Model: potsu-potsu/medembed-small-biomedical-matryoshka-bt384
Author: potsu-potsu
Pipeline: sentence-similarity
Library: sentence-transformers
Tags: sentence-transformers, safetensors, bert, sentence-similarity, feature-extraction, generated_from_trainer, dataset_size:4012, loss:MatryoshkaLoss, loss:MultipleNegativesRankingLoss, en, arxiv:1908.10084, arxiv:2205.13147, arxiv:1705.00652, license:apache-2.0, model-index, text-embeddings-inference, endpoints_compatible, region:us
Card metadata: language: en
license: apache-2.0
tags: sentence-transformers, sentence-similarity, feature-extraction, generated_from_trainer, dataset_size:4012, loss:MatryoshkaLoss, loss:MultipleNegativesRankingLoss
widget: source_sentence: Do cephalopods use RNA editing less frequently than other species?
sentences: Extensive messenger RNA editing generates transcript and protein diversity in genes involved in neural excitability, as previously described, as well as in genes participating in a broad range of other cellular functions. , GV1001 is a 16-amino-acid vaccine peptide derived from the human telomerase reverse transcriptase sequence. It has been developed as a vaccine against various cancers., Using acetyl-specific K516 antibodies, we show that acetylation of endogenous S6K1 at this site is potently induced upon growth factor stimulation. We propose that K516 acetylation may serve to modulate important kinase-independent functions of S6K1 in response to growth factor signalling. Following mitogen stimulation, S6Ks interact with the p300 and p300/CBP-associated factor (PCAF) acetyltransferases. S6Ks can be acetylated by p300 and PCAF in vitro and S6K acetylation is detected in cells expressing p300, source_sentence: Can pets affect infant microbiomed?
sentences: Yes, exposure to household furry pets influences the gut microbiota of infants., Thiazovivin is a selective small molecule that directly targets Rho-associated kinase (ROCK) and increases expression of pluripotency factors.,  Here, we present evidence that the calcium/calmodulin-dependent protein kinase IV (CaMK4) is increased and required during Th17 cell differentiation. Inhibition of CaMK4 reduced Il17 transcription through decreased activation of the cAMP response element modulator a (CREM-a) and reduced activation of the AKT/mTOR pathway, which is known to enhance Th17 differentiation. CAMK4 knockdown and kinase-dead mutant inhibited crocin-mediated HO-1 expression, Nrf2 activation, and phosphorylation of Akt, indicating that HO-1 expression is mediated by CAMK4 and that Akt is a downstream mediator of CAMK4 in crocin signaling, source_sentence: In what proportion of children with heart failure has Enalapril been shown to be safe and effective?
sentences: 5-HT2A (5-hydroxytryptamine type 2a) receptor can be evaluated with the [18F]altanserin., In children with heart failure evidence of the effect of enalapril is empirical. Enalapril was clinically safe and effective in 50% to 80% of for children with cardiac failure secondary to congenital heart malformations before and after cardiac surgery,  impaired ventricular function , valvar regurgitation,  congestive cardiomyopathy,  , arterial hypertension, life-threatening arrhythmias coexisting with circulatory insufficiency.   
ACE inhibitors have shown a transient beneficial effect on heart failure due to anticancer drugs and possibly a beneficial effect in muscular dystrophy-associated cardiomyopathy, which deserves further studies., necroptosis
apoptosis  
pro-survival/inflammation NF-κB activation, source_sentence: How are SAHFS created?
sentences: In particular, up to 17% of neutrophil nuclei of healthy women exhibit a drumstick-shaped appendage that contains the inactive X chromosome., miR-1, miR-133, miR-208a, miR-206, miR-494, miR-146a, miR-222, miR-21, miR-221, miR-20a, miR-133a, miR-133b, miR-23, miR-107 and miR-181 are involved in exercise adaptation, Cellular senescence-associated heterochromatic foci (SAHFS) are a novel type of chromatin condensation involving alterations of linker histone H1 and linker DNA-binding proteins. SAHFS can be formed by a variety of cell types, but their mechanism of action remains unclear., source_sentence: What are the effects of the deletion of all three Pcdh clusters (tricluster deletion) in mice?
