IDEA-AI4S/PubChemSFT huggingface dataset:
Molecule SMILES: CC(=O)OC1C2CCC3C(C)(O)C4CC(O)C(C)(C)C4(O)C(O)CC13CC2(C)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you give me a brief overview of this molecule <molecule_2d> ?

assistant: Rhodotoxine is a natural product found in Rhododendron metternichii and Rhododendron dauricum with data available.
Molecule SMILES: CCC(C)C(=NOS(=O)(=O)O)SC1OC(CO)C(O)C(O)C1O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Given the molecule <molecule_2d>, what can you tell me about it?

assistant: [(2R,3R,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1Z,2R)-2-methyl-N-sulfooxybutanimidothioate is a natural product found in Moringa peregrina, Brassica rapa, and other organisms with data available.
Molecule SMILES: COC(=O)C12OCC34C(CC5C(C)=C(OC6OC(CO)C(O)C(O)C6O)C(=O)CC5(C)C3C(O)C1O)OC(=O)C(OC(=O)C=C(C)C(C)(C)O)C24

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Please give me some details about this molecule <molecule_2d> .

assistant: Yadazioside L is a natural product found in Brucea javanica with data available.
Molecule SMILES: CC(O)C(=O)C1(C)CCC2C3CCC4=CC(=O)CCC4=C3CCC21C

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Given the molecule <molecule_2d>, what can you tell me about it?

assistant: Trimegestone is a 20-oxo steroid.
Molecule SMILES: CC(O)C(=O)C1(C)CCC2C3CCC4=CC(=O)CCC4=C3CCC21C

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Given the molecule <molecule_2d>, what can you tell me about it?

assistant: Trimegestone has been used in trials studying the treatment of Postmenopause.
Molecule SMILES: CC=C1NC(=O)C(C(C)C)NC1=O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Tell me something about this molecule: <molecule_2d>

assistant: Brevibactin B is a natural product found in Brevibacterium with data available.
Molecule SMILES: CC(C(=O)O)C(C)(O)CC(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: 2,3-Dimethyl-3-hydroxyglutaric acid is a hydroxy fatty acid.
Molecule SMILES: CC(=O)C1CC2(C)C3(CO3)C1OC1C=C(C)C(=O)C(O)C12CO

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Tell me something about this molecule: <molecule_2d>

assistant: 3-Acetyl Deoxynivalenol is a natural product found in Fusarium, Fusarium culmorum, and Fusarium graminearum with data available.
Molecule SMILES: COC(=O)C(C)CC(=O)CC(C)C1CC(=O)C2(C)C3=C(C(=O)C(OC(C)=O)C12C)C1(C)CCC(O)C(C)(C)C1CC3=O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Given the molecule <molecule_2d>, what can you tell me about it?

assistant: methyl (2R,6R)-6-[(3S,5R,10S,12S,13R,14R,17R)-12-acetyloxy-3-hydroxy-4,4,10,13,14-pentamethyl-7,11,15-trioxo-1,2,3,5,6,12,16,17-octahydrocyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxoheptanoate is a natural product found in Ganoderma lucidum with data available.
Molecule SMILES: CC1OC(OC2C(OC(=O)C34CCC(C)(C)CC3C3=CCC5C6(C)CCC(OC7OC(C(=O)O)C(O)C(O)C7OC7OC(CO)C(O)C(O)C7O)C(C)(C=O)C6CCC5(C)C3(C)CC4O)OCC(O)C2O)C(O)C(O)C1OC1OCC(O)C(O)C1O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: (2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8R,8aR,12aS,14aR,14bR)-8a-[(2S,3R,4S,5S)-3-[(2S,3R,4S,5R,6S)-3,4-dihydroxy-6-methyl-5-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-4,5-dihydroxyoxan-2-yl]oxycarbonyl-4-formyl-8-hydroxy-4,6a,6b,11,11,14b-hexamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4-dihydroxy-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-2-carboxylic acid is a natural product found in Thladiantha dubia with data available.
Molecule SMILES: CSCCC(NC(=O)C(Cc1ccccc1)NCC(NCC(N)CS)C(C)C)C(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: I'd like a short overview about this molecule <molecule_2d>. Can you do that?

