Model: gutsartificial/bge-small-en-v1.5-2025-01-01_21-55-17
Author: gutsartificial
Pipeline: sentence-similarity
Library: sentence-transformers
Tags: sentence-transformers, safetensors, bert, sentence-similarity, feature-extraction, generated_from_trainer, dataset_size:650596, loss:CachedGISTEmbedLoss, arxiv:1908.10084, base_model:BAAI/bge-small-en-v1.5, base_model:finetune:BAAI/bge-small-en-v1.5, model-index, text-embeddings-inference, endpoints_compatible, region:us
Base models (finetune): id: BAAI/bge-small-en-v1.5
Card metadata: tags: sentence-transformers, sentence-similarity, feature-extraction, generated_from_trainer, dataset_size:650596, loss:CachedGISTEmbedLoss
base_model: BAAI/bge-small-en-v1.5
widget: source_sentence: Represent this sentence for searching relevant passages: How does a high-carbohydrate diet affect inflammation markers and cytokine levels in goats?
sentences: During carcinogenesis, the tested lactobacilli mix, especially the anti-inflammatory M2-programming VD23 strain, ameliorates the inflammatory conditions (in the early stages) and/or the pro-inflammatory M1-programming MS3 strain can boost an anti-tumour immune response with the down-stream effect of eliminating dysplastic and cancerous cells. With respect to long-term study of CRC, where cancer arises from chronic inflammation and leads to an immunosuppressive state with tumour presence, a mixture of probiotic bacteria with both anti- and pro-inflammatory (M2- and M1-programming) features was used, and this may represent a realistic approach to harnessing probiotic strains in the modulation of CRC. 
While body weight gain over the experimental period did not differ, there was a significant difference in daily food intake between all experimental groups. Despite the increased food intake of the DMH group compared to the DMH+P group, the rats’ ability to convert food into body mass (expressed by FER) was not significantly affected. The probiotic-fed group was shown to have the highest FER, therefore it can be suggested that probiotic treatment can improve absorption and digestion of food., LBP is highly sensitive to LPS, and its plasma levels drastically raise up to 200% in goats fed HC diets and hence considered as reliable biomarker of systemic inflammation (Chang, Zhang, Xu, Jin, Seyfert, et al., ; Dong et al., ). The APPs production is stimulated by HC diet‐derived LPS in liver through activation of toll‐like receptor‐4 (TLR‐4)‐mediated nuclear factor kappa B (NF‐kB)‐tumor necrosis factor‐α (TNF‐α) signaling pathway in immune cells (Ciesielska et al., ; Kany et al., ). It has been shown that HC diets induce NF‐κB expression through LPS and thereby modulate the expressions of related cytokines, such as TNF‐α, interleukin‐1β (IL‐1β), IL‐6, and IL‐10, and consequently altered the AAPs production in livers of ruminants (Chang, Zhang, Xu, Jin, Guo, et al., ; Dong et al., ; Guo et al., )., After 48 h transfection, cells were used in the electrophysiology assays in the automated whole-cell patch clamp system QPatch 16X (Sophion Bioscience). 
The extracellular solution comprised 140 NaCl, 5 KCl, 10 CaCl 2, 2 MgCl 2, 10 glucose and 10 HEPES at pH 7.4 and 320 mOsm. The intracellular solution comprised (in mM) 150 KCl, 1 MgCl 2, 4 NaCl, 0.5 EGTA and 10 HEPES at pH 7.4 and 320 mOsm. Cells were maintained at a holding potential –90 mV and K + currents elicited by +20 mV pulse for 500 ms followed by –40 mV pulse for additional 500 ms., source_sentence: Represent this sentence for searching relevant passages: What software is used for carrying out statistics in experiments?
