Model: csong97/setfit-jnj-relevancy
Author: csong97
Pipeline: text-classification
Library: setfit
Tags: setfit, safetensors, mpnet, sentence-transformers, text-classification, generated_from_setfit_trainer, arxiv:2209.11055, base_model:sentence-transformers/paraphrase-mpnet-base-v2, base_model:finetune:sentence-transformers/paraphrase-mpnet-base-v2, model-index, region:us
Base models (finetune): id: sentence-transformers/paraphrase-mpnet-base-v2
Card metadata: library_name: setfit
tags: setfit, sentence-transformers, text-classification, generated_from_setfit_trainer
metrics: accuracy
widget: johnson  johnsons cell therapy carvykti shows better survival rate in pretreated blood cancer patients    finanzenat

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expanding roles new approaches for pharmacists in managing graftvshost disease


june  

by gillian mcgovern assistant editor

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pharmacy practice in focus oncologyjune 

volume 

issue 



when treating patients with graftvshost disease pharmacists are often responsible for selecting treatment regimens while navigating other spheres of care

 blob  medical panelists   credit africa studio  stockadobecom

 credit africa studio  stockadobecom

 

there is no consensus when treating patients with graftvshost disease gvhd because of the varying disease states and different interpretations among providers explained amir ali pharmd bcop during a pharmacy times clinical forum discussion ali is a clinical pharmacist specialist in hematologyoncology and bone marrow transplant bmt at the university of southern california norris comprehensive cancer center in los angeles as the treatment landscape for gvhd continues to develop and new data emerge pharmacists can develop more individualized regimens for patients while finding their roles in treatment management are expanding

although steroids are typically the universal option for frontline treatment ali emphasized that longterm steroid use isn’t ideal due to adverse events aes—such as fibrosis which can be irreversible in patients with chronic gvhd cgvhd—and the possibility of disease becoming refractory according to ali there are only  fdaapproved agents for the treatment of patients with gvhd ibrutinib imbruvica janssen biotech inc pharmacyclics llc which was approved in  belumosudil rezurock kadmon pharmaceuticals llc which was approved in july  and ruxolitinib jakafi incyte which was approved in september  and has indications for cgvhd

as an example ali highlighted a patient who had cgvhd in the skin and joints further he decided not to treat the patient with ibrutinib due to the lack of efficacy shown in data from clinical trials using other data he chose to treat the patient with belumosudil because it demonstrated response rates in approximately  of patients who received the treatment realworld data ali said can be important for health care providers when determining individualized treatment plans for patients

because steroids aren’t ideal in the long term there are different practices in place to remove patients from this highdose treatment as soon as possible whether it’s adhering to a particular timeline or tapering according to tina gu pharmd bcop clinical pharmacist in pediatric hematologyoncology and bmt at the university of california san francisco ucsf benioff children’s hospital her practice tends to taper patients off steroids before they develop refractory disease or experience aes

“our standard is to try to start tapering after  weeks of highdose steroids but what we’re seeing more at our hospital is adding a second agent earlier on so we’re not even waiting for patients with gvhd to develop steroidrefractory disease and we’re adding a second oral agent earlier because our providers are anticipating that it’s already going to be hard to taper patients off their steroids so by adding the steroidsparing agent providers may be more successful in getting them off these agents” gu said during the discussion

furthermore during the tapering of steroids patients may experience cgvhdrelated exacerbation or recurrence pharmacists may want to increase the dose or begin switching the patient to a new drug sandy on pharmd clinical pharmacist in hematology and bmt at stanford health care in california noted that although her institution wants patients off steroids as soon as possible she continues the use of steroids because she is already considering what additional treatment can be used currently and in secondline treatment additionally for patients who experience a partial response to steroids the next steps can be determined depending on which organ system is involved in the patient’s gvhd state

angela lee pharmd bcop clinical pharmacist in hematologyoncology bmt and cellular therapies at ucsf said that addon treatments can rely heavily on patient characteristics such as their response to steroids which organs are affected by their gvhd or the individual drug’s mechanism of action

