Model: SaborDay/Phi2_RCT1M-ft-heading
Author: SaborDay
Pipeline: text-generation
Library: transformers
Tags: transformers, safetensors, phi, text-generation, medical, pubmed, clinical trials, scientific literature, custom_code, en, arxiv:1710.06071, arxiv:2106.09685, arxiv:2309.05463, base_model:microsoft/phi-2, base_model:finetune:microsoft/phi-2, text-generation-inference, endpoints_compatible, region:us
Base models (finetune): id: microsoft/phi-2
Card metadata: library_name: transformers
language: en
base_model: microsoft/phi-2
pipeline_tag: text-generation
tags: medical, pubmed, clinical trials, scientific literature
widget: '###Unstruct:
Kawasaki disease (KD) is a systemic vasculitis that causes abnormalities in the coronary arteries. Interleukin (IL)-41 is a novel immunoregulatory cytokine involved in the pathogenesis of some inflammatory and immune-related diseases. However, the role of IL-41 in KD is unclear. The purpose of this study was to detect the expression of IL-41 in the plasma of children with KD and its relationship with the disease.
A total of 44 children with KD and 37 healthy controls (HC) were recruited for this study. Plasma concentrations of IL-41 were determined by ELISA. Correlations between plasma IL-41 levels and KD-related clinical parameters were analyzed by Pearson correlation and multivariate linear regression analysis. Receiver operating characteristic curve analysis was used to assess the clinical value of IL-41 in the diagnosis of KD.
Our results showed that plasma IL-41 levels were significantly elevated in children with KD compared with HC. Correlation analysis demonstrated that IL-41 levels were positively correlated with D-dimer and N-terminal pro-B-type natriuretic peptide, and negatively correlated with IgM, mean corpuscular hemoglobin concentration, total protein, albumin and pre-albumin. Multivariable linear regression analysis revealed that IgM and mean corpuscular hemoglobin concentrations were associated with IL-41. Receiver operating characteristic curve analysis showed that the area under the curve of IL-41 was 0.7101, with IL-41 providing 88.64 % sensitivity and 54.05 % specificity.
Our study indicated that plasma IL-41 levels in children with KD were significantly higher than those in HC, and may provide a potential diagnostic biomarker for KD.
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Created: 2024-03-29 08:42:33