Model: yasserrmd/oncology-gemma-300m-emb
Author: yasserrmd
Pipeline: sentence-similarity
Library: sentence-transformers
Tags: sentence-transformers, safetensors, gemma3_text, sentence-similarity, feature-extraction, dense, generated_from_trainer, dataset_size:20000, loss:MultipleNegativesRankingLoss, dataset:miriad/miriad-4.4M, arxiv:1908.10084, arxiv:1705.00652, base_model:google/embeddinggemma-300m, base_model:finetune:google/embeddinggemma-300m, endpoints_compatible, region:us
Base models (finetune): id: google/embeddinggemma-300m
Card metadata: tags: sentence-transformers, sentence-similarity, feature-extraction, dense, generated_from_trainer, dataset_size:20000, loss:MultipleNegativesRankingLoss
base_model: google/embeddinggemma-300m
widget: source_sentence: What are the criteria for evaluating the therapeutic efficacy of tumor treatment?

sentences: Detecting the sentinel node in gastric cancer is challenging due to the complex lymphatic drainage of the stomach. The lymphatic network in the stomach is considerably more complex than that of ectodermal organs like breast and skin, making it difficult to identify the sentinel node accurately. This complexity is attributed to the complex embryological development of the stomach., The criteria for evaluating the therapeutic efficacy of tumor treatment include measuring and calculating the sum of the longest diameter of all target lesions and comparing it with the baseline sum of longest diameters. The objective tumor evaluation criteria include complete remission, partial remission, progressive disease, and stable disease., Low levels of GAS7C mRNA expression have been frequently detected in lung cancer samples, particularly in stage IV and metastatic patients. This suggests an association between low GAS7C expression and cancer progression. Additionally, low GAS7C expression has been correlated with poorer survival in late-stage lung cancer patients from Asian and Caucasian populations. These findings indicate that GAS7C may serve as a prognostic biomarker in lung cancer patients with metastasis. Furthermore, it is possible that GAS7C may act as a metastasis suppressor in other types of cancer., source_sentence: What are the limitations and challenges associated with CTLA-4 blockade as a treatment for advanced melanoma?

sentences: Patients with nonmetastatic RCC following nephrectomy can be risk-stratified using prognostic models such as the UISS scoring system and the Leibovich prognosis score. These models take into account factors such as TNM staging, performance status, tumor size, Fuhrman grade, and tumor necrosis to classify patients into low-, intermediate-, and high-risk groups. The UISS score and the Leibovich score have different criteria for risk stratification, but both provide information on the likelihood of cancer-specific survival or metastasis-free survival. It is important to note that these prognostic models were developed and validated using retrospective patient cohorts and may have limitations. Adjuvant clinical trials in RCC have largely focused on patients with intermediate- to high-risk disease based on these risk stratification methods., FDG accumulation in RCC metastases is an indicator of biological activity and can predict the survival time of patients. Higher FDG accumulation in the primary origin compared to metastases suggests a poor prognosis for RCC patients. Lung metastases tend to show better response to therapies and longer survival compared to non-lung metastases., While CTLA-4 blocking antibodies, such as ipilimumab, have been approved for the treatment of advanced melanoma, their effectiveness is limited to a subset of patients and the impact on survival remains limited. Resistance mechanisms to CTLA-4 blockade need to be identified. Additionally, the presence of an immunosuppressive microenvironment and the inhibitory role of IDO in antitumor therapies targeting immune checkpoints pose challenges to the efficacy of CTLA-4 blockade., source_sentence: What are some alternative therapeutic strategies being evaluated for cancer treatment?

