Model: potsu-potsu/medembed-small-biomedical-matryoshka-v2
Author: potsu-potsu
Pipeline: sentence-similarity
Library: sentence-transformers
Tags: sentence-transformers, safetensors, bert, sentence-similarity, feature-extraction, generated_from_trainer, dataset_size:4012, loss:MatryoshkaLoss, loss:MultipleNegativesRankingLoss, en, arxiv:1908.10084, arxiv:2205.13147, arxiv:1705.00652, license:apache-2.0, model-index, text-embeddings-inference, endpoints_compatible, region:us
Card metadata: language: en
license: apache-2.0
tags: sentence-transformers, sentence-similarity, feature-extraction, generated_from_trainer, dataset_size:4012, loss:MatryoshkaLoss, loss:MultipleNegativesRankingLoss
widget: source_sentence: Do cephalopods use RNA editing less frequently than other species?
sentences: Extensive messenger RNA editing generates transcript and protein diversity in genes involved in neural excitability, as previously described, as well as in genes participating in a broad range of other cellular functions. , GV1001 is a 16-amino-acid vaccine peptide derived from the human telomerase reverse transcriptase sequence. It has been developed as a vaccine against various cancers., Using acetyl-specific K516 antibodies, we show that acetylation of endogenous S6K1 at this site is potently induced upon growth factor stimulation. We propose that K516 acetylation may serve to modulate important kinase-independent functions of S6K1 in response to growth factor signalling. Following mitogen stimulation, S6Ks interact with the p300 and p300/CBP-associated factor (PCAF) acetyltransferases. S6Ks can be acetylated by p300 and PCAF in vitro and S6K acetylation is detected in cells expressing p300, source_sentence: Can pets affect infant microbiomed?
sentences: Yes, exposure to household furry pets influences the gut microbiota of infants., Thiazovivin is a selective small molecule that directly targets Rho-associated kinase (ROCK) and increases expression of pluripotency factors.,  Here, we present evidence that the calcium/calmodulin-dependent protein kinase IV (CaMK4) is increased and required during Th17 cell differentiation. Inhibition of CaMK4 reduced Il17 transcription through decreased activation of the cAMP response element modulator a (CREM-a) and reduced activation of the AKT/mTOR pathway, which is known to enhance Th17 differentiation. CAMK4 knockdown and kinase-dead mutant inhibited crocin-mediated HO-1 expression, Nrf2 activation, and phosphorylation of Akt, indicating that HO-1 expression is mediated by CAMK4 and that Akt is a downstream mediator of CAMK4 in crocin signaling, source_sentence: In what proportion of children with heart failure has Enalapril been shown to be safe and effective?
sentences: 5-HT2A (5-hydroxytryptamine type 2a) receptor can be evaluated with the [18F]altanserin., In children with heart failure evidence of the effect of enalapril is empirical. Enalapril was clinically safe and effective in 50% to 80% of for children with cardiac failure secondary to congenital heart malformations before and after cardiac surgery,  impaired ventricular function , valvar regurgitation,  congestive cardiomyopathy,  , arterial hypertension, life-threatening arrhythmias coexisting with circulatory insufficiency.   
ACE inhibitors have shown a transient beneficial effect on heart failure due to anticancer drugs and possibly a beneficial effect in muscular dystrophy-associated cardiomyopathy, which deserves further studies., necroptosis
apoptosis  
pro-survival/inflammation NF-κB activation, source_sentence: How are SAHFS created?
sentences: In particular, up to 17% of neutrophil nuclei of healthy women exhibit a drumstick-shaped appendage that contains the inactive X chromosome., miR-1, miR-133, miR-208a, miR-206, miR-494, miR-146a, miR-222, miR-21, miR-221, miR-20a, miR-133a, miR-133b, miR-23, miR-107 and miR-181 are involved in exercise adaptation, Cellular senescence-associated heterochromatic foci (SAHFS) are a novel type of chromatin condensation involving alterations of linker histone H1 and linker DNA-binding proteins. SAHFS can be formed by a variety of cell types, but their mechanism of action remains unclear., source_sentence: What are the effects of the deletion of all three Pcdh clusters (tricluster deletion) in mice?