sentences: Regarding to the association of dietary intake and CRC, the cases with TT genotype of FTO rs9939609 polymorphism had lower intake of copper (1.49 ± 0.64 vs. 1.76 ± 0.71 g/d, p = 0.02), selenium (56.15 ± 22.97 vs. 67.26 ± 15.11 g/d, p < 0.01), β-carotene (2189.73 ± 474.3 vs. 2461.75 ± 772.57 g/d, p = 0.01), vitamin E (10.58 ± 4.14 vs. 13.99 ± 6.4 g/d, p < 0.01), tocopherol (8.46 ± 2.91 vs. 9.79 ± 4.53 g/d, p = 0.032), vitamin B 1 (1.91 ± 0.87 vs. 2.3 ± 0.82 g/d, p = 0.01), folate (528 ± 0.61 vs. 574.39 ± 95.19 g/d, p = 0.01), biotin (26.76 ± 3.75 vs. 29.33 ± 6.61 g/d, p < 0.01) and higher intake of calorie (2500.48 ± 165.87 vs. 2594.64 ± 333.4 g/d, p = 0.021), fat (86.57 ± 10.38 vs. 93.25, ± 17.13 p < 0.01), fluoride (13967.59 ± 5662.25 vs. 11112.32 ± 3051.44 g/d, p < 0.01), vitamin A (819.7 ± 251.03 vs. 712.76 ± 113.86 g/d, p = 0.01), and vitamin K (157.9 ± 30.4 vs. 146.74 ± 21.64 g/d, p = 0.03)., All concentration estimates are standardized by faecal weight and depicted as concentration per gram of faeces. 
All quantitative PCR reactions were conducted in 12.5 μl volumes using the SYBR green Master Mix (Roche). Quantitative PCR experiments were conducted on a Lightcycler LC480 instrument (Roche). Template quantity and quality was assessed using a Nanodrop spectrophotometer. Abundance estimates are standardized to the concentration of input DNA per reaction and are represented as copies per nanogram of faecal DNA. Template extraction for quantification of faecal bacteria loads: DNA was extracted from fresh faecal pellets using the PowerFecal DNA Isolation Kit (Mo Bio) following kit instructions. Bacterial loads were quantified using previously validated bacterial group-specific 16S primers. 
Statistics were carried out using JMP9.0 (SAS), Prism 6.0 (Graphpad) and R software. permutational analysis of variance was used for hypothesis testing of significance between groups shown in PcoA plots., Postmenopausal diabetic women are at higher risk to develop cardiovascular diseases (CVD) compared with nondiabetic women. Alterations in cardiac cellular metabolism caused by changes in sirtuins are one of the main causes of CVD in postmenopausal diabetic women. Several studies have demonstrated the beneficial actions of the G protein-coupled estrogen receptor (GPER) in postmenopausal diabetic CVD. However, the molecular mechanisms by which GPER has a cardioprotective effect are still not well understood. In this study, we used an ovariectomized (OVX) type-two diabetic (T2D) rat model induced by high-fat diet/streptozotocin to investigate the effect of G-1 (GPER-agonist) on sirtuins, and their downstream pathways involved in regulation of cardiac metabolism and function. Animals were divided into five groups: Sham-Control, T2D, OVX+T2D, OVX+T2D+Vehicle, and OVX+T2D+G-1. G-1 was administrated for six weeks., source_sentence: Represent this sentence for searching relevant passages: Why might a VRAM flap be a more optimal choice for patients with an end colostomy?
sentences: As they will have an end colostomy, which will be their only stoma, then a VRAM flap is a more optimal choice given the bulk and ability to fill dead space with this flap. Very few patients had infection or dehiscence in the postoperative period. Donor-site hernia is a concern with the VRAM flap, particularly given an open very large laparotomy incision which may often be a reoperation. This occurred in 9.5% of the VRAM patients, and the same number of patients required a delayed reoperation which was on an elective basis. VRAM, as well as ALT flaps can be used to restore the anatomy of the pelvic floor preventing herniation into the resection space. The ‘marine patch’ principle applies where the flap lies on the side of hydrostatic pressure, so even if there is perineal skin breakdown then the muscle flap component still provides cover for the abdominal contents. Compared with Baird and colleagues, we reserved VRAM flaps for this reason to APR and ELAPE patients. VRAM is not used in exenteration in our centre due to two stomas being formed during urinary diversion., In the present study, we used a recently developed novel steatohepatitis-inducing HFD, STHD-01 , to induce NASH. This novel HFD contains a high amount of cholesterol, which is not contained in conventionally used HFDs, and induces the development of severe NASH, while conventionally-used HFDs only induce mild to moderate NASH in a shorter period of time. Another specific feature of STHD-01 is that STHD-01 does not affect fasting blood glucose levels (Additional file ). While certain type of diet, such as methionine- and choline-deficient diet (MCD), can also cause an advanced NASH , this diet decreases fasting blood glucose levels in experimental animals. Since non-overweight human patients with NAFLD do not show decreased fasting blood glucose levels compared to non-fatty liver disease patients , STHD-01 is a better approximation of the clinical condition. One obvious difference in the phenotypes between the mice fed with the STHD-01 and the conventional HFD is body weight gain., Only 107 (13.8%) were satisfied, and 667 (84%) were dissatisfied. Regarding the reasons for dissatisfaction, 355 (45.9%) subjects reported that they did not get enough explanation, 292 (37.7%) reported that they did not get enough investigations, and only 20 (2.6%) thought that they did not get enough medications, as shown in Figure. 
