Model: potsu-potsu/pubmedbert-base-mrl
Author: potsu-potsu
Pipeline: sentence-similarity
Library: sentence-transformers
Tags: sentence-transformers, safetensors, bert, sentence-similarity, feature-extraction, generated_from_trainer, dataset_size:4012, loss:MatryoshkaLoss, loss:MultipleNegativesRankingLoss, en, arxiv:1908.10084, arxiv:2205.13147, arxiv:1705.00652, license:apache-2.0, model-index, text-embeddings-inference, endpoints_compatible, region:us
Card metadata: language: en
license: apache-2.0
tags: sentence-transformers, sentence-similarity, feature-extraction, generated_from_trainer, dataset_size:4012, loss:MatryoshkaLoss, loss:MultipleNegativesRankingLoss
widget: source_sentence: Do cephalopods use RNA editing less frequently than other species?
sentences: Extensive messenger RNA editing generates transcript and protein diversity in genes involved in neural excitability, as previously described, as well as in genes participating in a broad range of other cellular functions. , GV1001 is a 16-amino-acid vaccine peptide derived from the human telomerase reverse transcriptase sequence. It has been developed as a vaccine against various cancers., Using acetyl-specific K516 antibodies, we show that acetylation of endogenous S6K1 at this site is potently induced upon growth factor stimulation. We propose that K516 acetylation may serve to modulate important kinase-independent functions of S6K1 in response to growth factor signalling. Following mitogen stimulation, S6Ks interact with the p300 and p300/CBP-associated factor (PCAF) acetyltransferases. S6Ks can be acetylated by p300 and PCAF in vitro and S6K acetylation is detected in cells expressing p300, source_sentence: Can pets affect infant microbiomed?
sentences: Yes, exposure to household furry pets influences the gut microbiota of infants., Thiazovivin is a selective small molecule that directly targets Rho-associated kinase (ROCK) and increases expression of pluripotency factors.,  Here, we present evidence that the calcium/calmodulin-dependent protein kinase IV (CaMK4) is increased and required during Th17 cell differentiation. Inhibition of CaMK4 reduced Il17 transcription through decreased activation of the cAMP response element modulator a (CREM-a) and reduced activation of the AKT/mTOR pathway, which is known to enhance Th17 differentiation. CAMK4 knockdown and kinase-dead mutant inhibited crocin-mediated HO-1 expression, Nrf2 activation, and phosphorylation of Akt, indicating that HO-1 expression is mediated by CAMK4 and that Akt is a downstream mediator of CAMK4 in crocin signaling, source_sentence: In what proportion of children with heart failure has Enalapril been shown to be safe and effective?
sentences: 5-HT2A (5-hydroxytryptamine type 2a) receptor can be evaluated with the [18F]altanserin., In children with heart failure evidence of the effect of enalapril is empirical. Enalapril was clinically safe and effective in 50% to 80% of for children with cardiac failure secondary to congenital heart malformations before and after cardiac surgery,  impaired ventricular function , valvar regurgitation,  congestive cardiomyopathy,  , arterial hypertension, life-threatening arrhythmias coexisting with circulatory insufficiency.   
ACE inhibitors have shown a transient beneficial effect on heart failure due to anticancer drugs and possibly a beneficial effect in muscular dystrophy-associated cardiomyopathy, which deserves further studies., necroptosis
apoptosis  
pro-survival/inflammation NF-κB activation, source_sentence: How are SAHFS created?
sentences: In particular, up to 17% of neutrophil nuclei of healthy women exhibit a drumstick-shaped appendage that contains the inactive X chromosome., miR-1, miR-133, miR-208a, miR-206, miR-494, miR-146a, miR-222, miR-21, miR-221, miR-20a, miR-133a, miR-133b, miR-23, miR-107 and miR-181 are involved in exercise adaptation, Cellular senescence-associated heterochromatic foci (SAHFS) are a novel type of chromatin condensation involving alterations of linker histone H1 and linker DNA-binding proteins. SAHFS can be formed by a variety of cell types, but their mechanism of action remains unclear., source_sentence: What are the effects of the deletion of all three Pcdh clusters (tricluster deletion) in mice?