“addon treatment also depends on the organ affected because there are some data that show belumosudil may be more effective in the lung setting for patients who present with lung disease up front that may be something that is considered along with their regimen” lee said during the discussion “for what ali was mentioning earlier it also depends on the mechanism of action such as ruxolitinib if providers want to target cgvhd earlier they might want to consider using that first”

pharmacists particularly bmt pharmacists have a significant role when caring for patients with gvhd according to the panelists pharmacists are typically the most constant health care professionals whom patients see when receiving treatment for their disease state especially in gvhd treatment pharmacists tend to know the data better than other health care professionals and help make recommendations and decisions for tapering medications or treatment selection according to the panelists

additionally pharmacists are also the ones who are planning treatment pathways around insurance issues lee explained that she and other pharmacists at her practice must often plan far in advance because certain insurance companies are not always specific in what they are able to cover or may not know which limited distribution specialty pharmacies carry certain medications such as ruxolitinib ali echoed this point by emphasizing his experiences when treating patients

“even coming up with treatments we do that all the time i have providers come up to me almost daily and share a case with me and say ‘this is the situation’ and every practice is different but that’s the direction we’re heading in” ali explained during the discussion “so having a pharmacist on the patient’s health care team to break everything down is extremely important”

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biopharma pharma

takeda commits m for chance to bring immunotherapy to alzheimer’s disease


takeda pharmaceutical has secured an option on an alzheimer’s disease immunotherapy from ac immune that is on track to report its first phase  data later this quarter exercising the option would make takeda responsible for phase  testing of the therapy putting ac immune in line for up to  billion in milestone payments

by frank vinluan on may  

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alzheimer’s disease can be treated with antibody drugs that reduce levels of amyloid beta protein in the brain clinicalstage biotech company ac immune is developing a novel therapy that sparks the immune system to clear away amyloid plaque and takeda pharmaceutical sees enough promise in this approach to commit  million for the opportunity to pick up this experimental therapy

the ac immune drug codenamed aci is currently being evaluated in the phase  portion of a phase b study under the deal terms announced monday takeda’s upfront payment gives it an exclusive option to license global rights to this immunotherapy

aci is an immunogenic peptide that is presented to the immune system’s b cells in a way that mimics the pathological form of amyloid beta this presentation is intended to spark activity from antibodies that bind to pathological forms of the protein in preclinical research lausanne switzerlandbased ac immune has reported that the drug led to higher blood levels of immunoglobulin g antibodies that were associated with reduction in amyloid plaque in tests in monkeys ac immune reported a favorable safety profile for the drug

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ac immune is responsible for completing the placebocontrolled phase b study which is evaluating for aci in patients with early alzheimer’s the study is also testing the immunotherapy as a treatment for patients with down syndrome under the takeda agreement the japanese pharmaceutical giant may exercise its option after it receives predefined clinical data on the first three alzheimer’s patient cohorts from the ongoing study ac immune said in a regulatory filing the first phase  data on amyloid plaque reduction after six months of treatment will be reported in the current quarter potentially paving the way for phase  testing ac immune said monday in its report of financial results for the first quarter of 

“we believe the maximum impact of aci can best be realized by partnering with takeda at this critical juncture in its development which will help us move rapidly into phase ” ac immune ceo andrea pfeifer said in a prepared statement “this agreement allows us to leverage the developmental expertise strategic vision and financial capacity of an accomplished organization that has demonstrated its ability to execute the type of comprehensive global program required for phase  trials in alzheimer’s disease while allowing us to focus on completing phase b development and accelerating our efforts to replicate this success with enhanced funding for our earlystage pipeline”