Of 863 subjects with heartburn, QoL was not affected at all in 295 (34%), a little in 210 (24%), somewhat in 125 (15%), a lot in 208 (24%), and a great deal in 25 (3%) subjects. Considering a lot and a great deal as the significant impairment of QoL, 233 (27%) of the subjects had impaired QoL due to heartburn. 
This cross‐sectional study conducted among the adult population in a rural community of Bangladesh found that about 26% of the population had heartburn, 11% chest pain, 8% globus, and 4% had dysphagia. One‐third of the study population had at least one esophageal symptom., source_sentence: Represent this sentence for searching relevant passages: What percentage of the UAE's population resides in Sharjah?
sentences: Currently, there is a scarcity of data about the practice and impact of OTC medication usage among pregnant women in UAE. Accordingly, this study was planned and designed with the aim of exploring the awareness and assessing the usage of OTC medications among pregnant women in Sharjah, UAE. 
The study was conducted after the approval of the University of Sharjah Ethics Committee, Sharjah, UAE (reference number: REC-16-10-03-01-S). 
A cross-sectional survey was conducted to assess the level of awareness and knowledge of pregnant women concerning OTC drugs. The study took place in the Emirate of Sharjah, UAE, over a period of three months (October to December 2016). 
Sharjah is the third largest of the seven emirates that make up the UAE and is the only one to have land on both the Arabian Gulf Coast and the Gulf of Oman. Residents of Sharjah represent around 19% of the UAE's population (4.76 million) (Ministry of Economy, 2008). Within the UAE, it has been reported that the crude birth rate or birth rate per 1,000 population was 15.54 during the year of 2014., However, following a more painful surgery, children in the VR group needed rescue analgesia significantly less often ( p = 0.002). In 2021, a total of 50 children aged 6–12-years old were included in a RCT evaluating the effect of VR compared to standard screen TV in reducing anxiety for buccal infiltration anesthesia. No significant difference was observed between the groups, but female and younger patients showed higher pain scores during the dentistry procedure. Two recent meta-analyses that included a maximum of 17 studies evaluating the effect of VR on pain and anxiety in a pediatric population concluded that VR is an effective distraction intervention to reduce pain and anxiety in children. 
Finally, other medical fields have also explored the role of VR in anxiety reduction. In gastroenterology, VR has been used prior to endoscopic procedures to reduce anxiety and has shown promising results, reducing anxiety significantly in patients with a higher anxiety level (STAI-score ≥ 45) at baseline ( p = 0.007)., Picrosirius Red staining also demonstrated an increase in total collagen deposition in the right carotid artery due to TAC-induced vascular changes. Alamandine treatment effectively prevented the increase in reactive oxygen species production and depletion of nitric oxide levels, which were induced by TAC. Finally, alamandine treatment was also shown to prevent the increased expression of nuclear factor erythroid 2-related factor 2 and 3-nitrotyrosine that were induced by TAC. Our results suggest that alamandine can effectively attenuate pathophysiological stress in the right carotid artery of animals subjected to TAC., source_sentence: Represent this sentence for searching relevant passages: What are some effects of maternal iron deficiency on adult male offspring development?
sentences: Parents report encouraging their children to engage in “healthy” lifestyle choices, including making alterations to diet, physical activity (PA), and sleep behavior, which may (1) help parents feel more in control over the impact of the condition, and (2) allow them gain a more positive outlook on the future. Unfortunately, even in the adult MS literature, there is insufficient evidence to make clinical recommendations regarding lifestyle modifications. Improving the body of literature on modifiable lifestyle factors in pediatric MS with the goal of creating guidelines that will help POMS patients and their parents deal with these difficult decisions is needed. 
