{
    "Contributors": [
        "Ishani Mondal"
    ],
    "Source": [
        "ADE Corpus V2"
    ],
    "URL": [
        "https://github.com/trunghlt/AdverseDrugReaction/tree/master/ADE-Corpus-V2"
    ],
    "Categories": [
        "Text Classification"
    ],
    "Reasoning": [],
    "Definition": [
        "Adverse drug reactions are appreciably harmful or unpleasant reactions resulting from an intervention related to the use of medical products, which predicts hazard from future administration and warrants prevention or specific treatment, or alteration of the dosage regimen, or withdrawal of the product. Given medical case reports extracted from MEDLINE, the task is to classify whether the case report mentions the presence of any adverse drug reaction. Classify your answers into non-adverse drug event and adverse drug event."
    ],
    "Input_language": [
        "English"
    ],
    "Output_language": [
        "English"
    ],
    "Instruction_language": [
        "English"
    ],
    "Domains": [
        "Medical Knowledge"
    ],
    "Positive Examples": [
        {
            "input": "A case is reported of a child with fatal pulmonary fibrosis following BCNU therapy.",
            "output": "adverse drug event",
            "explanation": "Here, the child is facing some trouble after undergoing a particular therapy, thereby causing an adverse effect of the therapy."
        },
        {
            "input": "She responded well to Sodium valproate.",
            "output": "non-adverse drug event",
            "explanation": "This is a pretty straightforward remark because it is related to filing taxes with minimal stress and is unrelated to irony or sarcasm."
        }
    ],
    "Negative Examples": [
        {
            "input": "The patient suffered from breathing trouble after taking azithromycin.",
            "output": "serious",
            "explanation": "You are expected to return \"adverse drug event\" or \"non-adverse drug event\". This should be classified as adverse drug event because the patient suffers from an issue after taking in a particular drug."
        },
        {
            "input": "The patient is feeling better at the hospital.",
            "output": "wellness",
            "explanation": "You are expected to return \"adverse drug event\" or \"non-adverse drug event\". This should be classified as non-adverse drug event because no harmful after-effect of any medical intervention has been mentioned."
        },
        {
            "input": "A case is reported of a child with fatal pulmonary fibrosis following BCNU therapy.",
            "output": "non-adverse drug event",
            "explanation": "Here, the child is facing some trouble after undergoing a particular therapy, thereby causing an adverse effect of the therapy. So, it needs to be tagged as adverse drug event instead of non-adverse drug event."
        }
    ],
    "Instances": [
        {
            "id": "task1495-d9c9a5105d4142eca7ab360e0b754122",
            "input": "A 43-year-old white man developed a shallow erosion of a psoriatic plaque after chronic administration of methotrexate.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-aed4b3b85d764af2901994fc35310ed2",
            "input": "Clinicians should be vigilant when monitoring for cardiotoxicity in patients receiving pentamidine throughout the duration of therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f4d88b8190f34c08b4bbffded9eccf63",
            "input": "The dermatology literature heretofore has not noted that anemia is a side effect of patients taking MMF to treat pemphigus.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-7c10349c623f4922af55624b9df053da",
            "input": "Both PAN and methotrexate have been independently demonstrated to cause sensorineural hearing loss.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-21bb42c5253b4d4783e9fa2254729e57",
            "input": "Acute hepatic failure is a rare and potentially lethal complication of propylthiouracil (PTU) use for hyperthyroidism.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-7be62ea03dc0415fa3c3921ded954136",
            "input": "We are concerned that the macular lesion was a retinal toxic effect of gentamicin because of the recent description of similar lesions occurring after the inadvertent intraocular injection of massive doses of this drug.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d2468332c4664bccbe13562b9fae2f07",
            "input": "A case of propranolol overdose complicated by esophageal spasm preventing extrication of an orogastric lavage tube and relieved by intravenous glucagon is presented.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1e306a2634f54297ba3e4c580ae3a9d9",
            "input": "Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5f9dd927f9594ed09c4655052c2959e4",
            "input": "Agranulocytosis and granulocytopenia associated with quetiapine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-de2023bbf92d4eb6bc97a169a8d01dcf",
            "input": "A 51-year-old man developed type 1 diabetes mellitus following 24 weeks of treatment with recombinant alpha-2b peginterferon plus ribavirin for chronic hepatitis C.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1dc37875bf024d94ab0598fbbd334281",
            "input": "Overdose of magnesium sulfate in combination with renal insufficiency, hypocalcemia, or compromise of intestinal integrity may predispose horses to magnesium toxicosis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1d826ac630534077a8590d0c56e58c08",
            "input": "Asthma and urticaria during disodium cromoglycate treatment.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-696bfa6c130344558f8744571c2927a9",
            "input": "Four patients in whom pulmonary oedema developed during tocolysis with hexoprenaline are described and the aetiological factors and pathogenesis of this potentially lethal complication discussed.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b8cf0df1f500476690d29cca914fa1f4",
            "input": "CONCLUSIONS: We report this case of the concomitant appearance of multiple skin cancers and nail changes associated with hydroxyurea use.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-294c9a8d5e654c06bd7b17ddfe280ef2",
            "input": "Pilocarpine toxicity and the treatment of xerostomia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2402cf9fcc1246dbb4486bc190bdf02f",
            "input": "Gemcitabine-induced pulmonary toxicity is usually a dramatic condition.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6560f8261304463ea4e3a34d8f6ccc26",
            "input": "CONCLUSION: Patients with insulin allergy may not have complete resolution of their symptoms after standard desensitization, particularly those patients with concomitant protamine allergy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2f365c0ce7b343a6a81739f5e86a10c6",
            "input": "Two patients who developed decreased visual acuity after several months of ethambutol treatment for Mycobacterium avium-intracellulare infection had bitemporal visual field defects that suggested optic chiasm damage.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2d09b5b797b14f7bbb4fe505028c1475",
            "input": "This case presentation is of a patient who had the clinical appearance of epiglottitis, but actually had an oro-pharyngeal dystonic reaction to prochlorperazine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4bb4924a3c4f4c0fa1950572e0ee0aa5",
            "input": "While for ribavirin antidepressant effects are not known, we suppose that antidepressants may prevent changes in serotonergic or noradrenergic neurotransmission caused by IFN-alpha",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1523c9bfd40041639cfdc94b6eef4366",
            "input": "We describe 2 children with cerebral palsy who suffered significant morbidity immediately after treatment with hyperbaric oxygen.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-65b28e650b6f4c60b18b3f13681c2bb2",
            "input": "A healthy, 30-year-old man, exposed to sulindac on two separate occasions, had an incapacitating isolated idential sensory neuropathy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-552514a3de9049ebb8e5eb0e0e873f8a",
            "input": "In the first patient, two episodes of ventricular tachycardia requiring cardioversion occurred in close temporal sequence with administering bretylium.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-15ce7f5d345c4bafbbd1cc4e3a41dae3",
            "input": "Regardless of a negative history of asthma, therefore, life-threatening bronchospasm must be considered a possible complication of propranolol therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6cad9ef5933b4dafb8831ae92df39dc2",
            "input": "Despite a very low complication rate, several severe arterial thrombotic events have been reported following thrombin injection of pseudoaneurysms.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-8e56f8506adf4d7e91332c3037e32b35",
            "input": "Bone marrow aplasia and severe skin rash after a single low dose of methotrexate.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5e45d3d6a5b54af9b4a96b0c205a6b47",
            "input": "METHOD: The authors followed a patient with chronic HCV who received interferon and ribavirin and who developed hallucinations ultimately requiring psychiatric hospitalization.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-eb6f15b1df2641f7b990877d06d9acaa",
            "input": "Monoclonal gammopathy and subsequent multiple myeloma in a patient on chronic diphenylhydantoin therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3dbe283bd1d5421db669cd7c9ff9db8f",
            "input": "To our knowledge, four cases of interstitial pneumonitis associated with fludarabine have been reported in medical literature.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1fec55194c24410faf7e24b40ccb5134",
            "input": "CONCLUSIONS: The increasing prevalence of Type 2 diabetes and its treatment with metformin might result in more cases of lactic acidosis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5e07735c91a6444ca5fce95e1808201a",
            "input": "CONCLUSIONS: Priapism is an uncommon but potentially serious adverse effect of zuclopenthixol that practitioners, as with many other antipsychotics, should be aware of.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-61d866708d24415fadbfebdf65d956c9",
            "input": "Hepatotoxicity of paracetamol enhanced by ingestion of alcohol: report of two cases.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c4cbd15135a0466ba14802da87c52e0c",
            "input": "We report on a 14-year-old boy with severe haemophilia A who developed a portal vein thrombosis during continuous infusion of F VIII.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-59e6b8644b9b4e0ebe210352db65f13a",
            "input": "We report the case of an 11-year-old female treated for mediastinal T-cell lymphoma who presented renal failure following the second cycle of high-dose methotrexate (HDMTX).",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9ef6e0e484934172a5645a89c42449c2",
            "input": "Attenuation of asparaginase-induced hyperglycemia after substitution of the Erwinia carotovora for the Escherichia coli enzyme preparation.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-8c0e8500646b46cf815dc168324bc50c",
            "input": "The aim of this paper is to report the case of rosaceiform eruption induced by erlotinib in an 81-year-old-man and to discuss the pathogenetic role of Demodex folliculorum mites, found in the present patient, using skin scraping.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-94ba84bf086945adbfd294516229d43a",
            "input": "Clofazimine induced nail changes.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-8f17dd5649c844759ce0a6a92c3ad6ac",
            "input": "Graves' hyperthyroidism following transient thyrotoxicosis during interferon therapy for chronic hepatitis type C.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-eda0494c23af47efba3472571568ab4e",
            "input": "She had just finished a 3-week course of intravenous tobramycin for bronchiectasis and had an elevated serum tobramycin trough level 1 week before the onset of tetany.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a46b155eb86b4fb8be67173c89dd8384",
            "input": "Physicians who use sulfasalazine to treat patients with inflammatory bowel disease should be aware of the signs of sulfasalazine-induced lupus syndrome.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-34a9524633354044868053451876196e",
            "input": "We recommend that clinicians monitor patients for signs and symptoms of pancreatitis, including abdominal pain, during treatment with tigecycline.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-aa1b5fe728d149bf95a1461cee7aad13",
            "input": "Exacerbation of 5-FU dermatologic toxicities in patients with preexisting conditions suggests the importance of aggressive ocular prophylaxis, using frequent ocular lubrication and topical steroid preparations with concurrent medical management of pre-existing dermatologic conditions.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-eb13d24af3a748c2b5b139840da7fba5",
            "input": "The 3-week sulphasalazine syndrome strikes again.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-44ba10fd17454ae19c2826f368649754",
            "input": "She developed a generalized rash and itching, sore throat, and dizziness approximately 4 hours after the first dose of capecitabine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ba7f4b9c80b74399bd8cdcf49c3a8ec8",
            "input": "Chronic hydroxychloroquine use associated with QT prolongation and refractory ventricular arrhythmia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ce5bf89a8e834422b3d8119d8f8a54d7",
            "input": "To our knowledge, these cases are the first published reports of lovastatin-induced rhabdomyolysis associated with azithromycin and clarithromycin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1241a30e1cda4d4085b0cacaf5e0b412",
            "input": "We conjectured that the side effects of insulin, such as anti-natriuresis and increased vascular permeability, might be pronounced in the presence of the hepatic dysfunction that accompanies insulin insensitivity, hyperinsulinaemia and hypoalbuminaemia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c9bfd10512bf4fb1ad6f05473fe7c0cf",
            "input": "We report two cases of cerebrospinal fluid eosinophilia (CSFE) secondary to the intraventricular administration of vancomycin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-297e3086490c46f19fb81c24347ab3fc",
            "input": "Five patients are described in whom only gentamicin sulfate appeared responsible for acute renal failure.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1ab17473c174499cb797e8e490c0bf5b",
            "input": "BACKGROUND: How to best treat psychotic patients who have had past clozapine-induced agranulocytosis or granulocytopenia remains a problem.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-bf58f9c0de4d45a3b6025434f4bc6bdf",
            "input": "Three distinct types of minocycline-induced cutaneous pigmentation have been described.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9302cba7834e4a679aecef0e58181ab7",
            "input": "Four patients receiving high-dose tamoxifen for greater than 1 year have demonstrated similar retinal changes.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e1a06c540b254f6693c9c5399097cc8c",
            "input": "A patient suffering from heparin-associated thrombocytopenia (HAT), recurrent arteriothromboses, and acute renal failure after treatment with standard heparin is described.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-aa25f1192bb541448d02ff57bdb29593",
            "input": "When cyanamide-treated alcoholics relapse into drinking, more severe inflammation develops in the liver.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-73f08572707f4597bb6f6c04cb2b020c",
            "input": "Fatal gemcitabine-induced pulmonary toxicity in metastatic   gallbladder adenocarcinoma.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-aa5c73f87cb44590addff6ef3b4082af",
            "input": "The most commonly recognized toxic effect of ethambutol is optic neuropathy, which generally is considered uncommon and reversible in medical literature.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f6ee1cab6b044cb3bf8c9c62964f9896",
            "input": "In all the patients, pellagra symptoms appeared during isoniazid therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-305c9f78c3ea4be191ef8786e367b23c",
            "input": "Ten days after itraconazole was started, he developed paralytic ileus, neurogenic bladder, mild left ptosis, and absence of deep reflexes, with severe paralysis of the lower extremities and mild weakness of the upper extremities.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a101ba16f91846feb68eb72da1ad1103",
            "input": "Propranolol-related bronchospasm in patients without history of asthma.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-44a538aa0f73455a955365344186be45",
            "input": "We describe two patients in whom painful erosions of their psoriasis developed as the presenting sign of methotrexate toxicity and review the literature, emphasizing the risk factors associated with this manifestation.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-7fad282ddfa74df690373dd756651569",
            "input": "All developed mucocutaneous side effects within 20 weeks of beginning im gold therapy, at a time when RA had improved markedly compared to pretreatment status.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-031a437609d44ea1bb4ecb25d13006e5",
            "input": "CONCLUSIONS: Low dosages of quinacrine used for malaria prophylaxis can be associated with a delayed, severe maculopathy indistinguishable from chloroquine maculopathy in certain patients.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1fc645c2291c4bd68ca062d0b94fd535",
            "input": "BACKGROUND: We describe the ophthalmic features and clinical course of two cases of acute syphilitic posterior placoid chorioretinitis (ASPPC) that developed after intravitreal triamcinolone acetonide (IVTA) injection.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2e1f5cb7c8224c23bfc238efe815537d",
            "input": "Carbamazepine-induced systemic lupus erythematosus.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d78e31cf4b7d48278e3fb6832453b009",
            "input": "Hypoglycemia can be a serious side effect of etanercept in patients already on antidiabetic medications known to cause hypoglycemia, such as sulfonylureas, meglitinides, and insulin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0d7286bc8d2748968486c5f718d97ff3",
            "input": "There is evidence that the angiotensin II receptor antagonist, losartan, increases urate excretion by reducing reabsorption of urate in the renal proximal tubule.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-114bb8113e3a400ca2f1231c8d1033c4",
            "input": "Allergic contact dermatitis from 4-chloro-7-nitrobenzofurazan.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f95e53272eca46e4bed671d34e42b450",
            "input": "While most physicians are aware of heparin-induced thrombocytopenia and skin necrosis, the association of heparin and hyperkalemia is less well recognized.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-31f7b1efa9f54516b2da6320f87eac28",
            "input": "The most common complication of warfarin use is adverse bleeding.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-674d2a058a2f4292b8d18a4c5f5358f2",
            "input": "We report a case of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) secondary to trimethoprim-sulfamethoxazole (TMP-Sx) therapy for presumed community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infection.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-75973acf1f7f4370bcd392ee65a6e79d",
            "input": "Rhabdomyolysis caused by tocolysis with oral ritodrine hydrochloride in a pregnant patient with myotonic dystrophy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-799f68dc157948e6934e766e8539ca81",
            "input": "Comeoscleral perforation after pterygium excision and intraoperative mitomycin C.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-370c48c1dd254b0baa9abb0a2fdc71dd",
            "input": "A wide variety of adverse central nervous system effects have been reported in association with propafenone; dizziness is the most common.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-fe654e03b7234096b77e8d12f1daac8f",
            "input": "We describe two patients with aspergillus arthritis of the knee joint following fludarabine-based non-myeloablative stem cell transplantation.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-8dacb1e78da64384875f2832f3910928",
            "input": "Septic knee arthritis after intra-articular hyaluronate injection.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a9a0c03de89043a5af7d0bfdadd213e2",
            "input": "In this report, a patient who had undergone a renal transplantation as a result of malignant hypertension, and who was on immunosuppressive therapy consisting of cyclosporin, prednisone and azathioprine, developed thrombosis of the central retinal vein 5 years following the transplantation.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d60535376655448aabe29d80178030de",
            "input": "Procainamide-induced incessant supraventricular tachycardia in the Wolff-Parkinson-White syndrome.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-7749fd9e645e419ab3ab2f0599d037d1",
            "input": "Stupor and fast activity on electroencephalography in a child treated with valproate.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f2d9632ea32e434e8606a33bfe9dfcf4",
            "input": "Large cerebral infarction during praziquantel therapy in neurocysticercosis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a9302bf11fba4f71b12554f8e11ec0a2",
            "input": "This was accepted as evidence for propranolol being the cause of this conduction disorder.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-14f6a194a99642b885f133fb9a1dfa7d",
            "input": "The results of the ultrasound examination combined with clinical anamnesis allowed diagnosis of gastric mucosa foveolar hyperplasia due to prolonged PGE1 therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-dfc2312996eb459081a16fe2f91876a2",
            "input": "Mitomycin C (MMC) is an alkylating agent that has been recently associated with the hemolytic-uremic syndrome (HUS).",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-cec2eafe25254d7f8d1fc0be6b7c6244",
            "input": "Sarcoma complicating therapy with cyclophosphamide.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-998be19678da47648d39b87e42097a70",
            "input": "METHODS: Repeated blood samples were drawn in a patient with severe acyclovir overdose who developed coma and nonoliguric renal failure.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-21a7ecb6c80e49a7961dfe91c7392bf8",
            "input": "Gemcitabine is a known risk factor for hemolytic uremic syndrome (HUS), which can often have a rapidly fatal clinical course despite intervention with steroids, plasmapheresis and hemodialysis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-7710210c9496472abfbec242b21a0e4a",
            "input": "OBJECTIVE: To report a case of linear immunoglobulin (Ig) A bullous dermatosis (LABD) induced by gemcitabine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-468e750287ea4c6b8a43baeaf988fa94",
            "input": "In four patients, spasm occurred spontaneous and in one patient after 0.05 mg of ergonovine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-edfb7954f75649b186867a786a3f1eff",
            "input": "Warfarin-associated bleeding generally is considered deleterious; however, in our patient it unmasked an early stage of colon cancer and thus may have saved the patient's life.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0d3429b642624357b6a808a017730137",
            "input": "We report the case histories of identical twin brothers who developed concordant acute lymphoblastic leukemia at the age of 4 years and who later developed leukoencephalopathy and hydrocephalus related to central nervous system prophylaxis by, in the first case intrathecally administered methotrexate and, in the second by intrathecally administered methotrexate and cranial irradiation.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6de4fffdb37044068838b1b23c63242c",
            "input": "A 79-year-old man with ischemic heart disease, chronic atrial fibrillation, chronic renal failure, hypothyroidism, and gout arthritis was hospitalized because of fatigue, myalgia, and leg weakness, shortly after starting treatment with colchicine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-98c9430ba30f4e939c9c8f1a761596d3",
            "input": "We report the successful treatment of heparin-induced thrombocytopenia and subsequent hemorrhagic complications postoperatively in a 2-year-old child with Danaparoid (orgaran).",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f32aeb8218514099ad7f4e7f1747306c",
            "input": "Ticlopidine-induced aplastic anemia: two new case reports, review, and meta-analysis of 55 additional cases.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f831395e5b0942f6965f623bf2426adb",
            "input": "The clinical course suggested that recombinant alpha-2b peginterferon plus ribavirin provoked type 1 diabetes mellitus, therefore, in patients who are candidates for interferon therapy the presence of pancreatic autoantibodies and the fasting plasma glucose level should be investigated before and during treatment.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1884a131e35e4b38863fd37b5d708d2f",
            "input": "We report a case of drug-induced Kaposi's sarcoma (KS) on the sole of the right foot in a 71-year-old man, treated for 6 months with corticosteroid therapy (prednisolone 25 mg/day) for pericardial effusion.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f0ab4378aeeb40cdbea3ca57fdf47e56",
            "input": "A 53 year old Greenlandic male was admitted twice over a period of 4 years with a new complete right bundle branch block after ingestion of 10 g and 4 g of carbamazepine respectively.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b7db0725176e4adf806a9a51fd2654f1",
            "input": "The hyperpigmentation was diffuse scattered, flagellate like and linear streaking which was thought to be mainly related to the skin toxicity of bleomycin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b0a7982975424c0aa488c637bc9f9bd5",
            "input": "Of the four patients who responded to HU with an increase in total Hb, all reported symptomatic improvement and three have not required further transfusions.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-79eb0413d17141379e4fd9572920c84f",
            "input": "Phenytoin toxicity: an easily missed cause of cerebellar syndrome.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ef2d4868ab9544a0bfef87c0bd3ce5a5",
            "input": "The authors describe valproate-induced hyperammonemia and mental status changes in an 88-year-old man, the first known reported case in an elderly patient.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b689b8cebfa54686bfce0911f64e8f4b",
            "input": "Temozolomide-induced desquamative skin rash in a patient with metastatic melanoma.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-48a0f77053b743b1b520898fa105d0db",
            "input": "Spectral-domain optical coherence tomography and adaptive optics may detect hydroxychloroquine retinal toxicity before symptomatic vision loss.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-765d0465042841b5822096ab35a83120",
            "input": "The two middle aged women presented with respiratory symptoms after prolonged treatment with nitrofurantoin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c487254debb94e31a3b185864d9e3375",
            "input": "RESULTS: Three patients who developed symptoms of inflammatory bowel disease (IBD) during rofecoxib exposure are described along with pathology findings.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-064d9ebf90dc4c738c3db8298c3c3957",
            "input": "NCSE, an epileptic disorder in which typical convulsive activity is absent, has previously been reported in only 4 patients receiving ifosfamide.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3836f9eee99742b19c2fa10b5216ad4b",
            "input": "After 3- to 13-month period of therapy without indapamide, glucose levels of all patients decreased and diabetes disappeared.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4a2adf80995845e1bb1bbab3bf25b512",
            "input": "CONCLUSION: There may be an association between raloxifene and the development of malignant mixed mesodermal tumor.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c226d938ee7542e6a4ea416ed7d59e41",
            "input": "OBJECTIVE: The aim of this paper is to describe a case of increased libido during fluvoxamine therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-029b87d73a5f4ec49c47d5aec969f235",
            "input": "Exacerbation of schizophrenia associated with amantadine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d9b877f821ad47b5ad842517093be3ea",
            "input": "Aminophylline hypersensitivity apparently due to ethylenediamine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0b98fff0e78247af9183d451545cd18b",
            "input": "A case of allopurinol hypersensitivity, possibly the first in a black African, is reported.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4b1c4bbbe2464a669fcb111590bd05af",
            "input": "Iatrogenic hypercalcemia due to vitamin D3 ointment (1,24(OH)2D3) combined with thiazide diuretics in a case of psoriasis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5170a52cccf94123a50152ecfe541738",
            "input": "In patients with a known access to INH, seizures should be considered to be caused by INH toxicity unless proved otherwise.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5fa04974e4114e4e936f4023c28690b2",
            "input": "High-grade atrioventricular block during dipyridamole stress testing.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-8bf8d7c8e7ec4c2287cde7d50934c5b1",
            "input": "We report a case of hepatolithiasis (intrahepatic stone) complicated by gram-negative sepsis in a 37 year old male with acromegaly being treated with octreotide.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-66ac8b3e123948bba6fb976615bb1212",
            "input": "The nodules regressed after withdrawal of methotrexate therapy in one patient and were arrested with the addition of hydroxychloroquine in the other.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4f469a99cafa417fad0ed894233f1828",
            "input": "This panic anxiety was not relieved by taking etizolam and flunitrazepam again, but subsided rapidly by the re-administration of mianserin 30 mg/day, and because of that the depressive symptom also disappeared.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-7309fa551ab34c15a0f7dde741d2e2ad",
            "input": "CONCLUSIONS: LTG overdose may result in a severe but reversible encephalopathy, a previously undescribed phenomenon.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-65f61cebb0b840918d331db7b21feec2",
            "input": "We present a case of a diabetic patient taking glyburide who was prescribed ciprofloxacin and developed prolonged hypoglycemia, which persisted for over 24 hours.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b4e90ad83f49475eb7cea28e3ad1d7cf",
            "input": "METHOD: Case analysis of a poly-drug overdose (venlafaxine, topiramate, divalproex sodium, risperidone, and carbamazepine) presenting with mixed SS/NMS features and whose clinical management suggests a practical algorithm for treatment of undifferentiated SS/NMS in critical care settings.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-fca3e84ca65e4ce693106b2274671d4a",
            "input": "Native arterial thrombosis, though recognized as a severe complication of thrombin injection, has not been well described in the literature.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a87f4c4adf2e4afbbfa22c39358fc6c0",
            "input": "Skin rash began after 2 weeks of treatment, and signs of hepatocellular failure developed 3 weeks after phenobarbital had been started.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-907a43064fed48aeb9bcc6ea8f86c4a9",
            "input": "A 74-year-old man received oral administration of pilsicainide, a pure sodium channel blocker with slow recovery kinetics, to convert paroxysmal atrial fibrillation to sinus rhythm and developed loss of consciousness two days later.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2e35ca9340494794a5d21f7197bf296f",
            "input": "We report here a rare case of ritodrine-hydrochloride-induced rhabdomyolysis in a pregnant patient with myotonic dystrophy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ef9db71d54434cff9afeb984e91d63da",
            "input": "The authors describe a case of the catatonia syndrome associated with disulfiram therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-def0470fbf914059bb6fb84b00355339",
            "input": "Common adverse events (frequency 10%) of lacosamide doses up to 600 mg/day include nonspecific central nervous system effects (e.g., dizziness, ataxia, diplopia, and somnolence).",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1f8141673e844dfb9443b2503bb28bdf",
            "input": "Does acyclovir increase serum lithium levels?",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2745e7f7fb584fdcb985bc6904648731",
            "input": "This report suggests that bleomycin lung toxicity may be reversible if treated aggressively.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9cee63694acc4a818637379b00b78f0d",
            "input": "Cystoid macular edema in a low-risk patient after switching from latanoprost to bimatoprost.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-47325f1450e448f1844ac6f0dd7ad0d4",
            "input": "We report the case of a lung cancer patient with bronquiloalveolar carcinoma (BAC) presenting with BOOP after chemotherapy with docetaxel and gemcitabine producing severe respiratory insufficiency, and simulating a progression of the tumor.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-329e1679a2344e9797497878b79ba66d",
            "input": "Polymyositis after propylthiouracil treatment for hyperthyroidism.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-8344d8808ecf47d080860add321ff7cf",
            "input": "Thrombin is highly effective for stopping intractable arterial hemorrhage during stereotactic brain biopsy; however, it is a vasospastic agent and may have been responsible for the cerebral infarctions in one patient.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-58daa2ca1e324aafa34b52ee45d0da87",
            "input": "Anaphylaxis to intrathecal diamorphine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f3a7467336a2454ab4cc8203518896dd",
            "input": "Glaucoma secondary to epithelial downgrowth and 5-fluorouracil.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ef96c3ca568241208a2b8b6772b9737c",
            "input": "A 58-year-old woman with rheumatoid arthritis (RA) developed fever, skin eruptions, leukocytopenia, and thrombocytopenia, 3 weeks after treatment with sulfasalazine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-28bc77c7a2ee4a458c710cb2a0aa3ab9",
            "input": "The potential role of propranolol in inducing central nervous system disturbances is emphasized, and the literature on the subject is reviewed.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-cf682073542749c2a843e43e9753c9f5",
            "input": "Arrhythmias and cardiac arrest have been reported during amphotericin B administration but no effective technique has been described to prevent them.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5334391b89b144658ca53c1b4d0b51dd",
            "input": "INTRODUCTION-The aim of this case report is to present a 15-year follow-up of a patient with phenytoin (PHT) intoxication with unilateral gingival hyperplasia (GH).",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2bd825a6ab24481e81d3f22700c1d911",
            "input": "We report a case of penile fibrosis after intracavernous self-injection of a combination of phentolamine and papaverine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4fb316865acd4f369e460d5a2742d80a",
            "input": "We present the case of a postictal patient with lethargy, hyperammonemia, otherwise normal liver function tests, and a therapeutic valproic acid level.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-31ec91b260b64f4dbddeb681b9ec832f",
            "input": "Investigation confirmed the diagnosis of rhabdomyolysis, and discontinuation of colchicine resulted in resolution of clinical and biochemical features of rhabdomylysis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-33a8298ef0ec4137b7e5ff9425974091",
            "input": "Thrombotic stroke associated with the use of porcine factor VIII in a patient with acquired haemophilia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-15a884da78c3460f9e323d1f0025f334",
            "input": "OBJECTIVE: To report a case of colchicine-induced myopathy in a teenager with familial Mediterranean fever (FMF).",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d201f06ca03a43ca94b126095bc721a1",
            "input": "Ibuprofen-induced meningitis: detection of intrathecal IgG synthesis and immune complexes.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-fb3a873a940b4d889518c3b60427ac1e",
            "input": "Atypical ventricular tachycardia (torsade de pointes) induced by amiodarone: arrhythmia previously induced by quinidine and disopyramide.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e504796286624dee9b58b45ae778479c",
            "input": "A patient with intracranial osteosarcoma that arose 16 years after radiation therapy for hereditary retinoblastoma developed fatal cerebral edema and brainstem herniation after she received a single dose of intravenous methotrexate.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-fe4cd000467a4b6db8fa585d1dfbb20b",
            "input": "Hyponatremia in patients treated with lorcainide, a new antiarrhythmic drug.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-18cd5136e8f449ea9204f1d99488f531",
            "input": "Captopril-associated \"pseudocholangitis'.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c44483ab1407484ba08cb916d2f13de2",
            "input": "a 67-year-old man with bipolar disorder developed a Creutzfeldt-Jakob like syndrome during lithium carbonate treatment.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a64cefa9335143ecb9d151d0050eb99b",
            "input": "Painful neutrophilic skin lesions were observed in two children receiving granulocyte colony-stimulating factor (G-CSF) for treatment of idiopathic neutropenia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-93b58f88bdff4142bf29528c09495bbc",
            "input": "BACKGROUND: Colchicine has a known adverse effect on wound healing through its inhibitory effect on tubulin-dependent cell functions and through collagenase activation.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-cd1572ee5c5d47ab95e8e10e56c5ebe4",
            "input": "2-CdA induces lymphocytopenia, which may explain the improvement in this patient's psoriasis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d98b8291392f4c7f9ab4ec8cded5ae95",
            "input": "Prominent positive U waves appearing with high-dose intravenous phenylephrine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2f256799fb8643c7a27a00a652ddd764",
            "input": "Although transient increases in ectopy after bretylium therapy have been described, presumably due to catecholamine release, the occurrence of life-threatening ventricular arrhythmia leading to cardiac arrest has not previously been emphasized.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e102658c208449f1b04f1f610c83e905",
            "input": "Here we present the case of a generalized lichen nitidus with involvement of the palms in a patient with hepatitis C after systemic treatment with interferon alpha and ribavirin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-32d88f6ddd0848fa9c7b477fb7e3f03f",
            "input": "Acute respiratory distress syndrome after rituximab infusion.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-001f727146cc494fa684261b76972fe1",
            "input": "There have been numerous case reports of hyperglycemia with olanzapine in the literature, but none reported hyperglycemia within days of initiation of the medication.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-7396e6694ca742dcb7f2330589fb0517",
            "input": "In this paper, we report a case of 3 years-old boy who developed acute onset tetraparesia following a viral respiratory infecction and hepatitis B vaccination.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2867d0cb34d84c009d2c878acc600143",
            "input": "Acute renal failure following intravenous immunoglobulin therapy in a HIV-infected patient.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-7a1dd48cbcd14bbfa56c5cb34ae5f24b",
            "input": "We report a case of an infant with complex congenital heart disease who was placed on captopril for afterload reduction following cardiac surgery and subsequently developed pulmonary infiltrates with eosinophilia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-fdc0215502334660b935ebeb525beaf7",
            "input": "Halothane hepatitis and prompt resolution with methionine therapy: case report.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f09c671e140244a1b05834181f5b1222",
            "input": "Clofazimine enteropathy caused by crystal deposition can be life-threatening.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-428b180021ea4983b1611f11c9328907",
            "input": "Metipranolol associated granulomatous anterior uveitis: not so uncommon as thought.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c4aa3e0f672c4c28960d7c04344707d1",
            "input": "Severe erythroderma as a complication of continuous epoprostenol therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6d50ca64ac4240dba78ac765d32c8148",
            "input": "STUDY DESIGN: Case report of a 31-year-old woman who presented with toxic myelopathy due to intrathecal administration of doxorubicin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-de55f546bf5e410aa036b07e16b16576",
            "input": "CONCLUSIONS: Acute severe hepatitis though rare is occasionally observed with EGFR inhibitors gefitinib or erlotinib.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-fe72059f2e674f0fb9f93eba55a7fe62",
            "input": "An infertile patient with amenorrhea-galactorrhea syndrome lost vision during a pregnancy occurring after Bromocryptine treatment.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-88b9607cc1354e84a059c4da67fdbc50",
            "input": "We describe the clinical and liver biopsy morphologic features for 4 patients with minocycline-induced autoimmune hepatitis (group 1).",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a066df1d62294e65b9334a2d258a36a4",
            "input": "We describe a patient with acute myeloblastic leukemia (AML) who developed nephrotic syndrome after receiving several courses of chemotherapy, including macrophage-colony-stimulating factor (M-CSF).",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c59a1da74233471aaf1408c5cbec18f9",
            "input": "There are no previous reports in the literature about the emergence of CML during treatment with hydroxyurea.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-221fe8cd706845f1b076803a79ab0f83",
            "input": "Visual system side effects caused by parasympathetic dysfunction after botulinum toxin type B injections.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-fcdcaf1ea80e4a0aa4d2ccb2799a8e4f",
            "input": "A lethal complication of peripheral vein vasopressin infusion.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b5389bd5a23c4e9f89330970dff0cccd",
            "input": "Anaphylactoid reactions with intraperitoneal cisplatin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0e7e3dc5e34f4680bed42828ade68154",
            "input": "A 15-year follow-up of phenytoin-induced unilateral gingival hyperplasia: a case report.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-076936836df043bc942061f9774360f5",
            "input": "PURPOSE/OBJECTIVES: To describe the pharmacogenetic syndrome of dihydropyrimidine dehydrogenase (DPD) deficiency, which predisposes patients with cancer to potentially lethal adverse reactions following 5-fluorouracil (5-FU)-based chemotherapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0e13dd7548724aae86b95a1bb4ce1a59",
            "input": "Clozapine induced polyserositis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-80ad9cddcd764a83ac0738f06fa97dbe",
            "input": "Two cases of childhood-onset schizophrenia associated with clozapine-induced akathisia responsive to beta-blocker treatment are described.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-7072210c70784ad7bf550a7edad6b145",
            "input": "Gigantomastia induced by bucillamine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-68ceaf015f8f4018a9a7596c361d6844",
            "input": "CASE SUMMARY: A 61-year-old woman with no apparent risk factors for liver injury developed acute hepatitis one week after the final dose of a long-term course of pulse itraconazole therapy (200 mg orally twice daily, 1 wk on, 3 wk off, for 24 wk) for onychomycosis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6850da624b2f42808dd7c93b00ff6137",
            "input": "We report a rare case of recurrent (stuttering) priapism in a patient with protein C deficiency while maintained on Warfarin therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3afc989676bc4b5e8459305facaf3cf4",
            "input": "We report 3 children with epilepsy who developed facial motor tics after initiation of CBZ for complex partial seizures.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1afa3b167d4a472bbd1c8ec5ea33ddc1",
            "input": "We present a case of hemolytic-uremic syndrome that developed during the 4th cycle of combination chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5c1953999865487da8e6ee696badfb5e",
            "input": "After an extensive review of the literature, we believe that this is the first communication of the successful use of amiodarone to control hyperthyroidism in a patient with PTU-induced fulminant hepatitis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-95e25c890fed4d43902c1d129e40e81a",
            "input": "It is the first case of ciprofloxacin-induced VBDS successfully treated with tacrolimus.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a40c70b25f68405ab28e7d59634b8ab2",
            "input": "However, he developed acute renal failure, hyperkalemia, and hyperuricemia 30 d after receiving the sorafenib treatment.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-59020a286fc24a36af78c7505ee3eaa2",
            "input": "Hypersensitivity to carboplatin has been reported in up to 44% of patients receiving this antineoplastic agent, usually occurring after several courses of treatment.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-7015f69da67b481697e1007b8a374c55",
            "input": "Induction of rapid mood cycling during L-dopa treatment in a bipolar patient.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3d61d207b2994de69f92ade8a461be67",
            "input": "However, one patient exhibited severe hypersensitivity reactions including cardiac arrest and apnea, and another four patients developed eruptions, hypotension, and tachycardia soon after administration of CBDCA.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1753005a422c4b4586510ab0acc754b9",
            "input": "This report presents a case of acute lung injury developing within hours after administration of mefloquine for a low-level Plasmodium falciparum malaria, which was persistent despite halofantrine therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b97e61046b864f69a9ddc84f9b5060db",
            "input": "A 58-year-old woman developed unilateral acute angle-closure glaucoma four days after the application of a patch of transdermal scopolamine delivery system (TRANSDERM-V).",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-de8e8ad125a04da5a96690fd7024b67f",
            "input": "Severe hypo-alpha-lipoproteinemia during treatment with rosiglitazone.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-664471e06b154a8baadb2b90ad518383",
            "input": "Co-trimoxazole red cell aplasia in leukaemia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-aa0b5bc672d44baca706a3af824cf72f",
            "input": "OBJECTIVE: To report a fatal case of toxic epidermal necrolysis in a man who was treated with oral ofloxacin for epididymitis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3cfd91787b5a46e6a42abefbea2856b9",
            "input": "OBJECTIVE: To report the case of a young woman with Graves' disease in whom ototoxicity developed because of propylthiouracil (PTU)-induced antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-7331c5ca2fae42dfbbc5376e630c21fc",
            "input": "The presented patient was treated with 200 mg TCA and developed Cushing's syndrome 6 weeks later (cortisol and ACTH concentrations were below limits of detection, TCA concentrations were > 3 micrograms/l).",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a7b04829484b4529bc634e4068cbe979",
            "input": "We describe a case of intraoperative gelatine-induced anaphylaxis whose diagnosis was delayed as the use of gelatine during surgical procedures was omitted for two times in patient's medical records.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-36af33a54a6b4310879cf38eeb71e705",
            "input": "This case suggests that sarcoidosis and pravastatin, two entities not frequently associated with myotonia, may interact in a synergistic manner to produce severe clinical myotonia in humans.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-de7ca7de589444ad9f2411a602b847ed",
            "input": "Two patients with imminent gangrene of the extremities caused by ergot-induced arteriospasm underwent mechanical dilatation of the arteries when conventional measures such as anticoagulation, vasodilation, and sympathetic blockade produced no improvement.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ec17b83228ab403ead0f0a5b837ec497",
            "input": "Establishment of diuresis with fluids and IV administration of calcium may provide successful treatment of magnesium toxicosis in horses.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-fdb04cd5de2942dd931e3b8f3095ea63",
            "input": "Subacute cholestatic hepatitis likely related to the use of senna for chronic constipation.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-97ad2a268c224af68056a30126d19076",
            "input": "Paradoxical seizures in phenytoin toxicity.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2d27da50ff904a409ee6aa5e7e4e303f",
            "input": "We describe a case of clozapine-induced seizures in a patient with treatment-resistant schizophrenia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2de6abaa2c034e2f85c1b449f9bc9ed8",
            "input": "Three days after intravitreal injection of bevacizumab, acute ocular ischemic syndrome occurred.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4e2b1a3285214b65af3f8314b8ab7c26",
            "input": "We report a 50-year-old male patient with a 15-year history of psoriasis including mutilating psoriatic arthritis, in whom the withdrawal of cyclosporin A induced a generalised pustular exacerbation and a aggravation of the joint condition.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-344aef733dcb4b46b64017d5cd0ebe5a",
            "input": "We describe a case of severe aplastic anemia (AA) that was probably induced by lenalidomide.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f9bb2e08df1e4bd8bb9693fde6961952",
            "input": "Two years later, 24 hours following an increase in the dose of disopyramide from 300 to 600 mg/day, AVT with syncope occurred; isoproterenol abolished the arrhythmia instantly.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-33514786c2834ae0bb633af072e92b3d",
            "input": "Cholesterol crystal embolization-associated renal failure after therapy with recombinant tissue-type plasminogen activator.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-773ffc7299984fcdb42f60e45cfc727f",
            "input": "This case report describes an adolescent with severe lupus erythematosus who received cyclophosphamide (CY) paired with taste (cod liver oil) and smell (rose perfume) as conditioned stimuli.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4b710b508c134aa3a4f58b0f7729af37",