sentences: Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly. The vertebrate clustered protocadherin (Pcdh) cell surface proteins are encoded by three closely linked gene clusters (Pcdhα, Pcdhβ, and Pcdhγ). Although deletion of individual Pcdh clusters had subtle phenotypic consequences, the loss of all three clusters (tricluster deletion) led to a severe axonal arborization defect and loss of self-avoidance., The myocyte enhancer factor-2 (MEF2) proteins are MADS-box transcription factors that are essential for differentiation of all muscle lineages but their mechanisms of action remain largely undefined. MEF2C expression initiates cardiomyogenesis, resulting in the up-regulation of Brachyury T, bone morphogenetic protein-4, Nkx2-5, GATA-4, cardiac alpha-actin, and myosin heavy chain expression. Inactivation of the MEF2C gene causes cardiac developmental arrest and severe downregulation of a number of cardiac markers including atrial natriuretic factor (ANF). BMP-2, a regulator of cardiac development during embryogenesis, was shown to increase PI 3-kinase activity in cardiac precursor cells, resulting in increased expression of sarcomeric myosin heavy chain (MHC) and MEF-2A. Furthermore, expression of MEF-2A increased MHC expression in a PI 3-kinase-dependent manner. Other studies showed that Gli2 and MEF2C proteins form a complex, capable of synergizing on cardiomyogenesis-related promoters. Dominant interference of calcineurin/mAKAP binding blunts the increase in MEF2 transcriptional activity seen during myoblast differentiation, as well as the expression of endogenous MEF2-target genes. These findings show that MEF-2 can direct early stages of cell differentiation into a cardiomyogenic pathway., Investigators proposed that there have been three extended periods in the evolution of gene regulatory elements. Early vertebrate evolution was characterized by regulatory gains near transcription factors and developmental genes, but this trend was replaced by innovations near extracellular signaling genes, and then innovations near posttranslational protein modifiers.
pipeline_tag: sentence-similarity
library_name: sentence-transformers
metrics: cosine_accuracy@1, cosine_accuracy@3, cosine_accuracy@5, cosine_accuracy@10, cosine_precision@1, cosine_precision@3, cosine_precision@5, cosine_precision@10, cosine_recall@1, cosine_recall@3, cosine_recall@5, cosine_recall@10, cosine_ndcg@10, cosine_mrr@10, cosine_map@100
model-index: name: Biomedical MRL
results: task: type: information-retrieval
name: Information Retrieval
dataset: name: dim 768
type: dim_768
metrics: type: cosine_accuracy@1
value: 0.8062234794908062
name: Cosine Accuracy@1
verified: no, type: cosine_accuracy@3
value: 0.9292786421499293
name: Cosine Accuracy@3
verified: no, type: cosine_accuracy@5
value: 0.9533239038189534
name: Cosine Accuracy@5
verified: no, type: cosine_accuracy@10
value: 0.9660537482319661
name: Cosine Accuracy@10
verified: no, type: cosine_precision@1
value: 0.8062234794908062
name: Cosine Precision@1
verified: no, type: cosine_precision@3
value: 0.30975954738330974
name: Cosine Precision@3
verified: no, type: cosine_precision@5
value: 0.1906647807637906
name: Cosine Precision@5
verified: no, type: cosine_precision@10
value: 0.09660537482319659
name: Cosine Precision@10
verified: no, type: cosine_recall@1
value: 0.8062234794908062
name: Cosine Recall@1
verified: no, type: cosine_recall@3
value: 0.9292786421499293
name: Cosine Recall@3
verified: no, type: cosine_recall@5
value: 0.9533239038189534
name: Cosine Recall@5
verified: no, type: cosine_recall@10
value: 0.9660537482319661
name: Cosine Recall@10
verified: no, type: cosine_ndcg@10
value: 0.8940734682586426
name: Cosine Ndcg@10
verified: no, type: cosine_mrr@10
value: 0.8700764464201525
name: Cosine Mrr@10
verified: no, type: cosine_map@100
value: 0.8709063298425341
name: Cosine Map@100
verified: no, task: type: information-retrieval
name: Information Retrieval
dataset: name: dim 512
type: dim_512
metrics: type: cosine_accuracy@1
value: 0.809052333804809
name: Cosine Accuracy@1
verified: no, type: cosine_accuracy@3
value: 0.9292786421499293
name: Cosine Accuracy@3
verified: no, type: cosine_accuracy@5
value: 0.9519094766619519
name: Cosine Accuracy@5
verified: no, type: cosine_accuracy@10
value: 0.9660537482319661
name: Cosine Accuracy@10
verified: no, type: cosine_precision@1
value: 0.809052333804809
name: Cosine Precision@1
verified: no, type: cosine_precision@3
value: 0.30975954738330974
name: Cosine Precision@3
verified: no, type: cosine_precision@5
value: 0.19038189533239033
name: Cosine Precision@5
verified: no, type: cosine_precision@10
value: 0.09660537482319659
name: Cosine Precision@10
verified: no, type: cosine_recall@1
value: 0.809052333804809
name: Cosine Recall@1