sentences: Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly. The vertebrate clustered protocadherin (Pcdh) cell surface proteins are encoded by three closely linked gene clusters (Pcdhα, Pcdhβ, and Pcdhγ). Although deletion of individual Pcdh clusters had subtle phenotypic consequences, the loss of all three clusters (tricluster deletion) led to a severe axonal arborization defect and loss of self-avoidance., The myocyte enhancer factor-2 (MEF2) proteins are MADS-box transcription factors that are essential for differentiation of all muscle lineages but their mechanisms of action remain largely undefined. MEF2C expression initiates cardiomyogenesis, resulting in the up-regulation of Brachyury T, bone morphogenetic protein-4, Nkx2-5, GATA-4, cardiac alpha-actin, and myosin heavy chain expression. Inactivation of the MEF2C gene causes cardiac developmental arrest and severe downregulation of a number of cardiac markers including atrial natriuretic factor (ANF). BMP-2, a regulator of cardiac development during embryogenesis, was shown to increase PI 3-kinase activity in cardiac precursor cells, resulting in increased expression of sarcomeric myosin heavy chain (MHC) and MEF-2A. Furthermore, expression of MEF-2A increased MHC expression in a PI 3-kinase-dependent manner. Other studies showed that Gli2 and MEF2C proteins form a complex, capable of synergizing on cardiomyogenesis-related promoters. Dominant interference of calcineurin/mAKAP binding blunts the increase in MEF2 transcriptional activity seen during myoblast differentiation, as well as the expression of endogenous MEF2-target genes. These findings show that MEF-2 can direct early stages of cell differentiation into a cardiomyogenic pathway., Investigators proposed that there have been three extended periods in the evolution of gene regulatory elements. Early vertebrate evolution was characterized by regulatory gains near transcription factors and developmental genes, but this trend was replaced by innovations near extracellular signaling genes, and then innovations near posttranslational protein modifiers.
pipeline_tag: sentence-similarity
library_name: sentence-transformers
metrics: cosine_accuracy@10, cosine_accuracy@15, cosine_accuracy@20, cosine_accuracy@25, cosine_accuracy@30, cosine_precision@10, cosine_precision@15, cosine_precision@20, cosine_precision@25, cosine_precision@30, cosine_recall@10, cosine_recall@15, cosine_recall@20, cosine_recall@25, cosine_recall@30, cosine_ndcg@10, cosine_ndcg@20, cosine_ndcg@30, cosine_mrr@10, cosine_mrr@20, cosine_mrr@30, cosine_map@100
model-index: name: MedEmbed Biomedical MRL
results: task: type: information-retrieval
name: Information Retrieval
dataset: name: dim 384
type: dim_384
metrics: type: cosine_accuracy@10
value: 0.9165487977369166
name: Cosine Accuracy@10
verified: no, type: cosine_accuracy@15
value: 0.9264497878359265
name: Cosine Accuracy@15
verified: no, type: cosine_accuracy@20
value: 0.9335219236209336
name: Cosine Accuracy@20
verified: no, type: cosine_accuracy@25
value: 0.9377652050919377
name: Cosine Accuracy@25
verified: no, type: cosine_accuracy@30
value: 0.9405940594059405
name: Cosine Accuracy@30
verified: no, type: cosine_precision@10
value: 0.39080622347949084
name: Cosine Precision@10
verified: no, type: cosine_precision@15
value: 0.3223008015087223
name: Cosine Precision@15
verified: no, type: cosine_precision@20
value: 0.27128712871287125
name: Cosine Precision@20
verified: no, type: cosine_precision@25
value: 0.23383309759547385
name: Cosine Precision@25
verified: no, type: cosine_precision@30