            "input": "This is the first report of a fluoxetine-related death in a child with a confirmed genetic polymorphism of the CYP2D6 gene that results in impaired drug metabolism.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4e0a059ce5a44ebc9f4af74aabdc3535",
            "input": "These novel findings may offer specific therapeutic targets in the treatment of BCNU-associated pulmonary fibrosis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-38836bbc635a4bd8b190e71fac545680",
            "input": "The HIV protease inhibitor indinavir may cause nephrolithiasis and interstitial nephritis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-94c40b384e3043ee935110238bf9469e",
            "input": "OBJECTIVES: The authors described a case of Hashimoto's disease during interferon-alpha (IFN-alpha) treatment for chronic viral C hepatitis in a patient with the specific genetic susceptibility associated with the thyroid disease.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-53785cdad1b6415393d805cd3e95906f",
            "input": "We report 3 cases of children with acute lymphoblastic leukemia who developed seizures and altered sensorium after L-asparaginase therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4d0040f51337421484b7bd0773e10bbb",
            "input": "We describe two patients with rheumatoid factor-positive, polyarticular-onset juvenile rheumatoid arthritis in whom accelerated nodulosis developed during methotrexate therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-8b4beeff9e1446fe9c9962f49d43747a",
            "input": "Flucloxacillin-induced aplastic anaemia and liver failure.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-312f356238094b21bc57ff1640a67af2",
            "input": "Progressive interstitial fibrosis with roentgenographic honeycombing developed in the case of a psoriatic patient who had been on a regimen of methotrexate for 18 years.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e900de3a0c694f9188479c524207ce91",
            "input": "Lansoprazole-induced thrombocytopenia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1ae7a1b6dedb4fc9a2e6358cde9d6cd1",
            "input": "RESULTS: A 52-year-old woman with Parkinson disease who had taken amantadine for 6 years had bilateral corneal edema for 2 months at baseline.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9db7836b4d944cd5b9c9e8fcf2656050",
            "input": "Liver disease induced by perhexiline maleate.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e981158b516f44338833bd4517341c06",
            "input": "Charcoal haemoperfusion and cysteamine therapy led to the rapid removal of the paracetamol from the body and consequently prevented the development of severe hepatic necrosis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1fd06300f46b43439bdf106bab0c0eb0",
            "input": "Protamine allergy as a complication of insulin hypersensitivity: A case report.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f64697de8e23474abff5f8a08926fcde",
            "input": "OBJECTIVE: To describe a probable case of transient global amnesia caused by propafenone.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-8c769aad00af47729872633ab3385e1c",
            "input": "PVT during chemotherapy in children is a rare event and appears to be closely related to intensive chemotherapy containing busulfan and to be associated with HVOD.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5d27cd4362b043d19a318f255047705b",
            "input": "A unique case of a transient, nonpigmenting fixed drug eruption caused by the radiopaque contrast medium iothalamate is reported.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-03c3136f50c24ffdb94ce16a6d534f0e",
            "input": "We describe two dark-skinned patients who developed hyperpigmented skin and tongue lesions during combination therapy with IFN and ribavirin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-88dc4d9b21a34fd19ab32b1b2d3db68a",
            "input": "In these patients, long-acting octreotide may trigger serious hypoglycemia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-82aaeb6579094c529abd41413329e5ac",
            "input": "Drug eruption caused by azathioprine: value of using the drug-induced lymphocytes stimulation test for diagnosis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-35a6efe4181c4895af8be46279cae985",
            "input": "Two patients treated with alprazolam had histories suggestive of a bipolar disorder and developed lithium-responsive manic episodes.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2e0e9c44a5e34b6684e32f0810483e25",
            "input": "PURPOSE: To describe bilateral optic neuritis that occurred as an adverse effect of recombinant and natural interferon alpha administration.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-35a7b5dc3211424c85374a56f84044e9",
            "input": "To the best of our knowledge, this is the first reported patient with captopril-induced pemphigus in whom no new lesions developed after subsequent treatment with enalapril.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a8b1150bee4647d495efd05e33d1278c",
            "input": "Salicylate hepato toxicity in rheumatic fever.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-44ffcb47f4a84a12aa9291d8c32ef136",
            "input": "A case of phenytoin-induced hepatitis with mononucleosis is reported, and syndromes associated with phenytoin hypersensitivity reactions are discussed.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-362b521e8bff4741a537a25e448150b6",
            "input": "EEG abnormalities were observed in two of the nine children during chlorambucil therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-677f9d68e3d44e6f9d586bc54dc2b81b",
            "input": "Contrary to previous recommendations, our experience cautions against the further use of high-dose cytarabine in patients who develop PPE, and is a timely reminder of the potential toxicity of this agent, which is now increasingly being used as first-line treatment in the management of haematologic malignancies.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4305445e2eaf47398b6bc23121ada320",
            "input": "We describe a patient with idiopathic RLS who developed augmentation after 8 months of levodopa treatment.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1ab60ea822d844799f3a2cb477f55cb2",
            "input": "BACKGROUND: To assess the nature, incidence, and risk factors of retinopathy associated with pegylated interferon and ribavirin combination therapy in chronic hepatitis C patients.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4df2d0e93f38474f8a38f688befa1147",
            "input": "Recognizing early signs of HMSN, such as areflexia and pes cavus deformity, can prevent severe neurotoxicity of polychemotherapy by avoiding vincristine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-da81701e9a124336a03bb8bc723b8f09",
            "input": "To our knowledge, this is the first case report that demonstrates the occurrence of fever with low-dose amifostine therapy without the manifestation of accompanying rash or hypotension.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c02c9ce59ce145eda7e7f02127bd41e0",
            "input": "Reversible sclerotic changes of lumbar spine and femur due to long-term oral isotretinoin therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-49a784036c57442db36660efd0a8eaa1",
            "input": "Drug-induced fever should be considered in patients who have unexplained high temperatures during diltiazem therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-31cb5a14bc144ecca60850957928f8f9",
            "input": "Four days after the initial injection of 3.6 mg of goserelin acetate, severe dyspnea developed due to worsening pleuritis carcinomatosa, which was considered as a flare-up.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6b3061f226e14151b2e80cf4f6904845",
            "input": "Brugada type electrocardiographic changes induced by concomitant use of lithium and propafenone in patient with Wolff-Parkinson-White syndrome.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-173be32643574abdbab68d5f172d9891",
            "input": "Minocycline as a cause of drug-induced autoimmune hepatitis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-58df0dc88d2a498da82aa99dbf3bf70f",
            "input": "The fetal valproate syndrome (FVS) is characterized by distinctive facial appearance, major and minor malformations, and developmental delay.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5edb24f579484081b5e2da470f5d9f40",
            "input": "Recombinant VIIa concentrate in the management of bleeding following prothrombin complex concentrate-related myocardial infarction in patients with haemophilia and inhibitors.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ca6b35a8fad048f3847b39f9340dd294",
            "input": "We conclude peripheral neuropathy with 5-FU is rare.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-50366e9a17474cbd8a0568c12637b655",
            "input": "After ruling out a hydrotelluric source of fluorine, the patient's fluorosis was linked to chronic use of niflumic acid, following the publication in 1978 of the 2 previously reported cases affected by this drug.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-03960bea5465495582b769d2bef8ccf9",
            "input": "Colitis as a manifestation of infliximab-associated disseminated cryptococcosis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-01e6988d0126424891b26956712e905d",
            "input": "This report rules out other causes of toxic epidermal necrolysis and implicates ofloxacin in what appears to be an atypical presentation of drug-induced toxic epidermal necrolysis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-8c7431da975f42689540223b9fca2780",
            "input": "Can propofol precipitate pancreatitis in patients with Cushing's syndrome?",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5b2c5a97146b4585a77bac03ae66974f",
            "input": "Hepatitis with bridging fibrosis and reversible hepatic insufficiency in a woman with rheumatoid arthritis taking methotrexate.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-bc9fe40c4e984e048b651cf6078ecb44",
            "input": "This case study describes an atypical case of refractory, sodium warfarin-induced necrotizing fasciitis and myonecrosis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-05ba83be63ac4abbad295176fba87045",
            "input": "Unusual pigmentary changes associated with 5-fluorouracil therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-cfad3dae2d8c4b25a20815716356d491",
            "input": "METHODS: Three patients with apparent itraconazole-induced liver injury were studied.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-132c8c2bc17b48bd864db6dc41a3b021",
            "input": "Occasionally, despite good therapeutic response, clozapine must be stopped due to dangerous side effects such as agranulocytosis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a0c5c65cd9144476a68fc9752e895097",
            "input": "This case suggests that acyclovir when given intravenously in doses of 10 mg/kg may result in increased serum lithium concentrations.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-bdcd3d57925947f1afd1fdb8417637b1",
            "input": "Although adverse reactions to protamine are reported infrequently and are usually mild, we recently observed the first fatal case of type I anaphylaxis resulting from protamine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-34598c4ff6d941e29098ad73a3ab26fb",
            "input": "We report a case of codeine intoxication in the neonate, in which the drug was prescribed for cough control during an emergency department visit.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-625caf0e2074403c92810b2e1c11d690",
            "input": "We report a case of acne fulminans occurring during treatment with 13-cis-retinoic acid for cystic acne.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6d026a80594546bf993fc4221854ab1b",
            "input": "We report the first case of doxycycline-induced hypoglycemia in a young nondiabetic man.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c80b18ed174d41df9bc2f5cc0c88cf98",
            "input": "Four cases of oesophageal damage associated with ingestion of the urinary anti-spasmodic agent emepronium bromide are described.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ecbb66eac56244fc9bc2bfb199d11100",
            "input": "DATA SYNTHESIS: Genetic deficiencies in DPD, the rate-limiting enzyme responsible for 5-FU catabolism, may occur in 3% or more of patients with cancer putting them at increased risk for unusually severe adverse reactions (e.g., diarrhea, stomatitis, mucositis, myelosuppression, neurotoxicity) to standard doses of 5-FU.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1cc12399ed0c453581663a75f96cc57a",
            "input": "We describe the side effects of 5-FU in a colon cancer patient who suffered severe mucositis, desquamating dermatitis, prolonged myelosuppression, and neurologic toxicity that required admission to the intensive care unit.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-bb628513eb744580b858b11cc4933f2f",
            "input": "We describe two women who developed HUS after MMC therapy and presented massive pulmonary bleeding.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-8c1e89528bf844c3b85363bc9f7a4e53",
            "input": "Seizures and extrapyramidal symptoms in a patient with Tourette's syndrome, Asperger's syndrome, and multiple sclerosis treated with interferon beta-1a and clomipramine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-869cb542448e426ca0ae20369fbe689d",
            "input": "A case of anaphylactoid reaction due solely to the use of Gelofusine in a patient with non-haemorrhagic hypovolaemia is presented, with a discussion on the management and the use of allergy identification jewellery.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-293f1a39a3f043e18685bab55d4af94f",
            "input": "Musculoskeletal complaints were the presenting symptoms in four of 44 children (9%) treated for relapsed Wilms' tumors with ifosfamide, a derivative of cyclophosphamide.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-06b854ecb2b44e24bab7be88ae84b24f",
            "input": "A patient is described who developed a rapid onset of pulmonary fibrosis following treatment with a new non-steroidal anti-inflammatory drug, nabumetone.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c978825440884ce3853c46b5d53204f7",
            "input": "We report a case of 48-year-old woman with seizure disorder on divalproex sodium (Depakote) who presented with dyspnea.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4f4296f445fe41f2a61b4d13ff95d325",
            "input": "In a patient suffering from rheumatoid arthritis, we report the first simultaneous occurrence of two side effects of low-dose methotrexate: an acute megaloblastic anaemia and a pneumonitis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9504bbed5c374a65803f5c97ebab3870",
            "input": "Can ketamine prescribed for pain cause damage to the urinary tract?",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c75d9c2cc9084c5c80304aca48578eda",
            "input": "OBJECTIVE: The purpose of this study was to report the concomitant occurrence of multiple squamous cell carcinomas and diffuse nail hyperpigmentation associated with hydroxyurea treatment, and to describe a successful therapeutic approach using imiquimod 5%.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-da7abd4bbc8a467eabd3b952a5fd3143",
            "input": "CONCLUSION: Although a definite association has not been proven, clinicians should be aware of the possibility of agranulocytosis while using quetiapine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-beafb832692e40e5ae03a45c63c2ecd4",
            "input": "Argatroban is hepatically cleared and may be the preferred direct thrombin inhibitor in the presence of significant renal impairment, but conversely has prolonged effects in hepatic failure.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-bae0c80387b847be98eaf2700bbb4790",
            "input": "Magnesium toxicosis in two horses.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6c9444b9f4ea498dbe4e2d92040e8259",
            "input": "We report four cases of hemodynamically significant pericardial effusion in patients with refractory lymphoma who were receiving gemcitabine, all of whom had a history of mediastinal radiation without subcarinal blocking.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-98dea9dc3f274263a95b79e7dcd35cb1",
            "input": "Stuttering priapism complicating warfarin therapy in a patient with protein C deficiency.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-bf53eb77a1de4c9db8623ac57ac73080",
            "input": "The patient completed a 10-month follow-up, maintaining a complete resolution of the treated skin lesions; however, the development of a painful hand ulcer, possibly associated with the hydroxyurea, and new skin cancers were observed at the last follow-up visit.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-db51ec995285438dbf24f1247b668f40",
            "input": "In this case, discontinuing piroxicam, a nonsteroidal anti-inflammatory drug, and starting a palliative treatment plan helped resolve a patient's ulcers.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f314f824ec9541a9b751038247f16d2d",
            "input": "Ulcerative proctitis in juvenile systemic lupus erythematosus after ibuprofen treatment.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a1f010a3a9694fd4b5ea142d78ef0f92",
            "input": "This is the first report of an adverse effect of fetal renal circulation by maternal ingestion of nimesulide.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-945507f07b774a858f70d8b47341702b",
            "input": "Adriamycin-induced cardiomyopathy aggravated by cis-platinum nephrotoxicity requiring dialysis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6b1c5ca9d8d14b85b1ec3fc08d139aa8",
            "input": "According to the Naranjo adverse drug reaction probability scale, tigecycline was the probable cause of her acute pancreatitis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-edb090e096fe4caa8740d6435303505e",
            "input": "Ibuprofen rarely causes lower gastrointestinal adverse reactions but has been implicated in systemic and local side effects in patients with lupus.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-198b25f03e1c496993887eacf15823a3",
            "input": "Renal damage associated with long term use of lithium carbonate.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6460ad956874443faadbc80b47a42385",
            "input": "We believe that this is the first report of secretory carcinoma of the endometrium associated with tamoxifen use.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0fdd26677eec4ae2a27f3b26a3d859a7",
            "input": "A 26-year-old Japanese man, who had been receiving medical attention for ulcerative colitis for one year, presented with diffuse erythema and pustules on his face and trunk, malaise, and fever up to 39 degrees C one day after the administration of salazosulfapyridine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-24364a23577b425389686e8c88887066",
            "input": "After the second infliximab infusion, he was found to have a severe transient neutropenia (0.5 x 10(9)/L).",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-19e86f85a1464f71b361d19d6a4a48f1",
            "input": "Therefore, amantadine was permanently discontinued and the cornea cleared again.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2d86f6375604408583e9d78685a6c4fd",
            "input": "Oncologists supervising future clinical trials for lung cancer should be alert to the fact that sorafenib can potentially induce serious interstitial lung disease, although this might depend on racial differences.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-188d1682f80c4e118c5b49213dfac78d",
            "input": "Methemoglobinemia: an occupational hazard of phenylpropanolamine production.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4b4b328ca7b343a6993b438423c15573",
            "input": "We conclude that MB is an effective treatment for ifosfamide-induced encephalopathy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3e05ddc3857c48dfab1ac1eed1ea5893",
            "input": "Azathioprine-induced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-545655629cc4454284ecb8001191c65f",
            "input": "Generalized maculopapular and papular purpuric eruptions are perhaps the most common thionamide-induced reactions.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6302235abaa54ef0b3a1da97b32a2531",
            "input": "On the fifth day of tocolysis with magnesium sulfate, nifedipine, terbutaline and betamethasone, edema developed in both labia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-51bf338e2eec4c818da159dd3d218a75",
            "input": "Depressive symptoms disappeared after interferon therapy was stopped.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-96510b859389446bacd9a7cbae9d0a93",
            "input": "Rifampicin-induced renal failure.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-70e1567af89b440da077d66c156b956c",
            "input": "The NZ Pharmacovigilance Centre has received 7 additional reports of severe infections in patients with RA taking leflunomide.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-dd173423634040c2866270d6742c5b3e",
            "input": "Cis-retinoic acid (RA) may further increase the risk of developing BMTN.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-436ca8fb3e5b4940bc13e958b4bc5fad",
            "input": "A patient with generalized MG was effectively managed with MM but developed CNS lymphoma after 3 years of treatment.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2d0535f158f045c1867f46090f10154e",
            "input": "He had also developed elevated serum ammonia levels while on valproic acid.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2a5aa0787e744f4da3c7c3e695440560",
            "input": "There have been many reports of probable lithium-induced organic brain syndromes occurring when serum lithium levels are within or close to the therapeutic range.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d938143b721e45e880ed0a57b3888796",
            "input": "She was administered metoclopramide because of nausea and, within 2 hours, developed agitation, dysarthria, diaphoresis, and a movement disorder.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3f423128d1f247779b57372840249dcf",
            "input": "Paradoxical ventricular tachycardia and fibrillation after intravenous bretylium therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-eb4dda340534458a8e23fb7da1052014",
            "input": "High-dose methylprednisolone in a pregnant woman with Crohn's disease and adrenal suppression in her newborn.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-321828cf0fe948ea9df77fdfa3964b29",
            "input": "A case of basilar invagination which is thought to have arisen from the patient's intrauterine exposure to phenytoin is presented.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c45e12ec4d4a4f9d86df85cf31acc620",
            "input": "The case of a 29-year-old man suffering from falciparum malaria disease who got a reversible hearing loss from quinine therapy is presented.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a1f2f6fa0a7b46209eb51f70c0bc17c4",
            "input": "Chlorambucil central nervous toxicity: a significant side effect of chlorambucil therapy in childhood nephrotic syndrome.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ef505791e053430a802f5a06199b227e",
            "input": "We report a case of biopsy proven myositis whose symptoms began within 10 days of receiving leuprolide acetate therapy for prostate cancer.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-67067c64a9a74e04874c3fc92351b9ff",
            "input": "CONCLUSIONS: This is the second case report that describes gemcitabine-induced radiation recall in rectus abdominus muscles after gemcitabine-based radiation therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f136faae00514461b034c17521cae0b5",
            "input": "Of particular interest in this patient is the fluctuation of the QT interval at a stable dose of methadone, suggesting that a single normal electrocardiogram (ECG) does not guarantee that the patient is not at risk of ventricular arrhythmias.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-58fc8698b3c74917a634387ac92e18d1",
            "input": "Within 3 weeks of beginning continuous daily isoniazid and rifampin therapy for pulmonary tuberculosis, a patient developed acute renal failure.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6ff0327f8b4a47fca484baa2cf1acb28",
            "input": "Progressive anemia following combination therapy with interferon-alpha and interleukin-2 in a patient with metastatic renal cell carcinoma.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-dd55a5d54ec84900ae25c133e9eaf351",
            "input": "PURPOSE: Topiramate-induced angle-closure glaucoma (TiACG) is believed to be related to its sulfonamide moiety.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6537393d34c1459d9435cfdf4af3d899",
            "input": "A 57-year-old woman developed pulmonary sarcoidosis during therapy with interferon beta for advanced renal cell carcinoma metastatic to mediastinal lymph nodes.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3cba05a5a9c94e4783815551ea5c3ef0",
            "input": "We herein described an additional patient with BCR-ABL (ela2) positive acute lymphoblastic leukemia who developed tumor lysis syndrome after 10-day treatment with imatinib.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d3e6756e21244c88bf1d4c295a6d60ce",
            "input": "Myoclonus associated with continuous dobutamine infusion in a patient with end-stage renal disease.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1b27a3dfc72a404aa06b5def6da1c14e",
            "input": "The occurrence of neuromuscular blockade and the resulting potentiation of muscle relaxants during magnesium sulfate (MgSO4) administration is well known.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3f786c4a59434cdaa27505189bb62df0",
            "input": "Stupor from lamotrigine toxicity.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0b5de830b8d04d618526d84e5c3225fa",
            "input": "Rapidly developing hyperglycemia during treatment with olanzapine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-13511f942ca64be9ad949f517d293691",
            "input": "Allergic contact dermatitis to compound tincture of benzoin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-25e2be5810454fc8bff08f1a05f859dd",
            "input": "Tetany in a child with AIDS receiving intravenous tobramycin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2190d3010537485b8cc4c448faa11cfd",
            "input": "Central pontine myelinolysis manifested by temporary blindness: a possible complication of lithium toxicity.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1a925749a4d448bb8bf14395901d6865",
            "input": "Carbamazepine-induced hyperammonemia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2ee4b5a1913b43029cdcb7facd748e94",
            "input": "To develop information on the relative rarity or frequency of neurologic worsening with the initiation of penicillamine therapy, we conducted a retrospective survey of 25 additional patients with Wilson's disease who met the criteria of presenting with neurologic disease and having been treated with penicillamine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-cda36b3f9d4a423982b3043154b181e9",
            "input": "This is the first report of non-convulsive status epilepticus provoked by tiagabine in adolescent patients.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5a5fef4873534280a34e62e2624a6371",
            "input": "Progressive interstitial lung disease from prolonged methotrexate therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d2699c8f118948249aaee6e6a306c99e",
            "input": "Traumatic late flap dehiscence and Enterobacter keratitis following LASIK.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c73bf61fd58d44219bdeed59ee09b106",
            "input": "Multifocal inflammatory leukoencephalopathy associated with levamisole therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-942b2602efa64b27ac4197169ad77a54",
            "input": "OBJECTIVE: To describe two cases of rhabdomyolysis in patients taking lovastatin that were precipitated by the use of the newer macrolide antibiotics clarithromycin and azithromycin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b4aeb9120ba142a9b61d431268725a90",
            "input": "Subfulminant hepatitis B after infliximab in Crohn's disease: need for HBV-screening?",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e575560f9558489bbff4bb2901d8359b",
            "input": "Suspected ciprofloxacin-induced interstitial nephritis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-75dc386d770945009b4186203e91e893",
            "input": "In two patients, apomorphine remained effective in the morning, but increased the intensity of the dyskinesias in the afternoon.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-361ad381522a41c3ac73d59f757da694",
            "input": "After the dose of methylprednisolone was reduced from 40 mg to 20 mg i.v. q6h and shifted to other anti-asthma treatment by procaterol metered dose inhaler via spacer, the psychotic reaction disappeared a few hours later.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-bd5caee1e3e14f03aa9178acbccabdcb",
            "input": "The literature search found 12 cases of radiation recall caused by gemcitabine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-7ae1369815d247f4a88ca498470a937a",
            "input": "CONCLUSION: The results suggest that olanzapine may be useful in treating patients with clozapine-induced granulocytopenia without the risk of recurrence of hematologic side effects.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-964ac79e53724e57adcbecab1e90c341",
            "input": "He was diagnosed with possible serotonin syndrome; his symptoms resolved after clomipramine was stopped but before clozapine was restarted eight days later.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ac26068d741f48edb77a4f747bd5be32",
            "input": "A case of priapism associated with trazodone is described.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5f3b530a6f354298a7af26f34beae6b8",
            "input": "Acute coronary syndromes can be associated with the infusion of rituximab.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b066cb8ca14c459e87680bad70e93d5e",
            "input": "Duodenal ulceration: a complication of tolazoline therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c3b5ab902e0348019d5400fe7e75b2ce",
            "input": "Cholestyramine induced hyperchloremic metabolic acidosis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0baecc233f484106aa3dfeaa55a2e189",
            "input": "When vague symptoms develop during desmopressin therapy, hyponatremia must be considered as part of the differential diagnosis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4486f818f65e40c988c52eb76389dd55",
            "input": "Interstitial granulomatous dermatitis associated with darifenacin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-01dff67b6bae4f06a05d51b4fa24d76c",
            "input": "The epivodes of NMS occured under treatment with clozapine, risperidone, and amisulpride.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-40985596a9384795afc5401fa25e2461",
            "input": "Adult respiratory distress syndrome after treatment with pegylated interferon alpha-2a and ribavirin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-71717a6f1a9945e0a7acbddc4f6f257b",
            "input": "OBJECTIVE: To determine the frequency of weight loss in patients treated with leflunomide for rheumatoid arthritis at an arthritis referral center.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-cc4c73604afe47f59acf632c04b69d77",
            "input": "This report highlights a case of drug-induced dysphagia in a patient receiving haloperidol for obsessive nocturnal thoughts and auditory disturbances.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d7dfd5a121b2433ba58aeaf3e97fce2b",
            "input": "METHODS: The patient required insulin desensitization for severe urticaria, angioedema, and occasional wheezing resulting from her insulin dose.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ef025f7cf5924f74b028b614f97d8acf",
            "input": "Beneficial effect of low-dose mianserin on fluvoxamine-induced akathisia in an obsessive-compulsive patient.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d344f2fe68084fa2b02507c64bcbdeac",
            "input": "CONCLUSION: Hypersensitivity reaction should be considered in patients who develop recurrent eosinophilia and deterioration of pulmonary function following the use of tobramycin by inhalation or by intravenous administration.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0097ed2f5f9b4f7eab3441b34ab9ee5c",
            "input": "In each of the three reported patients, alteration of eyelid appearance with deepening of the lid sulcus was evident as the result of topical bimatoprost therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b03f8ea359194b1892424c5b9a93a95a",
            "input": "Within 24 hours of fluid restriction and cessation of desmopressin, her symptoms and hyponatremia resolved.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-73508ac500bb48e58f042349c4b4b66c",
            "input": "The rash seen in this patient, who was treated with cephalexin, may be similar to the rash seen with ampicillin treatment of patients with infectious mononucleosis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-7b515757ff2141ad8a6ec25f0e1d4c16",
            "input": "Acute pancreatitis associated with danazol treatment for endometriosis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a340b79c58bb4a5db2bd701e689591a8",
            "input": "OBJECTIVE: To test the hypothesis that tumor necrosis factor (TNF)-alpha may mediate the loss and the dedifferentiation of subcutaneous fat tissue in the insulin-induced lipoatrophies of a diabetic patient who presented extensive lesions.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6ad7be4cf561427689d1906ccf8aac3c",
            "input": "Torsade de pointes represents a potential complication of chronic amiodarone therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0bd7a4ed066e43b8a0e2ec29a7c52196",
            "input": "Both had impaired lung function and abnormal computed tomographic scans, and their condition improved when nitrofurantoin was withdrawn and corticosteroid treatment commenced.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-35f433ee88e041f6a43388945d6a3e2f",
            "input": "The present report illustrates a rare case of refractory akathisia after interferon-alpha treatment and also that levodopa treatment would be theoretically and practically useful in reducing the neurotoxicity associated with interferon-alpha.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1cc9db58becf47a8a829468924e17eb7",
            "input": "We report the first case of polymorphic ventricular tachycardia with normal QT interval associated with the oral use of levofloxacin in the absence of other etiologies known to cause these arrhythmias.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5e2d4f4067124b6a8c5f87c4c107b2af",
            "input": "METHODS: Five cases of contact dermatitis due to budesonide, a nonhalogenated steroid, are described.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-263238bbcd15463093ce5850e121b3ae",
            "input": "Peculiar nail-changes in a 70-year-old woman with rheumatoid arthritis occurring after approximately 1 year of penicillamine treatment are described.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-80d4c1687c754d0fb8c165758a25e897",
            "input": "We strongly suspect that this lethal anuria was mainly due to ifosfamide, occurring in a patient having received previous cisplatin chemotherapy and with poor kidney perfusion due to transient hypotension.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e42803075f3a46d6ae0f2dd597c94536",
            "input": "Herein we report four patients who underwent liver transplantation and developed neutropenia while receiving MMF.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4e1e1af6977c4425a83ba470dcf0fc25",
            "input": "Primary CNS lymphoma regressed on withdrawal of MM.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e7e54969db1e4b3b8215f683a2211b01",
            "input": "Fulminant hepatitis associated with disulfiram.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e984b59f81dc458084ec23378977f070",
            "input": "Hepatitis following cimetidine administration.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-975b47bf721648beaadf51af0aeb68dd",
            "input": "Propecia-associated bilateral cataract.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ea705667ac1448f0af77f970c410d3c8",
            "input": "Occurrence of IDDM during interferon therapy for chronic viral hepatitis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c6069f49ac3b4841939943de4934d657",
            "input": "Multifocal electroretinographic abnormalities in ethambutol-induced visual loss.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b83218b91c4a46fd88ea85b11b3db4b7",
            "input": "Recognition of a potential drug-induced Fanconi syndrome is important when managing pediatric oncology patients previously treated with ifosfamide.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c89d8e65b3e84dd9949ce782da5c7986",
            "input": "A patient developed restless legs symptoms paralleling the course of interferon-alpha (IFN alpha) therapy for chronic hepatitis C.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0ebb7c61affb46d1a234b16426a34023",
            "input": "Acceleration of ventricular response to atrial flutter after intravenous adenosine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c5ba122f71bb47f5be1a5a9011a13b3d",
            "input": "Clearance rates of cerivastatin metabolites in a patient with cerivastatin-induced rhabdomyolysis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c739b547b67c486ebc5d036b63062849",
            "input": "Clozapine-induced eosinophilia and switch to quetiapine in a patient with chronic schizophrenia with suicidal tendencies.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4a93998aa81c4e1ebbe84322c2b2706e",
            "input": "A 58-year-old man with advanced renal cell carcinoma developed grade 3 proteinuria (8.5 g/24 h) without microscopic hematuria or renal insufficiency five days after temsirolimus infusion.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-21172aa145be4f16bab72b0a78b8ba1a",
            "input": "Acute generalized exanthematous pustulosis induced by nimesulide.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-40da3493822c4a288aeeca8e12a2392a",
            "input": "A toxic encephalopathy characterized by depressed level of consciousness, marked irritability, and ataxia developed in seven children, 5 years of age and younger, following administration of an antiemetic combination of pentobarbital and pyrilamine maleate.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e2292e3bc30c4417a5cc057795470331",
            "input": "Clinical course of macular edema in two cases of interferon-associated retinopathy observed by optical coherence tomography.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-823ee4a9e24f48c5ac3c4a1c20865bca",
            "input": "In this case, CIPS was considered to be probably associated with cyclosporine according to the Naranjo probability scale.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c0a036e6a99749e391aef9044a5645b4",
            "input": "Presented is a case of acute renal failure induced by acetazolamide therapy for glaucoma.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f582941ac8614af39687bebd879c7a72",
            "input": "However, in order to avoid neuropathic side effects, patients under thalidomide therapy should be monitored every 6 months with nerve conduction studies while taking the drug.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2fec21b3d253420fa106f9a8d12ba1ae",
            "input": "A second possibility is an interaction between clarithromycin and isradipine, potentially increasing the hepatic toxicity of isradipine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-99b97d887ce5499f802e68d7202ab55c",
            "input": "On the 3rd day, an inferior vena cava (IVC) filter was placed with a heparin flush, after which massive IVC thrombosis developed.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3c0e3eb109b24e5b966686b1e59ae843",
            "input": "This is the first report of acute kidney injury due to zonisamide-induced DRESS/DIHS.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-edfd4d0f342a45f3a7eff7798cbd02bb",
            "input": "A complex pattern of melanonychia and onycholysis after treatment with pemetrexed for lung cancer.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-11b6d083eab84554b8769516c5070917",
            "input": "Transient trazodone-induced hypomanic symptoms occurred in three depressed patients.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-af6aac4943dd4faaaed5766f5cc86644",
            "input": "In this case, it was suspected that a combination of cigarette smoking, pulmonary fibrosis, and low-dose methotrexate therapy might have promoted the development of lung cancer.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-dae90df019f043d2a2a4ccc54b67f0c0",
            "input": "This fourth type of cutaneous minocycline hyperpigmentation may be a variant of Type I, but based on clinical, pathological and microanalytical differences, appears to be a new entity.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d3206f9cb8e44d33bc57923911c80604",
            "input": "Severe steroid-induced glaucoma following intravitreal injection of triamcinolone acetonide.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e929050d961c491e906d00ef65047c2c",
            "input": "Methadone-induced myoclonus in advanced cancer.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5e5ef5142ba44bc5ae56b63ec3f347d6",
            "input": "The aim of this study was to describe the occurrence of acute coronary syndromes in 3 cases of rituximab infusions.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a2bd8a44489347679bbba4cc81c3453e",
            "input": "A young patient experienced marked sinus tachycardia while smoking marijuana and receiving therapeutic doses of nortriptyline.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9e6617722aef40a099707c2bb3481fed",
            "input": "Therefore, parenteral amiodarone was implicated as the cause of acute hepatitis in this patient.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3114534b0081464a9d8630c9622da92e",
            "input": "Transtentorial herniation caused by an intracranial mass lesion following high-dose methotrexate.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-7a5f60cb78b341e7b8694506b71caf22",
            "input": "Intracranial haemorrhage from a meningioma in a patient receiving aspirin prophylaxis: a case report.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-369630ca3f694936aed3dae6ceaf43a8",
            "input": "One patient who received clindamycin had liver biopsy findings of marked cholestasis, portal inflammation, bile duct injury and bile duct paucity (ductopenia).",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1455b71054a24da5858216050a0e30d2",
            "input": "Posterior reversible encephalopathy syndrome associated with methotrexate neurotoxicity: conventional magnetic resonance and diffusion-weighted imaging findings.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2a15d2d1420147728ad0510f1af2862c",
            "input": "We describe a 74-year-old man with rheumatoid arthritis (RA) who developed syndrome of inappropriate secretion of antidiuretic hormone (SIADH) 1.5 months after commencement of mizoribin prescription when his arthritis was improved.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e6294a01ad1b46c6aac986898f51012b",
            "input": "A 35-year-old female with borderline lepromatous (BL) leprosy who suffered from dapsone-induced erythroderma is reported.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-8d828252bc1c49b5a27ebabdaaa7c042",
            "input": "A 64 year old woman with previous history of coronary stenting five days before was admitted in our institution for intracranial bleeding while receiving aspirin and clopidogrel.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e2961febb91f4d5584f9e45c31998431",
            "input": "A patient that received methadone for cancer-associated pain developed myoclonus as a side effect.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-fe50da14c98546c28e49dd71f002c8c6",
            "input": "The present study describes a patient who had unusual weight fluctuation under corticosteroid and psychotropic treatment such as mianserin and aripiprazole.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-75a04b773cc34e5591a3f5ac7a70216c",
            "input": "Typical symptoms of active CD occurred 11, 12, and 26 months after start of etanercept therapy, respectively.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-af27d5142e5d4656b38ff9f473376bef",
            "input": "We attribute the clinical and radiographic findings to cytotoxic edema secondary to intrathecal methotrexate.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-54fc3cb42de24bd281d05e466873f519",
            "input": "Several case reports of aplastic anemia with use of acetazolamide, and two cases with use of methazolamide, have appeared in the literature.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-215dd8341fe14c81ae701f578546811d",
            "input": "A 37-year-old woman with relapsing invasive vertebral aspergillosis received intravenous VRC and developed angio-oedema 10 days after starting therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-88b97a95f92241f893bb8c034ccc8862",
            "input": "The case histories are presented of two patients who developed lung disease associated with the use of nitrofurantoin with histological features of bronchiolitis obliterans organising pneumonia (BOOP), a rare but recognised form of drug induced injury.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-bb95fd193b57491396ea0749dd4b4be8",
            "input": "Acute myeloid leukemia and lung cancer occurring in a chronic lymphocytic leukemia patient treated with fludarabine and autologous peripheral blood stem-cell transplantation.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-fc69c0a5e6af4308910789f2e6d16daa",
            "input": "Although various manifestations of pentamidine-induced cardiotoxicity have been reported, to our knowledge, second-degree heart block associated with this agent has not been described.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d6b8b449d3cf424eb781bbd5569d7e38",
            "input": "We report a case of hyperpigmentation due to bleomycin treatment in a patient with acquired immune deficiency syndrome (AIDS).",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-bbfdc8b36acd4e12a509abb4ef4944b7",
            "input": "PATIENTS: Three patients developed a reproductive endocrine disorder during treatment with valproate.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a440a582212442c2a72cba31ddd2a3e2",
            "input": "OBJECTIVE: To report the first five cases of amphotericin B overdose with secondary cardiac complications in a pediatric population.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-bb7ac59dd70a45df818e7c355874a29d",
            "input": "Patients receiving amifostine who develop only fever should be evaluated for an adverse drug reaction, as well as for sepsis and fevers of neutropenia, and it may be necessary to discontinue the drug.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f8fc9dc233024ee69f35bbd0517bcf51",
            "input": "Ethambutol toxicity manifesting as acute onset psychosis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d4b89e89098545698812cc7d1e832033",
            "input": "Can magnesium sulfate therapy impact lactogenesis?",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ab8b858a2ba046299ec6cf5c4d15e6df",
            "input": "Perinatal vasoconstrictive renal insufficiency associated with maternal nimesulide use.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-24665f152c5849a6a4a4bf9b77411f82",
            "input": "OBJECTIVE: To report a case of serotonin syndrome associated with interaction between fentanyl and citalopram, as evidenced by medication history, clinical features and reversal following discontinuation of fentanyl.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-bd2999175dd9458ea8829c45f61bc3aa",
            "input": "Antibiotic-associated colitis (pseudomembranous colitis) developed in four patients with spinal cord injury and taking oral trimethoprim-sulfamethoxazole.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0e5a1f331c7c4ef2af873d218d19d13f",
            "input": "In addition, there is a report on prolonged ECT seizure related to ciprofloxacin, which has an epileptogenic property with a similar action to beta-lactam antibiotics.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6617bd1e2a914f5b863760bcf4a34b48",
            "input": "Captopril-induced acute reversible renal failure.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-98815326b094478da0a984056660fe0f",
            "input": "These multiple overlapping factors probably lead to rhabdomyolysis in a minority of patients receiving vasopressin infusion.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-386399433e874a6b8c25dd950e1d8058",
            "input": "Baclofen withdrawal syndrome resulting from underdosing of oral baclofen should be considered as a potential source of prolonged fever in the intensive care unit.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d9f4c7adb95e4a17ab0218c63fd9d312",
            "input": "Disseminated tuberculous lesions post intravesical BCG therapy are rare but need to be identified and treated quickly.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-59111f54ef5e4da99ff498f6e8daafbe",
            "input": "Acute endophthalmitis following intravitreal bevacizumab (Avastin) injection.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1af0cb08640a490eacfcb4fb9547afb7",
            "input": "Cardiac toxicity related to BCNU has not been described well.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-37d18d6483ed40faab2f3b30d0e5fd36",
            "input": "To our knowledge, this case is the first published report of levofloxacin-induced TEN.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2bd8a3e54b264d72a0aeebb453c2a4b0",
            "input": "Exacerbation of anthracycline-induced early chronic cardiomyopathy with ATRA: role of B-type natriuretic peptide as an indicator of cardiac dysfunction.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-daf789ff296f475e8a02489deb0150e9",
            "input": "The occurrence of severe AIHA in CLL patients treated with fludarabine has been reported by several authors.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2cc25fb5a7334880b9b8c0a8a72f760b",
            "input": "RESULTS: Replacing valproate with lamotrigine resulted in a decrease in serum testosterone concentrations in all 3 women.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-40f42dd58c6544d29770ab5d69c66d59",
            "input": "A case of liver damage following treatment with Danazol for fibrocystic breast disease is reported.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-25667756bc674b349cdda8fed1db4dab",
            "input": "Central nervous system toxicity associated with meperidine use in hepatic disease.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-199981c84a2a4bbda5fd2c2100335f0d",
            "input": "Sweet's syndrome associated with sargramostim (granulocyte-macrophage colony stimulating factor) treatment.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c505ac72f3ec405688f6f8372264e6b2",
            "input": "OBJECTIVE: To our knowledge, this is the first published case report of an adolescent girl with a mitochondrial disorder and depression who displayed both new-onset psychotic and increased mood symptoms during treatment with risperidone.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-586789b621f14367ba333dcc42f3572a",
            "input": "In conclusion, this case strongly suggests that gliclazide can induce acute icteric liver necro-inflammation which may be misdiagnosed clinically as acute viral hepatitis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ab40253fe7bb495f8f71cf1faee7670e",
