Model: sahithkumar7/final-mpnet-base-fullfinetuned-epoch5
Author: sahithkumar7
Pipeline: sentence-similarity
Library: sentence-transformers
Tags: sentence-transformers, safetensors, mpnet, sentence-similarity, feature-extraction, dense, generated_from_trainer, dataset_size:800, loss:MultipleNegativesRankingLoss, arxiv:1908.10084, arxiv:1705.00652, base_model:microsoft/mpnet-base, base_model:finetune:microsoft/mpnet-base, model-index, endpoints_compatible, region:us
Base models (finetune): id: microsoft/mpnet-base
Card metadata: tags: sentence-transformers, sentence-similarity, feature-extraction, dense, generated_from_trainer, dataset_size:800, loss:MultipleNegativesRankingLoss
base_model: microsoft/mpnet-base
widget: source_sentence: What is the department of medicine located at?
sentences: Publisher’s Note: MDPI stays neutral
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onon)

Copyright: © 2021 by the author.
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://
creativecommons.org/licenses/by/
4.0/).

Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medical College, 525 East 68th Street,
Room M-522, Box 130, New York, NY 10065, USA; str2020@med.cornell.edu or Stefan.Ryter@proterris.com, Results At the parameters used, the ultrasound did not directly affect bCSC proliferation, with no evident changes in
morphology. In contrast, the ultrasound protocol affected the migration and invasion ability of bCSCs, limiting their
capacity to advance while a major affection was detected on their angiogenic properties. LIPUS-treated bCSCs were
unable to transform into aggressive metastatic cancer cells, by decreasing their migration and invasion capacity as
well as vessel formation. Finally, RNA-seq analysis revealed major changes in gene expression, with 676 differentially, Tesfaye, M. & Savoldo, B. Adoptive cell therapy in
treating pediatric solid tumors. Curr. Oncol. Rep. 20,
73 (2018).

Marofi, F. et al. CAR T cells in solid tumors: challenges
and opportunities. Stem Cell Res. Ther. 12, 81 (2021).
Deng, Q. et al. Characteristics of anti-CD19 CAR T cell
infusion products associated with efficacy and toxicity

in patients with large B cell lymphomas. Nat. Med. 26,

1878-1887 (2020).
Boulch, M. A cross-talk between CAR T cell subsets
and the tumor microenvironment is essential for
sustained cytotoxic activity. Sci. Immunol. 6,
eabd4344 (2021)., source_sentence: What is the result of LIPUS treatment on the formation of new vessels and tubes?
sentences: apparatus), and mitochondrial damage, which then leads to eventual cell death [112,114].
Accordingly, alterations that affect the lysosomal-mitochondria relationship and their
metabolic equilibrium generate a defective metabolism, which contributes to disease pro-
gression [115]. Consequently, the identification of regulatory molecular links between these
two organelles will most probably cause the rise of novel targets for the treatment of NPC.
Therefore, we propose that members of the miRNA-17-92 cluster could be relevant actors, A tube formation assay was conducted on Matrigel to
study the impact of LIPUS stimulation on bCSCs’ angio-
genic activity (Fig. 5). After 2 h, both control and LIPUS-
stimulated cells exhibited signs of angiogenesis (Fig. 5A
and B). This observation was further confirmed by count-
ing the number of panel-like structures and vessels in
both conditions, which were slightly higher in control
cells (Fig. 5C). Statistical analysis using Student’s t-test
revealed that LIPUS treatment significantly reduced the
formation of new vessels and tubes (y=0.0039). These, Although a number of preclinical studies, like the ones
previously described, have shown considerable promise re-
garding the use of ADSC-therapy, more studies are needed.
Future studies can continue to work toward determining if
hADSCs are capable of being used for cell replacement and
better elucidate the mechanisms by which hADSCs work.

IV. ADIPOSE TISSUE AS A SOURCE FOR STEM
CELLS, source_sentence: What percentage of cases had malignant lesions?
sentences: Vedolizumab Monoclonal antibody anti «487 integrins, blocks gut homing of T lymphocytes

“These drugs are used as second line treatments for SR aGvHD, as reviewed by Penack et al. (11).
’Ruxolitinib has been recently approved by FDA as second line therapy for SR aGVHD.

TABLE 3 | Major drugs used as second line treatment of cGvHD and their mechanisms.

Drug* Major mechanisms identified

Cyclosporin A, tacrolimus Calcineurin inhibitors that block downstrem TCR signalling leading to NFAT regulated genes transcription; block T cells
activation, --- Page 4 ---
J. Clin. Med. 2024, 13, 7559

4 of 13

lesions were found in 59 cases (70.24%) and malignant lesions in 25 cases (29.76%). In DC
IV, benign lesions were found in 57 cases (81.4%) and malignant lesions in 13 cases (18.6%).
There were no statistically significant associations between gender (p = 0.76), BMI (p = 0.52),
and obesity (p = 0.76) and the presence of thyroid malignancy.