value: 0.20495049504950497
name: Cosine Precision@30
verified: no, type: cosine_recall@10
value: 0.5941961725539775
name: Cosine Recall@10
verified: no, type: cosine_recall@15
value: 0.6588459266002943
name: Cosine Recall@15
verified: no, type: cosine_recall@20
value: 0.6987845481366459
name: Cosine Recall@20
verified: no, type: cosine_recall@25
value: 0.7271263980909579
name: Cosine Recall@25
verified: no, type: cosine_recall@30
value: 0.7470648467155192
name: Cosine Recall@30
verified: no, type: cosine_ndcg@10
value: 0.6798281187519497
name: Cosine Ndcg@10
verified: no, type: cosine_ndcg@20
value: 0.6888607498626206
name: Cosine Ndcg@20
verified: no, type: cosine_ndcg@30
value: 0.7001398203922595
name: Cosine Ndcg@30
verified: no, type: cosine_mrr@10
value: 0.7992041040838778
name: Cosine Mrr@10
verified: no, type: cosine_mrr@20
value: 0.8003780682112908
name: Cosine Mrr@20
verified: no, type: cosine_mrr@30
value: 0.8006679370996576
name: Cosine Mrr@30
verified: no, type: cosine_map@100
value: 0.6024888601083165
name: Cosine Map@100
verified: no, task: type: information-retrieval
name: Information Retrieval
dataset: name: dim 256
type: dim_256
metrics: type: cosine_accuracy@10
value: 0.9137199434229137
name: Cosine Accuracy@10
verified: no, type: cosine_accuracy@15
value: 0.9207920792079208
name: Cosine Accuracy@15
verified: no, type: cosine_accuracy@20
value: 0.9306930693069307
name: Cosine Accuracy@20
verified: no, type: cosine_accuracy@25
value: 0.9335219236209336
name: Cosine Accuracy@25
verified: no, type: cosine_accuracy@30
value: 0.942008486562942
name: Cosine Accuracy@30
verified: no, type: cosine_precision@10
value: 0.3857142857142857
name: Cosine Precision@10
verified: no, type: cosine_precision@15
value: 0.31730315888731736
name: Cosine Precision@15
verified: no, type: cosine_precision@20
value: 0.2668316831683168
name: Cosine Precision@20
verified: no, type: cosine_precision@25
value: 0.22975954738330975
name: Cosine Precision@25
verified: no, type: cosine_precision@30
value: 0.20146157472890147
name: Cosine Precision@30
verified: no, type: cosine_recall@10
value: 0.5815816835128447
name: Cosine Recall@10
verified: no, type: cosine_recall@15
value: 0.6466693808855584
name: Cosine Recall@15
verified: no, type: cosine_recall@20
value: 0.6870196160066245
name: Cosine Recall@20
verified: no, type: cosine_recall@25
value: 0.7141879792489384
name: Cosine Recall@25
verified: no, type: cosine_recall@30
value: 0.7385183365425335
name: Cosine Recall@30
verified: no, type: cosine_ndcg@10
value: 0.6685061016322212
name: Cosine Ndcg@10
verified: no, type: cosine_ndcg@20
value: 0.6771324435869726
name: Cosine Ndcg@20
verified: no, type: cosine_ndcg@30
value: 0.6890384560552142
name: Cosine Ndcg@30
verified: no, type: cosine_mrr@10
value: 0.7910211939561302
name: Cosine Mrr@10
verified: no, type: cosine_mrr@20
value: 0.7921511051985389
name: Cosine Mrr@20
verified: no, type: cosine_mrr@30
value: 0.792585727544801
name: Cosine Mrr@30
verified: no, type: cosine_map@100
value: 0.5894036821514587
name: Cosine Map@100
verified: no, task: type: information-retrieval
name: Information Retrieval
dataset: name: dim 128
type: dim_128
metrics: type: cosine_accuracy@10
value: 0.8925035360678925
name: Cosine Accuracy@10
verified: no, type: cosine_accuracy@15
value: 0.9108910891089109
name: Cosine Accuracy@15
verified: no, type: cosine_accuracy@20
value: 0.9137199434229137
name: Cosine Accuracy@20
verified: no, type: cosine_accuracy@25
value: 0.917963224893918
name: Cosine Accuracy@25
verified: no, type: cosine_accuracy@30
value: 0.9264497878359265
