{ "Contributors": [ "Pegah Alipoormolabashi" ], "Source": [ "PICO" ], "URL": [ "https://github.com/Markus-Zlabinger/pico-annotation" ], "Categories": [ "Information Extraction" ], "Reasoning": [], "Definition": [ "In medical studies, the efficacy of medical treatments (called interventions) is evaluated within a group of study participants. You will be given a sentence of a study report in which your task is to list the phrases that describe the intervention(s) of the study. You should list the phrase in the same order that they appear in the text, separated by commas. If no information about the interventions is mentioned, just answer with \"not found\". Interventions are: a specific drug, surgery, talking therapy, a lifestyle modification, control or placebo treatment. Do not include details, dosages, frequency and duration, intervention mentions that are not in an informative span of text." ], "Input_language": [ "English" ], "Output_language": [ "English" ], "Instruction_language": [ "English" ], "Domains": [ "Academical Papers" ], "Positive Examples": [ { "input": "The patients received either azithromycin (600 mg/d for 3 days during week 1, then 600 mg/wk during weeks 2-12; n = 3879) or placebo (n = 3868)", "output": "azithromycin, placebo", "explanation": "The word azithromycin refers to a drug, and placebo refers to a control test. Note that no extra information is given in the output." }, { "input": "We report findings of a pilot RCT for a parent training intervention with a focus on the development of joint attention skills and joint action routines. ", "output": "parent training intervention", "explanation": "The words parent, training, and intervention refer to some kind of talking therapy." }, { "input": "Seventy-two people residing in National Health Service (U.K.) care facilities who had clinically significant agitation in the context of severe dementia were randomly assigned to aromatherapy with Melissa essential oil (N = 36) or placebo (sunflower oil) (N = 36). ", "output": "aromatherapy with melissa essential oil, placebo, sunflower oil", "explanation": "Both the therapy and the control treatment are mentioned as spans of text here." } ], "Negative Examples": [ { "input": "Treatment consisted of nitrendipine (10-40 mg/d), with the possible addition of enalapril maleate (5-20 mg/d), hydrochlorothiazide (12.5-25 mg/d), or both add-on drugs.", "output": "nitrendipine (10-40 mg/d, ), enalapril, maleate (5-20, mg/d), hydrochlorothiazide (12.5-25, mg/d), both add-on drugs", "explanation": "The drugs are correctly mentioned as intervention, but their dosage shouldn't be given as answer." }, { "input": "Zinc lozenges, 10 mg, orally dissolved, 5 times a day (in grades 1-6) or 6 times a day (in grades 7-12). ", "output": "Zinc lozenges, orally dissolved", "explanation": "Information about the method the intervention is given to patients, in this case \"orally dissolved\" should not be given as answer." }, { "input": "Antihypertensive therapy was started immediately after randomization in the active treatment group, but only after termination of the double-blind trial in the control patients.", "output": "Antihypertensive therapy, double-blind trial", "explanation": "The words double-blind and trial are not related to intervention." } ], "Instances": [ { "id": "task180-1de3d8205ca94199af138be4aad7a9e5", "input": "Outcome results applied to life expectancy tables were used to estimate QALYs .", "output": [ "not found" ] }, { "id": "task180-a3f11f36d64b46bf8146415682981292", "input": "These types of gastric myoelectrical activity and dysrhythmia can be measured by electrogastrography using cutaneous electrodes .", "output": [ "not found" ] }, { "id": "task180-8613d2ccc8eb450f840bddef82f588e0", "input": "Serum and urine biochemical parameters related to calcium status and bone metabolism remained unaltered .", "output": [ "not found" ] }, { "id": "task180-7854d152f9c248f1983b2f522a5d60c5", "input": "After 24 months , women who took medications without exercising had significant improvements in BMD at the total hip ( +1.81 % ) and spine ( +2.85 % ) and significant decreases in Alkphase B ( -8.7 % ) and serum NTx ( -16.7 % ) .", "output": [ "not found" ] }, { "id": "task180-185657d077cb49ae802f39353c7b349d", "input": "The SST-GP had higher efficacy than the LA-GP .", "output": [ "SST-GP, LA-GP" ] }, { "id": "task180-42bc9ffb87364daaa47350a6e0dbe54b", "input": "A physiotherapy service to an emergency extended care unit does not decrease admission rates to hospital : a randomised trial .", "output": [ "physiotherapy service" ] }, { "id": "task180-3ab1dbfc7657453589066e31121d03d4", "input": "Antioxidant supplementation and exercise-induced oxidative stress in the 60-year-old as measured by antipyrine hydroxylates .", "output": [ "not found" ] }, { "id": "task180-bd620c9fc5084511b0f4ceb8cde3b376", "input": "We investigated whether 5 to 20mg per week oral methotrexate could slow down disease progression in 44 patients with inclusion body myositis in a randomized double-blind placebo-controlled study over 48 weeks .", "output": [ "methotrexate" ] }, { "id": "task180-88999fd460784038aba65b82f07740f2", "input": "The findings indicate that this method of reporting symptoms and functioning status to primary care physicians did not significantly change patient outcomes .", "output": [ "not found" ] }, { "id": "task180-a2f400c0a85e4bb2bc7dec6da0bade7d", "input": "Followup was done with diuretic scanning at 3 , 6 , 9 and 12 months and then yearly , and thereafter with diuretic renography .", "output": [ "not found" ] }, { "id": "task180-cc215934598e47968a0a9531ea4c11f4", "input": "Trials involving larger patient populations will be necessary to confirm the results of this preliminary study and to determine the extent of clinical improvement , subpopulations benefited , role in heart failure therapeutics , and so forth .", "output": [ "not found" ] }, { "id": "task180-e5abd390da544ad29a0458b84e3f1731", "input": "573 patients who had unrecognized and untreated anxiety identified from the approximately 8,000 patients who completed the waiting room screening questionnaire .", "output": [ "not found" ] }, { "id": "task180-c1d074d65bff429b9d62301a54b0d34d", "input": "Gastric dysrhythmia in infants with gastrointestinal diseases measured by epigastric impedance .", "output": [ "not found" ] }, { "id": "task180-a11b55484e944c64a2777a8edc8ed677", "input": "Microalbuminuria itself predicts clinical proteinuria in nondiabetic and in diabetic people .", "output": [ "not found" ] }, { "id": "task180-e69214a26a304e58876c6fa6f8f5e64b", "input": "However , there is a lack of information regarding patient 's adherence to these recommendations in daily clinical practice .", "output": [ "not found" ] }, { "id": "task180-c670045af7bd4f54805adf1f27c8b503", "input": "Women who smoke and take oral contraceptives ( OCs ) have significantly increased risk of cardiovascular disease , but the exact mechanismsfor the increased risk are not known .", "output": [ "oral contraceptives" ] }, { "id": "task180-b85c2a21ae9a449580e2515b7504d0b3", "input": "Patients became significantly more depressed over time .", "output": [ "not found" ] }, { "id": "task180-f2e1f0465a764ca8b2690a25af0bdd67", "input": "Comparison of weakness progression in inclusion body myositis during treatment with methotrexate or placebo .", "output": [ "methotrexate, placebo" ] }, { "id": "task180-6093929b909b43139b300f7ae533a7c9", "input": "Treatment group participants were better able to suggest appropriate emotion-management strategies for story characters at post-intervention than at pre-intervention , whereas control participants were not .", "output": [ "not found" ] }, { "id": "task180-5ac2f843e25f45ad881a6394951b861c", "input": "The increase in plasma 6-keto-prostaglandin F1 alpha concentration was associated with an increase in serum HDL2 cholesterol concentration in the group taking regular exercise .", "output": [ "exercise" ] }, { "id": "task180-9f019aadad9c4a7ba119105d6147eb30", "input": "Results showed that cortisol and glucose levels were significantly high in 700 and 500 but not 3,000 mg l\u207b\u00b9 group compared to control .", "output": [ "not found" ] }, { "id": "task180-44cdc09c7a454916a99681a78f7480ad", "input": "Results suggest that rapid anesthesia with higher dose is better than slow anesthesia with lower dose for blood sampling in Beluga .", "output": [ "not found" ] }, { "id": "task180-5fe016fe09ee43039d432306ef202ca6", "input": "GABHS isolates were serotyped to distinguish bacteriological treatment failures ( and relapses ) from new acquisitions .", "output": [ "not found" ] }, { "id": "task180-6f0b1d692d704c479fc794d44eb25e21", "input": "This difference was not significant .", "output": [ "not found" ] }, { "id": "task180-d206c58b55e24e0cb7291ead626f7335", "input": "These data show that acute nicotine administration , in the form of nicotine gum , has no effect on cardiovascular or lipid stress reactivity in women .", "output": [ "not found" ] }, { "id": "task180-68985fa2092a4948b621f81044679f76", "input": "Participants were randomized to the SST or LA group .", "output": [ "SST, LA" ] }, { "id": "task180-4e77a1f622f642e48dbd99c654fd2486", "input": "A complete response , defined as no emesis with no need for another rescue antiemetic , during the first 3 h ( 0-3 h ) after anesthesia was 87 % with granisetron and 78 % with perphenazine ( P = 0.204 ) .", "output": [ "granisetron, perphenazine" ] }, { "id": "task180-3eed715f66f34337956264c47ced881e", "input": "Effectiveness of hygienic-dietary recommendations as enhancers of antidepressant treatment in patients with depression : study protocol of a randomized controlled trial .", "output": [ "hygienic-dietary" ] }, { "id": "task180-0d999515d2134a7794a1c9abc794617d", "input": "We used national data from the Medical Expenditure Panel Survey linked to the National Health Interview Survey and a study-specific survey to estimate the annual utilization and costs for health care , school , ASD-related therapy , family-coordinated services , as well as caregiver time in children aged 3 to 17 years , with and without parent-reported ASD .", "output": [ "not found" ] }, { "id": "task180-0989f05591d84d34930d295c83d23c0d", "input": "Amonafide was chosen for inclusion in the Cancer and Leukemia Group B ( CALGB ) master metastatic breast cancer protocol .", "output": [ "not found" ] }, { "id": "task180-f97b6072b8d74df685c1c37850af3eb6", "input": "In this adequately powered study , once-daily oral amoxicillin is not inferior to twice-daily penicillin V for the treatment and eradication of GABHS in children with pharyngitis .", "output": [ "amoxicillin, penicillin V" ] }, { "id": "task180-8cb0512271ae4af0b38ebb64810b5dd6", "input": "In this preliminary , open-labeled , randomized study , the effects of lime juice on the clinical and some laboratory characteristics of children with SCA were tested .", "output": [ "lime juice" ] }, { "id": "task180-809fc2b29db54453abaf5c18b1c55fce", "input": "The drug had demonstrated significant activity in preclinical studies and some activity in Phase I trials .", "output": [ "not found" ] }, { "id": "task180-b19c4aece47b423d8d769227a2fb7381", "input": "Ramipril prevents or delays the progression of albuminuria .", "output": [ "not found" ] }, { "id": "task180-17f1343d271b43a1a40a9a18911cf3ff", "input": "To compare maintenance epoetin alfa administered once every 3 weeks with continued weekly epoetin alfa for patients with cancer-associated anemia .", "output": [ "epoetin alfa" ] }, { "id": "task180-b1d86e63b24a49b38107c3fdfefbe15f", "input": "Epigastric impedance is a non-invasive method used to study gastric emptying time and gastric phasic activity .", "output": [ "not found" ] }, { "id": "task180-6e31b8ca250e4cc5af8aa773ba4c417e", "input": "Bayesian