            "input": "The toxic effects of methotrexate included elevated liver transaminases (3/4), nausea (2/4), abdominal pain (2/4), bone pain (2/4), mild neutropenia (1/4), and mild pruritus (1/4).",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2bf6be97e7084b1d931a000d0c842873",
            "input": "Methotrexate-induced liver cirrhosis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-912e2b56d6e24566805b73554d3f5763",
            "input": "OBJECTIVE: To report the safe use of fluorouracil in a patient with breast cancer who had allergic reactions to capecitabine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2cfeb35ff4894e5587a5b29c29f9f1b1",
            "input": "Bowel perforation associated with intraperitoneal chromic phosphate instillation.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a3dc237717c94fabbdad97de8a1c8c60",
            "input": "Mefloquine-associated hypoglycaemia in a cachectic AIDS patient.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-320c0c3574134c7987e3b93d28034130",
            "input": "Due to the severity of the rash, temozolomide was permanently discontinued.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-755caf4b49da416ea4969aca2ca9c126",
            "input": "Type I second-degree AV block (Mobitz type I, Wenckebach AV block) during ritodrine therapy for preterm labor.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4a5e1281fb4a41a0b427c71d4e090e2b",
            "input": "Rebound hyperglycemia following overdosing of insulin in cats with diabetes mellitus.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-77317140b4e34acd9b00386e158b096d",
            "input": "She died within six weeks of developing congestive heart failure coupled with liver failure due to haemosiderosis despite regular use of desferrioxamine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2177c7b093a64b62b010f39a60ea598b",
            "input": "DIAGNOSIS: Interferon alpha-2b-induced cardiomyopathy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-43fc66d4e6974738ae49941cf39d968e",
            "input": "Anaphylaxis from isoniazid is a possible side effect to this commonly prescribed antibiotic.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9b99d4424f3c4a0a8e735ca84f229eff",
            "input": "Arterial hypertension associated with topical ocular use of phenylephrine in dogs.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-603cadb19ef54f289108cbf7d153ef5e",
            "input": "ARDS is rarely associated with rituximab infusion for lympho-proliferative disorders, but it should be considered by those administering rituximab, especially when a patient develops severe pulmonary symptoms soon after infusion.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ce0c25d974824e25b5ddde59d583054e",
            "input": "Severe autoimmune hemolytic anemia following rituximab therapy in a patient with a lymphoproliferative disorder.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0a2ca9f1778d4eb381fa0538aedabbfd",
            "input": "OBJECTIVE: To report a case of neuroleptic malignant syndrome (NMS) associated with fluphenazine in a schizophrenic patient and review the literature related to this condition.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2937688845f449119f695e0ccb32b45b",
            "input": "However, there remain questions concerning whether these drugs, especially methimazole (MMI), may be associated with aplasia cutis congenita (ACC) and how best to avoid impairment of fetal thyroid function during their use.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-03ef361f66014bdd9f41a04fd5edff67",
            "input": "PATIENTS: Two patients, ages 40 and 51 years, undergoing treatment with interferon alfa for malignant neoplasms experienced sudden bilateral, sequential visual loss with disc-related field defects and segmental optic disc edema.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9600a12a162142528a52547387c00c7b",
            "input": "In case no. 2, the pathogenic mechanism seemed to be persistent light reaction preceded by systemic photoallergy, as he had taken mequitazine for 6 months, and there were strong positive photopatch test results with immediate erythema reaction, cross-reaction to promethazine, decreased MED to both UVA and UVB, and persistence of the photosensitivity over a 3-year follow-up period after discontinuation of the mequitazine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a84c9ef96fbc45e4b97c1852c4d2f930",
            "input": "Despite the known pulmonary side effects of nitrofurantoin, there is no report of this toxicity occurring in pregnant patients.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-901444e865f748338eb2036925d0ccd9",
            "input": "CONCLUSIONS: This study confirmed that in most patients MTX-induced liver cirrhosis is not aggressive.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-44565e12335849648b62bde969325353",
            "input": "Fatal interstitial lung disease after erlotinib administration in a patient with radiation fibrosis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b4148dbeba9e4ac8a85160ba124f0a6b",
            "input": "A 17-year-old boy with refractory psoriatic arthritis and alpha-1 antitrypsin deficiency who developed a syringotropic hypersensitivity reaction after 9 months of therapy with infliximab and leflunomide is described.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-aafe64d43b5a408184f250c40f85673e",
            "input": "However, prolongation of 5-FU half-life and an increase in INR have been reported with the concurrent use of 5-FU and warfarin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-8c8d6271f1e9437fb3975d1525f5bc69",
            "input": "Carbamazepine toxicity following Oxybutynin and Dantrolene administration: a case report.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d04ba39699a340c7969aaf391f1cc5c1",
            "input": "Seizures associated with fluoxetine therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-8cd2e720c0be4301bd6c50b2927150de",
            "input": "Thiopurine methyltransferase deficiency occurs at a frequency of one in 300 and is associated with profound myelosuppression after a short course of azathioprine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b2b2e231553f472ea5aab7618c992a69",
            "input": "This report describes a case of bilateral ptosis induced by chloroquine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-985c455cd3094c9e8c1d624792bd1638",
            "input": "However, dermatologists should be cautious about a photosensitivity reaction induced by mequitazine or other phenothiazine-derivative drugs.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5c6b88f9383340b7a3d3bdefa670325f",
            "input": "We describe a relatively healthy, 9-year-old boy who developed a CA-MRSA skin and soft tissue infection and was treated with TMP-SMX.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-10fda6bfd47c463b994431f9e2535df3",
            "input": "A 73 year-old patient with Wolff-Parkinson-White syndrome and paroxysmic supraventricular tachycardia developed an acute reversible encephalopathy within 15 days of initiation of flecainide.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5e94ddcfc8654535b6805f422c901390",
            "input": "Sulfasalazine-induced lung disorder is an extremely rare entity which must be considered in all ulcerative colitis patients while on sulfasalazine therapy, despite the absence of pulmonary symptomatology.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-58d3be99bbeb4e3182fde35adb887856",
            "input": "In all cases, drugs in addition to quetiapine were detected, but in cases #1 and #2, the cause of death was considered to be a quetiapine overdose and the other drugs were not considered to be contributory.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c7280f73c3c1412b9ce9f37f7be8647c",
            "input": "This eruption appears to be a distinct cutaneous toxicity of PLD.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b3199cc1680d4fd48b870d8102dcd76c",
            "input": "Capecitabine-induced headache responding to diltiazem.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-49ff9258d8a842048f30ef83a16f6999",
            "input": "Syncope induced by propranolol in hypertrophic cardiomyopathy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-94e81117896440059172050421bc361d",
            "input": "Due to the increasing use of TMP-SMX in children, clinicians should be aware of this potentially life-threatening, immunemediated hypersensitivity reaction.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1fbbd406ccc64cb5b236a80ea1254339",
            "input": "In all cases, seizures were controlled by withdrawal of phenytoin and reduction of drug levels.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-867e7441ecf743829aa5134eb4e032f9",
            "input": "The development of erythroid leukemia plus carcinoma in these two men suggests mutagenic change secondary to cyclophosphamide therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2514a70127914a749b096dd7dd1a786a",
            "input": "Possible linkage of amprenavir with intracranial bleeding in an HIV-infected hemophiliac.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-099670887c274239945feb1f95a9563e",
            "input": "OBJECTIVE: To describe a patient with asymptomatic bronchial asthma and hypertension who developed an acute asthma attack after receiving sustained-release verapamil.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-95be38bcb13f4273b359bbd1dd1b99fa",
            "input": "To our knowledge, this is the first report of insulin-induced lipohypertrophy with detailed histological examinations.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9f481b7ac759453f9fc297a754f01aeb",
            "input": "Aripiprazole-induced hiccups: a case report.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a8ac77c917ee48c9ba754787d5f7ef61",
            "input": "Diagnosis of sclerosing glomerulonephritis occurred in this patient during anastrozole use, suggesting a newly defined side effect of anastrozole.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-99ca9bfe63bf48f0a502f5f6c02d9642",
            "input": "Reversal of gold-induced neutropenia with granulocyte colony-stimulating factor (G-CSF).",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b630d9ea70734560837e658d15e5fbdd",
            "input": "We report a case of intrathecal methotrexate neurotoxicity manifesting as left arm weakness and aphasia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-28adb15412734c12b077dd4744961807",
            "input": "This regimen could prove useful for other patients who develop hypersensitivity reactions to carboplatin and allow therapy to continue.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-924afafad6a74efc9856154eccfa8634",
            "input": "A case of severe aplastic anemia secondary to treatment with lenalidomide for multiple myeloma.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-8e8fb3eb38dd40fb81c9e347ddbe81e3",
            "input": "A case of SIADH induced by mizoribin administration.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6f911dd1febc4c26a21cfc02b0058573",
            "input": "We report a case of torsade de pointes following a single oral dose of amiodarone (1400 mg or 30 mg kg-1) administered after short intravenous loading for prevention of paroxysmal atrial flutter.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-aacf921dccdf4df99c852c763f417bfc",
            "input": "Hashimoto's disease during interferon-alpha therapy in a patient with pre-treatment negative anti-thyroid autoantibodies and with the specific genetic susceptibility to the thyroid disease.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-bfc1c884a43642c58715d96c4a9fb21d",
            "input": "While undergoing treatment with albendazole, he developed worsening diarrhea with abdominal pain and fever.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-35877504054647efb1057bcc5a1b351a",
            "input": "Early overanticoagulation with acenocoumarol due to a genetic polymorphism of cytochrome P450 CYP2C9.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-dd6854d602bd4aae8ffaaa0d444de079",
            "input": "The patient suffered a life-threatening anaphylactoid reaction to amifostine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-066ab7cc358e4483bb3e2179891175d3",
            "input": "METHODS: A 55-year-old woman became stuporous after overdose with lamotrigine (LTG) and valproic acid (VPA) tablets.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ce5e64129a264ab4a309854b8833795f",
            "input": "CASE SUMMARY: A 58-year-old white woman developed fulminant liver failure while being treated with the macrolide antibiotic clarithromycin for pneumonia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4792cad636014843a86d837371e5c734",
            "input": "Acute renal failure during lisinopril and losartan therapy for proteinuria.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f0b32cb464954924976de391c92f3ff4",
            "input": "The main side-effects of Lp-TAE combined with HT were low-grade fever, localized pain, myelo-suppression and liver dysfunction, but these were transient and eventually disappeared.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c4cdebfc20934db3ba497ff167bbe1cf",
            "input": "Pulmonary toxicity with mefloquine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6e9f6d08d165418fa396e78115e610d1",
            "input": "A 64-year-old man presented with proteinuria during postoperative interferon (IFN)-beta therapy against malignant melanoma.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-07d9676d64a04ddd9cb675b7751c2071",
            "input": "Ramipril-induced cutaneous vasculitis is particularly rare and our case was atypical because the patient had tolerated lisinopril before.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-279ba8c0e297447185e876abddf39219",
            "input": "Myoclonus and seizures in a patient with parkinsonism: induction by levodopa and its confirmation on SEPs.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5a0d918432a04a03b70c955936bc8c61",
            "input": "We report a 44-year-old woman with t-MDS (refractory anemia with excess blasts) following treatment of recurrent anaplastic astrocytoma with temozolomide (TMZ).",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-fb840efb083b45fca3b7ddd9c8074fa0",
            "input": "The use of methotrexate (MTX) has been contraindicated for treatment of severe psoriasis in HIV infection on the basis of six previously reported cases in which MTX appeared to potentiate opportunistic infections and accelerate HIV disease.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c2ea5a48f583450daec415e945cb349b",
            "input": "Amiodarone was discontinued, and thyrotoxicosis gradually abated.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-7046acf640604e24931ed24f5cc5bbbb",
            "input": "We report a case of a 60-year-old woman affected by squamous lung carcinoma, who developed paroxysmal supraventricular tachycardia during cisplatin and etoposide combination chemotherapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2748cbf927194efc82e5ee54cfccac40",
            "input": "BACKGROUND: Gemcitabine has mild renal toxicity, but cases of gemcitabine-associated hemolytic-uremic syndrome (HUS) have been reported.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c31f418478844dcbabc200bf73eaa8d8",
            "input": "Salicylate-induced hepatotoxicity is reviewed.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3bd3145a12c74cb5a8b9ffc9bb8450c0",
            "input": "Acute erythroid leukemia after cyclophosphamide therapy for multiple myeloma: report of two cases.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2bc482985cb446eaa0bb20c2499f8eae",
            "input": "Probable early acute hepatitis with parenteral amiodarone.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9a08d77b89254a8280c51a7918cea523",
            "input": "Acute renal failure in a child associated with acyclovir.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-836883448f7447669e312c2df5f9088f",
            "input": "We describe a case of prolonged terbinafine-induced cholestatic liver disease.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b5c95da052684f189b3588b0b2f74ca4",
            "input": "Recurrent hyponatremia associated with citalopram and mirtazapine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4544e176ff5c44ecb73f5fa48a4d69ce",
            "input": "Syndrome of inappropriate secretion of ADH (SIADH) following cisplatin administration in a pulmonary adenocarcinoma patient with a malignant pleural effusion.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-daf018e42ae0409caa0e6f580296341b",
            "input": "Itraconazole-related increased vincristine neurotoxicity: case report and review of literature.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-017df6a7b7d840dd9b0afd2bcfc2e362",
            "input": "In this case senna was likely the cause of a subacute cholestatic hepatitis exemplifying again the potential role of herbal related liver injury.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1658b02c49f24369a2be0d5b5532e323",
            "input": "We conclude that while thrombocytopenia and schistocytosis can be seen in quinine-associated TTP/HUS, the pathophysiology seems to be distinct from that seen in most cases of idiopathic TTP (i.e., severely decreased ADAMTS13 with an inhibitor).",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-66c1f2a5a258454db1cca4d32b8caba1",
            "input": "We experienced 2 cases of mequitazine-induced photosensitivity reaction in patients who took mequitazine for their dermatologic problems.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-75dbd38916d345e6a3c4c6c72212a4fd",
            "input": "Anti-tuberculous drugs had been stopped on the 2nd day of therapy due to development of optic neuritis secondary to ethambutol administration at another hospital.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9e3ceab3bdb944cd9c25a59248eed960",
            "input": "METHODS/RESULTS: This paper presents a new case of rifabutin uveitis and a review of the various published reports to date.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-149948cc8365404f99ba27bfbbdac2b3",
            "input": "Isoniazid causing breast tissue enlargement has been very rarely reported.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-762631cd2a5c4a1d9252497e642b8474",
            "input": "We report on three patients who developed acute liver damage during therapy with itraconazole, and in whom liver biopsy specimens were obtained.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-814f55e4211142b0bcf33a4a050fa238",
            "input": "Although moderate myelosuppression is not uncommonly seen in patients treated with lenalidomide, aplastic anemia has not previously been reported to be associated with this agent.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-8c9e1c5111a644cdb3f4cb94a63ab26a",
            "input": "Agranulocytosis is a rare adverse effect associated with prolonged vancomycin therapy, and is potentially serious, especially in end stage renal disease (ESRD) patients.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b97df301b79c4e83a2fe16e509270a70",
            "input": "Nodular scleritis following alendronate therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-22bb9882fd7d42f3aded66bb5f886c6e",
            "input": "Syringotropic hypersensitivity reaction associated with infliximab and leflunomide combination therapy in a child with psoriatic arthritis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-cca7a166758045b18b190df96907ee68",
            "input": "Physicians should be aware that indinavir nephrolithiasis may cause papillary necrosis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3efbcf51aa6f4aada5520f75143e4391",
            "input": "Many clinicians appear to be concerned about the potential hepatotoxicity of the opiate antagonist naltrexone (NTX) and this may be one reason why it is not used more widely in treating both heroin and alcohol abusers.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9741819f36ac4d4a9a0ee6351b285ab1",
            "input": "Nonspecific but significant abnormalities have been described in the infants of women treated with disulfiram in the first trimester of their pregnancies.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1114a84119fa4e6ba57996c6ccfcfa65",
            "input": "Such anagen effluvium with lichenoid eruption following INH therapy has not been observed previously.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ce8748b4cc864e1e8de032dd65b58fcd",
            "input": "It should be emphasized that the recurrence of nephrotic syndrome was observed after the following chemotherapy, including M-CSF, whereas the bone marrow still remained completely remitted.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-487373d3fed64930b4a500bf66ac1b78",
            "input": "Tumor-volume increase at beginning of primary treatment with topical interferon alpha 2-beta in a case of conjunctiva-cornea intraepithelial neoplasia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d8ffccbe66374cd1b0294d66af8b6412",
            "input": "Isoniazid-induced anaphylaxis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2214ac2338894f42b985d59e57aa33fa",
            "input": "Since elevated cortisol levels in Cushing's disease poses a threat for pancreatitis, there is a possibility that patients with Cushing's disease might be more prone to acute pancreatitis following propofol administration.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-df8751263ad9403889416dc07560b686",
            "input": "Treatment of lithium-induced diabetes insipidus with amiloride.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4f3e755202a04ebc964999e10df00dcd",
            "input": "Hence, hyperthyroidism induced by IFN-alpha could correspond to the first phase of silent thyroiditis, to Graves' disease or to the succession of both.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-adc7961428e740099262536f3a16498c",
            "input": "Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-bbd6b67123e8404e83a3dbe4a212ccc4",
            "input": "Gemcitabine-related radiation recall preferentially involves internal tissue and organs.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5464beeea47e45f3bbce4b670d9b9005",
            "input": "Generalized pustular psoriasis precipitated by trazodone in the treatment of depression.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c57d6748ab6d4821b7c29e2bab3be72b",
            "input": "We report on a child with fatal valproate-related hepatotoxic effects despite this supplementation.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-7d431f84817246dd854cde6f8e823243",
            "input": "Retrospectively, bucillamine was believed to be the cause of the giant hypertrophy because of its structural similarity to D-penicillamine, which was the subject of an abundance of reports of mammary hyperplasia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-98ff38c08e6a415a88101f0cac69b0cd",
            "input": "We report a case of a patient with rheumatoid arthritis treated with low-dose methotrexate (15 mg/week) who developed infection with both M. tuberculosis and M. chelonae after the revision of a prosthetic hip.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-747e1b3e56384cabae48c85b0ae255a6",
            "input": "The authors conclude that among patients taking high doses of oral niacin only those who experience visual symptoms need to be ophthalmologically evaluated.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3c94fbfe22e243b1a0788059725b223c",
            "input": "Retinopathy in hepatitis C patients due to combination therapy with pegylated interferon and ribavirin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-7e4965e73263403d9b096cee7898a8ba",
            "input": "Protamine-induced fatal anaphylaxis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5372cf22bd42474bb73e7dcc49cf20b0",
            "input": "Gynaecomastia is a rarely reported adverse drug reaction due to isoniazid therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1918fa4de9754558a41c5abc6adc386d",
            "input": "We report the case of a patient with multiple myeloma who developed acute life-threatening water intoxication following treatment with oral indomethacin and low dose intravenous cyclophosphamide.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-89ad26ee8b08458db5d995316747d73b",
            "input": "DISCUSSION: Anaphylactoid reactions have been described previously with cisplatin administration.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6b195798fe084011bc3230e76400f40e",
            "input": "Lethal anuria complicating high dose ifosfamide chemotherapy in a breast cancer patient with an impaired renal function.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-58e6beda057e456a8770bd08462f9820",
            "input": "In patients with cirrhosis, the metabolism of meperidine is decreased, leading to accumulation of the parent drug and possible CNS depressive effects similar to hepatic encephalopathy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-43667dfbf286452fa7494f22e9e067aa",
            "input": "Physicians should be aware of the potentially lethal side effects of dapsone.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-10dff71a558a4812923f24859940d0d8",
            "input": "To our knowledge, no prior cases of penicillamine-induced TTP in RA have been reported.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e9033f7376194bf49d2265fb8fd53aac",
            "input": "We present the cases of two female patients diagnosed with relapsing-remitting multiple sclerosis (RRMS) who developed inflammatory musculoskeletal manifestations, following IFN-beta therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b502edabc2284a338cc9a40503e56136",
            "input": "We presented a patient with status asthmaticus treated with a combination of theophylline and prednisone who developed a perforated gastric ulcer.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0389382b81e44dcaabe61a021b31bcbb",
            "input": "The first known report of quetiapine exacerbating OCS in a 43-year-old man with obsessive-compulsive disorder (OCD), trichotillomania, delusional disorder and bipolar II disorder is presented.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5ad552ebed0c452e8cc370f6e903d100",
            "input": "CONCLUSIONS: Symptoms and pathologic changes of colitis are associated with exposure to rofecoxib.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-05610a23696748a3891e80380bf698b2",
            "input": "Three of these patients had convulsions attributed to imipenem/cilastatin; 3.6% of the patients had seizure, or 2% of imipenem/cilastatin administrations was followed by a seizure attack.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-741be5fa1f3e434cb35ff25302002e26",
            "input": "A 51-yr-old nonsmoking male patient without any history of previous allergies, asthma, hay fever, or urticaria developed attacks of asthma when captopril was added to the nadolol and dyazide treatment for his high blood pressure.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-787424f45e7b4facb568d58f3f1ac888",
            "input": "The polycystic changes disappeared from the ovaries in 2 of the women after valproate therapy was discontinued, and the 2 women who had gained weight and developed amenorrhea while being treated with valproate lost weight and resumed menstruating after the change in medication.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6e2f2c04f46c4a6cb088cb3ce46bb93a",
            "input": "We present the first case of WES in an infant born to a mother taking haloperidol during her pregnancy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-8df346b648234f39b0843f48e6c07325",
            "input": "Oral 25-hydroxyvitain D3 in treatment of osteomalacia associated with ileal resection and cholestyramine therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-fa3ae6dc5b6d40669d3c70331774943c",
            "input": "We report three cases of IFN beta induced hepatitis in MS and discuss the pathology findings and possible mechanisms of drug-induced liver injury.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9b478491ed5c4185bdfb58bcfb549d37",
            "input": "Based on these findings, the patient was diagnosed with diabetes insipidus secondary to lithium therapy and was treated successfully with amiloride.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f9912bc6d3ca48549e4e0499950c57f3",
            "input": "Lichen planus and acne provoked by gold.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-576931ec30d24190a335d39ea6d6de74",
            "input": "He was started on digoxin, 0.25 mg daily, because of echocardiographically demonstrated left ventricular dilatation and functional impairment; he died of ventricular fibrillation 15 days later.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b27d21ad54964a0caeda040e1bffc1e1",
            "input": "In the absence of mucositis or diarrhea, severe dermatologic toxicity following a single low dose of the drug suggests an 'allergic' or acute hypersensitivity reaction to MTX in this patient.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d422df4537a44d74a7bbb20edad828b6",
            "input": "Benzocaine-induced methemoglobinemia has been reported in man, dogs, and cats.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-fba2196c246047e1b6651a5f36b767bb",
            "input": "A review of the literature showed no previous description of this pattern in benzodiazepine coma.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4d46afadd647430e9db1a9f106a420b3",
            "input": "A 62-year-old Indian with diabetic nephropathy controlled with metformin, developed miliary tuberculosis for which he was treated with rifampicin, isoniazid and ethambutol.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-60fab425b4b54984ae88241425ac109f",
            "input": "Sensorineural hearing loss due to quinine therapy for malaria has frequently been mentioned in the literature but has not been a subject of research during the last decades.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e24ec8fb6b234edba735fbb3a02c1dba",
            "input": "OBJECTIVE: To present a single case of zuclopenthixol-induced priapism and a literature review.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2ef363506e764a96bd4627394a837dec",
            "input": "MATERIALS AND METHODS: We present two cases of significant morbidity related to primary and secondary perforation of the bladder following two instillations of epirubicin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-49584220307d4940a7ca241142007de2",
            "input": "Intravenous azithromycin-induced ototoxicity.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-178709464b9f4a25b27a5ce2ca9a5660",
            "input": "In one child, a second course of carbamazepine resulted in a return of the dystonia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c6c42cd2a57f4875b7f8d5704ff654a7",
            "input": "CONCLUSION: This is, to our knowledge, the first report of severe myelopathy following accidental intrathecal administration of doxorubicin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-11d7ff4f204a4bf6a6f6231ec2bfe856",
            "input": "However, as the use of hepatitis B vaccination is growing, adverse side effects, including mental nerve neuropathy, should be observed with an increased frequency.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-39e7572975344eb19c4f69d9551afffb",
            "input": "Autoimmune thyroid disease is a common side-effect of interferon-alpha (IFN-alpha) treatment of viral hepatitis C.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e12ab59eae674017a3aa858c394ed800",
            "input": "An immediate hemolytic reaction induced by repeated administration of oxaliplatin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-8c307f44d2e948199fd793c5c4baccd7",
            "input": "Retinal abnormalities, including retinal hemorrhage and \"cotton-wool\" spots, often occur within the first 8 weeks in the course of interferon therapy in patients with chronic hepatitis C.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2b5acdff302846d2b8c7b6aca0f08f8d",
            "input": "Propoxyphene-induced wide QRS complex dysrhythmia responsive to sodium bicarbonate--a case report.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-33a51a33961241b48dd6c1c083b64f76",
            "input": "A case of polymyositis with dilated cardiomyopathy associated with interferon alpha treatment for hepatitis B.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-be14e55e48a2471e8869046411fe70cd",
            "input": "Except hypothyroidism after radioiodine treatment (euthyroid under substitutional therapy), she suffered from no other diseases.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3fac8398ebcc4b8491817399967deb23",
            "input": "The authors report 2 cases of renal damage associated with lithium carbonate treatment.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0d88b97796544c1c96cf34acf80ca89d",
            "input": "We describe two cases of sulfadiazine-induced crystalluria and renal failure in patients with acquired immunodeficiency syndrome, review the pertinent literature, and discuss the pathogenesis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-015d9007434c4b10b7804c2cef66178c",
            "input": "PURPOSE: We report an unusual paradoxical effect of brimonidine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d45fd373d45a41d38b35e0378a406737",
            "input": "Thrombocytosis under ciprofloxacin and tazobactam/piperacillin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-dcaadfedb0ed45f2b859aa723f362a4a",
            "input": "A 64 year old man with recurrent metastatic squamous cell carcinoma of the head and neck developed severe skin rash and bone marrow aplasia 4 and 7 days, respectively, following a single dose of 40 mg/m2 methotrexate (MTX).",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ea8362ef779649c08b47e72486d7cb0e",
            "input": "We present a case of an elderly woman with a pre-existing history of ischaemic heart disease, who was treated with venlafaxine, and developed acute myocardial ischaemia within the first week of treatment.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-aae6eac119c449a19b8345637a220027",
            "input": "One week after the initial-dose of adalimumab (160 mg), which was initiated due to an acute exacerbation of Crohn's disease, the patient developed a fulminant cardiomyopathy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a72bb02cf0bc4636bd7db18eb9580a70",
            "input": "Phenobarbital hepatotoxicity in an 8-month-old infant.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-bde1f5a7e8e5484ea3ee1db5e7e02618",
            "input": "This represents the first report of nonconvulsive status epilepticus induced by ifosfamide.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-959dc2a448da45dc8c056a179ed05086",
            "input": "The occurrence of acute hepatitis is best known for ketoconazole.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-318d36ac59ba4141aee52f2c83b5ca3e",
            "input": "A twelve year-old-girl with idiopathic partial epilepsy with secondary generalization, developed acute psychosis 10 days after the administration of levetiracetam.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b754b799e5ad4d8a8b2b4850222606e3",
            "input": "ARDS has been associated with the administration of other monoclonal antibodies, such as infliximab, gemtuzumab ozogamicin, and OKT3 and is believed to be directly mediated by release of proinflammatory cytokines.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0bb5972419d2488a978fefce29262ec4",
            "input": "The authors suggest that fluoxetine-induced akathisia may be caused by serotonergically mediated inhibition of dopaminergic neurotransmission and that the pathophysiology of fluoxetine-induced akathisia and tricyclic antidepressant-induced \"jitteriness\" may be identical.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-607b2068ac074da39a402b4d5632c27f",
            "input": "Here we report ramipril-induced cutaneous vasculitis in a patient who required steroid therapy to control it.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b905983717514704b02ff8b06f95f229",
            "input": "Tiagabine overdose causes an unusual array of neurological symptoms, many similar to reported adverse effects during therapeutic use.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3f8ddf200d6b4b3abd11c84ea8197408",
            "input": "Scleroderma in association with the use of bleomycin: a report of 3 cases.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-66245a4545ff47ae94df4740c4c446cf",
            "input": "The increased libido disappeared after fluvoxamine was discontinued.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b4cc13a834334876aded9aac46d1c534",
            "input": "Renal hypophosphatemia in this patient was caused by the erroneous intake of 1 g doxycycline.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5ec9de7c5da146a384a40e565b61e56d",
            "input": "We present the management of agranulocytosis and neutropenic sepsis secondary to carbimazole with recombinant human granulocyte colony stimulating factor (G-CSF).",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e2987b154bf74f4fa7c2d18394f6086a",
            "input": "Acute severe intoxication with carbamazepine is associated with seizures, coma and respiratory depression.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-89e5a4ed523141b692d6adc51ff0cb00",
            "input": "Complete remission of the nephrosis occurred after discontinuation of hydroxychloroquine therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-54ad76e0970f46ec8cf66feeeb32ab8c",
            "input": "We describe a patient with transitional cell carcinoma of the renal pelvis who developed respiratory dysfunction and an abnormal chest x-ray with diffuse interstitial opacities while on chemotherapy with piritrexim, a methotrexate analog.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b83edfb4dd0743638097e762dbb7c328",
            "input": "Intrathecal methotrexate-induced acute cerebellar syndrome.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-abba7cb6a88f4098862b7d13a30a2e39",
            "input": "Discontinuation of simvastatin and cyclosporine resulted in resolution of rhabdomyolysis and normalization of renal function.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f0c3621303e44879a95eacb223bb8469",
            "input": "When the disease recurred conventional amphotericin B was used again, but had to be stopped because of severe side effects.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-85193eaf24c04d3c8e088d10d55ee990",
            "input": "Flare of Kaposi's sarcoma (KS) is well described in immunosuppressed patients treated with corticosteroids and rituximab, but has not yet been reported during treatment with imatinib.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a25b4fa471834478aff55d5076e1f6a5",
            "input": "INTRODUCTION: Although gefitinib used for the treatment of non-small-cell lung cancer is a well-known cause of interstitial lung disease (ILD), few case reports on erlotinib-induced ILD have been issued.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9d6d7a8f7f734b5c8200c80793f679ba",
            "input": "We present a case of respiratory failure occurring in a woman at 16 weeks' gestation who was being treated with nitrofurantoin for a urinary tract infection.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4260a51a379e48b394eba1f6f87af5ee",
            "input": "Because etoposide-induced pulmonary toxicity is an uncommon but serious adverse event, clinicians must be vigilant about the possibility of it, so that the optimal treatment can start as soon as possible.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d35973cee58f47c7b3c67ea34c47b540",
            "input": "The patient described in this paper was a 78-year-old diabetic man who developed oral lesions of PV following institution of glibenclamide therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-cc09f2fb87d043e5a8e6b699f294527a",
            "input": "Nonsustained polymorphous ventricular tachycardia during amiodarone therapy for atrial fibrillation complicating cardiomyopathy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f7590fe681424848a447ba9a7e671305",
            "input": "This compound, used by adults in the child's home, had caused accidental theophylline poisoning, mimicking diabetic ketoacidosis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3178c506500e4d2fb88834c75c9e7b58",
            "input": "Lithium-associated transient thyrotoxicosis in 4 Chinese women with autoimmune thyroiditis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-30b14c470ee44a6f8ea567861b11a538",
            "input": "Rapid identification of speech loss linked to FK506 may be important because reduction or cessation of the drug may be associated with reverse of speech loss.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-fc980d60305849c481652f97c12561f3",
            "input": "Reversible findings of restricted diffusion in 5-fluorouracil neurotoxicity.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-55f7306763114aaa937df64e9865239a",
            "input": "Carbamazepine induced right bundle branch block in a Greenlandic patient.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3c1b47a8501d48f39cb203e2c731c70f",
            "input": "However, there are few reports in the literature of ampicillin as a cause of acute interstitial nephritis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1f8409ece55349a9bbf215573aca6b9b",
            "input": "Reversible corneal keratinization following trabeculectomy and treatment with 5-fluorouracil.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-24d1a382659943919845f52a2e400ee0",
            "input": "On the fifth day after administration of a high dose of ARA-C (2 g/m2 intravenously every 12 hours), she developed bullous lesions on the hands and soles that disseminated, evolving to necrosis, sepsis, and death on the 22nd day.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5004e8f7801a4bd2a0b4fbb1f5ba692e",
            "input": "Argatroban for heparin-induced thrombocytopenia in hepato-renal failure and CVVHD.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0343be8e3b1b445287f0da654c2d9f39",
            "input": "We describe a case of advanced ovarian carcinoma who developed difficulty walking because of marked pain in the lower extremities and loss of proprioception 25 days after treatment with weekly taxol (80 mg/m(2)x3).",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0e9a1467d4e24dfb937156e26eba6cfc",
            "input": "He became hyperkalemic on rechallenge with timolol and normokalemic following its withdrawal.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c697f69ea79a43bbbfa4155e9983e7a2",
            "input": "When thrombosis develops during heparin treatment, it is important to suspect HITTs and to assay for the associated antibodies, regardless of the actual platelet count.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-87183e57971b4f0ab525bde9468309c7",
            "input": "A 31-year-old female developed multiple episodes of grand mal seizures after combination chemotherapy with cisplatin, vinblastine and bleomycin for germ cell ovarian cancer stage Ic.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-8cd2851cdd6f435dbc1f727237b7ebc0",
            "input": "Primary CNS lymphoma complicating treatment of myasthenia gravis with mycophenolate mofetil.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-539b6bb12d3f497598b9f7b8ab20d8cd",
            "input": "Pemphigus vulgaris precipitated by glibenclamide therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-63c4eec6bb344293a8a44998eaad1a66",
            "input": "Induction of systemic lupus erythematosus by interferon-gamma in a patient with rheumatoid arthritis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3ad3ac306bc7473490bc7a1bab36e3e2",
            "input": "CONCLUSIONS: Among the many presentations of ifosfamide neurotoxicity, clinicians should consider NCSE as a possible explanation for changes in consciousness in a patient receiving this agent.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5e596b1e09bf4499a3008395c47ad733",
            "input": "CASE: We present an 11-year old male with Budd-Chiari syndrome who experienced profound worsening of chronic aphthous ulcers after immunosuppressive therapy was changed from tacrolimus to sirolimus.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a480f917fb184d93a6d9bf543727563e",
            "input": "We report a case of acute generalized exanthematous pustulosis (AGEP) in a 50-year-old woman that was attributed to the ingestion of nimesulide.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-254c1c2014284f8e9ab0cc1fdda03c10",
            "input": "ARA-C is frequently associated with dermatologic toxicity, but this is only the second case of toxic epidermal necrolysis described in connection with this drug.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6f479c7840854ee5a11673e4f14ff130",
            "input": "Acne provoked by gold seems not to have been described elsewhere.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9577426312bf4c5584265eac14fd265d",
            "input": "Niflumic acid-induced skeletal fluorosis: iatrogenic disease or therapeutic perspective for osteoporosis?",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-80080e52390746e1b8b66c64faf74042",
            "input": "PURPOSE: To determine the cause of spontaneous choroidal hemorrhage in a 67-year-old man after a myocardial infarction and administration of tissue plasminogen activator.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a6e0fd7e6d124fb8abfb280c6920c406",
            "input": "Cicatricial entropion associated with chronic dipivefrin application.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-be497b45336749a283874351e3d736c6",
            "input": "Treatment with infliximab is known to produce an increase of autoantibodies (antinuclear antibodies, anti-double-stranded DNA), but not clinical disease.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-265918cb3fcd4e9d90373717f72c7979",
            "input": "Two patients with extrinsic asthma and coexistent insulin-dependent diabetes mellitus sustained an anaphylactoid reaction after the intravenous administration of 50% solution of dextrose.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0a8383ca67a545e98e3ce2563de4e7b6",
            "input": "Physicians should therefore be aware of its occurrence and carefully monitor serum levels of CPK, GOT and GPT during the treatment of diabetes insipidus with clofibrate, especially in patients with associated hypothyroidism, latent or overt, which possibly favors the development of myopathy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-61bb0266c9294f00a0840030f008148d",
            "input": "After receiving 3 doses of ifosfamide/mesna, she was found to be unresponsive.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-88600b4dde7e462badad5577db2cfbf2",
            "input": "Methotrexate-associated nephropathy is a rare complication in pediatric oncology, and a review of the literature suggests that exposure to nephrotoxic agents may be a significant but perhaps underrecognized risk factor for its development.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b664c8af7bb74221bf0e8f40e22db291",
            "input": "It has been reported that fluoroquinolone antimicrobials prolong the corrected QT interval but rarely cause torsade de pointes.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ed270464b9154c8584d29e439ae15447",
            "input": "Despite a postulated dopaminergic mechanism, there seems to have been only one previous report of amantadine's precipitating psychosis in a schizophrenic patient.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2ab1e83712644f6ca1f213df2536dfc1",
            "input": "This is the first report of a catatonic syndrome occurring in a patient receiving disulfiram treatment.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4b1aef419561444d96c4e9d04cdad662",
            "input": "In summary, we report herein the first case of SIADH believed to be an adverse effect of mizoribin, which may therefore needed to be added to the list of drugs which can induce SIADH.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-7e87bdef927743bd96105ce52ecc3ea6",
            "input": "Generalised cutaneous rash associated with ganciclovir therapy has rarely been reported in literature.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b58d5cd1b76d44db931fcf1568fda1f9",
            "input": "A 71-year-old man, who had a history of a previous bullous drug reaction to a sulfonamide, began receiving an ophthalmic preparation that contained sulfacetamide sodium.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e2b91e6e15bc404bb84ed39d840d255c",
            "input": "Paroxysmal supraventricular tachycardia during treatment with cisplatin and etoposide combination.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-aad0d28628f146538e52b65c7514518a",
            "input": "A 57-year-old woman with right bundle branch block +LPH and ventricular premature contractions developed complete heart block (CHB) following administration of disopyramide phosphate (Norpace).",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a950f013c79a45ca86e8df0211b4c3fa",
            "input": "Rifampin (RFP) increases hepatic microsomal enzyme activity, and there are case reports of RFP-induced hypothyroidism, all associated with Hashimoto's thyroiditis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-678777ffaf8e4f17a607dc53a409aaf8",
            "input": "Heparin-induced hyperkalemia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-bfbd351ba5fe4e02af6c756167cb4562",
            "input": "Interferon-induced psychosis as a \"psychiatric contraindication\" to hepatitis C treatment: a review and case-based discussion.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-598c1cf6d5d043f98e74d575198ba983",
            "input": "OBJECTIVE: The authors described a case of interferon-induced psychosis as a framework to review the literature and discuss the decision to pursue antiviral treatment in psychiatrically ill patients with hepatitis C.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0325f9c322934f508f0fb8ad58ab7fd3",
            "input": "Cutaneous vasculitis secondary to ramipril.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-55368d518b2d4875aa94f77411ed8550",
            "input": "Case 2, a 29-year-old woman, developed bilateral optic neuritis combined with numbness of the lower extremities as well as bowel and bladder dysfunction after a 22-month use of recombinant interferon alpha-2b for chronic myelogenous leukemia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-7e95a4cc88354d13a5670119f18d0793",
            "input": "Soon after introduction of insulin therapy, she developed severe anasarca, including marked peripheral oedema, ascites and pleural effusion.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f127764ff74346ec830340d4b20991f9",
            "input": "We present a pediatric patient with leukemia and a severe, L-asparaginase-induced necrotizing pancreatitis, treated successfully with percutaneous drainage used to flush the infected necrotic parts.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d4acae0cad174d168ef25c779918c306",
            "input": "Recently, some studies have also reported association between patients with juvenile rheumatoid arthritis (JRA) treated with Methotrexate (MTX) and malignant lymphoma developing.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c76346df0539401fbe10d1f82b728d96",
            "input": "Gabapentin-induced mood changes with hypomanic features in adults.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-8e4854d6ce5843d1a9a6503df28197c2",
            "input": "The pulmonary toxicity is probably induced by piritrexim.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9a04e0d03c064a92ac8dbcf7709dddbd",
            "input": "Antacid and sucralfate-induced hypophosphatemic osteomalacia: a case report and review of the literature.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3b93fdfbc95b4b14aed736b9287ece81",
            "input": "RESULTS: Evidence of neurological improvement and rehabilitation potential after severe myelopathy due to intrathecal injection of doxorubicin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b8bb982d86274eec95cf5bce81ae44cf",
            "input": "CONCLUSIONS: Cicatrization in the substantia propria of the conjunctiva by excessive lymphocytic infiltration after topically administered antiglaucoma drugs including dipivefrin is a possible mechanism of action for entropion.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9b9bd6c06603482ea7678cef5e0635f0",