assistant: B 581 is a dipeptide obtained from the tetrapeptide Cys-Val-Phe-Met by reduction of the amide carbonyl groups of the Cys and Val residues. It has a role as a peptidomimetic and an EC 2.5.1.58 (protein farnesyltransferase) inhibitor.
Molecule SMILES: COc1cc2c(=O)c(-c3cc(Cl)c(O)c(Cl)c3)coc2cc1O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you give me a brief overview of this molecule <molecule_2d> ?

assistant: Maduraktermol B is a natural product found in Actinomadura with data available.
Molecule SMILES: O=C(O)C1(O)CC(OC2(C(=O)O)OC(C(O)CO)C(O)C(O)C2O)C(O)C(C(O)CO)O1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Describe this molecule: <molecule_2d> .

assistant: Alpha-D-Ko-(2->4)-alpha-D-Kdo is a disaccharide comprising a D-glycero-alpha-D-talo-oct-2-ulosonyl unit in (2->4) linkage with 3-deoxy-alpha-D-manno-oct-2-ulopyranonosonic acid; it forms part of the core structure of bacterial lipopolysaccharides.
Molecule SMILES: CSC(=O)CC12OC(C(C)C3(O)CCC4C5C(OC(C)=O)CC67OC6C(=O)C=CC7(C)C5CCC43C)CC(C)(O1)C(C)(C)O2

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Given the molecule <molecule_2d>, what can you tell me about it?

assistant: [(1S,2R,6R,8R,10R,11S,12S,15R,16S)-15-hydroxy-2,16-dimethyl-5-oxo-15-[(1R)-1-[(1S,3R,5R)-5,6,6-trimethyl-1-(2-methylsulfanyl-2-oxoethyl)-2,7,8-trioxabicyclo[3.2.1]octan-3-yl]ethyl]-7-oxapentacyclo[9.7.0.02,8.06,8.012,16]octadec-3-en-10-yl] acetate is a natural product found in Petunia axillaris with data available.
Molecule SMILES: CCC(SSC)S(C)=O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> What do you know about the molecule?

assistant: Methyl 1-(methylsulfinyl)propyl disulfide is a sulfoxide.
Molecule SMILES: CC1C(=O)CCC2C1(C)CCC1C2(C)CCC2(C)C3CC(C)(C(=O)O)CCC3(C)CCC12C

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: I'd like a short overview about this molecule <molecule_2d>. Can you do that?

assistant: Octandronic acid is a natural product found in Salacia reticulata, Osyris quadripartita, and other organisms with data available.
Molecule SMILES: CC1(O)CCC2C(C(=O)O)=COC(OC3OC(CO)C(O)C(O)C3O)C21

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: (1S,4aS,7S,7aS)-7-hydroxy-7-methyl-1-[(2R,3S,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4a,5,6,7a-tetrahydro-1H-cyclopenta[c]pyran-4-carboxylic acid is a natural product found in Gardenia jasminoides, Cistanche tubulosa, and other organisms with data available.
Molecule SMILES: CC(=CCCC1C(C)=CCC2C(C)(C)C(=O)CCC12C)CCC=C(C)CCC(O)C(C)(C)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Please give me some details about this molecule <molecule_2d> .

assistant: Lamesticumin F is a triterpenoid of the class of onoceranoid-type terpenoids isolated from the twigs of Lansium domesticum. It has a role as a metabolite, an antibacterial agent and a plant metabolite. It is a cyclic terpene ketone, a triterpenoid, a diol and a member of hexahydronaphthalenes.
Molecule SMILES: CC(=CCCC1C(C)=CCC2C(C)(C)C(=O)CCC12C)CCC=C(C)CCC(O)C(C)(C)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: Lamesticumin F is a natural product found in Dysoxylum parasiticum and Lansium domesticum with data available.
Molecule SMILES: CC(CO)CCCC(C)C1=CCC2(C)OC3=C(CC12)C(=O)C(O)CC3

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Tell me something about this molecule: <molecule_2d>

assistant: (3aS,7S,9aR)-7-hydroxy-1-[(2R,6S)-7-hydroxy-6-methylheptan-2-yl]-3a-methyl-3,5,6,7,9,9a-hexahydrocyclopenta[b]chromen-8-one is a natural product found in Alternaria alternata with data available.
Molecule SMILES: CC1=CC2(CC1)C(C)CCC(C(C)C)C2N=C=S

