Model: christinemahler/aie5-midter-new
Author: christinemahler
Pipeline: sentence-similarity
Library: sentence-transformers
Tags: sentence-transformers, safetensors, bert, sentence-similarity, feature-extraction, generated_from_trainer, dataset_size:216, loss:MatryoshkaLoss, loss:MultipleNegativesRankingLoss, arxiv:1908.10084, arxiv:2205.13147, arxiv:1705.00652, base_model:Snowflake/snowflake-arctic-embed-l, base_model:finetune:Snowflake/snowflake-arctic-embed-l, model-index, text-embeddings-inference, endpoints_compatible, region:us
Base models (finetune): id: Snowflake/snowflake-arctic-embed-l
Card metadata: tags: sentence-transformers, sentence-similarity, feature-extraction, generated_from_trainer, dataset_size:216, loss:MatryoshkaLoss, loss:MultipleNegativesRankingLoss
base_model: Snowflake/snowflake-arctic-embed-l
widget: source_sentence: What types of organizations are eligible to apply for the PAR-25-353 opportunity titled "National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders"?
sentences: PAR-25-353: National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U19 Clinical Trial Optional) Section III. Eligibility Information
    
 
 
 
    1. Eligible Applicants
    
 
 
   Eligible Organizations
    
    Higher Education Institutions
    
 
 
     Public/State Controlled Institutions of Higher Education
     
 
     Private Institutions of Higher Education
     
 
 
    The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
    
 
 
     Hispanic-serving Institutions
     
 
     Historically Black Colleges and Universities (HBCUs)
     
 
     Tribally Controlled Colleges and Universities (TCCUs)
     
 
     Alaska Native and Native Hawaiian Serving Institutions
     
 
     Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
     
 
 
    Nonprofits Other Than Institutions of Higher Education
    
 
 
     Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
     
 
     Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
     
 
 
    For-Profit Organizations
    
 
 
     Small Businesses
     
 
     For-Profit Organizations (Other than Small Businesses)
     
 
 
    Local Governments
    
 
 
     State Governments
     
 
     County Governments
     
 
     City or Township Governments
     
 
     Special District Governments
     
 
     Indian/Native American Tribal Governments (Federally Recognized)
     
 
     Indian/Native American Tribal Governments (Other than Federally Recognized)
     
 
 
 
 
    Federal Governments
    
 
 
     Eligible Agencies of the Federal Government
     
 
     U.S. Territory or Possession
     
 
 
 
 
    Other
    
 
 
     Independent School Districts
     
 
     Public Housing Authorities/Indian Housing Authorities
     
 
     Native American Tribal Organizations (other than Federally recognized tribal governments)
     
 
     Faith-based or Community-based Organizations
     
 
     Regional Organizations
     
 
 
 
   Foreign Organizations
    
 
 
    Non-domestic (non-U.S.) Entities (Foreign Organization)
     
     are not
     
    eligible to apply.
    
 
 
 
    Non-domestic (non-U.S.) components of U.S. Organizations
     
     are not
     
    eligible to apply.
    
 
 
 
    Foreign components, as
     
     defined in the NIH Grants Policy Statement
     
    ,
     
     are
     
    allowed.
    
 
 
   Required Registrations
    
 
     Applicant organizations
     
 
 
    Applicant organizations must complete and maintain the following registrations as described in the
     
     How to Apply- Application Guide
     
    to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference
     
     NIH Grants Policy Statement Section 2.3.9.2 Electronically Submitted Applications
     
    for additional information.
    
 
 
 
      System for Award Management (SAM)
      
     – Applicants must complete and maintain an active registration,
      
      which requires renewal at least annually
      
     . The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code.
      
 
 
        NATO Commercial and Government Entity (NCAGE) Code
        
       – Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM.
       
 
       Unique Entity Identifier (UEI) - A UEI is issued as part of the SAM.gov registration process. The same UEI must be used for all registrations, as well as on the grant application.
       
 
 
 
 
      eRA Commons
      
     - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants.gov registration; all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application.
     
 
 
      Grants.gov
      
     – Applicants must have an active SAM registration in order to complete the Grants.gov registration.
     
 
 
 
     Program Directors/Principal Investigators (PD(s)/PI(s))
     
 
 
    All PD(s)/PI(s) must have an eRA Commons account.  PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.
    
 
 
   Eligible Individuals (Program Director/Principal Investigator)
    
    Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support.
    
 
    For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the
     
     How to Apply - Application Guide
     
    .
    
 
 
 
    An NIH intramural scientist may not serve as the PD/PI of an NCDDG but may participate as a research collaborator or consultant (see
     
 
 
     Section IV.7
     
 
 
    for more information).
    
 
 
 
    2. Cost Sharing
    
 
    This NOFO does not require cost sharing as defined in the
     
     NIH Grants Policy Statement
     
 
     Section 1.2- Definitions of Terms.
     
 
 
 
 
    3. Additional Information on Eligibility
    
 
    Number of Applications
    
 
 
 
    Applicant organizations may submit more than one application, provided that each application is scientifically distinct.
    
 
    The NIH will not accept duplicate or highly overlapping applications under review at the same time per
     
     NIH Grants Policy Statement Section 2.3.7.4 Submission of Resubmission Application
     
    . This means that the NIH will not accept:
    
 
 
     A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application.
     
 
     A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.
     
 
     An application that has substantial overlap with another application pending appeal of initial peer review (see
      
      NIH Grants Policy Statement 2.3.9.4 Similar, Essentially Identical, or Identical Applications
      
     )., RFA-DK-26-009: New Investigator Gateway Awards for Collaborative T1D Research (R03 Clinical Trial Not Allowed) Section VI. Award Administration Information
    
 
 
 
    1. Award Notices
    
 
    A Notice of Award (NoA) is the official authorizing document notifying the applicant that an award has been made and that funds may be requested from the designated HHS payment system or office. The NoA is signed by the Grants Management Officer and emailed to the recipient’s business official.
    
 
    In accepting the award, the recipient agrees that any activities under the award are subject to all provisions currently in effect or implemented during the period of the award, other Department regulations and policies in effect at the time of the award, and applicable statutory provisions.
    
 
    Recipients must comply with any funding restrictions described in
     
     Section IV.6. Funding Restrictions
     
    . Any pre-award costs incurred before receipt of the NoA are at the applicant's own risk.  For more information on the Notice of Award, please refer to the
     
     NIH Grants Policy Statement Section 5. The Notice of Award
     
    and NIH Grants & Funding website, see
     
     Award Process.
     
 
 
 
 
    Institutional Review Board or Independent Ethics Committee Approval: Recipient institutions must ensure that protocols are reviewed by their IRB or IEC. To help ensure the safety of participants enrolled in NIH-funded studies, the recipient must provide NIH copies of documents related to all major changes in the status of ongoing protocols.
    
 
 
 
    2. Administrative and National Policy Requirements
    
 
    The following Federal wide and HHS-specific policy requirements apply to awards funded through NIH:
    
 
 
     The rules listed at
      
      2 CFR Part 200
      
     , Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards.
     