            "input": "Severe adenovirus pneumonia (AVP) following infliximab infusion for the treatment of Crohn's disease.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6e54dd6c92a541d589f17c9cbf3ff188",
            "input": "We report the syndrome of inappropriate antidiuresis as a much earlier side-effect of carbamazepine administration in a 29-year Nigerian female patient with generalized tonic-elonic seizures.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e6648a17ebbf4d3399e5c36e6171e836",
            "input": "We report a cae of paranoid psychosis following use of a decongestant containing PPA and summarize the case report literature of psychiatric adverse effects to PPA in which doses were known and stated to be within recommended guidelines.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1cd2336ff1b5462b9709c9c4f2b5083d",
            "input": "Dapsone-induced erythroderma with Beau's lines.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-91ca83f0cba44c42ada454a3410a8cf2",
            "input": "A 72-year-old woman with a history of thyrotoxicosis presented with sore throat and fever two weeks after starting carbimazole.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4cf47b9645aa4f3bba70fdbb1ecc4d24",
            "input": "Nail-changes induced by penicillamine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9e2e11787aab425fbb0a5ba929583d95",
            "input": "Verapamil is widely used for the termination of paroxysmal supraventricular tachycardia (PSVT) with little proarrhythmic effect.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-8c5e6beb57aa48bb92d620ba4fa449d1",
            "input": "The reported cases of in utero exposure to cyclosposphamide shared the following manifestations with our patient: growth deficiency, developmental delay, craniosynostosis, blepharophimosis, flat nasal bridge, abnormal ears, and distal limb defects including hypoplastic thumbs and oligodactyly.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-df4f5da0e9084dcb81201b478a14bf09",
            "input": "CONCLUSION: A 37-year-old African- American man with G6PD deficiency developed hemolytic anemia, hepatitis, orthostatic hypotension, and aseptic meningitis simultaneously after using trimethoprim-sulfamethoxazole.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-7672577175744317aa599bcc596d3bee",
            "input": "Findings on discontinuation and rechallenge supported the assumption that the hair loss was a side effect of the paroxetine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-44db843e1581416ba8c8c5a946ff5144",
            "input": "Since the thrombocyte count started to increase immediately after initiation and dropped immediately after discontinuation of ciprofloxacin and tazobactam/piperacillin and all other drugs were discontinued already before or were started after the nadir of the thrombocyte count, these two antibiotics were regarded causative.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f27c6cc0b7324ef99997e9f1e2f33062",
            "input": "The nephrotic syndrome developed in a patient receiving therapy with gold for rheumatoid arthritis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-176240a6520b47c1b16f13fe98e57866",
            "input": "Four cases of adverse experiences with clonidine are described.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1b4be5953a334fb3b88ae55072083a75",
            "input": "CONCLUSION: The new quinolone derivatives (levofloxacin, sparfloxacin, grepafloxacin, trovafloxacin, gatifloxacin and moxifloxacin), also called gyrase inhibitors, are known for their potential to cause central nervous system-related adverse effects, including headache, dizziness and insomnia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-725ed0ab54bb4be3a033aaee2f8f7c23",
            "input": "Nail staining from hydroquinone cream.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9a15f706eb184a388af5af958424e11f",
            "input": "5-fluorouracil (5-FU)-associated peripheral neuropathy is an uncommon event.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b48fcc5328ae4538a92c4110bc1630ae",
            "input": "Two cases of sirolimus-associated pneumonitis have been reported after cardiac transplantation.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-165180437ca6423b917517376eadb2dd",
            "input": "The patient experienced muscle twitches, tremulousness, and anxiety on day 17 of foscarnet therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-641849d6c5ee409ab6c0e94d48f40b5a",
            "input": "The oligohidrosis caused by zonisamide was reversible in that the patient regained the ability to sweat within 2 weeks of the cessation of drug administration.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a275ddc9eafb4502a3ccbdb26d3f94eb",
            "input": "Concomitant administration of lithium with olanzapine may place patients at risk for NMS.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2093d0a39f914d909a2e252afc786f36",
            "input": "Gold nephropathy due to auranofin obscured by tolmetin pseudoproteinuria.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c15d17e02b0f4e44ac6ff307db938897",
            "input": "A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-795539b4d67d4b8588ddde54e90f478c",
            "input": "Flucytosine-associated diarrhea has been previously described in 6%-10% of patients receiving the drug.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-18e2a810cc714e3cbafbcf352e719bb0",
            "input": "The increasing prevalence of methamphetamine abuse and the severity of the associated ulcers should alert ophthalmologists to the problem of methamphetamine-related keratitis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a37a92e6070941a287faabe99adbf7c2",
            "input": "We evaluated a patient who developed a psychotic disorder after 4 months of isoniazid prophylaxis for a positive tuberculosis tine test.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9b2d2cc642194a63b5f06b2ceec3a4ce",
            "input": "We describe a detailed case of fulminant hepatitis induced by nevirapine (Viramune) and treated by liver transplantation.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2444f7a9b1374645b81fc8d6f6b0abbe",
            "input": "The authors postulate that two types of combined lithium-neuroleptic toxicity occur: a neuroleptic malignant extrapyramidal syndrome and a lithium toxicity that occurs in combination with phenothiazines, primarily thioridazine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-65b001147b474df99a65c9ce11987e6f",
            "input": "The events of non-convulsive status epilepticus subsided following reduction in tiagabine dosages.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-dff494fcfce84fa2a62c1796601d7318",
            "input": "RESULTS: After 4- to 14-month period of therapy with the combination of indapamide (2.5 mg/day) and fosinopril (10 mg/day) in three patients and 6-month period of monotherapy with indapamide (2.5 mg/day) in one patient, glucose levels of all patients increased and achieve criteria of diabetes diagnoses.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c70f4cb91b954f7c826a12f92b35f156",
            "input": "Anastrozole-associated sclerosing glomerulonephritis in a patient with breast cancer.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-bde74512c0c54431accf4152ba4cf999",
            "input": "We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b64d2eb4626b49839760ad77c186ed10",
            "input": "A reversible toxic liver damage was observed in a non-alcoholic woman treated with disulfiram.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-7413f6d684ac4dd0be2c67ce57cf3bf4",
            "input": "The administration of \"sweet spirits of nitre\" (4% ethyl nitrite CH3CH2ONO in 70% ethyl alcohol) was followed by acute methemoglobinemia and severe anoxic metabolic acidosis in infant twins, Methylene blue administration reversed methemoglobinemia in both, but one twin died from the consequences of hypoxemia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5da2f67f035848bf863cec750f073ac1",
            "input": "Delusional parasitosis associated with phenelzine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b1b3ba698bb84166be3091603633ceec",
            "input": "The reported case represents an unusual association between medication with the proton pump inhibitor lansoprazole and the development of collagenous colitis suggesting the importance of evaluation of drug use in patients with microscopic colitis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-94847948bcc043acb1bc05e4909477cc",
            "input": "CASE SUMMARY: A 45-year-old HIV-positive man (CD4+ count 450 cells/mm(3) and history of AIDS-defining illness) presented with JHR after an initial intravenous dose of penicillin G for presumed neurosyphilis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2ba01221d1c94bdf837be7212b3a9a04",
            "input": "A fatal massive pulmonary embolus developed in a patient treated with streptokinase for acute deep vein thrombosis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-078f3d91d106423395de91394a327489",
            "input": "Tamoxifen is suggested to be carcinogenic both through direct genotoxic and epigenetic mechanisms.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-7053efe178e14587b780f107d373ffe4",
            "input": "Bull's-eye maculopathy associated with quinacrine therapy for malaria.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-bc67b8b585f4494c826399b59cab2144",
            "input": "PURPOSE: We studied a case of vortex keratopathy that was associated with the use of atovaquone.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-88e5b9aa2b1c438bb276c0965c565170",
            "input": "This report describes a probable case of infliximab-induced membranous nephropathy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-96cb269571ee4ba5b64b185db230048b",
            "input": "Massive prolapse of the urethral mucosa following periurethral injection of calcium hydroxylapatite for stress urinary incontinence.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-51b1bd85bc1140b089c3b771a7017e35",
            "input": "Paradoxical precipitation of tonic seizures by lorazepam in a child with atypical absence seizures.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-98090726ade44c8dbfae2eebc8891053",
            "input": "Interference with the cortisol axis by the microtubule antagonist, CPH82.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5e95b9f30e214d88a125f5e680180f6d",
            "input": "Carbamazepine hypersensitivity syndrome is a rare, life-threatening condition.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5a43e910a9104f29b4ed6667298a6f95",
            "input": "We report a case of an 11-year-old boy who experienced an anaphylactic reaction after administration of bacitracin ointment.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-06f50ebc67014b0abdb82279ee4fc5a4",
            "input": "Multicentric hepatocellular carcinoma following phosphate diethylstilbestrol therapy for prostatic cancer.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-593f3a96fbde49f0931cf58913653d13",
            "input": "In one case, disulfiram was the only potential teratogen exposed to the fetus.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-da37a0b6e516435e9380cc4b4777f4b2",
            "input": "We have recently encountered a patient with acquired haemophilia who developed a thrombotic left middle cerebral artery distribution stroke while being treated with pFVIII.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-70ecd4c73f214789889578754ee424b5",
            "input": "We describe 2 patients with cutaneous lupus erythematosus who developed severe dapsone reaction after low dose therapy, with a fatal outcome in one.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-46544d38ad4e4d9d95a3a73b5db0ae39",
            "input": "Amphotericin B overdose in pediatric patients with associated cardiac arrest.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ed1a3417be524a6eb91789bbabf1fbbd",
            "input": "Two patients with osteomyelitis who developed reversible cholestatic jaundice during treatment with oxacillin derivatives are described.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0c56007866cf49edb078d2085123fb64",
            "input": "Here, we describe a case of Vogt-Koyanagi-Harada disease occurring 4 months after the start of interferon alpha treatment, probably induced by the immunomodulatory effects of interferon.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-22564b7f182d41d9afdf2f5871479d37",
            "input": "Isoniazid inhibits the conversion of tryptophan to niacin and may induce pellagra, particularly in poorly nourished patients.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-007629d59c354dd3b140e0a8264dceb5",
            "input": "Moreover, treatment with immunosuppressive drugs such as cyclosporine, cisplatin, tacrolimus, and interferon-alpha can induce a condition resembling RPLS.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c31651213e8548239cb66830f79730b7",
            "input": "CASE: We report a case of a woman with severe human insulin-induced lipoatrophy who has been treated exclusively with recombinant DNA human insulin since the onset of IDDM.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a6e7b9e036c247fb94c98fd76dca45e1",
            "input": "We report a case admitted with a first-detected, symptomatic paroxysmal atrial fibrillation in a healthy patient after self-medication with vardenafil.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-93bef3cc272e4423acd2ed8e0ccb7d1b",
            "input": "By means of the in vitro heparin-induced platelet activation (HIPA) assay it was shown that standard heparin and the LMW heparins Fragmin and Fraxiparin (Sanofi Labaz, Munich, FRG), as well as the enoxaparine Clexane (Nattermann, Cologne, FRG), all induced platelet activation with the patient's serum.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-fec56aa9cab848539e543ce1cca0184e",
            "input": "CASE REPORT: A six-year-old boy with transfusion-dependent beta-thalassaemia developed a unilateral hearing loss shortly after commencing desferrioxamine therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-36b1106ccb464f1a9ff26fe31438f563",
            "input": "Physicians should be aware of the potential for developing a gemcitabine-induced radiation recall reaction resulting in hemodynamically significant pericardial effusion.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-061d189d80e545108661c1d0694fe02d",
            "input": "An apparent link is described between the use of MMF with prednisone to treat pemphigus vulgaris and the development of red blood cell anemia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c36fffe687754f0dbb2aa6d8f9f014e7",
            "input": "IFNalpha-induced recurrence of Graves' disease ten years after thyroidectomy in chronic viral hepatitis C.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-06728f8dd51b4e03b36ed88210251c06",
            "input": "BACKGROUND: Aphthous stomatitis, a common mucocutaneous disorder, is a well accepted complication of sirolimus therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-df6424917c66441e97e7ef7081f44a88",
            "input": "CONCLUSION: Healthcare professionals should be aware of the possible development of serotonin syndrome as a complication of initiation of fentanyl and other phenylpiperidine opioids in patients treated with SSRIs.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c56f862317ae4fbb84daf8c6fbaf9b00",
            "input": "Symptoms and signs of augmentation were related to low plasma levodopa levels, abating 75 minutes after oral levodopa administration and reappearing after 3 hours, closely mirroring the rapid rise and fall of plasma levodopa concentration.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-13fcb94255c2464a996deacd3768f7ac",
            "input": "Amiodarone-induced dysthyroidism.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b3f1c3fd97ff4f1ca7194ed48825eb19",
            "input": "This case had radiation fibrosis, so we suggest that radiation fibrosis may be another contributor of the occurrence of ILD in patients taking erlotinib.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-7cffd34ff8864a9392a3263754259897",
            "input": "Symptomatic hypocalcaemia and renal impairment associated with bisphosphonate treatment in patients with multiple myeloma.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-77020d73da24429ba849e4f2d7951cba",
            "input": "A 22-year-old black man developed fever, chills, fatigue, night sweats, tender lymphadenopathy, and a generalized, pruritic, macular eruption 3 weeks after starting minocycline therapy for acne.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-90a866818fcc40d48514cf1ab7722f73",
            "input": "Abdominal wall ulceration and mucinosis secondary to recombinant human interferon-beta-1b.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-fdce552856cd48bb9d536f41fb9f4407",
            "input": "We describe a case of poisoning with 3,4-methylenedioxymet-amphetamine Ecstasy that presented with all the features suggestive of a fatal outcome, including a creatinine phosphokinase level markedly higher than any previously reported.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4c3d635032ce45f4bd56bcc52766eda3",
            "input": "We describe a case of an NHL patient who received rituximab and developed symptomatic, biopsy-proven multinodular bronchiolitis obliterans with organizing pneumonia (BOOP).",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-811d4363ceef420cbb430718cb71b8b5",
            "input": "A patient with an allergy to a macrolide antibiotic was given tacrolimus and developed a sudden cutaneous reaction.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e2c7bfd2cd0e4491a49eb9601fc64e1c",
            "input": "Gemcitabine-related radiation recall in a patient with pancreatic cancer.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f62b542d079f445a824f37cd88886b13",
            "input": "This eruption emerged after 1 month of therapy with salsalate, persisted for as long as salsalate was administered, and cleared within 3 weeks of discontinuing the medication.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e4143952ce414147ad7c1bcc72091946",
            "input": "Amikacin-induced type 5 Bartter-like syndrome with severe hypocalcemia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-de99a84c61454e1aa1341462a91a39ed",
            "input": "A new type of minocycline-induced cutaneous hyperpigmentation.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ebc79d6633fe4e5ebd71b780237f01f3",
            "input": "We report a case of acute generalized exanthematous pustulosis (AGEP) induced by salazosulfapyridine in a patient with ulcerative colitis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a659990450714bc88b0db5d8ba8c0458",
            "input": "Six patients with no previous signs or symptoms suggestive of coronary artery disease developed acute coronary ischemia/infarction shortly after cis-diamine-dichloroplatinum II (cisplatin) -based chemotherapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c2155bcf93ca488a88a1e2bebfe308c1",
            "input": "We describe 3 AS patients treated with etanercept for active AS who developed new onset of CD while AS related symptoms responded well to etanercept.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9d2fe08fd0b84173ad394c6de78422bc",
            "input": "To our knowledge, this is the first case of spontaneous remission of MTX-associated gastric LPD after discontinuation of MTX therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f8959376ed59421888e4990598fa2dce",
            "input": "Zidovudine use in pregnancy: a report on 104 cases and the occurrence of birth defects.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3ea68be583e64cf7995c2ec763e392db",
            "input": "The patient was diagnosed with carbamazepine toxicity related to the introduction of ritonavir.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-fdca12df7120462f8752e41ee0fb7f0f",
            "input": "Although fluoxetine-induced headache occurred in one patient, the other five reported no side effects at the doses used.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e62ec65b0d8f402cb03036e27886b186",
            "input": "Pulmonary hypertension during lithium therapy: clinical case study.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-570a7dc647d94c1a9553312e7a6265e8",
            "input": "In this report, we describe a patient receiving lenalidomide in whom dyspnea, fever, hypoxia, and diffuse pulmonary infiltrates developed.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3d5c768c903741a6a777fc5b8c5eff78",
            "input": "Inappropriate antidiuretic hormone following adenine arabinoside administration.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9880009875134b74bf211b86583a9241",
            "input": "Lithium therapy was discontinued because of poor compliance to the medication and intolerable polyuria.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-57262d214dc246f2b4d2262435c779e3",
            "input": "We describe the exceptional development of AML and lung cancer in a patient with previously diagnosed CLL in minimal residual disease status after fludarabine treatment followed by autologous peripheral blood stem-cell transplantation.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6c4e4b7ae2a64f07a0c50c2487533164",
            "input": "Interstitial fibrosis of the lung is a potential complication of methotrexate therapy for psoriasis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-89f5dc97b98d4fa5a79c7e77b53cec92",
            "input": "Secondary hyperparathyroidism in certain patients with lithium nephrotoxicity is also possible.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-41c17659ca964170894d1ed237a3ce77",
            "input": "The authors presented a case of pulmonary hypertension during lithium therapy, while she has been on lithium for 6 years.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f885e309d009469aa854f3240c59ff09",
            "input": "Development of Crohn's disease in a patient with multiple sclerosis treated with copaxone.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5d21c06168464a1ba1a8530f5cc0d9f2",
            "input": "Methamphetamine's extensive physiologic effects, inconsistent street purity, and multiple routes of administration offer many possibilities for injury to the cornea.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f86729e2254a4a65bef3bc2f162ae731",
            "input": "Neuroleptic malignant syndrome in an adolescent receiving olanzapine-lithium combination therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b8f4348c76144ef59547350bed7ddb1e",
            "input": "A case of acute cardiomyopathy and pericarditis associated with methylphenidate.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5dfd74767324431691e8729991e334aa",
            "input": "Autopsy findings were consistent with bleomycin and oxygen-induced pulmonary damage.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-34b42936253c4a1f84dec8f491b219cc",
            "input": "PURPOSE: Symptomatic visual field constriction thought to be associated with vigabatrin has been reported.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-09f55b5fe33a436c974257a80bd81d4e",
            "input": "Carbamazepine-induced systemic lupus erythematosus-like disease.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1850ea93e3e9434ab099b82b95c78625",
            "input": "We report a case of biopsy-proven acute tubulointerstitial nephritis associated with a second course of flurbiprofen, a nonsteroidal anti-inflammatory drug of the propionic acid class.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-fb418246990c4842968a427d4aca4d56",
            "input": "BACKGROUND: Headaches have been reported as a potential side effect of capecitabine therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a3e5702cf1b14fceab73e4ae2bb63693",
            "input": "Pseudomembranous colitis readily occurs in at least certain population groups receiving trimethoprim-sulfamethoxazole.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a60a3ac911374d4484d12b59e876197d",
            "input": "Pravastatin is associated with myotonia in animals.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-82acdc10ec844bc0b624ee4edbf3e940",
            "input": "Infliximab and its serious adverse effects are discussed, and other cases of osteomyelitis with infliximab use are also reviewed.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-cd49ec33c6e54b89939d8cae1fff35c8",
            "input": "The incidence of angioedema secondary to losartan, an angiotensin II receptor antagonist, is unknown.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1ee05b14ab2b402781c2e2f6c953e904",
            "input": "Dipyrone-induced granulocytopenia: a case for awareness.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c864c04fea6f469b9c8355c560cd3c7a",
            "input": "Pneumocystis pneumonia should be considered in asthmatic patients taking methotrexate who present with fever, pulmonary infiltrates, and hypoxia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-373223f6bda941bdba02aa54d836a67b",
            "input": "Despite these antithrombotic effects, the patient developed repeated venous thromboembolism during treatment with low-molecular-weight heparin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-597febda59b74723abac4d270eb9dd90",
            "input": "The elicitation of a movement disorder by trazodone: case report.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3067f4a530ec4bfcb8f4f41c6141b267",
            "input": "We report the case of a 20-year-old woman originally from Cameroon who was infected by the L. loa parasite and developed severe hepatitis, identified 1 month after a single dose of ivermectin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-bd4601f259f9488987ee3f8ba1c27f8b",
            "input": "However, we have recently had four cases of clofibrate-induced myopathy in patients with diabetes insipidus due to hypothalamic lesions.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-fded4787f99448d796b75aa5303f0a0b",
            "input": "Toxic hepatitis due to combination therapy with methotrexate and etretinate in psoriasis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0274507a5b434db9a700351d99997505",
            "input": "We describe a case of interstitial hypoxaemiant pneumonitis probably related to flecainide in a patient with the LEOPARD syndrome, a rare congenital disorder.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-24ac0158ae624c0f8de9940093e26d4f",
            "input": "The patient's other comorbidities and medications have not been suggested as possible interactions with sertraline that can cause rhabdomyolysis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-8514cadb93264b4d8cfd398e017e68e5",
            "input": "However, several case reports have suggested that clozapine could also cause TD.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2678bb7345024bc79d72c927d0c1e25d",
            "input": "Therefore, although garenoxacin reportedly causes fewer adverse reactions for cardiac rhythms than third-generation quinolone antibiotics, one must be cautious of the interference of other drugs during hypokalemia in order to prevent TdP.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-20252be88e9d4f6c9caa0bfb687f8f00",
            "input": "Severe dapsone hypersensitivity syndrome.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-20dd6685620045999f5bb3332ac04395",
            "input": "Sorafenib induced tumor lysis syndrome in an advanced hepatocellular carcinoma patient.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f4a177b8444141d29814ed45e6415336",
            "input": "The authors suggest that in the absence of any proven benefit of itraconazole prophylaxis, and given the interaction of this drug with vincristine leading to severe and even potentially fatal toxicities, the combination use of these drugs should be avoided.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-06a2970c5ba34d34baabc9b75c45f93c",
            "input": "We report four patients, three of whom first developed psoriasis and one who had an aggravation of the condition during treatment with interferon-alpha.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-25b76e1e2c134c879b39d116c37526cc",
            "input": "Escape atrial complexes, which occurred following junctional premature complexes, failed to initiate tachycardia in the control state but tachycardia was always reinitiated by an identical escape sequence after procainamide.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9eb2f0ab6c7844db8fdb6a258f0548c1",
            "input": "Prominent eye movements during NREM sleep and REM sleep behavior disorder associated with fluoxetine treatment of depression and obsessive-compulsive disorder.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9fae2eaeb49a41b8accd7bf887bd13ce",
            "input": "We describe 2 male patients, a 49-year-old with psoriatic arthritis and impaired renal function and a 43-year-old renal transplant recipient, who both sustained a marked decline in glomerular filtration rate in conjunction with a selective inhibitor of cyclooxygenase-2 (COX-2), rofecoxib.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a07e33310e034c559199fa68b5e0f645",
            "input": "Paralytic ileus in patients undergoing bortezomib treatment has been reported, although a definite attribution to bortezomib administration has not been established.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4643dbcc6c214dfba77dad27a5a37bc4",
            "input": "A 52-year-old Black woman on phenytoin therapy for post-traumatic epilepsy developed transient hemiparesis contralateral to the injury.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-8bf51389d75243c1bc01223e1170d1ac",
            "input": "A 45-year-old woman with steroid-dependent Crohn's colitis, successfully managed with maintenance infliximab infusions and methotrexate, developed a lupus-like syndrome eight months after her initial infusion.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4bee8b45b0f24356b585628390a9bc29",
            "input": "Metronidazole neuropathy.",
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                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d6597ca4a6bb41eeac8e8f4f1fc34b3e",
            "input": "Case 3: A 29-year-old female alcoholic complained of general fatigue and a slight fever after 1.5 years of abstinence with cyanamide treatment.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-925b214fdb364c209950b5737a57cad3",
            "input": "A woman developed delusional parasitosis when taking phenelzine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e51e781e499648f696a3c9d38a1e689f",
            "input": "Tacrolimus (FK506), an immunosuppressant, has been associated with mutism in adults after liver transplant.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4940ee2b12254f209d4d3fc07715790b",
            "input": "This is the first reported case of suspected DIAN due to cefuroxime.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-52009e42af1940ccba3bc867b9e5ea36",
            "input": "Pellagra encephalopathy among tuberculous patients: its relation to isoniazid therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d100d1306e4f48d39046cfa3bd536c78",
            "input": "The association of central diabetes insipidus (CDI) with lithium use is rare.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6f0987ed5c694d6ab4ac82505d6a64e0",
            "input": "Intravenous sodium bicarbonate appears to be indicated prophylactically in combating the associated metabolic acidosis due to absorbed formic acid.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-12d1d1185a174cdc9dfdbd73eb7d79ce",
            "input": "This case and a review of the literature show the severe and unpredictable nature of ethambutol toxicity and its potential for irreversible vision loss despite careful ophthalmologic monitoring.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-bf1424765222440c8be5bb44b031310d",
            "input": "In all three cases, autopsy revealed gross and microscopic features indistinguishable from those seen in the Hamman-Rich syndrome, and methotrexate hepatotoxicity was present in one.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-59f911de9a394dbcbba418b58fba5165",
            "input": "Massive CBZ OD may produce a reversible encephalopathy that includes cortical hyperexcitability, a profound burst-suppression EEG pattern, and cranial nerve areflexia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-90fbcd5b1ad84d5e9e5f173858e44dbe",
            "input": "Two patients are described who developed sensory neuropathy after the ingestion of 30.6 and 114 g metronidazole respectively.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4b9c584e3c604164900b3d8be0a3464d",
            "input": "We report a case of fulminant neuroleptic malignant syndrome in a man aged 70 developing within 12 hours of starting six-hourly intravenous metoclopramide.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-dd91b9660cc04286a58d3ad3af10fef2",
            "input": "Surprisingly, we found that three patients appeared to develop tardive OGC while taking clozapine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-01c77af44a2a4074a75fd783b2717031",
            "input": "We report a case of Zidovudine induced anaemia and bone marrow aplasia in a patient infected with HIV.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-880144778c65425ab8b1c6c097b6749e",
            "input": "Valproic acid induced coma is presented in an adult patient without a history of metabolic disease.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2c47bae36c6d4ec9904d2ad987a31dd7",
            "input": "Prick tests and intradermal tests with a series of dilutions of carboplatin and cisplatin were performed on three patients who had exhibited medium and severe hypersensitivity reactions to carboplatin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9f42b8a7f3844a8ea0c5eb16606065f7",
            "input": "This is a report of a renal transplant patient with Pneumocystis pneumonia who developed chemical cellulitis and ulceration following the extravasation of intravenous pentamidine into the soft tissues of the left hand and forearm.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-86257a882ed041d49137fbf68dc478c2",
            "input": "Mycophenolate mofetil-induced neutropenia in liver transplantation.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6639c6b5a02648de82969c36fcda267d",
            "input": "Acute hyperphosphatemia caused by sodium phosphate enema in a patient with liver dysfunction and chronic renal failure.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b3b8507292fc47229c1f9f8646fd9ab0",
            "input": "Central nervous system manifestations of an ibuprofen overdose reversed by naloxone.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e25751581801435e9e3dd57131cafc34",
            "input": "A 22-year-old drug-abuser injected flunitrazepam tablets dissolved in tap water into her left femoral artery and presented with clinical signs of acute ischaemia of the left leg.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-345684fb54374cdfb03811ed9288fc4c",
            "input": "Ulcer became worse after tobramycin and gentamycin treatment for 2 days.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3198917f5f654e89a1cb8a59c402e0ec",
            "input": "Linear IgA bullous dermatosis occurring after carbamazepine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b6bb5d22bd634a048c9b5bbe98f048e0",
            "input": "This is an image and brief case report of a 13-year-old boy who presented with severe rash and systemic symptoms after starting oxcarbazepine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ad2f8331241c469aa937e2773e88a9e4",
            "input": "Type II heparin-induced thrombocytopenia (HIT) is an immunological disorder characterized by antibodies to heparin-platelet factor 4 complexes and a high risk of thrombotic complications.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a11e0de500494a19988106b27ee24e35",
            "input": "We present a case of HUS in an advanced ovarian cancer patient treated with carboplatin and gemcitabine, and described its favorable outcome after chemotherapy interruption and supportive care with a 1 year follow-up.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b62cf9f4431f46b2b97c1e6da6f16242",
            "input": "Triazolam-induced nocturnal bingeing with amnesia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6d68cb67c6e84e6d8ec8652d88a8c362",
            "input": "The international literature regarding opportunistic infections after immunosuppressive therapy with alemtuzumab with particular attention on fungal infections has also been reviewed.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e4aa555cfd704a73bf7f33b3f2b219b6",
            "input": "CONCLUSIONS: Amphotericin B overdose can be fatal in children and infants.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6a0e62df5be1444bb46ae10adb368c25",
            "input": "CONCLUSIONS: Amphotericin B seems to be the probable cause of the seizures.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0a3e4e4225a04413a27a46c116af54a1",
            "input": "Propylthiouracil-induced sensorineural hearing loss associated with antineutrophil cytoplasmic antibodies.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4303593577954bbdafcc00d650cc34a4",
            "input": "We report a case of Thrombotic Thrombocytopenic Purpura occurring as an allergic response to trimethoprim-sulfamethoxazole therapy (Bactrim, Septra) in a Jehovah's Witness patient.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d8b806e80c294145a3359bf96b52fbe1",
            "input": "Vanishing bile duct and Stevens-Johnson syndrome associated with ciprofloxacin treated with tacrolimus.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d3cabe25c2bb433f8e2b9826d628d232",
            "input": "Amphotericin B nephrotoxicity in humans decreased by salt repletion.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0aa2f5d2982446118107884a6993b37f",
            "input": "Cephalexin rash in infectious mononucleosis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a88af67f506b48d1a3ebae9ba01e019c",
            "input": "This is a rare case of ARDS associated with lithium intoxication.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-bf4263b381b94e729b707a3c5624acf1",
            "input": "A 77-year-old man developed ankle, hand, and facial swelling 2 weeks after starting rosiglitazone.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a043bcc6cb4b4169867117f6fac8819e",
            "input": "We postulate that gastritis caused by dexamethasone, mucositis caused by doxorubicin, and the unique anatomic nature of a Meckel diverticulum may have contributed to this extremely unlikely and previously unreported event.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d07d48a058404f7da81b46babda95218",
            "input": "Muscle biopsy revealed variation in muscle fiber size and few vacuolated fibers which were features of colchicine-induced myopathy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ea01f2cccdc14116a10c556b66b3e622",
            "input": "We report a case of generalized cutaneous sclerosis associated with muscle and oesophageal involvement in a patient exposed to herbicides containing bromocil, diuron and aminotriazole.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b60f9b9f0c2e4e088549b7b53cbc7ce5",
            "input": "Acute interstitial nephritis due to pantoprazole.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-167ee6f121054762a702fe35e4afb874",
            "input": "We report the case of a female acromegalic patient in whom multiple hepatic adenomas appeared soon after danazol treatment for uterine fibromatosis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c76a8e115d07450f8cc69fc040b657d9",
            "input": "We describe a 5-year-old girl showed recovery of vincristine induced cranial polyneuropathy with pyridoxine and pyridostigmine treatment.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c599b8d07d244ba6ad1a1f43c183365b",
            "input": "We report on a patient with renal artery stenosis who had only 1 kidney and in whom acute renal impairment developed with transient anuria after the administration of captopril.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-844069c5d2f04ccb9962d92af8ab42b6",
            "input": "We present a 46-year-old African-American man with AIDS who was admitted on two different occasions within three weeks for signs and symptoms of meningitis after using trimethoprim/sulfamethoxazole (TMP/SMX).",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c76f22cd34fc4318bbdb6174ff05df6d",
            "input": "Increased libido in a woman treated with fluvoxamine: a case report.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-299e90197f544527b9f170eae7bb5def",
            "input": "Physicians using this \"new\" drug must be aware of the potential danger of sulfonamide-induced injury to the urinary tract.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-490fa4566cbb4e2d9741da04b586f479",
            "input": "Cefoxitin therapy for Mycobacterium fortuitum bacteremia with associated granulomatous hepatitis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-06caa4113be2450a90146ec1935a4eb5",
            "input": "Zolpidem tissue concentrations in a multiple drug related death involving Ambien.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-18cc92cb4a5c4bb2bd4c363445cd9e04",
            "input": "Osteomyelitis occurring during infliximab treatment of severe psoriasis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c1c002ba6cd243688324d185990d566a",
            "input": "Sulfadiazine crystalluria revisited.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a3ad6074bfec4bef9d99e1a57646b206",
            "input": "Amiodarone is well recognized as an anti-arrhythmic drug containing a high dose of iodine with considerable potential to cause thyroid dysfunction.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a00ba477990147e0936a41e2b7e20775",
            "input": "BACKGROUND: Reproductive endocrine disorders characterized by menstrual disorders, polycystic ovaries, and hyperandrogenism seem to be common among women treated with sodium valproate for epilepsy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d7d7ddca6da645dcbe7c902940fc2a6e",
            "input": "Hepatotoxicity associated with 6-thioguanine therapy for Crohn's disease.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c9281e65ec674546a7d1dbc02e595500",
            "input": "Anaphylactoid reaction to methylprednisolone pulsed therapy for multiple sclerosis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6c0ec369446147c5bbcd88ab6f3ecb35",
            "input": "Scrotal ulceration induced by all-trans retinoic acid in a patient with acute promyelocytic leukemia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-17f2bd917ed9488aad1365d09adeb7f2",
            "input": "Possible interaction between lopinavir/ritonavir and valproic Acid exacerbates bipolar disorder.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4f62faf7a6ac44ed85b823bd1a97efb6",
            "input": "It is very likely that the dexamethasone used in the antiemetic drug regimen contributed to the development of osteonecrosis in these patients.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-123a635fcacb4114ba262ad9765db077",
            "input": "Dilated cardiomyopathy associated with chronic overuse of an adrenaline inhaler.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2b30998abd1547329420a745f65accf3",
            "input": "Response of a promethazine-induced coma to flumazenil.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-599a54e8a0e549af8520c7e9ee749f13",
            "input": "Prolonged responses were achieved with low doses of HU (3-10 mg/kg/day) and higher doses were associated with mild reversible hematologic or hepatic toxicity and no further increases in Hb.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-7b94a998d3f940baaba5caafac78e85f",
            "input": "Thalidomide neuropathy in childhood.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f8dc1c7ece04437a8e1e8460f2932f75",
            "input": "We report 4 patients, 2 on methylphenidate and 2 on dextroamphetamine who presented with acral cyanosis, livedo reticularis, or Raynaud phenomenon.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-77f4973a9cb9416bb32a35225dcdf1d2",
            "input": "Capecitabine was discontinued and the allergic reactions resolved after the woman took diphenhydramine for 1 week.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-08579f8f58f043e48fe4f76a967564fa",
            "input": "We report a case of fatal pulmonary toxicity in a patient with advanced non-small cell lung cancer who received erlotinib.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-7934a0e5c61a40af8438bc8b291a56e2",
            "input": "Heparin-associated thrombocytopenia: successful therapy with the heparinoid Org 10172 in a patient showing cross-reaction to LMW heparins.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f6c5d1a9485f4dbdb6734679622e0c88",
            "input": "Though physicians treating large populations of patients with HIV are well aware of this complication, only one other report of nevirapine-associated SJS has been documented in the dermatology literature.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3c825f49850544908467d98eb96249a2",
            "input": "Three patients receiving gold salt treatment for rheumatoid arthritis developed severe aplastic anemia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-78b1d4d2217e4ad3a47ec714f96d079b",
            "input": "We believe that this is the first description of acute hepatitis caused by an idiosyncratic adverse reaction to gliclazide or to one of its metabolites.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-af6da57fced5454ea3ba0eb3f09904ad",
            "input": "Transient leucopenia and thrombocytopenia associated with sodium nitroprusside infusion.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2e9716c4c336496f92046f8d15cbee20",
            "input": "Our patient developed both nephrogenic diabetes insipidus and renal tubular acidosis with a temporal pattern that demonstrated a link between foscarnet therapy and these abnormalities.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b0b11afc8da74185b570db08fa81dec8",
            "input": "A case of tuberculosis in a patient on Efalizumab and Etanercept for treatment of refractory palmopustular psoriasis and psoriatic arthritis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6d7d320894b24e589a8be08590f36e26",
            "input": "Penicillin-induced Jarisch-Herxheimer reaction.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-dbfef1174f1b4ddea31065eec0e251af",
            "input": "Under the suspicion of amiodarone-induced acute pancreatitis, amiodarone was substituted by propafenone.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-80d2de00b9e14463b2e3187c607e7495",
            "input": "Although vasculitis has been reported in the course of hairy cell leukaemia, it has only rarely been reported as the consequence of cladribine treatment.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2e00a80902f349c8aa254ba532c2e8ee",
            "input": "Imidazoline intoxication in children.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5c727fdc39a14d5e8733ef51c071ac4d",
            "input": "Reversible heart failure in a patient receiving etanercept for ankylosing spondylitis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-43dbda6bb5d44144ae0d8dfa31fb47f3",
            "input": "METHODS: A retrospective report of the first case of gemcitabine-related HUS, in a patient with metastatic pancreatic adenocarcinoma, treated with a variety of standard therapies in addition to rituximab is presented.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ca01f765b1e14b8ba06366549e6b16e1",
            "input": "Severe acute encephalopathy following inadvertent intrathecal doxorubicin administration.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4acfc2f4099a48fcb14ed528916030fa",
            "input": "There is no consensus on the treatment of ticlopidine-induced marrow aplasia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-472bf2d517a14e3bac18b54a70235e7b",
            "input": "We have successfully overcome severe neutropenia in an RA patient treated with gold salts, using granulocyte colony-stimulating factor (G-CSF), reducing the duration of neutropenia and risk of infection.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-fda8fb3e4d6149dfbf079aa2c7ed96d0",
            "input": "Dexamethasone treatment of amiodarone-induced thyrotoxicosis (AIT) with or without persistent administration of the drug.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-65aafa42e0df48de88ff067749472240",
            "input": "Acute acoustic nerve palsy associated with vincristine therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e19900772140457095a0d4848895633d",
            "input": "In this case report, we have described a patient with Crohn's disease who developed subfulminant hepatitis B after the fourth infusion of infliximab due to an unrecognized HBs-antigen carrier state.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a688a97527864327942b953b496c7ab7",
            "input": "The concomitant use, however, of colchicine and statin has been associated with the rapid onset of muscle weakness.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-46c3fe07d4454db2bade3dd098678686",
            "input": "Quetiapine-induced leucopenia and thrombocytopenia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-bba1d501feea4364a8c7b193f987d0b6",
            "input": "When the trazodone was reduced, the involuntary movements promptly ceased.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f9ef7a0b5d0049659a9c4a5f63bdce43",
            "input": "The potential for progressive brain injury and subsequent disability related to intraventricular IL-2 therapy is discussed.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-823bd657624c4f1a90b314c60d499d26",
            "input": "Nifedipine may induce, or aggravate, pre-existing, gastro-oesophageal reflux.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-dfc54eeac3e34161a7373c622affe25f",
            "input": "After extensive neurological 'work up', we realized that the anisocoria was related to the transdermal scopolamine patch that we had prescribed for weaning off the opioid.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1d6b7c97980642c584beba0d3518283b",
            "input": "Conversely, diffuse interstitial pulmonary fibrosis should be considered in the differential diagnosis of patients receiving methotrexate who develop bilateral pulmonary infiltrates seen on chest roentgenograms.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-7f2ae19807e446cc8847b260a45edee2",
            "input": "We report a case of successful surgical management of arterial thrombosis after percutaneous thrombin injection of a femoral artery pseudoaneurysm in a 69-year-old woman.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9b6fa755f7a1464d9f667240eaa1880c",
            "input": "As these cases revealed, close monitoring of blood chemistry is mandatory after starting spironolactone, and patients should be advised to stop spironolactone immediately if diarrhoea develops.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3824ca04486746ae9a9a0a91134e9d94",
            "input": "However, a large case-control study included three cases of either Stevens-Johnson syndrome or toxic epidermal necrolysis associated with ofloxacin use, but no details of the cases were given.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ce103bd3d6844b41a305c8ee46daadbf",
            "input": "However, follow-up revealed that gestational diabetes when associated with norethisterone had a lesser risk of emerging diabetes mellitus and impaired glucose tolerance.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-398e680f878d4820864265fcb864b741",
            "input": "Nine delirious patients suffering from lithium intoxication were examined with the Mini-Mental State Exam (MMS) to describe the clinical course of the disorder.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0617598d0e084aa18e73b6d55ebdbe0d",
            "input": "After abstinence from oolong tea his delirium resolved.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4dd375d6caad4cda8d602b86ceb063d3",