Our objective in this manuscript is to summarize and identify gaps in current research on modifiable lifestyle factors and pediatric MS. Two questions guided this review: (1) Which modifiable lifestyle factors have been investigated in the context of POMS? And (2) which factors have been shown to play a role in the risk of POMS, disease course, or quality of life? 
We used the Arksey and O’Malley framework to guide this review., The mRNA expression levels of the OMH-treated HT-115 cells indicated that the cytosolic CYP1A levels were two-fold upregulated. In addition, OMH triggers the mitochondrial release of cytochrome c, which stabilize the fundamental oxido-reduction cycle in mitochondria. The activation of CYP1A effectively controls the pro-oxidants and oxidative stress in colon cancer cells further, suppressing the proinflammatory cytokines IL-1β and TNF-α, which favors the deactivation of malignant cell apoptosis inhibitor NF-kB in colon cancer cells. The observed antioxidant capacity neutralizes proinflammatory TNF-α/IL-1β, inhibiting protumorigenic COX-2/PGE-2 and stimulating the apoptosis mechanism via the inhibition of NF-kB, an apoptosis inhibitor. OMH effectively maintains the balance between Bcl-2 and Bax (Bcl-2-associated X pro-apoptotic gene) and inclines the cells to apoptotic stimulation., We found three differentially abundant taxonomic classes in the IDD group using an LDA effect size calculation with an LDA score higher than 4.0. The results showed that the Bacteroidaceae genus Bacteroides and Lachnospiraceae genus Marvinbryantia were significantly increased in rats in the IDD group compared to rats in the other groups (C). 
In this study, we showed that maternal iron deficiency may program and alter adult male offspring development with regard to spatial learning and memory, dorsal hippocampus BDNF expression, gut microbiota, and SCFA concentrations. Our results showed that the adult male offspring of rats that were fed a low-iron diet before pregnancy and throughout the lactation period had (1) spatial deficits via a Morris water maze evaluation; (2) decreased dorsal hippocampal BDNF mRNA and protein concentrations accompanied by a low TrkB abundance; (3) a decreased plasma acetate concentration without changes in butyrate and propionate concentrations; (4) enrichment of the Bacteroidaceae genus Bacteroides and Lachnospiraceae genus Marvinbryantia.
pipeline_tag: sentence-similarity
library_name: sentence-transformers
metrics: cosine_accuracy@1, cosine_accuracy@3, cosine_accuracy@5, cosine_accuracy@10, cosine_precision@1, cosine_precision@3, cosine_precision@5, cosine_precision@10, cosine_recall@1, cosine_recall@3, cosine_recall@5, cosine_recall@10, cosine_ndcg@10, cosine_mrr@10, cosine_map@100
model-index: name: SentenceTransformer based on BAAI/bge-small-en-v1.5
results: task: type: information-retrieval
name: Information Retrieval
dataset: name: Unknown
type: unknown
metrics: type: cosine_accuracy@1
value: 0.5853673532124193
name: Cosine Accuracy@1
verified: no, type: cosine_accuracy@3
value: 0.7196126652320934
name: Cosine Accuracy@3
verified: no, type: cosine_accuracy@5
value: 0.7634798647402398
name: Cosine Accuracy@5
verified: no, type: cosine_accuracy@10
value: 0.8083922533046418
name: Cosine Accuracy@10
verified: no, type: cosine_precision@1
value: 0.5853673532124193
name: Cosine Precision@1
verified: no, type: cosine_precision@3
value: 0.2398708884106978
name: Cosine Precision@3
verified: no, type: cosine_precision@5
value: 0.15269597294804796
name: Cosine Precision@5
verified: no, type: cosine_precision@10
value: 0.0808392253304642
name: Cosine Precision@10
verified: no, type: cosine_recall@1
value: 0.5853673532124193
name: Cosine Recall@1
verified: no, type: cosine_recall@3
value: 0.7196126652320934
name: Cosine Recall@3
verified: no, type: cosine_recall@5
value: 0.7634798647402398
name: Cosine Recall@5
verified: no, type: cosine_recall@10
value: 0.8083922533046418
name: Cosine Recall@10
verified: no, type: cosine_ndcg@10
value: 0.6971481810101028
name: Cosine Ndcg@10
verified: no, type: cosine_mrr@10
value: 0.6614873816111168
name: Cosine Mrr@10
verified: no, type: cosine_map@100
value: 0.6662955818767544
name: Cosine Map@100
verified: no
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Created: 2025-01-04 21:47:17