Model: potsu-potsu/bge-base-biomedical-modal-no-mrl-e4
Author: potsu-potsu
Pipeline: sentence-similarity
Library: sentence-transformers
Tags: sentence-transformers, safetensors, bert, sentence-similarity, feature-extraction, generated_from_trainer, dataset_size:4012, loss:MultipleNegativesRankingLoss, en, arxiv:1908.10084, arxiv:1705.00652, license:apache-2.0, model-index, text-embeddings-inference, endpoints_compatible, region:us
Card metadata: language: en
license: apache-2.0
tags: sentence-transformers, sentence-similarity, feature-extraction, generated_from_trainer, dataset_size:4012, loss:MultipleNegativesRankingLoss
widget: source_sentence: Do cephalopods use RNA editing less frequently than other species?
sentences: Extensive messenger RNA editing generates transcript and protein diversity in genes involved in neural excitability, as previously described, as well as in genes participating in a broad range of other cellular functions. , GV1001 is a 16-amino-acid vaccine peptide derived from the human telomerase reverse transcriptase sequence. It has been developed as a vaccine against various cancers., Using acetyl-specific K516 antibodies, we show that acetylation of endogenous S6K1 at this site is potently induced upon growth factor stimulation. We propose that K516 acetylation may serve to modulate important kinase-independent functions of S6K1 in response to growth factor signalling. Following mitogen stimulation, S6Ks interact with the p300 and p300/CBP-associated factor (PCAF) acetyltransferases. S6Ks can be acetylated by p300 and PCAF in vitro and S6K acetylation is detected in cells expressing p300, source_sentence: Can pets affect infant microbiomed?
sentences: Yes, exposure to household furry pets influences the gut microbiota of infants., Thiazovivin is a selective small molecule that directly targets Rho-associated kinase (ROCK) and increases expression of pluripotency factors.,  Here, we present evidence that the calcium/calmodulin-dependent protein kinase IV (CaMK4) is increased and required during Th17 cell differentiation. Inhibition of CaMK4 reduced Il17 transcription through decreased activation of the cAMP response element modulator a (CREM-a) and reduced activation of the AKT/mTOR pathway, which is known to enhance Th17 differentiation. CAMK4 knockdown and kinase-dead mutant inhibited crocin-mediated HO-1 expression, Nrf2 activation, and phosphorylation of Akt, indicating that HO-1 expression is mediated by CAMK4 and that Akt is a downstream mediator of CAMK4 in crocin signaling, source_sentence: In what proportion of children with heart failure has Enalapril been shown to be safe and effective?
sentences: 5-HT2A (5-hydroxytryptamine type 2a) receptor can be evaluated with the [18F]altanserin., In children with heart failure evidence of the effect of enalapril is empirical. Enalapril was clinically safe and effective in 50% to 80% of for children with cardiac failure secondary to congenital heart malformations before and after cardiac surgery,  impaired ventricular function , valvar regurgitation,  congestive cardiomyopathy,  , arterial hypertension, life-threatening arrhythmias coexisting with circulatory insufficiency.   
ACE inhibitors have shown a transient beneficial effect on heart failure due to anticancer drugs and possibly a beneficial effect in muscular dystrophy-associated cardiomyopathy, which deserves further studies., necroptosis
apoptosis  
pro-survival/inflammation NF-κB activation, source_sentence: How are SAHFS created?
sentences: In particular, up to 17% of neutrophil nuclei of healthy women exhibit a drumstick-shaped appendage that contains the inactive X chromosome., miR-1, miR-133, miR-208a, miR-206, miR-494, miR-146a, miR-222, miR-21, miR-221, miR-20a, miR-133a, miR-133b, miR-23, miR-107 and miR-181 are involved in exercise adaptation, Cellular senescence-associated heterochromatic foci (SAHFS) are a novel type of chromatin condensation involving alterations of linker histone H1 and linker DNA-binding proteins. SAHFS can be formed by a variety of cell types, but their mechanism of action remains unclear., source_sentence: What are the effects of the deletion of all three Pcdh clusters (tricluster deletion) in mice?