 
     All NIH grant and cooperative agreement awards include the
      
      NIH Grants Policy Statement
      
     as part of the terms and conditions in the Notice of Award (NoA). The NoA includes the requirements of this NOFO. For these terms of award, see the
      
      NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: General
      
     and
      
      Part II: Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Recipients, and Activities
      
     .
     
 
     If a recipient receives an award, the recipient must follow all applicable nondiscrimination laws. The recipient agrees to this when registering in SAM.gov. The recipient must also submit an Assurance of Compliance (
      
      HHS-690
      
     ). To learn more, see the
      
      Laws and Regulations Enforced by the HHS Office for Civil Rights website
      
     .
      
 
       HHS recognizes that NIH research projects are often limited in scope for many reasons that are nondiscriminatory, such as the principal investigator’s scientific interest, funding limitations, recruitment requirements, and other considerations. Thus, criteria in research protocols that target or exclude certain populations are warranted where nondiscriminatory justifications establish that such criteria are appropriate with respect to the health or safety of the subjects, the scientific study design, or the purpose of the research. For additional guidance regarding how the provisions apply to NIH grant programs, please contact the Scientific/Research Contact that is identified in Section VII under Agency Contacts of this NOFO.
       
 
 
 
 
    All federal statutes and regulations relevant to federal financial assistance, including those highlighted in
     
     NIH Grants Policy Statement Section 4 Public Policy Requirements, Objectives and Other Appropriation Mandates.
     
 
 
    Recipients are responsible for ensuring that their activities comply with all applicable federal regulations.  NIH may terminate awards under certain circumstances.  See
     
     2 CFR Part 200.340 Termination
     
    and
     
     NIH Grants Policy Statement Section 8.5.2 Remedies for Noncompliance or Enforcement Actions: Suspension, Termination, and Withholding of Support
     
    .
    
 
    Successful recipients under this NOFO agree that:
    
 
    Where the award funding involves implementing, acquiring, or upgrading health IT for activities by any funded entity, recipients and subrecipient(s) are required to: Use health IT that meets standards and implementation specifications adopted in 45 CFR part 170, Subpart B, if such standards and implementation specifications can support the activity.  Visit
     
     https://www.ecfr.gov/current/title-45/subtitle-A/subchapter-D/part-170/subpart-B
     
    to learn more.
    
 
    Where the award funding involves implementing, acquiring, or upgrading health IT for activities by eligible clinicians in ambulatory settings, or hospitals, eligible under Sections 4101, 4102, and 4201 of the HITECH Act, use health IT certified under the ONC Health IT Certification Program if certified technology can support the activity. Visit
     
     https://www.healthit.gov/topic/certification-ehrs/certification-health-it
     
    to learn more.
    
 
    Pursuant to the Cybersecurity Act of 2015, Div. N, § 405, Pub. Law 114-113, 6 USC § 1533(d), the HHS Secretary has established a common set of voluntary, consensus-based, and industry-led guidelines, best practices, methodologies, procedures, and processes.
    
 
    Successful recipients under this NOFO agree that:
    
 
    When recipients, subrecipients, or third-party entities have:
    
 
 
     ongoing and consistent access to HHS owned or operated information or operational technology systems; and
     
 
     receive, maintain, transmit, store, access, exchange, process, or utilize personal identifiable information (PII) or personal health information (PHI) obtained from the awarding HHS agency for the purposes of executing the award.
     
 
 
    Recipients shall develop plans and procedures, modeled after the
     
     NIST Cybersecurity framework
     
    , to protect HHS systems and data. Please refer to
     
     NIH Post-Award Monitoring and Reporting
     
    for additional information.
    
 
 
   Cooperative Agreement Terms and Conditions of Award
    
    Not Applicable.
    
 
 
   3. Data Management and Sharing
    
    Consistent with the 2023 NIH Policy for Data Management and Sharing, when data management and sharing is applicable to the award, recipients will be required to adhere to the Data Management and Sharing requirements as outlined in the
     
     NIH Grants Policy Statement
     
    . Upon the approval of a Data Management and Sharing Plan, it is required for recipients to implement the plan as described.
    
 
 
 
    4. Reporting
    
 
    When multiple years are involved, recipients will be required to submit the
     
     Research Performance Progress Report (RPPR)
     
    annually and financial statements as required in the
     
     NIH Grants Policy Statement Section 8.4.1 Reporting.
     
    To learn more about post-award monitoring and reporting, see the NIH Grants & Funding website, see
     
     Post-Award Monitoring and Reporting
     
    .
    
 
 
 
    A final RPPR, invention statement, and the expenditure data portion of the Federal Financial Report are required for closeout of an award, as described in the
     
     NIH Grants Policy Statement Section 8.6 Closeout
     
    . NIH NOFOs outline intended research goals and objectives. Post award, NIH will review and measure performance based on the details and outcomes that are shared within the RPPR, as described at 2 CFR Part 200.301., RFA-HL-26-011: Leadership and Coordination Center (LACC) for the MACS/WIHS Combined Cohort Study (MWCCS) (U01 Clinical Trials Not Allowed) Section II. Award Information
    
 
 
   Funding Instrument
    
    Cooperative Agreement: A financial assistance mechanism used when there will be substantial Federal scientific or programmatic involvement. Substantial involvement means that, after award, NIH scientific or program staff will assist, guide, coordinate, or participate in project activities. See Section VI.2 for additional information about the substantial involvement for this NOFO.
    
 
 
   Application Types Allowed
   New
    
 
 
 
    The
     
     OER Glossary
     
    and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
    
 
 
   Clinical Trial?
    
    Not Allowed: Only accepting applications that do not propose clinical trials.
    
 
 
 
 
     Need help determining whether you are doing a clinical trial?
     
 
 
 
   Funds Available and Anticipated Number of Awards
    
    The following NIH components intend to commit an estimated total of $3 million to fund a single award in FY 2026:
    
 
    NHLBI, $1.37 million
    
 
    NIAID, $0.30 million
    
 
    NIMH, $0.30 million
    
 
    NCI, $0.35 million
    
 
    NIA, $0.19 million
    
 
    NIDA, $0.15 million
    
 
    NICHD, $0.13 million
    
 
    NIDCR, $0.07 million
    
 
    NIMHD, $0.04 million
    
 
    NIAAA, $0.03 million
    
 
    NINR, $0.03 million
    
 
    ORWH, $0.03 million
    
 
    NIDCD, $0.02 million
    
 
 
   Award Budget
    
    Application budgets may not exceed direct costs of $2 million per year in Fiscal Years 2026 through 2031.
    
 
 
   Award Project Period
    
    6 years
    
 This variable defines that we need to start a new row.  
 
