis lapponica with data available.
Molecule SMILES: CC1(C)CCC2(CC1)NC(C(=O)NC1CCC(C(N)=O)OC1)C(c1ccnc(Cl)c1F)C21C(=O)Nc2cc(Cl)ccc21.Cc1ccc(S(=O)(=O)O)cc1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you provide a description of this molecule <molecule_2d> ?

assistant: Milademetan Tosylate is the tosylate form of milademetan, an orally available MDM2 (murine double minute 2) antagonist with potential antineoplastic activity. Upon oral administration, milademetan binds to, and prevents the binding of MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction, the proteasome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored. This results in the restoration of p53 signaling and leads to the p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger protein and a negative regulator of the p53 pathway, is overexpressed in cancer cells; it has been implicated in cancer cell proliferation and survival.
Molecule SMILES: CC(C)CCCCCCC=CCCCCCCCC=CC(O)C#CC#CCO

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Given the molecule <molecule_2d>, what can you tell me about it?

assistant: Strogylodiol I is a natural product found in Petrosia with data available.
Molecule SMILES: CCC(C)C(=O)OC1CC(C)C=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C21

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: (2S)-2-methylbutanoic acid [(1S,3R,7S,8S,8aS)-8-[2-[(2R,4R)-4-hydroxy-6-oxo-2-oxanyl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] ester is a delta-lactone.
Molecule SMILES: CC1=C2C(CC1)C(C)CCC1C2C1(C)C

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Describe this molecule: <molecule_2d> .

assistant: CID 16213731 is a natural product found in Cyperus rotundus and Thymus broussonetii with data available.
Molecule SMILES: CCCCCCCCCCCC=CC(O)C(COC1OC(CO)C(O)C(O)C1O)NC(=O)CCCCCCCCCCCCCCC

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Describe this molecule: <molecule_2d> .

assistant: N-[(Z,2S,3R)-3-hydroxy-1-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexadec-4-en-2-yl]hexadecanamide is a natural product found in Turbo stenogyrus with data available.
Molecule SMILES: CC=C(C)C(=O)OC1C2CCCC3C(=O)OC(C4=C(C)C(=O)OC41O)C32C

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a brief overview of this molecule <molecule_2d> .

assistant: [(1R,6R,7S,8S,12S,15S)-6-hydroxy-3,15-dimethyl-4,13-dioxo-5,14-dioxatetracyclo[6.6.1.02,6.012,15]pentadec-2-en-7-yl] (Z)-2-methylbut-2-enoate is a natural product found in Ligularia hodgsonii with data available.
Molecule SMILES: Oc1cc2c3c(ccc4cc(O)c(O)c(c43)CO2)c1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: 5H-Phenanthro[4,5-bcd]pyran-2,6,7-triol is a natural product found in Phalaenopsis equestris with data available.
Molecule SMILES: CC1CCCCOC(CN(C)C)C(C)CN(C(C)CO)C(=O)c2cc(NS(=O)(=O)c3ccccc3)ccc2O1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Given the molecule <molecule_2d>, what can you tell me about it?

assistant: N-[(3S,9R,10S)-9-[(dimethylamino)methyl]-12-[(2S)-1-hydroxypropan-2-yl]-3,10-dimethyl-13-oxo-2,8-dioxa-12-azabicyclo[12.4.0]octadeca-1(14),15,17-trien-16-yl]benzenesulfonamide is an azamacrocycle and a lactam.