sentences: Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly. The vertebrate clustered protocadherin (Pcdh) cell surface proteins are encoded by three closely linked gene clusters (Pcdhα, Pcdhβ, and Pcdhγ). Although deletion of individual Pcdh clusters had subtle phenotypic consequences, the loss of all three clusters (tricluster deletion) led to a severe axonal arborization defect and loss of self-avoidance., The myocyte enhancer factor-2 (MEF2) proteins are MADS-box transcription factors that are essential for differentiation of all muscle lineages but their mechanisms of action remain largely undefined. MEF2C expression initiates cardiomyogenesis, resulting in the up-regulation of Brachyury T, bone morphogenetic protein-4, Nkx2-5, GATA-4, cardiac alpha-actin, and myosin heavy chain expression. Inactivation of the MEF2C gene causes cardiac developmental arrest and severe downregulation of a number of cardiac markers including atrial natriuretic factor (ANF). BMP-2, a regulator of cardiac development during embryogenesis, was shown to increase PI 3-kinase activity in cardiac precursor cells, resulting in increased expression of sarcomeric myosin heavy chain (MHC) and MEF-2A. Furthermore, expression of MEF-2A increased MHC expression in a PI 3-kinase-dependent manner. Other studies showed that Gli2 and MEF2C proteins form a complex, capable of synergizing on cardiomyogenesis-related promoters. Dominant interference of calcineurin/mAKAP binding blunts the increase in MEF2 transcriptional activity seen during myoblast differentiation, as well as the expression of endogenous MEF2-target genes. These findings show that MEF-2 can direct early stages of cell differentiation into a cardiomyogenic pathway., Investigators proposed that there have been three extended periods in the evolution of gene regulatory elements. Early vertebrate evolution was characterized by regulatory gains near transcription factors and developmental genes, but this trend was replaced by innovations near extracellular signaling genes, and then innovations near posttranslational protein modifiers.
pipeline_tag: sentence-similarity
library_name: sentence-transformers
metrics: cosine_accuracy@10, cosine_accuracy@15, cosine_accuracy@20, cosine_accuracy@25, cosine_accuracy@30, cosine_precision@10, cosine_precision@15, cosine_precision@20, cosine_precision@25, cosine_precision@30, cosine_recall@10, cosine_recall@15, cosine_recall@20, cosine_recall@25, cosine_recall@30, cosine_ndcg@10, cosine_ndcg@20, cosine_ndcg@30, cosine_mrr@10, cosine_mrr@20, cosine_mrr@30, cosine_map@100
model-index: name: MedEmbed Biomedical MRL
results: task: type: information-retrieval
name: Information Retrieval
dataset: name: dim 384
type: dim_384
metrics: type: cosine_accuracy@10
value: 0.9165487977369166
name: Cosine Accuracy@10
verified: no, type: cosine_accuracy@15
value: 0.9264497878359265
name: Cosine Accuracy@15
verified: no, type: cosine_accuracy@20
value: 0.9292786421499293
name: Cosine Accuracy@20
verified: no, type: cosine_accuracy@25
value: 0.9377652050919377
name: Cosine Accuracy@25
verified: no, type: cosine_accuracy@30
value: 0.942008486562942
name: Cosine Accuracy@30
verified: no, type: cosine_precision@10
value: 0.3916548797736916
name: Cosine Precision@10
verified: no, type: cosine_precision@15
value: 0.32333804809052336
name: Cosine Precision@15
verified: no, type: cosine_precision@20
value: 0.27065063649222065
name: Cosine Precision@20
verified: no, type: cosine_precision@25
value: 0.23428571428571432
name: Cosine Precision@25
verified: no, type: cosine_precision@30
