Model: potsu-potsu/medembed-sm-mrl
Author: potsu-potsu
Pipeline: sentence-similarity
Library: sentence-transformers
Tags: sentence-transformers, safetensors, bert, sentence-similarity, feature-extraction, generated_from_trainer, dataset_size:4012, loss:MatryoshkaLoss, loss:MultipleNegativesRankingLoss, en, arxiv:1908.10084, arxiv:2205.13147, arxiv:1705.00652, license:apache-2.0, model-index, text-embeddings-inference, endpoints_compatible, region:us
Card metadata: language: en
license: apache-2.0
tags: sentence-transformers, sentence-similarity, feature-extraction, generated_from_trainer, dataset_size:4012, loss:MatryoshkaLoss, loss:MultipleNegativesRankingLoss
widget: source_sentence: Do cephalopods use RNA editing less frequently than other species?
sentences: Extensive messenger RNA editing generates transcript and protein diversity in genes involved in neural excitability, as previously described, as well as in genes participating in a broad range of other cellular functions. , GV1001 is a 16-amino-acid vaccine peptide derived from the human telomerase reverse transcriptase sequence. It has been developed as a vaccine against various cancers., Using acetyl-specific K516 antibodies, we show that acetylation of endogenous S6K1 at this site is potently induced upon growth factor stimulation. We propose that K516 acetylation may serve to modulate important kinase-independent functions of S6K1 in response to growth factor signalling. Following mitogen stimulation, S6Ks interact with the p300 and p300/CBP-associated factor (PCAF) acetyltransferases. S6Ks can be acetylated by p300 and PCAF in vitro and S6K acetylation is detected in cells expressing p300, source_sentence: Can pets affect infant microbiomed?
sentences: Yes, exposure to household furry pets influences the gut microbiota of infants., Thiazovivin is a selective small molecule that directly targets Rho-associated kinase (ROCK) and increases expression of pluripotency factors.,  Here, we present evidence that the calcium/calmodulin-dependent protein kinase IV (CaMK4) is increased and required during Th17 cell differentiation. Inhibition of CaMK4 reduced Il17 transcription through decreased activation of the cAMP response element modulator a (CREM-a) and reduced activation of the AKT/mTOR pathway, which is known to enhance Th17 differentiation. CAMK4 knockdown and kinase-dead mutant inhibited crocin-mediated HO-1 expression, Nrf2 activation, and phosphorylation of Akt, indicating that HO-1 expression is mediated by CAMK4 and that Akt is a downstream mediator of CAMK4 in crocin signaling, source_sentence: In what proportion of children with heart failure has Enalapril been shown to be safe and effective?
sentences: 5-HT2A (5-hydroxytryptamine type 2a) receptor can be evaluated with the [18F]altanserin., In children with heart failure evidence of the effect of enalapril is empirical. Enalapril was clinically safe and effective in 50% to 80% of for children with cardiac failure secondary to congenital heart malformations before and after cardiac surgery,  impaired ventricular function , valvar regurgitation,  congestive cardiomyopathy,  , arterial hypertension, life-threatening arrhythmias coexisting with circulatory insufficiency.   
ACE inhibitors have shown a transient beneficial effect on heart failure due to anticancer drugs and possibly a beneficial effect in muscular dystrophy-associated cardiomyopathy, which deserves further studies., necroptosis
apoptosis  
pro-survival/inflammation NF-κB activation, source_sentence: How are SAHFS created?
sentences: In particular, up to 17% of neutrophil nuclei of healthy women exhibit a drumstick-shaped appendage that contains the inactive X chromosome., miR-1, miR-133, miR-208a, miR-206, miR-494, miR-146a, miR-222, miR-21, miR-221, miR-20a, miR-133a, miR-133b, miR-23, miR-107 and miR-181 are involved in exercise adaptation, Cellular senescence-associated heterochromatic foci (SAHFS) are a novel type of chromatin condensation involving alterations of linker histone H1 and linker DNA-binding proteins. SAHFS can be formed by a variety of cell types, but their mechanism of action remains unclear., source_sentence: What are the effects of the deletion of all three Pcdh clusters (tricluster deletion) in mice?