 
 
    NIH grants policies as described in the
     
     NIH Grants Policy Statement
     
    will apply to the applications submitted and awards made from this NOFO., source_sentence: How does the title of opportunity ID [insert ID] align with the strategic goals of the Department of Health and Human Services?
sentences: Department of Health and Human Services, RFA-DK-26-007: Collaborative Research Using Biosamples and/or Data from Type 1 Diabetes Clinical Studies (R01 - Clinical Trial Not Allowed) Section II. Award Information
    
 
 
   Funding Instrument
    
    Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.
    
 
 
   Application Types Allowed
   New
    
   Resubmission - Resubmission applications from
    
    RFA-DK-22-021
    
   and from the current active NOFO RFA-DK-26-007 may be submitted in response to this NOFO.
    
 
 
 
    The
     
     OER Glossary
     
    and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
    
 
 
   Clinical Trial?
    
    Not Allowed: Only accepting applications that do not propose clinical trials.
    
 
 
 
 
     Need help determining whether you are doing a clinical trial?
     
 
 
 
   Funds Available and Anticipated Number of Awards
    
    NIDDK intends to commit $5.5 million in Fiscal Year 2026 to fund 3-4 awards and $5.5 million in FY 27 to fund 3-4 awards. The number of awards is contingent upon the submission of a sufficient number of meritorious applications.
    
 
 
   Award Budget
    
    Application budgets are limited to no more than $1,200,000 direct costs per year, exclusive of facilities and administrative (F&A) costs. Budgets are expected to reflect the actual needs of the proposed project.
    
 
 
   Award Project Period
    
    The maximum project period is 3 years.
    
 This variable defines that we need to start a new row.  
 
 
 
    NIH grants policies as described in the
     
     NIH Grants Policy Statement
     
    will apply to the applications submitted and awards made from this NOFO., RFA-DK-26-009: New Investigator Gateway Awards for Collaborative T1D Research (R03 Clinical Trial Not Allowed) Section IV. Application and Submission Information
    
 
 
 
    1. Requesting an Application Package
    
 
    The application forms package specific to this opportunity must be accessed through ASSIST, Grants.gov Workspace or an institutional system-to-system solution. Links to apply using ASSIST or Grants.gov Workspace are available in Part 1 of this NOFO. See your administrative office for instructions if you plan to use an institutional system-to-system solution.
    
 
 
 
    2. Content and Form of Application Submission
    
 
    It is critical that applicants follow the instructions in the Research (R) Instructions in the
     
     How to Apply - Application Guide
     
    except where instructed in this notice of funding opportunity to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
    
 
 
 
    Letter of Intent
    
 
    Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and plan the review.
    
 
    By the date listed in
     
     Part 1. Overview Information
     
    , prospective applicants are asked to submit a letter of intent that includes the following information:
    
 
 
     Descriptive title of proposed activity
     
 
     Name(s), address(es), and telephone number(s) of the PD(s)/PI(s)
     
 
     Names of other key personnel
     
 
     Participating institution(s)
     
 
     Number and title of this funding opportunity
     
 
 
    The letter of intent should be sent to:
    
 
    John Connaughton, Ph.D.
     
    Chief, Scientific Review Branch
     
    National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
     
    Telephone: 301-594-7797
     
    Email:
     
 
      [email protected]
      
 
 
 
 
 
    Page Limitations
    
 
    All page limitations described in the
     
     How to Apply- Application Guide
     
    and the
     
     Table of Page Limits
     
    must be followed.
    
 
 
   Instructions for Application Submission
    
    The following section supplements the instructions found in the
     
     How to Apply- Application Guide
     
    and should be used for preparing an application to this NOFO.
    
 
 
 
    SF424(R&R) Cover
    
 
    All instructions in the
     
 
      How to Apply - Application Guide
      
 
    must be followed.
    
 
 
 
    SF424(R&R) Project/Performance Site Locations
    
 
    All instructions in the How to Apply- Application Guide must be followed.
    
 
 
 
    SF424(R&R) Other Project Information
    
 
    All instructions in the How to Apply- Application Guide must be followed.
    
 
 
 
 
     Other Attachments:
     
 
 
 
     Proposed Affiliation Letter
     
    : Name the PDF formatted letter "Proposed_Affiliation_Ltr.pdf". Applications must include a one page letter that includes a brief statement identifying the specific NIDDK consortium or network that is within scope of the proposed aims. In addition, the applicant must outline in the letter how the objectives and design of the application are related to, but distinct from, ongoing studies in the consortium or network of interest, and describe how developing a relationship with the chosen consortium or network would be expected to facilitate the applicant's research and career goals. Applications that lack the proposed Affiliation Letter are considered incomplete and will not be peer reviewed.
    
 
 
 
    SF424(R&R) Senior/Key Person Profile
    
 
    All instructions in the How to Apply- Application Guide must be followed.
    
 
 
 
    R&R or Modular Budget
    
 
    All instructions in the How to Apply- Application Guide must be followed.
    
 
 
 
    Applicants should also follow these additional instructions:
    
 
    Applicants should budget for travel to one meeting of the proposed affiliated consortium or network per year. Except in unusual circumstances, only the PD/PI may be supported by R03 funds to travel to consortium meetings. There is no specific line item in which to list travel costs ($2000/year) in the modular budget format; instead, the proposed travel should be described in the budget justification section.
    
 
 
 
    R&R Subaward Budget
    
 
    All instructions in the How to Apply-Application Guide must be followed.
    
 
 
 
    PHS 398 Cover Page Supplement
    
 
    All instructions in the How to Apply- Application Guide must be followed.
    
 
 
 
    PHS 398 Research Plan
    
 
    All instructions in the How to Apply- Application Guide must be followed, with the following additional instructions:
    
 
 
 
 
     Resource Sharing Plan
     
    : Individuals are required to comply with the instructions for the Resource Sharing Plans as provided in the How to Apply- Application Guide.
    
 
 
 
 
     Protocol, tool and reagent sharing
     
    : The applicant should discuss plans for sharing and distribution of non-data resources that will be generated by the proposed project, including models, protocols, computational tools, biomaterials, and reagents. As one of the essential goals of the Gateway program is to support high impact advances, NIDDK intends that tools and reagents generated by the Gateway program will be made broadly available and distributed at minimal cost, and without undue intellectual property constraints, so that they can be as widely used as possible, thus enabling rapid downstream applications for the reagents by the larger scientific community. Applicants are expected to register resources supported by this NOFO with the NIDDK Information Network (dkNET) at
     
     https://dknet.org/
     
    and use Research Resource Identifiers (RRID) assigned through dkNET in any publication supported by this NOFO. Applicants should also be familiar with the NIH statements regarding intellectual property of resources developed with Federal funds
     
     (
     
    NIH Research Tools Policy (
     
 
      https://grants.nih.gov/grants/intell-property_64FR72090.pdf
      
 
    ) and other related NIH sharing policies at
     
 
      http://sharing.
      
     nih.gov
     
    .
    