verified: no, type: cosine_recall@3
value: 0.9292786421499293
name: Cosine Recall@3
verified: no, type: cosine_recall@5
value: 0.9519094766619519
name: Cosine Recall@5
verified: no, type: cosine_recall@10
value: 0.9660537482319661
name: Cosine Recall@10
verified: no, type: cosine_ndcg@10
value: 0.8941424934364455
name: Cosine Ndcg@10
verified: no, type: cosine_mrr@10
value: 0.8702515659729241
name: Cosine Mrr@10
verified: no, type: cosine_map@100
value: 0.8710899601617035
name: Cosine Map@100
verified: no, task: type: information-retrieval
name: Information Retrieval
dataset: name: dim 256
type: dim_256
metrics: type: cosine_accuracy@1
value: 0.801980198019802
name: Cosine Accuracy@1
verified: no, type: cosine_accuracy@3
value: 0.9207920792079208
name: Cosine Accuracy@3
verified: no, type: cosine_accuracy@5
value: 0.9519094766619519
name: Cosine Accuracy@5
verified: no, type: cosine_accuracy@10
value: 0.9632248939179632
name: Cosine Accuracy@10
verified: no, type: cosine_precision@1
value: 0.801980198019802
name: Cosine Precision@1
verified: no, type: cosine_precision@3
value: 0.3069306930693069
name: Cosine Precision@3
verified: no, type: cosine_precision@5
value: 0.19038189533239033
name: Cosine Precision@5
verified: no, type: cosine_precision@10
value: 0.09632248939179631
name: Cosine Precision@10
verified: no, type: cosine_recall@1
value: 0.801980198019802
name: Cosine Recall@1
verified: no, type: cosine_recall@3
value: 0.9207920792079208
name: Cosine Recall@3
verified: no, type: cosine_recall@5
value: 0.9519094766619519
name: Cosine Recall@5
verified: no, type: cosine_recall@10
value: 0.9632248939179632
name: Cosine Recall@10
verified: no, type: cosine_ndcg@10
value: 0.8888633341416707
name: Cosine Ndcg@10
verified: no, type: cosine_mrr@10
value: 0.8641695291978178
name: Cosine Mrr@10
verified: no, type: cosine_map@100
value: 0.8651249924605939
name: Cosine Map@100
verified: no, task: type: information-retrieval
name: Information Retrieval
dataset: name: dim 128
type: dim_128
metrics: type: cosine_accuracy@1
value: 0.7878359264497878
name: Cosine Accuracy@1
verified: no, type: cosine_accuracy@3
value: 0.9123055162659123
name: Cosine Accuracy@3
verified: no, type: cosine_accuracy@5
value: 0.9405940594059405
name: Cosine Accuracy@5
verified: no, type: cosine_accuracy@10
value: 0.9575671852899575
name: Cosine Accuracy@10
verified: no, type: cosine_precision@1
value: 0.7878359264497878
name: Cosine Precision@1
verified: no, type: cosine_precision@3
value: 0.3041018387553041
name: Cosine Precision@3
verified: no, type: cosine_precision@5
value: 0.1881188118811881
name: Cosine Precision@5
verified: no, type: cosine_precision@10
value: 0.09575671852899574
name: Cosine Precision@10
verified: no, type: cosine_recall@1
value: 0.7878359264497878
name: Cosine Recall@1
verified: no, type: cosine_recall@3
value: 0.9123055162659123
name: Cosine Recall@3
verified: no, type: cosine_recall@5
value: 0.9405940594059405
name: Cosine Recall@5
verified: no, type: cosine_recall@10
value: 0.9575671852899575
name: Cosine Recall@10
verified: no, type: cosine_ndcg@10
value: 0.8776845224261977
name: Cosine Ndcg@10
verified: no, type: cosine_mrr@10
value: 0.8513476347634764
name: Cosine Mrr@10
verified: no, type: cosine_map@100
value: 0.8524929782022361
name: Cosine Map@100
verified: no, task: type: information-retrieval
name: Information Retrieval
dataset: name: dim 64
type: dim_64
metrics: type: cosine_accuracy@1
value: 0.7609618104667609
name: Cosine Accuracy@1
verified: no, type: cosine_accuracy@3
value: 0.884016973125884
name: Cosine Accuracy@3
verified: no, type: cosine_accuracy@5
value: 0.9123055162659123
name: Cosine Accuracy@5
verified: no, type: cosine_accuracy@10
value: 0.9377652050919377
name: Cosine Accuracy@10
verified: no, type: cosine_precision@1
value: 0.7609618104667609
name: Cosine Precision@1
verified: no, type: cosine_precision@3
value: 0.29467232437529467
name: Cosine Precision@3
verified: no, type: cosine_precision@5
value: 0.18246110325318246
name: Cosine Precision@5
verified: no, type: cosine_precision@10
value: 0.09377652050919376
name: Cosine Precision@10
verified: no, type: cosine_recall@1
value: 0.7609618104667609
name: Cosine Recall@1
verified: no, type: cosine_recall@3
value: 0.884016973125884
name: Cosine Recall@3
verified: no, type: cosine_recall@5
value: 0.9123055162659123
name: Cosine Recall@5
verified: no, type: cosine_recall@10
value: 0.9377652050919377
name: Cosine Recall@10
verified: no, type: cosine_ndcg@10
value: 0.8544495237634239
name: Cosine Ndcg@10
verified: no, type: cosine_mrr@10
value: 0.8271598078175169
name: Cosine Mrr@10
verified: no, type: cosine_map@100
value: 0.8287981789570508
name: Cosine Map@100
verified: no
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Created: 2025-06-10 16:45:36