Model: FareedKhan/flax-sentence-embeddings_all_datasets_v4_MiniLM-L6_FareedKhan_prime_synthetic_data_2k_10_64
Author: FareedKhan
Pipeline: sentence-similarity
Library: sentence-transformers
Tags: sentence-transformers, safetensors, bert, sentence-similarity, feature-extraction, generated_from_trainer, dataset_size:1814, loss:MatryoshkaLoss, loss:MultipleNegativesRankingLoss, arxiv:1908.10084, arxiv:2205.13147, arxiv:1705.00652, base_model:flax-sentence-embeddings/all_datasets_v4_MiniLM-L6, base_model:finetune:flax-sentence-embeddings/all_datasets_v4_MiniLM-L6, model-index, text-embeddings-inference, endpoints_compatible, region:us
Base models (finetune): id: flax-sentence-embeddings/all_datasets_v4_MiniLM-L6
Card metadata: base_model: flax-sentence-embeddings/all_datasets_v4_MiniLM-L6
library_name: sentence-transformers
metrics: cosine_accuracy@1, cosine_accuracy@3, cosine_accuracy@5, cosine_accuracy@10, cosine_precision@1, cosine_precision@3, cosine_precision@5, cosine_precision@10, cosine_recall@1, cosine_recall@3, cosine_recall@5, cosine_recall@10, cosine_ndcg@10, cosine_mrr@10, cosine_map@100
pipeline_tag: sentence-similarity
tags: sentence-transformers, sentence-similarity, feature-extraction, generated_from_trainer, dataset_size:1814, loss:MatryoshkaLoss, loss:MultipleNegativesRankingLoss
widget: source_sentence: 
The list you've provided contains a variety of medications, including antidepressants, antihistamines, anxiolytics, and more. Here's a breakdown by category:

### Antidepressants
- **Amphetamine**
- **Cevimeline**
- **Esmolol**
- **Bortezomib**
- **
sentences: Which body parts are associated with the expression of genes or proteins that impact the transporter responsible for the movement of Cycloserine?, Identify genes or proteins that interact with a protein threonine kinase, participate in the mitotic centrosome proteins and complexes recruitment pathway, and engage in protein-protein interactions with CCT2., Which medication is effective against simple Plasmodium falciparum infections and functions by engaging with genes or proteins that interact with the minor groove of DNA rich in adenine and thymine?, source_sentence: 
RNASE6, also known by aliases such as RAD1, RNS6, and RNasek6, functions as a member of the ribonuclease A superfamily. Specifically identified via the NCBI gene/protein database, this protein is related to the antimicrobial peptides pathway, showcasing broad-spectrum antimicrobial activity against pathogenic bacteria in the urinary tract. The provided gene summary emphasizes its role in the urinary tract, highlighting its enzymatic function and broad antimicrobial capability.

With a genomic position spanning from 20781268 to 20782467 on chromosome 14, the RNASE6 gene encodes a protein named ribonuclease A family member k6. The protein's interactions with cellular and molecular functions are integral to its role, including its interaction with molecular functions like ribonuclease activity and endonuclease activity, as well as its involvement in nucleic acid binding.

RNASE6's involvement in biological
sentences: Identify genes or proteins linked to encephalopathy that are involved in the Antimicrobial peptides pathway and have interactions with molecular functions associated with ribonuclease activity., Identify genes or proteins that exhibit interaction with COMMD1 and share an associated phenotype or effect., What medical conditions are associated with severe combined immunodeficiency and also cause muscle pain and weakness?, source_sentence: 

The gene in question is likely involved in multiple biological processes, including:

1. **Transmembrane transport**: It facilitates the entry of substances into or out of a cell through the cell membrane, which is crucial for maintaining cellular homeostasis and responding to environmental stimuli. This includes organic anion and carboxylic acid transport.

2. **ABC-family proteins mediated transport**: ABC (or ATP-binding cassette) proteins are responsible for a variety of transport processes, such as drug efflux, nutrient uptake, and xenobiotic detoxification.

3. **Response to drug**: It likely plays a role in how cells interact with and respond to medication or other foreign substances they encounter. This is important in pharmacology and toxicology.

4. **Regulation of chloride transport**: Chloride ions are crucial for maintaining electrolyte balance and are involved in multiple physiological processes. This gene likely helps regulate their transport in and out of the cell.

5. **Export across plasma membrane**: It is part of pathways that help in the removal of substances from the cell, such as efflux of drug metabolites or other waste products.

### Expression Contexts:

- **Present**: This gene is expressed in many parts of the body, indicating a broad role. It shows presence in tissues like the islet of Langerhans (involved in insulin regulation), zones of the skin, and various brain regions. It's also active in organs such as the heart, kidney, and lungs, and in the digestive tract, including the stomach, esophagus, and intestines.

- **Absent or Reduced**: The gene's expression is notably absent or less pronounced in tissues like the nasal cavity epithelium, suggesting it may not play a significant role in this specific tissue type.