updated to add the following three paragraphs with analyst commentary an antiamyloid beta or “abeta” approach already has partial validation from the fda approval of the amyloid plaque antibody busting drug leqemb from eisai as well as donanemab an eli lilly drug still under regulatory review leerink partners analyst marc goodman wrote in a march research note but safety could be a key differentiator for an alzheimer’s immunotherapy antibody drugs developed for the disease introduce the risk of amyloidrelating imaging abnormalities aria brain bleeding and swelling that is a known adverse effect of this class of therapies an earlier formulation of ac immune’s therapy yielded mixed phase  data while the results showed favorable safety with no signs of aria the immune response was “suboptimal” goodman said

aci is a new formulation incorporating changes intended to boost the immune response goodman said translation of immune response to amyloid beta clearance andor clinical benefit remains a key question also active immunotherapy may take longer to show an effect compared with antibody drugs he added while those questions remain unanswered so far the takeda deal is positive news for ac immune goodman wrote in a monday research note

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“once again management has executed on a significant partnership with a big pharma company to develop an asset that has received minimal value in the stock confirming our longterm thesis that this management team can leverage its two proprietary drug discovery platforms and diversified pipeline to drive value” goodman said

the agreement makes ac immune eligible for up to  billion in milestone payments which includes an option exercise fee in the lowtomidhundred millions of dollars according to the regulatory filing  after exercising that option takeda will be responsible for clinical development of the alzheimer’s drug takeda will also handle regulatory submissions as well as commercialization if the drug is approved ac immune will receive royalties from takeda’s sales of the immunotherapy

aci would give takeda another opportunity to address alzheimer’s but with a drug candidate that has been derisked with clinical data the company previously partnered with denali therapeutics on the development of an antibody engineered to penetrate the brain to hit and activate a target called trem last august the two companies announced they would discontinue clinical development of this alzheimer’s drug after safety signals emerged in phase  testing takeda also has a research collaboration with cure network dolby acceleration partners focused on developing small molecules that target tau in alzheimer’s and other brain disorders

ac immune has other alliances in alzheimer’s its antitau immunotherapy aci is currently in midstage clinical development under a partnership with johnson  johnson subsidiary janssen pharmaceuticals a tau aggregation inhibitor is in preclinical development under a partnership with eli lilly two ac immune antibodies semorinemab and crenezumab were partnered with roche’s genentech division but after disappointing clinical trial results genentech terminated the alliance early this year returning to ac immune rights to both antibodies

public domain  by flickr user scitechtrend

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   perseus therapeutics announces development of tslp antibody for prevention of hair loss in cancer patients and treatment of inflammatory diseases with wellknown cro partner

perseus therapeutics announces development of tslp antibody for prevention of hair loss in cancer patients and treatment of inflammatory diseases with wellknown cro partner


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new york may   prnewswire  perseus therapeutics a pioneering biopharmaceutical company based in new york city is proud to announce the development of a novel thymic stromal lymphopoietin tslp antibody aimed at preventing hair loss in cancer patients and treating a range of inflammatory diseases including asthma

  pegasus horse next to the words perseus therapeutics inc

tslp antibodies have recently gained significant attention in the medical and pharmaceutical communities these antibodies have shown potential in addressing various inflammatory and allergic conditions driven by their promising efficacy data and the unmet medical needs they aim to fulfill

several companies and research groups are actively exploring tslp antibodies with notable developments including

   astrazeneca and amgen have developed tezepelumab the firstinclass antitslp monoclonal antibody approved for severe asthma treatment
   johnson  johnson acquired proteologix to access its bispecific antibody targeting tslp and il
   blackstone has launched uniquity to advance mercks phase  high potency tslp antibody
   innovent biologics is conducting a phase i study on ibi a dualfunction antibody targeting both ilrα and tslp
   sanofi and regeneron are developing sar a novel biologic targeting both tslp and il for asthma
   teva pharmaceuticals and biolojic design have entered into an exclusive license agreement to develop bispecific antibodies targeting tslp and il
   gsk recently acquired aiolos bio for  billion upfront to enhance its respiratory biologics portfolio with aio a phase  longacting antitslp monoclonal antibody

