Model: Timofey/PubMedBERT_Pathways_Context_Classifier
Author: Timofey
Pipeline: text-classification
Library: transformers
Tags: transformers, pytorch, bert, text-classification, ANDDigest, ANDSystem, arxiv:2007.15779, endpoints_compatible, region:us
Card metadata: tags: ANDDigest, ANDSystem
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widget: text: Deficient Mismatch Repair and Lymphocytic Response to Tumor as Prognostic Markers in Stage II Colon Cancer Patients. OBJECTIVE: To investigate the relationship between colon cancer subtypes defined by the status of tumor-infiltrating lymphocytes and mismatch repair (MMR) combination with clinicopathological features and survival. STUDY DESIGN: Observational study. PLACE AND DURATION OF STUDY: Department of Medical Oncology, HaydarpaAŸa Numune Research and Training Hospital, Istanbul, Turkey, from July 2010 to March 2020. METHODOLOGY: Eighty-three patients with operated stage II colon cancer were included in the study. Pathology, surgery and oncological treatment and follow-up information were obtained from patient files; And statistical analyses were performed on overall survival . Tumor-infiltrating lymphocytes and mismatch repair status was determined with the help of immunohistochemistry. RESULTS: TIL-high and deficient <andsystem-candidate> status were detected in 26 patients (31.3%) and 21 patients (25.3%), respectively. Tumors were divided into four subgroups according to tumor-infiltrating lymphocytes and MMR status. TIL-high/deficient mmr tumors had the most favourable prognosis, while TIL-low/proficient MMR tumors exhibited poor overall survival. CONCLUSION: The combination of tumor-infiltrating lymphocytes and MMR could enable us to differentiate patients' survival outcomes in more details. Therefore, considering that the tumor-infiltrating lymphocytes and MMR status, evaluated by IHC, may be a cost-effective and effective option for risk classification in patients with stage II colon cancer. Key Word: Lymphocytic response, Mismatch repair, Prognosis, Tumor-infiltrating lymphocytes, Stage II cancer, Colon cancer.
example_title: MMR, text: Rapid alkalinization factor peptide signaling controls the polytubey block in Arabidopsis. Fertilization of an egg by multiple sperm (polyspermy) leads to lethal genome imbalance and chromosome segregation defects. In Arabidopsis thaliana, the block to polyspermy is facilitated by a mechanism that prevents polytubey (the arrival of multiple pollen tubes to one ovule). We show here that FERONIA, ANJEA, and HERCULES RECEPTOR KINASE 1 receptor-like kinases located at the septum interact with pollen tube-specific RALF6, 7, 16, 36, and 37 peptide ligands to establish this polytubey block. The same combination of rapid alkalinization factor peptides and receptor complexes controls pollen tube reception and rupture inside the targeted ovule. Pollen tube rupture releases the polytubey block at the septum, which allows the emergence of secondary pollen tubes upon <andsystem-candidate> failure. Thus, orchestrated steps in the fertilization process in Arabidopsis are coordinated by the same signaling components to guarantee and optimize reproductive success.
example_title: fertilization
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Created: 2022-09-14 13:03:01