Model: RikoteMaster/MNLP_M2_document_encoder
Author: RikoteMaster
Pipeline: sentence-similarity
Library: sentence-transformers
Tags: sentence-transformers, safetensors, bert, sentence-similarity, feature-extraction, generated_from_trainer, dataset_size:57126, loss:MultipleNegativesRankingLoss, arxiv:1908.10084, arxiv:1705.00652, base_model:sentence-transformers/all-MiniLM-L6-v2, base_model:finetune:sentence-transformers/all-MiniLM-L6-v2, text-embeddings-inference, endpoints_compatible, region:us
Base models (finetune): id: sentence-transformers/all-MiniLM-L6-v2
Card metadata: tags: sentence-transformers, sentence-similarity, feature-extraction, generated_from_trainer, dataset_size:57126, loss:MultipleNegativesRankingLoss
base_model: sentence-transformers/all-MiniLM-L6-v2
widget: source_sentence: ##inemia a the the upper limit of normal concentra - b success was defined or at least success menstrual cycles without of cycle. the most from the trial were dizziness, reproduced, comparison bromocriptine the hyperpro n j med ; 904. )
sentences: the yearly inci - dence of symptomatic gallstones is about 1 %. cardiac effects include sinus bradycardia ( 25 % ) and conduction disturbances ( 10 % ). pain at the site of injection is common, especially with the long - acting octreotide suspension. vitamin b 12 deficiency may occur with long - term use of octreotide. a long - acting formulation of lanreotide, another octapeptide somatostatin analog, was approved by the fda in 2007 for treat - ment of acromegaly. lanreotide appears to have effects comparable to those of octreotide on reducing gh levels and normalizing igf - i concentrations. pegvisomant pegvisomant is a gh receptor antagonist used to treat acromegaly. it is the polyethylene glycol ( peg ) derivative of a mutant gh, b2036. like native gh, pegvisomant has two gh receptor bind - ing sites. however, one of the pegvisomant gh receptor binding sites has increased affinity for the gh receptor, whereas its second gh receptor binding site has reduced affinity. this differential receptor affinity allows the initial step ( gh receptor dime, ##inemia and anovulation. a : the dotted line indicates the upper limit of normal serum prolactin concentra - tions. b : complete success was defined as pregnancy or at least two consecutive menses with evidence of ovulation at least once. partial success was two menstrual cycles without evidence of ovulation or just one ovulatory cycle. the most common reasons for withdrawal from the trial were nausea, headache, dizziness, abdominal pain, and fatigue. ( modified and reproduced, with permission, from webster j et al : a comparison of cabergoline and bromocriptine in the treatment of hyperpro - lactinemic amenorrhea. n engl j med 1994 ; 331 : 904. ), compounds are shown in figure 38 – 5. the thiocarbamide group is essential for antithyroid activity. pharmacokinetics methimazole is completely absorbed but at variable rates. it is readily accumulated by the thyroid gland and has a volume of distribution similar to that of propylthiouracil. excretion is slower than with propylthiouracil ; 65 – 70 % of a dose is recovered in the urine in 48 hours. in contrast, propylthiouracil is rapidly absorbed, reaching peak serum levels after 1 hour. the bioavailability of 50 – 80 % may be due to incomplete absorption or a large first - pass effect in the liver. the volume of distribution approximates total body water with accumulation in the thyroid gland. most of an ingested dose of propylthiouracil is excreted by the kidney as the inactive glucuronide within 24 hours. the short plasma half - life of these agents ( 1. 5 hours for propyl - thiouracil and 6 hours for methimazole ) has little influence on the duration of the antithyroid action or the dosing interval because both agents are accumulated by the thyroid gland. for propyl -, source_sentence: ##sis. serious hypertension, diabetes. disorder surgical irradiation of the pituitary tumor, or tion of both adrenals. patients large of cortisol during and doses to mg soluble hydrocortisone as - ous intravenous day of surgery. the dose reduced replacement levels, reduction in produce symptoms, including fever and if adrenalectomy - term main - tenance that outlined for c. primary chrousos syndrome — this or usually mutations the glucocorticoid - tor attempt to for hypo pituitary ) axis hyperfunctioning