value: 0.20523338048090525
name: Cosine Precision@30
verified: no, type: cosine_recall@10
value: 0.5943841592438113
name: Cosine Recall@10
verified: no, type: cosine_recall@15
value: 0.6621379203665827
name: Cosine Recall@15
verified: no, type: cosine_recall@20
value: 0.6999711186495905
name: Cosine Recall@20
verified: no, type: cosine_recall@25
value: 0.7301435226683588
name: Cosine Recall@25
verified: no, type: cosine_recall@30
value: 0.7514129297371369
name: Cosine Recall@30
verified: no, type: cosine_ndcg@10
value: 0.6811098268060495
name: Cosine Ndcg@10
verified: no, type: cosine_ndcg@20
value: 0.6896928658980618
name: Cosine Ndcg@20
verified: no, type: cosine_ndcg@30
value: 0.7020523895942326
name: Cosine Ndcg@30
verified: no, type: cosine_mrr@10
value: 0.8049291663860265
name: Cosine Mrr@10
verified: no, type: cosine_mrr@20
value: 0.8058376094558389
name: Cosine Mrr@20
verified: no, type: cosine_mrr@30
value: 0.8063761125175677
name: Cosine Mrr@30
verified: no, type: cosine_map@100
value: 0.6033960222049608
name: Cosine Map@100
verified: no, task: type: information-retrieval
name: Information Retrieval
dataset: name: dim 256
type: dim_256
metrics: type: cosine_accuracy@10
value: 0.9080622347949081
name: Cosine Accuracy@10
verified: no, type: cosine_accuracy@15
value: 0.925035360678925
name: Cosine Accuracy@15
verified: no, type: cosine_accuracy@20
value: 0.9306930693069307
name: Cosine Accuracy@20
verified: no, type: cosine_accuracy@25
value: 0.9363507779349364
name: Cosine Accuracy@25
verified: no, type: cosine_accuracy@30
value: 0.9391796322489392
name: Cosine Accuracy@30
verified: no, type: cosine_precision@10
value: 0.3854314002828854
name: Cosine Precision@10
verified: no, type: cosine_precision@15
value: 0.3187175860443187
name: Cosine Precision@15
verified: no, type: cosine_precision@20
value: 0.26739745403111737
name: Cosine Precision@20
verified: no, type: cosine_precision@25
value: 0.23072135785007072
name: Cosine Precision@25
verified: no, type: cosine_precision@30
value: 0.20141442715700142
name: Cosine Precision@30
verified: no, type: cosine_recall@10
value: 0.5817702555910013
name: Cosine Recall@10
verified: no, type: cosine_recall@15
value: 0.6538450776429151
name: Cosine Recall@15
verified: no, type: cosine_recall@20
value: 0.6925041876736199
name: Cosine Recall@20
verified: no, type: cosine_recall@25
value: 0.720457864974858
name: Cosine Recall@25
verified: no, type: cosine_recall@30
value: 0.7370075029853262
name: Cosine Recall@30
verified: no, type: cosine_ndcg@10
value: 0.6709067417297389
name: Cosine Ndcg@10
verified: no, type: cosine_ndcg@20
value: 0.6814078028973749
name: Cosine Ndcg@20
verified: no, type: cosine_ndcg@30
value: 0.6916093843149187
name: Cosine Ndcg@30
verified: no, type: cosine_mrr@10
value: 0.7983829505399519
name: Cosine Mrr@10
verified: no, type: cosine_mrr@20
value: 0.8000527348653235
name: Cosine Mrr@20
verified: no, type: cosine_mrr@30
value: 0.8003931312237997
name: Cosine Mrr@30
verified: no, type: cosine_map@100
value: 0.5931838235595164
name: Cosine Map@100
verified: no, task: type: information-retrieval
name: Information Retrieval
dataset: name: dim 128
type: dim_128
metrics: type: cosine_accuracy@10
value: 0.8953323903818954
name: Cosine Accuracy@10
verified: no, type: cosine_accuracy@15
value: 0.9094766619519095
name: Cosine Accuracy@15
verified: no, type: cosine_accuracy@20
value: 0.9165487977369166
name: Cosine Accuracy@20
verified: no, type: cosine_accuracy@25
value: 0.9207920792079208
name: Cosine Accuracy@25
verified: no, type: cosine_accuracy@30
value: 0.9236209335219236
