Model: FareedKhan/intfloat_multilingual-e5-large-instruct_FareedKhan_prime_synthetic_data_2k_2_4
Author: FareedKhan
Pipeline: sentence-similarity
Library: sentence-transformers
Tags: sentence-transformers, safetensors, xlm-roberta, sentence-similarity, feature-extraction, generated_from_trainer, dataset_size:1814, loss:MatryoshkaLoss, loss:MultipleNegativesRankingLoss, arxiv:1908.10084, arxiv:2205.13147, arxiv:1705.00652, base_model:intfloat/multilingual-e5-large-instruct, base_model:finetune:intfloat/multilingual-e5-large-instruct, model-index, text-embeddings-inference, endpoints_compatible, region:us
Base models (finetune): id: intfloat/multilingual-e5-large-instruct
Card metadata: base_model: intfloat/multilingual-e5-large-instruct
library_name: sentence-transformers
metrics: cosine_accuracy@1, cosine_accuracy@3, cosine_accuracy@5, cosine_accuracy@10, cosine_precision@1, cosine_precision@3, cosine_precision@5, cosine_precision@10, cosine_recall@1, cosine_recall@3, cosine_recall@5, cosine_recall@10, cosine_ndcg@10, cosine_mrr@10, cosine_map@100
pipeline_tag: sentence-similarity
tags: sentence-transformers, sentence-similarity, feature-extraction, generated_from_trainer, dataset_size:1814, loss:MatryoshkaLoss, loss:MultipleNegativesRankingLoss
widget: source_sentence: 

The gene in question appears to be involved in multiple cellular processes, many of which are central to neuronal function and health, especially in the context of neurodegenerative diseases. Here's a brief overview of its functions and context:

### Key Functions:
1. **Transcription Regulation**: Involved in RNA polymerase II transcription and regulation of gene expression.
2. **Protein Processing**: Positive regulation of proteasomal ubiquitin-dependent protein catabolic process, indicating it might play a role in the degradation and recycling of proteins.
3. **Cellular Stress Response**: Regulation of positive transcription by p53 (a known DNA damage response gene), positive regulation of I-kappaB kinase/NF-kappaB signaling (involved in inflammatory response), and negative regulation of cell death under oxidative stress.
4. **Cellular Repair and Maintenance**: Autophagy of mitochondria (self-eating of organelles to clear damaged components), regulated the negative regulation of intrinsic apoptotic signaling pathways, facilitating cell survival rather than death.
5. **Neurotransmitter and Ion Handling**: Involvement in dopamine secretion, response to manganese ion, and within synaptic transmission processes.
6. **Metabolic Activities**: Influences glucose metabolism by regulation of glucokinase activity.

### Context Specific:
- **Manganese Exposure**: This gene's role in transcriptional regulation is particularly implicated in the context of manganese exposure. Manganese can be neurotoxic, particularly affecting the nervous system. Its regulation might help in the cellular response to manganese toxicity, including signaling pathways that
sentences: Identify genes or proteins that interact with CLDN11 and are also implicated in the same medical condition., Search for ailments that have no drugs indicated for treatment and have a connection to Dermatographic urticaria., Is there an interaction between the parkin RBR E3 ubiquitin protein ligase and the DNA-damage-inducible transcript 4 (DDIT4), and if so, what biological effects or phenotypes have been associated with this interaction?, source_sentence: 
Risdiplam, an orally bioavailable mRNA splicing modifier, serves as a treatment for spinal muscular atrophy (SMA), increasing systemic SMN protein
sentences: Which medication shares a gene or protein carrier with Clobetasol propionate and also elevates SMN protein levels to aid in the management of Spinal Muscular Atrophy?, Which gene or protein is known to engage with SIRT1 and also modulates cholesterol levels, and has been linked to effects or phenotypes that resemble those associated with SIRT1?, What is the name of the heart disease associated with the abnormal tricuspid subvalvular apparatus that leads to restricted leaflet motion and regurgitation in the tricuspid valve?, source_sentence: 
The list you provided includes a wide variety of substances that are categorized based on their primary function or use. Here's a breakdown based on their classifications:

### Medications and Drugs
- **Anabolics (e.g., Methandrostenolone, Nandrolone)**: Steroids used for increasing muscle mass and strength.
- **Antidepressants (e.g., Sertraline, Flunarizine)**: Drugs used to treat depression and anxiety disorders.
- **Anticoagulants (e.g., Warfarin, Apixaban)**: Medications used to prevent blood clots.
- **Antivirals (e.g., Adefovir, Etoricoxib)**: Antiviral drugs used to treat viral infections such as hepatitis.
- **Anticancer Drugs (e.g., Atemzan, Sorafenib)**: Used in chemotherapy and targeted therapy for cancer treatment.
- **Antipsychotics (e.g., Haloperidol, Sertaconazole)**: Medications used in the treatment of psychosis and other mental disorders.
- **Anesthetic Agents (e.g., Ketamine, Etomidate)**: Used for inducing and maintaining general anesthesia
sentences: What disease acts as a common subtype to both prostate carcinoma and prostatic urethra urothelial carcinoma, indicating an overlap in their clinical categorizations?, Could you tell me about the medications available that specifically target mantle cell lymphoma, particularly those acting on the BTK pathway, to effectively address the underlying disease mechanism?, Which medication shares a gene or protein transporter with Zileuton and serves as a chain-terminating agent by integrating into the viral DNA replication process?, source_sentence: 
Xanthogranulomatous pyelonephritis is a disease characterized by chronic, destructive infections of the kidney, marked by the infiltration of lipid-laden macrophages. This condition is often linked to obstruction due to infected renal stones, commonly caused by bacteria such as Proteus or Escherichia coli. The UMLS description highlights that this disease results in diffuse renal destruction, leading to a grossly enlarged and nonfunctional kidney. It is closely related to pyelonephritis, and its symptoms include nephrolithiasis and kidney stones. The involvement of macrophage infiltration and tissue destruction, along with its links to nephrolithiasis and urinary obstruction, makes xanthogranulomatous pyelonephritis a disease with significant similarities to pyelonephritis.
sentences: Identify genes or proteins that interact with IL1R1 and are concurrently linked to identical phenotypes or biological effects., What renal disease might involve macrophage infiltration and tissue destruction, with links to nephrolithiasis and urinary obstruction, similar to pyelonephritis?, Please find genes or proteins that interact with AGO2 and bind to the AU-rich elements in mRNA 3'-UTRs., source_sentence: 

The gene in question appears to have a multifaceted role and involvement in various biological processes, diseases, and anatomical structures, with implications for both physiology and pathology. Here is a summary of its characteristics:

### Function and Interactions
- **Name**: mTORC1, a component of the mammalian target of rapamycin complex 1.
- **Role**: Involved in regulation of membrane potential
sentences: Which solid-state medications specifically engage with the METAP2 gene/protein through direct interaction?, Which pharmacological agents designed to bind genes or proteins associated with RNA polymerase I that have the potential to induce regression of lung tumors?, Identify genes or proteins that interact with KCNMB1 and share an associated phenotype or effect.
model-index: name: SentenceTransformer based on intfloat/multilingual-e5-large-instruct
results: task: type: information-retrieval
name: Information Retrieval
dataset: name: dim 768
type: dim_768
metrics: type: cosine_accuracy@1
value: 0.400990099009901
name: Cosine Accuracy@1
verified: no, type: cosine_accuracy@3
value: 0.4603960396039604
name: Cosine Accuracy@3
verified: no, type: cosine_accuracy@5
value: 0.4900990099009901
name: Cosine Accuracy@5
verified: no, type: cosine_accuracy@10
value: 0.5445544554455446
name: Cosine Accuracy@10
verified: no, type: cosine_precision@1
value: 0.400990099009901
name: Cosine Precision@1
verified: no, type: cosine_precision@3
value: 0.15346534653465344
name: Cosine Precision@3
verified: no, type: cosine_precision@5
value: 0.09801980198019801
name: Cosine Precision@5
verified: no, type: cosine_precision@10
value: 0.05445544554455445
name: Cosine Precision@10
verified: no, type: cosine_recall@1
value: 0.400990099009901
name: Cosine Recall@1
verified: no, type: cosine_recall@3
value: 0.4603960396039604
name: Cosine Recall@3
verified: no, type: cosine_recall@5
value: 0.4900990099009901
name: Cosine Recall@5
verified: no, type: cosine_recall@10
value: 0.5445544554455446
name: Cosine Recall@10
verified: no, type: cosine_ndcg@10
value: 0.46500004508597764
name: Cosine Ndcg@10
verified: no, type: cosine_mrr@10
value: 0.4406471004243281
name: Cosine Mrr@10
verified: no, type: cosine_map@100
value: 0.44882168670509337
name: Cosine Map@100
verified: no
Likes: 0 | All-time downloads: 168
Created: 2024-09-30 10:16:44