PathoHR: Breast Cancer Survival Prediction on High-Resolution
  Pathological Images
Authors: name: Yang Luo; name: Shiru Wang; name: Jun Liu; name: Jiaxuan Xiao; name: Rundong Xue; name: Zeyu Zhang; name: Hao Zhang; name: Yu Lu; name: Yang Zhao; name: Yutong Xie
Published: 2025-03-23 07:37:24

Abstract: Breast cancer survival prediction in computational pathology presents a
remarkable challenge due to tumor heterogeneity. For instance, different
regions of the same tumor in the pathology image can show distinct
morphological and molecular characteristics. This makes it difficult to extract
representative features from whole slide images (WSIs) that truly reflect the
tumor's aggressive potential and likely survival outcomes. In this paper, we
present PathoHR, a novel pipeline for accurate breast cancer survival
prediction that enhances any size of pathological images to enable more
effective feature learning. Our approach entails (1) the incorporation of a
plug-and-play high-resolution Vision Transformer (ViT) to enhance patch-wise
WSI representation, enabling more detailed and comprehensive feature
extraction, (2) the systematic evaluation of multiple advanced similarity
metrics for comparing WSI-extracted features, optimizing the representation
learning process to better capture tumor characteristics, (3) the demonstration
that smaller image patches enhanced follow the proposed pipeline can achieve
equivalent or superior prediction accuracy compared to raw larger patches,
while significantly reducing computational overhead. Experimental findings
valid that PathoHR provides the potential way of integrating enhanced image
resolution with optimized feature learning to advance computational pathology,
offering a promising direction for more accurate and efficient breast cancer
survival prediction. Code will be available at
https://github.com/AIGeeksGroup/PathoHR.