adaptive trials offer advantages in comparative effectiveness trials : an example in status epilepticus .", "output": [ "not found" ] }, { "id": "task180-b8192caf366e4e39b43045788dcb356b", "input": "This study was conducted to determine the long-term effect of flosequinan , a new orally administered arterial and venous dilator , on the clinical course of patients with moderate to severe congestive heart failure .", "output": [ "flosequinan" ] }, { "id": "task180-5bf8f7143cb04256be261ee4ffc5bf19", "input": "Intake of lime juice was recently demonstrated to facilitate clearance of the malaria parasite .", "output": [ "lime juice" ] }, { "id": "task180-0b615e9db3cf4add9f97531f3f939701", "input": "Subjects were randomly divided in two groups : supplementation ( n 11 ) with 100 mg dl-alpha-tocopheryl acetate , 200 mg ascorbic acid , and 2 mg beta-carotene , and placebo ( n 9 ) .", "output": [ "dl-alpha-tocopheryl acetate, ascorbic, beta-carotene, placebo" ] }, { "id": "task180-2db9568ca0dd47d1893d00c6ed9d8976", "input": "The addition of chronic vasodilator therapy with flosequinan to standard digitalis-diuretic regimens is capable of inducing clinical improvement in patients with moderate to severe chronic heart failure .", "output": [ "flosequinan" ] }, { "id": "task180-bb001cee456649a7b4a9cd4e39992b08", "input": "Eradication of GABHS , determined with follow-up throat cultures on days 3-6 , 12-16 and 26-36 .", "output": [ "not found" ] }, { "id": "task180-82b30ac9c35b45f98acc23f8c9b3194d", "input": "Rheumatic fever is a preventable chronic disease preceded by group A beta-haemolytic streptococcal ( GABHS ) pharyngitis .", "output": [ "not found" ] }, { "id": "task180-68b10a5bcf7f4a5d98e05a3959a64222", "input": "During the course of therapy , a modest improvement in the symptom scores and functional classification of the flosequinan-treated patients was observed .", "output": [ "flosequinan-treated" ] }, { "id": "task180-ad604f4a33114064bc9481741c704479", "input": "This report deals only with amonafide as a Phase II agent .", "output": [ "amonafide" ] }, { "id": "task180-dd1dfd2cd8c645588194f07bc1121275", "input": "However , there was no difference in the improvements made by children in the intervention and control conditions on facial expression and body-posture recognition measures .", "output": [ "not found" ] }, { "id": "task180-5540aca9d35f4cf492f76d468067a33f", "input": "In a 2 week randomized two-period crossover trial , 18 male adolescents consumed two diets , named white diet ( WD ) and brown diet ( BD ) , which were poor and rich in MRP , respectively .", "output": [ "white diet, brown diet" ] }, { "id": "task180-c8dcef12ce114abab477621a272d3d44", "input": "Our results suggest that both drugs were well tolerated in patients with AML or MDS who received chemotherapy and that the efficacy of itraconazole for prophylaxis against systemic fungal disease is not inferior to that of fluconazole .", "output": [ "itraconazole, fluconazole" ] }, { "id": "task180-3c12a88b7d1145eea2685276552dde63", "input": "Baseline microalbuminuria predicted subsequent clinical proteinuria for the study participants overall ( adjusted odds ratio [ OR ] , 17.5 ; 95 % confidence interval [ CI ] , 12.6 to 24.4 ) , in participants without diabetes ( OR , 16.7 ; 95 % CI , 8.6 to 32.4 ) , and in participants with diabetes ( OR , 18.2 ; 95 % CI , 12.4 to 26.7 ) .", "output": [ "not found" ] }, { "id": "task180-fe2f5cbcf870411681af950109094a21", "input": "Nonparametric bootstrap sampling of costs/QALY ratios established the 95 % CI around the estimates .", "output": [ "not found" ] }, { "id": "task180-04ce473ed733407aaa218da92fd55c67", "input": "MLMs indicated a slight increase in depressive symptoms over time in the sample as a whole .", "output": [ "not found" ] }, { "id": "task180-1fba01e655a9401b97a2642fcd13db6f", "input": "Aquatic exercisers reported equal ( QWB ) or better ( CHDR , HAQ , PQOL ) health-related quality of life compared with controls .", "output": [ "not found" ] }, { "id": "task180-ccc2cbe2eb274b5da9432bd511760e65", "input": "In the men taking regular exercise serum cholesterol concentrations increased 26 % more in the high density lipoprotein subfraction two ( HDL2 ) and decreased 31 % more in the subfraction three ( HDL3 ) and 9 % more in the low density lipoprotein fraction than in the control group .", "output": [ "not found" ] }, { "id": "task180-15c1eeeb6250468ebc4cbe7451ffc332", "input": "Outcomes improved with regular class attendance .", "output": [ "not found" ] }, { "id": "task180-2d508a13938a435e8e66b189aeedc8de", "input": "Any progression of albuminuria ( defined as new microalbuminuria or new clinical proteinuria ) occurred in 1859 participants ; 1542 developed new microalbuminuria , and 317 participants developed clinical proteinuria .", "output": [ "not found" ] }, { "id": "task180-5c8ec7888a8a432b8105b7d755e8fc4d", "input": "Participating physicians were randomized to either the demonstration or the control arm , and patients were assigned to a study arm based on the randomization of their physicians .", "output": [ "not found" ] }, { "id": "task180-e19af42b6930449a97fc8d6a1a5bdadd", "input": "Approximately two thirds were smokers and were randomized to be tested after either a 12-hr nicotine deprivation or administration of nicotine gum .", "output": [ "nicotine deprivation, nicotine" ] }, { "id": "task180-a60653c2db1f4b4b86ab78536673624f", "input": "The effects of the high intake of Maillard reaction products ( MRP ) on calcium availability in adolescents and across Caco-2 cell monolayers were examined .", "output": [ "Maillard reaction products, MRP" ] }, { "id": "task180-27f6cec4b9bd4ce2896fdd0199e9c25e", "input": "Previous analyses that focused on health care underestimated this economic burden , particularly for school systems .", "output": [ "not found" ] }, { "id": "task180-badb2176acde4e4f915bcc18926a129c", "input": "Role of posterior tibial nerve stimulation in the treatment of refractory monosymptomatic nocturnal enuresis : a pilot study .", "output": [ "posterior tibial nerve stimulation" ] }, { "id": "task180-3f09b891842945dfb010584d561e3a51", "input": "No change was evident in group 2 .", "output": [ "not found" ] }, { "id": "task180-d4f60be67dc54cb88733ebe1675fcee1", "input": "To develop a cycle-based risk prediction model for neutropenic complications ( NC ) during chemotherapy with doxorubicin ( DOX ) or a pegylated liposomal formulation ( PLD ) for patients with metastatic breast cancer ( MBC ) .", "output": [ "doxorubicin, pegylated liposomal formulation" ] }, { "id": "task180-14bf10dd9461475c84cd927bf24fee2b", "input": "There was no difference in the proportion of patients requiring transfusions during the study ( 23 % in 40K arm and 18 % in 120K arm , P = .22 ) or specifically during the maintenance phase ( 13 % in 40K arm v 15 % in 120K arm , P = .58 ) .", "output": [ "not found" ] }, { "id": "task180-770cc612870e4850811e39683694c7c2", "input": "However , no study to date has examined whether or not they understand conceptual metaphors ( i.e . mappings between conceptual structures ) , which could be the building blocks of metaphoric thinking and understanding .", "output": [ "not found" ] }, { "id": "task180-00bc1b1832924b4693de9e72a73a03d3", "input": "Adherence to lifestyle recommendations by patients with depression .", "output": [ "not found" ] }, { "id": "task180-95c6b7a58e3f45e2a97dfe95a072a7d2", "input": "After induction of complete remission , patients were randomized to the bestatin group ( 30 mg/bw per os ( po ) daily ) and the control group .", "output": [ "bestatin, control" ] }, { "id": "task180-01144305f942464a920422fcb04aa5c7", "input": "The 101 eligible cases ( bestatin : 48 , control : 53 ) were analyzed ; the bestatin group achieved longer remission than the control group and a statistically significant longer survival .", "output": [ "bestatin" ] }, { "id": "task180-17262b935f0c4062acf3651e8962b08f", "input": "In assessing the acute functional effect of bronchodilators , \u0394sRAW-based criterion is preferable to FEV1-FVC-based criteria , being more closely related to bronchodilator-induced improvements of lung mechanics and dyspnea at rest .", "output": [ "not found" ] }, { "id": "task180-19940ac3ad7644569b96740c56c87c22", "input": "[ The effect of ionic and nonionic x-ray contrast media on myocardial perfusion and myocardial function ] .", "output": [ "ionic, nonionic" ] }, { "id": "task180-ee73c74fd9a84d39bbc3b4c06f3a314c", "input": "To compare a collaborative approach , the Three Component Model ( 3CM ) , with usual care for treating PTSD in primary care .", "output": [ "Three Component Model, 3CM" ] }, { "id": "task180-ad677f6c81f24a7bac7a872db96c6434", "input": "Patients under each drug condition were compared with controls to assess normalization effects .", "output": [ "not found" ] }, { "id": "task180-7b668d7e1aa8481c8ad887483ab49f6f", "input": "We present a novel Bayesian adaptive comparative effectiveness trial comparing three treatments for status epilepticus that uses adaptive randomization with potential early stopping .", "output": [ "not found" ] }, { "id": "task180-bfaa069e565d41a2983f3b9c7cb80856", "input": "Two weeks seems to be a sufficient duration to allow functional restoration across the ureteropelvic junction after endopyelotomy and decrease stent related complications .", "output": [ "not found" ] }, { "id": "task180-197c2e0576ce4d5b8698361bd3b1de34", "input": "There were 4 cases with possible systemic fungal infection in the itraconazole group , and there were 8 possible and 3 probable cases in the fluconazole group .", "output": [ "itraconazole, fluconazole" ] }, { "id": "task180-97743cb904994f2d87f33fe07219dd23", "input": "Toxicity was primarily hematological and bimodal : 32 % had grade 3 or 4 leukopenia and 24 % had grade 3 or 4 thrombocytopenia ; 22 % had no leukopenia and 44 % had no thrombocytopenia .", "output": [ "not found" ] }, { "id": "task180-242b782fedc14b5abfb6682aacc92ab7", "input": "Factors with a P value of < or =0.25 within a cycle were included in a generalized estimating equations regression model .", "output": [ "not found" ] }, { "id": "task180-3883792883f34c46a6ad61de6b919539", "input": "However , deterioration in some responders with time suggests the need for maintenance protocols .", "output": [ "not found" ] }, { "id": "task180-326a8a94042c4ef6af075d31168c5e6e", "input": "High-functioning autism ( HFA ) is characterized by persistent impairment in social interaction despite the absence of mental retardation .", "output": [ "not found" ] }, { "id": "task180-3cb4962d56914b839424bc7f1497e917", "input": "The primary outcome was defined as an improvement of 2 points in error rates for facial emotion labeling ( DANVA2 ) from baseline .", "output": [ "not found" ] }, { "id": "task180-3d1c17af6dbc4ee8b91eef861e051259", "input": "The upper 95 % CL for the differences in positive cultures between the antibiotics was 4.9 % at days 3-6 , 6.5 % at days 12-16 and 8.5 % at days 26-36 .", "output": [ "not found" ] }, { "id": "task180-ee52b1c40f664a03a0d821dedec15810", "input": "Blood samples were collected after these periods , when fish were immobile and reached stage 4 anesthesia .", "output": [ "not found" ] }, { "id": "task180-061a821d23c741e484e4ffbb5face12e", "input": "Individuals with autism spectrum disorder ( ASD ) have difficulty comprehending metaphors .", "output": [ "not found" ] }, { "id": "task180-46ce21a4eea744d7ad4b6d79804398ea", "input": "Identifying patients at high risk for neutropenic complications during chemotherapy for metastatic breast cancer with doxorubicin or pegylated liposomal doxorubicin : the development of a prediction model .", "output": [ "doxorubicin, pegylated liposomal doxorubicin" ] }, { "id": "task180-4a5c33bd63e54ddb80075c625125a127", "input": "The