Model: potsu-potsu/medembed-base-biomedical-matryoshka
Author: potsu-potsu
Pipeline: sentence-similarity
Library: sentence-transformers
Tags: sentence-transformers, safetensors, bert, sentence-similarity, feature-extraction, generated_from_trainer, dataset_size:4012, loss:MatryoshkaLoss, loss:MultipleNegativesRankingLoss, en, arxiv:1908.10084, arxiv:2205.13147, arxiv:1705.00652, license:apache-2.0, model-index, text-embeddings-inference, endpoints_compatible, region:us
Card metadata: language: en
license: apache-2.0
tags: sentence-transformers, sentence-similarity, feature-extraction, generated_from_trainer, dataset_size:4012, loss:MatryoshkaLoss, loss:MultipleNegativesRankingLoss
widget: source_sentence: Do cephalopods use RNA editing less frequently than other species?
sentences: Extensive messenger RNA editing generates transcript and protein diversity in genes involved in neural excitability, as previously described, as well as in genes participating in a broad range of other cellular functions. , GV1001 is a 16-amino-acid vaccine peptide derived from the human telomerase reverse transcriptase sequence. It has been developed as a vaccine against various cancers., Using acetyl-specific K516 antibodies, we show that acetylation of endogenous S6K1 at this site is potently induced upon growth factor stimulation. We propose that K516 acetylation may serve to modulate important kinase-independent functions of S6K1 in response to growth factor signalling. Following mitogen stimulation, S6Ks interact with the p300 and p300/CBP-associated factor (PCAF) acetyltransferases. S6Ks can be acetylated by p300 and PCAF in vitro and S6K acetylation is detected in cells expressing p300, source_sentence: Can pets affect infant microbiomed?
sentences: Yes, exposure to household furry pets influences the gut microbiota of infants., Thiazovivin is a selective small molecule that directly targets Rho-associated kinase (ROCK) and increases expression of pluripotency factors.,  Here, we present evidence that the calcium/calmodulin-dependent protein kinase IV (CaMK4) is increased and required during Th17 cell differentiation. Inhibition of CaMK4 reduced Il17 transcription through decreased activation of the cAMP response element modulator a (CREM-a) and reduced activation of the AKT/mTOR pathway, which is known to enhance Th17 differentiation. CAMK4 knockdown and kinase-dead mutant inhibited crocin-mediated HO-1 expression, Nrf2 activation, and phosphorylation of Akt, indicating that HO-1 expression is mediated by CAMK4 and that Akt is a downstream mediator of CAMK4 in crocin signaling, source_sentence: In what proportion of children with heart failure has Enalapril been shown to be safe and effective?
sentences: 5-HT2A (5-hydroxytryptamine type 2a) receptor can be evaluated with the [18F]altanserin., In children with heart failure evidence of the effect of enalapril is empirical. Enalapril was clinically safe and effective in 50% to 80% of for children with cardiac failure secondary to congenital heart malformations before and after cardiac surgery,  impaired ventricular function , valvar regurgitation,  congestive cardiomyopathy,  , arterial hypertension, life-threatening arrhythmias coexisting with circulatory insufficiency.   
ACE inhibitors have shown a transient beneficial effect on heart failure due to anticancer drugs and possibly a beneficial effect in muscular dystrophy-associated cardiomyopathy, which deserves further studies., necroptosis
apoptosis  
pro-survival/inflammation NF-κB activation, source_sentence: How are SAHFS created?
sentences: In particular, up to 17% of neutrophil nuclei of healthy women exhibit a drumstick-shaped appendage that contains the inactive X chromosome., miR-1, miR-133, miR-208a, miR-206, miR-494, miR-146a, miR-222, miR-21, miR-221, miR-20a, miR-133a, miR-133b, miR-23, miR-107 and miR-181 are involved in exercise adaptation, Cellular senescence-associated heterochromatic foci (SAHFS) are a novel type of chromatin condensation involving alterations of linker histone H1 and linker DNA-binding proteins. SAHFS can be formed by a variety of cell types, but their mechanism of action remains unclear., source_sentence: What are the effects of the deletion of all three Pcdh clusters (tricluster deletion) in mice?