name: Cosine Accuracy@30
verified: no, type: cosine_precision@10
value: 0.36534653465346534
name: Cosine Precision@10
verified: no, type: cosine_precision@15
value: 0.3011786892975012
name: Cosine Precision@15
verified: no, type: cosine_precision@20
value: 0.25268741159830266
name: Cosine Precision@20
verified: no, type: cosine_precision@25
value: 0.21646393210749648
name: Cosine Precision@25
verified: no, type: cosine_precision@30
value: 0.1897218293257897
name: Cosine Precision@30
verified: no, type: cosine_recall@10
value: 0.5519363426569764
name: Cosine Recall@10
verified: no, type: cosine_recall@15
value: 0.6176251635703729
name: Cosine Recall@15
verified: no, type: cosine_recall@20
value: 0.6548648102726041
name: Cosine Recall@20
verified: no, type: cosine_recall@25
value: 0.6746515664376324
name: Cosine Recall@25
verified: no, type: cosine_recall@30
value: 0.6924453170636061
name: Cosine Recall@30
verified: no, type: cosine_ndcg@10
value: 0.6398016296961992
name: Cosine Ndcg@10
verified: no, type: cosine_ndcg@20
value: 0.6474298612392543
name: Cosine Ndcg@20
verified: no, type: cosine_ndcg@30
value: 0.6550217405015739
name: Cosine Ndcg@30
verified: no, type: cosine_mrr@10
value: 0.7771788913585234
name: Cosine Mrr@10
verified: no, type: cosine_mrr@20
value: 0.778695790755643
name: Cosine Mrr@20
verified: no, type: cosine_mrr@30
value: 0.7789831094904741
name: Cosine Mrr@30
verified: no, type: cosine_map@100
value: 0.5546470716729804
name: Cosine Map@100
verified: no, task: type: information-retrieval
name: Information Retrieval
dataset: name: dim 64
type: dim_64
metrics: type: cosine_accuracy@10
value: 0.842998585572843
name: Cosine Accuracy@10
verified: no, type: cosine_accuracy@15
value: 0.8613861386138614
name: Cosine Accuracy@15
verified: no, type: cosine_accuracy@20
value: 0.8712871287128713
name: Cosine Accuracy@20
verified: no, type: cosine_accuracy@25
value: 0.8769448373408769
name: Cosine Accuracy@25
verified: no, type: cosine_accuracy@30
value: 0.8854314002828855
name: Cosine Accuracy@30
verified: no, type: cosine_precision@10
value: 0.3263083451202263
name: Cosine Precision@10
verified: no, type: cosine_precision@15
value: 0.2661008958038661
name: Cosine Precision@15
verified: no, type: cosine_precision@20
value: 0.22461103253182463
name: Cosine Precision@20
verified: no, type: cosine_precision@25
value: 0.19185289957567184
name: Cosine Precision@25
verified: no, type: cosine_precision@30
value: 0.167986798679868
name: Cosine Precision@30
verified: no, type: cosine_recall@10
value: 0.48052822307946375
name: Cosine Recall@10
verified: no, type: cosine_recall@15
value: 0.5398264569305472
name: Cosine Recall@15
verified: no, type: cosine_recall@20
value: 0.5760562145043948
name: Cosine Recall@20
verified: no, type: cosine_recall@25
value: 0.5974817039044938
name: Cosine Recall@25
verified: no, type: cosine_recall@30
value: 0.6172512046837344
name: Cosine Recall@30
verified: no, type: cosine_ndcg@10
value: 0.570594875254224
name: Cosine Ndcg@10
verified: no, type: cosine_ndcg@20
value: 0.5741514079450971
name: Cosine Ndcg@20
verified: no, type: cosine_ndcg@30
value: 0.5816429079968766
name: Cosine Ndcg@30
verified: no, type: cosine_mrr@10
value: 0.7213539211063957
name: Cosine Mrr@10
verified: no, type: cosine_mrr@20
value: 0.7233478459971812
name: Cosine Mrr@20
verified: no, type: cosine_mrr@30
value: 0.7238905083675293
name: Cosine Mrr@30
verified: no, type: cosine_map@100
value: 0.47812407622249736
name: Cosine Map@100
verified: no
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Created: 2025-06-10 09:21:40