sentences: Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly. The vertebrate clustered protocadherin (Pcdh) cell surface proteins are encoded by three closely linked gene clusters (Pcdhα, Pcdhβ, and Pcdhγ). Although deletion of individual Pcdh clusters had subtle phenotypic consequences, the loss of all three clusters (tricluster deletion) led to a severe axonal arborization defect and loss of self-avoidance., The myocyte enhancer factor-2 (MEF2) proteins are MADS-box transcription factors that are essential for differentiation of all muscle lineages but their mechanisms of action remain largely undefined. MEF2C expression initiates cardiomyogenesis, resulting in the up-regulation of Brachyury T, bone morphogenetic protein-4, Nkx2-5, GATA-4, cardiac alpha-actin, and myosin heavy chain expression. Inactivation of the MEF2C gene causes cardiac developmental arrest and severe downregulation of a number of cardiac markers including atrial natriuretic factor (ANF). BMP-2, a regulator of cardiac development during embryogenesis, was shown to increase PI 3-kinase activity in cardiac precursor cells, resulting in increased expression of sarcomeric myosin heavy chain (MHC) and MEF-2A. Furthermore, expression of MEF-2A increased MHC expression in a PI 3-kinase-dependent manner. Other studies showed that Gli2 and MEF2C proteins form a complex, capable of synergizing on cardiomyogenesis-related promoters. Dominant interference of calcineurin/mAKAP binding blunts the increase in MEF2 transcriptional activity seen during myoblast differentiation, as well as the expression of endogenous MEF2-target genes. These findings show that MEF-2 can direct early stages of cell differentiation into a cardiomyogenic pathway., Investigators proposed that there have been three extended periods in the evolution of gene regulatory elements. Early vertebrate evolution was characterized by regulatory gains near transcription factors and developmental genes, but this trend was replaced by innovations near extracellular signaling genes, and then innovations near posttranslational protein modifiers.
pipeline_tag: sentence-similarity
library_name: sentence-transformers
metrics: cosine_accuracy@10, cosine_accuracy@15, cosine_accuracy@20, cosine_accuracy@25, cosine_accuracy@30, cosine_precision@10, cosine_precision@15, cosine_precision@20, cosine_precision@25, cosine_precision@30, cosine_recall@10, cosine_recall@15, cosine_recall@20, cosine_recall@25, cosine_recall@30, cosine_ndcg@10, cosine_ndcg@20, cosine_ndcg@30, cosine_mrr@10, cosine_mrr@20, cosine_mrr@30, cosine_map@100
model-index: name: MedEmbed Biomedical MRL
results: task: type: information-retrieval
name: Information Retrieval
dataset: name: bge base
type: bge-base
metrics: type: cosine_accuracy@10
value: 0.925035360678925
name: Cosine Accuracy@10
verified: no, type: cosine_accuracy@15
value: 0.9306930693069307
name: Cosine Accuracy@15
verified: no, type: cosine_accuracy@20
value: 0.9363507779349364
name: Cosine Accuracy@20
verified: no, type: cosine_accuracy@25
value: 0.9405940594059405
name: Cosine Accuracy@25
verified: no, type: cosine_accuracy@30
value: 0.9405940594059405
name: Cosine Accuracy@30
verified: no, type: cosine_precision@10
value: 0.4007072135785007
name: Cosine Precision@10
verified: no, type: cosine_precision@15
value: 0.3334276284771335
name: Cosine Precision@15
verified: no, type: cosine_precision@20
value: 0.2821074964639321
name: Cosine Precision@20
verified: no, type: cosine_precision@25
value: 0.2431117397454031
name: Cosine Precision@25
verified: no, type: cosine_precision@30
value: 0.21244695898161242
name: Cosine Precision@30
verified: no, type: cosine_recall@10
value: 0.6092762929036104
name: Cosine Recall@10
verified: no, type: cosine_recall@15
value: 0.6809463217262091
name: Cosine Recall@15
verified: no, type: cosine_recall@20
value: 0.7244639993784594
name: Cosine Recall@20
verified: no, type: cosine_recall@25
value: 0.7517140870809429
name: Cosine Recall@25
verified: no, type: cosine_recall@30
value: 0.768039975831348
name: Cosine Recall@30
verified: no, type: cosine_ndcg@10
value: 0.6976869695501996
name: Cosine Ndcg@10
verified: no, type: cosine_ndcg@20
value: 0.7122158984887877
name: Cosine Ndcg@20
verified: no, type: cosine_ndcg@30
value: 0.7225075023947289
name: Cosine Ndcg@30
verified: no, type: cosine_mrr@10
value: 0.8179823084349251
name: Cosine Mrr@10
verified: no, type: cosine_mrr@20
value: 0.8186825051368471
name: Cosine Mrr@20
verified: no, type: cosine_mrr@30
value: 0.8188648711995403
name: Cosine Mrr@30
verified: no, type: cosine_map@100
value: 0.6279010939230897
name: Cosine Map@100
verified: no
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Created: 2025-06-10 13:08:43