sentences: ##sis. other serious disturbances include mental disorders, hypertension, and diabetes. this disorder is treated by surgical removal of the tumor produc - ing acth or cortisol, irradiation of the pituitary tumor, or resec - tion of one or both adrenals. these patients must receive large doses of cortisol during and after the surgical procedure. doses of up to 300 mg of soluble hydrocortisone may be given as a continu - ous intravenous infusion on the day of surgery. the dose must be reduced slowly to normal replacement levels, since rapid reduction in dose may produce withdrawal symptoms, including fever and joint pain. if adrenalectomy has been performed, long - term main - tenance is similar to that outlined above for adrenal insufficiency. c. primary generalized glucocorticoid resistance ( chrousos ) syndrome — this rare sporadic or familial genetic condition is usually due to inactivating mutations of the glucocorticoid recep - tor gene. in its attempt to compensate for the defect, the hypo - thalamic - pituitary - adrenal ( hpa ) axis is hyperfunctioning, oral : 200, 220, 250, 375, 500 mg tablets ; 375, 550 mg controlled - release tablets ; 375, 500 mg delayed - release tablets ; 125 mg / 5 ml suspension oxaprozin ( generic, daypro ) oral : 600 mg tablets, capsules piroxicam ( generic, feldene ) oral : 10, 20 mg capsules salsalate, salicylsalicylic acid ( generic, disalcid ) oral : 500, 750 mg tablets ; 500 mg capsules sodium salicylate ( generic ) oral : 325, 650 mg enteric - coated tablets sodium thiosalicylate ( generic, rexolate ) parenteral : 50 mg / ml for im injection sulindac ( generic, clinoril ) oral : 150, 200 mg tablets suprofen ( profenal ) topical : 1 % ophthalmic solution tolmetin ( generic, tolectin ) oral : 200, 600 mg tablets ; 400 mg capsules disease - modifying antirheumatic drugs abatacept ( orencia ) parenteral : 250 mg / vial lyophilized, for reconstitution for iv injection adalimumab ( humira ) parenteral : 40 mg /, a half - life of about 10 hours. lutropin has only been approved for use in combination with follitropin alfa for stimulation of follicular development in infertile women with profound lh deficiency. it has not been approved for use with the other preparations of fsh nor for simulating the endogenous lh surge that is needed to complete follicular development and pre - cipitate ovulation. d. human chorionic gonadotropin hcg is produced by the human placenta and excreted into the urine, whence it can be extracted and purified. it is a glycoprotein consisting of a 92 - amino - acid α chain virtually identical to that of fsh, lh, and tsh, and a β chain of 145 amino acids that resembles that of lh except for the presence of a carboxyl terminal sequence of 30 amino acids not present in lh. choriogonadotropin alfa ( rhcg ) is a recombinant form of hcg. because of its greater consistency in biologic activity, rhcg is packaged and dosed on the basis of weight rather than units of activity. all of the other gonadotropins, source_sentence: five origin. action is inhibits activation of ( chapter a has an ( ), produced cd28 on cell or on apc, leading - abatacept which contains the - 4 ) 86, inhibiting to pharmacokinetics abatacept infusion “ ” ( day 4 monthly infusions. is weight patients weighing less than kg mg, 100 receiving 750 and more than 100 kg 1000 regimens in adult group can if - 16
sentences: ##l 2005 ; 75 : 406. tan kr et al : neural basis for addictive properties of benzodiazepines. nature 2010 ; 463 : 769. c a s e s t u d y a n s w e r the patient was diagnosed with pathologic gambling sec - ondary to the dopamine agonist prescription. compulsive behavior including gambling, binge eating, or hypersexu - ality is observed in about 15 % of patients who receive dopamine agonist treatment. the condition is not related to parkinson ’ s disease, as compulsive behaviors also occur in patients with restless legs syndrome who are treated with the same medication. the incidence with levodopa is lower, and compulsive behavior is sometimes preceded by dose escalation., α - blocking agents ( five drugs ). these dmards and biologics are discussed alphabetically, independent of origin. abatacept mechanism of action abatacept is a co - stimulation modulator biologic that inhibits the activation of t cells ( see also chapter 55 ). after a t cell has engaged an antigen - presenting cell ( apc ), a second signal is produced by cd28 on the t cell that interacts with cd80 or cd86 on the apc, leading to t - cell activation. abatacept ( which contains the endogenous ligand ctla - 4 ) binds to cd80 and 86, thereby inhibiting the binding to cd28 and preventing the activation of t cells. pharmacokinetics abatacept is given as three intravenous infusion “ induction ” doses ( day 0, week 2, and week 4 ), followed by monthly infusions. the dose is based on body weight ; patients weighing less than 60 kg receiving 500 mg, those 60 – 100 kg receiving 750 mg, and those more than 100 kg receiving 1000 mg. dosing regimens in any adult group can be increased if needed. the terminal serum half - life is 13 – 16 days. co, chapter 33 agents used in anemias ; hematopoietic growth factors 587 groups. in particular, the depletion of tetrahydrofolate prevents synthesis of adequate supplies of the deoxythymidylate ( dtmp ) and purines required for dna synthesis in rapidly dividing cells, as shown in figure 33 – 3, section 2. the accumulation of folate as n 5 - methyltetrahydrofolate and the associated depletion of tetra - hydrofolate cofactors in vitamin b 12 deficiency have been referred to as the “ methylfolate trap. ” this is the biochemical step whereby vitamin b 12 and folic acid metabolism are linked, and it explains why the megaloblastic anemia of vitamin b 12 deficiency can be partially corrected by ingestion of large amounts of folic acid. folic acid can be reduced to dihydrofolate by the enzyme dihydro - folate reductase ( figure 33 – 3, section 3 ) and thereby serve as a source of the tetrahydrofolate required for synthesis of the purines and dtmp required for dna synthesis. vitamin b 12 deficiency causes the accumulation of homo - cysteine due to reduced formation, source_sentence: in after a successful when, definition, no longer dependent. the level : understand the long term changes by of initial molecular cellular targets must be a com approaches animals and functional revealed target this the teg area vta a tiny structure tip brainstem, which amygdala, hippocampus, drugs of abuse christian retired and and parkinson ’ disease age at time, neurologist prescribed restore dopamine levels. symptoms start fluctuate and dopamine role later, he devel oped a interest gambling, buying lottery and visiting casino he
sentences: common in addicts after a successful withdrawal when, by definition, they are no longer dependent. addictive drugs increase the level of dopamine : reinforcement to understand the long - term changes induced by drugs of abuse, their initial molecular and cellular targets must be identified. a com - bination of approaches in animals and humans, including functional imaging, has revealed the mesolimbic dopamine system as the prime target of addictive drugs. this system originates in the ventral teg - mental area ( vta ), a tiny structure at the tip of the brainstem, which projects to the nucleus accumbens, the amygdala, the hippocampus, 32 drugs of abuse christian luscher, md a retired accountant developed a tremor and slowing of movements and was diagnosed with parkinson ’ s disease at age 67. at that time, his neurologist prescribed levodopa to restore dopamine levels. two years later, motor symptoms start to fluctuate and the dopamine receptor agonist ropini - role is added to his treatment. ∗ a few months later, he devel - oped a strong interest in gambling, first buying lottery tickets and then visiting a casino almost every day. he concealed his gambling activity until, bleeding in over - the - counter use is low but still double that of over - the - counter ibuprofen ( perhaps due to a dose effect ). rare cases of allergic pneumonitis, leukocy - toclastic vasculitis, and pseudoporphyria as well as the common nsaid - associated adverse effects have been noted. oxaprozin oxaprozin is another propionic acid derivative nsaid. as noted in table 36 – 1, its major difference from the other members of this subgroup is a very long half - life ( 50 – 60 hours ), although oxapro - zin does not undergo enterohepatic circulation. it is mildly urico - suric, making it potentially more useful in gout than some other nsaids. otherwise, the drug has the same benefits and risks that are associated with other nsaids. piroxicam piroxicam, an oxicam ( figure 36 – 1 ), is a nonselective cox inhib - itor that at high concentrations also inhibits polymorphonuclear leukocyte migration, decreases oxygen radical production, and inhibits lymphocyte function. its long half - life, 4 ). recombinant human g - csf ( rhug - csf ; filgrastim ) is produced in a bacterial expression system. it is a nonglycosylated peptide of 175 amino acids, with a molecular weight of 18 kda. recombinant human gm - csf ( rhugm - csf ; sargramostim ) is produced in a yeast expression system. it is a partially glycosylated peptide of 127 amino acids, with three molecular species with