            "input": "The development of systemic lupus erythematosus (SLE) after 38 months of therapy with recombinant human interferon gamma (rIFN-gamma) was observed in a patient with rheumatoid arthritis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f86652fa922b40eebed7c403451960ba",
            "input": "Diclofenac-associated hepatitis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-db1e4aae4ca04bf0b0d14699e2fe1f66",
            "input": "The use of rituximab has been uncommonly associated with delayed pulmonary toxicity.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2eb774ba26054e35891a3b975b94061a",
            "input": "Although the t-AML developed following oral etoposide therapy, the child had previously received high-dose, multiagent chemotherapy, and rearrangement of the MLL gene was not demonstrated.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-eba53ce7eabb4a2f90580ab3d05ee669",
            "input": "We report a case of exfoliative dermatitis clearly linked to intravenous and intraperitoneal administration of tobramycin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5c6c6a8375f74e94836fe1d1bf651310",
            "input": "No cases of renal acidosis, and only one case of nephrogenic diabetes insipidus, has been previously reported as a complication of foscarnet treatment.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-4038cb0034484cc8b8eb73e93b5be7ee",
            "input": "Successful treatment with carbimazole of a hyperthyroid pregnancy with hepatic impairment after propylthiouracil administration: a case report.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a1764d33da08439e941cb0aa7a33476a",
            "input": "After five and six weeks of continuous oral administration of methylprednisolone, the boys developed steroid diabetes.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e8807b5f49124e7ba98e9d27a070ed8e",
            "input": "We describe a 15-year-old female patient diagnosed with acute lymphoblastic leukemia presenting with status epilepticus after receiving intrathecal methotrexate.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-776b121b13c94a3b993ced1ded4fe319",
            "input": "We report an additional case of isotretinoin teratogenicity in which the patient had agenesis of the cerebellar vermis, multiple leptomeningeal neuroglial heterotopias, hydrocephalus, and abnormalities of the corticospinal tracts.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-889ab8d7e47e4f2285320edf2f01fac0",
            "input": "Clonidine-induced bradycardia in patients with spinal cord injury.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d1fb2893d9b1486190f783aca8b4694e",
            "input": "Spontaneous nasal septal perforation with antiangiogenic bevacizumab therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-8f138794bd4c4b91b6236545b8531405",
            "input": "A 25-year-old man with a history of mid-borderline (BB) Hansen's disease developing a reversal reaction after starting dapsone and rifampin therapy is presented.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-82ee5b6c528b40269758474f8f88f92b",
            "input": "Withdrawal of Depakote resulted in resolution of the effusion.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9405b248bba94357a4374c48574d9f9e",
            "input": "A 54-year-old man, treated with amiodarone, developed thyrotoxicosis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a899eb80fe234e67af3d39decd2aa6d0",
            "input": "Delayed neurotoxicity of intraventricular interleukin-2: a case report.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5789895f99424d35bdc0d02c3b77048a",
            "input": "Extensive forearm deep venous thrombosis following a severe infliximab infusion reaction.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-8eee73870eed419aa00c3d2732916dd7",
            "input": "CASE SUMMARY: A 57-year-old female with cardiomyopathy and \"sulfa\" (trimethoprim/sulfamethoxazole) allergy documented as pancreatitis presented with symptoms consistent with pancreatitis after use of furosemide.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9f93d33400d54585817b3cf18f7b017c",
            "input": "Increased awareness is needed on the possible occurrence of LPD resembling gastric cancer in rheumatoid arthritis patients treated with MTX.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1fc8f27e469f47b3813d239b06391c57",
            "input": "Severe hyperkalemia occurred in a patient with radiation pneumonitis and glaucoma shortly after beginning prednisone therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3e70668063074830ae79019ebc15d93a",
            "input": "Choroidal hemorrhage associated with systemic tissue plasminogen activator.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-21f631690db04dc7bf31d59a758b6d84",
            "input": "Gold nephropathy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ad0eb733a8eb4ab296f3b714810e389c",
            "input": "Statin-associated myasthenia gravis: report of 4 cases and review of the literature.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e5f94164a974422b9c4c9e73f8d120b4",
            "input": "Propranolol: an unrecognized cause of central nervous system dysfunction in patients undergoing cardiopulmonary bypass.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-266afd0ee1e042aeb4e3aeb04036c970",
            "input": "This case extends the spectrum of fludarabine pulmonary toxicity to include pulmonary nodules.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-cf18a0c4e9c94c13963a2ff2f7e310f6",
            "input": "DISCUSSION: Patients with 5-FU-induced ectropion experience tender, red, scaled lids, making contact lens wear difficult.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-12514448c163405ebbc09d4134810155",
            "input": "We describe a case of fibrosing alveolitis, diagnosed by lung biopsy, in a patient receiving amiodarone which responded to corticosteroid therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-89edca2cd00a43b5a278536e72ed2cb6",
            "input": "OBJECTIVE: To describe a case of severe skin necrosis resulting from peripheral intravenous administration of low-dose vasopressin in a patient with catecholamine-resistant septic shock.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-78358011936f4a859ee147e148b542b0",
            "input": "With the negative viral serologies, the clinical picture was most consistent with an infectious mononucleosis-like syndrome produced by the minocycline ingestion.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-26a6d241a3954af4baf2a742acabe9b4",
            "input": "Hepatotoxicity induced by cyproterone acetate: a report of three cases.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9f4066b20b1143a688238141691543be",
            "input": "This unusual pattern of low-grade endometrial carcinoma adds to the spectrum of uterine neoplasia associated with tamoxifen therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d8b94ecddac9426aa8218fd58c5b76be",
            "input": "Extrapyramidal symptoms are well-documented complications of therapy with haloperidol, even when small doses are used.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5e759181e0cc4b39a77d7fc82875757a",
            "input": "Cholelithiasis and thrombosis of the central retinal vein in a renal transplant recipient treated with cyclosporin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-934aee459ace488f9235656350b45826",
            "input": "Bortezomib-induced paralytic ileus is a potential gastrointestinal side effect of this first-in-class anticancer proteasome inhibitor.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-62d9031246ea4896922557892c0168e9",
            "input": "Twenty-four hours after the administration of gemcitabine, a symmetric, bullous, herpetiform eruption appeared on his trunk and upper limbs.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1c64391c1abe4cdbae3b3a60c5367134",
            "input": "Nitrofurantoin-induced acute liver damage in pregnancy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-11d4a24fe92b41ea992a13fa3611342c",
            "input": "Two infants developed hyperkalemia shortly after cessation of prolonged ACTH therapy for infantile spasms.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-25023b79b4734e8085ac1a0734dc45fd",
            "input": "In both patients the rippling phenomena worsened with pyridostigmine treatment but markedly improved after immunosuppression with azathioprine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-aab36b482f2b48d3ae645eae2ad9d93f",
            "input": "Successful desensitization to high-dose methotrexate after systemic anaphylaxis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e5aa069d721a4c61802f40658a0db679",
            "input": "We conclude that neurosurgeons and neurologists should be aware of calcium antagonist--related ileus in patients treated with nimodipine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-7ad052f5d96c498c9edbfd91c583ea9c",
            "input": "Significant clinical improvement of the porphyria followed withdrawal of the diphenylhydantoin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-131e71503b8e4770aaeaca11187df167",
            "input": "We believe that mucositis was a contributing factor to this case of fatal hyperkalemia after administration of succinylcholine, with a mechanism similar to that reported with thermal injury.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-e41d0816b3454a6a852c29cdcdbfee87",
            "input": "It was highly suspected that finasteride was associated with the anterior subcapsular opacity on the lens, and the patient therefore discontinued use of finasteride.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-beae2b8ccada4c4882d8883f278bcd01",
            "input": "Improved awareness of and further investigation into the neurotoxic effects of ofloxacin may enhance its safe use.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-284aeb0b11474ca0b7dcab5f8aad6d27",
            "input": "It was restarted 6 weeks later, and 10 weeks after that, the patient presented with fulminant hepatic failure, which resolved rapidly after cessation of nicotinic acid therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c6a49eb8c55446e3a98c3e373b7dc849",
            "input": "She developed neurotoxicity with an adjustment dosage of valacyclovir for a cutaneous zoster infection.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1babc1dafb1e4be093c49293c22808fd",
            "input": "DLST is a good diagnostic tool for AZA allergy, especially for severe drug allergy cases.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ebf9eb0f67fc43bd96b89fe928d8989e",
            "input": "A case of a 21-year-old woman who had developed mild hepatotoxicity while receiving choline magnesium trisalicylate therapy is described.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ae3febb01afb447684bfdc9a61c2b482",
            "input": "No explanation for this delay was found, other than the possibility that magnesium sulfate treatment impeded lactogenesis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-124ceec68c254a84ae4c5726351f56a7",
            "input": "Idiosyncratic factors involving vasopressin receptor affinity and distribution, vasopressin-associated vasodilation in some vascular beds, and the effect of vasopressin on the renin-angiotensin system may further contribute to impaired tissue perfusion.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-58caabf2294a4266918b001dd14be36f",
            "input": "OBJECTIVE: To report a case of marked elevation of serum creatine kinase (CK) associated with olanzapine therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-961b01d22e39487bac2a33499a4138c5",
            "input": "We describe the development of cutaneous scleroderma in 3 patients coincident with the use of bleomycin in low cumulative doses of less than 100 U.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5a2784f7b7ec47baaca369f412723aa4",
            "input": "A 40-year-old man with relapsing-remitting multiple sclerosis (MS) developed primary central nervous system lymphoma (PCNSL) after having received 21 doses of natalizumab monotherapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-89e5ec4bbe2547f1990dcc7fae4c106e",
            "input": "While the mechanism of dextran-associated renal failure remains unsolved, plasma exchange seems to be effective therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-92e366ac54b746f2b708d8ad3ccdfbfb",
            "input": "This paper reports an autopsy case of a 78-year-old male with multiple nodules in the liver developed after long-termed administration of phosphate diethylstilbestrol (PDES) for prostatic cancer.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-21a866bfc1464f7abdfaa1cc0f638be9",
            "input": "We cared for a patient with progressive renal impairment who presented with blurred vision, QRS broadening and cardiac failure due to chronic cibenzoline intoxication.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-992dfb9ced444e06899f05a20e210658",
            "input": "Piloerection induced by replacing fluvoxamine with milnacipran.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-14605d94efb74b0db2689ad1dfe93f58",
            "input": "Psychotic disorder associated with isoniazid.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-637e3cdfe92b46b0ab4d89523cf4e0fc",
            "input": "Seizures associated with ofloxacin therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-965bf092301b42a29f227296ba17e637",
            "input": "We report a child with yolk sac tumor who developed localized pigmentation after the first course of chemotherapy regimen that included cisplatin, etoposide and bleomycin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d2f38c76bd3d48658d573f90bd40af29",
            "input": "Gemcitabine-induced pericardial effusion and tamponade after unblocked cardiac irradiation.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f6fe8a048f254ae2a182c9d9421715f1",
            "input": "Preliminary results suggest that the higher concentrations of dextrose induce increased histamine release from blood cells, and that this phenomenon is more marked in diabetic, and particularly diabetic-allergic, individuals.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3e8cb360634d4dd3be1d1aa87061d142",
            "input": "Acute sensorineural hearing loss following intravenous ketoralac administration.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-50cc608a83d54b1591f7d76ed824fafe",
            "input": "Lithium-induced Creutzfeldt-Jakob syndrome.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-79d7c14dda3b4828ab757b3b9c3f84e2",
            "input": "To our knowledge, drug-induced fever has not been reported with the use of diltiazem hydrochloride, a commonly prescribed calcium channel blocker.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-8db6fdf8f43b42578f0805d98eb53c20",
            "input": "Tacrolimus-induced HUS: an unusual cause of acute renal failure in nephrotic syndrome.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-49c5cad5821b431b888367c44ac6da0a",
            "input": "A case report of a patient with probable cisplatin and bleomycin-induced TMA is presented.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0ea6da8515cc4fc0889218a2a3f1f548",
            "input": "The autopsy findings and a detailed medical history supported the conclusion that clozapine-induced hypersensitivity myocarditis was the most likely cause of death.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0399d9c28f82425fa00e8cfd1955c89e",
            "input": "Recent studies have shown that under experimental conditions ferrous sulfate may reduce the gastrointestinal absorption of orally administered levothyroxine sodium in patients with primary hypothyroidism.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-c5f8c4ba135643e98dbbbc9cf93459c5",
            "input": "Our patient had headache, mild fever, nausea, vomiting, rash, and eosinophilia after 3 weeks of disulfiram therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1d02c9f703274e60898953fc1390f26e",
            "input": "We present a case of a sustained monomorphic ventricular tachycardia following adenosine infusion.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-55b1f7e654094935be4e50b911c8764e",
            "input": "Sotalol-induced bradycardia reversed by glucagon.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-861a3da312fa405baf8934a5564c50fd",
            "input": "Mesalamine-induced hypersensitivity pneumonitis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d6db82d0769a47feb7a51df06b938da7",
            "input": "Destructive thyrotoxicosis appeared 4-6 months after starting IFN-alpha, followed by Graves' hyperthyroidism within 8 to 11 months.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-651e4116d2d5434483dab1f3b995a6a8",
            "input": "Trichiasis associated with prostaglandin analog use.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6c21d23e6b2a42fd89421e01e2549bfc",
            "input": "OBJECTIVES: A delayed stroke-like leukoencephalopathy has been observed in patients receiving methotrexate (MTX) for childhood leukemia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-53266354bf674883a04d676317ad3cc1",
            "input": "CONCLUSION: This case illustrates a potential link between dermatologic and ocular 5-FU toxicities.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-bc11cf3e51284cb6a0ce45a82adb8c9a",
            "input": "Methotrexate-induced pneumonitis in patients with rheumatoid arthritis and psoriatic arthritis: report of five cases and review of the literature.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-64469ab7ddac4559abf0bb0129b29171",
            "input": "RESULTS: A 34-year-old man acquired visual field defects and severe vision loss in both eyes after intravitreal injection of triamcinolone for diabetic macular edema.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-02895324e45c4414b4811d9c0d18c268",
            "input": "METHOD: We describe two patients who presented with diabetic ketoacidosis after treatment with quetiapine and risperidone, respectively.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9b2ffabf4a8c4f00834d4a395cccab6b",
            "input": "This case showed sequential manifestation from transient thyrotoxicosis to the appearance of TSH-receptor autoantibodies, and then the occurrence of Graves' hyperthyroidism during IFN therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d624f0ddcfb64bedaf66635c00b47f1e",
            "input": "Because the cerebellar toxicity may be worsened by continuation of therapy after initial onset of symptoms, prompt termination of HDARAC is recommended.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3c36b07e6f5b4fa680648b69e08f8da7",
            "input": "Painful erosion of psoriatic plaques is a less common sign of methotrexate toxicity that may precede evidence of bone marrow suppression.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3243aefefd64482fb82291c53849a0c8",
            "input": "These nail changes gradually disappeared when the dose of clofazimine was reduced.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b4f768f9ab01459daab096ab595652e9",
            "input": "Atypical neuroleptic malignant syndrome associated with olanzapine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d28b55501db84311a5f60209833be257",
            "input": "Myoglobinuria and acute renal failure associated with intravenous vasopressin infusion.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1a6a1af252264876a941f46cee64ce62",
            "input": "A patient is described who developed a poorly differentiated sarcoma after cyclophosphamide was used to treat his rheumatoid arthritis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-29b4718f7c27471e97dde51ca6f7cefa",
            "input": "Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-468e5ebc866e4c5dbb2709ac2ffa3262",
            "input": "To our knowledge this is the first report of pancytopenia due to MMI, where the usual hypoplasia found is replaced by massive plasmocytosis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-763dbeddb08c40679b0c70647c56a393",
            "input": "Hyperkalaemia with renal tubular dysfunction by oral therapy of sulfamethoxazole-trimethoprim (co-trimoxazole) is described in 2 elderly Japanese patients with lymphoid malignancy, who developed Pneumocystis carinii pneumonia and improved.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f9258db832e048dc84c1d3a2f8d9b6c7",
            "input": "Upon discontinuation of MTX, her ascites resolved, and her arthritis became more active.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-23d83008f58747fc98471a45e26662b0",
            "input": "The authors think that although lamivudine is widely used and well tolerated, it can cause ADRs, which are reversible after drug withdrawal.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0346949b9aca47099e94a4a298c988eb",
            "input": "Severe hemolytic uremic syndrome in an advanced ovarian cancer patient treated with carboplatin and gemcitabine.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9b12f80468754f5dae81a4bfe69f391c",
            "input": "Disseminated salmonellosis in a patient treated with temozolomide.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ca9a60f46b7b4475be8282620bde9bb0",
            "input": "After taking cholestyramine II sachets twice daily for two months she presented with lethargy, confusion and drowsiness.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d9fdc03376734ab3a461c158c619e98e",
            "input": "A retrospective epidemiological study of deaths from hepatic angiosarcoma (HAS) in the U.S. showed that during 1964--74 there were 168 such cases, of which 37 (22%) were associated with previously known causes (vinyl chloride, 'Thorotrast', and inorganic arsenic) and 4 (3.1%) of the remaining 131 cases with the use of androgenic-anabolic steroids.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-f67f7a8017374b2482e201fc276da034",
            "input": "CONCLUSION: In some abstainers who take cyanamide for several years, thin septum-like liver fibrosis progresses along with the emergence of ground-glass hepatocytes.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1d71a3ed50db4e1db5c37b0867cba74f",
            "input": "A possible case of carbamazepine induced pancreatitis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-a8f8006923ea4423b6231ae6a04531c7",
            "input": "We report 5 cases of acute reversible renal failure coinciding with the onset of treatment with captopril in patients with severe drug-resistant hypertension.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-8147f1b2a40642ce8016dc3487d9ade0",
            "input": "Development of an extensive skin rash following a single dose of MTX may be an early warning sign for life-threatening bone marrow aplasia.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-8bc74a674d04426e8585107034a16261",
            "input": "Progressive hypoxemia mandated endotracheal intubation 1 week after rituximab administration and led to death 4 weeks after admission.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-3ed3ba21010f40449fabb3252d22643b",
            "input": "Since 1979, over 30 published case reports have documented the relationship between phenylpropanolamine and stroke.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ec56f8b15d6244479ef1d747385c3042",
            "input": "Our series of 3 patients supports a causal connection between bleomycin and scleroderma.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-6ebbfa8236694bde8113ffbbac73a13d",
            "input": "Pure red cell aplasia associated with fenoprofen.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-61ce437a4ff140b886393ae49fc3db8e",
            "input": "There is a putative role of liothyronine administration in precipitating or activating hyperthyroidism.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-5185e6b8eb15472288fdd13258dead90",
            "input": "An 83-year-old man receiving glipizide 10 mg bid developed symptomatic hypoglycemia within three days of adding trimethoprim/sulfamethoxazole (TMP/SMX) to his regimen.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d46dba89091c4b01a3206b9285262bab",
            "input": "CONCLUSIONS: Clarithromycin may be a cause of fulminant liver failure either alone or by inhibiting the metabolism of other drugs.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-1bb77b95d4c04604bc04a88a74df68af",
            "input": "Ciprofloxacin is among the standard treatments for infected ischemic ulcers; in the rare case of ciprofloxacin-induced hemorrhagic vasculitis, it might be interpreted as progression of infection, instead of a complication of the treatment, thus leading to faulty diagnosis and treatment.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-b52323f1f5fc4428aa764cbaafd1b892",
            "input": "Although the data indicate an immune-complex cause for gold-salt nephropathy, the incident antigen (or antigens) and mechanism of action remain unidentified.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-66f15e6170db405fa07c32d464f90549",
            "input": "Proton MRS examination demonstrated a persistent lactate elevation during metronidazole treatment.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-fb3c26cfae4a4c37923df7636286b979",
            "input": "Trimethoprim-sulfamethoxazole-induced aseptic meningitis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-accbc5458f7e4dbe993d1b619342149a",
            "input": "It is concluded that simultaneous administration of ciprofloxacin and tazobactam/piperacillin may cause marked thrombocytosis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-2321f7f2df24457782be1e08aa2523a8",
            "input": "We describe a case of life-threatening hyponatremia associated with sibutramine use in an obese woman.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-ac83ab303ac449a491a3de07d1d41a4a",
            "input": "Erythema multiforme bullosum due to rifampicin.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-0da07d919ebb444287e0ba9e7583a01d",
            "input": "However, other factors or drugs (e.g. cresol) are thought to induce MH.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-fbcb20a5bdb3412d8bcfedfc6df279ee",
            "input": "Catatonia associated with disulfiram therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-d8ac3b90b0c44ac998c3f8df1701dc23",
            "input": "Acute aluminum toxicity after continuous intravesical alum irrigation for hemorrhagic cystitis.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-9a65e3c226c342fb890ac10a9bd65098",
            "input": "Psoriasis-like skin reaction in a patient with rheumatoid arthritis after sulphasalazine therapy.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-af81009cdd88419b9e1b0ee8821f07f1",
            "input": "Quinine and its isomer quinidine are well-known causes of iatrogenic hypoglycaemia, due to excessive insulin secretion.",
            "output": [
                "adverse drug event"
            ]
        },
        {
            "id": "task1495-286bcaf01a7e402ba1d33e238992f2da",
            "input": "Although hypophosphatemia induced by aluminum-containing antacids is rare, treatment of peptic ulcer disease with a combination of two aluminum-containing agents may increase the risk of clinically significant hypophosphatemia.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ddfe75ab2943475094b4fb44791364c0",
            "input": "The criterion for severe infection was inpatient hospitalization.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-391036355e4240dda45667031a182f74",
            "input": "The patient began her prescribed radiation therapy and 5-fluorouracil radio-sensitizing chemotherapy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-676f43f8f6f44cbbaffe4c084ec6c99f",
            "input": "Genitourinary malacoplakia in renal transplant recipients: pathogenic, prognostic and therapeutic considerations.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-7e1bd421a8c04fc496b7e42fcb1ceb7f",
            "input": "Laboratory tests revealed cyclosporine nephrotoxicity, cytomegalovirus infection, and prediabetes.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d2dd90f353314479b4d8ec03718cbf3f",
            "input": "The patient is currently under treatment with prednisone 20 mg/day for systemic lupus erythematosus and with oral mesalazine 2.4 mg/day for Crohn's disease.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c1cccc140c0c4467839664f1b27e2088",
            "input": "Scans were performed without opioid drugs and 30 minutes after intramuscularly administered meperidine, morphine, hydroxyzine, hydroxyzine plus meperidine, butorphanol, and nalbuphine.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d00a90387dcc4b2f90147f92c61309de",
            "input": "Tricyclic antidepressant (TCA) morbitity is primarily due to cardiac arrhythmias and hypotension, which become more refractory to treatment as acidosis progresses (Ann Emerg Med. 1985;14:1-9; Clin Toxicol. 2007;45:203-233; Flomenbaum N, Goldfrank L, Hoffman R, et al. Goldfrank's toxicologic emergencies. 8th ed. McGraw-Hill Companies, Inc, 2006).",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c80ffc582ad24dcc90295a0b92fa5799",
            "input": "Signs of severe liver disease included elevated aminotransferases, conjugated hyperbilirubinemia, significant coagulopathy, hepatosplenomegaly and ascites.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-12166817f3b54e0f9276e7281ad317c1",
            "input": "We report a case of pelvic actinomycosis presenting as cutaneous fistula.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-0b85e8771df14608ac27e102c0c18a00",
            "input": "The clinical features included fever, severe myalgia, documented fungemia with F. solani, an ecthyma gangrenosum-like lesion next to a peripheral venous catheter, and disseminated pustules.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-4b46dd791d2d45e0b4e169d88fd8b085",
            "input": "CONCLUSIONS: Herpes zoster reactivation may occur following LASIK.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-51ac21b66bf94e0196d4924720036404",
            "input": "CLINICAL FEATURES: A 74-yr-old, 51-kg woman with a history of hypertension controlled with 5 mg.day-1 enalapril and 50 mg.day-1 atenolol was admitted for evaluation of low back pain, loss of appetite, and weight loss.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-083ee805d85244a490e18c1965b2cf8c",
            "input": "Subsequent investigation revealed that the factory produces phenylpropanolamine and that both patients, shortly before becoming ill, were inadvertently exposed to methyl nitrite, a critical reagent in this production.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-55d553a3f2714708a10650c4816c3cc8",
            "input": "'Spontaneous' hypertensive episodes with monoamine oxidase inhibitors.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-cd4fc9c94daa4656bffd6eec9aa323fa",
            "input": "CASE REPORT: A 64-year-old female patient with metastasized esophageal carcinoma received simultaneous chemoradiotherapy of the upper mediastinum with 50.4 Gy and cisplatin/5-fluorouracil.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-822cf10af2eb4994a09a214dc230d9fb",
            "input": "Interventional pain management is an evolving field, with a primary focus on the safety of the patient.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c63f7ac3150c490ea4f82cbec1277ac1",
            "input": "Further studies are needed to determine the optimal dose and schedule of DMSO application and to assess its efficacy in extravasation injuries from other vesicants.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-4042f1b7107c43a9b8d3128604dd3f85",
            "input": "OBJECTIVES: The objectives of this medicolegal case report were the following: 1) present details of a chronic pain patient (CPP) on chronic opioid analgesic therapy (COAT), who diverted her opioids and was terminated from treatment, and subsequently committed suicide; 2) present both the plaintiff's and defendant's (the COAT prescriber) expert witnesses' opinions as to the allegation of medical abandonment of this patient and other allegations; and 3) based on these opinions, to develop some recommendations as to how pain physicians can minimize their medicolegal risk when termination of the physician-patient relationship is warranted.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-aaa363da4019450ba5f06dc24ee23870",
            "input": "The role of IFN-beta in inflammatory musculoskeletal disease is unclear.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-4afbe0a0a4cb4f67b807033319980ccb",
            "input": "We demonstrate linezolid's high CSF penetration and its CSF bacteriostatic activity against E. faecalis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-2850a3fc14a84a88b2e47e0fce5af48a",
            "input": "Changes in the parameters of oxygen metabolism in a clinical course recovering from potassium cyanide.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-73e3d7658e144c189ecb5ebc8e6bcb8b",
            "input": "Severe chronic active Epstein-Barr virus infection mimicking steroid-dependent inflammatory bowel disease.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-44ee639f811e4e0f913c9568373aad18",
            "input": "These findings, together with increased urinary copper excretion and the absence of clinical improvement, are compatible with a generalized defect in copper metabolism, transport or storage.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-bc395c80f572494ba534b652d58a1cd1",
            "input": "The outcome of 19 other children with severe aplastic anemia who received ATG was also summarized.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-25a20a91f27a4703a2148c0c52028115",
            "input": "PURPOSE: To report our experience with late vitritis associated with keratoprosthesis (KPro).",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-25493c0f3030403d8d77f1bd1b17618f",
            "input": "We conclude that, though rare, E. avium can be pathogenic in humans and that E. avium bacteremia is associated with gastrointestinal abnormalities.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-40d92d89c54c415cbc9241107d57694b",
            "input": "Clinical examination revealed no evidence of vasculitis nor coagulopathy and initial neuroimaging (i.e., computed tomography, angiography, magnetic resonance imaging) demonstrated no features consistent with aneurysm, arteriovenous malformation (AVM), cavernoma, nor cerebral metastases.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-92be5a25dd054ab1984bdf820e0b449a",
            "input": "Inhibition of cytochrome P450 seems to be an important mechanism.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-85e5c9b2129944c4b0c443958f0eb723",
            "input": "His fetishistic behavior was treated successfully using mirtazapine 15 mg/day.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d00d14f886c644f584abb322efa69ffe",
            "input": "As the number of cases of refractive surgery in Australia increases, optometrists will encounter this condition more frequently.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8ddd9921e9ba4cbe9ec60dd4dd6b7c7a",
            "input": "RESULTS: Seven patients showed marked visual field constriction with some sparing of the temporal visual field.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-276ef8d044c349b793af891f509c689f",
            "input": "One patient with ineffective erythropoiesis did not have significantly increased hepatic iron stores but responded to the administration of desferrioxamine.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e59631885bcd489ab26c19c2e0410f79",
            "input": "RESULTS: Five of the six patients experienced intolerable exacerbation of parkinsonism.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-22ff8e5beae94d77b209bf8994731789",
            "input": "Spinal myoclonus resembling belly dance.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-33bc84d3919f4ba788c1c74217cceabe",
            "input": "Accidental overdose of multiple chemotherapeutic agents.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e2b69bd98ce047a1a02a0d675c403918",
            "input": "It has activity against both the positive and negative symptoms of schizophrenia, which has made it an alternative to traditional antipsychotic medications such as haloperidol.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3fe936b7140246ca99eaade4a73070a4",
            "input": "When the patient was subsequently treated by parenteral administration of Org 10172 as anticoagulant over a period of several weeks the number of platelets rapidly increased and the patient almost completely recovered.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-70c735c6265240f6886af5f0af3519a1",
            "input": "His diarrhea, consisting of 10 to 12 loose stools a day, had continued for approximately two weeks and was accompanied with abdominal cramping, fever, anorexia, and weight loss.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-f48b9a5351734d3495ff81794dab5896",
            "input": "The clinical course is usually aggressive.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-22d3b5265aa84884bcd272acdb7f8040",
            "input": "He was successfully transplanted.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-596ed6e1e3b64e858c5e8d51c144c695",
            "input": "After forty-eight hours, he developed jaundice and transaminasemia, which subsided by the eighth day.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a49c6c505b5846778fc55fa79f8b7d9c",
            "input": "Marrow aplasia lasted for 4 and 10 days, peripheral neuropathy for 15 and 42 days, gastrointestinal toxicity for 3 and 5 days, and hypertension for 5 and 14 days.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-4c3c3a11145c4502bb4b83c8dd0dbff7",
            "input": "Furthermore, this analysis does not provide evidence for a heightened risk of AML/MDS in CLL patients, despite treatment with known leukemogenic agents.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a0063459fc3c4008944f87e2cd9594f2",
            "input": "After the most recent surgery, he suffered transient cauda equina symptoms.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-74da2a69014e4348967537e9b39b392c",
            "input": "Although the enuresis ceased, she developed throbbing headaches, nausea, vomiting, paresthesia, lethargy, fatigue, and altered mental status over the next 7 days.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-acfa8ab2941b4d18bb13e3b45b6051a2",
            "input": "Mitomycin C is a powerful antineoplastic agent.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ee9853f1f6c94bffbc4584c7df831f50",
            "input": "However, reticulocytes were markedly increased in number on the 13th day of hospitalization.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-08b882498d0a4b05abaa4aa39f1b3206",
            "input": "Pramipexole is a Food and Drug Administration-approved antiparkinsonian agent, which, when used to augment antidepressants, would be considered an off-label use and should be discussed with the patient.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-4e1a6516f8424e26acffc72ee2218adf",
            "input": "Theoretically, insulin-sensitizing thiazolidinediones (TZDs) should be beneficial in this patient population.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d939bb1851864f269dd935a6f1acb853",
            "input": "Each case (stage IB and IA) occurred after initiation of the subcutaneous anti-tumor necrosis factor medications etanercept and adalimumab, respectively.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-9745d177efa84f9e93b6d77da2247785",
            "input": "Quetiapine in relapse prevention in alcoholics suffering from craving and affective symptoms: a case series.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3670cbf898a54f19ab6828d5c12bb45f",
            "input": "A 15-year-old boy developed nephrotic syndrome and acute renal failure 4 years after allogenic bone marrow transplantation (BMT) for lymphoid crisis of chronic myelocytic leukemia.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3375dcf052084c979ba58510289e4764",
            "input": "Drug eruption was diagnosed in a 4-year-old German Shepherd Dog being treated with sulfonamides for vertebral osteomyelitis due to infection with Nocardia spp.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-1b36924a9ca64e2495670dc4f81847b9",
            "input": "We report on a case associated with atenolol.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-09d5e491e4164fa29f2b6abafda1968e",
            "input": "Although radiation-induced laryngeal necrosis has become a rare complication, the combination of chemotherapy and radiation therapy may increase its incidence.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-dcdcb9824f6647b29b52dc639a71a86a",
            "input": "CONCLUSIONS: VVR stimulates mucin secretion and MCTV in the LPS-inflamed ferret airway.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-36aed2aecdcd45f7ab3ea688b9f5f36a",
            "input": "Palmar-plantar erythrodysaesthesia (PPE) is an uncommon cutaneous complication of cytotoxic chemotherapy which generally presents as a painful erythema involving the palms and soles.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-761ade2dbc3f4e0694d04f615ca4b7e4",
            "input": "The spectrum of antimicrobial activity of albendazole and its efficacy in the treatment of intestinal microsporidiosis are reviewed.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-331c07dfc7364d0fa40338b53332e7a5",
            "input": "The management of non-muscle invasive bladder cancer has become more complex with regard to initial investigation, treatment and follow-up.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d012f936bfe24029bfdbe82343b04056",
            "input": "In December 1998, he applied to our clinic for a follow-up examination.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-0def0ca66ace48a0aafb3b022f174b81",
            "input": "Calciphylaxis in a patient with rheumatoid arthritis without renal failure and hyperparathyroidism: the possible role of long-term steroid use and protein S deficiency.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-714a1596085048048b50706444ec5af6",
            "input": "Both patients were successfully treated by chemotherapy including all-trans retinoic acid (ATRA), and after reaching complete remission, they have subsequently been in continuous remission.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-6495423eea0f47c2a3f45b7bc6b3615b",
            "input": "A successful vascular procedure was achieved with full heparinization without subsequent thrombocytopenia or thrombotic or hemorrhagic complications.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-0244aa77adb04afca8ffe7379f730ad5",
            "input": "Echocardiography revealed severe, global left-ventricular dysfunction.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-9d96a55ab1284eb1bcccc0b744e34fdc",
            "input": "PURPOSE: To describe retinal pigment epithelial tear following photodynamic therapy (PDT) for subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD).",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-916af61f2e22492c83c84031805e3161",
            "input": "We report a protocol in which anticonvulsant agents are discontinued before discharge from our neonatal unit.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-25a4bfb10f6945538acd868b09619d7b",
            "input": "We report on a case of localized ganglioneuroblastoma treated by carboplatin/etoposide for 2 courses and surgery, which developed a serious GHD after 56 months.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3114b127ec2944b3b24fc3c03d105ea8",
            "input": "Accidental ingestion (five episodes) and suicidal attempts (three episodes) accounted for these visits.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-853c621e9f08454984513436d2b3eb94",
            "input": "In addition to treating the otorrhea with ear drops, one physician would add oral antibiotics (Dr.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a947a61d3ae7422eb2c0b1647eb799b7",
            "input": "In four of five eyes the LASIK flap was amputated.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-9a31a34e80d0479bacedf3ef6bd522ec",
            "input": "Peak serum concentrations exceeded 4 mcg/ml.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-b34bdbf3009c4ca9998e9a6b93642d1f",
            "input": "New lesions gradually spread to the arms and trunk (Fig. 1).",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-736ef539ed11432db05c90b6be3f2ad0",
            "input": "Transthoracic or better transoesophageal echo-cardiography and Doppler are by far the most accurate diagnostic tools that can entirely replace angiographic assessment.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-9e31fde7caa44998a43ec2d863cdf7be",
            "input": "The peritonitis in these patients differed from the typical picture in which a single aerobic organism is responsible, by the presence of multiple organisms, some of which were anaerobic.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-42939d2c64e6465eb83411bbb4c8be22",
            "input": "There was no evidence of disease progression.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-786a6fa2d3a44f7ca3ae0c7c42878f4a",
            "input": "He underwent uneventful cataract extraction surgery and intraocular lens implantation of the right eye.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-90fafcacb1f14b14b35d708e114c7967",
            "input": "Methylglyoxal bis-dihydrochloride is a drug that has been available for use in cancer chemotherapy since 1955.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3f069db970c84a2789429a729cfcc69a",
            "input": "The mean duration of clozapine treatment was 12.10+/-6.26 years.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-03f3b2ec669c4955b3abce686925c518",
            "input": "Spontaneous resolution of the thrombus such as is reported in this case is exceptional.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a827c37b92a542bca0ee9be715b09398",
            "input": "6-Thioguanine is being increasingly used in the treatment of inflammatory bowel disease but has not been reported to cause liver injury in this context.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d91dd80c79d149a5937c2c4442872ea7",
            "input": "The abscess was surgically drained, the IUD removed, and a prolonged course of amoxycillin/clavulanic acid given.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-36c3d2a43faa434ca292382311dd4cbd",
            "input": "No other drugs were detected.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-1397efbb4f5541d39ee980fc5639d0dc",
            "input": "Others as well may see a similar rise based on local trends in TB infection and disease.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-044b364a84554112a3ddc732bf272d05",
            "input": "On discontinuing the medication, the areas of severely restricted diffusion had entirely resolved, with minimal residual T2 signal abnormality.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5e7c4d5896b9498d8b615bbc33810704",
            "input": "Surgical treatment included debridement (6), grafting (2), digit amputation (1), digit dermotomy (1), and fasciotomy (1).",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-21bf980d1e5a46c09bc66d1038301ae5",
            "input": "A 66 year old HIV infected male heavy smoker presented with arthralgia, myalgia, and weight loss which was originally ascribed to nucleoside induced mitochondrial toxicity.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d392850f215a4178b6e4ce18fe31df63",
            "input": "Our observation would confirm this statement.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-fb048edb1aab4b86b9891b6047cfa639",
            "input": "Clinical evaluation of SMS 201-995.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-be8a50a47db0484ea29afc9fe880d6a4",
            "input": "The patient developed cardiac arrhythmias, acute renal failure, and anemia.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3c54426931e0465ba340f9777ada63fe",
            "input": "Patients may also experience delirium as part of their underlying medical conditions.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d366c36195b54d89a75d8c6331d33c0e",
            "input": "RESULTS: The study patients were observed up to 4 years, and none of them reported any problems.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-1327f564f35a49c9bf1e6b5149690ec9",
            "input": "During her life the patient frequently presented catamenial MA attacks with an increasing frequency during pregnancy in particular in the second and third trimesters, and then during breast-feeding.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-7aba2106d97e4b50af4ac2e140185b5f",
            "input": "L. micdadei PVE successfully treated with levofloxacin/valve replacement: case report and review of the literature.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-4af683b9c13b46d0990b5f826902af56",
            "input": "She had a history of diabetes and angina pectoris.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-7357c2b1a49746828412d748c974dfda",
            "input": "In conclusion, NCPH should be included in the differential diagnosis of HIV-individuals presenting with clinical manifestations of portal hypertension and well preserved liver synthetic function.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-319fa4d5313c405c8f1ee2c071cf7a5b",
            "input": "The mean decrease in vivo following hemodialysis for ifosfamide, chloroacetaldehyde, and 4-hydroxyifosfamide were 86.9%, 77.2%, and 36.2%, respectively.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-27b87b30357143aa90e63dc7fdcafc63",
            "input": "After positioning of a 0.035 inch guidewire proximal to the biliary stricture, the preloaded catheter was advanced over the guidewire by using the monorail technique.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5db43758cac5432195bd70b6eeded9d8",
            "input": "Osteonecrosis is a feared complication of corticosteroid use.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3bcaa76674b2427792ce232f66d44eea",
            "input": "Five days after the 3rd booster dose, in November 1996, the dermatosis relapsed on the forearms, trunk, and legs.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5c5ebfb7e1e94a33affc2cd6dd088eac",
            "input": "It would therefore seem prudent to monitor red and white blood cell counts in patients taking MMF.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-f1f554b587b641c0a03ba704b94db225",
            "input": "To the best of our knowledge, this is the first report of an association between sunitinib and gynaecomastia.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-b05b695b7d604d22b8c07a6c294b4d89",
            "input": "A p value < 0.05 was considered statistically significant.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a2be9a734870491eb3e304d3daabb457",
            "input": "RESULTS: Eight out of nine patients were abstinent under quetiapine over a period of 2-7 months.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c8670bbc4af4489093d03166be084462",
            "input": "The immune tolerance in a 12-year-old haemophilia A patient was carried out at the Faculty of Medicine, Ramathibodi Hospital, Bangkok in 1998.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-35a356049bc54d5ab6591ca9c8210711",
            "input": "The benefit of apomorphine on sexual function in some patients suggests a possible role in the treatment of impotence in PD.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ae4c8944f6cb40de8b063454952b4506",
            "input": "The our case of patient with von Willebrand's disease type I indicates that this drug is very effective in bleeding after teeth extractions.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-71840c36a004493ca5779728e9d8892c",
            "input": "Regarded as the most common and best understood of the hereditary periodic fever syndromes, familial Mediterranean fever (FMF) is a recessively inherited disease of episodic fever with some combination of severe abdominal pain, pleurisy, arthritis, and a characteristic ankle rash.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-0e9f0db7f1114969aa030980e2da3a81",
            "input": "Nevertheless, symptomatic CH has been reported in association with various underlying diseases.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a5649aec5af24e0faf8f5b2ad77cab27",
            "input": "She had been treated for pulmonary tuberculosis seven years prior to admission.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-aa81bb9ce670400bb519d4c2925962fa",
            "input": "Thereafter the maintenance dose can be small and fluctuations in the illness do not seem to occur.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-533a314889fc450daec8d741b7e3b210",