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Tell me something about this molecule: <molecule_2d>

assistant: (5R,6S,9R,10R)-10-isothiocyanato-3,6-dimethyl-9-propan-2-ylspiro[4.5]dec-3-ene is a natural product found in Acanthella cavernosa with data available.
Molecule SMILES: COc1ccc(C2=NC(c3ccc(Cl)cc3)C(c3ccc(Cl)cc3)N2C(=O)N2CCNC(=O)C2)c(OC(C)C)c1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you give me a brief overview of this molecule <molecule_2d> ?

assistant: Rebemadlin is a small molecule and MDM2 (murine double minute 2) inhibitor, with potential antineoplastic activity. In cancer cells, rebemadlin antagonizes the binding of MDM2 to p53, thereby preventing MDM2-mediated p53 degradation. This results in stabilizing and activating p53-dependent cell cycle arrest and apoptosis. The protein MDM2, a negative regulator of p53 activity, is overexpressed in many cancer cell types; the tumor suppressor p53 is mutated or deleted in about 50% of all cancers but active in the other 50%.
Molecule SMILES: COc1ccc(C2=NC(c3ccc(Cl)cc3)C(c3ccc(Cl)cc3)N2C(=O)N2CCNC(=O)C2)c(OC(C)C)c1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Tell me something about this molecule: <molecule_2d>

assistant: Nutlin-3 is a small molecule inhibitor that targets p53-Mdm2 interaction.
Molecule SMILES: C=C(C)C1CCC2(C)C(O)C(O)CC(C)C2C1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you provide a description of this molecule <molecule_2d> ?

assistant: Penicieudesmol A is a natural product found in Penicillium with data available.
Molecule SMILES: COc1cc(CCCCC(=O)O)ccc1O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> What do you know about the molecule?

assistant: 5-(4-hydroxy-3-methoxyphenyl)pentanoic acid is a member of phenols and a member of methoxybenzenes.
Molecule SMILES: C1CC2CCC1C2

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a description of this molecule <molecule_2d> .

assistant: Norbornane is a cyclic hydrocarbon consisting of cyclohexane with a methylene bridge linking positions 1 and 4. It is a bridged compound and a cyclic hydrocarbon.
Molecule SMILES: CC(C)C#Cc1cnc2c(c1)C(=O)N(C(C)CO)CC(C)C(CN(C)Cc1cncnc1)O2

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a brief overview of this molecule <molecule_2d> .

assistant: (2S,3S)-5-[(2R)-1-hydroxypropan-2-yl]-3-methyl-8-(3-methylbut-1-ynyl)-2-[[methyl(5-pyrimidinylmethyl)amino]methyl]-3,4-dihydro-2H-pyrido[2,3-b][1,5]oxazocin-6-one is an aromatic ether.
Molecule SMILES: NC(CO)C(=O)NC(Cc1ccccc1)C(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> What do you know about the molecule?

assistant: Ser-Phe is a dipeptide that is the N-(L-seryl) derivative of L-phenylalanine. It has a role as a metabolite. It is functionally related to a L-serine and a L-phenylalanine.
Molecule SMILES: NC(CO)C(=O)NC(Cc1ccccc1)C(=O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Please give me some details about this molecule <molecule_2d> .

assistant: Ser-phe is a natural product found in Arabidopsis thaliana with data available.
Molecule SMILES: CC(=O)OCC1OC(OC(C)C=C=C2C(C)(C)CC(OC(C)=O)CC2(C)O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a description of this molecule <molecule_2d> .

assistant: CID 162945599 is a natural product found in Lycium barbarum with data available.
Molecule SMILES: CC1=CC(=O)C(O)C2(C)C1CC1OC(=O)C(O)C3(O)C4(CO)OCC13C2C(O)C4O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: I'd like a short overview about this molecule <molecule_2d>. Can you do that?

assistant: yadanziolide A is a natural product found in Brucea javanica and Brucea mollis with data available.
Molecule SMILES: COc1cc2[nH]c3ccc4c(c3c2cc1C)C=CC(C)(C)O4

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: 7-Methoxyglycomaurin is a natural product found in Glycosmis mauritiana with data available.
Molecule SMILES: COc1ccc(C=C2Oc3cc(O)c(C)c(OC)c3C2=O)cc1O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a description of this molecule <molecule_2d> .

assistant: 6,3'-Dihydroxy-4,4'-dimethoxy-5-methylaurone is a natural product found in Cyperus capitatus with data available.
Molecule SMILES: CN1C(=O)C(O)(Cc2ccc(O)c(O)c2)N(C)C(=O)C1Cc1c[nH]c2cccc([N+](=O)[O-])c12