name: Cosine Accuracy@30
verified: no, type: cosine_precision@10
value: 0.3652050919377653
name: Cosine Precision@10
verified: no, type: cosine_precision@15
value: 0.30061291843470067
name: Cosine Precision@15
verified: no, type: cosine_precision@20
value: 0.25212164073550214
name: Cosine Precision@20
verified: no, type: cosine_precision@25
value: 0.21652050919377655
name: Cosine Precision@25
verified: no, type: cosine_precision@30
value: 0.1898161244695898
name: Cosine Precision@30
verified: no, type: cosine_recall@10
value: 0.5512769672278892
name: Cosine Recall@10
verified: no, type: cosine_recall@15
value: 0.6154662290501166
name: Cosine Recall@15
verified: no, type: cosine_recall@20
value: 0.6485567681988598
name: Cosine Recall@20
verified: no, type: cosine_recall@25
value: 0.6719245680679413
name: Cosine Recall@25
verified: no, type: cosine_recall@30
value: 0.6908677707954165
name: Cosine Recall@30
verified: no, type: cosine_ndcg@10
value: 0.6398051423289486
name: Cosine Ndcg@10
verified: no, type: cosine_ndcg@20
value: 0.6456353921240615
name: Cosine Ndcg@20
verified: no, type: cosine_ndcg@30
value: 0.6547564254914449
name: Cosine Ndcg@30
verified: no, type: cosine_mrr@10
value: 0.7783401809568713
name: Cosine Mrr@10
verified: no, type: cosine_mrr@20
value: 0.779954730744106
name: Cosine Mrr@20
verified: no, type: cosine_mrr@30
value: 0.7804545296760538
name: Cosine Mrr@30
verified: no, type: cosine_map@100
value: 0.5533539437575846
name: Cosine Map@100
verified: no, task: type: information-retrieval
name: Information Retrieval
dataset: name: dim 64
type: dim_64
metrics: type: cosine_accuracy@10
value: 0.8458274398868458
name: Cosine Accuracy@10
verified: no, type: cosine_accuracy@15
value: 0.8642149929278642
name: Cosine Accuracy@15
verified: no, type: cosine_accuracy@20
value: 0.8755304101838756
name: Cosine Accuracy@20
verified: no, type: cosine_accuracy@25
value: 0.8769448373408769
name: Cosine Accuracy@25
verified: no, type: cosine_accuracy@30
value: 0.8854314002828855
name: Cosine Accuracy@30
verified: no, type: cosine_precision@10
value: 0.32673267326732675
name: Cosine Precision@10
verified: no, type: cosine_precision@15
value: 0.2663837812352664
name: Cosine Precision@15
verified: no, type: cosine_precision@20
value: 0.22446958981612444
name: Cosine Precision@20
verified: no, type: cosine_precision@25
value: 0.19224893917963226
name: Cosine Precision@25
verified: no, type: cosine_precision@30
value: 0.16864686468646864
name: Cosine Precision@30
verified: no, type: cosine_recall@10
value: 0.4845924963940586
name: Cosine Recall@10
verified: no, type: cosine_recall@15
value: 0.5380506278500925
name: Cosine Recall@15
verified: no, type: cosine_recall@20
value: 0.5767274907725523
name: Cosine Recall@20
verified: no, type: cosine_recall@25
value: 0.597395783619348
name: Cosine Recall@25
verified: no, type: cosine_recall@30
value: 0.6174419090464666
name: Cosine Recall@30
verified: no, type: cosine_ndcg@10
value: 0.5695803205424111
name: Cosine Ndcg@10
verified: no, type: cosine_ndcg@20
value: 0.572179718408508
name: Cosine Ndcg@20
verified: no, type: cosine_ndcg@30
value: 0.5801741667185395
name: Cosine Ndcg@30
verified: no, type: cosine_mrr@10
value: 0.7235900630879412
name: Cosine Mrr@10
verified: no, type: cosine_mrr@20
value: 0.7256569302708415
name: Cosine Mrr@20
verified: no, type: cosine_mrr@30
value: 0.726015777068746
name: Cosine Mrr@30
verified: no, type: cosine_map@100
value: 0.4741746465087054
name: Cosine Map@100
verified: no
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Created: 2025-06-10 10:35:35