 
 
 
 
     Other Plan(s):
     
 
 
    All instructions in the How to Apply-Application Guide must be followed, with the following additional instructions:
    
 
 
 
 
     All applicants planning research (funded or conducted in whole or in part by NIH) that results in the generation of scientific data are required to comply with the instructions for the Data Management and Sharing Plan.
     
 
 
 
 
 
     Appendix:
     
    Only limited Appendix materials are allowed. Follow all instructions for the Appendix as described in the How to Apply- Application Guide.
    
 
 
     No publications or other material, with the exception of blank questionnaires or blank surveys, may be included in the Appendix.
     
 
 
 
 
    PHS Human Subjects and Clinical Trials Information
    
 
    When involving human subjects research, clinical research, and/or NIH-defined clinical trials (and when applicable, clinical trials research experience) follow all instructions for the PHS Human Subjects and Clinical Trials Information form in the How to Apply- Application Guide, with the following additional instructions:
    
 
    If you answered “Yes” to the question “Are Human Subjects Involved?” on the R&R Other Project Information form, you must include at least one human subjects study record using the
     
     Study Record: PHS Human Subjects and Clinical Trials Information
     
    form or
     
     Delayed Onset Study
     
    record.
    
 
 
     Study Record: PHS Human Subjects and Clinical Trials Information
     
 
 
    All instructions in the How to Apply- Application Guide must be followed.
    
 
 
 
 
     Delayed Onset Study
     
 
 
    Note:
     
     Delayed onset
     
    does NOT apply to a study that can be described but will not start immediately (i.e., delayed start). All instructions in the How to Apply- Application Guide must be followed.
    
 
 
 
    PHS Assignment Request Form
    
 
    All instructions in the How to Apply- Application Guide must be followed.
    
 
 
 
    3. Unique Entity Identifier and System for Award Management (SAM)
    
 
    See Part 2. Section III.1 for information regarding the requirement for obtaining a unique entity identifier and for completing and maintaining active registrations in System for Award Management (SAM), NATO Commercial and Government Entity (NCAGE) Code (if applicable), eRA Commons, and Grants.gov
    
 
 
 
    4. Submission Dates and Times
    
 
    Part I. contains information about Key Dates and times. Applicants are encouraged to submit applications before the due date to ensure they have time to make any application corrections that might be necessary for successful submission. When a submission date falls on a weekend or
     
     Federal holiday
     
    , the application deadline is automatically extended to the next business day.
    
 
    Organizations must submit applications to
     
     Grants.gov
     
    (the online portal to find and apply for grants across all Federal agencies). Applicants must then complete the submission process by tracking the status of the application in the
     
     eRA Commons
     
    , NIH’s electronic system for grants administration. NIH and Grants.gov systems check the application against many of the application instructions upon submission. Errors must be corrected and a changed/corrected application must be submitted to Grants.gov on or before the application due date and time.  If a Changed/Corrected application is submitted after the deadline, the application will be considered late. Applications that miss the due date and time are subjected to the
     
     NIH Grants Policy Statement Section 2.3.9.2 Electronically Submitted Applications
     
    .
    
 
 
     Applicants are responsible for viewing their application before the due date in the eRA Commons to ensure accurate and successful submission.
     
 
 
    Information on the submission process and a definition of on-time submission are provided in the How to Apply-Application Guide.
    
 
 
 
    5. Intergovernmental Review (E.O. 12372)
    
 
    This initiative is not subject to
     
     intergovernmental review.
     
 
 
 
 
    6. Funding Restrictions
    
 
    All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the
     
     NIH Grants Policy Statement
     
    .
    
 
    Pre-award costs are allowable only as described in the
     
     NIH Grants Policy Statement Section 7.9.1 Selected Items of Cost.
     
 
 
 
   7. Other Submission Requirements and Information
    
    Applications must be submitted electronically following the instructions described in the How to Apply Application Guide. Paper applications will not be accepted.
    
 
    Applicants must complete all required registrations before the application due date. Section III. Eligibility Information contains information about registration.
    
 
    For assistance with your electronic application or for more information on the electronic submission process, visit
     
     How to Apply – Application Guide
     
    . If you encounter a system issue beyond your control that threatens your ability to complete the submission process on-time, you must follow the
     
     Dealing with System Issues
     
    guidance. For assistance with application submission, contact the Application Submission Contacts in Section VII.
    
 
 
     Important reminders:
     
 
 
    All PD(s)/PI(s) must include their eRA Commons ID in the Credential field of the Senior/Key Person Profile form
     
     .
     
    Failure to register in the Commons and to include a valid PD/PI Commons ID in the credential field will prevent the successful submission of an electronic application to NIH. See Section III of this NOFO for information on registration requirements.
    
 
    The applicant organization must ensure that the unique entity identifier provided on the application is the same identifier used in the organization’s profile in the eRA Commons and for the System for Award Management. Additional information may be found in the How to Apply Application Guide.
    
 
    See
     
     more tips
     
    for avoiding common errors.
    
 
 
 
    Upon receipt, applications will be evaluated for completeness and compliance with application instructions by the Center for Scientific Review and responsiveness by NIDDK.  Applications that are incomplete, non-compliant, and/or nonresponsive will not be reviewed.
    
 
 
   Mandatory Disclosure
    
    Recipients or subrecipients must submit any information related to violations of federal criminal law involving fraud, bribery, or gratuity violations potentially affecting the federal award. See Mandatory Disclosures,
     
     2 CFR 200.113
     
    and
     
     NIH Grants Policy Statement Section 4.1.35
     
    .
    
 
    Send written disclosures to the NIH Chief Grants Management Officer listed on the Notice of Award for the IC that funded the award and to the
     
     HHS Office of Inspector Grant Self Disclosure Program
     
    at
     
 
      [email protected]
      
 
    .
    
 
 
 
    Post Submission Materials
    
 
    Applicants are required to follow the instructions for post-submission materials, as described in
     
     the policy, source_sentence: What are the main objectives of the Leadership and Coordination Center (LACC) for the MACS/WIHS Combined Cohort Study (MWCCS) as outlined in opportunity id RFA-HL-26-011?
sentences: RFA-HL-26-011: Leadership and Coordination Center (LACC) for the MACS/WIHS Combined Cohort Study (MWCCS) (U01 Clinical Trials Not Allowed) Part 2. Full Text of Announcement, PAR-25-353: National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U19 Clinical Trial Optional) Section VIII. Other Information
    
 
 
 
    Recently issued trans-NIH
     
     policy notices
     
    may affect your application submission. A full list of policy notices published by NIH is provided in the
     
     NIH Guide for Grants and Contracts
     
    . All awards are subject to the terms and conditions, cost principles, and other considerations described in the
     
     NIH Grants Policy Statement
     
    .
    