            "input": "Majocchi's granuloma of the face in an immunocompetent patient.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-bf59f23cf9ea488fb672900e01a8a97e",
            "input": "Multicenter randomized study of two once daily regimens in the initial management of community-acquired respiratory tract infections in 163 children: azithromycin versus ceftibuten.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3076f1fc613f487998ead9b6d9e80080",
            "input": "Glutathione levels were low before treatment, and increased during treatment.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-845172f22bec46cda97cefa4a632b17a",
            "input": "A patient with sinuatrial disease and implanted pacemaker was treated with amiodarone (maximum dose 1000 mg, maintenance dose 800 mg daily) for 10 months, for control of supraventricular tachyarrhythmias.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-cc5257f66633483ab813a29d4a7e3bdc",
            "input": "BACKGROUND: Nocardia exalbida was first reported in 2006.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8658a4504ec84c9baa20f142d3dd6974",
            "input": "Histological improvement with lamivudine therapy for de novo hepatitis B occurring in an anti-HBs-positive child after bone marrow transplantation.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5364c1181912456ab7b69817085aa514",
            "input": "Auto-intoxication with flecainide and quinapril: ECG-changes, symptoms and treatment.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8d0d30b5da5f42e2b6300e6e62e6b91f",
            "input": "Glucose-6-phosphate dehydrogenase deficiency was present in the former case and was thought to contribute to the lung injury.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-4d20453d69994775938488b1f2a76676",
            "input": "INTRODUCTION: Chronic constipation is a common symptom in pediatrics, and physicians often use mineral oil to treat chronic constipation in children.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-79ff9df8f8ba4e719e01eab042b93e66",
            "input": "A challenge with clozapine was feasible and showed no clinical symptoms of eosinophilia.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-fc9a82182ce143d49709fec80473bfea",
            "input": "On postoperative day 17, she demonstrated hyperkalaemia and metabolic acidosis; she was diagnosed to have hyperkalaemic distal RTA with aldosterone deficiency (type IV).",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e876398e49bc45fab671008da5296430",
            "input": "This appearance should be considered as a possible false positive in patients undergoing such treatment who are being investigated with PET scans.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d174c06bee47495a9bbac1e6aa5a018a",
            "input": "No organisms could be grown by culture of corneal scrapings for bacteria and fungi, and the condition failed to respond to topical therapy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-850c73f58bcc4a43bd45e40722c692af",
            "input": "A total of 64 patients from 10 series have received the drug from one to 25 months, usually in doses of 50-150 micrograms every eight hours by subcutaneous injection.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e1240e456eec492e823756fa1cf82f34",
            "input": "Various combinations of antibiotics have been successful in achieving cure; however, at present, high-dose penicillin (greater than 25 million units/day) in combination with an aminoglycoside for a period of six weeks appears to be the optimum therapy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-762b09fa7f02443eb5e9098a8b7f1c95",
            "input": "We report here a 34-year-old woman with complicated severe opportunistic pulmonary infection, who was treated with the newly developed antibiotics quinupristin/dalfopristin (QPR/DPR) and voriconazole.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-cbf6bdbca6ac4c32ba2569159d9fbb49",
            "input": "This was complicated by a persistent cerebrospinal fluid leak that was successfully managed by purse-string sutures over the dura around the catheter, without removing the intrathecal implant.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c22c4496969c4e6498c18710edb50bb7",
            "input": "General practitioners frequently find themselves caught between the desire to treat and relieve symptoms, and not wanting to cause or exacerbate dependence.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-cc4b19e88b1d4a7a91661ce1db0f3b4f",
            "input": "This particular form of hyperthyroidism is long-lasting because of the slow elimination of amiodarone.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c6cddde8738a4222b160d4494326eaec",
            "input": "However, adrenal suppression has only rarely been documented.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-eeeb0f123b4845b6a59d8b09e54693ea",
            "input": "We therefore assume that the risk of severe neurological complications is underestimated.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-51e6328c399a418b822fba89a5f980ee",
            "input": "In a MEDLINE search (1966 to present, English language, keywords: amniocentesis, chorioamnionitis), no report of Candida chorioamnionitis after serial reduction amniocentesis exists.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-28fb461b515c45cb8326fbc83ef70b89",
            "input": "We conclude that etanercept may be a safe and effective therapy not only in severe psoriatic arthritis, but also in cases of pustular rebound after withdrawal of immunosuppressive agents.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-067bfc67e92241a9ac5805f42de90cb7",
            "input": "Adult respiratory distress syndrome as a severe immune reconstitution disease following the commencement of highly active antiretroviral therapy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-14a00d59495d423f88fe46dea4f5d0ff",
            "input": "The only adverse effect was seroconversion of anti-hepatitis C virus after receiving 108 bottles of LC for 36 weeks.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-65223124fe82400dad85b98982bbb912",
            "input": "No recurrence was seen in the 12 to 19 month follow-up.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-898ad65d610e49f58fadd6f1066bacc5",
            "input": "Its evaluation with Doppler ultrasonic velocity detector.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-47805e2e9ca244bc93c06d80d1d76a53",
            "input": "It has a considerably lower risk of cardiotoxicity than its parent compound, doxorubicin.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c78ce9f90b8d42079ec4053a8b64f406",
            "input": "Failure to thrive is also a frequent side effect of treatment.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-04a63d52c04e4fa5bcdd5aa708433105",
            "input": "Mycophenolate mofetil used previously in transplantation, has recently been shown to be useful in autoimmune blistering disorders.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-22368d9988c64c42bac0a304d355d9be",
            "input": "RESULTS: The inflammatory mass was excised successfully, and several specimens were examined for bacteriologic presence.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8c70b34baa4f4366a6a29bc895f22985",
            "input": "Patients with metastatic breast carcinoma and similar presentations should be considered for prophylactic therapy with allopurinol and hydration before chemotherapy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-1ddd4d4d40a740389f5aac7473d0a450",
            "input": "When a CPS perforates the transverse foramen, even if no apparent VA injury occurs during the operation, the surgeon must take care not to risk cerebral infarction because of an embolism.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-540c6b1863994bc89b45449c1b447d82",
            "input": "These patients had robust responses to pramipexole augmentation of their treatment regimen.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-9f0b452ffc9348339cce5a256e0b8afb",
            "input": "When the patient discontinued taking the drugs by herself because of subsiding of these symptoms, severe panic anxiety appeared.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a221a51c74404f1593dc570c3d13eca5",
            "input": "Because his supply of amphetamine-dextroamphetamine was diminishing, he took only half (30 mg every morning) of his prescribed dosage from days 4-12 of varenicline therapy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-599d84f45b7f448a89f8ebf4e60213e3",
            "input": "A week prior, the patient was started on folic acid 1 mg orally daily and given an injection of vitamin B12 1000 microg intramuscularly that was continued every 3 cycles thereafter.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e5959d1649634d988e55dcd8ca4190e7",
            "input": "BACKGROUND: Zidovudine, a Nucleoside Reverse Transcriptase Inhibitor (NRTI) is one of the earliest antiretroviral agents used as a combination in the Highly Active Antiretroviral Therapy (HAART) for the treatment of HIV infection.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-85457291c2794cb79c07976be28f228c",
            "input": "Burn of the auricle.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c21d32e680cd40b3a8cea778ecf4b607",
            "input": "Mean duration of therapy was 5.5 yrs.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a1abd481d7e54d40ad3c54fc95d4858b",
            "input": "A pattern of possible risk factors emerges from these reports.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c28505d055ab4ba584875b92d75ddec5",
            "input": "METHOD: The case histories of two geriatric patients treated with bupropion for major depression are presented.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ecd9646ed455417b809a6acdd152ca49",
            "input": "In two patients, no myocardial infarction occurred, as shown by a normal postoperative left ventricular angiogram.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-780185342b684fcbb186b9cb3ed9a80c",
            "input": "By continuous irrigation it is frequently used to treat suppurative mediastinitis after median sternotomy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-372fed2a6f1c4a698a741999cdd7f33b",
            "input": "This ubiquitous inhabitant of the sebaceous glands and hair follicles can cause acne vulgaris.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-beb72457f6d64d809cdf85f9a84bd339",
            "input": "The Keyes technique and self-inflicted injuries.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d57bb5e950454165b7dabda5f55584fa",
            "input": "This procedure appears to be a simple, safe, and effective method for closure of a small conjunctival break.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-695abe07f896489b87ee0ef654deff28",
            "input": "We hypothesize that early glutamine supplemented tube feedings in children receiving intensive chemotherapy alone or in combination with bone marrow transplantation will result in improved nutrition with fewer infections and lower cost than TPN-supplemented patients.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c8a9df622f554b74848b0067b9276d56",
            "input": "This mode of therapy was effective in treating severe gingival hyperplasia in a patient receiving systemic androgen therapy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-6ae1325042404d78a304882cf5f0f2f6",
            "input": "No severe local side effects were observed.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-7232b578d95843b088f03a400c4b9d0d",
            "input": "Ideally, the ostium is treated by positioning the stent with a slight degree of overhang in the aorta to ensure coverage of the aorto-ostial junction.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-be5e7609874e420abab9505942a4ecdd",
            "input": "Both premortem and postmortem bone marrow sampling revealed almost complete replacement of the marrow space by sheets of histiocytes demonstrating metachromatic cytoplasmic granules.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-cd0942efb77045e3a4826031384c78cc",
            "input": "In the present study, arsenic trioxide was given intravenously for 42 days to a 56-year-old female patient suffering from chemotherapy/ATRA-resistant APL, with 43% APL blasts in the bone marrow and elevated D-dimers.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-96c190009e884fc5be2f10fad922b9ca",
            "input": "At 37 weeks of gestation, she spontaneously delivered a healthy male baby.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-1cc7e021f83d4ef39f2c8509fd79cddf",
            "input": "It can progress rapidly to high fever, altered mental status, seizures, profound muscle rigidity, rhabdomyolysis, brain injury, and death.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-455b498dde244df08223aa668f1ec778",
            "input": "The child developed the nephrotic syndrome at the age of 17 months.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-66e689518edd484ea0c311b492fc0855",
            "input": "Transrectal ultrasound-guided needle biopsy of the prostate is a widely accepted technique to obtain prostatic tissue for histological examination.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-f2cf136505fd45198717f5d17e34fb5b",
            "input": "Chlorambucil (CHL) was used in combination with prednisolone in the treatment of nine children with frequently relapsing nephrotic syndrome.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8d67cda3c58341df8de52459dd1e4864",
            "input": "Thrombotic microangiopathy (TMA) is a serious toxicity associated with a small number of antineoplastic agents.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-771cdc1c961040e0b3a452ed6d2cdbd3",
            "input": "Retinopathy of prematurity (ROP) is a multifactorial disease affecting the developing retinal vasculature and remains an important cause of blindness in very preterm infants.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e6234caed60341ad8da43bcde0908315",
            "input": "She developed pruritus, edema, and urticaria over both hands.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-345137202fb24c27b2fd5e0b1a7993ec",
            "input": "His serum carbamazepine concentration was 3.9 microg/mL (reference range, 4-12 microg/mL), and his serum ammonia concentration was 127 microg/dL (reference range, 19-60 microg/dL).",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-2a3b66df9c94419ea0c7873cb2e7ad21",
            "input": "In this case, a 51-year-old woman presented with several weeks of left shoulder pain and was diagnosed with rotator cuff tendonitis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-11ce6853afd04e05b5948b7f609f3fb2",
            "input": "Aggressive suppletion with intravenous potassium and bicarbonate combined with potassium-sparing diuretics and ACE inhibitors resulted in complete restoration of the serum potassium and resolution of the neurological symptoms.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-136f6f49ced14826ac348a1d520f067c",
            "input": "Visual changes, headache, and elevated blood pressures were present on arrival to the emergency department.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-1a400acce4fe4627a27452655da31192",
            "input": "The patient died of recurrent myocardial ischemia 3 days postoperatively.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-93f283e4ee744ec6b0f5e5274a11c34b",
            "input": "We evaluated the response to gluten restriction and normal diet by following the status of the patient's jejunal biopsies and skin lesions.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c1ed385aa001473990f2431fed2a3fad",
            "input": "Despite normal coagulation parameters, the cerebral hematoma enlarged over 36 hours, as documented by sequential computed tomographic scans, to produce significant mass effect, which prompted surgical evacuation.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-0ba6248cd6d748538b71de6264ab9c4c",
            "input": "Benzoyl peroxide (BP) is commonly used for topical acne treatment and has long been known to be a weak allergen and a strong irritant.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-881ca070aaf145d583795b8a2f7814e5",
            "input": "PURPOSE: The purpose of this report is to emphasise the role of the Acute Pain Service in managing local anaesthetic epidural infusions for postoperative pain management, the importance of vigilant monitoring, and to offer some guidelines to using local anaesthetic epidural infusions.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8551e857f26f42b68b1a8374daa42829",
            "input": "Cerebrospinal fluid examination showed albuminocytologic dissociation (total protein concentration 118 mg/dl and 152 mg/dl, respectively).",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-7bce5fafdf644d9f8ea866df24d6494b",
            "input": "We present a case of interaction between ritonavir and carbamazepine.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-15d0e5c9ebf147ddaf8facb9a59d3f61",
            "input": "Asthma is one of the most common chronic medical conditions.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e2fa4a62bad9453da9fbd36b05659e1b",
            "input": "The patient had Hodgkin's disease and responded to chemotherapy and amphotericin B.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-db254b1b045d4adaa07827c31218fc8a",
            "input": "Neuroleptic malignant syndrome is easily confused with other health problems; distinctions between it and malignant hyperthermia, heatstroke, and lethal catatonia are made.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-790798c863a24078803d8760de3be067",
            "input": "In reviewing the literature, the authors discuss the currently available therapies for such infections of the spine, and highlight the growing incidence these and other formerly rare infections.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8486071da7a14a8696c81a1d4d5230cb",
            "input": "The present report describes four cases of this association in which tamoxifen had been administered to all of the patients.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-52824427a4404572934d1eaecdfb4e26",
            "input": "In addition, the mother drew large volumes of blood from the patient under the pretense of following a physician's orders.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-dd37fc6362d948c2882dad73068c418c",
            "input": "Here, we report on six cases of NE in patients with acute leukemias.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d214ba83e95d413793747b93eaffb4cb",
            "input": "Biopsy specimens of the upper tarsal conjunctiva in soft contact lens-associated giant papillary conjunctivitis were taken during (1) chronic exacerbation, (2) brief remission, and (3) intentional exacerbation.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8a434ec55b88400899a72f5e32834d01",
            "input": "This drug has not been studied prospectively in large numbers of pregnant women and lacks the Food and Drug Administration's approval for gestational use unless benefits clearly outweigh potential fetal harm.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-63aca9ab592b4c19a1ce17546289f88b",
            "input": "We concluded that flumazenil can antagonize the sedative effects of promethazine at these receptors to return the patient to a wakeful state.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8b9d1bec622c44f68b2e1912a09719c2",
            "input": "There had been one episode of chest discomfort in her past history.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-4ff21065d1e5459f86bb77127ba835de",
            "input": "Synergistic effect of carbapenem-teicoplanin combination during severe Rhodococcus equi pneumonia in a kidney transplant recipient.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a8d3b83299344dc9a84438962aa9ff2e",
            "input": "Patients in whom CSC develops while using corticosteroid inhalers or nasal sprays should be alerted to the possible relationship between CSC and these agents.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-f4ff8eb863934fc4a3b34eb1cd22368e",
            "input": "Asthma is a chronic inflammatory condition of the airway, characterised by the presence of airflow obstruction which is variable over short periods of time, or is reversible with treatment.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a9bcf34373314e99a90e52b2e97c563b",
            "input": "After adequate hydration and administration of oral colchicines, the patient's right knee pain subsided and the uric acid serum level returned to normal.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-70597e750e574e94b1b83fb2fc699500",
            "input": "He presented the following day with uncorrected visual acuity (UCVA) in the affected eye of 3/200 and organic foreign body deposits underneath the flap.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a584f5a6b0e94a7f8d163f9976c8e224",
            "input": "Analysis of the case which went to trial indicates that there is not one prescribed protocol which must be followed; the definition of standard of care is broader than that.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-fe3cd05450f641c597ee1dd800a3239d",
            "input": "Syncytial giant cell hepatitis recurred after transplantation and was efficiently treated with ribavirin.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-f722c655254d4b019d729e9fdce6ef53",
            "input": "There is potential for this side effect, and additional caution in the use of this drug should be followed.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-65fb812fd39a4f53acc29db2573faacf",
            "input": "Clozapine is the least likely anti-psychotic to induce extrapyramidal symptoms (EPS).",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5e8a40974f4c4694b0c279ad234344fd",
            "input": "Vital signs were within normal limits.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-0af846991cda49beafa9b2ab761bee23",
            "input": "The use of real-time ultrasonography enabled us to image this infant's aortoiliac thrombosis in an accurate, noninvasive manner and monitor the effectiveness of thrombolytic therapy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e5e371f535c4443986fedf786f26c561",
            "input": "Samples with concentrations exceeding the linearity were diluted.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8960d23b212d4deeb671428fdda692c5",
            "input": "The images obtained were compared with images from patients without corneal disease.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a0e68cf2e59d457794e4719a780f0b65",
            "input": "The right palm also showed similar changes.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-cf6bc3123911439eb66ab8689ed8ff03",
            "input": "Attenuation of drug-induced anxiety dreams and pavor nocturnus by benzodiazepines.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c4cfd09b961a429592c327de335c3fb6",
            "input": "Reported here is an unusual case of radiation enteritis which caused a severe sequelae of stricture in the transverse colon as a long-term effect of therapeutic irradiation for uterine cancer, and required a surgical resection.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-23653566ec09498bae8974582fe6d926",
            "input": "The patient was a nonsmoker with no respiratory illnesses.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-db14bcef339a4f2681235ba2d3c331dd",
            "input": "Antisocial behaviour was controlled in 12 out of the 13 behaviour-disordered group.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-fc0782aff369444e90be2e6126b1466d",
            "input": "A 21-year-old woman developed epilepsy, disturbance of mental state, and spastic tetraparesis during the convalescent period after acute viral encephalitis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-665b6c770d464d5c9ef168f6a6ce529f",
            "input": "Delayed recognition of intrathecal methotrexate overdose.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8ab1eaeff14e4549b17579b52f97d9aa",
            "input": "Our aim is to raise awareness of this drug, which is commonly used outside the United States, and to call attention to its well-known and potentially lethal side effect.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-716f09a013f4480c84d9ca9eef9c1ccd",
            "input": "Both infants continued on medical therapy until they reached 1 month of age.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a8777778b40e4cea9b20810c8797d2b8",
            "input": "The signs and symptoms were similar to those seen with systemic use of the drug for other ailments.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5f8097c4bc9e4ee4a0f26d82fab69596",
            "input": "This case highlights the importance of muscle biopsy in HIV infected patients whose myopathy persists despite withdrawal of antiretroviral therapy and the need for thorough investigation of non-specific symptoms in HIV infected patients who are receiving antiretroviral therapy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-9230154f7c1b406a9c54be0c18b0eea8",
            "input": "Following intravenous hydration and administration of bicarbonate, the patients' condition resolved without permanent' sequelae.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-02c195c050084c6fa31c624ccb6700e9",
            "input": "Because of its selective action on B lymphocytes, it is considered a moderate immunosuppressant in terms of infection.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-51fd99a4619e4bb5920864f7c9883d0a",
            "input": "Anterior uveitis and secondary glaucoma resulting from intraocular ointment has not been reported.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c76eee10b1b741c685c797006f3144ef",
            "input": "Histopathological features were also consistent with the disease.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d273a83af7d241e5a290606a25d82fac",
            "input": "Rush disease, or aggressive posterior ROP (AP-ROP), progresses rapidly to stage 5 disease without exhibiting the classical course that includes stages 1-3.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-20c3c5d7189b4322a34a7e39bde83128",
            "input": "After development of the tics in 2, CBZ was continued at the same or higher dose, and the tics abated and then ceased spontaneously < or = 6 months.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c892d713dbac43e7a74d39f285d8ac04",
            "input": "Diagnosis is made primarily by examination of the stool or intestinal secretions for ova and parasites.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-114309ee1d2549a0b17271d12c234b5e",
            "input": "To know the histochemical effects of steroid treatment on eosinophil accumulation in nasal polyps of AIA and the histochemical feature of a recurring polyp and to detect distributional differences between storage and secreted forms of eosinophil cationic proteins, we carried out immunocytochemical labelling with antibodies against EGI (recognizing resting and activated eosinophils) and EG2 (recognizing only activated eosinophils), and determined eosinophil infiltration in nasal polyps that were obtained before and after steroid treatment, and at recurrence of polyps.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-119d20f477784612b963c6657b02d8df",
            "input": "All eyes had subfoveal CNV secondary to AMD.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-82ed0b5978b94f26921a95fa583adab8",
            "input": "Therefore, ACE inhibitors should be discouraged for the majority of patients with primary aldosteronism, even in the face of renal or cardiac disease.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-4c9730a9fb114d9ea1cd5a243e8fbdb5",
            "input": "Two months later, hyponatremia was diagnosed, most likely syndrome of inappropriate antidiuretic hormone secretion.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-4120867ffa5d4ba8a1b4490bdf94f383",
            "input": "The patient was brought to an intensive care unit 10 hours after intake of 1200 mg mirtazapine and 20 mg lorazepam and laying outside at outdoor temperatures below 0 degree C.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-63bb840fc67e474aa809b761812e3f61",
            "input": "The process healed after surgical treatment and chemotherapy for 1 year.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-53996dd451854069b9395742ee4389a7",
            "input": "The crucial factors contributing to the deterioration of both patients in the two cases presented were the concentration of phenytoin manually infused and the possibility that their high-risk status made them poor candidates for manual intravenous phenytoin.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-2343323981b3419b8514ebb244fec26f",
            "input": "Stanozolol causes rapid pain relief and healing of cutaneous ulcers caused by cryofibrinogenemia.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-bc031efdf8fc44b49a8f6250ac3439ed",
            "input": "Panuveitis associated with multiple sclerosis complicated by cerebral venous thrombosis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3068954db93a404c886e7ae0438630ac",
            "input": "Recently, UFT has been extensively studied for colorectal, pancreatic, and various types of cancer in North America and Europe, especially with leukovorin.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d7ee07cb58fd477d8b1d1a6ea8defdc5",
            "input": "A second challenge while the patient received all fluids and electrolytes intravenously again resulted in decreased serum sodium concentration (134 to 126 mEq/L) after urinary loss of only 69 mEq of cation.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-f16518eb76184d988615ccb00d3399cb",
            "input": "Abemayor).",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c6b4d20f1907419fb74c952d883e5060",
            "input": "Both authors discuss a method of creating a postauricular pocket, burying the ear pedicle, and using costal cartilage for an inlay helical graft.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-15cfae66877c46bc9fae0a6d77b7b546",
            "input": "The other ten were given Adriamycin without this compression.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-36f76761ce4a43238c401c7799a6627a",
            "input": "It appears that this secondary malignancy was due to his prolonged chemotherapy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a76a2ee951204865ae00eea110ac23d6",
            "input": "Intrathecal application of chemotherapeutics has been the mainstay of central nervous system prophylaxis in acute lymphoblastic leukemia treatment.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-deda6d40a47c48f58705158e972a00c9",
            "input": "Introduction of the balloon into the left atrium resulted in thrombotic occlusion of the mitral valve.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-6b85e2051cb64707877783fcdcf8a502",
            "input": "The development of nephrotic-range proteinuria after renal transplantation is an unfavourable prognostic factor for graft survival.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-01ad1d5e2e764adeae6daabe5ee5e9ea",
            "input": "Due to the costs and risks of standard therapy, we decided to manage the patient supportively.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d36c85b94a1c4a09b472a44ff0ce9471",
            "input": "Adenomyosis in the broad ligament and tamoxifen: report of a case.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-13d1a14fcd064e02a23c9a0c7dddac1a",
            "input": "Three of the four patients also had bilateral ptosis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-188195742a7149d4ab9521e5d4663720",
            "input": "Daptomycin is a lipopeptide antibiotic active against multidrug-resistant gram-positive organisms.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8a33b0488820450d81596384109ee722",
            "input": "The corneal ulcer progressed despite aggressive antifungal treatment, requiring amputation of the corneal flap and daily debridement.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e14affd399e9458db387520337a1c1b1",
            "input": "We report a case of DCL that developed in the context of the immune reconstitution inflammatory syndrome (IRIS) in a man with AIDS following initiation of antiretroviral therapy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ec9d6016625a4a39b9bef69d1e15c916",
            "input": "There was no evidence of recurrent myeloma after the initial remission on cyclophosphamide therapy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-20294dc75c93428f9fbb24b3a4f9b0a3",
            "input": "So this potential drug-drug interaction could be investigated, the patient stopped taking both drugs for 1 week.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-1e42abbc374845f2bc5dcdebe55fd47e",
            "input": "Specifically, for children with a family history of gallbladder, biliary tract, liver or pancreas dysfunction, ceftriaxone may not be the drug of choice since the likelihood of complications is increased in this population.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-be919640c99b4286a78f7aa7c60711e1",
            "input": "A 13-year-old girl with acute lymphocytic leukemia was treated according to the protocol of the BFM Group (BFM-95, HRG).",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-90d0c2a4acec46b099ff88dbf683b7f5",
            "input": "She received several vasoactive infusions during her admission, including nesiritide.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3da28a83e8f14c5980efa32b5e87d9c0",
            "input": "Histologic evaluation showed massive panlobular necrosis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-523651d17722402599404cfbf5d9ff3a",
            "input": "Antitumor activity was observed in four patients.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ffd736fa352c455ea77a9802de246d44",
            "input": "Another explanation for the decreased drug levels might be an increased volume of distribution.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-f85fa942a1154680b3a1d17b6ad43f3b",
            "input": "This paralleled the rise in the number of children with tuberculous infection and disease seen at our institution, from an average 96 per year to 213 per year during these two time periods.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-7e8bbcf3b8a7439cb4e55785409c3084",
            "input": "Trying to adjust the treatment to the patient's requirements, Carbamazepine together with Oxybutynin and Dantrolene was readministrated in lower doses.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-138a92363f104e6ab60e71729352331f",
            "input": "Domestic dogs and cats may be another reservoir.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-b498501dfc544d70a2a6f6be23fc5157",
            "input": "Paecilomyces lilacinus infection in a liver transplant patient: case report and review of the literature.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-cbae8f2994e54ce789b104e548e2f33a",
            "input": "Evidence-based mental health use of anticonvulsants during pregnancy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a6b17f6c0a764573a5c02e2c1be03b4e",
            "input": "AmBisome treatment of fungal sinusitis in severe immunocompromised patient with acute lymphoblastic leukemia relapsed after autologous peripheral blood transplantation.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e691aee72b1340c1974c3bd17a945044",
            "input": "Pulmonary GVHD and pulmonary aspergillosis were also observed.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-396eaf4037274d00a13fd903c0438fec",
            "input": "The patient had a favourable outcome.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-347a39f9cdaf46e7ae78440261cf3bb6",
            "input": "Coincident with the preeclampsia was a postdural puncture headache complicating the diagnosis of late postpartum preeclampsia.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-28f75956d4f74be4bdd87ac7dea9ee6a",
            "input": "We discuss the limitations of conventional drug therapy and the lack of a sustained response to plasmapheresis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-43e83d757f0b499c84578c7e6828c765",
            "input": "Early postsplenectomy arthritis caused by penicillin-resistant Streptococcus pneumoniae.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-cac14e6fa55b433d8220061da5521b51",
            "input": "Coexistence of chronic myelogenous leukemia and chronic lymphocytic leukemia.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-94f9937ec6b14638a5e3a89304f34808",
            "input": "One week later, the patient was again extubated and 3 days later was transferred to a peripheral ward.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5fe6ae77633148c59c291a26fb4710d9",
            "input": "Three children completely recovered; one patient relapsed and died.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c34f6eb03f9b49c2a11761a451ee74ad",
            "input": "The patient was successfully managed with clopidogrel therapy during the 16 months follow-up without recurrent thrombotic or hemorrhagic events.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3acc7bbc89a5415f84a6005e6979898f",
            "input": "Bilateral inguinal scrofuloderma during steroid therapy in a patient with bullous pemphigoid.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-14f8ca6c020a45b5b610bca00da48aa8",
            "input": "This is the first report on the use of charcoal haemoperfusion for acute poisoning in Australia.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-9796b72d727743efb8e64fa74c809345",
            "input": "Lack of experience with patient reporting in real life was one of the main drawbacks in this debate.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-88e12fef82704e6b855dcf00b8ea2ba0",
            "input": "Successful treatment with partial resection of the posterior mitral valve leaflet and antibiotic therapy with cefazolin.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a2807223da294f289e9e544f1a3158d1",
            "input": "Patient 1 developed squamous cell carcinoma of the skin with recurrence, and Patient 2 developed anaplastic carcinoma of the urinary bladder.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8c28563d8c49407282b53fe29dd9f5ef",
            "input": "RESULTS: Withdrawal of oral colchicine therapy was followed by rapid corneal wound healing in both patients.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-171346151dba4deab9695d938287369e",
            "input": "Thus, olanzapine dose reduction may permit treatment continuation where this is clinically indicated.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ad7dc07bef9d4f3f9671ed0fe0e1887b",
            "input": "Action of intracoronary nitroglycerin in refractory coronary artery spasm.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-771a1bde6e894177a83b198b4ce38c95",
            "input": "Despite reduction in immunosuppression, 30%-40% of recipients progress to allograft loss.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-7317283b99a34086944fbb752d5e633a",
            "input": "In more than 6,000 patient applications of rapid atrial pacing, there has been only one failure to convert the tachycardia.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-4aa3b4118ed64c6fa32f3c4ff57fe9b3",
            "input": "Reversal of neuroleptic-induced stupor by procyclidin.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-18710b50637c49bc9fe4b2d05c54597c",
            "input": "Seven days later, she had full-blown, severe hepatitis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3a4ef2453eae4301ae0636af0b7717da",
            "input": "Therefore, contact lens wear should be discontinued to prevent further complications.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-7a6f5fb74a7248f9a5c7e4acf40e8818",
            "input": "Milk:plasma ratios were less than 1, although a higher ratio would be predicted.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-0fb8ab77245c47a68d801f9b76f021db",
            "input": "She developed a pre-engraftment immune reaction, which responded well to prednisolone, and engraftment was documented.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-28a426445a6643dda857988caae01504",
            "input": "This effect of cisapride is presumably related to its serotonin3 antagonistic property.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5312a97801264bd58b6c092605386c55",
            "input": "We report here the case of a 36-year-old man with pre-B cell acute lymphoblastic leukemia.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-290e2e928e104295a2bee5112c8a1c65",
            "input": "Seven cases of successfully treated Candida albicans cerebrospinal fluid shunt infections are reported.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e4ffceec2e854ba0b662998eee1f3ce9",
            "input": "Neuroleptic malignant syndrome (NMS) is a potentially life-threatening adverse effect of antipsychotic agents.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-515252d18e454b9789e584c21d2b358a",
            "input": "Pathologic findings demonstrated on MR were (1) chronic brain edema, demonstrable over a period of 3-14 months (proved by autopsy in one patient); (2) multifocal white matter necrosis; and (3) deep brain atrophy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-313240326db44f34ab7a0353b4e084ad",
            "input": "The patient's blurred vision gradually improved, but visual field defect remained.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-f61bffa90e1444b692d65c14db12f6a4",
            "input": "A reduction of up to 33 percent in pituitary tumor size has been reported in more than half of the 27 cases studied from four groups.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-9c5dc0c30d384fe095d37fabff883528",
            "input": "The patient eventually had full resolution of her symptoms.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-27e533a5760a443d99a0d17cf157b0fb",
            "input": "Discontinuing the oxybutynin leads to complete neurological recovery associated with normalisation of her blood pressure.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ec06c6856688490c929f2d074e86a2c6",
            "input": "The recognition of the characteristic features of the syndrome is vital since early aggressive therapy is indicated.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-225255ad5a994e11b9da895d9733da9a",
            "input": "It was characterized by hyperandrogenism and polycystic ovaries in all cases, and it was associated with weight gain and menstrual disorders in 2 of the 3 women.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-b1277ec5f02e49a39801d1f9a9cfb3ad",
            "input": "The four other North American cases are reviewed, and the epidemiology of the infection in animals is discussed.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-64e2c6835ca64b93a469894ddc4d011a",
            "input": "Two days after surgery, signs of orbital cellulitis developed in his right orbit.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-85be4fe9846c4d9689f6c710667b400f",
            "input": "Physiologic data were analyzed with an analysis of variance, with the Kruskal-Wallis test used for nonparametric data.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-68b573f0f8c24522b62807b0551d6b18",
            "input": "Cefoxitin should either be used with great caution or not prescribed in combination with aminoglycoside antibiotics.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-2c7bfa28e5514260a796458b9f20dfd0",
            "input": "We found TPO and platelet responses to be generally antagonistic through all cycles.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3bd283ef083d476f9a0b9abc2e6565bc",
            "input": "Therefore, we believe that screening for HBsAg is insufficient for detecting latent HBV carriers, and that investigation for hepatitis B core antibody (HBcAb) is essential.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-90e852a9db1343289d2b70b790c0a32f",
            "input": "METHODS: Small case series.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a74507958073477c9464b8d1b36a61ba",
            "input": "The allergological work-up was negative, except for intradermal test with gelatine.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-899cc66c3c284305b1abafe95c9df4b4",
            "input": "Laboratory investigations confirmed a metabolic acidosis (pH 7.15) and hyperchloremia.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-2428567de08043cfa5d3eac377e8f1e9",
            "input": "Churg-Strauss syndrome, or allergic granulomatous angiitis, is an uncommon vasculitic syndrome.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-cbb1216d920e46c19003643210702048",
            "input": "Pulmonary embolism associated with protein C deficiency and abuse of anabolic-androgen steroids.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e0d321a2bd4940848a091e97107f8899",
            "input": "Full recovery to pre-episode status of a quiet eye with clear vitreous was seen in all patients.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-76a2134cb1074755a01115e711b87754",
            "input": "Post-steroid septic arthritis can be treated with irrigation pump assisted arthroscopic synovectomy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-9631a045cbac4847834c083b80ae9a91",
            "input": "Incidence of myopathy in patients treated with antimalarials.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-eb7b9d2574854f2ca72cf2e750c9a24c",
            "input": "We report a 51-year-old male with adult T cell leukemia (ATL) who received a BMT from an HLA-identical unrelated donor.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ede2d9c7599a4401871e80357823f625",
            "input": "Endometrial \"sarcomas\" complicating ovarian thecoma, polycystic ovarian disease and estrogen therapy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-47c5553183b048eabc0087eb29987275",
            "input": "This may be due to a change in the type of metabolites excreted.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-6ae969bd117e4ba3b116835843ad2b1a",
            "input": "Platelet count less than SHARP: what does a case series reveal?",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8d88d2cc7fff4a20946f6d923e0aada4",
            "input": "CASE SUMMARY: A 77-year-old white woman presented to the hospital with elevated serum creatinine, oliguria for the past 24 hours, arthralgia, fatigue, fever, and bilateral flank pain.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ae1bd61ed4e348ce852e001788f475a1",
            "input": "The pathogenesis of the liver changes and their possible relationship to splenomegaly and busulphan toxicity are considered.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8582c470eb5f4ee38bef4a75e63e8d7d",
            "input": "Early data identifies atomoxetine's influence on Tourette symptomatology to be not merely equivocal but potentially suppressive in the manifestation of tics.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-042720cd8bc5434e9cb2dff105a05798",
            "input": "Serious lead poisoning in childhood: still a problem after a century.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d4eff3cea8a6477d86853f355e66f802",
            "input": "Approximately 5-6% of intravaginal clindamycin is absorbed in the bloodstream, making systemic effects possible.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ebe9e3fede714250ba06db7cd41f30e6",
            "input": "Intravenous injection of diazepam caused a rapid normalization of the EEG with disappearance of the clinical manifestations.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a747e9b0a2e542b9a33c84a6cd770298",
            "input": "METHODS: The patient was a 20-year-old woman.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a70a3d6c949d4351a1f946b087a232d8",
            "input": "In addition, 1 of these biopsy specimens also had scattered single eosinophils, unlike autoimmune hepatitis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-27ce8063f7df4393b121cc7180f71831",
            "input": "Antibodies for HIT by enzyme-linked immunosorbent assay were positive.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8ee00f4600dd4ba28d2ae72697390092",
            "input": "RESULTS: A total of 178 cases were identified.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-7cc514496ca546799faf72cb79476d0d",
            "input": "A kidney transplantation recipient 1983 to 1995, she was diagnosed with Charcot-Marie Tooth disease in 1991.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-37eb1fbc7afb4f7a9477a596557891fd",
            "input": "METHODS: Case series consisting of 3 patients treated with rifabutin were retrospectively studied.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ed77ac59461f4ebb83fc545e4b106374",
            "input": "Pulses have been given for periods up to three years without evident toxicity.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8d60d484f4aa4a4eb0b1bf26cfddc3cb",
            "input": "Despite this improvement, the patient became resistant to the clozapine titration schedule due to complaints of sedation.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-46216e22b75f40eb8704d344a8860236",
            "input": "METHOD: The case histories of three geriatric patients treated with fluoxetine for depression or obsessive compulsive disorder are presented.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-05a0144b22c845b49d39cf4ed1a32357",
            "input": "In most of these studies, the effect of acarbose (on reactive hypoglycemia) was evaluated over several hours postprandially or after oral glucose load.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-04eb7f83270d4784ae9581d03927ea1b",
            "input": "Methicillin-resistant Staphylococcus aureus osteomyelitis of the scaphoid from a catheter in the radial artery.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-733d09cf341a464a93b619794d7b067a",
            "input": "Neuroleptic malignant syndrome and lithium carbonate.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-dde430ac9feb44a8acfe42ae0b4b265f",
            "input": "CONCLUSIONS: Confocal microscopy can be a useful, noninvasive imaging technique helpful in the study, diagnosis, and treatment of Acanthamoeba keratitis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-0b1fcfe366564eac8010426f568eefbd",
            "input": "All the alternative medications for rheumatological patients are significantly more toxic than HCQ.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-6d1317202bd4446ba5d9de5848523405",
            "input": "There are very few reports about asterixis as a side effect of treatment with psychopharmacologic agents.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-00c882c9e5f54bedac1a321e3d0838c2",
            "input": "The posterior hyaloid became taut and partially detached after the third injection and was almost completely detached 1 year later.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-be196baa439e4715a51c8510bc9b7426",
            "input": "Successful treatment with dantrolene does not, however, preclude a recurrence of MH, and thus subsequent doses of dantrolene should be given.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ba12c02880f54a6dbf36c25b3fb027eb",
            "input": "Mitral valve prolapse and thromboembolic disease in pregnancy: a case report.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-591d612f203244b9b3acbb03b4f259f2",
            "input": "Successful treatment of molluscum contagiosum in the immunosuppressed adult with topical injection of streptococcal preparation OK-432.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3180dd6323564603aecacfc4579add79",
            "input": "There was no recurrence the following year.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5fbd8e5e4097440090485d3733cb89fe",
            "input": "In each case, brief periods (5 to 20 seconds) of rapid atrial pacing were effective in terminating the supraventricular tachycardia and resulted in a return to normal sinus rhythm.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-71b478dfc54f4f1da235761a8c2ab027",
            "input": "CASE: A 71-year-old man without immunodeficiency developed corneal endotheliitis in the right eye.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-fc2c9b1c221042f6ab078a2396cffdbc",
            "input": "Alternating antineutrophil cytoplasmic antibody specificity: drug-induced vasculitis in a patient with Wegener's granulomatosis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c1ace2bfbec2425aa095b4009ff4f026",
            "input": "Panic attacks occurred for the first time in a patient suffering from delusional depression during treatment with a combination of an antidepressant and a neuroleptic.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3abf844eb04d44f1a819ffe372ec8423",
