diff --git "a/task50_biolord_explanation.json" "b/task50_biolord_explanation.json" new file mode 100644--- /dev/null +++ "b/task50_biolord_explanation.json" @@ -0,0 +1,36034 @@ +{ + "Contributors": [ + "BioLORD" + ], + "Source": [ + "BioLORD" + ], + "URL": [ + "https://huggingface.co/datasets/FremyCompany/BioLORD-Dataset" + ], + "Categories": [ + "Explanation" + ], + "Definition": [ + "Given a concise concept, generate a long detailed definition to explain it." + ], + "Reasoning": [], + "Input_language": [ + "English" + ], + "Output_language": [ + "English" + ], + "Instruction_language": [ + "English" + ], + "Domains": [ + "Medical Knowledge" + ], + "Positive Examples": [], + "Negative Examples": [], + "Instances": [ + { + "input": "Concept: Basal cell carcinoma, infundibulocystic (Neoplastic Process)", + "output": "Skin Basal Cell Carcinoma described as a rare type of basal cell carcinoma. It is characterized by multiple tiny cysts lined by infundibular epithelium." + }, + { + "input": "Concept: eosinophilic; gastroenteritis (Eosinophilic disorder)", + "output": "Disorder of small intestine described as gastroenteritis that is characterized by eosinophilic infiltration." + }, + { + "input": "Concept: Histone 2, H3d Gene (Gene or Genome)", + "output": "something described as human H3C13 wild-type allele is located in the vicinity of 1q21.2 and is approximately 1 kb in length. This allele, which encodes histone H3.2 protein, plays a role in the incorporation of DNA into nucleosomes." + }, + { + "input": "Concept: cinobufagin (Organic Chemical)", + "output": "Antineoplastic Agents described as a bufadienolide compound extracted from the dried venom secreted by the parotid glands of toads and one of the glycosides in the traditional Chinese medicine ChanSu, with potential antineoplastic activity. Although the mechanism of action of cinobufagin is still under investigation, it has been found to suppress cancer cell proliferation and cause apoptosis in cancer cells via a sequence of apoptotic modulators that include mitochondrial Bax and cytosolic chromosome c, and caspases 3, 8, and 9. Possible upstream mediators of cinobufagin-induced apoptosis include Fas and p53. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C95021\" active clinical trials using this agent." + }, + { + "input": "Concept: Mega-Trial (Research Activity)", + "output": "something described as massive trials that test the advantages of therapeutic interventions by enrolling 10,000 or more subjects." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Microbiology, Rapid Test, Urine Screening, Manual (IVD Test Reagent/Kits, Microbiology, Rapid Test, Urine Screening)", + "output": "Medical Device described as microbiology reagents used for rapid and qualitative determination (i.e., screening) of bacteria in urine samples, using manual procedures. The reagents may be liquid or included in sticks (e.g., dip sticks) that frequently can provide simultaneous information about the urine chemistry (e.g., bilirubin, ketone, glucose) and the presence of pus (pyuria)." + }, + { + "input": "Concept: Quality Of Life (Personal Attribute)", + "output": "health & life quality described as extent of positive perception of current life circumstances" + }, + { + "input": "Concept: Zero balancing(TM) each 30 minutes (Therapeutic or Preventive Procedure)", + "output": "something described as applying gentle acupressure, which focuses on a client's joints and bones to correct imbalances between energy and structure, to provide relief from his or her pain, anxiety and/or stress. Any practitioner using this code must document appropriate training and/or certification. Service is billed in 30-minute increments." + }, + { + "input": "Concept: H4K20me3 modified histone binding (methylated histone binding)", + "output": "methylated histone binding described as interacting selectively and non-covalently with a histone H4 in which the lysine residue at position 20 has been modified by trimethylation." + }, + { + "input": "Concept: oculomotor nerve structural organisation (cranial nerve structural organization)", + "output": "Organ or Tissue Function described as the process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." + }, + { + "input": "Concept: Microsurgery Chisels, Bone Outgrowth (Medical Device)", + "output": "Medical Device described as bone surgical chisels designed to excise bone outgrowths (i.e., osteophytes) during microsurgical procedures. These chisels are typically a small handheld, manual instrument including a straight or slightly curved flat blade with a one-sided beveled cutting edge and a knurled handle. Bone outgrowth microsurgical chisels are mainly used in delicate neurosurgical procedures of the spine, including lumbar discectomy." + }, + { + "input": "Concept: Ang 1-7 (Amino Acid, Peptide, or Protein)", + "output": "something described as a synthetic heptapeptide identical to endogenous angiotensin-(1-7) with vasodilator and antiproliferative activities. Therapeutic angiotensin 1-7 may inhibit cyclooxygenase 2 (COX-2) and the production of proinflammatory prostaglandins and may activate the angiotensin-(1-7) receptor Mas, resulting in diminished tumor cell proliferation. Activation of the angiotensin-(1-7) receptor Mas, a G-protein coupled, seven transmembrane protein, may down-regulate the phosphorylation and activation of Erk1 and Erk2 in the Erk1/Erk2 MAPK signaling pathway. In the renin-angiotensin system, the vasodilating activity of angiotensin- (1-7), hydrolysed from angiotensin II by the type I transmembrane metallopeptidase and carboxypeptidase angiotensin converting enzyme 2 (ACE2) in vivo, counteracts the vasoconstricting activity of angiotensin II." + }, + { + "input": "Concept: MMS204C (MMSE-2 Standard Version Functional Test Question)", + "output": "Intellectual Product described as mini-Mental State Examination 2 Standard Version (MMSE-2 Standard Version) What were those three words I asked you to remember: Word 3?" + }, + { + "input": "Concept: firefly luciferin luciferase activity (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen)", + "output": "luciferin monooxygenase activity described as catalysis of the reaction: O2 + ATP + Photinus luciferin = light + diphosphate + AMP + CO2 + oxidized Photinus luciferin." + }, + { + "input": "Concept: Turbidity (Chemical procedure)", + "output": "Laboratory Procedure described as a measurement of the opacity of a biological specimen." + }, + { + "input": "Concept: Meningococcal Conjugate Vaccine MCV4 (Vaccines, Conjugate)", + "output": "Immunologic Factor described as a conjugate vaccine of meningococcal polysaccharide used for active immunization against invasive meningococcal disease caused by Neisseria meningiditis serogroups A, C, Y, and W-135." + }, + { + "input": "Concept: NTKR2 Deficiency (Melanocortin Pathway Defect)", + "output": "something described as presumed loss-of-function mutation(s) in the NTKR2 gene, resulting in deficiency or dysfunction of the type 2 receptor for the enzyme neurotropic tyrosine kinase." + }, + { + "input": "Concept: intratendonous ossification (Molecular Function)", + "output": "Osteogenesis described as ossification wherein bone tissue forms within tendonous tissue." + }, + { + "input": "Concept: 2-MpP Phosphopeptide-tetanus Peptide Vaccine (Cancer Vaccines)", + "output": "something described as a vaccine composed of phosphorylated peptides from the tumor associated antigens breast cancer anti-estrogen resistance-3 (BCAR3) and insulin receptor substrate-2 (IRS2) and a tetanus-derived peptide, with potential immunomodulating and antineoplastic activities. Upon administration of pBCAR3/pIRS2 phosphopeptide-tetanus peptide vaccine, the pBCAR3/pIRS2 phosphopeptide may stimulate the immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing either phosphopeptide. The tetanus peptide serves as an immunoadjuvant and induces a helper T-cell response which may help stimulate an immune response against pBCAR3 and pIRS2-expressing melanoma tumor cells. BCAR3 and IRS2 are upregulated in a variety of cancer cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C107168\" active clinical trials using this agent." + }, + { + "input": "Concept: positive regulation of tonic skeletal muscle contraction (regulation of tonic skeletal muscle contraction)", + "output": "regulation of tonic skeletal muscle contraction described as any process that activates or increases the frequency, rate or extent of tonic skeletal muscle contraction." + }, + { + "input": "Concept: DSH (Family Felidae)", + "output": "something described as the name for a short-haired cat that does not have a pedigree nor belong to a specific cat breed. The domestic short-hair cat is a small carnivorous crepuscular mammal that has short fur length and is more slender and active than the domestic long-haired cat. It may have varied coat length and coat color in a single or multi-colored pattern. The domestic short-hair cat has a flexible, compact body and long tail that enhances balance, as well as keen eyesight and retractable claws. The female cat exhibits high fecundity; sexual maturation in the female occurs between 6-12 months of age, producing up to 3 litters of 4-8 kittens per year. Male domestic long-hair cats become sexually mature at 9-22 months. The gestational period of the cat embryo is 63-65 days and the average lifespan of a domestic short haired cat is 10-15 years. The domestic short-hair cat is used most commonly in medical research involving viral pathogenesis and vaccination studies." + }, + { + "input": "Concept: temperatureCapabilityRange (Range)", + "output": "Quantitative Concept described as an integer falling within minimum and maximum bounds that specifies the temperature capability of the system." + }, + { + "input": "Concept: anus; injury (Pelvic injury)", + "output": "something described as trauma to the anus." + }, + { + "input": "Concept: peptidyl-L-beta-methylthioasparagine synthesis from peptidyl-asparagine (Molecular Function)", + "output": "peptidyl-asparagine modification described as the modification of peptidyl-asparagine to form peptidyl-L-beta-methylthioasparagine, typical of bacterial ribosomal protein S12." + }, + { + "input": "Concept: FACT/GOG-NTX Version 4 - I Feel Discomfort in My Hands (Intellectual Product)", + "output": "Intellectual Product described as functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity Version 4 (FACT/GOG-NTX Version 4) Additional Concerns: I feel discomfort in my hands." + }, + { + "input": "Concept: I 6.2 (Technion ES Cell Line)", + "output": "something described as provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers." + }, + { + "input": "Concept: Invalid Reason (Indication of)", + "output": "Idea or Concept described as why something is not recognized or acceptable for a purpose." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Coxsackievirus B, RNA (Medical Device)", + "output": "something described as molecular assay reagents intended to identify Coxsackievirus group B, a single-stranded RNA virus of a subgroup of the genus Enterovirus, family Picornaviridae, by detecting the ribonucleic acid (RNA) of the target virus. This virus may cause diseases resembling poliomyelitis, febrile illness, and/or aseptic meningitis." + }, + { + "input": "Concept: VFQ25-Interviewer Administered Format - Difficulty Reading Small Print (Intellectual Product)", + "output": "Intellectual Product described as visual Functioning Questionnaire 25-Interviewer Administered Format Version 2000 (VFQ25-Interviewer Administered Format) Near Vision: Wearing glasses, how much difficulty do you have reading the small print in a telephone book, on a medicine bottle, or on legal forms? Would you say:" + }, + { + "input": "Concept: enteroendocrine cell differentiation (Cell Function)", + "output": "Cell Function described as the process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system." + }, + { + "input": "Concept: Therapy, Animal Assisted (Psychotherapy)", + "output": "Rehabilitation therapy described as purposeful use of animals to provide affection, attention, diversion, and relaxation" + }, + { + "input": "Concept: Saccular aneurysm (Dilatation of the cerebral artery)", + "output": "Aneurysm described as a small, sac-like aneurysm (outpouching) of a cerebral blood vessel." + }, + { + "input": "Concept: frontonasal suture morphogenesis (craniofacial suture morphogenesis)", + "output": "Organ or Tissue Function described as the process in which the frontonasal suture, between frontal and nasal bones, is generated and organized." + }, + { + "input": "Concept: inositol-2,4,5,6-tetrakisphosphate 5-phosphatase activity (Molecular Function)", + "output": "inositol tetrakisphosphate phosphatase activity described as catalysis of the reaction: 1D-myo-inositol 2,4,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 2,4,6-trisphosphate + phosphate." + }, + { + "input": "Concept: Distal interphalangeal joint (Joint structure of digit)", + "output": "Body Space or Junction described as interphalangeal joint located between the second and third phalanges." + }, + { + "input": "Concept: SYSTEM, TEST, OSTEOCALCIN (Medical Device)", + "output": "something described as an alkaline phosphatase or isoenzymes test system is a device intended to measure alkaline phosphatase or its isoenzymes (a group of enzymes with similar biological activity) in serum or plasma. Measurements of alkaline phosphatase or its isoenzymes are used in the diagnosis and treatment of liver, bone, parathyroid, and intestinal diseases." + }, + { + "input": "Concept: p53 Gene, Ad5CMV (Pharmacologic Substance)", + "output": "Gene Therapy Agent described as a replication-defective adenoviral-CMV vector that encodes a wild-type p53 gene. Ad5CMV-p53 induces tumor cells that have been transfected with the vector to produce wild-type p53, a tumor suppressor gene that is deleted or mutated in a significant number of cancers. In transfected tumor cells, the wild-type p-53 gene product exerts an antitumor effect by blocking cell cycle progression at the G1/S regulation point, activating DNA repair proteins in the presence of DNA damage, and initiating apoptosis when DNA damage is irreparable. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2471\" active clinical trials using this agent." + }, + { + "input": "Concept: MIRN432 (Gene or Genome)", + "output": "MicroRNA Gene described as this gene is involved in the regulation of gene expression and plays a role in the development of epithelial ovarian carcinoma." + }, + { + "input": "Concept: Abnormal wrist bones (Hand deformities)", + "output": "Hand deformities described as an abnormality affecting the carpal bones of the wrist (scaphoid, lunate, triquetral, pisiform, trapezium, trapezoid, capitate, hamate)." + }, + { + "input": "Concept: 2-Amino-9-((2-isopropoxy-1-(isopropoxymethyl)ethoxy)methyl)purine (Purine antagonist)", + "output": "Pharmacologic Substance described as a purine nucleoside prodrug with activity against herpes simplex virus 1. In vivo, Rociclovir is converted to ganciclovir, which is further modified to its triphosphate form and inhibits viral DNA replication by competitive inhibition of viral DNA polymerases and incorporation into viral DNA, resulting in eventual termination of viral DNA elongation." + }, + { + "input": "Concept: 1q24-q25 (Chromosome band)", + "output": "something described as a chromosome band present on 1q" + }, + { + "input": "Concept: 15S Mg(2+)-ATPase P97 Subunit (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as transitional endoplasmic reticulum ATPase (806 aa, ~89 kDa) is encoded by the human VCP gene. This protein is involved in maintaining the Golgi during and after mitosis and the the formation of the transitional endoplasmic reticulum." + }, + { + "input": "Concept: Mineral - dietary (Nutrients)", + "output": "Minerals described as general term for all inorganic dietary constituents; do not confuse with DIETARY SODIUM, which should be used to index dietary \"table salt\" (sodium chloride)." + }, + { + "input": "Concept: Breast Carcinoma Pathologic Primary Tumor TNM Finding v7 (Finding)", + "output": "Finding described as a pathologic finding about one or more characteristics of breast cancer, following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor. The TNM pathologic and clinical primary tumor classifications of breast cancer are the same, regardless of whether they are based on pathologic and/or clinical criteria." + }, + { + "input": "Concept: Centralz Test Cat (Intellectual Product)", + "output": "Document type described as a Category name for the eTMF domain used to classify a collection of documents related to central laboratory research and reporting for clinical trials." + }, + { + "input": "Concept: Communicating with - receiving - drawings and photographs (Social Behavior)", + "output": "Communicating with - receiving - nonverbal messages described as comprehending the meaning represented by drawings (e.g. line drawings, graphic designs, paintings, three-dimensional representations), graphs, charts and photographs, such as understanding that an upward line on a height chart indicates that a child is growing." + }, + { + "input": "Concept: anti-hiv therapy (Antiretroviral therapy)", + "output": "something described as treatment of human immunodeficiency virus (HIV) infections with medications that target the virus directly, limiting the ability of infected cells to produce new HIV particles." + }, + { + "input": "Concept: Kluyvera cochleae Muller et al. 1996 (Kluyvera)", + "output": "Kluyvera described as a species of facultatively anaerobic, Gram negative, rod shaped bacteria assigned to the phylum Proteobacteria. This species is motile by peritrichous flagella, catalase positive, oxidase and indole negative, and ferments sucrose, dulcitol and amygdalin. K. intermedia is commonly found in surface water and may be an opportunistic pathogen." + }, + { + "input": "Concept: primary granule (Primary lysosome)", + "output": "Cell Component described as primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." + }, + { + "input": "Concept: Douche Sol (Irrigation Solution)", + "output": "something described as a solution intended for use as a vaginal irrigant." + }, + { + "input": "Concept: Study Agent Status Code (Code)", + "output": "Code described as a coded value specifying the phase in the lifecycle of the agent's association to a study. EXAMPLE(S): pending, active, complete, cancelled" + }, + { + "input": "Concept: Rahnella aquatilis Izard et al. 1981 (Bacterium)", + "output": "Rahnella described as a species of facultatively anaerobic, Gram negative, rod shaped bacteria in the phylum Fusobacteria. This species is weakly positive for phenylalanine deaminase. R. aquatilis is pathogenic in immunocompromised patients." + }, + { + "input": "Concept: Informed Consent Template (Document type)", + "output": "something described as a document approved by the Institutional Review Board (IRB) or Independent Ethics Committee (IEC) which explains all relevant study information to assist the study volunteer in understanding the expectations and requirements of participation in a clinical trial; may include Assent for minors." + }, + { + "input": "Concept: mitotic spindle pole body localization (Cell Function)", + "output": "Cell Function described as a process in which a mitotic spindle pole body is transported to, or maintained in, a specific cellular location." + }, + { + "input": "Concept: Increased proportion of CD19+CD38+IgM+ cells (Finding)", + "output": "something described as an elevation in the normal proportion of transitional B cells (CD19+/CD38high/IgMhigh) in circulation relative to the total number of B cells. B cells originate from precursors in the bone marrow, and the first cells which migrate to the peripheral blood have been classified as transitional B cells." + }, + { + "input": "Concept: Microgram per Milliliter per Hour (Unit of Dose Calculation)", + "output": "something described as a dose calculation unit expressed in microgram(s) per milliliter of solution per period of time equal to sixty minutes." + }, + { + "input": "Concept: auritas, Aurelia (Aurelia)", + "output": "Aurelia described as species of the most widely recognized jellyfish; in the family Ulmaridae, order Semaeostomeae." + }, + { + "input": "Concept: Wnt receptor signaling pathway, calcium modulating pathway (non-canonical Wnt signaling pathway)", + "output": "non-canonical Wnt signaling pathway described as the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." + }, + { + "input": "Concept: WHODAS 2.0 36-item Version Proxy-administered - Sexual Activities (WHODAS 2.0 36-item Version Proxy-administered Questionnaire Question)", + "output": "Intellectual Product described as world Health Organization Disability Assessment Schedule 2.0 36-item Version Proxy-administered (WHODAS 2.0 36-item Version Proxy-administered) Because of their health condition, in the past 30 days, how much difficulty did your relative have in: Sexual activities?" + }, + { + "input": "Concept: Albiglutide (A [Preparations])", + "output": "Antidiabetics described as a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist, with antihyperglycemic activity. Albiglutide is composed of a GLP-1 (7-36) dimer fused to recombinant human albumin. Upon subcutaneous administration, this agent has a half-life of 4-7 days and resists degradation by dipeptidyl peptidase-4 (DPP-4)." + }, + { + "input": "Concept: Impaired ristocetin cofactor assay activity (Finding)", + "output": "Abnormality of von Willebrand factor described as abnormal response to ristocetin as manifested by reduced or lacking aggregation of platelets upon addition of ristocetin to platelet-poor plasma." + }, + { + "input": "Concept: Hydratases, Epoxide (Amino Acid, Peptide, or Protein)", + "output": "Enzyme described as enzymes that catalyze reversibly the formation of an epoxide or arene oxide from a glycol or aromatic diol, respectively." + }, + { + "input": "Concept: Generalized Muscle Weakness (Finding)", + "output": "something described as a disorder characterized by a reduction in the strength of muscles in multiple anatomic sites." + }, + { + "input": "Concept: DRRI1E02 (Intellectual Product)", + "output": "something described as deployment Risk and Resilience Inventory-2 (DRRI-2) During deployment: I saw refugees who had lost their homes or belongings." + }, + { + "input": "Concept: STAT1 deficiency (Autosomal recessive hereditary disorder)", + "output": "Autosomal recessive hereditary disorder described as a rare genetic primary immunodeficiency due to a defect in innate immunity disorder with characteristics of impaired intracellular signaling from both type I and type II interferons, leading to early-onset, severe, life-threatening intracellular bacterial (typically mycobacteria) and viral (mainly herpes viruses) infections. Caused by homozygous mutation in the STAT1 gene on chromosome 2q32." + }, + { + "input": "Concept: Free from harm related to medications administered within the perioperative environment (Safety)", + "output": "Finding described as the correct patient receives the correct medication(s) in accurate dose(s), at the correct time, and via the correct route with the desired effect throughout the perioperative experience." + }, + { + "input": "Concept: coenzyme A transmembrane transporter activity (adenosine 3',5'-bisphosphate transmembrane transporter activity)", + "output": "Molecular Function described as enables the transfer of coenzyme A from one side of a membrane to the other. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." + }, + { + "input": "Concept: EPHA5 gene (Gene or Genome)", + "output": "something described as this gene is involved in brain development." + }, + { + "input": "Concept: Dyspraxia syndrome (Nervous system problem)", + "output": "Nervous system problem described as a kind of neurological disorder characterized by loss of the ability to perform voluntary and skillful movements" + }, + { + "input": "Concept: GAIA Preeclampsia Level of Diagnostic Certainty Terminology (GAIA Terminology)", + "output": "something described as a subset of terminology related to preeclampsia, developed by the Global Alignment of Immunization safety Assessment in pregnancy consortium to aid in monitoring and improving fetal and maternal outcomes." + }, + { + "input": "Concept: CD3E-Associated Protein (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as DNA-directed RNA polymerase I subunit RPA34 (510 aa, ~55 kDa) is encoded by the human CD3EAP gene. This protein plays a role in the transcription of DNA into RNA." + }, + { + "input": "Concept: Cutaneous Squamous Cell Carcinoma or Other Cutaneous Carcinomas pN2c TNM Finding v7 (Skin Squamous Cell Carcinoma or Other Skin Carcinomas pN2 TNM Finding v7)", + "output": "Finding described as skin squamous cell carcinoma or other skin carcinomas with metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension." + }, + { + "input": "Concept: Lip and Oral Cavity Cancer cM1 TNM Finding v7 (Finding)", + "output": "Lip and Oral Cavity Cancer Clinical Distant Metastasis TNM Finding v7 described as lip and oral cavity cancer with distant metastasis." + }, + { + "input": "Concept: otic placode formation (ectodermal placode formation)", + "output": "something described as the initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain." + }, + { + "input": "Concept: Coxiellaceae (Legionellales)", + "output": "Legionellales described as a family of gram-negative bacteria in the order Legionellales. It includes genera COXIELLA and Rickettsiella." + }, + { + "input": "Concept: Unknown Primary Tumor pNX TNM Finding v8 (Unknown Primary Tumor Pathologic Cervical Lymph Nodes TNM Finding v8)", + "output": "something described as unknown primary tumor in which the regional lymph nodes cannot be assessed." + }, + { + "input": "Concept: integral component of endosome membrane (Cell Component)", + "output": "something described as the component of the endosome membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." + }, + { + "input": "Concept: Stage III Oropharyngeal Undifferentiated Carcinoma AJCC v7 (Oropharyngeal squamous cell carcinoma stage III)", + "output": "Oropharyngeal lymphepithelioma described as stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T1: Tumor 2 cm or less in greatest dimension. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor measuring more than 4 centimeters in greatest dimension or extension to lingual surface of epiglottis. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis." + }, + { + "input": "Concept: transmembrane signalling receptor activity (signaling receptor activity)", + "output": "Molecular Function described as combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." + }, + { + "input": "Concept: pT4 Cancer of the Stomach v6 (Gastric Cancer Pathologic Primary Tumor TNM Finding v6)", + "output": "Finding described as gastric cancer with tumor invading into adjacent structures of the stomach which include the spleen, transverse colon, liver, diaphragm, pancreas, abdominal wall, adrenal gland, kidney, small intestine, and retroperitoneum. Intramural extension into the esophagus or duodenum is classified by the depth of the greatest invasion in any of these sites, including the stomach." + }, + { + "input": "Concept: spastic infantile paralysis (cerebral degenerations, extrapyramidal and movement disorders)", + "output": "Central Nervous System described as a type of cerebral palsy characterized by spasticity and hypertonia of the lower extremities bilaterally, particularly the legs, hips, and pelvis; this is the most common (70%) form of cerebral palsy." + }, + { + "input": "Concept: Thrombocytocrit (Laboratory Procedure)", + "output": "Hematology procedure described as a relative measurement (ratio or percentage) of the proportion of the volume of blood taken up by platelets." + }, + { + "input": "Concept: cellular response to nitrosative stress (Cell Function)", + "output": "response to nitrosative stress described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions." + }, + { + "input": "Concept: Grade 4 Dysphagia (Dysphagia, CTCAE)", + "output": "Finding described as life-threatening consequences; urgent intervention indicated" + }, + { + "input": "Concept: mkat (Unit of Catalytic Activity)", + "output": "Quantitative Concept described as a unit of catalytic activity measurement equal to one thousandth of one katal (1E-3 katal)." + }, + { + "input": "Concept: Protein Degradations (Proteolysis)", + "output": "Protein Metabolism Process described as proteolysis typically involves hydrolysis of specific peptide bond(s) with formation of smaller polypeptides in a target protein during maturation or modification of functional activity. The process may be catalyzed by proteolytic enzymes, by acids, or by bases." + }, + { + "input": "Concept: 3-Phosphoglycerate Kinase (Phosphotransferases)", + "output": "something described as a family of enzymes that catalyzes the transfer of a phosphate group from 1,3-bisphosphoglycerate (1,3-BPG) to adenosine diphosphate (ADP) yielding 3-phosphoglycerate (3-PG) and adenosine triphosphate (ATP) and also catalyzes the reverse reaction that transfers a phosphate group from ATP to 3-PG yielding 1,3-BPG and ADP." + }, + { + "input": "Concept: TRYPARSAMIDE (Pharmacologic Substance)", + "output": "Organic Chemical described as an arsenic compound with activity against Spirochaetes bacteria. Tryparsamide is used in the treatment of syphilis and African sleeping sickness." + }, + { + "input": "Concept: Ultrasonic (Sound - physical agent)", + "output": "Physical Phenomenon or Property described as high frequency sound, generally with a frequency greater than 20,000 Hz." + }, + { + "input": "Concept: downregulation of gap junction assembly (negative regulation of cell junction assembly)", + "output": "Cell Function described as any process that stops, prevents or reduces the frequency, rate or extent of gap junction assembly." + }, + { + "input": "Concept: Fatty acid level (Lipids measurement)", + "output": "Lipids measurement described as the determination of the amount of fatty acids present in a sample." + }, + { + "input": "Concept: Statistical Measurement (Measurement)", + "output": "something described as process of or products derived from the collection or manipulation of statistical data in order to derive basic summarizing quantitative values which describe a set of measurements." + }, + { + "input": "Concept: Five Minutes After Birth (Time)", + "output": "Temporal Concept described as the actual time that is five minutes after the birth of a fetus. This period is most commonly referenced during the administration of the Apgar test." + }, + { + "input": "Concept: Extremely low birth weight infant (Neonatal disorder)", + "output": "Neonatal disorder described as an infant whose weight at birth is less than 1000 grams (2.2 lbs), regardless of GESTATIONAL AGE." + }, + { + "input": "Concept: area 5 of Peele-1942 (Body Location or Region)", + "output": "something described as a cortical area in the parietal lobe defined on the basis of cytoarchitecture in the rhesus macaque (Macaca mulatta). The author regarded it as the same as area 5 of Brodmann (guenon). The cortical thickness was 1.62 mm. The molecular layer of the cerebral cortex (I) was wider than in the postcentral gyrus and contained only a few spindle cells and granule cells. The external granular layer (II) was about 8 to 10 cells deep with granule cells larger than in layer IV; an occasional very small pyramidal cell was seen. Cells in the external pyramidal layer (III) were pyramidal cells that were striking in size progression from smaller to very large in the deepest of three sublayers; it differed from area 7 of Peele in that the cells were not arranged in a radial pattern. The internal granular layer (IV) was about 15 cells thick with distinct outer and inner boundaries; it was composed predominantly of very small granule cells. The internal pyramidal layer (V) was ill-defined and contained medium to large pyramidal cells. The multiform layer (VI) was quite wide and separated from layer V by a cell-poor zone; it contained medium sized granule cells, small pyramidal cells and spindle cells of medium size ( Peele-1942 )." + }, + { + "input": "Concept: Allergic migraine (Disease or Syndrome)", + "output": "Migraine Disorders described as migraine triggered by an allergic inflammatory process." + }, + { + "input": "Concept: Planned Criterion Group Option Relationship Priority Number (Intellectual Product)", + "output": "something described as an integer specifying the relative preference for considering this relationship before other similar relationships having the same source activity." + }, + { + "input": "Concept: FAC018-I Feel Close to My Partner (FACT-LYM Version 4 Questionnaire Question)", + "output": "FACT-LYM Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Lymphoma Version 4 (FACT-LYM Version 4) Social/Family Well-Being: I feel close to my partner (or the person who is my main support)." + }, + { + "input": "Concept: MOAB Di-dgA-RFB4 (Immunologic Factor)", + "output": "Pharmacologic Substance described as an anticancer drug that is a combination of a monoclonal antibody (RFB4) and an immunotoxin (dgA)." + }, + { + "input": "Concept: Grade 4 Fetal growth retardation (Fetal Growth Retardation, CTCAE)", + "output": "Fetal Growth Retardation, CTCAE described as <1% percentile of weight for gestational age" + }, + { + "input": "Concept: Chemokine (C-X-C Motif) Ligand 6 Measurement (Chemokine Measurement)", + "output": "Chemokine Measurement described as the determination of the amount of chemokine (C-X-C Motif) ligand 6 present in a sample." + }, + { + "input": "Concept: Nasal Sinuses (Paranasal sinus part)", + "output": "something described as the air-filled cavities adjacent to the nasal cavity lined by a mucous membrane and located in the bones of the skull." + }, + { + "input": "Concept: Lymphatic Filariasis (Lymphatic Diseases)", + "output": "Parasite infestation described as a clinical disorder that is caused by obstruction of the lymphatic system years after filarial infection. It is characterized by painful and profound lymphedema, resulting in significant swelling (elephantiasis) of extremities and genitals." + }, + { + "input": "Concept: Max Excretion Rate Norm by SA (Quantitative Concept)", + "output": "something described as the maximum excretion rate divided by the surface area." + }, + { + "input": "Concept: Implant-Abutment Design, Dental (Dental Prosthesis Design)", + "output": "something described as the plan and delineation of DENTAL IMPLANT fitting with DENTAL ABUTMENT." + }, + { + "input": "Concept: Clinical Endpoint BE Studies v1.0 (FDA Technical Specification Name and Version)", + "output": "Intellectual Product described as version 1.0 of the FDA Clinical Endpoint BE Studies Technical Specifications Guidance." + }, + { + "input": "Concept: Anti-CD3 x Anti-CD38 Bispecific Monoclonal Antibody AMG 424 (Anti-CD38 Monoclonal Antibody)", + "output": "Antineoplastic Antibody described as a humanized, bispecific monoclonal antibody (BsAb) targeting CD3, a T-cell surface antigen, and CD38, a human cell surface glycoprotein and tumor-associated antigen (TAA), with potential antineoplastic activity. Upon intravenous administration, anti-CD3/CD38 bispecific monoclonal antibody AMG 424 binds to both CD3 on T cells and CD38 expressed on tumor cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies; its expression has been correlated with poor prognosis." + }, + { + "input": "Concept: VFQ2-Eye Pain Keep From Doing What Like (VFQ25-Self Administered Format Questionnaire Question)", + "output": "something described as visual Functioning Questionnaire 25-Self Administered Format Version 2000 (VFQ25-Self Administered Format) Responses to Vision Problems: How much does pain or discomfort in or around your eyes, for example, burning, itching, or aching, keep you from doing what you'd like to be doing? Would you say:" + }, + { + "input": "Concept: Spinocerebellar ataxia type 26 (Disease or Syndrome)", + "output": "Disease or Syndrome described as a very rare subtype of autosomal dominant cerebellar ataxia type 3 with characteristics of late-onset and slowly progressive cerebellar signs (gait ataxia) and eye movement abnormalities. To date, only 23 affected patients have been described from one American family of Norwegian descent. Disease onset occurs between the ages of 26-60. A candidate gene has recently been identified as the eukaryotic translation elongation factor 2 (EEF2) gene, located on chromosome 19p13.3. Inherited autosomal dominantly." + }, + { + "input": "Concept: Significant Arterial Dissection (Aneurysm, Dissecting)", + "output": "Disease or Syndrome described as a dissection that impairs flow. This includes Type C (a persisting contrast medium extravasation) in the presence of ischemia, Type D (a spiral filling defect with delayed but complete distal flow), Type E (persistent filling defect with delayed antegrade flow) and Type F (filling defect with impaired flow and total occlusion)." + }, + { + "input": "Concept: ooplasm (Cytoplasm)", + "output": "Cell Component described as the specialized cytoplasm in an oocyte." + }, + { + "input": "Concept: H&E Stain (Microbial staining)", + "output": "ObservationMethod - CodeSystem described as a microscopy staining method that utilizes two separate dyes, one staining the nucleus and the other staining the cytoplasm and connective tissue. Hematoxylin is a dark purplish dye that stains the chromatin (nuclear material) within the nucleus. Eosin is an orangish-pink to red dye that stains the cytoplasmic material including connective tissue and collagen." + }, + { + "input": "Concept: peripheral nerve block (Injection of peripheral nerve)", + "output": "Injection into peripheral nerve described as the injection of medications near peripheral nerves to decrease pain and inflammation." + }, + { + "input": "Concept: RELSUB (Intellectual Product)", + "output": "something described as terminology associated with the relationship to subject codelist of the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: Autologous Activated Cytotoxic T Lymphocytes/Natural Killer Cells (Cell)", + "output": "Antineoplastic Immune Cell described as a preparation of cytotoxic, autologous lymphoid effector cells specifically targeted towards tumor cells, with potential immunomodulating and antineoplastic activities. The autologous lymphoid effector cells are prepared by drawing a blood sample containing the required precursors for CD4+ helper T-cells, CD8+ cytotoxic T-cells, and natural killer (NK) cells from a cancer patient. The precursor cells are activated, selected and expanded to generate mature autologous lymphoid effector cells with the potential for enhanced tumor recognition. Upon readministration into the patient, the autologous lymphoid effector cells may induce both humoral and cellular immune responses against tumor cells. This may result in the immune-mediated inhibition of tumor cell proliferation, which leads to tumor cell death." + }, + { + "input": "Concept: ABL2 Gene Rearrangement (Chromosome 1 Abnormality)", + "output": "something described as a molecular abnormality indicating rearrangement of the ABL2 gene." + }, + { + "input": "Concept: brachyury-expressing yeast vaccine GI-6301 (Immunologic Factor)", + "output": "Pharmacologic Substance described as a cancer vaccine composed of a heat-killed, recombinant form of the yeast Saccharomyces cerevisiae that is genetically modified to express the transcription factor brachyury protein, with potential antineoplastic activity. Upon subcutaneous administration, the brachyury-expressing yeast vaccine GI-6301 is recognized by dendritic cells, processed, and presented by Class I and II MHC molecules on the dendritic cell surface. This elicits a targeted CD4+ and CD8+ T-lymphocyte-mediated immune response. This process kills brachyury-expressing tumor cells. Brachyury is overexpressed in a variety of tumor types and plays an important role in cancer progression and metastasis." + }, + { + "input": "Concept: hypersensitivity vasculitis (Examiner's Diagnosis)", + "output": "Vasculitis, Leukocytoclastic, Cutaneous described as disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. Its pathophysiology includes immune complex deposition and a wide range of skin lesions. Hypersensitivity or allergy is present in some but not all cases." + }, + { + "input": "Concept: spinal cord interneuron axon guidance (interneuron axon guidance)", + "output": "interneuron axon guidance described as the process in which the migration of an axon growth cone of a spinal cord interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A spinal cord interneuron is a CNS interneuron located in the spinal cord." + }, + { + "input": "Concept: virus multiplication (virus infection mechanism)", + "output": "Cell Function described as process of forming progeny virus from input virus; involves expression and replication of viral genomic nucleic acid and the assembly of progeny virus particles." + }, + { + "input": "Concept: protocatechuate degradation (3,4-dihydroxybenzoate metabolic process)", + "output": "3,4-dihydroxybenzoate metabolic process described as the chemical reactions and pathways resulting in the breakdown of 3,4-dihydroxybenzoate." + }, + { + "input": "Concept: RSTESTCD (Test Code)", + "output": "Test Code described as a character or string that represents the short code name of the disease response assessment." + }, + { + "input": "Concept: Respiratory (RouteByMethod)", + "output": "Drug Administration Routes described as in medicine, refers to the act of taking a substance into the body by breathing." + }, + { + "input": "Concept: Neurocutaneous Disorder (Skin lesion)", + "output": "Disease or Syndrome described as a hereditary syndrome affecting the central nervous system that is associated with lesions of the skin and retina. Representative examples include neurofibromatosis, tuberous sclerosis, von Hippel-Lindau syndrome, and Sturge-Weber syndrome." + }, + { + "input": "Concept: ERT - Number Stimuli Portraying Sadness (ERT Functional Test Question)", + "output": "Intellectual Product described as emotion Recognition - Number of stimuli defined as portraying sadness." + }, + { + "input": "Concept: Xe element (General anesthetic drugs)", + "output": "X [Preparations] described as noble gas with atomic symbol Xe, atomic number 54; found in the earth's atmosphere; has been used as an anesthetic." + }, + { + "input": "Concept: REHABIL NURS (Biomedical Occupation or Discipline)", + "output": "Care given by nurses described as a nursing specialty involved in the diagnosis and treatment of human responses of individuals and groups to actual or potential health problems with the characteristics of altered functional ability and altered life-style." + }, + { + "input": "Concept: Selective Immunoglobulin Isotype Deficiency (Humoral immune defect)", + "output": "Humoral immune defect described as a broad classification of dysgammaglobulinemias characterized by low or undetectable serum levels of one of the five immunoglobulin classes. Deficiencies of immunoglobulins present variably according to isotype. Selective deficiencies may be caused by decreased or inefficient production from progenitor B cells without any corresponding decreases in the other isotypes. The clinical course and prognosis is dependent upon the severity of the selective deficiency and associated morbidity." + }, + { + "input": "Concept: Neurologic Degenerative Condition (nervous system disorder)", + "output": "Nervous system disorders NEC described as hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures." + }, + { + "input": "Concept: cellular response to L-phenylalanine derivative (response to L-phenylalanine derivative)", + "output": "cellular response to organonitrogen compound described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-phenylalanine derivative stimulus." + }, + { + "input": "Concept: Abnormality of the cerebrum (Anatomical Abnormality)", + "output": "something described as any structural abnormality of the telencephalon, which is also known as the cerebrum." + }, + { + "input": "Concept: Strain Stock Identifier (Identifier)", + "output": "something described as a sequence of letters, numbers, or other characters that specifically identifies a particular strain stock." + }, + { + "input": "Concept: MET Kinase Inhibitor OMO-1 (Organic Chemical)", + "output": "Pharmacologic Substance described as an inhibitor of the proto-oncogene and receptor tyrosine kinase (RTK) hepatocyte growth factor receptor (c-Met; HGFR; MET) with potential antineoplastic activity. Upon administration, OMO-1 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C148537\" active clinical trials using this agent." + }, + { + "input": "Concept: zinc homeostasis (divalent inorganic cation homeostasis)", + "output": "Organism Function described as any process involved in the maintenance of an internal steady state of zinc ions within an organism or cell." + }, + { + "input": "Concept: MSQL1-Trouble Keep Attention for Long (Intellectual Product)", + "output": "MSQOL-54 Questionnaire Question described as multiple Sclerosis Quality of Life-54 Instrument - How much of the time during the past 4 weeks: Did you have trouble keeping your attention on an activity for long?" + }, + { + "input": "Concept: C1GALT (Gene or Genome)", + "output": "Gene or Genome described as human C1GALT1 wild-type allele is located in the vicinity of 7p21.3 and is approximately 92 kb in length. This allele, which encodes glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 protein, plays a role in mucin-type O-glycan metabolism." + }, + { + "input": "Concept: snoRNA splicing (RNA Splicing)", + "output": "something described as the process of removing sections of a primary snoRNA transcript to remove sequences not present in the mature form of the snoRNA and joining the remaining sections to form the mature form of the snoRNA." + }, + { + "input": "Concept: cellular response to oxygen molecular entity (cellular response to chemical stimulus)", + "output": "Cell Function described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus." + }, + { + "input": "Concept: D-alanine-alanyl-poly(glycerolphosphate) ligase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the ATP-dependent activation of D-alanine and its transfer as a thiol ester to the phosphopantheinyl prosthetic group of a D-alanyl carrier protein, according to the reaction: ATP + D-alanine + a [D-alaninyl carrier protein] = a D-alanyl-[D-alanyl carrier protein] + AMP + diphosphate." + }, + { + "input": "Concept: acetyl-CoA:2-arylethylamine N-acetyltransferase activity (Molecular Function)", + "output": "N-acetyltransferase activity described as catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine." + }, + { + "input": "Concept: endo-1,3-alpha-D-glucanase activity (glucosidase activity)", + "output": "something described as catalysis of the endohydrolysis of (1->3)-alpha-D-glucosidic linkages in isolichenin, pseudonigeran and nigeran." + }, + { + "input": "Concept: Ubiquitin-Protein Ligase D2 (Enzyme)", + "output": "something described as ubiquitin-conjugating enzyme E2 D2 (147 aa, ~17 kDa) is encoded by the human UBE2D2 gene. This protein is involved in the covalent attachment of ubiquitin to protein substrates." + }, + { + "input": "Concept: inotropes enoximone (E [Preparations])", + "output": "Ketones described as a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. It is used in patients with CONGESTIVE HEART FAILURE." + }, + { + "input": "Concept: CDISC Prostate Cancer Therapeutic Area User Guide Version 1.0 (Intellectual Product)", + "output": "something described as the 1.0 version of the CDISC Prostate Cancer therapeutic area user guide." + }, + { + "input": "Concept: tribe (Organic Chemical)", + "output": "Organic Chemical described as vesicaria, tribe." + }, + { + "input": "Concept: Non-distal deletion 12q (Disease or Syndrome)", + "output": "Disease or Syndrome described as a partial autosomal monosomy with characteristics of a variable combination of developmental delay, intellectual disability, ectodermal, genitourinary and minor cardiac anomalies and specific dysmorphic features (prominent forehead and low-set ears). Specific combination depends on the size and breakpoints of deleted regions." + }, + { + "input": "Concept: Aspartate kinase (Enzyme)", + "output": "Enzyme described as an enzyme that catalyzes the formation of beta-aspartyl phosphate from aspartic acid and ATP. Threonine serves as an allosteric regulator of this enzyme to control the biosynthetic pathway from aspartic acid to threonine. EC 2.7.2.4." + }, + { + "input": "Concept: EBOV Specific IgG AB Secreting Cells (Cell Count)", + "output": "something described as the determination of the number of Ebola virus-specific IgG antibody secreting cells in a biological sample." + }, + { + "input": "Concept: Irregular, lacy iliac crests (Irregular iliac crest)", + "output": "Pelvis described as irregularities of the iliac crest that produce the appearance of a lace border around it." + }, + { + "input": "Concept: Living with Sibling (Living Arrangements)", + "output": "Finding described as an indication that an individual lives with their sibling." + }, + { + "input": "Concept: Viscera set (Body Regions)", + "output": "General anatomical term described as general anatomical term that refers to any organ that is located within the body cavity (or in its extension, in the scrotum); it consists of organ parts that are embryologically derived from endoderm, splanchnic mesoderm or intermediate mesoderm; together with other organs, the viscus constitutes the respiratory, gastrointestinal, urinary, reproductive and immune systems, or is the central organ of the cardiovascular system. Examples: heart, lung, esophagus, kidney, ovary, spleen." + }, + { + "input": "Concept: Hour Times Nanogram per Milliliter per Meter Squared (Quantitative Concept)", + "output": "Measurement Unit Description described as hours times nanograms per milliliter (area under the curve), divided by meters squared (surface area)." + }, + { + "input": "Concept: drug design/synthesis/production (technology/technique development)", + "output": "Phenomenon or Process described as drug (or potential drug) synthesis or development; includes production of drugs, hormones, and related chemicals; some projects may include DRUG DISCOVERY/ISOLATION; for development of non-drug substances such as radiotracers see TECHNOLOGY/TECHNIQUE DEVELOPMENT." + }, + { + "input": "Concept: 90Y-DOTA-biotin (Radioconjugate)", + "output": "something described as a radioconjugate of biotin and yttrium Y 90 (Y-90) linked through the bifunctional macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) with radioimmunotherapy property. Biotin is a water-soluble B-complex vitamin, present in minute amounts in every living cell, while its level in cancerous tissue is higher than that of normal tissue. Y 90-DOTA-Biotin could be used in 3-step pre-targeting radioimmunotherapy that employs a tumor targeting antibody conjugated with streptavidin, the natural ligand of biotin." + }, + { + "input": "Concept: Strongly disagree (Finding)", + "output": "something described as intensely at odds." + }, + { + "input": "Concept: FAC062-I Have Trouble Concentrating (FACT-BRM Version 4 Questionnaire Question)", + "output": "something described as functional Assessment of Cancer Therapy-Biologic Response Modifiers Version 4 - Additional Concerns-Mental: I have trouble concentrating." + }, + { + "input": "Concept: up-regulation of telomeric recombination at telomere (regulation of DNA recombination at telomere)", + "output": "regulation of DNA recombination at telomere described as any process that activates or increases the frequency, rate or extent of DNA recombination within the telomere." + }, + { + "input": "Concept: ichthyosis-mental retardation-dwarfism-renal impairment syndrome (Disease or Syndrome)", + "output": "Disease or Syndrome described as non-bullous ichthyosis, delayed mental and physical development, nephropathy, and generalized aminoaciduria." + }, + { + "input": "Concept: ADT01TN (Intellectual Product)", + "output": "CDISC Questionnaire Terminology described as alcohol Use Disorder Identification Test: Self-Report Version test name." + }, + { + "input": "Concept: Electrical Conductivity Meters, Dialysate (Medical Device)", + "output": "something described as electric conductivity meters designed to measure and display the electric conductivity of a solution delivered to a dialyzer; the meter may be a component or an accessory of a hemodialysis machine. These devices typically consist of an electronic instrument that can measure within the range of conductivity usually found in dialysate solutions (typically 10 to 20 mS/cm); the instruments include the appropriate sensors, transducers, electronic circuits, and a display for the measurement. Dialysate conductivity meters are commonly used as an integral part of the dialysis system, but some are available as stand-alone units for inspection, maintenance, or calibration of the dialysate circuit of hemodialysis machines." + }, + { + "input": "Concept: Acetylcholine Agents (Pharmaceutical Preparations)", + "output": "Pharmacologic Substance described as drug used for its actions in stimulating cholinergic systems." + }, + { + "input": "Concept: aerobic phenol-containing compound catabolism (aerobic phenol-containing compound metabolic process)", + "output": "aerobic phenol-containing compound metabolic process described as the chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen." + }, + { + "input": "Concept: Undefined Oriental herb and natural substance letter G narrative required (Oriental herbs and natural substances letter G)", + "output": "Oriental herbs and natural substances letter G described as any elsewhere undefined Oriental herb and natural substance, letter G, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com." + }, + { + "input": "Concept: 21q22.1 (Cell Component)", + "output": "something described as a chromosome band present on 21q" + }, + { + "input": "Concept: Have Been a Bit Embarrassed (Intellectual Product)", + "output": "something described as a question about whether an individual has or had embarrassment due to problems with their teeth, denture or mouth." + }, + { + "input": "Concept: dibenzo-p-dioxin degradation (xenobiotic catabolic process)", + "output": "organic cyclic compound catabolic process described as the chemical reactions and pathways resulting in the breakdown of dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds." + }, + { + "input": "Concept: 22q11.22 (Chromosome band)", + "output": "Cell Component described as a chromosome band present on 22q" + }, + { + "input": "Concept: Catecholaminergic Polymorphic Ventricular Tachycardia Gene Mutation Panel Reagents (Medical Device)", + "output": "Medical Device described as molecular assay reagents intended to identify mutations in genes associated with catecholaminergic polymorphic ventricular tachycardia, a ventricular tachycardia characterized by episodic syncope (i.e., fainting) and the absence of structural heart defects. Genetic variants at multiple loci have been associated with catecholaminergic polymorphic ventricular tachycardia. These reagents are intended to detect mutations in multiple catecholaminergic polymorphic ventricular tachycardia-associated loci simultaneously." + }, + { + "input": "Concept: Calcineurin (Intracellular Signaling Peptides and Proteins)", + "output": "Enzymes described as a CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes." + }, + { + "input": "Concept: Neonatal epileptic spasm (Disease or Syndrome)", + "output": "something described as a sudden flexion, extension, or mixed extension-flexion of predominantly proximal and truncal muscles that is usually more sustained than a myoclonic movement but not as sustained as a tonic seizure. Limited forms may occur: grimacing, head nodding, or subtle eye movements. May occur in clusters." + }, + { + "input": "Concept: integrator complex subunit 4 (Gene or Genome)", + "output": "Transcription Regulation Gene described as this gene is involved in the transcription of small nuclear RNAs." + }, + { + "input": "Concept: psivTHERAP.ex ndvdl ea.15min (Rehabilitative treatments and/or training)", + "output": "Therapeutic or Preventive Procedure described as facilitating passive therapeutic exercise for a client to obtain, restore and/or improve his or her normal function of a body part or region that requires rehabilitation. Service is billed in 15-minute increments." + }, + { + "input": "Concept: Oncology (Clinical Class)", + "output": "something described as nurses in this specialty provide care and support for patients diagnosed with cancer" + }, + { + "input": "Concept: Eyeglass Frames (Devices)", + "output": "Ophthalmological Equipment and Supplies described as devices designed to hold lenses in an appropriate position in front of the eyes. Lens types include corrective lenses, such as prescribed by an eye care specialist (ophthalmologist or optometrist) to assist vision (i.e., vision aids), eye protection (e.g., sunglasses), or nonfunctional for aesthetic purposes. Eyeglass frames are usually available in many colors and are made of metal or plastic or a composite material, such as graphite or titanium, with two arms that are supported by the ears; the arms are hinged at the wearer's temples. Usually, the nose pads that line the frames against the wearer's nose are adjustable for fit; in some eyeglass frames, the bridge that spans the top of the nose between the two lenses is also adjustable for fit." + }, + { + "input": "Concept: 4-hydroxycinnamyl alcohol transport (Cell Function)", + "output": "Cell Function described as the directed movement of a p-coumaryl alcohol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." + }, + { + "input": "Concept: cold preservation (Biologic Sample Preservation Procedure)", + "output": "Laboratory Procedures described as preservation of cells, tissues, organs, or embryos by freezing; in histological preparations, cryopreservation or cryofixation is used to maintain the existing form, structure, and chemical composition of all the constituent elements of the specimens." + }, + { + "input": "Concept: Worst Possible Pain (Findings-Based Question)", + "output": "Intellectual Product described as a question about an individual's experience of pain at its worst." + }, + { + "input": "Concept: Basin Stands (Diagnostic, Therapeutic, and Research Equipment)", + "output": "Medical Device described as frames used to hold a basin at an elevated height or to transport basins throughout the hospital. They are typically constructed of metal and are on casters for mobility. Some basin stands are designed specifically for use in magnetic resonance imaging [MRI] environments, i.e., MRI-compatible basin stands, and are made from nonmagnetic materials so that they can be safely used in an MRI suite." + }, + { + "input": "Concept: DEVICE, IRRIGATION, OCULAR SURGERY (Medical Device)", + "output": "Medical Device described as an ocular surgery irrigation device is a device intended to be suspended over the ocular area during ophthalmic surgery to deliver continuous, controlled irrigation to the surgical field." + }, + { + "input": "Concept: Digestive System Neuroendocrine Tumor TNM Finding v8 (Finding)", + "output": "Digestive System Cancer TNM Finding v8 described as a finding about one or more characteristics of a digestive system neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system." + }, + { + "input": "Concept: coronary vein morphogenesis (Organ or Tissue Function)", + "output": "Organ or Tissue Function described as the process in which the anatomical structures of veins of the heart are generated and organized." + }, + { + "input": "Concept: Sentence Structure (Functional Concept)", + "output": "Functional Concept described as specific characteristics of a sentence's construction, including such aspects as its syntax, length, and complexity. Compare SYNTAX." + }, + { + "input": "Concept: EPS8L3 protein, human (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as epidermal growth factor receptor kinase substrate 8-like protein 3 (593 aa, ~67 kDa) is encoded by the human EPS8L3 gene. This protein may be involved in the regulation of son of sevenless homolog 1-mediated guanine exchange activity." + }, + { + "input": "Concept: POLYNORM (Laboratory Procedure)", + "output": "Laboratory Procedure described as the determination of the amount of polychromatophilic normoblasts present in a sample from an experimental organism." + }, + { + "input": "Concept: Syndrome, Waardenburg (hearing impairment)", + "output": "Genetic disorder of skin pigmentation described as rare, autosomal dominant disease with variable penetrance and several known clinical types. Characteristics may include depigmentation of the hair and skin, congenital deafness, heterochromia iridis, medial eyebrow hyperplasia, hypertrophy of the nasal root, and especially dystopia canthorum. The underlying cause may be defective development of the neural crest (neurocristopathy). Waardenburg's syndrome may be closely related to piebaldism. Klein-Waardenburg Syndrome refers to a disorder that also includes upper limb abnormalities." + }, + { + "input": "Concept: Dryers, Gel (Laboratory instruments and equipment)", + "output": "Medical Device described as dryers designed to remove moisture from laboratory gels using heat or heat combined with vacuum. These dryers typically consist of a container with a transparent cover and electric heating elements, a vacuum port, appropriate sheets (e.g., Mylar, polyethylene), and temperature and time controls to establish appropriate drying conditions for different types of gels. Gel dryers are used to dry large gels and/or a combination of smaller gels intended for preservation or for chromatography, electrophoresis, densitometry, and/or other laboratory procedures." + }, + { + "input": "Concept: COWAT1TC (Intellectual Product)", + "output": "Intellectual Product described as controlled Oral Word Association Test test code." + }, + { + "input": "Concept: (Potency Unit)", + "output": "Unit of length described as a unit of length equal to 3 feet, or 36 inches, or 0.9144 meter." + }, + { + "input": "Concept: ADL0202 (Intellectual Product)", + "output": "Intellectual Product described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, Severe Dementia (ADCS-ADL Severe Dementia) Regarding walking (or getting around in a wheelchair) in the past 4 weeks, which best describes subject's optimal performance?" + }, + { + "input": "Concept: vaginal polyp (Mass of abdominal cavity structure)", + "output": "Mass of abdominal cavity structure described as a benign polypoid growth arising from the vaginal wall." + }, + { + "input": "Concept: FACT-L Version 4 - I Have Nausea (FACT-L Version 4 Questionnaire Question)", + "output": "Intellectual Product described as functional Assessment of Cancer Therapy-Lung Version 4 (FACT-L Version 4) Physical Well-Being: I have nausea." + }, + { + "input": "Concept: Health Disparity (Population Group)", + "output": "Population Group described as a population-specific difference in the presence of disease, health outcomes or access to care." + }, + { + "input": "Concept: 4q31.23 (Chromosome band)", + "output": "Chromosome band described as a chromosome band present on 4q" + }, + { + "input": "Concept: molybdenum incorporation via L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide) (Molecular Function)", + "output": "molybdenum incorporation into molybdenum-molybdopterin complex described as the incorporation of molybdenum into a protein via L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide)." + }, + { + "input": "Concept: Parietal abscess of tooth (Oropharyngeal disorders)", + "output": "Abscess of oral tissue described as localized circumscribed purulent area of inflammation in the periodontal tissue. It is a derivative of marginal periodontitis and commonly associated with suprabony and infrabony pockets and interradicular involvements, in contrast to periapical abscess which is attributable to pulp necrosis." + }, + { + "input": "Concept: POWDER AND SOLVENT FOR ORAL SUSPENSION (Combined Dosage Form)", + "output": "something described as powder and solvent intended for the preparation of an oral suspension by dispersing the powder in the solvent." + }, + { + "input": "Concept: Metaplasia, NOS (Signs and Symptoms)", + "output": "something described as a condition in which there is a change of one adult cell type to another similar adult cell type." + }, + { + "input": "Concept: OPHTHALMOLOGY (Specialties, Surgical)", + "output": "Medicine described as a surgical specialty concerned with the structure and function of the eye and the medical and surgical treatment of its defects and diseases." + }, + { + "input": "Concept: Osseointegration (Bone Regeneration)", + "output": "Bone Regeneration described as the growth action of bone tissue as it assimilates surgically implanted devices or prostheses to be used as either replacement parts (e.g., hip) or as anchors (e.g., endosseous dental implants)." + }, + { + "input": "Concept: GNRLOBSC (Intellectual Product)", + "output": "CDISC Define-XML Terminology described as terminology related to the classification of a CDISC domain." + }, + { + "input": "Concept: Calciphylaxes (Rare Non-Neoplastic Disorder)", + "output": "Calcium Metabolism Disorders described as condition of induced systemic hypersensitivity in which tissues respond to appropriate challenging agents with a sudden local calcification." + }, + { + "input": "Concept: Granulation, Dry, Slugging (Laboratory Procedure)", + "output": "Granulation procedure described as mechanically applying pressure by punch and die to form a compact that is subsequently milled and screened resulting in dry granules; excludes blending and conditioning dry powder prior to feeding to the granulation equipment." + }, + { + "input": "Concept: IDSR1-Your Mood to Good/Desired Events (IDS-SR Questionnaire Question)", + "output": "something described as inventory of Depressive Symptomatology Self-Report Version (IDS-SR) Please circle the one response to each item that best describes you for the past seven days: Response of your mood to good or desired events." + }, + { + "input": "Concept: Hilar/Perihilar Bile Duct (Anatomy Qualifier)", + "output": "Anatomy Qualifier described as these include the bile ducts which are located at the hilum of the liver as well as the segment where the left and right hepatic ducts join just outside the liver to form the common bile duct." + }, + { + "input": "Concept: glycerophospholipid flippase activity (flippase activity)", + "output": "flippase activity described as catalysis of the movement of a glycerophospholipid from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP." + }, + { + "input": "Concept: VFQ2-Difficulty Taking Part in Sports (VFQ25-Self Administered Format Questionnaire Question)", + "output": "Intellectual Product described as national Eye Institute Visual Functioning Questionnaire - 25 Version 2000 Self-Administered Format - Distance Vision: Because of your eyesight, how much difficulty do you have taking part in active sports or other outdoor activities that you enjoy (like golf, bowling, jogging, or walking)?" + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Immunology, Tissue Typing, Human Leukocyte Antigen, Class II, DP Loci (IVD Test Reagent/Kits, Molecular Assay, Immunology, Tissue Typing, Human Leukocyte Antigen, Class II)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Immunology, Tissue Typing, Human Leukocyte Antigen, Class II described as molecular assay reagents used in immunological tests to determine one or more of the alleles of the cell-surface proteins (alleles) coded in the locus DP of the class II genes of the major histocompatibility complex. These tests are mostly used to match donor and recipient tissues before transplants (e.g., kidney, medulla)." + }, + { + "input": "Concept: extrachromosomal DNA location (cellular anatomical entity)", + "output": "cellular anatomical entity described as DNA structures that are not part of a chromosome." + }, + { + "input": "Concept: Cocaine, Crack (Organic Chemical)", + "output": "Illicit Drugs described as an illegal drug composed of the smokable, baseform of cocaine that is produced by dissolving cocaine hydrochloride in an alkali solution, usually sodium bicarbonate and water, and subsequent boiling. Cocaine causes euphoria, loss of appetite, insomnia, and is highly addictive." + }, + { + "input": "Concept: transcription factor TFIIIB-alpha complex location (Cell Component)", + "output": "something described as a transcription factor TFIIIB-beta complex that contains the TATA-binding protein (TBP), B'' and a specialized homolog of the conserved subunit BRF referred to as BRFU or TFIIIB50, which found in human but not conserved in yeast; the complex is involved in the regulation of transcription from type 3 (upstream) RNA polymerase III promoters." + }, + { + "input": "Concept: Poor head control (Central Nervous System)", + "output": "MUSCLE SOFT, TISSUE described as difficulty to maintain correct position of the head while standing or sitting." + }, + { + "input": "Concept: Angiology (Medical Specialities)", + "output": "something described as the study, diagnosis, and treatment of diseases of the blood vessels (VASCULAR DISEASES) and vessels of lymphatic system (LYMPHATIC DISEASES)." + }, + { + "input": "Concept: QLES1-Felt Good Doing Course Work (Intellectual Product)", + "output": "something described as quality Of Life Enjoyment And Satisfaction Questionnaire (Q-LES-Q) During the past week how much of the time have you: felt good while doing your course/class work?" + }, + { + "input": "Concept: Antibacterials (Substance categorized by disposition)", + "output": "Microbicides described as a family of substances capable of destroying or inhibiting the growth of bacteria." + }, + { + "input": "Concept: N-Glycosylation Site (Post-Translational Modification Site)", + "output": "something described as a glycosylation site is an amino acid residue within a peptide that accepts oligosaccharide via amide linkage, specifically through amide nitrogen of asparagine via N-acetylglucosamine, as one of the post-translational modifications." + }, + { + "input": "Concept: hepatitis chronic persistent (Inflammatory disorders following infection)", + "output": "Hepatocellular damage and hepatitis NEC described as a mild form of chronic hepatitis causing limited damage to the liver." + }, + { + "input": "Concept: regulation of imaginal disc growth (regulation of organ growth)", + "output": "regulation of organ growth described as any process that modulates the frequency, rate or extent of the growth of the imaginal disc." + }, + { + "input": "Concept: embryo/fetus chemotherapy (Therapeutic or Preventive Procedure)", + "output": "embryo/fetus therapy described as application of the beneficial effects of drugs to control or cure diseases or abnormal states in an embryo or a fetus." + }, + { + "input": "Concept: Metatarsal region (Bone structure of foot)", + "output": "Metatarsal bone structure described as a bone belonging to the middle part of the foot located between toes and ankle. There are 5 metatarsal bones and they are numbered from the medial side." + }, + { + "input": "Concept: Salvia sclarea L. (Oils, Volatile)", + "output": "Oils, Volatile described as clary sage." + }, + { + "input": "Concept: chlorosome (intracellular non-membrane-bounded organelle)", + "output": "something described as a large enclosure of aggregated pigment, typically bacteriochlorophyll c (BChl c), that acts as a light-harvesting antenna structure and is characteristic of green photosynthetic bacteria (e.g. Chlorobiaceae). The BChl aggregates are organized into lamellar elements by pigment-pigment rather than pigment-protein interactions. Chlorosomes also contain BChl a, carotenoids, quinones, lipids, and proteins, and are attached to the cytoplasmic membrane via a BChl a-containing protein baseplate." + }, + { + "input": "Concept: positive regulation of blood vessel size (Thesaurus of Psychological Index Terms)", + "output": "Peripheral blood flow - finding described as state of increased caliber of the blood vessels." + }, + { + "input": "Concept: Trichomonas vaginalis Measurement (Laboratory Procedure)", + "output": "Microbiology procedure described as a measurement of the Trichomonas vaginalis in a biological specimen." + }, + { + "input": "Concept: beta-L-dioxolane-cytidine (pyrimidine analog)", + "output": "Pharmacologic Substance described as a drug being studied for use as an anticancer agent." + }, + { + "input": "Concept: bupivacaine hcl (Anesthetics)", + "output": "Pharmacologic Substance described as a drug used to relieve pain by blocking signals at nerve endings. It is being studied in the relief of pain following surgery for cancer. It is a type of local anesthetic." + }, + { + "input": "Concept: StudyOverallStatus.studyStoppedReasonCode (Intellectual Product)", + "output": "Study Stopped Reason Code described as a coded value specifying why the study has been halted or terminated (for suspended, terminated or withdrawn studies)." + }, + { + "input": "Concept: Disease, Fong (Hereditary Connective Tissue Disorder)", + "output": "Nail and nail bed conditions described as a rare autosomal dominant syndrome caused by mutations in the LMX1B gene, which is characterized by dysplastic nails, absence or hypoplasia of the patellae, iliac horns, deformities of the radial heads, and nephropathy." + }, + { + "input": "Concept: HHG-3 (DHH gene)", + "output": "DHH gene described as human DHH wild-type allele is located in the vicinity of 12q13.12 and is approximately 5 kb in length. This allele, which encodes desert hedgehog protein, is involved in the regulation of both male gonadal differentiation and perineurial development. Mutations in this gene are associated with both 46XY partial gonadal dysgenesis, with minifascicular neuropathy, and 46XY sex reversal 7." + }, + { + "input": "Concept: CR-Complete Response (Finding)", + "output": "Disease remission described as the disappearance of all signs of cancer in response to treatment. This does not always mean the cancer has been cured." + }, + { + "input": "Concept: cecal (Colon structure)", + "output": "Lower Gastrointestinal Tract described as a blind pouch-like commencement of the colon in the right lower quadrant of the abdomen at the end of the small intestine and the start of the large intestine." + }, + { + "input": "Concept: Panic Self-Control (Self-control as a personality trait)", + "output": "Finding described as personal actions to eliminate or reduce sudden, intense feelings of apprehension, fright, terror, or nervousness" + }, + { + "input": "Concept: CSS0705B (Intellectual Product)", + "output": "C-SSRS Children's Baseline/Screening Questionnaire Question described as columbia-Suicide Severity Rating Scale Children's Baseline/Screening - Have you ever decided how or when you would make yourself not alive anymore/kill yourself? Have you ever planned out (worked out the details of) how you would do it? What was your plan? When you made this plan (or worked out these details), was any part of you thinking about actually doing it? (Past 6 Months)." + }, + { + "input": "Concept: lurbinectedin (Pharmacologic Substance)", + "output": "L [Preparations] described as a synthetic tetrahydropyrrolo [4, 3, 2-de]quinolin-8(1H)-one alkaloid analogue with potential antineoplastic activity. Lurbinectedin covalently binds to residues lying in the minor groove of DNA, which may result in delayed progression through S phase, cell cycle arrest in the G2/M phase and cell death. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C82382\" active clinical trials using this agent." + }, + { + "input": "Concept: LPPG:FO 2-phospho-L-lactate transferase activity (phosphotransferase activity, alcohol group as acceptor)", + "output": "phosphotransferase activity, alcohol group as acceptor described as catalysis of the reaction: 7,8-didemethyl-8-hydroxy-5-deazariboflavin + lactyl-2-diphospho-5'-guanosine = coenzyme F420-0 + GMP." + }, + { + "input": "Concept: NRTI (Reverse Transcriptase Inhibitors)", + "output": "something described as a substance with a structure similar to a nucleoside molecule that is capable of occupying the active catalytic site of a reverse transcriptase resulting in inhibition of enzyme function, chain termination, and inhibition of viral replication. These compounds are converted to their active phosphorylated forms by cellular kinases." + }, + { + "input": "Concept: Caveolin 2 (Biologically Active Substance)", + "output": "Structural protein described as caveolin-2 (162 aa, ~18 kDa) is encoded by the human CAV2 gene. This protein plays a role in caveolae formation and function." + }, + { + "input": "Concept: Orbivirus, NOS (Sedoreovirinae)", + "output": "Sedoreovirinae described as any viral organism that can be assigned to the genus Orbivirus." + }, + { + "input": "Concept: Oropharyngeal Cancer pT3 TNM Finding v7 (Oropharyngeal Cancer Pathologic Primary Tumor TNM Finding v7)", + "output": "something described as oropharyngeal cancer with tumor size more than 4 centimeters in greatest dimension or extension to lingual surface of epiglottis." + }, + { + "input": "Concept: IgE immunoglobulin complex location, circulating (Cell Component)", + "output": "Immunoglobulin complex location, circulating described as a protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." + }, + { + "input": "Concept: Lacrimal gland aplasia (Aplastic/hypoplastic lacrimal glands)", + "output": "Aplastic/hypoplastic lacrimal glands described as a congenital defect of development characterized by absence of the lacrimal gland." + }, + { + "input": "Concept: snare (Membrane Fusion Proteins)", + "output": "Vesicular Transport Proteins described as a superfamily of small proteins which are involved in the MEMBRANE FUSION events, intracellular protein trafficking and secretory processes. They share a homologous SNARE motif. The SNARE proteins are divided into subfamilies: QA-SNARES; QB-SNARES; QC-SNARES; and R-SNARES. The formation of a SNARE complex (composed of one each of the four different types SNARE domains (Qa, Qb, Qc, and R)) mediates MEMBRANE FUSION. Following membrane fusion SNARE complexes are dissociated by the NSFs (N-ETHYLMALEIMIDE-SENSITIVE FACTORS), in conjunction with SOLUBLE NSF ATTACHMENT PROTEIN, i.e., SNAPs" + }, + { + "input": "Concept: Ad5-survivin-transduced Autologous DC Vaccine (therapeutic autologous dendritic cells)", + "output": "Immunologic Factor described as a cell-based cancer vaccine containing autologous dendritic cells (DCs) that are transduced with a replication-deficient adenovirus type 5 vector (Ad5) encoding a mutated form of the tumor-associated antigen (TAA) survivin, with potential immunostimulatory and antineoplastic activities. Upon administration, Ad5-survivin-transduced autologous DC vaccine may elicit an immune response against cancer cells expressing survivin by activating cytotoxic T-cells (CTLs). This leads to an induction of cell death in survivin-positive tumor cells. Survivin, a member of the inhibitor of apoptosis (IAP) family of proteins, may be upregulated in certain tumor cell types and plays a key role in tumor cell growth and survival." + }, + { + "input": "Concept: Webcasts as Topics (videoconferencing communications)", + "output": "something described as works about transmission of live or pre-recorded audio or video content via connection or download from the INTERNET." + }, + { + "input": "Concept: Protocol Specialist (Study Personnel)", + "output": "Professional or Occupational Group described as a staff member assigned primary responsibility for fulfilling core responsibilities for a specific study. Manages the protocol development and review process, working closely with the Protocol Chair and the study team to develop the protocol and prepare responses. Coordinates the protocol development and study implementation teams throughout study development and conduct." + }, + { + "input": "Concept: Missing Diagnosis (Finding)", + "output": "Finding described as failure to identify or diagnose a medical condition at the time a health professional is acquainted with the symptoms." + }, + { + "input": "Concept: Ehlers-Danlos Disease (Skin Diseases, Genetic)", + "output": "Syndrome described as a group of inherited connective tissue disorders characterized by loose and fragile skin and joint hypermobility." + }, + { + "input": "Concept: Musculoskeletal Chest Pain due to Bornholm Disease (Musculoskeletal Chest Pain due to Myositis)", + "output": "something described as a condition in which there is myositis secondary to an infectious etiology." + }, + { + "input": "Concept: Pancreas part (Pancreas)", + "output": "something described as any component of the organ behind the lower part of the stomach that is fish-shaped and is a compound gland composed of both exocrine and endocrine tissues that make and secrete insulin and enzymes that help the body digest food." + }, + { + "input": "Concept: PEPTOSTREPTOCOCCUS STOMATIS (Bacterium)", + "output": "Peptostreptococcus described as any bacterial organism that can be assigned to the species Peptostreptococcus stomatis." + }, + { + "input": "Concept: Breast Carcinoma-Amplified Sequence 3 (Tumor-Related Protein)", + "output": "Amino Acid, Peptide, or Protein described as breast carcinoma-amplified sequence 3 (928 aa, ~101 kDa) is encoded by the human BCAS3 gene. This protein may play a role in both estrogen response and breast cancer." + }, + { + "input": "Concept: undef.aqpnct anes.narr req' (Therapeutic or Preventive Procedure)", + "output": "Therapeutic or Preventive Procedure described as any elsewhere undefined acupuncture anesthesia, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com." + }, + { + "input": "Concept: Pleural Malignant Mesothelioma Clinical TNM Finding v8 (Finding)", + "output": "something described as a clinical finding about one or more characteristics of pleural malignant mesothelioma, following the rules of the TNM AJCC v8 classification system." + }, + { + "input": "Concept: Lymphotoxin beta (Tumor Necrosis Factors)", + "output": "something described as a membrane-bound tumor necrosis family member found primarily on LYMPHOCYTES. It can form a heterotrimer (LYMPHOTOXIN ALPHA1, BETA2 HETEROTRIMER) with the soluble ligand LYMPHOTOXIN-ALPHA and anchor it to the cell surface. The membrane-bound complex is specific for the LYMPHOTOXIN BETA receptor." + }, + { + "input": "Concept: Nurturance (Personality Traits)", + "output": "Social Behavior described as need, tendency, or process of providing care and support to others. For animal populations, use ANIMAL MATERNAL BEHAVIOR or ANIMAL PARENTAL BEHAVIOR." + }, + { + "input": "Concept: NXPE Family Member 1 (Regulatory Protein)", + "output": "Biologically Active Substance described as NXPE family member 1 (547 aa, ~63 kDa) is encoded by the human NXPE1 gene. This protein may play a role in the metabolism of lipids." + }, + { + "input": "Concept: Global Alignment of Immunization safety Assessment in pregnancy Insufficient Evidence for Diagnosis of Preeclampsia (Intellectual Product)", + "output": "something described as GAIA Insufficient Evidence for Diagnosis of Preeclampsia is defined as a pregnancy with gestational age greater than or equal to 20 weeks and either a) The inability to measure blood pressure OR b) The inability to evaluate for proteinuria." + }, + { + "input": "Concept: Increased level of myristic acid in serum (Finding)", + "output": "Abnormal circulating monocarboxylic acid cocentration described as an increase in the level of myristic acid in the serum." + }, + { + "input": "Concept: Trial Supply Storage Subcategory (Document type)", + "output": "Intellectual Product described as subcategory name for the eTMF domain containing documents detailing the storage of investigational product (IP) and supplies." + }, + { + "input": "Concept: melanoma differentiation-associated gene 5 (Gene or Genome)", + "output": "Helicase Gene described as this gene is involved in binding to viral ribonucleic acids." + }, + { + "input": "Concept: IMMUNOPRECIPITATION (Chemical Precipitation)", + "output": "Immunologic Tests described as antigen aggregation with antibody, in the right ratios, to cause precipitation." + }, + { + "input": "Concept: Insufficient Milk Syndrome (Syndrome)", + "output": "something described as failure to thrive due to poor intake by the infant, inadequate feeding schedule or insufficient maternal production of breast milk." + }, + { + "input": "Concept: Solving simple problems (Problem Solving)", + "output": "Problem Solving described as finding solutions to a simple problem involving a single issue or question, by identifying and analysing the issue, developing solutions, evaluating the potential effects of the solutions and executing a chosen solution." + }, + { + "input": "Concept: integral component of presynaptic endocytic zone membrane (intrinsic component of presynaptic endocytic zone membrane)", + "output": "something described as the component of the presynaptic endocytic zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." + }, + { + "input": "Concept: UHDRS 1999 Version - Irritable Behavior: Frequency (Intellectual Product)", + "output": "Intellectual Product described as unified Huntington's Disease Rating Scale 1999 Version (UHDRS 1999 Version) Irritable behavior: Frequency: In the past month, how often have you felt impatient, irritable, or \"cranky\"?" + }, + { + "input": "Concept: KPPS2 (Gene or Genome)", + "output": "something described as human DSP wild-type allele is located in the vicinity of 6p24 and is approximately 45 kb in length. This allele, which encodes desmoplakin protein, plays a role in the regulation of protein-protein interactions in desmosome junctions. Mutations in the gene are associated with several keratodermas and cardiomyopathies." + }, + { + "input": "Concept: Geometric Mean Fluorescence Intensity Unit (Quantitative Concept)", + "output": "Mean Fluorescence Intensity Unit described as a unit of measure for the geometric mean fluorescence intensity." + }, + { + "input": "Concept: Interlobar (Anatomy Qualifier)", + "output": "Anatomy Qualifier described as between lobes." + }, + { + "input": "Concept: Illnesses, Catastrophic (Disease Attributes)", + "output": "Disease Attributes described as an acute or prolonged illness usually considered to be life-threatening or with the threat of serious residual disability. Treatment may be radical and is frequently costly." + }, + { + "input": "Concept: FTHS (Gene or Genome)", + "output": "something described as human SH3PXD2B wild-type allele is located in the vicinity of 5q35.1 and is approximately 129 kb in length. This allele, which encodes SH3 and PX domain-containing protein 2B, plays a role in podosome assembly. Mutation of the gene is associated with Frank-Ter Haar syndrome." + }, + { + "input": "Concept: positive regulation of semaphorin-plexin signalling pathway involved in outflow tract morphogenesis (positive regulation of animal organ morphogenesis)", + "output": "Organ or Tissue Function described as any process that activates or increases the frequency, rate or extent of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis." + }, + { + "input": "Concept: Ann Arbor Stage III Follicular Lymphoma (Neoplastic Process)", + "output": "Follicular Lymphoma by Ann Arbor Stage described as ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S)." + }, + { + "input": "Concept: x inactivation (Gene Expression Regulation)", + "output": "Gene Expression Regulation described as a dosage compensation process occurring at an early embryonic stage in mammalian development whereby, at random, one X CHROMOSOME of the pair is repressed in the somatic cells of females." + }, + { + "input": "Concept: colistin sodium methanesulfonate (colistimethate)", + "output": "Allergen class described as the sodium salt of colistimethate, a broad-spectrum polymyxin antibiotic against most aerobic Gram-negative bacteria except Proteus bacteria. Colistimethate sodium contains the pentasodium salt of the penta(methanesulfonic acid) derivative of colistin A as the major component and a small proportion of the petasodium salt of the pentamethanesulfonate derivative of colistin B. Colistins are cyclic polypeptides produced from Bacillus colistinus or B. polymyxa and function as a surfactant which penetrates into and disrupts the bacterial cell membrane, thereby resulting in bactericidal effect." + }, + { + "input": "Concept: Crowdsourcings (Research Activity)", + "output": "Data Collection described as social media model for enabling public involvement and recruitment in participation. Use of social media to collect feedback and recruit volunteer subjects." + }, + { + "input": "Concept: pleconaril (Antiviral Agents)", + "output": "Other antivirals in ATC described as a small-molecule inhibitor with activity against viruses in the picornaviridae family, including enterovirus and rhinovirus. Pleconaril binds to a hydrophobic pocket in the major capsid protein and prevents uncoating of the viral RNA genome. In enteroviruses it also prevents the virus from attaching itself to the host cell." + }, + { + "input": "Concept: tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase (methylthiotransferase activity)", + "output": "catalytic activity, acting on a tRNA described as catalysis of the reaction: N(6)-L-threonylcarbamoyladenine(37) in tRNA + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = 2-methylthio-N(6)-L-threonylcarbamoyladenine(37) in tRNA + S-adenosyl-L-homocysteine + (sulfur carrier) + L-methionine + 5'-deoxyadenosine." + }, + { + "input": "Concept: regulation of artery smooth muscle contraction (Organ or Tissue Function)", + "output": "regulation of vascular smooth muscle contraction described as any process that modulates the frequency, rate or extent of artery smooth muscle contraction." + }, + { + "input": "Concept: CAPSULE, SOFTGEL, EXTENDED RELEASE (Biomedical or Dental Material)", + "output": "something described as a capsule, covered with a soft gelatin shell and containing a liquid, suspension, or semisolid, that is designed to release active and/or inert ingredient(s) at a controlled, prolonged rate to reduce dosing frequency." + }, + { + "input": "Concept: Decision Making (Applying knowledge)", + "output": "Mental Process described as the process of making a selective intellectual judgment when presented with several complex alternatives consisting of several variables, and usually defining a course of action or an idea." + }, + { + "input": "Concept: mexicans (Hispanics)", + "output": "Hispanics described as denotes a person from or of Mexico." + }, + { + "input": "Concept: Index Lesion (Lesion)", + "output": "Lesion described as the largest tumor lesion targeted by therapy." + }, + { + "input": "Concept: HAMD316 (HAMD 24 Clinical Classification Question)", + "output": "HAMD 24 Clinical Classification Question described as hamilton Depression Rating Scale 24 Item - Insight." + }, + { + "input": "Concept: fructose 1-monophosphate aldolase activity (aldehyde-lyase activity)", + "output": "aldehyde-lyase activity described as catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate." + }, + { + "input": "Concept: Dental Implants, Endosteal (Jaw implant)", + "output": "Implantable dental prosthesis, device described as an endosseous implant is a device made of a material such as titanium intended to be surgically placed in the bone of the upper or lower jaw arches to provide support for prosthetic devices, such as artificial teeth, and to restore the patient's chewing function." + }, + { + "input": "Concept: Genomic Molecule Entity (Functional Concept)", + "output": "Functional Concept described as the sequences, mRNA transcripts, protein products, or other genome encoded molecules of the cell." + }, + { + "input": "Concept: 16: 31178812-31251691 (Spatial Concept)", + "output": "Spatial Concept described as physical location of ITGAM_Gene" + }, + { + "input": "Concept: Pancreatitis, CTCAE 5 (Finding)", + "output": "Gastrointestinal Disorders, CTCAE described as a disorder characterized by inflammation of the pancreas with no documented pancreas infection." + }, + { + "input": "Concept: pg/day (Unit of Dose Calculation)", + "output": "Unit of Dose Calculation described as picograms per day." + }, + { + "input": "Concept: Advanced Bladder Carcinoma (Advanced Genitourinary System Carcinoma)", + "output": "Advanced Genitourinary System Carcinoma described as a bladder carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment." + }, + { + "input": "Concept: UPD2-Apathy (Intellectual Product)", + "output": "MDS-UPDRS Questionnaire Question described as the Movement Disorder Society version of the Unified Parkinson's Disease Rating Scale - Over the past week, have you felt indifferent to doing activities or being with people?" + }, + { + "input": "Concept: VASTUS LATERALIS MUSCLE (Body Part, Organ, or Organ Component)", + "output": "Muscle described as a muscle in the quadriceps femoris muscle group lateral to the vastus intermedius; primary function is the extension of the femorotibial joint." + }, + { + "input": "Concept: Formyltetrahydrofolates (Tetrahydrofolates)", + "output": "Tetrahydrofolates described as tetrahydrofolates which are substituted by a formyl group at either the nitrogen atom in the 5 position or the nitrogen atom in the 10 position. N(5)-Formyltetrahydrofolate is leucovorin (citrovorum factor) while N(10)-formyltetrahydrofolate is an active coenzyme which functions as a carrier of the formyl group in a number of enzymatic reactions." + }, + { + "input": "Concept: nucleotide analogue GS 9219 (Purine antagonist)", + "output": "Purine antagonist described as a prodrug of the acyclic nucleoside phosphonate analogue 9-(2-phosphonylmethoxyethyl)guanine (PMEG) with potential antineoplastic activity. Formulated to selectively accumulate in lymphocytes, nucleotide analogue GS 9219 is converted to its active metabolite, PMEG diphosphate (PMEGpp), via enzymatic hydrolysis, deamination, and phosphorylation; subsequently, PMEGpp is incorporated into nascent DNA chains by DNA polymerases, which may result in the termination of DNA synthesis, S-phase cell cycle arrest, and the induction of apoptosis in susceptible lymphoma cell populations." + }, + { + "input": "Concept: TSCC0109 (Intellectual Product)", + "output": "Intellectual Product described as trauma Symptom Checklist for Children (TSCC) Feeling sad or unhappy." + }, + { + "input": "Concept: Project (Conceptual Entity)", + "output": "something described as any specifically defined piece of work that is undertaken or attempted to meet a single requirement." + }, + { + "input": "Concept: Control, Rodent (Control of vectors)", + "output": "something described as the reduction or regulation of the population of noxious, destructive, or dangerous rodents through chemical, biological, or other means." + }, + { + "input": "Concept: Shortness of Breath at its Worst (Findings-Based Question)", + "output": "Intellectual Product described as a question about an individual's shortness of breath at its worst." + }, + { + "input": "Concept: Proto-Oncogene c-ErbB-1 H773 V774insPH (EGFR Protein Variant)", + "output": "something described as an insertion of the amino acid sequence proline-histidine between the histidine at position 773 and the valine at position 774 of the epidermal growth factor receptor protein." + }, + { + "input": "Concept: -3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity (Molecular Function)", + "output": "hydrolase activity, hydrolyzing O-glycosyl compounds described as catalysis of the reaction: H2O + an N-acetyl-alpha-D-glucosaminyl-[glycoprotein] <=> N-acetyl-alpha-D-glucosaminide + a [glycoprotein]-(L-serine/L-threonine)." + }, + { + "input": "Concept: regulation of mRNA metabolism (Genetic Function)", + "output": "something described as any process that modulates the frequency, rate or extent of mRNA metabolic process." + }, + { + "input": "Concept: Anti-CD38/Anti-CD3 Bispecific Monoclonal Antibody GBR 1342 (Anti-CD38 Monoclonal Antibody)", + "output": "Anti-CD38 Monoclonal Antibody described as a humanized, bispecific monoclonal antibody (BsAb) against human CD3, a T-cell surface antigen, and the human cell surface glycoprotein CD38, a tumor-associated antigen (TAA), with potential antineoplastic activity. Upon administration, anti-CD38/anti-CD3 bispecific monoclonal antibody GBR 1342 binds to both CD3 on T-cells and CD38 expressed on certain tumor cells. This results in the cross-linking of T-cells and tumor cells, and induces a potent cytotoxic T-lymphocyte (CTL) response against CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies; its expression has been correlated with poor prognosis. GBR 1342 uses the proprietary bispecific engagement by antibodies based on the T-cell receptor (BEAT) platform." + }, + { + "input": "Concept: SYSTEM, DIALYSATE DELIVERY, SINGLE PATIENT (Dialysate Delivery Systems)", + "output": "Medical Device described as a hemodialysis system and accessories is a device that is used as an artificial kidney system for the treatment of patients with renal failure or toxemic conditions and that consists of an extracorporeal blood system, a conventional dialyzer, a dialysate delivery system, and accessories. Blood from a patient flows through the tubing of the extracorporeal blood system and accessories to the blood compartment of the dialyzer, then returns through further tubing of the extracorporeal blood system to the patient. The dialyzer has two compartments that are separated by a semipermeable membrane. While the blood is in the blood compartment, undesirable substances in the blood pass through the semipermeable membrane into the dialysate in the dialysate compartment. The dialysate delivery system controls and monitors the dialysate circulating through the dialysate compartment of the dialyzer. (1) The extracorporeal blood system and accessories consists of tubing, pumps, pressure monitors, air foam or bubble detectors, and alarms to keep blood moving safely from the blood access device and accessories for hemodialysis (Sec. 876.5540) to the blood compartment of the dialyzer and back to the patient. (2) The conventional dialyzer allows a transfer of water and solutes between the blood and the dialysate through the semipermeable membrane. The semipermeable membrane of the conventional dialyzer has a sufficiently low permeability to water that an ultrafiltration controller is not required to prevent excessive loss of water from the patient's blood. This conventional dialyzer does not include hemodialyzers with the disposable inserts (Kiil type) (Sec. 876.5830) or dialyzers of high permeability (Sec. 876.5860). (3) The dialysate delivery system consists of mechanisms that monitor and control the temperature, conductivity, flow rate, and pressure of the dialysate and circulates dialysate through the dialysate compartment of the dialyzer. The dialysate delivery system includes the dialysate concentrate for hemodialysis (liquid or powder) and alarms to indicate abnormal dialysate conditions. This dialysate delivery system does not include the sorbent regenerated dialysate delivery system for hemodialysis (Sec. 876.5600), the dialysate delivery system of the peritoneal dialysis system and accessories (Sec. 876.5630), or the controlled dialysate delivery system of the high permeability hemodialysis system (Sec. 876.5860). (4) Remote accessories to the hemodialysis system include the unpowered dialysis chair without a scale, the powered dialysis chair without a scale, the dialyzer holder set, dialysis tie gun and ties, and hemodialysis start/stop tray." + }, + { + "input": "Concept: Retinoic Acids (Organic Chemical)", + "output": "Drug allergens described as a nutrient that the body needs in small amounts to function and stay healthy. Retinoic acid is made in the body from vitamin A and helps cells to grow and develop, especially in the embryo. A form of retinoic acid made in the laboratory is put on the skin to treat conditions such as acne and is taken by mouth to treat acute promyelocytic leukemia (a fast-growing cancer in which there are too many immature blood-forming cells in the blood and bone marrow). Retinoic acid is being studied in the prevention and treatment of other types of cancer." + }, + { + "input": "Concept: PSV2 (Cancer Vaccines)", + "output": "Pharmacologic Substance described as a personalized cancer vaccine comprised of a not yet disclosed oncolytic virus encoding tumor-specific neoantigens that have been identified through genetic sequencing of a patient's tumor cells, with potential immunostimulatory and antineoplastic activities. Upon administration, the neoantigen-encoding personalized virus-2 (PSV-2) infects cells and expresses the tumor-specific neoantigens (TSNAs). This stimulates the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing the TSNAs, leading to tumor cell lysis." + }, + { + "input": "Concept: QA Report (Thesaurus of Psychological Index Terms)", + "output": "Technology described as a system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required." + }, + { + "input": "Concept: Robinow-like syndrome (Congenital anomaly of anterior chamber of eye)", + "output": "Hereditary Connective Tissue Disorder described as the association of the clinical features present in Robinow syndrome (short stature, mesomelic brachymelia, macrocephaly and hypoplastic genitalia) with anterior chamber cleavage anomalies. It has been described in two sisters and is transmitted as an autosomal recessive trait." + }, + { + "input": "Concept: Grade 2 Glaucoma (Glaucoma, CTCAE)", + "output": "something described as EIOP which can be reduced to 21 mmHg or under with topical medications and no visual field deficit" + }, + { + "input": "Concept: post-embryonic hindgut morphogenesis (post-embryonic animal morphogenesis)", + "output": "Organ or Tissue Function described as the process in which the anatomical structures of the hindgut are generated and organized, during the post-embryonic phase." + }, + { + "input": "Concept: Giant Urticarias (Urticaria)", + "output": "Laryngeal spasm, oedema and obstruction described as rapid swelling (edema) of the dermis, subcutaneous tissue, mucosa and submucosal tissues of the skin of the face, normally around the mouth, and the mucosa of the mouth and/or throat, as well as the tongue during a period of minutes to several hours. The swelling can also occur elsewhere, typically in the hands. Angioedema is similar to urticaria, but the swelling is subcutaneous rather than on the epidermis." + }, + { + "input": "Concept: Absent epiphysis of the proximal phalanx of the 4th finger (Absent epiphyses of the proximal phalanges of the hand)", + "output": "Absent epiphyses of the proximal phalanges of the hand described as absence of the epiphysis located at the proximal end of the proximal phalanx of the 4th finger." + }, + { + "input": "Concept: Syncope, Situational (Syncope)", + "output": "Vasovagal syncope described as a condition in which neurally mediated syncope occurs due to a specific circumstance, such as micturition, defecation, coughing, or traction of the hair." + }, + { + "input": "Concept: Platelet Syndromes, Grey (Disease or Syndrome)", + "output": "Platelet Storage Pool Deficiency described as a rare, inherited platelet disorder characterized by a selective deficiency in the number and contents of platelet alpha-granules. It is associated with THROMBOCYTOPENIA, enlarged platelets, and prolonged bleeding time." + }, + { + "input": "Concept: Physiologic motion barrier (Finding)", + "output": "Finding described as the limit of active motion." + }, + { + "input": "Concept: Sexual Selection, Animal (Sexual Behavior, Animal)", + "output": "Sexual Behavior, Animal described as the selection or choice of sexual partner in animals. Often this reproductive preference is based on traits in the potential mate, such as coloration, size, or behavioral boldness. If the chosen ones are genetically different from the rejected ones, then NATURAL SELECTION is occurring." + }, + { + "input": "Concept: food; intoxication (Gastroenteritis)", + "output": "Gastroenteritis described as any disorder that results from the consumption of food contaminated with an infectious agent or toxin." + }, + { + "input": "Concept: Abnormal speech prosody (Finding)", + "output": "something described as an anomaly of the expressive patterns of speech that involve intonation, stress pattern, loudness variations, pausing, articulatory force, and rhythm. []" + }, + { + "input": "Concept: Bayesian statistics (Quantitative Concept)", + "output": "Statistical Technique described as statistical approach named for Thomas Bayes (1701-1761) that has among its features giving a subjective interpretation to probability, accepting the idea that it is possible to talk about the probability of hypotheses being true and of parameters having particular values." + }, + { + "input": "Concept: histone H3K36 acetylation (histone H3 acetylation)", + "output": "Molecular Function described as the modification of histone H3 by the addition of an acetyl group to a lysine residue at position 36 of the histone." + }, + { + "input": "Concept: ALAS1 Gene (Gene or Genome)", + "output": "something described as this gene plays a role in both lipid metabolism and heme biosynthesis." + }, + { + "input": "Concept: Resectable Liposarcoma (Neoplastic Process)", + "output": "Neoplastic Process described as liposarcoma that is amenable to surgical resection." + }, + { + "input": "Concept: riboflavin synthase complex location (Cell Component)", + "output": "something described as an flavoprotein that catalyzes the reaction the breakdown of dimethyl(ribityl)lumazine to form riboflavin and ribitylamino-amino-dihydroxypyrimidine." + }, + { + "input": "Concept: negative regulation of lateral pseudopodium assembly (negative regulation of pseudopodium assembly)", + "output": "Cell Function described as any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell." + }, + { + "input": "Concept: ALX0171 (Monoclonal Antibodies)", + "output": "Antiviral Agents described as a trivalent nanobody composed of three monovalent Nb017 moieties linked with glycine-serine (GS) linkers, directed against the fusion protein (F protein) of human respiratory syncytial virus (RSV), with potential activity against RSV infections. Upon administration via nebulization and inhalation, the anti-RSV nanobody ALX-0171 targets and binds to RSV F protein, neutralizing the virus, and preventing viral entry into host cells. RSV F protein is a small envelope glycoprotein required for cytopathic syncytia formation that results from cell-to-cell fusion." + }, + { + "input": "Concept: Photodynamic therapy (Medicine Services and Procedures)", + "output": "neoplasm/cancer radiation therapy described as intravenous administration of a photosensitizing agent which selectively concentrates in cancer cells, followed by exposure of the tumor to laser light of a specific wavelength; the resulting cytotoxic free radicals destroy the tumor." + }, + { + "input": "Concept: gamma-linolenate elongase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the reaction: malonyl-CoA + gamma-linolenoyl-CoA + H+ = (8Z,11Z,14Z)-3-oxoicosa-8,11,14-trienoyl-CoA + coenzyme A + carbon dioxide." + }, + { + "input": "Concept: FRAXF syndrome (Fragile X chromosome)", + "output": "Disease or Syndrome described as FRAXF syndrome was originally identified in a family with developmental delay and an expanded CCG repeat at the folate-sensitive FRAXF fragile site. Since this initial description, FRAXF has been associated with a range of manifestations but no clear phenotype has been established. Prevalence is unknown. The FRAXF fragile site is located at Xq28 within the 5'UTR of the TMEM185A gene." + }, + { + "input": "Concept: GIST pN0 TNM Finding v8 (Gastrointestinal Stromal Tumor Pathologic Regional Lymph Nodes TNM Finding v8)", + "output": "Gastrointestinal Stromal Tumor Pathologic Regional Lymph Nodes TNM Finding v8 described as gastrointestinal stromal tumor without regional lymph node metastasis or unknown lymph node status." + }, + { + "input": "Concept: Bis(Phenol A-Glycydyl Methacrylate) (methyl acrylate)", + "output": "Composite Resins described as the reaction product of bisphenol A and glycidyl methacrylate that undergoes polymerization when exposed to ultraviolet light or mixed with a catalyst. It is used as a bond implant material and as the resin component of dental sealants and composite restorative materials." + }, + { + "input": "Concept: BALA (Laboratory Procedure)", + "output": "Laboratory Procedure described as the determination of the amount of beta alanine present in a sample." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Microbiology, Bacteria, Identification, Neisseria Species (IVD Test Reagent/Kits, Microbiology, Bacteria, Identification)", + "output": "something described as microbiology reagents intended to identify species of Neisseria, a genus of bacteria of the family Neisseriaceae. The genus Neisseria includes several pathologic species, such as N. gonorrhoeae (i.e., gonococci) and N. meningitidis. Neisseria identification reagents may be specific for either manual or automated tests; frequently, these tests are combined with tests to identify Haemophilus bacteria." + }, + { + "input": "Concept: Very Mild Hallucination (Hallucination Severity)", + "output": "Finding described as while resting or going to sleep, sees visions, smells odors or hears voices, sounds, or whispers in the absence of external stimulation, but no impairment in functioning." + }, + { + "input": "Concept: skin stimulation (Therapeutic or Preventive Procedure)", + "output": "Pain management described as the process of applying pressure, friction, temperature change, or chemical substances to the skin to lessen or block a feeling of pain." + }, + { + "input": "Concept: Z-phenylacetaldoxime formation (organic substance biosynthetic process)", + "output": "Z-phenylacetaldoxime metabolic process described as the chemical reactions and pathways resulting in the formation of Z-phenylacetaldoxime, a member of the glucosinolate group of compounds." + }, + { + "input": "Concept: pegfilgrastim ANF (Pharmacologic Substance)", + "output": "something described as a long-acting, engineered and pegylated version of human granulocyte-colony stimulating factor (G-CSF), with potential hematopoietic activity. Similar to G-CSF, pegfilgrastim anti-neutropenic factor (ANF) binds to and activates specific cell surface receptors, and stimulates neutrophil progenitor proliferation and differentiation. Therefore, this agent may prevent the duration and incidence of chemotherapy-induced neutropenia. Compared to filgrastim, the conjugation with a branched polyethylene glycol molecule reduces renal clearance and increases its plasma half-life. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C123927\" active clinical trials using this agent." + }, + { + "input": "Concept: Benign Childhood Brain Neoplasm (Benign neoplasm of brain, unspecified)", + "output": "Benign neoplasm of brain, unspecified described as a non-metastasizing neoplasm that arises from the brain during childhood." + }, + { + "input": "Concept: Pasteurellaceae Pohl 1981 (Gram-Negative Facultatively Anaerobic Rods)", + "output": "Gammaproteobacteria described as gram negative coccoid or rigid rod-shaped bacteria which are facultatively anaerobic and nonmotile." + }, + { + "input": "Concept: Median (Design, Analysis & Interpretation)", + "output": "Quantitative Concept described as the middle value in a data set; that is, just as many values are greater than the median and lower than the median value." + }, + { + "input": "Concept: Macroscopic Findings Evaluator (Evaluator - personnel)", + "output": "something described as a person who determines the significance of a macroscopic findings assessment." + }, + { + "input": "Concept: Kerosolenum, kerosene, Homeopathic preparation (Homeopathic remedies letter K)", + "output": "Organic Chemical described as kerosene." + }, + { + "input": "Concept: IPAQ Long Last 7 Days Telephone Format Version - Moderate Work Hours per Day (Intellectual Product)", + "output": "Intellectual Product described as international Physical Activity Questionnaire (November 2002) - Long Last 7 Days Telephone Format - How much time did you usually spend on one of those days doing moderate physical activities as part of your work?: Hours per day." + }, + { + "input": "Concept: Abdomen+Pelvis>Iliac vessels (Body Part, Organ, or Organ Component)", + "output": "Abdominopelvic structure described as any of the branches of the vessels arising from the common iliac artery or vein, located in the pelvis." + }, + { + "input": "Concept: Ependymomas, Papillary (Ependymoma)", + "output": "something described as a rare variant of ependymoma characterized by well formed papillae. Tumor cell processes abutting capillaries are usually GFAP-positive. Differential diagnoses include choroid plexus papilloma, papillary meningioma and metastatic papillary carcinoma." + }, + { + "input": "Concept: Candidate Gene Identification (Molecular Biology Research Technique)", + "output": "Molecular Biology Research Technique described as the determination of genes suspected to be associated with specific traits, metabolic pathways, or diseases." + }, + { + "input": "Concept: Grade 2 Epistaxis (Finding)", + "output": "Epistaxis, CTCAE described as moderate symptoms; medical intervention indicated" + }, + { + "input": "Concept: insular pole (Body Location or Region)", + "output": "something described as a superficial landmark identified by dissection in the human insula. It represents the surfaces of the accessory insular gyrus and the transverse insular gyrus located at the most anteroinferior aspect of the anterior insula where it meets the frontal lobe ( Ture-1999 ). It is not found in the macaque or the rodent ( NeuroNames )." + }, + { + "input": "Concept: hoodia (Stapeliinae)", + "output": "Plant described as a genus in the dogbane family (Apocynaceae) used in TRADITIONAL MEDICINE for appetite-suppressant properties." + }, + { + "input": "Concept: u[IU]/ml/(mg/d) (Unit of concentration)", + "output": "something described as a unit of concentration (biologic activity) equal to one micro-international unit per milliliter, divided by milligrams per day." + }, + { + "input": "Concept: Pulvinar (Thalamic structure)", + "output": "Thalamic Nuclei described as a predominantly gray matter subdivision of the lateral nuclear group of the thalamus. In the primate it is a topologically prominent component of the thalamus that is itself subdivided into four nuclei based on histology: the anterior pulvinar nucleus, lateral pulvinar nucleus, medial pulvinar nucleus and inferior pulvinar nucleus ( Nomina-1983 ). In the rodent the pulvinar is not distinguishable as a structure distinct from the lateral posterior nucleus ( Swanson-2004 )." + }, + { + "input": "Concept: ICT (Electroanalgesia)", + "output": "Electroanalgesia described as a non-invasive form of electroanalgesia, based on TENS, that uses the principle of amplitude modulation to decrease the discomfort of stimulating deeper tissues when using transcutaneously applied electrical current. It is often used in physiotherapy and rehabilitation settings." + }, + { + "input": "Concept: SREBP 1a (Biologically Active Substance)", + "output": "something described as SREBP1-A is an isoform of sterol regulatory element binding protein 1 that is a potent activator of GENETIC TRANSCRIPTION. It is the predominant form in SPLEEN." + }, + { + "input": "Concept: LUNG, LEFT, SUPERIOR LOBE, APICOPOSTERIOR SEGMENT (Respiratory System Part)", + "output": "something described as the apicoposterior segment of the superior lobe of the left lung." + }, + { + "input": "Concept: HAMA1-Somatic (Intellectual Product)", + "output": "Intellectual Product described as hamilton Anxiety Rating Scale (HAMA) Somatic (sensory); tinnitus, blurring of vision, hot and cold flushes, feelings of weakness, pricking sensation." + }, + { + "input": "Concept: biopsies excisional (Excision)", + "output": "Excision described as a surgical procedure in which an entire lesion is removed for microscopic examination." + }, + { + "input": "Concept: microtubule-based movement (movement of cell or subcellular component)", + "output": "something described as a microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." + }, + { + "input": "Concept: Grade 2 Constipation Neonatal (Neonatal Constipation, Adverse Event)", + "output": "something described as reduced number of stools or hard stools; apparent discomfort; minor care changes indicated." + }, + { + "input": "Concept: Powder for conventional release nebulizer suspension (Inhalation dosage form)", + "output": "Inhalation dosage form described as solid preparation consisting of one or more powders, including freeze-dried powders, intended to be dispersed in the specified liquid to obtain a nebuliser suspension." + }, + { + "input": "Concept: Anatomical spaces (Anatomical spatial entity)", + "output": "Anatomic structures described as general term for any space in the body." + }, + { + "input": "Concept: Cell-Cell Competition (Cell physiology)", + "output": "Cell physiology described as a cellular process that selectively eliminates cells with mutations from further development through short-range cell-cell interaction." + }, + { + "input": "Concept: Recurrent infections due to aspiration (respiratory)", + "output": "Recurrent respiratory infections described as increased susceptibility to infections due to aspiration, as manifested by recurrent episodes of infections due to aspiration. []" + }, + { + "input": "Concept: propionate transmembrane transporter activity (short-chain fatty acid transmembrane transporter activity)", + "output": "short-chain fatty acid transmembrane transporter activity described as enables the transfer of propionate from one side of a membrane to the other. Propionate (or propanoate) is the organic acid CH3-CH2-COOH." + }, + { + "input": "Concept: Intracarotid (Body Location or Region)", + "output": "Anatomy Qualifier described as the inside of the common, external, or internal carotid arteries." + }, + { + "input": "Concept: Superior Innominate Shear (Finding)", + "output": "Finding described as a somatic dysfunction in which the anterior superior iliac spine (ASIS) and posterior superior iliac spines (PSIS) are superior to the contralateral landmarks. The innominate (os coxa) moves more freely in a superior direction and is restricted from movement in an inferior direction." + }, + { + "input": "Concept: Response (Response)", + "output": "Intellectual Product described as a statement (either spoken or written) that is made in reply to a question or request or criticism or accusation; a statement that solves a problem or explains how to solve the problem." + }, + { + "input": "Concept: Percutaneous Route of Administration (Functional Concept)", + "output": "Administration, Mucosal described as administering a medication to a client/patient through his or her skin. Service is billed per treatment." + }, + { + "input": "Concept: fentaNYL citrate (F [Preparations])", + "output": "something described as the citrate salt of fentanyl, a synthetic opioid related to the phenylpiperidines with analgesic and anesthetic properties. Fentanyl exerts its analgesic effect by selectively binding to the mu-opioid receptor in the central nervous system (CNS), thereby mimicking the effects of endogenous opiates. Additional pharmacological effects of fentanyl include anxiolysis, euphoria, feelings of relaxation, respiratory depression, constipation, miosis, and cough suppression." + }, + { + "input": "Concept: up regulation of leukocyte proliferation (Cell Function)", + "output": "Stimulation of Cell Proliferation described as any process that activates or increases the frequency, rate or extent of leukocyte proliferation." + }, + { + "input": "Concept: Angiotensin Precursor (Chemical procedure)", + "output": "Hormone measurement described as the determination of the amount of angiotensinogen hormone present in a sample." + }, + { + "input": "Concept: Renal pelvis fistula (Disease or Syndrome)", + "output": "Disease or Syndrome described as an abnormal communication between the renal pelvis and another anatomic site." + }, + { + "input": "Concept: H1-9 (Histone H1)", + "output": "Histone H1 described as spermatid-specific linker histone H1-like protein (231 aa, ~26 kDa) is encoded by the human H1-9 gene. ThisF1:F143tein is involved in chromatin condensation during spermatogenesis." + }, + { + "input": "Concept: male reproductive system disorder (Disease or Syndrome)", + "output": "Male genitalia finding described as deviation from or interruption of the normal structure or function of the male reproductive system." + }, + { + "input": "Concept: stage 0 transitional cell carcinoma in situ of the renal pelvis and ureter (Transitional cell carcinoma in situ)", + "output": "Transitional cell carcinoma in situ described as stage 0 includes: 0a (Ta, N0, M0); 0is (Tis, N0, M0). Ta: Papillary noninvasive carcinoma. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis." + }, + { + "input": "Concept: Early neonatal death (Finding)", + "output": "Finding described as death of a live newborn during the first 7 days of life." + }, + { + "input": "Concept: (+)-(S)-4,4'-(1-Methyl-1,2-ethanediyl)di(2,6-piperazinedione) (Antineoplastic Agents)", + "output": "Cytoprotective agent described as the (+)-enantiomorph of razoxane." + }, + { + "input": "Concept: new xofc 30min homeo ntak (Remote location new client without ICD diagnosis)", + "output": "Health Care Activity described as using homeopathic assessment methods in a usual, 30-minute, out-of-office meeting to assess the health status of a new homeopathy client to develop a homeopathic treatment plan." + }, + { + "input": "Concept: AQ0104 (Intellectual Product)", + "output": "Intellectual Product described as airway Questionnaire 20 (AQ20) Do you worry when going to a friend's house that there might be something there that will upset your chest?" + }, + { + "input": "Concept: Hanoverian Scenthound (Mammal)", + "output": "Hound described as a calm and assured scent hound with strong loyalty to the hunter in charge. The body is lean and muscular, and the head is slightly wrinkled with a serious expression. The coat is short and primarily red, but can vary from a pale fawn color to a dark brindle. The average height range is 19-21 inches and the average weight range is 79-99 pounds." + }, + { + "input": "Concept: Tabminder (Potency Unit)", + "output": "Potency Unit described as a dosing unit equal to the amount of active ingredient(s) administered by a tabminder." + }, + { + "input": "Concept: Clarke Columns (Nucleus of spinal cord)", + "output": "Segment of dorsal gray column of spinal cord described as a nucleus of round or oval cells located in the medial part of lamina VII in the spinal central gray of thoracic segments and upper lumbar segments of the human ( Carpenter-1983 ) and the rat ( Swanson-2004 ). It is also commonly known as Clarke's column. In the functional model of central nervous system organization it is classified as part of the subcortical somatosensory system ( Swanson-2004 ) (see Models Where It Appears below)." + }, + { + "input": "Concept: Mycosis Fungoides and Sezary Syndrome N2a TNM Finding v8 (Mycosis Fungoides and Sezary Syndrome N2 TNM Finding v8)", + "output": "something described as clone negative. Note: A T-cell clone is defined by polymerase chain reaction (PCR) or Southern blot analysis of the TCR gene." + }, + { + "input": "Concept: Nursing audit (Clinical Audit)", + "output": "Health Care Activity described as a detailed review and evaluation of selected clinical records by qualified professional personnel for evaluating quality of nursing care." + }, + { + "input": "Concept: inhibition of programmed cell death in other organism (modulation of programmed cell death in other organism involved in symbiotic interaction)", + "output": "Cell Function described as any process in which an organism stops, prevents, or reduces the frequency, rate or extent of programmed cell death in a second organism, where the two organisms are in a symbiotic interaction." + }, + { + "input": "Concept: Zarda Tobacco (Central Nervous System Stimulants)", + "output": "Central Nervous System Stimulants described as a combination of tobacco, lime, spices, vegetable dyes, and areca nut. It is typically chewed for its stimulant effects." + }, + { + "input": "Concept: Grade 3 Constipation Neonatal (Neonatal Constipation, Adverse Event)", + "output": "Neonatal Constipation, Adverse Event described as an adverse event in a newborn characterized by reduced number of stools or hard stools; signs of obstruction; apparent discomfort or affecting feeding; major care changes indicated (e.g. long term medical treatment, enema)." + }, + { + "input": "Concept: Sponsor Device Identifier (Identifier)", + "output": "something described as a sponsor-defined sequence of characters used to identify, name, or characterize the device." + }, + { + "input": "Concept: granuloma; midline (Disorder of face)", + "output": "Nose Diseases described as a condition that is characterized by inflammation, ulceration, and perforation of the nose and the PALATE with progressive destruction of midline facial structures. This syndrome can be manifested in several diseases including the nasal type of EXTRANODAL NK-T-CELL LYMPHOMA and GRANULOMATOSIS WITH POLYANGIITIS." + }, + { + "input": "Concept: barosma crenulatum/buchu (Homeopathic remedies letter B)", + "output": "Organic Chemical described as buchu." + }, + { + "input": "Concept: cGMP Measurement (SPECIFIC SUBSTANCE CHEMISTRY TESTS)", + "output": "something described as a measurement of the cyclic guanosine 3,5-monophosphate in a biological specimen." + }, + { + "input": "Concept: HIGH RESOLUTION MELT ANALYSIS (DNA analysis)", + "output": "Laboratory Procedure described as a reverse, real-time, polymerase chain reaction technique in which fluroescently labeled double-stranded DNA is slowly melted apart by increasing temperature. Genetic mutations and polymorphisms can be detected by analyzing the melt curves, which correspond to the rate at which double-stranded DNA become single-stranded." + }, + { + "input": "Concept: Rabbit Cutaneous Lymphoma (Neoplastic Process)", + "output": "something described as cutaneous lymphoma that occurs in a rabbit." + }, + { + "input": "Concept: BERYLLIUM SULFATE (Indicator, Reagent, or Diagnostic Aid)", + "output": "Inorganic Chemical described as a white colored, crystalline, inorganic compound that emits toxic fumes of beryllium oxides and sulfur oxides upon heating. Beryllium sulfate is mainly used to produce beryllium oxide for high-technology ceramics. Inhalation exposure to its dust and fumes irritates the nose, throat and lungs and can cause pneumonitis. Prolonged exposure can result in a chronic beryllium disease called berylliosis causing granuloma and fibrosis formation in the lungs. Beryllium is associated with an increased risk of developing lung cancer." + }, + { + "input": "Concept: Chlorethylamine, Dibenzyl (Ethylamines)", + "output": "Ethylamines described as an alpha adrenergic antagonist." + }, + { + "input": "Concept: VIP (VIP Gene Product)", + "output": "Hormone described as a hormone found in the pancreas, intestine, and central nervous system. It has many actions in the body, such as helping to control the secretion of water, salts, enzymes, and gastric acid during digestion. It also causes smooth muscles in the digestive tract, the heart, and the blood vessels to relax. It also has effects on the immune system and the central nervous system. Certain tumors in the pancreas make large amounts of vasoactive intestinal peptide." + }, + { + "input": "Concept: Absent smell (FUNCTIONS AND DYSFUNCTIONS OF THE CRANIAL NERVES)", + "output": "Abnormality of the sense of smell described as an inability to perceive odors. This is a general term describing inability to smell arising in any part of the process of smelling from absorption of odorants into the nasal mucous overlying the olfactory epithelium, diffusion to the cilia, binding to olfactory receptor sites, generation of action potentials in olfactory neurons, and perception of a smell." + }, + { + "input": "Concept: PROTEIN PHOSPHATASE 1, REGULATORY SUBUNIT 54 (Genes, Regulator)", + "output": "Genes, Regulator described as this gene may play a role in the pathogenesis of certain types of cancer." + }, + { + "input": "Concept: Performed Lesion Description Lesion Number (Number of lesions)", + "output": "something described as the integer assigned to a lesion for a subject. NOTE(S): Once a lesion number is designated for a specific lesion that number may not change or re-used to denote a different lesion." + }, + { + "input": "Concept: Liposomal MUC1/PET-lipid A Vaccine ONT-10 (Pharmacologic Substance)", + "output": "Immunologic Factor described as a cancer vaccine comprised of a 43 amino acid epitope from glycoprotein MUC1 (mucin 1) and the synthetic Toll-like receptor 4 (TLR-4) agonist PET lipid A encapsulated in cholesterol/dipalmitoylphosphatidylcholine (DPPC)/dimyristoylphosphatidylglycerol (DMPG) liposomes, with potential immunostimulatory and antineoplastic activities. The MUC1 epitope is composed of two 20 amino glycosylated VNTR (various number tandem repeats) from human MUC1A and including 6 glycosylated sites modified by Tn (alfa-N-acetyl-D-galactosamine). Immunization of liposomal MUC1/PET-lipid A vaccine ONT-10 results in an antibody as well as a cytotoxic T-lymphocyte (CTL) response against hypoglycosylated MUC1 expressing tumor cells. The tumor associated antigen MUC1, a type I transmembrane protein, is overexpressed and aberrantly glycosylated in a variety of tumor cells. As a vaccine adjuvant, PET lipid A, also known as penta erythritol lipid A, stimulates both cellular and humoral responses to the vaccine antigen." + }, + { + "input": "Concept: Software, Physiologic Measurement, Spirometry (Software, Physiologic Measurement)", + "output": "Intellectual Product described as physiologic measuring software designed to operate spirometers, control/monitor a limited number of their functions, and/or process data obtained while measuring. This software is intended to work only with one or a few models of diagnostic spirometers, usually from the same manufacturer. Spirometer software may perform a variety of algorithms to facilitate the operation and analysis of the measurements (e.g., volume, flow). Spirometer software is not usually available separate from the instrument but may be updated (i.e., through the release of modified versions) during the life of the measuring instrument." + }, + { + "input": "Concept: NEISSERIA GONORRHOEAE, PENICILLINASE NEGATIVE (Neisseria gonorrhoeae)", + "output": "Neisseria gonorrhoeae described as any bacterial species identified as Neisseria gonorrhoeae that does not produce the enzyme penicillinase." + }, + { + "input": "Concept: Nodus cysticus (Lymph node along bile duct)", + "output": "something described as hepatic lymph node located near or on neck of gallbladder." + }, + { + "input": "Concept: type 1 papillary renal cell carcinoma (Neoplastic Process)", + "output": "something described as a type of papillary renal cell carcinoma that is characterized by small cuboidal cells covering thin papillae with a single line of uniform nuclei and small nucleoli." + }, + { + "input": "Concept: Factor XIIIa (Transglutaminases)", + "output": "Activated coagulation factor described as activated form of FACTOR XIII, a transglutaminase, which stabilizes the formation of the fibrin polymer (clot) culminating the blood coagulation cascade." + }, + { + "input": "Concept: performance outcome (Finding)", + "output": "Finding described as a clinical outcome assessment in which a task is performed by a subject under the administration of a healthcare professional." + }, + { + "input": "Concept: GH1 Gene Product (Pituitary Hormones)", + "output": "Pituitary Hormones described as a protein encoded by the GH1 gene." + }, + { + "input": "Concept: down regulation of ER stress response (Cell Function)", + "output": "negative regulation of response to stimulus described as any process that stops, prevents or reduces the frequency, rate or extent of a response to endoplasmic reticulum stress." + }, + { + "input": "Concept: Is Myometrial Invasion Present (CPTAC Questions)", + "output": "Intellectual Product described as a question about whether myometrial invasion is present." + }, + { + "input": "Concept: xstng nfclty 5min (Therapeutic or Preventive Procedure)", + "output": "Existing client in-facility with ICD diagnosis described as evaluating and managing an existing client in a simple, 5-minute, in-facility meeting. This code may be used by providers of services who are able to diagnose." + }, + { + "input": "Concept: 2: 218816252-218827481 (Chromosome 2 Physical Location)", + "output": "Chromosome 2 Physical Location described as physical location of IL8RB_Gene" + }, + { + "input": "Concept: Thyroid Gland Teratoma (Neoplastic Process)", + "output": "Thyroid Neoplasm described as a teratoma that involves, is continuous with, or completely replaces the thyroid gland. It is derived from all three embryonic germ cell layers. According to the level of differentiation of the tissues which comprise the tumor, teratomas are classified as benign (grade 0 or 1), immature (grade 2), and malignant (grade 3). Grade 0 teratomas contain only mature elements; grade 1 teratomas have a limited degree of immaturity; grade 2 teratomas have a more extensive degree of immaturity; grade 3 teratomas are composed exclusively of immature tissues. The prognosis depends on patient age, tumor size, and grade." + }, + { + "input": "Concept: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response (CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)", + "output": "CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation described as the process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell as part of an immune response." + }, + { + "input": "Concept: oppositional defiant disorder (Other or mixed emotional disturbances of childhood or adolescence)", + "output": "Mental disorder in childhood described as recurrent pattern of negativistic, defiant, disobedient, and hostile behavior toward authority figures that persists for at least 6 months and is characterized by frequent occurrence of at least four of the following behaviors: losing temper, arguing with adults, actively defying or refusing to comply with requests or rules of adults, deliberately annoying others, blaming others for own mistakes, easily annoyed, angry or resentful; frequently attention deficit disorders and learning disorders are associated with this disorder." + }, + { + "input": "Concept: PUL02-Lift Heavy Can Diagonally (PUL 2.0 Functional Test Question)", + "output": "something described as performance of the Upper Limb Module for DMD 2.0 (PUL 2.0) Lift heavy can diagonally." + }, + { + "input": "Concept: Rho GTPase Activating Protein 45 Gene Mutation (Gene Mutant)", + "output": "Cell or Molecular Dysfunction described as a change in the nucleotide sequence of the ARHGAP45 gene." + }, + { + "input": "Concept: Occlusion, Dental (ORAL CAVITY AND ESOPHAGEAL FUNCTIONS)", + "output": "something described as relationship of all the components of the masticatory system in normal function; has special reference to the position and contact of the maxillary and mandibular teeth for the highest efficiency during the excursive movements of the jaw that are essential for mastication." + }, + { + "input": "Concept: HOXC11-AS1 (HOTAIR gene)", + "output": "Gene or Genome described as human HOTAIR wild-type allele is located in the vicinity of 12q13.13 and is approximately 13 kb in length. This allele, which encodes HOX transcript antisense RNA, is involved in the negative regulation of HOXD gene transcription." + }, + { + "input": "Concept: Stage II Malignant Ovarian Germ Cell Neoplasm (stage, ovarian germ cell tumor)", + "output": "stage, ovarian germ cell tumor described as the tumor is found in one or both ovaries and has spread into other areas of the pelvis. Stage II ovarian germ cell tumor is divided into stages IIA, IIB, and IIC. In stage IIA, cancer has spread to the uterus and/or the fallopian tubes (the long slender tubes through which eggs pass from the ovaries to the uterus). In stage IIB, cancer has spread to other tissue within the pelvis. In stage IIC, cancer has spread to the uterus and/or fallopian tubes and/or other tissue within the pelvis and cancer cells are found in the fluid of the peritoneal cavity (the body cavity that contains most of the organs in the abdomen)." + }, + { + "input": "Concept: regulation of cilium movement (regulation of microtubule-based movement)", + "output": "regulation of microtubule-based movement described as any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." + }, + { + "input": "Concept: Ig Lambda-1 Chain C Regions (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as ig lambda-1 chain C regions (106 aa, ~11 kDa) is encoded by the human IGLC1 gene. This protein plays a role in the structure and function of IgG molecules." + }, + { + "input": "Concept: Broad middle bone of the 4th finger (Broad middle phalanx of finger)", + "output": "Broad phalanges of the 4th finger described as increased width of the middle phalanx of the 4th finger." + }, + { + "input": "Concept: Isaviruses (Virus)", + "output": "Virus described as a genus in the family ORTHOMYXOVIRIDAE containing one species: Infectious salmon anemia virus." + }, + { + "input": "Concept: Esophageal diverticulosis (Esophageal Diseases)", + "output": "Esophageal Diseases described as a pathological condition characterized by the presence of a number of ESOPHAGEAL DIVERTICULA in the ESOPHAGUS." + }, + { + "input": "Concept: CD81 Gene (Transmembrane Protein Gene)", + "output": "something described as this gene may play a role in signal transduction." + }, + { + "input": "Concept: Infectious hepatitis virus (Human enterovirus)", + "output": "Hepatovirus described as a virus that causes a serious liver disease. It is usually spread by contact with an infected person's stool by eating food he or she has handled after not washing hands, but it can be spread in other ways. Symptoms of infection include jaundice, dark urine, and fever and other flu-like symptoms." + }, + { + "input": "Concept: PODCI2-Comp Sports Limited by: Pain (Intellectual Product)", + "output": "something described as pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported Version (PODCI Adolescent Parent-Reported Version) If you answered \"no\" to Question 52 above, was your child's activity limited by: Pain?" + }, + { + "input": "Concept: Clara cell differentiation activity (lung epithelial cell differentiation)", + "output": "lung epithelial cell differentiation described as the process in which a relatively unspecialized cell acquires specialized features of a club cell. A club cell is an unciliated epithelial cell found in the respiratory and terminal bronchioles." + }, + { + "input": "Concept: Sclera (Body Part, Organ, or Organ Component)", + "output": "Wall of eyeball described as the white, opaque, fibrous, outer tunic of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea. It is essentially avascular but contains apertures for vessels, lymphatics, and nerves. It receives the tendons of insertion of the extraocular muscles and at the corneoscleral junction contains the canal of Schlemm." + }, + { + "input": "Concept: GAD-7 Version 2 - Total Score (GAD-7 Version 2 Questionnaire Question)", + "output": "Intellectual Product described as generalized Anxiety Disorder - 7 Version 2 (GAD-7 Version 2) Total score." + }, + { + "input": "Concept: Right to privacy maintained (Social context finding)", + "output": "Finding described as the patient's personal privacy, confidentiality, and security within the perioperative environment are maintained. This includes: maintaining the patient's privacy; securing patient records, personal belonging, and valuables; entering appropriate and accurate information into the patient record; and maintaining confidentiality of patient information." + }, + { + "input": "Concept: IgA heavy chain disease, NOS (Intestinal Neoplasms)", + "output": "Small Intestinal B-Cell Non-Hodgkin Lymphoma described as a clonal disorder, also known as immunoproliferative small intestinal disease or Mediterranean lymphoma, characterised by the secretion of a defective alpha heavy chain. It predominantly affects young people in the Mediterranean region. It involves the small intestine, and patients usually present with malabsorption syndrome, abdominal pain, weight loss, and fever. There is extensive villous atrophy of the small intestinal mucosa, which is heavily infiltrated by small lymphocytes and plasma cells. The small intestinal morphologic changes are consistent with a mucosa-associated lymphoid tissue lymphoma (MALT lymphoma)." + }, + { + "input": "Concept: Paget's disease and intraductal carcinoma of breast (Paget Disease of the Breast without Invasive Carcinoma)", + "output": "Ductal, lobular AND/OR medullary neoplasm described as paget disease of the breast associated with the presence of a usually high grade ductal carcinoma in situ in the lactiferous glands." + }, + { + "input": "Concept: HER2-targeting Agent (Targeted Therapy Agent)", + "output": "Organic Chemical described as any agent that targets the receptor tyrosine kinase human epidermal growth factor receptor 2 (HER2/neu; HER-2; erbB-2)." + }, + { + "input": "Concept: positive regulation of ergosterol biosynthetic process (positive regulation of cellular biosynthetic process)", + "output": "positive regulation of cellular biosynthetic process described as any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol." + }, + { + "input": "Concept: Serine protease (Peptide Hydrolases)", + "output": "Medicinal product categorized by disposition described as proteases that have a serine residue in the active center of the enzyme. These enzymes catalyze the hydrolysis of covalent peptidic bonds by serine nucleophilic attack. Serine proteases participate in a wide range of functions in the body, including blood clotting, inflammation, and digestion." + }, + { + "input": "Concept: DACT2 (Amino Acid, Peptide, or Protein)", + "output": "Signaling Protein described as dapper homolog 2 (774 aa, ~83 kDa) is encoded by the human DACT2 gene. This protein is involved in the inhibition of signal transduction." + }, + { + "input": "Concept: Recurrent Pleomorphic Xanthoastrocytoma (Neoplastic Process)", + "output": "Recurrent Childhood Astrocytic Tumor described as the reemergence of pleomorphic xanthoastrocytoma in childhood after a period of remission." + }, + { + "input": "Concept: PtdIns metabolism (Glycerophospholipid metabolic process)", + "output": "Glycerophospholipid metabolic process described as the chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." + }, + { + "input": "Concept: Fascicle - nerve fibers (Nerve Tissue)", + "output": "Tissue described as a small bundle of nerve fibers that is more or less associated functionally." + }, + { + "input": "Concept: Verrucous Carcinoma of the Vagina (Neoplastic Process)", + "output": "Squamous cell carcinoma of vagina described as a squamous cell carcinoma that arises from the vagina and is characterized by a papillary growth pattern, acanthotic epithelium with minimal or absent atypia, and pushing borders." + }, + { + "input": "Concept: Benzenesulfonamide, 3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]-4-propoxy- (cGMP Phosphodiesterase Inhibitor)", + "output": "cGMP Phosphodiesterase Inhibitor described as a benzenesulfonamide derivative with vasodilatory activity. Udenafil selectively inhibits phosphodiesterase type 5 (PDE5), thus inhibiting the degradation of cyclic guanosine monophosphate (cGMP) found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis; inhibition of cGMP degradation results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, and, so, prolonged penile erection. This agent does not significantly inhibit the PDE11 isozyme; PDE11 inhibition may be associated with significant myalgia. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C74086\" active clinical trials using this agent." + }, + { + "input": "Concept: Implementation of protective measures to prevent skin and tissue injury due to chemical sources (Therapeutic or Preventive Procedure)", + "output": "Preoperative preparation of skin described as prevents skin and tissue trauma secondary to chemical agents including antimicrobial agents, chemical disinfectants, liquid sterilants, irrigation solutions, ethylene oxide, methylmethacrylate, and tissue preservatives." + }, + { + "input": "Concept: beta-catenin-TCF4 complex location (beta-catenin-TCF complex)", + "output": "Cell Component described as a protein complex that contains beta-catenin and TCF7L2 (TCF4), binds to the TCF DNA motif within a promoter element, and is involved in the regulation of WNT target gene transcription." + }, + { + "input": "Concept: Surgical Retractor Kits, Spine, Total (Medical Device)", + "output": "something described as spine surgery retractor kits designed for use while performing procedures involving any or all of the spine (i.e., backbones) segments. These kits typically consist of a collection of devices, instruments, and supplies combined to temporarily separate and retain tissue or other anatomical parts, exposing and/or giving access to the appropriate segment of the spine without manual support once they are set (i.e., self-retained). The kits frequently include a flexible ring, a set of detachable blades which provide lateral retraction, ratchet mechanisms to adjust retractor tension and depth, and a fixation post that may be attached to the operating table or a stand. Total spine retractor kits provide hands-free assistance to the surgeon during the procedure." + }, + { + "input": "Concept: Anti-PD-1 Monoclonal Antibody MEDI0680 (Anti-PD1 Monoclonal Antibody)", + "output": "Amino Acid, Peptide, or Protein described as a humanized immunoglobulin (Ig) G4 monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed cell death 1 (PD-1), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-PD-1 monoclonal antibody MEDI0680 binds to and inhibits PD-1 and its downstream signaling pathways. This may restore immune function through the activation of T-cells and cell-mediated immune responses against tumor cells. PD-1, a transmembrane protein in the Ig superfamily expressed on T cells, functions as an immune checkpoint that negatively regulates T-cell activation and effector function when activated by its ligands programmed cell death ligand 1 (PD-L1) or 2 (PD-L2); it plays an important role in tumor evasion from host immunity." + }, + { + "input": "Concept: 3p21.1 (Chromosome band)", + "output": "Chromosome band described as a chromosome band present on 3p" + }, + { + "input": "Concept: RBM6 protein, human (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as RNA-binding protein 6 (1123 aa, ~129 kDa) is encoded by the human RBM6 gene. This protein is involved in RNA recognition." + }, + { + "input": "Concept: Fixed Tables, Examination/Treatment (Medical Device)", + "output": "Medical Device described as examination/treatment tables designed to maintain a fixed, nonadjustable, height and body position. These tables usually have a padded top surface covered with dirt and stain resistant material (e.g., vinyl) to facilitate cleaning and decontamination and to increase the useful life of the table. Fixed examination/treatment tables are used mainly in hospitals (e.g., for outpatient examination), doctor's offices, and in other healthcare facilities for general, nonspecialized examinations and/or minor treatments." + }, + { + "input": "Concept: giants (hypothalmic/pituitary)", + "output": "Bone Diseases, Endocrine described as condition of abnormal overgrowth or excessive size of the whole body or any of its parts." + }, + { + "input": "Concept: HER2-targeted Liposomal Doxorubicin Hydrochloride MM-302 (Pharmacologic Substance)", + "output": "Doxorubicin Preparation described as an antibody-targeted lipidic nano-carrier containing the antineoplastic anthracycline antibiotic doxorubicin encapsulated within liposomes, and conjugated to a monoclonal antibody against the human epidermal growth factor receptor 2 (HER2), with potential antitumor activity. Upon administration of HER2-targeted liposomal doxorubicin hydrochloride MM-302, the immunoliposome allows for specific delivery of doxorubicin to tumors overexpressing the HER2 receptor. Once inside the HER2-expressing tumor cells, doxorubicin intercalates into DNA and interferes with topoisomerase II activity, thereby inhibiting DNA replication and RNA synthesis. Compared to doxorubicin alone or liposomal doxorubicin, targeted liposomal delivery of doxorubicin improves efficacy while lowering the toxicity profile. HER2, a tyrosine kinase receptor, is overexpressed in many cancer cell types." + }, + { + "input": "Concept: Nerve rootlet complex of spinal nerve (Body Part, Organ, or Organ Component)", + "output": "Body Part, Organ, or Organ Component described as segment of nerve which consists of two or more rootlets continuous proximally with anterior or posterior column nucleus of spinal nerve and continuous distally with anterior or posterior root of spinal nerve." + }, + { + "input": "Concept: Adnexal Mucinous Carcinoma (Mucinous Adenocarcinoma)", + "output": "Sweat gland carcinoma described as a rare low-grade carcinoma of the sweat glands. The most common sites are eyelids, scalp, axilla, face and trunk. It is histologically characterized by proliferating ducts until the overproduction of mucin creates islands of tumor cells, essentially floating in mucinous pools (Rosai J. Ackerman's Surgical Pathology)." + }, + { + "input": "Concept: licartin (Radioimmunoconjugates)", + "output": "Radioimmunoconjugates described as an immunoradioconjugate containing metuximab, an antibody fragment targeting the hepatocellular cancer (HCC)-associated antigen HAb18G/CD147, that is conjugated to the radioisotope iodine I 131, with potential antineoplastic activity. Upon administration, the metuximab moiety of licartin targets and binds to HAb18G/CD147 on HCC cells; upon internalization, the radioisotope I 131 delivers a cytotoxic dose of gamma radiation, thereby causing selective destruction of HAb18G/CD147-expressing cells. HAb18G/CD147, a member of CD147 family, is overexpressed in HCC and fibroblasts and its expression is associated with cancer cell progression and increased adhesion, invasion and metastasis." + }, + { + "input": "Concept: 12: 51777716-51782391 (Chromosome 12 Physical Location)", + "output": "something described as physical location of IGFBP6_Gene" + }, + { + "input": "Concept: succinyl-CoA:(R)-citramalate CoA transferase activity (CoA-transferase activity)", + "output": "something described as catalysis of the reaction: succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA." + }, + { + "input": "Concept: microcephaly, normal intelligence, and immunodeficiency (DNA Repair-Deficiency)", + "output": "Disorder of immune structure described as a disorder, wherein unstable chromosomes have a tendency to break and become rearranged, characterized by microcephaly, stunted growth, subnormal mental development, cafe-au-lait spots, and immunodeficiency. The syndrome is named after the University of Nijmegen in the Netherlands. (JABL99) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C4692\" active clinical trials using this agent." + }, + { + "input": "Concept: Localized edema (Finding)", + "output": "General Disorders and Administration Site Conditions, CTCAE described as a disorder characterized by swelling due to excessive fluid accumulation at a specific anatomic site." + }, + { + "input": "Concept: QIDS-C - Mood (QIDS-C Clinical Classification Question)", + "output": "something described as quick Inventory of Depressive Symptomatology Clinician-Rated Version (QIDS-C) Please circle one response to each item that best describes the patient for the last seven days: Mood (sad)." + }, + { + "input": "Concept: Painful menorrhoea (UTERINE/ENDOMETRIAL DISORDERS)", + "output": "Muscle Cramp described as difficult and painful menstruation." + }, + { + "input": "Concept: BD (Asia)", + "output": "South Central Asia described as a country in Southern Asia, bordering the Bay of Bengal, between Burma and India. The capital is Dhaka." + }, + { + "input": "Concept: 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido(2,3-d)pyrimidine (Dihydrofolate Reductase Inhibitors)", + "output": "Organic Chemical described as a synthetic antifolate agent with antiparasitic, antipsoriatic and antitumor properties. Piritrexim inhibits the enzyme dihydrofolate reductase enzyme, thereby disrupting folate metabolism and DNA synthesis and cell division." + }, + { + "input": "Concept: Musculus flexor digitorum profundus (Flexor of wrist joint)", + "output": "Structure of flexor digitorum muscle of hand described as a muscle in the forearm beginning at the head of the ulna and ending with four tendons projecting to the second, third, fourth, and fifth fingers which flexes the midcarpal, metacarpophalangeal and interphalangeal joints." + }, + { + "input": "Concept: area d23b (area d23)", + "output": "area d23 described as one of two parts of area d23 in the posterior cingulate gyrus of the human and the macaque. It is the part further from the retrosplenial cortex and the corpus callosum.The other part is area d23a. ( Vogt-2012 )." + }, + { + "input": "Concept: splicing inhibitor H3B-8800 (Antineoplastic Agents)", + "output": "Organic Chemical described as an orally bioavailable inhibitor of the splicing factor 3B subunit 1 (SF3B1), with potential antineoplastic activity. Upon administration, H3B-8800 binds to and blocks the activity of SF3B1, a core spliceosome protein that is mutated in various cancer cells. This modulates RNA splicing by preventing aberrant mRNA splicing by the spliceosome, blocks RNA mis-splicing, enhances proper RNA splicing and prevents the expression of certain tumor-associated genes. This leads to an induction of apoptosis and prevents tumor cell proliferation. In many cancer cells, core spliceosome proteins, including SF3B1, U2 small nuclear ribonucleoprotein auxiliary factor 1 (U2AF1), serine/arginine-rich splicing factor 2 (SRSF2) and U2 small nuclear ribonucleoprotein auxiliary factor subunit-related protein 2 (ZRSR2), are mutated and aberrantly activated leading to a dysregulation of mRNA splicing." + }, + { + "input": "Concept: adenosine metabolic process (Molecular Function)", + "output": "something described as the chemical reactions and pathways involving adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." + }, + { + "input": "Concept: dTDP-rhamnose anabolism (nucleotide-sugar biosynthetic process)", + "output": "something described as the chemical reactions and pathways resulting in the formation of dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate." + }, + { + "input": "Concept: Gadolinium, NOS (G [Preparations])", + "output": "Element, Ion, or Isotope described as an element of the rare earth family of metals. It has the atomic symbol Gd, atomic number 64, and atomic weight 157.25. Its oxide is used in the control rods of some nuclear reactors." + }, + { + "input": "Concept: Basses (Perciformes)", + "output": "Perciformes described as common name for FISHES belonging to the order Perciformes and occurring in three different families." + }, + { + "input": "Concept: mannosyl-inositol phosphorylceramide phospholipase activity (inositol phosphorylceramide phospholipase activity)", + "output": "something described as catalysis of the reaction: mannosyl-inositol phosphorylceramide + H2O = C26-phytoceramide + mannosylphosphorylinositol." + }, + { + "input": "Concept: Proctitis (Finding)", + "output": "something described as a disorder characterized by inflammation of the rectum." + }, + { + "input": "Concept: Synonymous Coding SNP (Nucleotide Sequence)", + "output": "Nucleotide Sequence described as synonymous Coding SNP consists of a variation at an appreciable frequency between individuals of a single interbreeding population of a single nucleotide, due to base substitution, at an equivalent location within a protein-coding region of a gene that causes no amino acid change in the protein product and no detectable phenotypic effect; a silent mutation." + }, + { + "input": "Concept: Fatty Acid Synthase, Type II (Enzyme)", + "output": "something described as the form of fatty acid synthase complex found in BACTERIA; FUNGI; and PLANTS. Catalytic steps are like the animal form but the protein structure is different with dissociated enzymes encoded by separate genes. It is a target of some ANTI-INFECTIVE AGENTS which result in disruption of the CELL MEMBRANE and CELL WALL." + }, + { + "input": "Concept: Glycoprotein, 34-kD Gene (TNFSF4 gene)", + "output": "something described as human TNFSF4 wild-type allele is located within 1q25 and is approximately 24 kb in length. This allele, which encodes tumor necrosis factor ligand superfamily member 4 protein, is involved in T cell antigen-presenting cell interactions, cytokine production and cellular proliferation." + }, + { + "input": "Concept: COPI coating of Golgi vesicle (Golgi transport vesicle coating)", + "output": "Cell Function described as the addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of transport vesicles, forming a vesicle coat." + }, + { + "input": "Concept: CDISC ADAS-Cog - Word Recognition: Word 16 (Intellectual Product)", + "output": "something described as alzheimer's Disease Assessment Scale-Cognitive CDISC Version - Word recognition task for word 16 Trials 1, 2, 3." + }, + { + "input": "Concept: Complement Protein (Immune system)", + "output": "Protein, Organized by Function described as one of a group of about 20 proteins that is found in the blood and is important in fighting infections and other diseases." + }, + { + "input": "Concept: spinal cord imaging/visualization (Neuroimaging)", + "output": "Diagnostic Procedure described as visual display of structural or functional patterns of the spinal cord as a whole or any of its parts for diagnostic evaluation or imaging of anatomical structures; includes measuring physiologic and metabolic responses to physical and chemical stimuli." + }, + { + "input": "Concept: regulation of tRNA methylation (Genetic Function)", + "output": "something described as any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tRNA methylation." + }, + { + "input": "Concept: Sutherland Fulcrum (Physiological Processes)", + "output": "Clinical Attribute described as a shifting suspension fulcrum of the reciprocal tension membrane located along the straight sinus at the junction of the falx cerebri and tentorium cerebelli." + }, + { + "input": "Concept: Methionine Aminopeptidase 2 Inhibitor M8891 (Antineoplastic Enzyme Inhibitor)", + "output": "Pharmacologic Substance described as a proprietary orally available inhibitor of methionine aminopeptidase 2 (MetAP2), which cleaves the amino-terminal methionine residue from nascent proteins, with potential antiangiogenic and antineoplastic activities. Upon administration, MetAP2 inhibitor M8891 inhibits MetAP2 aminopeptidase activity and impairs protein synthesis, which may lead to a decrease in endothelial cell proliferation. Decreased proliferation of endothelial cells results in reductions of both angiogenesis and the growth and spread of solid tumors that are dependent on new blood vessel formation. MetAP2, a metallopeptidase, is involved in promoting protein synthesis and endothelial cell proliferation." + }, + { + "input": "Concept: Antibody Toxin Hybrid (Pharmacologic Substance)", + "output": "Biological Factors described as an antibody linked to a toxic substance. Some immunotoxins can bind to cancer cells and kill them." + }, + { + "input": "Concept: DHE (Azoles)", + "output": "something described as the purified component of HEMATOPORPHYRIN DERIVATIVE, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (HEMATOPORPHYRIN PHOTORADIATION); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of PHOTODYNAMIC THERAPY in the United States." + }, + { + "input": "Concept: stereocilia ankle link complex (protein-containing complex)", + "output": "something described as a complex of proteins that connect growing stereocilia in developing cochlear hair cells, composed of Vlgr1, usherin, vezatin, and whirlin." + }, + { + "input": "Concept: cellular response to ionic osmotic stress (cellular response to osmotic stress)", + "output": "Cell Function described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." + }, + { + "input": "Concept: NYREN8 (Gene or Genome)", + "output": "PPP2R3B gene described as human PPP2R3B wild-type allele is located the vicinity of either Xp22.33 or Yp11.3 and is approximately 53 kb in length. This allele, which encodes serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta protein, plays a role in the modulation of cellular proliferation." + }, + { + "input": "Concept: Sanguis (Body substance)", + "output": "HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS described as portion of body substance which has as its parts plasma and blood cells." + }, + { + "input": "Concept: regulation of translation in response to osmotic stress (Osmoregulation)", + "output": "Osmoregulation described as any process that modulates the frequency, rate or extent of the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." + }, + { + "input": "Concept: Wirehaired pointing griffon dog (Mammal)", + "output": "Canis familiaris described as a rough-coated, medium-sized dog. It has a large, long head, square muzzle, and soft, thick, bushy eyebrows, beard and mustache. It has a straight, hard, wiry outer coat which is lined with a fine but thick downy undercoat. The coat comes in silver or steel-grey with chestnut or roam markings, or in solid chestnut. The average height range is 20-24 inches and the average weight range is 50-60 pounds." + }, + { + "input": "Concept: Mazindole (Benzimidazoles)", + "output": "other non-amphetamine anorexics described as tricyclic anorexigenic agent unrelated to and less toxic than AMPHETAMINE, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter." + }, + { + "input": "Concept: Order Perissodactyla (Mammal)", + "output": "UNGULATES - HOOFED MAMMALS described as an order of ungulates having an odd number of toes, including the horse, tapir, and rhinoceros." + }, + { + "input": "Concept: descending thin limb development (Organ or Tissue Function)", + "output": "anatomical structure development described as the process whose specific outcome is the progression of the descending thin limb over time, from its formation to the mature structure. The descending thin limb is a part of the loop of Henle situated just after the proximal straight tubule (S3). It extends to the tip of the loop of Henle." + }, + { + "input": "Concept: Pains, Flank (Abdominal Pain)", + "output": "Urinary tract signs and symptoms NEC described as an unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) and perceived to originate in the flank. []" + }, + { + "input": "Concept: Thumb hypoplasia (Congenital musculoskeletal anomalies)", + "output": "Finding of musculoskeletal structure of thumb described as a congenital abnormality characterized by hypoplasia or absence of the thumb. It may be associated with other congenital abnormalities." + }, + { + "input": "Concept: negative regulation of nucleotide degradation (negative regulation of cellular catabolic process)", + "output": "something described as any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." + }, + { + "input": "Concept: Calcimedin (Protein Family)", + "output": "something described as family of proteins which bind phospholipids in the presence of calcium, believed to mediate intracellular calcium's role in membrane fusion and related events such as exocytosis; lipocortin and endonexin may also function extracellularly as inhibitors of phospholipase and blood coagulation." + }, + { + "input": "Concept: Dysarthric speech (CRANIA NERVE ABNORMALITIES)", + "output": "late cerebrovascular disease effects: speech and language deficit described as slow and slurred speech resulting from inability to coordinate the muscles that are used in speech. Causes include brain damage, Parkinson disease, and developmental causes." + }, + { + "input": "Concept: Hypothetical LOC145788 Gene (C15orf65 gene)", + "output": "Gene or Genome described as human C15orf65 wild-type allele is located in the vicinity of 15q21.3 and is approximately 10 kb in length. This allele, which encodes uncharacterized protein C15orf65, has no known function." + }, + { + "input": "Concept: Archival (Action)", + "output": "Functional Concept described as collected and stored for long-term retrieval." + }, + { + "input": "Concept: Bashkiria (Russia)", + "output": "something described as a political subdivision of eastern RUSSIA located within Europe. It consists of a plateau and mountainous area of the Southern Urals." + }, + { + "input": "Concept: Suspension, Extended Release (Extended Release Dosage Form)", + "output": "Biomedical or Dental Material described as a suspension that is designed to release active and/or inert ingredient(s) at a controlled, prolonged rate so as to reduce dosing frequency." + }, + { + "input": "Concept: Reagents, Immunoassay, Therapeutic Drug (Medical Device)", + "output": "something described as immunoassay reagents intended to perform quantitative analyses on a body fluid sample (e.g., serum, urine) to identify and/or measure the levels of one or more of a group of chemical compounds administered to humans for diagnosis, treatment, or prevention of a disease or other abnormal condition or for the relief of pain (i.e., therapeutic drugs) present in the sample. These reagents are used in tests intended to monitor therapeutic drugs such as antibiotics, drugs for the cardiovascular and nervous systems, antiasthmatic drugs, antineoplastic drugs, immunosuppressants, and pain relievers." + }, + { + "input": "Concept: Right Atrial Appendage (Heart part)", + "output": "Body Part, Organ, or Organ Component described as the ear-shaped, muscular pouch of the right atrium." + }, + { + "input": "Concept: PROPHYLAXIS DENT (Therapeutic or Preventive Procedure)", + "output": "Preventive Dentistry described as treatment for the prevention of periodontal diseases or other dental diseases by the cleaning of the teeth in the dental office using the procedures of DENTAL SCALING and DENTAL POLISHING. The treatment may include plaque detection, removal of supra- and subgingival plaque and calculus, application of caries-preventing agents, checking of restorations and prostheses and correcting overhanging margins and proximal contours of restorations, and checking for signs of food impaction." + }, + { + "input": "Concept: Protein Phosphorylation Inhibition (Molecular Function)", + "output": "something described as protein Phosphorylation Inhibition involves interference with, or restraint of, enzymatic activities involved in covalent transfer of a phosphate group from ATP to a protein via the action of a kinase. The major phosphoryl acceptors in proteins are serine, threonine, and tyrosine. Typically, such post-translational modifications regulate protein function." + }, + { + "input": "Concept: Histone Cluster 2, H3d Gene (Gene or Genome)", + "output": "something described as human H3C13 wild-type allele is located in the vicinity of 1q21.2 and is approximately 1 kb in length. This allele, which encodes histone H3.2 protein, plays a role in the incorporation of DNA into nucleosomes." + }, + { + "input": "Concept: Pathologic Stage 0 Esophageal Adenocarcinoma AJCC v8 (High grade glandular intraepithelial neoplasia)", + "output": "something described as stage 0 includes: Tis, N0, M0, GN/A. Tis: High-grade dysplasia, defined as malignant cells confined to the epithelium by the basement membrane. N0: No regional lymph node metastasis. M0: No distant metastasis. GN/A: Grade non-applicable." + }, + { + "input": "Concept: ng*h2/mL (Measurement Unit Description)", + "output": "Measurement Unit Description described as hours squared times nanograms per milliliter." + }, + { + "input": "Concept: (mL/day)/(ug/day) (Quantitative Concept)", + "output": "Unit of Dose Calculation described as a unit of concentration equal to liter per day divided by milligram per day." + }, + { + "input": "Concept: Ovarian Cystic Teratoma (Cystic teratoma)", + "output": "something described as a teratoma that arises from the ovary and is characterized by the presence of cystic structures. Representative example is the dermoid cyst." + }, + { + "input": "Concept: DEP Domain-Containing mTOR-Interacting Protein (Signaling Protein)", + "output": "something described as DEP domain-containing mTOR-interacting protein (409 aa, ~46 kDa) is encoded by the human DEPTOR gene. This protein plays a role in the regulation of mTOR signaling." + }, + { + "input": "Concept: Stage 0a Renal Pelvis and Ureter Cancer AJCC v8 (Neoplastic Process)", + "output": "Papillary transitional cell carcinoma, non-invasive described as stage 0a includes: Ta, N0, M0. Ta: Papillary noninvasive carcinoma. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C140358\" active clinical trials using this agent." + }, + { + "input": "Concept: positive regulation of bone marrow cell proliferation (Cell Function)", + "output": "regulation of cell proliferation in bone marrow described as a process that activates or increases the frequency, rate or extent of cell proliferation in the bone marrow." + }, + { + "input": "Concept: Alcohol Rehabilitation (drug and alcohol detoxification and rehabilitation)", + "output": "therapy for alcohol abuse or dependence described as treatment for alcoholism or alcohol abuse which may include detoxification, psychotherapy, behavior therapy, Alcoholics Anonymous, and medication." + }, + { + "input": "Concept: allogeneic partially HLA-matched VST (Cell)", + "output": "something described as a population of closely human leukocyte antigen (HLA)-matched, donor-derived cytotoxic T lymphocytes (CTLs) that are specifically reactive towards five viruses, Epstein-Barr virus (EBV), cytomegalovirus (CMV), adenovirus (AdV), human herpesvirus 6 (HHV6), and human polyomavirus type I (BKV), with potential antiviral activity. Infusion of the multivirus-specific CTLs into allogeneic hematopoietic stem cell transplant (HSCT) recipients provides virus-specific cellular immunity and causes specific anti-viral effects against active viral infections. The administered CTLs also prevent EBV, CMV, AdV, HHV6, and BKV reactivation and infection as well as inhibiting viral-associated diseases in immunocompromised patients. The allogeneic multivirus-specific CTLs may also provide cellular immunity towards the human polyomavirus type II (JC virus; JCV), which is highly homologous to BKV." + }, + { + "input": "Concept: Christian Science treatment face-to-face each 5 minutes (Therapeutic or Preventive Procedure)", + "output": "Therapeutic or Preventive Procedure described as providing Christian Science prayer to a client/patient in a face-to-face meeting, to affect healing and/or curing of his or her body, mind and/or spirit. Any practitioner using this code must be listed in The Christian Science Journal as a Christian Science practitioner. Service is billed in 5-minute increments." + }, + { + "input": "Concept: Nutritional Rickets (Rickets)", + "output": "something described as rickets due to dietary deficiency of calcium, phosphate, or vitamin D." + }, + { + "input": "Concept: immunoglobulin complex location (protein-containing complex)", + "output": "protein-containing complex described as a protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." + }, + { + "input": "Concept: PNP-Expressing Ovine Atadenovirus FP253 (Amino Acid, Peptide, or Protein)", + "output": "something described as an ovine atadenovirus encoding E. coli purine nucleoside phosphorylase (PNP) with prodrug activating activity. Under the control of a prostate-directed promoter, PNP-expressing atadenovirus vaccine FP253 expresses PNP in prostate tissue only after intraprostatic administration; this enzyme catalyzes systemically administered fludarabine prodrug into the active agent, 2-fluoroadenine. Localized prodrug activation provides prostate-targeted chemotherapy, potentially reducing systemic side effects." + }, + { + "input": "Concept: Skeletin (Intermediate Filament Proteins)", + "output": "Intermediate Filament Proteins described as an intermediate filament protein found predominantly in smooth, skeletal, and cardiac muscle cells. Localized at the Z line. MW 50,000 to 55,000 is species dependent." + }, + { + "input": "Concept: Microwave Radiation (Sterilization for infection control)", + "output": "Sterilization for infection control described as a sterilization process that uses microwave radiation to kill microorganisms. This process is restricted to materials that contain water and is typically used for food." + }, + { + "input": "Concept: CATHETER, BALLOON TYPE (Medical Device)", + "output": "Medical Device described as an introduction/drainage catheter is a device that is a flexible single or multilumen tube intended to be used to introduce nondrug fluids into body cavities other than blood vessels, drain fluids from body cavities, or evaluate certain physiologic conditions. Examples include irrigation and drainage catheters, pediatric catheters, peritoneal catheters (including dialysis), and other general surgical catheters. An introduction/drainage catheter accessory is intended to aid in the manipulation of or insertion of the device into the body. Examples of accessories include adaptors, connectors, and catheter needles." + }, + { + "input": "Concept: DRRI1-J: Leaders Interested in Welfare (DRRI-2 Questionnaire Question)", + "output": "DRRI-2 Questionnaire Question described as deployment Risk & Resilience Inventory-2 - During deployment: the leaders of my unit were interested in my personal welfare." + }, + { + "input": "Concept: WD7D3 3 (Intellectual Product)", + "output": "something described as world Health Organization Disability Assessment Schedule 2.0 - 36-Item Self - In the past 30 days, how much difficulty did you have in: Eating?" + }, + { + "input": "Concept: Palatum (Head part)", + "output": "Oral region described as the roof of the mouth. The front portion is bony (hard palate), and the back portion is muscular (soft palate)." + }, + { + "input": "Concept: d.ng/ml/g (Measurement Unit Description)", + "output": "Measurement Unit Description described as days times micrograms per milliliter, divided by kilograms." + }, + { + "input": "Concept: PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Child - Hard to Swallow Food (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Child Questionnaire Question)", + "output": "PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Child Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Acute Version 3.0 Parent Report for Child (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Child) In the past 7 days, how much of a problem has this been for your child: It is hard for my child to swallow food." + }, + { + "input": "Concept: talk (Communicating - producing)", + "output": "something described as producing words, phrases and longer passages in spoken messages with literal and implied meaning, such as expressing a fact or telling a story in oral language." + }, + { + "input": "Concept: regulation of IL-23 biosynthesis (regulation of interleukin-23 production)", + "output": "regulation of cytokine biosynthetic process described as any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23." + }, + { + "input": "Concept: Nutrition encounter ratio (Nutritional observable)", + "output": "Nutritional observable described as the ratio of actual nutrition encounters to the total planned nutrition encounters" + }, + { + "input": "Concept: channel-forming ionophore activity (Molecular Function)", + "output": "channel activity described as enables transport of a solute across a membrane. This kind of transporter interacts much more weakly with the solute than the carrier does. It is an aqueous pore that extends across the membrane. It may change from closed to open and back. It transports faster than a carrier. It is always passive." + }, + { + "input": "Concept: regulation of 5,10-methylenetetrahydrofolate reductase (NADPH) activity (regulation of oxidoreductase activity)", + "output": "something described as any process that modulates the frequency, rate or extent of methylenetetrahydrofolate reductase (NAD(P)H) activity." + }, + { + "input": "Concept: 14q32 (Cell Component)", + "output": "Cell Component described as a chromosome band present on 14q" + }, + { + "input": "Concept: Processes, Climatic (Ecological and Environmental Phenomena)", + "output": "Ecological and Environmental Phenomena described as characteristic events occurring in the ATMOSPHERE during the interactions and transformation of various atmospheric components and conditions." + }, + { + "input": "Concept: Structure of helicotrema (Ostium)", + "output": "Ear part described as anatomical orifice, each instance of which is a communication between some scala tympani and scala vestibuli at the apex of some cochlea." + }, + { + "input": "Concept: Segmental atonic seizure (Epilepsy, Partial, Motor)", + "output": "Disease or Syndrome described as a focal seizure characterized at onset by sudden loss or diminution of muscle tone without apparent preceding myoclonic or tonic activity, typically lasting more than 500 ms but less than 2 seconds. It may involve the head, trunk, jaw or limb musculature." + }, + { + "input": "Concept: Hyoscyamus (Plant)", + "output": "something described as a plant genus of the family SOLANACEAE which contains TROPANES." + }, + { + "input": "Concept: phosphotransferase activity, alcohol group as acceptor (transferase activity, transferring phosphorus-containing groups)", + "output": "Molecular Function described as catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." + }, + { + "input": "Concept: Process (Observable entity)", + "output": "something described as a sequence or flow of activities in an organization with the objective of carrying out work. Tasks are atomic activities that are included within a process." + }, + { + "input": "Concept: PKNOWLA (Microbiology procedure)", + "output": "Laboratory Procedure described as a measurement of the Plasmodium knowlesi in an asexual replication stage in a biological specimen." + }, + { + "input": "Concept: BAI2 (Gene or Genome)", + "output": "Gene or Genome described as this gene plays a role in cell adhesion and receptor signaling." + }, + { + "input": "Concept: Nonrenal CL Norm by BMI (Quantitative Concept)", + "output": "Nonrenal Clearance described as the total clearance of a substance from the blood minus the renal clearance divided by the body mass index." + }, + { + "input": "Concept: BPRS01-Tension (BPRS 1988 Version Clinical Classification Question)", + "output": "Intellectual Product described as brief Psychiatric Rating Scale 1988 Version (BPRS 1988 Version) Tension." + }, + { + "input": "Concept: CANP1 (Gene or Genome)", + "output": "something described as human CAPN1 wild-type allele is located in the vicinity of 11q13 and is approximately 31 kb in length. This allele, which encodes calpain-1 catalytic subunit protein, plays a role in limited proteolysis of substrates, which modulates cytoskeletal remodeling and signal transduction." + }, + { + "input": "Concept: PQL12-Take Long Time to Eat (Intellectual Product)", + "output": "PedsQL Neuromuscular Module Acute Version 3.0 Teen Report Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Acute Version 3 Teen - In the past 7 days, how much of a problem has this been for you: I take a long time to eat." + }, + { + "input": "Concept: Ventromedial Hypothalamic Nucleus (Nucleus of hypothalamus)", + "output": "Nucleus of hypothalamus described as a collection of cells located ventrally in the intermediate hypothalamic region. Demonstrated by Nissl stain, it is found in the human, the macaque, the rat and the mouse. It is bounded ventromedially, medially and dorsally by the internuclear area of the periventricular region, which separates it from the arcuate nucleus of the hypothalamus, the intermediate periventricular nucleus and the dorsomedial nucleus of the hypothalamus respectively. Laterally it is bounded for the most part by the lateral hypothalamic area. In some humans ( Saper-2004 ) and in the macaque ( Paxinos-2009a ) it is divided into two parts: the dorsomedial part of the ventromedial nucleus and the ventrolateral part of the ventromedial nucleus. \\r\\nIn the rat ( Swanson-2004 ) and the mouse ( Dong-2004 ) it is divided into four parts. In addition to the dorsomedial and ventrolateral parts, an anterior part of the ventromedial nucleus and a central part of the ventromedial nucleus are distinguished. Functionally it is part of the behavior control column of the subcortical motor system ( Swanson-2004 )." + }, + { + "input": "Concept: Mesenteric Lift (Osteopathic manipulation)", + "output": "Osteopathic manipulation described as technique in which tension is taken off the attachment of the root of the mesentery to the posterior body wall. Simultaneously, the abdominal contents are compressed to enhance venous and lymphatic drainage from the bowel." + }, + { + "input": "Concept: Chlamydial Infection (Sexual Health Issues)", + "output": "Gram-Negative Bacterial Infections described as an infection that is caused by Chlamydia trachomatis." + }, + { + "input": "Concept: Haemophilia Quality of Life Questionnaire for Adults (Clinical or Research Assessment Questionnaire)", + "output": "Clinical or Research Assessment Questionnaire described as a standardized rating scale developed by Mackensen et al in 2005, which is used to measure the physical and emotional impacts on quality of life in adults with hemophilia. The questionnaire contains 46 items which are divided into 10 dimensions: physical health, feelings, self-perception, sports and leisure, work and school, coping, treatment, future, family planning and relationships/partners." + }, + { + "input": "Concept: AVL0213 (Intellectual Product)", + "output": "AVLT-REY Functional Test Question described as the Rey Auditory Verbal Learning TEST (AVLT-REY) List A, Word 13." + }, + { + "input": "Concept: HBNF (PTN gene)", + "output": "PTN gene described as human PTN wild-type allele is located within 12p12.1-p11.2 and is approximately 14 kb in length. This allele, which encodes pleiotrophin protein, plays a role in mitogenesis for endothelial, epithelial, and fibroblast cells and neurite outgrowth. Further, aberrations of the gene result in allelic variants that are implicated in tumor invasion, angiogenesis, and metastasis." + }, + { + "input": "Concept: SMAD5 gene (Transcription factor genes)", + "output": "Gene or Genome described as this gene is involved in signal transduction-mediated transcriptional regulation." + }, + { + "input": "Concept: Glottic Carcinoma pT1 TNM Finding v8 (Finding)", + "output": "Finding described as glottic cancer with tumor limited to the vocal cord(s) (may involve anterior or posterior commissure) with normal mobility." + }, + { + "input": "Concept: Chandler's (PA) syndrome (Rare Non-Neoplastic Disorder)", + "output": "Corneal Diseases described as a grouping of three closely linked conditions: iris nevus (or Cogan-Reese) syndrome, Chandler Syndrome, and essential (progressive) iris atrophy. The most common features of this syndrome are the movement of endothelial cells off the cornea onto the iris leading to corneal swelling, distortion of the iris, and variable degrees of distortion of the pupil. The abnormal cell movement plugs fluid outflow channels of the eye causing GLAUCOMA." + }, + { + "input": "Concept: Adenosarcoma pT3 TNM Finding v7 (Adenosarcoma Pathologic Primary Tumor TNM Finding v7)", + "output": "Finding described as tumor involves abdominal tissues." + }, + { + "input": "Concept: lymphocyte chemotaxis across high endothelial venule (Lymphocyte chemotaxis)", + "output": "Cell Function described as the movement of a lymphocyte to cross a high endothelial venule in response to an external stimulus." + }, + { + "input": "Concept: Part Time Employment (Job details)", + "output": "Job details described as employment involving less than the standard or customary working time." + }, + { + "input": "Concept: Immature Granulocytes in Peripheral Blood Increased (Blast Cells Present in Peripheral Blood)", + "output": "Blast Cells Present in Peripheral Blood described as the presence of an increased number of granulocytic leukocytes, indicating an early-stage response to infection, inflammation, or neoplastic process." + }, + { + "input": "Concept: regulation of embryonic camera-type eye development (regulation of embryonic development)", + "output": "Organism Function described as any process that modulates the frequency, rate or extent of embryonic camera-type eye development." + }, + { + "input": "Concept: Polymorphonuclear Pancreatic Elastase Measurement (Protein or Enzyme Type Measurement)", + "output": "Laboratory Procedure described as the determination of the amount of polymorphonuclear pancreatic elastase present in a sample." + }, + { + "input": "Concept: self help organization (Social support)", + "output": "Social group described as a group of people with similar disease or concerns who help each other cope by sharing experiences and information." + }, + { + "input": "Concept: cooked (Activities of Daily Living)", + "output": "Activities of Daily Living described as the act of preparing something to eat by the application of heat." + }, + { + "input": "Concept: NTX-010 (Oncolytic Viruses)", + "output": "Oncolytic Viruses described as a native, replication-competent oncolytic picornavirus with potential antineoplastic activity. Administered systemically, Seneca Valley virus-001 (SVV-001) specifically targets and infects tumor cells with neuroendocrine characteristics. Upon infection, this agent replicates intracellularly, resulting in tumor cell lysis and reduced tumor cell proliferation. The selective tropism of virus replication may involve receptor-mediated internalization. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C62524\" active clinical trials using this agent." + }, + { + "input": "Concept: RESTING ECG CHANGES (Electrocardiogram finding)", + "output": "Finding described as new or worsening ST or T wave changes on resting ECG (in the absence of confounders, such as LBBB or LVH), defined as either: a) Transient ST elevation (duration less than 20 minutes): new ST elevation at the J point in any two contiguous leads (other than leads V2-V3) of greater than or equal to 0.1 mV. In leads V2-V3, the following cut-points apply: greater than or equal to 0.2 mV in men greater than or equal to 40 years, greater than or equal to 0.25 mV in men less than 40 years, and greater than or equal to 0.15 mV in women, or b) ST depression and T-wave changes: new horizontal or down-sloping ST depression greater than or equal to 0.05 mV in two contiguous leads and/or new T inversion greater than or equal to 0.3 mV in two contiguous leads with prominent R wave or R/S ratio greater than 1." + }, + { + "input": "Concept: up regulation of B cell anergy (regulation of B cell anergy)", + "output": "regulation of B cell anergy described as any process that activates or increases the frequency, rate, or extent of B cell anergy." + }, + { + "input": "Concept: Keratitis fungal (Disease or Syndrome)", + "output": "Mycoses described as keratitis caused by fungi." + }, + { + "input": "Concept: Lips thin (Face)", + "output": "Face described as reduced width of the skin of vermilion border region of upper lip." + }, + { + "input": "Concept: PCN - Percutaneous nephrostomy (Nephrostomy or pyelostomy)", + "output": "Therapeutic or Preventive Procedure described as the insertion of a catheter through the skin and body wall into the kidney pelvis, mainly to provide urine drainage where the ureter is not functional. It is used also to remove or dissolve renal calculi and to diagnose ureteral obstruction." + }, + { + "input": "Concept: Ureteroileostomy, NOS (Repair of ileum)", + "output": "something described as surgical diversion of a ureter into an isolated segment of the ileum which drains through an abdominal stoma." + }, + { + "input": "Concept: Not obtained (Missing Value Reason)", + "output": "something described as not acquired, gained or come to the possession." + }, + { + "input": "Concept: Carcinoma of the Conjunctiva Clinical TNM Finding v7 (Carcinoma of the Conjunctiva TNM Finding v7)", + "output": "Carcinoma of the Conjunctiva TNM Finding v7 described as a clinical finding about one or more characteristics of carcinoma of the conjunctiva, following the rules of the TNM AJCC v7 classification system. The assessment of cancer is based on inspection, slit-lamp examination, and palpation of the regional lymph nodes. All conjunctival surfaces are inspected and photographed with eversion of the upper eyelid. High-frequency ultrasound (UBM) imaging should be performed when the tumor is found to be affixed to the globe and when intraocular invasion is suspected. Low-frequency ultrasound may also be used to evaluate the sclera, eye, and orbit." + }, + { + "input": "Concept: (4R,5S,6S)-6-((1r)-1-Hydroxyethyl)-4-Methyl-3-((4-((5S)-5-Methyl-2,5-Dihydro-1H-Pyrrol-3-yl)Thiazol-2-yl)Sulfanyl)-7-Oxo-1-Azabicyclo(3.2.0)Hept-2-Ene-2-Carboxylic Acid (Antibiotics)", + "output": "Monobactams described as a broad-spectrum carbapenem with activity against gram-positive bacteria, including methicillin-resistant S. aureus." + }, + { + "input": "Concept: arachidonoylethanolamide epoxidase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)", + "output": "something described as catalysis of the epoxidation of double bonds of the arachidonoyl moiety of anandamide." + }, + { + "input": "Concept: replacement (removal technique)", + "output": "Functional Concept described as the act of removing one thing and putting another thing in its place." + }, + { + "input": "Concept: hepoxilin formation (unsaturated fatty acid biosynthetic process)", + "output": "long-chain fatty acid biosynthetic process described as the chemical reactions and pathways resulting in the formation of hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology." + }, + { + "input": "Concept: Acantholyses (Dermal and epidermal conditions NEC)", + "output": "Skin Histology described as the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes." + }, + { + "input": "Concept: Jaw Clicking or Popping (Finding of head and neck region)", + "output": "Finding of head and neck region described as noise in the temporomandibular joint, with or without pain, when fully opening the jaw." + }, + { + "input": "Concept: 1p31.3-p31.2 (Chromosome band)", + "output": "something described as a chromosome band present on 1p" + }, + { + "input": "Concept: stage IVA bladder cancer AJCC v8 (Neoplastic Process)", + "output": "Bladder cancer stage IV described as stage IVA includes: (T4b, N0, M0); (Any T, Any N, M1a). T4b: Extravesical tumor invades pelvic wall, abdominal wall. N0: No regional lymph node metastasis. M0: No distant metastasis. M1a: Distant metastasis limited to lymph nodes beyond the common iliacs." + }, + { + "input": "Concept: a.pulmonalis; atresia (Congenital atresia of artery)", + "output": "Congenital malformation of the great arteries described as a congenital anomaly with a narrowing or complete absence of the opening between the right ventricle and the pulmonary artery." + }, + { + "input": "Concept: mitochondrial inner membrane protein import (Cell Function)", + "output": "inner mitochondrial membrane organization described as the processes mediating the insertion of proteins into the mitochondrial inner membrane. Mitochondrial inner membrane proteins can get inserted from the cytosol, by crossing the outer membrane and being guided by an inner membrane translocase complex into their final destination in the inner membrane. Some proteins present in the intermembrane space can get inserted into the inner mitochondrial membrane. Finally, some proteins are inserted into the inner membrane from the matrix side of the membrane." + }, + { + "input": "Concept: Fatigable weakness of distal limb muscles (Finding)", + "output": "Finding described as a type of weakness of a skeletal muscle of distal part of a limb that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions." + }, + { + "input": "Concept: Graph Combinatorial Layout (Graph Layout)", + "output": "Graph Layout described as a type of graph similar to a radial layout, but compressed to fit rapidly-branching networks." + }, + { + "input": "Concept: lung (Structure of organ in respiratory system)", + "output": "Set of organs described as one of a pair of organs in the chest that supplies the body with oxygen, and removes carbon dioxide from the body." + }, + { + "input": "Concept: uncinate process pancreas (Region of pancreas)", + "output": "Stem of Organ described as a portion of the pancreas that extends behind the superior mesenteric artery and superior mesenteric vein." + }, + { + "input": "Concept: Sinciput Presentation (Fetal presentation finding)", + "output": "Finding described as a fetal position during delivery in which the frontal part of the skull including forehead and the top of the head is first to descend into the birth canal." + }, + { + "input": "Concept: NEOPL CERVICAL INTRAEPITHELIAL (Precancerous Conditions)", + "output": "Precancerous Conditions described as growth of abnormal cells on the surface of the cervix. Numbers from 1 to 3 may be used to describe how abnormal the cells are and how much of the cervical tissue is involved." + }, + { + "input": "Concept: psychobiology (Biomedical Occupation or Discipline)", + "output": "something described as the study of the interrelationships of the biology and psychology in cognitive functioning, including intellectual, memory, and related neurocognitive processes." + }, + { + "input": "Concept: Mammalian Glycan (Organic Chemical)", + "output": "Organic Chemical described as an oligosaccharide protein modification that is synthesized by mammalian cells." + }, + { + "input": "Concept: Cerebral aneurysm NOS (Disease or Syndrome)", + "output": "something described as a balloon type pouch or bulge in the wall of a cerebral blood vessel." + }, + { + "input": "Concept: intraciliary transport involved in cilium assembly (intraciliary transport)", + "output": "something described as the bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly." + }, + { + "input": "Concept: BCR/ABL1 Fusion Protein with ABL1 NP 005148.2:p.Glu255Lys (Fusion Proteins, bcr-abl)", + "output": "Amino Acid, Peptide, or Protein described as a fusion protein encoded by the BCR/ABL1 fusion gene with ABL1 NM_005157.4:c.763G>A mutation. This protein is comprised of the N-terminus of the breakpoint cluster region protein fused to almost the entire tyrosine-protein kinase ABL1 protein where the glutamic acid at position 255 of the ABL1 protein has been replaced by lysine." + }, + { + "input": "Concept: PODCI Pediatric Parent-Reported Version - Lift Heavy Books (Intellectual Product)", + "output": "something described as pediatric Outcomes Data Collection Instrument, Pediatric Parent-Reported Version (PODCI Pediatric Parent-Reported Version) During the last week, was it easy or hard for your child to: Lift heavy books?" + }, + { + "input": "Concept: Walls (Domestic structure)", + "output": "Conceptual Entity described as a layer of material that encloses space or that encloses a structure." + }, + { + "input": "Concept: NPH Insulin, Human (I [Preparations])", + "output": "insulin isophane described as human isophane insulin that is used to manage BLOOD GLUCOSE levels in patients with DIABETES." + }, + { + "input": "Concept: CA125-II (Immunologic Tests)", + "output": "Laboratory Procedure described as a second generation radioimmunoassay to measure serum levels of CA-125." + }, + { + "input": "Concept: G Protein Pathway Suppressor 2 Protein (Regulatory Protein)", + "output": "Amino Acid, Peptide, or Protein described as g protein pathway suppressor 2 (327 aa, ~37 kDa) is encoded by the human GPS2 gene. This protein is involved in the regulation of G-protein and mitogen-activated protein kinase-mediated signal pathways." + }, + { + "input": "Concept: CSF - Cerebrospinal rhinorrho (Headache Disorders)", + "output": "Ear finding described as discharge of cerebrospinal fluid through the nose." + }, + { + "input": "Concept: Pulmonaria officinalis / lungwort (Pulmonaria)", + "output": "Plant described as lungwort." + }, + { + "input": "Concept: Lung Parenchyma Tumor Location (Finding)", + "output": "something described as a section header to choose the location of the parenchyma in the lung." + }, + { + "input": "Concept: University of New Mexico Cancer Center (Professional or Occupational Group)", + "output": "Professional or Occupational Group described as the mission of the University of New Mexico Cancer Center is to reduce the burden of cancer incidence and mortality by discovering the genetic, environmental, social, and behavioral factors that contribute to the distinct cancer patterns and disparities in the American Southwest; translate its scientific discoveries to novel diagnostic, screening, prevention, and therapeutic tools and clinical trials; and assure that all New Mexicans have access to outstanding cancer treatment and clinical trials. It became an NCI-designated cancer center in 2005. It is a University of New Mexico center." + }, + { + "input": "Concept: C/EBP-Alpha bZIP Domain Mutation (Cell or Molecular Dysfunction)", + "output": "Cell or Molecular Dysfunction described as a change in the nucleotide sequence of the CEBPA gene that alters the amino acid sequence of the DNA-binding basic leucine zipper domain of CCAAT/enhancer binding protein alpha." + }, + { + "input": "Concept: recombinant consensus interferon alpha (Amino Acid, Peptide, or Protein)", + "output": "I [Preparations] described as an analogue of consensus interferon which contains an additional methionyl amino acid residue. Consensus interferon (also known as interferon alfacon-1, rCon-IFN, and CIFN) is a genetically engineered synthetic interferon created from the most common amino acid sequences from the naturally occurring alpha interferons. Alpha interferons bind to specific cell-surface receptors, resulting in the transcription and translation of genes whose protein products have antiviral, antiproliferative, anticancer, and immune-modulating effects. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1766\" active clinical trials using this agent." + }, + { + "input": "Concept: determination of muscle attachment site (Intercellular Communication Process)", + "output": "something described as the process that mediates the transfer of information from the cells of a muscle to those of its intended target, thereby identifying the target site." + }, + { + "input": "Concept: Electronic Nicotine Delivery Systems (Smoking Devices)", + "output": "something described as devices or objects designed to provide NICOTINE in the form of an inhaled aerosol." + }, + { + "input": "Concept: SUPPEC (Intellectual Product)", + "output": "Intellectual Product described as a dataset used to represent non-standard variables and their association to parent records in the Exposure as Collected domain." + }, + { + "input": "Concept: Organ component gland (Thesaurus of Psychological Index Terms)", + "output": "Body Part, Organ, or Organ Component described as an organ that makes one or more substances, such as hormones, digestive juices, sweat, tears, saliva, or milk. Endocrine glands release the substances directly into the bloodstream. Exocrine glands release the substances into a duct or opening to the inside or outside of the body." + }, + { + "input": "Concept: Intraperitoneal (Finding)", + "output": "something described as an intended site for a dose form that is for administration into the peritoneal cavity." + }, + { + "input": "Concept: Non-human Clinical Subject Data Section (Document type)", + "output": "Intellectual Product described as a section within the study document pertaining to data collected from non-human clinical study subjects." + }, + { + "input": "Concept: bunolol (Phenoxypropanolamines)", + "output": "Tetrahydronaphthalenes described as a nonselective beta-adrenoceptor antagonist used in the treatment of glaucoma." + }, + { + "input": "Concept: balloon catheter radiation (Therapeutic or Preventive Procedure)", + "output": "Brachytherapy described as a system used to deliver internal radiation therapy to breast cancer patients after surgery to remove their cancer. MammoSite targets only the part of the breast where the cancer was found. After a patient has had a lumpectomy to remove the cancer, a small balloon on the end of a catheter (thin tube) is inserted into the empty space left by the surgery. The balloon is then filled with liquid and left in place. Using the catheter, radioactive seeds are put into the balloon twice a day for five days and removed each time. Once treatment has ended, the catheter and balloon are removed. MammoSite is a type of intracavitary brachytherapy and partial breast irradiation therapy (PBRT)." + }, + { + "input": "Concept: peripheral tolerance induction to self antigen (tolerance induction to self antigen)", + "output": "peripheral tolerance induction described as tolerance induction to self antigens in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." + }, + { + "input": "Concept: carbenoxolone (Gastrointestinal Agents)", + "output": "Terpenes described as an agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise the drug is low in toxicity." + }, + { + "input": "Concept: glipizide (Sulfonylurea Compounds)", + "output": "Sulfonylureas for blood glucose lowering described as an oral hypoglycemic agent which is rapidly absorbed and completely metabolized." + }, + { + "input": "Concept: TGM2 IgG Measurement (Laboratory Procedure)", + "output": "Laboratory Procedure described as the determination of the amount of tissue transglutaminase IgG antibody present in a sample." + }, + { + "input": "Concept: Merkel Cell Carcinoma pN0 TNM Finding v8 (Finding)", + "output": "Merkel Cell Carcinoma Pathologic Regional Lymph Nodes TNM Finding v8 described as merkel cell carcinoma without regional lymph node metastasis detected on pathologic examination." + }, + { + "input": "Concept: Semen Quality (Laboratory Procedure)", + "output": "something described as measurable parameters of semen related to male fertility (e.g., SPERM COUNT; SPERM MOTILITY, volume, concentration, morphology, and viability)." + }, + { + "input": "Concept: ESRS-A - Dystonia: Trunk/Neck (Intellectual Product)", + "output": "Intellectual Product described as extrapyramidal Symptom Rating Scale-Abbreviated (ESRS-A) Dystonia: Trunk, neck." + }, + { + "input": "Concept: Exhaust Hoods, Food Service (Manufactured Object)", + "output": "Manufactured Object described as devices containing a mechanical fan that hang above food service ranges, steam equipment, or dishwashers or that are freestanding units. They remove airborne grease, combustion products, fumes, smoke, odors, heat, and/or steam from the air by evacuation of the air and filtration. Exhaust hoods are often used in combination with fire suppression devices so that fumes from a grease fire are properly vented and the fire is put out quickly. Commercial exhaust hoods may also be combined with a fresh air fan that draws in exterior air, circulating it with the cooking fumes, which is then drawn out by the hood. In most exhaust hoods, a filtration system removes grease (grease trap) and other particles. Although many vent hoods exhaust air to the outside, some recirculate the air to the kitchen and include a filter to remove odors in addition to the grease." + }, + { + "input": "Concept: 2,3-dihydroxybenzoic acid decarboxylase activity (carboxy-lyase activity)", + "output": "Molecular Function described as catalysis of the reaction: 2,3-dihydroxybenzoate + H(+) = catechol + CO(2)." + }, + { + "input": "Concept: encapsulation of foreign target (immune effector process)", + "output": "immune effector process described as events resulting in the formation of a multilayered cellular sheath surrounding an invader and thus preventing its development. This defense mechanism is often seen in insects in response to nematodes or parasitoids, which are too large to be phagocytosed by individual hemocytes. In some organisms the capsule is blackened due to melanization." + }, + { + "input": "Concept: DRRI-2 - M: Had Major Conflict With Family (Intellectual Product)", + "output": "Intellectual Product described as deployment Risk & Resilience Inventory-2 - During deployment: I had a major conflict with a family member or other loved one." + }, + { + "input": "Concept: Urethral Cancer Pathologic Distant Metastasis TNM Finding v7 (Urethral Cancer Pathologic TNM Finding v7)", + "output": "something described as a pathologic finding about one or more characteristics of urethral cancer, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. There is no pathologic M0 for urethral cancer." + }, + { + "input": "Concept: Clostridium colitis (Intestinal infectious disease)", + "output": "Clostridium Infections described as an acute inflammatory disorder of the colon secondary to infection with any species of the bacterial genus Clostridium. Symptoms include acute diarrhea, abdominal pain, and myalgia." + }, + { + "input": "Concept: SpecimenCollectionProtocol (Intellectual Product)", + "output": "Process Protocol described as a set of procedures that govern the collection of biospecimens. EXAMPLE(S): OTHER NAME(S): NOTE(S):" + }, + { + "input": "Concept: 7: 150409988-150373707 (Chromosome 7 Physical Location)", + "output": "Spatial Concept described as physical location of SMARCD3_Gene" + }, + { + "input": "Concept: CDRS1-Excessive Guilt (Intellectual Product)", + "output": "Intellectual Product described as children's Depression Rating Scale, Revised (CDRS-R) Excessive guilt." + }, + { + "input": "Concept: Anorectal Catheters (Gastrointestinal catheter)", + "output": "Gastrointestinal catheter described as catheters designed to be introduced into the rectum; some of them are long enough to be advanced and have their distal tip located in the proximal portion of the colon. These catheters are usually made of rubber or silicone rubber. Most rectal catheters are used for rectal injections; for the purpose of clearing out the bowel; for administration of drugs, contrast media, or food; or for manometric measurements. Some of these catheters are also used in the management of continent ileostomy." + }, + { + "input": "Concept: Radionuclide Total Dose (Dosage)", + "output": "something described as total amount of radionuclide administered to the patient at Radiopharmaceutical Start Time." + }, + { + "input": "Concept: Inferior papillary muscle of right ventricle (Myocardium and Cardiac Conduction System)", + "output": "Myocardium and Cardiac Conduction System described as papillary muscle of right ventricle which is attached to the wall of right ventricle below the posteroseptal commissure of tricuspid valve." + }, + { + "input": "Concept: No Difficulty (Finding)", + "output": "Clinical or Research Assessment Answer described as a response indicating that an individual is able to do something without any difficulty." + }, + { + "input": "Concept: rhamnetin 4'-O-methyltransferase activity (methyltransferase activity)", + "output": "methyltransferase activity described as catalysis of the reaction: rhamnetin + S-adenosyl-L-methionine <=> ombuin + S-adenosyl-L-homocysteine + H+." + }, + { + "input": "Concept: upregulation of artery morphogenesis (Organ or Tissue Function)", + "output": "Organ or Tissue Function described as any process that activates or increases the frequency, rate or extent of artery morphogenesis." + }, + { + "input": "Concept: Pentagon (Structured Product Labeling Shape)", + "output": "Qualitative Concept described as a five-sided polygon." + }, + { + "input": "Concept: Lysozyme Immunohistochemistry (Immunohistochemistry)", + "output": "Immunohistochemistry described as an immunohistochemical diagnostic test utilizing an antibody to detect lysozyme in tissues." + }, + { + "input": "Concept: Bolts, Bone (Internal Fixators)", + "output": "something described as bolts designed to be inserted through the hole created in a bone and then secured by nuts and washers. These bolts typically consist of metallic or plastic pins or rods that are either threaded at one end with a head at the other end or threaded at both ends; bone bolts are usually supplied with washers for both ends and one or two nuts. Bone bolts are used mainly for direct compression reduction and/or fixation of the proximal end of the tibia or ulna after fractures; dedicated bolts are used to lock to the bone long intramedullary nails used for tibia and femoral fractures." + }, + { + "input": "Concept: Grade 1 Hallucinations (Finding)", + "output": "Hallucinations, CTCAE described as mild hallucinations" + }, + { + "input": "Concept: 2',3',5'-Triacetyluridine (Pyrimidine Nucleotides)", + "output": "Nucleosides described as a substance that is being studied for its ability to protect against the gastrointestinal side effects caused by fluorouracil. It belongs to the family of drugs called cytoprotective agents." + }, + { + "input": "Concept: Grade 4 Splenic Infection, CTCAE (Finding)", + "output": "Splenic Infection, CTCAE described as life-threatening consequences; urgent intervention indicated" + }, + { + "input": "Concept: SGPT - glutamate pyruvate transaminase (Transaminases)", + "output": "something described as an enzyme found in the liver and other tissues. A high level of serum glutamate pyruvate transaminase released into the blood may be a sign of liver damage, cancer, or other diseases." + }, + { + "input": "Concept: Tegmentums, Midbrain (Segment of midbrain)", + "output": "Neuroanatomy described as subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle." + }, + { + "input": "Concept: Type I Renal Tubular Acidosis (Disease or Syndrome)", + "output": "Renal tubular acidosis described as impairment in renal collecting tubule acid secretion that results in a hypokalemic hyperchloremic metabolic acidosis." + }, + { + "input": "Concept: Impostor (Deception)", + "output": "Crime Act described as exploitation through misrepresentation of the facts or concealment of the purposes of the exploiter." + }, + { + "input": "Concept: HEMATOL (Medicine)", + "output": "Internal medicine specialty described as the branch of medicine that deals with the blood and blood-forming organs and the diseases thereof." + }, + { + "input": "Concept: Detachment of nail plate (Examination of nail)", + "output": "Nail plate described as a nail condition characterized by spontaneous separation of a fingernail or toenail from its nail bed." + }, + { + "input": "Concept: Flared outermost metaphysis of shankbone (Flared lower limb metaphysis)", + "output": "Flared lower limb metaphysis described as the presence of a splayed (i.e.,flared) metaphyseal segment of the distal tibia." + }, + { + "input": "Concept: Electrophoresis, agarose gel method (Gel Electrophoresis)", + "output": "Electrophoresis described as electrophoresis in which agar or agarose gel is used as the diffusion medium." + }, + { + "input": "Concept: MSH - gamma melanocyte stimulating hormone (Melanocyte stimulating hormone)", + "output": "Pharmacologic Substance described as an 11-amino acid peptide derived from the N-terminal fragment of pro-opiomelanocortin (POMC). Gamma-MSH stimulates adrenal steroidogenesis and has an regulatory role in the cardiovascular and the renal systems." + }, + { + "input": "Concept: RFG5 (Gene or Genome)", + "output": "Gene or Genome described as human GOLGA5 wild-type allele is located within 14q and is approximately 45 kb in length. This allele, which encodes golgin subfamily A member 5 protein, plays a role in Golgi structure formation. Both mutation of the gene and a chromosomal translocation t(10;14)(q11;q32) of this gene and the RET gene are associated with thyroid papillary carcinoma." + }, + { + "input": "Concept: Genital Mutilation, Female (Clitoridotomy)", + "output": "Female Genital Diseases described as caused by all procedures involving partial or total removal of the external female genitalia or other injury to the female genital organs for non-medical reasons." + }, + { + "input": "Concept: porphyromonas asaccharolytica (Bacterium)", + "output": "something described as any bacterial organism that can be assigned to the species Porphyromonas asaccharolytica." + }, + { + "input": "Concept: Couinaud Segment VI (Body Part, Organ, or Organ Component)", + "output": "Couinaud liver segment described as couinaud segment VI, corresponding to the posterior segment of the right lobe of the liver, located inferiorly." + }, + { + "input": "Concept: Camptothecin Polyglutamate (Topoisomerase I Inhibitors)", + "output": "Topoisomerase I Inhibitors described as a form of the anticancer drug camptothecin that may have fewer side effects and work better than camptothecin. It is being studied in the treatment of cancer. It is a type of DNA topoisomerase inhibitor." + }, + { + "input": "Concept: positive regulation of behavioural response to food (positive regulation of behavior)", + "output": "positive regulation of behavior described as any process that activates or increases the frequency, rate or extent of feeding behavior." + }, + { + "input": "Concept: 5q32-33.1 (Chromosome band)", + "output": "something described as a chromosome band present on 5q" + }, + { + "input": "Concept: LEC01-Physical Assault: Not Apply (LEC-5 Standard Version Questionnaire Question)", + "output": "LEC-5 Standard Version Questionnaire Question described as life Events Checklist for DSM-5 Standard Version (LEC-5 Standard Version) Physical assault (for example, being attacked, hit, slapped, kicked, beaten up): Doesn't apply." + }, + { + "input": "Concept: fluconazole transport (Drug Transport Process)", + "output": "something described as the directed movement of fluconazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections." + }, + { + "input": "Concept: FACT-LYM Version 4 - Trouble Meeting Needs of Family (FACT-LYM Version 4 Questionnaire Question)", + "output": "Intellectual Product described as functional Assessment of Cancer Therapy-Lymphoma Version 4 - Physical Well-Being: Because of my physical condition, I have trouble meeting the needs of my family." + }, + { + "input": "Concept: 2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide (Thiazines)", + "output": "Nitrogen and nitrogen compound described as a nonsteroidal oxicam derivative with anti-inflammatory, antipyretic and analgesic properties. As a non-selective, nonsteroidal anti-inflammatory drug (NSAID), piroxicam binds and chelates both isoforms of cyclooxygenases (COX1 and COX2), thereby stalling phospholipase A2 activity and conversion of arachidonic acid into prostaglandin precursors at the rate limiting cyclooxygenase enzyme step. This results in inhibition of prostaglandin biosynthesis. As a second, independent effect, piroxicam inhibits the activation of neutrophils thereby contributing to its overall anti-inflammatory effects. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C751\" active clinical trials using this agent." + }, + { + "input": "Concept: Periarthritides (DISORDERS OF THE SYNOVIA, TENDONS AND BURSAE INCLUDING ENTHESOPATHIES)", + "output": "Soft tissue rheumatism described as inflammation of the tissues around a joint." + }, + { + "input": "Concept: Adenosarcoma Clinical Distant Metastasis TNM Finding v7 (Adenosarcoma Clinical TNM Finding v7)", + "output": "Adenosarcoma Clinical TNM Finding v7 described as a clinical finding about one or more characteristics of adenosarcoma, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases." + }, + { + "input": "Concept: cell proliferation involved in compound eye morphogenesis (cell population proliferation)", + "output": "cell population proliferation described as the multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis." + }, + { + "input": "Concept: ADCS-ADL MCI - Talk About Current Events (Intellectual Product)", + "output": "Intellectual Product described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, MCI Version - In the past 4 weeks, did {S} talk about current events?" + }, + { + "input": "Concept: DNA Topoisomerase II, Alpha Isozyme Protein Variant (Gene Product Sequence Variation)", + "output": "Cell or Molecular Dysfunction described as a variation in the amino acid sequence for the DNA topoisomerase 2-alpha protein." + }, + { + "input": "Concept: Healthcare Activity (Clinical or Research Activity)", + "output": "LIST OF PHARMACEUTICAL COMPANIES described as the actions of prevention, treatment, and management of illness and the preservation of mental and physical well-being through the services offered by the medical and allied health professions." + }, + { + "input": "Concept: Non-specified HCPCS II magnetic or non-magnetic imaging or radiation therapy service reference code no charge (Tracking code use with or without ICD diagnosis)", + "output": "Tracking code use with or without ICD diagnosis described as mapping the practitioner type or specialty to a magnetic or non-magnetic imaging or radiation therapy service code. Use associated HCPCS II codes to bill for imaging or radiation therapy service(s). This code is used for scope-of-practice mapping, not for billing." + }, + { + "input": "Concept: FACT-Taxane Version 4 - I Feel Nervous (Intellectual Product)", + "output": "FACT-Taxane Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Taxane Version 4 - Emotional Well-Being: I feel nervous." + }, + { + "input": "Concept: mediterranean diets (Diet therapy)", + "output": "Diet described as a diet typical of the Mediterranean region characterized by a pattern high in fruits and vegetables, EDIBLE GRAIN and bread, potatoes, poultry, beans, nuts, olive oil and fish while low in red meat and dairy and moderate in alcohol consumption." + }, + { + "input": "Concept: Not Known if TP53 Mutation Analysis Was Performed (Finding)", + "output": "something described as an indication that it is not known whether TP53 mutation analysis was performed during the study." + }, + { + "input": "Concept: measles, live attenuated (Cancer Vaccines)", + "output": "something described as a live, attenuated measles vaccine with potential antineoplastic activity. Upon subcutaneous administration, live attenuated measles virus vaccine may activate the immune system to mount a cytotoxic T-lymphocyte (CTL) response against measles-positive tumor cells. Measles virus has been shown to be present in some non-small cell lung cancers." + }, + { + "input": "Concept: heterozygous genotype (Genotype types)", + "output": "Zygosity described as an individual having different alleles at one or more loci regarding a specific character." + }, + { + "input": "Concept: salivary calculi (Pathologic Function)", + "output": "Calculi described as the presence of calculi in a salivary duct or gland." + }, + { + "input": "Concept: CKD-EPI CREATININE-CYSTATIN C FORMULA (Intellectual Product)", + "output": "something described as a formula to estimate glomerular filtration rate that takes into account sex, age, race, serum creatinine (SCr) and serum cystatin C (Scys). eGFR(mL/min/1.73 m2)=135 x min(SCr/k, 1)a x max(SCr/k, 1)-0.601 x min(Scys/0.8, 1)-0.375 x max(Scys/0.8, 1)-0.711 x 0.995^Age x 0.969 [if female] x 1.08 [if black]. (Inker LA, Schmid CH, Tighiouart H, et al. Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med. 2012;367(1):20-29.)" + }, + { + "input": "Concept: Central heterochromia (Heterochromia iridis)", + "output": "Sign or Symptom described as the presence of distinct colors in the central (pupillary) zone of the iris than in the mid-peripheral (ciliary) zone." + }, + { + "input": "Concept: arabinogalactan protein metabolic process (Molecular Function)", + "output": "Molecular Function described as the chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein, which is composed of a group of core protein of highly varying length and domain complexity. These are O-glycosylated at one or more hydroxyproline residues by arabinogalactan (AG) type II groups, which consist of (1->3)-beta-galactan and (1->6)-beta-linked galactan chains connected to each other by (1->3,1->6)-linked branch points, O-3 and O-6 positions substituted with terminal arabinosyl residues. Also, rhamnose, fucose, glucuronic and galacturonic acid can be present in the glycan structures." + }, + { + "input": "Concept: Sinonasal Adenocarcinoma, Intestinal-Type with Solid Pattern (Sinonasal Adenocarcinoma, Intestinal-Type)", + "output": "Sinonasal Adenocarcinoma, Intestinal-Type described as an intestinal-type adenocarcinoma that arises from the sinonasal tract. It is characterized by the presence of a solid growth pattern." + }, + { + "input": "Concept: Autonomy, Personal (Principle-Based Ethics)", + "output": "Idea or Concept described as self-directing freedom and especially moral independence. An ethical principle holds that the autonomy of persons ought to be respected." + }, + { + "input": "Concept: agitates (Tissue Perfusion: Cellular)", + "output": "Neurological signs and symptoms NEC described as a state of exceeding restlessness and excessive motor activity associated with mental distress or a feeling of inner tension." + }, + { + "input": "Concept: Ventral white column of spinal cord (spinal white matter)", + "output": "Spinal cord, roots and ganglia structure described as ventral portion of the white matter of the spinal cord; primarily contains axons descending from the brain that controls axial musculature." + }, + { + "input": "Concept: interstitial nucleus of vestibular nerve (Nucleus of brain)", + "output": "Nucleus of brain described as clusters of large nerve cells distributed in the vestibular component of vestibulocochlear nerve fibers in the human and the macaque ( Paxinos-2004 ), and the rat ( Swanson-2004 ). They are revealed in Nissl stained sections and stain for acetylcholinesterase. Functionally they belong to the vestibulomotor regions of the behavioral control column ( Swanson-2004 )." + }, + { + "input": "Concept: S100 A8 Protein (Amino Acid, Peptide, or Protein)", + "output": "something described as a 10.8-kDa member of the S-100 family of calcium-binding proteins that can form homo- or heterocomplexes with CALGRANULIN B and a variety of other proteins. The calgranulin A/B heterodimer is known as LEUKOCYTE L1 ANTIGEN COMPLEX. Calgranulin A is found in many cell types including GRANULOCYTES; KERATINOCYTES; and myelomonocytes, and has been shown to act as a chemotactic substance for NEUTROPHILS. Because it is present in acute inflammation but absent in chronic inflammation, it is a useful biological marker for a number of pathological conditions." + }, + { + "input": "Concept: Model - style/design (Conceptual Entity)", + "output": "Conceptual Entity described as a style or design of an item." + }, + { + "input": "Concept: EPIC-CP Questionnaire Question (Clinical or Research Assessment Question)", + "output": "Clinical or Research Assessment Question described as a question associated with the EPIC-CP questionnaire." + }, + { + "input": "Concept: Curved innermost pinkie toe bone (Curved proximal toe phalanx)", + "output": "Curved 5th toe phalanx described as a deviation from the normal straight form of the proximal phalanx of the fifth toe." + }, + { + "input": "Concept: T-Cell Lymphoma of Skin Stage IV (stage, cutaneous T-cell non-Hodgkin lymphoma)", + "output": "something described as stage IV cutaneous T-cell lymphoma may be either of the following: in stage IVA cancer, the skin is red, dry, and scaly, and the lymph nodes contain cancer cells; in stage IVB cancer, the skin is red, dry and scaly, cancer cells may be found in lymph nodes, and cancer has spread to other organs in the body." + }, + { + "input": "Concept: ostomy irrigation asistnce (Therapeutic or Preventive Procedure)", + "output": "Common nursing interventions described as assisting a patient in flushing or washing out his or her ostomy." + }, + { + "input": "Concept: PANTOGRAPH (Medical Device)", + "output": "Medical Device described as a pantograph is a device intended to be attached to a patient's head to duplicate lower jaw movements to aid in construction of restorative and prosthetic dental devices. A marking pen is attached to the lower jaw component of the device and, as the patient's mouth opens, the pen records on graph paper the angle between the upper and the lower jaw." + }, + { + "input": "Concept: CHAK2 (Gene or Genome)", + "output": "something described as human TRPM6 wild-type allele is located in the vicinity of 9q21.13 and is approximately 166 kb in length. This allele, which encodes transient receptor potential cation channel subfamily M member 6 protein, is involved in both magnesium homeostasis and protein phosphorylation. Mutation of the gene is associated with hypomagnesemia." + }, + { + "input": "Concept: ADL03-Extenuating Circumstances (Intellectual Product)", + "output": "ADCS-ADL MCI Questionnaire Question described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, MCI (ADCS-ADL MCI) Has an extenuating circumstance (such as a physical health problem, change in residence, change in support network, death of a family member, etc.) contributed to a recent alteration in the subject's activities of daily living?" + }, + { + "input": "Concept: gangliocytomas (neoplasm of autonomic nervous system)", + "output": "Benign Neoplasm described as a benign neuroblastic tumor of the sympathetic nervous system that occurs in childhood. Ganglioneuroma typically arises from the sympathetic trunk in the mediastinum. Histologic features include spindle cell proliferation (resembling a neurofibroma) and the presence of large ganglion cells. Common presenting features include a palpable abdominal mass, hepatomegaly, and a thoracic mass detected on routine chest X-ray." + }, + { + "input": "Concept: Notophthalmus (Pleurodelinae)", + "output": "Amphibian described as a genus of newts of the Salamandridae family found in North America in areas east of the 100th meridian. A common species is NOTOPHTHALMUS VIRIDESCENS." + }, + { + "input": "Concept: negative regulation of aeciospore formation (negative regulation of asexual sporulation resulting in formation of a cellular spore)", + "output": "negative regulation of asexual sporulation resulting in formation of a cellular spore described as any process that stops, prevents, or reduces the frequency, rate or extent of aeciospore formation, a process in which a dikaryotic spore of typically a rust fungus is produced in an aecium." + }, + { + "input": "Concept: Clinical Stage IA Cutaneous Melanoma AJCC v8 (Clinical Stage I Cutaneous Melanoma AJCC v8)", + "output": "something described as stage IA includes: T1a, N0, M0. T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. N0: No regional lymph node metastasis detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable." + }, + { + "input": "Concept: SLIFE (Finding)", + "output": "Finding described as a situation that imperils the existence of an entity." + }, + { + "input": "Concept: Lactose, Unspecified form (Sugars/Sugar metabolism)", + "output": "Drug pseudoallergen described as a disaccharide of GLUCOSE and GALACTOSE in human and cow milk. It is used in pharmacy for tablets, in medicine as a nutrient, and in industry." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Hematology, Fibrinolysis, Plasminogen Activator (Medical Device)", + "output": "something described as hematology reagents intended to perform qualitative and/or quantitative analyses on a sample of body fluids to determine plasminogen activators, a group of substances that convert plasminogen into plasmin. Plasminogen activators may be present in blood, vascular endothelium and other tissues, urine, and/or other body fluids. Several of these activators have therapeutic use in the treatment of thrombosis." + }, + { + "input": "Concept: INR (Passive Method)", + "output": "Osteopathic Combined Method described as a treatment system in which combined procedures are designed to stretch and reflexly release patterned soft tissue and joint-related restrictions. Both direct and indirect methods are used interactively." + }, + { + "input": "Concept: Dental care (regime/therapy)(procedure) (Medical & Physical Treatment)", + "output": "Dentistry described as any of the dental diagnostic, preventive, and restorative services provided to meet the needs of a patient." + }, + { + "input": "Concept: 2-oxoglutarate-dependent DNA demethylase (DNA demethylase activity)", + "output": "oxidoreductase activity described as catalysis of the removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms." + }, + { + "input": "Concept: Rheumatoid Factor IgA Antibody (Laboratory Procedure)", + "output": "something described as the determination of the rheumatoid factor antibody IgA present in a sample." + }, + { + "input": "Concept: Acute emergence over days (acute)", + "output": "acute described as acute appearance of disease manifestations in a period of days. []" + }, + { + "input": "Concept: membrane region (Membrane)", + "output": "something described as a membrane that is a part of a larger membrane. Examples include the apical region of the plasma membrane of an epithelial cell and the various regions of the endoplasmic reticulum membrane." + }, + { + "input": "Concept: Vaginal pruritus (Disorder of soft tissue of body cavity)", + "output": "Abnormal vagina morphology described as itching of the skin of the vagina, vulva, and surrounding area." + }, + { + "input": "Concept: cysteine-S-conjugate N-malonyl transferase activity (transferase activity, transferring acyl groups other than amino-acyl groups)", + "output": "Molecular Function described as catalysis of the reaction: malonyl-CoA(5-) + an L-cysteine-S-conjugate <=> coenzyme A + H+ + an N-malonyl-L-cysteine-S-conjugate." + }, + { + "input": "Concept: Viruses, MERS (Betacoronavirus)", + "output": "Virus described as a coronavirus first reported in the summer of 2012 in a pneumonia patient in SAUDI ARABIA. It is related to SARS VIRUS. MERS-CoV has an estimated incubation period of 12 days and symptoms include renal failure and severe acute pneumonia with often fatal outcome." + }, + { + "input": "Concept: Cuffs, Pneumatic (Medical Device)", + "output": "something described as inflatable cuffs designed to exert a pressure on the circumference of an extremity by means of a compressed gas. These devices typically include a bladder within the cuff that is inflated through tubes that run from the bladder connectors to the source of compressed air located in a tourniquet, circulatory assist unit, automated sphygmomanometer or other device. The cuff is fastened to the extremity using contact mechanisms (e.g., clips or hook-and-loop fasteners) and frequently secured with an external ribbon. Pneumatic cuffs designed for use with a variety of devices, including tourniquets, automated sphygmomanometers, and peripheral compression units, are also available." + }, + { + "input": "Concept: secondary cell septum (division septum)", + "output": "something described as cell wall structures composed of linear polysaccharides which are deposited at both sides of the primary septum at 90 degrees to the primary septum." + }, + { + "input": "Concept: EMO1-Total Negative Stimuli Incorrect (ERT Functional Test Question)", + "output": "ERT Functional Test Question described as emotion Recognition - Total number of negative emotion stimuli (face images) for which the participant's response was incorrect." + }, + { + "input": "Concept: External Intercostal Muscle (Structure of intercostal muscle)", + "output": "Skeletal muscle structure of thorax described as the most superficial of the three intercostal muscles (external, internal, innermost) found in the intercostal space, which aid in both active and passive inhalation." + }, + { + "input": "Concept: SNARE complex disassembly (cellular protein complex disassembly)", + "output": "cellular protein complex disassembly described as the disaggregation of the SNARE protein complex into its constituent components. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers." + }, + { + "input": "Concept: regulation of maintenance of sister chromatin cohesion at centromere at mitosis (regulation of centromeric sister chromatid cohesion)", + "output": "something described as any process that modulates the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion in the centromeric region." + }, + { + "input": "Concept: Synchronous Bilateral Breast Carcinoma (Neoplastic Process)", + "output": "Neoplastic Process described as carcinoma that is detected in one breast within two months from the diagnosis of carcinoma in the other breast." + }, + { + "input": "Concept: Image Processors (Manufactured Object)", + "output": "Electromechanical Devices described as devices designed to acquire and process an electronic image obtained from a separate source (e.g., camera, electronic system). These processors usually include an electronic unit that processes, stores, or transmits the input image and delivers it to peripheral devices (e.g., monitors, printers, workstations) and/or to other computerized systems for storage, retrieval, and/or processing. Dedicated image processors are available for still and video images; devices intended to process fluorescent and ultraviolet images are also available." + }, + { + "input": "Concept: Plasma Cell Tumors (Blood and lymphatic system disorders)", + "output": "B-Cell Lymphomas described as new abnormal plasma cells that grow by excessive cellular division and proliferation more rapidly than normal and continue to grow after the stimuli that initiated the new growth cease." + }, + { + "input": "Concept: Paraffin, Chlorinated (Carcinogenic Chlorinated Hydrocarbon)", + "output": "Organic Chemical described as a yellowish, odorless, viscous, oily carcinogenic chlorinated hydrocarbon. Chlorinated paraffin is used as an extreme pressure lubricant, flame retardant and plasticizer. Chlorinated paraffins, with chain lengths of C12 and chlorine contents of 60%, are reasonably anticipated to be human carcinogens based on evidence of carcinogenicity in experimental animals." + }, + { + "input": "Concept: Lymphoid tissues of gastrointestinal tract (Non-lymphatic lymphoid system)", + "output": "Organized mucosa-associated lymphoid tissue described as non-encapsulated accumulations of lymphoid tissue in the alimentary tract that form a secretory immune system containing cells committed to IgA or IgE synthesis; include tonsils, Peyer's patches, lamina propria, and appendix." + }, + { + "input": "Concept: Barlow maneuver (Physical examination procedures and organ system status)", + "output": "something described as useful in assessing for developmental dysplasia of the hip, this test is performed when the thigh is pushed posteriorly and the hip is adducted. Should the hip become dislocated by this movement, the result is considered positive." + }, + { + "input": "Concept: Stage III Carcinoma of the Nasopharynx AJCC v6 (Stage III Pharynx Carcinoma)", + "output": "stage, nasopharyngeal cancer described as stage III includes: (T1, N2, M0); (T2a, N2, M0); (T2b, N2, M0); (T3, N0, M0); (T3, N1, M0); (T3, N2, M0). T3: Tumor involves bony structures and/or paranasal sinuses. N2: Bilateral metastasis in lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa. M0: No distant metastasis. (AJCC 6th ed.) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C7396\" active clinical trials using this agent." + }, + { + "input": "Concept: formamidase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)", + "output": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides described as catalysis of the reaction: formamide + H(2)O = formate + NH(4)(+)." + }, + { + "input": "Concept: BHLHB5 (Transcription Regulation Gene)", + "output": "something described as this gene is involved in transcriptional regulation." + }, + { + "input": "Concept: Grade 1 Eczema (Finding)", + "output": "something described as asymptomatic or mild symptoms; additional medical intervention over baseline not indicated" + }, + { + "input": "Concept: Zincum metallicum (Mineral supplements)", + "output": "Mineral supplements described as metallic trace element, atomic symbol Zn, atomic number 30; necessary in the diet, forms an essential part of many enzymes, and plays an important role in protein synthesis and in cell division." + }, + { + "input": "Concept: cervical nerves (Non-Autonomic Spinal Nerves)", + "output": "something described as the uppermost eight pairs of spinal nerves ( Kahle-2001 )." + }, + { + "input": "Concept: Recurrent Acute Leukemia (Neoplastic Process)", + "output": "Acute leukemia described as the reemergence of acute leukemia after a period of remission." + }, + { + "input": "Concept: GAD0101 (Intellectual Product)", + "output": "GAD-7 Questionnaire Question described as generalized Anxiety Disorder - 7 - Feeling nervous, anxious or on edge." + }, + { + "input": "Concept: Mycoplasma putrefaciens (Bacterium)", + "output": "Mycoplasma described as a species that is associated with caprine MASTITIS and possesses an intense odor." + }, + { + "input": "Concept: Hypercortisolism (Metabolic Diseases)", + "output": "Korean Standard Classification of Disease Version 5 described as condition, more commonly seen in females, due to hyperadrenocorticism resulting from neoplasms of the adrenal cortex or the anterior lobe of the pituitary, or to prolonged excessive intake of glucocorticoids for therapeutic purposes; symptoms and signs may include rapidly developing adiposity of the face, neck, and trunk, kyphosis caused by osteoporosis of the spine, hypertension, diabetes mellitus, amenorrhea, hypertrichosis in females, impotence in males, dusky complexion with purple markings, polycythemia, pain in the abdomen and back, and muscular wasting and weakness." + }, + { + "input": "Concept: CSS0518A (Intellectual Product)", + "output": "C-SSRS Already Enrolled Subjects Questionnaire Question described as columbia-Suicidality Severity Rating Scale Already Enrolled Subjects (C-SSRS Already Enrolled Subjects ) Total number of aborted. (Prior to Study Entry)." + }, + { + "input": "Concept: down-regulation of G-protein coupled receptor internalization (regulation of G protein-coupled receptor internalization)", + "output": "Cell Function described as any process that stops, prevents or reduces the frequency, rate or extent of G protein-coupled receptor internalization." + }, + { + "input": "Concept: Eyelid Carcinoma cN1 TNM Finding v8 (Finding)", + "output": "something described as eyelid carcinoma with metastasis in a single ipsilateral regional lymph node, measuring 3 cm or less in greatest dimension." + }, + { + "input": "Concept: Intrahepatic Bile Duct Carcinoma pNX TNM Finding v8 (Intrahepatic Bile Duct Cancer Pathologic Regional Lymph Nodes TNM Finding v8)", + "output": "something described as intrahepatic bile duct cancer in which the regional lymph node(s) cannot be assessed." + }, + { + "input": "Concept: CDISC ADAS-Cog - Commands: Pencil (ADAS-Cog CDISC Version Questionnaire Question)", + "output": "something described as alzheimer's Disease Assessment Scale-Cognitive CDISC Version (ADAS-Cog CDISC Version) Commands task for put the pencil on top of the card and then put it back." + }, + { + "input": "Concept: Lithostathine (Pancreatitis-Associated Proteins)", + "output": "Pancreatic Hormones described as the proteinaceous component of the pancreatic stone in patients with PANCREATITIS." + }, + { + "input": "Concept: norepinephrine import (Cell Function)", + "output": "norepinephrine transport described as the directed movement of norepinephrine into a cell, typically presynaptic neurons or glial cells. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." + }, + { + "input": "Concept: protein N-terminal acetyltransferase activity (peptide N-acetyltransferase activity)", + "output": "peptide N-acetyltransferase activity described as catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein." + }, + { + "input": "Concept: cutoff (Property or Attribute)", + "output": "Property or Attribute described as a designated limit beyond which something cannot function, must be terminated, or no longer applies." + }, + { + "input": "Concept: FAC001-I Feel Close to My Partner (FACT-G Version 4 Questionnaire Question)", + "output": "Intellectual Product described as functional Assessment of Cancer Therapy-General Version 4 (FACT-G Version 4) Social/Family Well-Being: I feel close to my partner (or the person who is my main support)." + }, + { + "input": "Concept: Perimeters, Ophthalmic, Automated (Device associated with printers/plotters)", + "output": "something described as ophthalmic perimeters that perform visual field assessment with little operator involvement. Currently, automated perimeters perform static perimetry, as well as simultaneous monitoring of the fixation of the eye. These instruments project targets at predetermined locations in the visual field for patient detection, using one or more procedures for field evaluation (i.e., threshold, supra threshold, threshold-related). Automated perimeters include a stimuli source (projection devices, light-emitting diodes) with automated background illumination and computing capabilities for test programming and data processing, recording, and display." + }, + { + "input": "Concept: Dacetuzumab (Antineoplastic Antibody)", + "output": "Pharmacologic Substance described as a humanized monoclonal antibody directed against the CD40 receptor with potential antineoplastic activity. Dacetuzumab specifically binds to and inhibits the CD40 receptor, thereby inducing apoptosis and inhibiting cellular proliferation via antibody-dependent cellular cytotoxicity (ADCC) in cells that overexpress this receptor. The CD40 receptor, a member of the tumor necrosis factor (TNF) receptor super-family, is highly expressed on most B-lineage hematologic malignancies including multiple myeloma, non-Hodgkin lymphoma, chronic lymphocytic leukemia, Hodgkin disease and acute lymphoblastic leukemia. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C62179\" active clinical trials using this agent." + }, + { + "input": "Concept: Hereditary inclusion body myopathy type 4 (Disease or Syndrome)", + "output": "Hereditary disorder of musculoskeletal system described as a rare non-dystrophic myopathy with characteristics of slowly progressive muscular weakness and atrophy initially involving proximal lower limbs and hip girdle and later on shoulder girdle, proximal upper limbs and axial muscles. Ambulation is usually preserved. Congophilic inclusions with cytoplasmic inclusions of 15-21 nm filaments on electron microscopy are revealed in muscle biopsy." + }, + { + "input": "Concept: stemar-13-ene synthase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the reaction: 9-alpha-copalyl diphosphate = stemar-13-ene + diphosphate." + }, + { + "input": "Concept: Perque(TM) Co Q10 Plus 60 mg each 60 gelcaps (Clinical Drug)", + "output": "Nutraceuticals described as perque(TM) Co Q10 Plus 60 mg each 60 gelcaps. UPC Code 791760016409." + }, + { + "input": "Concept: PATHOL CONDITIONS SIGNS SYMPTOMS (German translation of the Medical Subject Headings)", + "output": "Diseases described as abnormal anatomical or physiological conditions and objective or subjective manifestations of disease, not classified as disease or syndrome." + }, + { + "input": "Concept: Pus, NOS (Exudative inflammation)", + "output": "Body Substance described as a yellowish substance produced during bacterial inflammation. It contains necrotic cells and cells fighting the infection." + }, + { + "input": "Concept: Physical Examination Result (Result)", + "output": "something described as the outcome of the physical examination assessment." + }, + { + "input": "Concept: benzoyl-CoA:taxane 2alpha-O-benzoyltransferase activity (transferase activity, transferring acyl groups other than amino-acyl groups)", + "output": "Molecular Function described as catalysis of the reaction: 10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA = 10-deacetylbaccatin III + CoA." + }, + { + "input": "Concept: CDC Enteric Group 16 (Vibrio species a-m)", + "output": "Non-cholerae vibrio described as a species of facultatively anaerobic, Gram negative, curved rod shaped bacteria assigned to the phylum Proteobacteria. This species is motile, oxidase negative, halophilic, hemolytic, cannot convert nitrate to nitrite and can use a wide variety of sugars as carbon sources. V. metschnikovii is a marine organism and can cause gastroenteritis." + }, + { + "input": "Concept: dynein light intermediate chain binding (Protein Binding)", + "output": "Molecular Function described as interacting selectively and non-covalently with a light intermediate chain of the dynein complex." + }, + { + "input": "Concept: marriage/marital status (Finding)", + "output": "Family described as social institution involving legal and/or religious sanction whereby men and women are joined together for the purpose of founding a family unit; demographic parameter indicating a person's status with respect to marriage, divorce, widowhood, singleness, etc." + }, + { + "input": "Concept: How often have you felt restless, tense, or uptight (Intellectual Product)", + "output": "something described as a question about an individual feeling restless, tense, or uptight." + }, + { + "input": "Concept: XPF (FA Complementation Group Gene)", + "output": "something described as this gene is involved in nucleotide excision repair and is involved in the correction of defective nucleotide excision repair in xeroderma pigmentosum cells of complementation group F." + }, + { + "input": "Concept: negative regulation of raffinose anabolism (negative regulation of biosynthetic process)", + "output": "something described as any process that stops, prevents or reduces the frequency, rate or extent of raffinose biosynthetic process." + }, + { + "input": "Concept: viral RNA (Nucleocapsid)", + "output": "RNA described as ribonucleic acid that makes up the genetic material of viruses." + }, + { + "input": "Concept: Absent foetal heart rate variability (Fetal heart rate variability - finding)", + "output": "something described as fetal heart rate variability not detected during intrapartum fetal heart monitoring." + }, + { + "input": "Concept: MCGN - Mesangiocapillary GN (Glomerulonephritis)", + "output": "Renal glomerular disease described as a type of glomerulonephritis characterized by diffuse mesangial cell proliferation and the thickening of capillary walls due to subendothelial extension of the mesangium. The term membranoproliferative glomerulonephritis is often employed to denote a general pattern of glomerular injury seen in a variety of disease processes that share a common pathogenetic mechanism, rather than to describe a single disease entity" + }, + { + "input": "Concept: EC 2.6.1 (Amino Acid, Peptide, or Protein)", + "output": "Nitrogenous Group Transferases described as a subclass of enzymes of the transferase class that catalyze the transfer of an amino group from a donor (generally an amino acid) to an acceptor (generally a 2-keto acid). Most of these enzymes are pyridoxyl phosphate proteins. (Dorland, 28th ed) EC 2.6.1." + }, + { + "input": "Concept: Undersensing (Invalid Sensing Medical Device Problem)", + "output": "Finding described as problem related to failure of the device to properly detect intrinsic cardiac activity and respond appropriately." + }, + { + "input": "Concept: uIU/mL/(ug/m2) (Unit of concentration)", + "output": "Unit of concentration described as a unit of concentration (biologic activity) equal to one milli-international unit per milliliter, divided by milligrams per meter squared." + }, + { + "input": "Concept: Cardiac Compression Boards (Cardiovascular equipment)", + "output": "HOSPITAL FURNITURE AND AMBULATION DEVICES described as a cardiopulmonary resuscitation board is a device consisting of a rigid board which is placed under a patient to act as a support during cardiopulmonary resuscitation." + }, + { + "input": "Concept: CYP2D6*21 Allele (Gene or Genome)", + "output": "something described as human CYP2D6*21 allele is located in the vicinity of 22q13.1 and is approximately 4 kb in length. This allele, a variant form of the CYP2D6 wild-type allele, encodes cytochrome P450 2D6*21 protein. The CYP2D6*21 allele exhibits a single nucleotide insertion (g.2573insC) in exon 5 that results in a frameshift and generates a stop codon 17 bp downstream of the insertion site. This alteration abolishes the enzymatic activity of the cytochrome P450 2D6*21 protein." + }, + { + "input": "Concept: downregulation of sodium:hydrogen antiporter activity (regulation of sodium:proton antiporter activity)", + "output": "something described as any process that stops or reduces the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." + }, + { + "input": "Concept: Appendiceal Carcinoma pNX TNM Finding v8 (Finding)", + "output": "something described as appendiceal carcinoma in which the regional lymph node(s) cannot be assessed." + }, + { + "input": "Concept: AZURIN-P28 (Amino Acid, Peptide, or Protein)", + "output": "Antineoplastic Agents described as a water-soluble, amphipathic, 28 amino acid (amino acids 50-77), 2.9 kD fragment peptide (p28) derived from the protein azurin with potential antineoplastic and antiangiogenic activities. Although the mechanism has yet to be fully elucidated, the preferential cellular uptake of azurin-derived cell-penetrating peptide p28 by tumor cells and endothelial cells is likely via caveolae-mediated endocytosis; the C-terminal 18 amino acid residues (50-67) appear to be responsible for this preferential uptake. After cell entry, the first 12 amino acid residues interact with tumor suppressor p53 and form a p28:p53 complex, which may result in a reduction of proteasomal degradation of p53, increased p53 levels, and p53-mediated cell cycle inhibition and apoptosis. Azurin is a cupredoxin secreted by the bacterium Pseudomonas aeruginosa. Cell penetrating peptides (CPPs) are cationic and/or amphipathic peptides, typically less than 30 amino acids in length, that can penetrate cell membranes easily and may transport molecular cargo." + }, + { + "input": "Concept: regulation of ent-pimara-8(14),15-diene biosynthetic process (regulation of cellular biosynthetic process)", + "output": "regulation of isoprenoid metabolic process described as any process that modulates the frequency, rate or extent of ent-pimara-8(14),15-diene biosynthetic process." + }, + { + "input": "Concept: Stage IIIB Colon Cancer (Stage IIIB Colorectal Cancer AJCC v8)", + "output": "something described as stage IIIB includes: (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0). T1: Tumor invades the submucosa (through the muscularis mucosa but not into the muscularis propria). T2: Tumor invades the muscularis propria. T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). N1: One to three regional lymph nodes are positive (tumor in lymph nodes measuring 0.2 mm or more), or any number of tumor deposits are present and all identifiable lymph nodes are negative. N1c: No regional lymph nodes are positive, but there are tumor deposits in the subserosa, mesentery, or nonperitonealized pericolic, or perirectal/mesorectal tissues. N2a: Four to six regional lymph nodes are positive. N2b: Seven or more regional lymph nodes are positive. M0: No distant metastasis." + }, + { + "input": "Concept: Endoribonuclease (Enzyme)", + "output": "Ribonucleases described as a family of enzymes that catalyze the endonucleolytic cleavage of RNA. It includes EC 3.1.26.-, EC 3.1.27.-, EC 3.1.30.-, and EC 3.1.31.-." + }, + { + "input": "Concept: cardiac neural crest cell development involved in heart development (neural crest cell development)", + "output": "something described as the process aimed at the progression of a cardiac neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell that contributes to the development of the heart." + }, + { + "input": "Concept: Homogeneously Staining Region (Chromosome Aberrations)", + "output": "Cell or Molecular Dysfunction described as a region on a chromosome which, when stained, is uniform in appearance. (Normally, a stained chromosome shows a banding pattern.) Homogeneously staining regions contain multiple copies of a single gene." + }, + { + "input": "Concept: \"Technologists, Technicians & Other Technical Service Providers\"; Pathology, \"Clinical Laboratory Director, Non-physician\" (Professional or Occupational Group)", + "output": "Professional or Occupational Group described as an individual who is state-licensed as a clinical laboratory director and meets the qualifications in the Clinical Laboratory Improvement Amendments of 1988 for non-physicians (non-MD/DO) as defined in the CFR 42 Part 493.1405." + }, + { + "input": "Concept: Stents, Vascular, Intracranial Artery, Aneurysm Bifurcation (Medical Device)", + "output": "something described as vascular stents designed for deployment into the intracranial arteries at or near a vessel bifurcation to provide a bypass across the neck of a wide-neck aneurysm, allowing the aneurysm to be filled with coils or other appropriate particles. Clots formed around the implanted coils are intended to provide aneurysm sealing. Intracranial aneurysm bifurcation stents are usually flexible nitinol self-expanding stents with a hybrid cell structure that allows the pass of the coils into the aneurysm; they are used when open intracranial surgery is not possible or desirable." + }, + { + "input": "Concept: Implant (RouteByMethod)", + "output": "Parenteral Route of Drug Administration described as drug administration via imbedded implants used as depot formulations to limit high drug concentrations to the area surrounding the pathology or to provide sustained drug release for systemic therapy. Implant systems are used when chronic therapy is indicated and may take the form of highly viscous liquids, semi-solid formulations, rod impregnated with drug substances, or a liquid which gels in situ. Release kinetics may be controlled by varying polymer composition, different types of stimuli, such as electrical, and varying of implant structure, e.g. as coating." + }, + { + "input": "Concept: District of Columbia, District of Columbia (US County)", + "output": "Region of United States of America described as the area in the United States comprised of a 68 square mile area northeast of the Potomac River donated by the state of Maryland. The District of Columbia, also known as D.C., is not a state, nor is it part of any state. It is a \"federal district\" established by the US Constitution as the seat of government. The district is occupied entirely by the city of Washington." + }, + { + "input": "Concept: up regulation of cellobiose catabolic process (positive regulation of cellobiose metabolic process)", + "output": "Molecular Function described as any process that activates or increases the frequency, rate or extent of cellobiose catabolic process." + }, + { + "input": "Concept: regulation of protein catabolic process in the vacuole (regulation of cellular protein catabolic process)", + "output": "something described as any process that modulates the frequency, rate or extent of protein catabolic process in the vacuole." + }, + { + "input": "Concept: Usual new 30 minutes out-of-office personal training intake (Health Care Activity)", + "output": "Remote location new client without ICD diagnosis described as using personal training assessment methods in a usual, 30-minute, out-of-office meeting to assess the health status of a new client to develop a personal training plan." + }, + { + "input": "Concept: B-Cell Receptor Binding (Receptor Binding)", + "output": "Molecular Function described as a process that involves the binding of an antigen to the transmembrane B cell receptor, an IgD molecule. These interactions are involved in signaling the B cell to be activated and to participate in immune function." + }, + { + "input": "Concept: Caspase cascade in apoptosis (Molecular Function)", + "output": "Apoptosis Regulation Pathway described as apoptosis, programmed cell death, is triggered by a variety of stimuli, including cell surface receptors like FAS, mitochondrial response to stress, and cytotoxic T cells. Caspases are a class of cysteine proteases that includes several representatives involved in apoptosis. The caspases convey the apoptotic signal in a proteolytic cascade, with caspases cleaving and activating other caspases that then degrade other cellular targets that lead to cell death. The caspases at the upper end of the cascade include caspase-8 and caspase-9. Caspase-8 is the initial caspase involved in response to receptors with a death domain like FAS. The mitochondrial stress pathway begins with the release of cytochrome c from mitochondria, which then interacts with Apaf-1, causing self-cleavage and activation of caspase-9. Caspase-3, -6, and -7 are downstream caspases that are activated by the upstream proteases and act themselves to cleave cellular targets. Granzyme B and perforin proteins released by cytotoxic T cells induce apoptosis in target cells, forming transmembrane pores, and triggering apoptosis, perhaps through cleavage of caspases, although caspase-independent mechanisms of Granzyme B mediated apoptosis have been suggested." + }, + { + "input": "Concept: xsmv (Superior medullary velum)", + "output": "Superior medullary velum described as a substructure of the superior medullary velum ( Crosby-1962 )." + }, + { + "input": "Concept: Fluphenazine hydrochloride [dup] (Pharmacologic Substance)", + "output": "Antipsychotic Agents described as a drug that is used to treat mental and emotional disorders and is being studied in the treatment of multiple myeloma. Fluphenazine hydrochloride may stop tumor growth by keeping myeloma cells from dividing and causing them to die. It is a type of antipsychotic." + }, + { + "input": "Concept: ERIS (Signaling Pathway Gene)", + "output": "Gene or Genome described as this gene plays a role in the immune response." + }, + { + "input": "Concept: 3-(2,3-dihydroxyphenyl)propionate 1,2-dioxygenase activity (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen)", + "output": "dioxygenase activity described as catalysis of the reaction: 3-(2,3-dihydroxyphenyl)propionate + O2 = 2-hydroxy-6-keto-nona-2,4-dienedioate." + }, + { + "input": "Concept: Lymph Node by Anatomic Site (Classification)", + "output": "something described as a lymph node named according to its location in the body." + }, + { + "input": "Concept: Hypophyseal Disorder (Abnormality of brain morphology)", + "output": "Hypothalamic Dysfunction Syndromes described as disorders of the anterior or posterior pituitary gland which usually manifest as hypersecretion or hyposecretion of pituitary hormones." + }, + { + "input": "Concept: septum of brain (Body Part, Organ, or Organ Component)", + "output": "Limbic System described as GRAY MATTER structures of the telencephalon and LIMBIC SYSTEM in the brain, but containing widely varying definitions among authors. Included here is the cortical septal area, subcortical SEPTAL NUCLEI, and the SEPTUM PELLUCIDUM." + }, + { + "input": "Concept: Recessed-Needle Intravenous Line Connectors (Intravenous Line Connectors)", + "output": "something described as intravenous line connectors designed to allow access to the Y-site of either a primary set or an injection adapter on the infusion catheter. Typically, a needle located inside a plastic housing can be inserted into a standard septum and a Luer fitting located at the opposite end allows the connection of a syringe or infusion set. A manual or automated mechanism moves the housing to protect the operator from the needle once the infusion is finished. Recessed-needle connectors are intended to eliminate an exposed needle after administration of medications." + }, + { + "input": "Concept: Tachycardia, Atrioventricular Nodal Reentry (Tachycardia, Reciprocating)", + "output": "something described as abnormally rapid heartbeats caused by reentry of atrial impulse into the dual (fast and slow) pathways of ATRIOVENTRICULAR NODE. The common type involves a blocked atrial impulse in the slow pathway which reenters the fast pathway in a retrograde direction and simultaneously conducts to the atria and the ventricles leading to rapid HEART RATE of 150-250 beats per minute." + }, + { + "input": "Concept: Grade 1 Hypophysitis, CTCAE (Hypophysitis, CTCAE)", + "output": "Finding described as asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated" + }, + { + "input": "Concept: Genetic Diseases (Disease or Syndrome)", + "output": "Disease or Syndrome described as general term for any disorder caused by a genetic mechanism, comprising chromosome aberrations or anomalies, mendelian or monogenic or single-gene disorders, and multifactorial disorders; note that all genetic disorders are not treed under this term; see RTs for others; in addition, many disorders not treed here or under RTs may have a genetic component." + }, + { + "input": "Concept: Aspergillus Fumigatus Complex (Aspergillus)", + "output": "Fungus described as a non-taxonomic grouping of fungal species that are morphologically similar to the Aspergillus fumigatus species." + }, + { + "input": "Concept: Carts, Storage/Transport, Radioactive Material (Carts, Storage/Transport)", + "output": "Carts, Storage/Transport described as storage/transport carts designed for temporary storage and local transportation of radioactive materials inside a particular area of a healthcare facility. These carts usually consist of a sturdy metal structure mounted on medium or large wheels (typical diameter of 7.5 to 12.5 cm/3 to 5 in) that are capable of supporting heavy weights. The carts typically include a detachable container with a single- or double-lined as shielding for the radioactive material. Some carts do not include shielding, making it necessary to use double-shielded radioactive safe containers for transportation. Radioactive material carts are used to transport radioactive materials such as radiopharmaceuticals, PET isotopes, and radium inside nuclear medicine areas and/or from those areas to the patient room." + }, + { + "input": "Concept: Routinely Collected Health Data (Intellectual Product)", + "output": "something described as data collected for purposes other than research. Examples include health administrative data, electronic health records, and disease or clinical registries." + }, + { + "input": "Concept: anaerobic bacteria (Bacteria)", + "output": "Microorganism described as bacteria that can survive and grow in the complete, or nearly complete absence of oxygen." + }, + { + "input": "Concept: Wnt5b (WNT Family Protein)", + "output": "something described as protein Wnt-5b (359 aa, ~40 kDa) is encoded by the human WNT5B gene. This protein plays a role in the initiation of G protein-coupled receptor signaling." + }, + { + "input": "Concept: Visceral calciphylaxis (Calciphylaxis)", + "output": "something described as a rare life-threatening non-inflammatory vasculopathy disorder characterised by diffuse precipitation of calcium in viscera (mainly in the heart or lungs, but also in the stomach or kidneys) leading to fibrosis and thrombosis, which eventually cause necrotic ulcerations of the tissue. Patients may present with dyspnoea, cough and respiratory failure or acute heart block and subsequent sudden cardiac death, depending on the affected organ. The disease mainly affects patients on dialysis or patients having undergone renal transplantation." + }, + { + "input": "Concept: FACIT-Dyspnea Scale 33 Item Bank Version - Severity: Walking 1/2 Mile (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)", + "output": "Intellectual Product described as functional Assessment of Chronic Illness Therapy-Dyspnea Scale 33 Item Bank - Dyspnea Severity: Over the past 7 days, how short of breath did you get with each of these activities?: Walking 1/2 mile (almost 1 km) on flat ground at a normal speed without stopping." + }, + { + "input": "Concept: External Qi Therapy (Therapeutic or Preventive Procedure)", + "output": "something described as a form of traditional Chinese energy therapy that involves the use of hand movements, acupressure, focused attention, and other mind healing techniques to direct the therapist's emitted Qi into a patient to regulate the patient's Qi activity." + }, + { + "input": "Concept: plastid rRNA transcription (plastid transcription)", + "output": "rRNA transcription described as the synthesis of ribosomal RNA (rRNA) from a plastid DNA template, usually by a specific plastid RNA polymerase." + }, + { + "input": "Concept: plasmacytoid dendritic cell differentiation (plasmacytoid dendritic cell activation)", + "output": "plasmacytoid dendritic cell activation described as the process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell." + }, + { + "input": "Concept: DRRI-2 - H: Prepared to Operate as Team (DRRI-2 Questionnaire Question)", + "output": "DRRI-2 Questionnaire Question described as deployment Risk & Resilience Inventory-2 - In preparation for deployment: my unit was well-prepared to operate as a team during deployment." + }, + { + "input": "Concept: Neural Pathways (Peripheral Nervous System Part)", + "output": "something described as neural tracts connecting one part of the nervous system with another." + }, + { + "input": "Concept: Grade 2 Skin Infection, CTCAE (Skin Infection, CTCAE)", + "output": "Skin Infection, CTCAE described as oral intervention indicated" + }, + { + "input": "Concept: INTLK18 (Laboratory Procedure)", + "output": "Cytokine Measurement described as a measurement of the interleukin 18 in a biological specimen." + }, + { + "input": "Concept: ABIN2-NFKB1-TPL-1 complex (protein-containing complex)", + "output": "Cell Component described as a protein complex that contains the precursor form of NF-kappaB (p105), the NF-kappaB inhibitor ABIN-2, and the kinase TPL-2 (MAP3K8); the complex stabilizes TPL-2 and is involved in signaling in lipopolysaccharide (LPS)-stimulated macrophages." + }, + { + "input": "Concept: Kaposi's Sarcoma NCI Grade 3 (Neoplastic Process)", + "output": "Neoplastic Process described as a Kaposi sarcoma with more than 15% necrosis." + }, + { + "input": "Concept: Tissue Kallikrein Deficiency (Disease or Syndrome)", + "output": "Disease or Syndrome described as a disorder characterized by the partial or complete absence of tissue-type kallikrein activity in the tissues and glandular secretions where it is normally present." + }, + { + "input": "Concept: Double outlet right ventricle with doubly committed ventricular septal defect without pulmonary stenosis (Congenital Abnormality)", + "output": "Congenital Abnormality described as a double outlet right ventricle with a subaortic ventritricular septal defect (a hole between the two bottom chambers (ventricles) of the heart), that extends anterosuperiorly and are closely related to the pulmonary artery as well, are considered to be doubly committed. There is not associated pulmonary stenosis, the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches." + }, + { + "input": "Concept: ERBB c.2238 2252del15 (Cell or Molecular Dysfunction)", + "output": "EGFR Exon 19 Deletion Mutation described as a deletion of 15 nucleotides from the coding sequence of the EGFR gene from position 2238 through 2252." + }, + { + "input": "Concept: growth factor receptor-bound protein 3-3, human (Biologically Active Substance)", + "output": "Adaptor Proteins, Signal Transducing described as growth factor receptor-bound protein 2 (217 aa, ~25 kDa) is encoded by the human GRB2 gene. This protein is involved in the progression of epidermal growth factor-mediated signaling pathways." + }, + { + "input": "Concept: Dentistry, Military (Dentistry)", + "output": "something described as the practice of dentistry as applied to special circumstances associated with military operations." + }, + { + "input": "Concept: Burkholderia cepacia Complex (Bacterium)", + "output": "something described as a group of phenotypically similar but genotypically distinct species (genomovars) in the genus BURKHOLDERIA. They are found in water, soil, and the rhizosphere of crop plants. They can act as opportunistic human pathogens and as plant growth promoting and biocontrol agents." + }, + { + "input": "Concept: negative regulation of glycoprotein biosynthetic process (Organism Function)", + "output": "Organism Function described as any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." + }, + { + "input": "Concept: CAROTID-CAVERNOUS FISTULA (Peripheral Vascular Diseases)", + "output": "Vascular Diseases described as an abnormal connection between a carotid artery and the cavernous sinus." + }, + { + "input": "Concept: MEKKK 3 (Amino Acid, Peptide, or Protein)", + "output": "Protein-Serine-Threonine Kinases described as mitogen-activated protein kinase kinase kinase kinase 3 (894 aa, ~101 kDa) is encoded by the human MAP4K3 gene. This protein plays a role in the Jun signaling pathway." + }, + { + "input": "Concept: Surgery, Outpatient (Surgical Procedure by Type)", + "output": "Operative Surgical Procedures described as surgery performed on an outpatient basis. It may be hospital-based or performed in an office or surgicenter." + }, + { + "input": "Concept: Filtration Systems, Intravascular Procedure (Electromechanical Devices)", + "output": "something described as filtration systems designed to trap emboli and/or other debris that is liberated during intravascular procedures using a distal filter. These systems typically include a hollow guidewire, a membrane filter, delivery and/or retrieval sheaths, and a mechanism to actuate the filter. The system filter is routed through the artery and deployed distal to the lesion to be treated; after the procedure is finished the filter is retrieved (usually through a retrieval sheath) and removed from the vasculature. Some systems are based on the use of delivery and retrieval catheters or other similar technologies. Intravascular procedure filtration systems are used temporarily during deployment of stents or catheter balloons; some dedicated filtration systems are only intended for a particular application (e.g., carotid artery, saphenous vein graft)." + }, + { + "input": "Concept: Childrearing Care (Family)", + "output": "Health Care Activity described as interventions to assist in raising children" + }, + { + "input": "Concept: Absent bronchoalveolar dimeric surfactant-protein B (Abnormal bronchoalveolar fluid protein level)", + "output": "Abnormal bronchoalveolar fluid protein level described as significantly decreased level or failed detection of surfactant protein B in broncho-alveolar lavage fluid." + }, + { + "input": "Concept: Additional Surgery (Surgical Procedure by Type)", + "output": "Surgical Procedure by Type described as any surgical procedure performed subsequent to a primary or initial surgical procedure." + }, + { + "input": "Concept: Volume Measurement Kits, Arm/Forearm (Medical Device)", + "output": "Medical Device described as prepackaged collection of reusable devices designed for in-vivo accurate measurement of the volume of a forearm and/or the forearm and arm (i.e., the complete upper limb) volume and/or its variations. These kits typically consist of a graduated disposable container with appropriate volume and shape for total immersion of the forearm/arm. The container is filled with water or other solution that is displaced by the immersion of the limb. The container includes an output beak, an overflow liquid container to receive the displaced water caused by the immersion, and a burette to measure the displaced water. Arm/forearm volume measuring kits are intended mainly to assess changes in the volume of an arm to evaluate abnormal physiologic conditions such as edema." + }, + { + "input": "Concept: Achillea filipendulina / golden yarrow (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as golden yarrow." + }, + { + "input": "Concept: EEG with temporal sharp slow waves (Finding)", + "output": "something described as EEG with sharp slow waves in the temporal region. Sharp slow waves are focal sharp transient waves of a duration between 80 and 200 msec followed by a slow wave." + }, + { + "input": "Concept: SEND-MITESTCD (Intellectual Product)", + "output": "something described as the terminology that includes concepts relevant to the Clinical Data Interchange Standards Consortium (CDISC) Standard for the Exchange of Non-clinical Data (SEND) microscopic findings test short names." + }, + { + "input": "Concept: hydrochloric acid preparations (Gastric Juice)", + "output": "Chlorine Compounds, Inorganic described as hydrochloric acid." + }, + { + "input": "Concept: Congenital retraction of eyelid (Congenital anomaly of eyelid)", + "output": "Congenital anomaly of eyelid described as a very rare kinetic eyelid anomaly that can affect the upper or lower eyelid, presents at birth, that in some cases can result in corneal exposure, and that may be associated with accessory levator muscle slips." + }, + { + "input": "Concept: p-glycoprotein (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as gene product of the multidrug resistance gene mdr-1, believed to be a membrane spanning transporter that can pump a wide variety of cytotoxic agents out of the cell." + }, + { + "input": "Concept: Epithelial-to-Mesenchymal Transition (Cell Transdifferentiation)", + "output": "mesenchymal cell differentiation described as a transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." + }, + { + "input": "Concept: 2-MpP Phosphopeptide-tetanus Peptide Vaccine (Cancer Vaccines)", + "output": "Cancer Vaccines described as a vaccine composed of phosphorylated peptides from the tumor associated antigens breast cancer anti-estrogen resistance-3 (BCAR3) and insulin receptor substrate-2 (IRS2) and a tetanus-derived peptide, with potential immunomodulating and antineoplastic activities. Upon administration of pBCAR3/pIRS2 phosphopeptide-tetanus peptide vaccine, the pBCAR3/pIRS2 phosphopeptide may stimulate the immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing either phosphopeptide. The tetanus peptide serves as an immunoadjuvant and induces a helper T-cell response which may help stimulate an immune response against pBCAR3 and pIRS2-expressing melanoma tumor cells. BCAR3 and IRS2 are upregulated in a variety of cancer cells." + }, + { + "input": "Concept: compact part of the dorsomedial hypothalamic nucleus (Body Part, Organ, or Organ Component)", + "output": "Body Part, Organ, or Organ Component described as a part of the dorsomedial nucleus of the hypothalamus in the macaque ( Paxinos-2009a ), the rat ( Paxinos-2009b ), and the mouse ( Franklin-2008 ). It is the only subpart of the nucleus in the macaque. The rodents, however, have in addition a dorsal part of the dorsomedial hypothalamic nucleus and a ventral part of the dorsomedial hypothalamic nucleus ( Paxinos-2009b; Franklin-2008 )." + }, + { + "input": "Concept: Part-Solid Nodule (Nodule Consistency)", + "output": "something described as nodule with both ground-glass and solid components. The solid component corresponds to NO underlying normal anatomy, obscures the underlying lung structures and should measure at least 2 mm. The solid component should be measured in longest dimension." + }, + { + "input": "Concept: B1 (Genes, Regulator)", + "output": "something described as this gene plays a role in ciliogenesis." + }, + { + "input": "Concept: QUANTIFIABLE MRD POSITIVITY (Disease Response)", + "output": "something described as presence of quantifiable residual disease based on laboratory techniques." + }, + { + "input": "Concept: Knife, device (Device Component or Accessory)", + "output": "Sharp instrument described as a cutting device usually consisting of a sharpened blade attached to a handle." + }, + { + "input": "Concept: cellular birth scar (cellular anatomical entity)", + "output": "something described as crater-like ring of chitinous scar tissue located on the surface of the daughter cell, in budding fungi, at the site of separation from the mother cell. It is formed after the newly emerged daughter cell separates, thereby marking the site of cytokinesis and septation." + }, + { + "input": "Concept: hydroxyproline transport (Cell Function)", + "output": "amino acid transport described as the directed movement of hydroxyproline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." + }, + { + "input": "Concept: phase contrast (Light Microscopy)", + "output": "Microscopy technique described as a microscopic technique in which the amplitude shift that occurs when light passes through a specimen highlights structures or details within the specimen." + }, + { + "input": "Concept: positive regulation of macroautophagy (regulation of macroautophagy)", + "output": "regulation of macroautophagy described as any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation." + }, + { + "input": "Concept: Stage IIA Large Cell Carcinoma of the Lung (Neoplastic Process)", + "output": "something described as stage IIA includes: (T2b, N0, M0); (T1a, N1, M0); (T1b, N1, M0); (T2a, N1, M0). T2b: Lung cancer with a tumor size more than 5 cm but 7 cm or less in greatest dimension. T1a: Lung cancer with a tumor size of 2 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus). The uncommon superficial tumor of any size with its invasive component limited to the bronchial wall, which may extend proximal to the main bronchus, is also classified as T1a. T1b: Lung cancer with a tumor size more than 2 cm but 3 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus). T2a: Lung cancer with a tumor size more than 3 cm but 5 cm or less in greatest dimension. N0: No regional lymph node metastasis. N1: Lung cancer with metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary lymph nodes, including involvement by direct extension. M0: No distant metastasis." + }, + { + "input": "Concept: DRRI-2 - G: Concerned Encounter Explosive (DRRI-2 Questionnaire Question)", + "output": "Intellectual Product described as deployment Risk & Resilience Inventory-2 - During deployment: I was concerned that I would encounter an explosive device (for example, a roadside bomb, mine, or booby trap)." + }, + { + "input": "Concept: EIF2B-BETA (Gene or Genome)", + "output": "something described as this gene plays a role in the regulation of protein translation." + }, + { + "input": "Concept: RNA polymerase II cis-regulatory region sequence-specific DNA binding (cis-regulatory region sequence-specific DNA binding)", + "output": "Genetic Function described as interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II." + }, + { + "input": "Concept: Mam-2 (Amino Acid, Peptide, or Protein)", + "output": "Transcription Regulatory Protein described as mastermind-like protein 2 (1156 aa, ~125 kDa) is encoded by the human MAML2 gene. This protein plays a role in the mediation of transcription." + }, + { + "input": "Concept: Copiktra Regimen (Regimen Used to Treat Chronic Lymphocytic Leukemia)", + "output": "something described as a chemotherapy regimen consisting of duvelisib that may be used in the treatment of chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), and follicular lymphoma." + }, + { + "input": "Concept: Feeding environment table service management (Health Care Activity)", + "output": "Nutrition environment management described as initiate, modify, or discontinue table service (e.g., plates, napkins) management as a nutrition intervention" + }, + { + "input": "Concept: Phenylthiohydantoin (Organic Chemical)", + "output": "something described as thiohydantoin benzene derivative." + }, + { + "input": "Concept: ZyrTEC (Organic Chemical)", + "output": "something described as brand name of an allergy medicine" + }, + { + "input": "Concept: Traumatic Injury (Accidents, poisoning and injury)", + "output": "Disease described as disorder resulting from physical damage to the body" + }, + { + "input": "Concept: brain and muscle ARNT-like 1 (Gene or Genome)", + "output": "Gene or Genome described as this gene is involved in transcriptional activation." + }, + { + "input": "Concept: IL13Ralpha2-specific hinge-optimized 41BB-co-stimulatory CAR truncated CD19-expressing autologous T-lymphocytes (Antineoplastic Immune Cell)", + "output": "Chimeric Antigen Receptor T-cells described as a preparation of ex vivo expanded, genetically modified autologous central memory-enriched T-cells (Tcm) transduced with a replication incompetent, self-inactivating (SIN) lentiviral vector expressing a hinge-optimized, chimeric antigen receptor (CAR) specific for interleukin-13 receptor alpha 2 (IL13Ra2), and containing the cluster of differentiation 137 (CD137; 4-1BB) co-stimulatory signaling domain fused to the signaling domain of the T cell antigen receptor complex zeta chain (CD3-zeta), and a truncated form of human cluster of differentiation 19 (CD19t), with potential immunostimulating and antineoplastic activities. Upon intratumoral or intracavitary administration, IL13Ra2-specific, hinge-optimized, 41BB-co-stimulatory CAR/truncated CD19 expressing T-lymphocytes are directed to, and induce selective toxicity and cytolysis in IL13Ra2-expressing tumor cells. IL13Ra2, overexpressed by a variety of tumor cell types, is associated with increased tumor cell proliferation, migration and invasiveness. The costimulatory signaling domain enhances both proliferation of T-cells and antitumor activity. Hinge optimization prevents the recognition and clearance of the CAR by endogenous Fc receptors (FcRs). CD19t is used as a surface marker to both quantify and track the gene modified T-cells in vivo." + }, + { + "input": "Concept: Resistant (Physiologic Function)", + "output": "something described as a Resistance Process consists of activities of biologic molecules or complexes involved in processes that maintain immunity to, or counteract, defeat, or withstand the effects of, an antagonistic agent." + }, + { + "input": "Concept: NCCN-FACT FBRSI-24 Version 2 - Frustrated I Cannot Do Things (NCCN-FACT FBRSI-24 Version 2 Questionnaire Question)", + "output": "Intellectual Product described as national Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Brain Symptom Index-24 Version 2 (NCCN-FACT FBRSI-24 Version 2) I get frustrated that I cannot do things I used to." + }, + { + "input": "Concept: butanoyl-CoA:glyoxylate C-butanoyltransferase (transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer)", + "output": "something described as catalysis of the reaction: butanoyl-CoA + glyoxylate + H(2)O = 3-ethylmalate + CoA + H(+)." + }, + { + "input": "Concept: indolepyruvic acid methyltransferase activity (S-adenosylmethionine-dependent methyltransferase activity)", + "output": "S-adenosylmethionine-dependent methyltransferase activity described as catalysis of the reaction: S-adenosyl-L-methionine + (indol-3-yl)pyruvate = S-adenosyl-L-homocysteine + (S)-3-(indol-3-yl)-2-oxobutanoate." + }, + { + "input": "Concept: UDP-N-acetyl-alpha-D-fucosamine dehydrogenase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the reaction: UDP-N-acetyl-alpha-D-fucosamine + NAD(P) = UDP-2-acetamido-4-dehydro-2,6-dideoxy-beta-D-glucose + H+ + NAD(P)H." + }, + { + "input": "Concept: Grade 3 Dry skin (Dry Skin, CTCAE)", + "output": "something described as covering >30% BSA and associated with pruritus; limiting self care ADL" + }, + { + "input": "Concept: Translocation (Activity)", + "output": "something described as the movement of a physical object from one place to another." + }, + { + "input": "Concept: Abnormal serum methylfolate Level (Finding)", + "output": "Finding described as an abnormal concentration of 5-methyltetrahydrofolate in the blood. []" + }, + { + "input": "Concept: dJ447F3.2 (UBE2C gene)", + "output": "something described as human UBE2C wild-type allele is located in the vicinity of 20q13.12 and is approximately 4 kb in length. This allele, which encodes ubiquitin-conjugating enzyme E2 C protein, plays a role in both the mediation of protein ubiquitination and the regulation of mitosis." + }, + { + "input": "Concept: NY-ESO-1 plasmid DNA cancer vaccine (Pharmacologic Substance)", + "output": "Immunologic Factor described as a plasmid DNA encoding an immunogenic peptide derived from the cancer-testis antigen NY-ESO-1 with potential immunostimulating and antitumor activities. Upon adninstration, NY-ESO-1 plasmid DNA cancer vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells expressing the NY-ESO-1 antigen, resulting in tumor cell lysis. NY-ESO-1 is a tumor associated antigen (TAA) found in normal testes and expressed on the surfaces of various tumor cells, including melanoma, breast, bladder, prostate, lung, ovarian, and hepatocellular tumor cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C62452\" active clinical trials using this agent." + }, + { + "input": "Concept: Sedimentation Field Flow Fractionation (Laboratory Procedure)", + "output": "something described as sedimentation field is either gravitational or centrifugal." + }, + { + "input": "Concept: VFQ25-Self Administered Format - Difficulty Entertaining Friends and Family in Home (Intellectual Product)", + "output": "something described as national Eye Institute Visual Functioning Questionnaire - 25 Version 2000 Self-Administered Format - Social Function: Because of your eyesight, how much difficulty do you have entertaining friends and family in your home?" + }, + { + "input": "Concept: pirotinib (Organic Chemical)", + "output": "Organic Chemical described as an orally bioavailable inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB; EGFR) family, with potential antineoplastic activity. Upon administration, pirotinib selectively and irreversibly binds to and inhibits the epidermal growth factor receptors 1 (ErbB1; EGFR), 2 (ErbB2; HER2), and 4 (ErbB4; HER4). This may result in the inhibition of cell growth and angiogenesis in tumors overexpressing these RTKs. EGFRs play major roles in both tumor cell proliferation and tumor vascularization, and are overexpressed in many cancer cell types." + }, + { + "input": "Concept: ovomucoid (Glycoproteins)", + "output": "Biologically Active Substance described as glycoprotein derived from egg white." + }, + { + "input": "Concept: Bacillaceae Fischer 1895 (Bacterium)", + "output": "something described as a taxonomic family of bacterium in the phylum Firmicutes that contains the notable genus Bacillus." + }, + { + "input": "Concept: CDC Group IVc-2 (Bacterium)", + "output": "Cupriavidus described as a species of aerobic, Gram negative, rod and coccus shaped bacterium assigned to the phylum Proteobacteria. This species is motile non-fermentative, oxidase and catalase positive, does not reduce nitrate and is indole negative. C. pauculus is found in water and has rarely been associated with human infection but may be considered pathogenic in immunocompromised individuals." + }, + { + "input": "Concept: 3-APCT (Organic Chemical)", + "output": "something described as a substance being studied in the treatment of cancer. It is a type of ribonucleotide reductase inhibitor." + }, + { + "input": "Concept: AKR7A2 protein (Oxidoreductase)", + "output": "Oxidoreductase described as aflatoxin B1 aldehyde reductase member 2 (359 aa, ~40 kDa) is encoded by the human AKR7A2 gene. This protein is involved in aldehyde metabolism." + }, + { + "input": "Concept: Non-Small Cell Cancer of the Lung (Non-small cell neoplasms malignant of the respiratory tract cell type specified)", + "output": "Malignant neoplasm of bronchus described as heterogeneous group of lung cancers which include epidermoid or squamous carcinomas, adenocarcinomas, and large cell carcinomas." + }, + { + "input": "Concept: NY-ESO-1 c259 T Cells (Antineoplastic Immune Cell)", + "output": "Allogeneic Lymphocyte described as genetically engineered human allogeneic T lymphocytes that are transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the cancer/testis antigen NY-ESO-1, with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo and introduction into the patient, the allogeneic T lymphocytes expressing NY-ESO-1-C259-specific TCR specifically target and bind to NY-ESO-1-overexpressing tumor cells. This may result in the specific cytotoxic T-lymphocyte (CTL) killing of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor-associated antigen (TAA), is expressed in normal testis and on the surface of various tumor cell types. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C150511\" active clinical trials using this agent." + }, + { + "input": "Concept: specific (Behavior descriptors)", + "output": "General adjectival modifier described as clearly and explicitly stated." + }, + { + "input": "Concept: 17p12-17p11.2 (Chromosome band)", + "output": "Chromosome band described as a chromosome band present on 17p" + }, + { + "input": "Concept: Melanoma of the Skin pM1d(1) TNM Finding v8 (Cutaneous Melanoma pM1d TNM Finding v8)", + "output": "Cutaneous Melanoma pM1d TNM Finding v8 described as cutaneous melanoma with distant metastasis to CNS with or without M1a, M1b, or M1c sites of disease. LDH level elevated." + }, + { + "input": "Concept: Genus Pongo (Ponginae)", + "output": "something described as a genus of orangutans in the family HOMINIDAE, comprising two species. Among the PRIMATES, the orangutan is second in size only to the gorilla (GORILLA GORILLA)." + }, + { + "input": "Concept: LIQUID CHROMATOGRAPHY, SALICYLATE (Medical Device)", + "output": "Medical Device described as a salicylate test system is a device intended to measure salicylates, a class of analgesic, antipyretic and anti-inflammatory drugs that includes aspirin, in human specimens. Measurements obtained by this device are used in diagnosis and treatment of salicylate overdose and in monitoring salicylate levels to ensure appropriate therapy." + }, + { + "input": "Concept: conversion of lysyl-tRNA to pyrrolysyl-tRNA (Pre-Translational Amino Acid Modification)", + "output": "something described as the modification process that results in the conversion of lysine, carried by a specialized lysine-accepting tRNA (possessing a CUA anticodon), to pyrrolysine (a lysine with an amide linkage to a (4R,5R)-4-substituted pyrroline-5-carboxylate)." + }, + { + "input": "Concept: Merino superbreed (Mammal)", + "output": "Domestic Sheep described as merino sheep breed group" + }, + { + "input": "Concept: Stability of mood (Personal health status)", + "output": "Personal health status described as appropriate adjustment of prevailing emotional tone in response to circumstances" + }, + { + "input": "Concept: CARDIOMYOPATHY, ONCOCYTIC (Cardiomyopathies)", + "output": "Heart described as a hamartomatous lesion of the sinoatrial node, atrioventricular node, and Purkinje fibers of the cardiac conducting system. It occurs predominantly in the first two years of life. Most patients present with arrhythmias and electrical disturbances. It is characterized by the presence of multifocal, poorly defined islands of large polygonal cells with a granular eosinophilic cytoplasm, a small round to oval-shaped nucleus, and occasional nucleoli. The cytoplasmic appearance is due to extensive accumulation of mitochondria. If left untreated, this condition is usually fatal. However, the outcome has improved over the past two decades due to developments in surgical intervention, electrophysiological mapping, and ablation of the arrhythmogenic foci, with a survival rate of approximately 80%." + }, + { + "input": "Concept: Eyelid weight, implantable (Ophthalmological device)", + "output": "Medical Device described as eyelid weights designed for implantation under the upper eyelid to provide additional weight. These devices are typically metal (e.g., gold, platinum) weights in a range from 0.5 to 3.0 grams that are surgically implanted under the upper eyelid, conforming to the curvature of the ocular sphere. Implantable eyelid weights are used in the treatment of partial facial paralysis in which the eye cannot be completely closed (i.e., lagophthalmos); their use reduces the risk of ocular exposure and improves the appearance of the face." + }, + { + "input": "Concept: DRRI1N12 (Intellectual Product)", + "output": "DRRI-2 Questionnaire Question described as deployment Risk & Resilience Inventory-2 - Since returning: I have experienced stressful legal problems (for example, being sued, suing someone else, or being in a custody battle)." + }, + { + "input": "Concept: Frank breech (Fetal Presentation)", + "output": "Fetal Presentation described as a kind of breech presentation in which the hips are flexed and the knees are extended." + }, + { + "input": "Concept: URETHRITIS GONOCOCCAL (Neisseria infection)", + "output": "Gonorrhea described as inflammation of the urethra secondary to infection with Neisseria gonorrhoeae; this infection is spread through sexual contact." + }, + { + "input": "Concept: Biological macromolecule (Anatomic structures)", + "output": "Substance described as anatomical structure, each instance of which has as its parts one or more ordered aggregates of some nucleotide, amino acid fatty acid or sugar molecules bonded to one another. Examples: collagen, DNA, neurotransmitter receptor, troponin." + }, + { + "input": "Concept: enzyme unit (Quantitative Concept)", + "output": "Quantitative Concept described as a unit of catalytic activity measurement defined as the quantity of a particular enzyme that catalyzes the transformation of one micromole of the substrate per minute under standard conditions for specified assay system. The usage of this unit is discouraged in favor of the katal by International Federation of Clinical Chemistry and Laboratory Medicine due to lack of its coherence with the SI system. One enzyme unit is equal to 16.667 nanokatals." + }, + { + "input": "Concept: (2S)-2-[(3-Amino-1-Oxopropyl)Amino]-3-(3-Methyl-4-Imidazolyl)Propanoic Acid (Amino acid derivative)", + "output": "Amino acid derivative described as a dipeptide comprised of a beta-alanine and a methylhistidine that is found in dietary red meat and has antioxidant activity." + }, + { + "input": "Concept: Colonoscopes (SCOPES AND CAMERAS)", + "output": "Digestive endoscope described as a fiber-optic device used to performed colonoscopy. A colonoscope is a 75-inch long flexible tube, with camera and a special attachment to snip off or cauterize polyps, and to perform biopsies on the colon and rectum." + }, + { + "input": "Concept: CSS01-Most Lethal Attempt Potential (C-SSRS Baseline Questionnaire Question)", + "output": "something described as columbia-Suicide Severity Rating Scale Baseline - Most lethal attempt potential lethality." + }, + { + "input": "Concept: SECRETION, DECREASED (Finding)", + "output": "Finding described as decrease in the amount of a secretory content present in the glandular lumen." + }, + { + "input": "Concept: ALG4 (Gene or Genome)", + "output": "something described as this gene is involved in RNA processing." + }, + { + "input": "Concept: IP Doc Comm Track (Intellectual Product)", + "output": "something described as subcategory name for the eTMF domain containing a collection investigational product (IP) and Trial Supplies documents, including communications, tracking, and documents not otherwise specified." + }, + { + "input": "Concept: Measurement of carcinoembryonic antigen (Chemical procedure)", + "output": "Laboratory Procedure described as a measurement of the carcinoembryonic antigen in a biological specimen." + }, + { + "input": "Concept: WHODAS 2.0 12-item Version Interviewer-administered - Concentrating for Ten Minutes (Intellectual Product)", + "output": "WHODAS 2.0 12-item Version Interviewer-administered Questionnaire Question described as world Health Organization Disability Assessment Schedule 2.0 12-item Version Interviewer-administered (WHODAS 2.0 12-item Version Interviewer-administered) In the past 30 days, how much difficulty did you have in: Concentrating on doing something for ten minutes?" + }, + { + "input": "Concept: Follicle inflamed (Disease or Syndrome)", + "output": "Hair Diseases described as inflammation of the hair follicles. Causes include excessive perspiration, skin infections, and skin wounds." + }, + { + "input": "Concept: ventral anterior-lateral complex of the thalamus (ventral group of the dorsal thalamus)", + "output": "something described as one of five substructures of the ventral group of the dorsal thalamus defined on the basis of connectivity and function in the rat ( Swanson-2004 ) and the mouse ( Hof-2000 ). (See Models Where It Appears below). In the classical segmentation of the thalamus it is equivalent to part of the ventral nuclear group located lateral and inferior to the anteroventral nucleus of the thalamus." + }, + { + "input": "Concept: NTC (Cell Component)", + "output": "something described as a protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p." + }, + { + "input": "Concept: Ethyl eosin (Organic Chemical)", + "output": "Indicator, Reagent, or Diagnostic Aid described as dye and chemical solution stains for medical purposes are mixtures of synthetic or natural dyes or nondye chemicals in solutions used in staining cells and tissues for diagnostic histopathology, cytopathology, or hematology." + }, + { + "input": "Concept: Giant Lambl Excrescence (Papillary muscle disorder)", + "output": "something described as a rare benign neoplasm of the endocardium. The vast majority of cases arise in the heart valves. Histopathologic examination reveals a papilloma lined by endothelial cells with a central avascular core which contains fibroblasts and elastic fibers. Patients may be asymptomatic or present with ischemic or embolic events." + }, + { + "input": "Concept: Substrate Specificity (Quantitative Concept)", + "output": "something described as a characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts." + }, + { + "input": "Concept: Abnormality of stem of antihelix (Anatomical Abnormality)", + "output": "something described as an abnormality of the stem of the antihelix, which is the part below the bifurcation of the antihelix into the inferior and superior crura." + }, + { + "input": "Concept: Toxicodendron Dermatitis (Disease or Syndrome)", + "output": "something described as an allergic contact dermatitis caused by exposure to plants of the genus Toxicodendron (formerly Rhus). These include poison ivy, poison oak, and poison sumac, all plants that contain the substance urushiol, a potent skin sensitizing agent." + }, + { + "input": "Concept: Salicaceae Mirb., 1815 (Angiosperm)", + "output": "Plant described as a plant family of the order MALPIGHIALES, superorder ROSANAE, class MAGNOLIOPSIDA. The leaves are alternate and simple, and staminate (male) flowers consist of one to several stamens; pistillate (female) flowers consist of a single-chambered ovary with several ovules that produce silky seeds." + }, + { + "input": "Concept: Stage IV Vulvar Cancer (Vulvar Cancer by AJCC v8 Stage)", + "output": "Vulvar Cancer by AJCC v8 Stage described as stage IV includes: T1-T3, N3, M0-M1. T1: Tumor confined to the vulva and/or perineum. Multifocal lesions should be designated as such. The largest lesion or the lesion with the greatest depth of invasion will be the target lesion identified to address the highest pT stage. Depth of invasion is defined as the measurement of the tumor from the epithelial-stromal junction of the adjacent most superficial dermal papilla to the deepest point of invasion. T2: Tumor of any size with extension to adjacent perineal structures (lower/distal third of the urethra, lower/distal third of the vagina, anal involvement). T3: Tumor of any size with extension to any of the following: upper/proximal two-thirds of the urethra, upper/proximal two-thirds of the vagina, bladder mucosa, or rectal mucosa; or fixed to pelvic bone. N3: Fixed or ulcerated regional lymph node metastasis. M0: No distant metastasis. M1: Distant metastasis (including pelvic lymph node metastasis)." + }, + { + "input": "Concept: Prognostic Marker (Biological Markers)", + "output": "Biological Markers described as genes and proteins for which the expression or presence of can help predict the course and outcome of a disease." + }, + { + "input": "Concept: En Bloc (General Qualifier)", + "output": "General Qualifier described as in a lump; as a whole; used to refer to autopsy techniques in which visceral organs are removed in large blocks allowing the prosector to retain a continuity in organ architecture during the subsequent dissection." + }, + { + "input": "Concept: proband (Family member)", + "output": "something described as the individual through whom a family with a genetic disorder is ascertained. In males this is called a propositus, and in females it is called a proposita." + }, + { + "input": "Concept: dendritic cell-targeting lentiviral vector ID-LV305 (Pharmacologic Substance)", + "output": "Antineoplastic Immune Cell described as an engineered lentiviral vector targeting dendritic cells (DCs) and containing nucleic acids encoding for the human tumor-associated cancer-testis antigen NY-ESO-1, with potential immunostimulatory and antineoplastic activities. Upon intradermal administration, the DC-targeting lentiviral vector ID-LV305 targets and binds to dermal DCs via the DC-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) receptor. Upon internalization of the vector, the NY-ESO-1 protein is expressed, stimulates DC maturation and activates the immune system to mount a cytotoxic T-lymphocyte (CTL) response against NY-ESO-1-expressing cells, which may result in tumor cell lysis. NY-ESO-1 is expressed in normal testes and on the surfaces of various tumor cells, and plays a key role in tumor cell proliferation and survival." + }, + { + "input": "Concept: histone methyltransferase complex location (methyltransferase complex)", + "output": "methyltransferase complex described as a multimeric complex that is able to catalyze the addition of methyl groups to histone proteins." + }, + { + "input": "Concept: Hour Times Milligram per Milliliter (Quantitative Concept)", + "output": "Measurement Unit Description described as hours times milligrams per milliliter." + }, + { + "input": "Concept: 1H-indole-3-acetamide, 6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1- piperazinyl]carbonyl]-N,N,1-trimethyl-alpha-oxo- (Mitogen-Activated Protein Kinase Inhibitor)", + "output": "Organic Chemical described as an orally bioavailable, small-molecule, p38 mitogen-activated protein kinase (MAPK) inhibitor with potential immunomodulating, anti-inflammatory, and antineoplastic activities. Talmapimod specifically binds to and inhibits the phosphorylation of p38 MAPK, which may result in the induction of tumor cell apoptosis, the inhibition of tumor cell proliferation, and the inhibition of tumor angiogenesis. This agent may also enhance proteasome inhibitor-induced apoptosis. p38 MAPK is a serine/threonine protein kinase involved in a MAPK signaling cascade that controls cellular responses to various environmental stresses, cytokines, and endotoxins." + }, + { + "input": "Concept: Activin Receptor-Like Kinases, Type I (Enzyme)", + "output": "Receptor described as one of the two types of ACTIVIN RECEPTORS or activin receptor-like kinases (ALK'S). There are several type I activin receptors. The major active ones are ALK-2 (ActR-IA) and ALK-4 (ActR-IB)." + }, + { + "input": "Concept: MAGE-A4-specific TCR gene-transduced C1032 T lymphocytes (T-cell Receptor-engineered T-cells)", + "output": "therapeutic autologous lymphocytes described as autologous human T-lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the human melanoma antigen A4 (MAGE-A4), with potential immunostimulatory and antineoplastic activities. Upon leukapheresis, isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous genetically-modified MAGE-A4 C1032 T cells bind to tumor cells expressing MAGE-A4. This may result in both inhibition of growth and increased cell death of MAGE-A4-expressing tumor cells. The tumor-associated antigen MAGE-A4, a member of the MAGE-A family of cancer testis antigens, is overexpressed by a variety of cancer cell types. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C138107\" active clinical trials using this agent." + }, + { + "input": "Concept: COLLECTOR, OSTOMY (Medical Device)", + "output": "Medical Device described as an ostomy pouch and accessories is a device that consists of a bag that is attached to the patient's skin by an adhesive material and that is intended for use as a receptacle for collection of fecal material or urine following an ileostomy, colostomy, or ureterostomy (a surgically created opening of the small intestine, large intestine, or the ureter on the surface of the body). This generic type of device and its accessories includes the ostomy pouch, ostomy adhesive, the disposable colostomy appliance, ostomy collector, colostomy pouch, urinary ileostomy bag, urine collecting ureterostomy bag, ostomy drainage bag with adhesive, stomal bag, ostomy protector, and the ostomy size selector, but excludes ostomy pouches which incorporate arsenic-containing compounds." + }, + { + "input": "Concept: positive regulation of T cell differentiation in thymus (Cell Function)", + "output": "positive regulation of T cell differentiation described as any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus." + }, + { + "input": "Concept: 17-Hydroxy-3-Oxo-19-Nor-17Alpha-Pregna-4,9-Diene-21-Nitrile (Genitourinary Agents)", + "output": "Progestins described as an orally-active, semisynthetic, fourth generation, nonethinylated progestogen with antiproliferative, antiandrogenic, anti-inflammatory and antiangiogenic activities that is used in hormone therapy and as a female contraceptive. Upon oral administration, dienogest binds intracellular progesterone receptors which then translocate to the nucleus where the drug-receptor complex interacts with progesterone response elements, thus altering the expression of target genes. Dienogest reduces the production of estradiol, prevents ovulation and alters the cervical mucus and endometrium. In addition, dienogest appears to suppress the expression of cell cycle regulator cyclin D1. Altogether, this may prevent the growth of endometrial epithelial cells and may reduce symptoms associated with leiomyoma." + }, + { + "input": "Concept: Paraiba (Brazilian State)", + "output": "Geographic Area described as a state in the Northeast Region of Brazil. Its capital is Joao Pessoa." + }, + { + "input": "Concept: S100 Calcium Binding Protein A12 wt Allele (S100A12 gene)", + "output": "something described as human S100A12 wild-type allele is located within 1q21 and is approximately 2 kb in length. This allele, which encodes S100-A12 protein, is involved in both cell cycle progression and differentiation and may be involved in calcium-dependent signal transduction pathways." + }, + { + "input": "Concept: aminoglycoside 2''-nucleotidyltransferase activity (Molecular Function)", + "output": "aminoglycoside nucleotidyltransferase activity described as catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + 2''-nucleotidylaminoglycoside." + }, + { + "input": "Concept: iohexol (ioxaglate meglumine)", + "output": "Benzoate derivative described as an X-ray contrast medium containing iohexol in various concentrations, from 140 to 350 milligrams of iodine per milliliter. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C65939\" active clinical trials using this agent." + }, + { + "input": "Concept: Cardiomegaly NOS (Heart failure)", + "output": "Myocardial Disorder described as increased size of the heart." + }, + { + "input": "Concept: regulation of thyroid hormone generation (regulation of nitrogen compound metabolic process)", + "output": "regulation of nitrogen compound metabolic process described as any process that modulates the frequency, rate or extent of thyroid hormone generation." + }, + { + "input": "Concept: Varicella-zoster virus antibody assay (Procedure to identify antibody)", + "output": "Specific antibody measurement described as a measurement of the total varicella zoster virus antibody in a biological specimen." + }, + { + "input": "Concept: TULAT (Organism Attribute)", + "output": "With laterality described as a qualifier for the side of the body the tumor identification assessment is performed." + }, + { + "input": "Concept: PARAMETRIUM (Fallopian tube, broad ligament, parametrium and parovarian region)", + "output": "Fallopian tube, broad ligament, parametrium and parovarian region described as mesentery, each instance of which is inferior part of some parametrium." + }, + { + "input": "Concept: Sengers Hamel Otten syndrome (Disease or Syndrome)", + "output": "Congenital Hydrocephalus described as syndrome with the association of congenital hydrocephalus, centripetal obesity, hypogonadism, intellectual deficit and short stature. It has been described in two males from one family. An X-linked recessive mode of inheritance was suggested." + }, + { + "input": "Concept: Suicidal ideation (Disturbance in content of thought)", + "output": "something described as a risk factor for suicide attempts and completions, it is the most common of all suicidal behavior, but only a minority of ideators engage in overt self-harm." + }, + { + "input": "Concept: positive regulation of cellodextrin metabolic process (positive regulation of carbohydrate metabolic process)", + "output": "positive regulation of macromolecule metabolic process described as any process that activates or increases the frequency, rate or extent of cellodextrin metabolic process." + }, + { + "input": "Concept: 3-hydroxyphenyl propanoate transport (organic hydroxy compound transport)", + "output": "Cell Function described as the directed movement of 3-hydroxyphenyl propanoate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." + }, + { + "input": "Concept: cellular response to gravitational stimulus (response to gravity)", + "output": "response to gravity described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus." + }, + { + "input": "Concept: Myofilament (Cell Component)", + "output": "Cell Component described as fibrillar protein polymers found in the contractile apparatus of muscle cells." + }, + { + "input": "Concept: Interventional Study Protocol Version Control Concurrency Type Code (Control Concurrency Type Code)", + "output": "something described as a coded value specifying the temporal relationships of the control to the study intervention. EXAMPLE(S): concurrent, historical, pre/post (patient owned control) OTHER NAME(S): NOTE(S):" + }, + { + "input": "Concept: NITROFURANTOIN (Nitrofurans)", + "output": "Nitrofurans described as a synthetic derivative of imidazolidinedione, Nitrofurantoin inhibits bacterial DNA, RNA, and cell wall protein synthesis. Activated by bacterial flavoproteins to intermediates that inactivate bacterial ribosomal proteins, Nitrofurantoin is used prophylactically as a urinary anti-infective agent against most gram-positive and gram-negative organisms and for long-term suppression of infections." + }, + { + "input": "Concept: Ophthalmic Sites Cancer TNM Finding v8 (Finding)", + "output": "Cancer TNM Finding by Site described as a finding about one or more characteristics of ophthalmic sites cancer, following the rules of the TNM AJCC v8 classification system." + }, + { + "input": "Concept: NUT Fusion Gene Positive (Rearrangement Detected)", + "output": "Laboratory or Test Result described as an indication that a NUTM1 fusion gene has been detected in a sample." + }, + { + "input": "Concept: Commands: Shoulder (ADAS-Cog CDISC Version Questionnaire Question)", + "output": "ADAS-Cog CDISC Version Questionnaire Question described as alzheimer's Disease Assessment Scale-Cognitive CDISC Version - Commands task for tap each shoulder twice with two fingers keeping your eyes shut." + }, + { + "input": "Concept: Clodronic acid-containing product (Organic Chemical)", + "output": "Pharmacologic Substance described as a first-generation bisphosphonate with anti-resorptive and anti-hypercalcemic activities. Clodronic acid adsorbs onto the surface of the hydroxyapatite crystals in bone matrix. Although the exact mechanism through which clodronic acid exerts its cytotoxic effect on osteoclasts has yet to be fully elucidated, this agent is metabolized intracellularly to a toxic beta-gamma-methylene analog of adenosine triphosphate (ATP), AppCCl2p. The ATP analog AppCCl2p competitively inhibits ADP/ATP translocase, thereby interfering with mitochondrial membrane potential and cellular energy metabolism. This may cause osteoclast apoptosis and, eventually, inhibiting osteoclast-mediated bone resorption." + }, + { + "input": "Concept: gibberellic acid metabolism (carboxylic acid metabolic process)", + "output": "Molecular Function described as the chemical reactions and pathways involving gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators." + }, + { + "input": "Concept: Certified Medical Assistant (Medical assistant)", + "output": "Professional or Occupational Group described as a medical assistant who has successfully completed an examination that earns them the credentials to become a certified medical assistant." + }, + { + "input": "Concept: Identifies as non-conforming gender (Gender identity finding)", + "output": "Finding described as an individual who does not subscribe to conventional gender distinctions but identifies with neither, both, or a combination of male and female genders." + }, + { + "input": "Concept: intralaminar nuclei (Body Part, Organ, or Organ Component)", + "output": "Body Part, Organ, or Organ Component described as a composite substructure of the thalamus that differs from the intralaminar nuclear group in that it excludes the parafascicular nucleus and includes the limitans nucleus of the posterior nuclear complex ( Crosby-1962 )." + }, + { + "input": "Concept: extracellular matrix constituent, lubricant activity (extracellular matrix structural constituent)", + "output": "extracellular matrix structural constituent described as functions as a lubricant for an extracellular matrix, such as a mucous membrane." + }, + { + "input": "Concept: TCR-specific, alpha fetoprotein-enhanced autologous T lymphocytes (Antineoplastic Immune Cell)", + "output": "Antineoplastic Immune Cell described as a preparation of human autologous T-lymphocytes transduced with a viral vector encoding for a T-cell receptor (TCR) specific for human alpha-fetoprotein (AFP), with potential antineoplastic activity. Following administration, the TCR-specific, alpha fetoprotein-enhanced autologous T-lymphocytes recognize and bind to AFP antigen-positive cells, which results in lysis and killing of AFP-positive cancer cells. AFP is overexpressed in a variety of cancers." + }, + { + "input": "Concept: BRAIN, FOREBRAIN (Brain part)", + "output": "Cardinal segment of brain described as part of the brain developed from the most rostral of the three primary vesicles of the embryonic neural tube (brain) from which the diencephalon and telencephalon are derived; also called the forebrain." + }, + { + "input": "Concept: iodoform (Homeopathic remedies letter I)", + "output": "Homeopathic remedies letter I described as iodoform." + }, + { + "input": "Concept: nicotinamide mononucleotide transport (carbohydrate derivative transport)", + "output": "cofactor transport described as the directed movement of nicotinamide mononucleotide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of D-ribose. It is a constituent of NAD and NADP." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Chlamydia Species (IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria)", + "output": "Medical Device described as molecular assay reagents intended to identify species of Chlamydia, a genus of intracellular bacteria of the family Chlamydiaceae, by detecting specific genetic information of the ribonucleic acid of the target bacteria. Chlamydia bacteria cause a variety of diseases in humans, including trachoma, inclusion conjunctivitis, and a variety of urogenital infections." + }, + { + "input": "Concept: indole acetic acid carboxyl methyltransferase activity (Molecular Function)", + "output": "something described as catalysis of the reaction: indole acetic acid + S-adenosyl-methionine = methyl indole acetic acid ester + S-adenosyl-homocysteine." + }, + { + "input": "Concept: Pulmonary hilum mass (Disorder of lower respiratory system)", + "output": "Disorder of lower respiratory system described as an abnormal growth located in the hilum of the lung." + }, + { + "input": "Concept: Minute Times Millimole per Milliliter (Measurement Unit Description)", + "output": "Quantitative Concept described as minutes times moles per liter (area under the curve)." + }, + { + "input": "Concept: Stage IVB Thyroid Gland Follicular Carcinoma AJCC v7 (Stage IV Thyroid Gland Follicular Carcinoma AJCC v7)", + "output": "Stage IVB Differentiated Thyroid Gland Carcinoma AJCC v7 described as stage IVB includes: T4b, Any N, M0. T4b: Very advanced disease. Tumor invades prevertebral fascia or encases carotid artery or mediastinal vessels. M0: No distant metastasis." + }, + { + "input": "Concept: Bone Marrow Blood-Forming Cells (Hematopoietic System)", + "output": "Cells described as cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells." + }, + { + "input": "Concept: monolayer-surrounded lipid storage body (Cell Component)", + "output": "Lipid droplet described as a subcellular organelle of plant cells surrounded by 'half-unit' or a monolayer membrane instead of the more usual bilayer. The storage body has a droplet of triglyceride surrounded by a monolayer of phospholipids, interacting with the triglycerides and the hydrophilic head groups facing the cytosol, and containing major protein components called oleosins." + }, + { + "input": "Concept: negative regulation of cell migration in other organism (negative regulation of cell migration)", + "output": "Biologic Function described as any process that stops, prevents, or reduces the frequency, rate or extent of cell migration in a second organism." + }, + { + "input": "Concept: London Deauville Criteria Point Scale 3 (Intellectual Product)", + "output": "something described as the results of the positron emission tomography are negative; the tracer uptake is greater than the mediastinum but less than or equal to the liver." + }, + { + "input": "Concept: Long chain fatty acid, NOS (FATTY ACIDS, LIPIDS AND LIPOPROTEINS)", + "output": "Fatty Acids described as fatty acid with 10 or more carbon atoms" + }, + { + "input": "Concept: FA Gene Mutation (Fanconi Anemia Complementation Group Gene Mutation)", + "output": "Fanconi Anemia Complementation Group Gene Mutation described as a change in the nucleotide sequence of the FANCA gene." + }, + { + "input": "Concept: Pediatric Nephrology Terminology (NICHD Terminology)", + "output": "something described as terminology developed by a collaborative effort of the National Cancer Institute's Enterprise Vocabulary Services, the National Institute of Child Health and Human Development, and an international group of clinicians and informaticists to support the reporting of events in the pediatric population with issues pertaining to nephrology." + }, + { + "input": "Concept: EGFR mutant-specific inhibitor CK-101 (Antineoplastic Enzyme Inhibitor)", + "output": "Antineoplastic Enzyme Inhibitor described as an orally available third-generation and selective inhibitor of certain epidermal growth factor receptor (EGFR) activating mutations, including the resistance mutation T790M, and the L858R and del 19 mutations, with potential antineoplastic activity. Upon administration, the EGFR mutant-specific inhibitor CK-101 specifically and covalently binds to and inhibits selective EGFR mutations, with particularly high selectivity against the T790M mutation, which prevents EGFR mutant-mediated signaling and leads to cell death in EGFR mutant-expressing tumor cells. Compared to some other EGFR inhibitors, CK-101 may have therapeutic benefits in tumors with T790M-mediated drug resistance. This agent shows minimal activity against wild-type EGFR (WT EGFR), and does not cause dose-limiting toxicities that occur during the use of non-selective EGFR inhibitors, which also inhibit WT EGFR. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization." + }, + { + "input": "Concept: FAC00815 (FACT-C Version 4 Questionnaire Question)", + "output": "Intellectual Product described as functional Assessment of Cancer Therapy-Colorectal Version 4 (FACT-C Version 4) Emotional Well-Being: I feel sad." + }, + { + "input": "Concept: Hypo-and hypermelanotic cutaneous macules, retarded growth, intellectual disability syndrome (Genetic disorder of skin pigmentation)", + "output": "Congenital pigmentary skin anomalies described as a neurocutaneous syndrome with characteristics of congenital hypomelanotic and hypermelanotic cutaneous macules. It has been described in individuals spanning three generations of an Indian family. Some of the patients also had retarded growth and intellectual deficit." + }, + { + "input": "Concept: Critical Care Outcome (Outcome Assessment, Health Care)", + "output": "something described as a measure of the mortality and morbidity rates among patients who receive CRITICAL CARE and INTENSIVE CARE as determined from the date of hospital discharge or release." + }, + { + "input": "Concept: HAEMATOMA (BLOOD CLOTS AND HEMATOMAS)", + "output": "something described as a large, localized, space-occupying collection of extravasated blood in a tissue or organ." + }, + { + "input": "Concept: HTLV I Infections (Non-Cancer Diagnosis)", + "output": "Infection caused by Human T-lymphotropic virus described as diseases caused by HUMAN T-LYMPHOTROPIC VIRUS 1." + }, + { + "input": "Concept: Fowler's syndrome (Urinary Retention)", + "output": "Functional disorder of bladder neck and sphincter mechanism described as characterised by urinary retention associated with abnormal electromyographic activity in young women in the absence of overt neurologic disease. May also be associated with polycystic ovaries in some women." + }, + { + "input": "Concept: Cor triatrium sinister (Cor Triatriatum)", + "output": "Congenital Abnormality described as a developmental anomaly of the heart characterized by the presence of three atria because the left atrium is divided by an abnormal septum." + }, + { + "input": "Concept: Kaufman assess battery, childr (Assessment scales)", + "output": "Intelligence Tests described as a clinical tool used to assess a child's strengths and weaknesses in cognitive ability and mental processing." + }, + { + "input": "Concept: WHI (Intellectual Product)", + "output": "Component of the National Institutes of Health described as a major 15-year research program launched in 1991 to address the most common causes of death, disability and poor quality of life in postmenopausal women, focusing on cardiovascular disease, cancer, and osteoporosis." + }, + { + "input": "Concept: fluorine F 18 5-fluoro-2-deoxycytidine (Pharmacologic Substance)", + "output": "something described as a radioconjugate composed of a fluorinated pyrimidine analog, linked to the radioisotope fluorine F 18 with potential imaging activity using positron emission tomography/computed tomography (PET/CT). Upon administration of fluorine F 18 5-fluoro-2-deoxycytidine ([F-18]-FdCyd), the FdCyd moiety is phosphorylated by deoxycytidine kinase to 5-fluoro-2'-deoxycytidylate (FdCMP) and deaminated by deoxycytidylate (dCMP) deaminase, an enzyme overexpressed by tumor cells, to 5-fluoro-2-deoxyuridine monophosphate (FdUMP). Eventually, FdUMP is metabolized to the triphosphate forms 5-fluoro-2'-deoxycytidine-triphosphate (FdCTP) and fluorodeoxyuridine triphosphate (FdUTP). FdCTP and FdUTP inhibit DNA methyltransferase (DNMT) and DNA methylation, and induce DNA strand breaks, respectively. FdCyd is coadministered with tetrahydrouridine (THU), an inhibitor of cytidine/deoxycytidine deaminase, which prevents FdCyd breakdown and increases its efficacy. The fluorine F 18 moiety can be imaged upon PET/CT, thereby allowing for the evaluation of the biodistribution of FdCyd and its uptake by tumor cells." + }, + { + "input": "Concept: clover red (Flower Essences)", + "output": "Pharmacologic Substance described as red clover, meadow honeysuckle." + }, + { + "input": "Concept: Malta (Country)", + "output": "Geographic Area described as a country in Southern Europe, occupying islands in the Mediterranean Sea, south of Sicily (Italy)." + }, + { + "input": "Concept: HALLUX VARUS AND PREAXIAL POLYSYNDACTYLY (Congenital anomaly of bone and joint)", + "output": "something described as a rare genetic congenital limb malformation disorder with characteristics of bilateral medial displacement of the hallux and preaxial polysyndactyly of the first toes. Radiographs show broad, shortened, misshapen first metatarsals and may associate incomplete or complete duplication of proximal phalanges and duplication or triplication of distal phalanges. There have been no further descriptions in the literature since 1980." + }, + { + "input": "Concept: Tomographies (Neuroimaging)", + "output": "Diagnostic radiologic examination described as imaging methods that result in sharp images of objects located on a chosen plane and blurred images located above or below the plane." + }, + { + "input": "Concept: CSS1116A (Intellectual Product)", + "output": "C-SSRS Lifetime/Recent Version Questionnaire Question described as columbia-Suicide Severity Rating Scale Lifetime/Recent Version - Total number of interrupted attempts. (Lifetime)." + }, + { + "input": "Concept: Intergroup Rhabdomyosarcoma Group II (Intergroup Rhabdomyosarcoma Clinical Group Extent of Disease)", + "output": "Intellectual Product described as total gross resection with regional disease spread." + }, + { + "input": "Concept: OCA-B protein, human (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as POU domain class 2-associating factor 1 (256 aa, ~27 kDa) is encoded by the human POU2AF1 gene. This protein is involved in both the modulation of transcription and humoral immunity." + }, + { + "input": "Concept: Stage I Rectal Cancer (Rectal Cancer by AJCC v6 Stage)", + "output": "Rectal Cancer by AJCC v6 Stage described as stage I includes: (T1, N0, M0); (T2, N0, M0). T1: Tumor invades submucosa. T2: Tumor invades muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis." + }, + { + "input": "Concept: Intravenous Care (rnix hemodynamic care)", + "output": "Infusion care described as actions performed to support the use of infusion equipment" + }, + { + "input": "Concept: Passos-Bueno syndrome (Autosomal recessive hereditary disorder)", + "output": "Occipital Encephalocele described as mental retardation, hypotonicity, incontinence, muscle atrophy, and inability to walk or speak originally reported in 7 males in 2 generations." + }, + { + "input": "Concept: Embryo CS10 (Embryonic Structure)", + "output": "something described as discrete temporal embryo between 26-28 days postovulation." + }, + { + "input": "Concept: Uterine Corpus Myxoid Leiomyosarcoma (Leiomyosarcoma, Myxoid)", + "output": "something described as a morphologic variant of leiomyosarcoma arising from the uterus corpus. It is characterized by the presence of cellular pleomorphism, malignant cells with large nuclei, and a myxoid stroma." + }, + { + "input": "Concept: HEXOKINASE, GLUCOSE (Indicator, Reagent, or Diagnostic Aid)", + "output": "something described as a glucose test system is a device intended to measure glucose quantitatively in blood and other body fluids. Glucose measurements are used in the diagnosis and treatment of carbohydrate metabolism disorders including diabetes mellitus, neonatal hypoglycemia, and idiopathic hypoglycemia, and of pancreatic islet cell carcinoma." + }, + { + "input": "Concept: Absent 5th metatarsals (Finding)", + "output": "Foot described as a developmental abnormality characterized by the absence of the fifth metatarsal bone." + }, + { + "input": "Concept: HNRNPK Gene (Ligand Binding Protein Gene)", + "output": "something described as this gene is involved in binding to poly-cytidine sequences in pre-mRNA and single-stranded DNA." + }, + { + "input": "Concept: Co infection (Communicable Diseases)", + "output": "Parasitic Diseases described as simultaneous infection of a host organism by two or more pathogens. In virology, coinfection commonly refers to simultaneous infection of a single cell by two or more different viruses." + }, + { + "input": "Concept: Coral Reefs (Ecosystem)", + "output": "Natural Phenomenon or Process described as marine ridges composed of living CORALS, coral skeletons, calcareous algae, and other organisms, mixed with minerals and organic matter. They are found most commonly in tropical waters and support other animal and plant life." + }, + { + "input": "Concept: Autism Spectrum Disorder Gene Panel Reagents (IVD Panels, Human Genetics, Encephalopathy)", + "output": "IVD Panels, Human Genetics, Encephalopathy described as molecular assay reagents intended to identify gene variants associated with autism spectrum disorder, a collection of conditions that exhibit deficits in social communication and interaction and restricted and/or repetitive behavioral patterns, interests, and activities. Genetic variants at multiple loci have been associated with autism spectrum disorder. These reagents are intended to detect various types of genetic changes (e.g., deletions, duplications, insertions, single nucleotide polymorphisms) in multiple autism spectrum disorder-associated loci simultaneously." + }, + { + "input": "Concept: adult diffuse small cleaved cell lymphoma, stage I (Adult Diffuse Small Cleaved Cell Lymphoma)", + "output": "something described as stage I: Involvement of a single lymph node region (I) or localized involvement of a single extralymphatic organ or site (IE). (from PDQ) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C8075\" active clinical trials using this agent." + }, + { + "input": "Concept: Difficulty walking backward (Gait abnormality)", + "output": "something described as reduced ability to walk (ambulate) in a backwards direction." + }, + { + "input": "Concept: Anesthesia for Obstetric Procedures (Therapeutic or Preventive Procedure)", + "output": "Therapeutic or Preventive Procedure described as a variety of anesthetic methods such as EPIDURAL ANESTHESIA used to control the pain of childbirth." + }, + { + "input": "Concept: Atypical Lymphocyte to Leukocyte Ratio Measurement (Blood Cell Count Ratio Measurement)", + "output": "something described as a relative measurement (ratio or percentage) of the atypical lymphocytes to leukocytes in a biological specimen." + }, + { + "input": "Concept: glycerol-3-phosphate dehydrogenase complex (oxidoreductase complex)", + "output": "Cell Component described as an enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate." + }, + { + "input": "Concept: Aluminum element (Elements, Ions and Simple Compounds)", + "output": "Element or Ion described as a metallic element in the boron group with atomic symbol Al, atomic number 13, and atomic weight 27." + }, + { + "input": "Concept: CARUM CARVI WHOLE (Carum)", + "output": "Plant described as caraway." + }, + { + "input": "Concept: himalaya proselect glucosim (Clinical Drug)", + "output": "something described as himalaya ProSelect(TM) Glucosim 120, 500 mg tablets. UPC Code 605069109017." + }, + { + "input": "Concept: 11-oxo-beta-amyrin metabolism (pentacyclic triterpenoid metabolic process)", + "output": "cellular ketone metabolic process described as the chemical reactions and pathways involving 11-oxo-beta-amyrin." + }, + { + "input": "Concept: g/mL/(ug/m2/d) (Unit of concentration)", + "output": "something described as grams per milliliter (concentration), divided by micrograms per meter squared per day (daily dose normalized by surface area)." + }, + { + "input": "Concept: Saponin-Cholesterol-Phospholipid Adjuvant (Vaccine Adjuvant)", + "output": "Pharmacologic Substance described as an adjuvant comprised of saponin, derived from the bark of Quillaia saponaria Molina, cholesterol and phospholipid with antigen-delivery and immunostimulatory activities. This saponin-based adjuvant in combination with various antigens, including those for human papilloma virus (HPV), hepatitis C virus (HCV), and the human cancer antigen NY-ESO-1, may result in potent antibody, CD4+ T-helper-cell, and CD8+ cytotoxic T-cell responses against the targeted antigen. In addition, this agent may reduce the amount of antigen necessary to induce an efficient immune response in the host. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C53436\" active clinical trials using this agent." + }, + { + "input": "Concept: ACEPHALOSTOMIA (Disorder of head)", + "output": "Congenital Abnormality described as absence of the head but with the presence of mouth-like orifice in the neck region. (Makris S, Solomon HM, Clark R, Shiota K, Barbellion S, Buschmann J, Ema M, Fujiwara M, Grote K, Hazelden KP, Hew KW, Horimoto M, Ooshima Y, Parkinson M, Wise LD. Terminology of developmental abnormalities in common laboratory mammals (Version 2). Part B. Birth Defects Res B Dev Reprod Toxicol. 2009 Aug;86(4):227-327.)" + }, + { + "input": "Concept: cardiac stimulants (Inotropic agent)", + "output": "Cardiovascular Agents described as agents that have a strengthening effect on the heart or that can increase cardiac output." + }, + { + "input": "Concept: Use Sedative or Sleeping Medication Not as Prescribed or Without a Prescription (Clinical or Research Assessment Question)", + "output": "something described as a question about whether an individual uses or used a sedative or sleeping medication not as prescribed or without a prescription." + }, + { + "input": "Concept: carbon-nitrogen ligase activity, with glutamine as amido-N-donor (Molecular Function)", + "output": "Molecular Function described as catalysis of the transfer of the amide nitrogen of glutamine to a substrate. Usually composed of two subunits or domains, one that first hydrolyzes glutamine, and then transfers the resulting ammonia to the second subunit (or domain), where it acts as a source of nitrogen." + }, + { + "input": "Concept: Abnormal circulating gonadotropin level (Finding)", + "output": "Abnormal circulating hormone level described as an anomaly of the circulating level of a gonadotropin, that is, of a protein hormone secreted by gonadotrope cells of the anterior pituitary of vertebrates. The primary gonadotropins are luteinizing hormone (LH) and follicle-stimulating hormone (FSH)." + }, + { + "input": "Concept: Egg Preservation (Biologic Sample Preservation Procedure)", + "output": "something described as methods for preserving egg cells such as oocyte cryopreservation in liquid nitrogen." + }, + { + "input": "Concept: Uterine Papillary Serous Carcinoma (Uterine Neoplasms)", + "output": "Serous Cystadenocarcinoma described as a high grade, aggressive adenocarcinoma arising from the endometrium. It is characterized by the presence of complex papillary patterns with cellular budding. Atypical mitoses, necrosis, and psammoma bodies may be present. It is classified as type II endometrial carcinoma and it is not associated with endometrial hyperplasia. It tends to invade deeply into the myometrium and spreads into the lymphatic vessels. Patients frequently present with spread of the tumor beyond the uterus at the time of diagnosis. The prognosis is usually poor." + }, + { + "input": "Concept: Multilocular peritoneal inclusion cyst (Peritoneal Mesothelioma)", + "output": "Peritoneal Mesothelioma described as a rare benign tumor characterized by the formation of intra-abdominal multilocular cystic masses. It occurs more frequently in women of child-bearing age. In women, the masses are generally located on the peritoneal surface of the uterus and rectum, while in men they are generally located on the peritoneal surface of the bladder and rectum. The tumor can also spread into the upper portions of the peritoneal cavity. Appears to originate from the peritoneal mesothelium.There is no relation with asbestos exposure. Invasive or malignant progression has been described." + }, + { + "input": "Concept: regulation of macrophage antigen processing and presentation (regulation of antigen processing and presentation)", + "output": "regulation of antigen processing and presentation described as any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation." + }, + { + "input": "Concept: Fallopian Tube Cancer pTX TNM Finding v7 (Finding)", + "output": "Fallopian Tube Cancer Pathologic Primary Tumor TNM Finding v7 described as fallopian tube cancer in which the primary tumor cannot be assessed." + }, + { + "input": "Concept: CYP2C19*12 (Gene or Genome)", + "output": "something described as human CYP2C19*12 allele is located within 10q24.1-q24.3 and is approximately 90 kb in length. This allele, a variant form of the CYP2C19 wild-type allele, encodes cytochrome P450 2C19*12 protein. The CYP2C19*12 allele exhibits a clinically-relevant SNP (c.1473A>C) in exon 9 that results in a X491C coding change. This alteration yields an unstable cytochrome P450 2C19*12 protein that is predicted to have an additional 26 amino acids." + }, + { + "input": "Concept: Alpha Particle Emitter (Physical Phenomenon or Property)", + "output": "Element, Ion, or Isotope described as unstable isotopes of high atomic number (elements of mass number from 82 up) which energetically release from their nuclei a particle consisting of two neutrons and two protons, with a positive charge (2e+) and identical to the helium nucleus." + }, + { + "input": "Concept: olive oil/soybean oil/multi-amino acid/glucose parenteral nutrition emulsion (Dietary Supplements)", + "output": "something described as an electrolyte-based parenteral emulsion for infusion consisting of a three chamber bag system containing a glucose solution, an amino acid solution and a lipid emulsion that can be used to provide parenteral nutritional supplementation. The lipid emulsion portion contains 20% refined soybean oil and 80% refined olive oil; the amino acid solution contains alanine, arginine, aspartic acid, glutamic acid, leucine, isoleucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, and valine. The parenteral nutrition emulsion also contains the electrolytes phosphate and acetate. The three separate bags are mixed together before infusion. Upon infusion, the emulsion provides calories for energy. The lipid portion supplies essential fatty acids that can be incorporated into cell membranes. The amino acids facilitate protein synthesis." + }, + { + "input": "Concept: Grade 3 Hepatitis B reactivation (Finding)", + "output": "Finding described as severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; IV intervention indicated" + }, + { + "input": "Concept: peripheral retinal neovascularization (Retinal Neovascularization)", + "output": "Retinal Neovascularization described as a type of retinal neovascularization that affects the periphery of the retina." + }, + { + "input": "Concept: Pigmented nevus of skin (Hamartoma of skin)", + "output": "Nevus described as a nevus characterised by the presence of excessive pigment." + }, + { + "input": "Concept: Pain of breast (Pain finding at anatomical site)", + "output": "Esthesia described as painful sensation in the breast region." + }, + { + "input": "Concept: Film-Coated Tablet and Gastro-Resistant Granules in Sachet (Dosage Form and Package Type)", + "output": "something described as medicinal product consisting of a film-coated tablet and gastro-resistant granules presented together in a sachet and intended to be swallowed together as a single dose. If two or more tablets are present to make up the dose, the term 'Film-coated tablets and gastro-resistant granules in sachet' is used." + }, + { + "input": "Concept: Neoplasm of Urinary System (Mass of urogenital structure)", + "output": "Mass of urinary system structure described as tumors or cancer of the URINARY TRACT in either the male or the female." + }, + { + "input": "Concept: MCOPS6 (BMP4 gene)", + "output": "BMP4 gene described as human BMP4 wild-type allele is located within 14q22-q23 and is approximately 7 kb in length. This allele, which encodes bone morphogenetic protein 4, plays a role in cartilage and bone formation, mesoderm induction, tooth development, and limb formation. Mutation of the gene is associated with microphthalmia syndromic type 6 and non-syndromic orofacial cleft type 11." + }, + { + "input": "Concept: Phobia management assistance individual each 15 minutes (mental health counseling)", + "output": "Therapeutic or Preventive Procedure described as using counseling techniques to assist a client in developing coping techniques to manage the cognitive, behavioral and emotional symptoms of his or her phobia. Service is billed in 15-minute increments." + }, + { + "input": "Concept: Have Difficulty Reading Because of Vision (Intellectual Product)", + "output": "Clinical or Research Assessment Question described as a question about whether an individual has or had difficulty reading because of vision." + }, + { + "input": "Concept: Pain Crisis (Finding of present pain intensity)", + "output": "Finding described as an event in which the patient reports pain that is severe, uncontrolled, and causing distress for the patient, family members, or both." + }, + { + "input": "Concept: Iris Melanoma pT1b TNM Finding v8 (Finding)", + "output": "Iris Melanoma pT1 TNM Finding v8 described as iris melanoma with tumor limited to the iris, more than 3 clock hours in size." + }, + { + "input": "Concept: Nephrotic Syndrome - WT1 Associated (Disease or Syndrome)", + "output": "Disease or Syndrome described as nephrotic syndrome attributed to mutation(s) in the WT1 gene." + }, + { + "input": "Concept: Grade 1 Periodontal Disease, CTCAE (Periodontal Disease, CTCAE)", + "output": "Periodontal Disease, CTCAE described as gingival recession or gingivitis; limited bleeding on probing; mild local bone loss" + }, + { + "input": "Concept: 1-sulfanilyl-2-thiourea (Antibiotic)", + "output": "something described as a short-acting sulfonamide antibiotic." + }, + { + "input": "Concept: Airway Management (Therapeutic procedure)", + "output": "Common nursing interventions II described as evaluation, planning, and use of a range of procedures and airway devices for the maintenance or restoration of a patient's ventilation." + }, + { + "input": "Concept: Forgiveness assistance individual each 15 minutes (Psychosocial procedure)", + "output": "Coping Assistance described as assisting an individual's willingness to replace feelings of anger and resentment toward another, self, or higher power, with beneficence, empathy, and humility" + }, + { + "input": "Concept: Myelosis-non-leukaemic (WHITE CELL AND RES DISORDERS)", + "output": "PLATELET,BLEEDING & CLOTTING DISORDERS described as a partial or complete replacement of the bone marrow stroma by fibrous tissue. It can be a primary bone marrow lesion as part of the chronic myeloproliferative disorders (chronic idiopathic myelofibrosis), a manifestation of acute myeloid leukemia (acute panmyelosis with myelofibrosis), or a secondary phenomenon due to bone marrow involvement by a metastatic tumor (e.g., metastatic breast carcinoma). --2003" + }, + { + "input": "Concept: Confirm AJCC/TNM Cancer Staging Edition (Form Directive)", + "output": "Occupational Activity described as a directive to confirm the relevant edition of the AJCC/TNM Cancer Staging Edition." + }, + { + "input": "Concept: Esophageal swallowing (Organ or Tissue Function)", + "output": "Deglutition described as function of clearing food and drink through the oesophagus at an appropriate rate and speed." + }, + { + "input": "Concept: Global Rating of Change in Joint Pain and Stiffness Questionnaire (Clinical or Research Assessment Questionnaire)", + "output": "Clinical or Research Assessment Questionnaire described as a questionnaire designed to measure joint pain and stiffness over a 36 month period." + }, + { + "input": "Concept: Ureteral Anastomotic Leak (Pathologic Function)", + "output": "Urinary Tract Anastomotic Leakage described as urinary leak specific to a reimplanted ureter." + }, + { + "input": "Concept: betulic acid (Organic Chemical)", + "output": "Organic Chemical described as a pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) with antiinflammatory, anti-HIV and antineoplastic activities. Betulinic acid induces apoptosis through induction of changes in mitochondrial membrane potential, production of reactive oxygen species, and opening of mitochondrial permeability transition pores, resulting in the release of mitochondrial apogenic factors, activation of caspases, and DNA fragmentation. Although originally thought to exhibit specific cytotoxicity against melanoma cells, this agent has been found to be cytotoxic against non-melanoma tumor cell types including neuroectodermal and brain tumor cells." + }, + { + "input": "Concept: Metalloexopeptidases (Enzyme)", + "output": "Amino Acid, Peptide, or Protein described as EXOPEPTIDASES which use a metal such as ZINC in the catalytic mechanism." + }, + { + "input": "Concept: somatic dysfunction of lower extremities (nonallopathic lesion of lower extremities)", + "output": "nonallopathic lesion of lower extremities described as impaired or altered function of the lower extremity." + }, + { + "input": "Concept: honey flavor (Structured Product Labeling Flavor)", + "output": "Food described as a characteristic of a medicinal product, specifying that its most predominant agreeable savor detected by the unified sensation of taste and olfactory receptors resembles honey." + }, + { + "input": "Concept: GPI anchor release (GPI anchor metabolic process)", + "output": "something described as the GPI anchor metabolic process that results in enzymatic cleavage of the anchor, releasing an anchored protein from the membrane." + }, + { + "input": "Concept: Breast Cancer cM1 TNM Finding v7 (Breast Cancer Clinical Distant Metastasis TNM Finding v7)", + "output": "Finding described as breast cancer with distant detectable metastases as determined by classic clinical and radiographic means and/or histologically proven larger than 0.2 mm." + }, + { + "input": "Concept: (2E)-N-(4-(1-Benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)prop-2-enamide (Enzyme Inhibitor Drugs)", + "output": "Angiogenesis Inhibitors described as a small molecule with potential antineoplastic and antiangiogenic activities. Daporinad binds to and inhibits nicotinamide phosphoribosyltransferase (NMPRTase), inhibiting the biosynthesis of nicotinamide adenine dinucleotide (NAD+) from niacinamide (vitamin B3), which may deplete energy reserves in metabolically active tumor cells and induce tumor cell apoptosis. In addition, this agent may inhibit tumor cell prioduction of vascular endothelial growth factor (VEGF), resulting in the inhibition of tumor angiogenesis. The coenzyme NAD+ plays an essential role in cellular redox reactions, including the redox reaction linking the citric acid cycle and oxidative phosphorylation. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C67043\" active clinical trials using this agent." + }, + { + "input": "Concept: Material Deformation (Finding)", + "output": "Finding described as problem associated with an undesired material change in shape or property caused by external forces." + }, + { + "input": "Concept: Untreated Childhood Myeloid Neoplasm (Untreated Hematopoietic and Lymphoid Cell Neoplasm)", + "output": "Myeloid Neoplasm Finding described as a finding of myeloid neoplasm in childhood that has not been treated." + }, + { + "input": "Concept: Osteocalcin (Laboratory Procedure)", + "output": "SPECIFIC SUBSTANCE CHEMISTRY TESTS described as a measurement of the osteocalcin in a biological specimen." + }, + { + "input": "Concept: Capitate (Bone structure of carpus)", + "output": "Bone structure of distal carpus described as a carpal bone with a rounded head located between the TRAPEZOID BONE and the HAMATE BONE." + }, + { + "input": "Concept: 4-fumarylacetoacetate fumarylhydrolase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+)." + }, + { + "input": "Concept: ADL0327 (Intellectual Product)", + "output": "something described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, MCI (ADCS-ADL MCI) Subscore for page 2. (Range = 0-8)." + }, + { + "input": "Concept: Performed Observation Target Anatomic Site Laterality Code (Intellectual Product)", + "output": "Target Anatomic Site Laterality Code described as a coded value specifying the side of the body (or a paired organ) that is a target site for an observation. EXAMPLE(S): bilateral, left, right" + }, + { + "input": "Concept: Voltage Gated K+ Channel KCNQ3 (Biologically Active Substance)", + "output": "something described as a very slow opening and closing voltage-gated potassium channel that is expressed in NEURONS and is closely related to KCNQ2 POTASSIUM CHANNEL. It is commonly mutated in BENIGN FAMILIAL NEONATAL CONVULSIONS." + }, + { + "input": "Concept: Tumor of Adult Choroid Plexus (Choroid Plexus Neoplasms)", + "output": "Choroid Plexus Neoplasms described as a neoplasm of the choroid plexus occurring in adults." + }, + { + "input": "Concept: AJCC Cancer Staging Manual 7th Edition (Clinical Classification)", + "output": "something described as AJCC TNM Staging System 7th Edition (AJCC V7) (Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A, editors. AJCC cancer staging manual (7th ed). New York, NY: Springer; 2010)." + }, + { + "input": "Concept: Invasive Micropapillary Serous Carcinoma of the Peritoneum (Neoplastic Process)", + "output": "Neoplastic Process described as a serous adenocarcinoma that arises from the lining of the peritoneum. It is characterized by low grade histopathologic features." + }, + { + "input": "Concept: Congenital dislocation, NOS (Congenital anomaly of bone and joint)", + "output": "Congenital malposition, NOS described as dislocation present at birth" + }, + { + "input": "Concept: sulfathiazole transmembrane transport (sulfur compound transport)", + "output": "sulfur compound transport described as the directed movement of sulfathiazole across a membrane." + }, + { + "input": "Concept: Wingless-Type MMTV Integration Site Family Negative (Expression Negative)", + "output": "Laboratory or Test Result described as an indication that the expression of Wnt family members has not been detected in a sample." + }, + { + "input": "Concept: Impedance cardiograph (Medical Device)", + "output": "something described as cardiographs designed for recording the variations of the thoracic electrical impedance caused by the activity of the heart muscle and its effect on the blood flow in the aorta, usually detected at the body surface. These instruments consist of a main unit that includes a high-frequency (e.g., 100 kHz) RF generator, a recorder, and typically a set of four detachable leads with electrodes attached at the distal tips. Two electrodes are placed on the neck and other two on the thoracic surface; one electrode of each pair delivers a low-intensity current of constant amplitude from the generator through the body. The other two electrodes sense the voltage variations that are proportional to the thoracic impedance variations, mainly due to the blood flow in the aorta. The values of the variations of the impedance and the graphic representation of the impedance and its first derivative versus time (i.e., impedance cardiograms) are used for calculation of hemodynamic parameters, such as cardiac output and stroke volume." + }, + { + "input": "Concept: IgIV (Amino Acid, Peptide, or Protein)", + "output": "Immunologic Factor described as a blood product derived from pooled IgG antibodies extracted from donor plasma delivered parenterally. It is used to treat multiple disorders, including immunodeficiencies, autoimmune disorders, and active infections." + }, + { + "input": "Concept: semaphorin-plexin signaling pathway involved in dendritic guidance (Molecular Function)", + "output": "semaphorin-plexin signaling pathway involved in neuron projection guidance described as any semaphorin-plexin signaling pathway that is involved in dendrite guidance." + }, + { + "input": "Concept: WD4D1 6 (WHODAS 2.0 12 24-item Version Interviewer-administered Questionnaire Question)", + "output": "Intellectual Product described as world Health Organization Disability Assessment Schedule 2.0 12+24-item Version Interviewer-administered (WHODAS 2.0 12+24-item Version Interviewer-administered) In the past 30 days, how much difficulty did you have in: Starting and maintaining a conversation?" + }, + { + "input": "Concept: T cell apoptotic process (Lymphocyte Apoptotic Process)", + "output": "Lymphocyte Apoptotic Process described as any apoptotic process in a T cell, a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." + }, + { + "input": "Concept: Histone 2 (Amino Acid, Peptide, or Protein)", + "output": "something described as proteins in the core histone families, histone H2A and histone H2B represent 2 of the 4 families of histones found in the core of nucleosomes. Histones in the H2A family dimerize with those in the H2B family, then two H2A/H2B dimers can associate with a tetramer containing 2 proteins from the histone H3 family and 2 proteins from the histone H4 family to form the octameric nucleosome core. The octameric complex is the basic unit for eukaryotic DNA packaging." + }, + { + "input": "Concept: platelet alpha granule lumen (secretory granule lumen)", + "output": "Cell Component described as the volume enclosed by the membrane of the platelet alpha granule." + }, + { + "input": "Concept: Version Date (Date in time)", + "output": "Date in time described as the date (and time) on which an entity is versioned." + }, + { + "input": "Concept: Daptomycin product (Lipopeptides)", + "output": "Cyclic lipopeptide antibiotic product described as a cyclic lipopeptide antibiotic that inhibits GRAM-POSITIVE BACTERIA." + }, + { + "input": "Concept: No known exposure to Ebola virus (Finding with explicit context)", + "output": "No history of clinical finding in subject described as a person with no known exposure to Ebola virus. This includes anyone who has been in a country in which an EVD outbreak occurred within the past 21 days and has had no high or low risk exposures to the Ebola virus." + }, + { + "input": "Concept: detection of oxidative stress (response to oxidative stress)", + "output": "Cell Function described as the series of events in which a stimulus indicating oxidative stress is received and converted into a molecular signal." + }, + { + "input": "Concept: trophectoderm cell differentiation (Cell Differentiation process)", + "output": "Cell Differentiation process described as the process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell." + }, + { + "input": "Concept: Eyeglass Lens Strain Detectors (Detectors, Strain)", + "output": "Detectors described as detectors designed to sense the deformation produced in an object by an applied force (i.e., strain). These detectors determine the presence of strain and also if it is beyond some pre-established limit, but usually do not measure accurately the intensity of the strain. Strain detectors are based in the change of some characteristic of a physical property of a sensor due to the strain, such as variations in electric resistivity, conduction of ultrasonic waves, or polarization of light in translucent objects." + }, + { + "input": "Concept: Tracheitis (Bacterial infections NEC)", + "output": "Tracheitis described as bacterial infectious process with formation of mucopurulent membranes affecting the trachea. Causative agents include Staphylococcus, Streptococcus, Haemophilus influenzae, Pseudomonas, and Klebsiella." + }, + { + "input": "Concept: Non-IDMC Trial Committee Documents Unspecified (Document type)", + "output": "Document type described as records pertaining to committees aside from the Independent Data Monitoring Committee." + }, + { + "input": "Concept: hair pulling (Behavioral tic)", + "output": "Obsessive-compulsive disorders and symptoms described as a disorder characterized by repetitive pulling out of one's hair resulting in noticeable hair loss; the individual experiences a rising subjective sense of tension before pulling out the hair and a sense of gratification or relief when pulling out the hair." + }, + { + "input": "Concept: Anterior division of left branch of atrioventricular bundle (Conducting system of subdivision of heart)", + "output": "something described as subdivision of conducting system of heart which enters the anterior papillary muscle of left ventricle and is continuous with the subendocardial branch of the anterior division of left branch of atrioventricular bundle." + }, + { + "input": "Concept: hyperlipoproteinemia (Disorder of plasma protein metabolism)", + "output": "Disorder of lipoprotein AND/OR lipid metabolism described as metabolic disease characterized by excess plasma lipoproteins, due to a disorder of lipoprotein metabolism; may be acquired or familial." + }, + { + "input": "Concept: CRSR01-Total Score (Finding)", + "output": "CRS-R Clinical Classification Question described as JFK Coma Recovery Scale-Revised (CRS-R) Total score." + }, + { + "input": "Concept: Atlantic killifish (Fundulus)", + "output": "Fish described as a resident intertidal species of fish that is mainly found in saltwater marshes and tidal creeks." + }, + { + "input": "Concept: Population genetics (Science of genetics)", + "output": "Science of genetics described as study of the distribution of genes in populations and of how genes and genotype frequencies are maintained or changed." + }, + { + "input": "Concept: NEPHELOMETRIC METHOD, LIPOPROTEINS (Medical Device)", + "output": "Medical Device described as a lipoprotein test system is a device intended to measure lipoprotein in serum and plasma. Lipoprotein measurements are used in the diagnosis and treatment of lipid disorders (such as diabetes mellitus), atherosclerosis, and various liver and renal diseases." + }, + { + "input": "Concept: Child-Pugh Class Unknown (Finding)", + "output": "Finding described as unable to determine the Child-Pugh class." + }, + { + "input": "Concept: First segment of sacrum (BONES OF VERTEBRAL COLUMN)", + "output": "Body Part, Organ, or Organ Component described as the first and largest of five sacral vertebrae, which ultimately fuse into one bone: the sacrum; superiorly, it articulates with the last lumbar vertebra." + }, + { + "input": "Concept: Test Article Physical Substance Classification (Class)", + "output": "Classification described as the physicochemical category that a test article belongs to based on the composition and properties of that article." + }, + { + "input": "Concept: Vertical incomitant strabismus (Disease or Syndrome)", + "output": "Disease or Syndrome described as a type of incomitant strabismus in which the angle of deviation varies as the patient's gaze shifts upwards and/or downwards." + }, + { + "input": "Concept: SIQR01-Change Bed Sheets (SIQR Questionnaire Question)", + "output": "SIQR Questionnaire Question described as symptom Impact Questionnaire - Change bed sheets." + }, + { + "input": "Concept: Trace Element Biochemistry (Biochemistry)", + "output": "something described as the branch of biochemistry concerned with the role of trace elements in metabolism." + }, + { + "input": "Concept: 9 cis-octadecenoic acid (FATTY ACIDS, LIPIDS AND LIPOPROTEINS)", + "output": "Product base described as monounsaturated fatty acid with 18 carbons and the double bond at the 9th carbon from the methyl end." + }, + { + "input": "Concept: universal (Property or Attribute)", + "output": "something described as present or occurring everywhere or in all things; applicable to all within a particular group." + }, + { + "input": "Concept: Immunoglobulin G4-Related Diseases (MULTISYSTEM DISORDER)", + "output": "Autoimmune disorders NEC described as a clinical disease characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration by IgG4-positive plasma cells." + }, + { + "input": "Concept: I worry about telling my (potential) spouse/partner that I may be unable to have children (Clinical or Research Assessment Question)", + "output": "something described as a question about whether an individual is worried about telling their current or potential spouse or partner that they may be unable to have children." + }, + { + "input": "Concept: dental granuloma (Disease or Syndrome)", + "output": "something described as a granuloma located at the root apex of a tooth." + }, + { + "input": "Concept: TRIAD3 (Ubiquitin-Transferase Gene)", + "output": "Gene or Genome described as this gene is involved in promoting the degradation of substrates by the proteasome." + }, + { + "input": "Concept: Subglottic Cancer pM0 TNM Finding (Subglottic Cancer Pathologic Distant Metastasis TNM Finding v6)", + "output": "Finding described as subglottic cancer with no distant metastasis." + }, + { + "input": "Concept: CA 15-3 (Indicator, Reagent, or Diagnostic Aid)", + "output": "Immunologic Factor described as mucin-1 (1255 aa, ~122 kDa) is encoded by the human MUC1 gene. This protein plays a role in both signaling and cell adhesion." + }, + { + "input": "Concept: mannoprotein breakdown (mannoprotein metabolic process)", + "output": "proteolysis involved in cellular protein catabolic process described as the chemical reactions and pathways resulting in the breakdown of mannoproteins, any protein that contains covalently bound mannose residues." + }, + { + "input": "Concept: Delta3 Gene Positive (Genetic finding)", + "output": "Laboratory or Test Result described as an indication that the DLL3 gene has been detected in a sample." + }, + { + "input": "Concept: Cryotherapy Systems, Tissue Ablation, Cardiac (Cryotherapy Systems, Tissue Ablation)", + "output": "something described as tissue ablation cryotherapy systems designed to ablate (i.e., produce a therapeutic lesion) regions of endocardial tissue that give rise to or support cardiac arrhythmia. These systems typically consist of a central computerized unit (i.e., a console) that provides the coolant (usually liquid nitrous oxide) from an integral tank; the console also includes electronic and mechanical components to perform and control the ablation during the catheterization procedure using dedicated software. Several detachable guiding and cryoablation catheters that may include balloon and single-point cryoablation catheters are also components of the system. Cardiac tissue ablation cryotherapy systems can be used under fluoroscopic guidance; they are mainly intended for patients suffering from drug refractory paroxysmal atrial fibrillation." + }, + { + "input": "Concept: Allergic sensitization (Disease or Syndrome)", + "output": "something described as a process characterized by a humoral or cell-mediated immune response to a foreign antigen resulting in the production of specific antibodies and/or immune cells which may then lead to an allergic disposition." + }, + { + "input": "Concept: negative regulation of transcription involved in G2/M transition of mitotic cell cycle (negative regulation of transcription, DNA-templated)", + "output": "Genetic Function described as any process that inhibits or decreases the frequency, rate or extent of transcription of target genes that are transcribed as part of the G2/M transition of the mitotic cell cycle." + }, + { + "input": "Concept: Chills & fever (Fever of Unknown Origin)", + "output": "something described as shivering secondary to a febrile process." + }, + { + "input": "Concept: If there was one thing that could have been done to improve your experience in this research study, what would it be (Intellectual Product)", + "output": "something described as a question about the one thing an individual would recommend to improve their experience participating in a research study." + }, + { + "input": "Concept: hyperplasia; erythroid (Disease or Syndrome)", + "output": "Polycythemia described as increased count of erythroid precursor cells, that is, erythroid lineage cells in the bone marrow." + }, + { + "input": "Concept: Product Type Code (Intellectual Product)", + "output": "something described as a coded value specifying the kind of product. EXAMPLE(S): veterinary medicine, diagnostic device. NOTE(S): All members of a type share similar functions and general characteristics, especially the purpose for which they are used." + }, + { + "input": "Concept: Compounds, Uranium (Inorganic Chemical)", + "output": "something described as inorganic compounds that contain uranium as an integral part of the molecule." + }, + { + "input": "Concept: DJ595C2.2 (Biologically Active Substance)", + "output": "Biologically Active Substance described as angiopoietin-related protein 1 (491 aa, ~57 kDa) is encoded by the human ANGPTL1 gene. This protein is involved in the regulation of hematopoietic stem cells." + }, + { + "input": "Concept: Neurology Electrodes (electrode)", + "output": "electrode described as electrodes designed to transmit or receive bioelectric signals from the nervous system and/or to apply electrical stimuli to the system. These electrodes are available in a variety of configurations including scalp electrodes (also known as skin or superficial electrodes), transcutaneous electrodes (e.g., transdermal needles), and implantable electrodes. Dedicated neurology electrodes are used for a variety of procedures, such as to detect and transmit bioelectric signals from the central nervous system, including the measurement recording, and/or monitoring of the brain function (i.e., electroencephalography), to deliver periodic electric stimuli to the brain (e.g., to alleviate tremors and/or seizures), to provide brain shock (i.e., electroconvulsive therapy), and to detect the brain and central nervous system response to several types of stimuli (i.e., evoked potential measurement). Electrodes capable of performing several of these tasks are also available." + }, + { + "input": "Concept: Grade 4 Diarrhea, CTCAE (Diarrhea, CTCAE)", + "output": "Diarrhea, CTCAE described as life-threatening consequences; urgent intervention indicated" + }, + { + "input": "Concept: anterior uveal melanoma (Neoplastic Process)", + "output": "Lesion of iris described as malignant tumor of melanocytes affecting the iris." + }, + { + "input": "Concept: Myeloid Cell Destruction Inhibition (Negative Regulation of Apoptosis)", + "output": "something described as any process that decreases the frequency, rate or extent of apoptosis in neutrophils, eosinophils or basophils." + }, + { + "input": "Concept: Abnormally shaped skeletal (Abnormality of the skeletal system)", + "output": "something described as an abnormality of the form, structure, or size of the skeletal system." + }, + { + "input": "Concept: human embryo (Embryonic Structures)", + "output": "Embryonic Structures described as early stage in the prenatal development of an animal. This stage occurs from implantation until closure of the hard palate." + }, + { + "input": "Concept: euphorbia peplus/petty spurg (Organic Chemical)", + "output": "Organic Chemical described as petty spurge." + }, + { + "input": "Concept: Aspirate;body fluids;cardiovas (Procedure categorized by device involved)", + "output": "Intervention regimes described as the puncture of a vein to draw blood for diagnostic analysis or to inject a solution." + }, + { + "input": "Concept: Infection associated neutropenia (Transient neutropenia)", + "output": "Finding described as transient neutropenia caused by an infection, such as with a virus, bacteria or protozoan." + }, + { + "input": "Concept: regulation of chorionic trophoblast cell proliferation (regulation of cell population proliferation)", + "output": "something described as any process that modulates the frequency, rate or extent of chorionic trophoblast cell proliferation." + }, + { + "input": "Concept: Sikhism (Religion)", + "output": "Religious Group described as a monotheistic religion founded in 16th century India, that combines elements of Hinduism and Islam." + }, + { + "input": "Concept: R360125 (Intellectual Product)", + "output": "Intellectual Product described as RAND 36-Item Health Survey 1.0 - How much of the time during the past 4 weeks: Have you felt so down in the dumps that nothing could cheer you up?" + }, + { + "input": "Concept: GARLIC (Vegetables)", + "output": "Dietary Supplements described as a bulbous herb isolated from the plant Allium sativum with potential antineoplastic activity. Garlic contains a number of different organosulfur compounds, some of which have displayed antineoplastic activity." + }, + { + "input": "Concept: PedsQL Neuromuscular Module Acute Version 3.0 Parent of Toddler - Hard for Family to Plan Activities (Intellectual Product)", + "output": "Intellectual Product described as pediatric Quality of Life Neuromuscular Module Acute Version 3.0 Parent of Toddler (PedsQL Neuromuscular Module Acute Version 3.0 Parent of Toddler) In the past 7 days, how much of a problem has this been for your child: It is hard for our family to plan activities like vacations." + }, + { + "input": "Concept: Sulcus rectus (Body Space or Junction)", + "output": "something described as a superficial feature of the frontal lobe identified by dissection. In the human it is a horizontal groove on the lower medial surface that separates the straight gyrus below from the inferior rostral gyrus above ( Mai-1997 ); in brains that have parallel sulci dorsal to the straight gyrus, it is called the inferior rostral sulcus ( Vogt-1995 ). In the macaque, which does not have an inferior rostral gyrus or a superior rostral gyrus, it separates the straight gyrus from the anterior cingulate gyrus ( Martin-2000 ). Equivalent structures are not found in the smooth cerebral cortex of the rat or mouse ( NeuroNames )." + }, + { + "input": "Concept: Feltys Syndrome (Felty Syndrome)", + "output": "Rheumatoid arthropathies described as a syndrome characterized by the presence of rheumatoid arthritis, splenomegaly, and granulocytopenia. Patients are at an increased risk of infection because of the low white cell counts." + }, + { + "input": "Concept: MOYAMOYA (Disease or Syndrome)", + "output": "Circulatory Diseases and Syndromes of Nervous System described as a noninflammatory, progressive occlusion of the intracranial CAROTID ARTERIES and the formation of netlike collateral arteries arising from the CIRCLE OF WILLIS. Cerebral angiogram shows the puff-of-smoke (moyamoya) collaterals at the base of the brain. It is characterized by endothelial HYPERPLASIA and FIBROSIS with thickening of arterial walls. This disease primarily affects children but can also occur in adults." + }, + { + "input": "Concept: Lower Extremity Pneumatic Exerciser (Manufactured Object)", + "output": "Exercisers, Muscle Strength, Pneumatic described as muscle strength exercisers designed to provide resistance to muscular contraction of the lower limbs using a pneumatic mechanism. These exercisers usually consist of a stand-alone machine with a pneumatic mechanism, a system to transmit the force (i.e., to convey the resistance), and lever bars on which the user exerts force to counteract the exerciser resistance. These exercisers are used to exercise the lower-limb (e.g., squat, lunge, leg press, leg extension, heel raise) muscles. Lower-limb pneumatic strength exercisers are intended to improve muscle strength in the lower limbs (e.g., buttock, thigh, calf, ankle); increase muscle size, endurance, and power; and improve bone density. Dedicated lower-limb strength exercisers are available for leg extension, leg press, and leg curl." + }, + { + "input": "Concept: Elevated Serum CA125 (Elevated Test Result)", + "output": "Elevated Test Result described as a finding indicating elevated concentrations of the tumor antigen CA-125 in a blood serum sample." + }, + { + "input": "Concept: exstrophy (Abnormality of the abdominal wall)", + "output": "Abnormality of the abdominal wall described as eversion of a hollow organ and exposure, inside out, and protruded through the abdominal wall." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Clinical Chemistry, Hepatic Function, Bilirubin, Direct (IVD Test Reagent/Kits, Clinical Chemistry, Hepatic Function)", + "output": "IVD Test Reagent/Kits, Clinical Chemistry, Hepatic Function described as clinical chemistry reagents intended to perform qualitative and/or quantitative chemical analysis of body fluids (typically in serum) to determine the level of direct (conjugated) bilirubin. Direct bilirubin is composed of both mono- and diconjugated bilirubin and the delta fraction tightly bound to albumin. The level of bilirubin in blood is commonly increased (i.e., hyperbilirubinemia) in several biliary-tree and hepatic disorders that usually produce jaundice." + }, + { + "input": "Concept: Protoplasts (Cells)", + "output": "Biospecimen described as a bacterial cell deprived of its cell wall, for example by growth in an isotonic medium in the presence of antibiotics that block synthesis of the wall peptidoglycan. Alternatively, a plant cell similarly deprived by enzymic treatment." + }, + { + "input": "Concept: FAC100-Limit: Walking Up 30 Stairs (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)", + "output": "Intellectual Product described as functional Assessment of Chronic Illness Therapy-Dyspnea Scale 33 Item Bank (FACIT-Dyspnea Scale 33 Item Bank Version) Functional Limitation: Considering your shortness of breath over the past 7 days, rate the amount of difficulty you had when doing the following activities: Walking up 30 stairs (3 flights) without stopping." + }, + { + "input": "Concept: Babesia divergens M'Fadyean & Stockman, 1911 (Babesia)", + "output": "Family Babesiidae described as a species of intraerythrocytic protozoan parasites in the family Babesiidae. B. divergens is transmitted by the tick Ixodes ricinus and it is the main causative agent of bovine babesiosis." + }, + { + "input": "Concept: up-regulation of immune system process (Physiologic Function)", + "output": "positive regulation of biological process described as any process that activates or increases the frequency, rate, or extent of an immune system process." + }, + { + "input": "Concept: TSSC4 Protein (Candidate Tumor Suppressor Protein)", + "output": "something described as protein TSSC4 (329 aa, ~34 kDa) is encoded by the human TSSC4 gene. This protein may be involved in the inhibition of both tumorigenesis and cell growth." + }, + { + "input": "Concept: appetite (Hunger)", + "output": "Feeding behaviors described as a desire to satisfy a physical or mental need, such as for food, sex, or adventure." + }, + { + "input": "Concept: QS-Peds-FACIT-F TESTCD (Intellectual Product)", + "output": "something described as test codes of questionnaire questions associated with the Pediatric Functional Assessment of Chronic Illness Therapy-Fatigue (Peds-FACIT-F) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: VIRGIN ISLANDS, BRITISH (Geographic Area)", + "output": "Country described as a British overseas territory, part of the British West Indies, lying about 60 miles east of Puerto Rico. Tortola is the main island, other islands include Virgin Gorda, Jost Van Dyke and Anegada." + }, + { + "input": "Concept: response to unfolded protein (Molecular Function)", + "output": "response to topologically incorrect protein described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." + }, + { + "input": "Concept: 7q21-q22.1 (Chromosome band)", + "output": "Chromosome band described as a chromosome band present on 7q" + }, + { + "input": "Concept: adenosine to inosine editing (Genetic Function)", + "output": "base conversion or substitution editing described as the conversion of an adenosine residue to inosine in an RNA molecule by deamination." + }, + { + "input": "Concept: Lymphatic System Therapeutic Procedure (Therapeutic or Preventive Procedure)", + "output": "Therapeutic or Preventive Procedure described as treatment targeted at the lymphatic system, often to reduce excess lymph fluid that can be caused by injury, cancer treatments, infection or a birth defect." + }, + { + "input": "Concept: Hydrogen Peroxide-hyaluronic Acid Intratumoral Injectable Formulation (Radiation-Sensitizing Agents)", + "output": "something described as a gel-based formulation composed of a very dilute solution of hydrogen peroxide (H2O2) combined with hyaluronic acid (HA), with potential radiosensitizing activity. Upon intratumoral injection and slow-release (SR) of H2O2 from the gel, H2O2 releases oxygen and inactivates anti-oxidative enzymes, thereby increasing the oxygen concentration in the tumor environment, which increases the efficacy of radiotherapeutic treatment. HA increases viscosity of the formulation and allows for the SR of H2O2; as compared to the injection of H2O2 alone, the addition of HA decreases diffusion of H2O2 to surrounding areas and enhances intratumoral H2O2 concentration over an increased period of time. Hypoxic tumors show a decreased response to radiotherapy; thus, increasing oxygen content increases tumor response to radiotherapy. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C129385\" active clinical trials using this agent." + }, + { + "input": "Concept: Model, Chemical (Study models)", + "output": "something described as representation of the structure, behavior or activity of a chemical or chemical processes or systems which can be manipulated to demonstrate the effects that various actions will have on the chemical or chemical process or system; do not confuse with STRUCTURAL MODEL." + }, + { + "input": "Concept: polkadots (Cell Component)", + "output": "Cell Component described as a punctate, filamentous structure composed of Bcl10 that appears in the cytoplasm of T-cells shortly after T-cell receptor stimulation. Polkadots stands for Punctate Oligomeric Killing and Activating DOmains Transducing Signals." + }, + { + "input": "Concept: Opioid Receptor Binding (G protein-coupled receptor binding)", + "output": "something described as a process that involves the non-covalent binding of opioids to one of four opioid receptors. These interactions are involved in mediation of analgesia, euphoria, and physical dependence to opioids." + }, + { + "input": "Concept: ERBB1 c.2582T>G (Cell or Molecular Dysfunction)", + "output": "Cell or Molecular Dysfunction described as a nucleotide substitution at position 2582 of the coding sequence of the EGFR gene where thymine has been mutated to guanine." + }, + { + "input": "Concept: NCR1 protein, human (Receptor)", + "output": "Receptor described as natural cytotoxicity triggering receptor 1 (304 aa, ~34 kDa) is encoded by the human NCR1 gene. This protein is involved in the positive regulation of natural killer cell-mediated cytotoxicity." + }, + { + "input": "Concept: PODCI Adolescent Parent-Reported Version - Games Limited by: Instructions (Intellectual Product)", + "output": "something described as pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported - If you answered \"no\" to Question 44 above, was your child's activity limited by: Doctor or parent instructions?" + }, + { + "input": "Concept: Giving patient an enema, NOS (Injection procedure)", + "output": "Elimination Management described as the insertion or injection of a substance through the anus, usually for the purpose of stimulating evacuation of the bowels." + }, + { + "input": "Concept: 99mTc Ethylenedicysteine-Deoxyglucose (Indicator, Reagent, or Diagnostic Aid)", + "output": "Radioconjugate described as a radiopharmaceutical consisting of ethylenedicysteine-deoxyglucose (EC-DG) labeled with the metastable radioisotope technetium Tc-99 (99mTc). Upon administration, technetium Tc 99m ethylenedicysteine-deoxyglucose accumulates in cells with increased metabolic activity such as proliferating tumor cells; tumor tissue may then be imaged using gamma scintigraphy. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C82377\" active clinical trials using this agent." + }, + { + "input": "Concept: upregulation of interleukin-13 production (regulation of interleukin-13 production)", + "output": "Organism Function described as any process that activates or increases the frequency, rate, or extent of interleukin-13 production." + }, + { + "input": "Concept: Leifsonia species (Microbacteriaceae)", + "output": "Microbacteriaceae described as a genus of Gram positive, coryneform bacterium assigned to the phylum Actinobacteria and the family Microbacteriaceae." + }, + { + "input": "Concept: adenovirus, NOS (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as vaccines used to prevent infection by any virus from the family ADENOVIRIDAE." + }, + { + "input": "Concept: Other Clinical Trial (Research Activity)", + "output": "Clinical Trials described as a clinical trial that is not therapeutic, preventive or diagnostic." + }, + { + "input": "Concept: Simulators, Bone Sound Conduction, Mastoid (Simulators)", + "output": "something described as simulators designed to mimic the sound conduction characteristics of the human mastoid bone that are mainly intended to assess and calibrate bone-conducting hearing aids. These simulators usually consist of a tabletop electromechanical device that resembles a human head and a force transducer to evaluate the output level and frequency response of the device under assessment following a given standard (e.g., ANSI, IEC). The simulator is mounted on springs to provide isolation from the table. Mastoid simulators are also used to assess the characteristics of audiometer bone vibrators." + }, + { + "input": "Concept: Disease Steps Clinical Classification Test Code (CDISC Clinical Classification Terminology)", + "output": "Intellectual Product described as disease Steps test code." + }, + { + "input": "Concept: Thioamides (Drug allergen by structure)", + "output": "something described as organic compounds containing the radical -CSNH2." + }, + { + "input": "Concept: Gastric Cancer pN3a TNM Finding v8 (Gastric Cancer pN3 TNM Finding v8)", + "output": "Finding described as gastric cancer with metastasis in seven to fifteen regional lymph nodes." + }, + { + "input": "Concept: TIC protocol (Therapeutic or Preventive Procedure)", + "output": "something described as a regimen consisting of paclitaxel, ifosfamide, mesna and carboplatin used as salvage therapy for the treatment of advanced-stage testicular cancer; also used for the treatment of unresectable and recurrent squamous cell head and neck cancer." + }, + { + "input": "Concept: Summary (Mean) T Wave Area (ECG Measurement)", + "output": "ECG Measurement described as the average (mean) \"area under the curve\" of the deflection from baseline of the T wave (representing ventricular repolarization), obtained from a set of measurements of the T wave, from a single lead or set of leads." + }, + { + "input": "Concept: Cytopathogenic Effect, Viral (Virus Physiological Phenomena)", + "output": "Virus Physiological Phenomena described as visible morphologic changes in cells infected with viruses. It includes shutdown of cellular RNA and protein synthesis, cell fusion, release of lysosomal enzymes, changes in cell membrane permeability, diffuse changes in intracellular structures, presence of viral inclusion bodies, and chromosomal aberrations. It excludes malignant transformation, which is CELL TRANSFORMATION, VIRAL. Viral cytopathogenic effects provide a valuable method for identifying and classifying the infecting viruses." + }, + { + "input": "Concept: Unspecified papilloedema (Inflammation)", + "output": "Cranial nerve diseases described as papilledema refers to edema (swelling) of the optic disc secondary to any factor which increases cerebral spinal fluid pressure." + }, + { + "input": "Concept: Grade 3 Ileal Hemorrhage, CTCAE (Ileal Hemorrhage, CTCAE)", + "output": "something described as transfusion indicated; invasive intervention indicated; hospitalization" + }, + { + "input": "Concept: ascaroside metabolism (Molecular Function)", + "output": "something described as the chemical reactions and pathways involving ascaroside." + }, + { + "input": "Concept: CDISC Clinical Classification TIMI Thrombus Grade Test Name Terminology (Intellectual Product)", + "output": "CDISC Clinical Classification Terminology described as coronary Thrombus TIMI Grade test name." + }, + { + "input": "Concept: h.pg/ml/(mg/kg) (Quantitative Concept)", + "output": "Quantitative Concept described as a dose calculation unit expressed in hours times picograms per milliliter, divided by milligram per kilogram." + }, + { + "input": "Concept: Unknown Tumor Infiltrating Lymphocytes (Finding)", + "output": "Finding described as a finding of an unknown number of tumor infiltrating lymphocytes in a biospecimen." + }, + { + "input": "Concept: Occasional Urinary Incontinence (Finding)", + "output": "something described as a response indicating that an individual has an occasional accident related to urinary incontinence." + }, + { + "input": "Concept: cinereum tuber (Hypothalamus, Middle)", + "output": "something described as a convex mass of grey matter located between the mammillary bodies and the optic chiasma on the inferior surface of the hypothalamus, and from which the infundibulum extends to the posterior lobe of the hypophysis." + }, + { + "input": "Concept: WNT7A protein, human (Amino Acid, Peptide, or Protein)", + "output": "something described as protein Wnt-7a (349 aa, ~39 kDa) is encoded by the human WNT7A gene. This protein plays a role in intercellular communication and the regulation of cell fate and patterning during embryogenesis." + }, + { + "input": "Concept: O-glycoside breakdown (glycoside metabolic process)", + "output": "glycosyl compound catabolic process described as the chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." + }, + { + "input": "Concept: N'-[4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitrosourea (Pharmacologic Substance)", + "output": "Nitrosourea Compounds described as a nitrosourea with antineoplastic activity. Nimustine alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C693\" active clinical trials using this agent." + }, + { + "input": "Concept: pre miRNA (Nucleic Acid, Nucleoside, or Nucleotide)", + "output": "Nucleic Acid, Nucleoside, or Nucleotide described as the pre-miRNA is an oligoribonucleotide intermediate of nuclear transcription that is further processed cytosolically by the Dicer enzyme to form 20-25 nt mature miRNA products. Such RNA intermediates, typically 65-110 nt in length, form stem-loop structures that play an important role in the processing of these oligonucleotides to the mature miRNA form." + }, + { + "input": "Concept: viral protein anabolism (viral process)", + "output": "something described as a process by which viral mRNA is translated into viral protein, using the host cellular machinery." + }, + { + "input": "Concept: therapeutic triiodothyronine (Thyroid preparations)", + "output": "Serology described as a therapeutic formulation of the primary physiologically active form of endogenous thyroid hormone. In vivo, triiodothyronine enters the nucleus and binds to nuclear thyroid hormone receptors that subsequently bind to thyroid response elements (TREs) located in target genes. Receptor binding by triiodothyronine in combination with recruited coactivators results in maximal transcriptional activation after binding to TREs; in general, binding of thyroid hormone receptor alone to TREs leads to repression of gene transcription" + }, + { + "input": "Concept: Polymyxin B2 (Antibiotic)", + "output": "Polymyxin Antibiotic described as a polypeptide obtained from Bacillus polymyxa strains with antimicrobial activity. Polymyxin B2 exerts its antimicrobial effect through its cationic detergent action on cell membranes. Specifically, this antibiotic binds to the negatively charged site in the lipopolysaccharide layer of the bacterial cell membrane via electrostatic affinity with the positively charged amino groups in the cyclic peptide portion. Subsequently, the fatty acid portion of polymyxin B2 dissolves in the hydrophobic region of the bacterial cell membrane. This results in an alteration in cell membrane structure, disruption of cell wall integrity and an increase in permeability for water and molecules. This will eventually lead to bacterial cell death." + }, + { + "input": "Concept: c-erbB1 Gene Amplification Negative (Negative Test Result)", + "output": "Genetic finding described as an indication that amplification of the EGFR gene was not detected in a sample." + }, + { + "input": "Concept: retromer CSC (membrane protein complex)", + "output": "membrane protein complex described as the trimeric subcomplex of the retromer, believed to be closely associated with the membrane. This trimeric complex is responsible for recognizing and binding to cargo molecules. The complex comprises three Vps proteins in both yeast and mammalian cells: Vps35p, Vps29p, and Vps26p in yeast, and VPS35, VPS29 and VPS26A or VPS26B in mammals." + }, + { + "input": "Concept: Anatomical zone (General anatomical term)", + "output": "General anatomical term described as general anatomical term that is an arbitrary subdivision of an anatomical structure." + }, + { + "input": "Concept: Histiocytoma, Angiomatoid Fibrous (Neoplasm, uncertain whether benign or malignant)", + "output": "Neoplastic Process described as a low malignant potential soft tissue neoplasm of uncertain differentiation. It typically affects young patients, presenting as a slowly growing nodular or cystic tumor mass, most often in the subcutaneous tissues of the extremities. Occasionally, patients have systemic symptoms (anemia, fever, and weight loss). This tumor has a relatively good prognosis. A minority of patients develop local recurrences. Metastases are rare." + }, + { + "input": "Concept: Severity Score 2 (Clinical or Research Assessment Answer)", + "output": "Clinical or Research Assessment Answer described as a subjective score of 2 on a severity scale that ranges from 0: Not at all severe to 10: most severe." + }, + { + "input": "Concept: Childhood Thyroid Gland Medullary Carcinoma (Neoplastic Process)", + "output": "something described as a medullary thyroid gland carcinoma occurring in childhood." + }, + { + "input": "Concept: cluster assembly (iron-sulfur cluster assembly)", + "output": "iron-sulfur cluster assembly described as the incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster." + }, + { + "input": "Concept: Bosnia-Hercegovina (Europe, Eastern)", + "output": "something described as a country in southeastern Europe, bordering the Adriatic Sea, between Croatia and Serbia." + }, + { + "input": "Concept: Elevated HGFR Protein Expression (Finding)", + "output": "something described as an indication that elevated concentrations of MET protein were found in a sample." + }, + { + "input": "Concept: ENA +, highest ever titer 1: (ENA: extractable nuclear antigen antibody)", + "output": "something described as ENA (Extractable Nuclear Antigen): a complex antigen mixture extracted from calf thymus nuclei by isotonic buffer, containing primarily ribonucleoprotein (RNP) and Sm antigen." + }, + { + "input": "Concept: laricitrin 5'-O-methyltransferase activity (O-methyltransferase activity)", + "output": "S-adenosylmethionine-dependent methyltransferase activity described as catalysis of the reaction: S-adenosyl-L-methionine + laricitrin = S-adenosyl-L-homocysteine + syringetin." + }, + { + "input": "Concept: trans-1-(2-pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene (COUGH AND COLD PREPARATIONS)", + "output": "Pharmacologic Substance described as histamine H1 antagonist used in allergic rhinitis; ASTHMA; and URTICARIA. It is a component of COUGH and COLD medicines. It may cause drowsiness." + }, + { + "input": "Concept: primary cell wall (Cell Component)", + "output": "plant-type cell wall described as a plant cell wall that is still able to expand, permitting cell growth. Primary cell walls contain more pectin than secondary walls and no lignin is present." + }, + { + "input": "Concept: glucosylceramide metabolism (glycosylceramide metabolic process)", + "output": "Molecular Function described as the chemical reactions and pathways involving glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. They are neutral glycolipids containing equimolar amounts of fatty acid, glucose, and sphingosine or a sphingosine derivative." + }, + { + "input": "Concept: Grade 1 Psychiatric disorders - Other, specify (Finding)", + "output": "something described as asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated" + }, + { + "input": "Concept: PYRROLNITRIN (Pharmacologic Substance)", + "output": "Organic Chemical described as 3-Chloro-4-(3-chloro-2-nitrophenyl)pyrrole. Antifungal antibiotic isolated from Pseudomonas pyrrocinia. It is effective mainly against Trichophyton, Microsporium, Epidermophyton, and Penicillium." + }, + { + "input": "Concept: Patellofemoral Joint (Component of knee joint)", + "output": "Synovial joint of free lower limb segment described as the articulation between the articular surface of the PATELLA and the patellar surface of the FEMUR." + }, + { + "input": "Concept: CD164 Antigen (CD Antigens)", + "output": "Sialomucins described as a sialomucin protein that functions as a cell adhesion molecule. It is a negative regulator of certain types of HEMATOPOIETIC STEM CELLS." + }, + { + "input": "Concept: ENVIR PROTECTION AGENCY UNITED STATES (Professional Organization or Group)", + "output": "Professional Organization or Group described as the EPA is the US Government's watchdog agency responsible for controlling the pollution of air and water, pesticides, radiation hazards and noise pollution. The agency is also involved in research to examine the effects of pollution." + }, + { + "input": "Concept: Guantanamo Bay Naval Base (Geographic Area)", + "output": "Country described as a US Navy military base located on Guantanamo Bay in Cuba." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, BBS2 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)", + "output": "Medical Device described as molecular assay reagents intended to identify mutations in the Bardet-Biedl syndrome 2 (BBS2) gene, located at chromosome 16q21, which encodes the Bardet-Biedl syndrome 2 protein. Genetic variants at this locus have been associated with retinitis pigmentosa 74 and Bardet-Biedl syndrome 2." + }, + { + "input": "Concept: Nanostructures (Nanoparticle Complex)", + "output": "Manufactured Object described as a bulk material composed of discrete nano-substructures that are engineered, synthesized and characterized for a myriad of applications." + }, + { + "input": "Concept: Galactosephosphates (Organic Chemical)", + "output": "something described as phosphoric acid esters of galactose." + }, + { + "input": "Concept: Foetal hypoxia (Hypoxia, asphyxia AND/OR other respiratory condition of fetus AND/OR newborn)", + "output": "Perinatal hypoxia described as hypoxia in utero, caused by conditions such as inadequate placental function (often abruptio placentae), preeclamptic toxicity, prolapse of the umbilical cord, or complications from anesthetic administration." + }, + { + "input": "Concept: Lymphoproliferative disorder caused by methotrexate (Drug-induced immunodeficiency)", + "output": "Other Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders described as rare immunodeficiency-associated lymphoproliferative disease with characteristics of lymphoid proliferation or lymphomas (large B-cell lymphoma, T-cell lymphoma, Hodgkin lymphoma, reactive lymphadenitis and a polymorphic post-transplant lymphoproliferative disorder) that develop in patients with different autoimmune diseases treated with methotrexate. Swelling is the predominant manifestation of the disease and regression after methotrexate withdrawal is observed in a significant proportion of patients." + }, + { + "input": "Concept: Scanning Systems, Laser, Optical Coherence Tomography, Ophthalmic (Scanning Systems, Laser, Optical Coherence Tomography)", + "output": "Scanning Systems, Laser, Optical Coherence Tomography described as optical coherence tomography (OCT) scanning systems designed to obtain cross-sectional images of eye (i.e., ophthalmic) tissues. These systems typically consist of a computerized unit that includes a light source, a photodetector, and a display. The light beam (usually in the infrared range) is divided into two beams, one directed towards the sample and the other towards a moving reference mirror. Tomographic images are then obtained by detecting the interference between the light reflected by both beams. The images obtained can show tissue about two or three mm (0.08 to 0.12 inch) in depth and provide axial and lateral resolution in the order of micrometers. The systems reveal the underlying structure not directly observable (tomographic images) in an analogous way, but with higher image resolution than conventional B-mode ultrasound and magnetic resonance imaging. Systems that use light sources at different frequencies simultaneously (spectral domain systems), rather than a mechanical movement of a mirror, are also available. OCT ophthalmic scanning systems are used for a variety of clinical applications involving accurate retinal and intraretinal thickness measurements." + }, + { + "input": "Concept: Cystic Fibrosis Carrier Screening (Diagnostic Procedure)", + "output": "something described as a genetic test to determine if either parent has the trait of cystic fibrosis carrier." + }, + { + "input": "Concept: Very-Low-Birth-Weight Infants (Disease or Syndrome)", + "output": "Low Birth Weight Infant described as an infant whose weight at birth is less than 1500 grams (3.3 lbs), regardless of gestational age." + }, + { + "input": "Concept: santoninum/santonin (Organic Chemical)", + "output": "Organic Chemical described as santonin." + }, + { + "input": "Concept: NCCN-FACT-FPSI 17 Version 2 - Bothered by Treatment Side Effect (Intellectual Product)", + "output": "something described as national Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Prostate Symptom Index 17 Version 2 (NCCN-FACT-FPSI 17 Version 2) I am bothered by side effects of treatment." + }, + { + "input": "Concept: Cancer of Uterine Cervix (Malignant tumor of cervix)", + "output": "Neoplasms described as cancer that forms in tissues of the cervix (the organ connecting the uterus and vagina). It is usually a slow-growing cancer that may not have symptoms but can be found with regular Pap tests (a procedure in which cells are scraped from the cervix and looked at under a microscope). Cervical cancer is almost always caused by human papillomavirus (HPV) infection." + }, + { + "input": "Concept: Malpighian tubule stellate cell differentiation (epithelial cell differentiation)", + "output": "something described as the process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule stellate cell. A Malpighian tubule stellate cell is a specialized epithelial secretory cell that moves chloride ions and water across the tubule epithelium." + }, + { + "input": "Concept: Heterogeneous Nuclear Ribonucleoprotein A2/B1 (RNA-Binding Proteins)", + "output": "something described as heterogeneous nuclear ribonucleoproteins A2/B (353 aa, ~37 kDa) is encoded by the human HNRNPA2B1 gene. This protein is involved in both RNA splicing and transport." + }, + { + "input": "Concept: Image Display Error / Artifact (Finding)", + "output": "Display or Visual Feedback Problem described as problem with image display leading to corrupted images or readouts/measurement indications." + }, + { + "input": "Concept: EPIC-CP - Sexual Symptom Score (EPIC-CP Questionnaire Question)", + "output": "something described as expanded Prostate Cancer Index Composite for Clinical Practice (EPIC-CP) Sexual symptom score." + }, + { + "input": "Concept: Twenty Four (Quantitative Concept)", + "output": "Numbers described as a natural number greater than twenty-three and less than twenty-five and the quantity that it denotes." + }, + { + "input": "Concept: ergotamine tartrate (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as the tartrate salt form of ergotamine, an ergot alkaloid and adrenergic alpha agonist with vasoconstrictor activity. Ergotamine tartrate selectively binds to alpha-adrenergic receptors thereby stimulating vascular smooth muscle and causing vasoconstriction in both arteries and veins. Ergotamine tartrate also blocks serotonin 5-HT1D receptors, thereby also causing vasoconstriction in cerebral blood vessels. Constriction of cerebral blood vessels caused by this agent may reduce the blood flow and pressure in cerebral arteries and may relieve the pain of vascular headaches." + }, + { + "input": "Concept: Biliary cyst (Bile Duct Diseases)", + "output": "Other diseases of biliary tract described as a cystic dilatation that occurs in any part of the biliary tree." + }, + { + "input": "Concept: COXEN Score 12 (Finding)", + "output": "COXEN Sensitivity Scale described as a score of 12 on the COXEN Sensitivity Scale." + }, + { + "input": "Concept: SHMT (SHMT1 gene)", + "output": "something described as human SHMT1 wild-type allele is located in the vicinity of 17p11.2 and is approximately 36 kb in length. This allele, which encodes serine hydroxymethyltransferase, cytosolic protein, plays a role in the metabolism of both amino acids and folate." + }, + { + "input": "Concept: CSS03-Most Recent Attempt Potential (C-SSRS Baseline/Screening Version Phase 1 Study Version 1/14/09 Questionnaire Question)", + "output": "Intellectual Product described as columbia-Suicide Severity Rating Scale Baseline/Screening Version Phase 1 Study - Most recent attempt potential lethality." + }, + { + "input": "Concept: Reflex Observable (Psychophysiology)", + "output": "Neurological observable described as simple automatic involuntary neuromuscular responses to stimuli." + }, + { + "input": "Concept: Homologous-Pairing Protein 2 Homolog (Amino Acid, Peptide, or Protein)", + "output": "something described as homologous-pairing protein 2 homolog (217 aa, ~25 kDa) is encoded by the human PSMC3IP gene. This protein is involved in the pairing of homologous chromosomes during meiosis and coactivation of hormone-dependent transcription." + }, + { + "input": "Concept: EVACUATOR, ORAL CAVITY (Medical Device)", + "output": "something described as a dental operative unit and accessories is an AC-powered device that is intended to supply power to and serve as a base for other dental devices, such as a dental handpiece, a dental operating light, an air or water syringe unit, and oral cavity evacuator, a suction operative unit, and other dental devices and accessories. The device may be attached to a dental chair." + }, + { + "input": "Concept: Short third metatarsal (Anatomical Abnormality)", + "output": "Anatomical Abnormality described as underdevelopment of the Third metatarsal bone leading to a short (hypoplastic) third metatarsal bone." + }, + { + "input": "Concept: negative regulation of mesenchymal cell proliferation (regulation of mesenchymal cell proliferation)", + "output": "something described as any process that decreases the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." + }, + { + "input": "Concept: Experimental Organism Intramural Schwannoma (Experimental Organism Neoplasm)", + "output": "Experimental Organism Neoplasm described as a malignant schwannoma of the heart of the heart arising from intramural swan cells that appears as a poorly circumscribed spindle cell mass within the ventricular myocardium with a more discrete boundary, that is generally more infiltrative than expansile." + }, + { + "input": "Concept: integral component of mitochondrial inner membrane (integral component of mitochondrial membrane)", + "output": "Cell Component described as the component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." + }, + { + "input": "Concept: salicylate 1-hydroxylase activity (Molecular Function)", + "output": "something described as catalysis of the reaction: salicylate + NADH + H+ + O2 = catechol + NAD+ + H2O + CO2." + }, + { + "input": "Concept: Shea Butter Extract (S [Preparations])", + "output": "Plant Oils described as an oil obtained from the seed of Butyrospermum parkii. Sheanut oil is used as an ingredient in skincare products." + }, + { + "input": "Concept: FMS-Related Tyrosine Kinase 3 c.2517T>A (Cell or Molecular Dysfunction)", + "output": "something described as a nucleotide substitution at position 2517 of the coding sequence of the FLT3 gene where thymine has been mutated to adenine." + }, + { + "input": "Concept: Viral Coat Protein (Viral Proteins)", + "output": "Viral Proteins described as the outer protective shell of a virus. The structure of the shell is icosahedral with either helical or complex symmetry. Capsid proteins surround and protect the viral nucleic acid core." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Immunoassay, Pregnancy Hormone (Medical Device)", + "output": "Medical Device described as immunoassay reagents intended to perform qualitative and/or quantitative analyses of a sample or body fluids (typically serum) to determine one or more of the group of hormones (either steroid or protein hormones) that are related to the detection, evaluation, and monitoring of human pregnancy; the hormones related to pregnancy are mostly secreted by the ovaries and adrenal glands, usually under control from the hypothalamus and pituitary glands." + }, + { + "input": "Concept: Insert (Biomedical or Dental Material)", + "output": "something described as a solid, sterile single-dose form suitable for insertion into a body cavity that may be provided with an administration device. Inserts are intended for release over an extended period of time." + }, + { + "input": "Concept: sodium butyrate (Organic Chemical)", + "output": "Pharmacologic Substance described as the sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). This binding affects hyperacetylation of histones, resulting in a modified DNA conformation, which subsequently leads to the uncoiling or relaxing of chromatin. Enhanced accessibility of chromatin to transcription-regulatory complexes leads to increased transcriptional activation of various epigenetically suppressed genes. Butyrate, a HDAC inhibitor, induces cell cycle arrest in G1 or G2/M and also increases the expression of other genes and proteins involved in cellular differentiation and apoptotic signaling." + }, + { + "input": "Concept: Epithelial dysplasia, NOS (Intraepithelial Neoplasia)", + "output": "Precancerous Conditions described as a precancerous neoplastic process that affects the squamous, glandular, or transitional cell epithelium without evidence of invasion. According to the degree of nuclear atypia, number of mitotic figures, and presence of architectural distortion, it is classified as low grade (mild dysplasia) or high grade (moderate or severe dysplasia)." + }, + { + "input": "Concept: Control Point (Parameter Value)", + "output": "Parameter Value described as any one of a set of linear accelerator parameters that define the segments from which a radiation beam is applied." + }, + { + "input": "Concept: Lungs--Diseases, Obstructive (Bronchospasm and obstruction)", + "output": "Abnormal breathing described as any disorder marked by obstruction of conducting airways of the lung. AIRWAY OBSTRUCTION may be acute, chronic, intermittent, or persistent." + }, + { + "input": "Concept: Bleomycin/Cytarabine/Prednisone/Vincristine Regimen (Regimen Used to Treat Non-Hodgkin Lymphoma)", + "output": "Regimen Used to Treat Non-Hodgkin Lymphoma described as a regimen consisting of bleomycin, cytarabine, prednisone and vincristine that can be used for the treatment of malignant lymphoma." + }, + { + "input": "Concept: M-Type Receptor (receptor)", + "output": "Receptor described as secretory phospholipase A2 receptor (1463 aa, ~169 kDa) is encoded by the human PLA2R1 gene. This protein plays a role in the modulation of phospholipase activity." + }, + { + "input": "Concept: High Intensity Light or Pulse Light (Sterilization for infection control)", + "output": "something described as a sterilization process that uses intense and short duration pulses of wavelengths of light from the ultraviolet to the near infrared regions to kill microorganisms." + }, + { + "input": "Concept: spermatid cell development (Gametogenesis)", + "output": "MALE REPRODUCTIVE FUNCTIONS AND SYMPTOMS described as the process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." + }, + { + "input": "Concept: Hemi Arthroplasty (Arthroplasty, Replacement)", + "output": "something described as a partial joint replacement in which only one surface of the joint is replaced with a PROSTHESIS." + }, + { + "input": "Concept: lost (Functional Concept)", + "output": "General Qualifier described as parted with; no longer held or possessed; incapable of being recovered or regained." + }, + { + "input": "Concept: Specimen.typeCode (Intellectual Product)", + "output": "something described as a coded value specifying the kind of specimen." + }, + { + "input": "Concept: Community Networks (Information Systems)", + "output": "something described as organizations and individuals cooperating together toward a common goal at the local or grassroots level." + }, + { + "input": "Concept: reminyl (Organic Chemical)", + "output": "Organic Chemical described as name of the FDA approved preparation from J&J." + }, + { + "input": "Concept: coagulation factor VIII (Amino Acid, Peptide, or Protein)", + "output": "Biologically Active Substance described as antihemophilic factor that is part of the factor VIII/von Willebrand factor complex; produced in the liver and acts in the intrinsic pathway of blood coagulation; serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin." + }, + { + "input": "Concept: Densovirus of Aedes (Densovirus)", + "output": "Brevidensovirus described as type species of Brevidensovirus." + }, + { + "input": "Concept: tropane alkaloid metabolic process (Molecular Function)", + "output": "something described as the chemical reactions and pathways involving tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ring system." + }, + { + "input": "Concept: regulation of ergosterol biosynthetic process (regulation of sterol biosynthetic process)", + "output": "Molecular Function described as any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol." + }, + { + "input": "Concept: Pseudobacterium ventriosum (Eubacterium)", + "output": "something described as any bacterial organism that can be assigned to the species Eubacterium ventriosum." + }, + { + "input": "Concept: Urea-Positive Providencia stuartii (Providencia stuartii)", + "output": "Providencia stuartii described as any bacterial organism that can be assigned to the species Providencia stuartii and is able to metabolize urea." + }, + { + "input": "Concept: prostatic intraepithelial neoplasia (Carcinoma in situ of urinary tract)", + "output": "Dysplasia of prostate described as a neoplastic proliferation of the epithelial cells that line the acini and the ducts of the prostate gland. The neoplastic epithelial cells are confined within the acini and the ducts and they do not invade the surrounding prostatic stroma. Morphologically, it is classified as low or high grade. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C4064\" active clinical trials using this agent." + }, + { + "input": "Concept: Mesenteric Ischemias (Peritoneal Diseases)", + "output": "Disorder of soft tissue of trunk described as chemic tissue injury produced by insufficient perfusion of intestinal tissue by the MESENTERIC CIRCULATION (i.e., CELIAC ARTERY; SUPERIOR MESENTERIC ARTERY; INFERERIOR MESENTERIC ARTERY; and MESENTERIC VEINS). It can progress from ISCHEMIA; EDEMA; and GANGRENE of the bowel wall to PERITONITIS and cardiovascular collapse." + }, + { + "input": "Concept: alpha3-beta1 integrin complex location (integrin complex)", + "output": "integrin complex described as an integrin complex that comprises one alpha3 subunit and one beta1 subunit." + }, + { + "input": "Concept: Benign Neoplasm of Scrotum (Neoplastic disease)", + "output": "Benign neoplasm of male genital organ described as a non-metastasizing neoplasm that arises from the scrotum." + }, + { + "input": "Concept: 19: 52874031-52898291 (Chromosome 19 Physical Location)", + "output": "something described as physical location of GLTSCR1_Gene" + }, + { + "input": "Concept: PedsQL Neuromuscular Module Version 3.0 Young Adult Report - Hard to Breathe (Intellectual Product)", + "output": "PedsQL Neuromuscular Module Version 3.0 Young Adult Report Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Version 3 Young Adult - In the past one month, how much of a problem has this been for you: It is hard to breathe." + }, + { + "input": "Concept: Lateral segment of corticospinal tract of spinal cord (Spinal cord, roots and ganglia structure)", + "output": "something described as an oval shaped area within the corticospinal tract that runs the entire length of the spinal cord just medial to the posterior spinocerebellar tract and contains motor nerve fibers originating from the opposite cerebral hemisphere." + }, + { + "input": "Concept: Environmental Health Science (Health Occupations)", + "output": "Health Occupations described as the science of controlling or modifying those conditions, influences, or forces surrounding man which relate to promoting, establishing, and maintaining health." + }, + { + "input": "Concept: Esophagogastric Junction (Junction of stomach)", + "output": "Gastrointestinal system described as the place where the esophagus is connected to the stomach." + }, + { + "input": "Concept: Duligotuzumab (Pharmacologic Substance)", + "output": "Immunologic Factor described as an immunoglobulin (Ig) G1 monoclonal antibody directed against both human epidermal growth factor receptor 3 (HER3 or ERBB3) and human epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Duligotuzumab binds to both EGFR and HER3 and inhibits their activation. This may prevent EGFR/HER3-mediated signaling and inhibit EGFR/HER3-dependent tumor cell proliferation. In addition, MEHD7945A induces antibody-dependent cell-mediated cytotoxicity (ADCC) against EGR/HER3-expressing tumor cells. EGFR and HER3, members of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, are frequently overexpressed in tumors; their expression is associated with both poor prognosis and drug resistance." + }, + { + "input": "Concept: Chronic kidney disease following donor nephrectomy (Disease or Syndrome)", + "output": "something described as chronic kidney disease developing de novo in a person who has previously donated a kidney for the purposes of kidney transplanataion." + }, + { + "input": "Concept: DENN Domain-Containing Protein 3 (Guanine Nucleotide Exchange Factors)", + "output": "Amino Acid, Peptide, or Protein described as DENN domain-containing protein 3 (1198 aa, ~136 kDa) is encoded by the human DENND3 gene. This protein is involved in the activation of Ras-related protein Rab-12 through guanine nucleotide exchange." + }, + { + "input": "Concept: Brodmann's area 23 (Brodmann area)", + "output": "Brodmann area described as a subdivision of the cytoarchitecturally defined cingulate region of cerebral cortex. In the human it occupies most of the posterior cingulate gyrus adjacent to the corpus callosum. At the caudal extreme it is bounded approximately by the parieto-occipital sulcus. Cytoarchitecturally it is bounded dorsally by the area 31 of Brodmann (human), rostrally by the area 24 of Brodmann (human), and ventrorostrally in its caudal half by the retrosplenial area ( Brodmann-1909 )." + }, + { + "input": "Concept: vomitoxin formation (mycotoxin biosynthetic process)", + "output": "something described as the chemical reactions and pathways resulting in the formation of type B trichothecene vomitoxin, a poisonous substance produced by some species of fungi and predominantly occurs in grains such as wheat, barley and oats." + }, + { + "input": "Concept: Filtration Process, Inadequate (Finding)", + "output": "something described as problem associated with the filter failing to remove items or substances which should have been removed." + }, + { + "input": "Concept: Metastatic Lobular Breast Carcinoma (Breast adenocarcinoma metastatic)", + "output": "something described as a lobular breast carcinoma which has spread from the original site of growth to another anatomic site." + }, + { + "input": "Concept: Nanomedicines, Theranostic (Medicine)", + "output": "Medicine described as an integrated nano-scale approach to MEDICINE which involves concurrent diagnosis, drug delivery, therapy, and monitoring of therapeutic response." + }, + { + "input": "Concept: Assisted suicide (Suicide)", + "output": "Death and sudden death described as provision (by a physician or other health professional, or by a family member or friend) of support and/or means that gives a patient the power to terminate his or her own life. (from APA, Thesaurus of Psychological Index Terms, 8th ed)." + }, + { + "input": "Concept: spinal cord radial glial cell differentiation (Cell Function)", + "output": "radial glial cell differentiation described as the process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of radial glial cells. Radial cell precursors differentiate into both neuronal cell types and mature radial glial cells. Mature radial glial cells regulate the axon growth and pathfinding processes that occur during white matter patterning of the developing spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." + }, + { + "input": "Concept: 2-Cyanaziridinyl-2-carbamoyl-aziridinyl-1-propane (Pharmacologic Substance)", + "output": "Radiation-Protective Agents described as azimexon (2-cyanaziridinyl-2-carbamoyl-aziridinyl-1-propane) is a derivative of 2-cyanaziridine. Immunostimulant which shows therapeutic effects in tumor models and experimental infections in vitro, enhancing T lymphocyte transformation and phagocytosis. The mode of action of azimexon is unknown. It has been suggested that azimexon may alkylate DNA. In cancer patients it increases leukocytosis, blood active T rosettes, T4/T8 ratio, and is used as an adjuvant to chemotherapy in the treatment of melanoma and myeloma." + }, + { + "input": "Concept: IBR (Regimen Used to Treat Chronic Lymphocytic Leukemia)", + "output": "something described as a chemoimmunotherapy regimen consisting of bendamustine, idelalisib and rituximab that can be used in the treatment of relapsed/refractory chronic lymphocytic leukemia (CLL)." + }, + { + "input": "Concept: AMERICAN INDIAN OR ALASKA NATIVE (Underrepresented Minority)", + "output": "Racial group described as a person having origins in any of the original peoples of North and South America (including Central America), and who maintains tribal affiliation or community attachment." + }, + { + "input": "Concept: 11: 65236065-65243651 (Spatial Concept)", + "output": "Chromosome 11 Physical Location described as physical location of HTATIP_Gene" + }, + { + "input": "Concept: Monocyte, Activated Killer (Cell)", + "output": "something described as monocytes made cytotoxic by IN VITRO incubation with CYTOKINES, especially INTERFERON-GAMMA. The cells are used for ADOPTIVE IMMUNOTHERAPY in cancer patients." + }, + { + "input": "Concept: Injection Site Thrombophlebitis (Thrombophlebitis)", + "output": "something described as thrombophlebitis in the veins surrounding an injection site." + }, + { + "input": "Concept: sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity (Molecular Function)", + "output": "something described as catalysis of the reaction: sn-glycerol 3-phosphate + ubiquinone-8 = glycerone phosphate + ubiquinol-8." + }, + { + "input": "Concept: PROVIDENCIA (Bacterium)", + "output": "Bacterium described as any bacteria that is not assigned to the species level but can be assigned to the Providencia genus level." + }, + { + "input": "Concept: URGENT (Therapeutic procedure)", + "output": "something described as deferring an urgent procedure increases risk of adverse outcome or clinical deterioration. Clinical situation warrants performing urgent procedures during the current episode of care to avoid compromising patient safety." + }, + { + "input": "Concept: Bundle, Kent (Conduction disorder of the heart)", + "output": "Conduction disorder of the heart described as extra impulse-conducting tissue in the heart that creates abnormal impulse-conducting connections between HEART ATRIA and HEART VENTRICLES." + }, + { + "input": "Concept: regulation of macrophage migration (regulation of leukocyte migration)", + "output": "something described as any process that modulates the frequency, rate or extent of macrophage migration." + }, + { + "input": "Concept: Theoretical Biology (Occupation or Discipline)", + "output": "something described as a field of biology that uses models and existing data and observations to explain some aspect of the biological world. The emphasis is on the production of ideas rather than data." + }, + { + "input": "Concept: PET complex location (Cell Component)", + "output": "something described as a protein complex that is composed of at least EXD1, TDRD12 and some PIWI protein. The complex is required for MILI slicing-triggered biogenesis and loading of MIWI2 piRNAs." + }, + { + "input": "Concept: TESTICLE EXCISION (Trunk excision)", + "output": "Complete excision described as surgical removal of one or both testicles." + }, + { + "input": "Concept: RXF 393 (Experimental Model of Disease)", + "output": "something described as a clear cell adenocarcinoma cell line established from a 54 year old male patient with renal cell carcinoma." + }, + { + "input": "Concept: Pulmonary emphysema (Physical & Psychosomatic Disorders)", + "output": "Lungs and Breathing described as a condition of the lung characterized by increase beyond normal in the size of air spaces distal to the terminal bronchioles, either from dilatation of the alveoli or from destruction of their walls." + }, + { + "input": "Concept: negative regulation of behavior (Organism Function)", + "output": "something described as any process that stops, prevents, or reduces the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." + }, + { + "input": "Concept: Cardiac myosin light chain 1 (Laboratory Procedure)", + "output": "something described as a measurement of myosin light chain 3 in a biological specimen." + }, + { + "input": "Concept: compartment pattern specification (anterior/posterior pattern specification)", + "output": "Organism Function described as the regionalization process in which embryonic segments are divided into compartments that will result in differences in cell differentiation." + }, + { + "input": "Concept: Marginal Adaptations, Dental (Orthodontics speciality)", + "output": "Therapeutic or Preventive Procedure described as the degree of approximation or fit of filling material or dental prosthetic to the tooth surface. A close marginal adaptation and seal at the interface is important for successful dental restorations." + }, + { + "input": "Concept: Boards, Bed (hospital bed accessories)", + "output": "hospital bed accessories described as a bed board is a device intended for medical purposes that consists of a stiff board used to increase the firmness of a bed." + }, + { + "input": "Concept: PI4K-BETA (PI4KB gene)", + "output": "Gene or Genome described as human PI4KB wild-type allele is located within 1q21 and is approximately 36 kb in length. This allele, which encodes phosphatidylinositol 4-kinase beta protein, plays a role in the phosphorylation of phosphatidylinositol to initiate production of the second messenger inositol-1,4,5,-trisphosphate." + }, + { + "input": "Concept: Density (Kind of quantity)", + "output": "Physical Phenomenon or Property described as a measurement of the compactness of a biological specimen expressed in mass per unit volume." + }, + { + "input": "Concept: Intractable diarrhea with choanal atresia and eye anomaly syndrome (Chronic disease of respiratory system)", + "output": "Eye Abnormalities described as this syndrome is characterized by the association of intractable diarrhea of infancy with choanal atresia. Short stature, a prominent and broad nasal bridge, micrognathia, single palmar creases, chronic corneal inflammation, cytopenia, and abnormal hair texture were also reported. So far, the syndrome has been described in three children from the same family. The absence of intellectual deficit and immune deficiency allow this syndrome to be distinguished from other forms of intractable diarrhea of infancy described previously." + }, + { + "input": "Concept: BLOOD COAG FACTOR X (Amino Acid, Peptide, or Protein)", + "output": "something described as storage-stable glycoprotein blood coagulation factor that can be activated to factor Xa by both the intrinsic and extrinsic pathways. A deficiency of factor X, sometimes called Stuart-Prower factor deficiency, may lead to a systemic coagulation disorder." + }, + { + "input": "Concept: CYCLOTRON, MEDICAL (Medical Device)", + "output": "Medical Device described as a medical charged-particle radiation therapy system is a device that produces by acceleration high energy charged particles (e.g., electrons and protons) intended for use in radiation therapy. This generic type of device may include signal analysis and display equipment, patient and equipment supports, treatment planning computer programs, component parts, and accessories." + }, + { + "input": "Concept: UDPglucose:2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucosyltransferase activity (phenol beta-glucosyltransferase activity)", + "output": "phenol beta-glucosyltransferase activity described as catalysis of the reaction: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one + UDP-D-glucose = 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one 2-D-glucoside + UDP." + }, + { + "input": "Concept: Report Version Due Date (Temporal Concept)", + "output": "Temporal Concept described as the date (and time) on which the report is expected or scheduled to be submitted." + }, + { + "input": "Concept: NACC2 Gene (Gene or Genome)", + "output": "Gene or Genome described as this gene plays a role in the modulation of cell proliferation." + }, + { + "input": "Concept: Gene Flow (Genetic Function)", + "output": "Genetic Function described as the change in gene frequency in a population due to migration of gametes or individuals (ANIMAL MIGRATION) across population barriers. In contrast, in GENETIC DRIFT the cause of gene frequency changes are not a result of population or gamete movement." + }, + { + "input": "Concept: MOXIFLOXACIN (Anti-Bacterial Agents)", + "output": "Antibiotics described as a drug used to treat bacterial infections. It is a type of fluoroquinolone." + }, + { + "input": "Concept: extraction procedure (Therapeutic or Preventive Procedure)", + "output": "Surgical Manipulation described as the act of taking out, extracting, or withdrawing an entity from a location." + }, + { + "input": "Concept: GAD-7 Version 2 - Worrying Too Much About Things (Intellectual Product)", + "output": "Intellectual Product described as generalized Anxiety Disorder - 7 Version 2 - Worrying too much about different things." + }, + { + "input": "Concept: Mixed type autoimmune hemolytic anemia (Other autoimmune hemolytic anemias)", + "output": "Autoimmune hemolytic anemia described as mixed autoimmune haemolytic anaemia (mixed AIHA) is a type of autoimmune haemolytic anaemia defined by the presence of both warm and cold autoantibodies, which have a deleterious effect on red blood cells at either body temperature or at lower temperatures. Diagnosis is based on clinical or laboratory evidence of haemolytic anaemia and the detection of autoantibodies, usually both IgG and IgM, with the direct anti-globulin test (DAT) showing a pattern of IgG with complement C3, and the presence of cold agglutinins (IgM) in the serum at a significant titre. The disease responds to corticosteroids, and may be followed by remission, but usually runs a chronic course with intermittent exacerbations." + }, + { + "input": "Concept: Hyptis (Plant)", + "output": "something described as a plant genus of the family LAMIACEAE that contains 5-methoxydehydropodophyllotoxin (a PODOPHYLLOTOXIN) and other LIGNANS." + }, + { + "input": "Concept: Unknown (Unknown)", + "output": "something described as it is unknown whether any transformation of the product takes place." + }, + { + "input": "Concept: nm (Quantitative Concept)", + "output": "something described as a measure of length in the metric system. A nanometer is one billionth of a meter. An average human hair is about 60,000 nanometers thick. Nanometers are used to measure wavelengths of light and distances between atoms in molecules." + }, + { + "input": "Concept: First Degree Family History Thyroid Cancer Negative (CPTAC Responses)", + "output": "CPTAC Responses described as there is no first degree family history of thyroid cancer." + }, + { + "input": "Concept: Proteoglycan (Extracellular Matrix Proteins)", + "output": "Amino Acid, Peptide, or Protein described as a molecule that contains both protein and glycosaminoglycans, which are a type of polysaccharide. Proteoglycans are found in cartilage and other connective tissues." + }, + { + "input": "Concept: Wirehaired Pointing Griffon (Dog family)", + "output": "Canis familiaris described as a rough-coated, medium-sized dog. It has a large, long head, square muzzle, and soft, thick, bushy eyebrows, beard and mustache. It has a straight, hard, wiry outer coat which is lined with a fine but thick downy undercoat. The coat comes in silver or steel-grey with chestnut or roam markings, or in solid chestnut. The average height range is 20-24 inches and the average weight range is 50-60 pounds." + }, + { + "input": "Concept: macrolide metabolic process (polyketide metabolic process)", + "output": "something described as the chemical reactions and pathways involving macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria." + }, + { + "input": "Concept: Material Integrity Problem (Device physical property issue)", + "output": "something described as problem associated with any deviations from the documented specifications of the device that relate to the limited durability of all material used to construct the device." + }, + { + "input": "Concept: FAC07540 (FACT-COG Version 3 Questionnaire Question)", + "output": "something described as functional Assessment of Cancer Therapy-Cognitive Function Version 3 (FACT-COG Version 3) Perceived Cognitive Abilities: Subscale score." + }, + { + "input": "Concept: Cells, Immunologic Accessory (Mononuclear phagocyte)", + "output": "Cell described as heterogeneous group of immunocompetent cells that mediates the cellular immune response by processing and presenting antigens to the T-cell receptor; traditional antigen presenting cells include macrophages, dendritic cells, Langerhans cells, and B-lymphocytes; follicular dendritic cells are also considered to be antigen presenting cells by some." + }, + { + "input": "Concept: Seeds, Sprouted (Plant)", + "output": "something described as young plants produced at the completion of GERMINATION of SEEDS." + }, + { + "input": "Concept: anterior olfactory nucleus, lateral part (Body Part, Organ, or Organ Component)", + "output": "something described as one of five subdivisions of the anterior olfactory nucleus in the mouse ( Dong-2004 ) and the rat ( Swanson-2004 ); it is located lateral to the anterior part of the anterior commissure. The other four parts are: the external part of the anterior olfactory nucleus, the dorsal part of the anterior olfactory nucleus, the medial part of the anterior olfactory nucleus and the posteroventral part of the anterior olfactory nucleus.\\r\\n" + }, + { + "input": "Concept: Infection, Bloodstream (IMMUNOLOGY COMPONENT)", + "output": "Immunology described as systematic infection" + }, + { + "input": "Concept: Peptide Nanotube (Nanotubes)", + "output": "Cyclic Peptides described as NANOTUBES formed from cyclic peptides (PEPTIDES, CYCLIC). Alternating D and L linkages create planar rings that self assemble by stacking into nanotubes. They can form pores through CELL MEMBRANE causing damage to cells." + }, + { + "input": "Concept: Three Vessel Coronary Disease (Disease or Syndrome)", + "output": "something described as there was one of the following: Stenosis of greater than or equal to 70 percent reduction in diameter (or 50 percent reduction in cross-sectional area) in all three major epicardial vessels (anterior descending, posterior descending, circumflex) or their major branches; Stenosis of greater than or equal to 50 percent reduction in diameter of the left main and greater than or equal to 70 percent reduction in diameter, or 50 percent reduction in cross-sectional area of the right coronary artery with a right dominant or co-dominant circulation; Stenosis of greater than or equal to 50 percent reduction in diameter of the left main with a left dominant circulation." + }, + { + "input": "Concept: CARCINOMA, RENAL, TUBULAR, MALIGNANT (Renal carcinoma)", + "output": "Renal carcinoma described as a malignant neoplasm of the kidney, characterized by the presence of tubules." + }, + { + "input": "Concept: Magnaporthe (Fungus)", + "output": "Ascomycota described as a genus of FUNGI, in the family Magnaporthaceae of uncertain position (incertae sedis). It is best known for its species, M. grisea, which is one of the most popular experimental organisms of all fungal plant pathogens. Its anamorph is PYRICULARIA GRISEA." + }, + { + "input": "Concept: Intraarticular use (Functional Concept)", + "output": "RouteBySite described as administration within a joint." + }, + { + "input": "Concept: Polyomavirus JC Infection (Virus Diseases)", + "output": "something described as an infection that is caused by JC virus." + }, + { + "input": "Concept: QUALITATIVE FOOD CONSUMPTION (Qualitative Evaluation)", + "output": "Qualitative Evaluation described as a qualitative or semi-quantitative measurement of a subject's nutritional intake." + }, + { + "input": "Concept: Dicarboxylate (carboxylate)", + "output": "Chemical categorised functionally described as acid or salt containing two carboxyl (=COOH) groups." + }, + { + "input": "Concept: FAC07517 (FACT-COG Version 3 Questionnaire Question)", + "output": "something described as functional Assessment of Cancer Therapy-Cognitive Function Version 3 - Perceived Cognitive Impairments: I have had to work harder than usual to express myself clearly." + }, + { + "input": "Concept: Adenomatoid ameloblastoma (Benign Neoplasm)", + "output": "Odontogenic tumor, benign described as a benign, slow growing neoplasm arising from tooth-forming tissues. The vast majority of cases are intraosseous and most often grow in the maxilla. It is characterized by the presence of odontogenic epithelium which is embedded in a connective tissue stroma. Local excision is curative and recurrences are very rare." + }, + { + "input": "Concept: spectrophotometer (Medical Device)", + "output": "something described as photometers that determine the absorbance or transmission of the light energy transmitted through a solution (or a gas) at any narrow adjustable (typically from 0.1 to 10 nm) bandwidth. Their principal components are a stable light source, a dispersing device (grating or prism monochromator), a cuvette, an adjustable slit, a photodetector, appropriate electronics to process the detector signal, and a means of displaying the results. These instruments have clinical applications primarily for the quantitative analysis of biological substances and enzymes or drugs and their metabolites in specimens." + }, + { + "input": "Concept: Heterodimeric Interleukin-15 (Antineoplastic Biological Agent)", + "output": "Pharmacologic Substance described as a fusion protein complex composed of heterodimeric IL-15 (hetIL-15), which consists of a synthetic form of the endogenous cytokine interleukin-15 chain (IL-15) complexed to the soluble IL-15 binding protein IL-15 receptor alpha chain (IL-15Ra) (IL15:sIL-15Ra), with potential immunomodulatory, anti-infective and antineoplastic activities. Upon administration, hetIL-15 binds to the IL-2/IL-15 receptor beta-common gamma chain (IL-2Rbeta-gamma) receptor on natural killer (NK) and T-lymphocytes, which activates and increases the levels of NK cells and CD8+ and CD4+ T-cells. The T-cells enhance the secretion of the cytokine interferon-gamma (IFN-g), which further potentiates the immune response against tumor cells. Altogether, this enhances tumor cell killing and decreases tumor cell proliferation. By coupling IL-15 to IL15Ra, this agent has an improved pharmacokinetic profile, shows an increased ability to bind IL-2Rbeta-gamma, and shows increased immunostimulatory activity as compared to IL-15 alone." + }, + { + "input": "Concept: LUNG, LEFT, INFERIOR LOBE, SUPERIOR SEGMENT (Respiratory System Part)", + "output": "Respiratory System Part described as the superior segment of the inferior lobe of the left lung." + }, + { + "input": "Concept: Aflatoxin (Organic Chemical)", + "output": "Benzopyrans described as furano-furano-benzopyrans that are produced by ASPERGILLUS from STERIGMATOCYSTIN. They are structurally related to COUMARINS and easily oxidized to an epoxide form to become ALKYLATING AGENTS. Members of the group include AFLATOXIN B1; aflatoxin B2, aflatoxin G1, aflatoxin G2; AFLATOXIN M1; and aflatoxin M2." + }, + { + "input": "Concept: Craniosacral Extension (Musculoskeletal extension)", + "output": "Organism Function described as motion occurring during the cranial rhythmic impulse when the sphenobasilar symphysis descends and sacral base moves anteriorly." + }, + { + "input": "Concept: Venous thromboembolism (Disease or Syndrome)", + "output": "something described as obstruction of a vein or VEINS (embolism) by a blood clot (THROMBUS) in the blood stream." + }, + { + "input": "Concept: Partial Volume Averaging (Idea or Concept)", + "output": "Idea or Concept described as a CT number underestimation artifact resulting from the presence of a dense object off center in a scan field." + }, + { + "input": "Concept: FACIT-Dyspnea 10 Item Short Form - Part I: Walk Up 20 Stairs Why Not (FACIT-Dyspnea 10 Item Short Form Questionnaire Question)", + "output": "Intellectual Product described as functional Assessment of Chronic Illness Therapy-Dyspnea 10 Item Short Form - Part I. Over the past 7 days, how short of breath did you get with each of these activities?: Walking up 20 stairs (2 flights) without stopping. Please indicate why you did not do this in the past 7 days." + }, + { + "input": "Concept: Delayed umbilical cord separation (Placenta and umbilical cord)", + "output": "Placenta and umbilical cord described as separation of the umbilical cord occurs at an abnormally late timepoint." + }, + { + "input": "Concept: Randomization Release Request (Document type)", + "output": "Intellectual Product described as records pertaining to the reversal of randomization code to reveal a specific subject's trial group allocation data." + }, + { + "input": "Concept: MYS (Geographic Area)", + "output": "Country described as southeast Asian country, capital Kuala Lumpur." + }, + { + "input": "Concept: Oriental herb and/or natural (Preparing and/or dispensing and/or training services with or without ICD diagnosis)", + "output": "Therapeutic or Preventive Procedure described as instructing and training a client to prepare and/or use an Oriental herb(s) and/or natural substance(s) for therapeutic purposes. Service is billed in 15-minute increments." + }, + { + "input": "Concept: Carcinoma of the Lacrimal Gland pT4b TNM Finding v7 (Carcinoma of the Lacrimal Gland pT4 TNM Finding v7)", + "output": "Finding described as carcinoma of the lacrimal gland with tumor invading orbital bone." + }, + { + "input": "Concept: Developing religiosity (Religiosity finding)", + "output": "Religiosity finding described as a pattern of reliance on religious beliefs and/or participation in rituals of a particular faith tradition, which can be strengthened." + }, + { + "input": "Concept: Superficial Thrombophlebitis (Cardio-vascular Findings: Peripheral Arteries)", + "output": "something described as inflammation of a superficial vein associated with venous thrombosis (blood clot formation within the vein)." + }, + { + "input": "Concept: Tatarstan (Geographic Area)", + "output": "Geographic Area described as political subdivision of eastern RUSSIA located within Europe. It lies between the Volga River and the Kama River, and extends east to the Ural mountains." + }, + { + "input": "Concept: glutamate synthase activity, NAD(P)H as acceptor (glutamate synthase activity)", + "output": "glutamate synthase activity described as catalysis of the reaction: 2 L-glutamate + NAD(P)+ = L-glutamine + 2-oxoglutarate + NAD(P)H + H+." + }, + { + "input": "Concept: Vomiting symptoms (Gastrointestinal symptom)", + "output": "Shock Severity: Anaphylactic described as expulsion of the contents of the stomach through the mouth." + }, + { + "input": "Concept: ADCS-ADL MCI - Use Household Appliance (ADCS-ADL MCI Questionnaire Question)", + "output": "Intellectual Product described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, MCI (ADCS-ADL MCI) In the past 4 weeks, did subject use a household appliance to do chores?" + }, + { + "input": "Concept: Biopsy palate (Diagnostic procedure on upper respiratory tract)", + "output": "Operation on palate described as removal of tissue from the palate for microscopic examination." + }, + { + "input": "Concept: Dir inj sperm into oocyt cytop (Fertilization in Vitro)", + "output": "Therapeutic or Preventive Procedure described as an assisted fertilization technique consisting of the microinjection of a single viable sperm into an extracted ovum. It is used principally to overcome low sperm count, low sperm motility, inability of sperm to penetrate the egg, or other conditions related to male infertility (INFERTILITY, MALE)." + }, + { + "input": "Concept: Brain Regeneration (Organ or Tissue Function)", + "output": "Natural regeneration described as endogenous repair and regeneration of the brain." + }, + { + "input": "Concept: Glycolysis (Energy Metabolism)", + "output": "Pyruvate Metabolism Pathway described as a metabolic process that converts GLUCOSE into two molecules of PYRUVIC ACID through a series of enzymatic reactions. Energy generated by this process is conserved in two molecules of ATP. Glycolysis is the universal catabolic pathway for glucose, free glucose, or glucose derived from complex CARBOHYDRATES, such as GLYCOGEN and STARCH." + }, + { + "input": "Concept: BAG, HEMOSTATIC (Medical Device)", + "output": "Medical Device described as a gastrointestinal tube and accessories is a device that consists of flexible or semi-rigid tubing used for instilling fluids into, withdrawing fluids from, splinting, or suppressing bleeding of the alimentary tract. This device may incorporate an integral inflatable balloon for retention or hemostasis. This generic type of device includes the hemostatic bag, irrigation and aspiration catheter (gastric, colonic, etc.), rectal catheter, sterile infant gavage set, gastrointestinal string and tubes to locate internal bleeding, double lumen tube for intestinal decompression or intubation, feeding tube, gastroenterostomy tube, Levine tube, nasogastric tube, single lumen tube with mercury weight balloon for intestinal intubation or decompression, and gastro-urological irrigation tray (for gastrological use)." + }, + { + "input": "Concept: Postneoadjuvant Therapy Stage I Gastroesophageal Junction Adenocarcinoma AJCC v8 (Gastroesophageal Junction Adenocarcinoma by AJCC v8 Postneoadjuvant Therapy Stage)", + "output": "something described as stage I includes: T0-2, N0, M0. T0: No evidence of primary tumor. T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis." + }, + { + "input": "Concept: Deoxyribosylthymine (Nucleotides)", + "output": "Deoxyribonucleosides described as a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose. As a constituent of DNA, thymidine pairs with adenine in the DNA double helix. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C880\" active clinical trials using this agent." + }, + { + "input": "Concept: Specimen.conditionCode (Intellectual Product)", + "output": "Intellectual Product described as a coded value specifying one of a discreet list of values describing the condition of the specimen at time of receipt at the lab. EXAMPLE(S): Hemolyzed, Icteric, Lipemic OTHER NAME(S): NOTE(S): Derived from PerformedObservationResult.value(ANY=>CD).code WHERE PerformedObservationResult > PerformedObservation > DefinedObservation.nameCode = \"assess specimen condition\"" + }, + { + "input": "Concept: elsiglutide (Pharmacologic Substance)", + "output": "something described as a synthetic glucagon-like peptide-2 (GLP-2) analogue with potential antidiarrheal and intestinotrophic activities. Upon subcutaneous administration, elsiglutide, a 39 amino acid polypeptide, binds to GLP-2 receptors and thereby promotes proliferation of epithelial cells. Regeneration of endothelial cells damaged during chemotherapy may prevent or decrease chemotherapy-induced diarrhea. In addition, elsiglutide may prevent chemotherapy-induced intestinal injury. GLP-2, a peptide hormone primarily produced in the small intestines in response to food, plays a key role in intestinal epithelial growth, metabolism and regeneration of epithelial cells." + }, + { + "input": "Concept: Increased connective tissue (Abnormality of connective tissue)", + "output": "MUSCLE SOFT, TISSUE described as the presence of an abnormally increased amount of connective tissue." + }, + { + "input": "Concept: Philtrum, Midline Sinus (Anatomical Abnormality)", + "output": "Anatomical Abnormality described as pit in the midline of the philtral groove." + }, + { + "input": "Concept: antibody-drug conjugate ABBV-176 (Immunologic Factor)", + "output": "Immunologic Factor described as an antibody-drug conjugate (ADC) composed of a proprietary monoclonal antibody against the prolactin receptor (PRLR) linked to an as of yet undisclosed cytotoxic agent, with potential antineoplastic activity. Upon intravenous administration, the monoclonal antibody moiety of ABBV-176 targets and binds to PRLR expressed on tumor cells. Upon binding and internalization, the cytotoxic agent is released and kills the PRLR-expressing tumor cells, through an as of yet unknown mechanism of action. PRLR, a tumor-associated antigen (TAA), is overexpressed by a variety of tumor cell types. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C137991\" active clinical trials using this agent." + }, + { + "input": "Concept: Fibrous Hamartoma (Connective tissue nevus, NOS)", + "output": "Mesenchymal hamartoma described as a rare, benign soft tissue tumor that typically occurs within the first two years of life." + }, + { + "input": "Concept: ENDOTHELIAL DIFFERENTIATION GENE 6 (Gene or Genome)", + "output": "Gene or Genome described as this gene encodes a G protein-coupled receptor that may be involved in cell migration processes in lymphocytes." + }, + { + "input": "Concept: PYROGLUTAMIC ACIDURIA (Defective phagocytic cell killing)", + "output": "Qualitative abnormality of granulocyte described as an autosomal recessive genetic disorder caused by mutation(s) in the GSS gene, encoding glutathione synthetase. Mutation(s) in the same gene is causative in hemolytic anemia due to glutathione synthetase deficiency, with the more severe condition causing elevated urinary concentrations of 5-oxoproline and central nervous system damage in addition to hemolytic anemia." + }, + { + "input": "Concept: Radially deviated phalanges (Radial deviation of the hand or of fingers of the hand)", + "output": "Finding described as bending or curvature of a finger toward the radial side (i.e., towards the thumb). The deviation is at the metacarpal-phalangeal joint, and this finding is distinct from clinodactyly." + }, + { + "input": "Concept: bombesin receptor activity (neuropeptide receptor activity)", + "output": "Molecular Function described as combining with bombesin to initiate a change in cell activity." + }, + { + "input": "Concept: THAILAND (Asia, Southeastern)", + "output": "something described as formerly known as Siam, this is a Southeast Asian nation at the center of the Indochina peninsula. Bangkok is the capital city." + }, + { + "input": "Concept: Anterior abdomen (Body Location or Region)", + "output": "something described as subdivision of abdomen which is demarcated from the back of the abdomen by the posterior surface of the anterior layer of the thoracolumbar fascia and the anterior surface of the lumbar vertebral column; together with the back of the abdomen, it constitutes the abdomen. Examples: There is only one front of abdomen." + }, + { + "input": "Concept: Birdshot choroidal lesions (Anatomical Abnormality)", + "output": "something described as multiple cream-yellow colored hypopigmented choroidal anomalies whose size is approximately one quarter to one half of that of the optic disc, and whose location tends to cluster around the optic nerve radiating towards the periphery. The pattern of the lesions is said to be similar to gunshot spatter from birdshot. []" + }, + { + "input": "Concept: prephenate hydro-lyase (hydro-lyase activity)", + "output": "something described as catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2." + }, + { + "input": "Concept: MSH, DROSOPHILA, HOMOLOG OF, 1 (Gene or Genome)", + "output": "Genes, Homeobox described as this gene is involved in transcriptional repression and embryogenesis." + }, + { + "input": "Concept: Antiprogesterone Therapy (Hormone Antagonists)", + "output": "Pharmacologic Substance described as a substance that blocks the activity of a progestin." + }, + { + "input": "Concept: Grade 4 Edema Neonatal (Neonatal Edema, Adverse Event)", + "output": "Neonatal Edema, Adverse Event described as life threatening consequences (e.g. respiratory failure, shock); requiring urgent major care changes (e.g. intubation, dialysis)." + }, + { + "input": "Concept: SGRQ01 (Clinical or Research Assessment Questionnaire)", + "output": "Clinical or Research Assessment Questionnaire described as st. George's Respiratory Questionnaire (SGRQ) Past 3 Months Version (copyright P.W. Jones, St. George's University of London)." + }, + { + "input": "Concept: Silver Recovery Systems, Ion-Exchange Cartridge (Medical Device)", + "output": "something described as equipment designed to recover silver from solutions by substituting ions in the solution for other ions bound to a large polymer molecule. The silver solution is passed through a packed resin cartridge (or column), and then the resin releases its exchange ion for an ion of higher preference; in photographic (or x-ray) film processing, it can be the silver thiosulfate complex. Once the ion-exchange cartridge is exhausted, an acid solution (typically low-concentrated sulfuric acid) is sent through the resin, breaking down the silver thiosulfate complex that is held by the resin. A well-controlled system can remove silver to less than one part per million (ppm). Ion-exchange systems are used mainly in healthcare facilities to recover silver from solutions used during radiographic film processing. This technique is intended to treat dilute solutions like wash water; systems are usually used to achieve very low silver content in disposed water according to regulatory limits." + }, + { + "input": "Concept: FAB, RHODAMINE, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)", + "output": "Indicator, Reagent, or Diagnostic Aid described as an immunoglobulin G (Fab fragment specific) immunological test system is a device that consists of the reagents used to measure by immunochemical techniques the Fab antigen-binding fragment resulting from breakdown of immunoglobulin G antibodies in urine, serum, and other body fluids. Measurement of Fab fragments of immunoglobulin G aids in the diagnosis of lymphoproliferative disorders, such as multiple myeloma (tumor of bone marrow cells), Waldenstrom's macroglobulinemia (increased immunoglobulin production by the spleen and bone marrow cells), and lymphoma (tumor of the lymphoid tissues)." + }, + { + "input": "Concept: Punches, Postmortem, Liver (Medical Device)", + "output": "Punch described as punches designed to excise a segment of tissue from the liver of a cadaver without performing an autopsy. These punches are typically handheld, manual instruments (resembling a stylet) that are appropriate for direct perforation of the abdominal wall and dissection of a liver sample. Postmortem liver punches are used mainly for diagnosis of yellow fever; they are not appropriate for biopsy of internal organs in living persons. The instruments also may be used to obtain samples of other internal organs from cadavers." + }, + { + "input": "Concept: Recognition, Visual Pattern (Form Perception)", + "output": "something described as mental process to visually perceive a critical number of facts (the pattern), such as characters, shapes, displays, or designs." + }, + { + "input": "Concept: positive regulation of male germ cell proliferation (positive regulation of germ cell proliferation)", + "output": "regulation of male germ cell proliferation described as any process that activates or increases the frequency, rate or extent of male germ cell proliferation." + }, + { + "input": "Concept: PODCI1-Gym Limited by: Health (Intellectual Product)", + "output": "Intellectual Product described as pediatric Outcomes Data Collection Instrument, Pediatric Parent-Reported - If you answered \"sometimes\" or \"never or rarely\" to Question 66 above, was your child's activity limited by: General health?" + }, + { + "input": "Concept: Phellodendrons (Amyridoideae)", + "output": "something described as a plant genus of the family RUTACEAE. Members contain BERBERINE, indolopyridoquinazoline and other ALKALOIDS and limonoids." + }, + { + "input": "Concept: MCT 5 (Gene or Genome)", + "output": "SLC16A4 gene described as human SLC16A4 wild-type allele is located in the vicinity of 1p13.3 and is approximately 28 kb in length. This allele, which encodes monocarboxylate transporter 5 protein, is involved in monocarboxylate transport across the plasma membrane." + }, + { + "input": "Concept: METACARPAL BONE 3 (Body Part, Organ, or Organ Component)", + "output": "something described as the third of five miniature long bones located in the palm of the hand, which articulates proximally with the capitate and second and fourth metacarpals at the carpometacarpal joint and distally with the middle finger phalanx at the metacarpophalangeal joint." + }, + { + "input": "Concept: Litter Size (Pregnancy, Animal)", + "output": "Pregnancy, Animal described as the number of offspring produced at one birth by a viviparous animal." + }, + { + "input": "Concept: FT-RFWT Version 1 TEST (CDISC Functional Test Terminology)", + "output": "Intellectual Product described as test names of functional test questions associated with the Rockport One Mile Walk Test Version 1.0 (RFWT Version 1) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: Induced Hypertension, Pregnancy (Hypertensive disease)", + "output": "Hypertension AND/OR vomiting complicating pregnancy childbirth AND/OR puerperium described as a blood pressure elevation after 20 weeks of gestation in the absence of either proteinuria or systemic findings like thrombocytopenia, impaired liver function, progressive renal insufficiency, pulmonary edema or the new-onset of cerebral or visual disturbances." + }, + { + "input": "Concept: epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types (Gene or Genome)", + "output": "something described as this gene is involved in epidermal integrity." + }, + { + "input": "Concept: up regulation of CRF receptor activity (Physiologic Function)", + "output": "regulation of corticotropin-releasing hormone receptor activity described as any process that activates or increases the frequency, rate or extent of corticotropin-releasing hormone receptor activity." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Serology, Bacteria, Brucella abortus, IgM Antibody (Medical Device)", + "output": "something described as serology reagents intended to detect immunoglobulin M (IgM) antibodies to Brucella abortus, a coccobacillus bacterium. These bacteria are an etiologic agent of brucellosis, a disease characterized by intermittent (i.e., undulant) fever." + }, + { + "input": "Concept: adult education (Education and/or schooling finding)", + "output": "Education and/or schooling finding described as formal or informal education for adults, including but not limited to basic education, high school equivalency, vocational education, correspondence courses, continuing education, non-degree coursework, and lifelong learning programs." + }, + { + "input": "Concept: Hypodeviation (Finding)", + "output": "something described as a type of strabismus in which the visual axis of one eye is lower than that of the other." + }, + { + "input": "Concept: Short outermost bone of toe (Anatomical Abnormality)", + "output": "Aplasia/Hypoplasia of the distal phalanges of the toes described as short distance from the end of the toe to the most distal interphalangeal crease or distal interphalangeal joint flexion point, i.e., abnormally short distal phalanx of toe." + }, + { + "input": "Concept: Stage III Carcinoma of the Hypopharynx (Stage III Pharynx Carcinoma)", + "output": "Neoplastic Process described as stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0) (T3, N1, M0). T3: Tumor more than 4 cm in greatest dimension or with fixation of hemilarynx. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 6th ed.) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C8040\" active clinical trials using this agent." + }, + { + "input": "Concept: Hypermagnesemia, CTCAE (Finding)", + "output": "Metabolism and Nutrition Disorders, CTCAE described as a disorder characterized by laboratory test results that indicate an elevation in the concentration of magnesium in the blood." + }, + { + "input": "Concept: Null Hypothesis Testing (Research Activity)", + "output": "Research Activity described as application of statistical tests to determine whether a null hypothesis should be accepted or rejected. Limited to discussions of statistical procedures." + }, + { + "input": "Concept: Child development: 6 months (Finding)", + "output": "milestones assessment described as milestones of physical, cognitive, and psychosocial progression by 6 months of age" + }, + { + "input": "Concept: NPI - Any Other Behaviors That Make Him/Her Hard to Handle (Intellectual Product)", + "output": "NPI Questionnaire Question described as neuropsychiatric Inventory (NPI) Does the patient have any other behaviors that make him/her hard to handle?" + }, + { + "input": "Concept: downregulation of antigen receptor-mediated signaling pathway (negative regulation of immune system process)", + "output": "negative regulation of signal transduction described as any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell." + }, + { + "input": "Concept: computer assisted patient care (biomedical automation)", + "output": "Health Care Activity described as monitoring, managing and scheduling of clinical care, including therapy, surgery, medications, etc." + }, + { + "input": "Concept: DNA double-strand break processing (Genetic Function)", + "output": "Genetic Function described as the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang." + }, + { + "input": "Concept: metronidazole vaginal (Metronidazole Vaginal Products)", + "output": "Metronidazole Vaginal Products described as a drug that treats bacterial and fungal infection" + }, + { + "input": "Concept: Intraductal Papillomatosis (Papilloma, Intraductal)", + "output": "Neoplasms, Ductal, Lobular, and Medullary described as a neoplastic process characterized by the presence of multiple intraductal papillomas." + }, + { + "input": "Concept: Surgical Graft Device (Device Component or Accessory)", + "output": "Device Component or Accessory described as a tissue or organ surgically moved from a donor to a recipient or from site to site of an individual." + }, + { + "input": "Concept: NTN (Gene or Genome)", + "output": "CX3CL1 gene described as human CX3CL1 wild-type allele is located within 16q13 and is approximately 13 kb in length. This allele, which encodes fractalkine precursor protein, plays a role chemotaxis, signal transduction and cellular adhesion." + }, + { + "input": "Concept: SGRQ02-Treatment Does Not Help Me Much (Intellectual Product)", + "output": "St George's Respiratory Questionnaire Past 4 Weeks Version Questionnaire Question described as st. George's Respiratory Questionnaire Past 4 Weeks Version - These are questions about your respiratory treatment: My treatment does not help me very much." + }, + { + "input": "Concept: Homework, function (Teaching & Teaching Methods)", + "output": "Educational Activity described as school work assigned for completion outside of school." + }, + { + "input": "Concept: Complices, Major Histocompatibility (HLA ANTIGENS: GENERAL TERMS)", + "output": "something described as genetic region found in all mammals whose products are primarily reponsible for the rapid rejection of grafts between individuals and which signal between lymphocytes and cells expressing antigen; H-2 in mouse and HLA in humans." + }, + { + "input": "Concept: Supercomputing (High Performance Computing)", + "output": "High Performance Computing described as pertaining to the fastest computers" + }, + { + "input": "Concept: GLOBBPT (Laboratory Procedure)", + "output": "something described as the determination of the ratio of beta globulin compared to total protein present in a sample. The measurement may be expressed as a ratio or percentage." + }, + { + "input": "Concept: visual photoreceptor (Sensory Receptor Cells)", + "output": "Cell described as cells specialized to detect and transduce light in the visual pathway." + }, + { + "input": "Concept: hyperparathyroidism; secondary (Parathyroid Diseases)", + "output": "Hyperparathyroid disorders described as overproduction of parathyroid hormone in response to influence external to the parathyroid glands." + }, + { + "input": "Concept: RRM (RNA-Binding Motifs)", + "output": "something described as an approximately 80 amino acid RNA binding motif that consists of four anti-parallel surface beta sheets and two alpha helices arranged in a beta-alpha-beta-beta-alpha-beta configuration. One of the surface beta sheets interacts with two or three specific RNA bases. Interactions between additional sequences and the RNA, as well as within the RNA recognition motif increase the affinity and specificity of the protein-RNA interaction." + }, + { + "input": "Concept: Comprehensive prolonged new in-office 150 minutes (New client in-office with ICD diagnosis)", + "output": "New client in-office with ICD diagnosis described as evaluating and managing a new client in a comprehensive, prolonged,150-minute, in-office meeting. This code may be used by providers of services who are able to diagnose." + }, + { + "input": "Concept: large kidney (Finding of size of kidney)", + "output": "Kidney described as an abnormal increase in the size of the kidney." + }, + { + "input": "Concept: Soft Collar Cervical Supports (Orthoses, Spine, Cervical)", + "output": "Medical Device described as cervical spine orthoses designed to provide support and some degree of movement restriction of the cervical segment of the spine. These orthoses usually consist of soft (usually prefabricated foam) structures encircling the neck (i.e., collars); they are frequently made of light plastic and/or other soft materials. Soft collar cervical spine support orthoses also provide limited restriction of head, neck, and cervical spine lateral and rotational motion; they are used mainly to alleviate pain and for short-term care of patients after injuries or surgery." + }, + { + "input": "Concept: striated muscle (Muscle Tissue)", + "output": "Serology described as striated muscles are appendicular and axial muscles typically connected at either or both ends to the bony skeleton of the body. Striated muscle fibers contain a highly organized, contractile cytoskeletal apparatus with a striated microscopic appearance; muscle contraction is typically under voluntary control." + }, + { + "input": "Concept: Sinus tachycardia (Finding)", + "output": "Finding described as a disorder characterized by a dysrhythmia with a heart rate greater than 100 beats per minute that originates in the sinus node." + }, + { + "input": "Concept: Centaurea L., 1753 (Plant)", + "output": "something described as a plant genus of the family ASTERACEAE. Members contain 5-methyl-8-hydroxycoumarin. The common name of centaury is more often used for CENTAURIUM" + }, + { + "input": "Concept: lymph vessel development (Organ or Tissue Function)", + "output": "anatomical structure development described as the process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure." + }, + { + "input": "Concept: Atherosclerotic (Functional Concept)", + "output": "something described as status similar or related to atherosclerosis" + }, + { + "input": "Concept: Mycobacterium malmoense Schroder and Juhlin 1977 (Genus Mycobacterium)", + "output": "Slow growing mycobacteria described as a species of slow-growing non-photochromogenic bacteria in the genus Mycobacterium. This species is a frequent cause of nontuberculous lung infections in norther Europe." + }, + { + "input": "Concept: 17q11.2-q12 (Chromosome band)", + "output": "Chromosome band described as a chromosome band present on 17q" + }, + { + "input": "Concept: 3: 10181630-10255723 (Chromosome 3 Physical Location)", + "output": "Spatial Concept described as physical location of IRAK2_Gene" + }, + { + "input": "Concept: SPIRIT (Allergen class)", + "output": "Allergen class described as an alcoholic beverage in which the initial fermentation mixture is distilled in order to concentrate the alcohol, generally resulting in a mixture that is at least 35% alcohol by volume." + }, + { + "input": "Concept: Nut, Fruit (Fruit)", + "output": "Nuts described as a dried fruit or fruit part that develops from a tree and is comprised of a hardened shell, which in true nuts is derived from the ovary wall of the plant, and an encapsulated, edible kernel or seed." + }, + { + "input": "Concept: Corrected (ActCode)", + "output": "Qualitative Concept described as having had errors or mistakes removed." + }, + { + "input": "Concept: Progressive spinal muscle atrophy (Motor Neuron Disease)", + "output": "Disease or Syndrome described as group of disorders marked by progressive degeneration of motor neurons in the spinal cord resulting in weakness and muscular atrophy, usually without evidence of injury to the corticospinal tracts." + }, + { + "input": "Concept: Plasmodium knowlesi, Asexual (Microbiology procedure)", + "output": "Laboratory Procedure described as a measurement of the Plasmodium knowlesi in an asexual replication stage in a biological specimen." + }, + { + "input": "Concept: Head Movements (Movement)", + "output": "Organism Function described as voluntary or involuntary motion of the head that may be relative to or independent of the body." + }, + { + "input": "Concept: COWS - Yawning (Intellectual Product)", + "output": "something described as clinical Opiate Withdrawal Scale - Yawning." + }, + { + "input": "Concept: Wall of thorax (Region of chest wall)", + "output": "Anterior thoracic region described as heterogeneous cluster which surrounds thoracic cavity and its content; and which includes the ribcage, muscle group of thoracic wall and costal pleura. Examples: There is only one thoracic wall." + }, + { + "input": "Concept: Hyaluronan-Mediated Motility Receptor Gene (HMMR gene)", + "output": "Gene or Genome described as human HMMR wild-type allele is located within 5q33.2-qter and is approximately 31 kb in length. This allele, which encodes hyaluronan mediated motility receptor protein, is involved in cellular motility and has been reported to mediate cellular migration." + }, + { + "input": "Concept: C-SSRS Children's Baseline - Non-Specific Active Suicidal Thoughts (Intellectual Product)", + "output": "Intellectual Product described as columbia-Suicide Severity Rating Scale Children's Baseline - Have you thought about doing something to make yourself not alive anymore? Have you had any thoughts about killing yourself?" + }, + { + "input": "Concept: teratoma; liver (Neoplastic Process)", + "output": "Liver Germ cell Tumor described as a teratoma that arises from the liver." + }, + { + "input": "Concept: Stage 0 Paranasal Sinus Cancer AJCC v8 (Neoplastic Process)", + "output": "something described as abnormal cells are found in the innermost lining of the maxillary sinus. These abnormal cells may become cancer and spread into nearby normal tissue." + }, + { + "input": "Concept: ACID PHOSPHATASE, THYMOL BLUE MONOPHOSPHATE (Indicator, Reagent, or Diagnostic Aid)", + "output": "something described as an acid phosphatase (total or prostatic) test system is a device intended to measure the activity of the acid phosphatase enzyme in plasma and serum." + }, + { + "input": "Concept: Abnormality of the glenoid fossa (Abnormality of the shoulder)", + "output": "Anatomical Abnormality described as an anomaly of the glenoid fossa, also known as the glenoid cavity, which is the articular surface of the scapula that articulates with the head of the humerus." + }, + { + "input": "Concept: RSSS01-Help If You Were Confined to Bed (RAND Social Support Survey Questionnaire Question)", + "output": "something described as RAND Social Support Survey Instrument (RAND Social Support Survey) How often is each of the following kinds of support available to you if you need it: Someone to help you if you were confined to bed." + }, + { + "input": "Concept: O2 Monitor Subassembly (Manufactured Object)", + "output": "Manufactured Object described as a sensor and circuit designed to sense the oxygen level in a space, environment, or material, as part of a larger device." + }, + { + "input": "Concept: General products and technology for the practice of religion or spirituality (Manufactured Object)", + "output": "Products and technology for the practice of religion and spirituality described as products and technology, unique or mass-produced, that are given or take on a symbolic meaning in the context of the practice of religion or spirituality, such as spirit houses, maypoles, headdresses, masks, crucifixes, menorahs and prayer mats, not adapted or specially designed." + }, + { + "input": "Concept: Clinical Efficacy (Effectiveness)", + "output": "Effectiveness described as power or capacity to produce a desired effect (i.e., appropriate pharmacological activity in a specified indication) in humans." + }, + { + "input": "Concept: MIR143 Pre-miRNA (Nucleic Acid, Nucleoside, or Nucleotide)", + "output": "Nucleic Acid, Nucleoside, or Nucleotide described as MIR143 pre-miRNA is an oligoribonucleotide that is encoded by the human MIR143 gene and has a role in the regulation of gene expression." + }, + { + "input": "Concept: Staining, Negative (Laboratory Procedure)", + "output": "Laboratory Procedure described as the technique of washing tissue specimens with a concentrated solution of a heavy metal salt and letting it dry. The specimen will be covered with a very thin layer of the metal salt, being excluded in areas where an adsorbed macromolecule is present. The macromolecules allow electrons from the beam of an electron microscope to pass much more readily than the heavy metal; thus, a reversed or negative image of the molecule is created." + }, + { + "input": "Concept: mutual help association (Organization administrative structures)", + "output": "Rehabilitation described as organized sources of information and assistance such as focused classes and organizations, telephone reassurance, and reliable Internet sites that address a specific topic such as parenting, alcoholism, obesity, and Alzheimer's disease." + }, + { + "input": "Concept: Solving problems (general concepts related to thought processes)", + "output": "Cognition described as finding solutions to questions or situations by identifying and analysing issues, developing options and solutions, evaluating potential effects of solutions, and executing a chosen solution, such as in resolving a dispute between two people." + }, + { + "input": "Concept: PYODERMA (Pyoderma)", + "output": "Dermatitis described as pus-producing skin infection" + }, + { + "input": "Concept: Lyophilisate and solvent for solution for injection (Biomedical or Dental Material)", + "output": "Biomedical or Dental Material described as sterile lyophilisate (freeze-dried powder) and sterile solvent intended for the preparation of a solution for injection, for veterinary use, by dissolving the lyophilisate in the solvent." + }, + { + "input": "Concept: Magnocellular tuberomammillary nucleus (Body Part, Organ, or Organ Component)", + "output": "something described as a composite structure of three cell groups found in the posterior hypothalamic region of the rat. It is defined on the basis of large oval cells that stain darkly for Nissl substance and also stain by immunohistochemistry for GAD and Met-Enk-Arg6-Phe7 heptapeptide. The cell groups include the ventral tuberomammillary nucleus, the dorsal tuberomammillary nucleus and the diffuse tuberomammillary nucleus. Together they form a 'shell' around ventral parts of the ventral premammillary nucleus, the lateral mammillary nucleus and the medial mammillary nucleus ( Koehler-1985 ). Functionally they are part of the behavioral state system ( Swanson-2004 )." + }, + { + "input": "Concept: Race: Other (Racial group)", + "output": "Racial group described as individuals who do not necessarily identify with any particular race or others who do not wish to self select into a racial category(ies)." + }, + { + "input": "Concept: POCF (Statistical Imputation)", + "output": "something described as the substitution of missing data with the next-to-last value that is not missing." + }, + { + "input": "Concept: Adiponectin Receptors (Receptors, Adipokine)", + "output": "Amino Acid, Peptide, or Protein described as cell surface receptors for ADIPONECTIN, an antidiabetic hormone secreted by ADIPOCYTES. Adiponectin receptors are membrane proteins with multiple cytoplasmic and extracellular regions. They are about 43 kDa and encoded by at least two genes with different affinities for globular and full-length adiponectin." + }, + { + "input": "Concept: Secondary Prostate Urothelial Carcinoma (Secondary malignant neoplasm of prostate)", + "output": "Neoplastic Process described as a transitional cell carcinoma that has spread to the prostate gland directly from the bladder." + }, + { + "input": "Concept: feet pes rockerbottom foot (Congenital malposition of talus)", + "output": "Congenital valgus deformity of foot described as the presence of both a prominent heel and a convex contour of the sole." + }, + { + "input": "Concept: Positive end Expiratory Pressure Valve Device (Manufactured Object)", + "output": "Valve Device described as a valve designed to work on a positive airway pressure device to maintain the positive pressure at the end of the respiratory cycle." + }, + { + "input": "Concept: EPIC-26 - Quality of Erections (EPIC-26 Questionnaire Question)", + "output": "EPIC-26 Questionnaire Question described as the Expanded Prostate Cancer Index Composite Short Form - How would you describe the usual quality of your erections during the last 4 weeks?" + }, + { + "input": "Concept: Microabscess (Acute necrotizing inflammation)", + "output": "Acute inflammation described as a very small, circumscribed collection of white blood cells, predominantly neutrophils." + }, + { + "input": "Concept: 5-(4-((6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)benzyl)-2,4-thiazolidinedione) - T (T [Preparations])", + "output": "Thiazolidinediones described as an orally-active thiazolidinedione with antidiabetic and hepatotoxic properties and potential antineoplastic activity. Troglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation." + }, + { + "input": "Concept: Maxillary Sinus Adenoid Cystic Carcinoma (Neoplastic Process)", + "output": "Neoplastic Process described as an adenoid cystic carcinoma that arises from the maxillary sinus. It usually has an aggressive clinical course." + }, + { + "input": "Concept: Ice Sheets (Geological Phenomena)", + "output": "Natural Phenomenon or Process described as a thick mass of ICE formed over large regions of land; RIVERS; LAKES; ponds; or SEAWATER." + }, + { + "input": "Concept: A2AR (G Protein-Coupled Receptor Genes)", + "output": "something described as this gene plays a regulatory role in the enzymatic activity of adenylyl cyclase." + }, + { + "input": "Concept: Asymmetric Cell Divisions (Cell Differentiation process)", + "output": "Cell Function described as the asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." + }, + { + "input": "Concept: Applicatorful Dosing Unit (Quantitative Concept)", + "output": "Non-SI unit of volume described as a dosing unit equal to the amount of active ingredient(s) contained in a full applicator." + }, + { + "input": "Concept: qualitative study (empirical study)", + "output": "Empirical Research described as any type of research that employs nonnumeric information to explore individual or group characteristics, producing findings not arrived at by statistical procedures or other quantitative means." + }, + { + "input": "Concept: Cellular Protein Targeting (Molecular Function)", + "output": "something described as the process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." + }, + { + "input": "Concept: RB1 NP 000312.2:p.Phe650Ser (RB1 Protein Variant)", + "output": "something described as a change in the amino acid residue at position 650 in the retinoblastoma-associated protein where phenylalanine has been replaced by serine." + }, + { + "input": "Concept: Inject (Intellectual Product)", + "output": "Intellectual Product described as a method of administration of a dose form by a parenteral route." + }, + { + "input": "Concept: Mucoepidermoid Carcinoma (Carcinoma of salivary gland type)", + "output": "Neoplastic Process described as a carcinoma morphologically characterized the presence of cuboidal mucous cells, goblet-like mucous cells, squamoid cells, cystic changes, and a fibrotic stromal formation. It can occur in several anatomic sites, including parotid gland, oral cavity, paranasal sinus, skin, breast, lung, larynx, and lacrimal ducts. It is classified as low or high grade." + }, + { + "input": "Concept: GASTROSCHISIS (Congenital malformations of musculoskeletal system, not elsewhere classified)", + "output": "Congenital Abnormality described as fissure of abdominal wall, not involving the umbilicus, and usually accompanied by protrusion of viscera which may or may not be covered by a membranous sac. (Makris S, Solomon HM, Clark R, Shiota K, Barbellion S, Buschmann J, Ema M, Fujiwara M, Grote K, Hazelden KP, Hew KW, Horimoto M, Ooshima Y, Parkinson M, Wise LD. Terminology of developmental abnormalities in common laboratory mammals (Version 2). Part B. Birth Defects Res B Dev Reprod Toxicol. 