 
 
   Authority and Regulations
    
    Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.
    
  end row  
 
 
 
 
    Weekly TOC for this Announcement
    
 
 
    NIH Funding Opportunities and Notices
    
 
 
 
 
 
 
 
 
 
 
 
 
  Department of Health
   
  and Human Services (HHS)
   
 
 
 
   NIH... Turning Discovery Into Health
    
    ®, PAR-25-353: National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U19 Clinical Trial Optional) Section III. Eligibility Information
    
 
 
 
    1. Eligible Applicants
    
 
 
   Eligible Organizations
    
    Higher Education Institutions
    
 
 
     Public/State Controlled Institutions of Higher Education
     
 
     Private Institutions of Higher Education
     
 
 
    The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
    
 
 
     Hispanic-serving Institutions
     
 
     Historically Black Colleges and Universities (HBCUs)
     
 
     Tribally Controlled Colleges and Universities (TCCUs)
     
 
     Alaska Native and Native Hawaiian Serving Institutions
     
 
     Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
     
 
 
    Nonprofits Other Than Institutions of Higher Education
    
 
 
     Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
     
 
     Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
     
 
 
    For-Profit Organizations
    
 
 
     Small Businesses
     
 
     For-Profit Organizations (Other than Small Businesses)
     
 
 
    Local Governments
    
 
 
     State Governments
     
 
     County Governments
     
 
     City or Township Governments
     
 
     Special District Governments
     
 
     Indian/Native American Tribal Governments (Federally Recognized)
     
 
     Indian/Native American Tribal Governments (Other than Federally Recognized)
     
 
 
 
 
    Federal Governments
    
 
 
     Eligible Agencies of the Federal Government
     
 
     U.S. Territory or Possession
     
 
 
 
 
    Other
    
 
 
     Independent School Districts
     
 
     Public Housing Authorities/Indian Housing Authorities
     
 
     Native American Tribal Organizations (other than Federally recognized tribal governments)
     
 
     Faith-based or Community-based Organizations
     
 
     Regional Organizations
     
 
 
 
   Foreign Organizations
    
 
 
    Non-domestic (non-U.S.) Entities (Foreign Organization)
     
     are not
     
    eligible to apply.
    
 
 
 
    Non-domestic (non-U.S.) components of U.S. Organizations
     
     are not
     
    eligible to apply.
    
 
 
 
    Foreign components, as
     
     defined in the NIH Grants Policy Statement
     
    ,
     
     are
     
    allowed.
    
 
 
   Required Registrations
    
 
     Applicant organizations
     
 
 
    Applicant organizations must complete and maintain the following registrations as described in the
     
     How to Apply- Application Guide
     
    to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference
     
     NIH Grants Policy Statement Section 2.3.9.2 Electronically Submitted Applications
     
    for additional information.
    
 
 
 
      System for Award Management (SAM)
      
     – Applicants must complete and maintain an active registration,
      
      which requires renewal at least annually
      
     . The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code.
      
 
 
        NATO Commercial and Government Entity (NCAGE) Code
        
       – Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM.
       
 
       Unique Entity Identifier (UEI) - A UEI is issued as part of the SAM.gov registration process. The same UEI must be used for all registrations, as well as on the grant application.
       
 
 
 
 
      eRA Commons
      
     - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants.gov registration; all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application.
     
 
 
      Grants.gov
      
     – Applicants must have an active SAM registration in order to complete the Grants.gov registration.
     
 
 
 
     Program Directors/Principal Investigators (PD(s)/PI(s))
     
 
 
    All PD(s)/PI(s) must have an eRA Commons account.  PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.
    
 
 
   Eligible Individuals (Program Director/Principal Investigator)
    
    Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support.
    
 
    For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the
     
     How to Apply - Application Guide
     
    .
    
 
 
 
    An NIH intramural scientist may not serve as the PD/PI of an NCDDG but may participate as a research collaborator or consultant (see
     
 
 
     Section IV.7
     
 
 
    for more information).
    
 
 
 
    2. Cost Sharing
    
 
    This NOFO does not require cost sharing as defined in the
     
     NIH Grants Policy Statement
     
 
     Section 1.2- Definitions of Terms.
     
 
 
 
 
    3. Additional Information on Eligibility
    
 
    Number of Applications
    
 
 
 
    Applicant organizations may submit more than one application, provided that each application is scientifically distinct.
    
 
    The NIH will not accept duplicate or highly overlapping applications under review at the same time per
     
     NIH Grants Policy Statement Section 2.3.7.4 Submission of Resubmission Application
     
    . This means that the NIH will not accept:
    
 
 
     A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application.
     
 
     A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.
     
 
     An application that has substantial overlap with another application pending appeal of initial peer review (see
      
      NIH Grants Policy Statement 2.3.9.4 Similar, Essentially Identical, or Identical Applications
      
     )., source_sentence: Can an organization submit multiple applications for the RFA-HL-26-011 opportunity, and what conditions must be met for these applications?
sentences: PAR-25-378: Intervention Research to Improve Native American Health (R34 Clinical Trial Optional) Section VI. Award Administration Information
    
 
 
 
    1. Award Notices
    
 
    A Notice of Award (NoA) is the official authorizing document notifying the applicant that an award has been made and that funds may be requested from the designated HHS payment system or office. The NoA is signed by the Grants Management Officer and emailed to the recipient’s business official.
    
 
    In accepting the award, the recipient agrees that any activities under the award are subject to all provisions currently in effect or implemented during the period of the award, other Department regulations and policies in effect at the time of the award, and applicable statutory provisions.
    
 
    Recipients must comply with any funding restrictions described in
     
     Section IV.6. Funding Restrictions
     
    . Any pre-award costs incurred before receipt of the NoA are at the applicant's own risk. For more information on the Notice of Award, please refer to the
     
     NIH Grants Policy Statement Section 5. The Notice of Award
     
    and NIH Grants & Funding website, see
     
     Award Process.
     
 
 
 
 
    Individual awards are based on the application submitted to, and as approved by, the NIH and are subject to the IC-specific terms and conditions identified in the NoA.
    
 
    ClinicalTrials.gov: If an award provides for one or more clinical trials. By law (Title VIII, Section 801 of Public Law 110-85), the "responsible party" must register and submit results information for certain “applicable clinical trials” on the ClinicalTrials.gov Protocol Registration and Results System Information Website (
     
     https://register.clinicaltrials.gov
     
    ). NIH expects registration and results reporting of all trials whether required under the law or not. For more information, see
     
     https://grants.nih.gov/policy/clinical-trials/reporting/index.htm
     
 
 
    Institutional Review Board or Independent Ethics Committee Approval: Recipient institutions must ensure that all protocols are reviewed by their IRB or IEC. To help ensure the safety of participants enrolled in NIH-funded studies, the recipient must provide NIH copies of documents related to all major changes in the status of ongoing protocols.
    
 
    Data and Safety Monitoring Requirements: The NIH policy for data and safety monitoring requires oversight and monitoring of all NIH-conducted or -supported human biomedical and behavioral intervention studies (clinical trials) to ensure the safety of participants and the validity and integrity of the data. Further information concerning these requirements is found at http://grants.nih.gov/grants/policy/hs/data_safety.htm and in the application instructions (SF424 (R&R) and PHS 398).
    