            "input": "INVESTIGATIONS: Physical examination, blood and urine analyses, kidney biopsy and tonicity balance.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-59ee72bed3a649058af36ea26244b1fc",
            "input": "The purpose of this article was to provide a detailed review of the role of TNF-alpha in controlling hepatitis B viral infection and the clinical impact blockade might have on viral control.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-23a8919de3c84fd58b2518b16f45554c",
            "input": "CASE REPORT: A 64-year-old man was evaluated for chronic low-back pain after multiple spine surgeries.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3c9c50e1906c4759b5cc3d3fc38f175f",
            "input": "The skin lesions disappeared almost completely within three months.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-38a17694934244b388f1c65af14f61fb",
            "input": "These agents have potent cytotoxic and immunomodulatory effects and are useful in the treatment of a variety of conditions, including inflammatory bowel disease.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d0c523156a984230a51397240d65ddac",
            "input": "We observed a 7.0% prevalence of QT, prolongation among all patients screened.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-97f14c4f08a94a37ac3fe909e4111c6a",
            "input": "Hematologic evaluation disclosed pancytopenia: red blood cells 283 x 10(4)/mm3; white blood cells 700/mm3; and platelets 8000/mm3.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5d2a927d6812469091eac1f79a712466",
            "input": "On discontinuation of the drug, serum CK concentrations returned to normal within eight days.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5cb2cfafb99d4e8fab7f8cd4759c603d",
            "input": "The etiopathogenesis and management of this condition are presented.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-f911d7f7399346a2a7194dc777962502",
            "input": "We describe a 49-year-old woman who presented in 2002 with pure red cell aplasia (PRCA), systemic lupus erythematosus (SLE), and idiopathic portal hypertension (IPH) that developed following a thymectomy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8f11605d1dde4087bd91dc227df43238",
            "input": "Formation of these plugs was probably due to extensive tumor necrosis at the level of the walls of the major uterine veins, which resulted in an open exchange of tumor plugs to the vascular spaces; decrease in tumor tissue coherence secondary to chemotherapy may have further contributed to the formation of tumor emboli.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e2973183ac254e02b2165ca1207a30ce",
            "input": "Improved awareness and rapid treatment of the second patient had a favorable outcome with no sequelae.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-72ef51d8805f4e8f95fddfa2a41b2a96",
            "input": "The patient responded promptly to appropriate antibiotics.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-f239ed68d58b45129043639958659ef7",
            "input": "In clinical practice, serum level monitoring of anticonvulsant drugs is usually adequate.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-2b5e206dbcff4d28b071571cc1c68408",
            "input": "Medical management of the head and neck cancer patient (HNCP) most often will include radiation therapy to the head and neck region.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-0765cc83b514493abf9f3556173e2af6",
            "input": "Further research and better communication among health care professionals are needed to determine if prophylaxis can reduce adverse ocular events.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e40c6fcd1266424e8670625b3a750ac5",
            "input": "However, brain metastasis was diagnosed.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-63d5e570284f4a7dbd82a676a313a39f",
            "input": "One was alive with no evidence of disease at 14 month follow-up, while 2 had residual disease after bone marrow transplantation and died of complications at 4 and 5 months after transplantation.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-4551e967400048e2993211242f8b3325",
            "input": "Blood transfusions worsen the evolution of this peculiar form of HUS.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e4b46a0bf9364d94beed36264efa54bc",
            "input": "NMS must be considered as part of the differential diagnosis of fever in burn patients receiving medication known to cause the syndrome.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-80ae2e6d03e44aaba9996d0725b1debc",
            "input": "They were both treated for stage IV neuroblastoma with chemotherapy, bone marrow transplant (BMT) conditioning that included total body irradiation and RA therapy after BMT, although the patient in case 1 had established renal insufficiency prior to the commencement of RA.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8cc672c9ae0348ada6be15b7240e6c0a",
            "input": "No re-occurrence of pancreatitis was observed in a 16 month follow-up.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c5d0c523e1d3483ea39ee5b0ce2416e0",
            "input": "Tests for antimyeloperoxidase ANCA were repeatedly negative before the drug was started, strongly implicating the drug as the cause of the episode.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-347bed46f2ac4462a4ea0c4a7c97eefc",
            "input": "Acute cervico-facial oedema and loss of consciousness following ingestion of barracuda fish.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-4cb83e48a7954722ba7781aed0bbc578",
            "input": "Crohn's disease has not been associated with its administration.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a885fe9b0ca444dab20f455779de5a4e",
            "input": "Digoxin serum levels and toxicity risks increase with the addition of amiodarone.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-f347f882dc804f04b43927f732fccf5a",
            "input": "Accordingly, a practical and safe approach to MAOI dietary restrictions remains an essential component of patient management.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-19ef9308d0c84272b185e3d5c69d44d0",
            "input": "Along with normal results of a hepatorenal panel and normal serum vitamin B12 and folate levels, no metabolic or endocrinologic alterations were present to explain the nail pigmentation and dystrophic changes.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a8a0425657eb4a678d6f0b089b9f181e",
            "input": "The patient recovered without sequelae with conservative therapy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5b62ab51789d45b9a3b72b719b3eb66e",
            "input": "In a fifth case a 14-year-old boy developed papilloedema after taking a short course of tetracycline for bronchitis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5a22ff4fed2c4e7f8b9d09a42718b637",
            "input": "Reinstitution of intravenous anticholinergic medication provided relatively prompt relief.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-559a6286f78f4e7785a34d00e1c63ccf",
            "input": "Hematochezia subsided with conservative treatment after a discontinuance of Kalimate administration.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ef4a66235d554d71b4108a0d51299827",
            "input": "A spinal haematoma occurring in the subarachnoid as well as in the subdural space in a patient treated with anticoagulants.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3b59e80c0e104c0a9be51c478c8eee80",
            "input": "Propranolol had to be given for eight months after surgery.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-f058ca13aa4e4db2a44c65079ce14aa4",
            "input": "He developed rhabdomyolysis with hemoglobinuria after 2 weeks of treatment.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-9effbfa0127e4478bab47d6037d219d2",
            "input": "The additional finding of extensive resorption of the outer cortical surface and bone formation at the inner surface suggested a reversible phase after discontinuation of treatment.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-42d3c25c1804480c990e6e43d6918707",
            "input": "The patient developed unusually severe hematological toxicity to chemotherapy as compared to nonsmall cell lung cancer patients without the GD defect.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-dac2f8ba30084e04821d70b4c851b3fb",
            "input": "The five human eyes of three patients have shown no evidence of intraocular toxicity with a median follow-up time of 3.6 months (range 2.0-6.4 months).",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c09e9ff9482645619040ae4da12e8b2c",
            "input": "Patients who develop these reactions whilst receiving GSTM can be successfully changed to aurothioglucose.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-47c94e54e9b1479ab8c77e58d514867e",
            "input": "Furthermore, pleiotropic effects of ACE inhibitors are unlikely to provide significant benefits in the absence of blood pressure reduction.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-b44cab36a1af44878f1fdb2106cf23f1",
            "input": "It is used alone or in combination with other lipid-lowering agents in the treatment of various forms of hypercholesterolemia.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-06caa09ffc9f40aa8a6701ce6d981bf5",
            "input": "An increasing range of drugs have been reported to cause sAML, including the alkylating agents, the epipodophyllotoxins and the anthracyclines, both as single agents and in combination (Pedersen-Bjergaard & Philip, 1991; Pedersen-Bjergaard & Rowley, 1994).",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ca2c06dd9f304686b618bba27ff1b2e4",
            "input": "A skin biopsy specimen revealed microscopic, sterile, neutrophilic abscesses.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-f68822a2f24241a19f6ce8a00eae8306",
            "input": "HNCPs with malignant disease require judicious dental treatment planning prior to radiation therapy (RT) and/or chemotherapy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-916d63e336bb4097bb1473bd282f10b4",
            "input": "The child died 62 days after discontinuation of prostaglandin treatment.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8114281ee5cd487c8c587d8d1e3f55e9",
            "input": "Parkinsonian features were progressive, even after the patients had stopped work.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-86e05d1742614702ba629b76588660d9",
            "input": "Adenomyosis confined to the broad ligament is extremely rare.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-23dbbbc882ba47aaaec0e877c47e9873",
            "input": "The most progressive neurological deficits like severe tetraspastic paresis, were seen only in the nondialytic renal insufficient group (3 patients), while the others had a more benign course of the disease.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-7780f6a89fae46aca612770b1fa0a1e2",
            "input": "Clinical recovery required an average of 42 days and was complete in four of five patients.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ee5e0e4d46b746d4a35bc83cd8c829ef",
            "input": "Another enzyme catalyzing the metabolism of antidepressants is the polymorphic S-mephenytoin hydroxylase.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3b263cbc171646f289f7e9820272c957",
            "input": "In this report and other reports describing successful resuscitation, the total dose of sodium bicarbonate is conspicuously higher than in reports describing extracorporeal interventions.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-39270f95e4a44877af778f2ef7515fc9",
            "input": "Trichosporonosis appears to be an emerging fungal infection among immunocompromised individuals (including both hematological and solid organ transplant recipients).",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-31b4e959bb53448aa7632d38382c0725",
            "input": "Both the psoriasis and the HCL cleared.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3e6d1388ab9b4724bd56c40f802c4aeb",
            "input": "He was hyperthermic (oral temperature 40.6 degrees C), diaphoretic, tachycardic (heart rate 140 beats/min), and tachypneic (respiratory rate 22 breaths/min), with severe muscle rigidity and shaking tremors.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-cd84a2df33f94f0d80966f82e9fb7161",
            "input": "Previously reported cases are reviewed.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-18edbab6b08e4a89ab7c3f01dd58d928",
            "input": "He was taken to the emergency department and given intravenous methylprednisolone sodium succinate and intravenous diphenhydramine hydrochloride.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ff7318b38a3e453da270de927ef7dd3b",
            "input": "Neuroimaging shows bilateral subcortical and cortical edema with prominent posterior distribution.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d7e112d69dd64543925679d8f848efa5",
            "input": "All patients experienced severe anaemia after induction chemotherapy despite erythropoietin.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-9b66790593794227a34f4ca1051dd63f",
            "input": "Both patients underwent successful thrombolysis after super-selective angiograms.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-2dc65308e11347079a73ad0c60be6843",
            "input": "Bilateral Acanthamoeba keratitis with late recurrence of the infection in a corneal graft: a case report.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-69f5803fd204413683591a1e5cffeedc",
            "input": "In 2 cats, rebound hyperglycemia was diagnosed on routine serial blood glucose determinations.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-74f730f4019a44f9b91f1bda1f845082",
            "input": "Post-transplant lymphoproliferative disorder (PTLD) in the central nervous system (CNS) has a poor prognosis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-abbde1d3f7a44e6580fd5ad41d3d21f0",
            "input": "Isoniazid and vitamin B6 were co-administered with adalimumab.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-707674aa1e114efcb7846e9847b76995",
            "input": "This case report represents the successful usage of LS for weaning from cardiopulmonary bypass circulation after coronary artery bypass surgery.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3496f19b69f8479d92d7af8b6fb5526c",
            "input": "OBJECTIVE: We describe the prolonged clinical benefit of murine chimeric antitumor necrosis factor (TNF)-alpha monoclonal antibody, infliximab, on pediatric patients with Crohn's disease and ileal pouch anal anastomosis (IPAA).",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-367ccdd5c6ae44678b75c5c64762516d",
            "input": "We describe the development of severe lipoatrophy in a patient treated with biphasic aspart.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-aed6d0337378420d94444ab5c1db38dd",
            "input": "Although preemptive therapy with ganciclovir prevented successfully severe CMV diseases and CMV-related mortality, a patient developed persistent positive CMV antigenemia for more than 1 year after transplantation and CMV disease, despite the use of ganciclovir and foscarnet.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c2a8be26f79148a88a64d616174879b3",
            "input": "A 59-year-old female was admitted to Tsukuba University Hospital and diagnosed as IgA-lambda multiple myeloma (stage IIIA).",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-77f4ab4413d24c5f8166ddc92bc41310",
            "input": "Severely elevated serum lithium levels were found.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-45f2f10b06d54c7faa832369e2c4893a",
            "input": "Pseudomonas spp. are of increasing importance in human immunodeficiency virus-infected children causing significant morbidity and increased hospitalization.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-0aeb9022cdb44fd789f21367d286a3c7",
            "input": "Colonoscopy revealed a Dukes Stage B colonic adenocarcinoma.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-da012aefb1e545f99ffbb04c1bb5c3d3",
            "input": "Acute chest pain is a common presentation in emergency.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ea34368a225e4314a8bf2654fd4cebf8",
            "input": "The mechanism behind this observation may be similar to that of previously reported protease inhibitor-associated fat redistribution, but instead involving the adipose tissue of discrete uncommon benign tumors.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5e1ec9f0967248eba0e76f1a4d622e39",
            "input": "In contrast, newer North American guidelines have focused on the severity of illness of community-acquired pneumonia.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-aa0d2b8e70544a4e91a3ee7d4e9717ac",
            "input": "At explant, all four systems had clots adherent to the surface of the tubing and connectors on the pump outflow side of the circuit.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-2c07935d3d014d4295bcdd4604ed5355",
            "input": "Unusual side-effects due to clobazam: a case report with genetic study of CYP2C19.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-b405f5b423094b91952defa23fce7e15",
            "input": "Two days prior to admission, metoclopramide 10 mg orally three times per day was started for a gastrointestinal condition.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-2ee0885ce3d34672b250ba69907e18aa",
            "input": "In both patients therapy with high dose acyclovir, 10 mg/kg q8h, intravenously, was instituted based on clinical presentation.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-9f88563725f1485fbc67bb18648eddb1",
            "input": "OBJECTIVE: To discuss the various diagnostic and treatment options that should be considered when managing parotid duct injuries that result from skin cancer extirpation.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-cde7138207c842b0b3e944c1b883e73a",
            "input": "Nausea, vomiting and acute pancreatitis were also observed in one patient.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-01e0a352db1b434da176e8bc24d52663",
            "input": "The combination therapy of interferon alpha and ribavirin was given to a 50-year-old female with CHC who had not responded to a previous treatment by interferon alpha.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-7d3c458137104a35bd372b22e6fed8b0",
            "input": "INTERVENTIONS: Treatment with aspirin and prednisone in one patient.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-eb56d2b2e7874aae939ec91dd928893c",
            "input": "The reaction subsided after treatment with diphenhydramine and dexamethasone.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-cfb134fc110b45d0ab0b5ae5ade4a4be",
            "input": "These observations add to the literature on pro-arrhythmic effects of commonly used antiarrhythmic drugs.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-978899f0df234993ae72014d160f7baf",
            "input": "Three such patients are described whose main features were uncontrolled seizures, progressive dementia, behaviour disorder, muscular pseudohypertrophy, and a relative paucity of localizing neurological signs or signs of raised intracranial pressure.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-26973609c06a41209c2b5b41d7c16401",
            "input": "Three patients (APML = 1 and ALL = 2) are still alive and disease-free.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c6e6d4c0c6704798ba979f34fa4b72bc",
            "input": "We describe a patient in whom this was the primary manifestation of drug hypersensitivity.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-0baf27122d9444f298ae0699c50ddf76",
            "input": "We therefore strongly argue in favor of extended screening recommendations for infectious diseases including viral infections before considering a therapy with infliximab.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a0112025daf745ac868c6aabc156dc7c",
            "input": "All patients improved rapidly after discontinuation of 5-ASA compounds.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a1e1cd70e95743e582bfffaa946fb5a0",
            "input": "Recently lamivudine has been reported to be effective in suppressing the replication of HBV under such conditions.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-fa98cf1723364334aa083d4700f9e4d5",
            "input": "OBJECTIVE: The aim of this study was to evaluate the present status of surviving patients 10 years later, together with the latest clinical and histological data on patients who had died.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e603a1b05abd4b589403fdab1a6476da",
            "input": "At postmortem examination, the characteristic microvascular lesions of the hemolytic-uremic syndrome were found in the kidneys.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-23ecfd7351094ce2af101d64e2106bb2",
            "input": "Single and multiple verrucous plantaris lesions are well known for their resistance to conservative methods of treatment.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-7833b1ac156a473fb0feed49dbb33a92",
            "input": "Its treatment is mainly based upon discontinuation of heparin therapy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c4214ef279ee4f32b34d9c98dee46962",
            "input": "Development of malignant breast microcalcifications after neoadjuvant chemotherapy in advanced breast cancer.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-7ecda7d8a939466d9b541bbd6000506f",
            "input": "We report a case of graft versus host disease after liver transplantation in which the diagnosis was made by short tandem repeat analysis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-29242a01d76c4ddea50da27d68debfb8",
            "input": "Copperhead envenomations in the Carolinas.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-77308e56417c4d08b184f03636dccf35",
            "input": "Severe hypertension in newborn after pyeloplasty of hydronephrotic kidney.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-f320a200c6814c99a49a694397ec895e",
            "input": "CASE DESCRIPTION: A 24-year-old 732-kg (1,610-lb) pregnant Belgian draft horse mare developed neuropathy and signs of intractable pain following colic surgery.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-89cd201874614e599344e2bb613cb3d0",
            "input": "TEN is a disease of both children and adults, but TEN in early infancy is a rare event; only two well-documented cases in infants less than 6 months of age have been reported.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-7e0961400e684819afc866264cc16d6b",
            "input": "Reversal of CNS-prophylaxis-related leukoencephalopathy after CSF shunting: case histories of identical twins.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-0394a7c60a4f40afbb10a8d81f698b0a",
            "input": "Recently there have been concerns relating to liver and now kidney toxicity.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-edcc26bda382448bbcc144e8da9f5df9",
            "input": "CASE REPORT: We present cases of 10 patients with Type 2 diabetes mellitus who developed acute renal failure and severe lactic acidosis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-402556f8a5dc42a487d89bb999e1c865",
            "input": "Findings from biopsy specimens of skin and jejunum suggested a cell-mediated pathogenesis, and lymphoproliferative studies of the patient's mononuclear cells revealed a positive response to phenobarbital.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-35c217ae082745528149695b991be15f",
            "input": "CONCLUSIONS: JHR should be an anticipated reaction to early doses of antibiotic treatment for treponemal diseases, such as syphilis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-98000edae4334136afad6fcc65b4db80",
            "input": "She was transfused with four (4) units of packed cells and Zidovudine was replaced with Stavudine.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-fd96ae9950754e378048b73e48cfb56e",
            "input": "Electromyography, muscle biopsy, and the course of the patient's illness were consistent with polymyositis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8a1af550c5b6427c941a87a49d92bc62",
            "input": "The development of a rifampin-impregnated silicone catheter yielded excellent results in infection prevention and treatment in vitro as well as in an animal model.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ea81aa94a1e44163910e0ea1d91d474b",
            "input": "We review the medical literature about mucormycosis peritonitis which, albeit rare, carries very high mortality.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-f53d7d50fe0741fc8b6b28fe4ed879f1",
            "input": "Complete regression of the CIN was observable after 60 days of therapy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e61b02afb00a4924a392ace226c0db6a",
            "input": "Rush oral desensitization with Viokase solution was attempted, starting with 5 mg, and the dose was doubled every 20 minutes, aiming to reach a cumulative dose of 700 mg.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-bd222517cf8b45749e8f479acee2d27c",
            "input": "The infiltrate was treated with a combination of topical polyhexamethylene biguanide, chlorhexidine, atropine sulfate, and oral itraconazole and resolved within 2 months.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-44b35b7d86a64f159955c2e738d0b1cf",
            "input": "A 67-year-old man on long-term carbamazepine therapy underwent elective coronary artery bypass grafting.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ce68b015a6d3468cb1654e7e0ba045b8",
            "input": "A 55- year-old man had been followed for chronic hepatitis B infection for 10 years at another institution.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-47e6f55dfe514d25b9d26f363711af35",
            "input": "The first was a 56-year-old male treated with multiple chemotherapeutics for multiple myeloma.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-b2f502e8ec6245039b4039230801c8a3",
            "input": "Beneficial late administration of obidoxime in malathion poisoning.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5fb5ea55f59d402383670cc6f49fbb03",
            "input": "These areas were subject to repeated exposure to solvents.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c520f224f7c94a4ab04cd93b5cf3471f",
            "input": "Initially, she responded well to corticosteroids, but relapsed when medication was discontinued.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-90ccb8bee9444b86b1be4602d3f72cee",
            "input": "We describe a preterm infant with severe idiopathic respiratory distress syndrome (iRDS, hyaline membrane disease) who needed artificial ventilation with high inspiratory pressure, high frequencies, 100% oxygen and developed a symptomatic patent ductus arteriosus (sPDA) in the course of the disease.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d4e00feaafb741b5983f0b584a3a526f",
            "input": "It is important that nurses understand potential side effects of these agents, know of possible interventions, and participate in research to identify effective interventions.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-98fd28b80cf94f53acf24bf69e105403",
            "input": "The patient was also found to have Hashimoto's thyroiditis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-9f689f8ae4714977a6470e3abcb74743",
            "input": "Neither a complication nor clinical or radiological sequelae occurred in this patient.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-2be30ba75fa34c6095ff2d55e33415e7",
            "input": "Twenty-four to seventy-two hours following the switch, all patients developed intractable headache, despite the use of different symptomatic drugs.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-253383970dcc473fb35d41f7f3842844",
            "input": "It has also been seen in people with gastrointestinal diseases with malabsorption.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-189463981b67474490a73a7e0f98f5bc",
            "input": "The clinical course of a 9-year-old diagnosed with attention-deficit hyperactivity disorder, obsessive-compulsive disorder, and Tourette's disorder and treated with a combination of methylphenidate, clonidine, and fluoxetine is described.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-100be7d85c514b81ba488e051741c0dc",
            "input": "Power spectrum analysis studies revealed that heart rate had significantly improved and that power spectrum cardiovascular parameters had returned to normal.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-29c728fd1a5449ecbf66ffa6cc61e54a",
            "input": "The authors report a world class runner who sustained a rupture requiring surgical intervention.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c36a67236ca4414ca568d7adb7bfc434",
            "input": "Aromatic antiepileptic agents, such as phenytoin, carbamazepine, and phenobarbital are the most frequent causes of this syndrome.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-68114ebb62b54398827e2a32e4887057",
            "input": "Radiologic findings were consistent with PI.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-9a0c0169bb56463280e8553ad07b4b4c",
            "input": "A periodic examination of the nasal septum should be undertaken in patients with ABPA and rhinitis on long term inhaled oral and intranasal corticosteroids along with oral corticosteroids.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-076441cd29db4c6cab08c8a540ac1353",
            "input": "We present a case of accidental injection of tranexamic acid instead of bupivacaine during spinal anesthesia.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a8608726c0b047008514f340a767dddf",
            "input": "Patients experienced a mean reduction of 92% (a mean drop in frequency of 21.7 to 1.7 episodes per week).",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-1a8b6c5bb6554785b1d0537ee7d7fedd",
            "input": "TB should always be considered as a possible diagnosis when treating febrile immunocompromised patients.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-fedddb88442e4904aeec35ca7615b12b",
            "input": "Asthmatic medications can place the patient at risk of dental erosion by reducing salivary protection against extrinsic or intrinsic acids.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-cc2c343b9c5a46a1ab19f9707cb8b190",
            "input": "The duration of the pauses were equal or almost equal to one short plus one long P-P interval or to twice the basic sinus cycle.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d33620c8ff904cd0967e7ffa0a4496d2",
            "input": "Imatinib mesylate therapy in patients with gastrointestinal stromal tumors and impaired liver function.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ba66f4a163464d42919a6d029d2df8ae",
            "input": "Over the next 15 h she developed progressive hemolysis and methemoglobinemia.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-eefb767393a94970b83ffffb69bd2e71",
            "input": "She subsequently developed a classic varicella rash, sever back pain, rapidly progressive hepatic failure, pneumonitis, and encephalopathy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-002b0ab35dec4e1bac3178e171d43322",
            "input": "Due to the difficulty in identifying and verifying exposures to such agents, only a few chemical compounds are clearly linked to malignancies.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-1fd3b790f9654d35b20420071aefd669",
            "input": "He had experienced subarachnoid hemorrhage (SAH) from a left vertebral dissecting aneurysm, and had subsequently received a ventriculoperitoneal shunt against post-SAH hydrocephalus.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e1ef9942128a432b8134a8fc6f01fe61",
            "input": "Different reasons for the RPE atrophy such as collateral damage of the choriocapillaris with a subsequent secondary RPE atrophy, a direct photochemical effect due to the early localization of the photosensitizer in the RPE, or a depigmentation or photobleaching of the RPE, which led to a window defect in the fluorescein angiogram without loss of the major functional properties of the RPE, are possible mechanisms involved in the development of the documented lesion.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c3048be9eab94f7e9075d47aa1aec8d9",
            "input": "The kidney function returned to normal within 1 week.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5ae26f12af9843ce97c7d6df0beb266f",
            "input": "Record et al. have recommended oral loading in selected patients.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e99c3037090b42938dbd92ce598cb064",
            "input": "Since continuation/maintenance ECT is not well established, prophylactic therapy in recurrent illnesses is more commonly carried out using antidepressive medication alone or more often in combination with lithium.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-6241a71669224122b8d6747ccd005362",
            "input": "Furthermore, therapy with dantrolene has been demonstrated to be beneficial in the treatment of MH associated with diabetic coma.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-85039fed8f264dd0b5a218cd1f77edab",
            "input": "CONCLUSIONS: Topical imiquimod 5% cream seems to be a useful treatment for eyelid nodular basal cell carcinoma in selected cases, but further long-term studies are needed to assess the efficacy and safety of this approach.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-287237555c38404685c422cc2793dfb1",
            "input": "PURPOSE: To review the current literature on suspected green tea-related hepatic reactions and to describe two new cases reported within the framework of the Italian surveillance system of natural health products.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-35970fbac6414b82b986baeec0122b01",
            "input": "High-resolution CT (HRCT) findings of this disease were compared with the pathology.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3730b8994b32415696a5d6a973713ae7",
            "input": "Continuous subcutaneous infusion was well tolerated and about 80 per cent as effective as intravenous therapy in chelating iron.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-597962ea6fe84986b3e7fa8e0fa778de",
            "input": "Migraine prevention.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5493eb5c0f524a1793aa039ab6e53476",
            "input": "Cutaneous lesions resolved two weeks after the drug was withdrawn and topical steroid treatment was instituted.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ab6fd98e659c4eefb3361c546e537c60",
            "input": "Pure red cell aplasia (PRCA) is a rare complication after ABO-incompatible allogeneic stem cell transplantation, but its mechanism is still unknown.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-63944ed555224df8bb41ee983503ba6d",
            "input": "It can also be used to treat hematuria through its action on decreasing urinary fibrinolysis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-42843cf6d6ea4c2ca367cce232310e35",
            "input": "OBJECTIVE: We identified a group of patients with rheumatoid arthritis (RA) who were sensitive to both the beneficial and the side effects of intramuscular (im) gold treatment and whose disease was well controlled with doses of gold between 2 mg every 6 weeks and 5 mg weekly.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-133f401d311f43ce81b2dc5356135ed2",
            "input": "Photo-onycholysis associated with drugs is an uncommon disorder.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-9835f8ca91e248678781beced126a716",
            "input": "Those side effects that occurred, predominantly iron deficiencies, hypertension, and hyperkalemia, were controlled by appropriate clinical management.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-aae9b6afdde542ffa0b6f2fbc0d526fa",
            "input": "We followed these patients by A scan ultrasonographic ocular measurements, documenting reduction of the anterior chamber depth combined with lens thickening.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-1e56d9fe2b0a43349cea254836a9bd1b",
            "input": "We present a patient who developed extensive Molluscum Contagiosum (MC) lesions shortly after being started on HAART.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d04cb324abee46ebb4bb4c34bb8ff26c",
            "input": "In the case of foul drainage, burn reconstruction would be delayed.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-4cf733a2fdb3480d83e4aab30d3e1000",
            "input": "This is not a controlled study but an anecdotal experience that resulted in improved outcomes in a patient with multiple allergies, including iron dextran.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-0b06683b1a3849df9e2ec08ce3bd04dd",
            "input": "All-trans retinoic acid has revolutionized the treatment of acute promyelocytic leukemia, but this therapy is often complicated by the all-trans retinoic acid syndrome.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-456c658087c14d2fb890d3625c83931d",
            "input": "We present a case of disseminated cryptococcal infection in a patient with pemphigus vulgaris treated with high dose corticosteroids as monotherapy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ffe52dd062904698a4537d8894248f5d",
            "input": "Effectiveness of spray application of ACNU in the local control of malignant gliomas: report of two cases.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-fddc083f9d2f44058ceb1016c7a1ab3b",
            "input": "They represented a typical picture of NE: two of them died because of septic shock; five patients had subileus with irritation of the peritoneum; and one had hepatosplenic abscesses confirmed 6 months later by post-mortem examination.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c245f4530d5d4927bf434fd67448fd98",
            "input": "Proposed mechanisms for leukemogenesis are presented.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-16262eb16c9c484fb9e441537f57a3e9",
            "input": "Whether the drug is unmasking latent autoimmune hepatitis is unclear.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-cfc4f11866204f18b9faf2306f30166d",
            "input": "The patient was treated with intraventricular and intravenous vancomycin, intravenous teicoplanin and oral rifampicin, followed by oral chloramphenicol and rifampicin.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c6ea2bca499c4c0fa568a1a11bff183a",
            "input": "The timolol was discontinued, and the patient's heart rate increased.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-1e0eae0185164665850f94511562d1aa",
            "input": "Although the current metabolism of the 2 drugs in combination is poorly understood, the potential for serious interactions seems to exist in the rapidly growing population of persons with asthma, for whom they may be prescribed.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3ef9b045b7ee4dd19e24943bd43b1c59",
            "input": "It is extremely resistant to standard treatment, and confers a poor prognosis for this disease.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-cce8b2b1b24f4a7d829b1f82051149f5",
            "input": "Her medical history included vascular dementia accompanied by depression, arterial hypertension, and heart failure, as well as cardiac pacemaker implantation several years earlier for severe bradyarrythmia.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-81746c66c762495d942767a55750a6b3",
            "input": "CONCLUSIONS: Photodynamic therapy for cholangiocarcinoma is safe and technically feasible with a preloaded biliary catheter and a monorail technique for catheter positioning.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5146edaa9ff649ecb9500c28478b9d92",
            "input": "There has been no further recurrence in the long-term follow-up.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-0496c9bc05694088bc012821699664ca",
            "input": "Some hiccups are associated with certain diseases or occur postsurgically, and life-restricting intractable hiccups should be treated.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-2d015be6701b44a2968cd6353b7bdcd8",
            "input": "The patient was successfully treated by discontinuation of cyclosporine and mycophenolate mofetil, initiation of systemic amphotericin B, and aggressive surgical debridement.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-114fdb1d5a174a16af3fab878d0871cb",
            "input": "It is severe enough to require discontinuation of therapy in 1-10 percent of patients.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-9e9217d03b7a4a8a8140d8c9a5c46714",
            "input": "The lesions resolved completely approximately 30 min after removal of the hands from water.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-57cb98d4a0bf41c7b2d955c77c316372",
            "input": "Here, we describe a case of Epstein-Barr virus-associated polymorphic PTLD that developed shortly after treatment for cytomegalovirus reactivation in a lung transplant recipient who was preoperatively seropositive for both cytomegalovirus and Epstein-Barr virus.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-cfd05fd5dcea4764ac72c5115291155f",
            "input": "Our experience of this case led us to conclude that: patients with pulmonary metastases may develop bilateral and/or recurrent pneumothoraces following chemotherapy; computed tomography scan is essential for defining the cause of SSP; and closed chest tube drainage remains the therapy of choice, while chemical pleurodesis may also be used to prevent recidivant SSP.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-61cc96c7a5984d6781f2e61793df9def",
            "input": "MR appears to be valuable in the detection of abnormalities induced by treatment with high-dose methotrexate.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-7319877ddf054d47a9e539d47b33760e",
            "input": "The primary goal is to identify and treat the underlying disorder, while minimizing the impact on hemoglobin (Hb) levels.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-f9e43c65961142edb0752fc13b0749f2",
            "input": "A case of mixed adult Wilms' tumour and angiosarcoma responsive to carboplatin, etoposide and vincristine (CEO).",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3f3f2aef540e4fa785b6b6ed310f43b0",
            "input": "Diffusion-weighted MRI (DWI) may help to distinguish between ischemic stroke and chemotherapy-related leukoencephalopathy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a726f745ac244bc59ae7c8470ac72380",
            "input": "Ischemic cholangitis caused by transcatheter hepatic arterial chemoembolization 10 months after resection of the extrahepatic bile duct.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-200d6e39430e484090e0f78da24376df",
            "input": "DISCUSSION: Two patients with hypothyroidism had remained euthyroid and stable while receiving 1 levothyroxine product, but became symptomatic with dramatically increased serum TSH concentrations while receiving what were thought to be comparable dosages of another levothyroxine product.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a05773252c72442da920bce2caf499bf",
            "input": "Although weight gain often coincides with hyperglycemia in patients taking atypical antipsychotics, it does not seem to be a necessary causal factor.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-74337d42eae14330b4093c7c1e206f0b",
            "input": "Symptomatic cluster headache related to ocular pathologies have been rarely described.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-962f6f7d3ee44e63b792de1598d17d2e",
            "input": "Laboratory studies showed leukocyturia, thrombocytopenia, severe anemia, and tarry stools.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-b7e27b7caa9e44ab97571c31c1af8d01",
            "input": "Classification included dry (7%), mild (48%), moderate (39%), and severe (6%).",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-19f60e69c88346feba93a52b150eb620",
            "input": "PURPOSE: This paper reviews five newly diagnosed cases of DM type 1 in Israeli Air Force aviators that presented over the last 15 yr.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-fafce6835f1148ab89a4700ebbbb83d6",
            "input": "Treatment was given as direct observed therapy (DOT) and sputum cultures, blood chemistry and neurologic examination were undertaken on a regular basis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-fda8303fe5764df29be837da198e685a",
            "input": "The nocturia was defined as having more than two episodes of urination during sleep per night on average.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-b896ff4378b8460fbce45c8b69de8fc5",
            "input": "Because of her severe symptoms, mifepristone was administered for a period of 19 days.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-6105ef16d65a42c79d4ff394de826918",
            "input": "Both the clinical picture of the patient as well as laboratory, imaging and histopathological findings may help in the diagnosis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-16a060e2b41f44abac8afb76fd1f783a",
            "input": "Another approach involves minimal debridement of the cartilage and letting the wound mature for 6 to 8 months.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-41f4bbb5aa7d4855b8e5a1f345d9a5e2",
            "input": "RESULTS: A complete response (CR) was obtained for all three patients, resulting in a response rate of 100%.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-f1b1dd6fd51a4b78ac664c40995ba08f",
            "input": "Pigmentary aberrations are well known side effects of cytostatic chemotherapeutic agents.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-7b66c3b8cd7a4a759941f667e1e911e0",
            "input": "At this writing, few cases of nondurally based intradural meningioma have been reported.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-2ccfe7b1db2a4955b78ccd1fd4ca4c1d",
            "input": "Immunosuppressive treatment of rippling muscles in patients with myasthenia gravis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-aa21283086d3427898d2ea562888f999",
            "input": "Patients at increased risk were those with severe disease and taking concomitant MTX and corticosteroids.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-b25b264882fd4ff39609b4ab1d28c331",
            "input": "These organisms are, however, sensitive to vancomycin.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-391aafe00d4b456e9c2303bc22e329dd",
            "input": "A 9-month-old boy with progressive hepatosplenomegaly and neurodevelopmental delay was studied.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-4d4461bfec13472e96c5f5a8a395f8a9",
            "input": "MANAGEMENT: Thalidomide withdrawal, dexamethasone maintenance therapy, monthly oral courses of combined melphalan and prednisone, salvage therapy with bortezomib.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-9952cbe5da7841d49c7051211825a43b",
            "input": "Symptoms mimicking Crohn's disease deteriorated under intensified immunosuppression and surgery.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-63946623ef78435c8da26acfa42819d3",
            "input": "In all cases SMS 201-995 treatment has been well tolerated and has few side-effects.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-6f2428d33cb94a08b6be9fff617c3f94",
            "input": "The use of such chemotherapy regimens in Ewing's tumours should be carefully considered, particularly when radiotherapy encompassing the spinal cord is an essential component of management.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-bd52ebf51155438aa71e98acf5f61770",
            "input": "Sudan IV staining indicated many lipid droplets in follicular cells.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ca5603fd8fe346aaa0f38d6cf179c7a5",
            "input": "Successful treatment of postoperative pyoderma gangrenosum with cyclosporin.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-266b60c242874437ba4bda29f63fee69",
            "input": "We report for the first time on a patient who had isolated aspergillosis of the small bowel after autologous stem cell transplantation.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-1b975de006e248999447033018cea02f",
            "input": "This report presents a patient with membranoproliferative glomerulonephritis (MPGN) who developed KS following treatment with long-term medium dose glucocorticoid and short-term additional immunosuppressives.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e5dc85f50d2f49a79257218b32f12c81",
            "input": "As compared with an expected number of 0.04 cases of acute myeloblastic leukemia based on patient-years, the observed seven cases correspond to a 175-times increased risk.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-cd2b0e7ee1fc4891b66bc25ca7d4d065",
            "input": "A 55-year-old woman with systemic lupus erythematosus was admitted with fever of unknown origin.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-4839e0bdbe294d478ac25b9a52cdc89b",
            "input": "Comparing baseline CGI with that obtained on the date of last evaluation for each patient, a significant improvement in clinical assessment of severity of illness was obtained for the total group (Wilcoxon signed rank test, p < 0.0001).",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-094ed8397ebb462d8e6641f9af9c9c29",
            "input": "The presented case illustrates that a combined overdose of tricyclic antidepressants and neuroleptics enhances the possible toxic effects of each drug and especially the risk for adverse cardiac events.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-28ecac4f49834f219761ccf7e04934b0",
            "input": "On day 15 of cycle 1, he reported progressive worsening of weakness and fatigue, and melena.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e9a9eff933014971ba24a002904bde3f",
            "input": "CONCLUSION: This case provides support for the practice of obtaining routine fungal cultures of donor rims at the time of corneal transplantation and for the implementation of prophylactic antifungal therapy in culture-positive cases.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ed8610aaa4b54b8cb028fba27ca82862",
            "input": "Despite treatment in the intensive care unit, the woman died on the sixth day after admission.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5ce0432173ba4333a662bba69bd5e688",
            "input": "This case is the first report in which RLS augmentation is shown to be characterized by motor hyperkinesias paralleling levodopa plasma pharmacokinetic profile.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-85e416fd472d402ba908ed11e807ec5e",
            "input": "Miconazole a new antifungal agent was used with dramatic response.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-45565bad0f0b406aa037c643ddf65d15",
            "input": "Management of upper gastrointestinal haemorrhage complicating dual anti-platelet therapy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5c4f5ca098ca441bb1b38fd308584d0f",
            "input": "The acyclovir levels measured by radioimmunoassay were related to the level of consciousness.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-4b1e8621bcc74032a7211504be666980",
            "input": "Clinical and electrodiagnostic findings are discussed in detail and a brief review of the literature is presented.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-56fdac17a53a488786480bc0b11a49ce",
            "input": "Discontinuation of etanercept led to control of heart function.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-0f328a43e7284e8db62080d7d9395dc0",
            "input": "The only recent change in their treatment was the introduction or increased dosage of zonisamide.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-087539dc29b1437e898bfc68708c47cb",
            "input": "RESULTS: [1] Mucin secretion was increased by 63% over the controls in the VVR in vitro group (p < 0.01).",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-01e10c5004544e6384215317983740ac",
            "input": "Histological examination of a skin biopsy was consistent with leucocytoclastic vasculitis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-4267c37dd6964d32a138bfaaea5ac076",