sentences: The combination of Chinese herbal therapies, such as PAM+V (tonifying blood yin, tonifying Spleen yin/qi, harmonizing Liver qi, and tonifying Kidney yang), with conventional therapies has been shown to improve survival outcomes in advanced non-small-cell lung cancer patients. In a retrospective survival analysis, patients treated with long-term PAM+V therapy combined with standard therapy achieved significantly better survival in stages IIIA, IIIB, and IV disease. The survival advantage was even stronger when comparing long-term users of PAM+V with external controls. These results suggest that prospective trials using PAM+V and vitamin therapy, in a whole-systems approach combined with conventional therapies, are justified for advanced non-small-cell lung cancer patients., Prostate cancer management faces challenges such as overdiagnosis, overtreatment, and the need for accurate diagnosis, treatment selection, and individualized approaches. Precision medicine in prostate cancer aims to address these challenges by providing more accurate diagnostic tests, guiding the selection of necessary curative treatments, offering appropriate adjuvant therapy after radical prostatectomy, and identifying good candidates for secondary hormonal manipulation in castration-resistant prostate cancer., One alternative therapeutic strategy being evaluated for cancer treatment is hyperthermia. Hyperthermia involves exposing biological tissues to temperatures higher than normal to selectively destroy abnormal cells. This approach can inhibit tumor cell proliferation by destroying cancer cells or making them more sensitive to the effects of conventional antitumor therapies. Various heating sources, such as radiofrequency, microwaves, and ultrasound waves, have been used to produce moderate heating in a specific target region. However, the use of these heating sources is limited due to the damage they cause to surrounding healthy tissues., source_sentence: What are the potential implications of CD200 expression in Merkel cell carcinoma (MCC)?

sentences: The prognosis for breast carcinoid is similar to that for other primary breast carcinomas and correlates with stage, size, and lymph node status. Localized spread in primary breast carcinoid has been reported to have favorable outcomes. Roughly 18% of all mammary carcinoid cases have involved nodal or distant metastases, which occurred only after the tumor had achieved a size of 2.5 cm or greater with 10 or more mitoses per high-power field. Metastatic breast carcinoid appears to carry with it a prognosis similar to that of carcinoid metastatic to other locations. Treatment for primary mammary carcinoid is also similar to that for other primary breast carcinomas and includes lumpectomy for small lesions or modified radical mastectomy for greater disease spread. Adjuvant radiation therapy and chemotherapeutic agents such as cisplatin and etoposide may also be used., CD200 expression was observed in a high percentage (84%) of MCC cases. However, the expression of CD200 does not add much to the immunohistochemical diagnosis of MCC, as MCC already has a well-defined immunoprofile. Nonetheless, the expression of CD200 in MCC warrants further study to determine if it plays a role in the biology of the disease, if it represents a potential therapeutic target, or if loss of CD200 affects prognosis., The risk factors associated with delayed recurrence after liver resection for HCC include the presence of cirrhosis (F4), hepatitis activity, multinodularity, vascular invasion, and moderate or poorly differentiated HCC. These factors increase the likelihood of recurrence occurring beyond 2 years after surgery., source_sentence: What are the current standard treatments for glioblastoma multiforme (GBM) and why is recurrence almost unavoidable?

sentences: The main mechanisms responsible for oncogene-mediated drug resistance in ovarian cancer include deregulation of apoptosis, altered phosphorylation (intracellular signaling), and metabolic pathways. Activation of the PI3K/AKT cell survival pathway, as well as deregulation of growth factor receptors mediated by NF-kB and STAT3, plays a pivotal role in drug resistance. Additionally, alterations in DNA damage and repair mechanisms, impaired apoptotic machinery, and epithelial-to-mesenchymal transition (EMT) have been implicated in drug resistance. Wnt signaling, particularly the β-catenin-independent pathway via Wnt5a/ROR1/ROR2, is also involved in EMT and chemoresistance. Targeting these pathways may offer potential means to overcome drug resistance in ovarian cancer., The overexpression of GALNT2 in oral squamous cell carcinoma (OSCC) cells can promote their invasive potential. GALNT2 modifies the O-glycosylation of proteins and increases the activity of epidermal growth factor receptor (EGFR), which plays a crucial role in the invasive behavior of OSCC cells. This suggests that GALNT2 may be involved in the occurrence and development of OSCC., The current standard treatment for GBM includes surgery, radiotherapy, and chemotherapy. However, complete surgical resection is not possible, and GBM is resistant to chemotherapy, including the commonly used drug temozolomide (TMZ). This resistance and the inability to completely remove the tumor during surgery contribute to the high recurrence rate of GBM.
pipeline_tag: sentence-similarity
library_name: sentence-transformers
datasets: miriad/miriad-4.4M
Likes: 2 | All-time downloads: 47
Created: 2025-09-14 13:25:38