 
    Investigational New Drug or Investigational Device Exemption Requirements: Consistent with federal regulations, clinical research projects involving the use of investigational therapeutics, vaccines, or other medical interventions (including licensed products and devices for a purpose other than that for which they were licensed) in humans under a research protocol must be performed under a Food and Drug Administration (FDA) investigational new drug (IND) or investigational device exemption (IDE).
    
 
 
 
    2. Administrative and National Policy Requirements
    
 
    The following Federal wide and HHS-specific policy requirements apply to awards funded through NIH:
    
 
 
     The rules listed at
      
      2 CFR Part 200
      
     , Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards.
     
 
     All NIH grant and cooperative agreement awards include the
      
      NIH Grants Policy Statement
      
     as part of the terms and conditions in the Notice of Award (NoA). The NoA includes the requirements of this NOFO. For these terms of award, see the
      
      NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: General
      
     and
      
      Part II: Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Recipients, and Activities
      
     .
     
 
     If a recipient receives an award, the recipient must follow all applicable nondiscrimination laws. The recipient agrees to this when registering in SAM.gov. The recipient must also submit an Assurance of Compliance (
      
      HHS-690
      
     ). To learn more, see the
      
      Laws and Regulations Enforced by the HHS Office for Civil Rights website
      
     .
      
 
       HHS recognizes that NIH research projects are often limited in scope for many reasons that are nondiscriminatory, such as the principal investigator’s scientific interest, funding limitations, recruitment requirements, and other considerations. Thus, criteria in research protocols that target or exclude certain populations are warranted where nondiscriminatory justifications establish that such criteria are appropriate with respect to the health or safety of the subjects, the scientific study design, or the purpose of the research. For additional guidance regarding how the provisions apply to NIH grant programs, please contact the Scientific/Research Contact that is identified in Section VII under Agency Contacts of this NOFO.
       
 
 
 
 
    All federal statutes and regulations relevant to federal financial assistance, including those highlighted in
     
     NIH Grants Policy Statement Section 4 Public Policy Requirements, Objectives and Other Appropriation Mandates.
     
 
 
    Recipients are responsible for ensuring that their activities comply with all applicable federal regulations.  NIH may terminate awards under certain circumstances.  See
     
     2 CFR Part 200.340 Termination
     
    and
     
     NIH Grants Policy Statement Section 8.5.2 Remedies for Noncompliance or Enforcement Actions: Suspension, Termination, and Withholding of Support
     
    .
    
 
    Successful recipients under this NOFO agree that:
    
 
    Where the award funding involves implementing, acquiring, or upgrading health IT for activities by any funded entity, recipients and subrecipient(s) are required to: Use health IT that meets standards and implementation specifications adopted in 45 CFR part 170, Subpart B, if such standards and implementation specifications can support the activity.  Visit
     
     https://www.ecfr.gov/current/title-45/subtitle-A/subchapter-D/part-170/subpart-B
     
    to learn more.
    
 
    Where the award funding involves implementing, acquiring, or upgrading health IT for activities by eligible clinicians in ambulatory settings, or hospitals, eligible under Sections 4101, 4102, and 4201 of the HITECH Act, use health IT certified under the ONC Health IT Certification Program if certified technology can support the activity. Visit
     
     https://www.healthit.gov/topic/certification-ehrs/certification-health-it
     
    to learn more.
    
 
    Pursuant to the Cybersecurity Act of 2015, Div. N, § 405, Pub. Law 114-113, 6 USC § 1533(d), the HHS Secretary has established a common set of voluntary, consensus-based, and industry-led guidelines, best practices, methodologies, procedures, and processes.
    
 
    Successful recipients under this NOFO agree that:
    
 
    When recipients, subrecipients, or third-party entities have:
    
 
    1) ongoing and consistent access to HHS owned or operated information or operational technology systems; and
    
 
    2) receive, maintain, transmit, store, access, exchange, process, or utilize personal identifiable information (PII) or personal health information (PHI) obtained from the awarding HHS agency for the purposes of executing the award.
    
 
    Recipients shall develop plans and procedures, modeled after the
     
     NIST Cybersecurity framework
     
    , to protect HHS systems and data. Please refer to
     
     NIH Post-Award Monitoring and Reporting
     
    for additional information.
    
 
 
   Cooperative Agreement Terms and Conditions of Award
    
    Not Applicable
    
 
 
   3. Data Management and Sharing
    
    Consistent with the 2023 NIH Policy for Data Management and Sharing, when data management and sharing is applicable to the award, recipients will be required to adhere to the Data Management and Sharing requirements as outlined in the
     
     NIH Grants Policy Statement
     
    . Upon the approval of a Data Management and Sharing Plan, it is required for recipients to implement the plan as described.
    
 
 
 
    4. Reporting
    
 
    When multiple years are involved, recipients will be required to submit the
     
     Research Performance Progress Report (RPPR)
     
    annually and financial statements as required in the
     
     NIH Grants Policy Statement Section 8.4.1 Reporting.
     
    To learn more about post-award monitoring and reporting, see the NIH Grants & Funding website, see
     
     Post-Award Monitoring and Reporting
     
    .
    
 
 
 
    A final RPPR, invention statement, and the expenditure data portion of the Federal Financial Report are required for closeout of an award, as described in the
     
     NIH Grants Policy Statement Section 8.6 Closeout
     
    . NIH NOFOs outline intended research goals and objectives. Post award, NIH will review and measure performance based on the details and outcomes that are shared within the RPPR, as described at 2 CFR Part 200.301., PAR-25-378: Intervention Research to Improve Native American Health (R34 Clinical Trial Optional) Section II. Award Information
    
 
 
   Funding Instrument
    
    Grant: A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.
    
 
 
   Application Types Allowed
   New
    
   Resubmission
    
 
 
 
    The
     
     OER Glossary
     
    and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
    
 
 
   Clinical Trial?
    
    Optional: Accepting applications that either propose or do not propose clinical trial(s).
    
 
 
 
 
     Need help determining whether you are doing a clinical trial?
     
 
 
 
   Funds Available and Anticipated Number of Awards
    
    The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
    
 
 
   Award Budget
    
    Applicants may request direct costs of up to $450,000 for three years. Although variations from year to year are permissible, in no case may any year be more than $225,000 in direct costs, and total direct costs for the entire project period may not exceed $450,000.
    
 
 
   Award Project Period
    
    The scope of the proposed project should determine the project period. The maximum project period is 3 years.
    
 This variable defines that we need to start a new row.  
 