            "input": "Acute spontaneous TLS is rare, and it has been described in leukemia and lymphoma and in some patients with solid tumors prior to institution of therapy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-0e09c1134d9048a2aacffe8719fdce21",
            "input": "Significant deteriorations were demonstrated in cognitive (p = 0.04) and social functions (p = 0.04), compared with assessment of pre-morbid function.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ebf0ef3b7d9a4c3f86a83ff88258bbbd",
            "input": "Clinicians should, therefore, consider AI in patients with spinal cord injury receiving glucocorticoids, a population in whom it may otherwise go undiagnosed and untreated.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-2ee84938046641a5b3e0c022fd245dd3",
            "input": "About three weeks into the therapy regimen, he complained of severe retrosternal chest oppression.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5c02ce72107b4bc7bac6a9fae7be560a",
            "input": "The patient received OLT because of end-stage primary biliary cirrhosis and was found to have de novo HBV infection 3 months later.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-27fca847d3a34fe989724e8e3f32dbc7",
            "input": "We conclude that symptoms of a postdural puncture headache can mimic those of postpartum preeclampsia.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-4b56d1004d1a4fc285e850778bd394f6",
            "input": "A multicentric retrospective pilot study was undertaken to detect GCV-resistance through mutations within the UL97 gene in renal transplant recipients who experienced active HCMV infection and received valacyclovir prophylaxis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-4b271cb3e0e6443799bd3da7f6111edb",
            "input": "We describe an infant who developed juvenile glaucoma with buphthalmos while receiving systemic steroid treatment.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-60972250513a478d89b57adbd550d98c",
            "input": "Clinical resolution was achieved with granulocyte colony-stimulating factor and amphotericin B administration.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-30115fe2d6944f6cbc281aef73b47874",
            "input": "Their criticisms also differed from a third criticism contained in the article as well as the protocol being advocated in the article, thus contravening the claim that there is one prescribed protocol which must be followed.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-78269ac348dd4f1b8c43521a532cd79e",
            "input": "PURPOSE: We report a case of a patient who developed a postoperative anterior spinal artery syndrome that was masked by the use of epidural analgesia.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-aadbd23e6f894abbab6b4354d4afea55",
            "input": "G-banding analyses of bone marrow cells had repeatedly demonstrated normal male karyotype before this event, but t(9;22)(q34;q11) was demonstrated after the event.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-b7058d39acf445bb893cef215f2b7321",
            "input": "Short cardiopulmonary resuscitation restored spontaneous circulation and the patient recovered completely.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-cbe841b26365446589d98d37c162806b",
            "input": "The use of methylphenidate and imipramine in Gilles de la Tourette's disease in children.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8e720e9bf81b42dca5b083e6db46dfaf",
            "input": "During a second FAB infusion (400 mg) the patient reverted to regular AV-conduction.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ba3ae1bff14145a68b38f8e5ecc25bd7",
            "input": "Diffuse pulmonary infiltrates in immunocompromised patients.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c5de7ea11eee42c3bfd7025cc4bdd51d",
            "input": "Pentavalent antimonial drugs used for the treatment of leishmaniasis have been associated with sudden deaths, probably due to the development of ventricular tachyarrhythmias.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-14a52294dd3642c9838723bb328beaf1",
            "input": "Apart from some minor discomfort at the site of operation, no side effects were noted.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-826b0c72340a486a8f38fda6413e419b",
            "input": "The patient developed tonic-clonic seizures, which resolved with diazepam and midazolam therapy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-2b073dfb4b3c4c61ad0b4c472cea7e64",
            "input": "The treatment was continued for 6 months without recurrence of the symptoms.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-330d897b8f7f4215b53abb97efa61083",
            "input": "Thrombolytic therapy is being used with increasing frequency to treat acute myocardial infarction (MI).",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-17c9a9715c4a404a9be3d0028921e5d3",
            "input": "This review provides an evidence and experience-based approach to the preventive treatment of migraine.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-b556f8d62ce442bdad64a8b44f569b5f",
            "input": "That feature underscores the heterogeneity of the FAD clinical phenotype.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-10a229748d084a968aa38ca3f3c223d4",
            "input": "Persistent corneal erosion secondary to tarsal adrenochrome deposit.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-7232cbb272bd4ff6b24d0b441c58a42f",
            "input": "This is a rare complication of bypass surgery and may be a cause of recurrent angina postoperatively due to coronary artery steal.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-0bbfad80992f421eb3fcebf433692677",
            "input": "Combination of sodium thiosulphate, cinacalcet, and paricalcitol in the treatment of calciphylaxis with hyperparathyroidism.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-f89dc1c34b024c2abe8e7017eec7b990",
            "input": "Cytomegalovirus is a common infection worldwide and in the immunocompromised individual it can be a major cause of morbidity and mortality.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-fa58d5451ddb4b13bb94081a33534cca",
            "input": "Spontaneous regression of the lesions was noted after discontinuation of the treatment.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c5627fdfb162441fa0680f4139de190e",
            "input": "This avoids the need for bronchoscopic examination or transfer of the patient for computed tomography.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-7d617c73b11e440c8f7a6bc08b046cea",
            "input": "The decedent was also prescribed tramadol, gabapentin, cetirizine, modafinil, carisoprodol, and Xyrem.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-6280393d96de4aa680d911830b066caf",
            "input": "Thus, further therapy must not be withheld.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-aeaa7451ca0448f6a77bb1c3596be9a3",
            "input": "Wolff Parkinson White (WPW) syndrome: what the critical care nurse needs to consider when administering antiarrhythmics.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-936b4e6bc82548d9a3fff0309565bf2e",
            "input": "The erythroid defect fully reversed after the drug was discontinued and could not be attributed to the patient's previously treated lung carcinoma.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-0d17957004914c80981889f03b585260",
            "input": "Niemann-Pick type C is an autosomal-recessive, neurovisceral storage disorder that results from defective cholesterol esterification.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-1172c5e0f43d4a9c99414ccc90c82318",
            "input": "Prosthetic joint infection is an infrequent but serious complication of total joint arthroplasty.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-f476261469864010a076c7ea10804740",
            "input": "The possible role of AK inhibition in these clinical responses requires further investigation.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c1e6e1d6813e4126924b3c9de06d1ab7",
            "input": "Central nervous system imaging was negative.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8a73341ecf55419aa872ce821eed4322",
            "input": "Control hysterosalpingograms showed no tubal patency on the involved side.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-fd4fef347f284cbc9c7ae9b27001750a",
            "input": "The severity of the haemorrhagic diathesis prompted us to describe the case in order to draw the attention of medical personnel to the dangerous potentiation effects of different drugs administered with vitamin K antagonists.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a2c70df4b91b4de4ab1347c2b902cec4",
            "input": "CONCLUSION: If a parotid duct injury is diagnosed at the time of tumor extirpation, then surgical repair of the duct should be attempted, but if surgical repair is not possible or if an injury remains unrecognized until well after tumor extirpation, then surgery is not necessary.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ff06dfde04af4a86bab6505cd3043863",
            "input": "S-1 is an oral 5-fluorouracil (5-FU) anticancer agent and has shown promising effects in the treatment of a wide range of carcinomas, including head and neck cancer.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a940c459eb274ab5b42bba74ec773aba",
            "input": "The diagnosis of C. difficile was confirmed by a stool-cytotoxin test and endoscopic examination.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c10293b06c664684abb39815c6c256a2",
            "input": "DISCUSSION: SIADH has been reported as a complication of treatment with vinca alkaloids.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e4ca513ad508456084f14b0481e7e303",
            "input": "Peritonsillar bupivacaine infiltration, a relatively safe method of pain control, is in some centers frequently used by otolaryngologists for pain relief.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-23b2dd709d13486589ca53f50cc80983",
            "input": "The patient was initially treated for presumed bacterial peritonitis but remained febrile and had persistent abdominal pain and peritoneal fluid pleocytosis, despite broad-spectrum antibiotic therapy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-88bb2ed149a64545a30eb9f09aa26d28",
            "input": "This report emphasizes the unnecessary hazard accompanying use of a potentially toxic drug-especially when prepared in error by the pharmacist-when a safer drug (nystatin) is available for treatment of oral candidiasis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c56af063146548d2aef603a08138badf",
            "input": "DISCUSSION: According to the literature, reversible nonthrombocytopenic palpable purpura has not been previously reported with metoclopramide.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-37f3a15c231241e7870783b3bfde0cd6",
            "input": "RESULTS: In one patient the rifampin-impregnated shunt system was implanted after external drainage to prevent further infection.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-b9129d5dd64546f0b8a55bb4cfcaecb3",
            "input": "Free SDCs were obtained using an ultrafiltration and fluorescence polarization immunoassay system in three patients over periods of up to 204 hours after Fab administration.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e04900fbb3634920a8a418c9b95ff35f",
            "input": "Photopatch tests to 1% mequitazine with 5 J/cm2 of UVA in 30 normal subjects were all negative, which means that 1% concentration may be appropriate for the photopatch test.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-9fe24085eb034418bd778a54bf7dfd06",
            "input": "As with any new therapy, we suggest waiting for the results of a randomized, controlled trial before recommending this treatment.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-06fc497b82fa49f6ab434f7a9eede531",
            "input": "Acromegaly increases the overall risk of neoplasms.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-aaf266e12fad4c3fbb59910cd70ddca1",
            "input": "Pathophysiologic concerns have also been a key reason why physicians have avoided using beta-blockers in patients with diabetes.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-462ab7d327f44651872bed855dfe2f16",
            "input": "METHODS: Case report.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-4b022186caf341e8bf48d127deb83d8f",
            "input": "All 3 patients experienced fairly typical chest pain syndromes and experienced elevations of cardiac enzymes consistent with myocardial ischemia.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-feef5b89c86040b1892bfb3849c5bc1b",
            "input": "CONCLUSION: We conclude that stanozolol is a safe and effective treatment of the cutaneous manifestations of cryofibrinogenemia.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-fb9a45d389764cd785f263c0ac331bf0",
            "input": "We suggest the use of trihexyphenidyl in combination with isoprinosine in patients with subacute sclerosing panencephalitis with myoclonic seizures refractory to valproic acid.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-10976bc80e26489ba23b3710660cb221",
            "input": "A case of necrotizing fasciitis of the vulva arising in a leukemic patient during a chemotherapy nadir is presented.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-43cb912d8b57429788407e2152f37d03",
            "input": "In patients who show abnormal liver function tests, the immediate discontinuation of gliclazide is recommended.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ed288ab093984c2f8a666b9b64c10f45",
            "input": "To put this into perspective, total aplasia of red blood cells for 40 days would result in a drop of 30-33% in the red blood cell count.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3ea36bd3c1e34943b3d4349ebe609bd1",
            "input": "The recognition, differential diagnosis, and management of this syndrome in children are discussed.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-1110e3367e8a47fe835dd4eacd0aad6b",
            "input": "In rare patients, systemic absorption of inhaled tobramycin may be significant enough to produce toxic effects, such as renal and vestibular toxicities.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-7f7ecd16e4174bf5801ce87630f87f6c",
            "input": "BACKGROUND: Tumor lysis syndrome (TLS) is rare in the treatment of solid tumors, but it may occur in myelolymphoproliferative diseases.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c5d44387365e4610b956c9d7ba5b736f",
            "input": "The patient was not obese.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-7f8eecab1577401289a86518ed496edb",
            "input": "PURPOSE: To report a new adverse effect related to treatment with bimatoprost.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-612480c07843431a828baf4d65cc2c5b",
            "input": "As a result, we identified total 11 patients with nocturia and three of those completed the 12-week study of switching dopamine agonist from bromocriptine to pergolide.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a6075da7413d49da982b39241a686234",
            "input": "Toxic streptococcal syndrome is characterized by fever, shock, multiorgan system failure and a desquamating scarlatiniform rash.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-1cc8e6b387c84e6ab46d5afb0e7d3c35",
            "input": "The administration of amyl nitrite and sodium thiosulfate led to a rapid improvement: the parameters reflecting oxygen metabolism improved and the plasma level of cyanide decreased.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5c149557472c466b8df7cc1114da6122",
            "input": "The combination of levodopa and peripheral dopadecarboxylase inhibitor is the most efficacious symptomatic treatment for Parkinson's disease.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-898c54a6cf6c445586ff3d5539b05267",
            "input": "The response of the occlusion of nearly all liver venules underlines the value of anti-inflammatory treatment combined with new thrombolytic medication such as defibrotide for the treatment of severe VOD.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-88a2ca25414949a7a37f4399f91ab75f",
            "input": "The reversible posterior leukoencephalopathy syndrome (RPLES) is a condition characterised by reversible neurological and radiological findings that has been associated with use of immunosuppressive, chemotherapeutic and more recently novel targeted therapies.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-30dd5d482fae49fa987d955cb605d1af",
            "input": "In our experience, the correct diagnosis and effective treatment at an early stage proved to be helpful to the patients in pulling out from the critical stage of acute radiation sickness.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3fef2ad22f2d44d88efb8714e9b7c1a7",
            "input": "Both reactions occurred late in the course of treatment.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ddde49de2238401894b09d664b13f669",
            "input": "A 600-mg loading dose appears to shorten the time to achieve an adequate antiplatelet effect to about two hours.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-dc36c68a7e4342d8a8ed0e60d0688964",
            "input": "Disease behaviour in two patients was classified as penetrating because of concomitant ischiorectal abscesses, while one patient developed a metastatic colon carcinoma.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-50873c7702454795909438d01bcc49b0",
            "input": "Bilateral computerized tomography showed no progression in radiographic changes during the treatment.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-6faea14b38664c43a644f6925129a421",
            "input": "Spironolactone was continued, as serum creatinine and potassium levels were initially normal.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-69ebec6326d443d39de1ea3b7e402274",
            "input": "Clindamycin for treatment of Toxoplasma polymyositis in a dog.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-7040dd129d884a4e943be516fed30ce4",
            "input": "A case of recurrent impetigo herpetiformis with a positive family history.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-4e112a96c77b45939c54c0264113914f",
            "input": "We present foreign body granulomas induced by activated charcoal from intraperitoneal chemotherapy and mimicked peritoneal metastases in the patients with gastric cancer.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-fbc54f7d7ce14584a98527f0cd6b2283",
            "input": "Seven patients only smoked at night-time (median dose eight puffs, range two to eight puffs), and eight patients used cannabis mainly during the day (median dose three puffs, range two to eight puffs); the median frequency of use was four times per day (range one to 16 times per day).",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-16a79190bea0476a8a9ae7146fe2fb0d",
            "input": "METHODS: We describe the case of a 41-year-old male with HIV who received protease inhibitor medication and had neurologic deficits rapidly develop.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-9c41a8fe45ac42689d594824f94d8b8d",
            "input": "Radiological imaging revealed diffuse cortical necrosis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-9237ed894f4c432db8b0d76746cf60e8",
            "input": "Acute liver dysfunction complicated with uncontrollable glycemia due to insulin antibody: successful treatment with glucocorticoid and lispro insulin.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3a7faab3f2834bbfac232c2e6e0c980f",
            "input": "Antidepressants and myoclonus: case report.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-664b745136c6403a8e56cebaacf8cdb6",
            "input": "Calciphylaxis (calcific uremic arteriolopathy) is a severe complication of hemodialysis characterized by subcutaneous calcification of the small arteries and tissue necrosis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3d950313cb9f48449e548722e84dd812",
            "input": "Two ajmaline tests were both negative and ruled out the diagnosis of BS.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-b7df6e280b334adc920a31a7d3260cfa",
            "input": "We studied 13 healthy volunteer subjects, performing three hepatobiliary scans in each one.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-db2da8ead81d44d1823c0530c3d45c0a",
            "input": "To avoid that toxicity, a new weekly schedule has been adopted in several Phase II studies.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-1656e27a35e941778d4804c67d231d7b",
            "input": "Cyproheptadine for intrathecal baclofen withdrawal.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-2e44a69f8d994ae9957f470ab3e89bd3",
            "input": "The anti-epileptic agent trimethadione was given orally to 30 outpatients at a dose of 0.9-1.5 g daily.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-be12dd5e49c94a6ca4c577b71b0d3f76",
            "input": "Triptans are specific agonists of the serotonergic 5-HT(1B/1D) receptors that have increasingly been used in the treatment of migraine and cluster headaches.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-05ef831835244ddba649f30bd75db2b5",
            "input": "In addition to the therapeutic benefits, prospective monitoring of free SDC in two of the patients also may have resulted in cost savings secondary to reduced hospital stay or less use of Fab.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d1203311a5b345b5a56892890ce797ba",
            "input": "We here report the first case of psoriatic arthritis which developed lung cancer.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d6097162afba404e95f6ca28939fe912",
            "input": "Dermatomyositis, complicated with pneumomediastinum, successfully treated with cyclosporine A: a case report and review of literature.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-17d8074717704216be9eebbfd21f9a0a",
            "input": "Chylous ascites, a rare compliation following retroperitoneal lymph node dissection, has not been reported as a means of spread of testicular cancer.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-2c5038afc31245328157c8ad845e6144",
            "input": "Abdominal ultrasound was normal with the exception of a slight hepatomegaly without any lesions, focal or diffuse.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-bc5139d0ffe7494b82f320fbb93c636a",
            "input": "A manual pumping test is commonly used to verify the patency of a ventriculoperitoneal (V-P) shunt.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-f0750dae2f7f40519a8d68ed4b764924",
            "input": "CONCLUSION: Our case shows a fatal side effect of erlotinib.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-737a7b594d23460cabd8e9a43a6ac826",
            "input": "The advantages and disadvantages of uncontrolled case reports are reviewed using two cases of false-positive reactions to drugs as illustrative examples.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-79dbe30a990f4d14803f38a128c08726",
            "input": "We review and summarize all reported cases of patients with ART-associated lactic acidosis reported in the English literature.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-588e9b42546f43c7ba43c749cd41c80a",
            "input": "The ability of clozapine to suppress tardive dyskinesia symptoms raises the possibility that clozapine, at least at the doses used in this report, might also induce the disorder.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ef02443d159f4d77bb1a4d19e7b4fc71",
            "input": "Taken together with other evidence that fluoroquinolones lower seizure threshold, this report suggests fluoroquinolones should be avoided in patients receiving ECT.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8d27cb034cb8443c812e91dfb964cbdd",
            "input": "Acutely, SMS decreased acid secretion and restored the BAO/MAO to normal in eight of eight patients.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-4d85f274579446d28a5f4c1394249627",
            "input": "The exceeding of the solubility product of Ca(2+) and PO(4) (-) results in the precipitation of calcium phosphates.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-57459345ed3d484db281ce5ed6eb5c63",
            "input": "After an interval of 3 months, he presented a complex pattern of nail hyperpigmentation, from combined dense horizontal and longitudinal streaks in some nails to diffuse black discoloration in others (Figure).",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-9511d786bfa648d99f779f4c782a8c0f",
            "input": "Treatment of antithyroid drug-induced agranulocytosis by granulocyte colony-stimulating factor: a case of primum non nocere.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-86803cd031c14059a44db26a542f1aa4",
            "input": "Brain abscess following insertion of skull traction.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8b54be94725e4827b3d0ff0cf3e1cbf9",
            "input": "One 13-year-old boy with life-threatening systemic disease experienced a partial remission of disease and tolerated a decrease in prednisone dose from 15 to 4 mg daily following 14 exchanges with FFP.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-bf40045a222d452688779ff0345b0448",
            "input": "Adalimumab in the management of palmoplantar psoriasis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-acf1b88ea82b44e69cc517b1390457d4",
            "input": "It must be considered as a potential source of cerebral hemorrhage in elderly patients undergoing thrombolysis for cardiac ischemia.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-fc55f2f8f3a7417d835573dbbc5f3592",
            "input": "In the second patient, acute renal failure necessitated hemodialysis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-6bf1aefcb46149548912b580fcdc70a5",
            "input": "Patients should be informed of the risk of septic arthritis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d7c633f267324fe8b2e3da797b7f26e1",
            "input": "The case also highlights the increased cardiovascular morbidity in testicular cancer survivors and evokes the possibility of mechanisms of myocardial ischemia other than atherosclerotic disease in these young patients.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-899a09cc219b43af81d8af12d2fb0550",
            "input": "However, the patient later succumbed to her leukaemia.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-2b74d7c31f9347e3bfe3a70d914246cf",
            "input": "A 10-year-old boy was diagnosed with ADHD and had received methylphenidate hydrochloride, 60 mg/day for 2 years.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c779304ba5a24b8b8d28e5f273215079",
            "input": "Hydroxyzine alone caused an insignificant delay.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-153f773161cf41dd8b485a0d48af2843",
            "input": "The potential for absorption is not well described in patients with impaired gastrointestinal (GI) mucosa.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-18aa3a8044bd46b3accc1a4909ffe647",
            "input": "She developed a febrile illness associated with severe pancytopenia and leukocytoclastic vasculitic rash followed by diffuse adenopathy, with serologic and pathologic evidence of EBV infection.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-b6399c6141dc43b8a13ab566aeeee521",
            "input": "PCR analysis showed CMV-DNA in the failed graft.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-439626286cb1432f8abd000e54ae1c2a",
            "input": "The conditions treated were: Hodgkin's disease (four patients), primary amyloidosis, primary macroglobulinemia, malignant lymphoma, multiple myeloma, and carcinoma of the tonsil.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5fcaf935e3414486be5320fef14be495",
            "input": "Two had positive antihistone antibodies.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c1a8afbd30e74f0d82a4601435509eeb",
            "input": "Concurrent use of reteplase and lepirudin in the treatment of acute anterior wall myocardial infarction.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-1c856eeeedd34ecfac0af2b7ce2c8bed",
            "input": "This deterioration started 3 months post-treatment and worsened over the ensuing 4 years.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-6abd5547162f4cdb981d613e37d29b33",
            "input": "For 9 years the patient remained totally asymptomatic.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-71e7b02e8fb846eaa18f289a8ddff4ad",
            "input": "RESULTS: The mean age and duration of illness of the patients were 38.93+/-8.36 and 12.88+/-6.90 years, respectively.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3ff5d157b5d8444fa2576d244af8dcc9",
            "input": "We report on a patient who underwent renal transplantation using Campath-1H induction and tacrolimus maintenance therapy who developed HUS, which was managed by plasma exchange and switch to Rapamycin.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e5fae8be167c4d6896d2ba3056a20e4a",
            "input": "Documentation of adverse events for safe and commonly used drugs is important.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-950bf9791edb4fcc82ea41457b53d120",
            "input": "After prolonged recovery periods, only mild neurological deficits persisted in both patients.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8a991e14e3884dde80006f186374ba5b",
            "input": "Systemic cytomegalovirus infection complicating ulcerative colitis: a case report and review of the literature.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-14ffd06c7cf740b0a2b1c1f225af8129",
            "input": "The patient was regularly taking a mixture of herbal products, used as a laxative, for a number of years, with no alteration of blood chemistry until 6 months before the present observation.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3662a445aee84ad78f120ba0c1b4fc13",
            "input": "BACKGROUND: Recombinant activated factor VII (rFVIIa), originally developed for the treatment of life-threatening bleeding in hemophilic patients with inhibitors to factors VIII or IX, has been increasingly used to control hemorrhage unresponsive to conventional treatment, in the absence of a defined coagulopathy or thrombocytopathy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-adecad340ecb4c30a609c1ac5cbff326",
            "input": "MATERIALS AND METHODS: Two dialysis patients with recently rejected renal allografts who were hospitalized because of fever of unknown origin are reported.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-62dedbef8cb14180ae9fe0bd8f7b6a78",
            "input": "Ultrastructurally the follicular cells contained large residual bodies composed of abundant electron-lucent lipid droplets of variable size.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d180885b6d0140b9a3b2b85accac9fff",
            "input": "After unsuccessful fluid resuscitation with crystalloid fluid, the patient's condition improved rapidly with human albumin boluses.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e9a5153b1e9046c2a7dac893f0305a42",
            "input": "Treatment of hepatocellular carcinoma using arterial chemoembolization with degradable starch microspheres and continuous arterial infusion of 5-fluorouracil.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-63e5143a820c4abb895eb0a2904af40c",
            "input": "Nosocomial malaria and saline flush.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-65a9bc52ab354660a15150c970e07514",
            "input": "Dopamine agonists are increasingly used in the treatment of Parkinson disease, but they may cause serious adverse effects.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-9acd4a2dabe6494bb3071aa184051f3a",
            "input": "Before starting Zoledronic acid therapy, the patient's serum calcium level was 6.9 mg/dl.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-63689c4b2e5c4d96ab926e169e7728ba",
            "input": "A case is presented in which amiodarone was administered to suppress paroxysmal atrial fibrillation in a patient with an idiopathic cardiomyopathy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-6b994699c41946acae90dade315a99c0",
            "input": "PDT was performed twice, but after the second cycle, patient developed choroidal ischemia and the visual outcomes were poor.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-dc61b1aaf3fc49d99f39f432a4596d73",
            "input": "The second is a case of superficial invasion of Candida in a stitch ulcer.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ac35aef1fdef4f8482eeba12a59f0246",
            "input": "Subsequently, the patient presented with a lower eyelid mass, which on excision was demonstrated to be a chalazion.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-7abb423461114036b4d0745121d908e5",
            "input": "The mortality rate has been estimated at about 10%.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-76fc798d1671409ca98cfb41e3146b0d",
            "input": "A 33-year-old man with advanced testicular cancer underwent high-dose chemotherapy combined with peripheral blood stem cell transplantation.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-1f2639f7223740d8abb83ccff0d6879c",
            "input": "The mechanism of the interaction is probably inhibition of glipizide metabolism rather than protein-binding displacement.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-24731366f37848588bca6d9d1a307f49",
            "input": "Sometimes the presentation is with diabetic ketoacidosis, requiring insulin treatment, which can nevertheless be reversible.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-cfa43d2b719c4a74ae92332e8940e6af",
            "input": "All patients except two had new recurrences within the observation time.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-6cecce172b0d4151a7518352d0e46626",
            "input": "Many new serotonergic antidepressants have been introduced over the past decade.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-6153eb78449e499b82c040efb23fdb50",
            "input": "The response to chemotherapy was not satisfactory.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-7bc8f7c5b8c04491bd45507ee41f125f",
            "input": "Liver biopsy disclosed submassive hepatic necrosis.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d2487984695f40b9b085d04a79d8118b",
            "input": "RESULTS: Complete thrombosis of the mycotic aneurysms was achieved in all patients.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-14dd115f97cc4b3eb96bab1bf6721134",
            "input": "The reactive process included an infiltrative superficial dermatitis and a mural folliculitis with prevalent participation of macrophages and lymphocytes.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-29acad1d9b04441abc188ac8bb7206e7",
            "input": "Photochemotherapy using psoralen and ultraviolet (UV)A irradiation (PUVA) is a useful treatment method for vitiligo.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ce4f8da9cd884a23b4144c75ebcaec9c",
            "input": "This case and the brief review of the literature which follows emphasize the danger of prednisone administration in patients who have asthma and a history of drug intolerance.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-2e469a3f4c9f46f5b4e5b99199b22c1d",
            "input": "Two cases, one of leukemia and one of a trophoblastic testicular teratoma, are described in which hypoglycemia occurred as a terminal event.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-afd5ab062fa242c5a611abaa27548f46",
            "input": "Autopsy demonstrated extensive necrosis of the tumor mass, as well as necrotizing vascular damage within the neoplasm.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-12a48d3958fc4b2d9745ca46dd0fc60d",
            "input": "Clinical and chemical improvement was observed in the majority of subjects but normal 24-hour serum growth hormone levels were achieved in no more than 35 percent of this group and possibly less.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5dee17b1223845028c126e596661aa10",
            "input": "Cessation of MTX therapy led to complete regression of the tumor.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-76250793abdd470196d627e040afc3d4",
            "input": "DESIGN: Description of the clinical findings in two patients with this condition.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-bcbeee416aa740a486fcbf404cddd471",
            "input": "Drug-induced ocular pemphigoid has been reported to occur after long-term use of topical glaucoma medications.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-b6640c6929584719987cd26706234118",
            "input": "Further study revealed that all three patients had low plasma renin activity and nonsuppresible plasma aldosterone levels after saline infusion.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8b779e36988141e4ad540f289845a341",
            "input": "METHODS: Tissue obtained during vitrectomy was cultured and examined by light and electron microscopy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-46c54e44bbd6449b947d4f1aa38ae216",
            "input": "Side effects associated with this medication are usually minor; serious complications are most often due to the delivery system required for continuous infusion.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8a549e2bbef94b66bc32e9c15b2e8c8f",
            "input": "Cutaneous biopsy showed hyphae and round inclusions stained with PAS and Gomori-Grocott within a polymorphous granuloma.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-7bc6ce7317ea4d5aaf03fcec6febe18b",
            "input": "After previously tolerating ECT well, introduction of moxifloxacin for a respiratory tract infection was associated with prolonged seizure duration despite complete resolution of her respiratory complaint.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-48dfd9ec65b140edb7d960bd07a92fd4",
            "input": "Continuing the treatment with 13-cis-retinoic acid without systemic steroid eventually cleared the systemic manifestations and skin lesions.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-17481b91746c412dae5b2d3d27550b88",
            "input": "One patient died suddenly during an exchange with FFP; the cause of death appeared related to microemboli of unknown nature found in the lungs at autopsy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-30954d5833174a0ea6f72b70203ea153",
            "input": "Iron was absent.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-2472b46347bf472db94e05f51ed588c0",
            "input": "Adrenal suppression and failure to thrive after steroid injections for periocular hemangioma.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5418b985cd9b42df83a442ad0580b0df",
            "input": "Traditional neuroleptics have been the mainstay of treatment for agitated behavior in persons with dementia, but these agents have limited efficacy and are associated with high rates of adverse effects, including worsening of already poor cognitive functioning.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-b42bdb71f21b4cc7b04708d814684054",
            "input": "Four cases involving men with New York Heart Association functional class III heart failure are presented.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-01c4c2a13e564067ac68f486b737950a",
            "input": "CONCLUSIONS: Complications concerning a primary perforation of the bladder and instillation of chemotherapeutic drugs can be easily avoided by recognising the perforation intraoperatively.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a9c67dfa31c24ad5af561a33046c67e0",
            "input": "A neuroprotective and neuroregenerative treatment attempt with pyridoxine and pyridostigmine was initiated.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5882c10cd94741539cfdea541bb27127",
            "input": "Care providers who refill pump reservoirs with morphine must be knowledgeable about these devices and the life-threatening consequences associated with errors in refilling them.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-366a1da6f48349299ad4177dd3fe49c1",
            "input": "After a latent period of 4 months, he developed a progressive, severe and ultimately fatal radiation myelopathy, which we suggest was due to a synergistic interaction between the high-dose chemotherapy and the radiotherapy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-b0c830121a0345389d2484e8255d6f1f",
            "input": "Recommendations that may help prevent these adverse systemic effects in premature infants include: (1) avoidance of excess subconjunctival anesthetic doses, (2) preoperative administration of systemic atropine to minimize the oculocardiac reflex, (3) consideration of an analgesic agent to decrease the pain and exhaustion, and (4) cardiorespiratory monitoring in a hospital setting, with an intravenous line in place, at the time of treatment.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5856c38dafd644e48ea26d1b7d92de60",
            "input": "The concentration of pseudoephedrine in blood and liver specimens was measured using gas chromatography-mass spectrometry and was determined to be 14.4 mg/L in the blood and 16 mg/kg in the liver.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-695b87b187df496aa2756c6318a22456",
            "input": "Scapular upward rotation is predominantly achieved via a force coupling involving the upper and lower trapezius and the serratus anterior.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-bef097c72e0f4722af83cf631364bc8e",
            "input": "Some cases run a chronic severe course and fail to respond to local and systemic therapy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-4f97d191e0f04d3f84be422de6b3fadc",
            "input": "KS is a rare complication in glomerular diseases that may (or may not) be related to immunosuppression.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d29c1c0d915745428260feb2205070e5",
            "input": "Although HCV-RNA reappeared in the serum at 3 months, the patient had continued ALT normalization and histological improvement with follow-up of over 26 months to date after the initiation of the combination therapy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-62756b3498ef4a9b98398dec6d78d577",
            "input": "Flavimonas oryzihabitans (CDC group Ve-2) bacteraemia associated with Hickman catheters.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d25bbeb902bc40a1ab5de2a5c375e2fa",
            "input": "CONCLUSIONS: The results of our study suggest that the pharmacokinetics of parent ifosfamide may not be substantially altered in patients with renal failure.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-50e2e38ad0d7401e884cfbf074e56ffa",
            "input": "A stage Va B-cell multicentric lymphoma was diagnosed on clinical, cytological (lymph node, bone marrow), histological-immunohistochemical (lymph node excision) and imaging grounds.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-9507e6914ce341eab1633c5e92cd11ba",
            "input": "Infected graft transplantation is an unwelcome complication that may lead to serious consequences in the immunosuppressed host.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-ed63c28232b54d7c8402afe8970d0cab",
            "input": "A case of hepatocellular carcinoma in a young female is presented in which the apparent etiology was the use of oral contraceptives for 5 1/2 years.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d45d8010cd28450f9cb44f31241df8da",
            "input": "Three patients with T315I abl-mutated chronic myeloid leukemia (CML) or Philadelphia chromosome (Ph)-positive acute lymphocytic leukemia (ALL) have achieved clinical responses to doses of MK-04547 that are not associated with adverse events.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-55316469b28a484bab81fe5f25b32218",
            "input": "Progressive multifocal leukoencephalopathy after stem cell transplantation, unsuccessfully treated with cidofovir.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-79c83e0bee4748a891abe06287d720a8",
            "input": "Ten months after the injection, visual acuity remained at 20/50, and intraocular pressure measured 15 mm Hg without antiglaucomatous therapy taken.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-39c73b39cb834e6494cda6de3c450f46",
            "input": "His obstruction resolved, and he remains well at 11 months.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-f4e59e4d94d847a08e3ab0d5a5703f25",
            "input": "As NBD-Cl has not been reported as an allergen before, the characteristics of this chemical and its use as an analytical reagent are briefly surveyed.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-b563f7e659a3467b9e7b3616c74132cc",
            "input": "In one case the growth rate and cortisol response returned to normal 9 months after the fluticasone dose was reduced to 500 micrograms/day.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-2c74923eeb3c44bb8c675f61f3d09e88",
            "input": "In two patients, adenosine precipitated acceleration of ventricular response, in one case necessitating emergent cardioversion.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e03563221a914fc49994edd629e376e1",
            "input": "His symptoms included bradycardia, hypotension, hypothermia, pallor, cyanosis, and impaired consciousness.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-f8946db921644268a84bd0a314478e3f",
            "input": "In one 12-month period he had 88 separate admissions to an emergency department with severe hypoglycaemic coma requiring intravenous glucose administration.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8dd425e650a744b981632048822f4343",
            "input": "Two of these cases concerned relatively young, previously healthy patients and had fatal outcomes.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e387a8b5b0b7441d965b2cbdfc68369d",
            "input": "Three cases are described in which periorbital topical corticosteroids appear to have resulted in raised intraocular pressure or glaucoma.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-7fc4bb893d0a43da9c337a6f9edcd4e0",
            "input": "Four of the aviators were allowed to continue on active duty with limitations and one was disqualified.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-afa7c62c46654db98b735e21984333a7",
            "input": "In this article, four patient reports of a specific interaction--the serotonin syndrome--are presented.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-10437fff6c7c4c7ebbc7f36036d49a41",
            "input": "Results of coronary investigations were negative.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-135d7ffca4524a30be2a0548d6a686d6",
            "input": "The pertinent literature on ergotism is reviewed, and it is emphasized that ergotism may develop in patients on therapeutic doses of the drug.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-3ec3d729c16743cd97217ba811684812",
            "input": "History revealed that the patient had taken a combination phenolphthalein/docusate sodium (Correctol) over-the-counter laxative 1 day prior to admission.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-92d2731957a749eaa13dfb4050c80532",
            "input": "Hemoglobin electrophoresis and methemoglobin reductase determinations were normal for age.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-4740daa6ee4f4e03a66166e5c6be2d1a",
            "input": "The regimen was based on conditioning experiments with animals who had lupuslike autoimmune disease.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c677cca892c4426f8b72140e057b2423",
            "input": "Conspicuous endoscopic appearance of ventriculitis caused by coagulase-negative staphylococci.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-57688bbbf0ff40e990cb669a231dcacc",
            "input": "High doses of atropine (up to 50 mg per 24 hours), adrenaline and dopamine were necessary.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-957374c244e943d99034f87a773f0185",
            "input": "Anticoagulant therapy was initiated with subcutaneous enoxaparin and oral warfarin.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-1a757ed85fda4ab9955507d2a8c4adf0",
            "input": "Overnight sleep studies and multiple sleep latency testing were carried out under double-blind administration of either L-dopa or placebo.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-8bc06f1f548f4457a5b02a6e5fe98ec5",
            "input": "This was initially diagnosed as a spreading dental infection.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-e0a8af835a424be78f9da380c41306db",
            "input": "The patient subsequently responded well to intravenous antibiotics, intravenous corticosteroids, and local wound care.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-460de50d09ef45049dbad4c457c74ce0",
            "input": "To the authors' knowledge, this is the first report in the English-language literature of spontaneous neonatal intracerebral hemorrhage, due to thrombosis of the superior or inferior vena cava.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-6016a49cc7704d6cab443d84354f8395",
            "input": "Evaluation revealed CMV viremia with a high viral load and CMV gastritis was confirmed using gastroscopy and histopathologic examination.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-2c7cd24aa5754bb5bbd2ea074b992162",
            "input": "Intradiscal injection of triamcinolone hexacetonide for acute, subacute, and chronic sciatica.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-5092ae39f3704f5d869b10af94e78bc1",
            "input": "Symptomatic air trapped in the spine after lumbar epidural corticosteroid injection.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-a14b73c128404a2eb47baf2e71801fd5",
            "input": "The authors describe two patients with this disease who initially had findings suggestive of an optic neuropathy.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-83b6b5ef7d714bf8a425484835558f1b",
            "input": "These children aged 2.5-15 years were treated for Burkitt's lymphoma, Ewing's tumour, small cell bone tumour or medulloblastoma.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-c297c48709d74616b433211280a950ff",
            "input": "This is the first case of PML after SCT treated with cidofovir, and the fifth case treated with this drug in a patient without human immunodeficiency virus (HIV) infection.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-0b5a1c9d83074b27baec877834d237ad",
            "input": "Lamotrigine clearance increases throughout pregnancy, and maternal dose increases are often necessary to maintain therapeutic effect.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-734b09fcfa134506be2f9e079cde60d1",
            "input": "Use of leflunomide in an allogeneic bone marrow transplant recipient with refractory cytomegalovirus infection.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-59aa6f9309614a61b526046979a1aac2",
            "input": "Because of its favorable tolerability profile it appears to be a preferred alternative, especially in NSAID-sensitive patients.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-534d400f579c4be7b5bec3c738bdb327",
            "input": "A 57-year-old woman with end-stage renal disease presumed secondary to chronic glomerulonephritis underwent a living related renal allograft transplantation.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-721cce9ba84a46b3ab3a0e785289723d",
            "input": "We report the case of a 54-year old man with decompensated alcoholic liver cirrhosis and HIV infection who underwent liver transplantation (LT).",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-0a620f90880141ada3374e593c227284",
            "input": "Food and Drug Administration in 1989 for treatment of severely ill schizophrenic patients.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-08369b3b3ffc49819c685b25cad672fe",
            "input": "In turn, it may cause inflammation in such rapidly dividing tissues as the corneal epithelium, conjunctiva, and tear duct.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-aa6a45d3076d4690afcd073b65658855",
            "input": "The patient's platelet count dropped rapidly to a level of 1000/mm3 after receiving a single 600 mg dose of rifampin.",
            "output": [
                "non-adverse drug event"
            ]
        },
        {
            "id": "task1495-d08c3e3f6ec5442c8439d78cfc5e63a0",
            "input": "PURPOSE: To describe a case of progressive outer retinal necrosis in a human immunodeficiency virus-negative immunosuppressed patient undergoing treatment for graft-versus-host disease after bone marrow transplantation.",
            "output": [
                "non-adverse drug event"
            ]
        }
    ],
    "Instance License": [
        "Unknown"
    ]
}