2009 Aug;86(4):227-327.)" + }, + { + "input": "Concept: negative regulation of methane biosynthetic process from dimethyl sulfide (negative regulation of alkane biosynthetic process)", + "output": "Molecular Function described as any process that stops, prevents or reduces the frequency, rate or extent of methane biosynthetic process from dimethyl sulfide." + }, + { + "input": "Concept: Cephalosporin Antibiotic (Drug allergens)", + "output": "Antibiotic described as a synthetic or semi-synthetic beta-lactam antibiotic derived from Acremonium (Cephalosporium) fungi with bactericidal activity. Cephalosporin antibiotics bind to and inactivate penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis." + }, + { + "input": "Concept: PADP - Pulmonary artery diastolic pressure (Pulmonary artery pressure)", + "output": "something described as the blood pressure in the pulmonary artery after the contraction of the heart while the chambers of the heart refill with blood." + }, + { + "input": "Concept: Dycal (Dental restorative material)", + "output": "Dental restorative material described as a proprietary, rigid, self-setting restorative material." + }, + { + "input": "Concept: MILIA (Milium Cyst)", + "output": "Tumor-like lesion of skin described as presence of multiple small cysts containing keratin (skin protein) and presenting as tiny pearly-white bumps just under the surface of the skin." + }, + { + "input": "Concept: Comparative Carcinogenesis (Biomedical Occupation or Discipline)", + "output": "Biomedical Occupation or Discipline described as the study of the similarities and differences between different living organisms of the process by which normal cells are transformed into cancer cells." + }, + { + "input": "Concept: Intrabursal route (Drug Administration Routes)", + "output": "Functional Concept described as administration within a bursa." + }, + { + "input": "Concept: Conjunctival Melanoma cT2a TNM Finding v8 (Conjunctival Melanoma cT2 TNM Finding v8)", + "output": "Finding described as conjunctival melanoma with noncaruncular tumor, and 1 or less quadrant of the nonbulbar conjunctiva involved." + }, + { + "input": "Concept: neuropathic pain (Chronic pain)", + "output": "something described as chronic pain caused by damage to nerve fibers. It is usually associated with tissue injury." + }, + { + "input": "Concept: APPARATUS, EXHAUST, SURGICAL (Device system)", + "output": "Device system described as clothing, frequently including a helmet, with accessory evacuation devices that permit recovery of shed body particles. Body exhaust systems are worn by surgical staff (e.g., for orthopedic procedures) in order to provide an ultraclean environment for the patient." + }, + { + "input": "Concept: giemsa stained (Special Histology Staining Method)", + "output": "something described as a microscopy staining method that utilizes Giemsa, a mixture of ethylene blue and eosin, which forms purplish-black crystals when dried. This stain preferentially binds to the phosphate groups of DNA and aggregates at areas with an increase in adenine-thymine binding, thus leading to chromosomal staining patterns that lend themselves to g-banding analysis. Additionally Giemsa can be used as a differential stain to determine microbial cell adherence to human cells as well as in the diagnosis of malaria, spirochete, and protozoal infections." + }, + { + "input": "Concept: Vegan (DIGESTIVE SYSTEM FUNCTIONS: GENERAL TERMS)", + "output": "something described as dietary practice of avoiding animal products in any form." + }, + { + "input": "Concept: CESTRTPT (Temporal Concept)", + "output": "Temporal Concept described as an indication or description of the start of a clinical event in relation to a specific point in time." + }, + { + "input": "Concept: CCND1 Splice Variant Present (Laboratory or Test Result)", + "output": "Laboratory or Test Result described as an indication that expression of a splice variant of CCND1 has been detected in a sample." + }, + { + "input": "Concept: Henipaviruses (Orthoparamyxovirinae)", + "output": "Paramyxovirinae described as any viral organism that can be assigned to the genus Henipavirus." + }, + { + "input": "Concept: Buxus, NOS (Plant)", + "output": "something described as a plant genus of the family BUXACEAE. Members contain steroidal alkaloids." + }, + { + "input": "Concept: Ego (Psychoanalytic Personality Factors)", + "output": "Personality Development described as the conscious portion of the personality structure which serves to mediate between the demands of the primitive instinctual drives, (the id), of internalized parental and social prohibitions or the conscience, (the superego), and of reality." + }, + { + "input": "Concept: Active Caries (Dental caries activity - finding)", + "output": "something described as progressing carious lesion." + }, + { + "input": "Concept: IMMUNOELECTROPHORETIC, IMMUNOGLOBULINS, (Medical Device)", + "output": "Medical Device described as an immunoglobulins A, G, M, D, and E immunological test system is a device that consists of the reagents used to measure by immunochemical techniques the immunoglobulins A, G, M, D, an E (serum antibodies) in serum. Measurement of these immunoglobulins aids in the diagnosis of abnormal protein metabolism and the body's lack of ability to resist infectious agents." + }, + { + "input": "Concept: SOAPR118 (SOAPP-R Questionnaire Question)", + "output": "SOAPP-R Questionnaire Question described as screener and Opioid Assessment for Patients with Pain - Revised (SOAPP-R) How often, in your lifetime, have you had legal problems or been arrested?" + }, + { + "input": "Concept: CDISC Questionnaire OAB-q Test Name Terminology (Intellectual Product)", + "output": "Intellectual Product described as test names of questionnaire questions associated with the overactive bladder questionnaire for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: Metaphyseal Dysplasia, Braun-Tinschert Type (Disease or Syndrome)", + "output": "something described as characterised by metaphyseal undermodelling with broadening of the long bones and femora with an 'Erlenmeyer flask' appearance, expansion and bowing of the radii with severe varus deformity and flat exostoses of the long bones at the metadiaphyseal junctions. It has been described in four German families originating from the same town in Bohemia and in a 7-year-old Japanese girl. Transmission is autosomal dominant." + }, + { + "input": "Concept: mcmol*day/mL (Measurement Unit Description)", + "output": "Measurement Unit Description described as days times micromoles per milliliter." + }, + { + "input": "Concept: liquid ventilation (Therapeutic or Preventive Procedure)", + "output": "something described as artificial respiration (RESPIRATION, ARTIFICIAL) using an oxygenated fluid." + }, + { + "input": "Concept: Bypass Gastrojejunostomy (Bypass of jejunum)", + "output": "Lower gastrointestinal procedure described as surgical procedure in which the stomach is connected to the jejunum, bypassing the duodenum." + }, + { + "input": "Concept: proximal dendrite (Cell Component)", + "output": "Cell Component described as the dendrite of the dendritic tree that is closest to the neuronal cell body (the soma)." + }, + { + "input": "Concept: RADIOIMMUNOASSAY, DIGITOXIN (125-I), RABBIT ANTIBODY, SOLID PHASE SEP. (Indicator, Reagent, or Diagnostic Aid)", + "output": "something described as a digitoxin test system is a device intended to measure digitoxin, a cardiovascular drug, in serum and plasma. Measurements obtained by this device are used in the diagnosis and treatment of digitoxin overdose and in monitoring levels of digitoxin to ensure appropriate therapy." + }, + { + "input": "Concept: positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide (Genetic Function)", + "output": "positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress described as any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrogen peroxide (H2O2) stimulus." + }, + { + "input": "Concept: SF-36 v2.0 Acute - Question 9g (Intellectual Product)", + "output": "something described as the Short Form 36 Health Survey Acute, Version 2.0 (SF36 v2.0 Acute) Question 9g." + }, + { + "input": "Concept: Ceratostigma willmottiana / cerato (Flower Essences)", + "output": "Flower Essences described as cerato." + }, + { + "input": "Concept: Cyclin G1 (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as a cyclin G subtype that is constitutively expressed throughout the cell cycle. Cyclin G1 is considered a major transcriptional target of TUMOR SUPPRESSOR PROTEIN P53 and is highly induced in response to DNA damage." + }, + { + "input": "Concept: CALCIUM TOTAL (Chemical procedure)", + "output": "Electrolytes measurement described as a measurement of the calcium in a biological specimen." + }, + { + "input": "Concept: 4'-iododeoxyrubicin (Anthracycline Antibiotics)", + "output": "Anthracycline Antibiotics described as a substance that is being studied as a treatment for cancer, and for primary systemic amyloidosis (a disease in which proteins are deposited in specific organs). It belongs to the family of drugs called anthracycline analogues." + }, + { + "input": "Concept: Curtains, Shower, Disposable (Manufactured Object)", + "output": "Shower curtain described as shower curtains designed to be used for a short period of time and then discarded, eliminating maintenance. These disposable curtains usually consist of a piece of lightweight plastic hung from a wall-mounted rod or a ceiling track; they are often manually operated. Some of these shower curtains are fire retardant and mildew, stain, and odor resistant. They are widely used at homes and healthcare facilities (e.g., nursing homes, hospitals, doctors' offices)." + }, + { + "input": "Concept: Shame (Emotional states)", + "output": "Emotional states described as a painful emotion resulting from a feeling of inadequacy, embarrassment, or guilt." + }, + { + "input": "Concept: MCF.2 Cell Line Derived Transforming Sequence (Signaling Pathway Gene)", + "output": "Signaling Pathway Gene described as this gene is involved in signal transduction." + }, + { + "input": "Concept: NMB Gene Product (peptide hormone)", + "output": "Amino Acid, Peptide, or Protein described as a protein encoded by the NMB gene." + }, + { + "input": "Concept: Auranofine (A [Preparations])", + "output": "Immunosuppressive Agents described as an orally available, lipophilic, organogold compound, used to treat rheumatoid arthritis, with anti-inflammatory and potential antineoplastic activities. Auranofin interacts with selenocysteine residue within the redox-active domain of mitochondrial thioredoxin reductase (TrxR), thereby blocking the activity of TrxR. As a result, this agent induces mitochondrial oxidative stress leading to the induction of apoptosis. Furthermore, this agent strongly inhibits the JAK1/STAT3 signal transduction pathway, thereby suppressing expression of immune factors involved in inflammation. TrxR, overexpressed in many cancer cell types, inhibits apoptosis, promotes cell growth and survival and plays a role in resistance to chemotherapy; TrxR catalyzes the reduction of oxidized thioredoxin (Trx) and plays a central role in regulating cellular redox homeostasis." + }, + { + "input": "Concept: Aminoglycoside Drugs (Drug allergens)", + "output": "ANTIBACTERIALS FOR SYSTEMIC USE described as any of a group of antibiotics derived from various species of Streptomyces or produced synthetically; they inhibit protein synthesis by binding with the 30S ribosomal subunit." + }, + { + "input": "Concept: Immunogenicity Specimen Assessments Result Standard Unit (Standard Result Unit)", + "output": "Quantitative Concept described as the standard unit of measure for the immunogenicity specimen assessment results." + }, + { + "input": "Concept: picokatal (Unit of Catalytic Activity)", + "output": "SI unit of catalytic amount described as a unit of catalytic activity measurement equal to trillionth of katal (10E-12 katal)." + }, + { + "input": "Concept: Artificial Airway Humidifiers (Household humidifier, device)", + "output": "Medical Device described as humidifiers designed to add moisture to the gases flowing in the inspiratory artificial airways, thus increasing the humidity of the gas delivered into the lungs. The humidifiers are inserted in the inspiratory lines typically leading from the outlet of a critical care or anesthesia ventilator. These humidifiers can introduce moisture either by forcing the incoming gas through the water in a heated reservoir of sterile water (bubble-through units), or by passing the incoming gas over the surface of a water reservoir (pass-over humidifier) or over a wet wick (wick humidifier, a variation of the pass-over humidifier). Artificial airway humidifiers are intended mainly for use when an artificial airway supplies air through devices such as tracheostomy or endotracheal tubes, bypassing the normal humidification process for respired gases." + }, + { + "input": "Concept: meiotic DNA double-strand break resectioning (cellular macromolecule metabolic process)", + "output": "something described as the process following clipping in double-strand break processing of SPO11 induced breaks, where long-tract single-stranded 3'-end DNA is generated from naked (SPO11 has been removed) 5' ends." + }, + { + "input": "Concept: Docosatetraenoic Acid n-3 (Organic Chemical)", + "output": "something described as polyunsaturated fatty acid with 22 carbons and 4 double bonds at the 3rd, 6th, 9th and 12th carbons from the methyl end." + }, + { + "input": "Concept: ADL0306A (Intellectual Product)", + "output": "ADCS-ADL MCI Questionnaire Question described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, MCI (ADCS-ADL MCI) If yes, which best describes the most complicated things that he or she wrote." + }, + { + "input": "Concept: Myopathy with lactic acidosis and sideroblastic anemia (Hereditary disorder of cellular element of blood)", + "output": "Autosomal recessive hereditary disorder described as belongs to the heterogeneous family of metabolic myopathies. It is characterized by progressive exercise intolerance manifesting in childhood, onset of sideroblastic anemia around adolescence, lactic acidemia and mitochondrial myopathy. Less than 10 cases have been described so far. A 656C-->T mutation in the nuclear pseudouridine synthase 1 gene (PUS1), localized to 12q24.33, has recently been identified in some patients. Deficient pseudouridylation of mitochondrial tRNAs may be responsible for the oxidative phosphorylation disorder. Transmission is autosomal recessive." + }, + { + "input": "Concept: Passive Stretching (Therapeutic or Preventive Procedure)", + "output": "something described as a technique in which one is relaxed and makes no contribution to the range of motion. Instead, an external force is used to achieve the stretching. A position is held by another body part or person, or an apparatus." + }, + { + "input": "Concept: Antibacterial drugs (Anti-Infective Agents)", + "output": "Antibiotic described as a substance that kills bacteria or stops them from growing and causing disease." + }, + { + "input": "Concept: Operator (Intellectual Product)", + "output": "Intellectual Product described as a symbol used to perform an arithmetic or logical operation." + }, + { + "input": "Concept: base-excision repair, gap-filling (DNA metabolic process)", + "output": "DNA metabolic process described as repair of the damaged strand by the combined action of an apurinic endouclease that degrades a few bases on the damaged strand and a polymerase that synthesizes a 'patch' in the 5' to 3' direction, using the undamaged strand as a template." + }, + { + "input": "Concept: didemethylisoproturon amidohydrolase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)", + "output": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides described as catalysis of the reaction: didemethylisoproturon + H2O = carbamic acid + 4-isopropylaniline." + }, + { + "input": "Concept: regulation of cellular response to X-ray (regulation of response to stimulus)", + "output": "regulation of response to stimulus described as any process that modulates the frequency, rate or extent of cellular response to X-ray." + }, + { + "input": "Concept: Malignant Ovarian Transitional Cell Neoplasm (Malignant Ovarian Surface Epithelial-Stromal Tumor)", + "output": "Ovarian Transitional Cell Tumor described as an invasive malignant neoplasm that arises from the ovary and is characterized by the presence of malignant epithelial cells that resemble malignant urothelial cells. It includes transitional cell carcinoma and malignant Brenner tumor." + }, + { + "input": "Concept: PEX5-Related Protein (Regulatory Protein)", + "output": "Biologically Active Substance described as PEX5-related protein (626 aa, ~70 kDa) is encoded by the human PEX5L gene. This protein plays a role in the localization of hyperpolarization-activated cyclic nucleotide-gated channels." + }, + { + "input": "Concept: Proliferative Nodules in Congenital Melanocytic Nevus (Neoplastic Process)", + "output": "Neoplastic Process described as a benign proliferation of epithelioid or spindled melanocytes usually in the upper or mid dermis in a background of congenital melanocytic nevus. The congenital melanocytic nevus is usually of the deep type, involving the dermis and extending into the subcutaneous tissue. It presents as a dark plaque or nodule above a giant congenital melanocytic nevus." + }, + { + "input": "Concept: Clematis vitalba / clematis (Flower Essences)", + "output": "Flower Essences described as clematis." + }, + { + "input": "Concept: Insulinotropic Polypeptide Receptor, Glucose-Dependent Gene (Gene or Genome)", + "output": "GIPR gene described as human GIPR wild-type allele is located in the vicinity of 19q13.3 and is approximately 14 kb in length. This allele, which encodes gastric inhibitory polypeptide receptor protein, plays a role in the regulation of insulin secretion and other facets of the anabolic response." + }, + { + "input": "Concept: CSS11-Non-Spec Suicid Thought-P1M (C-SSRS Lifetime/Recent Version Questionnaire Question)", + "output": "something described as columbia-Suicide Severity Rating Scale Lifetime/Recent Version (C-SSRS Lifetime/Recent Version) Have you actually had any thoughts of killing yourself? (Past 1 Month)." + }, + { + "input": "Concept: Salientia (Amphibian)", + "output": "Amphibian described as an amphibian in the order Anura, which includes the toads. The commonest frog genera are Rana (grass frogs) and Hyla (tree frogs)." + }, + { + "input": "Concept: Betamethasonum (anti-inflammatory steroids)", + "output": "Corticosteroids, topical for treatment of hemorrhoids and anal fissures described as a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory activities. Betamethasone binds to specific intracellular glucocorticoid receptors and subsequently binds to DNA to modify gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited. As a result, there is an overall reduction in chronic inflammation and autoimmune reactions." + }, + { + "input": "Concept: Immunoglobin A Phospholipid Unit per Milliliter (Unit of Arbitrary Substance Concentration)", + "output": "Quantitative Concept described as a unit for semiquantitative measurement of IgA autoantibodies to proteins associated with negatively charged phospholipids evaluated against an established reference standard, per unit of volume equal to one milliliter." + }, + { + "input": "Concept: BILATERAL SIMULTANEOUS (Therapeutic or Preventive Procedure)", + "output": "something described as a type of radiation procedure in which radiation is applied to both halves of the body or body part at the same time." + }, + { + "input": "Concept: Resectable Malignant Pleural Mesothelioma (Resectable Malignant Mesothelioma)", + "output": "Neoplastic Process described as malignant mesothelioma of the pleura that is amenable to surgical resection." + }, + { + "input": "Concept: SOWS Subjective (Handelsman) - I Am Shaking (Intellectual Product)", + "output": "something described as subjective Opiate Withdrawal Scale - I am shaking." + }, + { + "input": "Concept: Mixed Antigen IgE Antibody RAST Score (Immunoglobulin E measurement)", + "output": "Laboratory Procedure described as a classification of the amount of mixed antigen IgE antibody, using the RAST (radioallergosorbent test) scoring system, in a biological specimen." + }, + { + "input": "Concept: Heparin-Binding Growth Factor (Biologically Active Substance)", + "output": "Growth Factor described as mitogenic factors with high affinity for heparin. These proteins regulate the proliferation and differentiation of mesenchymal, epithelial, and neuroectodermal cells. Heparin-binding may sequester these proteins in the extracellular matrix, or increase the stability of these growth factors. Heparin may enhance the activity of some family members, as it may be required for their interactions with cellular receptors." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, FGFR1 (Medical Device)", + "output": "something described as molecular assay reagents intended to identify deletions or duplications of the fibroblast growth factor receptor 1 (FGFR1) gene, located at chromosome 8p11.23-p11.22, which encodes the protein fibroblast growth factor receptor 1. Genetic variants at this locus have been associated with Pfeiffer syndrome, Kallmann syndrome, Jackson-Weiss syndrome, encephalocraniocutaneous lipomatosis, trigonocephaly, and osteoglophonic dysplasia." + }, + { + "input": "Concept: Soluble fiber modified diet (Modified fiber diet)", + "output": "Therapeutic or Preventive Procedure described as increase or decrease in soluble fiber content of the diet." + }, + { + "input": "Concept: PTMA protein, human (Amino Acid, Peptide, or Protein)", + "output": "Immunoproteins described as prothymosin alpha (111 aa, ~12 kDa) is encoded by the human PTMA gene. This protein may play a role in the regulation of apoptosis." + }, + { + "input": "Concept: CCNS (Professional or Occupational Group)", + "output": "something described as a registered nurse who has a master's or doctorate degree in a clinical field of nursing and has been certified by the Board of Registered Nursing." + }, + { + "input": "Concept: negative regulation of stress response to copper ion (negative regulation of response to stimulus)", + "output": "regulation of stress response to copper ion described as any process that stops, prevents or reduces the frequency, rate or extent of stress response to copper ion." + }, + { + "input": "Concept: Preventive Clinical Trial (Trial Indication Type)", + "output": "Trial Indication Type described as a type of study designed to identify actions necessary to permanently eliminate or reduce the long-term risk to human life as a result of a particular medication or treatment regimen." + }, + { + "input": "Concept: Okras (Food)", + "output": "something described as fruit of Abelmoschus esculentus." + }, + { + "input": "Concept: reproductive behavior in a multicellular organism (Behavior)", + "output": "something described as human behavior or decision related to REPRODUCTION." + }, + { + "input": "Concept: Total Volume Administration Unit (Intellectual Product)", + "output": "Intellectual Product described as a terminology subset of the CDISC SDTM Unit codelist created for CDASH Total Volume Administration Unit codelist." + }, + { + "input": "Concept: regulation of neuron differentiation (regulation of neurogenesis)", + "output": "Cell Function described as any process that modulates the frequency, rate or extent of neuron differentiation." + }, + { + "input": "Concept: arterial blood gas panel (Measurement of level of substance in blood)", + "output": "Blood Gas Analysis described as measures the acidity (pH) and the levels of oxygen, carbon dioxide, and bicarbonate in the blood." + }, + { + "input": "Concept: PerformedStudySubjectMilestone.informedConsentIndicator (Functional Concept)", + "output": "Informed Consent Indicator described as specifies whether the study subject gave official consent by signing the official consent form. EXAMPLE(S): OTHER NAME(S): NOTE(S): Derived from the existence of PerformedStudySubjectMilestone.dateRange WHERE PerformedActivity > DefinedActivity.nameCode = \"obtain informed consent\"." + }, + { + "input": "Concept: Incontinence NOS (Urinary Bladder)", + "output": "Gastrointestinal signs and symptoms NEC described as involuntary passage of stool or urine from the body." + }, + { + "input": "Concept: StorageEquipment.temperatureCapabilityRange (Quantitative Concept)", + "output": "Temperature Capability Range described as the maximum and minimum thermal settings at which the storage unit can be set. EXAMPLE(S): <= -80 degrees celsius -135 to -80 degrees celsius -150 to -135 degrees celsius > -150 degrees celsius OTHER NAME(S): NOTE(S):" + }, + { + "input": "Concept: L-aspartate:fumarate oxidoreductase activity (oxidoreductase activity, acting on the CH-NH2 group of donors)", + "output": "something described as catalysis of the reaction: L-aspartate + fumarate = alpha-iminosuccinate + succinate." + }, + { + "input": "Concept: lactate formation from pyruvate (lactate biosynthetic process)", + "output": "Pyruvate Metabolism Pathway described as the chemical reactions and pathways resulting in the formation of lactate from other compounds, including pyruvate." + }, + { + "input": "Concept: Capital, Social (Sociological Factors)", + "output": "Sociological Factors described as investing in social relationships by establishing trust, norms, and networks to create social cohesion and facilitate cooperative communities." + }, + { + "input": "Concept: Postpartum Shock (Shock)", + "output": "something described as severe loss of blood pressure leading to inadequate tissue perfusion after the delivery of the fetus." + }, + { + "input": "Concept: Benzaldehyde dehydrogenase (Enzyme)", + "output": "something described as an NADP+ dependent enzyme that catalyzes the oxidation of benzaldehyde to BENZOIC ACID. It also plays a role in the degradation of TOLUENE and XYLENE." + }, + { + "input": "Concept: Nuclear Reactors (Manufactured Object)", + "output": "Power Plants described as devices containing fissionable material in sufficient quantity and so arranged as to be capable of maintaining a controlled, self-sustaining NUCLEAR FISSION chain reaction. They are also known as atomic piles, atomic reactors, fission reactors, and nuclear piles, although such names are deprecated." + }, + { + "input": "Concept: Dental Microabrasions (Esthetics, Dental)", + "output": "Therapeutic or Preventive Procedure described as mechanical removal of a small amount of tooth structure (not more than a few tenths of a millimeter in depth) to eliminate superficial enamel discoloration defects not successfully removed by bleaching techniques. A common abrasive is a mixture of pumice and hydrochloric acid." + }, + { + "input": "Concept: LIFT, PATIENT, AC-POWERED (Medical Device)", + "output": "something described as an AC-powered lift is an electrically powered device either fixed or mobile, used to lift and transport patients in the horizontal or other required position from one place to another, as from a bed to a bath. The device includes straps and slings to support the patient." + }, + { + "input": "Concept: cellular response to vitamin K1 (cellular response to ketone)", + "output": "something described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phylloquinone (vitamin K1) stimulus." + }, + { + "input": "Concept: Suture of palate (Procedure on palate)", + "output": "Repair of palate described as surgery to repair a cleft palate." + }, + { + "input": "Concept: SMAD family member 3 (Gene or Genome)", + "output": "something described as this gene is involved in signal transduction and apoptosis. It also plays a role in the regulation of both steroid synthesis and T-cell response." + }, + { + "input": "Concept: Biosynthesis Initiation, Protein (Protein Biosynthesis)", + "output": "Genetic Function described as a process of GENETIC TRANSLATION whereby the formation of a peptide chain is started. It includes assembly of the RIBOSOME components, the MESSENGER RNA coding for the polypeptide to be made, INITIATOR TRNA, and PEPTIDE INITIATION FACTORS; and placement of the first amino acid in the peptide chain. The details and components of this process are unique for prokaryotic protein biosynthesis and eukaryotic protein biosynthesis." + }, + { + "input": "Concept: Treatment of Infectious Disease (Supportive care)", + "output": "something described as treat infections with antibacterial, antifungal, antiparasite or antiviral drugs" + }, + { + "input": "Concept: Fetal-maternal haemorrhage NOS (Fetal finding)", + "output": "Foetal complications NEC described as transplacental passage of fetal blood into the circulation of the maternal organism." + }, + { + "input": "Concept: Prostate Carcinoma cT2b TNM Finding v8 (Prostate Cancer cT2 TNM Finding v8)", + "output": "something described as prostate cancer in which the tumor involves more than one-half of one side but not both sides." + }, + { + "input": "Concept: ribosomal protein L8, rat (Ribosomal Proteins)", + "output": "Ribosomal Proteins described as 60S ribosomal protein L8 (257 aa, ~28 kDa) is encoded by the human RPL8 gene. This protein is involved in protein translation." + }, + { + "input": "Concept: RECEPT SOMATOMEDIN (Receptor)", + "output": "Amino Acid, Peptide, or Protein described as the protein on surface of target cells specific for binding IGF. There are two types of IGF receptor, one of which closely resembles the insulin receptor." + }, + { + "input": "Concept: Dacryoadenitides (Disorder of lacrimal gland)", + "output": "something described as inflammation and enlargement of the lacrimal gland." + }, + { + "input": "Concept: 11p15.1-p14 (Chromosome band)", + "output": "Cell Component described as a chromosome band present on 11p" + }, + { + "input": "Concept: D22S673 (SERPIND1 gene)", + "output": "SERPIND1 gene described as human SERPIND1 wild-type allele is located in the vicinity of 22q11.21 and is approximately 14 kb in length. This allele, which encodes heparin cofactor 2 protein, is involved in heparin-dependent inhibition of thrombin. Mutation of the gene is associated with thrombophilia due to heparin cofactor 2 deficiency." + }, + { + "input": "Concept: Verbal Paired Associates I Subtest (Intellectual Product)", + "output": "Intellectual Product described as a subtest of the Wechsler Memory Scale, 4th Edition that evaluates verbal memory for associated word pairs. After 10 or 14 word pairs are read to the subject, the first word of each pair is read, and the subject is asked to provide the corresponding word." + }, + { + "input": "Concept: per Square Millimeter (Unit of Dose Calculation)", + "output": "Unit of Dose Calculation described as an area unit equal to one millimeter squared used as a denominator to build a derived unit expressed as a ratio." + }, + { + "input": "Concept: Siloxane (Polymers)", + "output": "Silicon Compounds, Inorganic described as silicon polymers that contain alternate silicon and oxygen atoms in linear or cyclic molecular structures." + }, + { + "input": "Concept: FMT - faecal microbiota transplant (Infection Prophylaxis and Management)", + "output": "Infection Prophylaxis and Management described as the transplantation of fecal bacteria, via enema, colonoscopy, or other method, from a healthy individual to a recipient. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C118643\" active clinical trials using this agent." + }, + { + "input": "Concept: Penile prepuce (Subdivision of perineum)", + "output": "Subdivision of perineum described as the loose skin that covers the head of the penis." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, ACVRL1 (Medical Device)", + "output": "Medical Device described as molecular assay reagents intended to identify mutations in the activin A receptor type II-like 1 (ACVRL1) gene, located at chromosome 12q11-q14, which encodes for activin receptor-like kinase-1, a protein found on cell surfaces that acts as a receptor serine/threonine kinase. These receptors bind transforming growth factor beta (TGF-beta) and, possibly, activin. Mutations at this locus have been identified in patients with hereditary hemorrhagic telangiectasia type 2 (HHT2), also known as Osler-Rendu-Weber syndrome (ORW2)." + }, + { + "input": "Concept: HTLV WIII GP 160 (Biologically Active Substance)", + "output": "HIV envelope protein described as glycoprotein encoded by HIV envelope gene (env) with a molecular weight of 160,000 daltons." + }, + { + "input": "Concept: translational initiation (Genetic Translation Process)", + "output": "Genetic Translation Process described as the process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." + }, + { + "input": "Concept: Tethered cord syndrome (Spinal Cord Diseases)", + "output": "Syndrome described as a progressive neurological disorder characterized by the limitation of movement of the spinal cord within the spine. It is caused by the presence of congenital or acquired tissue attachments in the spinal cord. Signs and symptoms include low back pain, scoliosis, weakness in the legs, and incontinence." + }, + { + "input": "Concept: liposomal eribulin mesylate (Pharmacologic Substance)", + "output": "Vinca-Domain Binding Agent described as a liposome-encapsulated formulation of the mesylate salt form of eribulin, a synthetic, macrocyclic ketone analogue of halichondrin B, a substance derived from the marine sponge genus Halichondria, with potential antineoplastic activity. Eribulin binds to the vinca domain of tubulin and inhibits both the polymerization of tubulin and the assembly of microtubules. This results in the inhibition of mitotic spindle assembly, the induction of cell cycle arrest at G2/M phase, as well as tumor cell apoptosis. Compared to the administration of eribulin alone, liposomal delivery of eribulin allows for a longer half-life, which allows increased drug concentration in target tissues while decreasing systemic toxicity." + }, + { + "input": "Concept: foramen of Monro (Structure of diencephalon)", + "output": "Anatomical conduit described as the connection between the lateral ventricles with the third ventricle, which allows for the flow of CSF between the structures." + }, + { + "input": "Concept: Fosaprepitant dimeglumine (Substance with receptor antagonist mechanism of action)", + "output": "Organic Chemical described as a drug used together with other drugs to prevent and control nausea and vomiting caused by cancer treatment. It is given in a vein. It is a type of antiemetic and a type of substance P/neurokinin 1 receptor antagonist." + }, + { + "input": "Concept: wheelchair accessories (Medical Device)", + "output": "wheelchair described as a wheelchair accessory is a device intended for medical purposes that is sold separately from a wheelchair and is intended to meet the specific needs of a patient who uses a wheelchair. Examples of wheelchair accessories are the following: armboard, lapboard, pusher cuff, crutch and cane holder, restraint, overhead suspension sling, head and trunk support, and blanket and leg rest strap." + }, + { + "input": "Concept: Topical dosage form (Dosage Form By Route Of Administration)", + "output": "Dermatologic drugs described as a substance intended for administration to a body surface." + }, + { + "input": "Concept: CD2BP2 gene (Gene or Genome)", + "output": "Ligand Binding Protein Gene described as this gene plays a role in both spliceosome assembly and T-cell activation." + }, + { + "input": "Concept: pheniramine (Organic Chemical)", + "output": "P [Preparations] described as one of the HISTAMINE H1 ANTAGONISTS with little sedative action. It is used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus." + }, + { + "input": "Concept: Ordered association type reference set (Intellectual Product)", + "output": "Intellectual Product described as a type of reference set that allocates an order to a set of SNOMED CT associations." + }, + { + "input": "Concept: autoantibodies to insulin (serum autoantibodies)", + "output": "something described as the determination of the amount of insulin autoantibody in a biological specimen." + }, + { + "input": "Concept: Unit of Electric Flux Density (Quantitative Concept)", + "output": "Quantitative Concept described as a unit for measurement of vector-valued field that appears in Maxwell's equations." + }, + { + "input": "Concept: Preimplantation lethality (Abnormality of prenatal development or birth)", + "output": "something described as it is estimated that about 40-70 percent of human embryos produced in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are viable embryos, whereas others arrest at different early stages of development. The phenotype of preimplantation lethality is inferred if IVF and ICSI cycles fail because all of an individual's embryos are arrested at early stages of development." + }, + { + "input": "Concept: Oral Mucositis (Stomatitis)", + "output": "Inflammatory disorder of head described as inflammation or irritation of the mucous membranes in the mouth." + }, + { + "input": "Concept: Embryonal Tumor with Multilayered Rosettes, NOS (Central Nervous System Embryonal Neoplasm)", + "output": "Central Nervous System Embryonal Neoplasm described as a central nervous system embryonal neoplasm characterized by the presence of histological features consistent with embryonal tumor with multilayered rosettes and absence of C19MC amplification." + }, + { + "input": "Concept: Gestational Trophoblastic Neoplasm pT0 TNM Finding v8 (Gestational Trophoblastic Neoplasm Pathologic Primary Tumor TNM Finding v8)", + "output": "something described as gestational trophoblastic neoplasm with no evidence of primary tumor." + }, + { + "input": "Concept: craniofrontonasal dysplasia (Disease or Syndrome)", + "output": "Disease or Syndrome described as an X-linked malformation syndrome characterised by facial asymmetry (particularly orbital), body asymmetry, midline defects (hypertelorism, frontal bossing, broad grooved or bifid nasal tip, cleft lip and/or palate, high arched palate), skeletal anomalies (clavicle pseudoarthrosis, coronal craniosynostosis, various digital and limb anomalies including syndactyly, clinodactyly of the 5th finger, broad thumbs) and ectodermal dysplasias (dental anomalies, grooved nails, wiry hair)." + }, + { + "input": "Concept: negative regulation of metanephric glomerular mesangial cell proliferation (Cell Function)", + "output": "negative regulation of glomerular mesangial cell proliferation described as any process that decreases the frequency, rate or extent of metanephric glomerular mesangial cell proliferation." + }, + { + "input": "Concept: Cloaca (Bacterium)", + "output": "Enterobacter described as any bacteria that is not assigned to the species level but can be assigned to the Enterobacter genus level." + }, + { + "input": "Concept: Adult Anaplastic (Malignant) Meningioma (Neoplastic Process)", + "output": "Neoplastic Process described as an anaplastic (malignant) meningioma occurring in adults. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C8275\" active clinical trials using this agent." + }, + { + "input": "Concept: Rhaphidophora (Plant)", + "output": "Plant described as a perennial, evergreen, semisucculent epiphytic vine of Vietnam. Members contain benzoperoxide." + }, + { + "input": "Concept: recombinant chimeric human fusion protein TT30 (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as a recombinant, chimeric human fusion protein consisting of the iC3b/C3d-binding region of human complement receptor type 2 (CR2/CD21) linked to the alternative complement pathway (ACP) inhibitory domain of human factor H (fH) (CR2-fH), with potential complement system inhibiting activity. Via its C3 binding domain, TT30 selectively binds to complement activated cell surfaces and via its fH binding domain regulates ACP activity. This suppresses excessive complement activity and may result in an inhibition of ACP-mediated hemolysis of paroxysmal nocturnal hemoglobinuria (PNH) red blood cells (RBCs) as well as preventing ACP-induced tissue damage. Factor H is a key regulator in the activation of ACP." + }, + { + "input": "Concept: Retroperitoneal Soft Tissue Sarcoma Clinical TNM Finding v8 (Soft Tissue Sarcoma of the Retroperitoneum TNM Finding v8)", + "output": "something described as a clinical finding about one or more characteristics of soft tissue sarcoma of the retroperitoneum, following the rules of the TNM AJCC v8 classification system." + }, + { + "input": "Concept: post-embryonic root morphogenesis (post-embryonic plant organ morphogenesis)", + "output": "root morphogenesis described as the process in which the anatomical structures of the post-embryonic root are generated and organized. The post-embryonic root is the root formed after the embryonic phase has been completed." + }, + { + "input": "Concept: Acids, Heptanoic (Organic Chemical)", + "output": "Fatty Acids described as 7-carbon saturated monocarboxylic acids." + }, + { + "input": "Concept: What was the severity of your dry skin at its worst (Clinical or Research Assessment Question)", + "output": "something described as a question about an individual's observation of the worst severity they have experienced related to dry skin over the past seven days." + }, + { + "input": "Concept: FAC10007 (Intellectual Product)", + "output": "something described as functional Assessment of Chronic Illness Therapy-Dyspnea Scale 33 Item Bank (FACIT-Dyspnea Scale 33 Item Bank Version) Dyspnea Severity: Over the past 7 days, how short of breath did you get with each of these activities?: Preparing meals." + }, + { + "input": "Concept: Multi-Specific Organic Anion Transporter D (Amino Acid, Peptide, or Protein)", + "output": "Biologically Active Substance described as canalicular multispecific organic anion transporter 2 (1527 aa, ~169 kDa) is encoded by the human ABCC3 gene. This protein is involved in both the transport and metabolism of bile." + }, + { + "input": "Concept: Duchenne's Muscular Dystrophy (Genetic Diseases, X-Linked)", + "output": "Myopathy described as an X-linked inherited disorder caused by mutations in the DMD gene found on the X chromosome. It is characterized by rapidly progressing muscle weakness and muscle atrophy initially involving the lower extremities and eventually affecting the whole body. It affects males whereas females can be carriers. The symptoms start before the age of six and may appear at infancy." + }, + { + "input": "Concept: forkhead box G1 (Gene or Genome)", + "output": "Transcription factor genes described as this gene is involved in transcriptional repression and may play a role in the development of the brain and telencephalon." + }, + { + "input": "Concept: Synthetic Human Papillomavirus 16 E6 Peptide (Amino Acid, Peptide, or Protein)", + "output": "Vaccine Antigen described as a synthetic peptide sequence of human papillomavirus (HPV) type 16 oncoprotein E6. The E6 oncoprotein is implicated in the tumorigenesis of cervical carcinoma. Vaccination with HPV 16 E6 peptide may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against cells expressing the E6 oncoprotein, resulting in tumor cell lysis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C38726\" active clinical trials using this agent." + }, + { + "input": "Concept: FACT-P Version 4 - Satisfied With How I Am Coping (Intellectual Product)", + "output": "FACT-P Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Prostate Version 4 - Emotional Well-Being: I am satisfied with how I am coping with my illness." + }, + { + "input": "Concept: Deacetylases, NAD-Dependent Histone (Histone Deacetylase)", + "output": "Amino Acid, Peptide, or Protein described as a subclass of histone deacetylases that are NAD-dependent. Several members of the SIRTUINS family are included in this subclass." + }, + { + "input": "Concept: hsa-mir-195 (Gene or Genome)", + "output": "Gene or Genome described as human MIR195 wild-type allele is located in the vicinity of 17p13.1 and is 86 bases in length. This allele, which encodes the MIR195 pre-miRNA, plays a role in the regulation of gene expression. Alteration in the expression of this gene is associated with the development of cardiac hypertrophy." + }, + { + "input": "Concept: BF-200 (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as a topical nanoemulsion-based gel formulation containing 5-aminolevulinic acid (ALA), a metabolic precursor of the photosensitizer protoporphyrin IX, with a potential application for enhanced photodynamic therapy (PDT) for various precancerous and malignant skin lesions. After topical administration of a thick layer of the ALA-based BF-200 gel formulation to the affected area, ALA penetrates the skin and is intracellularly converted to protoporphyrin IX (PpIX). Exposure of PpIX to the proper excitation wavelength of light generates singlet oxygen molecules, resulting in a local cytotoxic effect." + }, + { + "input": "Concept: regulation of pulmonary blood pressure (Organism Function)", + "output": "blood pressure regulation described as the process that modulates the force with which blood travels through the lungs. The process is controlled by a balance of processes that increase pressure and decrease pressure." + }, + { + "input": "Concept: Confusion, CTCAE 5.0 (Finding)", + "output": "Psychiatric Disorders, CTCAE described as a disorder characterized by a lack of clear and orderly thought and behavior." + }, + { + "input": "Concept: B(p51B) Gene Rearrangement (Rearrangement of 3q)", + "output": "Cell or Molecular Dysfunction described as a molecular abnormality indicating rearrangement of the TP63 gene." + }, + { + "input": "Concept: tRNA m(1)G(9)-methyltransferase activity (Molecular Function)", + "output": "something described as catalysis of the reaction: S-adenosyl-L-methionine + guanine(9) in tRNA = N(1)-methylguanine(9) in tRNA + S-adenosyl-L-homocysteine." + }, + { + "input": "Concept: 4-(N,N-Dipropylsulfamoyl)benzoes\u00e4ure (Uricosuric Agents)", + "output": "something described as a benzoic acid derivative with antihyperuricemic property. Probenecid competitively inhibits the active reabsorption of urate at the proximal tubule in the kidney thereby increasing urinary excretion of uric acid and lowering serum urate concentrations. This prevents urate deposition and promotes resolution of existing urate deposits. In addition, probenecid modulates the transport of organic acids and acidic drugs at the proximal and distal renal tubule, thereby increasing the drug serum concentration. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C772\" active clinical trials using this agent." + }, + { + "input": "Concept: System, Ecologic (Ecology)", + "output": "something described as a functional system which includes the organisms of a natural community together with their environment." + }, + { + "input": "Concept: Security Digital Card Copiers (Manufactured Object)", + "output": "Manufactured Object described as digital data copiers designed to make copies of digital memory cards used in portable devices. These copiers can usually make copies of standard, high-capacity, and extended high-capacity cards in standard, mini, or micro size. These copiers usually consist of a high-speed automated portable electromechanical unit including electronic circuits, mechanisms, controls, batteries, and appropriate media holding slots; they can make one or more copies from a master card to several single cards. The copiers may work simultaneously with drives that have different interfaces, such as universal serial bus (USB) and parallel and serial attachments (i.e., PATA and SATA respectively) that permit the attachment of the copier to host personal computers to increase the copier capabilities." + }, + { + "input": "Concept: REGRPID (Intellectual Product)", + "output": "Group ID described as a character or string that represents a respiratory system findings group." + }, + { + "input": "Concept: VALG01TN (Intellectual Product)", + "output": "CDISC Clinical Classification Terminology described as test names of clinical classification questions associated with the Veterans Administration Lung Study Group (VALG) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: Prioress (Professional or Occupational Group)", + "output": "something described as a woman who is head of a house of certain orders of nuns, and who is next in rank below an abbess." + }, + { + "input": "Concept: WRAP, STERILIZATION (Medical Device)", + "output": "something described as a sterilization wrap (pack, sterilization wrapper, bag, or accessories, is a device intended to be used to enclose another medical device that is to be sterilized by a health care provider. It is intended to allow sterilization of the enclosed medical device and also to maintain sterility of the enclosed device until used." + }, + { + "input": "Concept: regulation of iron ion import across plasma membrane (regulation of cellular localization)", + "output": "Cell Function described as any process that modulates the frequency, rate or extent of iron ions import across plasma membrane." + }, + { + "input": "Concept: OLIGODENDROGLIOMA, MALIGNANT (Experimental Organism Neoplasm)", + "output": "Experimental Organism Neoplasm described as a malignant neoplasm of the central nervous system arising from oligodendrocytes." + }, + { + "input": "Concept: Herpes simplex infection (SKIN INFECTION/INFLAMMATION)", + "output": "Disorder by body site described as infection caused by the herpes simplex virus; affects the skin and nervous system; produces small temporary (but sometimes painful) blisters on the skin and mucous membranes." + }, + { + "input": "Concept: Refuse (Not to be done)", + "output": "Not to be done described as to decline to do, accept, give, or allow something." + }, + { + "input": "Concept: Fms-Related Tyrosine Kinase 3 Tyr599Cys (FLT3 Protein Variant)", + "output": "something described as a change in the amino acid residue at position 599 in the receptor-type tyrosine-protein kinase FLT3 protein where tyrosine has been replaced by cysteine." + }, + { + "input": "Concept: Epworth Sleepiness Scale Questionnaire (Assessment scales)", + "output": "Intellectual Product described as epworth Sleepiness Scale (ESS) (copyright Murray W. Johns, 1990-1997. All rights reserved.)." + }, + { + "input": "Concept: Epithelium Part (Tissue Part)", + "output": "something described as any component of the avascular cellular layers that cover body surfaces and cavities and may form glands." + }, + { + "input": "Concept: Connective Tissue (soft tissue)", + "output": "Body tissue described as tissue that supports and binds other tissues; consists of connective tissue cells embedded in a large amount of extracellular matrix." + }, + { + "input": "Concept: Urethrometers (Electromechanical Devices)", + "output": "Electromechanical Devices described as a urethral dilator is a device that consists of a slender hollow or solid instrument made of metal, plastic, or other suitable material in a cylindrical form and in a range of sizes and flexibilities. The device may include a mechanism to expand the portion of the device in the urethra and indicate the degree of expansion on a dial. It is used to dilate the urethra. This generic type of device includes the mechanical urethral dilator, urological bougies, metal or plastic urethral sound, urethrometer, filiform, and filiform follower." + }, + { + "input": "Concept: calochortus albus/white fair (Flower Essences)", + "output": "Pharmacologic Substance described as white fairy lantern." + }, + { + "input": "Concept: Chromosome 3 Open Reading Frame 27 Gene (Gene or Genome)", + "output": "Gene or Genome described as human LINC01565 wild-type allele is located within 3q21.3 and is approximately 4 kb in length. This allele, which encodes protein GR6 and long intergenic non-protein coding RNA 1565, is putatively involved in the suppression of cell growth. LINC01565 gene dysfunction is associated with several types of cancer including acute myeloid monocytic leukemia and colorectal cancer." + }, + { + "input": "Concept: Crumpled ear (Abnormality of the pinna)", + "output": "Finding described as distortion of the course of the normal folds of the ear and the appearance of supernumerary crura and folds." + }, + { + "input": "Concept: Taxane Analogue TPI 287 (Pharmacologic Substance)", + "output": "Organic Chemical described as a synthetic, third generation taxane with potential antineoplastic activity. TPI 287 binds to tubulin and stabilizes microtubules, resulting in inhibition of microtubule assembly/disassembly dynamics, cell cycle arrest at the G2/M phase, and apoptosis." + }, + { + "input": "Concept: EXPLORATORY OUTCOME MEASURE (Component of Study Protocol)", + "output": "Qualitative Concept described as exploratory measures that are used to evaluate and/or form hypotheses about the intervention outcome(s)." + }, + { + "input": "Concept: glioblast division (Cell division)", + "output": "Cell Function described as the process resulting in the physical partitioning and separation of a glioblast into daughter cells." + }, + { + "input": "Concept: Prostheses, Elbow, Semi-Constrained, Cemented (Medical Device)", + "output": "Medical Device described as an elbow joint metal/polymer semi-constrained cemented prosthesis is a device intended to be implanted to replace an elbow joint. The device limits translation and rotation in one or more planes via the geometry of its articulating surfaces. It has no linkage across-the-joint. This generic type of device includes prostheses that consist of a humeral resurfacing component made of alloys, such as cobalt-chromium-molybdenum, and a radial resurfacing component made of ultra-high molecular weight polyethylene. This generic type of device is limited to those prostheses intended for use with bone cement (Sec. 888.3027)." + }, + { + "input": "Concept: Lung wedge resection (Pulmonary Surgical Procedures)", + "output": "Lung excision described as surgical removal of a wedge-shaped section of lung." + }, + { + "input": "Concept: umol/l/(mg/kg) (Quantitative Concept)", + "output": "Unit of concentration described as micromoles per liter (concentration), divided by milligrams per kilogram (dose normalized by body weight) or nanomoles per liter (concentration), divided by micrograms per kilogram (dose normalized by body weight)." + }, + { + "input": "Concept: DA-EPOCH-R/HD-M (Regimen Used to Treat Non-Hodgkin Lymphoma)", + "output": "something described as a chemoimmunotherapy regimen consisting of rituximab, etoposide, prednisone, vincristine, cyclophosphamide and doxorubicin (R-EPOCH) in a dose-adjusted (DA) version with high dose methotrexate that can be used for the treatment of non-Hodgkin lymphoma (NHL)." + }, + { + "input": "Concept: mannosamine catabolic process (Molecular Function)", + "output": "mannosamine metabolic process described as the chemical reactions and pathways resulting in the breakdown of mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins." + }, + { + "input": "Concept: Ovarian, Fallopian Tube, and Primary Peritoneal Carcinoma pN1a TNM Finding v8 (Finding)", + "output": "something described as ovarian, fallopian tube, or primary peritoneal carcinoma with metastasis up to 10 mm in greatest dimension." + }, + { + "input": "Concept: Pseudo-Eosinophils to Leukocyte Ratio Measurement (Laboratory Procedure)", + "output": "Laboratory Procedure described as a relative measurement (ratio or percentage) of the pseudo-eosinophils to the leukocytes in a biological sample. The measurement may be expressed as either a ratio or a percentage." + }, + { + "input": "Concept: positive regulation of RhoGEF (positive regulation of guanyl-nucleotide exchange factor activity)", + "output": "Molecular Function described as any process that activates or increases the frequency, rate or extent of Rho guanyl-nucleotide exchange factor activity." + }, + { + "input": "Concept: TDI01-Transition Focal Score (TDI Clinical Classification Question)", + "output": "something described as transition Dyspnea Index (TDI) Transition focal score." + }, + { + "input": "Concept: Activating Transcription Factor 6 (Biologically Active Substance)", + "output": "Activating Transcription Factors described as one of the BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS that is synthesized as a membrane-bound protein in the ENDOPLASMIC RETICULUM. In response to endoplasmic reticulum stress it translocates to the GOLGI APPARATUS. It is activated by PROTEASES and then moves to the CELL NUCLEUS to regulate GENETIC TRANSCRIPTION of GENES involved in the unfolded protein response." + }, + { + "input": "Concept: toxin-antitoxin complex (transcription repressor complex)", + "output": "something described as a bacterial protein complex that neutralises its own toxin by complexing the toxin with the antitoxin. The antitoxin can be either a protein or an RNA. The neutralising toxin-antitoxin complex also acts as a transcriptional repressor of the toxin-antitoxin operon." + }, + { + "input": "Concept: T Cell Specific Surface Glycoprotein CD28 (Costimulatory and Inhibitory T-Cell Receptors)", + "output": "CD Antigens described as t lymphocyte surface molecule; involved in T cell activation and IL2 production." + }, + { + "input": "Concept: Refractory Anaplastic Astrocytoma (Neoplastic Process)", + "output": "Anaplastic astrocytoma described as an anaplastic astrocytoma that is resistant to treatment." + }, + { + "input": "Concept: play (Theatre)", + "output": "Theatre described as a composition in prose or verse presenting in dialogue or pantomime a story involving various characters, usually intended to be acted on a stage and to be regarded as a form of entertainment." + }, + { + "input": "Concept: Skeleton, appendicular (Skeletal System Part)", + "output": "Skeleton described as subdivision of skeleton which consists of the bones of the upper and lower limbs." + }, + { + "input": "Concept: Hemorrhage;epidural (Meningeal disorder)", + "output": "Space-occupying lesion of nervous system described as intracranial hemorrhage into the epidural space." + }, + { + "input": "Concept: Skin Markers (Radiotherapy planning markers)", + "output": "Body reference point marker described as devices intended to be used to write on the patient's skin, e.g., to outline surgical incision sites or mark anatomical sites for accurate blood pressure measurement." + }, + { + "input": "Concept: Arsenate Reductase (Enzyme)", + "output": "Amino Acid, Peptide, or Protein described as a arsenate reductase that can use azurin as a donor-acceptor. It can use a c-type cytochrome or O(2) as donor-acceptor." + }, + { + "input": "Concept: Allopathic & Osteopathic Physicians; Allergy & Immunology (Physicians; Physician/Osteopath)", + "output": "Physicians; Physician/Osteopath described as an allergist-immunologist is trained in evaluation, physical and laboratory diagnosis, and management of disorders involving the immune system. Selected examples of such conditions include asthma, anaphylaxis, rhinitis, eczema, and adverse reactions to drugs, foods, and insect stings as well as immune deficiency diseases (both acquired and congenital), defects in host defense, and problems related to autoimmune disease, organ transplantation, or malignancies of the immune system." + }, + { + "input": "Concept: 5: 126140732-126200608 (Chromosome 5 Physical Location)", + "output": "Spatial Concept described as physical location of LMNB1_Gene" + }, + { + "input": "Concept: L-galactono-gamma-lactone:ferricytochrome-c oxidoreductase activity (Molecular Function)", + "output": "oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor described as catalysis of the reaction: L-galactono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c." + }, + { + "input": "Concept: Interleukin 10 (Laboratory Procedure)", + "output": "Cytokine Measurement described as a measurement of the interleukin 10 in a biological specimen." + }, + { + "input": "Concept: MELANOCORTIN 4 RECEPTOR DEFICIENCY (Melanocortin Pathway Defect)", + "output": "Melanocortin Pathway Defect described as deficiency or dysfunction of the melanocortin 4 receptor, associated with loss-of-function mutation(s) in the MCR4 gene." + }, + { + "input": "Concept: conditioning operant (Conditioning)", + "output": "Psychiatric therapeutic procedure described as learning to anticipate future events on the basis of past experience with the consequences of one's own behavior." + }, + { + "input": "Concept: Clostridiales XI (Firmicutes)", + "output": "something described as a bacterial family of uncertain placement in the phylum Firmicutes and the order Clostridiales that is used to classify the genera Tissierella, Finegoldia and Anaerococcus, among others." + }, + { + "input": "Concept: EGFL6 gene (Gene or Genome)", + "output": "Growth Factor Gene described as this gene plays a role in cell cycle and may play a role in cell growth." + }, + { + "input": "Concept: Prostheses, Dental, Fixed, Complete (Medical Device)", + "output": "Prostheses, Dental, Fixed described as dental prostheses designed for total replacement (i.e., restoration) of the teeth of the upper (i.e., maxilla) or lower (i.e., mandible) jaw. The prostheses are fixed (e.g., cemented) in place by the dentist, and the user cannot remove them. Complete dental prostheses are typically custom-made devices that include two main components: the retainers (i.e., castings), joined by connectors, and pontics (artificial teeth that are integral components of the prostheses); they are made of cast metal alloys, or combinations of metal alloys and synthetic (e.g., acrylic) resins or ceramic. Complete fixed dental prostheses are intended to totally replace the missing teeth in edentulous patients." + }, + { + "input": "Concept: Comparative Biochemistry (Biomedical Occupation or Discipline)", + "output": "something described as the study of the similarities and differences between different living organisms of the biological and physiological chemistry of the organisms. Used for the scientific discipline or the biochemical processes themselves." + }, + { + "input": "Concept: Thiocapsa Winogradsky 1888 (Approved Lists 1980) emend. Guyoneaud et al. 1998 (Chromatiaceae)", + "output": "something described as a genus of anoxygenic, photosynthetic, nonmotile, spherical to slightly ovoid bacterial cells occurring singly, or in aggregates of two or four, and usually surrounded with slime. It is found in stagnant water, mud of ponds, estuaries, and microbial mats of salt marshes." + }, + { + "input": "Concept: Curved outermost ring finger bone (Curved distal phalanges of the hand)", + "output": "something described as curved appearance of the distal phalanx of the 4th (ring) finger." + }, + { + "input": "Concept: S. aureus, Methicillin-resistant (Microbiology procedure)", + "output": "Laboratory or Test Result described as the determination of the amount of methicillin-resistant Staphylococcus aureus present in a sample." + }, + { + "input": "Concept: rooting reflex (Infant milestone: 1 month)", + "output": "Infant milestone: 1 month described as an involuntary response in the neonate to search for the nipple when the cheek is touched, that disappears by 3-4 months of age." + }, + { + "input": "Concept: AC (Gene or Genome)", + "output": "Hydrolase Gene described as this gene plays a role in sphingolipid metabolism." + }, + { + "input": "Concept: galacturonate metabolism (Molecular Function)", + "output": "Molecular Function described as the chemical reactions and pathways involving galacturonate, the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." + }, + { + "input": "Concept: Leptomyelolipoma (Congenital anomaly of back)", + "output": "Congenital anomaly of back described as a rare neural tube closure defect characterised by an abnormally low lying conus which is tethered by a lumbosacral lipomatous mass (containing fatty tissue, nerve fibres, meningeal strands and fibrous bands) which engulfs the filum terminale and varying numbers of dorsal and ventral nerve root components, typically producing sensory, motor, bowel and/or bladder dysfunction. Cutaneous stigmata, absent or reduced reflexes and foot deformities (for example talipes cavovalgus) are frequently present." + }, + { + "input": "Concept: FAS (Gene or Genome)", + "output": "FASN gene described as human FASN wild-type allele is located within 17q25 and is approximately 20 kb in length. This allele, which encodes fatty acid synthase protein, is involved in the biosynthesis of long-chain fatty acids. The FASN gene is overexpressed in many epithelial cancers and is associated with poor prognosis." + }, + { + "input": "Concept: Syndrome, Mallory-Weiss (Syndrome)", + "output": "Gastric hemorrhage described as a condition characterized by mucosal tears at the ESOPHAGOGASTRIC JUNCTION, sometimes with HEMATEMESIS. Typically it is caused by forceful bouts of retching or VOMITING." + }, + { + "input": "Concept: SPRY4IT1 (SPRY4-IT1 gene)", + "output": "SPRY4-IT1 gene described as human SPRY4-IT1 wild-type allele is located in the vicinity of 5q31.3 and is approximately 700 bp in length. This allele, which encodes SPRY4 intronic transcript 1 (non-protein coding) RNA, may be involved in melanoma cell proliferation and survival." + }, + { + "input": "Concept: Peak Concentration (Pharmaceutical Product Characteristics)", + "output": "Quantitative Concept described as used in pharmacokinetics and bioequivalence to indicate maximum plasma concentration for a drug." + }, + { + "input": "Concept: Nipah-virus (Henipavirus)", + "output": "Paramyxovirus, NOS described as species of Henipavirus, closely related to Hendra virus, which emerged in Peninsular Malaysia in 1998; it causes a severe febrile encephalitis in humans and also encephalitis and respiratory tract diseases in pigs; fruit bats are the natural host." + }, + { + "input": "Concept: Health Knowledge & Behavior (Intellectual Product)", + "output": "something described as outcomes that describe attitudes, comprehension, and actions with respect to health and illness" + }, + { + "input": "Concept: ACH (SPECIFIC SUBSTANCE CHEMISTRY TESTS)", + "output": "Hormone measurement described as a measurement of the acetylcholine hormone in a biological specimen." + }, + { + "input": "Concept: Severe Pain or Discomfort that Prevented Most Activities (Clinical or Research Assessment Answer)", + "output": "something described as a response indicating that an individual has or had severe pain or discomfort that prevented most activities." + }, + { + "input": "Concept: menthol biosynthetic process (secondary alcohol biosynthetic process)", + "output": "secondary alcohol biosynthetic process described as the chemical reactions and pathways resulting in the formation of menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol." + }, + { + "input": "Concept: IV peripheral route (Drug Administration Routes)", + "output": "Functional Concept described as an intravenous route that begins in a peripheral vein." + }, + { + "input": "Concept: collagen type XXVII trimer (fibrillar collagen location)", + "output": "something described as a collagen homotrimer of alpha1(XXVII) chains. These trimers form thin, non-striated fibrils. Type XXVII collagen triple helices play a role during the calcification of cartilage and the transition of cartilage to bone." + }, + { + "input": "Concept: Automation Systems, Medication Dispensing (Automation Systems)", + "output": "something described as automation systems designed for use in healthcare facilities to dispense medications. They can usually read patient's medication orders and retrieve the correct medication, adjusting the inventory and/or the patient's bill. Most systems can accommodate oral medicines (solid or liquid), ophthalmic drops, prefilled syringes, and topical preparations. They are usually interfaced with the pharmacy and/or the hospital information systems. Medication-dispensing automation systems are available either for a centralized distribution of medicines only in a central clinical pharmacy or throughout the hospital through computerized cabinets in patient care areas and/or nurse stations. All these systems are intended to improve the safety and/or efficiency of dispensing medications; they are usually configured according to particular hospital pharmacy requirements." + }, + { + "input": "Concept: Lean spastic dwarfism (Disease or Syndrome)", + "output": "Disease or Syndrome described as a syndrome of spastic dwarfism with prominent eyes associated with retarded bone age, delayed mental development, small size at birth and during early childhood, slender build, spasticity, convulsions, and characteristic facies." + }, + { + "input": "Concept: Inferior surface of neck of scapula (Surface of region of neck of scapula)", + "output": "something described as surface of region of neck of scapula bounding infraglenoid tubercle." + }, + { + "input": "Concept: Contiguous Stage II Grade II Follicular Mixed Cell Lymphoma (Ann Arbor Stage II Grade 2 Follicular Lymphoma)", + "output": "Neoplastic Process described as ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE)." + }, + { + "input": "Concept: Nursing homes (Health System)", + "output": "Elderly described as facilities which provide nursing supervision and limited medical care to persons who do not require hospitalization." + }, + { + "input": "Concept: Blood Loss (Fluid and Electrolyte Manifestation)", + "output": "something described as loss of blood from the circulation, either internally or externally." + }, + { + "input": "Concept: entorhinal cortex, medial part (Body Part, Organ, or Organ Component)", + "output": "Body Part, Organ, or Organ Component described as one of two subdivisions of the entorhinal area in the mouse; the other is the lateral entorhinal cortex ( Hof-2000 )." + }, + { + "input": "Concept: Primary Care Evaluation of Mental Disorders Patient Health Questionnaire (Intellectual Product)", + "output": "Intellectual Product described as a self-administered diagnostic instrument developed for use in Primary Care settings to screen for common mental disorders, including alcohol abuse and dependence." + }, + { + "input": "Concept: FAC10031 (Intellectual Product)", + "output": "Intellectual Product described as functional Assessment of Chronic Illness Therapy-Dyspnea Scale 33 Item Bank - Dyspnea Severity: Over the past 7 days, how short of breath did you get with each of these activities?: Walking 1/2 mile (almost 1 km) on flat ground at a normal speed without stopping." + }, + { + "input": "Concept: Procedure May Have Partially Excised Anatomy (NCI Thesaurus Role)", + "output": "something described as a role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure sometimes results in partial excision of the specified anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs, and where partial excision is explicit or can be inferred (e.g. biopsy). The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively." + }, + { + "input": "Concept: HbH haemoglobin (Hemoglobinopathies)", + "output": "Hemoglobin described as hemoglobin H (HbH) contains four beta-globin chains. It is normally not present at all in blood, but may make up about 1-40 percent of all hemoglobin in HbH disease, a subform of alpha thalassemia." + }, + { + "input": "Concept: fracture orbit (Injury or Poisoning)", + "output": "Injury of eye region described as fractures of the bones in the orbit, which include parts of the frontal, ethmoidal, lacrimal, and sphenoid bones and the maxilla and zygoma." + }, + { + "input": "Concept: alcoholism/alcohol abuse information system (Intellectual Product)", + "output": "Intellectual Product described as integrated set of files, procedures, and equipment for the storage, manipulation, and retrieval of information on alcohol, alcoholism, alcohol abuse and may include therapies, treatments, education, etc.; also used to cover the concept of alcoholism or alcohol abuse databases." + }, + { + "input": "Concept: Were Other Preoperative IV Medications Administered (CPTAC Questions)", + "output": "Intellectual Product described as a question about whether other preoperative intravenous medications were administered." + }, + { + "input": "Concept: Sodium salicylate product (Anti-Inflammatory Agents, Non-Steroidal)", + "output": "Pharmacologic Substance described as a drug that is a type of nonsteroidal anti-inflammatory drug. Sodium salicylate may be tolerated by people who are sensitive to aspirin." + }, + { + "input": "Concept: oxaliplatino (Platinum Compounds)", + "output": "Platinum-based Drug [EPC] described as a drug used with other drugs to treat colorectal cancer that is advanced or has come back. It is also being studied in the treatment of other types of cancer. Eloxatin attaches to DNA in cells and may kill cancer cells. It is a type of platinum compound." + }, + { + "input": "Concept: 8B5-8C3 SUBORDER RUMINANTIA - CUD-CHEWERS (Eutheria)", + "output": "Mammal described as a suborder of the order ARTIODACTYLA whose members have the distinguishing feature of a four-chambered stomach, including the capacious RUMEN. Horns or antlers are usually present, at least in males." + }, + { + "input": "Concept: Parathyroid hormone (Hormone)", + "output": "Endocrine system described as a polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates." + }, + { + "input": "Concept: Dependency, Psychological (Personality Traits)", + "output": "Property or Attribute described as tendency of an individual or individuals to rely on others for advice, guidance, or support." + }, + { + "input": "Concept: Talabostat Mesylate (Amino Acid, Peptide, or Protein)", + "output": "Protease Inhibitors described as the mesylate salt of an orally active small molecule with antineoplastic and hematopoiesis- stimulating activities. By cleaving N-terminal Xaa-Pro or Xaa-Ala residues, talabostat inhibits dipeptidyl peptidases, such as fibroblast activation protein (FAP), resulting in the stimulation of cytokine and chemokine production and specific T-cell immunity and T-cell dependent activity. This agent may also stimulate the production of colony stimulating factors, such as granulocyte colony stimulating factor (G-CSF), resulting in the stimulation of hematopoiesis. Dipeptidyl peptidases are involved in the activation of polypeptide hormones and chemokines. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C80682\" active clinical trials using this agent." + }, + { + "input": "Concept: Grade 4 Anaphylaxis, CTCAE (Anaphylaxis, CTCAE)", + "output": "something described as life-threatening consequences; urgent intervention indicated" + }, + { + "input": "Concept: Unspecified Renovascular Hypertension (Disease or Syndrome)", + "output": "Disease or Syndrome described as high blood pressure caused by renal artery stenosis." + }, + { + "input": "Concept: CHD-2 (DNA Helicases)", + "output": "DNA Helicases described as chromodomain-helicase-DNA-binding protein 2 (1828 aa, ~211 kDa) is encoded by the human CHD2 gene. This protein may be involved in chromatin structure modification." + }, + { + "input": "Concept: Urethritides (Inflammation of specific body organs)", + "output": "Inflammatory disorder described as inflammation involving the URETHRA. Similar to CYSTITIS, clinical symptoms range from vague discomfort to painful urination (DYSURIA), urethral discharge, or both." + }, + { + "input": "Concept: nutrition aging (Occupation or Discipline)", + "output": "Occupation or Discipline described as nutrition as a function of age; use for middle through old age and death." + }, + { + "input": "Concept: 14q13.1 (Chromosome band)", + "output": "Chromosome band described as a chromosome band present on 14q" + }, + { + "input": "Concept: Histone 1, H2aa Gene (Gene or Genome)", + "output": "H2AC1 Gene described as human H2AC1 wild-type allele is located in the vicinity of 6p22.2 and is approximately 1 kb in length. This allele, which encodes histone H2A type 1-A protein, plays a role in DNA compaction." + }, + { + "input": "Concept: TSCYC - Calling Himself or Herself Bad (TSCYC Questionnaire Question)", + "output": "TSCYC Questionnaire Question described as trauma Symptom Checklist for Young Children - Please indicate how often the child has done, felt, or experienced each of the following things in the last month: Calling himself or herself bad, stupid, or ugly." + }, + { + "input": "Concept: TCF-12 (Amino Acid, Peptide, or Protein)", + "output": "Biologically Active Substance described as transcription factor 12 (682aa, ~73 kDa) is encoded by the human TCF12 gene. This protein is involved in transcriptional regulation that modulates tissue differentiation." + }, + { + "input": "Concept: Architecture and Engineering (Miscellaneous Occupation)", + "output": "something described as a class of professional or vocational positions of employment that involve architecture or engineering." + }, + { + "input": "Concept: Vesicle, Cytoplasmic (Endoplasm)", + "output": "intracellular vesicle described as a vesicle found in the cytoplasm of a cell." + }, + { + "input": "Concept: Halobetasol propionate preparation (Organic Chemical)", + "output": "something described as the propionate salt form of halobetasol, a synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictor activities. Halobetasol, a topical steroid, diffuses across cell membranes to interact with cytoplasmic corticosteroid receptors located in both the dermal and intradermal cells, thereby activating gene expression of anti-inflammatory proteins mediated via corticosteroid receptor response element. Specifically, this agent induces phospholipase A2 inhibitory proteins, which inhibit the release of arachidonic acid, thereby inhibiting the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes. As a result, halobetasol reduces edema, erythema, and pruritus through its cutaneous effects on vascular dilation and permeability." + }, + { + "input": "Concept: Pim kinase inhibitor SGI-1776 (Serine/Threonine Kinase Inhibitor)", + "output": "Antineoplastic Enzyme Inhibitor described as a small-molecule pan-PIM protein kinase inhibitor with potential antineoplastic activity. PIM kinase inhibitor SGI-1776 binds to and inhibits the activities of PIM-1, -2 and -3 serine/threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, the expression of pro-apoptotic Bcl2 proteins and tumor cell apoptosis. PIM kinases play key roles in cell cycle progression and apoptosis inhibition and may be overexpressed in various malignancies." + }, + { + "input": "Concept: negative regulation by symbiont of host neurotransmitter secretion (Organism Function)", + "output": "modulation by symbiont of host neurotransmitter secretion described as any process in which a symbiont organism negatively regulates the regulated release of a neurotransmitter from a cell in its host organism." + }, + { + "input": "Concept: Posterior retinal neovascularization (Anatomical Abnormality)", + "output": "Retinal Neovascularization described as a type of retinal neovascularization that affects the posterior pole of the retina." + }, + { + "input": "Concept: Recurrent enteroviral infections (Finding)", + "output": "Finding described as increased susceptibility to enteroviral infections, as manifested by recurrent episodes of enteroviral infection." + }, + { + "input": "Concept: PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Young Child - Hands Are Weak (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Young Child Questionnaire Question)", + "output": "PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Young Child Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Acute Version 3.0 Parent Report for Young Child (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Young Child) In the past 7 days, how much of a problem has this been for your child: My child's hands are weak." + }, + { + "input": "Concept: NEISSERIA MUCOSA (Bacterium)", + "output": "something described as any bacterial organism that can be assigned to the species Neisseria mucosa." + }, + { + "input": "Concept: BPI122L (Intellectual Product)", + "output": "Intellectual Product described as brief Pain Inventory - Check Yes or No if the adjective applies to your pain: nagging." + }, + { + "input": "Concept: Plasmodium chabaudi (Plasmodium )", + "output": "Plasmodium described as a protozoan parasite of rodents transmitted by the mosquito Anopheles stephensi." + }, + { + "input": "Concept: Shave Excision (Surgical Procedure by Method)", + "output": "Excision described as a surgical procedure where thin slices are remove with or as if with a plane." + }, + { + "input": "Concept: 10*3.{DNA copies}/ml (cpy/mL)", + "output": "something described as a unit of measurement equal to 10 to the third power of the number of deoxyribonucleic acid (DNA) copies per unit of volume equal to one milliliter." + }, + { + "input": "Concept: Unexpected Adverse Event (Finding)", + "output": "Adverse Event by Type described as an adverse reaction, whose nature, severity, specificity, or outcome is not consistent with the term or description used in the applicable product information. [ICH E2] See also adverse drug reaction." + }, + { + "input": "Concept: Nucleolonema (Cardinal cell part)", + "output": "Subcellular structure described as the irregular network or rows of fine ribonucleoprotein granules or microfilaments forming most of the nucleolus." + }, + { + "input": "Concept: penis structure (Structure of fetal genitourinary system)", + "output": "Body Part, Organ, or Organ Component described as an external male reproductive organ. It contains a tube called the urethra, which carries semen and urine to the outside of the body." + }, + { + "input": "Concept: L-alanine:proton antiporter activity (L-alanine transmembrane transporter activity)", + "output": "something described as enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + L-alanine(in) = H+(in) + L-alanine(out)." + }, + { + "input": "Concept: Withdrawal Syndromes, Substance (Substance related and addictive disorders)", + "output": "Multiple Organ Syndromes NEC described as a substance-specific organic brain syndrome that follows the discontinuation of administration or use, or reduction in intake of an addictive substance, e.g. opioids, barbiturates and alcohol; amphetamines or similarly acting sympathomimetics; cocaine; nicotine; sedatives, hypnotics, or anxiolytics. Syndrome manifests with diverse, often painful physical and psychological symptoms, which include but not limited to intense drug craving, anxiety, depression, insomnia, nausea, perspiration, body aches, tremors, hallucinations, and convulsions." + }, + { + "input": "Concept: Grade 1 Infantile Vomiting (Infantile Vomiting, Adverse Event)", + "output": "Finding described as an adverse event in a newborn characterized by an increase in vomiting over baseline, self limiting." + }, + { + "input": "Concept: Sertoli cell apoptotic process (Cell Function)", + "output": "Cell Function described as any apoptotic process in a Sertoli cell." + }, + { + "input": "Concept: Electrode Contact (Manufactured Object)", + "output": "Manufactured Object described as a connector on a device designed to couple with an electrode." + }, + { + "input": "Concept: ADENOMA, RETE TESTIS, BENIGN (Rete Testis Neoplasm)", + "output": "Neoplastic Process described as a benign epithelial neoplasm arising from the rete testis." + }, + { + "input": "Concept: Beers (Alcoholic Beverages)", + "output": "Food described as an alcoholic beverage usually made from malted cereal grain (as barley), flavored with hops, and brewed by slow fermentation." + }, + { + "input": "Concept: BiologicEntity.birthOrder (Qualitative Concept)", + "output": "something described as indicates the sequence of a biologic entity's birth in the family group." + }, + { + "input": "Concept: Autoimmune Hepatitides (Disease or Syndrome)", + "output": "Autoimmune hepatitis described as a chronic self-perpetuating hepatocellular INFLAMMATION of unknown cause, usually with HYPERGAMMAGLOBULINEMIA and serum AUTOANTIBODIES." + }, + { + "input": "Concept: PGY3 (ABCB4 gene)", + "output": "something described as human ABCB4 wild-type allele is located in the vicinity of 7q21.1 and is approximately 79 kb in length. This allele, which encodes multidrug resistance protein 3, plays a role in the intramembrane transport of phosphatidylcholine and the export of organic anions and drugs across the plasma membrane. Mutation of the gene is associated with progressive familial intrahepatic cholestasis 2, intrahepatic cholestasis of pregnancy 3 and gall bladder disease 3." + }, + { + "input": "Concept: Anti-CD4 Monoclonal Antibody (Immunologic Factor)", + "output": "Monoclonal Antibodies described as any monoclonal antibody directed against the cell surface glycoprotein CD4, regardless of the antibody type." + }, + { + "input": "Concept: Stage II Thyroid Gland Follicular Carcinoma AJCC v8 (Stage II Differentiated Thyroid Gland Carcinoma AJCC v8)", + "output": "Neoplastic Process described as stage II includes: Under 55 years: Any T, Any N, M1; 55 years and older: (T1, N1, M0); (T2, N1, M0); (T3a/T3b, Any N, M0). T1: Tumor measuring 2 cm or less in greatest dimension limited to the thyroid. T2: Tumor measuring more than 2 cm but 4 cm or less in greatest dimension limited to the thyroid. T3a: Tumor measuring more than 4 cm in greatest dimension limited to the thyroid. T3b: Gross extrathyroidal extension invading only strap muscles (sternohyoid, sternothyroid, thyrohyoid, or omohyoid muscles) from a tumor of any size. N1: Metastasis to regional nodes. M0: No distant metastasis. M1: Distant metastasis." + }, + { + "input": "Concept: Ataxic gait (Peripheral Nervous System)", + "output": "Gait Disorders, Neurologic described as ambulatory abnormalities caused by an impairment of voluntary muscle coordination, most often and significantly affecting gait." + }, + { + "input": "Concept: KIM-3 (Gene or Genome)", + "output": "HAVCR2 gene described as human HAVCR2 wild-type allele is located in the vicinity of 5q33.3 and is approximately 57 kb in length. This allele, which encodes hepatitis A virus cellular receptor 2 protein, is involved in the activation of macrophages and helper T cells." + }, + { + "input": "Concept: Antibodies, Heterologous (Heterophile)", + "output": "Functional Immunologic Units described as antibody produced by the introduction of heterophile antigen into a species which does not carry it." + }, + { + "input": "Concept: DDR1 Protein (discoidin receptor)", + "output": "Receptor described as a discoidin domain receptor for FIBRILLAR COLLAGEN that functions in a variety of cellular processes. For example, it regulates cell attachment to the EXTRACELLULAR MATRIX, remodeling of the extracellular matrix, CELL MIGRATION; CELL DIFFERENTIATION; CELL PROLIFERATION; and CELL SURVIVAL." + }, + { + "input": "Concept: HMG-CoA reductase (Oxidoreductase)", + "output": "Enzyme described as specific hydroxymethylglutaryl CoA reductases that utilize the cofactor NAD. In liver enzymes of this class are involved in cholesterol biosynthesis." + }, + { + "input": "Concept: Rho interacting protein 3, human (Amino Acid, Peptide, or Protein)", + "output": "something described as myosin phosphatase Rho-interacting protein (1025 aa, ~117 kDa) is encoded by the human MPRIP gene. This protein plays a role in the recruitment of myosin phosphatase to the cytoskeleton." + }, + { + "input": "Concept: Folate Hydrolase mRNA Measurement (Laboratory Procedure)", + "output": "something described as the determination of the amount of folate hydrolase mRNA in a biological sample." + }, + { + "input": "Concept: cellular response to oestrogen stimulus (cellular response to chemical stimulus)", + "output": "response to estrogen described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics." + }, + { + "input": "Concept: Bladder anastomotic leak (Injury, Poisoning and Procedural Complications, CTCAE)", + "output": "Injury, Poisoning and Procedural Complications, CTCAE described as a finding of leakage of urine due to breakdown of a bladder anastomosis (surgical connection of two separate anatomic structures)." + }, + { + "input": "Concept: Faces (Face and/or neck structure)", + "output": "Head and neck structure described as the anterior portion of the head extending from the forehead to the chin and ear to ear. The facial structures contain the eyes, nose and mouth, cheeks and jaws." + }, + { + "input": "Concept: microbody lumen (intracellular organelle lumen)", + "output": "Cell Component described as the volume enclosed by the membranes of a microbody." + }, + { + "input": "Concept: Beds, Mechanical, Cradle, Pediatric (Medical Device)", + "output": "Beds, Mechanical described as mechanical beds designed with a configuration resembling a baby cradle, incorporating fixed endrails and movable and latchable siderails and/or a fabric framed canopy. Pediatric cradle mechanical beds restrain children passively, avoiding the risk of patient falls while providing easy access to the patient by the staff." + }, + { + "input": "Concept: Normal Male External Genitalia (Male Reproductive System Finding)", + "output": "Male Reproductive System Finding described as an indication that on visual inspection the male external genitalia demonstrate no anomalies or abnormal findings." + }, + { + "input": "Concept: PROT-Att Physical Address (CDISC Protocol Terminology)", + "output": "something described as terminology associated with the protocol entity physical address attribute codelist of the Clinical Data Interchange Standards Consortium (CDISC)." + }, + { + "input": "Concept: CSS11-Idea, No Intent, No Plan, Describe (Intellectual Product)", + "output": "Intellectual Product described as columbia-Suicide Severity Rating Scale Lifetime/Recent Version - Description of active suicidal ideation with any methods (not plan) without intent to act." + }, + { + "input": "Concept: Recurrent Ovarian Endometrioid Adenocarcinoma (Recurrent Ovarian Adenocarcinoma)", + "output": "Endometrioid carcinoma ovary described as the reemergence of ovarian endometrioid adenocarcinoma after a period of remission." + }, + { + "input": "Concept: respiration regulatory center (Body Location or Region)", + "output": "brain regulatory center described as series of centers in the medulla and pons which coordinate respiratory movements; they include the pneumotaxic center, the apneustic center, and the dorsal and ventral respiratory groups." + }, + { + "input": "Concept: reviewing (Intellectual Product)", + "output": "Journal Article described as an article or book published after examination of published material on a subject. It may be comprehensive to various degrees and the time range of material scrutinized may be broad or narrow, but the reviews most often desired are reviews of the current literature. The textual material examined may be equally broad and can encompass, in medicine specifically, clinical material as well as experimental research or case reports. State-of-the-art reviews tend to address more current matters. A review of the literature must be differentiated from HISTORICAL ARTICLE on the same subject, but a review of historical literature is also within the scope of this publication type." + }, + { + "input": "Concept: Malignant MEST (Malignant Mixed Tumor)", + "output": "Neoplastic Process described as a mixed epithelial stromal tumor of the kidney with malignant stromal features." + }, + { + "input": "Concept: Exocrine Pancreatic Cancer pM1 TNM Finding v8 (Finding)", + "output": "something described as exocrine pancreatic cancer with distant metastasis." + }, + { + "input": "Concept: Tip breakage (Finding)", + "output": "Finding described as the end of a device is fractured or damaged." + }, + { + "input": "Concept: Benzeneacetic acid, alpha-methyl-4-(2-thienylcarbonyl)- (Pharmaceutical Preparations)", + "output": "Organic Chemical described as an IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic." + }, + { + "input": "Concept: Genus Dientamoeba (Family Monocercomonadidae)", + "output": "Subphylum Mastigophora described as a genus of minute EUKARYOTES that are characterized by the preponderance of binucleate over uninucleate forms, the presence of several distinct granules in the karyosome, and the lack of a cystic stage. It is parasitic in the large intestine of humans and certain monkeys." + }, + { + "input": "Concept: RADIOIMMUNOASSAY, IMMUNOGLOBULINS (Indicator, Reagent, or Diagnostic Aid)", + "output": "Indicator, Reagent, or Diagnostic Aid described as an immunoglobulins A, G, M, D, and E immunological test system is a device that consists of the reagents used to measure by immunochemical techniques the immunoglobulins A, G, M, D, an E (serum antibodies) in serum. Measurement of these immunoglobulins aids in the diagnosis of abnormal protein metabolism and the body's lack of ability to resist infectious agents." + }, + { + "input": "Concept: Physical Activity Recording Software (Software, Physiologic Recording)", + "output": "something described as physiologic recording software designed for later processing of physical activity (i.e., movement) data obtained while recording. This software is intended to work only with one or a few models of physical activity recorders, usually from the same manufacturer. The software may perform a variety of algorithms to facilitate the analysis of measurements performed during recording; the software may also be used to send and/or receive patient information from and to hospital information systems. Physical activity recording software is mainly intended for processing the data using a recorded data processor or a standard computer (e.g., a personal computer)." + }, + { + "input": "Concept: Deoxyuracil Nucleotides (Nucleic Acid, Nucleoside, or Nucleotide)", + "output": "Nucleic Acid, Nucleoside, or Nucleotide described as uracil nucleotides which contain deoxyribose as the sugar moiety." + }, + { + "input": "Concept: CCQ02-Breathing Limit Social Activity (CCQ 1 Week Version Questionnaire Question)", + "output": "Intellectual Product described as clinical COPD Questionnaire 1 Week Version - On average, during the past 7 days, how limited were you in these activities because of your breathing problems: Social activities?" + }, + { + "input": "Concept: cut like homeobox 1 (Gene or Genome)", + "output": "something described as this gene is involved in both transcriptional regulation and Golgi vesicle transport." + }, + { + "input": "Concept: Domes, Pressure Transducer (Electromechanical Devices)", + "output": "Medical Device described as dedicated caps or connectors that couple with and fit on pressure transducers which are used to invasively monitor blood pressure or pressures of other liquids or gases. These domes can be various sizes and are usually made of sturdy plastic and feature one or more stopcocks to direct the flow of the liquid or gas onto a diaphragm or membrane whose deformation is sensed by various methods by the pressure transducer. Pressure transducer domes may be sterilizable or disposable." + }, + { + "input": "Concept: external side of apical plasma membrane (external side of plasma membrane)", + "output": "something described as the leaflet the apical region of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." + }, + { + "input": "Concept: CULTURE MEDIA, SELECTIVE AND DIFFERENTIAL (Medical Device)", + "output": "Medical Device described as a selective culture medium is a device that consists primarily of liquid or solid biological materials intended for medical purposes to cultivate and identify certain pathogenic microorganisms. The device contains one or more components that suppress the growth of certain microorganisms while either promoting or not affecting the growth of other microorganisms. The device aids in the diagnosis of disease caused by pathogenic microorganisms and also provides epidemiological information on these diseases." + }, + { + "input": "Concept: c-ABL1 Gene Rearrangement (Gene Rearrangement Abnormality)", + "output": "Cell or Molecular Dysfunction described as a molecular abnormality indicating rearrangement of the ABL1 gene." + }, + { + "input": "Concept: SCC-Sq cell carcin anal margin (Anal margin neoplasm)", + "output": "Malignant tumor of digestive organ described as a squamous cell carcinoma arising from the perianal skin." + }, + { + "input": "Concept: Date Created (Temporal Concept)", + "output": "Temporal Concept described as the date the data creation started." + }, + { + "input": "Concept: anaerobic pectin catabolic process (pectin catabolic process)", + "output": "something described as the chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, in the absence of oxygen." + }, + { + "input": "Concept: Patient Liftings (Health Care Activity)", + "output": "Health Care Activity described as moving or repositioning patients within their beds, from bed to bed, bed to chair, or otherwise from one posture or surface to another." + }, + { + "input": "Concept: b cells lymphoma (B-cell lymphomas NEC)", + "output": "Lymphoid neoplasm described as a type of cancer that forms in B cells (a type of immune system cell). B-cell lymphomas usually occur in adults and may be either indolent (slow-growing) or aggressive (fast-growing). There are many different types of B-cell lymphomas, and prognosis and treatment depend on the type and stage of cancer." + }, + { + "input": "Concept: 2-Propanol, 1-((1-methylethyl)amino)-3-(2-propylphenoxy)- (Pharmacologic Substance)", + "output": "something described as hydrogenated alprenolol derivative where the extra hydrogens are often tritiated. This radiolabeled form of ALPRENOLOL, a beta-adrenergic blocker, is used to label the beta-adrenergic receptor for isolation and study." + }, + { + "input": "Concept: regulation of convergent extension involved in rhombomere morphogenesis (regulation of nervous system development)", + "output": "something described as any process that modulates the frequency, rate or extent of convergent extension involved in rhombomere morphogenesis." + }, + { + "input": "Concept: ROLE RELATIONSHIP COMPONENT (Intervention regimes)", + "output": "patient care data set described as cluster of elements involving interpersonal, work, social, family, and sexual interactions." + }, + { + "input": "Concept: regulation of viral-induced cytoplasmic pattern recognition receptor signalling pathway (regulation of intracellular signal transduction)", + "output": "something described as any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm." + }, + { + "input": "Concept: ANTITHROMBIN 3 DEFIC (Blood Coagulation Disorders, Inherited)", + "output": "ANTICOAGULANT DISORDERS described as an absence or reduced level of Antithrombin III leading to an increased risk for thrombosis." + }, + { + "input": "Concept: Apolipoprotein CI (Protein or Enzyme Type Measurement)", + "output": "Laboratory Procedure described as the determination of the apolipoprotein CI present in a sample." + }, + { + "input": "Concept: Abnormal lacrimal punctum morphology (Anatomical Abnormality)", + "output": "Anatomical Abnormality described as an abnormality of the lacrimal punctum, an opening on the eyelid close to the medial canthus that drains tears from the conjunctival sac into the lacrimal duct in the same eyelid." + }, + { + "input": "Concept: negative regulation of trichoblast fate specification (Cell Function)", + "output": "Cell Function described as any process that suppresses trichoblast fate specification." + }, + { + "input": "Concept: laboratory (Clinical or Research Facility)", + "output": "Health care facility described as an organization with the capability and competency to perform scientific research, experiments and measurements." + }, + { + "input": "Concept: antidiuretic hormone (ADH) test (Hormone measurement)", + "output": "Hormone measurement described as the determination of the amount of antidiuretic hormone present in a sample." + }, + { + "input": "Concept: 1-dehydro-16alpha-methyl-9alpha-fluorohydrocortisone (Steroids, Fluorinated)", + "output": "Corticosteroids/antiinfectives/mydriatics in combination described as a synthetic steroid (similar to steroid hormones produced naturally in the adrenal gland). Dexamethasone is used to treat leukemia and lymphoma and may be used to treat some of the problems caused by other cancers and their treatment." + }, + { + "input": "Concept: Flagellum of spermatozoon (sperm cell)", + "output": "Spermatozoa structure described as the posterior filiform portion of the spermatozoon (SPERMATOZOA) that provides sperm motility." + }, + { + "input": "Concept: Benign Ovarian Cystadenoma (Cystadenoma)", + "output": "Neoplastic Process described as a benign ovarian surface epithelial-stromal tumor characterized by the presence of cystic structures lined by serous epithelial cells, mucinous columnar epithelial cells, or endometrial-type well-differentiated cells." + }, + { + "input": "Concept: Search - action (Activity)", + "output": "Activity described as the activity of looking thoroughly in order to find something or someone; an operation that determines whether one or more of a set of items has a specified property." + }, + { + "input": "Concept: SIC (Classification)", + "output": "Classification described as a code scheme established to promote uniformity and comparability of data collected and published by agencies within the U.S. government, state agencies, trade associations, and research organizations. It was developed as an establishment based industry classification system that classified each establishment (defined as a single physical location at which economic activity occurs) according to its primary activity. The SIC covered the entire field of economic activities by defining industries in accordance with the composition and structure of the economy. It has been replaced by the North American Industry Classification System (NAICS)." + }, + { + "input": "Concept: 16: 13921524-13949705 (Spatial Concept)", + "output": "something described as physical location of ERCC4_Gene" + }, + { + "input": "Concept: Anocithesia (Therapeutic or Preventive Procedure)", + "output": "something described as a historical term for a method of anesthesia that used a combination of preanesthetic medication for sedation, local nerve blocking anesthetic at the surgical site, and NITROUS OXIDE inhalation anesthesia." + }, + { + "input": "Concept: Vitamin K Deficiency Bleeding (Disease or Syndrome)", + "output": "Disease or Syndrome described as hemorrhage caused by vitamin K deficiency." + }, + { + "input": "Concept: heart injuries (Structural disorder of heart)", + "output": "something described as trauma to the cardiac muscle or valves." + }, + { + "input": "Concept: Alpha-Glucosidase Inhibitor (Glucosidase Inhibitor)", + "output": "Glycosidase inhibitor described as any agent that inhibits the enzyme alpha-glucosidase located in the intestines. This prevents the breakdown of complex carbohydrates to glucose and other monosaccharides, which results in decreased intestinal absorption of monosaccharides." + }, + { + "input": "Concept: Ringing or other noises did not wake me from sleep (Finding)", + "output": "something described as a response indicating that ringing or other noises did not wake an individual from sleep." + }, + { + "input": "Concept: OUTCOME ATTRIBUTED TO ADVERSE EVENT (Result)", + "output": "Finding described as the completed action of evaluating the final state of a person who experienced an adverse event, which takes place after the adverse event occurs." + }, + { + "input": "Concept: neoplasm/cancer epidemiology (Study of epidemiology)", + "output": "Occupation or Discipline described as study of factors determining and influencing the frequency and distribution of neoplasms and cancers and their causes in a defined human population." + }, + { + "input": "Concept: grade II lymphomatoid granulomatosis (Neoplastic Process)", + "output": "Neoplastic Process described as lymphomatoid granulomatosis characterized by the presence of occasional large lymphoid cells or immunoblasts in a polymorphous background. Necrosis is more commonly seen as compared to grade I lymphomatoid granulomatosis. By in situ hybridization, EBV-positive cells are readily seen." + }, + { + "input": "Concept: dysfunction (Property or Attribute)", + "output": "something described as disturbance, impairment or abnormality of function." + }, + { + "input": "Concept: kg/mol (Unit of Dose Calculation)", + "output": "Quantitative Concept described as a unit of mass commonly used to express the molar mass of a substance in kilogram(s) per mole." + }, + { + "input": "Concept: IVIS01-Read or Access Dials (Intellectual Product)", + "output": "something described as impact of Visual Impairment Scale (IVIS) During the past 4 weeks, how difficult did you find it to read or access dials, such as on stoves, thermostats, etc.,?" + }, + { + "input": "Concept: EOSMYL (Laboratory Procedure)", + "output": "Complete Blood Count described as the determination of the number of eosinophilic myelocytes in a blood sample." + }, + { + "input": "Concept: Cutaneous livedo with nodules (Polyarteritis nodosa with single organ involvement)", + "output": "Acute skin disorder described as a form of vasculitis that involves small to medium size arteries of the dermis and subcutaneous tissue. The disorder manifests with tender subcutaneous nodules, livedo reticularis, cutaneous ulcers and necrosis; while internal organ involvement is typically spared, extra-cutaneous symptoms may be present." + }, + { + "input": "Concept: Venous malformation of the lip (Vascular malformation of the lip)", + "output": "Vascular malformation of the lip described as a vascular malformation located in the lip that is related to abnormal vascular morphogenesis." + }, + { + "input": "Concept: PSA Level Ten or Less (Laboratory or Test Result)", + "output": "something described as a blood concentration of prostate specific antigen less than or equal to 10 ng/mL." + }, + { + "input": "Concept: glutathione thioesterase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the reaction: S-acylglutathione + H(2)O = a carboxylate + glutathione + H(+)." + }, + { + "input": "Concept: mannose metabolism to fructose-6-phosphate (mannose metabolic process)", + "output": "Molecular Function described as the chemical reactions and pathways in which mannose, the aldohexose manno-hexose, is converted to fructose-6-phosphate." + }, + { + "input": "Concept: regulation of endothelial tube morphogenesis (Physiologic Function)", + "output": "Physiologic Function described as any process that modulates the frequency, rate or extent of endothelial tube morphogenesis." + }, + { + "input": "Concept: 1,2,3,4-dibenzopyrene (Carcinogenic Polycyclic Aromatic Hydrocarbon)", + "output": "Hazardous or Poisonous Substance described as a yellowish-reddish, carcinogenic aromatic hydrocarbon consisting of six fused rings and produced by the incomplete combustion of organic matter. Dibenzo[a,e]pyrene is primarily found in coal gasification products, cigarette smoke and fossil fuels. This substance is used only for research purposes to induce tumorigenesis. Dibenzo[a,e]pyrene is a mutagen and is reasonably anticipated to be a human carcinogen." + }, + { + "input": "Concept: Barbiturates (Definitive Drug Testing Procedures)", + "output": "Toxicology laboratory analyses described as the determination of the amount of barbiturate class agents present in a sample." + }, + { + "input": "Concept: LAM003 (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as an orally bioavailable immunomodulating agent with potential antineoplastic activity" + }, + { + "input": "Concept: PerformedSubstanceAdministration.doseDescription (Intellectual Product)", + "output": "something described as the textual representation of dosing amounts or a range of dosing information used in a substance administration." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Immunoassay, Therapeutic Drug, Cardiovascular, Mexiletine (Medical Device)", + "output": "IVD Test Reagent/Kits, Immunoassay, Therapeutic Drug, Cardiovascular described as immunoassay reagents intended to perform quantitative analyses on a body fluid sample (e.g., serum, plasma) to measure levels of mexiletine (an antiarrhythmia agent similar in structure and action to lidocaine that is typically used in the treatment of ventricular arrhythmias, such as life-threatening ventricular tachycardias) present in the sample. These reagents are used in tests intended to monitor mexiletine drug levels in patients undergoing treatment to determine the adequacy of therapy or to diagnose a drug-overdose or drug-related toxicity." + }, + { + "input": "Concept: FERROZINE (COLORIMETRIC) IRON BINDING CAPACITY (Indicator, Reagent, or Diagnostic Aid)", + "output": "something described as an iron-binding capacity test system is a device intended to measure iron-binding capacity in serum. Iron-binding capacity measurements are used in the diagnosis and treatment of anemia." + }, + { + "input": "Concept: Cholates (Biologically Active Substance)", + "output": "Biologically Active Substance described as salts and esters of CHOLIC ACID." + }, + { + "input": "Concept: sulprofos (Acetylcholinesterase Inhibitors)", + "output": "Acetylcholinesterase Inhibitors described as the organophosphorus agent sulprofos." + }, + { + "input": "Concept: GROUP III PHOSPHOLIPASES A 02 (Enzyme)", + "output": "something described as a subcategory of secreted phospholipases A2 with specificity for PHOSPHATIDYLETHANOLAMINES and PHOSPHATIDYLCHOLINE. It occurs as a component of VENOMS and as a mammalian secretory phospholipase A2. The creation of this group is based upon similarities in the structural determinants of the enzymes including a long amino-terminal domain, a conserved group III-specific domain, and a long carboxyl-terminal domain." + }, + { + "input": "Concept: Catheters, Intrauterine, Ultrasonography (Intrauterine catheter)", + "output": "Medical Device described as intrauterine catheters designed for infusion of saline into the uterus to enhance the transvaginal ultrasonographic image. These catheters usually include a balloon (rounded or elliptic) on or near their distal tip to be placed in the cervical canal and a central lumen for injection of the saline solution during the ultrasonic image procedure (hysterosonography). They are thin enough (e.g., 5 to 7 Fr) to allow placement next to ultrasound probes. Some of these catheters may also be used to inject opaque medium for radiographic purposes. Hysterosonographic procedures are mostly used to assist the clinician in the establishment of a specific diagnosis when endometrial thickness exist (e.g., detection of polyps)." + }, + { + "input": "Concept: positive regulation of sterigmatocystin biosynthetic process (Molecular Function)", + "output": "regulation of sterigmatocystin biosynthetic process described as any process that increases the rate, frequency, or extent of sterigmatocystin biosynthesis. Sterigmatocystin biosynthetic processes are the chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." + }, + { + "input": "Concept: Fibroodontoma (Tooth structure)", + "output": "Odontogenic Tumors described as the presence of an odontoma." + }, + { + "input": "Concept: Reflex asystolic syncope (Finding)", + "output": "Finding described as a loss of consciousness followed by stiffening and brief clonic movements affecting some or all limbs, often misinterpreted as an epileptic seizure." + }, + { + "input": "Concept: thready pulse (Conduction disorder of the heart)", + "output": "Other cardiovascular symptoms described as a diminution in the amplitude (strength) of the pulse such that the examiner has difficulty feeling the pulse. []" + }, + { + "input": "Concept: strep screen ea.tst (Laboratory Procedure)", + "output": "General laboratory tests described as analyzing a client/patient's strep screen to detect the presence of streptococcus bacteria. Service is billed per test." + }, + { + "input": "Concept: Anterior chamber flare grade 3+ (Anterior chamber flare)", + "output": "Anterior chamber flare described as marked anterior chamber flare (iris and lens details hazy)." + }, + { + "input": "Concept: Cone-shaped end part of the little finger bones (Cone-shaped epiphyses of the phalanges of the hand)", + "output": "something described as a cone-shaped appearance of the epiphyses of the 5th finger of the hand, producing a 'ball-in-a-socket' appearance. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of a phalanx." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Immunoassay, Toxicology, Ethanol Consumption Marker, Gamma-Glutamyltransferase (Medical Device)", + "output": "IVD Test Reagent/Kits, Immunoassay, Toxicology, Ethanol Consumption Marker described as immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., serum) to determine gamma-glutamyltransferase (GGT). GGT is a moderately sensitive and specific marker for long-term heavy alcohol consumption. In general, GGT is a worse marker than carbohydrate-deficient transferrin (CDT). The sensitivity of the test can be enhanced using CDT and GGT combined." + }, + { + "input": "Concept: right to treatment (Patient Rights)", + "output": "Patient Rights described as in law, the claim of persons involuntarily institutionalized on the ground of mental disability to receive appropriate care for their conditions or diseases." + }, + { + "input": "Concept: Autosomal recessive limb girdle muscular dystrophy type 2L (Disease or Syndrome)", + "output": "something described as a form of limb-girdle muscular dystrophy most often with characteristics of an adult onset (but ranging from 11 to 51 years) of mainly proximal lower limb weakness, with difficulties standing on tiptoes being one of the initial signs. Proximal upper limb and distal lower limb weakness is also common as well as atrophy of the quadriceps (most commonly), biceps brachii, and lower leg muscles. However, calf hypertrophy has also been reported in some cases. LGMD2L progresses slowly, with most patients remaining ambulatory until late adulthood." + }, + { + "input": "Concept: Full time employed (Employed)", + "output": "something described as employed for a standard number of hours of working time, at least 50% or 20 h/wk." + }, + { + "input": "Concept: 5F11 monoclonal antibody (Monoclonal Antibodies)", + "output": "something described as a fully human monoclonal antibody with potential antineoplastic activity. MDX-060 is a fully humanized antibody that targets CD30, a member of the tumor necrosis factor receptor superfamily found on activated lymphocytes. CD30 is over-expressed in various lymphoproliferative disorders, Hodgkin disease and other lymphomas, and other cancers." + }, + { + "input": "Concept: Grade 3 Hypoxic Ischemic Encephalopathy, Adverse Event (Finding)", + "output": "Hypoxic Ischemic Encephalopathy, Adverse Event described as an adverse event in a newborn characterized by moderate clinical signs (see Sarnat stages for further guidance on mild, moderate and severe clinical signs of encephalopathy) of encephalopathy resulting from a perinatal asphyxia event; meeting criteria for therapeutic hypothermia." + }, + { + "input": "Concept: cyclamate (Cyclohexanes)", + "output": "Hazardous or Poisonous Substance described as salts and esters of cyclamic acid." + }, + { + "input": "Concept: 2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone (Thiazide-like Diuretic [EPC])", + "output": "Pharmacologic Substance described as a long acting, quinazoline-based sulfonamide thiazide-like, diuretic. Similar to the thiazides, metolazone acts on the distal convoluted tubule (DCT) and inhibits the sodium-chloride symporter, thereby preventing sodium and chloride reabsorption and excretion of water." + }, + { + "input": "Concept: catabolism by organism of host xylan (Organism Function)", + "output": "catabolism by symbiont of host carbohydrate described as the chemical reactions and pathways performed by an organism resulting in the breakdown of xylan within the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." + }, + { + "input": "Concept: Immature Platelet (Cell)", + "output": "something described as a young platelet that contains residual mRNA and rRNA when released from the bone marrow into the peripheral circulation as a result of thrombopoiesis. Immature platelets normally make up a small percentage of the total circulating platelets (1.1-6.1%, with a mean of 3.4%.). An increased proportion of immature platelets in blood indicates increased thrombopoiesis. The relationship between the percent of immature platelets and the platelet count can be used to determine the rate of platelet turnover." + }, + { + "input": "Concept: adults diapers (Diaper)", + "output": "something described as absorbent pads designed to be worn as underpants or pants liners by adults." + }, + { + "input": "Concept: Decreased sensation in extremities (Central Nervous System)", + "output": "Peripheral Nervous System described as an abnormal reduction in sensation in the distal portions of the extremities." + }, + { + "input": "Concept: Herpes Simplex Virus 1 IgG Antibody (Immunologic Tests)", + "output": "Laboratory Procedure described as the determination of the amount of Herpes Simplex virus 1 IgG antibody present in a sample." + }, + { + "input": "Concept: CMD1II (Gene or Genome)", + "output": "something described as human CRYAB wild-type allele is located within 11q22.3-q23.1 and is approximately 15 kb in length. This allele, which encodes alpha-crystallin B chain protein, plays a role in maintaining the structure of the lens. Mutation of the gene is associated with myofibrillar myopathy type 2, dilated cardiomyopathy type 1II; cataract 16 and alpha-B crystallin-related, fatal infantile hypertrophy myofibrillar myopathy." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, CHM (Medical Device)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation described as molecular assay reagents intended to identify mutations in the choroideremia (CHM) gene, located at chromosome Xq21.2, which encodes for the Rab escort protein-1 (REP1) that is involved in membrane trafficking. Mutations at this locus have been identified in most patients with choroideremia (X-linked blindness) and other hereditary eye diseases." + }, + { + "input": "Concept: MSQOL-54 - Discouraged by Health Problem (Intellectual Product)", + "output": "Intellectual Product described as multiple Sclerosis Quality of Life-54 Instrument - How much of the time during the past 4 weeks: Were you discouraged by your health problems?" + }, + { + "input": "Concept: Grade 3 Urticaria (Finding)", + "output": "Finding described as urticarial lesions covering >30% BSA; IV intervention indicated" + }, + { + "input": "Concept: Sinapis (Plant)", + "output": "something described as a plant genus of the family Brassicaceae. The common name of mustard may refer to MUSTARD PLANT (BRASSICA JUNCEA or BRASSICA NIGRA)." + }, + { + "input": "Concept: germ free condition (Human-caused Phenomenon or Process)", + "output": "Human-caused Phenomenon or Process described as organisms or environments not contaminated by or associated with any viable microorganisms." + }, + { + "input": "Concept: PPP1CA Gene (Protein Serine/Threonine Phosphatase Gene)", + "output": "something described as this gene plays a role in the regulation of mitosis and glycogen metabolism." + }, + { + "input": "Concept: endocrine signaling (Intercellular Communication Process)", + "output": "Intercellular Communication Process described as the transfer of information from one cell to another, where an endocrine hormone is transported from the signal-producing cell to the receiving cell via the circulatory system (via blood, lymph or cerebrospinal fluid). The signaling cell and the receiving cell are often distant to each other." + }, + { + "input": "Concept: biosynthesis of protein-protein cross-link via L-asparagine 5-imidazolinone glycine (peptide cross-linking via 5-imidazolinone glycine)", + "output": "Molecular Function described as the formation of the fluorescent protein FP506 chromophore cross-link from the alpha-carboxyl carbon of residue n, an asparagine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." + }, + { + "input": "Concept: metal cluster binding (Binding)", + "output": "something described as interacting selectively and non-covalently with a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters." + }, + { + "input": "Concept: up-regulation of convergent extension involved in somitogenesis (Biologic Function)", + "output": "something described as any process that activates or increases the frequency, rate or extent of convergent extension involved in somitogenesis." + }, + { + "input": "Concept: K antigen biosynthetic process (Molecular Function)", + "output": "Molecular Function described as the chemical reactions and pathways resulting in the formation of a K antigen, a capsular polysaccharide antigen carried on the surface of bacterial capsules that masks somatic (O) antigens." + }, + { + "input": "Concept: Mixed tumour (Neoplasms, Complex and Mixed)", + "output": "COMPLEX MIXED AND STROMAL NEOPLASMS described as a benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth." + }, + { + "input": "Concept: Have Thrush (Intellectual Product)", + "output": "something described as a question about whether an individual has or had an oral yeast infection." + }, + { + "input": "Concept: Observational Study Time Perspective (CDISC SDTM Terminology)", + "output": "CDISC SDTM Terminology described as terminology associated with the observation study time perspective codelist of the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: glomerular mesangial cell development (epithelial cell development)", + "output": "Cell Function described as the process whose specific outcome is the progression of a glomerular mesangial cell in the kidney over time, from its formation to the mature structure." + }, + { + "input": "Concept: Microscopes, Spinning Disk Confocal (Medical Device)", + "output": "something described as microscopes with a light source delivered through an array of pinholes embedded in spinning disks. Each pinhole acts as a like a traditional confocal light source--blocking light from outside the focal plane from reaching the detector, thereby, allowing imaging of thin sections from within a thick sample. In spinning disk confocal microscopes each pinhole acts in parallel, imaging multiple locations within the sample simultaneously. The pinholes are arrayed in such a way that spinning the disk during image acquisition allows the entire field of view to be imaged in real time. Spinning disk confocal units are typically mounted on standard conventional or specially designed light microscopes (e.g., upright, inverted stage).The image data is detected, amplified, and usually digitized and displayed on a high-resolution monitor (and/or stored in the memory of a computer). These microscopes are typically used in cell and molecular biology experiments to perform in vivo imaging of fluorescently labeled molecules." + }, + { + "input": "Concept: Clips, Implantable, Eye, Iris (Clips, Implantable, Eye)", + "output": "something described as eye (ophthalmic) implantable clips designed to secure the overlapped ends of an implantable ophthalmic circling band. These clips are typically very tiny, U-shaped, metal (e.g., tantalum) devices with ends that close around the circling band. Iris-implantable clips are used in the scleral buckling technique, a surgical procedure intended for retinal reattachment." + }, + { + "input": "Concept: Preauricular dimples (Skin lesion)", + "output": "Skin Abnormalities described as small indentation anterior to the insertion of the ear." + }, + { + "input": "Concept: Iodotyrosine (Hormones)", + "output": "Hormones described as product from the iodination of tyrosine; in the biosynthesis of thyroid hormones, tyrosine is first iodized to monoiodotyrosine." + }, + { + "input": "Concept: response to iron ion starvation (response to starvation)", + "output": "something described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of iron ion." + }, + { + "input": "Concept: Friction rub, pleural (RESPIRATORY SOUNDS, SIGNS AND MECHANISMS OF SOUND PRODUCTION)", + "output": "Respiratory signs and symptoms NEC described as an abnormal breath sound that is nonmusical, short and explosive. It is grating, rubbing, creaky, or leathery in character and present in both phases of respiration. Typically the expiratory component mirrors the inspiratory component. It occurs due to inflamed pleural surface rubbing each other during breathing. Clinically, it is important to differentiate it from crackles" + }, + { + "input": "Concept: Prostate Carcinoma TNM Finding v6 (Finding)", + "output": "Genitourinary System Cancer TNM Finding v6 described as a finding about one or more characteristics of prostate cancer, following the rules of the TNM AJCC v6 classification system." + }, + { + "input": "Concept: Pegaptanib sodium (Nucleic Acid, Nucleoside, or Nucleotide)", + "output": "Pharmacologic Substance described as the sodium salt form of pegaptanib, a 28-mer RNA aptamer covalently linked to two branched 20-kD polyethylene glycol (PEG) chains, with anti-angiogenic activity. Pegaptanib binds and blocks the activity of the extracellular vascular endothelial growth factor, specifically the 165-amino acid isoform (VEGF165). This prevents VEGF165 from binding to VEGF receptors, thereby blocking angiogenesis as well as preventing VEGF165-induced increases in vessel permeability. VEGF165 is preferentially involved in pathological ocular neovascularisation." + }, + { + "input": "Concept: Acute Pyelonephritis (Nephritis, Tubulointerstitial)", + "output": "Acute infectious disease described as sudden onset pyelonephritis." + }, + { + "input": "Concept: 344 HANTANVIRUS (Virus)", + "output": "Bunyaviridae described as any viral organism that can be assigned to the genus Hantavirus." + }, + { + "input": "Concept: anal necrosis (colorectal disorders)", + "output": "colorectal disorders described as a necrotic process involving the area of the anus." + }, + { + "input": "Concept: Terminator (Manufactured Object)", + "output": "Device Component or Accessory described as a device designed to connect to the end of a bus network." + }, + { + "input": "Concept: VANCOMYCIN (Glycopeptides)", + "output": "bactericide described as a kind of antibacterial drug" + }, + { + "input": "Concept: enhancementDescription (Intellectual Product)", + "output": "something described as the textual representation for how an entity is enhanced, either physically or electronically." + }, + { + "input": "Concept: Stage IV Exocrine Pancreatic Carcinoma AJCC v8 (Pancreatic Cancer by AJCC v8 Stage)", + "output": "Pancreatic Cancer by AJCC v8 Stage described as stage IV includes: Any T, Any N, M1. M1: Distant metastasis." + }, + { + "input": "Concept: Grade 2 Autoimmune Disorder, CTCAE (Autoimmune Disorder, CTCAE)", + "output": "something described as evidence of autoimmune reaction involving a non-essential organ or function" + }, + { + "input": "Concept: NSAA116 (NSAA Clinical Classification Question)", + "output": "something described as north Star Ambulatory Assessment - Can you hop on your left leg?" + }, + { + "input": "Concept: Nomenclature (Terminology Entity)", + "output": "Terminology Entity described as application of naming conventions. Compare to vocabulary, terminology." + }, + { + "input": "Concept: RNA splicing, via endonucleolytic cleavage and ligation (Genetic Function)", + "output": "RNA Splicing described as splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." + }, + { + "input": "Concept: Atrioventricular (non-mitral, non-tricuspid) valve (Atrioventricular valve)", + "output": "Entire heart valve described as cardiac valve which has as its parts the leaf of cardiac valve that separates the atrium from the ventricle." + }, + { + "input": "Concept: short bowel syndrome (disorder of jejunum and ileum)", + "output": "Postoperative Complications described as malabsorption syndrome resulting from extensive operative resection of the small intestine, the absorptive region of the gastrointestinal tract." + }, + { + "input": "Concept: neutrons (Nucleons)", + "output": "Elementary Particles described as electrically neutral elementary particles found in all atomic nuclei except light hydrogen; the mass is equal to that of the proton and electron combined and they are unstable when isolated from the nucleus, undergoing beta decay. Slow, thermal, epithermal, and fast neutrons refer to the energy levels with which the neutrons are ejected from heavier nuclei during their decay." + }, + { + "input": "Concept: HAMD3-Weight Loss (HAMD 24 Clinical Classification Question)", + "output": "something described as hamilton Depression Rating Scale-24 Item (HAMD 24) Weight loss." + }, + { + "input": "Concept: RR Interval, Single Measurement (Quantitative Concept)", + "output": "ECG Measurement described as an electrocardiographic measurement of the interval between two consecutive R waves. If R waves are not present, this measurement may utilize the interval between the most easily identified components of the QRS complex within two consecutive beats." + }, + { + "input": "Concept: Parathyroid dysgenesis (Anatomical Abnormality)", + "output": "Abnormality of the parathyroid morphology described as abnormal embryonic development of the parathyroid gland." + }, + { + "input": "Concept: Aeromonas, NOS (Aeromonadaceae)", + "output": "Fermentative Gram-negative bacillus described as any bacteria that is not assigned to the species level but can be assigned to the Aeromonas genus level." + }, + { + "input": "Concept: Global proximal tubulopathy (Disease or Syndrome)", + "output": "Proximal tubulopathy described as a type of proximal renal tubulopathy characterized by resorption defects leading to glycosuria, aminoaciduria, tubular proteinuria, renal hypophosphatemia, and urate tubular hyporeabsorption with bicarbonate loss and resulting acidosis." + }, + { + "input": "Concept: Penile Erectile Alteration (Male Reproductive System Alteration)", + "output": "Organ or Tissue Function described as penile Erectile Alteration involves a change in quality of the ability of the penis to achieve and maintain an erection. Mechanisms of alteration include induction or inhibition of blood flow to the corpus cavernosa and nerve stimuli to the penile musculature." + }, + { + "input": "Concept: regulation of salivary gland boundary specification (regulation of animal organ formation)", + "output": "regulation of animal organ formation described as any process that modulates the frequency, rate or extent of salivary gland determination." + }, + { + "input": "Concept: Grade 4 Periorbital Infection, CTCAE (Periorbital Infection, CTCAE)", + "output": "Finding described as life-threatening consequences; urgent intervention indicated" + }, + { + "input": "Concept: Ellagic Acid/Annona muricata Supplement (Dietary Supplements)", + "output": "Pharmacologic Substance described as a nutritional supplement containing the phytochemical polyphenol, ellagic acid, and an extract of Annona muricata, with potential chemopreventive activity. Although the exact mechanism of action for ellagic acid has yet to be fully elucidated, this agent acts as an anti-oxidant and reduces oxidative stress. This agent also appears to protect the body against certain carcinogens, either through preventing DNA binding or by increasing the rate of their metabolism and deactivation. Certain extracts of Annona muricata, a member of the custard apple plants and belonging to the Annonaceae family, may have antiviral activity, potential targets include human papilloma virus (HPV), and may be cytotoxic against various types of cancer cells." + }, + { + "input": "Concept: Zone of kidney (Organ zone)", + "output": "Organ zone described as organ zone in the kidney." + }, + { + "input": "Concept: hu3F8 x huOKT3 Bispecific Antibody (Antineoplastic Antibody)", + "output": "Bispecific Monoclonal Antibodies described as a bispecific antibody comprised of a humanized anti-CD3 OKT3 (huOKT3) single chain variable fragment (scFv), linked to the carboxyl end of a humanized anti-GD2 3F8 (hu3F8) immunoglobulin G1 (IgG1) light chain, with potential antineoplastic activity. Upon intravenous administration, the anti-GD2 hu3F8/anti-CD3 huOKT3 bispecific antibody binds to CD3 on T-cells and disialoganglioside GD2 expressed on certain tumor cells, thereby cross-linking T-cells with GD2-expressing tumor cells. This promotes a selective cytotoxic T-lymphocyte (CTL) response against GD2-expressing cells. The Fc region of the anti-GD2 hu3F8/anti-CD3 huOKT3 bispecific antibody has two amino acid substitutions, N297A and K322A, which may prevent cytokine release syndrome and other unwanted side effects including complement-mediated pain. GD2, a disialoganglioside and tumor-associated antigen (TAA), is overexpressed in a variety of tumor cell types. CD3 is part of the functional T-cell receptor (TCR) complex, which is necessary for antigen recognition by T-cells and is required for signal transduction." + }, + { + "input": "Concept: Adenocarcinoma of anal canal (Malignant neoplasm of anal canal)", + "output": "Malignant tumor of digestive organ described as an adenoma carcinoma that originates in the anal canal." + }, + { + "input": "Concept: FIBROBLAST GROWTH FACTOR A 006 (Fibroblast Growth Factor)", + "output": "something described as a fibroblast growth factor that was initially identified based on its sequence similarity to FIBROBLAST GROWTH FACTOR 4. It is found in MYOBLASTS and plays an important role in MUSCLE DEVELOPMENT." + }, + { + "input": "Concept: SUTRT (Intellectual Product)", + "output": "Name described as the literal identifier of the substance in use." + }, + { + "input": "Concept: Pseudomonas fragariae (Pseudomonas)", + "output": "Pseudomonas described as a species of gram-negative, aerobic bacteria in the genus PSEUDOMONAS. It has a characteristic strawberry color and is widely distributed in SOIL and WATER." + }, + { + "input": "Concept: lactose, unspecified form (Drug allergens)", + "output": "Drug allergens described as a type of sugar found in milk and milk products." + }, + { + "input": "Concept: chloroplast-nucleus signalling pathway (Molecular Function)", + "output": "Signal Transduction described as the process in which a molecular signal is transduced between the chloroplast and nucleus, such that expression of nuclear encoding photosynthetic proteins is coupled with chloroplast biogenesis." + }, + { + "input": "Concept: Hyperextensible hand joints (Range of joint movement increased)", + "output": "Hand described as the ability of the joints of the hand to move beyond their normal range of motion." + }, + { + "input": "Concept: Stylus septi (Body Part, Organ, or Organ Component)", + "output": "something described as a composite structure of the endbrain that consists of the septal nuclei and the nucleus accumbens ( Riley-1943 )." + }, + { + "input": "Concept: Factory Smokestack Smoke Exposure (Finding)", + "output": "something described as environmental or occupational exposure to airborne gases and particulates emitted by a factory smokestack." + }, + { + "input": "Concept: PP (Intellectual Product)", + "output": "something described as a findings domain that contains pharmacokinetic parameters derived from pharmacokinetic concentration-time (PC) data." + }, + { + "input": "Concept: cytosolic AhR complex location (aryl hydrocarbon receptor complex)", + "output": "Cell Component described as an aryl hydrocarbon receptor complex found in the cytosol, in which the ligand-binding subunit AhR is not bound to ligand; consists of AhR, two molecules of HSP90, the protein kinase c-Src, and the immunophilin XAP2/AIP." + }, + { + "input": "Concept: Shields, X-Ray, Eye (Medical Device)", + "output": "something described as x-ray radiation shields, usually cup-shaped lead-glass lenses held by a cord to fit to the patient or healthcare worker. These shields are designed for protection of the patient's eye lens during therapeutic and diagnostic imaging procedures." + }, + { + "input": "Concept: IP (Therapeutic or Preventive Procedure)", + "output": "Therapeutic or Preventive Procedure described as the administration of pharmaceutical agents directly into the abdominal or peritoneal cavity. This technique is widely utilized for the chemotherapeutic treatment of advanced ovarian cancer." + }, + { + "input": "Concept: Servo (Medical Device)", + "output": "something described as an electronic device designed to amplify the force of a movement." + }, + { + "input": "Concept: PROBE, RADIOFREQUENCY LESION (Medical Device)", + "output": "something described as a radiofrequency lesion probe is a device connected to a radiofrequency (RF) lesion generator to deliver the RF energy to the site within the nervous system where a lesion is desired." + }, + { + "input": "Concept: Calvarial doughnut lesion with bone fragility syndrome (Congenital anomaly of skull)", + "output": "Disease or Syndrome described as this syndrome has characteristics of multiple doughnut-shaped hyperostotic or osteosclerotic lesions of the calvaria. It has been observed in approximately 20 individuals. Clinical manifestations include the presence of cranial lumps, numerous pathologic fractures, elevated serum alkaline phosphatase levels, and dental caries. Transmission is autosomal dominant." + }, + { + "input": "Concept: Cyclophilin F (Enzyme)", + "output": "Enzyme described as peptidyl-prolyl cis-trans isomerase F, mitochondrial (207 aa, ~22 kDa) is encoded by the human PPIF gene. This protein is involved in the regulation of both cell death and protein folding." + }, + { + "input": "Concept: Galactosephosphates (Organic Chemical)", + "output": "something described as phosphoric acid esters of galactose." + }, + { + "input": "Concept: Help-Seeking Behaviors (Individual Behavior)", + "output": "specific attitude and behavior described as searching for or requesting help from others through formal or informal mechanisms." + }, + { + "input": "Concept: Refractory Osteosarcoma (Neoplastic Process)", + "output": "Neoplastic Process described as osteosarcoma that does not respond to treatment." + }, + { + "input": "Concept: Shared Neoantigen-Positive Malignant Solid Tumor (Neoplastic Process)", + "output": "Neoantigen-Positive Malignant Solid Neoplasm described as a malignant solid neoplasm that expresses unique tumor-specific neoantigens across a subset of patients." + }, + { + "input": "Concept: mirex/kepone (Organic Chemical)", + "output": "something described as carcinogenic organochlorine insecticide." + }, + { + "input": "Concept: Primary acquired melanosis (Mass in head or neck)", + "output": "Soft tissue lesion described as an acquired pigmentation of the conjunctival epithelium associated with benign or atypical melanocytic hyperplasia. It usually affects adult Caucasians, is most often unilateral, and may progress to conjunctival melanoma." + }, + { + "input": "Concept: infection stoma site (Infections NEC)", + "output": "Infections NEC described as an infectious process affecting a surgically created opening in the surface of the body." + }, + { + "input": "Concept: uridine diphosphoglucose-fructose glucosyltransferase activity (phenol beta-glucosyltransferase activity)", + "output": "phenol beta-glucosyltransferase activity described as catalysis of the reaction: UDP-glucose + D-fructose = UDP + sucrose." + }, + { + "input": "Concept: oxygen compound (Inorganic Chemical)", + "output": "Chemicals described as tree heading term for oxygen-containing chemicals." + }, + { + "input": "Concept: Wu wei zi (Plant)", + "output": "Schisandra described as dried fruit of SCHISANDRA chinensis or S. sphenanthera which is used medicinally." + }, + { + "input": "Concept: thioredoxin (Proteins)", + "output": "Biologically Active Substance described as hydrogen-donating proteins that participates in a variety of biochemical reactions including ribonucleotide reduction and reduction of PEROXIREDOXINS. Thioredoxin is oxidized from a dithiol to a disulfide when acting as a reducing cofactor. The disulfide form is then reduced by NADPH in a reaction catalyzed by THIOREDOXIN REDUCTASE." + }, + { + "input": "Concept: urachus (Median umbilical fold)", + "output": "Urinary Bladder described as a cord of fibrous tissue that extends from the urinary bladder to the umbilicus. The urachus is a remnant of the fetal urinary canal." + }, + { + "input": "Concept: tRNA Amino Acyl (Biologically Active Substance)", + "output": "Amino Acid, Peptide, or Protein described as intermediates in protein biosynthesis. The compounds are formed from amino acids, ATP and transfer RNA, a reaction catalyzed by aminoacyl tRNA synthetase. They are key compounds in the genetic translation process." + }, + { + "input": "Concept: pmol/d (Molality Unit)", + "output": "something described as a unit of amount of substance flow rate equivalent to the rate at which one picomole of substance travels to a given object or space over a period of time equal to 24 hours." + }, + { + "input": "Concept: day*g/mL/m2 (Quantitative Concept)", + "output": "something described as days times grams per milliliter, divided by meters squared." + }, + { + "input": "Concept: Dispensers (Device associated with dispensers)", + "output": "Device associated with dispensers described as device for the dispensing of a specified quantity of a medicinal product, for example an automatic electronic counter. Comment: Pre-filled pens, pre-filled syringes, inhalers, metering pumps, etc. are excluded." + }, + { + "input": "Concept: Flaxseed (F [Preparations])", + "output": "Non-Standardized Plant Allergenic Extract described as seed isolated from one of several species of the plant genus Linum. Flaxseed-derived foods, lignans, and essential fatty acids such as alpha-linolenic acid, possess anti-inflammatory, lipid-lowering, antioxidant, and antineoplastic properties." + }, + { + "input": "Concept: Keloid cicatrix (Skin dystrophy)", + "output": "Excessive repair described as an irregularly shaped, elevated mark on the skin caused by deposits of excessive amounts of collagen during wound healing. It extends beyond the original boundaries of the wound and may enlarge progressively." + }, + { + "input": "Concept: bronchial disorders (Disorder of lower respiratory system)", + "output": "Respiration Disorders described as condition in which there is a deviation from or interruption of the normal structure or function of the bronchi." + }, + { + "input": "Concept: MiHA-loaded PD-L-silenced DC Vaccine (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as a dendritic cell (DC)-based vaccine composed of program death ligands 1 and 2 (PDL1/L2)-silenced DCs and loaded with the recipient's minor histocompatibility antigens (MiHA), with potential use for graft-versus-tumor (GVT) induction following allogeneic stem cell transplantation (allo-SCT). Donor DCs are electroporated ex vivo with MiHA mRNA and small interfering RNAs (siRNAs) designed to silence the expression of PD L1/L2. After allo-SCT and upon intravenous administration of the MiHA-loaded PD-L1/L2-silenced DC vaccine, the DCs induce the expansion and activation of MiHA-specific CD8-positive T-cells. These tumor antigen-reactive T-cells exert their GVT effect by killing miHA-positive tumor cells. PD-L1/L2, co-inhibitory ligands expressed on DCs, play key roles in preventing MiHA-specific CD8-positive T-cell expansion; silencing enhances MiHA-specific CD8-positive T-cell expansion and activity and improves the GVT effect. The MiHA are human leukocyte antigen (HLA)-bound peptides and are exclusively expressed by the recipient's hematopoietic tumor cells." + }, + { + "input": "Concept: rho Guanine Nucleotide Dissociation Inhibitor beta (rho-Specific Guanine Nucleotide Dissociation Inhibitors)", + "output": "something described as a rho GDP-dissociation inhibitor subtype that is highly expressed in hematopoietic cells and in LYMPHOCYTES. The expression of this subtype is associated with the regulation of CELL PROLIFERATION; TUMORIGENESIS; and APOPTOSIS." + }, + { + "input": "Concept: Thyroidinum / thyroid gland (Homeopathic remedies letter T)", + "output": "something described as thyroid gland." + }, + { + "input": "Concept: CDRS1-Difficulty Having Fun Comment (Intellectual Product)", + "output": "something described as children's Depression Rating Scale, Revised (CDRS-R) Difficulty having fun comment." + }, + { + "input": "Concept: negative regulation of prostatic bud formation (Biologic Function)", + "output": "Biologic Function described as any process that decreases the rate, frequency, or extent of prostatic bud formation, the morphogenetic process in which a region of the fetal urogenital sinus epithelium is specified to become the prostate, resulting in prostate bud outgrowth." + }, + { + "input": "Concept: Hemoglobin A to Total Hemoglobin Ratio Measurement (Laboratory Procedure)", + "output": "Hemoglobin measurement described as the determination of the ratio of Hemoglobin A compared to total Hemoglobin present in a sample. The measurement may be expressed as a ratio or percentage." + }, + { + "input": "Concept: sucrose catabolic process to fructose-6-phosphate through glucose and fructose (sucrose catabolic process)", + "output": "something described as the chemical reactions and pathways resulting in the breakdown of sucrose, to yield fructose-6-phosphate through both glucose and fructose intermediates." + }, + { + "input": "Concept: Lithium Iodide Battery (Manufactured Object)", + "output": "something described as a battery consisting of a lithium anode and a cathode of iodine and poly-2-vinyl pyridine. They are especially useful in devices like pacemakers because of their long life." + }, + { + "input": "Concept: protein reconstitution (Molecular Function)", + "output": "Molecular Function described as returning of denatured protein to its original structure and activity; an unfolded polypeptide chain returning to its normal folded three-dimensional structure." + }, + { + "input": "Concept: rV-PSA (Immunologic Factor)", + "output": "Vaccinia Vaccine described as a recombinant vaccinia virus encoding prostate-specific antigen (PSA). Vaccination with recombinant vaccinia-PSA may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for PSA, which may decrease tumor growth." + }, + { + "input": "Concept: Chronic intestinal candidiasis (Disease or Syndrome)", + "output": "something described as persistent overgrowth of Candida albicans in the gastrointestinal tract." + }, + { + "input": "Concept: MRP-L45 (MRPL45 gene)", + "output": "MRPL45 gene described as human MRPL45 wild-type allele is located in the vicinity of 17q21.2 and is approximately 26 kb in length. This allele, which encodes 39S ribosomal protein L45, mitochondrial, plays a role in the translation of mitochondrial RNA." + }, + { + "input": "Concept: Abnormal cerebrospinal fluid biopterin level (Abnormal cerebrospinal fluid metabolite concentration)", + "output": "Abnormal CSF metabolite level described as abnormal concentration of biopterin in the cerebrospinal fluid (CSF). []" + }, + { + "input": "Concept: CKD-MBD - chronic kidney disease mineral and bone disorder (Chronic Kidney Diseases)", + "output": "something described as decalcification of bone or abnormal bone development due to chronic KIDNEY DISEASES, in which 1,25-DIHYDROXYVITAMIN D3 synthesis by the kidneys is impaired, leading to reduced negative feedback on PARATHYROID HORMONE. The resulting SECONDARY HYPERPARATHYROIDISM eventually leads to bone disorders." + }, + { + "input": "Concept: detection of glucocorticoid hormone stimulus (response to glucocorticoid)", + "output": "Cell Function described as the series of events by which a glucocorticoid hormone stimulus is received by a cell and converted into a molecular signal. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." + }, + { + "input": "Concept: regulation of vasculature development (Physiologic Function)", + "output": "Physiologic Function described as any process that modulates the frequency, rate or extent of vasculature development." + }, + { + "input": "Concept: Black cohosh (Plant product)", + "output": "Organic Chemical described as an eastern North American perennial herb. A substance obtained from the root of the plant has been used in some cultures to treat a number of medical problems. It is being studied in the treatment of hot flashes and other symptoms of menopause. The scientific name is Cimicifuga racemosa." + }, + { + "input": "Concept: ABSCESS PERIANAL (Perianal lump)", + "output": "Inflammation of large intestine described as an abscess that develops in the soft tissues surrounding the anal canal. Causes include bacterial and fungal infections, malignancies that involve the perianal region, and Crohn disease." + }, + { + "input": "Concept: L-xylitol metabolism (Molecular Function)", + "output": "pentitol metabolic process described as the chemical reactions and pathways involving L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. It is as sweet as sucrose and is used as a noncariogenic sweetner and as a sugar substitute in diabetic diets." + }, + { + "input": "Concept: hemadsorption inhibition test (Laboratory Procedure)", + "output": "Inhibition test described as serological tests that measure anti-hemadsorption agents such as antiviral ANTIBODIES that block VIRAL HEMAGGLUNININS from adhering to the surface of red blood cells." + }, + { + "input": "Concept: imaginal disc-derived appendage development (Organism Function)", + "output": "appendage development described as the process whose specific outcome is the progression of an appendage over time, from its formation in the imaginal disc to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism." + }, + { + "input": "Concept: Stage I Mycosis Fungoides and Sezary Syndrome AJCC v8 (Mycosis Fungoides and Sezary Syndrome by AJCC v8 Stage)", + "output": "Neoplastic Process described as stage I includes: IA (T1, N0, M0, B0,1); IB (T2, N0, M0, B0,1). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. T2: Patches, papules, or plaques covering 10% or more of the skin surface. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2." + }, + { + "input": "Concept: cellular response to chemical stimulus (cellular response to stimulus)", + "output": "Cell Function described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." + }, + { + "input": "Concept: ED208 7 (Intellectual Product)", + "output": "something described as expanded Disability Rating Scale - Postacute Interview Survivor Version (Expanded DRS-PI Survivor Version) How certain are you that you can be able to work at home or in a special setting like a sheltered workshop in which the work is very routine and there is very frequent supervision and support?" + }, + { + "input": "Concept: Esophagus and Esophagogastric Junction Cancer TNM Finding v8 (Finding)", + "output": "Upper Gastrointestinal Tract Cancer TNM Finding v8 described as a finding about one or more characteristics of esophagus and esophagogastric junction cancer, following the rules of the TNM AJCC v8 classification system. This staging system applies to carcinomas including squamous cell carcinoma, adenocarcinoma, adenosquamous carcinoma, undifferentiated carcinoma, neuroendocrine cancers, and adenocarcinoma with neuroendocrine features. Sarcomas, nonepithelial cancers, and gastrointestinal stromal tumors are not staged using this staging system." + }, + { + "input": "Concept: Vaginal Germ Cell Tumor (Vaginal Neoplasms)", + "output": "Germ cell tumor described as a germ tumor that arises from the vagina." + }, + { + "input": "Concept: methanol extraction residue of BCG (Immunologic Factor)", + "output": "something described as a cell wall fraction of bacillus Calmette-Guerin (BCG) obtained by menthol extraction with immunomodulating properties and potential use in cancer immunotherapy. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1159\" active clinical trials using this agent." + }, + { + "input": "Concept: Carcinomatoses (Neoplasm, malignant, uncertain whether primary or metastatic)", + "output": "Epithelioma described as a condition in which cancer is spread widely throughout the body, or, in some cases, to a relatively large region of the body." + }, + { + "input": "Concept: Severe Malaria (Malaria)", + "output": "Malaria described as acute malaria with signs of organ dysfunction, severe anemia (hemoglobin less than 5 g/dL or hematocrit less than 15%) and/or hyperparasitemia (greater than 5% of red blood cells infected)." + }, + { + "input": "Concept: Gastric Gastrin-Producing Neuroendocrine Tumor (Gastric Neuroendocrine Tumor)", + "output": "something described as a well differentiated neuroendocrine tumor that arises from the stomach. It produces gastrin and it may be associated with Zollinger-Ellison syndrome." + }, + { + "input": "Concept: CONNECTOR, BLOOD TUBING, INFUSION \"T\" (Medical Device)", + "output": "Medical Device described as a hemodialysis system and accessories is a device that is used as an artificial kidney system for the treatment of patients with renal failure or toxemic conditions and that consists of an extracorporeal blood system, a conventional dialyzer, a dialysate delivery system, and accessories. Blood from a patient flows through the tubing of the extracorporeal blood system and accessories to the blood compartment of the dialyzer, then returns through further tubing of the extracorporeal blood system to the patient. The dialyzer has two compartments that are separated by a semipermeable membrane. While the blood is in the blood compartment, undesirable substances in the blood pass through the semipermeable membrane into the dialysate in the dialysate compartment. The dialysate delivery system controls and monitors the dialysate circulating through the dialysate compartment of the dialyzer. (1) The extracorporeal blood system and accessories consists of tubing, pumps, pressure monitors, air foam or bubble detectors, and alarms to keep blood moving safely from the blood access device and accessories for hemodialysis (Sec. 876.5540) to the blood compartment of the dialyzer and back to the patient. (2) The conventional dialyzer allows a transfer of water and solutes between the blood and the dialysate through the semipermeable membrane. The semipermeable membrane of the conventional dialyzer has a sufficiently low permeability to water that an ultrafiltration controller is not required to prevent excessive loss of water from the patient's blood. This conventional dialyzer does not include hemodialyzers with the disposable inserts (Kiil type) (Sec. 876.5830) or dialyzers of high permeability (Sec. 876.5860). (3) The dialysate delivery system consists of mechanisms that monitor and control the temperature, conductivity, flow rate, and pressure of the dialysate and circulates dialysate through the dialysate compartment of the dialyzer. The dialysate delivery system includes the dialysate concentrate for hemodialysis (liquid or powder) and alarms to indicate abnormal dialysate conditions. This dialysate delivery system does not include the sorbent regenerated dialysate delivery system for hemodialysis (Sec. 876.5600), the dialysate delivery system of the peritoneal dialysis system and accessories (Sec. 876.5630), or the controlled dialysate delivery system of the high permeability hemodialysis system (Sec. 876.5860). (4) Remote accessories to the hemodialysis system include the unpowered dialysis chair without a scale, the powered dialysis chair without a scale, the dialyzer holder set, dialysis tie gun and ties, and hemodialysis start/stop tray." + }, + { + "input": "Concept: SPARTALIZUMAB (Immunologic Factor)", + "output": "Immunologic Factor described as a humanized monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed death-1 (PD-1, PCD-1), with immune checkpoint inhibitory and antineoplastic activities. Upon administration, spartalizumab binds to PD-1 expressed on activated T-cells and blocks the interaction with its ligands, programmed cell death 1 ligand 1 (PD-L1, PD-1L1) and PD-1 ligand 2 (PD-L2, PD-1L2). The inhibition of ligand binding prevents PD-1-mediated signaling and results in both T-cell activation and the induction of T-cell-mediated immune responses against tumor cells. PD-1, an immunoglobulin (Ig) superfamily transmembrane protein and inhibitory receptor, negatively regulates T-cell activation. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C121625\" active clinical trials using this agent." + }, + { + "input": "Concept: PerformedProcedure.targetAnatomicSiteConditionCode (Target Anatomic Site Condition Code)", + "output": "Intellectual Product described as a coded value specifying the state of the target anatomic site. EXAMPLE(S): The subject's left arm was bruised where the IV was inserted." + }, + { + "input": "Concept: SITagliptin phosphate (Organic Chemical)", + "output": "Pharmacologic Substance described as the phosphate salt form of sitagliptin, an orally available, competitive, beta-amino acid-derived inhibitor of dipeptidyl peptidase 4 (DDP-4) with hypoglycemic activity. Sitagliptin may cause an increased risk in the development of pancreatitis." + }, + { + "input": "Concept: Intracranial Aneurysm (Disorder of soft tissue of body cavity)", + "output": "Intracerebral vascular finding described as a congenital or acquired aneurysm within the cranium." + }, + { + "input": "Concept: SGOT - Glutamate oxaloacetate transaminase (Transaminases)", + "output": "Amino Acid, Peptide, or Protein described as activity measured as a test of liver function, 46/47-kDa homodimeric human Aspartate Aminotransferases (Class-I Pyridoxal-Phosphate-Dependent Aminotransferase Family) are pyridoxal phosphate-dependent enzymes involved in amino acid metabolism and in the urea and tricarboxylic acid cycles." + }, + { + "input": "Concept: Medicated Swab Dose Form (Swab Dosage Form)", + "output": "Biomedical or Dental Material described as a solid composed of active and/or inert ingredient(s) on a small piece of absorbent material attached to one end of a stick." + }, + { + "input": "Concept: MEDEVAL (Intellectual Product)", + "output": "something described as terminology associated with the medical evaluator codelist of the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Microbiology, Bacteria, Identification, Helicobacter pylori (Medical Device)", + "output": "IVD Test Reagent/Kits, Microbiology, Bacteria, Identification described as microbiology reagents intended to identify Helicobacter (formerly Campylobacter) pylori, a bacterium of the genus Helicobacter, family Spirillaceae. These bacteria cause chronic gastritis and pyloric ulcer and could be an etiologic agent for gastric cancer." + }, + { + "input": "Concept: Folate-dependent fragile site at Xq28 (Finding)", + "output": "LABORATORY ABNORMALITIES described as the presence of a folate sensitive fragile site at chromosome Xq28." + }, + { + "input": "Concept: ADL03-Talk About at Home Events (ADCS-ADL MCI Questionnaire Question)", + "output": "ADCS-ADL MCI Questionnaire Question described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, MCI Version - Did {S} talk about events that occurred at home that he/she took part in or watched?" + }, + { + "input": "Concept: PF4 Gene (CXC Cytokine Gene)", + "output": "something described as this gene plays a role in platelet aggregation and promotes blood coagulation." + }, + { + "input": "Concept: Mycobacterium tuberculosis IgG Antibody Measurement (Laboratory Procedure)", + "output": "something described as a measurement of the Mycobacterium tuberculosis IgG antibodies in a biological specimen." + }, + { + "input": "Concept: protein desuccinylation (Molecular Function)", + "output": "Molecular Function described as the removal of a succinyl group (CO-CH2-CH2-CO) from a residue in a peptide or protein." + }, + { + "input": "Concept: Ataxia with tapetoretinal degeneration syndrome (Chorioretinal degeneration)", + "output": "Atrophic retina described as a rare hereditary ataxia with characteristics of simultaneous onset and development of cerebellar ataxia and chorioretinal degeneration (including macular degeneration, advancing choroidal sclerosis, punctata albescens, and retinitis pigmentosa). There have been no further descriptions in the literature since 1963." + }, + { + "input": "Concept: anti-CD19-CAR retroviral vector-transduced autologous T cells (therapeutic autologous lymphocytes)", + "output": "Chimeric Antigen Receptor T-cells described as a preparation of autologous peripheral blood T-lymphocytes (PBTL) that have been genetically modified to express a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment); an extracellular portion of human CD28 and the entire transmembrane and cytoplasmic portion of human CD28; and the cytoplasmic portion of the human TCR-[zeta] molecule with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19-CAR retroviral vector-transduced autologous T cells may stimulate host cytotoxic T lymphocyte (CTL) and antibody responses against CD19-expressing tumor cells, resulting in tumor cell lysis. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. CD3 zeta is one of several membrane-bound polypeptides found in the T-cell receptor (TCR)/CD3 complex and regulates the assembly of complete TCR complexes and their expression on the cell surface. CD28 is essential for CD4+ T-cell proliferation, interleukin-2 production, and T-helper type-2 (Th2) development. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C88055\" active clinical trials using this agent." + }, + { + "input": "Concept: glutamic-type endopeptidase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism involving a glutamate/glutamine catalytic dyad." + }, + { + "input": "Concept: Thyroid Cancer Clinical TNM Finding v7 (Thyroid Cancer TNM Finding v7)", + "output": "something described as a clinical finding about one or more characteristics of thyroid cancer, following the rules of the TNM AJCC v7 classification system. The assessment of a thyroid tumor depends on inspection and palpation of the thyroid gland and regional lymph nodes. Indirect laryngoscopy to evaluate vocal cord motion is essential. A variety of imaging procedures can provide additional useful information. These include radioisotope thyroid scans, ultrasonography, computed tomography scans (CT), magnetic resonance imaging (MRI) scans, and PET scans. The diagnosis of thyroid cancer must be confirmed by needle biopsy or open biopsy of the tumor." + }, + { + "input": "Concept: ochronosis (Abnormality of skin morphology)", + "output": "Alkaptonuria described as brown or blue-gray discoloration of the skin tha can present on the axillary and inguinal areas, face, palms or soles. In addition, blue-black discoloration can be apparent on skin overlying cartilage in which the pigment is deposited, such as the ears. This is a characteristic manifestation of alkaptonuria, which is an autosomal recessively inherited deficiency of homogentisic acid oxidase that results in accumulation of homogentisic acid in collagenous structures. The sclerae are also typically involved." + }, + { + "input": "Concept: syntactic (Speech)", + "output": "Property or Attribute described as study and rules of the relation of morphemes to one another as expressions of ideas and as structural components of sentences; the study and science of sentence construction; and, the actual grouping and specific combination and relationship of words in a sentence. Compare GRAMMAR and SENTENCE STRUCTURE." + }, + { + "input": "Concept: aflatoxin metabolic process (mycotoxin metabolic process)", + "output": "mycotoxin metabolic process described as the chemical reactions and pathways involving aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450." + }, + { + "input": "Concept: Premature chromatid separation (Cell or Molecular Dysfunction)", + "output": "Abnormality of chromosome segregation described as the presence of premature sister chromatid segregation." + }, + { + "input": "Concept: stage IIA gallbladder cancer AJCC v8 (Neoplastic Process)", + "output": "Neoplastic Process described as stage IIA includes: T2a, N0, M0. T2a: Tumor invading the perimuscular connective tissue on the peritoneal side, without involvement of the serosa (visceral peritoneum). N0: No regional lymph node metastasis. M0: No distant metastasis." + }, + { + "input": "Concept: perireuniens nucleus (Body Part, Organ, or Organ Component)", + "output": "something described as a cell group located in the thalamus of the rat ( Swanson-2004 ) and the mouse ( Dong-2004 ). It is found deep to the submedial nucleus between the reuniens nucleus and the medial part of the ventral lateral nucleus. In the Functional CNS Model - Rat it is one of three nuclei in the medial group of the dorsal thalamus, which is in turn a component of the polymodal association thalamus (see Models Where It Appears below )." + }, + { + "input": "Concept: Stage II Aggressive Adult Non-Hodgkin Lymphoma (Aggressive Adult Non-Hodgkin Lymphoma)", + "output": "Neoplastic Process described as stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3)." + }, + { + "input": "Concept: cysts mesentery (Congenital digestive system anomalies)", + "output": "Mass of digestive structure described as a rare intra-abdominal tumor in the MESENTERY. Mesenteric cysts are usually benign and can be very large fluid-filled (2000 mL) lesions." + }, + { + "input": "Concept: trehalose biosynthesis involved in ascospore formation (trehalose biosynthetic process)", + "output": "something described as any trehalose biosynthetic process that is involved in ascospore formation." + }, + { + "input": "Concept: Unfiltered (General Qualifier)", + "output": "General Qualifier described as lacking a filter." + }, + { + "input": "Concept: up-regulation of formation of growth cone in injured axon (Cell Function)", + "output": "something described as any process that activates or increases the frequency, rate or extent of formation of growth cone in injured axon." + }, + { + "input": "Concept: DDS0233 (PARENT-DDS Questionnaire Question)", + "output": "Intellectual Product described as diabetes Distress Scale for Parents of Teens with Type 1 Diabetes - Healthcare team distress: Sum of 2 items (11, 16)." + }, + { + "input": "Concept: protein-phycocyanobilin linkage (protein-bilin linkage)", + "output": "something described as the linkage of the chromophore phycocyanobilin to phycocyanin or allophycocyanin." + }, + { + "input": "Concept: Stage III Rectosigmoid Cancer (Rectosigmoid Cancer by AJCC v6 Stage)", + "output": "Neoplastic Process described as stage III includes: IIIA (T1-T2, N1, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0). N1: Metastasis in 1 to 3 regional lymph nodes. N2: Metastasis in 4 or more regional lymph nodes. M0: No distant metastasis." + }, + { + "input": "Concept: 1q42 (Cell Component)", + "output": "something described as a chromosome band present on 1q" + }, + { + "input": "Concept: pediatric neurology oncology (Pediatric neurology)", + "output": "Pediatrics described as a branch of neurologic oncology that focuses on cancers in children." + }, + { + "input": "Concept: cell differentiation involved in embryonic placenta development (developmental process involved in reproduction)", + "output": "something described as the process in which a relatively unspecialized cell acquires specialized features of the embryonic placenta." + }, + { + "input": "Concept: H5N2 Virus (influenza A virus)", + "output": "Virus described as a subtype of INFLUENZA A VIRUS comprised of the surface proteins hemagglutinin 5 and neuraminidase 2. The H5N2 subtype has been found to be highly pathogenic in chickens." + }, + { + "input": "Concept: Acridine orange stain test (Microbial staining)", + "output": "Staining method described as a microscopy staining method that utilizes acridine orange, a fluorescent cationic dye that is selective for nucleic acids, to determine the presence of viable cells or microorganisms in a sample. Acridine orange interacts with RNA and DNA and the lysosomal compartment of cells." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, ATL1 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation described as molecular assay reagents intended to identify mutations in the atlastin GTPase 1 (ATL1) gene, located at chromosome 14q22.1, which encodes the protein atlastin-1. Genetic variants at this locus have been associated with hereditary sensory neuropathy type 1d and spastic paraplegia 3." + }, + { + "input": "Concept: Giant Toads (Amphibian)", + "output": "Genus Rhinella described as a species of the true toads, Bufonidae, becoming fairly common in the southern United States and almost pantropical. The secretions from the skin glands of this species are very toxic to animals." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, ASPA (Medical Device)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation described as molecular assay reagents intended to identify mutations in the aspartoacylase (aminoacylase 2) (ASPA) gene, located at chromosome 17p13.3, which encodes for an enzyme that breaks down N-acetyl-L-aspartic acid (NAA) into aspartic acid and acetic acid. NAA is critical for maintaining the white matter of the brain and may also play a role in transporting water molecules out of nerve cells. Mutations at this locus have been identified in most patients with a type of leukodystrophy known as Canavan's disease (CD). The disease is also known as Canavan-van-Bogaert Bertrand disease." + }, + { + "input": "Concept: Meniscus of joint, NOS (Types and Parts of Joints)", + "output": "Body Part, Organ, or Organ Component described as cartilaginous material that serves as a cushion between the tuberosities of the femur and the tibia." + }, + { + "input": "Concept: Cells, Tr1 (Cell)", + "output": "something described as CD25-negative regulatory cells found in the mucosal immune system. They secrete IL-10 and TGF-BETA. The natural origin of this cell type is not clear." + }, + { + "input": "Concept: Loss of Appetite (Findings-Based Question)", + "output": "Intellectual Product described as a question about whether an individual has or had a loss of appetite." + }, + { + "input": "Concept: CCHL1A2 Gene Mutation (Cell or Molecular Dysfunction)", + "output": "something described as a change in the nucleotide sequence of the CACNA1D gene." + }, + { + "input": "Concept: SPL Tissue Form Establishment Functions Terminology (SPL Blood and Tissue Form Terminology)", + "output": "SPL Blood and Tissue Form Terminology described as terminology used to qualify the information pertaining to tissue form establishment functions in the framework of the Structured Product Labeling documents." + }, + { + "input": "Concept: Hemoglobin Casts (Urine Sediment Analysis Measurement)", + "output": "Urine Sediment Analysis Measurement described as a measurement of the hemoglobin casts present in a biological specimen." + }, + { + "input": "Concept: Product containing urea (Amide and amide derivative)", + "output": "Hyperosmotic agent for glaucoma described as a compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids." + }, + { + "input": "Concept: NIDDK (Component of the National Institutes of Health)", + "output": "something described as an institute within the National Institutes of Health that conducts and supports much of the clinical research on the diseases of internal medicine and related subspecialty fields, as well as many basic science disciplines." + }, + { + "input": "Concept: Progressive leg bowing (Progressive bowing of long bones)", + "output": "Progressive bowing of long bones described as progressive bending or abnormal curvature of the leg." + }, + { + "input": "Concept: sensory perception of gravity (Organ or Tissue Function)", + "output": "Organ or Tissue Function described as the series of events required for an organism to receive a gravitational stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." + }, + { + "input": "Concept: Signal Detections, Psychological (Psychophysics)", + "output": "Discrimination described as psychophysical technique that permits the estimation of the bias of the observer as well as detectability of the signal (i.e., stimulus) in any sensory modality." + }, + { + "input": "Concept: TYPEV (Fitzpatrick Classification Scale)", + "output": "Fitzpatrick Classification Scale described as individuals who have dark constitutive pigmentation but become noticeably darker with sun exposure, especially light complected black individuals, those of Indian descent." + }, + { + "input": "Concept: Cardiac revascularization with bypass anastomosis of internal mammary to coronary artery, single vessel (Coronary Artery Bypass Surgery)", + "output": "Therapeutic or Preventive Procedure described as direct myocardial revascularization in which the internal mammary artery is anastomosed to the right coronary artery, circumflex artery, or anterior descending coronary artery. The internal mammary artery is the most frequent choice, especially for a single graft, for coronary artery bypass surgery." + }, + { + "input": "Concept: neutral sphingomyelinase activator (phospholipase activator activity)", + "output": "phospholipase activator activity described as increases the activity of the enzyme sphingomyelin phosphodiesterase." + }, + { + "input": "Concept: Temptation and Restraint Inventory (Intellectual Product)", + "output": "Intellectual Product described as questionnaire designed to test drinking problem" + }, + { + "input": "Concept: PODCI166 (Intellectual Product)", + "output": "PODCI Pediatric Parent-Reported Version Questionnaire Question described as pediatric Outcomes Data Collection Instrument, Pediatric Parent-Reported Version (PODCI Pediatric Parent-Reported Version) How often in the last week did your child participate in gym/recess?" + }, + { + "input": "Concept: organelle degradation (cellular component disassembly)", + "output": "Cell Function described as the disaggregation of an organelle into its constituent components." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, RPS19 (Medical Device)", + "output": "something described as molecular assay reagents intended to identify deletions or duplications of the ribosomal protein S19 (RPS19) gene, located at chromosome 19q13.2, which encodes the protein 40S ribosomal protein S19. Genetic variants at this locus have been associated with Diamond-Blackfan anemia." + }, + { + "input": "Concept: Short Interspersed Nuclear Element (Repetitive Region)", + "output": "Repetitive Region described as highly repeated sequences, 100-300 bases long, which contain RNA polymerase III promoters. The primate Alu (ALU ELEMENTS) and the rodent B1 SINEs are derived from 7SL RNA, the RNA component of the signal recognition particle. Most other SINEs are derived from tRNAs including the MIRs (mammalian-wide interspersed repeats)." + }, + { + "input": "Concept: hip injury (Disorder of hip region)", + "output": "Disorder of pelvis described as damage inflicted on the hip as the direct or indirect result of an external force, with or without disruption of structural continuity." + }, + { + "input": "Concept: BEBQ01-Take a Feed Within 30 Minutes (Intellectual Product)", + "output": "BEBQ Concurrent Version Questionnaire Question described as baby Eating Behaviour Questionnaire Concurrent Version (BEBQ Concurrent Version) My baby can easily take a feed within 30 minutes of the last one." + }, + { + "input": "Concept: ms2 (Quantitative Concept)", + "output": "Unit of time described as a unit of time which is equal to one thousandth of a second squared." + }, + { + "input": "Concept: alcoholism/alcohol abuse prevention (Drug abuse prevention)", + "output": "something described as increasing the awareness of alcoholism or alcohol abuse, prevention of the disease in susceptible individuals or populations through promotion of health, including mental health, and prevention of complications or after-effects of existing disease; this concept may overlap with ALCOHOLISM/ALCOHOL ABUSE EDUCATION." + }, + { + "input": "Concept: Positive urine opioid test (Urine xenobiotic)", + "output": "something described as detection of opioids or opioid metabolites in urine. []" + }, + { + "input": "Concept: Phosphorus Excretion Rate (Quantitative Concept)", + "output": "Excretion Rate described as a measurement of the amount of phosphorus being excreted in a biological specimen over a defined amount of time (e.g. one hour)." + }, + { + "input": "Concept: RPD3L1 Gene Mutation (Gene Mutant)", + "output": "something described as a change in the nucleotide sequence of the HDAC1 gene." + }, + { + "input": "Concept: vitamin biosynthesis (Molecular Function)", + "output": "cellular biosynthetic process described as synthesis of vitamin(s) by living organisms." + }, + { + "input": "Concept: Methylmalonic Aciduria, cblA Type (Disease or Syndrome)", + "output": "something described as an autosomal recessive form of methylmalonic aciduria, caused by mutation(s) in the MMAA gene, encoding MMAA protein." + }, + { + "input": "Concept: Degenerative myopia (Severe myopia)", + "output": "Degenerative disorder described as a sub-type of myopia characterized by high myopia with any posterior myopia-specific pathology resulting from axial elongation." + }, + { + "input": "Concept: tryptophan catabolic process to indoleacetic acid (Molecular Function)", + "output": "Molecular Function described as the chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including indole-3-acetate." + }, + { + "input": "Concept: Receptors, Pattern Recognition (Receptor)", + "output": "Receptor described as a large family of cell surface receptors that bind conserved molecular structures (PAMPS) present in pathogens. They play important roles in host defense by mediating cellular responses to pathogens." + }, + { + "input": "Concept: Hypoplasia of the fifth metatarsal bone (Short metatarsal)", + "output": "Abnormality of the fifth metatarsal bone described as short (hypoplastic) fifth metatarsal bone." + }, + { + "input": "Concept: Abnormal Involuntary Movement Scale Clinical Classification Test Code (CDISC Clinical Classification Terminology)", + "output": "CDISC Clinical Classification Terminology described as test codes of clinical classification questions associated with the Abnormal Involuntary Movement Scale (AIMS) for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: hepatic artery embolization (Embolization of artery)", + "output": "Therapeutic or Preventive Procedure described as a therapeutic procedure involving the injection or deployment of blocking agents in the hepatic artery to treat tumors." + }, + { + "input": "Concept: Element, Response (Enhancer Elements, Genetic)", + "output": "something described as nucleotide sequences, usually upstream, which are recognized by specific regulatory transcription factors, thereby causing gene response to various regulatory agents. These elements may be found in both promoter and enhancer regions." + }, + { + "input": "Concept: MMS103C (Intellectual Product)", + "output": "MMSE Functional Test Question described as mini-Mental State Examination (MMSE) Now repeat those words back to me: Word 3." + }, + { + "input": "Concept: FIQR - Stiffness (FIQR Questionnaire Question)", + "output": "Intellectual Product described as revised Fibromyalgia Impact Questionnaire - Please rate your level of stiffness." + }, + { + "input": "Concept: Influenzas, Avian (Non-human infectious disorder)", + "output": "Bird Diseases described as infection of domestic and wild fowl and other BIRDS with INFLUENZA A VIRUS. Avian influenza usually does not sicken birds, but can be highly pathogenic and fatal in domestic POULTRY." + }, + { + "input": "Concept: regulation of cellular organofluorine metabolic process (Organism Function)", + "output": "Organism Function described as any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells." + }, + { + "input": "Concept: CTCAE Grade 1 Hemolysis (Finding)", + "output": "Finding described as laboratory evidence of hemolysis only" + }, + { + "input": "Concept: Central Tendon of the Diaphragm (Other Embryologic Structure)", + "output": "Tendon structure described as a crescent-shaped, flat aponeurosis composed of dense collagen fibers that forms the intermediate region of the diaphragm, and blends superiorly with the fibrous pericardium." + }, + { + "input": "Concept: threonyl-tRNA aminoacylation (tRNA aminoacylation for protein translation)", + "output": "Genetic Function described as the process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA." + }, + { + "input": "Concept: Resistance, Insulin (Drug resistance)", + "output": "Hyperinsulinism described as decreased sensitivity to circulating insulin which may result in acanthosis nigicrans, elevated insulin level or hyperglycemia." + }, + { + "input": "Concept: microtubule assembly (microtubule polymerization or depolymerization)", + "output": "supramolecular fiber organization described as the addition of tubulin heterodimers to one or both ends of a microtubule." + }, + { + "input": "Concept: HLA-A*0201-restricted VEGFR1-VEGFR2 multipeptide vaccine (Vaccines, Peptide)", + "output": "something described as a cancer vaccine containing two HLA-A*0201-restricted peptide epitopes with potential immunostimulatory and antitumor activities. Peptide epitopes in this vaccine are derived from: vascular endothelial growth factor receptors (VEGFR) 1 and 2. Upon administration, HLA-A*0201-restricted VEGFR1-VEGFR2 multipeptide vaccine may stimulate a cytotoxic T lymphocyte (CTL) response against tumor cells expressing VEGFR 1 and 2 peptides, resulting in tumor cell lysis and decreased tumor growth. HLA-A*0201 is an MHC class I molecule that presents antigenic peptides to CD8+ T cells; epitope design restricted to epitopes that bind most efficiently to HLA-A*0201 may improve antigenic peptide immunogenicity." + }, + { + "input": "Concept: ESS01TC (Intellectual Product)", + "output": "something described as test codes of questionnaire questions associated with the Epworth sleepiness scale questionnaire for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: CS-87 (Nucleic Acid, Nucleoside, or Nucleotide)", + "output": "Pharmacologic Substance described as a dideoxyuridine inhibitor of HIV reverse transcriptase that is related to zidovudine. Navuridine exhibits a relatively short half-life and incomplete oral bioavailability and has not been developed into a clinical drug." + }, + { + "input": "Concept: systemic acquired resistance (Organism Function)", + "output": "Organism Function described as the salicylic acid mediated response to a pathogen which confers broad spectrum resistance." + }, + { + "input": "Concept: cellularization cleavage furrow invagination front (Cell Component)", + "output": "Cell Component described as the base of the cellularization invagination or cleavage furrow most distal to the original multi-nucleate cell or syncytium plasma membrane." + }, + { + "input": "Concept: TPA - Tissue polypeptide antigen (Antigens, Neoplasm)", + "output": "Amino Acid, Peptide, or Protein described as serological tumor marker composed of a molecular complex of cytokeratins 8, 18, and 19. It is used in the diagnosis and staging of bronchogenic carcinoma." + }, + { + "input": "Concept: Relations, Professional-Patient (Delivery of Health Care)", + "output": "something described as interactions between health personnel and patients." + }, + { + "input": "Concept: potentiometry (Laboratory Procedure)", + "output": "Laboratory Procedure described as solution titration in which the end point is read from the electrode-potential variations with the concentrations of potential determining ions." + }, + { + "input": "Concept: Powder for conventional release oral syrup (Powder for Oral Solution)", + "output": "something described as solid preparation consisting of one or more powders, including freeze-dried powders, that may include excipients to facilitate dissolution in water and to obtain the characteristics of a syrup, intended to be dissolved in water to obtain a syrup." + }, + { + "input": "Concept: up-regulation of neuronal signal transduction (positive regulation of signal transduction)", + "output": "positive regulation of signal transduction described as any process that activates or increases the frequency, rate or extent of neuronal signal transduction." + }, + { + "input": "Concept: Wit and Humor as Topic (Attitude)", + "output": "Intellectual Product described as the comical expression of connections between ideas that awaken amusement and pleasure." + }, + { + "input": "Concept: CTPIND (Conceptual Entity)", + "output": "Conceptual Entity described as an indication as to whether there is prolapsing of a cardiac valve chordae tendinae." + }, + { + "input": "Concept: FOOT DIGIT 3 (Body Part, Organ, or Organ Component)", + "output": "something described as the middle or third toe from the medial side of the foot." + }, + { + "input": "Concept: If cM1, specify site(s) (Occupational Activity)", + "output": "Form Directive described as a directive to indicate the anatomic sites if metastasis is categorized as cM1." + }, + { + "input": "Concept: Transversus abdominis (Entire anterolateral muscle of abdomen)", + "output": "Flexor of thoracic intervertebral joint described as an anterolateral muscle of the abdomen which attaches to the thoracolumbar fascia, iliac crest, inguinal ligament, and the costal cartilages of the lower ribs, and which continues anteriorly as the transverse abdominis aponeurosis, which inserts into the linea alba, the pubic crest, and the pectineal line." + }, + { + "input": "Concept: Etoposide/Prednisone/Vinblastine (Agent Combination Not Indexed in Open Clinical Trials)", + "output": "Agent Combination Not Indexed in Open Clinical Trials described as a combination of agents containing etoposide, prednisone and vinblastine." + }, + { + "input": "Concept: Breast Carcinoma pN0 TNM Finding v7 (Breast Cancer Pathologic Regional Lymph Nodes TNM Finding v7)", + "output": "Finding described as breast cancer without histological evidence of regional lymph node involvement. Lymph nodes containing only isolated tumor cell clusters are excluded from the total positive node count for purposes of regional lymph node classification, but should be included in the total number of nodes evaluated." + }, + { + "input": "Concept: SEND Respiratory Test Name (CDISC SEND Terminology)", + "output": "Intellectual Product described as terminology related to the non-clinical respiratory test name codelist." + }, + { + "input": "Concept: Voxel Size (size)", + "output": "something described as the three distances on the imaged subject that correspond to the width, height, and depth of the smallest piece of the subject that is displayed as a voxel." + }, + { + "input": "Concept: Clinical Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8 (Neoplastic Process)", + "output": "something described as stage IVB includes: Any T, Any N, M1. M1: Distant metastasis." + }, + { + "input": "Concept: Gastric Adenomatous Polyp (Gastric adenoma)", + "output": "Benign neoplasm of stomach described as a neoplastic polyp that arises from the stomach. It is associated with intestinal-type differentiation. The presence of high grade dysplasia and a size of more than 2 cm are factors that increase the risk of malignant transformation." + }, + { + "input": "Concept: regulation of morphogenetic apoptosis (regulation of anatomical structure morphogenesis)", + "output": "something described as any process that modulates the frequency, rate or extent of apoptotic process involved in morphogenesis." + }, + { + "input": "Concept: Norepinephrine Secreting (Finding)", + "output": "something described as a finding indicating that an excess amount of norepinephrine is secreted by a tumor." + }, + { + "input": "Concept: specific immune cell (Lymphocyte)", + "output": "something described as a white blood cell that, after being in contact with an antigen, rearranges its DNA to defend against that one specific type of antigen. After activation, it can then proliferate and differentiate into memory cells, antibody-secreting cells or plasma cells." + }, + { + "input": "Concept: Elevated hepatic transaminase (Abnormal liver morphology)", + "output": "LABORATORY ABNORMALITIES described as elevations of the levels of SGOT and SGPT in the serum. SGOT (serum glutamic oxaloacetic transaminase) and SGPT (serum glutamic pyruvic transaminase) are transaminases primarily found in the liver and heart and are released into the bloodstream as the result of liver or heart damage. SGOT and SGPT are used clinically mainly as markers of liver damage." + }, + { + "input": "Concept: FGF-3 Gene Mutation (Cell or Molecular Dysfunction)", + "output": "something described as a change in the nucleotide sequence of the FGF3 gene." + }, + { + "input": "Concept: HRH-J8 protein, human (RNA Helicase)", + "output": "Amino Acid, Peptide, or Protein described as probable ATP-dependent RNA helicase DDX10 (875 aa, ~101 kDa) is encoded by the human DDX10 gene. This protein plays a role in the ATP-dependent unwinding of helical RNA." + }, + { + "input": "Concept: pathologist (RoleCode)", + "output": "RoleCode described as a doctor who identifies diseases by studying cells and tissues under a microscope." + }, + { + "input": "Concept: thiopurine S-methyltransferase (Methyltransferase Gene)", + "output": "something described as this gene plays a role in the metabolism of thiopurine drugs." + }, + { + "input": "Concept: HLA-A*2402-Restricted URLC10 Peptides Vaccine (Vaccines, Peptide)", + "output": "Amino Acid, Peptide, or Protein described as a cancer vaccine containing HLA-A*2402-restricted epitope peptides URLC10 (up-regulated lung cancer 10) with potential immunostimulatory and antineoplastic activities. Upon administration, HLA-A*2402-restricted URLC10 peptides vaccine may stimulate a cytotoxic T lymphocyte (CTL) response against URLC10-expressing tumor cells. URLC10, a tumor associated antigen, is often overexpressed in lung, esophageal and gastric cancers. HLA-A*2402 is an MHC class I molecule that presents antigenic peptides to CD8+ T cells; epitope design restricted to epitopes that bind most efficiently to HLA-A*2402 may improve antigenic peptide immunogenicity." + }, + { + "input": "Concept: 9: 87570534-87575862 (Spatial Concept)", + "output": "something described as physical location of CTSL_Gene" + }, + { + "input": "Concept: Gram Positive Bacteria (Laboratory Procedure)", + "output": "Laboratory Procedure described as a measurement of the gram positive bacteria in a biological specimen." + }, + { + "input": "Concept: gallate 1-b-glucosyltransferase activity (phenol beta-glucosyltransferase activity)", + "output": "something described as catalysis of the reaction: gallate + UDP-D-glucose = 1-O-galloyl-beta-D-glucose + UDP." + }, + { + "input": "Concept: Hypopigmentation of skin, NOS (Pigmentary Change in Skin)", + "output": "something described as abnormal lightening of skin due to decreased melanin production or deposition. Vitiligo, albinism, and leukoderma are among the disorders that are associated with skin hypopigmentation." + }, + { + "input": "Concept: Neurorehabilitation (Rehabilitation therapy)", + "output": "Rehabilitation therapy described as physician-supervised programs designed to rehabilitate people with diseases, trauma, or disorders of the NERVOUS SYSTEM." + }, + { + "input": "Concept: Binder (Pharmaceutical Excipient)", + "output": "something described as a substance that makes a loose mixture stick together. For example, binding agents can be used to make solid pills from loose powders." + }, + { + "input": "Concept: phantom pain (Peripheral Nervous System Diseases)", + "output": "Pain described as pain felt as if it were arising in an absent or amputated limb, organ or body part." + }, + { + "input": "Concept: of mouth mucosa (Oral cavity)", + "output": "Upper aerodigestive tract described as the mucosal membranes that line the oral cavity." + }, + { + "input": "Concept: Product containing halothane (General anesthetic drugs)", + "output": "Pharmacologic Substance described as a nonflammable, halogenated, hydrocarbon and general inhalation anesthetic. Although the exact mechanism of action is unknown, halothane provides relatively rapid induction of anesthesia by depressing the central nervous system, thereby producing a reversible loss of consciousness and sensation." + }, + { + "input": "Concept: Fe-NA chelate transporter activity (iron chelate transmembrane transporter activity)", + "output": "Molecular Function described as enables the transfer of the iron chelate iron-nicotianamine (Fe-NA) from one side of a membrane to the other." + }, + { + "input": "Concept: Precipitate (Physical Object)", + "output": "Specimen described as the solid that can be caused to settle out of a solution." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, SCN5A (Medical Device)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication described as molecular assay reagents intended to identify deletions or duplications of the sodium voltage-gated channel alpha subunit 5 (SCN5A) gene, located at chromosome 3p22.2, which encodes the protein sodium channel protein type 5 subunit alpha. Genetic variants at this locus have been associated with Brugada syndrome, dilated cardiomyopathy, familial atrial fibrillation, long QT syndrome, paroxysmal familial ventricular fibrillation, progressive familial heart block, sick sinus syndrome, and sudden infant death syndrome." + }, + { + "input": "Concept: Fat adherence syndrome (Eye and ear procedural complications)", + "output": "something described as violation of Tenon's capsule with prolapse of orbital fat into the sub-Tenon's space." + }, + { + "input": "Concept: PODCI Adolescent Self-Reported Version - Competitive Sports Limited by: Instructions (PODCI Adolescent Self-Reported Version Questionnaire Question)", + "output": "something described as pediatric Outcomes Data Collection Instrument, Adolescent Self-Reported Version (PODCI Adolescent Self-Reported Version) If you answered \"no\" to Question 50 above, was your activity limited by: Doctor or parent instructions?" + }, + { + "input": "Concept: posterior mitral leaflet (Entire leaflet of mitral valve)", + "output": "Structure of anulus fibrosus of mitral orifice described as leaflet of mitral valve which is attached to the posterior head of the lateral papillary muscle of left ventricle through the chorda tendinea of the left ventricle." + }, + { + "input": "Concept: negative regulation of activated T cell autonomous cell death (Cell Function)", + "output": "Cell Function described as any process that stops, prevents, or reduces the frequency, rate or extent of activated T cell autonomous cell death." + }, + { + "input": "Concept: Molar tooth structure (Molar tooth)", + "output": "something described as the most posterior teeth on either side of the jaw, totaling eight in the deciduous dentition (2 on each side, upper and lower), and usually 12 in the permanent dentition (three on each side, upper and lower). They are grinding teeth, having large crowns and broad chewing surfaces." + }, + { + "input": "Concept: mesenchymal to epithelial transition involved in mesonephros morphogenesis (mesenchymal to epithelial transition)", + "output": "mesenchymal to epithelial transition described as a transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the mesonephros." + }, + { + "input": "Concept: Serine O Acetyltransferase (Amino Acid, Peptide, or Protein)", + "output": "Acetyltransferase described as an enzyme that catalyzes the conversion of L-SERINE to COENZYME A and O-acetyl-L-serine, using ACETYL-COA as a donor." + }, + { + "input": "Concept: Autosomal recessive hyperinsulinemic hypoglycaemia due to Kir6.2 deficiency (Hyperinsulinism)", + "output": "Hyperinsulinism described as a rare congenital isolated hyperinsulinism disorder with characteristics of neonatal presentation of severe refractory hypoglycemia in the first two days of life with limited response to medical management sometimes requiring pancreatic resection. Newborns are often large for gestational age with mild to moderate hepatomegaly and diffuse form of hyperinsulinism due to Kir6.2 deficiency. Persistent hypoglycemia, hyperglycemia and type 1 diabetes mellitus may develop later in life. Life-threatening hypoglycemic coma or status epilepticus have also been associated. Caused by mutation in the gene encoding the Kir6.2 subunit of the inwardly rectifying potassium channel (KCNJ11)." + }, + { + "input": "Concept: Vitamin C in Brain Pathway (Cell Function)", + "output": "something described as vitamin C (ascorbic acid) was first identified by virtue of the essential role it plays in collagen modification, preventing the nutritional deficiency scurvy. Vitamin C acts as a cofactor for hydroxylase enzymes that post-translationally modify collagen to increase the strength and elasticity of tissues. Vitamin C reduces the metal ion prosthetic groups of many enzymes, maintaining activity of enzymes, and also acts as an anti-oxidant. Although the prevention of scurvy through modification of collagen may be the most obvious role for vitamin C, it is not necessarily the only role of vitamin C. Svct1 and Svct2 are ascorbate transporters for vitamin C import into tissues and into cells. Both of these transporters specifically transport reduced L-ascorbic acid against a concentration gradient using the intracellular sodium gradient to drive ascorbate transport. Svct1 is expressed in epithelial cells in the intestine, upregulated in cellular models for intestinal epithelium and appears to be responsible for the import of dietary vitamin C from the intestinal lumen. The vitamin C imported from the intestine is present in plasma at approximately 50 uM, almost exclusively in the reduced form, and is transported to tissues to play a variety of roles. Svct2 imports reduced ascorbate from the plasma into very active tissues like the brain. Deletion in mice of the gene for Svct2 revealed that ascorbate is required for normal development of the lungs and brain during pregnancy. A high concentration of vitamin C in neurons of the developing brain may help protect the developing brain from free radical damage. The oxidized form of ascorbate, dehydroascorbic acid, is transported into a variety of cells by the glucose transporter Glut-1. Glut-1, Glut-3, and Glut-4 can transport dehydroascorbate, but may not transport significant quantities of ascorbic acid in vivo." + }, + { + "input": "Concept: Healthy Subjects (Research Subject)", + "output": "Human Study Subject described as a healthy person volunteering to participate as a subject in a clinical study. NOTE: This is often a healthy person agreeing to participate in a Phase 1 trial. See also Phase 1." + }, + { + "input": "Concept: induction of autolysin activity in other organism (positive regulation of catalytic activity in other organism involved in symbiotic interaction)", + "output": "something described as any process in which an organism initiates the activity of the inactive enzyme autolysin in another organism. The autolysin enzyme belongs to, and is active in, the other organism." + }, + { + "input": "Concept: BIFIDOBACTERIUM BREVE (B [Preparations])", + "output": "Bifidobacterium described as a bacterial species in the family Bifidobacteriaceae. B. breve ferments alpha-l-fucose but does not ferment D-blucuronate, arabinogalactan, xylan, porcine gastric mucin, or gums. This bacteria is a normal part of the gut flora and is frequently used as a probiotic." + }, + { + "input": "Concept: Spurs, Bone (Osteophyte)", + "output": "Exostoses described as a bony projection that forms on the joints of the body." + }, + { + "input": "Concept: Childhood Papillary Thyroid Carcinoma (Neoplastic Process)", + "output": "something described as a papillary thyroid carcinoma occurring during childhood. The RET/PTC gene rearrangements are more common in children than adults." + }, + { + "input": "Concept: Histrelin Acetate (Luteinizing Hormone-releasing Hormone Agonist)", + "output": "acetate described as the acetate salt form of histrelin, a long-acting, synthetic nonapeptide analog of gonadotropin-releasing hormone (GnRH) with potential anti-tumor activity. Upon administration, histrelin binds to and activates GnRH receptors; prolonged administration results in pituitary GnRH receptor desensitization and inhibition of follicle stimulating hormone (FSH) and luteinizing hormone (LH) secretion, leading to a significant decline in testosterone production in males and may inhibit androgen receptor-positive tumor progression; in females, prolonged administration results in decreased estradiol production. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C77424\" active clinical trials using this agent." + }, + { + "input": "Concept: LIM Homeobox Transcription Factor 1 Beta (TRANSCRIPTION FACTOR)", + "output": "Amino Acid, Peptide, or Protein described as LIM homeobox transcription factor 1 beta (379 aa, ~42 kDa) is encoded by the human LMX1B gene. This protein plays a role in limb development and transcription." + }, + { + "input": "Concept: EWINGELLA AMERICANA (Ewingella)", + "output": "something described as a species of facultatively anaerobic, Gram negative, rod shaped bacterium assigned to the phylum Proteobacteria. This species is oxidase negative, fermentative, susceptible to ampicillin, amoxicillin-clavulanate, ceftazidime, ceftriaxone, cefotaxime, cefepime, ofloxacin, gentamicin, carbenicillin, and amikacin but resistant to cephalothin, penicillin G, and vancomycin. A rare human pathogen, it can be isolated from human blood, stool, urine, wounds, conjunctiva, respiratory tract, and peritoneal dialysate of immunocompromised patients." + }, + { + "input": "Concept: NURF (Amino Acid, Peptide, or Protein)", + "output": "something described as the Drosophila NURF complex catalyzes nucleosome sliding. The Nurf301 subunit contains a bromodomain transcription factor domain, a zinc finger binding domain, nuclear localization signals, and motifs associated with rapid protein degradation. The HMGA/HMGI(Y)-like domain of Nurf301 facilitates nucleosome sliding. Nurf301 also interacts with sequence-specific transcription factors, providing a basis for targeted recruitment of the NURF complex to specific genes." + }, + { + "input": "Concept: Science of neurochemistry (Neuroscience discipline)", + "output": "Neurosciences described as a branch of neurology concerned with the chemistry of the nervous system." + }, + { + "input": "Concept: RAD/ZD 1839 (Agent Combination Not Indexed in Open Clinical Trials)", + "output": "Agent Combination Not Indexed in Open Clinical Trials described as a chemotherapy drug combination consisting of everolimus and gefitinib. Everolimus is a proliferation inhibitor with immunosuppressive and anti-angiogenic properties. Gefitinib is an epidermal growth factor receptor (EGFR) inhibitor with anti-angiogenic activity. This combination chemotherapy may result in increased tumor cell death compared to the use of either agent alone." + }, + { + "input": "Concept: Phosphoserine Domain (Amino Acid Sequence)", + "output": "something described as a protein motif containing a phosphorylated serine residue. These motifs can influence both protein-protein interactions and cellular signaling." + }, + { + "input": "Concept: sepiapterin deaminase activity (deaminase activity)", + "output": "something described as catalysis of the reaction: sepiapterin + H2O = xanthopterin-B2 + NH3." + }, + { + "input": "Concept: regulation of extent of heterochromatin formation (regulation of heterochromatin assembly)", + "output": "something described as any process that modulates the extent or location of heterochromatin formation." + }, + { + "input": "Concept: Influenza B Antigen Measurement (Laboratory Procedure)", + "output": "something described as a measurement of the influenza B antigen in a biological specimen." + }, + { + "input": "Concept: ZIM2 Gene (Gene or Genome)", + "output": "something described as this gene may play a role in transcriptional regulation." + }, + { + "input": "Concept: regulation of glutamate metabolic process (Molecular Function)", + "output": "regulation of glutamine family amino acid metabolic process described as any process that modulates the frequency, rate or extent of glutamate metabolic process." + }, + { + "input": "Concept: MIVEBRESIB (Pharmacologic Substance)", + "output": "Antineoplastic Agents described as an inhibitor of one or more as of yet undisclosed bromodomain (BRD)-containing protein(s), with potential antineoplastic activity. Upon administration, mivebresib binds to the acetyl-lysine binding site in the BRD of certain BRD-containing protein(s), thereby preventing the interaction between those proteins and acetylated histones. This disrupts chromatin remodeling, prevents the expression of certain growth-promoting genes, and leads to an inhibition of cell growth in susceptible tumors." + }, + { + "input": "Concept: Molecular Structure, 3D (Molecular Structure)", + "output": "something described as the characteristic three-dimensional shape of a molecule." + }, + { + "input": "Concept: dehydrogenase (Amino Acid, Peptide, or Protein)", + "output": "Substance categorized by disposition described as catalyses oxidation/reduction reactions." + }, + { + "input": "Concept: pancreatic islet neoplasm (Pancreatic Neoplasm)", + "output": "Neoplastic Process described as new abnormal pancreatic islet cells that grow by excessive cellular division and proliferation more rapidly than normal and continue to grow after the stimuli that initiated the new growth cease." + }, + { + "input": "Concept: GH Cells, Pituitary (Acidophil cell)", + "output": "Acidophil cell of pars distalis of adenohypophysis described as anterior pituitary cells which produce GROWTH HORMONE." + }, + { + "input": "Concept: GBF bZIP Transcription Factor (DNA-Binding Proteins)", + "output": "TRANSCRIPTION FACTOR described as a large superfamily of transcription factors that contain a region rich in BASIC AMINO ACID residues followed by a LEUCINE ZIPPER domain." + }, + { + "input": "Concept: Movement (Organism Function)", + "output": "CHAPTER 7 NEUROMUSCULOSKELETAL AND MOVEMENT-RELATED FUNCTIONS described as see:http://www.nlm.nih.gov/mesh/MBrowser.html" + }, + { + "input": "Concept: Volume of Distribution Predicted Normalized by Weight (Quantitative Concept)", + "output": "something described as the predicted volume of distribution associated with the terminal slope following intravascular administration divided by the weight." + }, + { + "input": "Concept: DYS (Dysautonomia)", + "output": "Congenital neurologic anomalies described as autosomal disorder of the peripheral and autonomic nervous systems limited to individuals of Ashkenazic Jewish descent; clinical manifestations are present at birth and include diminished lacrimation, defective thermoregulation, orthostatic hypotension, fixed pupils, excessive sweating, loss of pain and temperature sensation, and absent reflexes; pathologic features include reduced numbers of small diameter peripheral nerve fibers and autonomic ganglion neurons." + }, + { + "input": "Concept: Pulmonary Valve Regurgitant Volume (Quantitative Concept)", + "output": "Quantitative Concept described as a measurement of the volume of retrograde blood flow across the orifice of the pulmonic valve." + }, + { + "input": "Concept: SYK Tyrosine Kinase (Protein Tyrosine Kinase)", + "output": "something described as an SH2 domain-containing non-receptor tyrosine kinase that regulates signal transduction downstream of a variety of receptors including B-CELL ANTIGEN RECEPTORS. It functions in both INNATE IMMUNITY and ADAPTIVE IMMUNITY and also mediates signaling in CELL ADHESION; OSTEOGENESIS; PLATELET ACTIVATION; and vascular development." + }, + { + "input": "Concept: 17: 29714365-29711512 (Spatial Concept)", + "output": "something described as physical location of CCL1_Gene" + }, + { + "input": "Concept: V-Myb Avian Myeloblastosis Viral Oncogene Homolog-Like 1 Gene (MYBL1 gene)", + "output": "something described as human MYBL1 wild-type allele is located in the vicinity of 8q22 and is approximately 51 kb in length. This allele, which encodes myb-related protein A, is involved in the regulation of transcription by RNA polymerase II as well as proliferation and differentiation of neurogenic, spermatogenic and B-lymphoid cells." + }, + { + "input": "Concept: Bacterial Vaginosis Screening (Pregnancy Related Screening Test)", + "output": "Pregnancy Related Screening Test described as a test done during pregnancy for the presence of Gardnerella vaginalis, Ureaplasma urealyticum, Mycoplasma hominis, Mobiluncus, Prevotella and anaerobic bacteria." + }, + { + "input": "Concept: CHESON NON-HODGKINS HODGKINS LYMPHOMA 1993 (Tumor Response Criterion)", + "output": "Tumor Response Criterion described as inflammatory breast cancer. Pilot study of intensive induction chemotherapy (FEC-HD) results in a high histologic response rate. (Chevallier B, Roche H, Olivier JP, Chollet P, Hurteloup P. Inflammatory breast cancer. Pilot study of intensive induction chemotherapy (FEC-HD) results in a high histologic response rate. Am J Clin Oncol. 1993 Jun;16(3):223-8.)" + }, + { + "input": "Concept: Stage II Thyroid Gland Follicular Carcinoma AJCC v8 (Neoplastic Process)", + "output": "Neoplastic Process described as stage II includes: Under 55 years: Any T, Any N, M1; 55 years and older: (T1, N1, M0); (T2, N1, M0); (T3a/T3b, Any N, M0). T1: Tumor measuring 2 cm or less in greatest dimension limited to the thyroid. T2: Tumor measuring more than 2 cm but 4 cm or less in greatest dimension limited to the thyroid. T3a: Tumor measuring more than 4 cm in greatest dimension limited to the thyroid. T3b: Gross extrathyroidal extension invading only strap muscles (sternohyoid, sternothyroid, thyrohyoid, or omohyoid muscles) from a tumor of any size. N1: Metastasis to regional nodes. M0: No distant metastasis. M1: Distant metastasis." + }, + { + "input": "Concept: FAC016-I Feel Sad (Intellectual Product)", + "output": "FACT-L Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Lung Version 4 (FACT-L Version 4) Emotional Well-Being: I feel sad." + }, + { + "input": "Concept: Lead compound (Lead and lead compound)", + "output": "inorganic lead described as an inorganic or organic substance that contains the metallic element lead either in its positive-2 or 4 valence state. Lead compounds have a wide variety of applications in industry. Exposure to lead compounds affects the lungs, central nervous system and kidneys. Lead compounds are possible mutagens and are reasonably anticipated to be human carcinogens. The substance may be associated with an increased risk of developing lung and stomach cancer." + }, + { + "input": "Concept: Fall prevention behaviour (Risk control behavior)", + "output": "Safety described as personal or family caregiver actions to minimize risk factors that might precipitate falls in the personal environment" + }, + { + "input": "Concept: Amino Acid Ratio Measurement (Amino acids measurement)", + "output": "something described as the determination of the ratio of one amino acid compared to another amino acid present in a sample. The measurement may be expressed as a ratio or percentage." + }, + { + "input": "Concept: Pyometras (Body of uterus finding)", + "output": "Female infertility described as the accumulation of inflammatory cells, predominantly neutrophils, within the uterus and lumen." + }, + { + "input": "Concept: Study Agent Pediatric Formulation Indicator (Functional Concept)", + "output": "something described as specifies whether the pharmaceutical form of the agent is intended for pediatric usage. EXAMPLE(S): A value of true may indicate that the agent is dissolvable, smaller, or grape flavored to be easily ingested by the pediatric population. OTHER NAME(S): NOTE(S):" + }, + { + "input": "Concept: negative regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine (regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine)", + "output": "negative regulation of lysine biosynthetic process via aminoadipic acid described as any process that stops, prevents or reduces the frequency, rate or extent of lysine biosynthetic process via alpha-aminoadipate and saccharopine." + }, + { + "input": "Concept: Dose Regimen (Therapeutic or Preventive Procedure)", + "output": "Therapeutic or Preventive Procedure described as the planned schedule for the administration of an agent (such as a drug, substance or radiation)." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, FKRP (Medical Device)", + "output": "something described as molecular assay reagents intended to identify mutations in the fukutin-related protein (FKRP) gene, located at chromosome 19q13.3, which possibly encodes for a transferase involved in the modification of glycan moieties of alpha-dystroglycan (DAG-1). Mutations at this locus have been identified in patients with early-onset (neonatal) congenital muscular dystrophy type 1C (MDC1C) and type 21 (LDMG21)." + }, + { + "input": "Concept: Dental Attachments (Dental Equipment and Supplies)", + "output": "Medical Device described as devices designed to attach the plate (i.e., base) of a removable partial denture (including overlay dentures) to a fixed support (abutment) such as a natural tooth, tooth-root, dental implant, abutment crown, or tooth root stud. Dental attachments may consist of either a single, integral component: a preformed or custom-made metal casting or wire that fits around neighboring natural teeth to support a denture (i.e., clasps); or two components: one component is attached to the prosthesis and a second receptacle is attached to or anchored within a remaining tooth or other type of abutment (i.e., precision or semiprecision attachments, respectively). Both precision and semiprecision attachments may be resilient or rigid (i.e., nonresilient); dedicated attachments intended for partial dentures and overlay partial dentures (i.e., overdentures) are available. Dental attachments intended for fixed partial dental prostheses (i.e., bridges) are usually cemented in place to natural teeth." + }, + { + "input": "Concept: care for myself (Intellectual Product)", + "output": "something described as a question about the ability of an individual to care for themself." + }, + { + "input": "Concept: ENOS Enzyme (Enzyme)", + "output": "Nitric Oxide Synthase described as a CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS." + }, + { + "input": "Concept: Presequence Protease, Mitochondrial (Metalloproteases)", + "output": "Enzyme described as presequence protease, mitochondrial (1037 aa, ~117 kDa) is encoded by the human PITRM1 gene. This protein is involved in the catabolism of mitochondrial peptides." + }, + { + "input": "Concept: Mitogens (Pharmacologic Substance)", + "output": "Physiology-Regulatory Factor described as any of a class of substances that stimulate mitosis and cell transformation, especially lymphocyte transformation." + }, + { + "input": "Concept: SNORD50A (Small Nucleolar RNA)", + "output": "Small Nucleolar RNA described as u50 small nucleolar RNA (75 bases) is encoded by the human SNORD50A gene. This oligoribonucleotide plays a role in the methylation of ribose in preribosomal RNA." + }, + { + "input": "Concept: Falciform ligament (Mesentery)", + "output": "Liver described as a fold of tissue consisting of two layers of peritoneum extending from the notch of the anterior margin of the liver to the anterior abdominal wall and diaphragm." + }, + { + "input": "Concept: testicular choriocarcinoma and seminoma (Neoplastic Process)", + "output": "cellular diagnosis, testicular cancer described as a malignant germ cell tumor arising from the testis. It is characterized by a mixture of choriocarcinoma and seminomatous morphologic elements. Patients may present with painless or painful testicular swelling. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C9173\" active clinical trials using this agent." + }, + { + "input": "Concept: Duodenum and Ampulla of Vater Neuroendocrine Tumor cM1b TNM Finding v8 (Duodenum and Ampulla of Vater Neuroendocrine Tumor cM1 TNM Finding v8)", + "output": "Finding described as duodenum and ampulla of Vater neuroendocrine tumor with metastasis in at least one extrahepatic site (e.g., lung, ovary, nonregional lymph node, peritoneum, bone)." + }, + { + "input": "Concept: Power Fluctuation (Device Evaluation Result)", + "output": "Device Evaluation Result described as the device failed due to fluctuations within the power supply (e.g. transient power, power spike, power dip, or power sequencing)." + }, + { + "input": "Concept: Administration of antineoplastic agent (Chemotherapy)", + "output": "Therapeutic or Preventive Procedure described as the treatment of disease using chemical agents or drugs that are selectively toxic to the causative agent of the disease, such as a virus, bacterium, or other microorganism." + }, + { + "input": "Concept: Smoking (Individual Behavior)", + "output": "Personal Behavior described as the act of puffing and/or inhaling the combustion products of a substance so as to be tasted and absorbed into the bloodstream." + }, + { + "input": "Concept: Woolly scalp hair (Head)", + "output": "Woolly hair described as the presence of woolly hair on the scalp. The term woolly hair refers to an abnormal variant of hair that is fine, with tightly coiled curls, and often hypopigmented. Optical microscopy may reveal the presence of tight spirals and a clear diameter reduction as compared with normal hair. Electron microscopy may show flat, oval hair shafts with reduced transversal diameter." + }, + { + "input": "Concept: FERUMOXSIL 175MCG/ML (IRON) SUSP,ORAL (Product manufactured as oral dose form)", + "output": "ferumoxsil described as an orally administered aqueous suspension of silicone-coated, superparamagnetic iron oxide used as a magnetic resonance imaging (MRI) contrast agent. After oral administration, ferumoxsil fills the stomach and intestines. Upon exposure to the strong external magnetic field during MRI, ferumoxsil exhibits strong T1 relaxation properties and a strongly varying local magnetic field; T2 relaxation is enhanced, thereby darkening the contrast agent-containing portion of the gastrointestinal tract. Delineation of the bowel is thus enhanced, distinguishing bowel from organs and tissues adjacent to the upper regions of the gastrointestinal tract." + }, + { + "input": "Concept: CARTOX No Neurological Impairment (Intellectual Product)", + "output": "CARTOX 10 Point Neurological Assessment described as a score of 10 on the CARTOX-10 assessment, indicating no neurotoxicity." + }, + { + "input": "Concept: Gamma-Distribution (Quantitative Concept)", + "output": "Quantitative Concept described as a two-parameter family of continuous probability distributions, with a scale parameter theta and a shape parameter k." + }, + { + "input": "Concept: Transurethral use (Genito-urinary route)", + "output": "Drug Administration Routes described as a urethral route that begins through the urethra." + }, + { + "input": "Concept: HLA Match 6/10 (HLA Mismatch)", + "output": "something described as degree of HLA match is 6/10 for HLA-A, -B, -C, -DRB1, and -DQB1 loci." + }, + { + "input": "Concept: 1-18:2-2-18:1-phosphatidylcholine desaturase activity (oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water)", + "output": "something described as catalysis of the reaction: 1-18:2-2-18:1-phosphatidylcholine + O2 + a reduced electron acceptor = 1-18:2-2-18:2-sn-glycerol-3-phosphocholine + 2 H2O + an oxidized electron acceptor." + }, + { + "input": "Concept: Merkel Cell Carcinoma cM1b TNM Finding v8 (Finding)", + "output": "something described as merkel cell carcinoma with metastasis to lung." + }, + { + "input": "Concept: Laurus L., 1753 (Lauraceae)", + "output": "Lauraceae described as a plant genus in the LAURACEAE family. Laurus nobilis L. leaves are known for use in SPICES, having a similar flavor as UMBELLULARIA." + }, + { + "input": "Concept: Fistula;rectal (Rectal examination)", + "output": "Fissure and fistula of anal and rectal regions described as the presence of a fistula affecting the rectum." + }, + { + "input": "Concept: Was BRAF Mutation Analysis Performed (Intellectual Product)", + "output": "Was Molecular Analysis Performed described as a question asking if BRAF mutations were analyzed during the study." + }, + { + "input": "Concept: 1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide (Azoles)", + "output": "Anti-Infective Agents described as 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamid e; antiretroviral agent with potential efficacy against AIDS." + }, + { + "input": "Concept: Non-Esterified Fatty Acid, Free (Laboratory Procedure)", + "output": "Fatty acid measurement described as a measurement of the total non-esterified fatty acids in a biological specimen." + }, + { + "input": "Concept: response to capsazepine (response to organic cyclic compound)", + "output": "response to organonitrogen compound described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a capsazepine stimulus." + }, + { + "input": "Concept: L-2-Amino-3-[(N-nitroso)hydroxylamino]propionic acid (Adenylosuccinate Synthetase Inhibitor)", + "output": "something described as an amino acid analogue and antibiotic derived from the bacterium Streptomyces alanosinicus with antimetabolite and potential antineoplastic activities. L-alanosine inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate, an intermediate in purine metabolism. L-alanosine-induced disruption of de novo purine biosynthesis is potentiated by methylthioadenosine phosphorylase (MTAP) deficiency. The clinical use of this agent may be limited by its toxicity profile. MTAP is a key enzyme in the adenine and methionine salvage pathways." + }, + { + "input": "Concept: Hyperbilirubinaemia neonatal (Disease or Syndrome)", + "output": "Neonatal disorder described as accumulation of BILIRUBIN, a breakdown product of HEME PROTEINS, in the BLOOD during the first weeks of life. This may lead to NEONATAL JAUNDICE. The excess bilirubin may exist in the unconjugated (indirect) or the conjugated (direct) form. The condition may be self-limiting (PHYSIOLOGICAL NEONATAL JAUNDICE) or pathological with toxic levels of bilirubin." + }, + { + "input": "Concept: Grade 2 Phantom pain (Finding)", + "output": "something described as moderate pain; limiting instrumental ADL" + }, + { + "input": "Concept: Hexadecanoic acid (Fatty Acids)", + "output": "Saturated fat described as a common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Serology, Fungi/Yeast, Candida albicans (IVD Test Reagent/Kits, Serology, Fungi/Yeast, Candida Species)", + "output": "IVD Test Reagent/Kits, Serology, Fungi/Yeast, Candida Species described as serology reagents intended to detect serum antibody titers or antigens to Candida albicans, a yeast-like species of imperfect fungi of the family Cryptococcaceae. These fungi are part of the normal flora of the skin, mouth, intestinal tract, and vagina; they can cause superficial infection of the moist cutaneous areas of the body. The fungi may also infect the blood stream (i.e., deep candidiasis), frequently in immunocompromised patients." + }, + { + "input": "Concept: negative regulation of ureidospore formation (negative regulation of asexual sporulation resulting in formation of a cellular spore)", + "output": "regulation of uredospore formation described as any process that stops, prevents, or reduces the frequency, rate or extent of uredospore formation, a process in which an asexual, dikaryotic, often rusty-colored spore, is formed in a structure called a uredinium." + }, + { + "input": "Concept: Liposarcoma, Dedifferentiated (Malignant musculoskeletal and connective tissue neoplasms)", + "output": "something described as an atypical lipomatous tumor/well differentiated liposarcoma that shows progression to a usually non-lipomatous, high grade sarcoma. The non-lipomatous sarcoma component may be present in the primary lesion or at the site of recurrence." + }, + { + "input": "Concept: acute cholecystitis (Gallbladder Infection)", + "output": "Disease or Syndrome described as acute inflammation of the GALLBLADDER wall. It is characterized by the presence of ABDOMINAL PAIN; FEVER; and LEUKOCYTOSIS. Gallstone obstruction of the CYSTIC DUCT is present in approximately 90% of the cases." + }, + { + "input": "Concept: Golden Rod Extract (Organic Chemical)", + "output": "something described as a group of North American weedy herbs belonging to the genus Solidago (family Asteraceae) with potential chemopreventive activities. Goldenrod may also possess anti-inflammatory, antiseptic properties, diuretic and antifungal properties, and may relieve chemotherapy-induced side-effects. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C52191\" active clinical trials using this agent." + }, + { + "input": "Concept: up regulation of hemiterpene biosynthetic process (positive regulation of olefin biosynthetic process)", + "output": "positive regulation of isoprene metabolic process described as any process that activates or increases the frequency, rate or extent of isoprene biosynthetic process." + }, + { + "input": "Concept: Truncated GLI1 Gene (Gene or Genome)", + "output": "GLI1 gene described as human tGLI1 allele is located in the vicinity of 12q13.3 and is approximately 12 kb in length. This allele, which encodes truncated glioma-associated oncogene homolog 1 protein, is involved in the modulation of transcription by RNA polymerase II. Expression of this allele is associated with glioblastoma multiforme (GBM)." + }, + { + "input": "Concept: Major Salivary Gland Carcinoma pN3b TNM Finding v8 (Finding)", + "output": "Major Salivary Gland Cancer pN3 TNM Finding v8 described as major salivary gland cancer with metastasis in a single ipsilateral node larger than 3 cm in greatest dimension and ENE(+); or multiple ipsilateral, contralateral, or bilateral nodes any with ENE(+)." + }, + { + "input": "Concept: thymidylate synthase (Amino Acid, Peptide, or Protein)", + "output": "something described as a protein involved in making and repairing DNA (molecules inside cells that carry genetic information and pass it on from parent to child). High levels of thymidylate synthase may be involved in how certain types of cancer form and respond to treatment." + }, + { + "input": "Concept: SMAD, Mothers Against DPP Homolog 6 Gene (Gene or Genome)", + "output": "SMAD6 gene described as human SMAD6 wild-type allele is located within 15q21-q22 and is approximately 80 kb in length. This allele, which encodes mothers against decapentaplegic homolog 6 protein, plays a role in the regulation of both heart and blood vessel development and maintenance." + }, + { + "input": "Concept: down-regulation of tensidol B biosynthetic process (negative regulation of cellular amide metabolic process)", + "output": "negative regulation of small molecule metabolic process described as any process that stops, prevents or reduces the frequency, rate or extent of tensidol B biosynthetic process." + }, + { + "input": "Concept: X11L binding (Protein Binding)", + "output": "Protein Binding described as interacting selectively and non-covalently with X11-like protein, a neuron-specific adaptor protein." + }, + { + "input": "Concept: gullet (abdominal organ)", + "output": "Mouth, esophagus and stomach structures described as organ with organ cavity which is continuous proximally with the pharynx and distally with the stomach. Examples: There is only one esophagus." + }, + { + "input": "Concept: POG Neuroblastoma Stage D (Pediatric Oncology Group Neuroblastoma Staging System)", + "output": "Classification described as tumor has spread beyond the intracavitary lymph nodes." + }, + { + "input": "Concept: Thioesterase, Palmitoyl (Hydrolase)", + "output": "Thiolester Hydrolases described as enzyme catalyzing reversibly the hydrolysis of palmitoyl-CoA or other long-chain acyl coenzyme A compounds to yield CoA and palmitate or other acyl esters. The enzyme is involved in the esterification of fatty acids to form triglycerides. EC 3.1.2.2." + }, + { + "input": "Concept: CC-BPRS 1988 Version TEST (Intellectual Product)", + "output": "something described as brief Psychiatric Rating Scale 1988 Version test name." + }, + { + "input": "Concept: Seasonal Affective Disorders (Mood disorders NEC)", + "output": "Mood disorders NEC described as a syndrome characterized by depressions that recur annually at the same time each year, usually during the winter months. Other symptoms include anxiety, irritability, decreased energy, increased appetite (carbohydrate cravings), increased duration of sleep, and weight gain. SAD (seasonal affective disorder) can be treated by daily exposure to bright artificial lights (PHOTOTHERAPY), during the season of recurrence." + }, + { + "input": "Concept: Healings, Wound (Morphologically altered structure)", + "output": "FIBROSES AND TISSUE REPAIR described as restoration of integrity to traumatized tissue." + }, + { + "input": "Concept: CALCULI (Mechanical abnormality)", + "output": "Body Substance described as accumulated material from the secretions of an organ. It is solid and representative examples include gallbladder stones, kidney stones, and salivary gland stones." + }, + { + "input": "Concept: ADD-Type Zinc-Finger (Amino Acid Sequence)", + "output": "something described as a zinc finger protein domain that is comprised of a C2C2 sequence in close proximity to an incomplete PHD domain containing a C4C4 sequence." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Hematology, Fibrinolysis, Plasmin Inhibitor (Medical Device)", + "output": "Medical Device described as hematology reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (typically plasma) to determine plasmin inhibitors, a group of serine protease inhibitors (serpins) that include alpha2-antiplasmin and alpha2-macroglobulin. Plasmin inhibitors limit the action of plasmin to the area of fibrin deposition, avoiding the circulation of fibrinogen in blood." + }, + { + "input": "Concept: Structured Product Labeling Tissue Form Product Group Terminology (Intellectual Product)", + "output": "SPL Blood and Tissue Form Terminology described as terminology used to qualify the information pertaining to tissue form product groups in the framework of the Structured Product Labeling documents." + }, + { + "input": "Concept: 'curvilinear profiles' ultrastructurally (LABORATORY ABNORMALITIES)", + "output": "Finding described as an intracellular accumulation of autofluorescent lipopigment storage material in a curved pattern." + }, + { + "input": "Concept: sclerosing agents talc (Inorganic Chemical)", + "output": "Inorganic Chemical described as finely powdered native hydrous magnesium silicate. It is used as a dusting powder, either alone or with starch or boric acid, for medicinal and toilet preparations. It is also an excipient and filler for pills, tablets, and for dusting tablet molds." + }, + { + "input": "Concept: Focal Date Range (Temporal Concept)", + "output": "Date Range described as the time period in which the entity is held to be true." + }, + { + "input": "Concept: ([D]Debility, unspecified) or (endocrine symptoms)", + "output": "Substance Withdrawal Severity described as the property of lacking physical strength." + }, + { + "input": "Concept: Hemizygous (Qualitative Concept)", + "output": "Qualitative Concept described as having only one copy of a particular gene or genetic region." + }, + { + "input": "Concept: negative regulation of nematode larval development (Biologic Function)", + "output": "negative regulation of post-embryonic development described as any process that decreases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." + }, + { + "input": "Concept: TPO (Gene or Genome)", + "output": "something described as this gene plays a role in promoting megakaryocytopoiesis, the cellular development process that leads to platelet production." + }, + { + "input": "Concept: Structure of central nervous system (Nervous system structure)", + "output": "Nervous system structure described as main information processing organs of the nervous system, consisting of the brain, spinal cord, and meninges." + }, + { + "input": "Concept: Clostridium cochlearium (Douglas et al. 1919) Bergey et al. 1923 (Clostridium species a-f)", + "output": "something described as a species of anaerobic, Gram positive, rod shaped bacteria assigned to the phylum Firmicutes. This species is sporulating, produces glutamate mutase, hydrolyzes gelatin, is indole positive, lecithinase and lipase negative and does not ferment inositol, glucose or maltose. C. cochlearium is pathogenic." + }, + { + "input": "Concept: Non-target Enhancing Lesion Identification (Lesion Identification)", + "output": "Finding described as the identification of a contrast-enhancing tumor, lesion, or site of disease that is present at baseline and not considered a target, but may be part of the objective assessment of the response to the therapeutic intervention." + }, + { + "input": "Concept: Grade 2 Vertigo, CTCAE (Vertigo, CTCAE)", + "output": "Vertigo, CTCAE described as moderate symptoms; limiting instrumental ADL" + }, + { + "input": "Concept: M5a leukemia, adult acute (Acute monoblastic leukemia)", + "output": "Adult Acute Monoblastic and Monocytic Leukemia described as an acute monoblastic leukemia occurring in adults." + }, + { + "input": "Concept: catabolism of host structural constituent by organism (Organism Function)", + "output": "something described as the chemical reactions and pathways performed by an organism resulting in the breakdown of cellular components of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." + }, + { + "input": "Concept: ADNI AVLT - List A Recall 3 Word 13 (ADNI-AVLT Questionnaire Question)", + "output": "something described as alzheimer's Disease Neuroimaging Initiative Auditory Verbal Learning Test Version A (ADNI-AVLT Version A) List A, Recall 3, Word 13." + }, + { + "input": "Concept: Catheters, Biliary, Manometric (Medical Device)", + "output": "something described as biliary catheters used for measuring pressure in the biliary and/or pancreatic ducts, especially in the smooth muscle fibers investing the associated bile and pancreatic passages as they traverse the wall of the duodenum (sphincter of Oddi). These devices usually consist of a triple-lumen 5 Fr catheter including two or three leads, either with micropressure transducers located at their distal tip or with open-end, fluid-filled pressure catheters attached to an external strain-gauge transducer. Most of them include openings for aspiration purposes. Manometric biliary catheters are frequently used for evaluation of postcholecystectomy pain and for assessing sphincter of Oddi dysfunction." + }, + { + "input": "Concept: Carcinogenesis, Radiation (Carcinogenesis)", + "output": "something described as cancer formation caused by exposure to radiation." + }, + { + "input": "Concept: DDS01-Doctor Doesn't Understand (Intellectual Product)", + "output": "T1-DDS Questionnaire Question described as diabetes Distress Scale for Adults with Type 1 Diabetes - Over the past month, please indicate the degree to which each of the following may have been a problem for you: Feeling that my diabetes doctor doesn't really understand what it's like to have diabetes." + }, + { + "input": "Concept: Grade 3 Neonatal Hypotension, Adverse Event (Finding)", + "output": "Finding described as persistent hypotension affecting perfusion; requiring major care change (e.g. vaso-active drugs or hydrocortisone)." + }, + { + "input": "Concept: CHOLECYSTECTOMY LAPAROSCOPIC (Therapeutic or Preventive Procedure)", + "output": "Gallbladder endoscopy described as excision of the gallbladder through an abdominal incision using a laparoscope." + }, + { + "input": "Concept: pavor nocturnus (Parasomnia)", + "output": "Parasomnia described as a disorder characterized by incomplete arousals from sleep associated with behavior suggesting extreme fright. This condition primarily affects children and young adults and the individual generally has no recall of the event. Episodes tend to occur during stage III or IV. SOMNAMBULISM is frequently associated with this condition." + }, + { + "input": "Concept: oral bacteria (bacteria characteristic)", + "output": "bacteria characteristic described as see RTs for specific organisms." + }, + { + "input": "Concept: PODCI1-Full of Pep and Energy (PODCI Pediatric Parent-Reported Version Questionnaire Question)", + "output": "Intellectual Product described as pediatric Outcomes Data Collection Instrument, Pediatric Parent-Reported - During the last week, how much of the time: Were your child full of pep and energy?" + }, + { + "input": "Concept: Guadeloupe (Country)", + "output": "Lesser Antilles island described as a group of islands in the Caribbean Seas, southeast of Montserrat." + }, + { + "input": "Concept: FSGS1 (Gene or Genome)", + "output": "something described as this gene plays a role in the binding of actin to other cellular structures." + }, + { + "input": "Concept: FACT-BRM Version 4 - I Am Able to Enjoy Life (FACT-BRM Version 4 Questionnaire Question)", + "output": "something described as functional Assessment of Cancer Therapy-Biologic Response Modifiers Version 4 - Functional Well-Being: I am able to enjoy life." + }, + { + "input": "Concept: Tractus subthalamicotegmentalis (Body Part, Organ, or Organ Component)", + "output": "something described as a substructure of the interbrain and the midbrain that is not readily distinguished in myelin-stained histological cross-sections ( Roberts-1970 )." + }, + { + "input": "Concept: acyl-CoA delta(5)-desaturase activity (Molecular Function)", + "output": "something described as catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = delta5-acyl-CoA + acceptor + 2 H2O." + }, + { + "input": "Concept: DNA synthesis involved in double-strand break repair via homologous recombination (DNA synthesis involved in DNA repair)", + "output": "something described as the synthesis of DNA that contributes to the process of double-strand break repair via homologous recombination." + }, + { + "input": "Concept: Endoresection (Ophthalmologic Surgical Procedures)", + "output": "Therapeutic or Preventive Procedure described as a surgical technique used for the resection of posteriorly located uveal melanomas without ciliary body involvement via pars plana vitrectomy." + }, + { + "input": "Concept: Excessive magnesium intake (Finding)", + "output": "Finding described as higher intake of magnesium compared to established reference standards or recommendations based on physiological needs (Source: International Dietetics and Nutrition Terminology (IDNT) Reference Manual, edition 4; ISBN #978-0-88091-467-3)" + }, + { + "input": "Concept: MB1 (CD79A gene)", + "output": "Gene or Genome described as human CD79A wild-type allele is located in the vicinity of 19q13.2 and is approximately 4 kb in length. This allele, which encodes B-cell antigen receptor complex-associated protein alpha chain protein, plays a role in the positive stimulation of B-cell proliferation and signaling. Mutation of the gene is associated with agammaglobulinemia type 3 and may be associated with diffuse large B-cell lymphoma." + }, + { + "input": "Concept: functional incontinence (Elimination pattern)", + "output": "Other symptoms and signs involving the genitourinary system described as involuntary, unpredictable passage of urine" + }, + { + "input": "Concept: Nose Clips (Clip)", + "output": "Medical Device described as clips designed to be applied to the external portions of the nose; depending on the location of application, these clips can provide a method for occluding the external orifices of the nose (i.e., nares), blocking the nasal passage and thereby preventing air movement through the nose. Alternatively, if these clips are applied to the nasal septum (i.e., the part that separates the two nostrils), they can be used to apply pressure on the trigeminal nerve in the septum, causing a dilation of the nasal passage and thereby serving as a breathing aid. These clips are typically small instruments with two blades joined at the midportion or made from a single alpha-shaped part; they are made out of metal or plastic with rubber or foam tips." + }, + { + "input": "Concept: HAQ0230 (Intellectual Product)", + "output": "HAQ-DI Without VAS Questionnaire Question described as health Assessment Questionnaire Disability Index Without Pain Visual Analog Scale (HAQ-DI Without VAS) Grip: Are you able to turn faucets on and off?" + }, + { + "input": "Concept: IVD Test Reagent/Kits, Immunohematology, Antibody Detection/Identification, Antiglobulin, Polyspecific (Medical Device)", + "output": "something described as immunohematology reagents including antiglobulin serum with both antihuman immunoglobulin G and anticomplement activity (i.e., polyspecific antihuman serum). Polyspecific antiglobulin serum is obtained either by the injection of an animal with human globulin or through hybridoma technology. These reagents, unlike monospecific antiglobulin serum antibodies, may detect antibodies that bind complements to the red blood cells being tested." + }, + { + "input": "Concept: Surefire Antireflux Microcatheter (Arterial catheter)", + "output": "something described as a proprietary catheter with an expandable tip designed to increase infusion pressure while maintaining antegrade blood flow in order to deliver a higher concentration of agents to a target." + }, + { + "input": "Concept: Foreign Language Translation (Testing)", + "output": "something described as rendering from one language to another. Use with foreign language test translations." + }, + { + "input": "Concept: PANSS1-Tension (Intellectual Product)", + "output": "something described as positive and Negative Syndrome Scale - Tension." + }, + { + "input": "Concept: Late Term Birth (Finding)", + "output": "something described as birth at 41 weeks and 0 days through 41 weeks and 6 days gestation." + }, + { + "input": "Concept: Born very premature (Infant, Premature)", + "output": "Infant, Premature described as an infant born after 28 completed weeks of gestation and before 32 completed weeks of gestation." + }, + { + "input": "Concept: NIR Fluorescence Endoscopy (Endoscopy)", + "output": "something described as the use of near-infrared light (700-1000 nm) for biomedical imaging with an endoscope." + }, + { + "input": "Concept: Temperature 40 (+/-) 2 Degrees C and Relative Humidity Not More Than 25% (WHO Temperature/Humidity Storage Condition)", + "output": "Qualitative Concept described as storage at 40 degrees C (+/-) 2 degrees C and Relative Humidity not more than 25%." + }, + { + "input": "Concept: CSS10-Non-suicidal Self-injur Behav-Life (Intellectual Product)", + "output": "something described as columbia-Suicide Severity Rating Scale Pediatric/Cognitively Impaired Lifetime/Recent - Has subject engaged in non-suicidal self-injurious behavior? (Lifetime)." + }, + { + "input": "Concept: Discs, Imaginal (Animal Structures)", + "output": "invertebrate embryology described as hollow sacs of cells in LARVA that form adult structures in insects during BIOLOGICAL METAMORPHOSIS." + }, + { + "input": "Concept: SODIUM THIOSULFATE (Drug allergens)", + "output": "Sodium Compounds described as a water soluble salt and reducing agent that reacts with oxidizing agents. Although its exact mechanism of action is unknown, thiosulfate likely provides an exogenous source of sulfur, thereby hastening the detoxification of cyanide through the enzyme rhodanese (thiosulfate cyanide sulfurtransferase) which converts cyanide to the relatively nontoxic, excretable thiocyanate ion. In addition, this agent neutralizes the reactive alkylating species of nitrogen mustard, thereby decreasing skin toxicity related to nitrogen mustard extravasation. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1230\" active clinical trials using this agent." + }, + { + "input": "Concept: Mitomycin A (Organic Chemical)", + "output": "Organic Chemical described as a methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus. Bioreduced mitomycin A generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Mitomycin A is more toxic than mitomycin C due to increased and nonselective DNA cross-linking in both aerobic and hypoxic cells." + }, + { + "input": "Concept: Screening Result (Conceptual Entity)", + "output": "Conceptual Entity described as a Screening Result captures the results of the tens of thousands of compounds screened for their ability to inhibit the growth of selected yeast strains altered in DNA damage repair or cell cycle control." + }, + { + "input": "Concept: negative regulation of IL-6 production (Organism Function)", + "output": "negative regulation of cytokine production described as any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production." + }, + { + "input": "Concept: cytokine precursor processing (Cell Function)", + "output": "Cell Function described as the cleavage of a peptide bond in a precursor form of a cytokine, resulting in the mature (active) form of the cytokine." + }, + { + "input": "Concept: radiodermatitis (Radiation injury)", + "output": "Korean Standard Classification of Disease Version 5 described as a skin condition that is a common side effect of radiation therapy. The affected skin becomes painful, red, itchy, and blistered." + }, + { + "input": "Concept: negative regulation of myosin light chain kinase activity (negative regulation of protein serine/threonine kinase activity)", + "output": "something described as any process that stops, prevents, or reduces the frequency, rate or extent of myosin light chain kinase activity." + }, + { + "input": "Concept: True False Response Terminology (Intellectual Product)", + "output": "Terminology Subset described as terminology codelist used for any True False responses." + }, + { + "input": "Concept: Eserinum / eserine (Organic Chemical)", + "output": "Homeopathic remedies letter E described as eserine." + }, + { + "input": "Concept: RAND-36 - Health Limit Walking One Block (RAND-36 Questionnaire Question)", + "output": "RAND-36 Questionnaire Question described as RAND 36-Item Health Survey 1.0 - Does your health now limit you in these activities: Walking one block." + }, + { + "input": "Concept: Narrow interpedicular space (Vertebral column)", + "output": "Vertebral arch anomaly described as a reduction of the distance between vertebral pedicles, which are the two short, thick processes, which project backward, one on either side, from the upper part of the vertebral body, at the junction of its posterior and lateral surfaces." + }, + { + "input": "Concept: Childhood Solid Neoplasm (Pediatric Neoplasm)", + "output": "Neoplastic Process described as a solid neoplasm (e.g., carcinoma, sarcoma) occurring in children." + }, + { + "input": "Concept: HAQ0243 (HAQ-DI Without VAS Questionnaire Question)", + "output": "HAQ-DI Without VAS Questionnaire Question described as health Assessment Questionnaire Disability Index Without Pain Visual Analog Scale (HAQ-DI Without VAS) Usually need help from another person: Reach." + }, + { + "input": "Concept: Bermuda Grass Pollen IgA Measurement (Immunoglobulin measurement)", + "output": "Laboratory Procedure described as a measurement of the Cynodon dactylon pollen antigen IgA antibody in a biological specimen." + }, + { + "input": "Concept: Suppliers; Hearing Aid Equipment (HealthcareProviderTaxonomyHIPAA - CodeSystem)", + "output": "something described as the manufacture and/or sale of electronic hearing aids, their component parts, and related products and services on a national basis." + }, + { + "input": "Concept: ORGANOTHIOPHOSPHORUS CPDS (Sulfur Compounds)", + "output": "something described as compounds containing carbon-phosphorus bonds in which the phosphorus component is also bonded to one or more sulfur atoms. Many of these compounds function as CHOLINERGIC AGENTS and as INSECTICIDES." + }, + { + "input": "Concept: POG 9245 Regimen (Regimen Used to Treat Childhood Hodgkins Lymphoma)", + "output": "Regimen Used to Treat Childhood Hodgkins Lymphoma described as a regimen consisting of doxorubicin, bleomycin, vincristine, etoposide, prednisone and cyclophosphamide, given in combination with radiation therapy and used for the treatment of high-risk, childhood Hodgkin's lymphoma." + }, + { + "input": "Concept: Document Version Uniform Resource Locator (Intellectual Product)", + "output": "something described as a complete reference to a website (including http://) from which the document contents can be retrieved." + }, + { + "input": "Concept: Product containing fluorometholone (Corticosteroid [EPC])", + "output": "Ophthalmologic drugs described as a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. Fluorometholone exerts its effects by interacting with cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited. As a result, there is an overall reduction in chronic inflammation and autoimmune reactions." + }, + { + "input": "Concept: Idiopathic Calciphylaxis (Disease or Syndrome)", + "output": "Extraskeletal calcification described as a rare syndrome characterized by vascular calcification and skin necrosis. It seen in patients with end stage renal disease." + }, + { + "input": "Concept: MOv-gamma (Transduction Gene)", + "output": "Transduction Gene described as a recombinant engineered chimeric gene derived from the murine gene encoding the variable region of monoclonal antibody MOv18 against folate-binding protein, which is often overexpressed in human ovarian cancer cells, and the gene encoding the Fc receptor for the gamma subunit of human IgG and IgE. Peripheral blood lymphocytes expressing the MOv-gamma gene may be used in the immunotherapeutic treatment of ovarian cancer. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2638\" active clinical trials using this agent." + }, + { + "input": "Concept: ventral part of the pontine reticular nucleus (Body Part, Organ, or Organ Component)", + "output": "Body Part, Organ, or Organ Component described as a small portion of the caudal pontine reticular nucleus defined by some authors on the basis of Nissl stain. It is located ventromedially adjacent to the nucleus raphe magnus ( Paxinos-2009, Hof-2000 )." + }, + { + "input": "Concept: Vascularization of cornea (Corneal Diseases)", + "output": "Corneal Neovascularization described as ingrowth of new blood vessels into the cornea." + }, + { + "input": "Concept: Grade 2 Skin Ulceration, CTCAE (Skin Ulceration, CTCAE)", + "output": "Finding described as combined area of ulcers 1-2 cm; partial thickness skin loss involving skin or subcutaneous fat" + }, + { + "input": "Concept: Optical Disk Device (Manufactured Object)", + "output": "something described as a data storage disk where the data is stored in a format to be read optically by a laser and receiver." + }, + { + "input": "Concept: CMD (Non-Neoplastic Heart Disorder)", + "output": "Disease or Syndrome described as a condition in which there is angina pectoris due to occlusion of the smaller coronary arteries." + }, + { + "input": "Concept: regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling (mesenchymal-epithelial cell signaling)", + "output": "Cell Function described as any process that modulates the rate, frequency, or extent of branching involved in salivary gland morphogenesis as a result of signals being generated by the mesenchyme and received and interpreted by the salivary gland epithelium." + }, + { + "input": "Concept: Brachydactyly and preaxial hallux varus syndrome (Congenital hallux varus)", + "output": "Hereditary disorder of musculoskeletal system described as the association of hallux varus with short thumbs and first toes (involving the metacarpals, metatarsals, and distal phalanges; the proximal and middle phalanges are of normal length) and abduction of the affected digits. The syndrome has been described in eight affected individuals from four successive generations of one family. Intellectual deficit was observed in all reported individuals. Transmission appears to be autosomal dominant." + }, + { + "input": "Concept: positive regulation of IL-16 biosynthesis (positive regulation of interleukin-16 production)", + "output": "regulation of interleukin-16 biosynthetic process described as any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16." + }, + { + "input": "Concept: Sebaceous nevus, central nervous system malformations, aplasia cutis congenita, limbal dermoid, pigmented nevus syndrome (Multiple system malformation syndrome)", + "output": "Nevus sebaceous described as a rare skin disease characterized by the association of sebaceous nevus and aplasia cutis congenita (usually on the scalp and face) in conjunction with limbal dermoid of the eye, a giant congenital melanocytic nevus and variable central nervous system abnormalities including seizures, hydrocephalus, neurocutaneous melanosis, arachnoid cysts, and diffuse unilateral hemisphere enlargement." + }, + { + "input": "Concept: Polygonal Shape (Shapes)", + "output": "something described as a closed plane figure bounded by straight sides." + }, + { + "input": "Concept: HSGAG mimetic M402 (Organic Chemical)", + "output": "Antineoplastic Agents described as a low molecular weight heparin derivative and heparan sulfate proteoglycan (HSPG) mimetic with no or minimal anticoagulant activity and potential antineoplastic activities. Upon administration, M402 mimics HSPGs by binding to and inhibiting various heparin-binding growth factors, chemokines, and cytokines such as VEGF, HGF, FGF2, SDF-1a, heparanase and P-selectin all of which are essential for tumor angiogenesis and metastasis to occur. This inhibits heparin binding growth factor-mediated signaling and disrupts tumor-stromal interactions eventually leading to an inhibition of angiogenesis and tumor cell progression. In addition, M402 may enhance the cytotoxic effect of other chemotherapeutic agents. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C102749\" active clinical trials using this agent." + }, + { + "input": "Concept: Protein Arginine N-Methyltransferase 1 (Biologically Active Substance)", + "output": "Biologically Active Substance described as protein arginine N-methyltransferase 1 (361 aa, ~42 kDa) is encoded by the human PRMT1 gene. This protein plays a role in the methylation of the guanidino nitrogens of arginyl residues in substrate proteins." + }, + { + "input": "Concept: N-Phenylsalicylamides (Organic Chemical)", + "output": "something described as 2-Hydroxy-N-phenylbenzamides. N-phenyl substituted salicylamides. Derivatives have been used as fungicides, anti-mildew agents and topical antifungal agents. In concentrated form may cause irritation of skin and mucous membranes." + }, + { + "input": "Concept: PANSS105 (Intellectual Product)", + "output": "PANSS Clinical Classification Question described as positive and Negative Syndrome Scale - Grandiosity." + }, + { + "input": "Concept: Standing individual each 15 minutes (Therapeutic or Preventive Procedure)", + "output": "Therapeutic or Preventive Procedure described as facilitating education or reeducation of a client to correct his or her standing techniques, including proper weight distribution and leg, back, neck and arm positioning. Service is billed in 15-minute increments." + }, + { + "input": "Concept: Grade 3 Forced expiratory volume decreased (Finding)", + "output": "something described as 50-59%" + }, + { + "input": "Concept: Rifomycin (Anti-Bacterial Agents)", + "output": "Antibiotic described as a group of ANTI-BACTERIAL AGENTS characterized by a chromophoric naphthohydroquinone group spanned by an aliphatic bridge not previously found in other known ANTI-BACTERIAL AGENTS. They have been isolated from fermentation broths of Streptomyces mediterranei." + }, + { + "input": "Concept: DNA replication termination involved in cell cycle DNA replication (DNA replication termination)", + "output": "cell cycle process described as any DNA replication termination that is involved in cell cycle DNA replication." + }, + { + "input": "Concept: Fluorouracil Topical (pyrimidine analog)", + "output": "Thymidylate synthase inhibitor described as a topical formulation containing the antimetabolite 5-fluorouracil (5-FU), with antineoplastic activity. Upon topical administration, 5-FU is converted into the active metabolite 5-fluoroxyuridine monophosphate (F-UMP), which competes with uracil during RNA synthesis and inhibits RNA processing. Conversion of 5-FU into another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP), inhibits thymidylate synthase; this results in the depletion of thymidine triphosphate (TTP), one of the four nucleotide triphosphates used in DNA synthesis, and thus inhibits DNA synthesis. Altogether, this prevents the proliferation of tumor cells locally. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C125194\" active clinical trials using this agent." + }, + { + "input": "Concept: distillates petroleum (Petroleum)", + "output": "something described as hydrocarbon solvents with flash points above 38 degrees C" + }, + { + "input": "Concept: Quinestrolum (Estrogens and Progestogens)", + "output": "Estrogens and Progestogens described as the 3-cyclopentyl ether of ETHINYL ESTRADIOL. After gastrointestinal absorption, it is stored in ADIPOSE TISSUE, slowly released, and metabolized principally to the parent compound. It has been used in ESTROGEN REPLACEMENT THERAPY." + }, + { + "input": "Concept: amyloplast envelope (plastid envelope)", + "output": "plastid envelope described as the double lipid bilayer enclosing the amyloplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." + }, + { + "input": "Concept: cell migration involved in metanephric kidney development (Cell Function)", + "output": "something described as the orderly movement of a cell from one site to another that will contribute to the progression of the metanephric kidney over time, from its formation to the mature organ." + }, + { + "input": "Concept: PFR (Cell Component)", + "output": "something described as a large lattice-like axial structure found in some flagellated protists which extends alongside the axoneme. Protein components of the paraflagellar rod are likely implicated, among other, in adenine nucleotide signalling and metabolism, and in calcium signalling." + }, + { + "input": "Concept: Cells, Feeder (Cell)", + "output": "Cell described as cells used in COCULTURE TECHNIQUES which support the growth of the other cells in the culture. Feeder cells provide auxillary substances including attachment substrates, nutrients, or other factors that are needed for growth in culture." + }, + { + "input": "Concept: 2p21 (Chromosome band)", + "output": "Cell Component described as a chromosome band present on 2p" + }, + { + "input": "Concept: HGF RECEPT (Proto-Oncogene Proteins)", + "output": "Amino Acid, Peptide, or Protein described as cell surface protein-tyrosine kinase receptors for HEPATOCYTE GROWTH FACTOR. They consist of an extracellular alpha chain which is disulfide-linked to the transmembrane beta chain. The cytoplasmic portion contains the catalytic domain and sites critical for the regulation of kinase activity. Mutations in the c-met proto-oncogene are associated with papillary renal carcinoma and other neoplasia." + }, + { + "input": "Concept: Delayed upper limb epiphyseal ossification (Delayed epiphyseal ossification)", + "output": "Delayed epiphyseal ossification described as a delay in the process of formation and maturation of the epiphysis of one or more long bones of the upper limbs." + }, + { + "input": "Concept: ADP-ribosyltransferase (polymerizing) activity (Molecular Function)", + "output": "pentosyltransferase activity described as catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." + }, + { + "input": "Concept: AZO DYE, CALCIUM (Indicator, Reagent, or Diagnostic Aid)", + "output": "something described as a calcium test system is a device intended to measure the total calcium level in serum. Calcium measurements are used in the diagnosis and treatment of parathyroid disease, a variety of bone diseases, chronic renal disease and tetany (intermittent muscular contractions or spasms)." + }, + { + "input": "Concept: School health services (Preventive Health Services)", + "output": "Preventive Health Services described as preventive health services provided for students. It excludes college or university students." + }, + { + "input": "Concept: formate dehydrogenase (coenzyme F420) activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the reaction: formate + coenzyme F420 = CO2 + reduced coenzyme F420." + }, + { + "input": "Concept: Glycerone-transferase (Enzyme)", + "output": "Amino Acid, Peptide, or Protein described as an enzyme of the transferase class that catalyzes the reaction sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate to yield D-erythrose 4-phosphate and D-fructose phosphate in the PENTOSE PHOSPHATE PATHWAY. (Dorland, 27th ed) EC 2.2.1.2." + }, + { + "input": "Concept: COAG LASER (Light Coagulation)", + "output": "Laser Surgery described as the use of green light-producing LASERS to stop bleeding. The green light is selectively absorbed by HEMOGLOBIN, thus triggering BLOOD COAGULATION." + }, + { + "input": "Concept: U7 snRNP location (small nuclear ribonucleoprotein complex location)", + "output": "Cell Component described as a ribonucleoprotein complex that contains the U7 snRNA and is required for the 3'-end processing of replication-dependent histone pre-mRNAs." + }, + { + "input": "Concept: Amino Acid Substitutions (Genetic Function)", + "output": "Genetic Function described as the naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties." + }, + { + "input": "Concept: protein complex subunit organisation (cellular component organization)", + "output": "something described as any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex." + }, + { + "input": "Concept: HRNBP1 (Gene or Genome)", + "output": "something described as this gene plays a role in mRNA processing." + }, + { + "input": "Concept: alpha-tocopherol 13-hydroxylase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the reaction: alpha-tocopherol + O2 + NADPH + H+ = 13'-hydroxy-alpha-tocopherol + NADP+ + H2O ." + }, + { + "input": "Concept: Anaerobic Gram-positive coccus (Bacterium)", + "output": "Bacterium described as any spherical-shaped bacteria that does not require oxygen to grow or respirate and has a peptidoglycan-rich cell wall that stains dark purple with the Gram staining technique." + }, + { + "input": "Concept: Physical Growth (Biological Processes)", + "output": "Student health status described as increase in physical dimensions or maturity of organ systems" + }, + { + "input": "Concept: umol*h2/mL (Quantitative Concept)", + "output": "Measurement Unit Description described as hours squared times millimoles per liter (area under the moment curve)." + }, + { + "input": "Concept: Mitochondrial inner membrane peptidase complex (Mitochondrial protein complex)", + "output": "Mitochondrial protein complex described as protease complex of the mitochondrial inner membrane, consisting of at least two subunits, involved in processing of both nuclear- and mitochondrially-encoded proteins targeted to the intermembrane space." + }, + { + "input": "Concept: craniofacial dysostosis (congenital morphologic anomaly)", + "output": "Disease or Syndrome described as a syndrome inherited in an autosomal dominant pattern. It is characterized by early fusion of the bones of the skull and face. Patients have a distinctive facial appearance which includes low-set ears, brachycephaly, hypertelorism, exophthalmos, and mandibular prognathism." + }, + { + "input": "Concept: Grade 4 Oral Hemorrhage, CTCAE (Oral Hemorrhage, CTCAE)", + "output": "something described as life-threatening consequences; urgent intervention indicated" + }, + { + "input": "Concept: FAC06237 (Intellectual Product)", + "output": "FACT-BRM Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Biologic Response Modifiers Version 4 (FACT-BRM Version 4) Additional Concerns-Mental: I get depressed easily." + }, + { + "input": "Concept: CTC (Cell Count)", + "output": "Cell Count described as the determination of the amount of circulating tumor cells present in a sample." + }, + { + "input": "Concept: Oropharyngeal (p16-Negative) Cancer cNX TNM Finding v8 (Finding)", + "output": "Finding described as oropharyngeal (p16-negative) cancer in which the regional lymph nodes cannot be assessed." + }, + { + "input": "Concept: DRRI1-O: I Can Talk About My Deployment (DRRI-2 Questionnaire Question)", + "output": "DRRI-2 Questionnaire Question described as deployment Risk and Resilience Inventory-2 (DRRI-2) Since returning: there are family and/or friends with whom I can talk about my deployment experiences." + }, + { + "input": "Concept: Propenoic Acid Amide (A [Preparations])", + "output": "Organic Chemical described as colorless, odorless, highly water soluble vinyl monomer formed from the hydration of acrylonitrile; primarily used in research laboratories for electrophoresis, chromatography, and electron microscopy and in the sewage and wastewater treatment industries." + }, + { + "input": "Concept: Sleeves, Topical Oxygen Therapy (Medical Device)", + "output": "Sleeve described as devices designed to serve as a reservoir for low-pressure (i.e., 1.05 ATM) oxygen-enriched air during topical oxygen therapy procedures. During a procedure, these sleeves are placed on the patient over/surrounding a wound site, and the sleeve is insufflated with oxygen-enriched air to the intended pressure. These sleeves are typically constructed of a flexible plastic material and are available in multiple shapes appropriate for various patient anatomic locations (e.g., lower limb boot, sacral patch). These devices typically incorporate an air-inlet valve, a pressure-relief valve, and a method of sealing the open end of the sleeve to the patient's skin in order to prevent air loss." + }, + { + "input": "Concept: Teninitis (Musculoskeletal Diseases)", + "output": "something described as acute tendon injury accompanied by inflammation." + }, + { + "input": "Concept: Confident sexually (Clinical or Research Assessment Question)", + "output": "something described as a question about how often an individual feels confident sexually." + }, + { + "input": "Concept: meningiomatosis (Meningiomas, Multiple)", + "output": "Meningeal neoplasm, uncertain whether benign or malignant described as the presence of multiple meningiomas in the leptomeninges." + }, + { + "input": "Concept: caffeate 3-O-methyltransferase activity (Molecular Function)", + "output": "O-methyltransferase activity described as catalysis of the reaction: S-adenosyl-L-methionine + 3,4-dihydroxy-trans-cinnamate = S-adenosyl-L-homocysteine + 3-methoxy-4-hydroxy-trans-cinnamate." + }, + { + "input": "Concept: 2-deoxystreptamine catabolic process (2-deoxystreptamine metabolic process)", + "output": "antibiotic catabolic process described as the chemical reactions and pathways resulting in the breakdown of 2-deoxystreptamine." + }, + { + "input": "Concept: GDS0103 (GDS Questionnaire Question)", + "output": "Intellectual Product described as geriatric Depression Scale - Do you feel that your life is empty?" + }, + { + "input": "Concept: B-1 B-lymphocyte differentiation (Cell Function)", + "output": "mature B cell differentiation described as the process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." + }, + { + "input": "Concept: neuroimaging (nervous system disorder diagnosis)", + "output": "Assessment & Diagnosis described as non-invasive methods of visualizing the CENTRAL NERVOUS SYSTEM, especially the brain, by various imaging modalities." + }, + { + "input": "Concept: renal stenting (Medical Device)", + "output": "something described as a metal scaffold placed via a delivery catheter into the renal artery to maintain the lumen" + }, + { + "input": "Concept: Placental dysplasia (Placental abnormalities)", + "output": "Disease or Syndrome described as aberrant mesenchymal cell growth within the placenta. It may be associated with Beckwith-Wiedemann Syndrome." + }, + { + "input": "Concept: IDH1 inhibitor (Organic Chemical)", + "output": "Organic Chemical described as any agent that inhibits isocitrate dehydrogenase (IDH) type 1 (IDH1, IDH1 [NADP+] soluble) found in the cytoplasm." + }, + { + "input": "Concept: Abnormal helix (Ear structure)", + "output": "Ear structure described as an abnormality of the helix. The helix is the outer rim of the ear that extends from the insertion of the ear on the scalp (root) to the termination of the cartilage at the earlobe." + }, + { + "input": "Concept: postnodular fissure (Structure of cerebellar fissure)", + "output": "something described as a medial extension of the posterolateral fissure of the cerebellum ( Crosby-1962 )." + }, + { + "input": "Concept: SIQ01-Critical Item 2 (Intellectual Product)", + "output": "SIQ Questionnaire Question described as suicidal Ideation Questionnaire (SIQ) Critical item 2." + }, + { + "input": "Concept: NCI CTEP SDC Tumors of the Sellar Region Sub-Category Terminology (Intellectual Product)", + "output": "NCI CTEP SDC CNS Neoplasm (Primary Tumor) Category Terminology described as tumors of the Sellar Region is an NCI Cancer Therapeutic Evaluation Program (CTEP) Simplified Disease Classification (SDC) category used to organize cancer-related disease coding that harmonizes with and supports reporting based on the global standard Medical Dictionary for Drug Regulatory Reporting (MedDRA) terminology." + }, + { + "input": "Concept: Allopathic & Osteopathic Physicians; Obstetrics & Gynecology, Female Pelvic Medicine and Reconstructive Surgery (Professional or Occupational Group)", + "output": "something described as a subspecialist in Female Pelvic Medicine and Reconstructive Surgery is a physician in Urology or Obstetrics and Gynecology who, by virtue of education and training, is prepared to provide consultation and comprehensive management of women with complex benign pelvic conditions, lower urinary tract disorders, and pelvic floor dysfunction. Comprehensive management includes those diagnostic and therapeutic procedures necessary for the total care of the patient with these conditions and complications resulting from them." + }, + { + "input": "Concept: MIRLET7D gene (MicroRNA Gene)", + "output": "Gene or Genome described as this gene is involved in the regulation of gene expression and plays a tumor suppressor role in lung and ovarian carcinomas, uterine leiomyoma and acute promyelocytic leukemia." + }, + { + "input": "Concept: RAND-36 - Health Limit Climbing Several Flights (RAND-36 Questionnaire Question)", + "output": "RAND-36 Questionnaire Question described as RAND 36-Item Health Survey 1.0 (RAND-36) Does your health now limit you in these activities: Climbing several flights of stairs." + }, + { + "input": "Concept: regulation of cytokine production (Organism Function)", + "output": "Gene Expression Regulation described as any process that modulates the frequency, rate, or extent of production of a cytokine." + }, + { + "input": "Concept: abasic endoribonuclease activity (endoribonuclease activity, producing 5'-phosphomonoesters)", + "output": "Genetic Function described as catalysis of the hydrolysis of ester linkages immediately 5' to an apurinic/apyrimidinic (AP; also called abasic) site within a ribonucleic acid molecule by creating internal breaks, generating a single-strand break with 5'-ribose phosphate and 3'-hydroxyl ends." + }, + { + "input": "Concept: DNA injury (Genetic Processes)", + "output": "PURINES, PYRIMIDINES AND NUCLEIC ACIDS described as injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS." + }, + { + "input": "Concept: limonene oxide hydrolase activity (Molecular Function)", + "output": "something described as catalysis of the reaction: limonene-1,2-epoxide + H2O = limonene-1,2-diol. Other substrates include alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide." + }, + { + "input": "Concept: antihistamine (Histamine Antagonists)", + "output": "Pharmacologic Substance described as a type of drug that blocks the action of histamines, which can cause fever, itching, sneezing, a runny nose, and watery eyes. Antihistamines are used to prevent fevers in patients receiving blood transfusions and to treat allergies, coughs, and colds." + }, + { + "input": "Concept: leaf morphogenesis (Organ or Tissue Function)", + "output": "plant organ morphogenesis described as the process in which the anatomical structures of the leaf are generated and organized." + }, + { + "input": "Concept: Percutaneous two or more substance injection each injection (Therapeutic or Preventive Procedure)", + "output": "Injection procedure described as injecting two or more substances into a client/patient through his or her skin. Service is billed per injection." + }, + { + "input": "Concept: 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((aminophenylacetyl)amino)-3-methyl-8-oxo-, (6R-(6alpha,7beta(R*)))- (Drug allergens)", + "output": "Drug allergens described as an antibiotic drug" + }, + { + "input": "Concept: Kingella kingii (Bacterium)", + "output": "Kingella described as any bacterial organism that can be assigned to the species Kingella kingae." + }, + { + "input": "Concept: downregulation of lateral mesodermal cell fate determination (regulation of lateral mesodermal cell fate determination)", + "output": "something described as any process that stops, prevents, or reduces the frequency, rate or extent of lateral mesoderm cell fate determination." + }, + { + "input": "Concept: FAC10089 (Intellectual Product)", + "output": "something described as functional Assessment of Chronic Illness Therapy-Dyspnea Scale 33 Item Bank - Functional Limitation: Considering your shortness of breath over the past 7 days, rate the amount of difficulty you had when doing the following activities: Lifting something weighing more than 20 lbs (about 9 kg, like a medium-sized suitcase)." + }, + { + "input": "Concept: posterior intralaminar nucleus of the thalamus (Body Part, Organ, or Organ Component)", + "output": "something described as a group of cells ventral and medial to the medial geniculate body in the mouse ( Paxinos-2001 )." + }, + { + "input": "Concept: Arabinosylcytosine (Arabinonucleosides)", + "output": "C [Preparations] described as a drug used to treat certain types of leukemia and prevent the spread of leukemia to the meninges (three thin layers of tissue that cover and protect the brain and spinal cord). It is also being studied in the treatment of other types of cancer. Cytarabine blocks tumor growth by stopping DNA synthesis. It is a type of antimetabolite." + }, + { + "input": "Concept: Confocal Laser Scanning Microscopy (Microscopy)", + "output": "Microscopy described as a light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible." + }, + { + "input": "Concept: {Unit}/{animal} (Unit of Dose Calculation)", + "output": "Quantitative Concept described as an arbitrary dosing unit expressed in unit(s) per animal." + }, + { + "input": "Concept: electronic spectra (quantum chemistry)", + "output": "quantum chemistry described as emission or absorption of specific wavelengths of electromagnetic radiation during changes in the electron configurations of atoms, ions, or molecules." + }, + { + "input": "Concept: blood platelets; decreased (Hematological Disease)", + "output": "Platelet analyses described as a condition in which there is a lower-than-normal number of platelets in the blood. It may result in easy bruising and excessive bleeding from wounds or bleeding in mucous membranes and other tissues." + }, + { + "input": "Concept: DLL3 protein, human (Biologically Active Substance)", + "output": "Amino Acid, Peptide, or Protein described as delta-like protein 3 (618 aa, ~65 kDa) is encoded by the human DLL3 gene. This protein is involved in binding to notch proteins, mesoderm development and neurogenesis." + }, + { + "input": "Concept: DRRI1A08 (Intellectual Product)", + "output": "something described as deployment Risk and Resilience Inventory-2 (DRRI-2) Before deployment: I experienced a natural disaster (for example, a hurricane), a fire, or an accident in which I or someone close to me was hurt or had serious property damage." + }, + { + "input": "Concept: Neuronal Munc18-1-Interacting Protein 3 (Carrier Proteins)", + "output": "Amino Acid, Peptide, or Protein described as amyloid beta A4 precursor protein-binding family A member 3 (575 aa, ~61 kDa) is encoded by the human APBA3 gene. This protein is involved in the regulation of amyloid beta A4 precursor protein proteolysis." + }, + { + "input": "Concept: pyrimidine ribonucleotide formation (ribonucleotide biosynthetic process)", + "output": "pyrimidine ribonucleotide metabolic process described as the chemical reactions and pathways resulting in the formation of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." + }, + { + "input": "Concept: BMS-387032 (Antineoplastic Enzyme Inhibitor)", + "output": "something described as a small aminothiazole molecule and cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. SNS-032 binds to and prevents the phosphorylation of cyclin-dependent kinases, especially CDK2, 7, and 9 that regulate cell cycle progression. Inhibition of CDKs leads to cell cycle arrest and induces apoptosis. As a result, this agent causes cytotoxicity and prevents further tumor cell growth." + }, + { + "input": "Concept: Cortex intermedius (Region of cerebral cortex)", + "output": "something described as a cytoarchitecturally defined subdivision of the cerebral cortex that is transitional between neocortex and allocortex ( Mesulam-1984 ). In the terminology of ( Stephan-1975 ) it is a composite of proisocortex, which is a subdivision of neocortex, and periallocortex. See also: paralimbic regions." + }, + { + "input": "Concept: Mesangial Proliferative Glomerulonephritis (Kidney)", + "output": "something described as a focal inflammation of glomeruli secondary to mesangial cell proliferation and matrix deposition within the mesangium." + }, + { + "input": "Concept: Iris transillumination defects (Iris pigmentation abnormal)", + "output": "something described as transmission of light through the iris as visualized upon slit lamp examination or infrared iris transillumination videography. The light passes through defects in the pigmentation of the iris." + }, + { + "input": "Concept: Venom, Sea Snake (Snake Venoms)", + "output": "Hazardous or Poisonous Substance described as venoms of sea snakes (HYDROPHIIDAE) found around Pacific islands. The venoms contain fewer enzymes and more neuro- or myotoxins than land snakes. The neurotoxic proteins are similar to elapid small, short, or type I neurotoxins, some of which have been characterized." + }, + { + "input": "Concept: Adhesive Tapes (Healthcare supplies)", + "output": "Adhesives described as tapes coated on one or both sides with an adhesive. Adhesive tapes are usually very long (e.g., several yards/meters) and narrow (typically 0.5 to 3 inches/12 to 76 mm) strips or bands made of materials such as cloth (e.g., cotton), plastic, paper, and/or other materials. Adhesive tapes are intended to attach objects (e.g., dressings, bandages, tubes, catheters) to the body or other surfaces; tape may also be applied in several layers, one overlapping the other (i.e., strapping), to cover and exert pressure on a body part (e.g., a limb). Adhesive tapes with particular properties (e.g., hypoallergenic, waterproof, or both) are also available." + }, + { + "input": "Concept: Prominin (Membrane Glycoproteins)", + "output": "Immunologic Factor described as a member of the prominin family, AC133 Antigen is a 5-transmembrane antigen occurring as several isoforms produced by alternative splicing which are processed into mature forms. In humans, it is expressed as a subset of CD34 (bright) human hematopoietic stem cells and CD34 positive leukemias. Functionally, it is associated with roles in cell differentiation, proliferation, and apoptosis. Specifically, it regulates the organization of apical plasma membrane in epithelial cells, disk morphogenesis during early retinal development, MAPK and Akt signaling pathways, and in cholesterol metabolism." + }, + { + "input": "Concept: Malpighian tubule stellate cell differentiation (epithelial cell differentiation)", + "output": "epithelial cell differentiation described as the process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule stellate cell. A Malpighian tubule stellate cell is a specialized epithelial secretory cell that moves chloride ions and water across the tubule epithelium." + }, + { + "input": "Concept: 10q24.1-q25.1 (Chromosome band)", + "output": "something described as a chromosome band present on 10q" + }, + { + "input": "Concept: Sex Determination by Skeleton (Sex Determination Analysis)", + "output": "Sex Determination Analysis described as validation of the sex of an individual by means of the bones of the SKELETON. It is most commonly based on the appearance of the PELVIS; SKULL; STERNUM; and/or long bones." + }, + { + "input": "Concept: QLES121 (Intellectual Product)", + "output": "something described as quality Of Life Enjoyment And Satisfaction Questionnaire (Q-LES-Q) During the past week how much of the time have you: felt interested in taking care of your appearance (hair, clothing) and personal hygiene (bathing, dressing)?" + }, + { + "input": "Concept: NM 005228.3:c.2310 2311ins9 (Cell or Molecular Dysfunction)", + "output": "something described as an insertion of nine nucleotides, AGCGTGGAC, between position 2310 and 2311 of the coding sequence of the EGFR gene." + }, + { + "input": "Concept: SIQ01-Tell People I Plan to Kill Myself (Intellectual Product)", + "output": "something described as suicidal Ideation Questionnaire (SIQ) I thought about telling people I plan to kill myself." + }, + { + "input": "Concept: paracingulate sulcus (Body Space or Junction)", + "output": "something described as the cingulate sulcus more distant from the corpus callosum in the approximately 35% of humans who have a double cingulate gyrus. This second sulcus parallels the anterior portion of the cingulate sulcus. Like the cingulate sulcus, it may be continuous or interrupted. It forms the outer boundary of the rostral part of the external cingulate gyrus ( Vogt-1995 )." + }, + { + "input": "Concept: RNH (Gene or Genome)", + "output": "something described as this gene plays a role in enzyme inhibition." + }, + { + "input": "Concept: Npl3 (Gene or Genome)", + "output": "something described as human TAF15 wild-type allele is located within 17q11.1-q11.2 and is approximately 38 kb in length. This allele, which encodes TATA-binding protein-associated factor 2N protein, is involved in gene expression. Translocation t(9;17)(q22;q11) involving the TAF15 gene and the NR4A3 gene is associated with extraskeletal myxoid chondrosarcoma." + }, + { + "input": "Concept: Failure to Gain Weight/Thrive (Clinical Attribute)", + "output": "Clinical Attribute described as history of failure to gain weight." + }, + { + "input": "Concept: pT4 Skin Melanoma (Finding)", + "output": "Cutaneous Melanoma Pathologic Primary Tumor TNM Finding v7 described as cutaneous melanoma greater than 4.0 mm in thickness, with or without ulceration." + }, + { + "input": "Concept: Kallikrein Inactivator Unit/Milliliter (Unit of biological and biochemical measurement)", + "output": "Unit of Arbitrary Substance Concentration described as an arbitrary unit of a kallikrein inactivator concentration equal to the concentration at which one milliliter of the mixture contains one unit of the kallikrein inactivator." + }, + { + "input": "Concept: oxidoreduction coenzyme metabolic process (Molecular Function)", + "output": "Molecular Function described as the chemical reactions and pathways involving coenzymes that are required, in addition to an enzyme and a substrate, for an oxidoreductase reaction to proceed." + }, + { + "input": "Concept: Immune Cell (Hematopoietic and Lymphoid Cell)", + "output": "something described as a cell in the immune system that is involved in host defense. This category may include lymphocytes, monocytes, macrophages, neutrophils, eosinophils, basophils, mast cells, and thrombocytes. Precursor cells in these lineages may also be included." + }, + { + "input": "Concept: QCR6 (Gene or Genome)", + "output": "Gene or Genome described as this gene plays a role in the mitochondrial respiratory chain." + }, + { + "input": "Concept: Dexamethasone + neomycin sulphate + polymyxin b sulphate (Organic Chemical)", + "output": "polymyxin B described as a topical combination preparation containing the sulfate salt form of the aminoglycoside antibiotic neomycin, the sulfate salt form of the polypeptide antibiotic polymyxin B, and the glucocorticoid dexamethasone, with antimicrobial, anti-infective and anti-inflammatory activities. Upon topical application, neomycin irreversibly binds to the bacterial 30S ribosomal subunit, thereby preventing mRNA from binding, causing both misreading and the inhibition of protein synthesis. Polymyxin B binds, with its positively charged amino groups, to negatively charged phospholipids in the outer cell membrane of Gram-negative bacteria, thereby disrupting cell wall integrity and altering the permeability of the bacterial cytoplasmic membrane. Dexamethasone binds to the cytoplasmic glucocorticoid receptor, and this receptor-ligand complex is translocated to the nucleus where it initiates the transcription of genes encoding for anti-inflammatory mediators, such as cytokines and lipocortins." + }, + { + "input": "Concept: Has presentation strength denominator unit (Concept model attribute)", + "output": "Qualitative Concept described as this attribute specifies the denominator unit for the presentation strength of a product." + }, + { + "input": "Concept: Congenital Epilepsy (Seizures and seizure disorders NEC)", + "output": "Seizures and seizure disorders NEC described as a seizure disorder that is present at the time of birth." + }, + { + "input": "Concept: LIVEDO ANNULARIS (Disease of Skin and Appendages)", + "output": "Skin Manifestations described as a recurrent purple discoloration of the skin that does not blanche and is found in a lacy, network pattern, most often in the lower extremities. It may be aggravated by exposure to cold and is classified as idiopathic or secondary. Secondary livedo reticularis may be a cutaneous manifestation of immune system disorders (e.g., lupus erythematosus, rheumatoid arthritis, cryoglobulinemia, lymphoma, etc), and hematologic disorders (polycythemia vera)." + }, + { + "input": "Concept: Montserrat (Geographic Area)", + "output": "Lesser Antilles described as a country in the Caribbean, occupying an island in the Caribbean Sea, southeast of Puerto Rico." + }, + { + "input": "Concept: Stratum Intermedium (Tissue)", + "output": "Tissue described as a layer of condensed cells in the developing tooth that is located between the inner enamel epithelium and the stellate reticulum." + }, + { + "input": "Concept: TSCC - Feeling Dizzy (Intellectual Product)", + "output": "something described as trauma Symptom Checklist for Children - Feeling dizzy." + }, + { + "input": "Concept: cross infection (Infections NEC)", + "output": "Infection described as infection associated with hospitalization, not present or incubating prior to admission, but generally occurring more than 72 hours after admission." + }, + { + "input": "Concept: Noninfectious diarrhea (Classification)", + "output": "something described as SMQ Noninfectious diarrhoea is intended to retrieve cases that may be drug related including antibiotic associated diarrhea not caused by Clostridium difficile or other infectious pathogens. Diarrhea defined as: increased frequency of bowel movements (>3 in 24 hours); and/or decreased stool consistency; and/or increased stool weight (>200g in 24 hours). Common side effect of many classes of medications, accounting for a high percentage of all adverse drug effects. Hundreds of drugs have been implicated in causing diarrhea. Most frequent are: antibiotics; laxatives; antihypertensives; lactulose or sorbitol containing products; antineoplastics; antiretroviral drugs; magnesium containing compounds; antiarrhythmics; non-steroidal anti-inflammatory drugs; colchicines; antacids and acid-reducing agents; prostaglandin analogs; and many supplements. Mechanisms of noninfectious diarrhea: non-inflammatory (e.g., osmotic or secretory diarrhea); inflammatory" + }, + { + "input": "Concept: Four Dimensional Echocardiography (Ultrasound procedure on cardiovascular system)", + "output": "Diagnostic Procedure described as dynamic three-dimensional echocardiography using the added dimension of time to impart the cinematic perception of motion." + }, + { + "input": "Concept: Bacteroides endodontalis van Steenbergen et al. 1984 (Bacterium)", + "output": "Bacteroides described as a species of obligately anaerobic, Gram-negative, rod shaped bacteria assigned to the phylum Bacteroidetes. This species is nonmotile, non-spore forming, indole positive, alpha-fucosidase, trypsin, and catalase negative, liquefies gelatin, produces hydrogen sulfide, utilizes trypticase, proteose, and peptone as energy sources, nonfermenting, pigmented, and does not reduce nitrate or hydrolyze starch or esculin. P. endodontalis is associated with periodontal disease." + }, + { + "input": "Concept: wound healing involved in inflammatory response (Organism Function)", + "output": "Wound Healing described as the series of events that restore integrity to damaged tissue that contribute to an inflammatory response." + }, + { + "input": "Concept: Topoisomerase (Enzyme)", + "output": "Amino Acid, Peptide, or Protein described as enzymes that change the degree of supercoiling in DNA by cutting one or both strands. Type I topoisomerases cut only one strand of DNA; type I topoisomerase of E. coli (omega protein) relaxes negatively supercoiled DNA and does not act on positively supercoiled DNA. Type II topoisomerases cut both strands of DNA; type II topoisomerase of E. coli (DNA gyrase) increases the degree of negative supercoiling in DNA and requires ATP. It is inhibited by several antibiotics, including nalidixic acid and ovobiocin." + }, + { + "input": "Concept: Abnormal sperm motility (Infertility study)", + "output": "Finding described as an anomaly of the mobility of ejaculated sperm." + }, + { + "input": "Concept: Agrimony, Bach flower essence (Pharmacologic Substance)", + "output": "Flower Essences described as agrimony." + }, + { + "input": "Concept: cyanuric acid amidohydrolase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides)", + "output": "something described as catalysis of the reaction: cyanuric acid + H2O = biuret + CO2." + }, + { + "input": "Concept: window (Conceptual Entity)", + "output": "Conceptual Entity described as a part of a computer screen that contains a display different from the rest of the screen." + }, + { + "input": "Concept: WD5D1 2 (Intellectual Product)", + "output": "something described as world Health Organization Disability Assessment Schedule 2.0 - 36-Item Interviewer - In the past 30 days, how much difficulty did you have in: Remembering to do important things?" + }, + { + "input": "Concept: Inflammation, Nerve Root (Lesions of nerves plexuses and roots)", + "output": "spinal symptom and disorder described as an inflammatory process affecting a nerve root. Patients experience pain radiating along a nerve path because of spinal pressure on the nerve root that connects to the nerve path." + }, + { + "input": "Concept: LEAD aVF (Electrocardiograph lead site)", + "output": "something described as an augmented unipolar electrocardiogram limb lead in which the positive (red) electrode is situated on the left pelvic limb and the negative electrode is a combination of the right thoracic limb (white) electrode and the left thoracic limb (black) electrode. Measures the electrical activity of the electrode on the left pelvic limb." + }, + { + "input": "Concept: Causality Assessment (Health Care Activity)", + "output": "something described as a medical determination about the likely connection between an adverse event and a treatment or product being studied." + }, + { + "input": "Concept: ESRD (Chronic Kidney Insufficiency)", + "output": "Disease or Syndrome described as chronic, irreversible renal failure." + }, + { + "input": "Concept: Fine-needle biopsy (Surgical extraction)", + "output": "Procedure categorized by device involved described as using fine needles (finer than 22-gauge) to remove tissue or fluid specimens from the living body for examination in the pathology laboratory and for disease diagnosis." + }, + { + "input": "Concept: HYDROmorphone Hydrochloride (Central depressant)", + "output": "hydromorphone described as the hydrochloride salt of the semi-synthetic opioid hydromorphone with analgesic activity. Hydromorphone, the hydrogenated ketone of morphine, selectively binds the mu-opioid receptor, a G protein-coupled receptor. Binding stimulates the exchange of guanosine triphosphate (GTP) for guanosine diphosphate (GDP) on the G-protein complex, resulting in inhibition of plasma membrane-associated adenylate cyclase (AC) and a reduction in intracellular cyclic 3',5'-adenosine monophosphate (cAMP) levels. Due to a reduction in cAMP levels, voltage-gated potassium channels are activated, resulting in neuronal hyperpolarization and a reduction in neuronal excitability. In addition, this agent inhibits the opening of voltage-gated calcium channels, resulting in inhibition of calcium entry into neuronal cells and a reduction in the release of nociceptive neurotransmitters such as substance P and glutamate. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C436\" active clinical trials using this agent." + }, + { + "input": "Concept: Polyarticular arthritis (Polyarthropathy)", + "output": "Synovitis described as inflammation of several joints together." + }, + { + "input": "Concept: OABQ0217 (Intellectual Product)", + "output": "something described as the Overactive Bladder Questionnaire Short Form (OAB-q Short Form) Interfered with getting the amount of sleep you needed?" + }, + { + "input": "Concept: padeliporfin (Photosensitizing Agents)", + "output": "Amino Acid, Peptide, or Protein described as a vascular-acting photosensitizer consisting of a water-soluble, palladium-substituted bacteriochlorophyll derivative with potential antineoplastic activity. Upon administration, paldeliporfin is activated locally when the tumor bed is exposed to low-power laser light; reactive oxygen species (ROS) are formed upon activation and ROS-mediated necrosis may occur at the site of interaction between the photosensitizer, light and oxygen. Vascular-targeted photodynamic therapy (VTP) with padeliporfin may allow tumor-site specific cytotoxicity while sparing adjacent normal tissues." + }, + { + "input": "Concept: 15q21.1 (Cell Component)", + "output": "Chromosome band described as a chromosome band present on 15q" + }, + { + "input": "Concept: Meningioma of Anterior Foramen Magnum (Neoplastic Process)", + "output": "Neoplastic Process described as a meningioma that affects the anterior foramen magnum." + }, + { + "input": "Concept: cDNA Microarray (DNA Microarray format)", + "output": "Research Activity described as complementary DNA (cDNA) clone inserts robotically printed onto a glass slide and subsequently hybridized to two differentially fluorescently labeled probes. The probes are pools of cDNAs, which are generated after isolating mRNA from cells or tissues in two states that one wishes to compare." + }, + { + "input": "Concept: Mitral valve atresia (Congenital Abnormality)", + "output": "Abnormal mitral valve morphology described as a congenital defect with failure to open of the mitral valve orifice." + }, + { + "input": "Concept: Chemical Conjugation (Physical Phenomenon or Property)", + "output": "Physical Phenomenon or Property described as the formation of one or more covalent or non-covalent links between two or more chemical compounds." + }, + { + "input": "Concept: determination of left/right asymmetry in nervous system (Organism Function)", + "output": "Organism Function described as the establishment of the nervous system with respect to the left and right halves." + }, + { + "input": "Concept: gp100:17-25 Peptide (Vaccines, Peptide)", + "output": "Immunologic Factor described as a synthetic peptide vaccine consisting of amino acids 17 through 25 of the glycoprotein 100 (gp100) melanoma antigen. Vaccination with gp100_17-25 may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for gp100, resulting in decreased tumor growth." + }, + { + "input": "Concept: lateral line nerve glial cell morphogenesis involved in differentiation (cell morphogenesis involved in differentiation)", + "output": "Cell Function described as the process in which the structure of a glial cell in a lateral line nerve is generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in a lateral line nerve." + }, + { + "input": "Concept: Heater/Cooler Units (Medical Device)", + "output": "Medical Device described as units designed to regulate a patient's temperature by heating or cooling. These units usually include a central system with heating and refrigerating capabilities, controls, alarms, and some means (e.g., blankets) to deliver thermal changes to the patient. Patient warming/cooling units are used to warm patients who are hypothermic, to maintain normal body temperature during and after surgery, to cool feverish patients, or to induce hypothermia to lower metabolism (e.g., during cardiac surgery, neurosurgery)." + }, + { + "input": "Concept: eucalyptus (Myrtaceae)", + "output": "something described as a genus of trees of the Myrtaceae family, native to Australia, that yields gums, oils, and resins which are used as flavoring agents, astringents, and aromatics." + }, + { + "input": "Concept: canonical Wnt signaling pathway involved in stem cell proliferation (Cell Function)", + "output": "Cell Function described as any canonical Wnt signaling pathway that is involved in stem cell proliferation." + }, + { + "input": "Concept: bone marrow cell proliferation (cell population proliferation)", + "output": "cell population proliferation described as the multiplication or reproduction of cells, resulting in the expansion of a cell population in the bone marrow." + }, + { + "input": "Concept: Feeling bilious (Functions and Abnormal Functions of the Stomach)", + "output": "Renal function described as distaste for food/fluid and an urge to vomit" + }, + { + "input": "Concept: positive regulation of macromolecule metabolic process (positive regulation of metabolic process)", + "output": "regulation of macromolecule metabolic process described as any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." + }, + { + "input": "Concept: Non-Invasive Pancreatic Mucinous Cystic Neoplasm (Pancreatic Mucinous-Cystic Neoplasm)", + "output": "something described as a cystic epithelial neoplasm characterized by the presence of columnar mucin-producing epithelial cells, ovarian-type stroma formation, and the absence of an invasive carcinomatous component." + }, + { + "input": "Concept: ANTISERUM, POSITIVE CONTROL, COCCIDIOIDES IMMITIS (Indicator, Reagent, or Diagnostic Aid)", + "output": "Indicator, Reagent, or Diagnostic Aid described as coccidioides immitis serological reagents are devices that consist of antigens and antisera used in serological tests to identify antibodies to Coccidioides immitis in serum. The identification aids in the diagnosis of coccidioidomycosis caused by a fungus belonging to the genus Coccidioides and provides epidemiological information on diseases caused by this microorganism. An infection with Coccidioides immitis produces symptoms varying in severity from those accompanying the common cold to those of influenza." + }, + { + "input": "Concept: CSS10-Most Severe Idea-Life (Intellectual Product)", + "output": "C-SSRS Pediatric Cognitively Impaired Lifetime Recent Questionnaire Question described as columbia-Suicide Severity Rating Scale Pediatric/Cognitively Impaired Lifetime/Recent - Most severe ideation. (Lifetime)." + }, + { + "input": "Concept: renal interstitial fibroblast fate commitment (cell fate commitment)", + "output": "something described as the process in which the developmental fate of a cell becomes restricted such that it will develop into a renal fibroblast." + }, + { + "input": "Concept: New York Heart Association Class IV (New York Heart Association Class)", + "output": "Finding described as inability to carry on any physical activity without discomfort. Heart failure symptoms are present even at rest or with minimal exertion." + }, + { + "input": "Concept: Storage Pool Platelet Disease (Hematology)", + "output": "Qualitative platelet disorder described as disorder characterized by a decrease or lack of platelet dense bodies in which the releasable pool of adenine nucleotides and 5HT are normally stored." + }, + { + "input": "Concept: Bowman-Birk Inhibitor Concentrate (Protease Inhibitors)", + "output": "Pharmacologic Substance described as an extract of soybeans enriched in Bowman-Birk inhibitor (BBI), a soybean-derived, 71-amino acid, polypeptide and serine protease inhibitor with potential chemopreventive activity. Bowman-Birk inhibitor contains distinct inhibitory sites for trypsin and chymotrypsin. Although the exact mechanism by which BBI suppresses carcinogenesis is unknown, its antiproliferative activity appears to be linked to the chymotrypsin inhibitory region. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C48381\" active clinical trials using this agent." + }, + { + "input": "Concept: CTCAE Grade 1 AV Block-Second degree Mobitz Type I (Mobitz Type I, CTCAE)", + "output": "something described as asymptomatic, intervention not indicated" + }, + { + "input": "Concept: Deficiency Disease, Complete HGPRT (Mental Retardation)", + "output": "Brain Diseases, Metabolic, Inborn described as an inborn error of metabolism resulting from a deficiency of hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) with increased conversion of glycine to uric acid with excessive purine synthesis and hyperuricemia. Patients are normal at birth but begin to show hypertonicity at about 4 months and irritability and other neurological symptoms become apparent during the second year of life, the child becoming gradually more aggressive and self-destructive, banging his head, biting the lower lip and, less commonly, the upper lip, cheeks, fingers, and hands, sometimes using the fingers to mutilate his ears and nose. Associated disorders include spastic cerebral palsy, choreoathetosis, renal uric acid calculi, gouty tophi, and uric acid nodules. Mental retardation is common but normal intelligence occurs in some cases." + }, + { + "input": "Concept: CDISC Functional Test 4 Stair Ascend Test Code Terminology (CDISC Functional Test Terminology)", + "output": "Intellectual Product described as 4 Stair Ascend test code." + }, + { + "input": "Concept: epiboly involved in wound healing (Organ or Tissue Function)", + "output": "something described as the expansion of one cell sheet over other cells involved in wound healing." + }, + { + "input": "Concept: Sensitivity-Modulating Protein (Serology)", + "output": "Immunologic Factor described as a neuronal calcium-sensor protein that is found in ROD PHOTORECEPTORS and CONE PHOTORECEPTORS. It interacts with G-PROTEIN-COUPLED RECEPTOR KINASE 1 in a Ca2+ dependent manner and plays an important role in PHOTOTRANSDUCTION." + }, + { + "input": "Concept: Solanum dulcamaras (Plant)", + "output": "genus Solanum described as bittersweet, deadly nightshade." + }, + { + "input": "Concept: No Vascular Invasion (Physical shape)", + "output": "something described as an indication that signs of vascular invasion have not been found in a sample." + }, + { + "input": "Concept: Exploration procedure [dup] (Evaluation procedure)", + "output": "Clinical actions A - G described as an observation of the body or a body part done by inspection and/or palpation" + }, + { + "input": "Concept: RING7 (HLA-DMB gene)", + "output": "HLA-DMB gene described as human HLA-DMB wild-type allele is located in the vicinity of 6p21.32 and is approximately 6 kb in length. This allele, which encodes HLA class II histocompatibility antigen, DM beta chain protein, plays a role in facilitating the presentation of antigenic peptides." + }, + { + "input": "Concept: Safety-net Provider (Health Care Activity)", + "output": "Health Care Activity described as providers that by mandate or mission organize and deliver a significant level of health care and other health-related services to the uninsured, Medicaid recipients, and other vulnerable patients." + }, + { + "input": "Concept: Documentation Present (CPTAC Responses)", + "output": "Finding described as documentation is present." + }, + { + "input": "Concept: IKZF3 gene (Gene or Genome)", + "output": "Transcription factor genes described as this gene plays a role in both transcription in hematopoietic cells and lymphocyte development." + }, + { + "input": "Concept: problems with breastfeeding (Nutritional Component)", + "output": "Breast function described as diminished ability to nourish infant at the breast" + }, + { + "input": "Concept: sucrose catabolic process (sucrose metabolic process)", + "output": "disaccharide catabolic process described as the chemical reactions and pathways resulting in the breakdown of sucrose, the disaccharide fructofuranosyl-glucopyranoside." + }, + { + "input": "Concept: Incus structure (Body Part, Organ, or Organ Component)", + "output": "middle ear described as one of three ossicles of the middle ear. It conducts sound vibrations from the MALLEUS to the STAPES." + }, + { + "input": "Concept: Alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory Questionnaire Test Code (CDISC Questionnaire Terminology)", + "output": "CDISC Questionnaire Terminology described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory test code." + }, + { + "input": "Concept: Internalizing Problems Composite (Intellectual Product)", + "output": "something described as a composite score of the Behavior Assessment System for Children that combines the anxiety, depression, and somatization scales. This composite measures a broad index of distress that reflects the clinical, internalizing problems a child may be experiencing." + }, + { + "input": "Concept: Inhibition Test, Hemagglutination (agglutination)", + "output": "Immunology procedure described as serologic tests in which a known quantity of antigen is added to the serum prior to the addition of a red cell suspension. Reaction result is expressed as the smallest amount of antigen which causes complete inhibition of hemagglutination." + }, + { + "input": "Concept: Error Analysis (Statistical Reliability & Validity)", + "output": "something described as collection, classification, and/or analysis of mistakes, especially in task or test performance." + }, + { + "input": "Concept: Shamanic extraction each 15 minutes (Shamanism)", + "output": "something described as using shamanic techniques to heal a client's emotional, physical and/or spiritual imbalance(s). Any practitioner using this code must document appropriate training and/or certification. Service is billed in 15-minute increments." + }, + { + "input": "Concept: Pan-RAR Agonist/AP-1 Inhibitor LGD 1550 (Retinoids)", + "output": "Pharmacologic Substance described as an orally-active synthetic aromatic retinoic acid agent with potential antineoplastic and chemopreventive activities. LGD 1550 selectively binds to all three retinoic acid receptors (RAR-alpha, RAR-beta, and RAR-gamma), resulting in alterations in the expression of genes responsible for cell differentiation and proliferation. This agent also acts as an inhibitor of activator protein 1 (AP-1), a protein that mediates trophic responses and malignant transformation." + }, + { + "input": "Concept: ESRS-A - CGI-S Akathisia (Intellectual Product)", + "output": "Intellectual Product described as extrapyramidal Symptom Rating Scale-Abbreviated (ESRS-A) Clinical Global Impression (CGI-S): Akathisia." + }, + { + "input": "Concept: regulation of TORC1 signal transduction (regulation of TOR signaling)", + "output": "Molecular Function described as any process that modulates the frequency, rate or extent of TORC1 signaling." + }, + { + "input": "Concept: Superior Vena Cava Leiomyosarcoma (Malignant Superior Vena Cava Neoplasm)", + "output": "something described as an aggressive malignant smooth muscle neoplasm, arising from the superior vena cava. It is characterized by a proliferation of neoplastic spindle cells." + }, + { + "input": "Concept: histone methyltransferase DOT1L (Methyltransferase Gene)", + "output": "Methyltransferase Gene described as this gene is involved in epigenetic control of gene expression." + }, + { + "input": "Concept: Imaging Accession Identifier (Intellectual Product)", + "output": "Intellectual Product described as a control number unique to an image and used to identify the object among other images in a collection." + }, + { + "input": "Concept: regulation of lymphocyte migration (regulation of leukocyte migration)", + "output": "regulation of leukocyte migration described as any process that modulates the frequency, rate or extent of lymphocyte migration." + }, + { + "input": "Concept: CAMP PROTEIN KINASES (Enzyme)", + "output": "something described as most cellular effects of cAMP are mediated through PKA by serine or threonine phosphorylation of target proteins. Human Protein Kinase A (cAMP Ser/Thr Protein Kinase Family) is an inactive tetrameric cytoplasmic holoenzyme composed of homo- or heterodimeric regulatory subunits associated with two catalytic subunits. cAMP causes dissociation of inactive holoenzyme into a cAMP-bound dimer of regulatory subunits and two free monomeric catalytic subunits that phosphorylate many cytoplasmic and nuclear substrates. In human, regulatory PRKAR1A, PRKAR1B, PRKAR2A, and PRKAR2B subunits and catalytic PRKACA, PRKACB, and PRKACG subunits have been identified." + }, + { + "input": "Concept: Fresh (Biospecimen)", + "output": "Body Substance described as a specimen that is analyzed in the state that it was collected." + }, + { + "input": "Concept: Daily Vaper (Current Vaper)", + "output": "Finding described as a person who uses a vaping device at least once every day." + }, + { + "input": "Concept: mitotic cell cycle, embryonic (Mitotic Cell Cycle)", + "output": "Mitotic Cell Cycle described as the eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo." + }, + { + "input": "Concept: Likert Score 0 (Intellectual Product)", + "output": "Intellectual Product described as a subjective score of 0 on a Likert scale." + }, + { + "input": "Concept: Angiocentric glioma (Glioma, uncertain whether benign or malignant)", + "output": "Neoplastic Process described as a WHO grade I, slow-growing brain neoplasm of children and young adults, associated with epilepsy. Morphologically it is characterized by an angiocentric pattern, monomorphic cellular infiltrate, and ependymal differentiation." + }, + { + "input": "Concept: PQL1606 (PedsQL Neuromuscular Module Acute Version 3.0 Young Child Report Questionnaire Question)", + "output": "PedsQL Neuromuscular Module Acute Version 3.0 Young Child Report Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Acute Version 3 Young Child - Think about how you have been doing for the past 7 days. Please listen carefully to each sentence and tell me how much of a problem this is for you: My back feels stiff." + }, + { + "input": "Concept: ventromedial preoptic nucleus (Body Part, Organ, or Organ Component)", + "output": "Body Part, Organ, or Organ Component described as a group of cells located in the preoptic area of the mouse ( Paxinos-2001 )." + }, + { + "input": "Concept: Ionomycin (Fatty Acids, Unsaturated)", + "output": "something described as a polyether antibiotic isolated from Streptomyces conglobatus sp. nov. Trejo with antineoplastic activity. Ionomycin is a calcium ionophore that increases intracellular Ca++ levels, possibly relating to endonuclease activation of lymphocytes and decreased ratio of Bcl-2 to Bax and ultimately apoptosis. In addition, this agent is used to investigate the role of intracellular calcium in cellular processes." + }, + { + "input": "Concept: RNA Interference Pathway (Genetic Function)", + "output": "Genetic Function described as about 8% of human genes have been estimated to carry out transcription from both DNA strands, resulting in significant level of endogenous antisense RNA. In the cytoplasm the antisense RNA leads to formation of long dsRNA, which activates the interferon and RNA-dependent protein kinase antiviral pathway. Most endogenous antisense RNA is made in the nucleus and two responses have been suggested for the nuclear dsRNA. First, the dsRNA may be processed by enzymes of the family of adenosine deaminases that act on RNA (ADAR). The deaminated dsRNAs contain various levels of inosines. dsRNA containing high level of inosines are tightly bound by a protein complex that results in their nuclear retention. dsRNA containing low level of inosines may be able to exit the nucleus. Second, the nuclear dsRNA can lead to gene silencing and heterochromatin formation." + }, + { + "input": "Concept: Contrast Agent Name (Name)", + "output": "Indicator, Reagent, or Diagnostic Aid described as contrast or bolus agent." + }, + { + "input": "Concept: Report Generation (Functional Concept)", + "output": "Functional Concept described as the act of bringing a report into being." + }, + { + "input": "Concept: Fragments, Peptide (Peptides)", + "output": "something described as partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques." + }, + { + "input": "Concept: hemocyte differentiation (Organ or Tissue Function)", + "output": "Immune System Processes described as the process in which a relatively unspecialized cell acquires the characteristics of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." + }, + { + "input": "Concept: Skin neoplasms, malignant and unspecified (Classification)", + "output": "Classification described as SMQ developed to detect all types of malignant and unspecified tumors related to the skin. It covers all types of malignant and unspecified neoplasms related to skin; also: malignancy related conditions (specific for skin); malignancy related therapeutic procedures (specific for skin); malignancy related diagnostic procedures (specific for skin). Includes two sub-search SMQs - one for malignant tumors and one for tumors of unspecified malignancy." + }, + { + "input": "Concept: Dilated Anus (Finding During Childbirth Labor)", + "output": "Sign or Symptom described as a characteristic sign of impending birth where the anal opening becomes wider due to increased pressure in the perineal region during the second stage of labor." + }, + { + "input": "Concept: bisantrene (Organic Chemical)", + "output": "Anthraquinones described as an anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity." + }, + { + "input": "Concept: Tryptase measurement (Protein or Enzyme Type Measurement)", + "output": "Protein or Enzyme Type Measurement described as the determination of the amount of tryptase present in a sample." + }, + { + "input": "Concept: Wechsler Preschool and Primary Scale of Intelligence (Intellectual Product)", + "output": "Intelligence Scale described as an intelligence test published by Harcourt Assessment and designed for children ages 2 years 6 months to 7 years 3 months. It provides subtest and composite scores that represent intellectual functioning in verbal and performance cognitive domains, and provides a composite score that represents a child's general intellectual ability." + }, + { + "input": "Concept: Scanning Systems, Ultrasonic, Vascular (Scanning Systems, Ultrasonic)", + "output": "something described as ultrasonic scanning systems that include an ultrasonic scanner, transducers (frequencies of 5 to 12 MHz are typical for vascular scanning), dedicated software, an image recorder (e.g., videocassette), and a printer. Most vascular ultrasonic scanners include continuous-wave and pulsed-wave Doppler capabilities (including a spectrum analyzer) for sensing the velocity and location of blood flow; they can be operated in mode, color flow mapping mode, and triplex mode (i.e., simultaneous acquisition and display of 2-D gray-scale, spectral Doppler, and color flow data). Vascular ultrasonic scanning systems usually display images of the vessels in conjunction with spectrum analysis to depict the vessel and its obstructions. Some vascular scanners use a low-frequency (typically 2 MHz) Doppler transducer to obtain the blood flow velocity recording in the intracranial arteries. These systems are used for transdermal examination and diagnosis of diseases, occlusions, and obstructions in the peripheral vascular system, including a profile of the blood-flow velocity in the area under examination. Most of them also include capabilities for small-part examinations." + }, + { + "input": "Concept: cell wall thickening (Cell Function)", + "output": "something described as a type of cell wall modification in which the cell wall is reinforced and made thicker." + }, + { + "input": "Concept: intermediolateral visual area (Visual Cortex - rodent)", + "output": "Body Location or Region described as one of ten visual areas in the rat ( Swanson-2004 ). See visual cortex (rodent). \\r\\n" + }, + { + "input": "Concept: Intraventricular hemorrhage neonatal (Finding)", + "output": "something described as bleeding into the lateral cerebral ventricles in a newborn infant." + }, + { + "input": "Concept: beta Aminoisobutyric acid (Amino Acids)", + "output": "Aminoisobutyric Acids described as a derivative of the amino acid alanine that is a product of thymine metabolism, which has the potential to induce downstream metabolic activity. During exercise, 3-aminoisobutyric acid is secreted by muscle cells into the blood. Once this molecule interacts with adipocytes, it may induce signaling pathways that regulate the metabolism of fats, insulin, and cholesterol." + }, + { + "input": "Concept: Actinomycin C2 (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as a natural analogue of actinomycin, a chromopeptide antineoplastic antibiotic isolated from the bacterial genus Streptomyces. Actinomycin C2 inhibits DNA replication as well as RNA and protein synthesis by various mechanisms including, intercalating into the minor groove of DNA and interfering with the function of topoisomerase II. In addition, actinomycin C2 appears to block the interaction between the SH2 domain of growth factor receptor-bound protein-2 (GRB2) and the Src homology 2 domain containing transforming protein 1 adaptor protein SHC, which plays a key role in the Ras signaling pathway thereby halting cellular differentiation and proliferation." + }, + { + "input": "Concept: Cystine/Glutamate Transporter (Carrier Proteins)", + "output": "Carrier Proteins described as cystine/glutamate transporter protein (501aa, ~55 kDa) is encoded by the human SLC7A11 gene. This protein is involved in the exchange of anionic amino acids and has a high specificity for anionic forms of cystine and glutamate. The protein has been identified as a method of entry utilized by the Karposi's sarcoma herpesvirus to gain entry into the cell. The virus plays an essential role in the pathogenesis of Karposi's sarcoma and certain types of lymphoma." + }, + { + "input": "Concept: Perineal Heat Lamps (Lights, manufactured)", + "output": "Medical Device described as a perineal heater is a device designed to apply heat directly by contact, or indirectly from a radiant source, to the surface of the perineum (the area between the vulva and the anus) and is used to soothe or to help heal the perineum after an episiotomy (incision of the vulvar orifice for obstetrical purposes)." + }, + { + "input": "Concept: Prostaglandin D2 (Laboratory Procedure)", + "output": "Prostaglandin measurement described as the determination of the amount of the prostaglandin D2 in a sample." + }, + { + "input": "Concept: Closed capsulotomy (Therapeutic procedure)", + "output": "Therapeutic or Preventive Procedure described as a procedure used to treat capsular contraction that uses physical manipulation of the breast to manually rupture scar tissue and release pressure on an implant." + }, + { + "input": "Concept: Grade 3 Hemolytic Uremic Syndrome, CTCAE (Finding)", + "output": "something described as laboratory findings with clinical consequences" + }, + { + "input": "Concept: Infantile apnea (Finding)", + "output": "something described as cessation of air flow." + }, + { + "input": "Concept: Manages physiological parameters (Therapeutic or Preventive Procedure)", + "output": "Physiologic Responses described as acquires, interprets, and synthesizes physiological data (e.g., intake and output, hemodynamic status, SaO) to detect and prevent potential adverse clinical events." + }, + { + "input": "Concept: Heterophyes heterophyes infection (Infection by Heterophyes heterophyes)", + "output": "Disease due to Heterophyidae described as an infection that is caused by the intestinal fluke Heterophyes heterophyes, which is most commonly found in Asia, the Middle East, and Africa, and which is transmitted via consumption of contaminated raw or undercooked fish. Symptoms typically range from asymptomatic to intermittent abdominal pain and diarrhea, with occasional ectopic infection." + }, + { + "input": "Concept: Decreased platelet P2Y12 receptor (Abnormal platelet membrane protein expression)", + "output": "Abnormal platelet membrane protein expression described as decreased cell membrane concentration of P2Y12 receptor." + }, + { + "input": "Concept: dental health surveys (Public Health Dentistry)", + "output": "Health Surveys described as a systematic collection of factual data pertaining to dental or oral health and disease in a human population within a given geographic area." + }, + { + "input": "Concept: gastrointestinal system neuroendocrine neoplasm (Malignant neoplasm of gastrointestinal tract)", + "output": "Malignant neoplasm of gastrointestinal tract described as a neoplasm with neuroendocrine differentiation arising from the gastrointestinal system. It includes neuroendocrine tumors (well-differentiated endocrine tumors or carcinoid tumors and well differentiated endocrine carcinomas) and neuroendocrine carcinomas (poorly differentiated neuroendocrine carcinomas, small cell carcinomas, and large cell neuroendocrine carcinomas). Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C27721\" active clinical trials using this agent." + }, + { + "input": "Concept: Nausea and Vomiting during the first 24 hours after chemotherapy (Nausea and vomiting)", + "output": "Finding described as nausea and vomiting occurring during the first 24 hours following chemotherapy." + }, + { + "input": "Concept: FAC10095 (Intellectual Product)", + "output": "FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question described as functional Assessment of Chronic Illness Therapy-Dyspnea Scale 33 Item Bank - Functional Limitation: Considering your shortness of breath over the past 7 days, rate the amount of difficulty you had when doing the following activities: Moderate-intensity leisure activity (bicycling on level terrain, etc.)