 
 
    NIH grants policies as described in the
     
     NIH Grants Policy Statement
     
    will apply to the applications submitted and awards made from this NOFO., RFA-HL-26-011: Leadership and Coordination Center (LACC) for the MACS/WIHS Combined Cohort Study (MWCCS) (U01 Clinical Trials Not Allowed) Section III. Eligibility Information
    
 
 
 
    1. Eligible Applicants
    
 
 
   Eligible Organizations
    
    Higher Education Institutions
    
 
 
     Public/State Controlled Institutions of Higher Education
     
 
     Private Institutions of Higher Education
     
 
 
    The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education:
    
 
 
     Hispanic-serving Institutions
     
 
     Historically Black Colleges and Universities (HBCUs)
     
 
     Tribally Controlled Colleges and Universities (TCCUs)
     
 
     Alaska Native and Native Hawaiian Serving Institutions
     
 
     Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
     
 
 
    Nonprofits Other Than Institutions of Higher Education
    
 
 
     Nonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)
     
 
     Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)
     
 
 
    For-Profit Organizations
    
 
 
     Small Businesses
     
 
     For-Profit Organizations (Other than Small Businesses)
     
 
 
    Local Governments
    
 
 
     State Governments
     
 
     County Governments
     
 
     City or Township Governments
     
 
     Special District Governments
     
 
     Indian/Native American Tribal Governments (Federally Recognized)
     
 
     Indian/Native American Tribal Governments (Other than Federally Recognized).
     
 
 
 
 
    Federal Governments
    
 
 
     Eligible Agencies of the Federal Government
     
 
     U.S. Territory or Possession
     
 
 
 
 
    Other
    
 
 
     Independent School Districts
     
 
     Public Housing Authorities/Indian Housing Authorities
     
 
     Native American Tribal Organizations (other than Federally recognized tribal governments)
     
 
     Faith-based or Community-based Organizations
     
 
     Regional Organizations
     
 
 
 
   Foreign Organizations
    
 
 
    Non-domestic (non-U.S.) Entities (Foreign Organizations)
     
     are not
     
    eligible to apply.
    
 
 
 
    Non-domestic (non-U.S.) components of U.S. Organizations
     
     are not
     
    eligible to apply.
    
 
 
 
    Foreign components, as
     
     defined in the NIH Grants Policy Statement
     
    ,
     
     are not
     
    allowed.
    
 
 
   Required Registrations
    
 
     Applicant Organizations
     
 
 
    Applicant organizations must complete and maintain the following registrations as described in the How to Apply- Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. Failure to complete registrations in advance of a due date is not a valid reason for a late submission, please reference the
     
     NIH Grants Policy Statement Section 2.3.9.2 Electronically Submitted Applications
     
    for additional information.
    
 
 
 
      System for Award Management (SAM) –
      
     Applicants must complete and maintain an active registration,
      
      which requires renewal at least annually
      
     . The renewal process may require as much time as the initial registration. SAM registration includes the assignment of a Commercial and Government Entity (CAGE) Code for domestic organizations which have not already been assigned a CAGE Code.
      
 
 
        NATO Commercial and Government Entity (NCAGE) Code
        
       – Foreign organizations must obtain an NCAGE code (in lieu of a CAGE code) in order to register in SAM.
       
 
       Unique Entity Identifier (UEI) - A UEI is issued as part of the SAM.gov registration process. The same UEI must be used for all registrations, as well as on the grant application.
       
 
 
 
 
      eRA Commons
      
     - Once the unique organization identifier is established, organizations can register with eRA Commons in tandem with completing their Grants.gov registrations; all registrations must be in place by time of submission. eRA Commons requires organizations to identify at least one Signing Official (SO) and at least one Program Director/Principal Investigator (PD/PI) account in order to submit an application.
     
 
 
      Grants.gov
      
     – Applicants must have an active SAM registration in order to complete the Grants.gov registration.
     
 
 
 
     Program Directors/Principal Investigators (PD(s)/PI(s))
     
 
 
    All PD(s)/PI(s) must have an eRA Commons account.  PD(s)/PI(s) should work with their organizational officials to either create a new account or to affiliate their existing account with the applicant organization in eRA Commons. If the PD/PI is also the organizational Signing Official, they must have two distinct eRA Commons accounts, one for each role. Obtaining an eRA Commons account can take up to 2 weeks.
    
 
 
   Eligible Individuals (Program Director/Principal Investigator)
    
    Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with their organization to develop an application for support.
    
 
    For institutions/organizations proposing multiple PDs/PIs, visit the Multiple Program Director/Principal Investigator Policy and submission details in the Senior/Key Person Profile (Expanded) Component of the How to Apply-Application Guide.
    
 
 
 
    A multiple PI (mPI) leadership structure is required. The LACC mPI team should include individuals with demonstrated deep knowledge of, and familiarity with, the MWCCS. In addition, the team should include at least one clinician with experience in clinical care of patients living with HIV and/or relevant comorbidities, as well as one or more individuals with epidemiologic cohort study leadership experience.Individuals may not apply to be an mPI of both the LACC and Data Analysis and Sharing Center (DASC) (
     
     RFA-HL-26-010
     
    ). Applications without an mPI leadership structure will be considered incomplete and will not proceed to peer review.
    
 
 
 
    2. Cost Sharing
    
 
    This NOFO does not require cost sharing as defined in the
     
     NIH Grants Policy Statement Section 1.2 Definition of Terms
     
    .
    
 
 
 
    3. Additional Information on Eligibility
    
 
    Number of Applications
    
 
 
 
    Applicant organizations may submit more than one application, provided that each application is scientifically distinct.
    
 
    The NIH will not accept duplicate or highly overlapping applications under review at the same time, per
     
     NIH Grants Policy Statement Section 2.3.7.4 Submission of Resubmission Application
     
    . This means that the NIH will not accept:
    
 
 
     A new (A0) application that is submitted before issuance of the summary statement from the review of an overlapping new (A0) or resubmission (A1) application.
     
 
     A resubmission (A1) application that is submitted before issuance of the summary statement from the review of the previous new (A0) application.
     
 
     An application that has substantial overlap with another application pending appeal of initial peer review (see
      
      NIH Grants Policy Statement 2.3.9.4 Similar, Essentially Identical, or Identical Applications
      
     )., source_sentence: What is the purpose of the funding opportunity RFA-DK-26-007 titled "Collaborative Research Using Biosamples and/or Data from Type 1 Diabetes Clinical Studies"?
sentences: Department of Health and Human Services, RFA-DK-26-007: Collaborative Research Using Biosamples and/or Data from Type 1 Diabetes Clinical Studies (R01 - Clinical Trial Not Allowed) Part 1. Overview Information
    
 
 
   Participating Organization(s)
    
    National Institutes of Health (
     
     NIH
     
    )
    
 
 
   Components of Participating Organizations
    
    National Institute of Diabetes and Digestive and Kidney Diseases (
     
     NIDDK
     
    )
     
 
     Office of The Director, National Institutes of Health (
      
      OD
      
     )
     
 
 
   Funding Opportunity Title
    
    Collaborative Research Using Biosamples and/or Data from Type 1 Diabetes Clinical Studies (R01 - Clinical Trial Not Allowed)
    
 
 
   Activity Code
    
 
     R01
     
    Research Project Grant
    
 
 
   Announcement Type
   Reissue of
    
    RFA-DK-22-021
    
 
 
 
   Related Notices
    
 
 
      April 4, 2024
      
     - Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025. See Notice
      
      NOT-OD-24-084
      
     .
     