drug is extensively metabolized and detected in plasma and urine .", "output": [ "not found" ] }, { "id": "task180-ddbf055cc8c7470688f302dd5ec1a81b", "input": "Since the results were essentially identical between the techniques , it seems that comparable pathophysiological factors affect TLCO during breath holding and constant exhalation .", "output": [ "breath holding, constant exhalation" ] }, { "id": "task180-b2f4482346eb42e9a3a5e1338828bf61", "input": "Women who also exercised had additional increases in BMD at the femoral neck ( +0.29 % ) , total hip ( +0.34 % ) , spine ( +0.23 % ) , total radius ( +0.30 % ) , and additional decreases in Alkphase B ( -2.4 % ) and Serum NTx ( -6.5 % ) .", "output": [ "exercised" ] }, { "id": "task180-0d1afd1fd9904fcd9303ab3edfa4c910", "input": "Anti-emetic efficacy of prophylactic granisetron compared with perphenazine for the prevention of post-operative vomiting in children .", "output": [ "granisetron, perphenazine" ] }, { "id": "task180-406daa24b6754e049594745dbad79739", "input": "Gastrointestinal symptoms have been reported in association with myoelectrical dysrhythmia , where different types of gastric electrical activity have been described .", "output": [ "not found" ] }, { "id": "task180-dad7f0b1e695454da0441eb809bc8d09", "input": "Escalation and reduction in dose was mandated dependent on hematotoxicity or lack thereof .", "output": [ "not found" ] }, { "id": "task180-67a164f914ef4b6b980a553760cc0d55", "input": "A precycle risk score from > or =25 to < 40 for a given patient was identified as being the optimal threshold for sensitivity ( 58.0 % ) and specificity ( 78.7 % ) .", "output": [ "not found" ] }, { "id": "task180-2ec0efba3e14498b9a60b58ddd550899", "input": "These results are not concordant with the view that intentional smoking abstinence exacerbates depressive symptoms .", "output": [ "not found" ] }, { "id": "task180-97d4d9534c8946829becb3f04fdcd307", "input": "Eligible patients were children and adolescents with HFA .", "output": [ "not found" ] }, { "id": "task180-1c383eaa94024c0a8f09c22a9fc3c7d0", "input": "A symptom based questionnaire was administered to all patients at stent removal .", "output": [ "not found" ] }, { "id": "task180-b48b555ba7534875a1564999dbb08a9d", "input": "In accordance , calcium bioavailability in adolescents did not vary between the diets ( % WD = 40.4 +/- 5.1 , BD % = 38.2 +/- 3.6 ) .", "output": [ "not found" ] }, { "id": "task180-130fcc42d49541248024b204349cf6da", "input": "The Hb increment is somewhat greater with continued weekly epoetin alfa .", "output": [ "epoetin alfa" ] }, { "id": "task180-dfe8a3d6c65e4c03817116a60666ec07", "input": "Measurement of transfer factor during constant exhalation .", "output": [ "not found" ] }, { "id": "task180-2957f45993734e0fb0bf847470d65ba3", "input": "Inclusion criteria were known vascular disease or diabetes plus one other cardiovascular risk factor , exclusion criteria included heart failure or known impaired left ventricular function , dipstick-positive proteinuria ( > 1+ ) , and serum creatinine > 2.3 mg/dl ( 200 microM ) .", "output": [ "not found" ] }, { "id": "task180-0d1eb4614915477f8a97df9924308a52", "input": "Antipyrine reacts quickly with hydroxyl radicals to form para- and ortho-hydroxyantipyrine .", "output": [ "not found" ] }, { "id": "task180-7ca6b3ba21d14b98a94101c18e453e9a", "input": "For the QoL-Colostomy , however , there was no significant difference between the control and experimental groups .", "output": [ "not found" ] }, { "id": "task180-d830fa31688f424599629e706eb627c4", "input": "Language outcome in autism : randomized comparison of joint attention and play interventions .", "output": [ "attention, play" ] }, { "id": "task180-06c9e253699141a8adfa6c64dc19f003", "input": "Time-varying smoking abstinence predicts lower depressive symptoms following smoking cessation treatment .", "output": [ "not found" ] }, { "id": "task180-e6dbff1df64048a39b29b112597391b7", "input": "Additionally , because prolonged breath holding is not required , measurements can readily be made in dyspnoeic patients .", "output": [ "not found" ] }, { "id": "task180-9375b59edd834ac2b0f31e0cee6ef854", "input": "Of the group 2 patients 64 % preferred 2 weeks of stenting .", "output": [ "not found" ] }, { "id": "task180-a5aa58a2417a461c9677a34b16a96b4c", "input": "We conclude that amonafide is somewhat active in previously untreated breast cancer patients .", "output": [ "amonafide" ] }, { "id": "task180-8226eb2b74b947cb9a117c9d996233d3", "input": "The prophylactic effect of itraconazole capsules and fluconazole capsules for systemic fungal infections in patients with acute myeloid leukemia and myelodysplastic syndromes : a Japanese multicenter randomized , controlled study .", "output": [ "itraconazole, fluconazole" ] }, { "id": "task180-c227beded8304977921162c784c42fb1", "input": "People without and with diabetes who are at high risk for cardiovascular disease are also at risk for a progressive rise in albuminuria .", "output": [ "not found" ] }, { "id": "task180-5be400c77bc64d48a80e2bc06c316655", "input": "Before and after the 12 week supplementation period , subjects cycled for 45 min at submaximal intensity ( 50 % maximal workload capacity ) .", "output": [ "cycled" ] }, { "id": "task180-85dc9c3337da4630a4685243f62a89f9", "input": "Participants were 236 heavy drinking smokers in a randomized clinical trial testing the efficacy of incorporating brief alcohol intervention into smoking cessation treatment .", "output": [ "not found" ] }, { "id": "task180-a22dd587f0b74a7793fef256986b5fff", "input": "Posterior tibial nerve stimulation can be a viable treatment option in some patients with refractory monosymptomatic nocturnal enuresis .", "output": [ "not found" ] }, { "id": "task180-10a800b3a18e4c1485bee55abcbb0232", "input": "Assessments of JA skills , SP skills , mother-child interactions , and language development were collected at 4 time points : pre- and postintervention and 6 and 12 months postintervention by independent testers .", "output": [ "not found" ] }, { "id": "task180-e40536f9595540589257da4d5f995cca", "input": "MAIN MEASURES PTSD symptom severity was the primary outcome .", "output": [ "not found" ] }, { "id": "task180-14c53f34157b4fe0aaa2a3bf0ecd1c85", "input": "The rate of height gain was no different for treatment and placebo groups .", "output": [ "not found" ] }, { "id": "task180-766e884cef054a3fb3e5da3d46ea4d86", "input": "Fluoxetine therefore has inverse effects on mPFC activation in ASD and ADHD during reversal learning , suggesting dissociated underlying serotonin abnormalities .", "output": [ "not found" ] }, { "id": "task180-1ae5a475087a4ed6aa8f531e00126927", "input": "The effect of weight training on bone mineral density and bone turnover in postmenopausal breast cancer survivors with bone loss : a 24-month randomized controlled trial .", "output": [ "not found" ] }, { "id": "task180-84be7c1b521a459d8bdfc0dd0387661d", "input": "353 children with positive throat swabs for GABHS were randomised to amoxicillin ( n = 177 ) or penicillin V ( n = 176 ) .", "output": [ "amoxicillin, penicillin V" ] }, { "id": "task180-a323eae09f5c4f8b81d023c1d032f3be", "input": "The trial will enroll 720 unique patients in emergency departments and uses a Bayesian adaptive design .", "output": [ "not found" ] }, { "id": "task180-48718c759b0d48099cc5865685c59933", "input": "Changes in symptomatology , exercise performance , and left ventricular function were assessed serially during the two-month treatment period .", "output": [ "not found" ] }, { "id": "task180-5e10eac912a94e158b40711a25554450", "input": "When response was analyzed by hematological toxicity , there was a 35.7 % response if patients had leukopenia grade 3/4 ( versus 8.3 % , P = 0.08 ) .", "output": [ "not found" ] }, { "id": "task180-288823d8fe764a458e1ca709b1ea1985", "input": "However , among OC users , nonsmokers had significantly greater heart rate and diastolic blood pressure reactivity to stress .", "output": [ "not found" ] }, { "id": "task180-1e179e9ca9af49e4b58b67aec0697ff5", "input": "Patients had to have histologically documented measurable breast cancer and a performance status of 0-1 .", "output": [ "not found" ] }, { "id": "task180-c10ef7d6ba1043aa9c0c449a426f993d", "input": "Participants were 58 children ( 46 boys ) with autism between 3 and 4 years of age .", "output": [ "not found" ] }, { "id": "task180-8721eee9a97a433f972ec5e7301d4860", "input": "One of the reasons physiotherapy services are provided to emergency departments ( EDs ) and emergency extended care units ( EECUs ) is to review patients ' mobility to ensure they are safe to be discharged home .", "output": [ "not found" ] }, { "id": "task180-9a0f65e6ea2c4179a220bade94c9d090", "input": "To estimate the associations between autism spectrum disorder ( ASD ) diagnoses and service use , caregiver time , and cost outcomes .", "output": [ "not found" ] }, { "id": "task180-59445bde2a824f808b21eb07df6c6a81", "input": "Individuals with ASD performed at greater than chance levels on both metaphor types , although their performance was lower than TD participants .", "output": [ "not found" ] }, { "id": "task180-1c77d5e5e79043feb2380a0b1629943b", "input": "During the first 6 months following a planned quit attempt , being abstinent in a particular week appears to be associated with lower levels of concurrent depressive symptoms .", "output": [ "not found" ] }, { "id": "task180-2d79c2d8bc9b47a2b3f2b736b3101157", "input": "A pilot study on the effect of progressive muscle relaxation training of patients after stoma surgery .", "output": [ "progressive muscle relaxation training" ] }, { "id": "task180-082fca162e3e48d4a180415454b518c9", "input": "Improvement in outcomes appeared to be more closely associated with the patient 's severity of psychological distress .", "output": [ "not found" ] }, { "id": "task180-979df418436246a6afe5680a07ed498d", "input": "Adverse events did not significantly differ in the 2 groups .", "output": [ "not found" ] }, { "id": "task180-481ee420e0f8429b849dd39bd40d60c5", "input": "Rates of responses in patients adequately dosed ( i.e. , with significant hematotoxicity ) with amonafide ranged from 35 to 50 % .", "output": [ "amonafide" ] }, { "id": "task180-2647e59f9cff4e80b80a034674edc693", "input": "Ramipril reduced the risk for any progression ( OR , 0.87 ; 95 % CI , 0.78 to 0.97 ; P = 0.0146 ) .", "output": [ "not found" ] }, { "id": "task180-9f7bc6f80ca5419e936430a7649fe01b", "input": "Assessment of acute bronchodilator effects from specific airway resistance changes in stable COPD patients .", "output": [ "bronchodilator" ] }, { "id": "task180-42b43bfa664f4779b195684ec7546341", "input": "A pathologic result was found in 90 % of the patients .", "output": [ "not found" ] }, { "id": "task180-51652fe7e2694690ae2736058194971b", "input": "A multi-component social skills intervention for children with Asperger syndrome : the Junior Detective Training Program .", "output": [ "social skills" ] }, { "id": "task180-b4244be4c5834d9cba974b8ed3f5af35", "input": "One third were nonsmokers .", "output": [ "not found" ] }, { "id": "task180-2044529dea7149d7b49a7aefb4d8ae10", "input": "Phase III study of two different dosing schedules of erythropoietin in anemic patients with cancer .", "output": [ "erythropoietin" ] }, { "id": "task180-111339cf73f4403294f9ecb0c313b275", "input": "Differences between groups for use of community healthcare resources , return to usual work/home/leisure activities and satisfaction with their EECU care were small and not significant .", "output": [ "not found" ] }, { "id": "task180-e17d4103ea454a5f8c12553cfc3b74a7", "input": "Results indicated that , among OC nonusers , there was no effect of smoking status or nicotine administration on cardiovascular