sentences: Multicluster Pcdh diversity is required for mouse olfactory neural circuit assembly. The vertebrate clustered protocadherin (Pcdh) cell surface proteins are encoded by three closely linked gene clusters (Pcdhα, Pcdhβ, and Pcdhγ). Although deletion of individual Pcdh clusters had subtle phenotypic consequences, the loss of all three clusters (tricluster deletion) led to a severe axonal arborization defect and loss of self-avoidance., The myocyte enhancer factor-2 (MEF2) proteins are MADS-box transcription factors that are essential for differentiation of all muscle lineages but their mechanisms of action remain largely undefined. MEF2C expression initiates cardiomyogenesis, resulting in the up-regulation of Brachyury T, bone morphogenetic protein-4, Nkx2-5, GATA-4, cardiac alpha-actin, and myosin heavy chain expression. Inactivation of the MEF2C gene causes cardiac developmental arrest and severe downregulation of a number of cardiac markers including atrial natriuretic factor (ANF). BMP-2, a regulator of cardiac development during embryogenesis, was shown to increase PI 3-kinase activity in cardiac precursor cells, resulting in increased expression of sarcomeric myosin heavy chain (MHC) and MEF-2A. Furthermore, expression of MEF-2A increased MHC expression in a PI 3-kinase-dependent manner. Other studies showed that Gli2 and MEF2C proteins form a complex, capable of synergizing on cardiomyogenesis-related promoters. Dominant interference of calcineurin/mAKAP binding blunts the increase in MEF2 transcriptional activity seen during myoblast differentiation, as well as the expression of endogenous MEF2-target genes. These findings show that MEF-2 can direct early stages of cell differentiation into a cardiomyogenic pathway., Investigators proposed that there have been three extended periods in the evolution of gene regulatory elements. Early vertebrate evolution was characterized by regulatory gains near transcription factors and developmental genes, but this trend was replaced by innovations near extracellular signaling genes, and then innovations near posttranslational protein modifiers.
pipeline_tag: sentence-similarity
library_name: sentence-transformers
metrics: cosine_accuracy@1, cosine_accuracy@3, cosine_accuracy@5, cosine_accuracy@10, cosine_precision@1, cosine_precision@3, cosine_precision@5, cosine_precision@10, cosine_recall@1, cosine_recall@3, cosine_recall@5, cosine_recall@10, cosine_ndcg@10, cosine_mrr@10, cosine_map@100
model-index: name: MedEmbed Biomedical MRL
results: task: type: information-retrieval
name: Information Retrieval
dataset: name: dim 384
type: dim_384
metrics: type: cosine_accuracy@1
value: 0.8330975954738331
name: Cosine Accuracy@1
verified: no, type: cosine_accuracy@3
value: 0.9165487977369166
name: Cosine Accuracy@3
verified: no, type: cosine_accuracy@5
value: 0.9377652050919377
name: Cosine Accuracy@5
verified: no, type: cosine_accuracy@10
value: 0.9504950495049505
name: Cosine Accuracy@10
verified: no, type: cosine_precision@1
value: 0.8330975954738331
name: Cosine Precision@1
verified: no, type: cosine_precision@3
value: 0.3055162659123055
name: Cosine Precision@3
verified: no, type: cosine_precision@5
value: 0.18755304101838755
name: Cosine Precision@5
verified: no, type: cosine_precision@10
value: 0.09504950495049504
name: Cosine Precision@10
verified: no, type: cosine_recall@1
value: 0.8330975954738331
name: Cosine Recall@1
verified: no, type: cosine_recall@3
value: 0.9165487977369166
name: Cosine Recall@3
verified: no, type: cosine_recall@5
value: 0.9377652050919377
name: Cosine Recall@5
verified: no, type: cosine_recall@10
value: 0.9504950495049505
name: Cosine Recall@10
verified: no, type: cosine_ndcg@10
value: 0.8977614955008381
name: Cosine Ndcg@10
verified: no, type: cosine_mrr@10
value: 0.8802883859814552
name: Cosine Mrr@10
verified: no, type: cosine_map@100
value: 0.8816642314418294
name: Cosine Map@100
verified: no, task: type: information-retrieval
name: Information Retrieval
dataset: name: dim 256
type: dim_256
metrics: type: cosine_accuracy@1
value: 0.8288543140028288
name: Cosine Accuracy@1