 
 
      August 31, 2022
      
     - Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice
      
      NOT-OD-22-198
      
     .
     
 
 
      August 5, 2022
      
     - Implementation Details for the NIH Data Management and Sharing Policy. See Notice
      
      NOT-OD-22-189
      
     .
     
 
 
 
   Funding Opportunity Number (FON)
    
    RFA-DK-26-007
    
 
 
   Companion Funding Opportunity
   None
    
 
   Number of Applications
    
    See
     
     Section III. 3. Additional Information on Eligibility
     
    .
    
 
 
   Assistance Listing Number(s)
   93.847
    
 
   Funding Opportunity Purpose
    
    This Notice of Funding Opportunity (NOFO) invites applications for studies of type 1 diabetes etiology and pathogenesis using data and samples from clinical trials and studies. This opportunity is intended to fund investigative teams collaborating to answer important questions about disease mechanisms leading to improved delay and durable prevention of type 1 diabetes. This NOFO is associated with the Special Diabetes Program (
     
     https://www.niddk.nih.gov/about-niddk/research-areas/diabetes/type-1-diabetes-special-statutory-funding-program/about-special-diabetes-program
     
    ) which funds research on the prevention, treatment, and cure of type 1 diabetes and its complications, including unique, innovative, and collaborative research consortia and clinical trials networks.
    
 
 
 
 
 
 
   Funding Opportunity Goal(s)
    
    To promote extramural basic and clinical biomedical research that improves the understanding of the mechanisms underlying disease and leads to improved preventions, diagnosis, and treatment of diabetes, digestive, and kidney diseases. Programmatic areas within the National Institute of Diabetes and Digestive and Kidney Diseases include diabetes, digestive, endocrine, hematologic, liver, metabolic, nephrologic, nutrition, obesity, and urologic diseases.
    
 This variable defines that we need to start a new row., RFA-DK-26-007: Collaborative Research Using Biosamples and/or Data from Type 1 Diabetes Clinical Studies (R01 - Clinical Trial Not Allowed) Part 1. Overview Information
    
 
 
   Participating Organization(s)
    
    National Institutes of Health (
     
     NIH
     
    )
    
 
 
   Components of Participating Organizations
    
    National Institute of Diabetes and Digestive and Kidney Diseases (
     
     NIDDK
     
    )
     
 
     Office of The Director, National Institutes of Health (
      
      OD
      
     )
     
 
 
   Funding Opportunity Title
    
    Collaborative Research Using Biosamples and/or Data from Type 1 Diabetes Clinical Studies (R01 - Clinical Trial Not Allowed)
    
 
 
   Activity Code
    
 
     R01
     
    Research Project Grant
    
 
 
   Announcement Type
   Reissue of
    
    RFA-DK-22-021
    
 
 
 
   Related Notices
    
 
 
      April 4, 2024
      
     - Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025. See Notice
      
      NOT-OD-24-084
      
     .
     
 
 
      August 31, 2022
      
     - Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice
      
      NOT-OD-22-198
      
     .
     
 
 
      August 5, 2022
      
     - Implementation Details for the NIH Data Management and Sharing Policy. See Notice
      
      NOT-OD-22-189
      
     .
     
 
 
 
   Funding Opportunity Number (FON)
    
    RFA-DK-26-007
    
 
 
   Companion Funding Opportunity
   None
    
 
   Number of Applications
    
    See
     
     Section III. 3. Additional Information on Eligibility
     
    .
    
 
 
   Assistance Listing Number(s)
   93.847
    
 
   Funding Opportunity Purpose
    
    This Notice of Funding Opportunity (NOFO) invites applications for studies of type 1 diabetes etiology and pathogenesis using data and samples from clinical trials and studies. This opportunity is intended to fund investigative teams collaborating to answer important questions about disease mechanisms leading to improved delay and durable prevention of type 1 diabetes. This NOFO is associated with the Special Diabetes Program (
     
     https://www.niddk.nih.gov/about-niddk/research-areas/diabetes/type-1-diabetes-special-statutory-funding-program/about-special-diabetes-program
     
    ) which funds research on the prevention, treatment, and cure of type 1 diabetes and its complications, including unique, innovative, and collaborative research consortia and clinical trials networks.
    
 
 
 
 
 
 
   Funding Opportunity Goal(s)
    
    To promote extramural basic and clinical biomedical research that improves the understanding of the mechanisms underlying disease and leads to improved preventions, diagnosis, and treatment of diabetes, digestive, and kidney diseases. Programmatic areas within the National Institute of Diabetes and Digestive and Kidney Diseases include diabetes, digestive, endocrine, hematologic, liver, metabolic, nephrologic, nutrition, obesity, and urologic diseases.
    
 This variable defines that we need to start a new row.
pipeline_tag: sentence-similarity
library_name: sentence-transformers
metrics: cosine_accuracy@1, cosine_accuracy@3, cosine_accuracy@5, cosine_accuracy@10, cosine_precision@1, cosine_precision@3, cosine_precision@5, cosine_precision@10, cosine_recall@1, cosine_recall@3, cosine_recall@5, cosine_recall@10, cosine_ndcg@10, cosine_mrr@10, cosine_map@100
model-index: name: SentenceTransformer based on Snowflake/snowflake-arctic-embed-l
results: task: type: information-retrieval
name: Information Retrieval
dataset: name: Unknown
type: unknown
metrics: type: cosine_accuracy@1
value: 0.875
name: Cosine Accuracy@1
verified: no, type: cosine_accuracy@3
value: 1
name: Cosine Accuracy@3
verified: no, type: cosine_accuracy@5
value: 1
name: Cosine Accuracy@5
verified: no, type: cosine_accuracy@10
value: 1
name: Cosine Accuracy@10
verified: no, type: cosine_precision@1
value: 0.875
name: Cosine Precision@1
verified: no, type: cosine_precision@3
value: 0.3333333333333333
name: Cosine Precision@3
verified: no, type: cosine_precision@5
value: 0.20000000000000004
name: Cosine Precision@5
verified: no, type: cosine_precision@10
value: 0.10000000000000002
name: Cosine Precision@10
verified: no, type: cosine_recall@1
value: 0.875
name: Cosine Recall@1
verified: no, type: cosine_recall@3
value: 1
name: Cosine Recall@3
verified: no, type: cosine_recall@5
value: 1
name: Cosine Recall@5
verified: no, type: cosine_recall@10
value: 1
name: Cosine Recall@10
verified: no, type: cosine_ndcg@10
value: 0.9484108127976215
name: Cosine Ndcg@10
verified: no, type: cosine_mrr@10
value: 0.9305555555555555
name: Cosine Mrr@10
verified: no, type: cosine_map@100
value: 0.9305555555555555
name: Cosine Map@100
verified: no
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Created: 2025-02-25 05:16:01