reactivity .", "output": [ "not found" ] }, { "id": "task180-28a142a5a74647e4a938ad89219cc50b", "input": "Randomized trial of 20-week aquatic classes .", "output": [ "aquatic classes" ] }, { "id": "task180-ef920c42a3d64ddfba818eb5172be974", "input": "Exhalation TLCO ( TLCO , ex ) was compared with the standard ( Jones and Meade ) 10 second breath holding TLCO ( TLCO , bh ) in 100 consecutive patients .", "output": [ "not found" ] }, { "id": "task180-50fa16096c2d4fd19773568bb568052d", "input": "The response rate was 18 % , including one complete response .", "output": [ "not found" ] }, { "id": "task180-5362e2fcba7f48e69d990f0fd3b2d299", "input": "The pain in sickle cell anemia ( SCA ) is often triggered by dehydration , acidosis , and fever that are usually due to malaria .", "output": [ "not found" ] }, { "id": "task180-f12fa0141be84e4986f7135eb625bbba", "input": "There were no significant differences in serum levels of cholesterol , total protein , lactate dehydrogenase , aspartate aminotransferase , alanine aminotransferase , Na\u207a , Cl\u207b , K\u207a , and Ca\u00b2\u207a .", "output": [ "not found" ] }, { "id": "task180-de83ef59f6af4e578005c5c1b78b3f9f", "input": "A set of five factors were found to consistently predict depression at the following assessment .", "output": [ "not found" ] }, { "id": "task180-900174af922844e39933becddf6a8ec7", "input": "Necessary but not sufficient : the effect of screening and feedback on outcomes of primary care patients with untreated anxiety .", "output": [ "not found" ] }, { "id": "task180-7b593d3cd3dd4c2a94e332c54d25b953", "input": "Mean followup was 22.3 ( range 12 to 36 ) and 21.3 months ( range 12 to 35 ) in groups 1 and 2 , respectively .", "output": [ "not found" ] }, { "id": "task180-82cc2333c6644564a59c9ce67910b6d3", "input": "Children presenting with GABHS pharyngitis were randomised to oral amoxicillin 1500 mg QD ( or 750 mg if bodyweight was < or=30 kg ) or to oral penicillin V 500 mg BID ( or 250 mg if bodyweight was < or=20 kg ) for 10 days .", "output": [ "amoxicillin, penicillin V" ] }, { "id": "task180-e4698b9ce4da438db83a8f221490c9bf", "input": "After treatment 11 group 1 patients ( 78.6 % ) had a partial or full response to posterior tibial nerve stimulation but only 2 ( 14.3 % ) in group 2 had a partial response ( p = 0.002 ) .", "output": [ "posterior tibial nerve stimulation" ] }, { "id": "task180-47369cf16bcf455daebc305764885ffe", "input": "Treatment failures ( including relapses ) occurred at each visit in 5.8 % , 12.7 % and 10.7 % of amoxicillin recipients and 6.2 % , 11.9 % and 11.3 % of penicillin V recipients , respectively .", "output": [ "amoxicillin, penicillin V" ] }, { "id": "task180-d20fb7de41bf452192408051f5c4019d", "input": "QoL increased in the SST Group in the dimension of school environment , as a marker of the transfer of skills acquired in the treatment setting to their use in the community .", "output": [ "SST" ] }, { "id": "task180-e018cece2dcf47509aaae0e762cf779e", "input": "Patients randomly assigned to the 40K arm were more likely to have a > or = 2 or > or = 3 g/dL hemoglobin ( Hb ) increment , were more likely to have a drug dose held because of high Hb , and had higher mean end-of-study Hb levels .", "output": [ "40K arm" ] }, { "id": "task180-19b0244683d9478da97b7f570d9d69ee", "input": "Eighteen patients who had undergone stoma surgery were assessed with respect to their anxiety level and self-reported quality of life ( QoL ) on three occasions ; namely , immediately after surgery , 5 weeks after surgery , and 10 weeks after surgery .", "output": [ "not found" ] }, { "id": "task180-965ca6828a844d919f3075f13fdef5cb", "input": "One hundred eighty-three patients were assigned to the 40K arm , and 182 were assigned to the 120K arm .", "output": [ "not found" ] }, { "id": "task180-679623db1e0c4b949ca78273e08115cb", "input": "Among the 113 children with SCA studied in two hospitals , the 58 receiving lime treatment had lower rates of significant painful episodes than the 55 without lime ( 37 versus 83 crises in 6 months , and 0.64\u00b10.11 versus 1.51\u00b10.34 average rates per child , p < 0.001 ) .", "output": [ "lime" ] }, { "id": "task180-d029893ddcd94bfebc73fc16de29943c", "input": "By lowering peripheral airway smooth muscle tone , bronchodilators should decrease dynamic hyperinflation , gas trapping , and possibly dyspnea at rest .", "output": [ "bronchodilators" ] }, { "id": "task180-e9e389f2129b4bb38e4e2bdfcf67fea4", "input": "The Junior Detective Training Program appeared to be effective in enhancing the social skills and emotional understanding of children with AS .", "output": [ "Junior Detective Training Program" ] }, { "id": "task180-fa2bdb38b3d8442bb00f192f71745091", "input": "Transfer factor of the lung for carbon monoxide ( TLCO ) was measured by a new method based on analysis of the ratio of the concentrations of carbon monoxide to an inert gas ( methane ) relative to lung volume during a constant exhalation .", "output": [ "not found" ] }, { "id": "task180-7e2ecd47f7df46d3b436d3c7bd11214d", "input": "Cost per quality-adjusted life year ( QALY ) gained was estimated using trial data .", "output": [ "not found" ] }, { "id": "task180-58ce6a053f4547758ef94d7dcb29e245", "input": "3CM participants also had more mental health visits and higher outpatient pharmacy costs .", "output": [ "not found" ] }, { "id": "task180-fb052c8b158349af9521f99c09741ea6", "input": "We have compared the efficacy of granisetron with perphenazine in the prevention of vomiting after tonsillectomy with or without adenoidectomy in children .", "output": [ "granisetron, perphenazine" ] }, { "id": "task180-dd094282d0d94706b7301fb88b7ca092", "input": "Further studies will incorporate individualized dosing based on pretreatment acetylator phenotyping .", "output": [ "not found" ] }, { "id": "task180-5ade2374a16e4662bfeb73510125c6ae", "input": "Depression , functioning , perceived quality of care , utilization , and costs were secondary outcomes .", "output": [ "not found" ] }, { "id": "task180-ee0260d784084ec5982ad128de27d1fb", "input": "Regression analyses estimated the association between ASD diagnosis and cost , controlling for child gender , age , race/ethnicity , insurance status , household income , country region and urban/rural classification , and non-ASD-related illnesses .", "output": [ "not found" ] }, { "id": "task180-2438303ea8e844709e7beb6f57dc1073", "input": "No clinically serious adverse events were observed in any of the groups .", "output": [ "not found" ] }, { "id": "task180-02c23d24125a4bd28ba03d35f04dddc0", "input": "In each group 26 patients were available for evaluation .", "output": [ "not found" ] }, { "id": "task180-6f2fe6637d344ba29c858ae8f2dd13b3", "input": "Outcome measures will be assessed before and after the 6 month intervention period .", "output": [ "not found" ] }, { "id": "task180-cac3bd5665014b14b94737d95ef45411", "input": "Sample size was based on 80 % power to reject the null hypothesis that the cost/QALY gained would not exceed $ 50,000 .", "output": [ "not found" ] }, { "id": "task180-a12e5b14ee0a4d63b17f20c4caba6e41", "input": "All urodynamic parameters significantly improved in group 1 .", "output": [ "not found" ] }, { "id": "task180-70258ec4290b4e43ad4839e924ff86df", "input": "There were no differences between 3CM and usual care in symptoms or functioning .", "output": [ "not found" ] }, { "id": "task180-a32a0cdb1ccd488eb02b3ed65e8287c3", "input": "Among the domains of WHOQoL , a significant difference was shown in physical health/independence and general perception of QoL , with the experimental group demonstrating better functioning .", "output": [ "not found" ] }, { "id": "task180-223b4b059dd74c36a8d77fba74c119db", "input": "The question of whether abstinence during the months following a planned quit attempt exacerbates or improves depressive symptoms is an important clinical issue .", "output": [ "not found" ] }, { "id": "task180-c7a5e830447f4f1cb1c34f77f4c4592a", "input": "This report is restricted to 7674 participants with albuminuria data at baseline and at follow-up .", "output": [ "not found" ] }, { "id": "task180-0c08045aff864360913b04f9953b574f", "input": "Subjects who were > or =50 % adherent to exercise were less likely to lose BMD at the total hip ( chi-square [ 1 ] = 4.66 , p = 0.03 ) and femoral neck ( chi-square [ 1 ] = 4.63 , p = 0.03 ) .", "output": [ "not found" ] }, { "id": "task180-b1bfbb21d4e94324902fd15835dd23e0", "input": "Progress in the ability to recognize anger in the SST Group was due to better recognition of low intensity stimuli on adult faces .", "output": [ "SST" ] }, { "id": "task180-3759650ddaa546bb9b10d151320a67b0", "input": "Sixty healthy women , half of whom had been using OCs for at least the previous 6 months , participated in the study .", "output": [ "not found" ] }, { "id": "task180-d7b03039730b45989673568a2f81bac7", "input": "The study aimed to investigate the effectiveness of a new multi-component social skills intervention for children with Asperger syndrome ( AS ) : The Junior Detective Training Program .", "output": [ "not found" ] }, { "id": "task180-4c1556b5c6824dbe8f28973fe445bda3", "input": "Eligible patients were randomly assigned at enrollment to receive three weekly doses of epoetin alfa 40,000 U subcutaneously ( SC ) , followed by either standard weekly epoetin alfa ( 40K arm ) or 120,000 U of epoetin alfa ( 120K arm ) SC every 3 weeks for 18 additional weeks .", "output": [ "epoetin alfa" ] }, { "id": "task180-96e29eb69db54c7ab2fe3355c51883a1", "input": "A 20-min set of audiotaped instructions on progressive muscle relaxation training ( PMRT ) was given to the patients in the experimental group for home practice .", "output": [ "progressive muscle relaxation training, PMRT" ] }, { "id": "task180-96033354cf104f4588865e3946008b41", "input": "A greater proportion of children in the ASD group used special educational services ( 76 % vs. 7 % in the control group , P < .05 ) .", "output": [ "not found" ] }, { "id": "task180-9a2550fa61ed4a0cb90eb351d99c1abb", "input": "In order to investigate the effect of anesthesia on serum parameters , Beluga , Huso huso ( L. ) were blood-sampled immediately without anesthesia ( control ) or subjected to following anesthesia procedure : 40 , 120 , and 240 s exposure to 3,000 , 700 , and 500 mg l\u207b\u00b9 clove solution , respectively .", "output": [ "anesthesia" ] }, { "id": "task180-132ddbf9bafd48bb8b1b484f45499c04", "input": "Participants assigned to 3CM also received telephone care management .", "output": [ "not found" ] }, { "id": "task180-4b2a55139767491994108b540095b3ef", "input": "They wore a wrist-watch-like actimetry sensor to measure physical activity and sun exposure 24 hours a day .", "output": [ "not found" ] }, { "id": "task180-7a4645f575654bf8a8f3229824e551ae", "input": "The relation was equally strong in patients with severe pulmonary disease ; for patients with FEV1 < 1.51 the mean difference was 0.21 ( 0.80 ) mmol/min/kPa .", "output": [ "not found" ] }, { "id": "task180-1dfcca712f8b4f0ab4ceaa827c7c0aad", "input": "Stent related symptoms were present in a good proportion of patients in groups 1 and 2 but there was a significant difference in the incidence of urinary tract infections ( 11.5 % versus 38.1 % , p = 0.04 ) .", "output": [ "not found" ] }, { "id": "task180-89b531e893ad4c0aaf88977f0b59a27e", "input": "Effect of antipyretic drugs in children with malaria .", "output": [ "antipyretic" ] }, { "id": "task180-1f0deee845894b5b933a81986e3151ac", "input": "A tendency towards increased plasma 6-keto-prostaglandin F1 alpha concentration and decreased serum thromboxane B2 concentration was found during the period of regular exercise , but prostaglandin E2 concentrations remained unchanged .", "output": [ "not