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: (2R,5S)-1,4-Dimethyl-2-hydroxy-2-(3,4-dihydroxybenzyl)-5-[(4-nitro-1H-indol-3-yl)methyl]piperazine-3,6-dione is a natural product found in Streptomyces scabiei with data available.
Molecule SMILES: CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CCOP(=O)(O)OP(=O)(O)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Please give me some details about this molecule <molecule_2d> .

assistant: Nonaprenyl diphosphate is a polyprenol diphosphate compound having nine prenyl units with undefined stereochemistry about the double bonds. It has a role as a Saccharomyces cerevisiae metabolite.
Molecule SMILES: COc1cc(C2OCC3C(c4cc(OC)c5c(c4)OCO5)OCC23)cc(OC)c1O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you provide a description of this molecule <molecule_2d> ?

assistant: (1S,2R,5S,6R)-2-(4-Methoxy-1,3-benzodioxole-6-yl)-6-(4-hydroxy-3,5-dimethoxyphenyl)-3,7-dioxabicyclo[3.3.0]octane is a natural product found in Peperomia heyneana with data available.
Molecule SMILES: [Cl-].[Cl-].[Cl-].[Sb+3]

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you give me a brief overview of this molecule <molecule_2d> ?

assistant: Antimony trichloride is the chemical compound with the formula SbCl3. The soft colorless solid with a pungent odor was known to the alchemists as butter of antimony. Antimony is a metallic element with the chemical symbol Sb and atomic number 51. Small amounts of antimony are found in the earth's crust. (L741, L767)
Molecule SMILES: OCC1OC(SC(Cc2c[nH]c3ccccc23)=NO)C(O)C(O)C1O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you give me a brief overview of this molecule <molecule_2d> ?

assistant: (Z)-indolylmethyl desulfoglucosinolate is an indolylmethyl desulfoglucosinolate in which the C=N double bond has Z configuration.
Molecule SMILES: COc1ccccc1-c1ccc(C2C(CO)N(CC3CC3)C23CN(S(C)(=O)=O)C3)cc1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a description of this molecule <molecule_2d> .

assistant: [(2S,3R)-1-(cyclopropylmethyl)-3-[4-(2-methoxyphenyl)phenyl]-6-methylsulfonyl-1,6-diazaspiro[3.3]heptan-2-yl]methanol is a member of biphenyls.
Molecule SMILES: O=C(NCC1CCCCC1)C1C(CO)C2Cn3c(cccc3=O)C1N2C(=O)c1cccnc1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Provide a brief overview of this molecule <molecule_2d> .

assistant: LSM-8759 is an aromatic carboxylic acid and a pyridinemonocarboxylic acid.
Molecule SMILES: COC(=O)c1c(OC2OC(C)C(O)C(OC)C2OC)cc2cc3c(c(O)c2c1C)C(=O)C1(O)C(=O)C=C(OC)C(O)C1(O)C3=O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> What do you know about the molecule?

assistant: methyl 6a,7,10a,12-tetrahydroxy-3-(5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl)oxy-8-methoxy-1-methyl-6,10,11-trioxo-7H-tetracene-2-carboxylate is a natural product found in Streptomyces olivaceus with data available.
Molecule SMILES: COc1cc(OC)c(-c2coc3cc(O)cc(O)c3c2=O)c(OC)c1O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Given the molecule <molecule_2d>, what can you tell me about it?

assistant: 5,7-Dihydroxy-3-(3-hydroxy-2,4,6-trimethoxyphenyl)chromen-4-one is a natural product found in Garcinia nervosa with data available.
Molecule SMILES: COC12CC3CCCC(C)C3(C)C(O)C1=C(C)C(=O)O2

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Tell me something about this molecule: <molecule_2d>

assistant: (4S)-4a,5,6,7,8,8abeta,9,9a-Octahydro-4beta-hydroxy-9aalpha-methoxy-3,4abeta,5beta-trimethylnaphtho[2,3-b]furan-2(4H)-one is a natural product found in Ligularia fischeri and Petasites japonicus with data available.
Molecule SMILES: CSCCC1NC(=O)c2csc(n2)CNC(=O)C2N=C(OC2C)C(Cc2ccccc2)NC(=O)C2CSC1=N2

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you give me a brief overview of this molecule <molecule_2d> ?