sentences: Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly. The vertebrate clustered protocadherin (Pcdh) cell surface proteins are encoded by three closely linked gene clusters (Pcdhα, Pcdhβ, and Pcdhγ). Although deletion of individual Pcdh clusters had subtle phenotypic consequences, the loss of all three clusters (tricluster deletion) led to a severe axonal arborization defect and loss of self-avoidance., The myocyte enhancer factor-2 (MEF2) proteins are MADS-box transcription factors that are essential for differentiation of all muscle lineages but their mechanisms of action remain largely undefined. MEF2C expression initiates cardiomyogenesis, resulting in the up-regulation of Brachyury T, bone morphogenetic protein-4, Nkx2-5, GATA-4, cardiac alpha-actin, and myosin heavy chain expression. Inactivation of the MEF2C gene causes cardiac developmental arrest and severe downregulation of a number of cardiac markers including atrial natriuretic factor (ANF). BMP-2, a regulator of cardiac development during embryogenesis, was shown to increase PI 3-kinase activity in cardiac precursor cells, resulting in increased expression of sarcomeric myosin heavy chain (MHC) and MEF-2A. Furthermore, expression of MEF-2A increased MHC expression in a PI 3-kinase-dependent manner. Other studies showed that Gli2 and MEF2C proteins form a complex, capable of synergizing on cardiomyogenesis-related promoters. Dominant interference of calcineurin/mAKAP binding blunts the increase in MEF2 transcriptional activity seen during myoblast differentiation, as well as the expression of endogenous MEF2-target genes. These findings show that MEF-2 can direct early stages of cell differentiation into a cardiomyogenic pathway., Investigators proposed that there have been three extended periods in the evolution of gene regulatory elements. Early vertebrate evolution was characterized by regulatory gains near transcription factors and developmental genes, but this trend was replaced by innovations near extracellular signaling genes, and then innovations near posttranslational protein modifiers.
pipeline_tag: sentence-similarity
library_name: sentence-transformers
metrics: cosine_accuracy@1, cosine_accuracy@3, cosine_accuracy@5, cosine_accuracy@10, cosine_precision@1, cosine_precision@3, cosine_precision@5, cosine_precision@10, cosine_recall@1, cosine_recall@3, cosine_recall@5, cosine_recall@10, cosine_ndcg@10, cosine_mrr@10, cosine_map@100
model-index: name: MedEmbed Biomedical MRL
results: task: type: information-retrieval
name: Information Retrieval
dataset: name: dim 768
type: dim_768
metrics: type: cosine_accuracy@1
value: 0.7425742574257426
name: Cosine Accuracy@1
verified: no, type: cosine_accuracy@3
value: 0.8557284299858557
name: Cosine Accuracy@3
verified: no, type: cosine_accuracy@5
value: 0.8939179632248939
name: Cosine Accuracy@5
verified: no, type: cosine_accuracy@10
value: 0.9165487977369166
name: Cosine Accuracy@10
verified: no, type: cosine_precision@1
value: 0.7425742574257426
name: Cosine Precision@1
verified: no, type: cosine_precision@3
value: 0.5912305516265912
name: Cosine Precision@3
verified: no, type: cosine_precision@5
value: 0.5154172560113154
name: Cosine Precision@5
verified: no, type: cosine_precision@10
value: 0.3953323903818953
name: Cosine Precision@10
verified: no, type: cosine_recall@1
value: 0.23041125354029493
name: Cosine Recall@1
verified: no, type: cosine_recall@3
value: 0.39197309223977045
name: Cosine Recall@3
verified: no, type: cosine_recall@5
value: 0.48381876775694876
name: Cosine Recall@5
verified: no, type: cosine_recall@10
value: 0.6032146977680277
name: Cosine Recall@10
verified: no, type: cosine_ndcg@10
value: 0.6884780390085676
name: Cosine Ndcg@10
verified: no, type: cosine_mrr@10
value: 0.805940594059406
name: Cosine Mrr@10
verified: no, type: cosine_map@100
value: 0.6194687207790284
name: Cosine Map@100
verified: no, task: type: information-retrieval
name: Information Retrieval
dataset: name: dim 512
type: dim_512
metrics: type: cosine_accuracy@1
value: 0.7411598302687411
name: Cosine Accuracy@1
verified: no, type: cosine_accuracy@3
value: 0.8557284299858557
name: Cosine Accuracy@3
verified: no, type: cosine_accuracy@5
value: 0.8854314002828855
name: Cosine Accuracy@5
verified: no, type: cosine_accuracy@10
value: 0.9137199434229137
name: Cosine Accuracy@10
verified: no, type: cosine_precision@1
value: 0.7411598302687411
name: Cosine Precision@1
verified: no, type: cosine_precision@3
value: 0.5935879302215936
name: Cosine Precision@3
verified: no, type: cosine_precision@5
value: 0.5103253182461104
name: Cosine Precision@5
verified: no, type: cosine_precision@10
value: 0.3927864214992928
name: Cosine Precision@10
verified: no, type: cosine_recall@1
value: 0.2294188374773112