found" ] }, { "id": "task180-315ac497fd2c40309358d7d442b9d089", "input": "CALGB 8642 randomizes previously untreated metastatic breast cancer patients either to one of several Phase II agents given for up to four cycles and then followed by standard cyclophosphamide-doxorubicin-5-fluorouracil , or to immediate treatment with standard cyclophosphamide-doxorubicin-5-fluorouracil .", "output": [ "cyclophosphamide-doxorubicin-5-fluorouracil" ] }, { "id": "task180-263057fa5929458a87c5e21565f61110", "input": "RESPECT-PTSD : re-engineering systems for the primary care treatment of PTSD , a randomized controlled trial .", "output": [ "not found" ] }, { "id": "task180-b2d8e9243f9848c78b919ba7def866c3", "input": "There was a 50 % response if patients had thrombocytopenia grade 3/4 ( versus 7.1 % , P = < 0.01 ) .", "output": [ "not found" ] }, { "id": "task180-7c35f7cf2c5444fe99a9e69de62213a5", "input": "Ascaris and growth rates : a randomized trial of treatment .", "output": [ "not found" ] }, { "id": "task180-b5ce8991d1244559a954217cce7b1940", "input": "Bestatin is shown to be a clinically useful drug for immunotherapy of adult ANLL , since it has prolonged survival and remission especially in elderly patients , with few side-effects .", "output": [ "not found" ] }, { "id": "task180-02a9bd0ff917408d948529151fe3b4b8", "input": "The purpose of this study was to examine the effect of chronic cigarette smoking , acute nicotine administration , and OC use on cardiovascular and lipid reactivity .", "output": [ "not found" ] }, { "id": "task180-57c901079fc640e3a87f96238259acfe", "input": "Inherent stent related problems warrant a minimum possible duration of stenting without compromising the results of endopyelotomy .", "output": [ "not found" ] }, { "id": "task180-40b49260fdfe4dc5baa76518e9d38f6c", "input": "Care managers received supervision from a psychiatrist .", "output": [ "not found" ] }, { "id": "task180-024324abe28643148dd7d3b9f35108f2", "input": "Since this new technique is based solely upon exhalation , anomalies associated with inspiration and breath holding do not affect results .", "output": [ "not found" ] }, { "id": "task180-f59e3bf636d04c85bf1241d3c9d4b7e0", "input": "This was a randomised non-inferiority trial carried out in a school-based clinic in New Zealand .", "output": [ "not found" ] }, { "id": "task180-dd73ea059faa4765944b946307643817", "input": "Aquatic exercise exceeded $ 50,000 per QALY gained using the community-weighted outcome but fell below this arbitrary budget constraint when using the participant-weighted measure .", "output": [ "not found" ] }, { "id": "task180-667c44f98d19423e92fff3152948fd04", "input": "It was therefore sought to determine whether regular intake of lime juice will ameliorate crisis , especially recurrent bone pain .", "output": [ "lime juice" ] }, { "id": "task180-4d431ae459574f3a98369c1a15a6967a", "input": "While long-term flosequinan administration also effected a progressive increase in resting heart rate , it did not consistently improve indices of left ventricular systolic function .", "output": [ "flosequinan" ] }, { "id": "task180-bc82e47fce524e2180b0223571008c5e", "input": "Among the 273 children who were seen and weighed at the one-year follow-up visit , the rate of weight gain was 8 per cent greater for those receiving levamisole than for placebo-treated controls ( p = .06 ) .", "output": [ "levamisole, placebo-treated" ] }, { "id": "task180-66dc0114780049f2afc7821c00fb0608", "input": "At 3-month followup the number of patients with a partial or full response in group 1 had decreased from 11 ( 78.6 % ) to 6 ( 42.9 % ) .", "output": [ "not found" ] }, { "id": "task180-f02bce7caff9427587932a77a3e48873", "input": "A mixed-model health maintenance organization serving approximately 110,000 enrollees in central Colorado .", "output": [ "not found" ] }, { "id": "task180-cf3d4dc11de543a3b04d508ca709770f", "input": "Economic burden of childhood autism spectrum disorders .", "output": [ "not found" ] }, { "id": "task180-57f6184be9c9446498decb7791e117d1", "input": "Confidence intervals around these ratios suggested wide variability of cost effectiveness of aquatic exercise .", "output": [ "aquatic exercise" ] }, { "id": "task180-7474bd8aa4764e02bc721c7d98703e78", "input": "There is an increasing amount of evidence showing that physical activity and sun exposure are effective coadjuvant treatments for patients with mild to moderate depression .", "output": [ "physical activity, sun exposure" ] }, { "id": "task180-2041086334b54c7aa7343f4a8cfe70d4", "input": "This is the first study to document the importance of illness perceptions in recent onset RA .", "output": [ "not found" ] }, { "id": "task180-cabb53c249944cbabc0bf4b5c0514284", "input": "However , this approach can not account for potential third variables between participants that may affect both smoking and depression .", "output": [ "not found" ] }, { "id": "task180-cd96e4657d214773b7b965f29d567806", "input": "Once-daily amoxicillin versus twice-daily penicillin V in group A beta-haemolytic streptococcal pharyngitis .", "output": [ "amoxicillin, penicillin" ] }, { "id": "task180-4770d45fbca14dbca06d73c91d6c64fb", "input": "Referral occurred at any stage of the patients ' EECU admission .", "output": [ "not found" ] }, { "id": "task180-6b1c9a676df14f369540efe4399a2fcf", "input": "However OC use among nonsmoking women is associated with greater cardiovascular reactivity to stress .", "output": [ "not found" ] }, { "id": "task180-6bac754ad99a43b4990af530f01536b1", "input": "Patients with a score at or beyond this threshold would be considered at high risk for developing NC in later cycles .", "output": [ "not found" ] }, { "id": "task180-1277bb98b1d14547b4eb61624f795fe5", "input": "Our data suggest that mild regular physical exercise favourably influences cholesterol distribution in serum lipoproteins in healthy middle aged men and may have beneficial effects on circulating metabolites of arachidonic acid .", "output": [ "physical exercise" ] }, { "id": "task180-a3495be8f9484b4595872c1068857e60", "input": "Weights and heights were measured at the tri-monthly treatment visits for a period of one year .", "output": [ "not found" ] }, { "id": "task180-a0928e7ca1be4ca0a8a3878d3a6a3236", "input": "Lack of blinding as a result of different treatment schedules may have confounded results .", "output": [ "not found" ] }, { "id": "task180-d8a00b37b7754cb3a41942908d60b6a2", "input": "A physician intervention served the dual function of 1 ) providing an educational demonstration of anxiety in the primary care setting and 2 ) providing a reporting system for summarizing the anxiety symptom levels and functioning status of the patients enrolled in the study .", "output": [ "physician intervention" ] }, { "id": "task180-62b08038ad1947f9994e46aeb65ea0e3", "input": "A randomised trial with concealed allocation , assessor blinding and intention-to-treat analysis was undertaken in an EECU .", "output": [ "not found" ] }, { "id": "task180-4c0abafd196147d6870b89499a3dc699", "input": "Another clinical assessment was done 3 months after the first followup .", "output": [ "not found" ] }, { "id": "task180-fb8417ef202347bc9831812c36498eaf", "input": "Their average age was 45 years , 91 % were male , 58 % were white , 40 % served in Iraq or Afghanistan , and 42 % served in Vietnam .", "output": [ "not found" ] }, { "id": "task180-50e3f687e41545519a91c341fed0535e", "input": "A comparison of different antipyretics in children with malaria showed a small effect of naproxen , but not of metamizol , on the reduction of fever peaks .", "output": [ "naproxen, metamizol" ] }, { "id": "task180-b6ef9996218e459da1a24d391776a593", "input": "Both groups received 24 months of 1,200 mg of calcium and 400 IU of vitamin D daily and 35 mg of risedronate weekly , and the exercise group additionally had ST exercises twice weekly .", "output": [ "calcium, vitamin D, risedronate" ] }, { "id": "task180-c30f1e6f9fb64f66a3b8fce1fb726c41", "input": "Daily supplementation significantly increased plasma concentrations of alpha-tocopherol and beta-carotene in the supplemented group ( Delta 14.4 ( SE 3.2 ) and 0.4 ( se 0.1 ) micromol/l ; P < 0.001 and P < 0.01 ) .", "output": [ "not found" ] }, { "id": "task180-b2d46ae7845844f08a2da9293b23b3b3", "input": "We performed a prospective randomized trial to evaluate the optimum duration of stenting after endopyelotomy .", "output": [ "not found" ] }, { "id": "task180-5cc6c5379d524bb8b639e824aba51691", "input": "A new immunomodulating agent , bestatin ( INN : Ubenimex has low toxicity even after long-term oral administration and has significant modifications in immunological response .", "output": [ "bestatin" ] }, { "id": "task180-595d315322fe41c3a6909d6914942fcc", "input": "We expect the patients in the active recommendations group to experience a greater improvement in their depressive symptoms .", "output": [ "not found" ] }, { "id": "task180-13cf04dcaa7f452890b0c597df9f66bd", "input": "Patients were scanned twice , under either an acute dose of Fluoxetine or placebo in a double-blind , placebo-controlled randomized design .", "output": [ "Fluoxetine, placebo" ] }, { "id": "task180-2be688637f8540fea1c8c359c07ef19b", "input": "We discuss the theoretical relevance of these findings and educational implications .", "output": [ "not found" ] }, { "id": "task180-ef7fe0b70e8642819dfa11fcc117474c", "input": "The patients were followed for change in outcome measures during the five-month study period .", "output": [ "not found" ] }, { "id": "task180-42e448739a9a44088f7b2fbec712e9e1", "input": "Toxicities , including thromboembolism , and overall survival were similar .", "output": [ "not found" ] }, { "id": "task180-c330d95293a64078969a6c4c51946f2b", "input": "Non-inferiority was defined as an upper 95 % confidence limit ( CL ) for the difference in success of eradication in the amoxicillin and penicillin V treatment groups of < or=10 % .", "output": [ "amoxicillin, penicillin" ] }, { "id": "task180-4d0dcdcb1ca64a589a9c632778e501ad", "input": "In conclusion , in 60-year-old subjects antioxidant supplementation had no effect on the exercise-induced increase in oxidative stress as measured by free radical products of antipyrine .", "output": [ "antioxidant supplementation" ] }, { "id": "task180-046c3dbd0c8c433e8cf509426414c8de", "input": "In people with diabetes , renal disease tends to progress from microalbuminuria to clinical proteinuria to renal insufficiency .", "output": [ "not found" ] }, { "id": "task180-41a9145335e24cd880265502f15c3601", "input": "Oral contraceptive use is associated with increased cardiovascular reactivity in nonsmokers .", "output": [ "not found" ] }, { "id": "task180-65a6b4528de443b2bb28e7a523ed1f49", "input": "All participants received usual care .", "output": [ "not found" ] }, { "id": "task180-bcecc8d90cea48ce99ff03f5c15e2f4b", "input": "Follow-up data suggested that treatment gains were maintained by children at 5-months post-intervention .", "output": [ "not found" ] }, { "id": "task180-05f816f72f634d93b63f038e7c30468a", "input": "We evaluated the early clinical and urodynamic results of posterior tibial nerve stimulation in patients with refractory monosymptomatic nocturnal enuresis .", "output": [ "not found" ] }, { "id": "task180-feff536985fe4ff3ac647668a85879ef", "input": "Serotonin is involved in both disorders , and selective serotonin reuptake inhibitors ( SSRIs ) can modulate cognitive flexibility and improve behavior in both disorders .", "output": [ "not found" ] }, { "id": "task180-c153f6e28b304c1186321ccdace7a221", "input": "Repeated-measures analyses within patients assessed drug effects .", "output": [ "not found" ] }, { "id": "task180-7cca98283c494ec4826004b7d1815f2b", "input": "No significant differences in resolution of symptoms were noted between treatment groups .", "output": [ "not found" ] }, { "id": "task180-514bc8035a824c74be3f6e122912e5f3", "input": "Little evidence has been published for the nondiabetic population .", "output": [ "not found" ] }, { "id": "task180-aaae0e0235114c73995b32b757717d1d", "input": "This study reports results of a randomized controlled trial aimed at joint attention ( JA ) and symbolic play ( SP ) in preschool children with autism , with prediction to language outcome 12 months later .", "output": [ "joint attention, symbolic play" ] }, { "id": "task180-cb2ad3914f23486aa1fa9a459e8ca890", "input": "The use of this model may enhance patient care by targeting preventative therapies ( eg , granulocyte colony stimulating factor or PLD ) to those MBC patients most likely to experience NC during anthracycline-based chemotherapy .", "output": [ "not found" ] }, { "id": "task180-6be8016373e747d381ccf3dc15373d2e", "input": "Patients could not have visceral crisis .", "output": [ "not found" ] }, { "id": "task180-6e6a8fb1cff346799e78076232631b80", "input": "The corresponding incidence during the next 21 h ( 3-24 h ) after anaesthesia was 87 % and 62 % ( P = 0.007 ) .", "output": [ "not found" ] }, { "id": "task180-44ed5e96d06642e399e4f0f996084b79", "input": "After adjusting for child demographic characteristics and non-ASD-associated illnesses , ASD was associated with $ 3020 ( 95 % confidence interval [ CI ] : $ 1017- $ 4259 ) higher health care costs and $ 14,061 ( 95 % CI : $ 4390- $ 24,302 ) higher aggregate non-health care costs , including $ 8610 ( 95 % CI : $ 6595- $ 10,421 ) higher school costs .", "output": [ "not found" ] }, { "id": "task180-8edef8cc82e74367951052c0bfd6d0d1", "input": "In adjusted analyses , parents who reported that their child had ASD did not have significantly higher out-of-pocket costs or spend more time on caregiving activities compared with control parents .", "output": [ "not found" ] }, { "id": "task180-32395a2face14e9badb23fa11fbdb8bb", "input": "Also , the average number of wet nights in group 1 was significantly lower than at baseline ( p = 0.002 ) .", "output": [ "not found" ] }, { "id": "task180-ccc12af3b2b24ebbb32ca3ee39a445e1", "input": "Flosequinan evoked a significant increase in maximal exercise capacity .", "output": [ "not found" ] }, { "id": "task180-6c96af5cc6834da89e68024373f5a2a3", "input": "Evaluation was performed in each group at baseline and after posterior tibial nerve stimulation to compare clinical and urodynamic findings .", "output": [ "not found" ] }, { "id": "task180-d4beb727d4bb49c6afa9bd3c3704e4c6", "input": "The 2 groups were comparable in baseline clinical and urodynamic data .", "output": [ "not found" ] }, { "id": "task180-3174575399a4465f8b338844a7c8af8c", "input": "After one week of baseline assessment , patients were randomised into one of the two arms of the study .", "output": [ "not found" ] }, { "id": "task180-9fb3094dd52f45d0b921db3db726adab", "input": "We performed a randomized , controlled study comparing the prophylactic effects of capsule forms of fluconazole ( n = 110 ) and itraconazole ( n = 108 ) in patients with acute myeloid leukemia ( AML ) or myelodysplastic syndromes ( MDS ) during and after chemotherapy .", "output": [ "fluconazole, itraconazole" ] }, { "id": "task180-6b3ab080b30b4b7cbb5af3965de6b9f5", "input": "One week after recommendations were delivered , only patients in the experimental group had increased time of sun exposure and physical activity ( 25.8 % and 14.3 % , respectively ) .", "output": [ "sun exposure, physical activity" ] }, { "id": "task180-be8fb7b532134bc68a770114b8e03a85", "input": "Risk factors retained in the model included poor performance status , absolute neutrophil count < or =2.0 x 10 ( 9 ) cells/L in the previous cycle , the first cycle of chemotherapy , DOX versus PLD and advanced age .", "output": [ "not found" ] }, { "id": "task180-e857e643ebed486f93961ee4b3103ae6", "input": "This study aimed to investigate the course of depression for patients with recently diagnosed rheumatoid arthritis ( RA ) and to investigate predictors of depression .", "output": [ "not found" ] }, { "id": "task180-15d33f2ca0ef4bd696492c7237582f5a", "input": "The economic burden associated with ASD is substantial and can be measured across multiple sectors of our society .", "output": [ "not found" ] }, { "id": "task180-1806524b22a242a29495ec96fd275bd1", "input": "In patients with MDS or in the remission-induction phase of chemotherapy , the numbers of cases with probable or possible infections were lower in the itraconazole group than in the fluconazole group , whereas no difference was seen in patients with AML or in the consolidation phase of therapy .", "output": [ "itraconazole, fluconazole" ] }, { "id": "task180-e3fceed402b94a2d99e0ebf00fe61a9f", "input": "NC were defined as an absolute neutrophil count < or =1.5 x 10 ( 9 ) cells/L ( ie , > or =grade II ) before the next cycle , febrile neutropenia or neutropenia with a documented infection .", "output": [ "not found" ] }, { "id": "task180-33157d402e464526a1234f6b7df442ec", "input": "However , there was an inverse relation between time-varying abstinence ( vs. smoking ) and concurrent level of depressive symptoms , indicating that transitions from smoking to abstinence within individuals were associated with reductions in depressive symptoms .", "output": [ "not found" ] }, { "id": "task180-13db2e2fe08b4f4abfe08bbf6b405522", "input": "Strength/weight training exercises may prevent loss of BMD in postmenopausal BCS at risk for bone loss .", "output": [ "not found" ] }, { "id": "task180-d5cf708933f949378c67d14b3b3082fa", "input": "At the end of 1 year 24 group 1 ( 92.3 % ) and 23 group 2 ( 90.3 % ) patients had an improved drainage pattern .", "output": [ "not found" ] }, { "id": "task180-58756d9e6c0a49ba85ba6728744a6536", "input": "A 3 day balance was performed at the end of each period , and fasting blood samples were collected .", "output": [ "not found" ] }, { "id": "task180-e12bf1a1d6664beb95428afb9bf3c28e", "input": "Influence of lime juice on the severity of sickle cell anemia .", "output": [ "lime juice" ] }, { "id": "task180-592b1b89b7f34cad8b4d201199dea67b", "input": "In COPD patients , reversibility is currently evaluated from the changes of forced expiratory volume at 1s ( \u0394FEV1 ) and forced vital capacity ( \u0394FVC ) .", "output": [ "not found" ] }, { "id": "task180-43391b0017fc452fa5b2f524f6593a3c", "input": "No statistically significant differences in myocardial perfusion measured were found with xenon-133 in this small group between rest and dipyridamole load for ionic and non-ionic contrast media .", "output": [ "not found" ] }, { "id": "task180-75135aa155cd4cf9b9e97a2a7e730ad5", "input": "After the 6-month training period , the SST Group made fewer errors in labeling anger on adult faces , whereas error rates in the LA Group remained stable .", "output": [ "SST, LA" ] }, { "id": "task180-94795eac6afb40a68017a03eae53c348", "input": "Social skills improvement in children with high-functioning autism : a pilot randomized controlled trial .", "output": [ "not found" ] }, { "id": "task180-8dbb891554c1458ebfc50d00f93c8769", "input": "21 patients ( age 0-2 months ) and 40 healthy infants ( age 0-2 months ) were investigated .", "output": [ "not found" ] }, { "id": "task180-8393b303a78a42e6a0a5aec4fe5b2b82", "input": "Youth with autism spectrum disorder comprehend lexicalized and novel primary conceptual metaphors .", "output": [ "not found" ] }, { "id": "task180-65fbdd0fec8e4b49be6595fe0d1d55c1", "input": "Subjects who were > or =50 % adherent to exercise had no improvement in BMD but were less likely to lose BMD .", "output": [ "not found" ] }, { "id": "task180-dc635872f9b64954894b74ee1637836a", "input": "Significant differences in terms of \u0394ITGV ( p=0.002 ) , \u0394RV ( p=0.023 ) , and \u0394VAS ( p < 0.001 ) occurred only if patients were stratified according to \u0394sRAW .", "output": [ "not found" ] }, { "id": "task180-78960c1bccc645d9a4390b532ab8195f", "input": "Spirographic and \u0394sRAW-based criteria identified as responders 24 and 45 patients , respectively .", "output": [ "not found" ] }, { "id": "task180-167a4610170b4e9aab6454427a8f03d3", "input": "The patients were examined in the acute state and after treatment when possible .", "output": [ "not found" ] }, { "id": "task180-d176f1f92b6d4be5a1ab53c8f0f6792d", "input": "Eighty depressed patients undergoing standard antidepressant treatment will be advised to follow four additional hygienic-dietary recommendations about exercise , diet , sunlight exposure and sleep .", "output": [ "hygienic-dietary" ] }, { "id": "task180-bcecc476ae4b458987206c6504a9d698", "input": "This study retrospectively analyzed changes of proteinuria over 4.5 yr in the HOPE ( Heart Outcomes and Prevention Evaluation ) study , which compared ramipril 's effects to placebo in 9297 participants , including 3577 with diabetes and 1956 with microalbuminuria .", "output": [ "ramipril" ] }, { "id": "task180-9ce342dc18a64499b6750513f8783c2b", "input": "Assessment instructions included the Chinese State-Trait Anxiety Inventory ( C-STAI ) , the Quality of Life Index for Colostomy ( QoL-Colostomy ) and the Hong Kong Chinese version of the World Health Organisation Quality of Life Scale ( WHOQoL ) .", "output": [ "not found" ] }, { "id": "task180-f6c3fd7756f84be7bc1f5788cf7e22a9", "input": "Inverse Effect of Fluoxetine on Medial Prefrontal Cortex Activation During Reward Reversal in ADHD and Autism .", "output": [ "Fluoxetine" ] }, { "id": "task180-2fd1583c8d1844608ae9b4dfbc3c95e2", "input": "Teacher-report data also confirmed that children receiving the intervention made significant improvements in social functioning from pre- to post-treatment .", "output": [ "not found" ] }, { "id": "task180-9c2f4c8c798e4fe98a9fc981101bc585", "input": "Studies in animals show good healing after 1 to 2 weeks of ureterotomy .", "output": [ "not found" ] }, { "id": "task180-506187a48e8c4872a0f2481db60e87c5", "input": "Results indicate that expressive language gains were greater for both treatment groups compared with the control group , and results could not be explained by differences in other interventions in which children participated .", "output": [ "not found" ] }, { "id": "task180-dc86b1f0ccbd4d2a97758912a231925a", "input": "Mean change of quantitative muscle strength testing sum scores was the primary study outcome measure .", "output": [ "not found" ] }, { "id": "task180-a592599e77df490eae2bb44f889a2d86", "input": "Children were randomized to a JA intervention , an SP intervention , or control group .", "output": [ "JA, SP, control" ] }, { "id": "task180-95e885275e5c4bdf932ac755f54c35a1", "input": "Extant research has primarily modeled between-person covariation between postquit abstinence and depressive symptom trajectories .", "output": [ "not found" ] }, { "id": "task180-6d8fb1b589cc4f3a8fef7911e18d14ee", "input": "Is a 2-week duration sufficient for stenting in endopyelotomy ?", "output": [ "not found" ] }, { "id": "task180-e916e4da6b15428ba58980b64e537221", "input": "The patients suffered from partial or total intestinal obstruction , necrotizing enterocolitis or pyloric stenosis.All infants were fasting and studied during periods of at least one hour .", "output": [ "not found" ] }, { "id": "task180-64ea23d3ef724d90864e3ef7c0b93463", "input": "Amonafide was given at 300 mg/m2/day i.v . for 5 days , and repeated at 21-day intervals for a maximum of four cycles .", "output": [ "not found" ] }, { "id": "task180-12c7379d2feb46aa8f39ea7469881f56", "input": "Serum lactate levels were significantly high in 500 mg l\u207b\u00b9 group compared to control group .", "output": [ "not found" ] }, { "id": "task180-e06db12f0e034c2687d0c77345992d13", "input": "There may be a steep dose-response curve , based on the significant