Generalist Foundation Models Are Not Clinical Enough for Hospital Operations
Authors: name: Lavender Y. Jiang; name: Angelica Chen; name: Xu Han; name: Xujin Chris Liu; name: Radhika Dua; name: Kevin Eaton; name: Frederick Wolff; name: Robert Steele; name: Jeff Zhang; name: Anton Alyakin; name: Qingkai Pan; name: Yanbing Chen; name: Karl L. Sangwon; name: Daniel A. Alber; name: Jaden Stryker; name: Jin Vivian Lee; name: Yindalon Aphinyanaphongs; name: Kyunghyun Cho; name: Eric Karl Oermann
Published: 2025-11-17 18:52:22

Abstract: Hospitals and healthcare systems rely on operational decisions that determine patient flow, cost, and quality of care. Despite strong performance on medical knowledge and conversational benchmarks, foundation models trained on general text may lack the specialized knowledge required for these operational decisions. We introduce Lang1, a family of models (100M-7B parameters) pretrained on a specialized corpus blending 80B clinical tokens from NYU Langone Health's EHRs and 627B tokens from the internet. To rigorously evaluate Lang1 in real-world settings, we developed the REalistic Medical Evaluation (ReMedE), a benchmark derived from 668,331 EHR notes that evaluates five critical tasks: 30-day readmission prediction, 30-day mortality prediction, length of stay, comorbidity coding, and predicting insurance claims denial. In zero-shot settings, both general-purpose and specialized models underperform on four of five tasks (36.6%-71.7% AUROC), with mortality prediction being an exception. After finetuning, Lang1-1B outperforms finetuned generalist models up to 70x larger and zero-shot models up to 671x larger, improving AUROC by 3.64%-6.75% and 1.66%-23.66% respectively. We also observed cross-task scaling with joint finetuning on multiple tasks leading to improvement on other tasks. Lang1-1B effectively transfers to out-of-distribution settings, including other clinical tasks and an external health system. Our findings suggest that predictive capabilities for hospital operations require explicit supervised finetuning, and that this finetuning process is made more efficient by in-domain pretraining on EHR. Our findings support the emerging view that specialized LLMs can compete with generalist models in specialized tasks, and show that effective healthcare systems AI requires the combination of in-domain pretraining, supervised finetuning, and real-world evaluation beyond proxy benchmarks.