these strategic moves underscore the growing interest in tslp antibodies for treating a wide range of inflammatory and allergic conditions perseus therapeutics is poised to contribute to this dynamic field with its innovative approach to preventing hair loss in cancer patients a common and distressing side effect of cancer treatments and addressing other inflammatory diseases

perseus therapeutics is committed to advancing the science of tslp antibodies to meet critical unmet medical needs said joseph hernandez chairman and founder of perseus therapeutics our work aims not only to improve the quality of life for cancer patients by preventing hair loss but also to provide effective treatments for various inflammatory conditions

for more information about perseus therapeutics and its pipeline of innovative therapies please visit  or contact filecconvertwordtohtmlprimarycontentdownloadpath

about perseus therapeutics inc  
perseus therapeutics is a duke university spinout biopharmaceutical company dedicated to developing innovative therapies for cancer patients and those suffering from inflammatory diseases based in new york city perseus therapeutics is at the forefront of antibody research and development striving to bring new hope and improved outcomes to patients worldwide

  cision view original content to download multimedia

source perseus therapeutics inc

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johnson  johnson shares positive results for tar in highrisk bladder cancer


more than  cases of bladder cancer are diagnosed in the us every year

   pmlive

johnson  johnson jj has shared promising results for its investigational bladder cancer treatment approach tar at this year’s american urological association annual meeting

more than  people are diagnosed with bladder cancer in the us every year with nonmuscleinvasive bladder cancer nmibc accounting for up to  of all newly diagnosed cases

radical cystectomy the removal of the bladder and nearby structures and organs is currently recommended for nmibc patients who fail standardofcare bacillus calmetteguérin bcg immunotherapy however as nmibc usually affects older patients many may be unwilling or unfit to undergo this procedure

tar is an investigational targeted releasing system which enables the controlled release of the chemotherapy drug gemcitabine into the bladder this increases the amount of time the drug delivery system spends in the bladder and sustains local drug exposure according to jj

cohort two of the phase b sunrise trial has been evaluating tar as a monotherapy in patients with bcgunresponsive highrisk nmibc with carcinoma in situ who are ineligible for or decline radical cystectomy

results demonstrated a centrally confirmed complete response cr rate of  with  of crs achieved at the first disease assessment at week  and four of five patients who have completed two years of treatment remaining in cr

the estimated oneyear duration of response rate is  with median followup in responders of  weeks additionally  remained in cr at the data cutoff in january and none of the responders progressed to muscleinvasive bladder cancer or metastasis

“the high cr rate and durability of these responses observed in patients treated with tar underscores the potential of this treatment approach for patients with bcgunresponsive highrisk nmibc” said presenting author joseph jacob department of urology at upstate medical university

sunrise is also evaluating tar which has already been granted breakthrough therapy designation by the us food and drug administration in combination with the investigational antipd monoclonal antibody cetrelimab or cetrelimab alone in the same patient population

christopher cutie vice president disease area leader bladder cancer jj innovative medicine said “these results reinforce the potential of tar to transform the treatment landscape and our ongoing dedication to address unmet needs for patients facing this challenging disease”

article by emily kimber

th may 

from research

johnson  johnson  nonmuscleinvasive bladder cancer  oncology  sunrise  tar

 

 

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pipeline_tag: text-classification
inference: yes
base_model: sentence-transformers/paraphrase-mpnet-base-v2
model-index: name: SetFit with sentence-transformers/paraphrase-mpnet-base-v2
results: task: type: text-classification
name: Text Classification
dataset: name: Unknown
type: unknown
split: test
metrics: type: accuracy
value: 0.43103448275862066
name: Accuracy
verified: no
Likes: 0 | All-time downloads: 82
Created: 2024-07-31 21:17:56