correlation between myelosuppression and response .", "output": [ "not found" ] }, { "id": "task180-905372c7826b4dd7a238b9c9acce06c8", "input": "The physiotherapy group had a 4 % ( 95 % CI -18 % to 9 % ) lower rate of admission to hospital than the control group and a 4 % ( 95 % CI -6 % to 13 % ) higher rate of re-presentation to the ED , which were statistically non-significant ( p\u22650.45 ) .", "output": [ "physiotherapy, control" ] }, { "id": "task180-b1487ae64ce847419447f9fb406359f6", "input": "The physiotherapy group also received physiotherapy assessment/intervention .", "output": [ "not found" ] }, { "id": "task180-8a66f88154ca48d28bb90c23348e5594", "input": "Its toxicity has previously been correlated to the formation of an active metabolite , N-acetyl-amonafide .", "output": [ "not found" ] }, { "id": "task180-af7a9502cac847c0856e57af651578c0", "input": "Participants were 195 Veterans .", "output": [ "not found" ] }, { "id": "task180-5c9b0478b5f14788a9cd79f8e426a301", "input": "To test the non-inferiority of once-daily ( QD ) oral amoxicillin to the recommended twice-daily ( BID ) oral penicillin V in GABHS pharyngitis .", "output": [ "amoxicillin, penicillin V" ] }, { "id": "task180-17c8151be23b4496a2cdb79312330e23", "input": "A total of 57 consecutive patients with primary ureteropelvic junction obstruction were randomized to undergo 7/14Fr internal endopyelotomy stent placement for 2 ( group 1 ) and 4 ( group 2 ) weeks .", "output": [ "not found" ] }, { "id": "task180-cb81397be54c49de9d593e425920c9ed", "input": "Limitations and suggestions for future research are discussed .", "output": [ "not found" ] }, { "id": "task180-19d1fdec109143efb66aab6182a68716", "input": "Lactate levels were not significantly differed between control , 3,000 , and 700 mg l\u207b\u00b9 groups .", "output": [ "not found" ] }, { "id": "task180-5bf211ab444a4f27953a43b43ec2b00d", "input": "Three hundred forty-one Tanzanian preschool children were randomly assigned to levamisole or placebo treatment given at three-month intervals .", "output": [ "levamisole, placebo" ] }, { "id": "task180-6af604957c664c2eac84ff076c618bd7", "input": "The study was a two-arm , parallel randomized clinical trial .", "output": [ "not found" ] }, { "id": "task180-24520e8ff7e9452a85c77f82dff5de6b", "input": "Participants assigned to 3CM were more likely to have a mental health visit , fill an antidepressant prescription , and have adequate antidepressant refills .", "output": [ "3CM" ] }, { "id": "task180-ed6a5fe743714e818030034969da60b3", "input": "Seventeen patients on chronic digitalis and diuretic therapy were randomized to receive either flosequinan ( n = 9 ) or placebo ( n = 8 ) in a double-blind fashion .", "output": [ "flosequinan, placebo" ] }, { "id": "task180-0d7f0a6dd5e243d69f4bd27115d4f5bf", "input": "Chronic vasodilator therapy with flosequinan in congestive heart failure .", "output": [ "flosequinan" ] }, { "id": "task180-a40f52c1b8374f0d882d63932aff829a", "input": "PTSD patients were recruited from five primary care clinics at four Veterans Affairs healthcare facilities and randomized to receive usual care or usual care plus 3CM .", "output": [ "usual care, usual care plus 3CM" ] }, { "id": "task180-63c0818b5c4c4e3ba358f977cc8d54c1", "input": "A standard general anaesthetic technique was employed throughout .", "output": [ "not found" ] }, { "id": "task180-4bc16316ff6c4d76980d83942a068273", "input": "On two days , 60 COPD patients underwent dyspnea evaluation ( VAS score ) and pulmonary function testing at baseline and one hour after placebo or 300\u03bcg indacaterol administration .", "output": [ "placebo, indacaterol" ] }, { "id": "task180-5d19cc34c7fa4d6aacea7190a1de26b6", "input": "Amonafide is a new imide derivative of naphthalic acid .", "output": [ "not found" ] }, { "id": "task180-99536a6447f5409cbca081acc579ea8e", "input": "Regular intake of lime juice may be of great therapeutic and nutritional relevance in children with SCA .", "output": [ "lime juice" ] }, { "id": "task180-fcbecdc3c7c24ed8b7bda4351fff9347", "input": "Constant exhalation may therefore be a useful alternative to the breath holding technique for clinical measurement of TLCO .", "output": [ "not found" ] }, { "id": "task180-83ffc36c4d9a42e5a2a96c5edb6652ec", "input": "Both patient groups shared decreased precuneus activation .", "output": [ "not found" ] }, { "id": "task180-d3510a1a80254f3cbbcf4a4722e174da", "input": "Economic evaluation of aquatic exercise for persons with osteoarthritis .", "output": [ "aquatic exercise" ] }, { "id": "task180-d817e17714574a5bbd4d2a2495464daf", "input": "Patients did not practise the exhalation manoeuvre prior to testing .", "output": [ "not found" ] }, { "id": "task180-3ae7d37bcf4b4094b82759f2df1be480", "input": "Serum creatine kinase activity decreased significantly in the methotrexate group .", "output": [ "methotrexate" ] }, { "id": "task180-92b2400a98b14662821633bdaf0dbaed", "input": "This study examined whether 24 months of weight training exercises enhanced the effectiveness of risedronate , calcium , and vitamin D in maintaining or improving bone mineral density ( BMD ) in 223 postmenopausal breast cancer survivors .", "output": [ "risedronate, calcium, vitamin D" ] }, { "id": "task180-17012212d17c491cb6085ce4cc084811", "input": "To compare the effect of a Social Skills Training Group-based Program ( SST-GP ) and a Leisure Activities Group-based Program ( LA-GP ) on the perception of facial emotions and quality of life ( QoL ) in young people with HFA .", "output": [ "Social Skills Training Group-based Program, SST-GP, Activities Group-based Program, LA-GP" ] }, { "id": "task180-90e9bff4b5ae4503ac52fcd18dbe799d", "input": "To investigate whether a physiotherapy service to an EECU altered the rate of hospital admission , rate of re-presentation to the ED , visits to community healthcare practitioners , return to usual work/home/leisure activities and patient satisfaction .", "output": [ "physiotherapy" ] }, { "id": "task180-d13f2a404e3e4536bed9e8448a7ef7d6", "input": "Depressive symptoms and biochemically verified abstinence were assessed 1 week prior to and 2 , 8 , 16 , and 26 weeks after quit date .", "output": [ "not found" ] }, { "id": "task180-e8bbb9e0e9e84fc288b28caf017b1f13", "input": "Results suggest the need for careful examination of the way that collaborative care models are implemented for treating PTSD , and for additional supports to encourage primary care providers to manage PTSD .", "output": [ "not found" ] }, { "id": "task180-2dd8be8e50464c3fa585a014526d8698", "input": "Antipyrine was used as marker for oxidative stress .", "output": [ "not found" ] }, { "id": "task180-76348748930c4d0b86eead58f898add2", "input": "Quantitative muscle strength testing sum scores declined in both treatment groups , -0.2 % for methotrexate and -3.4 % for placebo ( 95 % confidence interval = -2.5 % to +9.1 % for difference ) .", "output": [ "methotrexate, placebo" ] }, { "id": "task180-1352e52f6b434be78f700512bb66fb7a", "input": "Antipyretic treatment had no effect on fever clearance and therefore should be used cautiously in the treatment of malaria .", "output": [ "not found" ] }, { "id": "task180-0a0fd3910fb2410093871bb794d7d955", "input": "To estimate cost and outcomes of the Arthritis Foundation aquatic exercise classes from the societal perspective .", "output": [ "aquatic exercise" ] }, { "id": "task180-7b16691c5359466fa2f8ca432bf583ad", "input": "These findings suggest clinically significant benefits of actively treating JA and SP skills in young children with autism .", "output": [ "not found" ] }, { "id": "task180-065186752fca44aba1f1602d02f1e850", "input": "Development of renal disease in people at high cardiovascular risk : results of the HOPE randomized study .", "output": [ "not found" ] }, { "id": "task180-8c04719b3be042e89d8659135f0c09ad", "input": "Thus , this study investigates shared and disorder-specific brain dysfunctions in these 2 disorders during reward reversal , and the acute effects of an SSRI on these .", "output": [ "SSRI" ] }, { "id": "task180-f068f1bd90e743af8c839704b02c2837", "input": "These were initial level of depression , disability , pain , beliefs about the consequences of arthritis and coping strategies .", "output": [ "not found" ] }, { "id": "task180-d2d87b2f64c04233aa4c9dd529903180", "input": "Patients in the experimental group received a brief note in which they were explicitly asked to increase both their physical activity level and time of sun exposure , while control group patients did not receive these explicit recommendations .", "output": [ "physical activity, sun exposure" ] }, { "id": "task180-99f26cfd14e54572be2a4e9e15996127", "input": "At present no study of gastric dysrhythmia , measured with epigastric impedance , has been presented , and the purpose of the present study was to investigate gastric rhythms by means of impedance gastrography in control infants , compared to infants with different gastrointestinal diseases , before and after treatment of their disease .", "output": [ "not found" ] }, { "id": "task180-28c6610ec3c04368b1e754528f73bb1a", "input": "The effects of 12 weeks of antioxidant supplementation on exercise-induced oxidative stress were investigated in older adults ( 60 ( SE 1 ) years ; BMI 26 ( SE 1 ) kg/m ( 2 ) ) .", "output": [ "antioxidant supplementation" ] }, { "id": "task180-57efed2ef50742c6af355ec81ee59cd3", "input": "The results confirm the importance of psychological factors in early RA and their relative independence from physical findings .", "output": [ "not found" ] }, { "id": "task180-e3c37f3d9f1d4f2f8af3233a11c8e889", "input": "Recruited 249 adults from Washington State aged 55 to 75 with a doctor-confirmed diagnosis of osteoarthritis to participate in aquatic classes .", "output": [ "aquatic classes" ] }, { "id": "task180-d832ce7078f84ad9a85385f98dbfc9d6", "input": "The sample comprised 186 patients ( mean age 70 years , 123 ( 66 % ) female patients , 130 ( 70 % ) trauma ) who were referred for physiotherapy assessment/intervention .", "output": [ "not found" ] }, { "id": "task180-71467834f719423fa45b44a9165f7d02", "input": "The trial design is compared to a trial without adaptive randomization and produces an efficient trial in which a higher proportion of patients are likely to be randomized to the most effective treatment arm while generally using fewer total patients and offers higher power than an analogous trial with fixed randomization when identifying a superior treatment .", "output": [ "not found" ] }, { "id": "task180-60770b8b656847cdabcb85b33fd2e510", "input": "Data justify replication using larger samples .", "output": [ "not found" ] }, { "id": "task180-4b79d7d51f19485a8c89aa9ed42b4f47", "input": "Postmenopausal BCS ( 223 ) were randomly assigned to exercise plus medication or medication only groups .", "output": [ "exercise plus medication, medication" ] }, { "id": "task180-1e78b5a993ad4aa2a8773bc46c4650df", "input": "Effects of mild physical exercise on serum lipoproteins and metabolites of arachidonic acid : a controlled randomised trial in middle aged men .", "output": [ "physical exercise" ] }, { "id": "task180-4486d80450594206980a09c7a0a08a82", "input": "Attention deficit hyperactivity disorder ( ADHD ) and autism spectrum disorder ( ASD ) share brain function abnormalities during cognitive flexibility .", "output": [ "not found" ] }, { "id": "task180-5bcffc040613482ead1af1c93c11f321", "input": "\u0394sRAW correlated with changes of intrathoracic gas volume ( \u0394ITGV ) ( r=0.61 ; p < 0.001 ) , residual volume ( \u0394RV ) ( r=0.60 ; p < 0.001 ) , \u0394FVC ( r=0.44 ; p=0.001 ) , and \u0394VAS ( r=0.73 ; p < 0.001 ) , while \u0394FEV1 correlated only with \u0394FVC ( r=0.34 ; p=0.008 ) .", "output": [ "not found" ] }, { "id": "task180-3c5cfa81818d4e6fb2844f77468029c6", "input": "All