verified: no, type: cosine_accuracy@3
value: 0.9151343705799151
name: Cosine Accuracy@3
verified: no, type: cosine_accuracy@5
value: 0.9306930693069307
name: Cosine Accuracy@5
verified: no, type: cosine_accuracy@10
value: 0.9448373408769448
name: Cosine Accuracy@10
verified: no, type: cosine_precision@1
value: 0.8288543140028288
name: Cosine Precision@1
verified: no, type: cosine_precision@3
value: 0.30504479019330505
name: Cosine Precision@3
verified: no, type: cosine_precision@5
value: 0.18613861386138608
name: Cosine Precision@5
verified: no, type: cosine_precision@10
value: 0.09448373408769448
name: Cosine Precision@10
verified: no, type: cosine_recall@1
value: 0.8288543140028288
name: Cosine Recall@1
verified: no, type: cosine_recall@3
value: 0.9151343705799151
name: Cosine Recall@3
verified: no, type: cosine_recall@5
value: 0.9306930693069307
name: Cosine Recall@5
verified: no, type: cosine_recall@10
value: 0.9448373408769448
name: Cosine Recall@10
verified: no, type: cosine_ndcg@10
value: 0.892286505977872
name: Cosine Ndcg@10
verified: no, type: cosine_mrr@10
value: 0.8748652926517142
name: Cosine Mrr@10
verified: no, type: cosine_map@100
value: 0.8764556172221414
name: Cosine Map@100
verified: no, task: type: information-retrieval
name: Information Retrieval
dataset: name: dim 128
type: dim_128
metrics: type: cosine_accuracy@1
value: 0.8076379066478077
name: Cosine Accuracy@1
verified: no, type: cosine_accuracy@3
value: 0.9151343705799151
name: Cosine Accuracy@3
verified: no, type: cosine_accuracy@5
value: 0.9264497878359265
name: Cosine Accuracy@5
verified: no, type: cosine_accuracy@10
value: 0.9377652050919377
name: Cosine Accuracy@10
verified: no, type: cosine_precision@1
value: 0.8076379066478077
name: Cosine Precision@1
verified: no, type: cosine_precision@3
value: 0.30504479019330505
name: Cosine Precision@3
verified: no, type: cosine_precision@5
value: 0.18528995756718528
name: Cosine Precision@5
verified: no, type: cosine_precision@10
value: 0.09377652050919376
name: Cosine Precision@10
verified: no, type: cosine_recall@1
value: 0.8076379066478077
name: Cosine Recall@1
verified: no, type: cosine_recall@3
value: 0.9151343705799151
name: Cosine Recall@3
verified: no, type: cosine_recall@5
value: 0.9264497878359265
name: Cosine Recall@5
verified: no, type: cosine_recall@10
value: 0.9377652050919377
name: Cosine Recall@10
verified: no, type: cosine_ndcg@10
value: 0.8820735311180181
name: Cosine Ndcg@10
verified: no, type: cosine_mrr@10
value: 0.863273164051099
name: Cosine Mrr@10
verified: no, type: cosine_map@100
value: 0.8644201365368799
name: Cosine Map@100
verified: no, task: type: information-retrieval
name: Information Retrieval
dataset: name: dim 64
type: dim_64
metrics: type: cosine_accuracy@1
value: 0.7751060820367751
name: Cosine Accuracy@1
verified: no, type: cosine_accuracy@3
value: 0.884016973125884
name: Cosine Accuracy@3
verified: no, type: cosine_accuracy@5
value: 0.9024045261669024
name: Cosine Accuracy@5
verified: no, type: cosine_accuracy@10
value: 0.9165487977369166
name: Cosine Accuracy@10
verified: no, type: cosine_precision@1
value: 0.7751060820367751
name: Cosine Precision@1
verified: no, type: cosine_precision@3
value: 0.29467232437529467
name: Cosine Precision@3
verified: no, type: cosine_precision@5
value: 0.18048090523338045
name: Cosine Precision@5
verified: no, type: cosine_precision@10
value: 0.09165487977369163
name: Cosine Precision@10
verified: no, type: cosine_recall@1
value: 0.7751060820367751
name: Cosine Recall@1
verified: no, type: cosine_recall@3
value: 0.884016973125884
name: Cosine Recall@3
verified: no, type: cosine_recall@5
value: 0.9024045261669024
name: Cosine Recall@5
verified: no, type: cosine_recall@10
value: 0.9165487977369166
name: Cosine Recall@10
verified: no, type: cosine_ndcg@10
value: 0.8513615535952442
name: Cosine Ndcg@10
verified: no, type: cosine_mrr@10
value: 0.8297972654408298
name: Cosine Mrr@10
verified: no, type: cosine_map@100
value: 0.8308414819406362
name: Cosine Map@100
verified: no
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Created: 2025-06-10 15:13:16