name: Cosine Recall@1
verified: no, type: cosine_recall@3
value: 0.39235334373726566
name: Cosine Recall@3
verified: no, type: cosine_recall@5
value: 0.4769516683280722
name: Cosine Recall@5
verified: no, type: cosine_recall@10
value: 0.5984883868092931
name: Cosine Recall@10
verified: no, type: cosine_ndcg@10
value: 0.6838381438006835
name: Cosine Ndcg@10
verified: no, type: cosine_mrr@10
value: 0.8031308232864104
name: Cosine Mrr@10
verified: no, type: cosine_map@100
value: 0.613444475710047
name: Cosine Map@100
verified: no, task: type: information-retrieval
name: Information Retrieval
dataset: name: dim 256
type: dim_256
metrics: type: cosine_accuracy@1
value: 0.7284299858557284
name: Cosine Accuracy@1
verified: no, type: cosine_accuracy@3
value: 0.8415841584158416
name: Cosine Accuracy@3
verified: no, type: cosine_accuracy@5
value: 0.8868458274398868
name: Cosine Accuracy@5
verified: no, type: cosine_accuracy@10
value: 0.9094766619519095
name: Cosine Accuracy@10
verified: no, type: cosine_precision@1
value: 0.7284299858557284
name: Cosine Precision@1
verified: no, type: cosine_precision@3
value: 0.5775577557755776
name: Cosine Precision@3
verified: no, type: cosine_precision@5
value: 0.4998585572842999
name: Cosine Precision@5
verified: no, type: cosine_precision@10
value: 0.3848656294200849
name: Cosine Precision@10
verified: no, type: cosine_recall@1
value: 0.22592452085342074
name: Cosine Recall@1
verified: no, type: cosine_recall@3
value: 0.3776018169440626
name: Cosine Recall@3
verified: no, type: cosine_recall@5
value: 0.4680836435267496
name: Cosine Recall@5
verified: no, type: cosine_recall@10
value: 0.583206594855527
name: Cosine Recall@10
verified: no, type: cosine_ndcg@10
value: 0.668556227973642
name: Cosine Ndcg@10
verified: no, type: cosine_mrr@10
value: 0.791215397049909
name: Cosine Mrr@10
verified: no, type: cosine_map@100
value: 0.5943191357970502
name: Cosine Map@100
verified: no, task: type: information-retrieval
name: Information Retrieval
dataset: name: dim 128
type: dim_128
metrics: type: cosine_accuracy@1
value: 0.7043847241867044
name: Cosine Accuracy@1
verified: no, type: cosine_accuracy@3
value: 0.8118811881188119
name: Cosine Accuracy@3
verified: no, type: cosine_accuracy@5
value: 0.8528995756718529
name: Cosine Accuracy@5
verified: no, type: cosine_accuracy@10
value: 0.884016973125884
name: Cosine Accuracy@10
verified: no, type: cosine_precision@1
value: 0.7043847241867044
name: Cosine Precision@1
verified: no, type: cosine_precision@3
value: 0.5525695426685525
name: Cosine Precision@3
verified: no, type: cosine_precision@5
value: 0.4746817538896747
name: Cosine Precision@5
verified: no, type: cosine_precision@10
value: 0.36322489391796325
name: Cosine Precision@10
verified: no, type: cosine_recall@1
value: 0.2159701206514958
name: Cosine Recall@1
verified: no, type: cosine_recall@3
value: 0.3568957420252175
name: Cosine Recall@3
verified: no, type: cosine_recall@5
value: 0.43488680368745253
name: Cosine Recall@5
verified: no, type: cosine_recall@10
value: 0.5439149848201016
name: Cosine Recall@10
verified: no, type: cosine_ndcg@10
value: 0.6330673368410006
name: Cosine Ndcg@10
verified: no, type: cosine_mrr@10
value: 0.7664668507667095
name: Cosine Mrr@10
verified: no, type: cosine_map@100
value: 0.5528819637907428
name: Cosine Map@100
verified: no, task: type: information-retrieval
name: Information Retrieval
dataset: name: dim 64
type: dim_64
metrics: type: cosine_accuracy@1
value: 0.628005657708628
name: Cosine Accuracy@1
verified: no, type: cosine_accuracy@3
value: 0.7567185289957568
name: Cosine Accuracy@3
verified: no, type: cosine_accuracy@5
value: 0.801980198019802
name: Cosine Accuracy@5
verified: no, type: cosine_accuracy@10
value: 0.8444130127298444
name: Cosine Accuracy@10
verified: no, type: cosine_precision@1
value: 0.628005657708628
name: Cosine Precision@1
verified: no, type: cosine_precision@3
value: 0.503064592173503
name: Cosine Precision@3
verified: no, type: cosine_precision@5
value: 0.4251768033946252
name: Cosine Precision@5
verified: no, type: cosine_precision@10
value: 0.3265912305516266
name: Cosine Precision@10
verified: no, type: cosine_recall@1
value: 0.19258662387092207
name: Cosine Recall@1
verified: no, type: cosine_recall@3
value: 0.31972741276523736
name: Cosine Recall@3
verified: no, type: cosine_recall@5
value: 0.3823691177395503
name: Cosine Recall@5
verified: no, type: cosine_recall@10
value: 0.4871450265801822
name: Cosine Recall@10
verified: no, type: cosine_ndcg@10
value: 0.5674192624623249
name: Cosine Ndcg@10
verified: no, type: cosine_mrr@10
value: 0.699987090545789
name: Cosine Mrr@10
verified: no, type: cosine_map@100
value: 0.48061564724851846
name: Cosine Map@100
verified: no
Likes: 0 | All-time downloads: 195
Created: 2025-06-09 21:54:06