molecular weights of 15, 500 ; 15, 800 ; and 19, 500. these preparations have serum half - lives of 2 – 7 hours after intravenous or subcutaneous administration. pegfilgrastim, a covalent conjugation product of filgrastim and a form of polyethylene glycol, has a much longer serum half - life than recombinant g - csf, and it can be injected once per myelo - suppressive chemotherapy cycle instead of daily for several days. lenograstim, used widely in europe, is a glycosylated form of recombinant g - csf. pharmacodynamics the myeloid growth, source_sentence: chapter drugs of 571 genetic by comparing relatively modest for very high of the relative liability of a drug – its heritability, that basis of common all is being genomic indicates that only perhaps even allele in combination phenotype. involved remains elusive. some substance - have identified ( dehydrogenase ), future will also focus on the mechanisms all drugs of abuse some not for substances without reward such the and the dissocia anesthetics ( drugs, primarily
sentences: chapter 33 agents used in anemias ; hematopoietic growth factors 589 catalyzed by the enzyme dihydrofolate reductase ( “ folate reductase ” ), to give dihydrofolic acid ( figure 33 – 3, section 3 ). tetrahydrofolate is subsequently transformed to folate cofactors possessing one - car - bon units attached to the 5 - nitrogen, to the 10 - nitrogen, or to both positions ( figure 33 – 3 ). folate cofactors are interconvertible by various enzymatic reactions and serve the important biochemical function of donating one - carbon units at various levels of oxida - tion. in most of these, tetrahydrofolate is regenerated and becomes available for reutilization. pharmacokinetics the average american diet contains 500 – 700 mcg of folates daily, 50 – 200 mcg of which is usually absorbed, depending on metabolic requirements. pregnant women may absorb as much as 300 – 400 mcg of folic acid daily. various forms of folic acid are present in a wide variety of plant and animal tissues ; the richest sources are yeast, liver, kidney, and green vegetables, 602 section vi drugs used to treat diseases of the blood, inflammation, & gout amputation or organ failure. venous clots tend to be more fibrin - rich, contain large numbers of trapped red blood cells, and are recognized pathologically as red thrombi. venous thrombi can cause severe swelling and pain of the affected extremity, but the most feared consequence is pulmonary embolism. this occurs when part or all of the clot breaks off from its location in the deep venous system and travels as an embolus through the right side of the heart and into the pulmonary arterial circulation. sudden occlusion of a large pulmonary artery can cause acute right heart failure and sudden death. in addition lung ischemia or infarction will occur distal to the occluded pulmonary arterial segment. such emboli usually arise from the deep venous system of the proximal lower extremities or pelvis. although all thrombi are mixed, the platelet nidus dominates the arterial thrombus and the fibrin tail dominates the venous thrombus. blood coagulation cascade blood coagulates due to the transformation of soluble fibrinogen into insoluble fi, chapter 32 drugs of abuse 571 of environmental and genetic factors. heritability of addiction, as determined by comparing monozygotic with dizygotic twins, is relatively modest for cannabinoids but very high for cocaine. it is of interest that the relative risk for addiction ( addiction liability ) of a drug ( table 32 – 1 ) correlates with its heritability, suggesting that the neurobiologic basis of addiction common to all drugs is what is being inherited. further genomic analysis indicates that only a few alleles ( or perhaps even a single recessive allele ) need to function in combination to produce the phenotype. however, identification of the genes involved remains elusive. although some substance - specific candidate genes have been identified ( eg, alcohol dehydrogenase ), future research will also focus on genes implicated in the neurobiologic mechanisms common to all addictive drugs. nonaddictive drugs of abuse some drugs of abuse do not lead to addiction. this is the case for substances that alter perception without causing sensations of reward and euphoria, such as the hallucinogens and the dissocia - tive anesthetics ( table 32 – 1 ). unlike addictive drugs, which primarily
pipeline_tag: sentence-similarity
library_name: sentence-transformers
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Created: 2025-05-28 13:25:39