Table 1. Demographic and pathologic features of 521 patients who underwent surgery due to

thyroid nodules., MSCs showed that these exosomes induce angiogenesis in
endothelial cells via the activation of the NF«B pathway (141).
However, in another study exosomes derived from hypoxia-
preconditioned MSCs contributed to the attenuation of the
injury resulting from an ischemia/reperfusion episode via the
Wnt signaling pathway (142). Beyond that, hypoxia seems to
increase exosome secretion in general (141). Also, in a fat
graft model, co-transplantation of exosomes from hypoxia pre-
conditioned adipose-derived MSC improved vascularization and
graft survival (143) (see Table 5)., source_sentence: When is routine fine-needle aspiration biopsy (FS) recommended during thyroidectomy?
sentences: ing queries about its routine use due to the improved preoperative diagnosis. Nowadays, while the use of FS during thyroidectomy
has decreased, it is still used as an additional method for different purposes intraoperatively. FS may not always provide definitive
results. If FS will alter the surgical plan or extent, it should be applied. Routine FS is not recommended for evaluating thyroid nod-
ules. But in addition to FNAB, if FS results may change the operation plan or extent, they can be utilized. FS should not be applied, Approximately 15% of FNABs take part in this category.
After their initial Bethesda | FNAB, the malignancy risk in
nodules surgically excised, ranges between 5-20%. Repeat
FNAB is recommended if the initial FNAB result is Bethes-
da |, and in 60-80% of cases, the repeat FNAB results in a
diagnostic category.''?*°! If the second FNAB also yields a
nondiagnostic result, surgical resection is recommended.
21] Especially in cases with Bethesda | FNAB and with a sur-
gical indication, an intraoperative FS can be utilized.® It
has been reported that FS significantly contributes to the, Preconditioning with a myriad of other soluble factors, such
as growth factors or hormones, seems to also potentiate MSCs
regenerative capacity, mainly by stimulating angiogenesis and
inhibiting fibrosis. For example, intracardiac transplantation
of SDF-1-preconditioned MSCs increased angiogenesis and
reduced fibrosis in the ischemic area of a post-infarct heart (89).
The effects observed were attributed to the activation of the Akt
signaling pathway, similarly to what was described for hypoxia-
preconditioned MSCs. TGF-a-preconditioned MSCs enhanced, source_sentence: What is the number of genes obtained from comparing control and LIPUS-stimulated samples?
sentences: Differentially expressed genes (DEGs) were obtained
between control and LIPUS-stimulated samples using
an adjusted P<0.05 and|log2FC| > 1 as cutoffs to define
statistically significant differential expression. 676 genes
were obtained from which 578 were upregulated when
stimulated with LIPUS and 98 genes were subregulated
(Supp. Figure 1). To further understand the functions
and pathways associated with the differentially expressed
genes (DEG), Gene Ontology (GO) and Kyoto Encyclo-
pedia of Genes and Genomes (KEGG) analyses were con-
ducted using the DAVID database [37, 38]., Another advantage of ADSCs is their immune privilege
status due to a lack of major histocompatibility complex
II (MHC Il) and costimulatory molecules.42,43,45,.47 Some
studies have even demonstrated a higher immunosuppres-
sion capacity in ADSCs compared to BMSCs as ADSCs ex-
pressed lower levels of human antigen class I (HLA I) anti-
gen.47 They also have a unique secretome and can produce
immunomodulatory, anti-apoptotic, hematopoietic, and
angiogenic factors that can help with repair of tissues -
characteristics that may support successful transplanta-, independent studies have shown a raising trend in both cancer incidence [2] and a high-salt
dietary lifestyle [7], there is no direct correlation between dietary salt intake and breast
cancer. Interestingly, in the human body, certain organs such as the skin and lymph nodes
have a natural tendency to accumulate salt [8]. Although unknown, the pathophysiological
significance of this selective accumulation of sodium in certain organs and solid tumors is
an area of intense research.
pipeline_tag: sentence-similarity
library_name: sentence-transformers
metrics: cosine_accuracy
model-index: name: SentenceTransformer based on microsoft/mpnet-base
results: task: type: triplet
name: Triplet
dataset: name: initial test
type: initial_test
metrics: type: cosine_accuracy
value: 0.9800000190734863
name: Cosine Accuracy
verified: no, task: type: triplet
name: Triplet
dataset: name: final test
type: final_test
metrics: type: cosine_accuracy
value: 0.9800000190734863
name: Cosine Accuracy
verified: no
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Created: 2025-08-04 19:53:52