assistant: Aeruclynamide D is a cyclic peptide.
Molecule SMILES: CCC(C)C(NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CC(=O)O)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCC(N)=O)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CCC(=O)O)NC(=O)C(CO)NC(=O)C(NC(=O)C(C)N)C(C)C)C(=O)NC(CCC(N)=O)C(=O)NC(CC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C)(C)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(C(=O)NC(C)C(N)=O)C(C)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Please give me some details about this molecule <molecule_2d> .

assistant: Abaloparatide is an analog of PTHrP (parathyroid hormone-related protein). It was approved in April 28, 2017 by the FDA (as Tymlos) for the treatment of postmenopausal women with osteoporosis at high risk for fracture. Abaloparatide is a synthetic peptide that is related to hPTHrP and has demonstrated in preclinical testing the potential to widen the anabolic window for bone therapeutics, stimulating bone formation with a limited effect on bone resorption and mineral mobilization. This could enable improved convenience over currently available anabolic therapies, resulting in greater compliance and, ultimately, greater benefit to patients.  In October 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP) recommended abaloparatide be granted marketing authorization in Europe for the treatment of osteoporosis in postmenopausal women at increased risk of fracture. In December 2022, the FDA indication for abaloparatide was expanded to include male patients in addition to postmenopausal women.
Molecule SMILES: CCC(C)C(NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(CCCCN)NC(=O)C(CC(=O)O)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCC(N)=O)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(CCC(=O)O)NC(=O)C(CO)NC(=O)C(NC(=O)C(C)N)C(C)C)C(=O)NC(CCC(N)=O)C(=O)NC(CC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(C)(C)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(C(=O)NC(C)C(N)=O)C(C)O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Please give me some details about this molecule <molecule_2d> .

assistant: Abaloparatide is a 34 amino acid synthetic analog of human parathyroid hormone-related protein (PTHrP) (PTHrP(1-34) analog), with bone-growing and bone density conserving activities. Upon subcutaneous administration, abaloparatide acts similar to PTHrP and targets, binds to and activates parathyroid hormone 1 (PTH1) receptor (PTH1R), a G protein-coupled receptor (GPCR) expressed in osteoblasts and bone stromal cells. PTH1R activates the cyclic AMP (cAMP) signaling pathway and the bone anabolic signaling pathway, leading to bone growth, increased bone mineral density (BMD) and volume. This correlates with increased bone mass and strength and prevents or treats osteoporosis and decreases fractures.
Molecule SMILES: COC1=CC(=O)C2C(O)=C(C)C3=C(OC(C)C3)C2C1=O

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Given the molecule <molecule_2d>, what can you tell me about it?

assistant: 5-Hydroxy-8-methoxy-2,4-dimethyl-2,3,5a,9a-tetrahydrobenzo[g][1]benzofuran-6,9-dione is a natural product found in Fusarium solani and Fusarium with data available.
Molecule SMILES: COC(C(=O)C(O)C(C)O)C1Cc2cc3cc(OC4CC(OC5CC(O)C(OC)C(C)O5)C(OC(C)=O)C(C)O4)c(C)c(O)c3c(O)c2C(=O)C1OC1CC(OC2CC(OC3CC(C)(O)C(OC(C)=O)C(C)O3)C(O)C(C)O2)C(O)C(C)O1

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: Could you provide a description of this molecule <molecule_2d> ?

assistant: Chromomycin A3 is a glycosidic antineoplastic antibiotic isolated from the bacterium Streptomyces griseus.  Chromomycin A3 reversibly binds to guanine-cytosine (G-C) base pairs in the minor groove of DNA, thereby inhibiting RNA synthesis.  This agent is used as a fluorescent chromosome dye. (NCI04)
Molecule SMILES: COC(=O)C(C)=CC=CC1(C)OC(=O)C23CC=C(C(=O)OC)CCC2(OC(C)=O)C1CC3

system: You are a chemist. Now you are given a representation of a molecule. Please help me to understand the molecule.

user: <molecule_2d> The above is a compound. Could you please tell me something about it?

assistant: methyl (1R,7S,8S,9S)-7-acetyloxy-9-[(1E,3E)-5-methoxy-4-methyl-5-oxopenta-1,3-dienyl]-9-methyl-11-oxo-10-oxatricyclo[6.3.2.01,7]tridec-3-ene-4-carboxylate is a natural product found in Pseudolarix amabilis and Larix kaempferi with data available.