The gene's multifaceted expression and roles suggest a key function in biological activities related to:
- **Chemical
sentences: Could you supply a selection of medications used to treat acute myeloid leukemia with minimal differentiation that have a potential side effect of arrhythmias and work by intercalating DNA and inhibiting topoisomerase II?, Is the ABCB1 protein responsible for the translocation of pharmaceuticals that exhibit synergistic effects when combined with ferric ions?, What potential conditions could I have that are associated with oophoritis and involve ovarian complications?, source_sentence: 

The list you provided seems to be a collection of various chemical compounds, pharmaceuticals, and their synonyms. They span across various categories:

1. **Pharmaceuticals & Synthetic Drug Analogs**:
    - **Antibiotics** (Ceftazidime, Azithromycin, Ceftodipen, etc.)
    - **Analgesics** (Fentanyl, Ketorolac, etc.)
    - **Cephalosporins** (Ceftazidime, Ceftazidime-avibactam, etc.)
    - **Blood Thinners/Synthetic Anticoagulants** (Enoxaparin, Edoxaban, Rivaroxaban, etc.)
    - **Analgesic/Aspirin Analogues** (Mefenamic Acid, Indometacin, etc.)
    - **Adrenergic Agonists** (Isoprenaline, Dopamine, etc.)
    - **Antiviral Drugs** (Adefovir, Idelalisib, etc.)
    - **Antibiotic Resistance Modifiers** (Sulbactam, Tazobactam, etc.)
    - **Calcium Channel Blockers** (Verapamil, Nicardipine, etc.)
    - **Nutraceuticals/Herbal Extracts** (Ginsenoside, Phloretin, etc.)
   
2. **Diagnostic Agents**:
    - **Radiopharmaceuticals** (F-Fluorodeoxyglucose, Ga-68 DOTATOC, etc.)
    - **MRI Contrasts** (Gadolinium chelates, etc.)
    - **CT Contrast Agents** (Iodinated contrast agents, etc.)
   
3. **Ingredients in Drugs**:
    - **Excipients** (Hydroxypropylmethylcellulose, Lactose, etc.)
    - **Antifungal Drugs** (Itraconazole, Terconazole, etc.)
    - **Anticoagulants** (Warfarin, Heparin, etc.)
        
This list represents a broad spectrum of modern medicine, from antibiotics to chemicals used in diagnostic imaging techniques, and from dietary supplements to drug excipients. Each compound typically serves a specific therapeutic purpose in the human body.
sentences: Which investigational compound in solid form that aims at altering membrane lipids, specifically phospholipids and glycerophospholipids, has the additional property of interacting with genes or proteins involved in ubiquitin-specific protease binding?, Could you provide a list of medications that exhibit synergistic effects when used in combination with Choline magnesium trisalicylate to treat the same condition and that also selectively target COX-2 enzymes to alleviate inflammation?, Identify pathways associated with the interaction between TNFs and their physiological receptors that concurrently influence the same gene or protein., source_sentence: 

Diarrhea, a condition characterized by the passage of loose, watery, and often more than five times a day, is a common ailment affecting individuals of all ages. It is typically acute when it lasts for a few days to a week or recurrent when it persists for more than four weeks. While acute diarrhea often resolves on its own and is usually not a cause for concern, recurrent or chronic forms require medical attention due to the risk of dehydration and nutrient deficiencies. 

### Causes

Diarrhea can be caused by various factors, including:

1. **Viral
sentences: Could you describe the specific effects or phenotypes associated with acute hydrops in patients with the subtype of keratoconus?, What is the disease associated with the CPT2 gene that causes severe fasting intolerance leading to metabolic disturbances such as hypoketotic hypoglycemia, risking coma and seizures, and can lead to hepatic encephalopathy and liver failure, and also affects the heart and skeletal muscles, increasing the risk of potentially fatal cardiac arrhythmias?, Could you assist in identifying a condition linked to congenital secretory diarrhea, similar to intractable diarrhea of infancy, given my symptoms of persistent, salty watery diarrhea, hyponatremia, abnormal body pH, and reliance on parenteral nutrition due to chronic dehydration?
model-index: name: SentenceTransformer based on flax-sentence-embeddings/all_datasets_v4_MiniLM-L6
results: task: type: information-retrieval
name: Information Retrieval
dataset: name: dim 384
type: dim_384
metrics: type: cosine_accuracy@1
value: 0.3613861386138614
name: Cosine Accuracy@1
verified: no, type: cosine_accuracy@3
value: 0.38613861386138615
name: Cosine Accuracy@3
verified: no, type: cosine_accuracy@5
value: 0.42574257425742573
name: Cosine Accuracy@5
verified: no, type: cosine_accuracy@10
value: 0.46534653465346537
name: Cosine Accuracy@10
verified: no, type: cosine_precision@1
value: 0.3613861386138614
name: Cosine Precision@1
verified: no, type: cosine_precision@3
value: 0.12871287128712872
name: Cosine Precision@3
verified: no, type: cosine_precision@5
value: 0.08514851485148513
name: Cosine Precision@5
verified: no, type: cosine_precision@10
value: 0.04653465346534653
name: Cosine Precision@10
verified: no, type: cosine_recall@1
value: 0.3613861386138614
name: Cosine Recall@1
verified: no, type: cosine_recall@3
value: 0.38613861386138615
name: Cosine Recall@3
verified: no, type: cosine_recall@5
value: 0.42574257425742573
name: Cosine Recall@5
verified: no, type: cosine_recall@10
value: 0.46534653465346537
name: Cosine Recall@10
verified: no, type: cosine_ndcg@10
value: 0.4070317030609663
name: Cosine Ndcg@10
verified: no, type: cosine_mrr@10
value: 0.3890519409083766
name: Cosine Mrr@10
verified: no, type: cosine_map@100
value: 0.3959688055946467
name: Cosine Map@100
verified: no
Likes: 0 | All-time downloads: 116
Created: 2024-09-30 11:22:10