participants received medical/nursing care as required .", "output": [ "not found" ] }, { "id": "task180-a2d8986a98634f1e84dffb0f16cca37b", "input": "The in vitro assay showed similar solubility after the in vitro digestion and similar transport across Caco-2 cells .", "output": [ "not found" ] }, { "id": "task180-3d3d47d541734fd7a66065008db40669", "input": "Additional changes in BMD and bone turnover with exercise were not significant .", "output": [ "not found" ] }, { "id": "task180-7cfe79e8add146de8e73573a4d5336c6", "input": "Although collaborative care is effective for treating depression and other mental disorders in primary care , there have been no randomized trials of collaborative care specifically for patients with Posttraumatic stress disorder ( PTSD ) .", "output": [ "collaborative care" ] }, { "id": "task180-b6056ef84e9c4ccf9b2fb12e9931cb25", "input": "Amonafide : An active agent in the treatment of previously untreated advanced breast cancer -- a cancer and leukemia group B study ( CALGB 8642 ) .", "output": [ "not found" ] }, { "id": "task180-91c82fa5cc764eaa87e8138bc93650b0", "input": "Treatment with lime did not cause any significant side-effect .", "output": [ "lime" ] }, { "id": "task180-49d67276cbfe491db5beade0791a8dad", "input": "Although an increasing number of group-based programs for the improvement of social skills have been described , randomized controlled trials are needed to evaluate their efficacy .", "output": [ "not found" ] }, { "id": "task180-b63cffd9dab643d8800a67389f289ab1", "input": "Twenty-two patients with a history of recently diagnosed RA of less than 2 years were assessed on a variety of clinical outcome and process measures on six assessment occasions over a 21-month period .", "output": [ "not found" ] }, { "id": "task180-651f2cffb73e4b72ae66f15951fc7937", "input": "As calcium acquired during adolescence is essential to maximize peak bone mass and to prevent osteoporosis , possible long-term effects of excessive MRP intake during this period warrant attention .", "output": [ "not found" ] }, { "id": "task180-fa4eb06f151e44f4a73988a6f48c2e61", "input": "The 2 groups were comparable in terms of age , sex , symptoms and ipsilateral glomerular filtration rate .", "output": [ "not found" ] }, { "id": "task180-0771cc9ec5a640859cd672476b478d78", "input": "The Quality of Well-Being Scale ( QWB ) and Current Health Desirability Rating ( CHDR ) were used for economic evaluation , supplemented by the arthritis-specific Health Assessment Questionnaire ( HAQ ) , Center for Epidemiologic Studies-Depression Scale ( CES-D ) , and Perceived Quality of Life Scale ( PQOL ) collected at baseline and postclass .", "output": [ "not found" ] }, { "id": "task180-e4e423ca174e4b61b9e002b4f48aa140", "input": "Patients in the 40K arm had a higher global quality of life ( QOL ) at baseline for unclear reasons , whereas patients in the 120K arm had a greater global QOL improvement during the study , so end-of-study QOL was equivalent .", "output": [ "not found" ] }, { "id": "task180-14239d6bfd574a2a8b1df01ea319604a", "input": "Though this prolongation of remission was not significant in the bestatin group compared to the control group in the 15-49 yr age group , in the 50-65 yr age group it was significantly longer .", "output": [ "bestatin, control" ] }, { "id": "task180-aec9bb8a631c4718ac7425bdb0f2fbb2", "input": "Efforts to promote smoking cessation should highlight that individuals are likely to feel more rather than less psychologically healthy when they successfully quit smoking .", "output": [ "not found" ] }, { "id": "task180-eda45c06e10241d19055ac958f251c0c", "input": "A cooperative randomized controlled study of bestatin immunotherapy in combination with remission maintenance chemotherapy for adult acute nonlymphocytic leukemia ( ANLL ) was performed .", "output": [ "bestatin" ] }, { "id": "task180-f2088b019d7140408119229577c83a34", "input": "In recent years some studies have been published supporting the efficacy of light exposure , physical activity , sleep control and a Mediterranean diet pattern on the improvement or prevention of depression .", "output": [ "light exposure, physical activity, sleep control, Mediterranean diet" ] }, { "id": "task180-52462692209e45309c93224935520e33", "input": "When one treatment is superior to the other two , the trial design provides better patient care , higher power , and a lower expected sample size .", "output": [ "not found" ] }, { "id": "task180-cebbd69afbcf4316a7983c00d5f33a11", "input": "The course of depression in recent onset rheumatoid arthritis : the predictive role of disability , illness perceptions , pain and coping .", "output": [ "not found" ] }, { "id": "task180-6901852277a5417bb4762d07620180d8", "input": "The origin of the gastric phasic activity patterns is unknown , but they may be related to electrical control activity .", "output": [ "not found" ] }, { "id": "task180-73a0a201b86e46da8bf577704e711297", "input": "In contrast , the number of wet nights and urodynamic parameters did not change significantly in group 2 .", "output": [ "not found" ] }, { "id": "task180-22d1afb7c7a340d685cec1f3a4a29cdd", "input": "In addition , supplementation did not affect the exercise-induced increase in thiobarbituric acid reactive substances in plasma .", "output": [ "supplementation" ] }, { "id": "task180-d864663b593f4c41be613858c6c79ffa", "input": "Patient outcomes were measured as changes in global anxiety scores , functioning and well-being , and patients ' reports of global improvements .", "output": [ "not found" ] }, { "id": "task180-ef04dc8607aa4661a472619190a7df69", "input": "Assays in male adolescents and in Caco-2 cells .", "output": [ "not found" ] }, { "id": "task180-bb9e057418fd42cb8c8fb1a35fb7cbdb", "input": "The mean hematocrit of the subjects ( 26.23\u00b12.03 % ) at the end of the study was also higher , p < 0.001 .", "output": [ "not found" ] }, { "id": "task180-acfde020ef074a6784fe72c29182a56b", "input": "Multicenter , randomized , controlled , two arm-parallel , clinical trial .", "output": [ "not found" ] }, { "id": "task180-76fb002622fe43bc97b800c34e80cc31", "input": "We randomly assigned 28 patients with refractory monosymptomatic nocturnal enuresis to 2 equal groups .", "output": [ "not found" ] }, { "id": "task180-2a6ba588a09640a2aeb427d193dd345c", "input": "Using backward elimination , we derived a risk scoring algorithm ( range 0-63 ) from the final reduced model .", "output": [ "not found" ] }, { "id": "task180-5b029590cfc54607a4bb455b8fb936b3", "input": "Patient and hematologic factors potentially associated with NC were evaluated .", "output": [ "not found" ] }, { "id": "task180-0cd5ef2d77e24b4c83a92001d00c2cb7", "input": "We conclude that oral methotrexate did not slow down progression of muscle weakness but decreased serum creatine kinase activity .", "output": [ "methotrexate" ] }, { "id": "task180-de619b1cb2c24e0a84ca3912117739ca", "input": "Blinded assessors collected data at baseline and 3-month and 6-month follow-up .", "output": [ "not found" ] }, { "id": "task180-06661c259f4f47fa86e925c3e8224840", "input": "Data analyzed was from a phase III , randomized clinical trial of DOX ( 60 mg/m ( 2 ) every 3 weeks ) or PLD ( 50 mg/m ( 2 ) every 4 weeks ) for the first line therapy for MBC ( n = 509 ) ( O'Brien et al , Ann Oncol .", "output": [ "DOX, PLD" ] }, { "id": "task180-e40f2ed7287d4c91acb586914319f2cb", "input": "Heart rate , blood pressure , and lipid measures were taken at rest , during a videotaped speech task , and during recovery from the task .", "output": [ "not found" ] }, { "id": "task180-f50cb1ca07dd422bb5beef68acff32e9", "input": "Also , fewer subjects than the controls had significant painful episodes ( 50.0 % versus 92.7 % ) ; febrile illness ( 46.6 % versus 87.3 % ) and admission rate ( 3.4 % versus 34.5 % ) ( p < 0.001 ) .", "output": [ "not found" ] }, { "id": "task180-932eb64a68344a4db37f913221861769", "input": "For children beginning treatment with the lowest language levels , the JA intervention improved language outcome significantly more than did the SP or control interventions .", "output": [ "JA, SP, control" ] }, { "id": "task180-dd54166cce224eb2856fc586c6387a8e", "input": "Results indicated that there was a significant decrease in both the C-STAI score ( F = 4.66 , P < 0.05 ) and the WHOQoL score ( F = 4.74 , P < 0.05 ) in the experimental group .", "output": [ "not found" ] }, { "id": "task180-761fc5af727a4f1f8dd37e98ad6c76d0", "input": "This study examined whether ( 1 ) postmenopausal breast cancer survivors ( BCS ) with bone loss taking 24 months of risedronate , calcium , and vitamin D had increased bone mineral density ( BMD ) at the total hip , femoral neck , L1-L4 spine , total radius and 33 % radius , and decreased bone turnover ; ( 2 ) subjects who also participated in strength/weight training ( ST ) exercises had greater increases in BMD and greater decreases in bone turnover ; and ( 3 ) subjects who also exercised were more likely to preserve ( at least maintain ) BMD .", "output": [ "risedronate, calcium, vitamin D, strength/weight training, ST, exercised" ] }, { "id": "task180-c206529b339c478ca1876eecb130fc44", "input": "A physiotherapy service for EECU patients , as provided in this study , did not reduce the rate of hospital admission , rate of re-presentation to the ED , use of community healthcare resources , or improve the rate of return to usual work/home/leisure activities or patient satisfaction .", "output": [ "not found" ] }, { "id": "task180-a2d8ba1afecd46cdad68c3e8889d5fbf", "input": "The latter metabolite is not formed in man through the mono-oxygenase pathway of cytochrome P450 .", "output": [ "not found" ] }, { "id": "task180-5c3d152e6b884f9fa25332b53f6f6916", "input": "The comparative results were very close ; mean difference ( bias ) +/- standard deviation ( precision ) was 0.05 ( 0.84 ) mmol/min/kPa .", "output": [ "not found" ] }, { "id": "task180-8032d2653f55447085a3a33c8ab4ced0", "input": "Cardiovascular reactivity to psychological stress may be one mechanism for the enhanced risk , but the small number of studies examining whether OC users who smoke have greater reactivity have produced mixed results .", "output": [ "not found" ] }, { "id": "task180-0aa71907fe174373840fb402072b19ac", "input": "The end point of CALGB 8642 is to assess the difference in survival , toxicity , and overall response when limited exposure to Phase II agents precedes standard chemotherapy .", "output": [ "not found" ] }, { "id": "task180-1b9be97084f84b75ab2bf548ef360ade", "input": "We conducted a study including 15 depressive patients who had been under antidepressant treatment for at least one month .", "output": [ "antidepressant" ] }, { "id": "task180-71f61d68b67f4cca82a31b905e7c3627", "input": "Serum biochemical characteristics of Beluga , Huso huso ( L. ) , in response to blood sampling after clove powder solution exposure .", "output": [ "clove powder solution" ] }, { "id": "task180-dc3dabc455df4573a5327c111a8ab45f", "input": "fMRI data showed that , under placebo , ASD boys underactivated medial prefrontal cortex ( mPFC ) , compared with control and ADHD boys .", "output": [ "placebo" ] }, { "id": "task180-3ca613e5046844c6b72fce5e08270b17", "input": "Using epigastric impedance we found that infants with partial or total intestinal obstruction had gastric phasic activity , which was not found in the control infants .", "output": [ "not found" ] }, { "id": "task180-ea2cce048a414b0eb87eb2a36c1430ac", "input": "To study the effects of physical exercise on biochemical risk factors for ischaemic heart disease 31 healthy middle aged men undertook regular physical exercise for two months and 29 served as controls in a randomised trial .", "output": [ "physical exercise" ] } ], "Instance License": [ "Unknown" ] }