." + }, + { + "input": "Concept: L-galactono-1,4-lactone:ferricytochrome-c oxidoreductase activity (Molecular Function)", + "output": "oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor described as catalysis of the reaction: L-galactono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c." + }, + { + "input": "Concept: Blue, Tetrabromophenol (toluene)", + "output": "Tosyl Compounds described as a dye that has been used as an industrial dye, a laboratory indicator, and a biological stain." + }, + { + "input": "Concept: Speckled calcifications in end part of pinky finger bone (Epiphyseal stippling of finger phalanges)", + "output": "Anatomical Abnormality described as the presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 5th finger." + }, + { + "input": "Concept: NPI1E10 (NPI Questionnaire Question)", + "output": "Intellectual Product described as neuropsychiatric Inventory (NPI) Anxiety: How emotionally distressing do you find this behavior?" + }, + { + "input": "Concept: ALPHA LIPOIC ACID (Vitamin)", + "output": "Antioxidants described as a substance that is being studied for its ability to protect normal cells from the side effects of chemotherapy and prevent peripheral neuropathy (numbness, tingling, burning, and weakness in the hands or feet). Alpha-lipoic acid is made by the body and can be found in foods such as organ meats, spinach, broccoli, peas, brussel sprouts, and rice bran. It can also be made in the laboratory. Alpha-lipoic acid is a type of antioxidant and chemoprotective agent." + }, + { + "input": "Concept: ovarian follicles (Female internal genitalia structure)", + "output": "Female Reproductive System Part described as an OOCYTE-containing structure in the cortex of the OVARY. The oocyte is enclosed by a layer of GRANULOSA CELLS providing a nourishing microenvironment (FOLLICULAR FLUID). The number and size of follicles vary depending on the age and reproductive state of the female. The growing follicles are divided into five stages: primary, secondary, tertiary, Graafian, and atretic. Follicular growth and steroidogenesis depend on the presence of GONADOTROPINS." + }, + { + "input": "Concept: MMP-X2 (MMP16 gene)", + "output": "Gene or Genome described as human MMP16 wild-type allele is located in the vicinity of 8q21.3 and is approximately 296 kb in length. This allele, which encodes matrix metalloproteinase-16 protein, is involved in endoproteolysis." + }, + { + "input": "Concept: A/G mispair binding (mismatched DNA binding)", + "output": "something described as interacting selectively and non-covalently with double-stranded DNA containing an A/G mispair." + }, + { + "input": "Concept: Fetal Pathology Findings Supplemental Qualifiers Dataset (Intellectual Product)", + "output": "Intellectual Product described as a dataset containing supplemental information, specifically non-standard variables, to parent records in the fetal pathology findings domain." + }, + { + "input": "Concept: Cbp/p300-Interacting Transactivator 2 (Amino Acid, Peptide, or Protein)", + "output": "something described as cbp/p300-interacting transactivator 2 (270 aa, ~28 kDa) is encoded by the human CITED2 gene. This protein plays a role in the positive regulation of gene expression." + }, + { + "input": "Concept: positive regulation of DNA repair (Genetic Function)", + "output": "something described as any process that activates or increases the frequency, rate or extent of DNA repair." + }, + { + "input": "Concept: host Golgi apparatus (Cell Component)", + "output": "something described as a compound membranous cytoplasmic organelle of eukaryotic host cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack." + }, + { + "input": "Concept: up-regulation of H+-transporting ATP synthase activity (positive regulation of cation channel activity)", + "output": "regulation of proton-transporting ATP synthase activity, rotational mechanism described as any process that activates or increases the frequency, rate or extent of proton-transporting ATP synthase activity, rotational mechanism." + }, + { + "input": "Concept: SIGNAL PEPTIDE-, CUB DOMAIN-, AND EGF-LIKE DOMAINS-CONTAINING PROTEIN 2 (Genes, Regulator)", + "output": "something described as this gene may be involved in both cell proliferation and cell-cell adhesion." + }, + { + "input": "Concept: 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone (Dietary Cholesterol Absorption Inhibitor [EPC])", + "output": "Azetidine derivative described as an azetidine derivative and ANTICHOLESTEREMIC AGENT that inhibits intestinal STEROL absorption. It is used to reduce total CHOLESTEROL; LDL CHOLESTEROL, and APOLIPOPROTEINS B in the treatment of HYPERLIPIDEMIAS." + }, + { + "input": "Concept: Vibrio cholerae biovar proteus (Vibrio species a-m)", + "output": "something described as any bacterial organism that can be assigned to the species Vibrio metschnikovii." + }, + { + "input": "Concept: binaural hearing (Hearing)", + "output": "Hearing described as perception of a sound by stimulation of two ears; pertaining to sound that reaches the listener over two paths, to give the effect of auditory perspective; useful in locating source and direction of sound." + }, + { + "input": "Concept: Eye Cancers, Retinoblastoma (Neuroendocrine Tumors)", + "output": "something described as a neuroblastoma arising from the retina." + }, + { + "input": "Concept: negative regulation of c-di-GMP signaling (Cell Function)", + "output": "regulation of c-di-GMP signaling described as any process that decreases the rate, frequency or extent of c-di-GMP signaling." + }, + { + "input": "Concept: benzylpenicillin metabolic process (Molecular Function)", + "output": "penicillin metabolic process described as the chemical reactions and pathways involving benzylpenicillin." + }, + { + "input": "Concept: 1,4-dihydro-7-(3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid (Pharmacologic Substance)", + "output": "Quinolone Antibiotic described as a small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication. As a result, inhibition of DNA replication, RNA and protein synthesis occurs, followed by cell cycle arrest at G2 phase and induced p53-independent apoptosis. This agent shows a favorable toxicity profile in several aspects: it does not generate reactive oxygen species, as do anthracyclines, hence reducing the risk of cardiotoxicity; it is not a P-glycoprotein (P-gp) substrate, and thereby evades the common mechanism for multidrug resistance; and it has limited distribution to normal tissues and a more chemically stable molecular structure. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C95148\" active clinical trials using this agent." + }, + { + "input": "Concept: adult T-cell leukemia/lymphoma - in relapse (Recurrent Aggressive Adult Non-Hodgkin Lymphoma)", + "output": "Recurrent Mature T- Cell and NK-Cell Non-Hodgkin Lymphoma described as the reemergence of adult T-cell leukemia/lymphoma after a period of remission" + }, + { + "input": "Concept: DIBENZ(A,H)ANTHRACENE (Carcinogenic Polycyclic Aromatic Hydrocarbon)", + "output": "Carcinogenic Polycyclic Aromatic Hydrocarbon described as a crystalline, carcinogenic aromatic hydrocarbon consisting of five fused benzene rings, produced by the incomplete combustion of organic matter. Dibenzo(a,h)anthracene is primarily found in gasoline exhaust, tobacco smoke, coal tar, soot and certain food products, especially smoked and barbecued foods. This substance is used only for research purposes to induce tumorigenesis. Dibenzo(a,h)anthracene is a mutagen and is reasonably anticipated to be a human carcinogen." + }, + { + "input": "Concept: K24 Mechanism (Governmental or Regulatory Activity)", + "output": "something described as to provide support to mid-career health-professional doctorates or equivalent who are typically at the Associate Professor level or the equivalent for protected time to devote to patient-oriented research and to act as research mentors primarily for clinical residents, clinical fellows and/or junior clinical faculty." + }, + { + "input": "Concept: SSCAM (Gene or Genome)", + "output": "MAGI2 gene described as human MAGI2 wild-type allele is located in the vicinity of 7q21 and is approximately 1436 kb in length. This allele, which encodes membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2, is involved in the modulation of synaptic receptor localization." + }, + { + "input": "Concept: Macromolecular Substances (Swedish translation of the Medical Subject Headings)", + "output": "French translation of the Medical Subject Headings described as compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure." + }, + { + "input": "Concept: Sexual assault sexually transmitted infection assessment and/or evaluation initial 30 minutes (Therapeutic or Preventive Procedure)", + "output": "Therapeutic or Preventive Procedure described as assessing and/or evaluating a patient's risk of contracting a sexually transmitted disease(s) following his or her sexual assault. For additional time, use NAAOA. Service is billed in 30-minute increments." + }, + { + "input": "Concept: cotranslational protein modification (Molecular Function)", + "output": "cellular protein modification process described as the process of covalently altering one or more amino acids in a protein after translation has begun but before the protein has been released from the ribosome." + }, + { + "input": "Concept: mean platelet volume (MPV) (Hematology procedure)", + "output": "Hematology procedure described as the determination of the average size of the platelets present in a blood sample." + }, + { + "input": "Concept: MMW Plus HC (Pharmacologic Substance)", + "output": "something described as an oral rinse containing miracle mouthwash and the corticosteroid hydrocortisone, with potential anti-mucositic activity. Upon rinsing with this mouthwash, the ingredients in the miracle mouthwash may provide analgesia; the hydrocortisone modulates the production of pro-inflammatory cytokines which may prevent inflammation of the oral mucosa, and reduce chemotherapy- and/or radiation-induced oral mucositis." + }, + { + "input": "Concept: Absent end part of the toe bones (Abnormality of the epiphyses of the toes)", + "output": "Anatomical Abnormality described as absence of the epiphyses of the phalanges of the toes." + }, + { + "input": "Concept: SOAPR1-Felt Craving for Medication (Intellectual Product)", + "output": "something described as screener and Opioid Assessment for Patients with Pain - Revised - How often have you felt a craving for medication?" + }, + { + "input": "Concept: ADCS-ADL MCI - Description of Usual Performance of Physically Getting Dressed (Intellectual Product)", + "output": "something described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, MCI (ADCS-ADL MCI) Regarding physically getting dressed, which best describes his or her usual performance in the past 4 weeks." + }, + { + "input": "Concept: Tea1 cell-end complex (microtubule associated complex)", + "output": "Cell Component described as a high molecular weight complex characterized in S. pombe containing the cell-end anchoring protein Tea1. This complex is transported to the cell ends by microtubules and is involved in bipolar growth and the maintennce of normal cell polarity." + }, + { + "input": "Concept: PSP test normal (Kidney Function Tests)", + "output": "Finding described as a laboratory test result indicating normal parameters after a phenolsulfonphthaliein test." + }, + { + "input": "Concept: Grade 1 Hematuria, CTCAE (Hematuria, CTCAE)", + "output": "something described as asymptomatic; clinical or diagnostic observations only; intervention not indicated" + }, + { + "input": "Concept: Squared superior portion of helix (Finding)", + "output": "Abnormality of the helix described as flattening instead of curving or rounded superior helix, allowing the superior helix to run more horizontally than usual." + }, + { + "input": "Concept: polysaccharide alpha-L-arabinofuranosidase activity (hydrolase activity, hydrolyzing O-glycosyl compounds)", + "output": "Molecular Function described as catalysis of the hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides." + }, + { + "input": "Concept: Accelerated Approval (Approved)", + "output": "Regulation or Law described as a regulatory process that allows for shortened time to approval of drugs that treat serious conditions and/or fill an unmet medical need based on surrogate or intermediate clinical endpoints." + }, + { + "input": "Concept: Toll-like receptor 2 binding (Molecular Function)", + "output": "Molecular Function described as interacting selectively and non-covalently with a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response." + }, + { + "input": "Concept: oxalate:CoA ligase (Molecular Function)", + "output": "Molecular Function described as catalysis of the reaction: ATP + CoA + oxalate = AMP + diphosphate + H(+) + oxalyl-CoA." + }, + { + "input": "Concept: Flange Device (Device Component or Accessory)", + "output": "Device Component or Accessory described as a protruding edge designed to strengthen or stabilize a device or facilitate its attachment to a surface." + }, + { + "input": "Concept: Percent Recovered from T1 to T2 Normalized by Body Mass Index (Quantitative Concept)", + "output": "Quantitative Concept described as the percentage of the administered dose that is recovered from the specimen type specified in PPSPEC, over the interval between T1 and T2 divided by body mass index." + }, + { + "input": "Concept: cells cycle (cellular process)", + "output": "cellular process described as changes that take place in a cell during the period between its formation as one of the products of cell division and its own subsequent division." + }, + { + "input": "Concept: continent (Clinical or Research Assessment Answer)", + "output": "Clinical or Research Assessment Answer described as a response indicating that an individual is or has been urinary continent for over 7 days." + }, + { + "input": "Concept: KIAA0648 (Gene or Genome)", + "output": "something described as human PDS5A wild-type allele is located in the vicinity of 4p14 and is approximately 155 kb in length. This allele, which encodes sister chromatid cohesion protein PDS5 homolog A protein, is involved in cell division." + }, + { + "input": "Concept: High Resolution Melt Analysis (Laboratory Procedure)", + "output": "DNA analysis described as a reverse, real-time, polymerase chain reaction technique in which fluroescently labeled double-stranded DNA is slowly melted apart by increasing temperature. Genetic mutations and polymorphisms can be detected by analyzing the melt curves, which correspond to the rate at which double-stranded DNA become single-stranded." + }, + { + "input": "Concept: Impaired cortisol response to insulin stimulation test (Abnormal response to insulin tolerance test)", + "output": "Abnormal response to insulin tolerance test described as failure of cortisol levels to respond adequately (by increasing) to the insulin tolerance test (ITT). []" + }, + { + "input": "Concept: Casamassima Morton Nance syndrome (Autosomal recessive hereditary disorder)", + "output": "Urogenital Abnormalities described as syndrome with the association of spondylocostal dysostosis with anal and genitourinary malformations (anal atresia and agenesis of external and internal genitalia). To date, only four cases have been described in the literature." + }, + { + "input": "Concept: Cholesterol Synthesis Inhibition (Physiologic Function)", + "output": "Lipid Metabolism described as cholesterol Synthesis Inhibition involves interference with, or restraint of, the enzymatic formation of the principal sterol of vertebrates in body tissues and blood plasma, an important component of cell membranes, the major precursor for the synthesis of vitamin D and steroid hormones, and an important substance for brain synapses and immune functions." + }, + { + "input": "Concept: Chisels, Surgical, Middle Ear (Chisels, Surgical)", + "output": "Medical Device described as an ear, nose, and throat manual surgical instrument is one of a variety of devices intended for use in surgical procedures to examine or treat the bronchus, esophagus, trachea, larynx, pharynx, nasal and paranasal sinus, or ear. This generic type of device includes the esophageal dilator; tracheal bistour (a long, narrow surgical knife); tracheal dilator; tracheal hook; laryngeal injection set; laryngeal knife; laryngeal saw; laryngeal trocar; laryngectomy tube; adenoid curette; adenotome; metal tongue depressor; mouth gag; oral screw; salpingeal curette; tonsillectome; tonsil guillotine; tonsil screw; tonsil snare; tonsil suction tub; tonsil suturing hook; antom reforator; ethmoid curette; frontal sinus-rasp; nasal curette; nasal rasp; nasal rongeur; nasal saw; nasal scissors; nasal snare; sinus irrigator; sinus trephine; ear curette; ear excavator; ear rasp; ear scissor, ear snare; ear spoon; ear suction tub; malleous ripper; mastoid gauge; microsurgical ear chisel; myringotomy tube inserter; ossici holding clamp; sacculotomy tack inserter; vein press; wire ear loop; microrule; mirror; mobilizer; ear, nose, and throat punch; ear, nose and throat knife; and ear, nose, and throat trocar." + }, + { + "input": "Concept: Medullary Thyroid Carcinoma Pathologic Distant Metastasis TNM Finding v8 (Finding)", + "output": "Medullary Thyroid Carcinoma Pathologic TNM Finding v8 described as a pathologic finding about one or more characteristics of medullary thyroid carcinoma, following the rules of the TNM AJCC v8 classification system as they pertain to distant metastases." + }, + { + "input": "Concept: Broken Bone (Impaired mobility: physiological status)", + "output": "FRACTURES: GENERAL TERMS described as localized disruption of bone or tooth structure resulting in partial or complete discontinuity." + }, + { + "input": "Concept: EOR01-Condition Interfered Family Life (Intellectual Product)", + "output": "something described as european Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire - Core 30 Version 3.0 - During the past week: Has your physical condition or medical treatment interfered with your family life?" + }, + { + "input": "Concept: Leporine ATG/Prednisone/Tacrolimus Regimen (Regimen Used to Treat Myelodysplastic Syndromes)", + "output": "Therapeutic or Preventive Procedure described as a regimen consisting of rabbit anti-thymocyte globulin, prednisone and tacrolimus that can be used in the treatment of myelodysplastic syndrome (MDS) and the prevention and treatment of graft rejection." + }, + { + "input": "Concept: AR Negative (Expression Negative)", + "output": "Laboratory or Test Result described as indicates that expression of AR has not been detected in a sample." + }, + { + "input": "Concept: WD3H1 (Intellectual Product)", + "output": "Intellectual Product described as world Health Organization Disability Assessment Schedule 2.0 - 12-Item Self - Overall, in the past 30 days, how many days were these difficulties present?" + }, + { + "input": "Concept: labile factor (Protein Precursors)", + "output": "Biologically Active Substance described as heat- and storage-labile plasma glycoprotein which accelerates the conversion of prothrombin to thrombin in blood coagulation. Factor V accomplishes this by forming a complex with factor Xa, phospholipid, and calcium (prothrombinase complex). Deficiency of factor V leads to Owren's disease." + }, + { + "input": "Concept: Adult Immunoblastic Large Cell Lymphoma Stage II (Adult Immunoblastic Lymphoma)", + "output": "Adult Immunoblastic Lymphoma described as ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). The number of regions involved may be indicated by a subscript (e.g., II3)." + }, + { + "input": "Concept: Dimethyl Adipinamidate (Organic Chemical)", + "output": "something described as bifunctional cross-linking agent that links covalently free amino groups of proteins or polypeptides, including those in cell membranes. It is used as reagent or fixative in immunohistochemistry and is a proposed antisickling agent." + }, + { + "input": "Concept: Observation Result Relationship Type (Type - attribute)", + "output": "Qualitative Concept described as a particular category of the relationship that defines the meaning and purpose of a clinical study observation result relationship instance." + }, + { + "input": "Concept: Absorption, Pulmonary (Organ or Tissue Function)", + "output": "something described as uptake of substances via the lung." + }, + { + "input": "Concept: CMK (Chemokine Measurement)", + "output": "Laboratory Procedure described as the determination of the amount of CXCL9, chemokine (C-X-C motif) ligand 9, present in a sample." + }, + { + "input": "Concept: intermediate mesoderm morphogenesis (Organ or Tissue Function)", + "output": "Organ or Tissue Function described as the process in which the anatomical structures of the intermediate mesoderm are generated and organized." + }, + { + "input": "Concept: upregulation of immunoglobulin biosynthetic process (positive regulation of immunoglobulin production)", + "output": "something described as any process that activates or increases the frequency, rate, or extent of immunoglobulin biosynthesis." + }, + { + "input": "Concept: Ephrin A4 (Amino Acid, Peptide, or Protein)", + "output": "Ephrins described as a GLYCOINOSITOL PHOSPHOLIPID MEMBRANE ANCHOR containing ephrin found in variety of adult tissue such as KIDNEY; LUNG; COLON and OVARY. During embryonic development, ephrin-A4 is expressed in the HIPPOCAMPUS and CEREBRAL CORTEX. It binds preferentially to ephA receptors (EPH FAMILY RECEPTORS) with the exception of the EPHA1 RECEPTOR." + }, + { + "input": "Concept: Very Good Partial Response (International Myeloma Working Group Standard Response Criteria)", + "output": "International Myeloma Working Group Standard Response Criteria described as serum and urine M-protein detectable by immunofixation but not on electrophoresis or at least 90 percent reduction in serum M-protein plus urine M-protein level less than 100 mg per 24 hours." + }, + { + "input": "Concept: Moderate decrease in food intake (Finding)", + "output": "something described as a response indicating than an individual has or had a moderate decrease in their food intake." + }, + { + "input": "Concept: PR-104 (Pharmacologic Substance)", + "output": "something described as a non-toxic, small-molecule, hypoxia-activated, 3,5-dinitrobenzamide nitrogen mustard pre-prodrug with potential antitumor activity. Upon intravenous administration, PR-104 is converted by systemic phosphatases to the alcohol intermediate PR-104A, which is reduced to form the active DNA-crosslinking mustard species hydroxylamine PR-104H intracellularly under hypoxic conditions. PR-104H specifically crosslinks hypoxic tumor cell DNA, resulting in the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis in susceptible hypoxic tumor cell populations while sparing normoxic tissues. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61590\" active clinical trials using this agent." + }, + { + "input": "Concept: Mitral valve arcade (Anatomical Abnormality)", + "output": "Abnormal mitral valve morphology described as anomalous mitral valve arcade is diagnosed based on the following features (1) An adequately sized mitral valve orifice; (2) short, thick, and poorly differentiated chordae with direct union of the papillary muscles to the anterior leaflet; (3) narrow or nearly nonexistent spaces between the abnormal chordae; and (4) greater differentiation of the chordae attached to the posterior papillary muscle." + }, + { + "input": "Concept: Hodgkin's lymphoma of CNS (Neoplastic Process)", + "output": "Primary central nervous system lymphoma described as a Hodgkin lymphoma that arises from the central nervous system." + }, + { + "input": "Concept: Reactive Lymphocytes/Lymphocytes (Blood Cell Count Ratio Measurement)", + "output": "Blood Cell Count Ratio Measurement described as the determination of the ratio of reactive lymphocytes compared to all lymphocytes present in a sample. The measurement may be expressed as a ratio or percentage." + }, + { + "input": "Concept: IGF-Binding Protein-Related Protein-2 (Growth Factor)", + "output": "Mineral and bone described as cysteine rich mitogen secreted by vascular endothelial cells." + }, + { + "input": "Concept: EED Inhibitor MAK683 (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as an inhibitor of embryonic ectoderm development protein (EED) and allosteric inhibitor of polycomb repressive complex 2 (PRC2), with potential antineoplastic activity. Upon administration, MAK683 selectively binds to the domain of EED that interacts with trimethylated lysine 27 on histone 3 (H3K27me3), which leads to a conformational change in the EED H3K27me3-binding pocket and prevents the interaction of EED with the histone methyltransferase enhancer zeste homolog 2 (EZH2). Disruption of the EED-EZH2 protein-protein interaction (PPI) results in a loss of H3K27me3-stimulated PRC2 activity and prevents H3K27 trimethylation. This decrease in histone methylation alters gene expression patterns associated with cancer pathways and results in decreased tumor cell proliferation in EZH2-mutated and PRC2-dependent cancer cells. PRC2, a histone H3 lysine 27 methyltransferase and multi-protein complex comprised of EZH2, EED and suppressor of zeste 12 (SUZ12), plays a key role in gene regulation, especially during embryonic development. EZH2, the catalytic subunit of PRC2, is overexpressed or mutated in a variety of cancer cells. EED is essential for the histone methyltransferase activity of PRC2 because EED directly binds to H3K27me3. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C133819\" active clinical trials using this agent." + }, + { + "input": "Concept: Transmission, Other/Miscellaneous (disease transmission)", + "output": "Pathologic Function described as passage or transfer, as of a disease, to a recipient individual due to miscellaneous or not otherwise specified circumstances." + }, + { + "input": "Concept: activated CD4-positive, alpha-beta T-cell apoptotic process (T cell apoptotic process)", + "output": "Cell Function described as any apoptotic process in an activated CD4-positive, alpha-beta T cell." + }, + { + "input": "Concept: Theca-lutein cell (Luteal Cells)", + "output": "Luteal Cells described as a cell of the corpus luteum that is derived from the inner layer of the sheath surrounding the graafian follicle." + }, + { + "input": "Concept: Condoms, Unspecified (Contraceptive Agents)", + "output": "Device Labeled for Single Use described as contraceptive device designed to fit over the penis or line the vagina and prohibit the transfer of sperm to the vagina; also used to impede the transfer of sexually communicable diseases." + }, + { + "input": "Concept: CAL (Gene or Genome)", + "output": "Gene or Genome described as this gene plays a role in protein transport." + }, + { + "input": "Concept: indirect (General Qualifier)", + "output": "Qualitative Concept described as not as a direct effect or consequence; having intervening factors or persons or influences." + }, + { + "input": "Concept: DNA primase activity (Genetic Function)", + "output": "something described as catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases." + }, + { + "input": "Concept: paracentric inversion (Cell or Molecular Dysfunction)", + "output": "Cell or Molecular Dysfunction described as a chromosome inversion involving a segment that does not include the centromere." + }, + { + "input": "Concept: Hypertrophic cardiomyopathy and renal tubular disease due to mitochondrial DNA mutation (Mitochondrial Myopathies)", + "output": "Renal tubular acidosis described as a mitochondrial oxidative phosphorylation disorder characterized by hypertrophic and dilated cardiomyopathy, failure to thrive, myopathy with generalized hypotonia and increased creatine kinase, developmental delay and/or regression with cerebral atrophy on brain MRI, renal manifestations including chronic renal failure, renal tubular acidosis and lactic acidosis. Additional clinical features include seizures and respiratory failure." + }, + { + "input": "Concept: Cribriform Pattern (Finding)", + "output": "Morphologic Architectural Pattern described as formation of epithelial pseudoglandular structures with lumens." + }, + { + "input": "Concept: Carbon Tet (Organic Chemical)", + "output": "haloalkane described as CCl4; used as a solvent and starting material in the manufacturing of organic compounds; poisoning by inhalation, ingestion or skin absorption is possible and may be fatal." + }, + { + "input": "Concept: RNA polymerase III transcriptional preinitiation complex assembly (transcription preinitiation complex assembly)", + "output": "Genetic Function described as the aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase III promoter." + }, + { + "input": "Concept: IPA02-Traveling Minutes per Day (Intellectual Product)", + "output": "IPAQ Long Last 7 Days Telephone Format Version Questionnaire Question described as international Physical Activity Questionnaire (November 2002) Long Last 7 Days Telephone Format (IPAQ Long Last 7 Days Telephone Format Version) How much time did you usually spend on one of those days traveling in a car, bus, train or other kind of motor vehicle?: Minutes per day." + }, + { + "input": "Concept: NIH 3T3 Cells (Mouse Cell Line)", + "output": "3T3 Cells described as an immortalized fibroblast cell line derived from a mouse embryo in 1962 by George Todaro and Howard Green. These cells retain contact inhibition." + }, + { + "input": "Concept: naftifin (SKIN AND MUCOUS MEMBRANE ANTIFUNGAL AGENTS)", + "output": "naphthalene described as a topical, synthetic allylamine derivate similar to terbinafine with broad-spectrum antifungal activity. Naftifine can be fungicidal or fungistatic depending on the concentration and the organisms involved." + }, + { + "input": "Concept: Grade 4 Pleural effusion (Pleural Effusion, CTCAE)", + "output": "Finding described as life-threatening respiratory or hemodynamic compromise; intubation or urgent intervention indicated" + }, + { + "input": "Concept: Cardiovascular Organ System (Portuguese translation of the Medical Subject Headings)", + "output": "Finnish translations of the Medical Subject Headings described as organ system which consists of heart, systemic and pulmonary arterial and trees, and lymphatic and portal venous trees and body substance contained within." + }, + { + "input": "Concept: Electric conductivity (Electricity)", + "output": "Physicochemical Property Analysis described as the ability of a substrate to allow the passage of ELECTRONS." + }, + { + "input": "Concept: Membrane Coated Tablet (Film-coated tablet)", + "output": "Film-coated tablet described as a tablet covered with a semipermeable film." + }, + { + "input": "Concept: Deficiency of anterior nasal spine (Anatomical Abnormality)", + "output": "Anatomical Abnormality described as underdevelopment of the anterior nasal spine of maxilla." + }, + { + "input": "Concept: Integrative language functions (Mental functions of language)", + "output": "Mental functions of language described as mental functions that organize semantic and symbolic meaning, grammatical structure and ideas for the production of messages in spoken, written or other forms of language." + }, + { + "input": "Concept: oxytetracycline metabolism (polyketide metabolic process)", + "output": "antibiotic metabolic process described as the chemical reactions and pathways involving oxytetracycline." + }, + { + "input": "Concept: Columbia-Suicide Severity Rating Scale Baseline/Screening Version Phase 1 Study Questionnaire Test Name (Intellectual Product)", + "output": "CDISC Questionnaire Terminology described as columbia-Suicide Severity Rating Scale Baseline/Screening Version Phase 1 Study Version 1/14/2009 test name." + }, + { + "input": "Concept: Incontinence Pad (Medical Device)", + "output": "Absorbent Pads described as absorbent pads used for URINARY INCONTINENCE and usually worn as underpants or pants liners by the ELDERLY." + }, + { + "input": "Concept: positive regulation of symbiont transcription in response to host (positive regulation of nucleobase-containing compound metabolic process)", + "output": "regulation of transcription in response to host described as any process in which an organism activates, maintains or increases the frequency, rate or extent of its transcription as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." + }, + { + "input": "Concept: regulation of translation preinitiation complex assembly (regulation of protein-containing complex assembly)", + "output": "Genetic Function described as any process that modulates the frequency, rate or extent of formation of translation preinitiation complex." + }, + { + "input": "Concept: Abnormal ornithine levels in cerebrospinal fluid (Finding)", + "output": "something described as any deviation from the normal concentration of ornithine in the cerebrospinal fluid." + }, + { + "input": "Concept: Exposure as Collected Sequence Number (Sequence Number)", + "output": "Intellectual Product described as an identifier that describes the relative position of collected exposure data within a series." + }, + { + "input": "Concept: corneal abscess (Corneal Diseases)", + "output": "something described as an abscess of the cornea." + }, + { + "input": "Concept: PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE (Methyltransferase Gene)", + "output": "Methyltransferase Gene described as this gene plays a role in phosphatidylethanolamine metabolism." + }, + { + "input": "Concept: S protein complement component (Blood Proteins)", + "output": "Biologically Active Substance described as fibronectin-like extracellular glycoprotein involved in cell adhesion." + }, + { + "input": "Concept: electronystagmogram (Ophthalmological test)", + "output": "Inner ear operation described as a test to look at voluntary and involuntary eye movements" + }, + { + "input": "Concept: detection of hormone stimulus (detection of chemical stimulus)", + "output": "Cell Function described as the series of events in which a hormone stimulus is received by a cell and converted into a molecular signal." + }, + { + "input": "Concept: Vulvar Syringoma (Benign neoplasm of vulva)", + "output": "something described as a benign neoplasm that arises from eccrine ducts in the vulva and is characterized by the presence of tubules and cysts which are lined by epithelial cells in the densely fibrotic dermis." + }, + { + "input": "Concept: Achromatopsia 1 (Eye)", + "output": "Eye described as a condition where the retina contains no functional cone cells, so that in addition to the absence of color discrimination, vision in lights of normal intensity is difficult." + }, + { + "input": "Concept: Illusory auras (Finding)", + "output": "Finding described as auras with an alteration of actual percepts involving the visual, auditory, somatosensory, olfactory or gustatory systems." + }, + { + "input": "Concept: AQUAPORIN 001 (Biologically Active Substance)", + "output": "Biologically Active Substance described as aquaporin 1 forms a water-specific channel that is constitutively expressed at the PLASMA MEMBRANE of ERYTHROCYTES and KIDNEY TUBULES, PROXIMAL. It provides these cells with a high permeability to WATER. In humans polymorphisms of this protein result in the Colton blood group antigen." + }, + { + "input": "Concept: Metal Carcinogenesis (Research Activity)", + "output": "Research Activity described as the study of the processes by which normal cells are transformed into cancer cells by metals." + }, + { + "input": "Concept: carbohydrate supplement drink (Dietary Supplements)", + "output": "Dietary Supplements described as a nutritional supplement drink containing 12.5% carbohydrates, which may enhance recovery following gastrointestinal (GI) surgery. Oral intake of the carbohydrate drink before surgery may prevent insulin resistance and associated hyperglycemia. It may also maintain adequate protein balance and muscle function. Ultimately, giving carbohydrates immediately before surgery may improve overall recovery time and return of GI function. It may also decrease muscle loss. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C107165\" active clinical trials using this agent." + }, + { + "input": "Concept: Oblique astigmatism (Disease or Syndrome)", + "output": "Astigmatism described as astigmatism in which the refractive power of the vertical meridian is the greatest." + }, + { + "input": "Concept: metanephric podocyte cell fate commitment (Cell Function)", + "output": "something described as the process in which the developmental fate of a cell becomes restricted such that it will develop into a metanephric glomerular visceral epithelial cell. A metanephric glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells in the metanephros." + }, + { + "input": "Concept: care financing health (Quantitative Concept)", + "output": "something described as actual costs of providing services related to the delivery of health care, including the costs of procedures, therapies, and medications; also included are the amounts spent by individuals, groups, nations, or private or public organizations for total health care and/or its various components." + }, + { + "input": "Concept: Monosaccharide Transport Proteins (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as a large group of membrane transport proteins that shuttle MONOSACCHARIDES across CELL MEMBRANES." + }, + { + "input": "Concept: skeletal neoplasm (neoplasm/cancer site)", + "output": "neoplasm/cancer site described as new abnormal skeletal tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease." + }, + { + "input": "Concept: Double outlet right ventricle with subpulmonary ventricular septal defect and pulmonary stenosis (Double Outlet Right Ventricle)", + "output": "Congenital Abnormality described as a double outlet right ventricle with a ventricular spetal defect (a hole between the two bottom chambers (ventricles) of the heart), that is considered to be closely related to the pulmonary origin. There is associated pulmonary stenosis, the abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches." + }, + { + "input": "Concept: killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1 protein, human (Amino Acid, Peptide, or Protein)", + "output": "receptor described as killer cell immunoglobulin-like receptor 2DS1 (304 aa, ~34 kDa) is encoded by the human KIR2DS1 gene. This protein plays a role in natural killer cell-mediated immunity." + }, + { + "input": "Concept: Hamsters, Golden (Hamsters)", + "output": "OTHER DOMESTIC ANIMAL SPECIES described as all Syrian hamsters in captivity are derived from a mother and eight pups that were captured in the wild in Aleppo, Syria by Dr. Israel Aharoni in 1930. Syrian Hamsters exhibit multiple coat colors, gold being the most common, and have a life span of about two to three years. Syrian hamsters are extremely territorial and are prone to attacking other hamsters so cannot be housed together under most circumstances. Females come into estrus every four days and embryo gestation is 16-18 days long. Syrian hamsters may exhibit diarrhea, neoplasms, amyloidosis, polycystic disease, and pregnancy-associated toxemia." + }, + { + "input": "Concept: DMDAT (Date in time)", + "output": "Date in time described as the date on which the subject demographics are taken." + }, + { + "input": "Concept: maintenance of protein localization in T-cell secretory granule (maintenance of protein location in cell)", + "output": "maintenance of protein location in cell described as a process in which a protein is maintained in a secretory granule in a T cell and prevented from moving elsewhere." + }, + { + "input": "Concept: renal tubule (Kidney part)", + "output": "Nephrons described as the anatomical segment of the kidney that is comprised of both the nephron and associated collecting tubules. These tubules or tubes contain fluid that has been filtered through the glomerulus." + }, + { + "input": "Concept: peptide butyryltransferase activity (N-acyltransferase activity)", + "output": "N-acyltransferase activity described as catalysis of the reaction: butyryl-CoA + lysine in peptide = CoA + N-butyryl-lysine-peptide." + }, + { + "input": "Concept: DefinedObservationResult (Result)", + "output": "Result described as a reusable, \"template\" description of a possible outcome of an observation." + }, + { + "input": "Concept: Abdominal aseptic abscess (Abnormality of abdomen morphology)", + "output": "Disease or Syndrome described as an abscess-like lesion located within the abdomen. The lesions are localized in the spleen, liver, abdominal lymph nodes. The lesions represent visceral sterile collections of mature neutrophils that do not respond to antibiotics but regress quickly when treated with corticosteroids, but relapses occur frequently." + }, + { + "input": "Concept: Clonal Regression (Developmental process)", + "output": "something described as a biological process that selectively removes autoantigenic lymphocytes by targeting them for programmed cell death." + }, + { + "input": "Concept: Large Equipment Washers (Washing machines)", + "output": "something described as washers designed for automatic removal of dirt and/or stains (i.e., washing) from large equipment used in hospitals and/or other medical facilities. These washers typically consist of a stainless steel cabinet with front doors (i.e., roll-in/roll-out models) or front-and-back doors that permit pass-through of carts (i.e., tunnel type); a control panel, and appropriate pumps and other accessories needed to perform the washing cycle. Large equipment cleaning washers perform a cycle of operations typically including water prewash, enzyme treatment, detergent washing, and heated rinse; the process may include mechanical removal of contaminants by scrubbing and/or water jets (some devices including mechanical removal of contaminants are considered washer/decontamination units). Some washers include drying capabilities. The washers usually include tall doors to allow washing most large equipment used in healthcare facilities, including wide wheelchairs, commodes, shower and reclining chairs, walkers, and carts." + }, + { + "input": "Concept: Silent Information Regulator Proteins, S cerevisiae (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as a set of nuclear proteins in SACCHAROMYCES CEREVISIAE that are required for the transcriptional repression of the silent mating type loci. They mediate the formation of silenced CHROMATIN and repress both transcription and recombination at other loci as well. They are comprised of 4 non-homologous, interacting proteins, Sir1p, Sir2p, Sir3p, and Sir4p. Sir2p, an NAD-dependent HISTONE DEACETYLASE, is the founding member of the family of SIRTUINS." + }, + { + "input": "Concept: Randomization Quotient (Quantitative Concept)", + "output": "Quotient described as the number of planned subjects to be exposed to investigational therapy, independent of dose or other factors, divided by the total number of planned subjects." + }, + { + "input": "Concept: Portable Urinals, Male (Manufactured Object)", + "output": "Urinals, Portable described as portable urinals designed for male use. These urinals typically are containers with appropriate openings according to male anatomy and are intended for direct urination. These urinals typically consist of handheld portable containers made of plastic (for single-patient use) or made of glass or metal (reusable). Some urinals include attached lids and/or other devices to prevent spills and they may or may not be attached to a tube for drainage of urine to a collection bag, leaving the urinal empty and ready for the next use. Male personal urinals are mainly used by bedridden patients, patients using wheelchairs, and people with other disabilities or incontinence." + }, + { + "input": "Concept: very low density lipoprotein (VLDL) level test (Lipids measurement)", + "output": "something described as the determination of the amount of very low-density lipoprotein cholesterol present in a sample." + }, + { + "input": "Concept: Visilizumab (Pharmacologic Substance)", + "output": "Monoclonal Antibodies described as a monoclonal antibody that binds to CD3 (a substance found on T-cells) and that is being studied as a treatment for graft-versus-host disease (GVHD). It belongs to the family of drugs called monoclonal antibodies." + }, + { + "input": "Concept: urachus (Urinary Bladder)", + "output": "Umbilical cord structure described as a cord of fibrous tissue that extends from the urinary bladder to the umbilicus; the urachus is a remnant of the fetal urinary canal." + }, + { + "input": "Concept: Anti-B7-H3 CAR T-cells (Antineoplastic Immune Cell)", + "output": "Cell described as a preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) and containing, as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, anti-B7-H3 CAR T-cells target and bind to B7-H3-expressing tumor cells, thereby inducing selective toxicity in B7-H3-expressing tumor cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It is a negative regulator of the T-cell activation and its overexpression plays a key role in tumor cell invasion and metastasis." + }, + { + "input": "Concept: Neck Lymph Node Boundary Sublevel IA (Neck Lymph Node Boundary Levels and Sublevels)", + "output": "Neck Lymph Node Boundary Levels and Sublevels described as the following anatomical structures define the neck lymph node boundary for sublevel IA: Superior: symphysis of the mandible; inferior: body of the hyoid; anterior (medial): anterior belly of the contralateral digastric muscle; posterior (lateral): anterior belly of the ipsilateral digastric muscle." + }, + { + "input": "Concept: Blasts 11-20 Percent of Bone Marrow Nucleated Cells (Laboratory or Test Result)", + "output": "something described as a semi-quantitative microscopic finding indicating that between 11 and 20 percent of the nucleated cells in a bone marrow sample are immature mononuclear cells." + }, + { + "input": "Concept: 2-carboxy-2-hydroxy-8-carboxychromene isomerase activity (intramolecular oxidoreductase activity)", + "output": "intramolecular oxidoreductase activity described as catalysis of the reaction: 2-carboxy-2-hydroxy-8-carboxychromene = 2-hydroxy-3-carboxybenzalpyruvate." + }, + { + "input": "Concept: Neoplasm of sebaceous gland (Skin Neoplasms)", + "output": "Sebaceous Gland Diseases described as new abnormal growth of tissue in the SEBACEOUS GLANDS." + }, + { + "input": "Concept: EKG ST ELEVATION (EKG ST segment changes)", + "output": "Coronary Artery Disease described as an electrocardiographic finding of ST segment elevation above the baseline." + }, + { + "input": "Concept: MAGFSTR (Medical Device Attribute)", + "output": "something described as a measurement of the force of magnetism that acts in the region around a magnetic material or a moving electrical charge." + }, + { + "input": "Concept: Lexibulin (Pharmacologic Substance)", + "output": "Tubulin Binding Agent described as an orally bioavailable small-molecule with tubulin-inhibiting, vascular-disrupting, and potential antineoplastic activities. Lexibulin inhibits tubulin polymerization in tumor blood vessel endothelial cells and tumor cells, blocking the formation of the mitotic spindle and leading to cell cycle arrest at the G2/M phase; this may result in disruption of the tumor vasculature and tumor blood flow, and tumor cell death. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C77882\" active clinical trials using this agent." + }, + { + "input": "Concept: Oral Mechanism/Cranial Nerve Examination for Young Children (Intellectual Product)", + "output": "something described as a clinical protocol developed for the purpose of assessing the oral and speech motor abilities of children. The protocol can be administered in 7-10 minutes, and a child's performance can be compared to developmental norms." + }, + { + "input": "Concept: N1 Hydroxy N8 phenyloctanediamide (Medicinal product categorized by structure)", + "output": "Chemical categorised functionally described as a hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME." + }, + { + "input": "Concept: Microsatellite Instability Present (gene mutation-related cancer)", + "output": "Cell or Molecular Dysfunction described as the occurrence of highly polymorphic mono- and dinucleotide MICROSATELLITE REPEATS in somatic cells. It is a form of genome instability associated with defects in DNA MISMATCH REPAIR." + }, + { + "input": "Concept: Diameter (Quantitative Concept)", + "output": "Property or Attribute described as the length of a straight line passing through the center of a circle or sphere and connecting two points on the circumference." + }, + { + "input": "Concept: Hemolytic Anemia Gene Panel Reagents (Medical Device)", + "output": "IVD Panels, Human Genetics, Blood Disorder described as molecular assay reagents intended to identify gene variants associated with hemolytic anemia, a collection of conditions in which red blood cell destruction outpaces their production. Genetic variants at multiple loci have been associated with hemolytic anemia. These reagents are intended to detect various types of genetic changes (e.g., deletions, duplications, insertions, single nucleotide polymorphisms) in multiple hemolytic anemia-associated loci simultaneously." + }, + { + "input": "Concept: peptidyl-glutamine 2-methylation (peptidyl-glutamine methylation)", + "output": "something described as the methylation of glutamine to form 2-methyl-L-glutamine." + }, + { + "input": "Concept: Stage IIIB Vulvar Cancer (Neoplastic Process)", + "output": "Neoplastic Process described as stage IIIB includes: (T1/T2, N2a/N2b, M0). T1: Invasive vulvar cancer confined to the vulva or perineum. T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement). N2a: Vulvar cancer with three or more lymph node metastases each measuring 5 mm or less. N2b: Vulvar cancer with two or more lymph node metastases measuring 5 mm or greater. M0: No distant metastasis." + }, + { + "input": "Concept: Motor impersistence (Abnormality of coordination)", + "output": "Abnormality of coordination described as the inability to maintain postures or positions (such as keeping eyes closed, protruding the tongue, maintaining conjugate gaze steadily in a fixed direction, or making a prolonged 'ah' sound) without repeated prompts." + }, + { + "input": "Concept: Sticks, Walking (Technical Aids for the Disabled)", + "output": "Technical Aids for the Disabled described as a cane is a device intended for medical purposes that is used to provide minimal weight support while walking. Examples of canes include the following: A standard cane, a forearm cane, and a cane with a tripod, quad, or retractable stud on the ground end." + }, + { + "input": "Concept: Scaphoid-Lunate Joint (Wrist joint)", + "output": "Body Space or Junction described as the articulation of the scaphoid and lunate bones in the wrist." + }, + { + "input": "Concept: Dental Care for Elderly (Health Care Activity)", + "output": "Health Care Activity described as the giving of attention to the special dental needs of the elderly for proper maintenance or treatment. The dental care may include the services provided by dental specialists." + }, + { + "input": "Concept: DNA methylation involved in embryo development (DNA Methylation)", + "output": "Genetic Function described as the covalent transfer of a methyl group to C-5 of cytosine that contributes to the epigenetic regulation of embryonic gene expression." + }, + { + "input": "Concept: Breast Columnar Cell Mucinous Carcinoma (Mucinous Adenocarcinoma)", + "output": "Neoplastic Process described as an invasive breast adenocarcinoma characterized by the presence of tall columnar neoplastic cells that contain intracytoplasmic mucin. Grossly, cystic changes are not identified." + }, + { + "input": "Concept: Bone development (Musculoskeletal Development)", + "output": "Musculoskeletal Development described as the process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components." + }, + { + "input": "Concept: Terminating vocational training program (Vocational Training)", + "output": "Vocational Training described as leaving vocational training programme in an appropriate manner to enter the next level of school education, work, employment or other domains of adult life." + }, + { + "input": "Concept: Basal Cell Carcinoma of Scrotum (Scrotal Carcinoma)", + "output": "something described as a basal cell carcinoma that arises from the scrotum." + }, + { + "input": "Concept: Powder for Sealant Dosage Form (Biomedical or Dental Material)", + "output": "Powder dose form described as solid sterile preparation consisting of one or more powders, including freeze-dried powders, intended to be dissolved in the specified liquid to obtain a sealant. Comment: Please note that this term is not equivalent to the term 'Sealant powder'." + }, + { + "input": "Concept: Centrifuges, Tabletop, Low-Speed, Nonrefrigerated, Blood Bank (Centrifuges, Tabletop, Low-Speed, Nonrefrigerated)", + "output": "Medical Device described as nonrefrigerated low-speed tabletop centrifuges used to centrifuge solutions of suspended red blood cells, enhancing agglutination and promoting the formation of packed cells at the bottom of the tube that remains during the decantation step of manual cell washing. Most blood bank centrifuges have a timer connected to the motor that allows timed use, and mechanical or electric brakes; refrigeration is an available option in some models." + }, + { + "input": "Concept: BTL/ETV6 Fusion Gene (Gene or Genome)", + "output": "Fusion Gene described as a fusion gene that results from a chromosomal translocation t(4;12)(q11-q21;p13) which fuses exons 1-3 of the CHIC2 gene to exons 2-8 of the ETV6 gene. This fusion may be associated with acute myeloid leukemia." + }, + { + "input": "Concept: left anterior flagellum (Cell Component)", + "output": "something described as a cilium (also called flagellum) found in Giardia species (trophozoite stage). It originates at the left anterior basal body, extends laterally through the cytoplasm, crosses the right anterior axoneme, and exits as a membrane-bound flagellum on the anterior left side of the cell." + }, + { + "input": "Concept: Nitroferricyanide (Vasodilator [EPC])", + "output": "Cyanides described as powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function, also used as an indicator for free sulfhydryl groups in proteins." + }, + { + "input": "Concept: Index, Erythrocyte (Red blood cell test)", + "output": "Blood Indices described as ERYTHROCYTE size and HEMOGLOBIN content or concentration, usually derived from ERYTHROCYTE COUNT; BLOOD hemoglobin concentration; and HEMATOCRIT. The indices include the mean corpuscular volume (MCV), the mean corpuscular hemoglobin (MCH), and the mean corpuscular hemoglobin concentration (MCHC)." + }, + { + "input": "Concept: Minute Times Picomole Per Liter Per Kilogram (Measurement Unit Description)", + "output": "Quantitative Concept described as minutes times picomoles per liter (area under the curve), divided by kilograms (weight)." + }, + { + "input": "Concept: cellular response to adenine starvation (Cell Function)", + "output": "cellular response to starvation described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of adenine." + }, + { + "input": "Concept: 2-hydroxy-3-keto-5-methylthio-phosphopentene phosphatase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the reaction: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate is also known as HK-MTPenyl-P, and 1,2-dihydroxy-3-keto-5-methylthiopentene as DHK-MTPene." + }, + { + "input": "Concept: Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes (Molecular Function)", + "output": "Regulatory Pathway described as the eukaryotic genome is packaged by histone and nonhistone proteins to form chromatin. The assembly of nucleosomes, as well as compaction of nucleosomal arrays into higher-order chromatin structures, creates a highly restrictive environment for nuclear processes that require access to DNA. The packaging of eukaryotic DNA into nucleosomes inhibits the access of factors to DNA and thus results in the repression of transcription, replication, and recombination. To counterbalance the repressive nature of chromatin, a variety of chromatin remodeling factors use the energy of ATP hydrolysis to facilitate the interaction of proteins with nucleosomal DNA. ATP dependent chromatin remodeling complexes are characterized by the presence of an ATPase subunit from the SNF2-like family of the DEAD/H (SF2) DNA-stimulated ATPases. The highly conservative hSWI/SNF multisubunit complexes contain hBRM or BRG1 ATPases which alter the histone-DNA contacts enabling the access of general transcription factors to promoter regions. Remodeling complexes are targeted to promoters via interactions with sequence-specific transcription factors. Since chromatin constitutes a barrier for processes affecting DNA, such a transcription, replication, and repair, a mechanism is required that can open up or remodel chromatin to make it accessible to replication and transcription factors. Steroid receptors are a class of transcription factors that can interact with the repressive chromatin structure and remodel the chromatin to allow other transcription factors to bind. In addition to nuclear receptors, transcription activators as divergent as erythroid Kruppel-like factor, C/EBPs, c-Myc, MyoD, HSF1, and EBNA2 have also been found to recruit SWI/SNF to specific promoters. The role of steroid receptors in chromatin remodeling and transcription is exemplified by the glucocorticoid receptor (GR)-mediated transactivation of the mouse mammary tumor virus (MMTV) promoter. The MMTV promoter is organized into a phased array of six nucleosomes when stably integrated into mammalian cells. The second nucleosome (nucB) is positioned over the binding sites for the GR and nuclear factor 1 (NF1). Binding of NF1 is essential for GR-mediated transactivation of the MMTV promoter; in the absence of glucocorticoid, the chromatin structure of the promoter excludes the binding of NF1. Upon hormone administration, GR recruits an ATP-dependent remodeling hSWI/SNF complex (BRG1-BAF) to remodel the chromatin Individually, the GR makes direct interactions with BRG1-associated factor 60a (BAF60a) and BAF57. Further, BAF60a possesses at least two interaction surfaces, one for GR and BRG1 and a second for BAF155 and BAF170.The remodeling process converts the closed conformation of the MMTV promoter to an open one without altering the nucleosomal positioning. The remodeling of the promoter permits NF1 binding and the assembly of a transcription initiation complex." + }, + { + "input": "Concept: peptidyl-glycyl-phosphatidylethanolamine formation from peptidyl-glycine (Molecular Function)", + "output": "something described as the chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked phosphatide following hydrolysis of a glycyl-peptide bond, as in the cleavage of arginine from the carboxy-terminal of Apg8 followed by its amidation with phosphatidylethanolamine." + }, + { + "input": "Concept: Asterococcus arthritidis (Mycoplasma)", + "output": "Mycoplasma described as a species of gram-negative bacteria causing purulent POLYARTHRITIS in RATS." + }, + { + "input": "Concept: Dickkopf WNT Signaling Pathway Inhibitor 1 (Laboratory Procedure)", + "output": "Protein or Enzyme Type Measurement described as the determination of the amount of dickkopf WNT signaling pathway inhibitor 1 present in a sample." + }, + { + "input": "Concept: QS-IPAQ Long Last 7 Days Telephone Format Version TESTCD (CDISC Questionnaire Terminology)", + "output": "CDISC Questionnaire Terminology described as test codes of questionnaire questions associated with the International Physical Activity Questionnaire (November 2002) Long Last 7 Days Telephone Format (IPAQ Long Last 7 Days Telephone Format Version) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: Interphalangeal Joint 1 of the Foot (Body Part, Organ, or Organ Component)", + "output": "Interphalangeal joint of toe described as a ginglymoid (hinge) synovial joint within the first digit of the foot articulating the proximal and distal phalanges." + }, + { + "input": "Concept: Bennett fracture (Fracture of upper limb)", + "output": "Eponymic Fractures and Dislocations described as fracture and dislocation of the first metacarpal and the carpal-metacarpal joint" + }, + { + "input": "Concept: protein amino acid polyamination (cellular protein modification process)", + "output": "cellular protein modification process described as the modification of a protein amino acid by polyamination." + }, + { + "input": "Concept: Fuzzy Logic (Theoretical model)", + "output": "something described as a mathematical technique used to deal with imprecise data and problems." + }, + { + "input": "Concept: Stem Cells, Pluripotent (Stem cells)", + "output": "something described as cells with an unlimited capacity to divide and the ability to turn into most of the cells or tissues in the body; derived from inner cell mass cells from blastocyst stage embryos, primordial germ cells from fetal tissue, and possibly by somatic cell nuclear transfer; do not have the potential to form an individual organism because they do not have the capacity to give rise to the cells of the placenta or other extraembryonic tissues necessary for implantation, nor can they support fetal development in the uterus; useful application as a renewable source of replacement cells and tissue to treat a myriad of diseases, conditions and disabilities, i.e. stem cell therapy." + }, + { + "input": "Concept: anomaly; tricuspid (valve), Ebstein (Congenital cardiac structural defects NEC)", + "output": "Congenital cardiac structural defects NEC described as a congenital heart defect characterized by downward or apical displacement of the TRICUSPID VALVE, usually with the septal and posterior leaflets being attached to the wall of the RIGHT VENTRICLE. It is characterized by a huge RIGHT ATRIUM and a small and less effective right ventricle." + }, + { + "input": "Concept: Peak Response Amplitude Latency (Elapsed Time)", + "output": "Elapsed Time described as a measurement of the time interval between a stimulus and the maximal response." + }, + { + "input": "Concept: Autologous HBV Antigen-specific TCR-redirected T-Cells (therapeutic autologous lymphocytes)", + "output": "T-cell Receptor-engineered T-cells described as a preparation of human autologous T-lymphocytes transduced with a viral vector encoding for a T-cell receptor (TCR) specific for a human hepatitis B virus (HBV) surface antigen (HBsAg), with potential antineoplastic activity. Following administration, the autologous HBV antigen specific TCR-redirected autologous T-lymphocytes recognize and bind to the HBV antigen-positive cells, which induces cytotoxic T-lymphocyte (CTL)-mediated elimination of HBV antigen-positive cancer cells. HBV antigens are found on HBV-positive cells and HPV-induced hepatocellular carcinoma (HCC)." + }, + { + "input": "Concept: Gene Modification (Molecular Biology Research Technique)", + "output": "Molecular Genetic Technique described as genetic engineering or molecular biology techniques that involve DNA REPAIR mechanisms for incorporating site-specific modifications into a cell's genome." + }, + { + "input": "Concept: alpha-D-mannoside mannohydrolase activity (mannosidase activity)", + "output": "Molecular Function described as catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides." + }, + { + "input": "Concept: PQL15TC (CDISC Questionnaire Terminology)", + "output": "Intellectual Product described as test codes of questionnaire questions associated with the Pediatric Quality of Life Neuromuscular Module Acute Version 3.0 Parent Report for Child (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Child) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: Zygote Intrafallopian Transfers (Operation on fallopian tube)", + "output": "Fertilization in Vitro described as a technique in assisted reproduction (REPRODUCTIVE TECHNIQUES, ASSISTED) consisting of hormonal stimulation of the ovaries, follicular aspiration of preovulatory oocytes, in-vitro fertilization, and intrafallopian transfer of zygotes at the pronuclear stage (before cleavage)." + }, + { + "input": "Concept: Readiness for enhanced communication (Finding related to ability to communicate)", + "output": "Readiness finding described as a pattern of exchanging information and ideas with others, which can be strengthened." + }, + { + "input": "Concept: peptidyl-phenylalanine modification (peptidyl-amino acid modification)", + "output": "peptidyl-amino acid modification described as the modification of peptidyl-phenylalanine." + }, + { + "input": "Concept: lateral attachment of mitotic spindle microtubules to kinetochore (attachment of mitotic spindle microtubules to kinetochore)", + "output": "attachment of mitotic spindle microtubules to kinetochore described as the cell cycle process in which sister chromatids become laterally attached to spindle microtubules as part of mitotic metaphase plate congression. Attachment precedes migration along microtubules towards the spindle equator (metaphase plate)." + }, + { + "input": "Concept: health occupations (MeSH Spanish)", + "output": "prevention and health care described as professions or other business activities directed to the cure and prevention of disease. For occupations of medical personnel who are not physicians but who are working in the fields of medical technology, physical therapy, etc., ALLIED HEALTH OCCUPATIONS is available." + }, + { + "input": "Concept: GAIA Level 2b Failure to Thrive (Intellectual Product)", + "output": "GAIA Failure to Thrive Level of Diagnostic Certainty described as GAIA Level 2b Failure to Thrive is defined by either of two criteria: first, the following four requirements must be present: a) Infant age determined by a documented birth date; b) Weights are obtained using a spring balance scale; c) A minimum of two weights measured at least four weeks apart; d) Weight for age deceleration must pass through at least two centile spaces on a growth chart; OR second, the following three requirements must be present: a) Weight is measured using an electronic scale or beam balance scale; b) Length is documented using infantometer; c) Weight for length ratio less than or equal to the third centile on an appropriate growth chart." + }, + { + "input": "Concept: Zamiaceae Horan., 1837 (Gymnosperm)", + "output": "Plants described as a plant family of the order Cycadales, class Cycadopsida, division CYCADOPHYTA." + }, + { + "input": "Concept: Positive Transfer (Psychological Transfer)", + "output": "Psychological Transfer described as previous learning or practice which aids the acquisition of new material or skills as the result of common characteristics shared by the prior and current learning situation." + }, + { + "input": "Concept: Glioma Associated Oncogene Family Zinc Finger 3 Protein (Repressor Proteins)", + "output": "Kruppel-Like Transcription Factors described as a zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES." + }, + { + "input": "Concept: Test Article Physical Substance Classification (Classification)", + "output": "Classification described as the general substance class of the test article, based on physical, biochemical, and/or other composition of matter properties." + }, + { + "input": "Concept: negative regulation of enamel mineralization (regulation of enamel mineralization)", + "output": "negative regulation of tooth mineralization described as any process that stops, prevents, or reduces the frequency, rate or extent of enamel mineralization, the deposition of calcium salts in tooth enamel." + }, + { + "input": "Concept: Autosomal recessive palmoplantar keratoderma and congenital alopecia Wallis type (Hereditary palmoplantar keratoderma)", + "output": "alopecia congenita described as a rare genetic skin disorder with characteristics of congenital alopecia and palmoplantar hyperkeratosis. It is usually associated with cataracts, progressive sclerodactyly and pseudo-ainhum. To date the syndrome has been reported in two families (seven affected individuals) plus an additional sporadic patient was likely affected by the same condition. Usually presents during infancy with manifestations of fading of facial, scalp and body hair within the first months of life without subsequent re-growth. Body and facial keratosis pilaris are additional features that appear in the following years. Skin thickening of palms and soles develops during infancy and may have an unusual pattern affecting the two sides of fingers and palms, but usually sparing the palmar surfaces." + }, + { + "input": "Concept: Congenital hypoplasia of ovary (Congenital Abnormality)", + "output": "Congenital Abnormality described as developmental hypoplasia of the ovary." + }, + { + "input": "Concept: Ancient Greece (Geographic Area)", + "output": "something described as a civilization extant from about 1200 BC. to the death of Alexander the Great, in 323 B.C. It extended from the Greek city states to North Africa and eastward to the Indus River." + }, + { + "input": "Concept: brachial plexus (Brachial plexus structure)", + "output": "Somatic nerve plexus structure described as a nerve network originating from C5 to T1 that supplies cutaneous and muscular innervation to the arm and hand." + }, + { + "input": "Concept: osteoblast differentiation (Cell Function)", + "output": "Cell Function described as the process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone." + }, + { + "input": "Concept: Stage I Cervical Carcinoma FIGO 2018 (Cervical Cancer by FIGO Stage 2018)", + "output": "Neoplastic Process described as the carcinoma is strictly confined to the cervix (extension to the uterine corpus should be disregarded)." + }, + { + "input": "Concept: PDE4 Phosphodiesterases (3',5'-Cyclic-Nucleotide Phosphodiesterase)", + "output": "Amino Acid, Peptide, or Protein described as a cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL-MEDIATED IMMUNITY. The enzyme family includes over twenty different variants that occur due to multiple ALTERNATIVE SPLICING of the mRNA of at least four different genes." + }, + { + "input": "Concept: STAT5B-RARA Fusion Gene (Gene or Genome)", + "output": "Fusion Gene described as a fusion gene that results from a complex rearrangement of 17q21 that fuses the 5' portion of the STAT5B gene to exon 3 of the RARA gene. This chromosomal aberration may be associated with acute promyelocytic leukemia." + }, + { + "input": "Concept: SECTIONS 7-8-9 GENITOURINARY SYSTEM (Anatomy)", + "output": "French translation of the Medical Subject Headings described as all the organs involved in reproduction and the formation and release of URINE. It includes the kidneys, ureters, BLADDER; URETHRA, and the organs of reproduction - ovaries, UTERUS; FALLOPIAN TUBES; VAGINA; and CLITORIS in women and the testes; SEMINAL VESICLES; PROSTATE; seminal ducts; and PENIS in men." + }, + { + "input": "Concept: positive regulation of secondary cell septum biogenesis (regulation of secondary cell septum biogenesis)", + "output": "something described as any process that activates or increases the frequency, rate or extent of secondary cell septum biogenesis." + }, + { + "input": "Concept: Aplasia/Hypoplasia of the gallbladder (Abnormal gallbladder morphology)", + "output": "something described as absence or underdevelopment of the gallbladder." + }, + { + "input": "Concept: Procambarus (Cambarinae)", + "output": "Eukaryote described as genus in the family Cambaridae." + }, + { + "input": "Concept: myosin II tail binding (myosin tail binding)", + "output": "Molecular Function described as interacting selectively and non-covalently with the tail region of a myosin II heavy chain." + }, + { + "input": "Concept: Sternothyroid Muscle (Muscle)", + "output": "Structure of infrahyoid muscle described as a skeletal muscle belonging to the infrahyoid muscle group, located in the anterior part of the neck, with its origin on the sternum and its insertion on the thyroid cartilage; it functions to depress the hyoid bone and larynx during swallowing and speaking." + }, + { + "input": "Concept: RSONGO (Event Occurrence Indicator)", + "output": "Finding described as an indication or description that assessment of disease response or clinical classification of the disease is continuing." + }, + { + "input": "Concept: Crithidia fasciculatas (Eukaryote)", + "output": "Eukaryote described as a species of monogenetic, parasitic protozoa usually found in insects." + }, + { + "input": "Concept: Cross-sectional Thickness, End Ventricular Systole (Finding)", + "output": "something described as the cross-sectional thickness of a tissue measured at end ventricular systole." + }, + { + "input": "Concept: EC 6.3.4.5 (Ligase)", + "output": "Enzyme described as argininosuccinate synthase (412 aa, ~47 kDa) is encoded by the human ASS1 gene. This protein is involved in the biosynthesis of arginine." + }, + { + "input": "Concept: Planned Challenge Agent Exposure Units (Quantitative Concept)", + "output": "something described as the unit of measure for the planned challenge agent exposure." + }, + { + "input": "Concept: Community Disaster Preparedness (Prophylactic treatment)", + "output": "Therapeutic or Preventive Procedure described as providing community's members with education and/or information regarding large scale disasters to prepare their community to respond effectively to a large scale disaster." + }, + { + "input": "Concept: Supraglottic Carcinoma pT4b TNM Finding v8 (Finding)", + "output": "Supraglottic Cancer pT4 TNM Finding v8 described as supraglottic cancer with very advanced local disease. Tumor invades prevertebral space, encases carotid artery, or invades mediastinal structures." + }, + { + "input": "Concept: PQL10-Hard to Use Bathroom (PedsQL Neuromuscular Module Acute Version 3.0 Young Adult Report Questionnaire Question)", + "output": "something described as pediatric Quality of Life Neuromuscular Module Acute Version 3 Young Adult - In the past 7 days, how much of a problem has this been for you: It is hard to use the bathroom." + }, + { + "input": "Concept: Proctosigmoidectomy (Partial resection of colon)", + "output": "Colon and Rectal Surgery described as surgical removal part or all of the sigmoid colon, and part or all of the rectum." + }, + { + "input": "Concept: Population of all large unstained cells in portion of fluid (Population of cells in portion of fluid)", + "output": "Population of cells in portion of fluid described as large unstained cells is reported by laboratories when large peroxidase-negative cells cannot be characterised further as large lymphocytes, virocytes, or stem cells." + }, + { + "input": "Concept: Infant Vascular Clamps, Microsurgical (Medical Device)", + "output": "Medical Device described as vascular surgical clamps designed for the atraumatic compression of veins or arteries during microsurgical vascular procedures in infants/neonates, usually to cause total or partial occlusion (i.e., coarctation). These clamps are typically handheld, manual instruments including two parts pivoted at the center; dedicated microclamps of appropriate sizes and configurations are available for performing specific surgical procedures on infants." + }, + { + "input": "Concept: Genome-Wide 5-Hydroxymethylcytosine Analysis (Laboratory Procedure)", + "output": "something described as the characterization and quantitation of sites within DNA sequences that contain 5-hydroxymethylcytosine modifications across the entire genome of biological sample or specimen." + }, + { + "input": "Concept: EPIC201 (EPIC-CP Questionnaire Question)", + "output": "Intellectual Product described as expanded Prostate Cancer Index Composite for Clinical Practice - Overall, how much of a problem has your urinary function been for you?" + }, + { + "input": "Concept: SALIVA (Digestive system fluid)", + "output": "Portion of body fluid solution described as the clear, viscous fluid secreted by the SALIVARY GLANDS and mucous glands of the mouth. It contains MUCINS, water, organic salts, and ptylin." + }, + { + "input": "Concept: Indolizidines (Organic Chemical)", + "output": "something described as saturated indolizines that are fused six and five-membered rings with a nitrogen atom at the ring fusion. They are biosynthesized in PLANTS by cyclization of a LYSINE coupled to ACETYL COENZYME A. Many of them are naturally occurring ALKALOIDS." + }, + { + "input": "Concept: Peripheral Nervous System Neoplasm (Neoplastic Process)", + "output": "Neuropathy described as a benign or malignant neoplasm arising from a peripheral nerve or the perineural sheaths. -- 2003 Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C3321\" active clinical trials using this agent." + }, + { + "input": "Concept: Past Seven Days Frequency of Unexpected or Excessive Sweating During the Day or Nighttime (Clinical or Research Assessment Question)", + "output": "Clinical or Research Assessment Question described as a question about the frequency of an individual's unexpected or excessive daytime or nighttime sweating over the past seven days." + }, + { + "input": "Concept: Stage 0is Squamous Cell Carcinoma of the Penis AJCC v8 (Stage 0 Penile Cancer AJCC v8)", + "output": "Stage 0 Penile Cancer AJCC v8 described as stage 0is includes: Tis, N0, M0. Tis: Penile cancer with a finding of carcinoma in situ (penile intraepithelial neoplasia [PeIN]). N0: No lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C140077\" active clinical trials using this agent." + }, + { + "input": "Concept: caudal part of the lateral septal nucleus (Body Part, Organ, or Organ Component)", + "output": "something described as one of three divisions of the lateral septal nucleus in the rat ( Swanson-2004 ) and the mouse ( Dong-2004 ). The other two are the rostral part of the lateral septal nucleus and the ventral part of the lateral septal nucleus. The caudal part consists of a dorsal and a ventral zone each of which has several regions." + }, + { + "input": "Concept: Thresholds, Auditory (Threshold)", + "output": "Threshold described as lowest sound intensity or pitch a subject can detect or that can elicit a response." + }, + { + "input": "Concept: Investigator Confidentiality Agreement (Clinical Trial Agreement)", + "output": "Clinical Trial Agreement described as a legally binding arrangement between the sponsor and an outside party (Investigator or Institution) that defines the terms and basic criteria to assure that the party or parties receiving confidential information will maintain confidentiality and will not use that information for any purpose other than that described in the Agreement. May also be present in the Clinical Trial Agreement." + }, + { + "input": "Concept: ANTIGENS, HA (INCLUDING HA CONTROL), PARAINFLUENZA VIRUS 1-4 (Indicator, Reagent, or Diagnostic Aid)", + "output": "Indicator, Reagent, or Diagnostic Aid described as parainfluenza virus serological reagents are devices that consist of antigens and antisera used in serological tests to identify antibodies to parainfluenza virus in serum. The identification aids in the diagnosis of parainfluenza virus infections and provides epidemiological information on diseases caused by these viruses. Parainfluenza viruses cause a variety of respiratory illnesses ranging from the common cold to pneumonia." + }, + { + "input": "Concept: Phosphate to Creatinine Ratio Measurement (Laboratory Procedure)", + "output": "Laboratory Procedure described as the determination of the ratio of phosphate compared to creatinine present in a sample. The measurement may be expressed as a ratio or percentage." + }, + { + "input": "Concept: Transmission, Occupationally Related (Pathologic Function)", + "output": "disease transmission described as passage or transfer, as of a disease, to a recipient individual within or due to occupational circumstances." + }, + { + "input": "Concept: Color Constancy (Mental Process)", + "output": "Perceptual Constancy described as the tendency to perceive hue, brightness, and saturation as stable despite objective changes in context and illumination." + }, + { + "input": "Concept: IWG Cheson MDS 2006 Oncology Response Criteria (Tumor Response Criterion)", + "output": "Tumor Response Criterion described as clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia. (Cheson BD, Greenberg PL, Bennett JM, Lowenberg B, Wijermans PW, Nimer SD, Pinto A, Beran M, de Witte TM, Stone RM, Mittelman M, Sanz GF, Gore SD, Schiffer CA, Kantarjian H. Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia. Blood. 2006 Jul 15;108(2):419-25. Epub 2006 Apr 11.)" + }, + { + "input": "Concept: Axitinib Regimen (Chemo(immuno)therapy Regimen Used to Treat Thyroid Cancer)", + "output": "Chemo(immuno)therapy Regimen Used to Treat Thyroid Cancer described as a chemotherapy regimen consisting of axitinib that may be used in the treatment of follicular, papillary and Hurthle cell thyroid carcinomas, and kidney cancer." + }, + { + "input": "Concept: glutamate breakdown via 2-oxoglutarate (2-oxoglutarate metabolic process)", + "output": "Molecular Function described as the chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxoglutarate." + }, + { + "input": "Concept: Pro-Opiocortin (Adrenocorticotrophic hormone precursor)", + "output": "Prohormone described as a 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP)." + }, + { + "input": "Concept: Conus medullaris (Lumbosacral spinal cord)", + "output": "CAUDA EQUINA AND FILUM described as the terminal, cone-shaped end of the spinal cord." + }, + { + "input": "Concept: RasGAP-Fyn-Lyn-Yes complex location (Cell Component)", + "output": "Cell Component described as a protein complex that consists of a GTPase activator protein (GAP) for Ras and three Src family protein tyrosine kinases, Fyn, Lyn and Yes. The complex is involved in signaling upon platelet activation." + }, + { + "input": "Concept: Anabaena variabilis (Bacterium)", + "output": "Bacterium described as a species of ANABAENA that can form SPORES called akinetes." + }, + { + "input": "Concept: Abnormality of the calvarium sutures (Abnormality of the fontanelles or cranial sutures)", + "output": "Abnormality of the fontanelles or cranial sutures described as any anomaly of a cranial suture, that is one of the six membrane-covered openings in the incompletely ossified skull of the fetus or newborn infant." + }, + { + "input": "Concept: 20: 57015697-57003635 (Spatial Concept)", + "output": "something described as physical location of CTSZ_Gene" + }, + { + "input": "Concept: RNA Conformation (Spatial Concept)", + "output": "Spatial Concept described as related to the secondary level of structural organization of RNA. RNA can be found in various conformations, including double- as well as single-stranded, and in loops." + }, + { + "input": "Concept: Central Nervous System Inflammatory Myofibroblastic Tumor (Inflammatory Myofibroblastic Tumor)", + "output": "Neoplastic Process described as a multinodular intermediate fibroblastic neoplasm affecting the central nervous system. It is characterized by the presence of spindle-shaped fibroblasts and myofibroblasts, and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes and plasma cells." + }, + { + "input": "Concept: FACT-C Version 4 - Additional Concern Subscale Score (Intellectual Product)", + "output": "FACT-C Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Colorectal Version 4 (FACT-C Version 4) Additional Concerns: Subscale score." + }, + { + "input": "Concept: Powder and Solvent for Emulsion for Injection Dosage Form (Combined Dosage Form)", + "output": "Combined Dosage Form described as sterile powder and sterile solvent intended for the preparation of an emulsion for injection by mixing the powder and the solvent." + }, + { + "input": "Concept: High maternal serum alpha-fetoprotein (Abnormal maternal serum screening)", + "output": "Abnormal maternal serum screening described as an abnormally high concentration of serum alpha-fetoprotein as compared to normal values for gestational-age." + }, + { + "input": "Concept: uterine sarcoma, stage II (sarcoma of uterus staging)", + "output": "sarcoma of uterus staging described as stage II uterine sarcoma is divided into stages IIA and IIB based on how far the cancer has spread into the cervix. In stage IIA, cancer has spread to the glands where the cervix and uterus meet. In stage IIB, cancer has spread into the connective tissue of the cervix." + }, + { + "input": "Concept: Electrosurgical Current Monitors, Laparoscopic (Medical Device)", + "output": "Monitors, Electrical Safety, Electrosurgery described as electrical safety electrosurgical monitors designed to assess the leakage current due to capacitive coupling and/or failure of the insulation of the active electrode of a monopolar electrosurgical unit (ESU) during laparoscopic surgery. These monitors typically consist of a monitoring unit, a conductive shield for the active electrosurgical electrode, and an alarm that is activated when the radio frequency (RF) current exceeds a predetermined value; usually the ESU is automatically deactivated simultaneously." + }, + { + "input": "Concept: circulatory assist (Operative Surgical Procedures)", + "output": "Operative Surgical Procedures described as surgical support techniques that with pumping aids the natural activity of the heart." + }, + { + "input": "Concept: ENTITY 2 (Geographic Area)", + "output": "Geographic Locations described as a geopolitical entity designated by the Geopolitical Entities, Names, anc Codes Standard (GENC)." + }, + { + "input": "Concept: Classical Mechanics (Physics)", + "output": "something described as its fundamental principle is that any physical system can be decomposed into a collection of simple independent local elements each of which interacts only with its immediate neighbors. In classical mechanics a complete description of any physical system is supposed to be specified by giving the values of the various fields (e.g., the electric field, the magnetic field, etc.) at each of the relevant spacetime points." + }, + { + "input": "Concept: EGFR c.2319 2320insAACCCCCAC (Cell or Molecular Dysfunction)", + "output": "Cell or Molecular Dysfunction described as an insertion of nine nucleotides, AACCCCCAC, between position 2319 and 2320 of the coding sequence of the EGFR gene." + }, + { + "input": "Concept: ARTERITIS, TEMPORAL (Arterial infections and inflammations)", + "output": "Central nervous system vascular disorders NEC described as an autoimmune, systemic, giant cell granulomatous arteritis predominantly involving the arteries that supply blood to the central nervous system, head and eyes. Superficial arteries of the scalp that are involved tend to be enlarged and tender. Signs and symptoms include headaches, myalgias, visual disturbances, and skin necrosis." + }, + { + "input": "Concept: Vaginal Cancer FIGO Stage II (Vaginal Cancer Pathologic Primary Tumor TNM Finding v8)", + "output": "Finding described as vaginal cancer with tumor invading paravaginal tissues but not to pelvic sidewall." + }, + { + "input": "Concept: Howell-Jolly Body Measurement (Laboratory Procedure)", + "output": "Laboratory Procedure described as a measurement of the Howell-Jolly bodies (spherical, blue-black condensed DNA inclusions within the body of a red blood cell that appear under Wright-stain) in a biological specimen." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, RHD (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)", + "output": "Medical Device described as molecular assay reagents intended to identify mutations in the Rh blood group D antigen (RHD) gene, located at chromosome 1p36.11, which encodes the protein blood group Rh(D) polypeptide. Incompatibility between maternal and fetal RHD genotype has been associated with hemolytic disease of the fetus or newborn due to isoimmunization." + }, + { + "input": "Concept: Erysipelas in swine (Disease or Syndrome)", + "output": "Swine Diseases described as an acute and chronic contagious disease of young pigs caused by Erysipelothrix insidiosa." + }, + { + "input": "Concept: dilTIAZem (Calcium Channel Blockers)", + "output": "Benzothiazepine described as a benzothiazepine derivative with anti-hypertensive, antiarrhythmic properties. Diltiazem blocks voltage-sensitive calcium channels in the blood vessels, by inhibiting the ion-control gating mechanisms, thereby preventing calcium levels increase by other revenues. Alternatively, it has been suggested that this agent also interferes with the release of calcium from the sarcoplasmic reticulum and inhibits the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. The overall low calcium levels leads to dilatation of the main coronary and systemic arteries and decreasing myocardial contractility, decreased peripheral arterial resistance, improved oxygen delivery to the myocardial tissue, and decreased cardiac output." + }, + { + "input": "Concept: WD5D5 01 (Intellectual Product)", + "output": "WHODAS 2.0 36-item Version Interviewer-administered Questionnaire Question described as world Health Organization Disability Assessment Schedule 2.0 - 36-Item Interviewer - In the past 30 days, on how many days did you reduce or completely miss household work because of your health condition?" + }, + { + "input": "Concept: hyphal septin band (Cell Component)", + "output": "something described as a septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously." + }, + { + "input": "Concept: conditionCode (Code)", + "output": "Code described as a coded value specifying the state of being of an entity." + }, + { + "input": "Concept: Fireman (Emergency Responders)", + "output": "Occupation or Discipline described as professional or volunteer members of a fire department who are trained to suppress fire and respond to related emergency." + }, + { + "input": "Concept: Transitional Epithelial Cells Measurement (Epithelial cell count)", + "output": "something described as a measurement of the transitional epithelial cells present in a biological specimen." + }, + { + "input": "Concept: Y-Linked Genetic Diseases (Genetic Diseases, Inborn)", + "output": "Genetic Diseases, Inborn described as genetic diseases that are linked to mutant ALLELES on the Y CHROMOSOME in humans (Y CHROMOSOME, HUMAN) or the Y chromosome in other species. Included here are animal models of human Y-linked diseases." + }, + { + "input": "Concept: RihB (hydrolase activity, hydrolyzing N-glycosyl compounds)", + "output": "Molecular Function described as catalysis of the reaction: an N-D-ribosylpyrimidine + H2O = D-ribose + a pyrimidine." + }, + { + "input": "Concept: Anti-HER3 Monoclonal Antibody GSK2849330 (Immunologic Factor)", + "output": "Amino Acid, Peptide, or Protein described as a monoclonal antibody directed against the human epidermal growth factor receptor 3 (HER3; ERBB3) with potential antineoplastic activity. Anti-HER3 monoclonal antibody GSK2849330 binds to HER3 and inhibits its activation. This may prevent HER3-mediated signaling and inhibit HER3-dependent tumor cell proliferation and differentiation. HER3, a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, is frequently overexpressed in tumors and is associated with poor prognosis and drug resistance; it has no active kinase domain but is activated through heterodimerization with other members of the EGFR receptor family, such as HER2." + }, + { + "input": "Concept: Carcinoma of the Eyelid pT2a TNM Finding v7 (Carcinoma of the Eyelid Pathologic Primary Tumor TNM Finding v7)", + "output": "Carcinoma of the Eyelid Pathologic Primary Tumor TNM Finding v7 described as carcinoma of the eyelid with tumor measuring more than 5 mm, but not more than 10 mm in greatest dimension. Or, any tumor invading the tarsal plate or eyelid margin." + }, + { + "input": "Concept: Grade 4 Gallbladder Infection, CTCAE (Finding)", + "output": "something described as life-threatening consequences; urgent intervention indicated" + }, + { + "input": "Concept: FACT/GOG-NTX Version 4 - I Worry About Dying (Intellectual Product)", + "output": "something described as functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity Version 4 - Emotional Well-Being: I worry about dying." + }, + { + "input": "Concept: cleavage between 5.8S rRNA and 2S rRNA of tetracistronic rRNA transcript (Genetic Function)", + "output": "Genetic Function described as endonucleolytic cleavage between the 5.8S rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." + }, + { + "input": "Concept: obsolete anaphylaxis (Anaphylactic and anaphylactoid responses)", + "output": "Anaphylactic and anaphylactoid responses described as an acute, severe multi-systemic allergic reaction that may include itching, hives, angioedema, abdominal pain, vomiting, diarrhea, breathing and swallowing difficulties, and hypotension which may progress to shock and death." + }, + { + "input": "Concept: 1,3-Propanediamine, N-(2,3-dihydro-1H-inden-2-yl)-N',N'-diethyl-N-phenyl- (Pharmacologic Substance)", + "output": "something described as a class Ib anti-arrhythmia agent used to manage ventricular and supraventricular arrhythmias." + }, + { + "input": "Concept: Turkey adenovirus 3 (Turkey adenovirus A)", + "output": "Turkey adenovirus A described as a serotype of Turkey adenovirus A." + }, + { + "input": "Concept: Screw Device (Manufactured Object)", + "output": "something described as a fastener device with a tapered threaded shaft and a head designed to engage a drive device." + }, + { + "input": "Concept: Q-LES-Q - Free of Worry of Physical Health (Q-LES-Q Questionnaire Question)", + "output": "Q-LES-Q Questionnaire Question described as quality Of Life Enjoyment And Satisfaction Questionnaire (Q-LES-Q) With regard to your physical health, during the past week how much of the time have you: been free of worry about your physical health?" + }, + { + "input": "Concept: NCL protein, human (Biologically Active Substance)", + "output": "Amino Acid, Peptide, or Protein described as nucleolin (710 aa, ~77 kDa) is encoded by the human NCL gene. This protein is involved in both chromatin decondensation and ribosome assembly." + }, + { + "input": "Concept: Ig C2-set Domains (Immunoglobulin Domains)", + "output": "Immunoglobulin Domains described as the Ig constant chain domains and a single extracellular domain in each type of MHC chains are homologous and approximately 100 amino acids long, and include a conserved intra-domain disulfide bond. Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. This subfamily is the C-2-type and includes glycoproteins and other unrelated proteins with immunoglobulin domains eg. carcinoembryonic antigens and fibroblast growth factor receptors." + }, + { + "input": "Concept: Vogts' areas (Cerebral cortex)", + "output": "Cerebral cortex described as a classification of human cerebral cortex into more than 200 subdivisions based on cytoarchitecture and myeloarchitecture by Cecile and Oskar Vogt ( Carpenter-1983 ). It also refers to a classification of lateral and dorsal cortical areas of the frontal lobe, the parietal lobe and the lateral temporal lobe of the guenon (Cercopithecus) into some 36 areas ( Vogts-1919 ). Cecile and Oskar Vogt worked in the same institute as Brodmann and Mauss ( Brodmann-1905, Brodmann-1909, Mauss-1908 ). Their classification scheme for cortical areas in the guenon was an extension of the segmentations produced by those authors. While the maps of Brodmann and Mauss were based on three brain specimens each, the Vogts' study included some 100 specimens. Their illustration of cortical areas differed from those of Brodmann in that they subdivided many of Brodmann's areas, they did not draw boundaries hidden in sulci on the surface of the brain, and their report included an extensive description of the character of the transitions from one cortical area to another." + }, + { + "input": "Concept: 3-Beta-Hydroxysteroid Dehydrogenase Deficiency (Disease or Syndrome)", + "output": "Congenital adrenal hyperplasia described as decreased activity of the enzyme 3-beta-hydroxysteroid dehydrogenase, associated with mutation(s) in the HSD3B2 gene. The lack of activity of this enzyme produces a type of congenital adrenal hyperplasia." + }, + { + "input": "Concept: inactivation of X chromosome by genetic imprinting (regulation of gene expression by genetic imprinting)", + "output": "Genetic Function described as compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex by genetic imprinting." + }, + { + "input": "Concept: discharges (Body Fluids)", + "output": "Body Substance described as in medicine, a fluid that comes out of the body. Discharge can be normal or a sign of disease. Discharge also means release of a patient from care." + }, + { + "input": "Concept: Day Imputed (Temporal Concept)", + "output": "Imputed Date described as day Imputed: Day is imputed." + }, + { + "input": "Concept: >10 days within the onset of initial symptoms (Finding)", + "output": "Finding described as an indication that the patient was given treatment for Kawasaki disease beyond 10 days of the onset of initial symptoms." + }, + { + "input": "Concept: coenzyme B biosynthesis (coenzyme biosynthetic process)", + "output": "coenzyme biosynthetic process described as the chemical reactions and pathways resulting in the formation of coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." + }, + { + "input": "Concept: Mycobacterium tuberculosis IgA Antibody (Immunologic Tests)", + "output": "Laboratory Procedure described as the determination of the amount of Mycobacterium tuberculosis IgA antibody present in a sample." + }, + { + "input": "Concept: guanosine 5'-phosphate reductase activity (oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor)", + "output": "Molecular Function described as catalysis of the reaction: IMP + NADP(+) + NH(4)(+) = GMP + 2 H(+) + NADPH." + }, + { + "input": "Concept: EMO1-Anger Responded as Sadness (ERT Functional Test Question)", + "output": "ERT Functional Test Question described as emotion Recognition - Number of anger stimuli responded to as sadness." + }, + { + "input": "Concept: Exchange Resins, Ion (Medicinal product categorized by disposition)", + "output": "Foods, vitamins, electrolytes and inorganic salts described as high molecular weight, insoluble polymers which contain functional groups that are capable of undergoing exchange reactions (ION EXCHANGE) with either cations or anions." + }, + { + "input": "Concept: Tubular Dysgenesis related to Fetal Exposure to ACE Inhibitor or ARB (Finding)", + "output": "something described as tubular dysgenesis resulting from maternal exposure to a class of drugs known as angiotensin converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARB)." + }, + { + "input": "Concept: Free and Sovereign State of Tamaulipas (Mexican State)", + "output": "Geographic Area described as a state in north eastern Mexico on the Gulf of Mexico. Its capital is Ciudad Victoria." + }, + { + "input": "Concept: Nanogram per 24 hours (Quantitative Concept)", + "output": "SI units of mass per unit time described as a unit of mass flow rate equal to one nanogram per day." + }, + { + "input": "Concept: Zone electrophoresis measurement, NOS (Immunochemistry assay)", + "output": "field separation method described as a kind of electrochemical process used to separate charged particles" + }, + { + "input": "Concept: morphine receptor activity (Molecular Function)", + "output": "opioid receptor activity described as combining with morphine (17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol), and transmitting the signal across the membrane by activating an associated G-protein." + }, + { + "input": "Concept: Receptor, IGF I (Amino Acid, Peptide, or Protein)", + "output": "Enzyme described as a protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The beta subunit contains an intrinsic tyrosine kinase domain." + }, + { + "input": "Concept: Percent Change From Nadir in Sum of Diameter (Mass Measurement)", + "output": "something described as the (current sum of diameters minus the lowest sum of diameters previously recorded) divided by the lowest sum of diameters previously recorded, multiplied by 100." + }, + { + "input": "Concept: test rheumatoid factor (Intravascular Autoantibody Test)", + "output": "In-vitro immunologic test described as a measurement of the rheumatoid factor antibody in a biological specimen." + }, + { + "input": "Concept: Subglottic Carcinoma pT4 TNM Finding v8 (Finding)", + "output": "Finding described as subglottic cancer with moderately advanced or very advanced disease." + }, + { + "input": "Concept: MAGE-1 Antigen (Tumor Antigens)", + "output": "Tumor Antigens described as a cancer specific antigen expressed by the melanoma antigen gene." + }, + { + "input": "Concept: equivalence trial (Research Activity)", + "output": "Randomized Controlled Trial described as a trial with the primary objective of showing that the response to two or more treatments differs by an amount that is clinically unimportant. NOTE: This is usually demonstrated by showing that the true treatment difference is likely to lie between a lower and an upper equivalence margin of clinically acceptable differences." + }, + { + "input": "Concept: Chief Complaint was Witnessed (Chief complaint)", + "output": "Chief complaint described as an indication that the chief complaint was witnessed." + }, + { + "input": "Concept: Bio-Specimen (Specimen)", + "output": "Body Substance described as any material sample taken from a biological entity for testing, diagnostic, propagation, treatment or research purposes, including a sample obtained from a living organism or taken from the biological object after halting of all its life functions. Biospecimen can contain one or more components including but not limited to cellular molecules, cells, tissues, organs, body fluids, embryos, and body excretory products." + }, + { + "input": "Concept: gallium Ga 68-NODAGA-ZIGF-1R:4\uff1a40 (Diagnostic Reagent)", + "output": "Pharmacologic Substance described as a radiolabeled recombinant insulin-like growth factor 1 receptor (IGF-1R; IGF1R)-specific affibody ligand composed of an IGF1R-targeting protein, the anti-IGF1R affibody ZIGF-1R:4:40 with an acetylated cysteine (Ac-Cys) at the N terminal of the affibody, that is site-specifically conjugated with the chelating agent NODAGA (1,4,7-triazacyclononane,1-glutaric acid-4,7-acetic acid), and labeled with the radioisotope gallium Ga 68, with potential use for imaging IGF1R-expressing tumor cells upon positron emission tomography (PET). Upon administration of gallium Ga 68-NODAGA-ZIGF-1R:4:40, the ZIGF-1R:4:40 affibody molecule moiety targets and binds to IGF1R expressed on various tumor cell types. Upon PET, IGF1R-expressing tumor cells can be visualized. IGF1R, frequently overexpressed in cancers, plays important roles in cell proliferation, survival, adhesion, migration, and differentiation. The affibody protein scaffold is based on the Z-domain, which is derived from one of the immunoglobulin (Ig) G-binding domains of staphylococcal protein A. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C132030\" active clinical trials using this agent." + }, + { + "input": "Concept: Postnatal deceleration of head circumference (Head)", + "output": "something described as head circumference which falls below 2 standard deviations below the mean for age and gender because of insufficient head growth after birth." + }, + { + "input": "Concept: client (Manufactured Object)", + "output": "Computers described as a program that makes a service request of another program, usually running on a server, that fulfills the request. Web browsers (such as Firefox and Microsoft explorer) are clients that request HTML files from web servers." + }, + { + "input": "Concept: WHODAS 2.0 36-item Version Self-administered - Emotionally Affected by Health (Intellectual Product)", + "output": "WHODAS 2.0 36-item Version Self-administered Questionnaire Question described as world Health Organization Disability Assessment Schedule 2.0 36-item Version Self-administered (WHODAS 2.0 36-item Version Self-administered) In the past 30 days: How much have you been emotionally affected by your health condition?" + }, + { + "input": "Concept: glutathionylspermidine amidohydrolase (spermidine-forming) activity (Molecular Function)", + "output": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides described as catalysis of the reaction: N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + H2O = gamma-L-glutamyl-L-cysteinyl-glycine + spermidine." + }, + { + "input": "Concept: KIAA0204 (Gene or Genome)", + "output": "something described as human SLK wild-type allele is located in the vicinity of 10q25.1 and is approximately 62 kb in length. This allele, which encodes STE20-like serine/threonine-protein kinase protein, plays a role in both apoptosis and protein phosphorylation." + }, + { + "input": "Concept: cellular response to cation stress (cellular response to salt stress)", + "output": "response to cation stress described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment." + }, + { + "input": "Concept: Heat-Stable Enterotoxin Receptor Antibody (Antibodies)", + "output": "Antibodies described as any immunoglobulin that recognizes heat-stable enterotoxin receptor." + }, + { + "input": "Concept: Lymphoreticuloses, Inoculative (Disease or Syndrome)", + "output": "Other zoonotic bacterial diseases, not elsewhere classified described as a bacterial infection caused by Bartonella henselae. It is transmitted to humans from a scratch, bite, or lick from a cat. A blister or a bump appears on the skin following the scratch or bite. Subsequently, there is lymph node enlargement around the scratch or bite site. The lymph node enlargement most often occurs under the arm or the neck. Some patients experience fever, fatigue, headaches or sore throat as well." + }, + { + "input": "Concept: ANESTHETIZED LETHAL INJECTION INTRAVENOUS EXSANGUINATION (Euthanasia Method)", + "output": "something described as a method of euthanasia whereby a subject is anesthetized, a lethal chemical is administered by intravenous injection and the body is drained of blood." + }, + { + "input": "Concept: Ethanesulfonic acid, 2-(((3alpha,5beta)-3-hydroxy-24-oxocholan-24-yl)amino)- (Organic Chemical)", + "output": "Organic Chemical described as a bile salt formed in the liver from lithocholic acid conjugation with taurine, usually as the sodium salt. It solubilizes fats for absorption and is itself absorbed. It is a cholagogue and choleretic." + }, + { + "input": "Concept: Invasive Hydatidiform Moles (Neoplasm of uncertain behavior of female genital organ)", + "output": "Hydatidiform Mole described as a uterine tumor derived from persistent gestational TROPHOBLASTS, most likely after a molar pregnancy (HYDATIDIFORM MOLE). Invasive hyadatiform mole develops in about 15% of patients after evacuation of a complete mole and less frequently after other types of gestation. It may perforate the MYOMETRIUM and erode uterine vessels causing hemorrhage." + }, + { + "input": "Concept: BI2536 (Mitotic Enzyme Modulator)", + "output": "something described as a substance being studied in the treatment of cancer. It prevents cells from dividing and may block the growth of some tumors. It is a type of mitotic inhibitor." + }, + { + "input": "Concept: Grade 2 Infant Irritability, Adverse Event (Finding)", + "output": "Finding described as an adverse event in a newborn characterized by moderate irritability, minor changes in feeding and sleeping behavior, requiring minor additional care (e.g. occasional analgesics)." + }, + { + "input": "Concept: Familial nonmedullary thyroid carcinoma (Adenocarcinoma of head and neck)", + "output": "something described as a rare hereditary nonmedullary thyroid carcinoma characterized by the presence of differentiated thyroid cancer of follicular cell origin in two or more first-degree relatives, in the absence of other familial tumor syndromes or radiation exposure. Frequent capsular invasion is observed. Biopsy reveals multicentric tumors with multiple adenomatous nodules with or without oxyphilia and follicular or papillary carcinoma histology." + }, + { + "input": "Concept: I almost always have severe trouble with my breathing (Intellectual Product)", + "output": "something described as a response indicating that an individual almost always has or had severe trouble with their breathing." + }, + { + "input": "Concept: Plastic Surgery Procedure (Therapeutic or Preventive Procedure)", + "output": "Surgical Procedure by Method described as branch of surgery concerned with restoration, reconstruction, or improvement of defective, damaged, or missing structures." + }, + { + "input": "Concept: angioendothelioma (Neoplasm, uncertain whether benign or malignant)", + "output": "Hemangioendothelioma described as a neoplasm derived from blood vessels, characterized by numerous prominent endothelial cells that occur singly, in aggregates, and as the lining of congeries of vascular tubes or channels. Hemangioendotheliomas are relatively rare and are of intermediate malignancy (between benign hemangiomas and conventional angiosarcomas). They affect men and women about equally and rarely develop in childhood." + }, + { + "input": "Concept: Hexadecatrienoic Acid n-3 (omega-3 fatty acids)", + "output": "Hexadecatrienoic Acid described as a polyunsaturated long-chain fatty acid with a 16-carbon backbone and 3 double bonds originating from the 3rd, 6th and 9th positions from the methyl end." + }, + { + "input": "Concept: 9-beta-stemod-13(17)-ene oxidase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)", + "output": "Molecular Function described as catalysis of the reaction: stemod-13(17)-ene + 3 NADPH + 3 O2 + 3 H+ <=> 9beta-stemod-13(17)-en-19-oate + 3 NADP + 4 H2O." + }, + { + "input": "Concept: general transcription factor activity (Molecular Function)", + "output": "transcription regulator activity described as an activity that contributes to transcription start site selection and transcription initiation." + }, + { + "input": "Concept: Pediatric Quality of Life Neuromuscular Module Acute Version 3.0 Parent of Toddler Questionnaire (Intellectual Product)", + "output": "Intellectual Product described as a 25-item disease specific complement to the Pediatric Quality of Life Inventory instrument published by Sarah Davis et al. in 2010 that utilizes a 5-point Likert scale to measure three dimensions of parent reported health related quality of life over the past seven days in children ages 2 to 4 years with neuromuscular disorders." + }, + { + "input": "Concept: Cesium-137 (Cesium and cesium compound)", + "output": "something described as a radioactive isotope of cesium with an atomic mass of 139 and potential application in radiotherapy. Cesium Cs 137 is prevalent due to its spontaneous production, which occurs as a result of nuclear fission of other radioactive materials, such as uranium and plutonium. This radionuclide has a relatively long half-life, 30 years, and decays by emitting beta particles. Both Cs 137 and its metastable nuclear isomer, barium-137m, emit gamma radiation of moderate energy and so are used in sterilization procedures in the food industry or in hospital environments. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C68812\" active clinical trials using this agent." + }, + { + "input": "Concept: Ampulla of Vater Cancer pT1 TNM Finding v7 (Finding)", + "output": "Finding described as ampulla of Vater cancer with tumor limited to ampulla of Vater or sphincter of Oddi." + }, + { + "input": "Concept: Global Alignment of Immunization safety Assessment in pregnancy Level 2 Assessment of Preterm Labor (GAIA Preterm Labor Levels of Diagnostic Certainty)", + "output": "Intellectual Product described as level 2 Assessment of Preterm Labor is defined by three criteria: first, confirmed delivery of a fetus between 24 0/7 and 36 6/7 weeks gestation; second, greater than four uterine contractions per hour as determined by a tocodynometer OR by clinical assessment; third, documented change in length or dilation of the cervix by physical examination, with clinical criteria obtained by digital examination, including: a) Cervical dilation of two centimeters or more at the internal os; b) Cervical length of one centimeter or less; c) greater than or equal to 50% effacement of the cervix." + }, + { + "input": "Concept: cells leydigs (Interstitial tissue of testis)", + "output": "Endocrine-Stromal Cell described as epithelioid cells constituting the endocrine tissue of the testis, which elaborate androgens, chiefly testosterone." + }, + { + "input": "Concept: VZFPS (Predicted Volume of Distribution of Absorbed Fraction)", + "output": "Predicted Volume of Distribution of Absorbed Fraction described as the predicted volume of distribution of the absorbed fraction associated with the terminal slope following extravascular administration, where F equals the fraction of dose absorbed, divided by the surface area." + }, + { + "input": "Concept: Cushingoid (Adrenal Gland Hyperfunction)", + "output": "Mental disorders due to a general medical condition NEC described as a constellation of signs and symptoms caused by an excess of glucocorticoids. Classic features include moon facies, buffalo hump, obesity, striae and adiposity." + }, + { + "input": "Concept: Excision of appendix testis (TESTIS AND EPIDIDYMIS: EXCISIONS)", + "output": "TESTIS AND EPIDIDYMIS: EXCISIONS described as excision of appendix of testis-vestige of Mullerian duct" + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, MUT (Medical Device)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation described as molecular assay reagents intended to identify mutations in the methylmalonyl coenzyme A mutase (MUT) gene, located at chromosome 6p21, which encodes for the methylmalonyl Coenzyme A (CoA) mutase enzyme that is active in mitochondria. Methylmalonyl CoA mutase is responsible for the breakdown of isoleucine, methionine, threonine, and valine as well as lipids and cholesterol. Mutations at this locus have been identified in patients with methylmalonic acidemia (MMA)." + }, + { + "input": "Concept: NCI CTEP Simple Disease Classification Immune Disorder (excluding AIDS and malignancy), Miscellaneous Sub-Category Terminology (Intellectual Product)", + "output": "Intellectual Product described as immune Disorder (excluding AIDS and malignancy), Miscellaneous is an NCI Cancer Therapeutic Evaluation Program (CTEP) Simplified Disease Classification (SDC) category used to organize cancer-related disease coding that harmonizes with and supports reporting based on the global standard Medical Dictionary for Drug Regulatory Reporting (MedDRA) terminology." + }, + { + "input": "Concept: collagen fibril binding (Molecular Function)", + "output": "protein-containing complex binding described as interacting selectively and non-covalently with a collagen fibril." + }, + { + "input": "Concept: SYSTEM, X-RAY, PHOTOFLUOROGRAPHIC (Medical Device)", + "output": "something described as a photofluorographic X-ray system is a device that includes a fluoroscopic X-ray unit and a camera intended to be used to produce, then photograph, a fluoroscopic image of the body. This generic type of device may include signal analysis and display equipment, patient and equipment supports, component parts, and accessories." + }, + { + "input": "Concept: Secondary Cell Culture (Laboratory Procedure)", + "output": "something described as propagation of cell that have already been established in culture." + }, + { + "input": "Concept: 1p36.12 (Cell Component)", + "output": "Cell Component described as a chromosome band present on 1p" + }, + { + "input": "Concept: Product containing benzoic acid (Skin antifungal agent, NOS)", + "output": "something described as a fungistatic compound that is widely used as a food preservative. It is conjugated to GLYCINE in the liver and excreted as hippuric acid." + }, + { + "input": "Concept: TF (Domain)", + "output": "Intellectual Product described as a subject domain utilized for the submission of information encompassing and representing data, vocabulary or records related to tumor findings." + }, + { + "input": "Concept: ANGINA ATYPICAL (Disease or Syndrome)", + "output": "Angina Pectoris described as angina pectoris which does not have associated classical symptoms of chest pain. Symptoms may include weakness, nausea, or sweating." + }, + { + "input": "Concept: Fatigue Prevents Sustained Physical Functioning (Findings-Based Question)", + "output": "Findings-Based Question described as a question about whether an individual's fatigue prevents or prevented sustained physical functioning." + }, + { + "input": "Concept: MIC95R (Laboratory test finding)", + "output": "Laboratory test finding described as a reference control sample response based on the concentration of a specific drug expected to produce 95 percent inhibition on the enzymatic activity of a microbial organism." + }, + { + "input": "Concept: Usual Severity Lack of Appetite (Clinical or Research Assessment Question)", + "output": "Clinical or Research Assessment Question described as a question about the usual severity of an individual's appetite." + }, + { + "input": "Concept: protein amino acid galactosylation in Golgi (protein glycosylation in Golgi)", + "output": "something described as the addition of a galactose unit to a protein amino acid in any compartment of the Golgi apparatus." + }, + { + "input": "Concept: Computer Specialists (Professional or Occupational Group)", + "output": "Professional or Occupational Group described as workers who provide help and advice to people and organizations using computer software or equipment. Some support information technology (IT) employees and others assist non-IT users who are having computer problems." + }, + { + "input": "Concept: TIPRANAVIR (Retroviral protease inhibitor)", + "output": "Drug allergens described as a non-peptidomimetic agent that inhibits both wild type and drug resistant forms of human immunodeficiency virus (HIV) protease." + }, + { + "input": "Concept: Regimen Used to Treat Malignant Anal Neoplasm (Therapeutic or Preventive Procedure)", + "output": "Chemo/immuno/hormone Therapy Regimen described as any regimen that can be used for the treatment of anal carcinoma." + }, + { + "input": "Concept: dermatomucosomyositis (Multiple Organ Syndromes NEC)", + "output": "Rheumatic and Collagen Muscle Diseases and Syndromes described as inflammation of the skin and muscle." + }, + { + "input": "Concept: double-stranded DNA specific exodeoxyribonuclease activity (Genetic Function)", + "output": "something described as catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule." + }, + { + "input": "Concept: N Acylneuraminate Glycohydrolases (Inborn errors metabolism lysosomal)", + "output": "Enzyme described as do not confuse with EC 3.2.1.129 or EC 3.2.1.138." + }, + { + "input": "Concept: sulfurated eukaryotic molybdenum cofactor(2-) metabolism (Molecular Function)", + "output": "something described as the chemical reactions and pathways involving sulfurated eukaryotic molybdenum cofactor(2-)." + }, + { + "input": "Concept: Stents, Paranasal Sinus (Medical Device)", + "output": "something described as stents designed for deployment into one of the paranasal sinus ducts to provide support and/or maintain patency. These stents may consist of a metallic or, more frequently, plastic tubes. They are available in several different shapes and sizes according to the sinus on which they are deployed (i.e., frontal, ethmoid, or sphenoid) and/or include a self-retention mechanism that may incorporate sutures to prevent migration. Paranasal sinus stents are intended for temporary (e.g., two weeks) ventilation and drainage of fluids from the sinus. They may be manually implanted or delivered using dedicated instruments and/or stent delivery kits (e.g., catheters, deployment guides) and then manually removed after that period of time. The stents are mainly used after functional endoscopic sinus surgery (FESS). Absorbable and/or drug eluting stents are also available." + }, + { + "input": "Concept: dedifferentiation (Cell Function)", + "output": "Cell Function described as the process in which a specialized structure (cell, tissue or organ) loses structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these structures can revert back to the features of their ancestors." + }, + { + "input": "Concept: Stage IV Nasopharyngeal Throat Cancer (Stage IV Pharynx Carcinoma)", + "output": "Nasopharyngeal Carcinoma by AJCC v8 Stage described as stage IV includes: IVA: (T4, N0, M0); (T4, N1, M0); (T4, N2, M0); (Any T, N3, M0); IVB (Any T, Any N, M1). T4: Tumor with intracranial extension, involvement of cranial nerves, hypopharynx, orbit, parotid gland, and/or extensive soft tissue infiltration beyond the lateral surface of the lateral pterygoid muscle. N0: No regional lymph node metastasis. N1: Tumor with unilateral metastasis in cervical lymph node(s), and/or unilateral or bilateral metastasis in retropharyngeal lymph node(s), 6 cm or smaller in greatest dimension, above the caudal border of cricoid cartilage. N2: Tumor with bilateral metastasis in cervical lymph node(s), 6 cm or smaller in greatest dimension, above the caudal border of cricoid cartilage. N3: Tumor with unilateral or bilateral metastasis in cervical lymph node(s), larger than 6 cm in greatest dimension, and/or extension below the caudal border of cricoid cartilage. M0: No distant metastasis. M1: Distant metastasis." + }, + { + "input": "Concept: Academic Overachievement (Student Characteristics & Academic Environment)", + "output": "Student Characteristics & Academic Environment described as academic achievement greater than that anticipated on basis of one's scholastic aptitude score or individual intelligence." + }, + { + "input": "Concept: PI0105 (PI Questionnaire Question)", + "output": "PI Questionnaire Question described as pain Intensity - Least pain intensity for various time periods of evaluation." + }, + { + "input": "Concept: Cranial Nerve, Fifth (Regional peripheral nerve)", + "output": "Peripheral Nervous System described as one of twelve cranial nerves that attach to the brain and pass out of the cranial cavity through openings at the base of the cranium. The nerve is composed of axons to and from several trigeminal nuclei in the midbrain and hindbrain. The bundles of axons located within the brain are referred to as trigeminal nerve fibers, tracts and roots. Defined on the basis of connectivity the trigeminal nerve includes both the trigeminal nerve fibers within the brain and the nerve trunks outside" + }, + { + "input": "Concept: positive regulation of amine degradation (positive regulation of cellular catabolic process)", + "output": "something described as any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways leading to the breakdown of amines." + }, + { + "input": "Concept: NUMSLICE (Quantitative Concept)", + "output": "Quantity described as the number of planar cross-sections in an imaging sequence; each slice corresponds to a single image." + }, + { + "input": "Concept: Autolysis (Postmortem Changes)", + "output": "something described as the destruction of organism cells or tissues by the organism's own enzymes or processes." + }, + { + "input": "Concept: OAB-q - Carefully Plan Your Commute (OAB-q Questionnaire Question)", + "output": "something described as the Overactive Bladder Questionnaire - Made you carefully plan your commute?" + }, + { + "input": "Concept: chemotherapy intrathecal (Regional chemotherapy)", + "output": "Compartmental Treatment described as treatment in which anticancer drugs are injected into the fluid-filled space between the thin layers of tissue that cover the brain and spinal cord." + }, + { + "input": "Concept: Zirconium Zr 89-labeled Anti-CA19-9 Monoclonal Antibody 5B1 (Radioimmunoconjugates)", + "output": "Indicator, Reagent, or Diagnostic Aid described as a radioimmunoconjugate comprised of the recombinant human monoclonal antibody against the carbohydrate antigen sialyl-Lewis a (carbohydrate antigen 19-9; CA19-9) conjugated to the chelator desferrioxamine (DFO) and labeled with the radioisotope zirconium Zr 89 (Zr 89), with radioisotopic activity and potential use as an imaging agent in positron emission tomography (PET). The antibody moiety of zirconium Zr 89 anti-CA19-9 monoclonal antibody 5B1 targets and binds to CA19-9 expressing-tumor cells. Upon binding, internalization and proteolysis, the radioisotope moiety may be detected using PET, thus allowing imaging and quantification of CA19-9-expressing tumor cells. CA19-9, overexpressed on a number of different tumor cell types, plays a key role in tumor cell survival and metastasis." + }, + { + "input": "Concept: Monitors, Bedside, Noninvasive Blood Pressure (Medical Device)", + "output": "Medical Device described as blood pressure monitors designed for quasi-continuous noninvasive measurement and display of blood pressure values intermittently or at preset intervals and are hard-wired to the patient at the bedside. These monitors are based on external, noninvasive sensors working in a way similar to automated sphygmomanometers; they typically consist of an electronic unit that acquires and/or processes the signal from a transducer located inside tubing attached to a pneumatic cuff wrapped around the patient's arm. This transducer detects blood pressure fluctuations and transmits this information to the physiologic monitor which displays the values of the electrical signals from the sensor as maximum and minimum values of blood pressure (i.e., systolic and diastolic pressures); these monitors also display a mean pressure calculated from the measured values using a software algorithm. Most noninvasive blood pressure (NIBP) monitors can also include measurement of the pulse rate and alarm if the patient blood pressure or pulse rate are out of preset limits." + }, + { + "input": "Concept: cataract-hypertrichosis-mental retardation (CAHMR) syndrome (Hereditary disorder of the visual system)", + "output": "Intellectual Disability described as a syndrome consisting mainly of cataracts, hypertrichosis, and mental retardation." + }, + { + "input": "Concept: intrathecal catheters (Nervous system catheter)", + "output": "Spinal catheter described as spinal catheters introduced into the subarachnoid space through the membranes (sheath or \"theca\") covering the spinal cord. These catheters are introduced using special needles, and their distal tip is advanced into the subarachnoid space to the desired spinal segment (e.g., lumbar). Intrathecal spinal catheters may be tunneled, using either an external injection hub or a subcutaneous port for bolus administration or infusion via an external pump; these systems are used for temporary procedures (e.g., surgery, delivery) or in patients whose life expectancy is very short. Otherwise, the epidural catheters are attached to subcutaneous implanted infusion pumps for continuous infusion in relatively long-term procedures, such as treatments of spasticity (using antispasmodic drugs such as baclofen) in spinal injured patients, or opioids (e.g., morphine) administration to cancer patients with long life expectancy. Intrathecal catheters usually employ smaller drug doses than epidural catheters." + }, + { + "input": "Concept: GROUP V PHOSPHOLIPASES A 02 (Secretory Phospholipase A2)", + "output": "Enzyme described as a subcategory of secreted phospholipases A2 that contains both a negatively charged carboxy-terminal segment and interfacial-binding region specific for PHOSPHATIDYL CHOLINE-containing membranes. This enzyme group may play a role in the release of ARACHIDONIC ACID from phospholipid membranes." + }, + { + "input": "Concept: CRQ02-Control of Breathing Problems (Intellectual Product)", + "output": "CRQ-SAS Follow-Up Administration Version Questionnaire Question described as chronic Respiratory Questionnaire Self-Administered Standardized Format (CRQ-SAS) Follow-up Administration Version - How often during the last 2 weeks did you feel you had complete control of your breathing problems?" + }, + { + "input": "Concept: OROFACIODIGITAL SYNDROME II (Musculoskeletal disorders congenital NEC)", + "output": "Multiple malformation syndrome with facial-limb defects as major feature described as a syndrome consisting mainly of orofacial and digital defects, including microcephaly, lingual defects, median cleft of the upper lip, and bony changes of the hands and feet. Psychomotor retardation has been reported in some cases." + }, + { + "input": "Concept: trichlorophenol O-methyltransferase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the reaction: S-adenosyl-L-methionine + trichlorophenol = S-adenosyl-L-homocysteine + trichloroanisole." + }, + { + "input": "Concept: missed dose units of measure (Miscellaneous Unit)", + "output": "Quantitative Concept described as the unit of measure used to quantify a missed dose of a therapeutic agent to a subject." + }, + { + "input": "Concept: protein-keratan sulfate linkage via keratan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine (Molecular Function)", + "output": "peptidyl-threonine modification described as keratan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and threonine residues." + }, + { + "input": "Concept: Aspiration, meconium (fetal or newborn aspiration)", + "output": "Lung Injury described as a serious condition in which a newborn breathes a mixture of meconium (the first intestinal discharge) and amniotic fluid into the lungs around the time of delivery. Meconium aspiration syndrome occurs in 5-10 percent of births and typically occurs when the infant is stressed, as when the infant is past its due date." + }, + { + "input": "Concept: SIQR01-Vacuum Scrub or Sweep Floors (Intellectual Product)", + "output": "Intellectual Product described as symptom Impact Questionnaire - Vacuum, scrub or sweep floors." + }, + { + "input": "Concept: Papaverine-containing product (Isoquinolines)", + "output": "Antispasmodics described as an opiate alkaloid isolated from the plant Papaver somniferum and produced synthetically. As a direct-acting smooth muscle relaxant, papaverine is not closely related to the other opium alkaloids in structure or pharmacological actions; its mechanism of action may involve the non-selective inhibition of phosphodiesterases and direct inhibition of calcium channels. This agent also exhibits antiviral activity against respiratory syncytial virus, cytomegalovirus, and HIV." + }, + { + "input": "Concept: Abnormal Cardiac Study (Finding)", + "output": "Finding described as a history of having had an abnormal cardiac study." + }, + { + "input": "Concept: FACIT-Dyspnea Scale 33 Item Bank Version - Severity: Walking 1/2 Mile (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)", + "output": "something described as functional Assessment of Chronic Illness Therapy-Dyspnea Scale 33 Item Bank (FACIT-Dyspnea Scale 33 Item Bank Version) Dyspnea Severity: Over the past 7 days, how short of breath did you get with each of these activities?: Walking 1/2 mile (almost 1 km) on flat ground at a normal speed without stopping." + }, + { + "input": "Concept: Ecm29 Proteasome Adapter and Scaffold (Amino Acid, Peptide, or Protein)", + "output": "something described as proteasome adapter and scaffold protein ECM29 (1845 aa, ~204 kDa) is encoded by the human ECPAS gene. This protein plays a role in proteasome localization and assembly." + }, + { + "input": "Concept: hepoxilin metabolism (unsaturated fatty acid metabolic process)", + "output": "something described as the chemical reactions and pathways involving hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology." + }, + { + "input": "Concept: Bombesin Receptor 2 Overexpression Positive (Receptor status)", + "output": "Laboratory or Test Result described as an indication that overexpression of GRPR has been detected in a sample." + }, + { + "input": "Concept: 3p12-q13.2 (Chromosome band)", + "output": "Chromosome band described as a chromosome band present on 3p" + }, + { + "input": "Concept: Stools, Adjustable, Anesthesiology (Anesthesia and respiratory device)", + "output": "Stools, Adjustable described as height-adjustable stools that are designed for anesthesiologist use during surgical procedures. These stools are usually metallic and may include backrest and casters; they usually do not include armrests. Some anesthesiology stools include conductive upholstery" + }, + { + "input": "Concept: interleukin-21-mediated signalling pathway (cytokine-mediated signaling pathway)", + "output": "Cell Function described as a series of molecular signals initiated by the binding of interleukin-21 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." + }, + { + "input": "Concept: Simvastatinum (Dyslipidemics, HMG CoA Reductase Inhibitors)", + "output": "lovastatin described as a kind of cholesterol- lowering drug" + }, + { + "input": "Concept: IVD Test Reagent/Kits, Serology, Bacteria, Brucella melitensis, IgG Antibody (Medical Device)", + "output": "Medical Device described as serology reagents intended to detect immunoglobulin G (IgG) antibodies to Brucella melitensis, a coccobacillus bacterium. These bacteria are an etiologic agent of brucellosis, a disease characterized by intermittent (i.e., undulant) fever." + }, + { + "input": "Concept: H2A Histone Family Member X Gene (H2AX gene)", + "output": "Gene or Genome described as human H2AX wild-type allele is located within 11q23.2-q23.3 and is approximately 2 kb in length. This allele, which encodes histone H2AX protein, is involved in the modulation of transcription, DNA replication and chromosomal stability. The allele may play a role in the regulation of both immunoglobulin class switch recombination and DNA double strand break repair." + }, + { + "input": "Concept: negative regulation of Wnt-activated signaling pathway, calcium modulating pathway (regulation of Wnt signaling pathway, calcium modulating pathway)", + "output": "negative regulation of non-canonical Wnt signaling pathway described as any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." + }, + { + "input": "Concept: Tracking Document (Intellectual Product)", + "output": "Intellectual Product described as records maintained by the regulatory affairs staff or designee, that track the Institutional Review Board (IRB)/Independent Ethics Committee (IEC) activities during the course of a clinical trial." + }, + { + "input": "Concept: Posttreatment Followup (Treatment (General))", + "output": "Treatment (General) described as periodic check-ups of patients. Usually part of a comprehensive aftercare treatment." + }, + { + "input": "Concept: Collection Containers, Aspirator/Suction Unit (Medical Device)", + "output": "Aspirator trap bottle described as containers designed to collect tissue, secretions, mucus, blood, irrigation fluids, and other debris from sources such as surgical sites, oral cavities, etc. These devices are typically able to be detached from the aspirator and may be reusable or disposable." + }, + { + "input": "Concept: Catheter guide wire, device (Medical Devices)", + "output": "Device Labeled for Single Use described as a catheter guide wire is a coiled wire that is designed to fit inside a percutaneous catheter for the purpose of directing the catheter through a blood vessel." + }, + { + "input": "Concept: Head and Neck Muscle (Muscle)", + "output": "something described as any skeletal muscled located in the head or neck." + }, + { + "input": "Concept: BPI 7711 (Epidermal growth factor receptor inhibitor)", + "output": "Epidermal growth factor receptor inhibitor described as an orally available third-generation and selective inhibitor of certain epidermal growth factor receptor (EGFR) activating mutations, including the resistance mutations T790M and L858R, as well as exon 19 deletion, with potential antineoplastic activity. Upon administration, the EGFR mutant-specific inhibitor BPI-7711 specifically and covalently binds to and inhibits selective EGFR mutations, with particularly high selectivity against the T790M mutation, which prevents EGFR mutant-mediated signaling and leads to cell death in EGFR mutant-expressing tumor cells. Compared to some other EGFR inhibitors, BPI-7711 may have therapeutic benefits in tumors with T790M-mediated drug resistance. This agent shows minimal activity against wild-type EGFR (wt EGFR), and does not cause dose-limiting toxicities that occur during the use of non-selective EGFR inhibitors, which also inhibit wt EGFR. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization." + }, + { + "input": "Concept: Sacral base unleveling (Somatic dysfunction of sacral spine)", + "output": "Body position described as with the patient in a standing or seated position, any deviation of the sacral base from the horizontal in a coronal plane. Generally, the rotation of the sacrum about an anterior-posterior axis." + }, + { + "input": "Concept: pg/mL/kg (Unit of concentration)", + "output": "Unit of concentration described as picograms per milliliter (concentration), divided by kilograms (weight) or femtograms per milliliter (concentration), divided by grams (weight)." + }, + { + "input": "Concept: total elbow replacement (Arthroplasty of the elbow)", + "output": "Replacement of device described as replacement of the ELBOW JOINT." + }, + { + "input": "Concept: CDISC Questionnaire Terminology (Intellectual Product)", + "output": "Intellectual Product described as the terminology subset that includes terms pertaining to the CDISC questionnaire terminology." + }, + { + "input": "Concept: Neutral (Phenomenon or Process)", + "output": "something described as having no net electric charge; not electrified." + }, + { + "input": "Concept: Aldoketoreductase 7 (Enzyme)", + "output": "Amino Acid, Peptide, or Protein described as aflatoxin B1 aldehyde reductase member 2 (359 aa, ~40 kDa) is encoded by the human AKR7A2 gene. This protein is involved in aldehyde metabolism." + }, + { + "input": "Concept: mitochondrial iron-sulfur cluster assembly complex (Cell Component)", + "output": "Cell Component described as a protein complex consisting of frataxin, cysteine desulfurase, an accessory protein and a Fe-S scaffold protein. In human these genes correspond to FXN, NFS1, ISD11 and ISCU respectively. This complex assembles Fe-S clusters onto the scaffolding protein using the substrates ferrous iron, electrons, and sulfur from l-cysteine." + }, + { + "input": "Concept: upregulation of cytokinesis (positive regulation of cell cycle process)", + "output": "something described as any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells." + }, + { + "input": "Concept: Blood Coagulation Disorder due to Liver Disease (Blood Coagulation Disorders)", + "output": "Blood Coagulation Disorders described as a disorder of blood clotting that is attributable to a deficiency in liver function." + }, + { + "input": "Concept: hypoplastic left heart (Congenital hypoplasia of heart)", + "output": "Other congenital malformations of heart described as a condition caused by underdevelopment of the whole left half of the heart. It is characterized by hypoplasia of the left cardiac chambers (HEART ATRIUM; HEART VENTRICLE), the AORTA, the AORTIC VALVE, and the MITRAL VALVE. Severe symptoms appear in early infancy when DUCTUS ARTERIOSUS closes." + }, + { + "input": "Concept: Pharmaceutic Preparations (Type of drug)", + "output": "Products or substances for personal consumption described as a finished dosage form, for example, tablet, capsule, solution, etc., that contains an active drug ingredient generally, but not necessarily, in association with inactive ingredients. The term also includes a finished dosage form that does not contain an active ingredient but is intended to be used as a placebo." + }, + { + "input": "Concept: L-aspartic acid \u03b2-amide (AMINO ACIDS PORPHYRINS)", + "output": "Amino Acids, Basic described as amino acid with side chain -CH2CONH2." + }, + { + "input": "Concept: (2S)-(((3-Hydroxyadamantan-1-yl)amino)acetyl)pyrrolidine-2-carbonitrile (Pharmacologic Substance)", + "output": "something described as a cyanopyrrolidine-based, orally bioavailable inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Vildagliptin's cyano moiety undergoes hydrolysis and this inactive metabolite is excreted mainly via the urine." + }, + { + "input": "Concept: Guinea, Portuguese (Africa, Western)", + "output": "Africa, Western described as a country in Western Africa, bordering the North Atlantic Ocean, between Guinea and Senegal." + }, + { + "input": "Concept: DLQI1 (Clinical or Research Assessment Questionnaire)", + "output": "Intellectual Product described as a standardized rating scale originally developed by Finlay and Khan in 1994, which is a dermatology-specific health-related quality of life instrument. This questionnaire contains 10 questions concerning symptoms and feelings, daily activities, leisure, work, and school, personal relationships and treatment. Each question can be answered with: very much, a lot, a little or not at all." + }, + { + "input": "Concept: Adnexal Adenocarcinoma, NOS (Adenocarcinoma)", + "output": "Adenocarcinoma described as an adnexal carcinoma with ductal/glandular differentiation lacking specific histological features that would allow further classification." + }, + { + "input": "Concept: Delusions, CTCAE (Finding)", + "output": "Psychiatric Disorders, CTCAE described as a disorder characterized by false personal beliefs held contrary to reality, despite contradictory evidence and common sense." + }, + { + "input": "Concept: Aphidicoline Glycinate (Pharmacologic Substance)", + "output": "DNA Polymerase Inhibitors described as a tetracyclic diterpene antibiotic isolated from the fungus Cephalosporium aphidicola and other fungal species with potential antineoplastic activity. Aphidicoline glycinate blocks the cell cycle at early S-phase by specifically inhibiting DNA polymerases in eukaryotic cells, induces apoptosis, and stops the growth of eukaryotic cells and certain viruses by selectively inhibiting DNA polymerase II or viral-induced DNA polymerases." + }, + { + "input": "Concept: UDP-glucose:glycoprotein glucosyltransferase activity (phenol beta-glucosyltransferase activity)", + "output": "Molecular Function described as catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins." + }, + { + "input": "Concept: Fibromuscular hyperplas artery (Arterial Occlusive Diseases)", + "output": "Disease or Syndrome described as a disorder characterized by fibrous thickening of the arterial wall resulting in narrowing of the arterial lumen. It most often affects the renal artery and less often the carotid artery and abdominal arteries. It can cause hypertension and aneurysm formation." + }, + { + "input": "Concept: Report Nullification (Machine Activity)", + "output": "Action described as action(s) undertaken to indicate that a previously transmitted report should be considered completely void (nullified)." + }, + { + "input": "Concept: Adolescent age (Age)", + "output": "something described as postnatal age 12 to 19." + }, + { + "input": "Concept: High serine levels in cerebrospinal fluid (Finding)", + "output": "Abnormal CSF serine concentration described as abnormally increased levels of serine in cerebrospinal fluid." + }, + { + "input": "Concept: Anatomical lines set (Set of immaterial anatomical entities)", + "output": "Spatial Concept described as non-material physical anatomical entity of one dimension, which forms a boundary of an anatomical surface or is a modulation of an anatomical surface. Examples: margin of tongue, posterior border of right lung, inferior margin of liver, arcuate line of hip bone, sulcus terminalis of heart, pancreatic incisure." + }, + { + "input": "Concept: guanosine (Nucleosides)", + "output": "something described as purine nucleoside that has guanine linked by its N9 nitrogen to the C1 carbon of ribose; a component of ribonucleic acid; its nucleotides play important roles in metabolism." + }, + { + "input": "Concept: FAC07537 (FACT-COG Version 3 Questionnaire Question)", + "output": "FACT-COG Version 3 Questionnaire Question described as functional Assessment of Cancer Therapy-Cognitive Function Version 3 - Impact on Quality of Life: These problems have interfered with the quality of my life." + }, + { + "input": "Concept: DLI (Donor Cellular Infusion)", + "output": "Donor Cellular Infusion described as the infusion of donor lymphocytes following hematopoietic stem cell transplantation for the purpose of augmenting the host immune response or preventing the rejection of the graft." + }, + { + "input": "Concept: polycarbophil/carbomer/glycerin/palm oil glyceride/mineral oil-containing vaginal moisturizer (Pharmacologic Substance)", + "output": "Topical Preparation described as a commercial combination preparation that contains an adhesive polycarbophil polymer, which is used for vaginal lubrication. Polycarbophil is an insoluble compound that absorbs water and, after topical administration, adheres to vaginal epithelial cells. As a result, it helps both moisturize vaginal tissue and relieve the discomfort that is associated with vaginal dryness. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29414\" active clinical trials using this agent." + }, + { + "input": "Concept: Thin fibula (Abnormality of fibula morphology)", + "output": "Finding described as reduced width of the cross sectional diameter of the fibula. []" + }, + { + "input": "Concept: Cosine Distance (Statistical Technique)", + "output": "Quantitative Concept described as a type of pearson measure, which considers the relative differences (e.g. A*B/Abs[A]*Abs[B]) assuming that the scale is uniform (that the distance from zero is relative). In some cases this can give better results, particularly where the data is not 'normally' distributed." + }, + { + "input": "Concept: Abdominal pulse (Organ or Tissue Function)", + "output": "Physiologic pulse described as pulse felt over the abdominal aorta" + }, + { + "input": "Concept: XWNT2 Gene (WNT2B gene)", + "output": "WNT2B gene described as human WNT2B wild-type allele is located in the vicinity of 1p13 and is approximately 56 kb in length. This allele, which encodes protein wnt-2b, plays a role in embryogenesis." + }, + { + "input": "Concept: Small for Gestational Age with Failure of Catch-Up Growth (Finding)", + "output": "Small for gestational age described as a condition in which a child who was born small for gestational age fails to achieve a linear growth rate sufficient to restore height to within the normal range for the reference population." + }, + { + "input": "Concept: ITGB6 Gene (Gene or Genome)", + "output": "Gene or Genome described as this gene plays a role in cell-matrix adhesion." + }, + { + "input": "Concept: Adult Supratentorial Primitive Neuroectodermal Tumor (Neoplastic Process)", + "output": "Supratentorial Embryonal Tumor, Not Otherwise Specified described as a primitive neuroectodermal tumor of the supratentorial area of the brain occurring in adults. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C68703\" active clinical trials using this agent." + }, + { + "input": "Concept: Ethiopian (African race)", + "output": "African race described as denotes the inhabitants of Ethiopia, a person from there, or their descendants elsewhere." + }, + { + "input": "Concept: Smear - instruction imperative (Spreading)", + "output": "Activity described as the action of spreading a thin layer of material across a surface." + }, + { + "input": "Concept: IVD Panels, Human Genetics, Hearing Loss/Deafness, Nonsyndromic (Medical Device)", + "output": "IVD Panels, Human Genetics, Hearing Loss described as molecular assay reagents intended to identify gene variants associated with nonsyndromic hearing loss and deafness, a collection of genetic hearing loss and deafness disorders that are not associated with signs and symptoms affecting other parts of the body. Genetic variants at multiple loci have been associated with nonsyndromic hearing loss and deafness. These reagents are intended to detect various types of genetic changes (e.g., deletions, duplications, insertions, single nucleotide polymorphisms) in multiple nonsyndromic hearing loss and deafness-associated loci simultaneously." + }, + { + "input": "Concept: Obatoclax (Pharmacologic Substance)", + "output": "Organic Chemical described as a small molecule and a pan-inhibitor of Bcl-2 family proteins, with pro-apoptotic activity. GX015-070 is a selective antagonist of the BH3-binding groove of the Bcl-2 family proteins, which are frequently overexpressed in cancers including chronic lymphocytic leukemia (CLL). This agent induces/restores apoptosis in cancer cells by inhibiting apoptosis suppressors in multiple members of the Bcl-2 family simultaneously." + }, + { + "input": "Concept: Nitrofurantoin sodium (nitrofurantoin)", + "output": "Nitrofuran derivative described as a sodium salt form of nitrofurantoin, a synthetic derivative of imidazolidinedione (hydantoin) that inhibits bacterial DNA, RNA, and cell wall protein synthesis." + }, + { + "input": "Concept: IMMUNOGENICITY (Research Activity)", + "output": "something described as a study that assesses an agent's ability to provoke an immune response (humoral and/or cell-mediated) in the subject." + }, + { + "input": "Concept: blood gas transport (Passive biological transport)", + "output": "something described as movement of oxygen from the environment into tissue and elimination of carbon dioxide." + }, + { + "input": "Concept: Product containing moricizine hydrochloride (Phenothiazine and phenothiazine derivative)", + "output": "Sodium Channel Blockers described as the hydrochloride salt form of moricizine, a phenothiazine analog with class I antiarrhythmic activity. Moricizine hydrochloride blocks the rapid flow of sodium ions into the myocardial cell during phase 0 of the action potential. This decreases excitability, slows the impulse conduction through the atrioventricular (AV) node and depresses depolarization." + }, + { + "input": "Concept: SVN53-67/M57-KLH peptide vaccine (Pharmacologic Substance)", + "output": "Vaccines, Peptide described as a peptide vaccine containing a 15-mer peptide (DLAQMFFCFKELEGW), with C to M alteration at amino acid position 57, derived from the anti-apoptosis protein survivin, and conjugated with keyhole limpet hemocyanin (KLH), with potential immunopotentiating and antineoplastic activities. Upon subcutaneous administration of SVN53-67/M57-KLH peptide vaccine, this peptide is able to bind both HMC class I and II molecules and may activate the immune system to mount a cytotoxic T-lymphocyte (CTL) as well as a T-helper cell response against survivin-expressing cancer cells. This may result in decreased tumor cell proliferation and ultimately tumor cell death. Survivin, a member of the inhibitor of apoptosis (IAP) family, expressed during embryonic development while absent in most normal adult cells, is upregulated in a variety of human cancers; its expression in tumors is associated with a more aggressive phenotype, decreased survival, and increased resistance to chemotherapy. KLH may enhance immune recognition and may promote an enhanced response. As SVN53-67 is weakly immunogenic in humans, the M57 alteration may lead to greater affinity towards HLA-A*0201 and thus an enhanced antitumor immune response. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C95705\" active clinical trials using this agent." + }, + { + "input": "Concept: Lethal congenital dwarfism with accelerated skeletal maturation (Osteochondrodysplasias)", + "output": "something described as an autosomal recessive lethal condition caused by inactivating mutation(s) in the PTH1R gene, encoding parathyroid hormone/parathyroid hormone-related peptide receptor. This condition is characterized by short limbs, polyhydramnios, hydrops fetalis, facial anomalies, increased bone density, and advanced skeletal maturation." + }, + { + "input": "Concept: regulation of sev signaling pathway (Molecular Function)", + "output": "regulation of R7 cell differentiation described as any process that modulates the frequency, rate or extent of the sevenless signaling pathway." + }, + { + "input": "Concept: PerformedNotification (Notifications)", + "output": "Notifications described as the completed action within the context of a given study that represents the communication of a message to a recipient. EXAMPLE(S): OTHER NAME(S): NOTE(S):" + }, + { + "input": "Concept: Tumor of Bladder (Lesion of bladder)", + "output": "Mass of urinary bladder described as new abnormal urinary bladder tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease." + }, + { + "input": "Concept: Pulmonary Compliance (Pulmonary function tests)", + "output": "something described as the elasticity of the pulmonary walls." + }, + { + "input": "Concept: Powder for use in drinking water/milk (Biomedical or Dental Material)", + "output": "something described as solid preparation for veterinary use consisting of one or more powders, including freeze-dried powders, intended to be dissolved in the animal drinking water, milk or milk replacer. If alternative methods of administration to individual animals are also authorised, the method of administration is clearly described in the product information." + }, + { + "input": "Concept: alpha-amylase inhibitor activity (Molecular Function)", + "output": "something described as stops, prevents or reduces the activity of alpha-amylase." + }, + { + "input": "Concept: NF-Y Protein (Biologically Active Substance)", + "output": "CCAAT-Enhancer-Binding Proteins described as a heterotrimeric DNA-binding protein that binds to CCAAT motifs in the promoters of eukaryotic genes. It is composed of three subunits: A, B and C." + }, + { + "input": "Concept: lambda Phage (Coliphages)", + "output": "Coliphages described as type species of only officially recognized genus of Siphoviridae." + }, + { + "input": "Concept: Did You Feel Isolated From Others (Intellectual Product)", + "output": "Clinical or Research Assessment Question described as a question about whether an individual does or did feel isolated from others." + }, + { + "input": "Concept: Grade 1 Hypocalcemia (Finding)", + "output": "Finding described as corrected serum calcium of 3)-fucosyltransferase activity." + }, + { + "input": "Concept: FAC07513 (Intellectual Product)", + "output": "something described as functional Assessment of Cancer Therapy-Cognitive Function Version 3 - Perceived Cognitive Impairments: I have forgotten names of people soon after being introduced." + }, + { + "input": "Concept: D-xylose:NAD+ 1-oxidoreductase activity (Molecular Function)", + "output": "something described as catalysis of the reaction: D-xylose + NAD+ = D-xylonolactone + NADH." + }, + { + "input": "Concept: low-density lipoprotein particle receptor binding (lipoprotein particle receptor binding)", + "output": "Molecular Function described as interacting selectively and non-covalently with a low-density lipoprotein receptor." + }, + { + "input": "Concept: Time of Second Temperature (Temporal Concept)", + "output": "Time described as a question about the time that the second body temperature was recorded." + }, + { + "input": "Concept: extrinsic component of presynaptic endosome membrane (Cell Component)", + "output": "Cell Component described as the component of the presynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." + }, + { + "input": "Concept: StudyProtocolVersion.accrualReportingMethodCode (Intellectual Product)", + "output": "something described as a coded value specifying the technique that is used for reporting subject accrual data to the study sponsor." + }, + { + "input": "Concept: Bandage (Biomedical or Dental Material)", + "output": "something described as a solid composed of single or multilayered strips of permeable material." + }, + { + "input": "Concept: Undefined Oriental herb and natural substance letter F narrative required (Classification)", + "output": "something described as any elsewhere undefined Oriental herb and natural substance, letter F, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com." + }, + { + "input": "Concept: Terminating higher education programme (Higher education)", + "output": "something described as leaving higher education in an appropriate manner to enter the next level of school education, work, employment or other domains of adult life." + }, + { + "input": "Concept: Databank, National Practitioner (Intellectual Product)", + "output": "Intellectual Product described as a databank established by the Health Care Quality Improvement Act of 1986 authorizing the Department of Health and Human Services to collect and release information on the professional competence and conduct of physicians, dentists, nurses, and other health care practitioners. The data include adverse actions on physicians' malpractice, licensure, hospital privileges, concealing of pertinent information, and the like." + }, + { + "input": "Concept: Bound (molecular function)", + "output": "something described as the selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." + }, + { + "input": "Concept: Fetoscopies (Endoscopy)", + "output": "Procedure on uterus described as endoscopic examination, therapy or surgery of the fetus and amniotic cavity through abdominal or uterine entry." + }, + { + "input": "Concept: PODCI Adolescent Self-Reported Version - Gym Limited by: Pain (Intellectual Product)", + "output": "Intellectual Product described as pediatric Outcomes Data Collection Instrument, Adolescent Self-Reported Version (PODCI Adolescent Self-Reported Version) If you answered \"sometimes\" or \"never or rarely\" to Question 63 above, was your activity limited by: Pain?" + }, + { + "input": "Concept: NPI - Say, or Act as if He/She is Sad or in Low Spirits (NPI Questionnaire Question)", + "output": "Intellectual Product described as neuropsychiatric Inventory (NPI) Does the patient say, or act as if he/she is sad or in low spirits?" + }, + { + "input": "Concept: Harvest Procedure (Therapeutic or Preventive Procedure)", + "output": "something described as remove from a culture or a living or dead body, as for the purposes of transplantation. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C37963\" active clinical trials using this agent." + }, + { + "input": "Concept: Larotaxel (Organic Chemical)", + "output": "Taxane-Pocket Binding Agent described as a semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic activities. Larotaxel binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. Larotaxel penetrates the blood brain barrier." + }, + { + "input": "Concept: Left Cardiac Ventricular Systolic Dysfunction (Myocardial dysfunction)", + "output": "Left ventricular cardiac dysfunction described as the degree of impairment of the left cardiac ventricle to contract efficiently." + }, + { + "input": "Concept: Mesites maculatus (Galaxias)", + "output": "Fish described as species in the family Galaxiidae, which lives in freshwater streams, but spends some time in the ocean." + }, + { + "input": "Concept: Closed eyeball trauma (Eye injuries NEC)", + "output": "Eye injuries NEC described as traumatic injury to one or more intraocular structures without full thickness wound of the eyewall (sclera and cornea). (adapted from the Birmingham Eye Trauma Terminology System (BETTS))" + }, + { + "input": "Concept: FEMORAL HERNIA (Disorder of inguinal region)", + "output": "External features described as a hernia which occurs just below the inguinal ligament, where abdominal contents pass through a naturally occurring weakness called the femoral canal." + }, + { + "input": "Concept: Doctor's Office (Health care facility)", + "output": "Health Care Related Organization described as a medical facility where a doctor sees and treats patients." + }, + { + "input": "Concept: Unknown Use of Menopausal Hormone Therapy (Finding)", + "output": "something described as a response indicating unknown use of menopausal hormonal therapy." + }, + { + "input": "Concept: Adult-onset distal myopathy due to VCP (valosin containing protein) mutation (Distal Muscular Dystrophies)", + "output": "Distal Muscular Dystrophies described as a rare genetic distal myopathy disorder with characteristics of middle age-onset distal leg muscle weakness, atrophy in the anterior compartment resulting in foot drop without proximal or scapular skeletal muscle weakness. Rapidly progressive dementia, Paget disease of bone and hand weakness has been reported. Muscle biopsy shows pronounced myopathic changes with rimmed vacuoles." + }, + { + "input": "Concept: endocardial cushion cell fate determination (cardiac cell fate determination)", + "output": "cardiac cell fate determination described as the process involved in endocardial cushion cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." + }, + { + "input": "Concept: Gene Product Malfunction Associated With Disease (NCI Thesaurus Role)", + "output": "something described as a role used to indicate that molecular abnormalities in a gene product may be associated with the manifestation of a disease. The role is used to assert a link between a gene product and a disease when the association is considered to have clinical relevance. The domain and range for this role are 'Gene Product' and 'Disease, Disorder or Finding', respectively." + }, + { + "input": "Concept: Bleeding Reduction (Procedure with a clinical finding focus)", + "output": "Therapeutic procedure described as limitation of the loss of blood volume during an episode of bleeding" + }, + { + "input": "Concept: ng*h/mL/kg (Quantitative Concept)", + "output": "something described as hours times nanograms per milliliter (area under the curve), divided by kilograms (weight) or hours times picograms per milliliter (area under the curve), divided by grams (weight)." + }, + { + "input": "Concept: Mild Non-BH4-Deficient Hyperphenylalaninemia (Phenylketonurias)", + "output": "something described as an autosomal recessive condition caused by mutation(s) in the DNAJC12 gene, encoding dnaJ homolog subfamily C member 12. It is characterized by increased serum phenylalanine concentrations resulting in variable neurologic defects, including movement defects and intellectual disability. BH4 metabolism is normal." + }, + { + "input": "Concept: Thymic Atypical Carcinoid Tumor (Thymic Carcinoid Tumor)", + "output": "something described as a primary thymic carcinoid tumor, characterized by a high mitotic rate often associated with the presence of necrosis and nuclear pleomorphism. This type of thymic carcinoid tumor has a more aggressive clinical course, compared to typical thymic carcinoid tumors." + }, + { + "input": "Concept: MSDTC (Collection Date Time)", + "output": "something described as the date and time of the microbiology susceptibility data." + }, + { + "input": "Concept: Cervical canal (Female Reproductive System Part)", + "output": "Structure of lower female genital system described as the neck portion of the UTERUS between the lower isthmus and the VAGINA forming the cervical canal." + }, + { + "input": "Concept: Eudesmanes (Organic Chemical)", + "output": "Polycyclic Sesquiterpenes described as SESQUITERPENES cyclized into two adjoining cyclohexane rings but with a different configuration from the ARTEMISININS." + }, + { + "input": "Concept: Pole of spindle (CYTOPLASMIC FILAMENTS, TUBULES, CENTRIOLES AND ASSOCIATED STRUCTURES)", + "output": "Spindle Apparatus described as either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." + }, + { + "input": "Concept: Ketoacidemias (Measurement finding)", + "output": "Disease or Syndrome described as an increase in the level of ketone bodies in the blood." + }, + { + "input": "Concept: Ischemic Myocardium (Finding)", + "output": "something described as myocardial tissue which exhibits characteristics of inadequate blood flow." + }, + { + "input": "Concept: Stage IIIA Esophageal Adenocarcinoma (Pathologic Stage III Esophageal Adenocarcinoma AJCC v8)", + "output": "Pathologic Stage III Esophageal Adenocarcinoma AJCC v8 described as stage IIIA includes: (T1, N2, M0, Any G); (T2, N1, M0, Any G). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. M0: No distant metastasis." + }, + { + "input": "Concept: FACT-B Version 4 - I Have Pain (FACT-B Version 4 Questionnaire Question)", + "output": "Intellectual Product described as functional Assessment of Cancer Therapy-Breast Version 4 - Physical Well-Being: I have pain." + }, + { + "input": "Concept: Biopsy of Trachea (Respiratory tract evaluation)", + "output": "Diagnostic Procedure described as removal of tissue from the trachea for microscopic examination." + }, + { + "input": "Concept: No known allergy (Finding)", + "output": "Finding with explicit context described as a response indicating that an individual has no known allergies." + }, + { + "input": "Concept: Gamma-Interferon (Pharmacologic Substance)", + "output": "Immunologic Factor described as a recombinant therapeutic agent which is chemically identical to or similar to the endogenous lymphokine interferon gamma (IFN-gamma) with antineoplastic, immunoregulatory, and antiviral activities. Therapeutic IFN-gamma binds to and activates the cell-surface IFN-gamma receptor, stimulating antibody-dependent cytotoxicity and enhances natural killer cell attachment to tumor cells. This agent also activates caspases, thereby inducing apoptosis in malignant cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C583\" active clinical trials using this agent." + }, + { + "input": "Concept: IVD Panels, Human Genetics, Bone Disorder, Skeletal Dysplasia, Comprehensive, Del/Dup (IVD Panels, Human Genetics, Bone Disorder, Skeletal Dysplasia)", + "output": "IVD Panels, Human Genetics, Bone Disorder, Skeletal Dysplasia described as molecular assay reagents intended to identify duplications and deletions of the majority of genes known to be associated with skeletal dysplasias, a collection of conditions affecting bone and cartilage growth. Genetic variants at multiple loci have been associated with various forms of skeletal dysplasia. These reagents are intended to detect deletions and duplications in multiple skeletal dysplasia-associated loci simultaneously." + }, + { + "input": "Concept: Usher Syndrome 1G (Autosomal Recessive) wt Allele (USH1G gene)", + "output": "something described as human USH1G wild-type allele is located in the vicinity of 17q25.1 and is approximately 7 kb in length. This allele, which encodes Usher syndrome type-1G protein, is involved in the development of both the retina and cochlear hair cells. Mutation of the gene is associated with Usher syndrome 1G." + }, + { + "input": "Concept: Bariatric Medicine (Medicine)", + "output": "something described as the discipline concerned with WEIGHT REDUCTION in patients with OBESITY." + }, + { + "input": "Concept: Bladder Cancer cM1 TNM Finding v8 (Bladder Cancer Clinical Distant Metastasis TNM Finding v8)", + "output": "Bladder Cancer Clinical Distant Metastasis TNM Finding v8 described as bladder cancer with distant metastasis." + }, + { + "input": "Concept: polyphosphate breakdown (cellular catabolic process)", + "output": "cellular catabolic process described as the chemical reactions and pathways resulting in the breakdown of a polyphosphate, the anion or salt of polyphosphoric acid." + }, + { + "input": "Concept: 19: 56026591-56020357 (Chromosome 19 Physical Location)", + "output": "something described as physical location of KLK15_Gene" + }, + { + "input": "Concept: Pseudoephedrine Measurement (CNS Stimulant Drug Measurement)", + "output": "something described as the determination of the amount of pseudoephedrine present in a sample" + }, + { + "input": "Concept: PORTAL HYPERTENSION (Liver)", + "output": "Portal Hypertension described as increased blood pressure in the portal venous system. It is most commonly caused by cirrhosis. Other causes include portal vein thrombosis, Budd-Chiari syndrome, and right heart failure. Complications include ascites, esophageal varices, encephalopathy, and splenomegaly." + }, + { + "input": "Concept: PANSS - Poor Attention (Intellectual Product)", + "output": "something described as positive and Negative Syndrome Scale - Poor attention." + }, + { + "input": "Concept: Personalized LADD (Attenuated Bacteria Vaccine)", + "output": "something described as a proprietary, personalized live, attenuated, double-deleted (pLADD) strain of the Gram-positive bacterium Listeria monocytogenes encoding multiple, patient-specific neoantigens, with potential immunostimulatory and antineoplastic activities. Upon intravenous administration, the tumor-associated antigens (TAAs) expressed in pLADD are taken up by antigen-presenting cells (APCs), including dendritic cells (DCs), and are processed and presented to the immune system by both major histocompatibility complex (MHC) class I and II molecules. This activates the immune system and leads to both an innate immune response and the recruitment and activation of tumor-specific cytotoxic T-lymphocytes (CTLs) against the TAAs specifically expressed by the patient's tumor cells, which eventually results in tumor cell lysis." + }, + { + "input": "Concept: Hyperostosis corticalis generalisata (Exostoses)", + "output": "Endosteal hyperostoses described as an autosomal recessive form of craniotubular hyperostosis due to a 52-kb deletion in the SOST gene, encoding sclerostin. Clinical features include normal stature, enlarged jaw and facial bones, hearing loss, and facial palsy due to cranial nerve deficits. The absence of syndactyly distinguishes this condition from sclerosteosis." + }, + { + "input": "Concept: Device, Female Contraceptive (Contraceptive Devices)", + "output": "Contraceptive Devices described as contraceptive devices used by females." + }, + { + "input": "Concept: ApoL Protein (Amino Acid, Peptide, or Protein)", + "output": "Apolipoproteins L described as an ApoL protein highly expressed by the liver. It has anti-trypanosomal activity through its ability to permeabilize TRYPANOSOMA membranes. Mutations in the APOL1 gene are associated with type 4 FOCAL SEGMENTAL GLOMERULOSCLEROSIS ." + }, + { + "input": "Concept: Deficiency of interleukin-1 receptor antagonist (Hereditary disorder of the integument)", + "output": "Disease or Syndrome described as a rare severe genetic autoinflammatory syndrome characterized by usually neonatal onset of generalized neutrophilic cutaneous pustulosis and severe recurrent multifocal aseptic osteomyelitis with marked periostitis, typically affecting distal ribs, long bones and vertebral bodies. High levels of acute-phase reactants (with no fever associated) and onychosis are frequently observed additional features. Caused by homozygous mutation in the IL1RN gene on chromosome 2q14." + }, + { + "input": "Concept: Diagnostic Spirometers (Pulmonary function analyser/analysis system)", + "output": "Pulmonary function analyser/analysis system described as spirometers designed to perform all respiratory gas volume and flow measurements needed for diagnosis of basic pulmonary functions. These instruments measure quiet breathing, determining tidal volume, and trace deep inspirations, evaluating variables such as the maximum volume of gas that can be expired from the lungs (i.e., expiratory vital capacity [EVC]) and the maximum volume of gas that can be inspired into the lungs (i.e., inspiratory vital capacity [IVC]). The IVC test may be performed under static conditions (e.g., to determine the vital capacity) or as a dynamic test using maximum effort against time (e.g., to determine forced expiratory volume [FEV]). Diagnostic spirometers consist of a mechanical or electromechanical device with a computerized unit to process the data, volume and/or flow sensors, a display, and a graph recorder. Some instruments can also determine other parameters, such as oxygen intake and carbon dioxide expiration, either for both lungs simultaneously or for each one independently. These spirometers are intended to assess pulmonary status, to monitor diseases, and/or to evaluate treatment effectiveness and/or disability; they cannot determine lung volume, residual pulmonary, or total lung capacity. Instruments combining spirometry and pulse oximetry capabilities are also available." + }, + { + "input": "Concept: Undefined Western herb and natural substance letter T narrative required (Plant)", + "output": "something described as any elsewhere undefined Western herb and natural substance, letter T, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com." + }, + { + "input": "Concept: Encephalomyelitides, Venezuelan Equine (Other arthropod-borne viral diseases)", + "output": "Encephalomyelitis, Equine described as a form of arboviral encephalitis endemic to Central America and the northern latitudes of South America. The causative organism (ENCEPHALITIS VIRUS, VENEZUELAN EQUINE) is transmitted to humans and horses via the bite of several mosquito species. Human viral infection may be asymptomatic or remain restricted to a mild influenza-like illness. Encephalitis, usually not severe, occurs in a small percentage of cases and may rarely feature SEIZURES and COMA." + }, + { + "input": "Concept: Dentinogeneses (Odontogenesis)", + "output": "Histogenic Process described as the process whose specific outcome is the formation of dentin, the mineralized tissue that constitutes the major bulk of teeth. Dentin may be one of three types: primary dentin, secondary dentin, and tertiary dentin." + }, + { + "input": "Concept: MATEST (CDISC SEND Terminology)", + "output": "something described as terminology for the test names concerned with the findings from a specimen that are visible to the naked eye." + }, + { + "input": "Concept: Axillary abscess (Disorder of axilla)", + "output": "Abscess described as a collection of pus that has formed in the axilla." + }, + { + "input": "Concept: ADNI AVLT - List A Intrusions 4 (ADNI-AVLT Questionnaire Question)", + "output": "ADNI-AVLT Questionnaire Question described as alzheimer's Disease Neuroimaging Initiative Auditory Verbal Learning Test Version A (ADNI-AVLT Version A) The number of intrusions while recalling List A, fourth attempt." + }, + { + "input": "Concept: Gallbladder Cancer cM1 TNM Finding v7 (Gallbladder Cancer Clinical Distant Metastasis TNM Finding v7)", + "output": "Gallbladder Cancer Clinical Distant Metastasis TNM Finding v7 described as gallbladder cancer with distant metastasis." + }, + { + "input": "Concept: CPCJ (CYP2C19 gene)", + "output": "Gene or Genome described as human CYP2C19 wild-type allele is located within 10q24.1-q24.3 and is approximately 90 kb in length. This allele, which encodes cytochrome P450 2C19 protein, is involved in the metabolism of drugs and xenobiotics. Several allelic variants of the CYP2C19 gene contribute to the poor metabolizer phenotype. Conversely, other allelic variants of this gene contribute to the rapid metabolizer phenotype." + }, + { + "input": "Concept: Lead Site aVL-Axial (Electrocardiograph Lead Placement Location)", + "output": "something described as an augmented unipolar electrocardiogram limb lead in which the positive electrode is near the apex of the heart (located in the ICS of left 5-6 rib close to the sternum) and the negative electrode is a combination of the electrode behind the right ear near the right mastoid process and the electrode on hindquarters proximal to the sacrum." + }, + { + "input": "Concept: negative regulation of cellular amine metabolic process (negative regulation of cellular metabolic process)", + "output": "Organism Function described as any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving amines." + }, + { + "input": "Concept: 5-chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)-1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide (R [Preparations])", + "output": "Thiophenes described as an orally bioavailable oxazolidinone derivative and direct inhibitor of the coagulation factor Xa with anticoagulant activity. Upon oral administration, rivaroxaban selectively binds to both free factor Xa and factor Xa bound in the prothrombinase complex. This interferes with the conversion of prothrombin (factor II) to thrombin and eventually prevents the formation of cross-linked fibrin clots. Rivaroxaban does not affect existing thrombin levels." + }, + { + "input": "Concept: ABITUZUMAB (Immunologic Factor)", + "output": "Amino Acid, Peptide, or Protein described as a humanized monoclonal antibody directed against the human alpha v integrin subunit with potential antiangiogenic and antineoplastic activities. Abituzumab, a chimeric antibody which includes the antigen binding sites of the anti-integrin mouse antibody 17E6, binds to and inhibits the activity of alphaVbeta3 integrin (vitronectin receptor); this may result in the inhibition of endothelial cell-cell interactions, endothelial cell-matrix interactions, and integrin-mediated tumor angiogenesis and metastasis in alphavbeta3-expressing tumor cells. AlphaVbeta3 integrin, a cell adhesion and signaling receptor, is expressed on the surface of tumor vessel endothelial cells and plays a crucial role in endothelial cell adhesion and migration." + }, + { + "input": "Concept: 1,4-alpha-D-glucan 6-alpha-D-glucosyltransferase activity (Molecular Function)", + "output": "something described as catalysis of the transfer an alpha-D-glucosyl residue in a (1->4)-alpha-D-glucan to the primary hydroxy group of glucose, free or combined in a (1->4)-alpha-D-glucan." + }, + { + "input": "Concept: Angelica atropurpurea / American angelica (Western herbs and natural substances letter A)", + "output": "Western herbs and natural substances letter A described as american angelica." + }, + { + "input": "Concept: CEREBRAL HEMORRHAGE (Physical & Psychosomatic Disorders)", + "output": "Central Nervous System described as hemorrhage into the parenchyma of the brain." + }, + { + "input": "Concept: convolutionKernel (Intellectual Product)", + "output": "something described as an algorithm used to reconstruct imaging data. Convolution kernels can be used to filter images to smooth them and reduce noise or to enhance edges or other image features." + }, + { + "input": "Concept: up-regulation of apolipoprotein A-I-mediated signalling pathway (positive regulation of signal transduction)", + "output": "Molecular Function described as any process that activates or increases the frequency, rate or extent of apolipoprotein A-I-mediated signaling pathway." + }, + { + "input": "Concept: Firm enough for masturbation and foreplay only (Intellectual Product)", + "output": "something described as a response about an individual's erections being firm enough for masturbation and foreplay only." + }, + { + "input": "Concept: Forced Choice Testing Method (Testing Methods)", + "output": "Test Method described as assessment method requiring a choice between equally unlikely or undesirable alternatives, designed to reduce the effects of social desirability on the selection of test answers." + }, + { + "input": "Concept: 2-butanone metabolism (cellular ketone metabolic process)", + "output": "Xenobiotic Metabolism described as the chemical reactions and pathways involving methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor. It is used as a solvent and in making plastics, textiles and paints." + }, + { + "input": "Concept: Dentin Bonding Agents (Biomedical or Dental Material)", + "output": "Dental Materials described as cements that act through infiltration and polymerization within the dentinal matrix and are used for dental restoration. They can be adhesive resins themselves, adhesion-promoting monomers, or polymerization initiators that act in concert with other agents to form a dentin-bonding system." + }, + { + "input": "Concept: CSS09-Idea, No Intent, No Plan, Describe (Intellectual Product)", + "output": "something described as columbia-Suicidality Severity Rating Scale Screening (C-SSRS Screening) Description of active suicidal ideation with any methods (not plan) without intent to act." + }, + { + "input": "Concept: IDSR109B (Intellectual Product)", + "output": "IDS-SR Questionnaire Question described as inventory of Depressive Symptomatology Self-Report Version (IDS-SR) Is your mood variation attributed to the environment?" + }, + { + "input": "Concept: Tumor CMR (Radiologic finding)", + "output": "something described as a finding of disappearance of metabolic tumor activity in target and non-target lesions, marked by a decrease in tumor standardized uptake value to the level of surrounding normal tissue." + }, + { + "input": "Concept: SELP (Gene or Genome)", + "output": "something described as this gene plays a role in cellular adhesion and mediates immune and endothelial cell interactions." + }, + { + "input": "Concept: RACMAX (Pharmaceutical Product Characteristics)", + "output": "Laboratory Procedure described as the determination of the ratio of one Cmax value compared to another Cmax value. The measurement may be expressed as a ratio or percentage." + }, + { + "input": "Concept: Blotchy loss of skin color (Hypopigmentation disorder)", + "output": "Pigmentation Disorders described as generalized well circumscribed patches of leukoderma that is generally distributed over symmetric body locations and is due to autoimmune destruction of melanocytes." + }, + { + "input": "Concept: From Time to Time (Frequencies)", + "output": "something described as not frequently or regularly." + }, + { + "input": "Concept: Dense skull cap (Abnormality of the calvaria)", + "output": "something described as an abnormal increase of density of the bones making up the calvaria." + }, + { + "input": "Concept: NWTS EE-4A Regimen (Chemotherapy Regimen Used to Treat Childhood Malignant Renal Neoplasm)", + "output": "Therapeutic or Preventive Procedure described as a regimen consisting of vincristine and dactinomycin, administered after nephrectomy and used for the treatment of limited-stage Wilm's tumor with a favorable histology, including focal anaplastic disease." + }, + { + "input": "Concept: PULMONARY ARTERIES (Artery of trunk)", + "output": "root described as one of the arteries of the thorax; in general it arises from the pulmonary trunk and branches into the lungs." + }, + { + "input": "Concept: Procedure End Relative to Reference Time Point (Temporal Concept)", + "output": "Temporal Concept described as an indication or description that the end of the procedure is before, during or after a reference moment in time." + }, + { + "input": "Concept: NCI CTEP Simple Disease Classification AIDS-related Human Papillomavirus Sub-Category Terminology (Intellectual Product)", + "output": "something described as AIDS-related Human Papillomavirus is an NCI Cancer Therapeutic Evaluation Program (CTEP) Simplified Disease Classification (SDC) category used to organize cancer-related disease coding that harmonizes with and supports reporting based on the global standard Medical Dictionary for Drug Regulatory Reporting (MedDRA) terminology." + }, + { + "input": "Concept: recombinant thymosin (Therapeutic Hormone)", + "output": "Hormone described as a recombinant form of a polypeptide chemically identical to or similar to the hormone secreted by the thymus gland. Thymosin is generally known to have functions in the preprocessing of T cells and the development of B cells to plasma cells to produce antibodies. In particular, the predominant form of thymosin, beta 4 thymosin, is the principal actin-sequestering protein that plays an important role in functions that involve actin molecules, such as maintenance of cell shape, cytoplasmic organization, cell movement, and cell division. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C883\" active clinical trials using this agent." + }, + { + "input": "Concept: Weight gain (Investigations, CTCAE)", + "output": "Investigations, CTCAE described as a finding characterized by an unexpected or abnormal increase in overall body weight; for pediatrics, greater than the baseline growth curve." + }, + { + "input": "Concept: Esophagus dilated (Disease or Syndrome)", + "output": "Esophageal Diseases described as an abnormal dilation of the esophagus not due to obstruction." + }, + { + "input": "Concept: Erbb2-Interacting Protein (Biologically Active Substance)", + "output": "something described as protein LAP2 (1412 aa, ~158 kDa) is encoded by the human ERBIN gene. This protein plays a role in the modulation of receptor tyrosine kinase signaling." + }, + { + "input": "Concept: Grade 1 Mucosal infection (Mucosal Infection, CTCAE)", + "output": "something described as localized, local intervention indicated" + }, + { + "input": "Concept: kali chlorosum/javelle H2O/b (Homeopathic remedies letter K)", + "output": "Homeopathic remedies letter K described as javelle water, bleaching fluid." + }, + { + "input": "Concept: Eph receptor binding (signaling receptor binding)", + "output": "something described as interacting selectively and non-covalently with an ephrin receptor." + }, + { + "input": "Concept: Quetiapina (Organic Chemical)", + "output": "Allergen class described as a dibenzothiazepine derivative with antipsychotic property. Quetiapine fumarate antagonizes serotonin activity mediated by 5-HT 1A and 5-HT2 receptors. With a lower affinity, this agent also reversibly binds to dopamine D1 and D2 receptors in the mesolimbic and mesocortical areas of the brain leading to decreased psychotic effects, such as hallucinations and delusions. In addition, quetiapine also binds to other alpha-1, alpha-2 adrenergic and histamine H1 receptors." + }, + { + "input": "Concept: Openmindedness (Personality Traits)", + "output": "something described as willingness to consider new and unconventional ideas, and readiness to reexamine social, political, and religious values." + }, + { + "input": "Concept: program full description (Description)", + "output": "Intellectual Product described as an unabridged description of a research program or study." + }, + { + "input": "Concept: thymidine diphospho-6-deoxy-L-talose dehydrogenase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)", + "output": "something described as catalysis of the reaction: dTDP-6-deoxy-L-talose + NADP(+) = dTDP-4-dehydro-6-deoxy-L-mannose + H(+) + NADPH." + }, + { + "input": "Concept: fatigue chronic (Fatigue)", + "output": "Effect of substance addiction described as subjective feeling of tiredness characterized by a lack of energy and motivation that persists for six months or longer." + }, + { + "input": "Concept: satellite cell compartment self-renewal involved in skeletal muscle regeneration (Cell Function)", + "output": "something described as any process by which the number of skeletal muscle satellite cells in a skeletal muscle is maintained during muscle regeneration. There are at least three mechanisms by which this is achieved. Skeletal muscle satellite stem cell asymmetric division ensures satellite stem cell numbers are kept constant. Symmetric division of these cells amplifies the number of skeletal muscle satellite stem cells. Some adult skeletal muscle myoblasts (descendants of activated satellite cells) can develop back into quiescent satellite cells, replenishing the overall pool of satellite cells." + }, + { + "input": "Concept: Thai (Population Group)", + "output": "Mongol Chinese described as denotes the inhabitants of Thailand, a person from there, or their descendants elsewhere." + }, + { + "input": "Concept: Flt-3-targeting Agent (Organic Chemical)", + "output": "something described as any agent that targets Flt-3 (Flt3)." + }, + { + "input": "Concept: Fourth degree burn of finger (Soft Tissue Injuries)", + "output": "Injury or Poisoning described as burn involving skin, subcutaneous tissues, and underlying structures of finger." + }, + { + "input": "Concept: OAB-q Questionnaire Question (Intellectual Product)", + "output": "Intellectual Product described as a question associated with the OAB-q questionnaire." + }, + { + "input": "Concept: Corsican Language (Language)", + "output": "Romance language described as a Romance language within the Italo-Dalmatian subfamily spoken mainly in Corsica and northern Sardinia." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Cytology/Histology, Stain (Medical Device)", + "output": "Medical Device described as reagents used for artificial coloration of the constituent parts of the cells and the intercellular material. They usually consist of natural or artificial dyes. Most cytology and histology stains are used for visual or microscopic differentiation between parts of the cell (e.g., nucleus, cytoplasm) and/or to differentiate between the different types of cells and tissues." + }, + { + "input": "Concept: Dipeptidyl peptidase I (Enzyme)", + "output": "Cathepsins described as a papain-like cysteine protease that has specificity for amino terminal dipeptides. The enzyme plays a role in the activation of several pro-inflammatory serine proteases by removal of their aminoterminal inhibitory dipeptides. Genetic mutations that cause loss of cathepsin C activity in humans are associated with PAPILLON-LEFEVRE DISEASE." + }, + { + "input": "Concept: Microfilaria, NOS (Filaroididae)", + "output": "Filaroididae described as the prelarval stage of Filarioidea found in the blood and tissues of mammals, birds and intermediate hosts (vector)." + }, + { + "input": "Concept: alphaV-beta3 integrin-laminin alpha-4 complex (Cell Component)", + "output": "Cell Component described as a protein complex that consists of an alphaV-beta3 integrin complex bound to laminin alpha-4." + }, + { + "input": "Concept: OSTEOARTHRITIS OF HIP (Degenerative joint disease of pelvis)", + "output": "Hip joint finding described as noninflammatory degenerative disease of the hip joint which usually appears in late middle or old age. It is characterized by growth or maturational disturbances in the femoral neck and head, as well as acetabular dysplasia. A dominant symptom is pain on weight-bearing or motion." + }, + { + "input": "Concept: CF1 (Mice, Inbred Strains)", + "output": "Mice, Inbred Strains described as thought to be wild albino in origin, this strain was obtained by Carworth farms from a Missouri laboratory. It was intensely inbred by N. Goto in 1978 from a single Carworth pair, the progeny of which is used today. The CF-1 mouse has an albino coat with genotype c and is used as a multi-purpose strain for a variety of applications including infectious disease modeling, embryological studies, and safety and efficacy testing. In this mouse model, cleft palate formation can be induced by cortisone while alloxan treatment induces diabetes in a high percentage of CF-1 mice." + }, + { + "input": "Concept: Ribosomal Subunit, Small (Ribosome Subunits)", + "output": "Ribosome Subunits described as the small ribonucleoprotein component of RIBOSOMES. It contains the MESSENGER RNA binding site and two TRANSFER RNA binding sites - one for the incoming AMINO ACYL TRNA (A site) and the other (P site) for the peptidyl tRNA carrying the elongating peptide chain." + }, + { + "input": "Concept: Tetrazolium Salts (Tetrazoles)", + "output": "Indicator, Reagent, or Diagnostic Aid described as quaternary salts derived from tetrazoles. They are used in tests to distinguish between reducing sugars and simple aldehydes, for detection of dehydrogenase in tissues, cells, and bacteria, for determination of corticosteroids, and in color photography." + }, + { + "input": "Concept: Melanoma of the Conjunctiva cM1 TNM Finding v7 (Melanoma of the Conjunctiva Clinical Distant Metastasis TNM Finding v7)", + "output": "Melanoma of the Conjunctiva Clinical Distant Metastasis TNM Finding v7 described as melanoma of the conjunctiva with distant metastasis." + }, + { + "input": "Concept: Langerhans cell histiocytosis, poly-ostotic (Neoplastic Process)", + "output": "something described as langerhans cell histiocytosis presenting with multiple sites of involvement." + }, + { + "input": "Concept: Warm reactive autoantibody positivity (Autoimmune antibody positivity)", + "output": "something described as warm reactive autoantibodies are RBC-directed immune responses that are maximally reactive at 37 degrees C." + }, + { + "input": "Concept: mesaconate hydratase activity (Molecular Function)", + "output": "hydro-lyase activity described as catalysis of the reaction: S-citramalate = H(2)O + mesaconate." + }, + { + "input": "Concept: Boils (Soft tissue lesion)", + "output": "Sycosis described as an infection of a hair follicle that extends subcutaneously, forming an abscess. []" + }, + { + "input": "Concept: Pseudomonas caviae (Bacterium)", + "output": "Bacterium described as a species of gram-negative, facultatively anaerobic bacteria that is found in domestic and wild animals including birds, and fish. In humans it causes GASTROENTERITIS in young children and some adults." + }, + { + "input": "Concept: Colour blindness, NOS (Eye)", + "output": "Disorder of refraction AND/OR accommodation described as impaired ability to distinguish colors on the spectrum." + }, + { + "input": "Concept: GUERNSEY (Country)", + "output": "Geographic Area described as the second largest of the Channel Islands in the English Channel. It covers about 30 square miles and is where the Guernsey breed of cattle originated. The name is Scandinavian, Grani's island (ey means island)." + }, + { + "input": "Concept: Every Three Years (Intervals of years)", + "output": "Temporal Concept described as planned or occurring every three years." + }, + { + "input": "Concept: tetralogy of fallot with pulmonary stenosis (Congenital Abnormality)", + "output": "Tetralogy of Fallot described as the commonest form of tetralogy of Fallot characterized by pulmonary stenosis, overriding aorta, ventricular septum defect, and right ventricular hypertrophy, without pulmonary atresia, absent pulmonary valve, atrioventricular canal defect or absent subarterial conus." + }, + { + "input": "Concept: PDPK1 (Gene or Genome)", + "output": "Serine/Threonine Protein Kinase Gene described as this gene plays a role in cellular signaling and development." + }, + { + "input": "Concept: 5th (Quantitative Concept)", + "output": "General adjectival modifier described as following the fourth position in an ordering or series; coming next after the fourth and just before the sixth in position." + }, + { + "input": "Concept: methylseleninic acid reductase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the reaction: NADPH + H+ + CH3SeO2H => NADP+ + CH3SeOH + H2O." + }, + { + "input": "Concept: Mirtazapine (Pharmaceutical Preparations)", + "output": "something described as a synthetic tetracyclic derivative of the piperazino-azepines with antidepressant activity. Although its mechanism of action is unknown, mirtazapine enhances central adrenergic and serotonergic transmission, possibly by acting as an antagonist at central presynaptic alpha 2 adrenergic inhibitory autoreceptors and heteroreceptors. This agent is a potent antagonist of 5-hydroxytryptamine type 2 (5-HT2), 5-HT3, and histamine 1 (H1) receptors, and a moderate antagonist of peripheral alpha 1 adrenergic and muscarinic receptors." + }, + { + "input": "Concept: TUG Functional Test Question (Intellectual Product)", + "output": "Intellectual Product described as a question associated with the TUG functional test." + }, + { + "input": "Concept: Calcium Cation (C [Preparations])", + "output": "calcium described as calcium ion requiring two electrons to return to its elemental state." + }, + { + "input": "Concept: HUNTINGTON-LIKE NEURODEGENERATIVE DISORDER 1 (Hereditary disorder of nervous system)", + "output": "Huntington Disease-Like Syndrome described as a rare genetic human prion disease characterized by adult-onset neurodegenerative manifestations associated with a movement disorder and psychiatric/behavioral disturbances. Patients typically present personality changes, aggressiveness, manias, anxiety and/or depression in conjunction with rapidly progressive cognitive decline (presenting with dysarthria, apraxia, aphasia and eventually leading to dementia) as well as ataxia (manifesting with gait disturbances, unsteadiness, coordination problems), Parkinsonism, myoclonus, and/or chorea. Additional features may include generalized spasticity, seizures, urine incontinence and pyramidal abnormalities. There is evidence the disease is caused by 8 extra octapeptide repeats in the PRNP gene on chromosome 20p13." + }, + { + "input": "Concept: Neoplasm of the Respiratory Tract (Respiratory Tract Diseases)", + "output": "Abnormality of the respiratory system described as a tumor (abnormal growth of tissue) of the respiratory system." + }, + { + "input": "Concept: SOP (Conceptual Entity)", + "output": "Means described as written instructions for doing a specific task in a certain way. In clinical trials, SOPs are set up to store records, collect data, screen and enroll subjects, and submit Institutional Review Board (IRB) applications and renewals." + }, + { + "input": "Concept: Pleural effusion (Finding)", + "output": "Respiratory, Thoracic and Mediastinal Disorders, CTCAE described as a disorder characterized by an increase in amounts of fluid within the pleural cavity. Symptoms include shortness of breath, cough and marked chest discomfort." + }, + { + "input": "Concept: gstroint.ntrl tube nsrxn ea. (Therapeutic or Preventive Procedure)", + "output": "something described as inserting a percutaneous enteral feeding tube into a client/patient's gastrointestinal tract. Service is billed per placement." + }, + { + "input": "Concept: Defined Activity Name Code (Name Code)", + "output": "something described as a coded value specifying the non-unique textual identifier for the activity." + }, + { + "input": "Concept: SDTM-FATESTCD (Intellectual Product)", + "output": "Unused Subset Concept described as terminology associated with the findings about test code codelist of the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: erythrocytosis (Red blood cell count raised)", + "output": "Red blood cell count raised described as an abnormal increase of the red blood cell in the circulating blood" + }, + { + "input": "Concept: GHR Antisense Oligonucleotide IONIS-GHR-LRx (Nucleic Acid, Nucleoside, or Nucleotide)", + "output": "Nucleic Acid, Nucleoside, or Nucleotide described as an antisense oligonucleotide targeting the growth hormone receptor (GHR; somatotropin receptor) mRNA, with potential somatotropin-inhibiting activity. Upon subcutaneous administration, GHR antisense oligonucleotide IONIS-GHR-LRx hybridizes with GHR mRNA, which blocks translation of the GHR protein. Reduction of GHR levels in turn decreases the circulating level of insulin-like growth factor-1 (IGF-1). IGF-1 is a hormone that plays an important role in childhood growth and has anabolic effects in adults. Excess production of IGF-1 results in various disease states including acromegaly." + }, + { + "input": "Concept: Reprocessed Code (Intellectual Product)", + "output": "Code described as a coded value specifying whether a product is reconditioned." + }, + { + "input": "Concept: acetylcholine receptor signalling, muscarinic pathway (acetylcholine receptor signaling pathway)", + "output": "GPCR Signaling Pathway described as any series of molecular signals initiated by an acetylcholine receptor on the surface of the target cell binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription." + }, + { + "input": "Concept: Peripheral T-cell Lymphoma Prognostic Index Score (Intellectual Product)", + "output": "Research or Clinical Assessment Tool described as a list of four factors to assess how an individual with peripheral T-cell lymphoma might respond to treatment and predict the risk of disease recurrence. The factors are: patient's age, LDH levels: serum levels often correlate with the amount of tumor in the body, performance status, and bone marrow involvement." + }, + { + "input": "Concept: larval behavior (Individual Behavior)", + "output": "something described as behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics." + }, + { + "input": "Concept: Fatigue Interference Score 10 (Intellectual Product)", + "output": "Intellectual Product described as a subjective score of 10 on a fatigue scale that ranges from 0: Does Not Interfere to 10: Completely Interferes." + }, + { + "input": "Concept: IRoG (Body Part, Organ, or Organ Component)", + "output": "frontal lobe described as a convolution on the medial surface of the frontal lobe in the human ( Mai-1997 ). Defined on the basis of dissection and stains for Nissl substance, it is bounded dorsally by the superior rostral gyrus and the cingulate gyrus. Ventrally the rostral sulcus separates it from the straight gyrus. It is not found in the macaque, where the comparable area dorsal to the rostral sulcus is occupied by the anterior cingulate gyrus ( Martin-2000 ). Equivalent structures are not found in the smooth cerebral cortex of the rat or mouse ( NeuroNames )." + }, + { + "input": "Concept: Grade 1 Bladder spasms (Finding)", + "output": "Finding described as intervention not indicated" + }, + { + "input": "Concept: Left atrium systolic volume (Clinical Attribute)", + "output": "Clinical Attribute described as volume of blood contained in the left atrium at end-systole." + }, + { + "input": "Concept: structure tendon (Tendon and/or tendon sheath structure)", + "output": "Skeletal muscle structure described as tough, fibrous, cord-like tissue that connects muscle to bone or another structure, such as an eyeball. Tendons help the bone or structure to move." + }, + { + "input": "Concept: Patient Communication/Entertainment Systems (Hospital Communication Systems)", + "output": "Manufactured Object described as hospital communication systems designed to provide entertainment for patients and to provide two-way communication between healthcare personnel and patients during medical procedures, such as magnetic resonance imaging. They are intended to help patients become more comfortable by providing a distraction in order to reduce anxiety and claustrophobia during medical procedures. These systems are usually comprised of video and audio capabilities, such as video, television, and radio input, and adjustable, integrated audio-video headset with volume adjustments that can be controlled by the patient and by healthcare personnel. Hospital communication/entertainment systems that can provide access to on-demand entertainment, educational programming, web content, and e-mail, are also available." + }, + { + "input": "Concept: ES (Affiliate Realms)", + "output": "Country described as a country in southwestern Europe, bordering the Bay of Biscay, Mediterranean Sea, and North Atlantic Ocean, southwest of France." + }, + { + "input": "Concept: Stage IVB Colorectal Carcinoma AJCC v8 (Neoplastic Process)", + "output": "Stage IV Colorectal Cancer AJCC v8 described as stage IVB includes: Any T, Any N, M1b. M1b: Metastasis to two or more sites or organs without peritoneal metastasis." + }, + { + "input": "Concept: APPLICATOR (LARYNGO-TRACHEAL), TOPICAL ANESTHESIA (Medical Device)", + "output": "something described as a laryngotracheal topical anesthesia applicator is a device used to apply topical anesthetics to a patient's laryngotracheal area." + }, + { + "input": "Concept: piedras (Disease or Syndrome)", + "output": "Mycoses described as either of two diseases resulting from fungal infection of the hair shafts. Black piedra occurs mainly in and on the hairs of the scalp and is caused by Piedraia hortae; white piedra occurs in and on the hairs of the scalp, beard, moustache and genital areas and is caused by Trichosporon species." + }, + { + "input": "Concept: PerformedStudySubjectMilestone (Research Activity)", + "output": "Research Activity described as the completed action which marks a common administrative landmark for a subject in the course of a study. EXAMPLE(S): obtain informed consent, verify eligibility criteria, enroll, registration to a study, randomize, assignment to a treatment arm, start of on-study period, complete study visits, end of on-study period, exit study, break treatment blind, premature withdrawal, assignment to a specimen collection protocol at a collection laboratory OTHER NAME(S): NOTE(S):" + }, + { + "input": "Concept: pentaerythritol tetranitrate metabolism (Molecular Function)", + "output": "something described as the chemical reactions and pathways involving pentaerythritol tetranitrate, C(CH2-O-NO2)4, a substance produced for use as an explosive and a vasodilator." + }, + { + "input": "Concept: Ureterostomy procedure (Exteriorization - action)", + "output": "Operation on urinary system described as a surgically created connection between the ureter and the skin, which drains urine from the ureter in individuals with urinary obstruction or other issues that prevent normal urination." + }, + { + "input": "Concept: negative regulation of mitotic recombination (regulation of mitotic recombination)", + "output": "Cell Function described as any process that inhibits or decreases the rate of DNA recombination during mitosis." + }, + { + "input": "Concept: EPSEVNUM (Number of Episodes)", + "output": "Quantitative Concept described as the number of times an event, which is classified as severe, occurred." + }, + { + "input": "Concept: hTERT Vaccine V934/V935 (Immunologic Factor)", + "output": "Immunologic Factor described as a cancer vaccine directed against human telomerase reverse transcriptase (hTERT), the catalytic subunit of human telomerase, with potential immunostimulating and antineoplastic activities. Upon administration, hTERT vaccine V934/V935 may elicit a cytotoxic T cell (CTL) response against telomerase-expressing tumor cells, which may result in tumor cell death. Telomerase is involved in the restoration and maintenance of telomere length and so the functional lifespan of cells. Abnormally reactivated in tumorigenesis, telomerase is expressed in the majority of human cancer cells but is not expressed or is expressed at very low levels in normal cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C80055\" active clinical trials using this agent." + }, + { + "input": "Concept: Zic family member 3 (Gene or Genome)", + "output": "something described as this gene is involved in transcription and development." + }, + { + "input": "Concept: glycochenodeoxycholate sulfotransferase activity (sulfotransferase activity)", + "output": "something described as catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-diphosphate + glycochenodeoxycholate 7-sulfate + H(+)." + }, + { + "input": "Concept: glycolipid binding (Molecular Function)", + "output": "Molecular Function described as interacting selectively and non-covalently with a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate." + }, + { + "input": "Concept: EMG: repetitive nerve stimulation abnormality (Electromyogram abnormal)", + "output": "Electromyogram abnormal described as abnormality observed upon electromyography when nerve studied is electrically stimulated six to ten times at 2 or 3 Hertz." + }, + { + "input": "Concept: gene silencing by RNA, production of guide RNA (Genetic Function)", + "output": "Genetic Function described as the process in which a double-stranded RNA precursor is processed into short (20-30 nt) fragments. RNA cleavage is catalyzed by a Dicer endonuclease." + }, + { + "input": "Concept: early endosome to recycling endosome transport (Cell Function)", + "output": "Cytoplasmic transport described as the directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the recycling endosomes." + }, + { + "input": "Concept: Anti-Type V Collagen Antibody (Antibodies)", + "output": "something described as any immunoglobulin that recognizes type V collagen." + }, + { + "input": "Concept: Fiat anatomical surface (Anatomical Structure)", + "output": "Anatomical Structure described as anatomical surface which, as an imaginary plane, bisects an anatomical structure or an anatomical space. Examples: craniocervical plane, plane of pelvic inlet, temporal plane." + }, + { + "input": "Concept: corticospinal tracts (Body Part, Organ, or Organ Component)", + "output": "lateral forebrain bundle system described as a fiber pathway from the cerebral cortex to the spinal cord. Its fibers originate from pyramidal neurons of the precentral gyrus, and on their way to the spinal cord, pass through parts of the cerebral white matter (including the posterior limb of the internal capsule), the crus cerebri, the longitudinal pontine fibers, the pyramid of the medulla (where they are known as the pyramidal tract) and the pyramidal decussation. In the ducussation, some fibers cross to the other side of the brainstem to form the lateral corticospinal tract. Those fibers that do not cross split to form the anterolateral corticospinal tract and the anterior corticospinal tract ( Carpenter-1983 ). Some parts of the tract are not readily distinguished in myelin stained cross-sections." + }, + { + "input": "Concept: Fluorescent Agents (Coloring Agents)", + "output": "Indicator, Reagent, or Diagnostic Aid described as dyes that emit light when exposed to light; the wave length of the emitted light is usually longer than that of the incident light; fluorochromes are substances that cause fluorescence in other substances, that is, dyes used to mark or label other compounds with fluorescent tags, and they are used as markers in biochemistry and immunology." + }, + { + "input": "Concept: Exercisers, Flexibility, Lower Limb (Manufactured Object)", + "output": "Flexibility exerciser described as flexibility exercisers designed to improve the range of motion (i.e., flexibility) around a joint by supporting and/or positioning the user, making it possible to stretch the muscles in the lower limbs. These exercisers are usually portable devices with handlebars or stand-alone exercise workstations. Lower-limb flexibility exercisers are intended to improve the flexibility of the muscles in the lower limbs; they can also increase muscle (e.g., quadriceps, gluteus, hamstring, calves) strength and improve balance and stability. Dedicated flexibility exercisers, such as a quadriceps board, and a slant board, are available for stretching the lower limbs." + }, + { + "input": "Concept: HiDAC (Therapeutic or Preventive Procedure)", + "output": "Therapeutic or Preventive Procedure described as a chemotherapy regimen consisting of high-dose cytarabine that may be used in the treatment of acute myeloid leukemia (AML) and primary central nervous system (CNS) lymphoma." + }, + { + "input": "Concept: mexacarbate (Acetylcholinesterase Inhibitors)", + "output": "something described as the carbamate agent mexacarbate." + }, + { + "input": "Concept: arsine (Vesicants)", + "output": "lewisite described as the chemical agent arsine." + }, + { + "input": "Concept: Smoker, Current Status Unknown (Smoking Status)", + "output": "Smoking Status described as indicates a person who is known to have smoked but whose current smoking status is unknown." + }, + { + "input": "Concept: Nervonic acid (tetracosenoic acid)", + "output": "tetracosenoic acid described as a monounsaturated fatty acid with a 24-carbon backbone and the sole double bond originating from the 9th carbon from the methyl end, with this bond in the cis- configuration." + }, + { + "input": "Concept: Grade 1 Laryngeal inflammation (Finding)", + "output": "something described as mild sore throat; raspy voice" + }, + { + "input": "Concept: urethrovaginal; fistula (Urethral fistula)", + "output": "Anatomical Abnormality described as the presence of a fistula between the vagina and the urethra." + }, + { + "input": "Concept: Stage IV Vulvar Cancer AJCC v7 (Neoplastic Process)", + "output": "stage, vulvar cancer described as stage IV includes: IVA: (T1/T2, N3, M0); (T3, Any N, M0); IVB: (Any T, Any N, M1). T1: Invasive vulvar cancer confined to the vulva or perineum. T2: Vulvar cancer with tumor of any size with extension to adjacent perineal structures (lower/distal 1/3 urethra, lower/distal 1/3 vagina, anal involvement). T3: Vulvar cancer with tumor of any size with extension to any of the following: upper/proximal 2/3 urethra, upper/proximal 2/3 vagina, bladder mucosa, rectal mucosa, or fixed to pelvic bone. N3: Vulvar cancer with fixed or ulcerated regional lymph node metastasis. M1: distant metastasis (including pelvic lymph node metastasis). (AJCC 7th ed.) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C89453\" active clinical trials using this agent." + }, + { + "input": "Concept: Models, Nursing (Theoretical model)", + "output": "Intellectual Product described as theoretical models simulating behavior or activities in nursing, including nursing care, management and economics, theory, assessment, research, and education. Some examples of these models include Orem Self-Care Model, Roy Adaptation Model, and Rogers Life Process Model." + }, + { + "input": "Concept: tyrosine catabolic process to fumarate (Molecular Function)", + "output": "tyrosine catabolic process described as the chemical reactions and pathways resulting in the breakdown of tyrosine into other compounds, including fumarate." + }, + { + "input": "Concept: Subgroup III Geminivirus (Virus)", + "output": "Virus described as a genus of plant viruses in the family GEMINIVIRIDAE that are transmitted in nature by whitefly Bemisia tabaci." + }, + { + "input": "Concept: Saxifraga L., 1753 (Saxifragaceae)", + "output": "something described as a plant genus of the family SAXIFRAGACEAE." + }, + { + "input": "Concept: PODCI2-Miss School Because of Health (Intellectual Product)", + "output": "something described as pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported Version (PODCI Adolescent Parent-Reported Version) On average, over the last 12 months, how often did your child miss school (camp, etc.) because of his/her health?" + }, + { + "input": "Concept: Needle track marks (Injury or Poisoning)", + "output": "Traumatic injection site described as visible marks on the skin caused by puncture wounds, most commonly associated with intravenous drug use." + }, + { + "input": "Concept: ChAdOx.5T4 vaccine (Pharmacologic Substance)", + "output": "something described as a cancer vaccine comprised of a recombinant, attenuated, replication-defective simian adenovirus vector (ChAdOx1) encoding the human 5T4 fetal oncoprotein (ChAdOx1.5T4), with potential immuno-activating and antineoplastic activities. Upon administration of the recombinant attenuated chimpanzee adenovirus 5T4 vaccine, the viral vector expresses 5T4 and stimulates the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing 5T4, which results in tumor cell lysis. 5T4, a transmembrane glycoprotein, is overexpressed by a variety of cancer cell types; its expression is correlated with increased invasiveness. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C121544\" active clinical trials using this agent." + }, + { + "input": "Concept: Lymphatic Pump (Therapeutic or Preventive Procedure)", + "output": "something described as a term used to describe the impact of intrathoracic pressure changes on lymphatic flow." + }, + { + "input": "Concept: GIST by AJCC v8 Stage (Soft Tissue Sarcoma by AJCC v8 Stage)", + "output": "something described as a term that refers to the staging of gastrointestinal stromal tumor (GIST), following the rules of the TNM AJCC v8 classification system. This staging system does not apply to pediatric GIST, familial GIST (germline mutant KIT or PDGFRA), or syndromic GIST (no AJCC staging system available)." + }, + { + "input": "Concept: up-regulation of phosphoenolpyruvate kinase activity (Molecular Function)", + "output": "Molecular Function described as any process that activates or increases the frequency, rate or extent of pyruvate kinase activity." + }, + { + "input": "Concept: NADH:Fe3+ oxidoreductase activity (oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor)", + "output": "Molecular Function described as catalysis of the reaction: 2 Fe2+ + NAD+ = 2 Fe3+ + NADH + H(+)." + }, + { + "input": "Concept: ALDOSTERONE ANTAG (natriuretic)", + "output": "Antihypertensive Agents described as agent that counteracts or opposes the action of aldosterone." + }, + { + "input": "Concept: How has having gynecologic cancer affected your sexual satisfaction when you have sex (Intellectual Product)", + "output": "something described as a question about how having gynecologic cancer has affected an individual's satisfaction when they have sex." + }, + { + "input": "Concept: Last Reported Free Visit (Clinical Observation)", + "output": "Clinical Observation described as an indication of the last visit during which an individual was noted to be without something." + }, + { + "input": "Concept: haloether (halocarbon compound)", + "output": "Organic Chemical described as halogenated organic compound with an oxygen linking two carbon atoms." + }, + { + "input": "Concept: study description (Intellectual Product)", + "output": "Description described as specific, essential aspects of an investigation that are detailed, including structure, blinding, dosage, and participant demographics." + }, + { + "input": "Concept: Catheters, Angioplasty, Atherectomy (Medical Device)", + "output": "something described as an intraluminal artery stripper is a device used to perform an endarterectomy (removal of plaque deposits from arterisclerotic arteries.)." + }, + { + "input": "Concept: Testicular Seminoma Pure (Malignant Neoplasms)", + "output": "Primary malignant neoplasm described as a malignant germ cell tumor arising from the testis. It is believed that it is derived from the sexually undifferentiated embryonic gonad. Treatment with radiotherapy is highly successful when the tumor is diagnosed in localized stages, which represents the majority of presentations of seminoma. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C7328\" active clinical trials using this agent." + }, + { + "input": "Concept: Pouch (Quantitative Concept)", + "output": "Quantitative Concept described as a unit of presentation used to represent the quantity of product that is found in a single discrete entity where the pharmaceutical dose form or container is a type of pouch. Comment: For example, to describe the strength of a pouch: \"contains 10 mg per pouch\"." + }, + { + "input": "Concept: Pelvic lymph nodes set (Pelvic lymph node group)", + "output": "Body Part, Organ, or Organ Component described as any lymph node within the abdominal pelvic region." + }, + { + "input": "Concept: lymphocytic leukemia acute (Blood, Heart and Circulation)", + "output": "Lymphoid leukemia described as a form of acute leukemia characterized by excess lympoblasts." + }, + { + "input": "Concept: Other Body Fluids and Secretions (Other Anatomic Concept)", + "output": "Body Substance described as liquid substances produced by living organisms to fulfill specific functions or excreted as waste. Secretions do not include hormones or enzymes." + }, + { + "input": "Concept: CSF-G (Colony-Stimulating Factors)", + "output": "something described as granulocyte colony-stimulating factor (207 aa, ~22 kDa) is encoded by the human CSF3 gene. This protein is involved in the regulation of the production, differentiation, and function of granulocytes." + }, + { + "input": "Concept: Top, Flowering (Plant)", + "output": "something described as tops of plants when in flower, including the stems, leaves and blooms." + }, + { + "input": "Concept: NSCLC106 (NSCLC-SAQ Version 1.0 Questionnaire Question)", + "output": "something described as non-Small Cell Lung Cancer Symptom Assessment Questionnaire v1.0 - How often did you tire easily over the last 7 days?" + }, + { + "input": "Concept: Hematocrit value increased (Hydration)", + "output": "Hematology described as an elevation above the normal ratio of the volume of red blood cells to the total volume of blood." + }, + { + "input": "Concept: STAIN, RETICULOCYTE (Organic Chemical)", + "output": "something described as dye and chemical solution stains for medical purposes are mixtures of synthetic or natural dyes or nondye chemicals in solutions used in staining cells and tissues for diagnostic histopathology, cytopathology, or hematology." + }, + { + "input": "Concept: irRECIST (Intellectual Product)", + "output": "Response Evaluation Criteria in Solid Tumors described as a set of criteria for capturing the unidimensional measurements which are used to assess the effect of immunotherapeutic agents on solid tumors based on elements of Immune-related RECIST (irRECIST)." + }, + { + "input": "Concept: diphosphate:acetate phosphotransferase activity (phosphotransferase activity, carboxyl group as acceptor)", + "output": "phosphotransferase activity, carboxyl group as acceptor described as catalysis of the reaction: acetate + diphosphate = acetyl phosphate + phosphate." + }, + { + "input": "Concept: INFECTION PREGNANCY (Female Reproductive System)", + "output": "Pregnancy and Reproduction described as pregnancy complications caused by microorganism infections; this term applies mainly to the mother and fetus, in contrast to CONGENITAL INFECTION, which applies mainly to the postnatal infant." + }, + { + "input": "Concept: Osteopetrosis hypogammaglobulinaemia syndrome (Hereditary disorder of musculoskeletal system)", + "output": "Autosomal recessive hereditary disorder described as an extremely rare primary bone dysplasia with increased bone density disorder characterised by severe osteoclast-poor osteopetrosis associated with hypogammaglobulinaemia. Patients typically present infantile malignant osteopetrosis (manifesting with increased bone density, bone fractures, abnormal eye movements/visual loss, nystagmus), haematologic abnormalities with bone marrow failure (for example anaemia, hepatosplenomegaly) and immunological deficiency (manifesting as recurrent respiratory infections) associated with reduced immunoglobulin levels due to impaired peripheral B cell differentiation. There is evidence the disease is caused by homozygous or compound heterozygous mutation in the TNFRSF11A gene on chromosome 18q21." + }, + { + "input": "Concept: Nucleic Acid Processors, Sequencing (Medical Device)", + "output": "Medical Device described as nucleic acid processors designed for the automated determination of the precise sequence of the base pairs (i.e., adenine, thymine, cytosine, and guanine for DNA) in a sample of nucleic acid. These devices typically process samples of DNA molecules (labeled with multiple fluorescent dyes) that are loaded onto a gel. Usually, the samples are separated by size using capillary electrophoresis; samples are illuminated and detected using a scanning laser beam, and the results are processed using computer analysis. Electrophoretic separation can be displayed in real time; the sequence of nucleotides for the whole sample (e.g., read lengths as long as several hundred base pairs) is printed after computerized ordering." + }, + { + "input": "Concept: PANSS - Uncooperativeness (PANSS Clinical Classification Question)", + "output": "something described as positive and Negative Syndrome Scale (PANSS) Temperature - Uncooperativeness." + }, + { + "input": "Concept: Intrinsic Membrane Protein (Cell Membrane Proteins)", + "output": "Cell Membrane Proteins described as a protein that is an integral membrane protein with a transmembrane region." + }, + { + "input": "Concept: Fractional Excretion from T1 to T2 (Excretion Rate)", + "output": "Excretion Rate described as the fraction of the administered dose that is recovered from the specimen type, over the interval between T1 and T2." + }, + { + "input": "Concept: Budding Yeast (Microbiology procedure)", + "output": "something described as a measurement of the budding yeast present in a biological specimen." + }, + { + "input": "Concept: anopheles (Eukaryote)", + "output": "something described as genus of mosquitoes in the family Culicidae that are known vectors of malaria." + }, + { + "input": "Concept: CDC Enteric Group 64 (Bacterium)", + "output": "Buttiauxella described as a species of facultatively anaerobic, Gram-negative, rod-shaped bacteria in the family Enterobacteriaceae. B. gaviniae is positive for arginine dihydrolase, 5-ketogluconate, and palatinose reactions and negative for ornithine decarboxylase and raffinose reactions." + }, + { + "input": "Concept: Extraordinary Opportunity: Imaging Technologies (Research Activity)", + "output": "Extraordinary Opportunities for Investment described as goal: to develop a comprehensive imaging research program to fit the development of imaging technology with medical needs to create a system to evaluate new imaging technologies rapidly and effectively." + }, + { + "input": "Concept: cellular zinc ion homeostasis (Cell Function)", + "output": "something described as any process involved in the maintenance of an internal steady state of zinc ions at the level of a cell." + }, + { + "input": "Concept: 36 Months (Temporal Concept)", + "output": "Period described as a period of time of thirty-six months." + }, + { + "input": "Concept: IntAnaly Raw (Intellectual Product)", + "output": "something described as the collection of unprocessed data records used for an interim analysis of results during a clinical trial." + }, + { + "input": "Concept: Plant Hydrocarbon Secretion (Biopolymers)", + "output": "Plant Part described as polymers of high molecular weight which at some stage are capable of being molded and then hardened to form useful components; includes plant resins, oxidation or polymerization products of terpenes." + }, + { + "input": "Concept: RHOMBOTIN 2 (Genes)", + "output": "Gene or Genome described as this gene plays a crucial role in hematopoietic development and is involved in transcriptional activation." + }, + { + "input": "Concept: Sentinel Lymph Node Not Identified (Other Finding)", + "output": "Other Finding described as an indication that sentinel lymph node mapping was attempted but that it did not identify a sentinel lymph node." + }, + { + "input": "Concept: Pharmacoeconomic Study (Research Activity)", + "output": "Clinical Trial Type described as a study that assesses the value associated with a given drug in therapeutic and economic terms. This type of study is multidisciplinary in nature and takes into consideration the social and economic costs (resource utilization costs including direct, indirect, and intangible costs) of drug therapy in addition to its direct therapeutic benefits. Analyses relate the difference in therapeutic benefits to the difference in costs between treatment alternatives." + }, + { + "input": "Concept: CSS1102C (Intellectual Product)", + "output": "C-SSRS Lifetime/Recent Version Questionnaire Question described as columbia-Suicide Severity Rating Scale Lifetime/Recent Version - Description of non-specific active suicidal thoughts." + }, + { + "input": "Concept: Philtrum with central raphe (Abnormality of the philtrum)", + "output": "Abnormality of the philtrum described as narrow ridge in the midline of the philtral groove." + }, + { + "input": "Concept: rnrx speech therapist service (Speech pathology procedure)", + "output": "Otorhinolaryngologic service or procedure described as use of special techniques for correction of speech disorders." + }, + { + "input": "Concept: Cryostats (Medical Devices)", + "output": "Medical Devices described as an instrument designed to cut frozen tissue specimens on the order of micron-scale thickness, generally for the purposes of histolgical evaluation." + }, + { + "input": "Concept: Set of cerebellar peduncles (Peduncle of neuraxis)", + "output": "Brain stem part described as one of three pairs of nerve fiber bundles that originate from the cerebellum and link it to the brainstem." + }, + { + "input": "Concept: External Shock Wave Therapy Systems, Electromagnetic (Medical Device)", + "output": "something described as external shock wave therapy (ESWT) systems designed to produce shockwaves from electromagnetic generators. These systems typically consist of a generator that produces a magnetic field when an electric current circulates through a coil attached to a thin metallic membrane. A shock wave is then generated when the membrane is repelled by the magnetic field. Electromagnetic ESWT systems are intended to produce mechanical and biological effects on tissues. Dedicated systems intended for external fragmentation of renal and gallbladder stones, for orthopedic use, and also for some other applications (e.g., a few dermatologic conditions). Both dedicated systems are intended to produce mechanical and biologic effects for orthopedic use and other applications. Systems that provide strong mechanical effects (i.e., lithotripters) for the destruction of renal and/or gallbladder stones are also available." + }, + { + "input": "Concept: Neoplasm of uncertain behaviour NOS (body system/site cancer)", + "output": "Neoplastic Process described as a neoplasm displaying morphologic, phenotypic, or genotypic characteristics that are clearly not benign but do not permit the establishment of a definitive diagnosis of malignancy. Such neoplasms may or may not eventually have a more aggressive clinical course. Representative examples include lymphoproliferations of uncertain malignant potential (e.g., lymphomatoid granulomatosis and lymphomatoid papulosis), borderline ovarian epithelial neoplasms (e.g., borderline ovarian endometrioid tumor and borderline ovarian mucinous tumor), borderline exocrine pancreatic neoplasm (e.g., pancreatic borderline intraductal papillary-mucinous neoplasm), and primary borderline peritoneal epithelial neoplasm. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C3646\" active clinical trials using this agent." + }, + { + "input": "Concept: Mean Residence Time Last (Mean Residence Time)", + "output": "something described as mean residence time (MRT) from the time of dosing to the time of the last measurable concentration." + }, + { + "input": "Concept: Fetal Lipoma (Benign lipomatous tumor)", + "output": "Benign neoplasm of soft tissue described as benign tumors of fatty tissues found in infancy and childhood. It is associated chromosomal aberrations that result in activation of an oncogene on chromosome band 8q12." + }, + { + "input": "Concept: License Type Code (Intellectual Product)", + "output": "Type Code described as a coded value specifying the kind of license to be able to do or own a specified thing." + }, + { + "input": "Concept: Cerebro-oculo-facio-skeletal syndrome (Syndrome)", + "output": "Multisystem disorder C-D described as a rare degenerative genetic disorder with an autosomal recessive pattern of inheritance that primarily affects the central nervous system. It is caused in some cases by mutations in the Cockayne syndrome group B gene, CSB/ERCC6, or the xeroderma pigmentosum genes: XPD/ERCC2, XPG/ERCC5, XPF/ERCC1, which are all involved in the transcription-coupled nucleotide excision repair pathway of DNA repair. It is currently thought to be part of the spectrum of disorders within Cockayne syndrome. Clinical signs at birth include microcephaly, hypotonia, abnormal reflexes and involuntary eye movements. The clinical prognosis is fatal with survivability beyond 5 years unlikely." + }, + { + "input": "Concept: Supraventricular tachyarrhythmias (Classification)", + "output": "something described as this SMQ is a sub-SMQ of Tachyarrhythmias (incl supraventricular and ventricular tachyarrhythmias) (SMQ), which is itself a sub-SMQ of Cardiac arrhythmia terms (incl bradyarrhythmias and tachyarrhythmias) (SMQ). For detailed description, please refer to the one in Cardiac arrhythmias (SMQ)." + }, + { + "input": "Concept: Proteus rettgeri (Hadley et al. 1918) Rustigian and Stuart 1943 (Bacterium)", + "output": "Providencia described as a species of facultatively anaerobic, Gram-negative, rod shaped bacteria assigned to the phylum Proteobacteria. This species is motile, indole, citrate, and urease positive. P. rettgeri is an opportunistic pathogen associated with nosocomial outbreaks, bacteremia, skin infections, and traveler's diarrhea." + }, + { + "input": "Concept: ligase activity, forming nitrogen-metal bonds (ligase activity)", + "output": "something described as catalysis of the joining of a metal ion to a molecule via a nitrogen-metal bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." + }, + { + "input": "Concept: maintenance of seed dormancy by absisic acid (maintenance of seed dormancy)", + "output": "Cell Function described as the process by which seed dormancy is maintained by the presence of absisic acid." + }, + { + "input": "Concept: Increase in B-type Natriuretic Peptide or N-terminal pro-B-type Natriuretic Peptide (Elevated Test Result)", + "output": "Finding described as a finding of an increased amount of either B-type natriuretic peptide or N-terminal pro-B-type natriuretic peptide" + }, + { + "input": "Concept: Adductor hallucis muscle, oblique head (Body Part, Organ, or Organ Component)", + "output": "Muscle structure of foot described as the larger of two heads of the adductor hallucis muscle. It originates from the sheath of the peroneus longus tendon and the plantar surface of the bases of the second to fourth metatarsal bones in the foot." + }, + { + "input": "Concept: Dental Attachments, Semiprecision, Partial Denture, Implant (Dental Attachments, Semiprecision, Partial Denture)", + "output": "something described as semiprecision partial denture attachments designed to attach the partial denture to receptacles that are connected to dental implants and/or tooth-root (radicular or intraradicular) studs. These attachments are typically two-component devices that attach to each other with a lesser degree of precision than precision attachments: one component is fixed to the abutment (usually a dental implant) and a second component is an integral part of the partial denture base. Rigid and resilient attachments are available that permit a slight vertical, hinging, and/or rotational movement as the patient bites." + }, + { + "input": "Concept: Increased diffusing capacity (Finding)", + "output": "Finding described as increased ability of the lungs to transfer gas from inspired air to the bloodstream as measured by the diffusing capacity of the lungs for carbon monoxide (DLCO) test." + }, + { + "input": "Concept: nopaline degradation (cellular modified amino acid catabolic process)", + "output": "something described as the chemical reactions and pathways resulting in the breakdown of nopaline (N-(I-carboxy-4-guanidinobutyl)glutamic acid), a rare amino-acid derivative." + }, + { + "input": "Concept: SUN DOWNING (Mental state)", + "output": "something described as a syndrome of emergence or increment of neuropsychiatric symptoms, such as confusion and behavioral disturbances, in the late afternoon, early evening or at night." + }, + { + "input": "Concept: Genus Geomyces (Fungus)", + "output": "Ascomycota described as any fungal organism that is not assigned to the species level but can be assigned to the Geomyces genus level." + }, + { + "input": "Concept: Pancreatic Fistulas (Pancreatic duct disorder)", + "output": "something described as abnormal passage communicating with the PANCREAS." + }, + { + "input": "Concept: Beta-2 Adrenoceptor Gene (ADRB2 gene)", + "output": "ADRB2 gene described as human ADRB2 wild-type allele is located within 5q31-q32 and is approximately 2 kb in length. This allele, which encodes beta-2 adrenergic receptor protein, plays a role in the regulation of both calcium channel complex regulation and adenylyl cyclase activity. A variety of polymorphic forms of the gene are associated with nocturnal asthma, obesity and type 2 diabetes. These variants are frequently generated by point mutations and downregulation of the gene." + }, + { + "input": "Concept: GM CSF RECEPT (Receptor)", + "output": "Amino Acid, Peptide, or Protein described as heterodimeric human GM-CSF Receptor is composed of Colony Stimulating Factor 2 Receptor Alpha Chain and Colony Stimulating Factor 2 Receptor Beta Chain. CSF2RA is a type I membrane protein with a box 1 motif for JAK interaction/activation and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. The receptor signal transducing beta chain is common to the high affinity IL3-, IL5- and GM-CSF receptors. CSF2R transduces the CSF2 signal for proliferation, differentiation, and activation of (primarily) granulocyte and macrophage hematopoietic cells." + }, + { + "input": "Concept: C-SSRS BASELINE/SCREENING VERSION (Clinical or Research Assessment Questionnaire)", + "output": "something described as columbia-Suicide Severity Rating Scale (C-SSRS) Baseline/Screening Version 1/14/2009 (Posner, K.; Brent, D.; Lucas, C.; Gould, M.; Stanley, B.; Brown, G.; Fisher, P.; Zelazny, J.; Burke, A.; Oquendo, M.; Mann, J.; copyright 2008 The Research Foundation for Mental Hygiene, Inc.)." + }, + { + "input": "Concept: Reality orientation (rnrx cognitive)", + "output": "Therapeutic or Preventive Procedure described as actions performed to promote the ability to locate oneself in environment" + }, + { + "input": "Concept: HCT/P Distribution (Activity)", + "output": "Activity described as conveyance or shipment of Human Cells, Tissues, and Cellular and Tissue-Based Products (HCT/Ps) that has met all release criteria." + }, + { + "input": "Concept: Anion Transporter Binding (Molecular Function)", + "output": "Molecular Function described as anion Transporter Binding involves temporary non-covalent interaction of a molecule through intermolecular physical forces of attraction with an anion transporter protein that moves the bound ion carrying a negative charge across a cell membrane with or against a concentration gradient." + }, + { + "input": "Concept: regulation of long-day photoperiodism, flowering (regulation of photoperiodism, flowering)", + "output": "something described as any process that modulates the frequency, rate or extent of long-day photoperiodism, where the response associated with the photoperiodism is flowering. Flowering is defined by the switch from the vegetative to the reproductive phase." + }, + { + "input": "Concept: Teniposid (Podophyllotoxin derivative)", + "output": "Pharmacologic Substance described as an anticancer drug that is a podophyllotoxin derivative and belongs to the family of drugs called mitotic inhibitors." + }, + { + "input": "Concept: Monosomy 7 (Chromosome 7 Abnormality)", + "output": "something described as a chromosomal abnormality consisting of the absence of one of the copies of chromosome 7 in somatic cells." + }, + { + "input": "Concept: Protozoal antigen (Microbial antigen)", + "output": "Antigens described as any part or derivative of any protozoan that elicits immunity." + }, + { + "input": "Concept: Mucosal Melanoma (cellular diagnosis, melanoma)", + "output": "Non-Cutaneous Melanoma described as a melanoma that arises from a mucosal site." + }, + { + "input": "Concept: Orntlhrb/ntrlsubst dspnsg nc (Therapeutic or Preventive Procedure)", + "output": "Preparing and/or dispensing and/or training services with or without ICD diagnosis described as dispensing an Oriental herb(s) and/or natural substance(s). Use in conjunction with the appropriate ADX code. Service is billed as a no-charge item." + }, + { + "input": "Concept: UHDR183A (Intellectual Product)", + "output": "Intellectual Product described as unified Huntington's Disease Rating Scale '99 - Since the last visit, has the subject been permanently institutionalized?" + }, + { + "input": "Concept: NPI - Talk to Total Strangers as if He/She Knew Them (NPI Questionnaire Question)", + "output": "something described as neuropsychiatric Inventory (NPI) Does the patient talk to total strangers as if he/she knew them?" + }, + { + "input": "Concept: cush disease (ENDOCRINE FEATURES)", + "output": "ACTH-dependent Cushing's syndrome described as cushing's syndrome due to abnormally high secretion of adrenocorticotropic hormone (ACTH) from the pituitary gland." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, SDHD (Medical Device)", + "output": "something described as molecular assay reagents intended to identify deletions or duplications of the succinate dehydrogenase complex subunit D (SDHD) gene, located at chromosome 11q23.1, which encodes the mitochondrial protein succinate dehydrogenase [ubiquinone] cytochrome b small subunit. Genetic variants at this locus have been associated with carcinoid tumor of the intestine; Cowden syndrome; mitochondrial complex II deficiency; paraganglioma and gastric stromal sarcoma; paragangliomas; and pheochromocytoma." + }, + { + "input": "Concept: medulloblastoma brain tumor (Medulloblastoma)", + "output": "Cerebellar Diseases described as a rapidly growing embryonic tumor arising in the posterior part of the cerebellar vermis and neuroepithelial roof of the fourth ventricle in children. More rarely, medulloblastoma arises in the cerebellum in adults." + }, + { + "input": "Concept: positive regulation of mannan catabolism (Molecular Function)", + "output": "Molecular Function described as any process that activates or increases the frequency, rate or extent of mannan catabolic process." + }, + { + "input": "Concept: cell cortex (Cytoplasm)", + "output": "something described as the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." + }, + { + "input": "Concept: Grade 1 Serum Sickness, CTCAE (Serum Sickness, CTCAE 5.0)", + "output": "Finding described as asymptomatic; clinical or diagnostic observations only; intervention not indicated" + }, + { + "input": "Concept: N1SLPTST (Laboratory Procedure)", + "output": "Polysomnography described as the determination of the ratio of N1 sleep time compared to total sleep time. The measurement may be expressed as a ratio or percentage." + }, + { + "input": "Concept: Equus caballus gmelini X Equus caballus caballus (Genus equus)", + "output": "Genus equus described as intersubspecies equine hybrid" + }, + { + "input": "Concept: Malonates (Dicarboxylic Acids)", + "output": "Organic Chemical described as derivatives of malonic acid (the structural formula CH2(COOH)2), including its salts and esters." + }, + { + "input": "Concept: Dentalis, Alveolus (Skeletal System Part)", + "output": "Cavity of organ part described as one of the cavities or sockets in the alveolar process of the mandible or maxilla, in which the roots of the teeth are held by fibers of the periodontal ligament; called also alveolar cavities and tooth sockets." + }, + { + "input": "Concept: Trabeculectomy (Ophthalmologic Surgical Procedures)", + "output": "Surgical repair procedure by body site described as any surgical procedure for treatment of glaucoma by means of puncture or reshaping of the trabecular meshwork. It includes goniotomy, trabeculectomy, and laser perforation." + }, + { + "input": "Concept: EKG: right bundle branch block (Electrocardiogram abnormal)", + "output": "Viscus structure finding described as an electrocardiographic finding of a wide QRS complex with evidence of delayed conduction to the right ventricle, manifest by a widened initial portion of the QRS in V1 and V2, a widened S wave in V5, V6, I and aVL, and with QRS duration greater than or equal to 120 ms. An RsR' complex is typically present in leads V1 and V2." + }, + { + "input": "Concept: FMS-Related Tyrosine Kinase 3 c.1992G>A (Non-synonymous FLT3 Gene Mutation)", + "output": "Cell or Molecular Dysfunction described as a nucleotide substitution at position 1992 of the coding sequence of the FLT3 gene where guanine has been mutated to adenine." + }, + { + "input": "Concept: N-terminal peptidyl-serine monomethylation (Molecular Function)", + "output": "something described as the monomethylation of the N-terminal serine of proteins to form the derivative N-methylserine." + }, + { + "input": "Concept: VON WILLEBRAND DISEASE, PLATELET-TYPE (von Willebrand Disease)", + "output": "Hereditary platelet function disorder described as a rare autosomal dominant bleeding disorder characterized by abnormally enhanced binding of von Willebrand factor (VWF) by the platelet glycoprotein Ib receptor complex. Hemostatic function is impaired due to the removal of VWF multimers from the circulation. It is due to a mutation in the gene encoding for platelet glycoprotein Ib alpha, resulting in enhanced affinity for VWF. It is often misdiagnosed as type 2B von Willebrand disease due to similarities between these two conditions. Patients present with a mild thrombocytopenia with large platelets. Platelet aggregates are often visible in blood smears." + }, + { + "input": "Concept: Lensometers, Automated (Lensometer)", + "output": "something described as lensometers designed for the automated measurement of the optical characteristics of spectacle and/or contact lenses (e.g. spherical power, cylinder power, cylinder axis, prismatic power, lens diameter). The instruments consist mainly of light sources, a lens mount, microprocessor, camera imaging devices, and a display. They use an imaging camera to capture the patterns of light projected from the lens and analyze the result automatically. Automated lensometers are used mainly to determine whether the lens characteristics and the prescription match." + }, + { + "input": "Concept: Renal Pelvis and Ureter Cancer Pathologic TNM Finding v7 (Finding)", + "output": "Finding described as a pathologic finding about one or more characteristics of renal pelvis and ureter cancer, following the rules of the TNM AJCC v7 classification system. Pathologic staging depends on histologic determination of the extent of invasion by the primary tumor." + }, + { + "input": "Concept: formoterol fumarate oral (Pharmacologic Substance)", + "output": "Adrenergic beta-Agonists described as the orally bioavailable fumarate salt of formoterol, a long-acting, selective beta2-adrenergic receptor agonist with bronchodilating and potential anti-cachexia and anabolic activities. In addition to formoterol's bronchodilating activity, formoterol exhibits anti-cachexia activity through the inhibition of the ATP-ubiquitin-dependent proteolytic system, which may result in a decrease in protein degradation and muscle cell apoptosis. In addition, formoterol may also increase insulin-like growth factor (IGF) signaling, resulting in an increase in protein synthesis. This agent may also inhibit the calcium-dependent calpain system, resulting in the inhibition of muscle wasting. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C85467\" active clinical trials using this agent." + }, + { + "input": "Concept: CVSTRESC (Character Result or Finding in Standard Format)", + "output": "Character Result or Finding in Standard Format described as the standard character or string for representation and reporting of cardiovascular system findings data." + }, + { + "input": "Concept: Surgical Retractor Kits, Spine, Total (Surgical Retractor Kits, Spine)", + "output": "Surgical Retractor Kits, Spine described as spine surgery retractor kits designed for use while performing procedures involving any or all of the spine (i.e., backbones) segments. These kits typically consist of a collection of devices, instruments, and supplies combined to temporarily separate and retain tissue or other anatomical parts, exposing and/or giving access to the appropriate segment of the spine without manual support once they are set (i.e., self-retained). The kits frequently include a flexible ring, a set of detachable blades which provide lateral retraction, ratchet mechanisms to adjust retractor tension and depth, and a fixation post that may be attached to the operating table or a stand. Total spine retractor kits provide hands-free assistance to the surgeon during the procedure." + }, + { + "input": "Concept: Long axis (Spatial Concept)", + "output": "Axis described as line through and in the direction of an object's characteristic feature that is longer than any other feature." + }, + { + "input": "Concept: Apolipoprotein A1/Apolipoprotein B (Laboratory Procedure)", + "output": "Laboratory Procedure described as the determination of the ratio of apolipoprotein A1 compared to apolipoprotein B present in a sample. The measurement may be expressed as a ratio or percentage." + }, + { + "input": "Concept: Hyperextensible thumb (Hyperextensible hand joints)", + "output": "Hyperextensible hand joints described as the ability of the thumb joints to move beyond their normal range of motion." + }, + { + "input": "Concept: Abnormal dense granules (Abnormal platelet granules)", + "output": "something described as defective structure, size or content of dense granules, platelet organelles that contain granules proaggregatory factors such as adenosine diphosphate (ADP), adenosine triphosphate (ATP), ionized calcium , histamine and serotonin." + }, + { + "input": "Concept: type II transmembrane protein insertion into ER membrane (Cell Function)", + "output": "Cell Function described as a process of protein insertion into the endoplasmic reticulum (ER) membrane in which a tail-anchored (TA) transmembrane protein is incorporated into an endoplasmic reticulum (ER) membrane. TA transmembrane protein, also named type II transmembrane proteins, contain a single C- terminal transmembrane region." + }, + { + "input": "Concept: sodium channel complex (Cell Component)", + "output": "something described as an ion channel complex through which sodium ions pass." + }, + { + "input": "Concept: NADP (reduced) binding (anion binding)", + "output": "Molecular Function described as interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions." + }, + { + "input": "Concept: Malignant Eye Neoplasm, Miscellaneous (NCI CTEP SDC Eye Neoplasm Category Terminology)", + "output": "something described as malignant Eye Neoplasm, Miscellaneous is an NCI Cancer Therapeutic Evaluation Program (CTEP) Simplified Disease Classification (SDC) category used to organize cancer-related disease coding that harmonizes with and supports reporting based on the global standard Medical Dictionary for Drug Regulatory Reporting (MedDRA) terminology." + }, + { + "input": "Concept: Cleavage and Polyadenylation Factor (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as factors that are involved in directing the cleavage and POLYADENYLATION of the of MESSENGER RNA near the site of the RNA 3' POLYADENYLATION SIGNALS." + }, + { + "input": "Concept: Ovarian Carcinoma by FIGO Stage 2014 (Neoplastic Process)", + "output": "Carcinoma, Ovarian Epithelial described as a category of staging terms for ovarian cancer according to the International Federation of Gynecology and Obstetrics (FIGO), 2014. AJCC ovarian cancer stage terms from the 6th and 7th editions that are synonymous to the FIGO ovarian cancer staging classification of 2014 are included as preferred terms." + }, + { + "input": "Concept: Influenza C Viruses (Virus)", + "output": "Influenzavirus C described as a negative sense single-stranded RNA virus of the orthomyxovirus family that can cause a rare form of influenza. Its genome consists of 7 RNA segments that encode 9 proteins." + }, + { + "input": "Concept: Replication Timings, DNA (Replication-Associated Process)", + "output": "Replication-Associated Process described as the temporal order in which the DNA of the GENOME is replicated." + }, + { + "input": "Concept: membrane raft organization (Cell Function)", + "output": "Cell Function described as a process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." + }, + { + "input": "Concept: Cervical smear - borderline change in endocervical cells (Finding)", + "output": "something described as crowded cells with pseudostratification but little nuclear abnormality, or coarsely clumped chromatin with entirely normal architecture." + }, + { + "input": "Concept: CYCHOL (Laboratory Procedure)", + "output": "Laboratory Procedure described as a measurement of the cholesterol crystals present in a biological specimen." + }, + { + "input": "Concept: RO7009789 (Pharmacologic Substance)", + "output": "Amino Acid, Peptide, or Protein described as a monoclonal antibody agonist of the cell surface receptor CD40, with potential immunostimulatory and antineoplastic activities. Similar to the endogenous CD40 ligand (CD40L or CD154), CD40 agonist monoclonal antibody RO7009789 binds to CD40 on a variety of immune cell types. This triggers the cellular proliferation and activation of antigen-presenting cells (APCs), and activates B cells and T cells, resulting in an enhanced immune response. RO7009789 also binds to and activates CD40 present on the surfaces of some solid tumor cells, leading to apoptosis and decreased tumor growth. CD40, a cell surface receptor and member of the tumor necrosis factor (TNF) receptor superfamily, is expressed on various immune cells and certain cancer cells; it mediates both indirect tumor cell killing through the activation of the immune system and direct tumor cell apoptosis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C119740\" active clinical trials using this agent." + }, + { + "input": "Concept: up regulation of mRNA polyadenylylation (Genetic Function)", + "output": "Genetic Function described as any process that activates or increases the frequency, rate or extent of mRNA polyadenylation." + }, + { + "input": "Concept: Granulocytic cells (Blood product)", + "output": "Cell described as leukocytes with abundant neutrophilic, eosinophilic or basophilic granules in the cytoplasm; mature granulocytes are the neutrophils, eosinophils, and basophils." + }, + { + "input": "Concept: ANTISERUM, CF, RUBEOLA (Indicator, Reagent, or Diagnostic Aid)", + "output": "Indicator, Reagent, or Diagnostic Aid described as rubeola (measles) virus serological reagents are devices that consist of antigens and antisera used in serological tests to identify antibodies to rubeola virus in serum. The identification aids in the diagnosis of measles and provides epidemiological information on the disease. Measles is an acute, highly infectious disease of the respiratory and reticuloendothelial tissues, particularly in children, characterized by a confluent and blotchy rash." + }, + { + "input": "Concept: Duration of menstrual cycle (Duration measure of menstruation)", + "output": "Finding of measures of menstruation described as the length of time of the menses cycle, measured from the beginning of one menstrual period to the beginning of the next." + }, + { + "input": "Concept: Irritable (Mental Process)", + "output": "something described as feelings of annoyance, impatience, and anger." + }, + { + "input": "Concept: bFGF (Amino Acid, Peptide, or Protein)", + "output": "Fibroblast Growth Factor described as fibroblast growth factor 2 (288 aa, ~31 kDa) is encoded by the human FGF2 gene. This protein plays a role in the regulation of cell proliferation, angiogenesis, and limb and nervous system development." + }, + { + "input": "Concept: AFRICAN MED TRADITIONAL (Traditional Medicine)", + "output": "Spiritual Therapies described as a system of traditional medicine which is based on the beliefs and practices of the African peoples. It includes treatment by medicinal plants and other materia medica as well as by the ministrations of diviners, medicine men, witch doctors, and sorcerers." + }, + { + "input": "Concept: Contracture of the distal interphalangeal joint of the 2nd finger (Finding)", + "output": "Finding described as chronic loss of joint motion of the distal interphalangeal joint of the 2nd finger due to structural changes in non-bony tissue." + }, + { + "input": "Concept: Leiomyosarcoma and Endometrial Stromal Sarcoma pT3b TNM Finding v7 (Finding)", + "output": "Leiomyosarcoma and Endometrial Stromal Sarcoma pT3 TNM Finding v7 described as tumor infiltrates abdominal tissues, more than one site." + }, + { + "input": "Concept: Category Type (Type - attribute)", + "output": "Type - attribute described as a description of a category." + }, + { + "input": "Concept: somite specification (segment specification)", + "output": "Organism Function described as the process in which individual somites establish identity during embryogenesis." + }, + { + "input": "Concept: glucose catabolic process to lactate via pyruvate (NAD metabolic process)", + "output": "NAD metabolic process described as the anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, via canonical glycolysis, yielding energy in the form of adenosine triphosphate (ATP)." + }, + { + "input": "Concept: sucrose (Homeopathic remedies letter S)", + "output": "something described as sucrose, cane sugar." + }, + { + "input": "Concept: Temperature Compensator Device (Manufactured Object)", + "output": "something described as a device designed to vary the temperature of one system in response to temperature changes in another system or the environment." + }, + { + "input": "Concept: regulation of phosphatidylcholine catabolic process (Molecular Function)", + "output": "regulation of phospholipid catabolic process described as any process that modulates the rate, frequency or extent of phosphatidylcholine catabolism. Phosphatidylcholine catabolic processes are the chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." + }, + { + "input": "Concept: CRQ0201 (CRQ-SAS Follow-Up Administration Version Questionnaire Question)", + "output": "Intellectual Product described as chronic Respiratory Questionnaire Self-Administered Standardized Format (CRQ-SAS) Follow-up Administration Version - Feeling emotional such as angry or upset." + }, + { + "input": "Concept: down-regulation of X chromosome inactivation (Cell Function)", + "output": "Cell Function described as any process that stops, prevents or reduces the frequency, rate or extent of dosage compensation, by inactivation of X chromosome." + }, + { + "input": "Concept: Anal MANEC (Carcinoma of anal canal)", + "output": "something described as a carcinoma that arises from the anal canal. It is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component. At least 30 percent of either component should be present for the diagnosis to be made." + }, + { + "input": "Concept: TOOLS, PACEMAKER SERVICE (Medical Device)", + "output": "something described as pacemaker service tools are devices such as screwdrivers and Allen wrenches, used to repair a pacemaker lead or to reconnect a pacemaker lead to a pacemaker generator." + }, + { + "input": "Concept: Camptothecin Analogue (Topoisomerase I Inhibitors)", + "output": "Organic Chemical described as an anticancer drug related in structure to camptothecin, a topoisomerase inhibitor. One such drug is aminocamptothecin." + }, + { + "input": "Concept: PHQ0306A (Intellectual Product)", + "output": "something described as patient Health Questionnaire Screener Version - Do you often feel that you can't control what or how much you eat?" + }, + { + "input": "Concept: Procedure Kit/Trays, Emergency, Burn (Procedure Kit/Trays, Emergency)", + "output": "something described as prepackaged collections of the devices and supplies (i.e., either custom or standard kits) needed for initial emergency burn treatment. Items in these kits usually include burn ointments and sterile sheets, towels, gloves, bandages, and water appropriate for burn treatment. The kits are frequently supplied in supporting trays (i.e., procedure trays) consisting of a flat-bottomed receptacle with a border around the periphery supporting all the instruments and supplies needed for the procedure; the trays are usually covered or wrapped. Burn emergency procedure kits and trays are intended for use during procedures for the initial treatment of thermal, friction, electrical, and chemical burns. They are used in the field, at home, in emergency rooms, and in other healthcare facilities." + }, + { + "input": "Concept: Grade 4 Cholecystitis, CTCAE (Cholecystitis, CTCAE 5.0)", + "output": "Finding described as life-threatening consequences; urgent operative intervention indicated" + }, + { + "input": "Concept: positive regulation of toll-like receptor 15 signaling pathway (Molecular Function)", + "output": "positive regulation of toll-like receptor signaling pathway described as any process that activates or increases the frequency, rate or extent of toll-like receptor 15 signaling pathway." + }, + { + "input": "Concept: Third-degree perineal laceration during delivery (Third degree perineal laceration)", + "output": "Disease of the digestive system complicating pregnancy, childbirth and/or the puerperium described as injury to perineum involving anal sphincter complex." + }, + { + "input": "Concept: Enlarged internal auditory canal (Finding)", + "output": "Abnormality of the internal auditory canal described as the presence of a dilated inner part of external acoustic meatus." + }, + { + "input": "Concept: positive regulation of dentin-containing tooth bud formation by mesenchymal-epithelial signaling (Organ or Tissue Function)", + "output": "positive regulation of odontogenesis of dentin-containing tooth described as any process that initiates the formation of a tooth bud by the secretion of a signal from a mesenchymal cell and its reception and subsequent change in the identity of an epithelial cell of the tooth bud." + }, + { + "input": "Concept: downregulation of protein localisation in nucleolus (Cell Function)", + "output": "negative regulation of protein localization to nucleus described as any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleolus." + }, + { + "input": "Concept: Acquired Tissue Factor Deficiency (Acquired coagulation factor deficiency)", + "output": "Acquired coagulation factor deficiency described as an acquired coagulation disorder characterized by the partial or complete absence of tissue factor (factor III) activity in the blood." + }, + { + "input": "Concept: extracellular sequestration of iron ion (sequestering of iron ion)", + "output": "something described as the process of binding or confining iron ions in an extracellular area such that they are separated from other components of a biological system." + }, + { + "input": "Concept: Phase-Contrast Microscopy (Light Microscopy)", + "output": "Microscopy technique described as a microscopic technique in which the amplitude shift that occurs when light passes through a specimen highlights structures or details within the specimen." + }, + { + "input": "Concept: Childhood Pleomorphic Xanthoastrocytoma (Neoplastic Process)", + "output": "Pleomorphic Xanthoastrocytoma described as a pleomorphic xanthoastrocytoma that occurs during childhood." + }, + { + "input": "Concept: Deep Inspiration Breath Hold (Active Breathing Control)", + "output": "Active Breathing Control described as a type of active breathing control where a breath is held during a procedure while the lungs are fully expanded. It is typically used during radiation therapy to help limit radiation to underlying organs." + }, + { + "input": "Concept: Increased Sputum Excretion (Physical findings)", + "output": "Respiratory System Finding described as coughing up and spitting out of an overproduction of mucus in the respiratory tract in reaction to a constantly recurring irritant." + }, + { + "input": "Concept: Gram-Positive Microaerophilic Bacillus (Gram-Positive Rods)", + "output": "Gram-Positive Rods described as any rod-shaped bacteria whose growth requires lower than atmospheric oxygen level and has a peptidoglycan-rich cell wall that stains dark purple with the Gram staining technique." + }, + { + "input": "Concept: Esophagitis (gastrointestinal)", + "output": "Non-Neoplastic Esophageal Disorder described as INFLAMMATION, acute or chronic, of the ESOPHAGUS caused by BACTERIA, chemicals, or TRAUMA." + }, + { + "input": "Concept: Labour and employment policies (Governmental or Regulatory Activity)", + "output": "Governmental or Regulatory Activity described as legislation, regulations and standards that govern the distribution of occupations and other forms of remunerative work in the economy, such as standards and policies for employment creation, employment security, designated and competitive employment, labour standards and law, and trade unions." + }, + { + "input": "Concept: Exercisers, Computer-Aided Training, Balance (Exercisers, Computer-Aided Training)", + "output": "Medical Device described as computer-aided training exercisers designed to assess and train a patient for balance. These exercisers typically consist of a force platform with handle rails, a screen that displays biofeedback information, and a computerized unit that monitors, compares, and analyzes the user's performance using test (static or dynamic) modes and/or or trains patient with static or dynamic training modes. Computer-aided training balance exercisers display real-time, visual feedback on screens during the balance test or training that patients can use to adjust their posture and balance. The devices are intended to assess and/or improve balance and the body's ability to sense and regulate the posture and movements using sensory receptors (proprioception). Computer-aided training exercisers are used mainly for programmed exercises, training, and/or physical therapy and rehabilitation." + }, + { + "input": "Concept: HIRUDIN (Anticoagulants)", + "output": "something described as single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN." + }, + { + "input": "Concept: Narcoanalysis (Psychiatric Somatic Therapies)", + "output": "Therapeutic or Preventive Procedure described as sleep-like state induced by medication or hypnosis and used in the treatment of mental disorders." + }, + { + "input": "Concept: PASI - Head (H): Infiltration (PASI Clinical Classification Question)", + "output": "PASI Clinical Classification Question described as psoriasis Area and Severity Index - Head (H): Infiltration (I)." + }, + { + "input": "Concept: Epstein-Barr Virus Associated Nephrotic Syndrome (Nephrotic Syndrome)", + "output": "Nephrotic Syndrome described as nephrotic syndrome associated with Epstein-Barr infection." + }, + { + "input": "Concept: blood pressure regulation by capillary fluid shift (Organism Function)", + "output": "regulation of systemic arterial blood pressure by physical factors described as the intrinsic circulatory process resulting from capillary fluid shift that modulates the force with which blood travels through the systemic arterial circulatory system. Capillary fluid shift is the movement of fluid across the capillary membrane between the blood and the interstitial fluid compartment." + }, + { + "input": "Concept: MSQL111 (Intellectual Product)", + "output": "something described as multiple Sclerosis Quality of Life-54 Instrument - Does your health limit you in these activities: Walking one block." + }, + { + "input": "Concept: STSTDTC (Intellectual Product)", + "output": "Study Start Date described as the date on which the protocol is signed by the study director. Also known as Study Initiation Date." + }, + { + "input": "Concept: Reg Flnote (Note)", + "output": "something described as documentation of any decision or clarification of any information relating to the Regulatory category." + }, + { + "input": "Concept: Shower Chairs (Medical Device)", + "output": "Chairs described as chairs with back- and siderests that provide support to balance impaired patients while taking a shower. Shower chairs must permit easy drainage and full accessibility to all body surfaces. These chairs are usually made of rustproof metals and/or plastics. Most of these chairs include swivel casters that permit the transport of the patient from the bed to the shower." + }, + { + "input": "Concept: Neoplasm of Colon (Colonic Mass)", + "output": "something described as tumors or cancer of the COLON." + }, + { + "input": "Concept: Electrical Current (Physical Phenomenon or Property)", + "output": "Physical Phenomenon or Property described as the movement of electrical charges in a conductor." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, CASR (Medical Device)", + "output": "Medical Device described as molecular assay reagents intended to identify deletions or duplications of the calcium sensing receptor (CASR) gene, located at chromosome 3q13, which encodes the protein extracellular calcium-sensing receptor. Genetic variants at this locus have been associated with idiopathic generalized epilepsy 8, familial hypocalciuric hypercalcemia type 1, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia 1." + }, + { + "input": "Concept: SCC3 Homolog 2 Protein Variant (Gene Product Sequence Variation)", + "output": "something described as a variation in the amino acid sequence for the cohesin subunit SA-2 protein." + }, + { + "input": "Concept: C.B-17/IcrCrl-scid-BR (SCID Mice)", + "output": "SCID Mice described as discovered by Bosma (1980) at Fox Chase Cancer Center, the CB17 SCID mouse has an autosomal recessive mutation in the Prkdc gene which causes a severe combined immunodeficiency affecting B and T lymphocytes." + }, + { + "input": "Concept: Halotestin Regimen (Regimen Used to Treat Breast Carcinoma)", + "output": "Therapeutic or Preventive Procedure described as a hormone therapy regimen consisting of fluoxymesterone that may be used in the treatment of breast cancer." + }, + { + "input": "Concept: Peginterferon Alfa-2a Regimen (Therapeutic or Preventive Procedure)", + "output": "something described as a chemotherapy regimen consisting of peginterferon alfa-2a that may be used in the treatment of myeloproliferative neoplasms and systemic mastocytosis." + }, + { + "input": "Concept: Ethylamines (Amines)", + "output": "something described as derivatives of ethylamine (the structural formula CH3CH2NH2)." + }, + { + "input": "Concept: Stage IVA Carcinoma of the Nasopharynx (Stage IV Nasopharyngeal Carcinoma AJCC v7)", + "output": "Stage IV Nasopharyngeal Carcinoma AJCC v7 described as stage IVA includes: (T4, N0, M0); (T4, N1, M0); (T4, N2, M0). T4: Nasopharyngeal cancer with intracranial extension and/or involvement of cranial nerves, hypopharynx, orbit, or with extension to the infratemporal fossa/masticator space. N0: No regional lymph node metastasis. N1: Nasopharyngeal cancer with unilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa, and/or unilateral or bilateral, retropharyngeal lymph nodes, 6 cm or less in greatest dimension. Midline nodes are considered ipsilateral nodes. N2: Nasopharyngeal cancer with bilateral metastasis in cervical lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa. Midline nodes are considered ipsilateral nodes. M0: No distant metastasis." + }, + { + "input": "Concept: SYRINGOMYELIA/HYDROMYELIA (Syringomyelia)", + "output": "something described as syringomyelia associated with accumulation of cerebrospinal fluid in the spinal cord." + }, + { + "input": "Concept: Hand somatic dysfunction (Somatic dysfunction)", + "output": "nonallopathic lesion of upper extremities described as impaired or altered function of the hand." + }, + { + "input": "Concept: Older Population (Population Group)", + "output": "Population Group described as the population of retired people, generally over 62" + }, + { + "input": "Concept: Guanidines (Amidines)", + "output": "Organic Chemical described as a family of iminourea derivatives. The parent compound has been isolated from mushrooms, corn germ, rice hulls, mussels, earthworms, and turnip juice. Derivatives may have antiviral and antifungal properties." + }, + { + "input": "Concept: Hexaphosphate, Inositol (Antioxidants)", + "output": "Antioxidants described as a substance found in many foods that come from plants, including corn, wheat, rice, and soybeans, and in large amounts in cereals and legumes. It is being studied in the prevention of cancer." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, WT1 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)", + "output": "something described as molecular assay reagents intended to identify deletions or duplications of the Wilms tumor 1 (WT1) gene, located at chromosome 11p13, which encodes the Wilms tumor protein. Genetic variants at this locus have been associated with aniridia, diffuse mesangial sclerosis, Drash syndrome, Frasier syndrome, Meacham syndrome, mesothelioma, and Wilms tumor." + }, + { + "input": "Concept: betamethasone valerate (Pregnanes)", + "output": "Glucocorticoids described as the 17-valerate derivative of BETAMETHASONE. It has substantial topical anti-inflammatory activity and relatively low systemic anti-inflammatory activity." + }, + { + "input": "Concept: Renal Dysplasia-Limb Defects Syndrome (Renal dysplasia)", + "output": "Autosomal recessive hereditary disorder described as syndrome with characteristics of renal dysplasia, growth retardation, phocomelia or mesomelia, radiohumeral fusion, rib abnormalities, anomalies of the external genitalia and a potter-like facies. The syndrome has been described in three infants, all of whom died shortly after birth from respiratory distress resulting from pulmonary hypoplasia and oligohydramnios caused by renal dysplasia. The mode of transmission appears to be autosomal recessive." + }, + { + "input": "Concept: Labor, first stage (Labor finding)", + "output": "Labor Onset described as the stage of the labor and childbirth process when the uterine contractions become strong and regular with cervical effacement and complete dilation of the cervix." + }, + { + "input": "Concept: Otic drops solution (Biomedical or Dental Material)", + "output": "Otic Solution described as liquid single-dose or multidose preparation consisting of an aqueous or oily solution intended for application to the external auditory meatus. Multidose containers may be dropper containers or containers provided with a dropper applicator, or the dropper may be supplied separately. Drops are not necessarily administered dropwise, but may also be administered as a small volume." + }, + { + "input": "Concept: MLL-SARNP Fusion Protein (Fusion protein)", + "output": "something described as a fusion protein encoded by the MLL/SARNP fusion gene. This protein is comprised of the N-terminal half of the histone-lysine N-methyltransferase MLL protein, including the AT hook DNA binding domain and the DNA methyltransferase domain, fused to most of the SAP domain-containing ribonucleoprotein, including the SAP and nuclear localization domains." + }, + { + "input": "Concept: CCND3 Mutation (Cell or Molecular Dysfunction)", + "output": "Gene Mutant described as a change in the nucleotide sequence of the CCND3 gene." + }, + { + "input": "Concept: Vascular Scissors, Microsurgery (Medical Device)", + "output": "Vascular scissors described as vascular surgical scissors designed for fine and sharp dissection of blood vessels in microsurgical procedures. These scissors are typically very small handheld, manual instruments with two straight or curved metallic (e.g., stainless steel) and frequently beveled blades with tips specially shaped to avoid vessel slipping and appropriate for roughening artery ends that slide past each other (i.e., shearing action). The blades are usually attached to serrated flat handles to to provide a safer grip; the handles also have inserted flat springs to avoid uneven tension and to provide a more uniform and/or sensitive manipulation. Vascular microsurgery scissors are mainly used in neurosurgery and plastic surgery." + }, + { + "input": "Concept: Well-Differentiated or De-Differentiated New Tumor (CPTAC Questions)", + "output": "CPTAC Questions described as a question about whether a new tumor is well-differentiated or de-differentiated." + }, + { + "input": "Concept: modulation by symbiont of host digestive system process (modulation by symbiont of host process)", + "output": "modulation by symbiont of host process described as the alteration by a symbiont organism of the functioning of a digestive system process, a physical, chemical, or biochemical process carried out by the host organism to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." + }, + { + "input": "Concept: CNS Neoplasm (NCI CTEP Simplified Disease Classification Terminology)", + "output": "something described as CNS Neoplasm (Primary Tumor) is an NCI Cancer Therapeutic Evaluation Program (CTEP) Simplified Disease Classification (SDC) category used to organize cancer-related disease coding that harmonizes with and supports reporting based on the global standard Medical Dictionary for Drug Regulatory Reporting (MedDRA) terminology." + }, + { + "input": "Concept: 6-(2-(1H-Imidazol-4-yl)ethylamino)-5-oxohexanoic acid (Biologically Active Substance)", + "output": "something described as an orally bioavailable small molecule, with potential hematopoiesis inducing and antiviral activities. Upon oral administration, myelo001 stimulates the differentiation of bone marrow cells of the leukocytic, lymphocytic, and erythrocytic lineages, and prevents apoptosis of hematopoietic cells. This prevents chemotherapy-induced neutropenia (CIN), inhibits the risk of infections, increases tolerance and allows for the continuation of the neutropenia-inducing chemotherapeutic agent. In addition, myelo 001 has antiviral properties." + }, + { + "input": "Concept: L-glutamate:NAD(P)+ oxidoreductase (oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor)", + "output": "oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor described as catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+." + }, + { + "input": "Concept: Hallucinations (Sensory Manifestations)", + "output": "Delusions described as subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real; may be of organic origin, drug induced, or associated with a mental disorder." + }, + { + "input": "Concept: REPLACEMENT, TOTAL OSSICULAR, PROSTHESIS, POROUS, POLYETHYLENE (Medical Device)", + "output": "something described as a total ossicular replacement prosthesis is a device intended to be implanted for the total functional reconstruction of the ossicular chain and facilitates the conduction of sound waves from the tympanic membrance to the inner ear. The device is made of materials such as polytetrafluoroethylene, polytetrafluoroethylene with vitreous carbon fibers composite, porous polyethylene, or from a combination of these materials." + }, + { + "input": "Concept: Cefotiam Hydrochloride (Antibiotic)", + "output": "C [Preparations] described as the hydrochloride salt form of cefotiam, a third-generation, semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Cefotiam binds to penicillin-binding proteins (PBPs), transpeptidases that are responsible for crosslinking of peptidoglycan. By preventing crosslinking of peptidoglycan, cell wall integrity is lost and cell wall synthesis is halted." + }, + { + "input": "Concept: Cloacal exstrophy (Congenital Abnormality)", + "output": "Congenital genitourinary tract anomalies NEC described as cloacal exstrophy is a severe anterior abdominal wall defect in which the two hemibladders are visible and are separated by a midline intestinal plate, an omphalocele, and an imperforate anus." + }, + { + "input": "Concept: Sphingosine Phosphorylcholine Receptors (Receptor)", + "output": "Receptors, Lysosphingolipid described as a subfamily of lysophospholipid receptors with specificity for lysophosphatidic acid." + }, + { + "input": "Concept: Gardnerella vaginalis (Laboratory Procedure)", + "output": "something described as a measurement of the Gardnerella vaginalis in a biological specimen." + }, + { + "input": "Concept: RADIOIMMUNOASSAY, DIGOXIN (3-H), RABBIT ANTIBODY, CHARCOAL SEP. (Indicator, Reagent, or Diagnostic Aid)", + "output": "something described as a digoxin test system is a device intended to measure digoxin, a cardiovascular drug, in serum and plasma. Measurements obtained by this device are used in the diagnosis and treatment of digoxin overdose and in monitoring levels of digoxin to ensure appropriate therapy." + }, + { + "input": "Concept: Angiotensin-2, Human (Hormone)", + "output": "something described as angiotensin-2 (8 aa, ~1 kDa) is encoded by the human AGT gene. This protein is involved in vasoconstriction, heart rate and renal absorption of water and sodium." + }, + { + "input": "Concept: Sick Newborn (Newborn or Infant Finding)", + "output": "Newborn or Infant Finding described as a neonate that is unwell." + }, + { + "input": "Concept: fibrous protein (proteins by body part)", + "output": "Proteins described as simple proteins characterized by their insolubility and fibrous structure. Within the body, they perform a supportive or protective function." + }, + { + "input": "Concept: Mansonella (Family Filariidae)", + "output": "Filaroididae described as a genus of parasitic nematodes whose organisms are distributed in Central and South America. Characteristics include a smooth cuticle and an enlarged anterior end." + }, + { + "input": "Concept: GA (Organic Chemical)", + "output": "Nerve Agents described as an alkylphosphonic acid ester nerve agent that is a colorless or amber liquid with a bitter almond-like fruity odor and is absorbed into the body by inhalation, ingestion, skin contact, or eye contact. GA causes excessive cholinergic stimulation by inhibiting acetylcholinesterase at neuromuscular junctions and in the central nervous system." + }, + { + "input": "Concept: Platinum compounds (Inorganic Chemicals)", + "output": "Platinum-containing Compounds described as inorganic compounds which contain platinum as the central atom." + }, + { + "input": "Concept: long-chain fatty acid transporting porin activity (Molecular Function)", + "output": "Molecular Function described as enables the transfer of long-chain fatty acids from one side of a membrane to the other. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." + }, + { + "input": "Concept: care cmplins edkshn (Therapeutic or Preventive Procedure)", + "output": "Patient counseling education described as teaching a patient techniques to assist him or her in complying with his or her therapy and/or treatment." + }, + { + "input": "Concept: Usual subsequent 30 minutes in-office Native American Healing intake (Health Care Activity)", + "output": "Health Care Activity described as using Native American Healing assessment methods in a usual 30-minute, subsequent, in-office meeting to assess the health status of an existing Native American Healing client to reevaluate and/or develop a Native American Healing treatment plan." + }, + { + "input": "Concept: metanephric capsule development (Organ or Tissue Function)", + "output": "something described as the process whose specific outcome is the progression of the metanephric capsule over time, from its formation to the mature structure. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." + }, + { + "input": "Concept: Complete cystectomy (Complete cystectomy)", + "output": "Bladder therapeutic procedures described as surgery to remove all of the bladder (the organ that holds urine) as well as nearby tissues and organs." + }, + { + "input": "Concept: Phagophores (cellular anatomical entity)", + "output": "something described as a disk-like structure that expands, rounds up into a cup-shaped structure, and eventually closes around its cargo (for example cytoplasmic components) to become an autophagosome or Cvt vesicle." + }, + { + "input": "Concept: claps (Disease or Syndrome)", + "output": "SYPHILIS AND OTHER VENEREAL DISEASES described as a urogenital infection that is caused by Neisseria gonorrhoeae." + }, + { + "input": "Concept: sulphamethoxypyridazine (S [Preparations])", + "output": "something described as a long-acting sulfonamide antibiotic." + }, + { + "input": "Concept: FAEVAL (Evaluator - personnel)", + "output": "something described as a person who determines the significance of a finding about an event or intervention." + }, + { + "input": "Concept: Lip and Oral Cavity Cancer pN2a TNM Finding v8 (Lip and Oral Cavity Cancer pN2 TNM Finding v8)", + "output": "Finding described as lip and oral cavity cancer with metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(+); or a single ipsilateral node larger than 3 cm but not larger than 6 cm in greatest dimension and ENE (-)." + }, + { + "input": "Concept: Esthesioneuroblastomas, Olfactory (Neuroblastoma)", + "output": "Nervous system neoplasms malignant NEC described as a rare neuroectodermal tumor originating from olfactory receptor cells in the nasal cavity or paranasal sinuses. Microscopically, it is characterized by neuroblastic differentiation with occasional formation of rosettes. If the tumor is not resected at an early stage, the prognosis is usually poor." + }, + { + "input": "Concept: labile hypertension (Hypertensive disease)", + "output": "Vascular hypertensive disorders NEC described as phenomenon where BLOOD PRESSURE readings are elevated only when taken in clinical settings." + }, + { + "input": "Concept: Slackia Wade et al. 1999 emend. Nagai et al. 2010 (Coriobacteriaceae)", + "output": "Family Coriobacteriaceae described as a genus of obligate anaerobic, Gram positive, cocci, coccobacilli or short bacilli shaped bacterium assigned to the phylum Actinobacteria and the family Coriobacteriaceae." + }, + { + "input": "Concept: Information Exchange, Health (Health Information Management)", + "output": "Health Care described as the process of sharing patient-level health information through electronic networks among disparate health information systems, primarily to permit immediate access at the point of care." + }, + { + "input": "Concept: CDK4 Gene Amplification (Cell or Molecular Dysfunction)", + "output": "something described as a molecular genetic abnormality indicating the presence of multiple copies of the CDK4 gene." + }, + { + "input": "Concept: Powder for epilesional solution (Biomedical or Dental Material)", + "output": "something described as solid sterile preparation consisting of one or more powders intended to be dissolved in the specified liquid to obtain an epilesional solution." + }, + { + "input": "Concept: caudate nucleus (Nucleus of brain)", + "output": "Nucleus of brain described as a predominantly cellular component of the striatum in the primate. Defined on the basis of Nissl and myelin stains it is more medial than the other component, the putamen. The caudate nucleus encircles the putamen, separated from it by the internal capsule ( Carpenter-1983 ). The caudate nucleus and the putamen are not distinguishable in the rodent. There the myelinated fibers that pass through the striatum to connect the cerebral cortex and subcortical structures do not form an internal capsule but are distributed throughout the striatum. Thus, in the rodent the striatum is often called 'caudoputamen' ( Swanson-2004 ).\\r\\n In the striatopallidal system, the classical striatum, or caudoputamen, is the largest part of the dorsal striatum ( Heimer-1995 ). Functionally it belongs to the cerebral nuclei ( Swanson-2004 )." + }, + { + "input": "Concept: regulation of cation transmembrane transport (regulation of ion transmembrane transport)", + "output": "something described as any process that modulates the frequency, rate or extent of cation transmembrane transport." + }, + { + "input": "Concept: Japanese encephalitis virus (J [Preparations])", + "output": "J [Preparations] described as species of flavivirus, one of the Japanese encephalitis virus group, which is the etiological agent of Japanese encephalitis found in Asia, southeast Asia, and the Indian subcontinent; infects man, birds, pigs and horses; probably transmitted by mosquitos." + }, + { + "input": "Concept: deformity; cheek, congenital (Congenital Abnormality)", + "output": "Abnormality of the midface described as an abnormality of the cheek- one of two bilateral soft tissue facial structures in the region of the face inferior to the eyes and between the nose and the ear. Buccal\" means relating to the cheek. The cheek is part of the midface\" []" + }, + { + "input": "Concept: STK-2 (Amino Acid, Peptide, or Protein)", + "output": "Enzyme described as RAC-beta serine/threonine-protein kinase (479 aa, ~56 kDa) is encoded by the human AKT3 gene. This protein plays a role in protein phosphorylation, signal transduction, mitochondrial biogenesis and the regulation of caspase-dependent apoptosis." + }, + { + "input": "Concept: Nozzle (Device Component or Accessory)", + "output": "something described as a device designed to regulate and direct the flow of a fluid." + }, + { + "input": "Concept: Cervix Adenoid Cystic Carcinoma (Primary adenocarcinoma of cervix uteri)", + "output": "Cervix carcinoma described as a rare highly aggressive uterine cancer, macroscopically appearing as an irregular, slow-growing, non-friable, polypoid mass on the uterine cervix and histologically showing a pseudoglandular or cribriform growth pattern. It presents with vaginal bleeding and discharge and abdominal or pelvic pain. The tumour is highly infiltrative, often associated with vascular, lymphatic and perineural invasion, with subsequent haematogenous spread and early recurrence." + }, + { + "input": "Concept: erbB-1 Genes (Gene or Genome)", + "output": "Gene or Genome described as the proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12." + }, + { + "input": "Concept: FGF18 wt Allele (FGF18 gene)", + "output": "Gene or Genome described as human FGF18 wild-type allele is located in the vicinity of 5q35.1 and is approximately 38 kb in length. This allele, which encodes fibroblast growth factor 18 protein, plays a role in promoting cell proliferation in the small intestine and liver." + }, + { + "input": "Concept: LXR-b agonist RGX-104 (Antineoplastic Agents)", + "output": "something described as an orally bioavailable agonist of the nuclear receptor liver X receptor beta (LXRbeta; NR1H2; LXR-b), with potential immunomodulating and antineoplastic activities. Upon oral administration, LXRbeta agonist RGX-104 selectively targets and binds to LXRbeta, thereby activating LXRbeta-mediated signaling, leading to the transcription of certain tumor suppressor genes and the downregulation of certain tumor promoter genes. This particularly activates the expression of apolipoprotein E (ApoE), a tumor suppressor protein, in tumor cells and certain immune cells. This activates the innate immune system, resulting in depletion of immunosuppressive myeloid-derived suppressor cells (MDSCs), tumor cells and endothelial cells in the tumor microenvironment. This reverses immune evasion, enhances anti-tumor immune responses and inhibits proliferation of tumor cells. LXRbeta, a member of the oxysterol receptor family, which is in the nuclear receptor family of transcription factors, plays a key role in cholesterol transport, glucose metabolism and the modulation of inflammatory responses; activation of LXRbeta suppresses tumor cell invasion, angiogenesis, tumor progression, and metastasis in a variety of tumor cell types. The expression of the ApoE protein becomes silenced in human cancers as they grow, become invasive, and metastasize; ApoE silencing is related to reduced survival in cancer patients. The LXR-ApoE pathway regulates the ability of cancers to evade the immune system and recruit blood vessels." + }, + { + "input": "Concept: mesenchyme (Connective Tissue)", + "output": "something described as mesodermal tissue or tissue with mesodermal origin." + }, + { + "input": "Concept: regulation of protein localization to meiotic spindle pole body (regulation of protein localization to spindle pole body)", + "output": "regulation of protein localization to spindle pole body described as any process that modulates the frequency, rate or extent of protein localization to a meiotic spindle pole body." + }, + { + "input": "Concept: Expansion history reference set (Intellectual Product)", + "output": "Intellectual Product described as a reference set used to record the history of how each expansion reference set was generated." + }, + { + "input": "Concept: RUNX1T1 Protein (Co-Repressor Proteins)", + "output": "Amino Acid, Peptide, or Protein described as a transcriptional co-repressor that contains a MYND-type zinc finger (MYND DOMAIN) at its C-terminal and functions as a homo-oligomer. It associates with DNA-binding transcription factors, other repressor proteins, and HISTONE ACETYLTRANSFERASES to repress expression of genes involved in cell growth and differentiation such as MATRIX METALLOPROTEINASE 7 and TCF12. A CHROMOSOMAL TRANSLOCATION involving the RUNX1T1 and CORE BINDING FACTOR ALPHA 2 SUBUNIT (RUNX1) genes frequently occurs in cells of leukemia patients; the resulting fusion protein (AML1-ETO or RUNX1-RUNX1T1) plays a critical role in leukemogenesis." + }, + { + "input": "Concept: JUNB (JUNB gene)", + "output": "JUNB gene described as human JUNB wild-type allele is located in the vicinity of 19p13.2 and is approximately 2 kb in length. This allele, which encodes transcription factor jun-B protein, plays a role in the modulation of transcription by RNA polymerase II." + }, + { + "input": "Concept: area 32 of Carmichael (medial prefrontal cortex - macaque)", + "output": "Body Location or Region described as part of an alternate segmentation of the anterior cingulate gyrus in the macaque. It is defined on the basis of internal structure in the macaque. It is one of three components of the medial prefrontal cortex (macaque) in the orbitomedial prefrontal cortex (macaque). The other components are area 24 of Carmichael and area 25 (macaque) ( Carmichael-1994 ). It is topologically equivalent to area 32ac in the human, but histologically equivalent to area 32pl ( Ongur-2003 )." + }, + { + "input": "Concept: adipocytokine signaling pathway (Signal Transduction Pathways)", + "output": "something described as increased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin." + }, + { + "input": "Concept: Dinitrocresols (Organic Chemical)", + "output": "Cresols described as derivatives of CRESOLS containing two nitro groups." + }, + { + "input": "Concept: PODCI227 (PODCI Adolescent Parent-Reported Version Questionnaire Question)", + "output": "Intellectual Product described as pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported - How often does your child use assistive devices (such as braces, crutches, or wheelchair) for walking and climbing?" + }, + { + "input": "Concept: Aerobacter, subgroup B (Bacterium)", + "output": "Klebsiella described as gram-negative, capsulated, gas-producing rods found widely in nature. Both motile and non-motile strains exist. The species is closely related to KLEBSIELLA PNEUMONIAE and is frequently associated with nosocomial infections" + }, + { + "input": "Concept: blasticidin-S aminohydrolase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines)", + "output": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines described as catalysis of the reaction: blasticidin S + H2O = deaminohydroxyblasticidin S + NH3." + }, + { + "input": "Concept: APOC3 Gene (Gene or Genome)", + "output": "Transport Protein Gene described as this gene is involved in the regulation of lipoprotein metabolism and transport." + }, + { + "input": "Concept: Bfa1-Bub2 complex (GTPase activator complex)", + "output": "something described as a protein complex that acts as a two-component GTPase-activating protein for Tem1 GTPase, thus regulating a signal transduction cascade, called the mitotic exit network (MEN), which is required for mitotic exit and cytokinesis. Bub2/Bfa1 keeps Tem1 inactive until the spindle is properly oriented, thus inhibiting MEN activation." + }, + { + "input": "Concept: CDISC ADAS-Cog - Concentration/Distractibility (Intellectual Product)", + "output": "something described as alzheimer's Disease Assessment Scale-Cognitive CDISC Version (ADAS-Cog CDISC Version) Ability to concentrate or easily be distracted." + }, + { + "input": "Concept: Borderline Fallopian Tube Serous Tumor/Atypical Proliferative Serous Tumor (Fallopian Tube Serous Neoplasm)", + "output": "Neoplastic Process described as a neoplasm of low malignant potential arising from the fallopian tube. It is characterized by an atypical proliferation of serous-type epithelial cells without evidence of stromal invasion." + }, + { + "input": "Concept: Myeloid/Erythroid Ratio (Laboratory Procedure)", + "output": "Laboratory Procedure described as a relative measurement of myeloid progenitor cells to erythrocyte precursor cells in a biological specimen." + }, + { + "input": "Concept: ADL03-Pastime: Reading (ADCS-ADL MCI Questionnaire Question)", + "output": "ADCS-ADL MCI Questionnaire Question described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, MCI (ADCS-ADL MCI) If yes, check pastimes that apply: reading." + }, + { + "input": "Concept: Eukaryotic Peptide Initiation Factor 1 (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as a eukaryotic initiation factor that binds to 40S ribosomal subunits. Although initially considered a \"non-essential\" factor for eukaryotic transcription initiation, eukaryotic initiation factor-1 is now thought to play an important role in localizing RIBOSOMES at the initiation codon of MRNA." + }, + { + "input": "Concept: Pigtail Drain (Medical Devices)", + "output": "Medical Device described as a hollow tube that has holes in the wall of the tube and a coiled tip and is inserted into a body cavity or organ to promote drainage." + }, + { + "input": "Concept: area 29d of Vogt (Body Location or Region)", + "output": "something described as the more medial of two subdivisions of area 29, which are defined on the basis of cytoarchitecture in the human and the macaque ( Vogt-2012 ). It is located caudally in the posterior cingulate gyrus and the isthmus of the cingulate gyrus between area 29l laterally and area 30 medially ( Vogt-1987 )," + }, + { + "input": "Concept: gas natural (Saturated aliphatic hydrocarbon)", + "output": "Fossil Fuels described as a naturally occurring gas consisting of a hydrocarbon mixture that is primarily methane, but may include varying amounts of other higher alkanes and a small percentage of carbon dioxide, nitrogen, hydrogen sulfide, or helium. Natural gas is a fossil fuel used as a source of energy for heating, cooking, electricity generation, and transportation. It is also used in the manufacture of plastics and other commercially important organic chemicals." + }, + { + "input": "Concept: P450 Enzyme (Enzyme)", + "output": "Enzyme described as a family of cytochromes that are involved in electron transport and oxidative metabolism of drugs and other bioactive molecules. When the catalytic heme is reduced the absorbance peak for this protein occurs at 450 nm." + }, + { + "input": "Concept: clotting time, ecarin (Blood coagulation tests)", + "output": "Laboratory Procedure described as the determination of the activity of thrombin inhibitors in a biological specimen based on the generation of meizothrombin." + }, + { + "input": "Concept: Autosomal recessive intellectual disability due to TRAPPC9 (trafficking protein particle complex 9) deficiency (Intellectual Disability)", + "output": "Multiple malformation syndrome with facial defects as major feature described as a rare syndromic intellectual disability with primary characteristics of moderate to severe intellectual disability, true-to-relative microcephaly and brain abnormalities including a thin corpus callosum, cerebellar hypoplasia, cerebral white matter hypoplasia and multi-focal hyperintensity of cerebral white matter on MRI. Obesity and distinctive craniofacial dysmorphism (including brachycephaly, round face, straight eyebrows, synophrys, hypertelorism, epicanthus, wide and depressed nasal bridge, protruding ears with uplifted lobe, downslanting corners of the mouth) are additional features." + }, + { + "input": "Concept: atypical angina pectoris (Angina Pectoris)", + "output": "Disease or Syndrome described as angina pectoris which does not have associated classical symptoms of chest pain. Symptoms may include weakness, nausea, or sweating." + }, + { + "input": "Concept: Chininum muriaticum / quinine muriate (Pharmacologic Substance)", + "output": "Organic Chemical described as muriate of quinine." + }, + { + "input": "Concept: pT1mic Carcinoma of Breast v6 (Finding)", + "output": "Breast Cancer pT1 TNM Finding v6 and v7 described as breast cancer with tumor size 0.1 cm or less in greatest dimension (microinvasion)." + }, + { + "input": "Concept: Phosphorylated STAT3 (STAT3 Measurement)", + "output": "something described as a measurement of the phosphorylated STAT3 (signal transducer and activator of transcription 3) in a biological specimen." + }, + { + "input": "Concept: Blattella germanica IgG Antibody RAST Score Measurement (Laboratory Procedure)", + "output": "Laboratory Procedure described as a classification of the amount of Blattella germanica antigen IgG antibody present in a sample using the radioallergosorbent test (RAST) scoring system." + }, + { + "input": "Concept: Mean JT Duration (Quantitative Concept)", + "output": "Quantitative Concept described as the average (mean) duration (time) of the JT interval, obtained from a set of measurements of the JT interval. The JT interval is defined as the time from the J point (end of ventricular depolarization, the point at which the QRS meets the ST segment) to the end of the T wave (representing the end of ventricular repolarization)." + }, + { + "input": "Concept: Adrenal Cortical Carcinoma pT3 TNM Finding v8 (Finding)", + "output": "something described as tumor of any size with local invasion but not invading adjacent organs." + }, + { + "input": "Concept: Ekkwill (Fish)", + "output": "Zebrafish described as a wild-type zebrafish line, the stock of which was obtained from Ekkwill Breeders (Florida)." + }, + { + "input": "Concept: Climbing 50 Steps Nonstop (Clinical or Research Assessment Question)", + "output": "Clinical or Research Assessment Question described as a question about an individual's ability to climb 50 steps nonstop." + }, + { + "input": "Concept: vestibulocochlear nerve structural organization (Organ or Tissue Function)", + "output": "Organ or Tissue Function described as the process that contributes to the act of creating the structural organization of the vestibulocochlear nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." + }, + { + "input": "Concept: Have Normal Bowel Pattern (Clinical or Research Assessment Answer)", + "output": "Clinical or Research Assessment Answer described as a response indicating that an individual has or had a normal pattern of bowel movements." + }, + { + "input": "Concept: anterograde dendritic transport of mRNA RNP complex (dendritic transport of messenger ribonucleoprotein complex)", + "output": "dendritic transport of messenger ribonucleoprotein complex described as the directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites towards the postsynapse." + }, + { + "input": "Concept: succinate import into cell (Import into cell)", + "output": "succinate transmembrane transport described as the directed movement of succinate from outside of a cell, across the plasma membrane and into the cytosol." + }, + { + "input": "Concept: EPS8 Like 2 wt Allele (Gene or Genome)", + "output": "Gene or Genome described as human EPS8L2 wild-type allele is located in the vicinity of 11p15.5 and is approximately 22 kb in length. This allele, which encodes epidermal growth factor receptor kinase substrate 8-like protein 2, plays a role in signal transduction related to actin remodeling." + }, + { + "input": "Concept: parturition (Surgical Manipulation)", + "output": "Obstetric action described as delivery of the FETUS and PLACENTA under the care of an obstetrician or a health worker. Obstetric deliveries may involve physical, psychological, medical, or surgical interventions." + }, + { + "input": "Concept: Perinatal Aspiration of Blood (Syndrome)", + "output": "Disease or Syndrome described as respiratory distress in the newborn due to inhalation of blood; this is an unusual event and is sometimes linked to the non passage of meconium before delivery or mothers with antepartum hemorrhage." + }, + { + "input": "Concept: inhibitory chemical synaptic transmission (chemical synaptic transmission)", + "output": "Cell Function described as synaptic transmission that results in an inhibitory postsynaptic potential." + }, + { + "input": "Concept: ELECTROCARDIOGRAPH,AMBULATORY(WITHOUT ANALYSIS) (Medical Device)", + "output": "Medical Device described as a medical magnetic tape recorder is a device used to record and play back signals from, for example, physiological amplifiers, signal conditioners, or computers." + }, + { + "input": "Concept: Abnormality of the calf (Deformity of lower limb)", + "output": "something described as an abnormality of the calf, i.e. of the posterior part of the lower leg." + }, + { + "input": "Concept: Overlay (Device Component or Accessory)", + "output": "Device Component or Accessory described as a device designed to be applied over an object, typically for protection or identification." + }, + { + "input": "Concept: Glucose measurement (biochemical test)", + "output": "Measurement of substance described as the determination of the amount of glucose present in a sample." + }, + { + "input": "Concept: Axillary Neoplasm (Neoplastic Process)", + "output": "Neoplastic Process described as a benign or malignant neoplasm that affects the structures of the axilla. Representative examples include axillary lipoma, axillary lymph node lymphoma, and metastatic carcinoma to the axillary lymph nodes." + }, + { + "input": "Concept: overbreathing (Symptomatology)", + "output": "ventilatory functions described as hyperventilation refers to an increased pulmonary ventilation rate that is faster than necessary for the exchange of gases. Hyperventilation can result from increased frequency of breathing, an increased tidal volume, or both, and leads to an excess intake of oxygen and the blowing off of carbon dioxide." + }, + { + "input": "Concept: TEST,IMMUNOASSAY,BIOSENSOR,HCG (Medical Device)", + "output": "something described as (a) Human chorionic gonadotropin (HCG) test system intended for the early detection of pregnancy--A human chorionic gonadotropin (HCG) test system intended for the early detection of pregnancy is a device intended for the early detection of pregnancy is intended to measure HCG, a placental hormone, in plasma or urine. (b) Human chorionic gonadotropin (HCG) test system intended for any uses other than early detection of pregnancy--A human chorionic goadotropin (HCG) test system is a device intended for any uses other than early detection of pregnancy (such as an aid in the diagnosis, prognosis, and management of treatment of persons with certain tumors or carcinomas) is intended to measure HCG, a placental hormone, in plasma or urine." + }, + { + "input": "Concept: N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1- dicarboxamide (Chemical categorised functionally)", + "output": "VEGFR Tyrosine Kinase Inhibitor described as an orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Cabozantinib strongly binds to and inhibits several RTKs, which are often overexpressed in a variety of cancer cell types, including hepatocyte growth factor receptor (MET), RET (rearranged during transfection), vascular endothelial growth factor receptor types 1 (VEGFR-1), 2 (VEGFR-2), and 3 (VEGFR-3), mast/stem cell growth factor (KIT), FMS-like tyrosine kinase 3 (FLT-3), TIE-2 (TEK tyrosine kinase, endothelial), tropomyosin-related kinase B (TRKB) and AXL. This may result in an inhibition of both tumor growth and angiogenesis, and eventually lead to tumor regression." + }, + { + "input": "Concept: Teacher Form Questionnaire (Research or Clinical Assessment Tool)", + "output": "Research or Clinical Assessment Tool described as a questionnaire included in the Behavior Rating Inventory of Executive Function. The teacher form is completed by any adult with extended contact with the child in an academic setting, typically a teacher, but an aide is acceptable. The adult must have at least 1 month familiarity with the child." + }, + { + "input": "Concept: Mild global developmental delay (Central Nervous System)", + "output": "Central Nervous System described as a mild delay in the achievement of motor or mental milestones in the domains of development of a child." + }, + { + "input": "Concept: PASI Clinical Classification Question (Intellectual Product)", + "output": "Intellectual Product described as a question associated with the PASI clinical classification." + }, + { + "input": "Concept: Grade 3 Lordosis (Finding)", + "output": "Lordosis, CTCAE described as severe accentuation; operative intervention indicated; limiting self care ADL" + }, + { + "input": "Concept: papillary necrosis due to diabetes mellitus (Diabetic Nephropathy)", + "output": "Complications of Diabetes Mellitus described as renal papillary necrosis in a patient with type 1 or type 2 diabetes." + }, + { + "input": "Concept: Extremity Hand Positioning (Intellectual Product)", + "output": "Clinical or Research Assessment Question described as a question about the range of movement of a person's upper extremity." + }, + { + "input": "Concept: CAMPYLOBACTER UREOLYTICUS (Bacteroides)", + "output": "Bacteroides described as any bacterial organism that can be assigned to the species Campylobacter ureolyticus." + }, + { + "input": "Concept: snoRNA processing (ncRNA processing)", + "output": "something described as any process involved in the conversion of a primary small nucleolar RNA (snoRNA) transcript into a mature snoRNA." + }, + { + "input": "Concept: toxin (GENERAL CONVENIENCE CODES)", + "output": "Substance categorized by disposition described as specific, characterizable, poisonous chemicals, often PROTEINS, with specific biological properties, including immunogenicity, produced by microbes, higher plants (PLANTS, TOXIC), or ANIMALS." + }, + { + "input": "Concept: discriminant analysis (Research Activity)", + "output": "Statistical Technique described as a statistical technique used to determine which variables discriminate between two or more naturally groups and to determine whether groups differ with regard to the mean of a variable." + }, + { + "input": "Concept: Childhood Laryngeal Carcinoma (Neoplastic Process)", + "output": "Neoplastic Process described as a rare carcinoma of the larynx that occurs during childhood." + }, + { + "input": "Concept: Trouble remembering more than one thing at a time (Intellectual Product)", + "output": "Clinical or Research Assessment Question described as a question about whether an individual has or had trouble remembering more than one thing at a time." + }, + { + "input": "Concept: spondyloepiphyseal dysplasias (Skeletal dysplasia)", + "output": "Skeletal described as a disorder of bone growth affecting the vertebrae and the ends of the long bones (epiphyses)." + }, + { + "input": "Concept: Dialysis Disequilibrium Syndrome (Acute disorder of hemodialysis)", + "output": "Disease or Syndrome described as a complication occurring during hemodialysis that is thought to be due to a rapid decrease in blood urea nitrogen, and is characterized by an increase in intracranial pressure resulting in nausea, headache, vomiting, restlessness, and/or a decreased level of consciousness." + }, + { + "input": "Concept: Microspectrophotometries (Spectrophotometry)", + "output": "something described as examination of and comparing photometrically the relative intensities of the light in the spectra of microscopic objects." + }, + { + "input": "Concept: Welding (Metallurgy)", + "output": "something described as joining metal pieces or parts together by melting the adjoining surfaces with heat, using a heat source such as a blowtorch or electric arc. The melted surfaces are then pressed together by hammering." + }, + { + "input": "Concept: fluorine F 18 sodium fluoride (Pharmacologic Substance)", + "output": "something described as a radiopharmaceutical consisting of the sodium salt of fluorine F 18 fluoride with radioisotopic and bone mineralizing activities. Fluoride binds to calcium ions in hydroxyapatite crystals in bone. The uptake and incorporation of positron-emitting fluorine F 18 fluoride into bone can be imaged using positron emission tomography (PET) or single-photon emission computed tomography (SPECT), allowing visualization of malignant bone lesions in which regional blood flow and bone turnover are increased." + }, + { + "input": "Concept: upregulation of austinol biosynthetic process (Molecular Function)", + "output": "Molecular Function described as any process that activates or increases the frequency, rate or extent of austinol biosynthetic process." + }, + { + "input": "Concept: galago (Galagonidae)", + "output": "something described as a genus of the family Lorisidae having four species which inhabit the forests and bush regions of Africa south of the Sahara and some nearby islands. The four species are G. alleni, G. crassicaudatus, G. demidovii, and G. senegalensis. There is another genus, Euoticus, containing two species which some authors have included in the Galago genus." + }, + { + "input": "Concept: expectorant agents (Cough AND/OR decongestant agent)", + "output": "Agent Affecting Respiratory System described as any agent that promotes ejection of mucus or exudate from the lungs, bronchi and trachea by decreasing mucus viscosity or by increasing the secretion of mucus in a dry, unproductive cough." + }, + { + "input": "Concept: Raynauds' phen (Peripheral vasoconstriction, necrosis and vascular insufficiency)", + "output": "Peripheral vasoconstriction, necrosis and vascular insufficiency described as an episodic vasoconstriction resulting in discoloration of the skin and pain in the affected areas, often involving fingers or toes. Classically associated with triphasic color changes (white, blue, red) but may be biphasic. Often occurs in response to cold temperatures or emotional stress. May be primary or secondary to an underlying autoimmune disease." + }, + { + "input": "Concept: EGG YOLK (Food)", + "output": "Cleidoic ovum described as cytoplasm stored in an egg that contains nutritional reserves for the developing embryo; it is rich in polysaccharides, lipids, and proteins." + }, + { + "input": "Concept: Salmonella enterica and/or Salmonella bongori DNA Measurement (Deoxyribonucleic Acid Measurement)", + "output": "Deoxyribonucleic Acid Measurement described as the determination of the amount of Salmonella enterica and/or Salmonella bongori DNA present in a sample." + }, + { + "input": "Concept: Addition (Functional Concept)", + "output": "Instruction Imperative described as to join or unite with others so as to increase size, quantity, or scope." + }, + { + "input": "Concept: lipopolysaccharide N-acetylmannosaminouronosyltransferase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the reaction: lipopolysaccharide + UDP-N-acetylmannosaminouronate = N-acetyl-beta-D-mannosaminouronosyl-1,4-lipopolysaccharide + UDP." + }, + { + "input": "Concept: Catheters, Vascular, Blood Gas/pH Monitoring (Vascular Catheters)", + "output": "Medical Device described as vascular catheters designed for continuous in vivo measurement of arterial blood gases and pH without removing blood. These catheters include an optical fiber that conducts light and interacts with the indicator (either is absorbed, reflected, or causes fluorescence); the magnitude of the change in the light characteristics depends on the concentration in the blood of the substance being measured. Blood-gas/pH-monitoring catheters use a detector that combines an optical fiber with a fluorescent dye; the detector may be used either on the distal tip of the catheter as an intraarterial gas monitor or as an extraarterial system within a sensor cassette that is inserted in series with the arterial catheter tubing, usually near the patient's wrist. Three detectors are needed for pH, PO2, and PCO2 measurements. These catheters may be used for continuous arterial monitoring of blood gases and pH to improve management and treatment in critically ill patients." + }, + { + "input": "Concept: Device Exemption, Humanitarian (Premarket Approval Application)", + "output": "Premarket Approval Application described as a premarket submission to FDA for a device intended to benefit patients by treating or diagnosing a condition affecting fewer than 4,000 individuals in the United States per year. An HDE is similar in form and content to a premarket approval (PMA) but is exempt from the effectiveness requirements of a PMA." + }, + { + "input": "Concept: PODCI252 (PODCI Adolescent Parent-Reported Version Questionnaire Question)", + "output": "PODCI Adolescent Parent-Reported Version Questionnaire Question described as pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported - Can your child participate in competitive level sports with other children the same age (For example: hockey, basketball, soccer, football, baseball, swimming, running [track or cross country], gymnastics, or dance)?" + }, + { + "input": "Concept: CPTAC Neoplasms Codelist (CPTAC Codelists Terminology)", + "output": "CPTAC Codelists Terminology described as terminology used in support of the data collection efforts of the Clinical Proteomic Tumor Analysis Consortium (CPTAC) with the focus on neoplasms." + }, + { + "input": "Concept: Number of miscarriages or induced terminations of pregnancy (Finding)", + "output": "something described as a measurement of the total number of instances in which there has been a spontaneous termination of pregnancy (miscarriage) or elective termination of pregnancy." + }, + { + "input": "Concept: Healthcare worker (Miscellaneous Occupation)", + "output": "something described as a person qualified to be engaged in activity directed at preservation of mental and physical health by diseases prevention and treatment as a source of livelihood." + }, + { + "input": "Concept: Mitogen-Activated Protein Kinase Kinase 1 (Amino Acid, Peptide, or Protein)", + "output": "Enzyme described as an abundant 43-kDa mitogen-activated protein kinase kinase subtype with specificity for MITOGEN-ACTIVATED PROTEIN KINASE 1 and MITOGEN-ACTIVATED PROTEIN KINASE 3." + }, + { + "input": "Concept: Cripto-1 (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as teratocarcinoma-derived growth factor 1 (188 aa, ~21 kDa) is encoded by the human TDGF1 gene. This protein plays a role in growth factor signaling pathways mediated by Nodal homolog." + }, + { + "input": "Concept: Guaiacum / lignum vitae resin (Organic Chemical)", + "output": "something described as resin of lignum vitae." + }, + { + "input": "Concept: carboxyltransferase/carbamoyltransferase (Enzyme)", + "output": "Amino Acid, Peptide, or Protein described as a group of enzymes that catalyze the transfer of carboxyl- or carbamoyl- groups. EC 2.1.3." + }, + { + "input": "Concept: Abnormal greater sciatic notch morphology (Anatomical Abnormality)", + "output": "Anatomical Abnormality described as an abnormality of the sacrosciatic notch, i.e., the deep indentation in the posterior border of the hip bone at the point of union of the ilium and ischium." + }, + { + "input": "Concept: FACTX (Blood coagulation tests)", + "output": "Laboratory Procedure described as the determination of the amount of factor X present in a sample." + }, + { + "input": "Concept: Cardiovascular System Findings End Day (Observation End Day)", + "output": "Observation End Day described as the final day of the cardiovascular system assessment." + }, + { + "input": "Concept: Gastric Cancer Pathologic Regional Lymph Nodes TNM Finding v7 (Finding)", + "output": "something described as a pathologic finding about one or more characteristics of gastric cancer, following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes." + }, + { + "input": "Concept: Infection due to Neisseria gonorrhoeae (Male Reproductive System)", + "output": "Sexually Transmitted Diseases, Bacterial described as acute infectious disease characterized by primary invasion of the urogenital tract; the etiologic agent is Neisseria gonorrhoeae." + }, + { + "input": "Concept: Upper respiratory symptoms due to Influenza (Viral upper respiratory tract infection)", + "output": "Influenza described as upper respiratory tract infection symptoms include: laryngitis, pharyngitis, nasal congestion, rhinorrhoea, sneezing and coryza." + }, + { + "input": "Concept: Bacteriophages, Staphylococcal (Bacteriophages)", + "output": "Bacteriophages described as viruses whose host is Staphylococcus." + }, + { + "input": "Concept: Pemetrexed-Cisplatin Regimen (Regimen Used to Treat Malignant Mesothelioma)", + "output": "Regimen Used to Treat Malignant Mesothelioma described as a regimen consisting of pemetrexed and cisplatin used for the treatment of malignant mesothelioma." + }, + { + "input": "Concept: Cefixime (C [Preparations])", + "output": "Beta-lactam, Cephalosporins described as a broad-spectrum, third-generation cephalosporin antibiotic derived semisynthetically from the marine fungus Cephalosporium acremonium with antibacterial activity. As does penicillin, the beta-lactam antibiotic cefixime inhibits bacterial cell wall synthesis by disrupting peptidoglycan synthesis, resulting in a reduction in bacterial cell wall stability and bacterial cell lysis. Stable in the presence of a variety of beta-lactamases, this agent is more active against gram-negative bacteria and less active against gram-positive bacteria compared to second-generation cephalosporins. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1100\" active clinical trials using this agent." + }, + { + "input": "Concept: TIC Vapor Filters (Filters, Air, Gas/Vapor)", + "output": "Medical Device described as gas/vapor air filters designed to remove toxic industrial contaminants (TIC's) from the air stream. These filters use gas sorbents according to the expected contaminants and the prevalent conditions (e.g., contaminant concentration, molecular weight and size, temperature); typically activated carbon, zeolites, alumina, or polymer sorbents are used. TIC chemical agent gas/vapor filters are used in air cleaning systems designed for permanent facilities and/or temporary emergency shelters during industrial accidents." + }, + { + "input": "Concept: Gastric node (Lymph node group)", + "output": "Set of visceral abdominal lymph nodes described as a lymph node along the left gastric artery or greater omentum." + }, + { + "input": "Concept: UDHR1-Confusion Altered Performance (UHDRS 1999 Version Clinical Classification Question)", + "output": "UHDRS 1999 Version Clinical Classification Question described as unified Huntington's Disease Rating Scale 1999 Version (UHDRS 1999 Version) If yes: Does the examiner believe that this has altered the performance on the UHDRS?" + }, + { + "input": "Concept: Endonuclease III-Like Protein 1 (Enzyme)", + "output": "Amino Acid, Peptide, or Protein described as endonuclease III-like protein 1 (312 aa, ~34 kDa) is encoded by the human NTHL1 gene. This protein plays a role in nucleotide-excision repair." + }, + { + "input": "Concept: Right Reduction Mammoplasty (reconstruction of right breast)", + "output": "Reduction mammaplasty described as surgery performed to reduce the size of the right breast." + }, + { + "input": "Concept: Grade 1 Pleural effusion (Finding)", + "output": "something described as asymptomatic; clinical or diagnostic observations only; intervention not indicated" + }, + { + "input": "Concept: beta-sitosterol UDP-glucosyltransferase activity (Molecular Function)", + "output": "sterol glucosyltransferase activity described as catalysis of the reaction: UDP-glucose + a beta-sitosterol = UDP + O-glucosyl-beta-sitosterol." + }, + { + "input": "Concept: anti-PR1/HLA-A2 monoclonal antibody Hu8F4 (Amino Acid, Peptide, or Protein)", + "output": "Immunologic Factor described as a T-cell receptor (TCR)-like monoclonal antibody against PR1, a 9 amino-acid (VLQELNVTV) human leukocyte antigen (HLA)-A2-restricted leukemia-associated antigen (LAA) derived from the myeloid leukemia-associated antigens proteinase 3 (P3) and neutrophil elastase (NE), with potential immunostimulating and antineoplastic activities. Upon administration, anti-PR1/HLA-A2 monoclonal antibody Hu8F4 selectively binds to a combined epitope of the PR1/HLA-A2 complex expressed on acute myeloid leukemia (AML) blasts and leukemic stem cells (LSC), and prevents PR1/HLA-A2-mediated signaling. This induces complement-dependent cytotoxicity (CDC), to a lesser extent, antibody-dependent cell-mediated cytotoxicity (ADCC), and CDC/ADCC-independent cytolysis of myeloid leukemia cells. This results in a reduction of cellular proliferation in PR1/HLA-A2-overexpressing leukemic cells. PR1 in combination with the HLA-A2 molecule is highly expressed on AML blasts and LSCs. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C123924\" active clinical trials using this agent." + }, + { + "input": "Concept: SEN (Geographic Area)", + "output": "something described as a country in western Africa, bordering the North Atlantic Ocean, between Guinea-Bissau and Mauritania." + }, + { + "input": "Concept: Star of Bethlehem (Ornithogaloideae)", + "output": "Plant described as a plant genus of the family LILIACEAE that contains cholestane glycosides (CHOLESTANES)." + }, + { + "input": "Concept: Shared care prescribing of drug for dementia (Finding)", + "output": "Shared care prescribing described as drugs for dementia can be initiated by a specialist but continued to be prescribed by a general practitioner/primary care physician under a shared care prescribing arrangement." + }, + { + "input": "Concept: Type II Hemipelvectomy (Therapeutic or Preventive Procedure)", + "output": "something described as a hemipelvectomy with the resection confined to the periacetabulum." + }, + { + "input": "Concept: Scheduled Activity Date Range (Date Range)", + "output": "something described as the date and time span specifying when the activity is scheduled to begin and end." + }, + { + "input": "Concept: 2-aminoethylphosphonate transmembrane transporter activity (active transmembrane transporter activity)", + "output": "Molecular Function described as enables the directed movement of 2-aminoethylphosphonate from one side of a membrane to the other." + }, + { + "input": "Concept: MALTODEXTRIN (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as an oligosaccharide derived from starch that is used as a food additive and as a carbohydrate supplement. As a supplement, maltodextrin is used to provide and sustain energy levels during endurance-oriented workouts or sports, to help build muscle mass and support weight gain. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C68474\" active clinical trials using this agent." + }, + { + "input": "Concept: LNK (SH2B3 gene)", + "output": "Gene or Genome described as human SH2B3 wild-type allele is located in the vicinity of 12q24 and is approximately 46 kb in length. This allele, which encodes SH2B adapter protein 3, is involved in signal transduction. Mutation of the gene is associated with susceptibility to both celiac disease type 13 and insulin-dependent diabetes mellitus." + }, + { + "input": "Concept: Nafarelin acetate preparation (Amino Acid, Peptide, or Protein)", + "output": "something described as the acetate salt form of nafarelin, a modified synthetic porcine luteinizing hormone (LH)-releasing hormone peptide analog, with gonadotropin-releasing hormone (GnRH) agonist activity. Upon nasal inhalation, nafarelin acetate binds to the GnRH receptor. This initially results in the release of the gonadotropins, follicle-stimulating hormone (FSH) and LH, from the pituitary gland; however, prolonged stimulation of the GnRH receptor desensitizes the receptor, which leads to decreased secretion of FSH and LH. In females, the inhibition of gonadotropin secretion causes hypogonadotropic hypogonadism leading to decreased production of estrogen and progesterone and anovulation. In males, the inhibition of LH secretion prevents the production and release of testosterone from Leydig cells in the testes and causes a significant decline in testosterone production that is near the levels seen following castration." + }, + { + "input": "Concept: HBQ1 wt Allele (HBQ1 gene)", + "output": "Gene or Genome described as human HBQ1 wt allele is located in the vicinity of 16p13.3 and is approximately 1 kb in length. This allele, which encodes hemoglobin subunit theta-1 protein, may play a role in the transport of oxygen to embryonic tissues." + }, + { + "input": "Concept: cognitive intervention (Behavioral, Psychological or Informational Intervention)", + "output": "Health Care Activity described as a set of therapy techniques derived from the school of cognitive psychology, which the practitioner uses to conduct therapy." + }, + { + "input": "Concept: mRNA cleavage stimulating factor complex location (mRNA cleavage factor complex)", + "output": "Cell Component described as a protein complex required for mRNA cleavage but not for poly(A) addition." + }, + { + "input": "Concept: Abnormality of the glenoid fossa (Anatomical Abnormality)", + "output": "something described as an anomaly of the glenoid fossa, also known as the glenoid cavity, which is the articular surface of the scapula that articulates with the head of the humerus." + }, + { + "input": "Concept: up regulation of chaperone-mediated protein folding (Molecular Function)", + "output": "regulation of chaperone-mediated protein folding described as any process that activates or increases the frequency, rate or extent of chaperone-mediated protein folding." + }, + { + "input": "Concept: Catheters, Vascular, Angioplasty, Ultrasound Ablation (Angioplasty catheter)", + "output": "Angioplasty catheter described as angioplasty catheters that use ultrasonic energy for ablation of atheroma. These catheters typically consist of a multilumen 7 to 9 Fr tube that includes a 1.5 to 2.6 Fr solid-wire ball-tipped probe with an ultrasonic transducer at its proximal tip and an irrigation channel to cool the ultrasound probe. Ultrasonic angioplasty catheters may be used to open total occlusions or high-grade stenosis in arteries, including calcified arteries; they may also be used to facilitate balloon angioplasty." + }, + { + "input": "Concept: Mixed Malignant Epithelial Cell Population (Finding)", + "output": "something described as a morphologic finding indicating the presence of a mixed population of malignant epithelial cells in a tumor sample." + }, + { + "input": "Concept: Refractory Myxoid/Round Cell Liposarcoma (Refractory Liposarcoma)", + "output": "Neoplastic Process described as myxoid liposarcoma that does not respond to treatment." + }, + { + "input": "Concept: BiCNU Regimen (Regimen Used to Treat Central Nervous System Neoplasm)", + "output": "Regimen Used to Treat Central Nervous System Neoplasm described as a chemotherapy regimen consisting of carmustine that may be used in the treatment of anaplastic gliomas and glioblastomas; adult low-grade infiltrative supratentorial astrocytoma/oligodendroglioma (excluding pilocytic astrocytoma); and adult intracranial and spinal ependymomas (excluding subependymomas and myxopapillary ependymomas)." + }, + { + "input": "Concept: DIHYDROSTREPTOMYCIN (Antibiotics, Aminoglycoside)", + "output": "Antibiotics, ophthalmologic described as a derivative of streptomycin, aminoglycoside antibiotic, with bactericidal property. Dihydrostreptomycin depends on active transport across the bacterial cell membrane before irreversibly binding S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the initiation complex between messenger RNA and the bacterial ribosome thereby causing the misreading of the genetic code resulting in the production of non-functional proteins, consequently leading to bacterial cell death." + }, + { + "input": "Concept: Cancer antigen 27.29 (Laboratory Procedure)", + "output": "Tumor antigen measurement described as the determination of the amount of cancer antigen 27-29 present in a sample." + }, + { + "input": "Concept: Bilateral ulnar hypoplasia (Finding)", + "output": "Finding described as underdevelopment of the ulna on both sides." + }, + { + "input": "Concept: Abnormality of T cell physiology (Abnormal lymphocyte physiology)", + "output": "Abnormal lymphocyte physiology described as a functional anomaly of T cells." + }, + { + "input": "Concept: long descending thin limb bend development (tube development)", + "output": "something described as the process whose specific outcome is the progression of the long descending thin limb bend over time, from its formation to the mature structure. The long descending thin limb bend is a part of the descending thin limb of a long nephron that lies beyond the prebend segment." + }, + { + "input": "Concept: positive regulation of interleukin-37 biosynthetic process (Cell Function)", + "output": "positive regulation of cytokine biosynthetic process described as any process that activates or increases the frequency, rate or extent of interleukin-37 biosynthetic process." + }, + { + "input": "Concept: Stage 0 Lung Adenocarcinoma AJCC v6 (Adenocarcinoma in Situ)", + "output": "Adenocarcinoma in Situ described as stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis." + }, + { + "input": "Concept: GWN323 (Amino Acid, Peptide, or Protein)", + "output": "Immunologic Factor described as an anti-human glucocorticoid-induced tumor necrosis factor receptor (tumor necrosis factor superfamily, member 18; TNFRSF18; GITR; CD357) agonistic monoclonal antibody, with potential immune checkpoint modulating activity. Anti-GITR antibody GWN 323 binds to and activates GITRs found on multiple types of T-cells. This stimulates the immune system, induces both the activation and proliferation of tumor-antigen-specific T effector cells (Teff), and suppresses the function of activated T regulatory cells (Tregs). This leads to tumor cell eradication. GITR, a member of the TNF receptor superfamily and T-cell receptor co-stimulator, is expressed on the surface of multiple immune cell types, including Tregs, Teffs, B-cells, and natural killer (NK) cells. Inappropriately activated Tregs suppress both Teffs and T-cell receptor (TCR) signaling." + }, + { + "input": "Concept: CENPA Gene (Gene or Genome)", + "output": "something described as this gene plays a role in kinetochore assembly and cell cycle progression." + }, + { + "input": "Concept: Histiocytic Sarcomas (Sarcoma)", + "output": "MISCELLANEOUS TUMORS described as an aggressive malignant neoplasm with a poor response to therapy, usually presenting as stage III/IV disease. It is characterized by the presence of neoplastic cells with morphologic and immunophenotypic characteristics similar to those seen in mature histiocytes. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C27349\" active clinical trials using this agent." + }, + { + "input": "Concept: INDC (HL7 Vocabulary Version 2.5)", + "output": "HL7 Vocabulary Version 2.5 described as a general description of the disease or condition the product will diagnose, treat, prevent, cure, or mitigate." + }, + { + "input": "Concept: NIDR (Component of the National Institutes of Health)", + "output": "Component of the National Institutes of Health described as one of the institutes that comprise the National Institutes of Health. The mission of the NIDCR is to improve oral, dental and craniofacial health through research, research training, and the dissemination of health information." + }, + { + "input": "Concept: Individual attitudes of extended family members (CHAPTER 4 ATTITUDES)", + "output": "Individual Behavior described as general or specific opinions and beliefs of extended family members about the person or about other matters (e.g. social, political and economic issues), that influence individual behaviour and actions." + }, + { + "input": "Concept: Head structure (Radiology studies)", + "output": "Head and neck structure described as the upper part of the human body, or the front or upper part of the body of an animal, typically separated from the rest of the body by a neck, and containing the brain, mouth, and sense organs." + }, + { + "input": "Concept: 1-(4-((6-Amino-5-(4-phenoxy-phenyl)-pyrimidin-4-ylamino)-methyl)-piperidin-1-yl)-propenone (BTK Inhibitor)", + "output": "Organic Chemical described as an inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, evobrutinib inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways, which leads to the inhibition of the growth of malignant B-cells that overexpress BTK. BTK, a member of the Src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B-lymphocyte development, activation, signaling, proliferation and survival." + }, + { + "input": "Concept: Placentation, function (Female reproductive function)", + "output": "Pregnancy described as the development of the PLACENTA, a highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products between mother and FETUS. The process begins at FERTILIZATION, through the development of CYTOTROPHOBLASTS and SYNCYTIOTROPHOBLASTS, the formation of CHORIONIC VILLI, to the progressive increase in BLOOD VESSELS to support the growing fetus." + }, + { + "input": "Concept: Camptodactyly of the third finger (Flexion contracture of proximal interphalangeal joint of finger)", + "output": "Flexion contracture of proximal interphalangeal joint of finger described as chronic loss of joint motion of the proximal interphalangeal joint of the 3rd finger due to structural changes in non-bony tissue." + }, + { + "input": "Concept: Congenital chronic diarrhoea with exudative enteropathy (Congenital Disorders)", + "output": "Autosomal recessive hereditary disorder described as a rare genetic intestinal disease characterised by early-onset chronic non-infectious, non-bloody, watery diarrhoea associated with protein-losing enteropathy, which results in hypoalbuminaemia, hypogammaglobulinaemia and elevated stool alpha-1-antitrypsin. Patients typically present severe, intractable diarrhoea, failure to thrive, recurrent infections and oedema. There is evidence the disease is caused by homozygous mutation in the DGAT1 gene." + }, + { + "input": "Concept: Bone-in-Bone Sign (Finding)", + "output": "Radiologic finding described as a radiologic finding that is seen in osteopetrosis. It is characterized by an increased sclerosis in the superior and inferior aspects of the midbody of the vertebra, resulting in the image of a duplicate vertebral body inside the normal one." + }, + { + "input": "Concept: EPIC-CP - Lack of Energy (EPIC-CP Questionnaire Question)", + "output": "Intellectual Product described as expanded Prostate Cancer Index Composite for Clinical Practice - How big a problem, if any, has each of the following been for you? Lack of energy." + }, + { + "input": "Concept: Pharmacy Service Providers; Technician; Pharmacy (Professional or Occupational Group)", + "output": "Technical healthcare occupation described as persons who perform certain functions under the supervision of a pharmacist." + }, + { + "input": "Concept: VFQ2-Difficulty Reading Small Print (Intellectual Product)", + "output": "something described as national Eye Institute Visual Functioning Questionnaire - 25 Version 2000 Self-Administered Format - Near Vision: Wearing glasses, how much difficulty do you have reading the small print in a telephone book, on a medicine bottle, or on legal forms? Would you say:" + }, + { + "input": "Concept: CT of neck, chest, abdomen and pelvis without contrast (Diagnostic Procedure)", + "output": "something described as computed tomography of the neck, chest, abdomen and pelvis without the use of a contrast agent." + }, + { + "input": "Concept: Phototherapy/Surgical Systems, Laser/LED (Medical Device)", + "output": "something described as systems that combine lasers, lamps, and light emitting diode (LEDs) units and are designed to provide surgical and phototherapy treatments. These systems usually consist of: (1) a central unit (console) that includes the power supply, controls, and switches for the operation of the system; (2) several units intended to deliver the independent or combined treatments (e.g., lamps, LEDs, and Nd:YAG, Er:YAG Lasers); and (3) dedicated handpieces used to deliver energy from particular units to the patient. The combined system is intended for general and plastic surgery and also for a variety of dermatologic treatments such as benign vascular lesions, psoriasis, vitiligo, eczema, warts, and scars; they are also used for hair and tattoo removal." + }, + { + "input": "Concept: Hypopharyngeal Cancer pT4a TNM Finding v7 (Finding)", + "output": "something described as hypopharyngeal cancer with moderately advanced local disease. Tumor invades the thyroid/cricoid cartilage, hyoid bone, thyroid gland, or central compartment soft tissue. Central compartment soft tissue includes prelaryngeal strap muscles and subcutaneous fat." + }, + { + "input": "Concept: Structure of articular pillar of cervical vertebra (Cervical Vertebrae)", + "output": "Body Part, Organ, or Organ Component described as the columnar arrangement of the articular portions of the cervical vertebrae that contain a superior and inferior articular facet." + }, + { + "input": "Concept: Meconium staining of amniotic fluid (Amniotic fluid appearance - finding)", + "output": "Amniotic fluid and cavity disorders of pregnancy NEC described as presence of meconium into amniotic fluid." + }, + { + "input": "Concept: regulation of late stripe melanocyte differentiation (Cell Function)", + "output": "something described as any process that modulates the frequency, rate or extent of late stripe melanocyte differentiation." + }, + { + "input": "Concept: Raoultella (Enterobacteriaceae)", + "output": "something described as a genus of aerobic, Gram negative, rod shaped bacterium assigned to the phylum Proteobacteria and the family Enterobacteriaceae." + }, + { + "input": "Concept: communities education health (Educational process of instructing)", + "output": "something described as draws on social relationships and organizations to reach large populations through media and interpersonal strategies that deliver messages and mechanisms to reduce chronic diseases." + }, + { + "input": "Concept: 4-acetamidobutyryl-CoA deacetylase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)", + "output": "deacetylase activity described as catalysis of the reaction: 4-acetamidobutanoyl-CoA + H(2)O = 4-aminobutanoyl-CoA + acetate." + }, + { + "input": "Concept: G1/S-Specific Cyclin D3 Protein Variant (Gene Product Sequence Variation)", + "output": "something described as a variation in the amino acid sequence for the G1/S-specific cyclin-D3 protein." + }, + { + "input": "Concept: hydroxyketoglutaric aldolase activity (oxo-acid-lyase activity)", + "output": "oxo-acid-lyase activity described as catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate." + }, + { + "input": "Concept: Stage IV Anal Canal and Perianal (Anal Margin) Carcinoma AJCC v8 (Anal Cancer by AJCC v8 Stage)", + "output": "something described as stage IV includes: Any T, Any N, M1. M1: Distant metastasis." + }, + { + "input": "Concept: Tetracosahexaenoic Acid (Polyunsaturated Fatty Acids)", + "output": "Polyunsaturated Fatty Acids described as a polyunsaturated fatty acid with a 24-carbon backbone and six double bonds. Three stereoisomers of Tetracosahexaenoic acid are recognized." + }, + { + "input": "Concept: DDS02-Healthcare Team Distress: Sum (PARENT-DDS Questionnaire Question)", + "output": "Intellectual Product described as diabetes Distress Scale for Parents of Teens with Type 1 Diabetes (PARENT-DDS) Healthcare team distress: Sum of 2 items (11, 16)." + }, + { + "input": "Concept: Weakness of muscles of respiration (Finding)", + "output": "Muscle Weakness described as reduced function of the muscles required to generate subatmospheric pressure in the thoracic cavity during breathing: the diaphragm, the external intercostal and the interchondral part of the internal intercostal muscles." + }, + { + "input": "Concept: mannosylglycerate hydrolase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the reaction: H2O + 2-(alpha-D-mannosyl)-D-glycerate <=> alpha-D-mannose + D-glycerate." + }, + { + "input": "Concept: Bronchial Epithelial Dysplasia (Dysplasia)", + "output": "something described as a non-invasive, precancerous lesion in the bronchial epithelium. Depending on the morphologic features it is classified as columnar cell dysplasia, basal cell dysplasia, squamous dysplasia, or bronchial epithelial dysplasia with transitional differentiation." + }, + { + "input": "Concept: Inclusion Exclusion Criterion Character Result in Standard Format (Quantitative Concept)", + "output": "Quantitative Concept described as the standard character or string for representation and reporting of inclusion exclusion criterion data." + }, + { + "input": "Concept: LAMP, NON-HEATING, FOR ADJUNCTIVE USE IN PAIN THERAPY (Medical Device)", + "output": "Medical Device described as an infrared lamp is a device intended for medical purposes that emits energy at infrared frequencies (approximately 700 nanometers to 50,000 nanometers) to provide topical heating." + }, + { + "input": "Concept: positive regulation of cell activation (regulation of cell activation)", + "output": "something described as any process that activates or increases the frequency, rate or extent of activation." + }, + { + "input": "Concept: DCEG (Component of the National Cancer Institute)", + "output": "something described as the Division of Cancer Epidemiology and Genetics (DCEG) is the primary focus within the National Cancer Institute for population based research on environmental and genetics determinants of cancer. Intramural and collaborative interdisciplinary studies are conducted on the distribution, causes, and natural history of cancer, and the means for its prevention. Research areas of special interest include genetic predisposition, lifestyle factors, environmental contaminants, occupational exposures, medications, radiation and infectious agents, as well as statistics and methods development." + }, + { + "input": "Concept: Health Problems Effect on Work Score 6 (Clinical or Research Assessment Answer)", + "output": "Intellectual Product described as a subjective score of 6 on a scale that ranges from 0: Health problems had no effect on my work to 10: Health problems completely prevented me from working." + }, + { + "input": "Concept: tracheal pit formation in open tracheal system (Organ or Tissue Function)", + "output": "Organ or Tissue Function described as formation of the tracheal pits, the first tube-like structures to form in the open tracheal system. Once cells are determined to their tracheal cell fate, the tracheal pits arise by invagination of each ectodermal cluster of tracheal placode cells, between 5 and 7 hours after egg laying. An example of this is found in Drosophila melanogaster." + }, + { + "input": "Concept: Anti-TnMUC1-CAR-expressing Autologous T-lymphocytes (therapeutic autologous lymphocytes)", + "output": "therapeutic autologous lymphocytes described as a preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) Tn glycoform of mucin-1 (Tn-MUC1; TnMUC1), with potential antineoplastic and immunostimulating activities. Upon re-introduction into the patient, the autologous Tn-MUC1-specific CAR T-lymphocytes specifically recognize and induce selective toxicity in TnMUC1-expressing tumor cells. TnMUC1 is overexpressed in certain tumor types." + }, + { + "input": "Concept: RNA formation (Genetic Function)", + "output": "something described as the chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." + }, + { + "input": "Concept: PUMP, NEBULIZER, MANUAL (Medical Device)", + "output": "Medical Device described as an ear, nose, and throat drug administration device is one of a group of ear, nose, and throat devices intended specifically to administer medicinal substances to treat ear, nose, and throat disorders. These instruments include the powder blower, dropper, ear wick, manual nebulizer pump, and nasal inhaler." + }, + { + "input": "Concept: HLA-A Mismatch Count (HLA Mismatch Count)", + "output": "Laboratory Procedure described as the determination of the number of mismatch between the study subject and his or her donor for the human leukocyte antigen, class I, group A (HLA-A)." + }, + { + "input": "Concept: ICL - idiopathic CD4 lymphocytopenia (Immunodeficiency disorders NEC)", + "output": "Immunodeficiency associated with chromosomal abnormality described as a rare primary immunodeficiency disorder with characteristics of persistent CD4 T-cell lymphopenia (less than 300 cells/UL on multiple occasions) not associated with any other underlying primary or secondary immune deficiency. Patients typically present opportunistic infections (with cryptococcal, mycobacterial, candidal, varicella zoster virus infections and progressive multifocal leukoencephalopathy being the most prevalent), malignancies (mainly lymphoproliferative disorders), or autoimmune disorders. Some individuals are asymptomatic and incidentally diagnosed." + }, + { + "input": "Concept: PERIOSTEITIS (Bone Diseases)", + "output": "Bone disorders NEC described as inflammation of the periosteum []" + }, + { + "input": "Concept: Cyclic ketone (Organic Chemical)", + "output": "Ketones described as any ketone containing a ring structure." + }, + { + "input": "Concept: Grade 3 Hypotension (Hypotension, CTCAE)", + "output": "Finding described as medical intervention indicated; hospitalization indicated" + }, + { + "input": "Concept: Rod Outer Segment (Zone of rod cell)", + "output": "Zone of rod cell described as the portion of a retinal rod cell situated between the ROD INNER SEGMENT and the RETINAL PIGMENT EPITHELIUM. It contains a stack of photosensitive disk membranes laden with RHODOPSIN." + }, + { + "input": "Concept: caregivers (Persons)", + "output": "Social/Family Issues described as any individual who provides care to those who need supervision or assistance in illness or disability; they may provide the care in the home, in a hospital, or in an institution; although caregivers include trained medical, nursing, and other health personnel, the concept usually refers to parents, spouses, or other family members, friends, etc.; this term includes the concept of caregiver burden." + }, + { + "input": "Concept: Loss of gluteal subcutaneous adipose tissue (Finding)", + "output": "Adipose tissue loss described as loss (reduction of previously present) of subcutaneous adipose tissue in the gluteal region." + }, + { + "input": "Concept: GPI0100 (Vaccine Adjuvant)", + "output": "Vaccine Adjuvant described as a semi-synthetic triterpene glycoside, derived from the naturally occurring saponins. GPI-0100 functions as an adjuvant when given as part of a vaccine preparation to improve the immunogenicity of antigens such as proteins, carbohydrates. GPI-0100 containing vaccines have been used with both viral and tumor antigens to elicit a Type 1 helper T cell response for those diseases in which a cytotoxic T lymphocyte (CTL) response is desired." + }, + { + "input": "Concept: HADS0112 (Intellectual Product)", + "output": "HADS Questionnaire Question described as hospital Anxiety and Depression Scale (HADS) I look forward with enjoyment to things." + }, + { + "input": "Concept: interim clinical trial/study report (Intellectual Product)", + "output": "system output described as a report of intermediate results and their evaluation based on planned analyses performed during the course of a trial." + }, + { + "input": "Concept: xanthosine metabolic process (purine ribonucleoside metabolic process)", + "output": "Molecular Function described as the chemical reactions and pathways involving xanthosine." + }, + { + "input": "Concept: Denture Base Resins, Self-Cured (Biomedical or Dental Material)", + "output": "Biomedical or Dental Material described as denture base resins that polymerize after the addition of the catalyst without the addition of heat (i.e., self-cured, also called cold-cured). These resins usually consist of an acrylic monometer of methyl methacrylate (typically supplied as a powder) that becomes a polymer (polymethyl methacrylate or PMMA) when mixed with a catalyst such as benzoyl peroxide (typically supplied as a liquid); reinforcing fillers may be included in the resin to increase its strength and/or durability. Self-cured resins used for denture bases should be biocompatible and resistant to oral cavity fluids, provide good mechanical and esthetic properties, and should be also easy to repair. They are used in dental laboratories." + }, + { + "input": "Concept: host cell synaptic vesicle membrane (host cell cytoplasmic vesicle membrane)", + "output": "host cell cytoplasmic vesicle membrane described as the lipid bilayer surrounding a host synaptic vesicle." + }, + { + "input": "Concept: Toe Amputation Saws (Saws, Surgical, Amputation)", + "output": "Medical Device described as surgical saws designed to completely or partially amputate a finger or toe. These saws are typically handheld, manual instruments (resembling a knife) with a metal structure including a handle and a detachable or integral serrated blade. Finger/toe amputation manual saws are intended to totally or partially cut fingers (metacarpal) and/or toes during surgical procedures." + }, + { + "input": "Concept: TAF12 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 20kDa wt Allele (Gene or Genome)", + "output": "Gene or Genome described as human TAF12 wild-type allele is located in the vicinity of 1p35.3 and is approximately 40 kb in length. This allele, which encodes transcription initiation factor TFIID subunit 12 protein, is involved in the regulation of RNA polymerase II-mediated transcription." + }, + { + "input": "Concept: Histone Cluster 1, H2ad Gene (H2AC7 Gene)", + "output": "something described as human H2AC7 wild-type allele is located in the vicinity of 6p22.2 and is approximately 1 kb in length. This allele, which encodes histone H2A type 1-D protein, plays a role in chromatin formation." + }, + { + "input": "Concept: Temperature Capability Range (Quantitative Concept)", + "output": "something described as an integer falling within minimum and maximum bounds that specifies the temperature capability of the system." + }, + { + "input": "Concept: Pubertal functions (Physiologic Function)", + "output": "Physiologic Function described as functions associated with the onset of puberty and manifestations of primary and secondary sexual characteristics." + }, + { + "input": "Concept: Resectable Renal Cell Carcinoma (Resectable Carcinoma)", + "output": "something described as renal cell carcinoma that is amenable to surgical resection." + }, + { + "input": "Concept: Locally Advanced Liposarcoma (Liposarcoma metastatic)", + "output": "Neoplastic Process described as a liposarcoma that has spread from its original site of growth to nearby tissues or lymph nodes." + }, + { + "input": "Concept: Refrigeration (Biologic Preservation)", + "output": "Machine Activity described as the mechanical process of cooling." + }, + { + "input": "Concept: KIT, DISC, AGAR GEL DIFFUSION, DETERMINE SERUM LEVELS OF KANAMYCIN (Medical Device)", + "output": "Medical Device described as a kanamycin test system is a device intended to measure kanamycin, an antibiotic drug, in plasma and serum. Measurements obtained by this device are used in the diagnosis and treatment of kanamycin overdose and in monitoring levels of kanamycin to ensure appropriate therapy." + }, + { + "input": "Concept: Hepatitis E Virus Antigen Measurement (Laboratory Procedure)", + "output": "Laboratory Procedure described as a measurement of the Hepatitis E virus antigen in a biological specimen." + }, + { + "input": "Concept: Abstracting as Topic (alteration integrity)", + "output": "Informatics described as the process of creating a summary of the main points of an article, argument, or theory." + }, + { + "input": "Concept: Richieri Costa Pereira syndrome (Hereditary disorder of musculoskeletal system)", + "output": "Hereditary disorder of musculoskeletal system described as syndrome with characteristics of short stature, Robin sequence, cleft mandible, pre/postaxial hand anomalies (including hypoplastic thumbs) and clubfoot. It has been described in 14 Brazilian families and in one unrelated French patient. Prominent low set ears and highly arched palate was also observed. Transmission is autosomal recessive. There is evidence this syndrome is caused by homozygous or compound heterozygous mutation in the EIF4A3 gene on chromosome 17q25." + }, + { + "input": "Concept: WPAI01TN (CDISC Questionnaire Terminology)", + "output": "CDISC Questionnaire Terminology described as test names of questionnaire questions associated with the the version 2.0 of the work productivity and activity impairment specific health problem questionnaire (WPAI:SHP) for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: SOURCE, BRACHYTHERAPY, RADIONUCLIDE (Medical Device)", + "output": "something described as a radionuclide brachytherapy source is a device that consists of a radionuclide which may be enclosed in a sealed container made of gold, titanium, stainless steel, or platinum and intended for medical purposes to be placed onto a body surface or into a body cavity or tissue as a source of nuclear radiation for therapy." + }, + { + "input": "Concept: HSP90-targeted SN-38 conjugate PEN-866 (Topoisomerase I Inhibitors)", + "output": "Topoisomerase I Inhibitors described as a miniature drug conjugate composed of the irinotecan metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) conjugated, through a cleavable linker, to a ligand of chaperone protein heat shock protein 90 (Hsp90), with potential antineoplastic activity. Upon administration of HSP90-targeted SN-38 conjugate PEN-866, the HSP90 ligand moiety targets HSP90, which allows the conjugate to penetrate, accumulate and be retained in the tumor cell. Once the linker is cleaved, the SN-38 moiety is released in a sustained manner. SN-38 then binds to and inhibits topoisomerase I by stabilizing the cleavable complex between topoisomerase I and DNA, which results in DNA breaks, inhibition of DNA replication and apoptosis. Compared to SN-38 alone, PEN-866 preferentially targets, accumulates and is retained in the tumor cells due to its binding to Hsp90, which results in increased concentrations of SN-38 at the tumor site. This allows sustained release of SN-38 and leads to increased and prolonged efficacy while reducing toxicity to normal, healthy tissues. Hsp90, a chaperone protein upregulated and activated in a variety of tumor cells compared to normal healthy tissue, regulates the folding, stability and degradation of many oncogenic signaling proteins." + }, + { + "input": "Concept: QIDSR1-Feeling Slowed Down (QIDS-SR Questionnaire Question)", + "output": "QIDS-SR Questionnaire Question described as quick Inventory of Depressive Symptomatology Self-Report Version (QIDS-SR) Please circle the one response to each item that best describes you for the past seven days: Feeling slowed down." + }, + { + "input": "Concept: (-)-isopiperitenone reductase activity (enone reductase activity)", + "output": "enone reductase activity described as catalysis of the reaction: (6R)-isoperitenone + H(+) + NADPH = (2R,5R)-isopulegone + NADP(+)." + }, + { + "input": "Concept: HHF6 (Disease or Syndrome)", + "output": "Digestive system hereditary disorder described as hyperinsulinism due to activating mutation(s) in the GLUD1 gene, encoding glutamate dehydrogenase 1. This condition is characterized by protein induced hypoglycemia and hyperammonemia, which is presumed to be due to increased ammonia production in the kidney." + }, + { + "input": "Concept: Proteolysis (Molecular Function)", + "output": "Biochemical Phenomena described as cleavage of proteins into smaller peptides or amino acids either by PROTEASES or non-enzymatically (e.g., Hydrolysis). It does not include Protein Processing, Post-Translational." + }, + { + "input": "Concept: Division Head (Research Personnel)", + "output": "Professional or Occupational Group described as the official that is responsible for the administrative, research and medical activities within a clinical program or subdivision of organization such as a hospital. A division head is responsible for the overall direction in the conduct of research; provision and coordination of training and education; operations, staffing, and maintenance of the facilities." + }, + { + "input": "Concept: encephalopathies (Physical & Psychosomatic Disorders)", + "output": "nervous system disorder described as degenerative diseases of the brain." + }, + { + "input": "Concept: Muscle fibre cytoplasmatic inclusion bodies (Muscle fiber inclusion bodies)", + "output": "something described as the presence of inclusion bodies within the cytoplasm of muscle cells. Inclusion bodies are aggregates (deposits) or stainable material, usually misfolded proteins." + }, + { + "input": "Concept: Capture Threshold, Unstable (Capturing Problem)", + "output": "Finding described as problem with the amount of output energy needed to cause cardiac depolarization being unstable." + }, + { + "input": "Concept: Ophthalmic Implants, Orbital Floor (Non-Active Implantable Devices)", + "output": "something described as ophthalmic implants designed to repair the floor of the bony cavity that contains the eyeball and its associated muscles, vessels, and nerves (i.e., the orbital floor). These implants may consist of flexible mesh made of either non-absorbable alloplastics (e.g., polyglactin, silastics), biologically absorbable materials (e.g., polyglicolic acid), or metallic (e.g., titanium); some consist of pre-punched solid alloplastics (e.g., expanded polytetrafluoroethylene also known as e-PTFE) available in several shapes (e.g., triangular, round, square) and sizes. Orbital floor implants are mainly used to treat orbital fractures (e.g., blow-out fractures); they are also used to correct other traumatic or non-traumatic volume deficiency in the orbital floor. These implants are frequently used for reconstruction of orbital wall defects." + }, + { + "input": "Concept: TRKB Gene Alteration Positive (Laboratory or Test Result)", + "output": "something described as a finding indicating that mutation, overexpression or rearrangement of the NTRK2 gene has been detected in a sample." + }, + { + "input": "Concept: oligonucleotidase activity (Genetic Function)", + "output": "something described as catalysis of the exonucleolytic cleavage of oligonucleotides to yield nucleoside 5'-phosphates." + }, + { + "input": "Concept: Autosomal recessive congenital methaemoglobinaemia type I (NADH cytochrome B5 reductase deficiency)", + "output": "something described as in type 1 cyanosis from birth is the only symptom, it is well tolerated and is associated with mild complaints of headaches, fatigue and shortness of breath upon exertion. Caused by mutations of the CYB5R3 gene (22q13.31-qter) encoding the NADH-cytochrome b5 reductase (Cb5R) and Cb5R deficiency is limited to the erythrocytes." + }, + { + "input": "Concept: Ophthalmic contact lens radius measuring device (Medical Device)", + "output": "Ophthalmological equipment described as an ophthalmic contact lens radius measuring device is an AC-powered device that is a microscope and dial gauge intended to measure the radius of a contact lens." + }, + { + "input": "Concept: Associated Persons Death Details (Intellectual Product)", + "output": "something described as a domain utilized for the submission of death details records related to persons associated with the study subject." + }, + { + "input": "Concept: Silver-gray hair color (Generalized hypopigmentation of hair)", + "output": "Generalized hypopigmentation of hair described as hypopigmented hair that appears silver-gray." + }, + { + "input": "Concept: MHC Class I Antigen G (Histocompatibility Antigens Class I)", + "output": "Histocompatibility Antigens Class I described as HLA class I histocompatibility antigen, alpha chain G (338 aa, ~38 kDa) is encoded by the human HLA-G gene. This protein is involved in the mediation of antigen presentation and processing." + }, + { + "input": "Concept: Cells, NIH 3T3 (3T3 Cells)", + "output": "something described as an immortalized fibroblast cell line derived from a mouse embryo in 1962 by George Todaro and Howard Green. These cells retain contact inhibition." + }, + { + "input": "Concept: IMMUNOPHENOTYPIC CR (Disease Response)", + "output": "Finding described as the disappearance of all signs of cancer, supported by the absence of phenotypically aberrant plasma cells (clonal) in bone marrow. (Rajkumar SV, Harousseau J, Durie B et al, Consensus recommendations for the uniform reporting of clinical trials: report of the International Myeloma Workshop Consensus Panel 1. Blood. 2011; 117(18):4691-4695)" + }, + { + "input": "Concept: anti-erbB2 monoclonal antibody (Pharmacologic Substance)", + "output": "Antibodies, Neoplasm described as a monoclonal antibody that binds to HER2 (human epidermal growth factor receptor 2), and can kill HER2-positive cancer cells. Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells. Trastuzumab is used to treat breast cancer that is HER2-positive and has spread after treatment with other drugs. It is also used with other anticancer drugs to treat HER2-positive breast cancer after surgery. Trastuzumab is also being studied in the treatment of other types of cancer." + }, + { + "input": "Concept: Central Nervous System Vascular Malformation (Vascular anomaly)", + "output": "Non-Neoplastic Central Nervous System Disorder described as congenital, inherited, or acquired abnormalities involving ARTERIES; VEINS; or venous sinuses in the BRAIN; SPINAL CORD; and MENINGES." + }, + { + "input": "Concept: I-PDT (Therapeutic or Preventive Procedure)", + "output": "Photochemotherapy described as photodynamic therapy that uses light-emitting fibers to treat deep-seated solid tumors." + }, + { + "input": "Concept: Nasopharyngeal Cancer pN3 TNM Finding v6 (Nasopharyngeal Cancer Pathologic Regional Lymph Nodes TNM Finding v6)", + "output": "something described as nasopharyngeal cancer with metastasis to one or more lymph nodes greater than 6 cm and/or to lymph nodes which are whole or in part in the supraclavicular fossa." + }, + { + "input": "Concept: Thymelaeaceae Juss., 1789 (Plant)", + "output": "something described as a plant family of the order Myrtales, subclass Rosidae, class Magnoliopsida. They are mainly trees and shrubs. Many members contain mucilage and COUMARINS." + }, + { + "input": "Concept: Acute Myeloid Leukemia with t(17;17)(q21;q21) (Acute Myeloid Leukemia with a Variant RARA Translocation)", + "output": "Neoplastic Process described as acute myeloid leukemia with the variant RARA t(17;17)(q21;q21) and the expression of STAT5B-RARA fusion protein." + }, + { + "input": "Concept: Study Agent Status Code (Code)", + "output": "Code described as a coded value specifying the phase in the lifecycle of the agent's association to a study. EXAMPLE(S): pending, active, complete, cancelled" + }, + { + "input": "Concept: Parasitoses, Ekbom Delusional (Schizophrenia Spectrum and Other Psychotic Disorders)", + "output": "something described as a delusional disorder of belief in infestation by insects or other parasites. This FORMICATION is typically accompanied by dermatological manifestation such as PRURITUS that may lead to self-mutilation in order to remove the perceived parasites. It can be either primary or secondary to a somatic or psychiatric condition." + }, + { + "input": "Concept: PerformedObservation.targetAnatomicSiteCode (Intellectual Product)", + "output": "something described as a coded value specifying the anatomic location that is the focus of the observation. EXAMPLE(S): Lower intestine for a colonoscopy observation OTHER NAME(S): NOTE(S): The target site of the result may be different than the target site of the activity (PerformedObservation) that generated it. For example, a chest x-ray (observation) has the target site of chest while the result might show an infiltration in the left lower lobe of the lung (target site of result), or a dermatological exam may check the skin across the whole body (target site of observation) while the result might identify a rash on the right leg (target site of result). Neither target anatomic site nor approach anatomic site is necessarily required or relevant for certain observations, however if either or both are present then the distinction between them is that the approach site is where the measurement or observation is performed and the target site is what is ultimately being evaluated. The target site is often implicit in the definition of the observation itself. Sources that capture anatomic site and laterality separately should map both to this attribute. For implementation models based on BRIDG where site and laterality are captured separately, you may wish to capture both concepts as a post-coordinated code structure or as multiple code repetitions" + }, + { + "input": "Concept: rhamnogalacturonan I biosynthesis (rhamnogalacturonan I metabolic process)", + "output": "polysaccharide biosynthetic process described as the chemical reactions and pathways resulting in the formation of rhamnogalacturonan I component of pectin, a rhamnose-rich pectic polysaccharide." + }, + { + "input": "Concept: Neuroendocrine Carcinoma of Unknown Primary (Neoplastic Process)", + "output": "something described as a neuroendocrine carcinoma that has metastasized from an unknown primary site." + }, + { + "input": "Concept: choroid plexus; calcification (Pathologic Function)", + "output": "Pathologic Function described as the presence of calcium deposition in the choroid plexus." + }, + { + "input": "Concept: BTG2 (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as protein BTG2 (158 aa, ~17 kDa) is encoded by the human BTG2 gene. This protein plays a role in the regulation of both cell proliferation and transcription." + }, + { + "input": "Concept: Non-Opioid Analgesic (Clinical or Research Assessment Answer)", + "output": "Finding described as a response that indicates the patient used a non-opioid analgesic." + }, + { + "input": "Concept: social competition (Social Behavior)", + "output": "something described as rivalry between two or more individuals striving for the same goals; may also be used in relation to economics as an effort of two or more parties to secure the business of a third party by offering, usually under fair or equitable rules of business practice." + }, + { + "input": "Concept: vanadium-iron nitrogenase complex (nitrogenase complex)", + "output": "something described as an enzyme complex containing a vanadium-iron cluster found in some species, such as Azotobacter vinelandii. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the vanadium-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer." + }, + { + "input": "Concept: adenoviral-transduced hIL-12-expressing autologous dendritic cells INXN-3001 plus activator ligand INXN-1001 (Genetically-engineered Immune Cell)", + "output": "Antineoplastic Immune Cell described as autologous dendritic cells tranduced with a replication incompetent adenovirus encoding human pro-inflammatory cytokine interleukin-12 (IL-12) (INXN-3001) in combination with the proprietary orally bioavailable, small molecule activator ligand INXN-1001, with potential immunomodulating and antineoplastic activities. Production of IL-12 is controlled by an inducible DNA element that allows transcription initiation only in the presence of the ligand inducer INXN-1001. Upon intratumoral injection of INXN-3001 and subsequent oral administration of activator ligand, INXN-1001 is able to induce expression of IL-12 in INXN-3001. IL-12 expressed by the adenovirus may activate the immune system by promoting the activation of natural killer cells, inducing the secretion of interferon-gamma and inducing a cytotoxic T lymphocyte response against tumor cells, which may result in immune-mediated tumor cell death and inhibition of tumor cell proliferation. As INXN-1001 regulates both the timing and the levels of IL-12 expression, IL-12 toxicity can be reduced." + }, + { + "input": "Concept: CEA PEP 1-6D (Carcinoembryonic Antigen Peptide)", + "output": "Amino Acid, Peptide, or Protein described as a 9-residue human leukocyte antigen (HLA)-restricted fragment of carcinoembryonic antigen (CEA). CEA:571-579 peptide, which has the amino acid sequence YLSGANLNL, may elicit a cytotoxic T lymphocyte (CTL) immune response against tumors expressing CEA. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2622\" active clinical trials using this agent." + }, + { + "input": "Concept: Grade 3 Budd-Chiari syndrome (Budd-Chiari Syndrome, CTCAE)", + "output": "Budd-Chiari Syndrome, CTCAE described as severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; asterixis; mild encephalopathy" + }, + { + "input": "Concept: Overgrowth Syndrome (Syndrome)", + "output": "something described as a group of syndromes caused by genetic birth defects that may lead to the development of malignancies. It is characterized by a large body size or large body parts at birth, or excessive body growth early in childhood. Representative examples include neurofibromatosis, Beckwith-Wiedemann syndrome, and Sturge-Weber syndrome." + }, + { + "input": "Concept: Microwave Radiations (Occupational Activity)", + "output": "Sterilization for infection control described as a sterilization process that uses nonionizing radiation at frequencies between 300MHz and 300GHz in the microwave region to kill microorganisms." + }, + { + "input": "Concept: alphaV-beta3 integrin-gelsolin complex (plasma membrane protein complex)", + "output": "something described as a protein complex that consists of an alphaV-beta3 integrin complex bound to gelsolin." + }, + { + "input": "Concept: Proline measurement (Amino acids measurement)", + "output": "something described as the determination of the amount of proline present in a sample." + }, + { + "input": "Concept: TOR activity (oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor)", + "output": "Molecular Function described as catalysis of the reaction: trimethylamine + 2 (ferricytochrome c)-subunit + H2O = trimethylamine-N-oxide + 2 (ferrocytochrome c)-subunit + 2 H+." + }, + { + "input": "Concept: BEBQ01-Baby Is Always Demanding a Feed (BEBQ Concurrent Version Questionnaire Question)", + "output": "something described as baby Eating Behaviour Questionnaire - Concurrent - My baby is always demanding a feed." + }, + { + "input": "Concept: regulation of synaptic transmission, dopaminergic (modulation of chemical synaptic transmission)", + "output": "modulation of chemical synaptic transmission described as any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." + }, + { + "input": "Concept: SDTM-FATESTCD (Unused Subset Concept)", + "output": "something described as terminology associated with the findings about test code codelist of the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: 5: 139706358-139692613 (Spatial Concept)", + "output": "Spatial Concept described as physical location of DTR_Gene" + }, + { + "input": "Concept: Borg Category-Ratio 10 Scale Questionnaire (Intellectual Product)", + "output": "Intellectual Product described as borg CR10 Scale (BORG CR10) (Borg CR10 Scale. Copyright Gunnar Borg, 1981, 1982, 1998)." + }, + { + "input": "Concept: drug screen propoxyphene (drug screen class)", + "output": "Definitive Drug Testing Procedures described as a measurement of the propoxyphene present in a biological specimen." + }, + { + "input": "Concept: Inadequate caloric intake (Dietary history)", + "output": "something described as the daily caloric intake is deficient." + }, + { + "input": "Concept: Other Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders (Disease or Syndrome)", + "output": "Disease or Syndrome described as lymphoid proliferations or lymphomas that arise in patients treated with immunosuppressive drugs for autoimmune diseases or conditions other than in the post-transplant setting." + }, + { + "input": "Concept: GRAM POSITIVE IDENTIFICATION PANEL (Medical Device)", + "output": "something described as a microorganism differentiation and identification device is a device intended for medical purposes that consists of one or more components, such as differential culture media, biochemical reagents, and paper discs or paper strips impregnated with test reagents, that are usually contained in individual compartments and used to differentiate and identify selected microorganisms. The device aids in the diagnosis of disease." + }, + { + "input": "Concept: BIURET (COLORIMETRIC), TOTAL PROTEIN (Medical Device)", + "output": "Medical Device described as a total protein test system is a device intended to measure total protein(s) in serum or plasma. Measurements obtained by this device are used in the diagnosis and treatment of a variety of diseases involving the liver, kidney, or bone marrow as well as other metabolic or nutritional disorders." + }, + { + "input": "Concept: Risk for disturbed personal identity (Finding)", + "output": "Self Concept described as susceptible to the inability to maintain an integrated and complete perception of self, which may compromise health." + }, + { + "input": "Concept: mRNA-based TriMixMelanoma vaccine ECI-006 (Pharmacologic Substance)", + "output": "Immunologic Factor described as a melanoma vaccine consisting of mRNAs encoding five different melanoma tumor-associated antigens (TAAs) and a TriMix platform comprised of three mRNAs encoding for constitutively activated toll-like receptor 4 (caTLR4), CD40 ligand (CD40L), and CD70, with potential immunomodulatory and antineoplastic activities. Upon intranodal injection, mRNA based TriMix vaccine ECI-006 may stimulate the immune system to mount both humoral and cellular responses against tumor cells expressing the five TAAs specific to the vaccine, potentially decreasing cellular proliferation of cells expressing these antigens. The TriMix adjuvants CD40L and caTLR4 promote the generation of mature and active dendritic cells (DCs), and CD70 provides a costimulatory signal to CD27+ naive T-cells, thereby supporting T-cell proliferation and inhibiting T-cell apoptosis." + }, + { + "input": "Concept: Loss of Power (Finding)", + "output": "Finding described as problem associated with the failure of primary power supplied by the facility." + }, + { + "input": "Concept: Denmark (Scandinavia)", + "output": "Geographic Area described as a country in northern Europe, bordering the Baltic Sea and the North Sea. The capital is Copenhagen." + }, + { + "input": "Concept: sabinene synthase activity (terpene synthase activity)", + "output": "terpene synthase activity described as catalysis of the reaction: geranyl diphosphate = sabinene + diphosphate." + }, + { + "input": "Concept: Swish and Spit Route of Administration (Functional Concept)", + "output": "something described as administration of a liquid substance to the oral mucosa by swishing the drug inside the mouth for a certain amount of time then spiting it out. The drug action is mostly topical/local." + }, + { + "input": "Concept: Chronic brain-hydrocephalus syndrome (Brain Damage, Chronic)", + "output": "something described as a language disorder in mentally retarded but educable children who have the ability to learn words and to talk, without knowing what they are talking about. They love to chatter, but think illogically." + }, + { + "input": "Concept: Catheters, Transtracheal Oxygen (Miscellaneous Supplies)", + "output": "something described as transtracheal catheters designed for efficient direct delivery of oxygen into the lungs, improving comfort, therapeutic compliance (e.g., relief of apnea), and activity status when compared with nasal cannulas. These catheters consist of either a percutaneously introduced tube that has a long intratracheal portion with multiple fenestrations or a tunneled silicone tube that is surgically inserted under local or general anesthesia and usually includes a shorter intratracheal portion. The oxygen supply is obtained from a stationary compressed-gas cylinder, a cryogenic liquid reservoir, or an ambient air concentrator; portable systems are available for ambulatory patients. Oxygen-supply transtracheal catheters are used for long-term oxygen therapy in patients with chronic oxygen-dependent respiratory failure (e.g., chronic obstructive pulmonary disease, interstitial fibrosis, diffusion defect)." + }, + { + "input": "Concept: FACIT-Dyspnea Scale 33 Item Bank Version - Severity: Standing 5 Minutes Why Not (Intellectual Product)", + "output": "something described as functional Assessment of Chronic Illness Therapy-Dyspnea Scale 33 Item Bank (FACIT-Dyspnea Scale 33 Item Bank Version) Dyspnea Severity: Over the past 7 days, how short of breath did you get with each of these activities?: Standing for at least 5 minutes. Please indicate why you did not do this in the past 7 days." + }, + { + "input": "Concept: SCF complex (cullin-RING ubiquitin ligase complex)", + "output": "something described as a ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." + }, + { + "input": "Concept: PSA Level Less than 0.7 (PSA Level Finding)", + "output": "something described as a blood concentration of prostate specific antigen less than 0.7 ng/mL." + }, + { + "input": "Concept: Direct Mixed Photon and Electron Field (Body Location or Region)", + "output": "something described as a radiation therapy technique where external photon and electron beams are used to deliver treatment of superficial and deep-seated malignancies, respectively, while sparing underlying organs at risk." + }, + { + "input": "Concept: Adenoca in situ in a polyp (Neoplastic Process)", + "output": "Adenocarcinoma in situ in adenomatous polyp described as an adenocarcinoma arising in a polyp." + }, + { + "input": "Concept: Metapneumoviruses (Pneumovirinae)", + "output": "Pneumovirinae described as any viral organism that can be assigned to the genus Metapneumovirus." + }, + { + "input": "Concept: SOM (Intellectual Product)", + "output": "something described as terminology subset about physical conditions describing the molecular form of a product. Note: State of matter is used to group basic dose forms according to their physical properties." + }, + { + "input": "Concept: cos cell (Cell)", + "output": "Fibroblasts described as CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning. (The CV-1 cell line was derived from the kidney of an adult male African green monkey (CHLOROCEBUS AETHIOPS).)" + }, + { + "input": "Concept: HOUSEKEEPING HOSP (Hospital Departments)", + "output": "Health Care Activity described as hospital department which manages and provides the required housekeeping functions in all areas of the hospital." + }, + { + "input": "Concept: developmental induction (Developmental process)", + "output": "something described as a developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder)." + }, + { + "input": "Concept: Enterobacter amnigenus (Enterobacter)", + "output": "Lelliottia described as any bacterial organism that can be assigned to the species Enterobacter amnigenus." + }, + { + "input": "Concept: Terminology Value Set (Information Resources)", + "output": "Information Resources described as a fixed group of data that can be selected for a given metadata attribute." + }, + { + "input": "Concept: response to iloperidone (response to organic cyclic compound)", + "output": "response to antipsychotic drug described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iloperidone stimulus." + }, + { + "input": "Concept: CDISC SDTM Multiple Sclerosis Findings About Test Code Terminology (CDISC SDTM Terminology)", + "output": "Intellectual Product described as terminology associated with the multiple sclerosis findings about test codes codelist of the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: VAPORIZERS NEBULIZERS (Medical Device)", + "output": "Surgical Equipment described as devices that cause a liquid or solid to be converted into an aerosol (spray) or a vapor. It is used in drug administration by inhalation, humidification of ambient air, and in certain analytical instruments." + }, + { + "input": "Concept: 2nd degree burn NOS (Injury or Poisoning)", + "output": "something described as an injury that includes the entire epidermis and upper layers of the dermis due to a chemical, friction, radiation or thermal exposure. The affected area appears as moist red or white skin that does not blanch. Often it is painful with the presence of blisters." + }, + { + "input": "Concept: regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism (regulation of cellular metabolic process)", + "output": "regulation of nitrogen compound metabolic process described as any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." + }, + { + "input": "Concept: 23c (Body Location or Region)", + "output": "Body Location or Region described as a portion of the posterior cingulate gyrus defined on the basis of cytoarchitecture and connectivity in the macaque ( Vogt-1987 ). It is one of three subdivisions of area 23 (macaque). The other two are area 23a (macaque) and area 23b (macaque). Area 23c is located furthest from the corpus callosum in the ventral wall of the cingulate sulcus . An equivalent area exists in the human ( Vogt-1995 ). For a more recent segmentation of this area by the same authors later in their studies ( Vogt-2012 ) see area 23." + }, + { + "input": "Concept: Abscess, Subdiaphragmatic (Abdominal and gastrointestinal infections)", + "output": "Abdominal wall conditions NEC described as an abscess that is located in the anatomical space between the diaphragm and the liver and/or spleen." + }, + { + "input": "Concept: Knowledge acquisition (SOCIAL CONTEXT: GENERAL CONDITIONS)", + "output": "Anthropology, Education, Sociology and Social Phenomena described as acquisition of knowledge as a result of instruction in a formal course of study; also the field of study that deals mainly with methods of teaching and learning in schools." + }, + { + "input": "Concept: Stage 3 (International Neuroblastoma Staging System)", + "output": "something described as the tumor extends across the midline and the regional lymph nodes may or may not be involved by tumor; or the tumor is unilateral and the contralateral lymph nodes are involved by tumor; or the tumor is in midline and there is bilateral lymph node involvement by tumor." + }, + { + "input": "Concept: Laryngotracheal cleft (Congenital Abnormality)", + "output": "Abnormal larynx morphology described as presence of a gap in the posterior laryngotracheal wall with a continuity between the larynx and the esopahagus." + }, + { + "input": "Concept: GASTROINTESTINAL ARTERIOVENOUS MALFORMATION (Vascular malformations and acquired anomalies)", + "output": "Vascular malformations and acquired anomalies described as an anomalous configuration of blood vessels that shunts arterial blood directly into veins without passing through the capillaries and that is located in the gastrointestinal tract. []" + }, + { + "input": "Concept: Grade 1 Anemia (Anemia, CTCAE)", + "output": "something described as hemoglobin (Hgb) PerformedObservation > PerformedObservationResult.value (ANY=>PQ.TIME) WHERE PerformedObservation > DefinedObservation.nameCode = \"weight\"" + }, + { + "input": "Concept: neurotoxin (Poisons)", + "output": "Hazardous or Poisonous Substance described as a substance that is poisonous to nerve tissue." + }, + { + "input": "Concept: MIC50FCR (Laboratory test finding)", + "output": "Finding described as a fold change based on the concentration of a specific drug expected to produce 50 percent inhibition on the enzymatic activity of a microbial organism; it is a ratio calculated by the IC50 Subject Result divided by the IC50 Reference Control Result." + }, + { + "input": "Concept: BEBQ Retrospective Version - Baby Would Always Be Feeding (BEBQ Retrospective Version Questionnaire Question)", + "output": "BEBQ Retrospective Version Questionnaire Question described as baby Eating Behaviour Questionnaire - Retrospective - If given the chance, my baby would always be feeding." + }, + { + "input": "Concept: negative regulation of NMJ stability (negative regulation of synapse organization)", + "output": "regulation of neuromuscular junction development described as any process that stops, prevents or reduces the frequency, rate or extent of neuromuscular junction development." + }, + { + "input": "Concept: Lip and Oral Cavity Carcinoma pT3 TNM Finding v8 (Lip and Oral Cavity Cancer Pathologic Primary Tumor TNM Finding v8)", + "output": "Lip and Oral Cavity Cancer Pathologic Primary Tumor TNM Finding v8 described as lip and oral cavity cancer with tumor size greater than 4 cm or any tumor greater than 10 mm DOI." + }, + { + "input": "Concept: cellular response to cholesterol (cellular response to sterol)", + "output": "Cell Function described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus." + }, + { + "input": "Concept: Feces: blood (Sign or Symptom)", + "output": "Gastrointestinal Diseases described as the presence of blood in fecal matter; usually as a result of gastrointestinal tract hemorrhage." + }, + { + "input": "Concept: toll-like receptor TLR1:TLR2 signaling pathway (Molecular Function)", + "output": "something described as a series of molecular signals initiated by the binding of a heterodimeric TLR1:TLR2 complex to one of it's physiological ligands, followed by transmission of the signal by the activated receptor, and ending with regulation of a downstream cellular process, e.g. transcription." + }, + { + "input": "Concept: Resolver (Medical Device)", + "output": "something described as a motor designed to interchange rectangular and polar coordinates or the TCP/IP software that sends requests to the Domain Name Server." + }, + { + "input": "Concept: Grade 1 Ureteric Anastomotic Leak, CTCAE (Ureteric Anastomotic Leak, CTCAE)", + "output": "something described as asymptomatic diagnostic finding; intervention not indicated" + }, + { + "input": "Concept: YWHAE-FAM22 Fusion Protein Expression (Fusion Protein Expression)", + "output": "Fusion Protein Expression described as expression of fusion protein YWHAE-FAM22 transcripts resulting from a t(10;17)(q22;p13). The translocation results in rearrangement of the YWHAE gene on chromosome 17 and FAM22 gene on chromosome 10. It has been described in high grade endometrial stromal sarcomas and a subset of clear cell sarcomas of the kidney." + }, + { + "input": "Concept: Oversight Committee (Professional Organization or Group)", + "output": "something described as an organization that approves, monitors and reviews biomedical research to protect the rights, safety and welfare of the study subjects. This committee performs critical oversight functions for research conducted on human study subjects that are scientific, ethical, and regulatory. EXAMPLE(S): Institutional Review Board (IRB), ethics committee, research ethics board OTHER NAME(S): NOTE(S):" + }, + { + "input": "Concept: xstng wlns45min (Existing client wellness visit with or without ICD diagnosis)", + "output": "something described as consulting in a detailed, 45-minute meeting with an existing client without medical or physical complaints." + }, + { + "input": "Concept: Salivary Gland Sialoblastoma (Salivary Gland Neoplasms)", + "output": "Salivary Gland Neoplasms described as a rare, congenital or perinatal, aggressive and potentially low-grade malignant, basaloid neoplasm that occurs in the major salivary glands. It typically presents as a mass over the angle of the mandible. Most involve the parotid gland." + }, + { + "input": "Concept: plannedSiteNumberRange (Range)", + "output": "something described as an integer falling within minimum and maximum bounds that specifies the number of study sites that are expected to participate in the study." + }, + { + "input": "Concept: grinding teeth disorders (Repetitive routines)", + "output": "Mannerism described as oral habit involving involuntary rhythmic or spasmodic nonfunctional gnashing, grinding and clenching of teeth, usually during sleep." + }, + { + "input": "Concept: ADNI AVLT - List A Recognition Intrusions (Intellectual Product)", + "output": "Intellectual Product described as auditory Verbal Learning Test Version A - The number of intrusions on recognition test." + }, + { + "input": "Concept: Pressurised conventional release suspension for inhalation (Pressurised inhalation)", + "output": "Biomedical or Dental Material described as liquid, usually multidose preparation consisting of a suspension intended for inhalation use. The preparation is presented in a pressurized container fitted with a metering dose valve." + }, + { + "input": "Concept: Catheters, Cardiac, Microflow (Medical Device)", + "output": "Cardiac Catheters described as cardiac catheters designed for catheterization of small-lumen (typically of less than 1 mm) cardiac vasculature. These catheters typically consist of 1.5 or 1.8 French tubes that are directed using the cardiac venous system into the cardiac vasculature. Some of these catheters include hydrophilic coating for easy movement, as well as mini electrodes near their distal tip. These catheters are used for electrophysiologic studies and in the diagnosis and/or treatment of ventricular tachycardia." + }, + { + "input": "Concept: Right Ventricular Dysfunction (Myocardial disorders NEC)", + "output": "Ventricular Dysfunction described as impairment of the right ventricular function associated with low ejection fraction and decreased motility of the right ventricular wall." + }, + { + "input": "Concept: Estimated intake of empty energy food servings in 24 hours (Quantitative Concept)", + "output": "Nutrient Intake described as the estimated amount of foods containing little or no nutritive value other than energy consumed per day." + }, + { + "input": "Concept: regulation of keratinocyte proliferation (regulation of epithelial cell proliferation)", + "output": "regulation of epithelial cell proliferation described as any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population." + }, + { + "input": "Concept: Cyclic Ether Carcinogen (Organic Carcinogen)", + "output": "Organic Carcinogen described as a cyclic compound in which two carbon atoms are linked through an oxygen atom and exposure to these compounds can increase the risk of cancer in humans." + }, + { + "input": "Concept: Circumscribed (Action)", + "output": "something described as to draw a geometric figure around another figure so that the two are in contact but do not intersect." + }, + { + "input": "Concept: papillary layer (Body Part, Organ, or Organ Component)", + "output": "Dermis described as the upper portion of the dermis beneath the epidermis. It is composed of thin collagen fibers." + }, + { + "input": "Concept: incisional hernia of abdomen (Abdominal hernias and other abdominal wall conditions)", + "output": "Complication of surgical procedure described as an abdominal hernia that occurs at a site of weakness in the abdominal wall resulting from an incompletely-healed surgical wound." + }, + { + "input": "Concept: METALLOPANSTIMULIN 1 (Ribosome Subunit Gene)", + "output": "Gene or Genome described as this gene is involved in DNA binding, RNA binding and protein synthesis. It also plays a role in regulation of cell proliferation." + }, + { + "input": "Concept: Rhodopsins, Sensory (Biologically Active Substance)", + "output": "Biologically Active Substance described as photosensory rhodopsins found in microorganisms such as HALOBACTERIA. They convert light signals into biochemical information that regulates certain cellular functions such as flagellar motor activity." + }, + { + "input": "Concept: Performed Notification (Notifications)", + "output": "something described as the completed activity within the context of a given study that represents the communication of a message to a recipient." + }, + { + "input": "Concept: Mechanical Clot Detection (Laboratory Procedure)", + "output": "Clot Detection described as a clot detection method that uses a mechanical means (electromagnetic mechanical or electromechanical) to detect the presence of or quantify the formation of a thrombus in a specimen." + }, + { + "input": "Concept: Chemokine (C-X-C Motif) Receptor 3 wt Allele (Gene or Genome)", + "output": "something described as human CXCR3 wild-type allele is located within Xq13 and is approximately 3 kb in length. This allele, which encodes C-X-C chemokine receptor type 3 protein, is involved in the recruitment of inflammatory cells and signal transduction." + }, + { + "input": "Concept: Hemagglutinin Glycoproteins, Influenza Virus (Immunologic Factor)", + "output": "something described as membrane glycoproteins from influenza viruses which are involved in hemagglutination, virus attachment, and envelope fusion. Fourteen distinct subtypes of HA glycoproteins and nine of NA glycoproteins have been identified from INFLUENZA A VIRUS; no subtypes have been identified for Influenza B or Influenza C viruses." + }, + { + "input": "Concept: microspherophakia (Microphakia)", + "output": "Microphakia described as lens of the eye is smaller than normal and spherically shaped. []" + }, + { + "input": "Concept: AQ01TN (CDISC Questionnaire Terminology)", + "output": "CDISC Questionnaire Terminology described as test names of questionnaire questions associated with the Airway Questionnaire 20 (AQ20) for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: mitochondrial FAD transmembrane transport (FAD transmembrane transport)", + "output": "Cell Function described as the process in which FAD is transported across a mitochondrial membrane, into or out of the mitochondrion." + }, + { + "input": "Concept: Male Female Relations (Intergroup Dynamics)", + "output": "Interpersonal Relations described as relationships or interactions between the sexes. Limited to human populations." + }, + { + "input": "Concept: GKD - Glycerol kinase defic (Disease or Syndrome)", + "output": "something described as deficiency of glycerol kinase (adenosine triphosphate:glycerol 3-phosphotransferase) associated with psychomotor retardation, osteoporosis, spasticity, esotropia, and bone fractures." + }, + { + "input": "Concept: Replication Initiation Factor (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as a protein that is involved in the initiation of the DNA replication process." + }, + { + "input": "Concept: Anisozygopteras (Epiprocta)", + "output": "Eukaryote described as a small suborder of Odonata that has members with intermediate morphology between Anisoptera and Zygoptera suborders." + }, + { + "input": "Concept: Acute Myocardial Ischemia ECG Change (ECG myocardial ischemia)", + "output": "Finding described as an electrocardiographic finding assessment of new or presumed new significant ST-segment-T wave (ST-T) changes or new left bundle branch block consistent with acute myocardial ischemia. (Thygesen K, Alpert JS, Jaffe AS, Simoons ML, et al.; Joint ESC/ACCF/AHA/WHF Task Force for Universal Definition of Myocardial Infarction. Third universal definition of myocardial infarction. J Am Coll Cardiol. 2012 Oct 16;60(16):1581-98)." + }, + { + "input": "Concept: Briard-Evans syndrome (Disease or Syndrome)", + "output": "something described as hydrocephalus occurring in conjunction with defects which are included in VACTERL association (vertebral anomalies, anal atresia, cardiac abnormalities, tracheoesophageal fistula, renal agenesis, and limb defects). Additional abnormalities may include microphthalmia, abnormal lung lobulation, and spleen defects. Two basic forms are recognized: The David-O'Callaghan syndrome and the Hunter-MacMurray syndrome which are almost identical, except for cardiovascular malformations which are present only in the first type and the mode of transmission. Prognosis for survival is generally poor; infants who survive are usually retarded." + }, + { + "input": "Concept: Nidovirales Infections (RNA Virus Infections)", + "output": "something described as infections with viruses of the order NIDOVIRALES. The concept includes ARTERIVIRUS INFECTIONS and CORONAVIRIDAE INFECTIONS." + }, + { + "input": "Concept: Simian mason-pfizer virus (Betaretrovirus)", + "output": "Virus described as a species of BETARETROVIRUS isolated from mammary carcinoma in rhesus monkeys. It appears to have evolved from a recombination between a murine B oncovirus and a primate C oncovirus related to the baboon endogenous virus. Several serologically distinct strains exist. MPMV induces SIMIAN AIDS." + }, + { + "input": "Concept: Investigators (Professional or Occupational Group)", + "output": "Personnel described as an individual who actually conducts a clinical investigation (i.e., under whose immediate direction the test article is administered or dispensed to, or used involving a subject, or, in the event of an investigation conducted by a team of individuals, is the responsible leader of that team). [21 CFR 50.3] See also sponsor-investigator, site investigator, principal investigator, coordinating investigator, sub-investigator." + }, + { + "input": "Concept: Sinonasal Adenocarcinoma, Intestinal-Type with Colonic Pattern (Neoplastic Process)", + "output": "Sinonasal Adenocarcinoma, Intestinal-Type described as an intestinal-type adenocarcinoma that arises from the sinonasal tract. It is characterized by the presence of a tubuloglandular growth pattern." + }, + { + "input": "Concept: Cyclin-Dependent Kinase Inhibitor AT7519M (Cyclin-Dependent Kinase Inhibitor Agents)", + "output": "Pharmacologic Substance described as a substance being studied in the treatment of some types of cancer. AT7519M blocks enzymes needed for cells to divide. It is a type of cyclin-dependent kinase inhibitor." + }, + { + "input": "Concept: Soil (Complex Mixtures)", + "output": "Geological Phenomena described as the unconsolidated mineral or organic matter on the surface of the earth that serves as a natural medium for the growth of land plants." + }, + { + "input": "Concept: Type B Cyclins (Cyclins)", + "output": "something described as a protein family whose members form complexes with cyclin-dependent kinase 1 to form maturation promoting factor (mitosis promoting factor; MPF), which is essential for the progression through the G2/M and DNA damage cell cycle checkpoints." + }, + { + "input": "Concept: Neoplasms, Head and Neck (Neoplasms by Site)", + "output": "Mass in head or neck described as a tumor (abnormal growth of tissue) of the head and neck region with origin in the lip, oral cavity, nasal cavity, paranasal sinuses, pharynx, or larynx." + }, + { + "input": "Concept: Grade 2 Musculoskeletal and connective tissue disorder - Other, specify (Musculoskeletal and Connective Tissue Disorder - Other, Specify, CTCAE)", + "output": "Finding described as moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL" + }, + { + "input": "Concept: C2-C3 subluxation (Cervical subluxation)", + "output": "something described as a partial dislocation of the intervertebral joint between the second and third cervical vertebrae." + }, + { + "input": "Concept: X: 9897925-9900718 (Spatial Concept)", + "output": "Chromosome X Physical Location described as physical location of CSF2RA_Gene" + }, + { + "input": "Concept: methanesulfonate,NADH:oxygen oxidoreductase activity (Molecular Function)", + "output": "something described as catalysis of the reaction: methanesulfonate + NADH + H+ + O2 = formaldehyde + NAD+ + sulfite + H2O." + }, + { + "input": "Concept: Use Stimulant Once a Week or More Often (Clinical or Research Assessment Question)", + "output": "something described as a question about whether an individual uses or used a stimulant at least once a week or more often." + }, + { + "input": "Concept: Phenylic acid (Sclerosing agents for local injection)", + "output": "Drug allergens described as a very poisonous chemical substance made from tar and also found in some plants and essential oils (scented liquid taken from plants). Phenol is used to make plastics, nylon, epoxy, medicines, and to kill germs." + }, + { + "input": "Concept: Ichthyosis-Cheek-Eyebrow Syndrome (Multiple malformation syndrome with facial defects as major feature)", + "output": "Disease or Syndrome described as this syndrome has features of ichthyosis, prominent full cheeks and sparse lateral eyebrows. It has been described in several individuals from four generations of one family. Transmission is autosomal dominant." + }, + { + "input": "Concept: cardiac myxomas (Benign neoplasm of endocardium)", + "output": "Benign neoplasm of endocardium described as a myxoma arising from the endocardium." + }, + { + "input": "Concept: Vulval cancer stage I (Vulvovaginal cysts and neoplasms)", + "output": "Neoplastic Process described as stage I includes: T1, N0, M0. T1: Tumor confined to the vulva or vulva and perineum, 2cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th ed.)." + }, + { + "input": "Concept: UPD122D (Intellectual Product)", + "output": "UPDRS Questionnaire Question described as unified Parkinson's Disease Rating Scale - Motor examination: Rigidity lower extremity: Right." + }, + { + "input": "Concept: Referring Pathologist (Professional or Occupational Group)", + "output": "Professional or Occupational Group described as a pathologist that directs a patient to an additional source of medical expertise for assistance, examination, information, or treatment." + }, + { + "input": "Concept: Trichoderma species (Hypocreaceae)", + "output": "Mitosporic Fungi described as a mitosporic fungal genus frequently found in soil and on wood. It is sometimes used for controlling pathogenic fungi. Its teleomorph is HYPOCREA." + }, + { + "input": "Concept: Biologics licensing application (Application to Market New Drug, Biologic, or Antibiotic for Human Use)", + "output": "something described as stability data submitted to a biologics license application." + }, + { + "input": "Concept: pectin biosynthetic process (pectin metabolic process)", + "output": "something described as the chemical reactions and pathways resulting in the formation of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues." + }, + { + "input": "Concept: D-glucono-1,5-lactone lactonohydrolase activity (Molecular Function)", + "output": "something described as catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate." + }, + { + "input": "Concept: Motor Behavior (Functions and Abnormal Functions of the Psyche)", + "output": "MOTOR BEHAVIOR AND DISTURBANCES described as any form of exercise or movement. Physical activity may include planned activity such as walking, running, basketball, or other sports. Physical activity may also include other daily activities such as household chores, yard work, walking the dog, etc." + }, + { + "input": "Concept: adult immunoblastic large cell lymphoma, stage IV (Neoplastic Process)", + "output": "Neoplastic Process described as ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid." + }, + { + "input": "Concept: Pathologic Stage III Gastric Cancer AJCC v8 (Gastric Cancer by AJCC v8 Pathologic Stage)", + "output": "something described as stage III includes: IIIA: (T2, N3a, M0); (T3, N2, M0); (T4a, N1, M0); (T4a, N2, M0); (T4b, N0, M0); IIIB: (T1, N3b, M0); (T2, N3b, M0); (T3, N3a, M0); (T4a, N3a, M0); (T4b, N1, M0); (T4b, N2, M0); IIIC: (T3, N3b, M0); (T4a, N3b, M0); (T4b, N3a, M0); (T4b, N3b, M0). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor penetrates the subserosal connective tissue without invasion of the visceral peritoneum or adjacent structures. T4a: Tumor invades the serosa (visceral peritoneum). T4b: Tumor invades adjacent structures/organs. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3a: Tumor with metastasis in seven to fifteen regional lymph nodes. N3b: Tumor with metastasis in sixteen or more regional lymph nodes. M0: No distant metastasis." + }, + { + "input": "Concept: Locally Advanced Bladder Urothelial Carcinoma (Locally Advanced Urothelial Carcinoma)", + "output": "Metastatic Bladder Urothelial Carcinoma described as a bladder urothelial carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes." + }, + { + "input": "Concept: Best Response (Disease Response)", + "output": "Finding described as an assessment of the most clinically favorable overall response of the disease to the therapy." + }, + { + "input": "Concept: pT2b Corpus Uteri Carcinoma TNM Finding v6 (Uterine Corpus Cancer Pathologic Primary Tumor TNM Finding v6)", + "output": "Finding described as uterine corpus cancer with invasion of the cervical stroma." + }, + { + "input": "Concept: Schaffer collateral - CA1 synapse (Body Space or Junction)", + "output": "Synapses described as a synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell." + }, + { + "input": "Concept: Unknown Primary Tumor pN3 TNM Finding v8 (Unknown Primary Tumor Pathologic Cervical Lymph Nodes TNM Finding v8)", + "output": "something described as unknown primary tumor with metastasis in a cervical lymph node larger than 6 cm in greatest dimension and ENE(-); or metastases in a single ipsilateral cervical lymph node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral, or bilateral cervical lymph nodes, any size and ENE(+) in any node." + }, + { + "input": "Concept: American College of Cardiology/American Heart Association Measure (Research or Clinical Assessment Tool)", + "output": "Intellectual Product described as an assessment utilized in the American College of Cardiology (ACC)/American Heart Association's (AHA) efforts to capture clinical data from electronic health records." + }, + { + "input": "Concept: PCAEXU (Exposure Dose Unit)", + "output": "Quantitative Concept described as the unit of measure for the challenge agent dosage form." + }, + { + "input": "Concept: SGRQ0210 (St George's Respiratory Questionnaire Past 4 Weeks Version Questionnaire Question)", + "output": "something described as st. George's Respiratory Questionnaire Past 4 Weeks Version - How would you describe your respiratory condition?" + }, + { + "input": "Concept: ANALYZER, GAS, CARBON-DIOXIDE, GASEOUS-PHASE (Medical Device)", + "output": "something described as a carbon dioxide gas analyzer is a device intended to measure the concentration of carbon dioxide in a gas mixture to aid in determining the patient's ventilatory, circulatory, and metabolic status. The device may use techniques such as chemical titration, absorption of infrared radiation, gas chromatography, or mass spectrometry." + }, + { + "input": "Concept: oxidoreductase activity, acting on other nitrogenous compounds as donors (oxidoreductase activity)", + "output": "Molecular Function described as catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." + }, + { + "input": "Concept: Vitamin C modified diet (Therapeutic or Preventive Procedure)", + "output": "something described as increase or decrease in vitamin C content of the diet. Treatment for prevention of scurvy." + }, + { + "input": "Concept: Lymph nodes of head (lymph nodes)", + "output": "Head part described as lymph node located in head region." + }, + { + "input": "Concept: RNA Polymerase III Subunit CII (Amino Acid, Peptide, or Protein)", + "output": "Enzyme described as DNA-directed RNA polymerase III subunit RPC10 (108 aa, ~12 kDa) is encoded by the human POLR3K gene. This protein is involved in innate immunity and small RNA synthesis." + }, + { + "input": "Concept: Venacavography (Diagnostic Procedure)", + "output": "angiogram described as a type of X-ray in which contrast medium is injected into a vein to show the details of the structure of the vena cava and any associated abnormalities." + }, + { + "input": "Concept: Hypomineralization of tooth (Oral lesion)", + "output": "Calcium Metabolism Disorders described as a tooth's loss of minerals, such as calcium in hydroxyapatite from the tooth matrix, caused by acidic exposure. An example of the occurrence of demineralization is in the formation of dental caries." + }, + { + "input": "Concept: glucose 1-phosphate phosphorylation (Molecular Function)", + "output": "Phosphorylation described as the process of introducing a phosphate group into glucose 1-phosphate to produce glucose bisphosphate." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Disorder, Trinucleotide Repeats, CGG, AFF2 Gene (IVD Test Reagent/Kits, Molecular Assay, Gene Disorder, Trinucleotide Repeats, CGG)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Disorder, Trinucleotide Repeats, CGG described as molecular assay reagents intended to identify CGG repeats in the fragile X mental retardation 2 (AFF2) (formerly FMR2) gene, located at chromosome Xq28. The absence of CGG repeats causes an expansion of GCC repeats, which are associated with mental retardation, including X-linked mental retardation fragile site (FRAXE)." + }, + { + "input": "Concept: Mastication, function (Gastrointestinal Process)", + "output": "Functions and Abnormal Functions of the Oral Cavity described as functions of crushing, grinding and masticating food with the back teeth (e.g. molars)." + }, + { + "input": "Concept: Dental Materials, Cement, Glass Ionomer (Biomedical or Dental Material)", + "output": "Dental Cement Material described as cement dental materials, whose main components are an aqueous polyalkenoic acid and a glass component, designed to produce a mechanical interlocking effect upon hardening inside the mouth. These cements usually consist of a powder (an acid-soluble calcium fluoro-aluminosilicate glass) and an acid liquid (e.g., tartaric, itaconic, maleic) that are mixed together in a viscous paste immediately before use, setting to a hard mass. These cements should be resistant to dissolution in oral fluids, and non-irritating to pulp and gingiva. Glass ionomer cements have anticariogenic properties due to the release of fluoride; they have proper thermal and chemical resistance in the oral environment. Metal-reinforced and resin modified glass ionomer cements are also available. Glass ionomer cements are used in dentists' offices as luting (cementing) agents, as intermediate bases under restorations and for restoring pits and fissures." + }, + { + "input": "Concept: C-SSRS Since Last Visit - Most Lethal Actual Attempt Lethality/Medical Damage (C-SSRS Since Last Visit Questionnaire Question)", + "output": "C-SSRS Since Last Visit Questionnaire Question described as columbia-Suicide Severity Rating Scale Since Last Visit - Most lethal attempt actual lethality/medical damage." + }, + { + "input": "Concept: Walking on different surfaces (Walking)", + "output": "something described as walking on sloping, uneven, or moving surfaces, such as on grass, gravel or ice and snow, or walking aboard a ship, train or other vehicle." + }, + { + "input": "Concept: vero cells (Cell)", + "output": "Epithelial Cells described as cell derived from the kidney of the African green (vervet) monkey, Cercopithecus aethiops; used primarily in virus replication studies and plaque assays." + }, + { + "input": "Concept: penberol (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as a derivative of bromoacrylic acid with cytostatic activity. Although the mechanism of action is unclear, penberol might inhibit tumor growth mediated through inhibition of the cell energetic metabolism." + }, + { + "input": "Concept: area 3 of Brodmann (Body Location or Region)", + "output": "Body Location or Region described as a cytoarchitecturally defined portion of cerebral cortex of the guenon that is located predominantly in the postcentral gyrus, but ventrally in a portion of the precentral gyrus as well. Brodmann-1909 regarded it as topographically and cytoarchitecturally homologous to area 3 of Brodmann (human). Distinctive features ( Brodmann-1905 ): compared to area 1 of Brodmann (guenon) and area 2 of Brodmann (guenon) the cortical thickness of area 3 is unusually thin, in fact, among the thinnest areas of the cerebral cortex; the cells of sublayer 3b of the external pyramidal layer (III) are smaller, plumper and more densely distributed in a tighter strip; cells of the internal granular layer (IV) are distributed more sparsely; the internal pyramidal layer (V) is relatively clear with scattered large to very large pyramid shaped ganglion cells separated by tangentially oriented fiber bundles; the multiform layer (VI) is composed of a dense population of homogeneously distributed cells such that sublayers are absent and the boundary with the subcortical white matter is distinct. According to Roberts-1963 the external granular layer (II), layer III and layer IV are not clearly demarcated from each other and are all densely packed with small cells." + }, + { + "input": "Concept: Parafoveal fixation (Finding)", + "output": "Finding described as fixation of an object in the area adjacent to the fovea." + }, + { + "input": "Concept: CONDENSER, HEAT AND MOISTURE (Household humidifier, device)", + "output": "Household humidifier, device described as a heat and moisture condenser (artificial nose) is a device intended to be positioned over a tracheotomy (a surgically created opening in the throat) or tracheal tube (a tube inserted into the trachea) to warm and humidify gases breathed in by a patient." + }, + { + "input": "Concept: JNJ63682931 (Pharmacologic Substance)", + "output": "something described as a prime cancer vaccine comprised of a genetically engineered, replication-deficient adenovirus serotype 26 (Ad26) encoding the oncogenic human papillomavirus 18 (HPV18), with potential immunostimulating and antineoplastic activities. Upon intramuscular administration of Ad26-expressing HPV18 vaccine JNJ-63682931, the adenovirus infects and expresses HPV18. The expressed proteins stimulate the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing HPV18 antigens, thereby inducing tumor cell lysis. HPV18 infection plays a key role in the development of a variety of cancers." + }, + { + "input": "Concept: Basic Helix-Loop-Helix Domain-Containing Protein USF3 (Biologically Active Substance)", + "output": "something described as basic helix-loop-helix domain-containing protein USF3 (2245 aa, ~242 kDa) is encoded by the human USF3 gene. This protein may play a role in the regulation of gene transcription." + }, + { + "input": "Concept: Skin of the Buttock (Body Part, Organ, or Organ Component)", + "output": "Skin of pelvic girdle described as the skin or integument covering the buttocks." + }, + { + "input": "Concept: PURINE-RICH ELEMENT-BINDING PROTEIN A (Gene or Genome)", + "output": "Gene or Genome described as this gene plays a regulatory role in DNA replication and transcription." + }, + { + "input": "Concept: Excessive skin wrinkling of palms and soles (Excessive wrinkling of palmar skin)", + "output": "Skin, Human described as loose, wrinkled skin of hands and feet." + }, + { + "input": "Concept: Nervous tissue (Nervous system structure)", + "output": "Tissue described as the tissue that generates and conducts electrical signals in the body. It contains the neurons." + }, + { + "input": "Concept: Gastrourology Bulking Agents, Injectable (Tissue Bulking Agents)", + "output": "Tissue Bulking Agents described as implantable liquid substances intended to be injected into urinary structure/tissues such as the urethra or ureters (e.g., the ureter wall close to the ureterovesical junction, periurethral tissue). These substances typically consist of an organic material (e.g., autologous chondrocytes) or more frequently of a biocompatible copolymer (e.g., dextranomer-hyaluronic acid) and a liquid solvent. The agent is frequently delivered using a needle attached to a catheter that is introduced through an endoscope. Urological tissue bulking agents are available for the treatment of specific disorders (e.g., vesicoureteral reflux, incontinence)." + }, + { + "input": "Concept: alkane catabolic process (cellular catabolic process)", + "output": "cellular alkane metabolic process described as the chemical reactions and pathways resulting in the breakdown of an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2." + }, + { + "input": "Concept: Recurrent Oligodendroglioma (Well Differentiated Oligodendroglioma)", + "output": "Recurrent WHO Grade II Glioma described as the reemergence of oligodendroglioma after a period of remission." + }, + { + "input": "Concept: DEK/CAN Fusion Protein (Fusion protein)", + "output": "Amino Acid, Peptide, or Protein described as a fusion protein encoded by the DEK/NUP214 fusion gene. This protein is comprised of the majority of protein DEK followed by 2/3 of the C-terminal part of the nuclear pore complex protein Nup214." + }, + { + "input": "Concept: Milliliter per Hour per Milligram per Kilogram (Quantitative Concept)", + "output": "something described as a unit of concentration equal to milliliter per hour divided by milligram per kilogram." + }, + { + "input": "Concept: PedHAL (Research or Clinical Assessment Tool)", + "output": "Intellectual Product described as an adapted version of the Haemophilia Activities List designed to assess the impact of hemophilia on a child's activities of daily living. The questionnaire consists of 53 multiple-choice items across seven domains: sitting/kneeling/standing, functions of the legs, functions of the arms, use of transportation, self-care, household tasks, and leisure activities and sports. A parent/proxy is designed for children ages 4-8) and a self-administered version for children ages 8-18." + }, + { + "input": "Concept: endocardium morphogenesis (Organ or Tissue Function)", + "output": "Organ or Tissue Function described as the process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." + }, + { + "input": "Concept: Extrusion Granulation (Laboratory Procedure)", + "output": "something described as a series of integrated steps whereby a dry powder is conditioned (by wetting or melting) to form a plasticized mass that is forced through a screen and cut into sections; integrated processing steps ultimately yield solid particles possessing characteristic dimensions and density; excludes operations used to obtain an intimate uniform mixture of the ingredients prior to being fed to the granulation equipment (e.g., convection or diffusion mixing)." + }, + { + "input": "Concept: Dry Eye, CTCAE (Eye Disorders, CTCAE)", + "output": "Eye Disorders, CTCAE described as a disorder characterized by dryness of the cornea and conjunctiva." + }, + { + "input": "Concept: Tromantadine (T [Preparations])", + "output": "something described as a cyclic amine with activity against herpes simplex virus. Tromantadine inhibits absorption of virions to cell surfaces, as well as penetration and uncoating of the virus." + }, + { + "input": "Concept: Digital Radiographic Systems, Dental (Medical Device)", + "output": "something described as digital radiographic systems usually designed for intraoral radiography. These systems include a conventional dental x-ray subsystem, either an imaging plate (computed radiography) or an intraoral detector (direct digital radiography), and a digital imaging system with a workstation and a monitor. The x-ray tube is usually located in a cylindrical tubehead mounted on an articulating arm positioned according to the view desired. Most dental radiographic system x-ray tubes have a voltage ranging from 50 to 100 kV and a current ranging from 1 to 20 mA. These systems perform image processing (e.g., zooming, multi-image viewing) and also save and retrieve images. Intraoral digital radiographic systems are used for imaging crowns and the upper third of the roots of the upper and lower teeth (bite-wing image), the full tooth structure (periapical image), or the masticating surface of premolars and molars (occlusal image)." + }, + { + "input": "Concept: Port (Manufactured Object)", + "output": "something described as an connective access point for telecommunication devices, such as modems or fax machines, for the transmission of data." + }, + { + "input": "Concept: Uneven or disproportionate growth of one body part compared to another (Growth abnormality)", + "output": "Growth abnormality described as a growth pattern that displays an abnormal difference between the left and the right side." + }, + { + "input": "Concept: Subset (Grouping)", + "output": "something described as a subdivision of a larger group with members often exhibiting similar characteristics." + }, + { + "input": "Concept: positive regulation of protein catabolic process (Cell Function)", + "output": "Cell Function described as any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." + }, + { + "input": "Concept: aspergillosis (Korean Standard Classification of Disease Version 5)", + "output": "Other mycoses described as disease condition caused by species of Aspergillus and marked by inflammatory granulomatous lesions in the skin, ear, orbit, nasal sinuses, lungs, and sometimes in the bones and meninges." + }, + { + "input": "Concept: Intra-osseous route (Musculoskeletal route)", + "output": "something described as a route that begins within the bone." + }, + { + "input": "Concept: Fibrin Modulating Agents (Molecular Mechanisms of Pharmacological Action)", + "output": "something described as agents that affect the function of FIBRIN in BLOOD COAGULATION. They used as COAGULANTS for HEMORRHAGE or ANTICOAGULANTS for THROMBOSIS." + }, + { + "input": "Concept: FIBRINOPEPTIDE A, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)", + "output": "Indicator, Reagent, or Diagnostic Aid described as a fibrinopeptide A immunological test system is a device that consists of the reagents used to measure by immunochemical techniques the fibrinopeptide A (a blood-clotting factor) in plasma and other body fluids. Measurement of fibrinopeptide A may aid in the diagnosis and treatment of certain blood-clotting disorders." + }, + { + "input": "Concept: benign skin neoplasm (Neoplasms)", + "output": "CLINICAL CLASSIFICATION OF NEOPLASMS OF THE SKIN described as a non-metastasizing neoplasm that arises from the skin. Representative examples include benign melanocytic skin nevus, acanthoma, sebaceous adenoma, sweat gland adenoma, lipoma, hemangioma, fibroma, and benign fibrous histiocytoma." + }, + { + "input": "Concept: EDAGLITAZONE SODIUM (Pharmacologic Substance)", + "output": "Thiazolidinedione Antidiabetic Agent described as the sodium salt form of edaglitazone, an agent belonging to the glitazone class of antidiabetic agents with antihyperglycemic activity. Edaglitazone also appears to lower triglyceride and free fatty acid levels." + }, + { + "input": "Concept: Tobamoviruses (Virgaviridae)", + "output": "Mosaic Viruses described as a genus of plant viruses in which the virion is a rigid filament. Transmission is by mechanical inoculation or seed. The type species is TOBACCO MOSAIC VIRUS." + }, + { + "input": "Concept: Decreased sensitivity to hypoxemia (respiratory)", + "output": "respiratory described as reduced tendency to respond to a reduced concentration of oxygen in the blood by increasing respiration." + }, + { + "input": "Concept: Stage IVA Oropharyngeal Lymphoepithelioma (Neoplastic Process)", + "output": "Stage IV Oropharyngeal Undifferentiated Carcinoma AJCC v7 described as stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Tumor with moderately advanced local disease. Tumor invades the larynx, extrinsic muscle of tongue, medial pterygoid, hard palate, or mandible. Mucosal extension to lingual surface of epiglottis from primary tumors of the base of the tongue and vallecula does not constitute invasion of larynx. T1: Tumor 2 cm or less in greatest dimension. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor measuring more than 4 centimeters in greatest dimension or extension to lingual surface of epiglottis. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Tumor with metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis." + }, + { + "input": "Concept: TMEM16 Proteins (Chloride Channels)", + "output": "Biologically Active Substance described as a family of transmembrane proteins that function primarily as calcium-activated chloride channels. Structurally, they form a homodimer where each subunit consists of eight transmembrane helices with the N and C terminals exposed to the cytosol. The regions between helices 5 and 7 may be important for ion pore formation and calcium ion binding." + }, + { + "input": "Concept: QS-FACT-B Version 4 TESTCD (Intellectual Product)", + "output": "Intellectual Product described as test codes of questionnaire questions associated with the Functional Assessment of Cancer Therapy-Breast Version 4 (FACT-B Version 4) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: Thermosome (Enzyme)", + "output": "Group II Chaperonins described as group II chaperonins found in species of ARCHAEA." + }, + { + "input": "Concept: Minimal Contact Treatment (Therapeutic procedure)", + "output": "something described as minimal interventions directed at individuals that do not involve a health care provider, such as self-help and telephone counseling." + }, + { + "input": "Concept: farnesol breakdown (farnesol metabolic process)", + "output": "antibiotic catabolic process described as the chemical reactions and pathways resulting in the breakdown of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." + }, + { + "input": "Concept: riboflavin synthase complex location (transferase complex)", + "output": "something described as an flavoprotein that catalyzes the reaction the breakdown of dimethyl(ribityl)lumazine to form riboflavin and ribitylamino-amino-dihydroxypyrimidine." + }, + { + "input": "Concept: FACT-BL Version 4 - I Feel Close to My Partner (FACT-BL Version 4 Questionnaire Question)", + "output": "something described as functional Assessment of Cancer Therapy-Bladder Version 4 (FACT-BL Version 4) Social/Family Well-Being: I feel close to my partner (or the person who is my main support)." + }, + { + "input": "Concept: Stage IIA Appendix Carcinoma AJCC v8 (Neoplastic Process)", + "output": "Neoplastic Process described as stage IIA includes: T3, N0, M0. T3: Tumor invades through the muscularis propria into the subserosa or the mesoappendix. N0: No regional lymph node metastasis. M0: No distant metastasis." + }, + { + "input": "Concept: Arthrobacter Conn and Dimmick 1947 (Approved Lists 1980) emend. Koch et al. 1995 (Gram-Positive Asporogenous Rods, Irregular)", + "output": "Bacterium described as any bacteria that is not assigned to the species level but can be assigned to the Arthrobacter genus level." + }, + { + "input": "Concept: Mimotope-P10s-PADRE Peptide Vaccine (Pharmacologic Substance)", + "output": "something described as a peptide-based vaccine containing a carbohydrate mimetic peptide (CMP) P10s fused to the pan HLA DR-binding epitope (PADRE) peptide, with immunomoadjuvant activity and potential antineoplastic activity. Upon injection of the mimotope-P10s-PADRE peptide vaccine, the P10s peptide, which mimics gangliosides and other tumor-associated carbohydrate antigens (TACA), both stimulates a cytotoxic T-lymphocyte (CTL) response towards cells expressing TACAs and induces the production of antibodies that are reactive with a broad set of TACAs. Additionally, the anti-TACA antibodies may interfere with cellular pathways involved in tumor cell survival and may induce antibody-dependent cellular cytotoxicity (ADCC) toward cells expressing TACAs. PADRE is a helper T-cell epitope that is able to increase the magnitude and duration of the CTL response. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C123381\" active clinical trials using this agent." + }, + { + "input": "Concept: Oral Docetaxel (Organic Chemical)", + "output": "something described as an oral proprietary P-glycoprotein (P-gp) pump inhibitor-based formulation containing the taxane docetaxel, a semisynthetic analogue of paclitaxel, and a P-gp pump inhibitor, with potential antineoplastic activity. Upon administration of oral docetaxel, the P-gp pump inhibitor moiety, which is not absorbed, binds to the P-gp pump in the gastrointestinal (GI) tract and prevents the P-gp pump-mediated efflux of docetaxel from cells the docetaxel has been internalized by back into the GI tract. This decreases P-gp-mediated excretion and enhances absorption of docetaxel. Upon absorption, docetaxel binds specifically to the beta-tubulin subunit of the microtubule, stabilizes tubulin and inhibits microtubule disassembly, which results in cell-cycle arrest at the G2/M phase and cell death. The P-gp pump inhibitor enhances the bioavailability of certain poorly bioavailable agents and thereby allows oral administration of those agents. P-gp, an efflux membrane transporter, plays a key role in active drug export, and prevents cellular uptake and accumulation of certain substances." + }, + { + "input": "Concept: Ba element (Metals, Alkaline Earth)", + "output": "Metals, Alkaline Earth described as a naturally occurring alkaline metalloid element with atomic symbol Ba, atomic number 56, and atomic weight 137 that is only found in combination with other elements, typically barite (barium sulfate) and witherite (barium carbonate), or chemicals. Barium is used in many industrial processes, as well as in diagnostic testing, fireworks, and pesticides. It is characterized as a silvery white or yellow to white metallic solid that is odorless. Exposure occurs by inhalation, ingestion, or contact." + }, + { + "input": "Concept: infection scrotum (Genital infection)", + "output": "Communicable Diseases described as a bacterial, fungal or viral infectious process affecting the scrotum." + }, + { + "input": "Concept: G Protein-Coupled Receptor 124 (Receptor)", + "output": "G-Protein-Coupled Receptors described as adhesion G protein-coupled receptor A2 (1338 aa, ~143 kDa) is encoded by the human ADGRA2 gene. This protein plays a role in central nervous system development and endothelial cell migration." + }, + { + "input": "Concept: diagonal sulcus (frontal lobe)", + "output": "something described as a branch from the lateral fissure into the inferior frontal gyrus of the human. Defined by dissection, it is embedded within the opercular part of the inferior frontal gyrus ( Ono-1990; Ture-1999 ). Some authors indicate that it separates the opercular part from the more caudal portion of the inferior frontal gyrus ( Duvernoy-1992 ). Branches from the lateral fissure are not found in the macaque, nor is the lateral fissure itself found in the smooth cerebral cortex of the rat or mouse ( NeuroNames )." + }, + { + "input": "Concept: histology cytopathology (Indicator)", + "output": "Indicator described as an indicator denoting whether a diagnosis was assigned based on histopathology or cytopathology." + }, + { + "input": "Concept: common; ventricle (Congenital heart disease)", + "output": "Congenital heart disease described as an umbrella term used to describe several very different complex congenital heart defects that share the same problem: the heart has only one functional ventricle (anatomically right or left or indeterminate) supplying the systemic circulation. These defects include tricuspid atresia, hypoplastic left or right heart syndrome, double outlet right ventricle, double inlet left ventricle, and other forms of single ventricle defects." + }, + { + "input": "Concept: INTENTION TREMOR (Central Nervous System)", + "output": "Kinetic tremor described as a type of kinetic tremor that occurs during target directed movement is called intention tremor. That is, an oscillatory cerebellar ataxia that tends to be absent when the limbs are inactive and during the first part of voluntary movement but worsening as the movement continues and greater precision is required (e.g., in touching a target such as the patient's nose or a physician's finger)." + }, + { + "input": "Concept: non-T, non-B, cALLa positive childhood acute lymphocytic leukemia (Neoplastic Process)", + "output": "CALLA Positive Lymphoblastic Leukemia described as a non-T, non-B, acute lymphoblastic leukemia in which the lymphoblasts are positive for the common acute lymphoblastic leukemia antigen (CALLA) occurring in children." + }, + { + "input": "Concept: Apolipoprotein J Measurement (Laboratory Procedure)", + "output": "Protein analyses NEC described as a measurement of the apolipoprotein J in a biological specimen." + }, + { + "input": "Concept: Decreased UDP-glucose 4-epimerase level in plasma (Abnormal uridine diphosphate glucose-4-epimerase level in plasma)", + "output": "something described as a decrease in uridine diphosphate glucose-4-epimerase level in plasma. Uridine diphosphate glucose-4-epimerase catalyzes the reaction: UDP-glucose = UDP-galactose. []" + }, + { + "input": "Concept: detection of reduced oxygen by chemoreceptor signaling (Cell Function)", + "output": "Cell Function described as the process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." + }, + { + "input": "Concept: CRKL (Gene or Genome)", + "output": "Signaling Pathway Gene described as this gene plays a role in cell communication and signal transduction." + }, + { + "input": "Concept: GPHN gene (Gene or Genome)", + "output": "Gene or Genome described as this gene is involved in vitamin metabolism." + }, + { + "input": "Concept: Pneumonia bacterial NOS (Other bacterial pneumonia)", + "output": "Inflammation of specific body organs described as pneumonia caused by various species of bacteria; commonly results from bronchogenic spread of infection following microaspiration of secretions." + }, + { + "input": "Concept: mitochondrial srRNA export from mitochondria (Cell Function)", + "output": "mitochondrial rRNA export from mitochondrion described as the process in which a srRNA, small subunit ribosomal ribonucleic acid, is transported from the mitochondrial matrix into the cytosol." + }, + { + "input": "Concept: Pyronine G (Organic Chemical)", + "output": "malachite green described as dye and chemical solution stains for medical purposes are mixtures of synthetic or natural dyes or nondye chemicals in solutions used in staining cells and tissues for diagnostic histopathology, cytopathology, or hematology." + }, + { + "input": "Concept: positive regulation of division septum formation involved in cell cycle cytokinesis (regulation of division septum assembly)", + "output": "Cell Function described as any process that increases the frequency, rate or extent of division septum formation. division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." + }, + { + "input": "Concept: Allergic reaction (Immune System Disorders, CTCAE)", + "output": "something described as a disorder characterized by an adverse local or general response from exposure to an allergen." + }, + { + "input": "Concept: synaptobrevin 2-SNAP-25-syntaxin-4 complex (Cell Component)", + "output": "Cell Component described as a SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 4 (or orthologs thereof)." + }, + { + "input": "Concept: up regulation of antifungal innate immune response (regulation of antifungal innate immune response)", + "output": "positive regulation of innate immune response described as any process that activates or increases the frequency, rate or extent of an antifungal innate immune response." + }, + { + "input": "Concept: T Lymphocyte Antigen Receptor alpha Chain Gene Rearrangement (Gene Rearrangement, T-Lymphocyte)", + "output": "Genetic Function described as ordered rearrangement of T-cell variable gene regions coding for the alpha-chain of antigen receptors." + }, + { + "input": "Concept: Drosera rotundifolia / sundew (Pharmacologic Substance)", + "output": "Homeopathic remedies letter D described as sundew." + }, + { + "input": "Concept: At-Risk Population (Population Group)", + "output": "Disorder Characteristics described as groups or individuals considered in danger of developing a physical, mental, emotional, behavioral, or other disorder due to adverse internal or external factors." + }, + { + "input": "Concept: striohypothalamic nucleus (Body Part, Organ, or Organ Component)", + "output": "something described as a group of cells ventral to the nucleus of stria terminalis in the anterior nucleus of the hypothalamus in the mouse ( Paxinos-2001 )." + }, + { + "input": "Concept: HYPOGALACTIA (Other disorders of breast and lactation associated with childbirth)", + "output": "Breast finding described as a condition of less than normal MILK secretion." + }, + { + "input": "Concept: Ridge (Spatial Concept)", + "output": "Other Anatomic Concept described as any long raised border or margin of a bone or tooth or membrane." + }, + { + "input": "Concept: agents hemostatic (Agent Affecting Blood or Body Fluid)", + "output": "Cardiovascular equipment described as an agent that promotes hemostasis." + }, + { + "input": "Concept: Posterior Horn Neurons (Spinal Cord)", + "output": "Body Part, Organ, or Organ Component described as neurons in the SPINAL CORD DORSAL HORN whose cell bodies and processes are confined entirely to the CENTRAL NERVOUS SYSTEM. They receive collateral or direct terminations of dorsal root fibers. They send their axons either directly to ANTERIOR HORN CELLS or to the WHITE MATTER ascending and descending longitudinal fibers." + }, + { + "input": "Concept: phytol metabolism (Molecular Function)", + "output": "primary alcohol metabolic process described as the chemical reactions and pathways involving phytol, (2E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol." + }, + { + "input": "Concept: Community Genomics (Bio-Informatics)", + "output": "something described as the systematic study of the GENOMES of assemblages of organisms." + }, + { + "input": "Concept: benign neoplasm hemangiopericytoma (hemangiopericytoma)", + "output": "Benign neoplasm of blood vessel of head described as a benign or malignant hemangiopericytoma arising from the orbit." + }, + { + "input": "Concept: Oral Conc (Concentrate Dosage Form)", + "output": "Biomedical or Dental Material described as a concentrate that usually requires dilution prior to oral administration." + }, + { + "input": "Concept: L-ascorbate 6-phosphate lactonase activity (Molecular Function)", + "output": "something described as catalysis of the reaction: L-ascorbate 6-phosphate + H2O = 3-keto-L-gulonate 6-phosphate." + }, + { + "input": "Concept: PENICILLINS (ANTIBACTERIALS FOR SYSTEMIC USE)", + "output": "Monobactams described as a group of antibiotics that contain 6-aminopenicillanic acid with a side chain attached to the 6-amino group. The penicillin nucleus is the chief structural requirement for biological activity. The side-chain structure determines many of the antibacterial and pharmacological characteristics." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, GPR143 (Medical Device)", + "output": "something described as molecular assay reagents intended to identify mutations in the ocular albinism GPR143 (formerly OA1) gene, located at chromosome Xp22.3, which encodes for a protein that is involved in the coloring (pigmentation) of the eyes and skin. Mutations at this locus have been identified in patients with congenital (newborn) ocular albinism type 1 (also known as Nettleship-Falls type ocular albinism)." + }, + { + "input": "Concept: bsk male horm.prfle ea.tst (Laboratory Procedure)", + "output": "Laboratory Procedure described as providing a basic analysis of a male client/patient's specimen sample to assess his testosterone levels. Service is billed per test." + }, + { + "input": "Concept: Alkylated Estrogenic Steroids (Pharmacologic Substance)", + "output": "Estradiol Congeners described as estrogenic STEROIDS with aliphatic hydrocarbon chain substitution on C17 or other position. 17-alpha-ALKYLATION renders the molecule more stable, resistant to metabolic degradation, and improves oral efficacy. Examples of synthetic alkyl estrogens include ETHINYL ESTRADIOL and MESTRANOL. Substitutions at other sites generates antiestrogenic and cytotoxic properties." + }, + { + "input": "Concept: Taking care of animals (Caring for household objects)", + "output": "something described as taking care of domestic animals and pets, such as by feeding, cleaning, grooming and exercising pets; watching over the health of animals or pets; planning for the care of animals or pets in one's absence." + }, + { + "input": "Concept: negative regulation of spore-bearing organ development (regulation of spore-bearing organ development)", + "output": "negative regulation of developmental process described as any process that stops, prevents, or reduces the frequency, rate or extent of spore-bearing organ development, a process in which hyphae grow into special aggregates called fruiting bodies that produce new spores." + }, + { + "input": "Concept: Serine and Arginine Rich Splicing Factor 2 Gene Mutation (Gene Mutant)", + "output": "Gene Mutant described as a change in the nucleotide sequence of the SRSF2 gene." + }, + { + "input": "Concept: myosin III complex location (unconventional myosin complex)", + "output": "Cell Component described as a myosin complex containing a class III myosin heavy chain and associated light chains; myosin III is monomeric myosin that serves as a link between the cytoskeleton and the signaling complex involved in phototransduction, and differs from all other myosins in having an N-terminal kinase domain." + }, + { + "input": "Concept: YTTRIUM Y-90 EPRATUZUMAB TETRAXETAN (Amino Acid, Peptide, or Protein)", + "output": "Radioimmunoconjugates described as a radioimmunotherapeutic humanized murine monoclonal antibody (LL2) directed against the CD22 pan-B-cell antigen and chelated to the radioisotope yttrium-90 (Y 90). Y 90 humanized monoclonal antibody LL2 binds to tumor cells expressing CD22, delivering a cytotoxic dose of beta radiation." + }, + { + "input": "Concept: HLH3 Gene Mutation (Gene Mutant)", + "output": "Cell or Molecular Dysfunction described as a change in the nucleotide sequence of the UNC13D gene." + }, + { + "input": "Concept: carcinoma ex pleomorphic adenoma of salivary gland (Salivary gland carcinoma)", + "output": "something described as a carcinoma that arises from a pleomorphic adenoma in the salivary glands. It usually originates in the parotid gland. Patients usually present with a history of a long-standing tumor mass which grew rapidly in the past few months. Patients with non-invasive or minimally invasive carcinoma have an excellent prognosis. In cases where there is invasion of the surrounding tissues, the clinical course is aggressive." + }, + { + "input": "Concept: cobicistat-darunavir (Anti-HIV Agents, Protease Inhibitors)", + "output": "Anti-HIV Agents, Protease Inhibitors described as a fixed combination of darunavir, an inhibitor of the human immunodeficiency virus (HIV) protease; and cobicistat, a cytochrome P450 3A (CYP3A) inhibitor that may be used to treat HIV infection. Upon oral administration, darunavir binds to and inhibits the dimerization and catalytic activity of the HIV aspartyl protease. This inhibits the cleavage of HIV-encoded Gag and Gag-Pol polyproteins in virus-infected cells, which prevents the formation of mature infectious virions. Cobicistat inhibits CYP3A, thereby limiting the metabolism of darunavir and increases its systemic exposure." + }, + { + "input": "Concept: Pyothorax-Associated Lymphoma (Neoplastic Process)", + "output": "Neoplastic Process described as an aggressive diffuse large B-cell lymphoma arising in the pleural cavity of patients with a history of long standing pyothorax. Patients present with chest and back pain, fever, productive cough, dyspnea, and hemoptysis." + }, + { + "input": "Concept: undef.trxn mdlty narr req'd (Therapeutic or Preventive Procedure)", + "output": "something described as any elsewhere undefined traction modality, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com." + }, + { + "input": "Concept: Hereditary thrombocythaemia (Inherited platelet disorder)", + "output": "something described as a type of thrombocytosis, a sustained elevation of platelet numbers, which affects the platelet/megakaryocyte lineage and may create a tendency for thrombosis and hemorrhage but does not cause myeloproliferation. The disease usually presents at birth but can be discovered at any time during life and thus can affect all ages. Familial thrombocytosis is caused by germline mutations in the THPO gene (3q26.3-q27) or in the MPL (MPL S505N) gene (1p34)." + }, + { + "input": "Concept: Clinical Study Activity Relationship Comment (Published Comment)", + "output": "Intellectual Product described as an additional description of the relationship between the clinical study activities specified in a study protocol. It might refer to a temporal or sequential relationship, or indicate the possibility of performing a particular type of activity as a substitute for another one." + }, + { + "input": "Concept: Acetaminophen/Phenylephrine-containing Formulation (Pharmacologic Substance)", + "output": "Organic Chemical described as a commercial combination preparation, by Johnson and Johnson, containing acetaminophen and pseudoephedrine hydrochloride used to relieve symptoms of cold and flu. Acetaminophen exerts analgesic and antipyretic actions by inhibiting prostaglandin synthesis. Pseudoephedrine hydrochloride, a sympathomimetic agent, acts as a decongestant by inducing vasoconstriction mediated through alpha-adrenergic receptors, thereby reducing blood flow which decreases swelling and prevents and relieves nasal and sinus congestion." + }, + { + "input": "Concept: polygraphs (manufactured apparatus)", + "output": "Recorders, Physiologic described as multichannel physiologic graphical recorders designed for the simultaneous recording of instantaneous values and/or variations of a number of different physiologic parameters (e.g., electrocardiogram; electroencephalogram; temperature, respiration, blood pressure), usually under conditions of physical or mental stress. Dedicated multichannel graphical recorders are available for recording a variety of parameters used in different types of assessments (e.g., polysomnography); the term is frequently associated with polygraphs intended to assess the truth of people's statements (i.e., lie detectors)." + }, + { + "input": "Concept: Herbal Material (Unprocessed) Dosage Form Category (Biomedical or Dental Material)", + "output": "Basic Dosage Form Category described as a type of solid pharmaceutical dose form consisting of whole, broken or fragmented plants or parts of plants (including algae, fungi, lichen) in an unprocessed state, and which may be dried or fresh." + }, + { + "input": "Concept: Thin uvula (Finding)", + "output": "something described as decreased width of the uvula." + }, + { + "input": "Concept: Vaginal Rhabdomyoma (Neoplastic Process)", + "output": "Benign neoplasm vagina described as a rare benign polypoid skeletal muscle neoplasm arising from the vagina. It is characterized by the presence of round striated muscle cells and strap-like skeletal muscle cells, and vascular space formations within a fibrous and myxoid stroma." + }, + { + "input": "Concept: Neural crest cell group (Cells)", + "output": "something described as an embryonic cell that separates from the neural plate during formation of the neural tube and migrates to give several different lineages of adult cells: the spinal and autonomic ganglia, the glial cells of the peripheral nervous system, and nonneuronal cells, such as chromaffin cells, melanocytes and some haemopoietic cells." + }, + { + "input": "Concept: Hematopoiesis Induction (Cell Function)", + "output": "Hematopoiesis described as hematopoiesis Induction involves initiation of a process of blood formation; more specifically formation of blood cells that are all derived from hematopoietic stem cells." + }, + { + "input": "Concept: zincum aceticum/zinc acetate (Homeopathic remedies letter Z)", + "output": "Pharmacologic Substance described as acetate of zinc." + }, + { + "input": "Concept: Lice (Fungi, Parasites, Insects and Animals)", + "output": "something described as small, wingless, parasitic insects; though exact taxonomy is still controversial, they can be grouped in the orders Anoplura (sucking lice), Mallophaga (biting lice), and Rhynchophthirina (elephant-lice)." + }, + { + "input": "Concept: Neuron Conduction Induction (Neurologic Effect)", + "output": "Neurologic Effect described as neuron Conduction Induction involves initiation of activities that propagate the transfer of the electrochemical action potential process along nerve fibers away from the cell body." + }, + { + "input": "Concept: ADNI AVLT - List A Recall 6 (After B) Word 9 (Intellectual Product)", + "output": "something described as auditory Verbal Learning Test Version A - List A, Recall 6 (after B Recall), Word 9." + }, + { + "input": "Concept: Metal (Inorganic Chemical)", + "output": "Inorganic Chemicals described as may include alloys." + }, + { + "input": "Concept: Medulloblastoma, SHH-activated and TP53-wildtype (Medulloblastoma, SHH-Activated)", + "output": "Medulloblastoma, SHH-Activated described as medulloblastoma associated with activation of the sonic hedgehog (SHH) pathway and the absence of TP53 mutations." + }, + { + "input": "Concept: ENTEROBACTERIA PHAGE P 002 (Peduovirus)", + "output": "Myoviridae described as a species of temperate bacteriophage in the genus P2-like viruses, family MYOVIRIDAE, which infects E. coli. It consists of linear double-stranded DNA with 19-base sticky ends." + }, + { + "input": "Concept: Nasopharyngeal Cancer pN1 TNM Finding v6 (Finding)", + "output": "Finding described as nasopharyngeal cancer with unilateral metastasis to one or more lymph nodes, 6 cm or less in greatest dimension, above the supraclavicular fossa. Midline nodes are considered ipsilateral nodes." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, UBE3A (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)", + "output": "something described as molecular assay reagents intended to identify deletions or duplications of the ubiquitin protein ligase E3A (UBE3A) gene, located at chromosome 15q11.2, which encodes the protein ubiquitin-protein ligase E3A. Genetic variants at this locus have been associated with Angelman syndrome." + }, + { + "input": "Concept: pulmonary valve formation (heart valve formation)", + "output": "something described as the developmental process pertaining to the initial formation of the pulmonary valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." + }, + { + "input": "Concept: regulation of hydrogen peroxide biosynthesis (regulation of cellular biosynthetic process)", + "output": "Molecular Function described as any process that modulates the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." + }, + { + "input": "Concept: Spiritual nurse diet modification and/or food preparation each 15 minutes (Spiritual nursing care)", + "output": "Health Care Activity described as preparing food and/or modifying a patient's diet while remaining consistent with his or her religious beliefs. Service is billed in 15-minute increments." + }, + { + "input": "Concept: infection cranial nerve (Cranial nerve disorders NEC)", + "output": "Central nervous system and spinal infections described as an infectious process affecting a cranial nerve." + }, + { + "input": "Concept: GRAPEFRUIT (Fruit, Citrus)", + "output": "something described as the sour to semi-sweet fruit of Citrus x paradisi. Grapefruit can have interactions with drugs, often increasing the effective potency of compounds." + }, + { + "input": "Concept: CSS10-Preparatory Acts/Behavior-P3M (Intellectual Product)", + "output": "C-SSRS Pediatric Cognitively Impaired Lifetime Recent Questionnaire Question described as columbia-Suicide Severity Rating Scale Pediatric/Cognitively Impaired Lifetime/Recent - Have you done anything to get ready to make yourself not alive anymore (to end your life or kill yourself) - like giving things away, writing a goodbye note, getting things you need to kill yourself? (Past 3 Months)." + }, + { + "input": "Concept: patch transdermal (Equipment and Supplies)", + "output": "Transdermal Route of Drug Administration described as flexible single-dose preparation intended to be applied to the unbroken skin to obtain a local effect by penetration of the active substance(s) into the skin." + }, + { + "input": "Concept: Life Support (GENERAL MEDICAL CARDIOVASCULAR PROCEDURES INCLUDING CARDIOVERSIONS)", + "output": "GENERAL MEDICAL CARDIOVASCULAR PROCEDURES INCLUDING CARDIOVERSIONS described as any medical procedure used to sustain the life of a patient in critical condition." + }, + { + "input": "Concept: Flutamide (Androgen Receptor Inhibitor [EPC])", + "output": "Synthetic antiandrogen, NOS described as an antiandrogen with about the same potency as cyproterone in rodent and canine species." + }, + { + "input": "Concept: Metastatic/Recurrent (Qualitative Concept)", + "output": "something described as a tumor that has spread to anatomic sites away from the original site of growth or has reappeared in any anatomic site. The vast majority of such tumors are malignant." + }, + { + "input": "Concept: trauma release ea.15min (Therapeutic or Preventive Procedure)", + "output": "Therapeutic or Preventive Procedure described as using therapeutic movement and breath work to release a client's psychoemotional trauma and/or pain. Service is billed in 15-minute increments." + }, + { + "input": "Concept: Clinical Stage IV Gastric Cancer AJCC v8 (Neoplastic Process)", + "output": "something described as stage IV includes: IVA: (T4b, Any N, M0); IVB: (Any T, Any N, M1). T4b: Tumor invades adjacent structures/organs. M0: No distant metastasis. M1: Distant metastasis." + }, + { + "input": "Concept: B2G1GGAB (Laboratory Procedure)", + "output": "Immunologic Tests described as a measurement of the Beta-2 glycoprotein 1 IgG antibodies in a biological specimen." + }, + { + "input": "Concept: Diabetes Distress Scale for Parents of Teens with Type 1 Diabetes Questionnaire Test Name (Intellectual Product)", + "output": "CDISC Questionnaire Terminology described as test names of questionnaire questions associated with the Diabetes Distress Scale for Parents of Teens with Type 1 Diabetes (PARENT-DDS) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: Nitric Acid Measurement (Measurement of substance)", + "output": "biochemical test described as a measurement of the nitrate in a biological specimen." + }, + { + "input": "Concept: Infusion Systems, Intravenous Fluid, Closed-Loop (Infusion Pump)", + "output": "something described as infusion systems designed to maintain a patient's intravascular fluid volume by automatically infusing intravenously a volume of fluid (e.g., isotonic saline) matched to the patient's urinary output. These infusion systems consist of an infusion pump console and a tubing set for saline solution infusion and urine collection. Following an initial saline bolus, the collection set captures urine excreted by the patient, and the volume excreted is measured by a scale integrated with the pump console. In response to urine excretion, the pump console administers to the patient in real-time a volume of saline solution equal to that excreted as urine. These infusion systems may be used in intravenous hydration therapy procedures to reduce the risk of over- or under-hydration relative to standard infusion. In particular, these systems may be used during renal protective procedures that maintain high urine throughput (greater than or equal to 300 mL/h) in order to increase clearance of toxic substances (e.g., contrast media) from the kidneys." + }, + { + "input": "Concept: S100Z gene (Gene or Genome)", + "output": "Gene or Genome described as this gene plays a role in calcium ion binding." + }, + { + "input": "Concept: Adolescent psychiatry (Biomedical Occupation or Discipline)", + "output": "Treatment (General) described as the medical science that deals with the origin, diagnosis, prevention, and treatment of mental disorders in individuals 13-18 years." + }, + { + "input": "Concept: peptidyl-S-myristoyl-L-cysteine formation from peptidyl-cysteine (Molecular Function)", + "output": "peptidyl-cysteine modification described as the modification of peptidyl-cysteine to form peptidyl-S-myristoyl-L-cysteine." + }, + { + "input": "Concept: Clear About Which Risks and Side Effects Matter Most (Intellectual Product)", + "output": "Intellectual Product described as a question about an individual's assessment of whether they are or were clear about which risks and side effects matter most." + }, + { + "input": "Concept: luteal cell differentiation (Cell Differentiation process)", + "output": "something described as the process in which a relatively unspecialized cell acquires the specialized features of a luteal cell. Large luteal cells develop from granulosa cells. Small luteal cells develop from theca cells." + }, + { + "input": "Concept: ELF (Gene or Genome)", + "output": "Cytoskeletal Gene described as this gene plays a role in actin binding, cell shape and calcium-dependent transport." + }, + { + "input": "Concept: angiogenin-placental ribonuclease inhibitor complex (protein-containing complex)", + "output": "Cell Component described as a stable heterodimer of angiogenin and placental ribonuclease inhibitor; interaction between angiogenin and PRI prevents angiogenin binding to its receptor to stimulate angiogenesis." + }, + { + "input": "Concept: needle aspiration (Medical Device)", + "output": "Needle device described as needles designed for aspirating fluids from cavities, cysts, and wounds. These devices typically consist of long, hollow needles, either with sharp or blunt tips, and opposite ends that include a female Luer slip or Luer-lock hub for connection to a syringe or other collection/aspiration device." + }, + { + "input": "Concept: epidemiologic methods (Research Activity)", + "output": "Investigative Techniques described as epidemiological methods involve sophisticated statistics and higher mathematics. These methods allow epidemiologists to address issues like non-experimental studies of mechanistic questions in disease etiology, including studies of the impact of the social position of individuals in different social contexts." + }, + { + "input": "Concept: Bevacizumab-Everolimus (Therapeutic or Preventive Procedure)", + "output": "Regimen Used to Treat Malignant Renal Neoplasm described as a regimen consisting of bevacizumab and everolimus that can be used for the treatment of kidney cancer." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Serology, Virus, Influenza A, IgG Antibody (IVD Test Reagent/Kits, Serology, Virus, Influenza A, Antibody)", + "output": "IVD Test Reagent/Kits, Serology, Virus, Influenza A, Antibody described as serology reagents intended to detect immunoglobulin G (IgG) antibodies to Influenza virus type A, a single-stranded RNA virus of the family Orthomyxoviridae. Influenza A viruses may cause human influenza, a disease characterized by sudden onset of high fever, myalgia, headache, severe malaise, nonproductive cough, sore throat, and rhinitis. The subtypes of influenza known to affect humans are H1N1, H1N2, and H3N2; other subtypes such as H5 and H7 (i.e., avian influenza) affect birds but may occasionally affect humans." + }, + { + "input": "Concept: RNA biosynthesis (nucleic acid biosynthesis)", + "output": "Molecular Function described as used to denote the transcription of DNA into RNA. The biochemical machinery includes sequence-specific DNA binding proteins that directly act in the regulation of the transcription process, other protein factors that participate in the assembly of the transcription complex, and RNA polymerase." + }, + { + "input": "Concept: Tyrosine-Protein Kinase Receptor EHK-1 (Receptor)", + "output": "something described as ephrin type-A receptor 5 (1037 aa, ~115 kDa) is encoded by the human EPHA5 gene. This protein is involved in tyrosine phosphorylation, cell-cell signaling and central nervous system development." + }, + { + "input": "Concept: L-cysteine:tRNACys ligase (aminoacyl-tRNA ligase activity)", + "output": "something described as catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)." + }, + { + "input": "Concept: Clinical Trials, Phase II as Topic (Clinical Study by Phase)", + "output": "something described as a clinical research protocol designed to study a biomedical or behavioral intervention in a larger group of people (several hundred), to evaluate the drug's effectiveness for a particular indication in patients with the disease or condition under study, and to determine the common short-term side effects and risks associated with the intervention." + }, + { + "input": "Concept: Vacutainer Tubes, Blood Collection (Blood tube)", + "output": "Tubes, Blood Collection described as blood-collection tubes with a relative vacuum in their interior designed to store a predetermined volume of blood sample drawn from a venipuncture through a blood-collection set. These devices are typically plastic or glass tubes of which the working end is presealed after obtaining a relative vacuum. They are usually connected using an adapter to a needle (that may include a Luer lock), which in turn punctures the stopper of the blood-collection set. Evacuated blood-collection tubes frequently contain a substance appropriate to inhibit or enhance coagulation according to the intended use of the blood sample (e.g., heparin for chemical analysis, sodium citrate for plasma coagulation); the tube caps are usually color coded accordingly." + }, + { + "input": "Concept: cocaine biosynthetic process (aromatic compound biosynthetic process)", + "output": "tropane alkaloid biosynthetic process described as the chemical reactions and pathways resulting in the formation of cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic." + }, + { + "input": "Concept: Monoclonal immunoglobulin (GENERAL ANTIBODIES AND RELATED PHENOMENA)", + "output": "Immunosuppressive Agents described as a type of protein made in the laboratory that can bind to substances in the body, including tumor cells. There are many kinds of monoclonal antibodies. Each monoclonal antibody is made to find one substance. Monoclonal antibodies are being used to treat some types of cancer and are being studied in the treatment of other types. They can be used alone or to carry drugs, toxins, or radioactive materials directly to a tumor." + }, + { + "input": "Concept: Neurotrophic Tyrosine Kinase, Receptor Related 3 Protein (discoidin receptor)", + "output": "Amino Acid, Peptide, or Protein described as a discoidin domain receptor for FIBRILLAR COLLAGEN and non-fibrillar COLLAGEN TYPE X. It functions in many cellular and developmental processes that include remodeling of the EXTRACELLULAR MATRIX; CELL MIGRATION; CELL DIFFERENTIATION; and CELL PROLIFERATION; as well as OSTEOGENESIS and the maturation of CHONDROCYTES." + }, + { + "input": "Concept: arachidonic acid metabolic process (unsaturated fatty acid metabolic process)", + "output": "something described as the chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer." + }, + { + "input": "Concept: folate and derivative biosynthetic process (pteridine-containing compound biosynthetic process)", + "output": "coenzyme biosynthetic process described as the chemical reactions and pathways resulting in the formation of folic acid and its derivatives." + }, + { + "input": "Concept: Melanoma Antigen Family A, 3 wt Allele (MAGEA3 gene)", + "output": "Gene or Genome described as human MAGEA3 wild-type allele is located in the vicinity of Xq28 and is approximately 4 kb in length. This allele, which encodes melanoma-associated antigen 3 protein, plays a role in the regulation of tumor cell recognition by killer T lymphocytes and may be involved in embryonic development." + }, + { + "input": "Concept: Mizuo phenomenon (Finding)", + "output": "something described as change in the color of the fundus from red in the dark-adapted state to golden immediately or shortly after the onset of the light. The color of the fundus reflex in the light adapted state has also been described as golden-yellow, gray-white, and yellow-white. This reflex can appear either homogeneous or in streaks in the fundus. The retinal vessels appear to be protruding in contrast to the radiant background. Dark adaptation leads to disappearance of the unusual fundus coloration [Digital Journal of Ophthalmology 2008; Volume 14, Number 14]." + }, + { + "input": "Concept: Isocitrate Dehydrogenase 1 (NADP+), Soluble c.394C>T (Cell or Molecular Dysfunction)", + "output": "IDH1 Gene Mutation described as a nucleotide substitution at position 394 of the coding sequence of the IDH1 gene where cytosine has been mutated to thymine." + }, + { + "input": "Concept: CD246 c.3733T>A (Cell or Molecular Dysfunction)", + "output": "something described as a nucleotide substitution at position 3733 of the coding sequence of the ALK gene where thymine has been mutated to adenine." + }, + { + "input": "Concept: VBU (Dermatographic urticaria)", + "output": "Dermatographic urticaria described as urticaria in response to dermal vibration, with coincident degranulation of mast cells and increased histamine levels in serum." + }, + { + "input": "Concept: S-methylmethionine cycle (Molecular Function)", + "output": "Molecular Function described as a cyclic series of interconversions involving S-methyl-L-methionine, S-adenosyl-L-homocysteine, S-adenosyl-L-methionine, L-homocysteine, and L-methionine. Converts the methionine group of adenosylmethionine back to free methionine, and may serve regulate the cellular adenosylmethionine level." + }, + { + "input": "Concept: nucleosomal DNA binding (nucleosome binding)", + "output": "Genetic Function described as interacting selectively and non-covalently with the DNA portion of a nucleosome." + }, + { + "input": "Concept: SL-701 (Dendritic Cell Vaccine)", + "output": "Dendritic Cell Vaccine described as a cell-based cancer vaccine comprised of dendritic cells (DCs) pulsed with various, synthetic glioma-associated antigen (GAA) peptides, with potential antineoplastic activity. Upon subcutaneous administration, the glioma-associated peptide-loaded DC vaccine SL-701 exposes the immune system to various GAA peptides. This may stimulate both anti-tumoral cytotoxic T lymphocyte (CTL) and antibody responses against the GAA-expressing glioma cells, which may result in tumor cell lysis." + }, + { + "input": "Concept: Proliferating Erythroid/Total Cells (Blood Cell Count Ratio Measurement)", + "output": "something described as a relative measurement (ratio or percentage) of the proliferating erythroid cells to total cells in a biological specimen." + }, + { + "input": "Concept: Acute inflammation of sinus (Acute sinusitis)", + "output": "Acute upper respiratory infection described as sinusitis lasting less than or equal to thirty days." + }, + { + "input": "Concept: Magnesium-rich Mineral Water (Food)", + "output": "Food described as carbonated, iron-depleted mineral water from the French springs of Beauregard-Vendon (Rouzat) containing very high amounts of the mineral magnesium as well as sodium, calcium, potassium, bicarbonate, sulfate, chloride and nitrate, that can be used for supplemental purposes and can potentially be used to treat hypomagnesemia. Magnesium, an electrolyte, plays a key role as a cofactor in multiple enzymatic reactions and for muscle and nervous system functioning. Hypomagnesemia may manifest as asthenia, cramps, muscle weakness, fatigue, and mood disorders. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C148542\" active clinical trials using this agent." + }, + { + "input": "Concept: phosphoglycosylation (Molecular Function)", + "output": "something described as the glycosylation of peptidyl-amino acids through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues." + }, + { + "input": "Concept: Myotonia, intellectual disability, skeletal anomalies syndrome (Disease or Syndrome)", + "output": "Multiple system malformation syndrome described as a rare genetic myotonic syndrome characterized by childhood onset of progressive and severe myotonia (with generalized muscular hypertrophy and progressive impairment of gait) short stature, skeletal abnormalities (including pectus carinatum, short, wedge-shaped thoracolumbar vertebrae, kyphoscoliosis, genu valgum, irregular femoral epiphyses) and mild to moderate intellectual deficiency. Facial dysmorphism and joint limitation are not associated. There have been no further descriptions in the literature since 1984." + }, + { + "input": "Concept: OABQ02 (Clinical or Research Assessment Questionnaire)", + "output": "something described as the Overactive Bladder Questionnaire Short Form (OAB-q Short Form) (Karin S. Coyne, Christine L. Thompson, Jin-Shei Lai, and Chris C. Sexton. An Overactive Bladder Symptom and Health-Related Quality of Life Short-Form: Validation of the OAB-q SF. Neurourology and Urodynamics 34:255-263, 2015)." + }, + { + "input": "Concept: TLCPP (Pulmonary function tests)", + "output": "Pulmonary function tests described as the total volume of air in the lungs after maximum inhalation as a proportion of the predicted normal value." + }, + { + "input": "Concept: HIV Technical Specifications Guidance v1.0 (FDA Technical Specification Name and Version)", + "output": "something described as version 1.0 of the FDA HIV Technical Specifications Guidance." + }, + { + "input": "Concept: Alternative Prion Protein (Amino Acid, Peptide, or Protein)", + "output": "something described as an overlapping open reading frame within the PRNP gene that encodes a protein which is smaller and structurally unrelated to major prion protein." + }, + { + "input": "Concept: CRQ02-Energy (CRQ-SAS Follow-Up Administration Version Questionnaire Question)", + "output": "CRQ-SAS Follow-Up Administration Version Questionnaire Question described as chronic Respiratory Questionnaire Self-Administered Standardized Format Follow-Up Administration Version Questionnaire (CRQ-SAS Follow-Up Administration Version) How much energy have you had in the last 2 weeks?" + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Infection, Fungi/Yeast, Cryptococcus neoformans, rRNA (IVD Test Reagent/Kits, Molecular Assay, Infection, Fungi/Yeast, Cryptococcus neoformans)", + "output": "Medical Device described as molecular assay reagents intended to identify Cryptococcus neoformans, a yeast-like species of imperfect fungi of the family Cryptococcaceae, by detecting specific genetic information of the ribosomal ribonucleic acid (rRNA) of the target microorganism. These fungi may cause cryptococcosis, a mycotic infection of the brain and meninges, which may also involve other organs such as the skin and lungs. The disease may progress by invading the central nervous system, lungs, liver, and spleen of immunocompromised patients." + }, + { + "input": "Concept: IBM (Myositis)", + "output": "Inflammatory and immune myopathies, not elsewhere classified described as progressive myopathies characterized by the presence of inclusion bodies on muscle biopsy. Sporadic and hereditary forms have been described. The sporadic form is an acquired, adult-onset inflammatory vacuolar myopathy affecting proximal and distal muscles. Familial forms usually begin in childhood and lack inflammatory changes. Both forms feature intracytoplasmic and intranuclear inclusions in muscle tissue." + }, + { + "input": "Concept: Peri-implant mucositis (Disorder of dental prosthesis)", + "output": "Infection associated with device described as presence of inflammation in the soft tissue surrounding a dental implant without signs of any loss of supporting bone" + }, + { + "input": "Concept: CD158d Antigens (Amino Acid, Peptide, or Protein)", + "output": "CD Antigens described as a KIR receptor that has specificity for HLA-G antigen. It contains D0 and D2 extracellular immunoglobulin-like domains and a long cytoplasmic tail." + }, + { + "input": "Concept: 10^3.{RNA copies}/ml (Quantitative Concept)", + "output": "cpy/mL described as a unit of measurement equal to 10 to the third power of the number of ribonucleic acid (RNA) copies per unit of volume equal to one milliliter." + }, + { + "input": "Concept: Immunoglobulin G4-kappa, Anti-(Homo sapiens KLRC1 (Killer Cell Lectin-like Receptor Subfamily C Member 1, NKG2-a, NKG2a, CD159A, CD94)), Humanized Monoclonal Antibody (Immunologic Factor)", + "output": "Monoclonal Antibodies described as a humanized immunoglobulin G4 (IgG4) monoclonal antibody against the human natural killer (NK) and T-lymphocyte cell checkpoint inhibitor killer cell lectin-like receptor subfamily C member 1 (NKG2A), with potential antineoplastic activity. Upon administration, monalizumab binds to NKG2A and prevents the binding of NKG2A to its ligand human leukocyte antigen-E (HLA-E), which is overexpressed on tumor cells. This blocks the HLA-E-mediated inhibition of NKG2A-positive infiltrating NK and cytotoxic T-lymphocytes (CTLs) and induces a NK and CTL-mediated immune response against the cancer cells leading to their destruction. Human NKG2A, an inhibitory cell surface receptor covalently bound to CD94, is expressed by NK cells and CTLs. Stimulation of the CD94/NKG2A complex inhibits the cytotoxic activity of these cells. HLA-E, a nonclassical HLA class Ib molecule, is often overexpressed on tumor cells and is associated with poor prognosis." + }, + { + "input": "Concept: DAGK (Gene or Genome)", + "output": "DGKA gene described as human DGKA wild-type allele is located in the vicinity of 12q13.3 and is approximately 27 kb in length. This allele, which encodes diacylglycerol kinase alpha protein, plays a role in lipid phosphorylation and the attenuation of second messenger signaling." + }, + { + "input": "Concept: synopsis (Summary)", + "output": "Intellectual Product described as brief overview prepared at the conclusion of a study as a routine part of a regulatory submission, summarizing the study plan and results; includes numerical summary of efficacy and safety results, study objective, criteria for inclusion, methodology, etc." + }, + { + "input": "Concept: Trifluralin (toluene)", + "output": "Hazardous or Poisonous Substance described as a microtubule-disrupting pre-emergence herbicide." + }, + { + "input": "Concept: Methylcholanthrene (Organic Chemical)", + "output": "Hazardous or Poisonous Substance described as a carcinogen that is often used in experimental cancer studies." + }, + { + "input": "Concept: Risk for impaired attachment (Finding)", + "output": "something described as susceptible to disruption of the interactive process between parent or significant other and child that fosters the development of a protective and nurturing reciprocal relationship." + }, + { + "input": "Concept: Unit of Electric Flux Density (Quantitative Concept)", + "output": "something described as a unit for measurement of vector-valued field that appears in Maxwell's equations." + }, + { + "input": "Concept: basidiospore formation (sexual sporulation resulting in formation of a cellular spore)", + "output": "sexual sporulation resulting in formation of a cellular spore described as the process in which spores form outside a specialized end cell known as a basidium. Basidia are characteristic of the basidiomycete fungi (phylum Basidiomycota), and give rise to spores that each contain a haploid nucleus that is the product of meiosis. The spores are usually attached to the basidium by short spikes called sterigmata (singular: sterigma). In most basidiomycetes there are four sterigmata (and four spores) to a basidium." + }, + { + "input": "Concept: Electroencephalography Electronic Recording Processors (Medical Device)", + "output": "something described as data processors designed to acquire and process digital data obtained from electroencephalographic signals that were previously electronically recorded (e.g., using a flash card). Data is transferred from the electroencephalographic recorder to the processor (also known as a electroencephalogram scanner) for quantification, processing, display, and storage using dedicated software; the processor may also generate reports. Due to the large amount of data recorded, scanning techniques are used to decrease review time. Electroencephalography processors are used with electronic continuous and event recorders; they are intended mainly for the detection of cerebral problems, such as temporary abnormalities (e.g., seizures), and sleep disorders) and to check the progress of therapy (e.g., antiepileptic drugs) over a relatively long period of time (e.g., 24 to 72 hours)." + }, + { + "input": "Concept: cardiac jogging (Organ or Tissue Function)", + "output": "embryonic heart tube morphogenesis described as the morphogenetic process in which the heart cone is displaced to the left with respect to the vector of the anterior-posterior axis." + }, + { + "input": "Concept: Stage IVC Laryngeal Cancer (Stage IV Laryngeal Cancer AJCC v7)", + "output": "something described as stage IVC includes: Any T, Any N, M1. M1: Distant metastasis." + }, + { + "input": "Concept: A. fumigatus IgE AB RAST Score (Immunoglobulin E measurement)", + "output": "Immunoglobulin E measurement described as a classification of the amount of Aspergillus fumigatus antigen IgE antibody present in a sample using the radioallergosorbent test (RAST) scoring system." + }, + { + "input": "Concept: origin recognition complex, subunit 2-like (yeast) protein, human (Biologically Active Substance)", + "output": "something described as origin recognition complex subunit 2 (577 aa, ~66 kDa) is encoded by the human ORC2 gene. This protein is involved in DNA replication initiation." + }, + { + "input": "Concept: lipoid dermatoarthritis (Disorder of lipid storage and metabolism)", + "output": "Disorder of lipoprotein AND/OR lipid metabolism described as a systemic disease, often associated with arthritis, fever, and weight loss. The cutaneous lesions consist of histiocytes, which are usually confined to the dermis. A large number of patients develop malignant tumors (carcinomas, sarcomas, and lymphomas). --2003" + }, + { + "input": "Concept: Cranberry Flavor (Structured Product Labeling Flavor)", + "output": "something described as a characteristic of a medicinal product, specifying that its most predominant agreeable savor detected by the unified sensation of taste and olfactory receptors resembles cranberry." + }, + { + "input": "Concept: computer (technology/technique)", + "output": "manufactured apparatus described as a machine for performing calculations automatically." + }, + { + "input": "Concept: UHDR175 (Intellectual Product)", + "output": "Intellectual Product described as unified Huntington's Disease Rating Scale 1999 Version (UHDRS 1999 Version) Was the Functional Capacity information obtained from." + }, + { + "input": "Concept: tyrosine catabolism (Tyrosine Metabolism Pathway)", + "output": "alpha-amino acid catabolic process described as the chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." + }, + { + "input": "Concept: 1+ (CDC Mycobacterium Quantitation Scheme)", + "output": "something described as a finding of 1-9 bacilli per 10 250x fields." + }, + { + "input": "Concept: Iron accumulation in globus pallidus (Abnormal globus pallidus morphology)", + "output": "something described as an abnormal build up of iron (Fe) in the globus pallidus." + }, + { + "input": "Concept: WHODAS 2.0 36-item Version Interviewer-administered - Getting Household Work Done Needed (Intellectual Product)", + "output": "WHODAS 2.0 36-item Version Interviewer-administered Questionnaire Question described as world Health Organization Disability Assessment Schedule 2.0 36-item Version Interviewer-administered (WHODAS 2.0 36-item Version Interviewer-administered) Because of your health condition, in the past 30 days, how much difficulty did you have in: Getting all the household work done that you needed to do?" + }, + { + "input": "Concept: Condensers, Dental, Endodontic Filling Material (Device associated with dental materials)", + "output": "Dental equipment and devices described as dental condensers designed to pack filling materials into prepared root canals. Dental endodontic condensers are available to condense root-canal fillings vertically into prepared root canals (i.e., vertical condensers or pluggers) or to condense root-canal fillings horizontally against the wall of prepared root canals." + }, + { + "input": "Concept: NPL (Geographic Area)", + "output": "Country described as a country in southern Asia, between China and India, west of Bhutan." + }, + { + "input": "Concept: Talc (Pharmacologic Substance)", + "output": "Dusting powders described as a mineral, usually used in a powdered form. In cancer treatment, sterile talc powder is used to prevent pleural effusions (an abnormal collection of fluid in the space between the lungs and the chest wall). Sterile talc powder is inserted into the space, causing it to close up, so fluid cannot collect there." + }, + { + "input": "Concept: Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8 (Lugano Classification Hodgkin Lymphoma by AJCC v8 Stage)", + "output": "Neoplastic Process described as limited stage Hodgkin lymphoma based on the Lugano classification criteria. It includes stages I, IE, II, and IIE." + }, + { + "input": "Concept: AUMC % Extrapolation Pred (Area Under First Moment Curve)", + "output": "Area Under First Moment Curve described as the area under the moment curve (AUMC) from the last predicted non-zero concentration value to infinity as a percentage of the area under the moment curve extrapolated to infinity." + }, + { + "input": "Concept: Neoplasms, Fibrous Tissue (Neoplasm by histology)", + "output": "Neoplastic Process described as any neoplasm composed of fibrous tissue." + }, + { + "input": "Concept: Adventitious Disorders (Disease or Syndrome)", + "output": "Physical & Psychosomatic Disorders described as disabilities that are accidental or acquired, rather than congenital." + }, + { + "input": "Concept: inhibition of orcinol synthesis (regulation of orcinol biosynthetic process)", + "output": "negative regulation of secondary metabolite biosynthetic process described as any process that stops, prevents or reduces the frequency, rate or extent of orcinol biosynthetic process." + }, + { + "input": "Concept: Cd - Condylion (Body Location or Region)", + "output": "Anatomical point described as an anatomic point; the extreme superior point of the condyle." + }, + { + "input": "Concept: pallidothalamic tract (Body Part, Organ, or Organ Component)", + "output": "Body Part, Organ, or Organ Component described as a fiber pathway connecting the globus pallidus with the thalamus. It is not readily distinguished in myelin-stained cross-sections ( Carpenter-1983 )." + }, + { + "input": "Concept: N1mi (Finding)", + "output": "something described as a regional lymph node TNM finding indicating the presence of micrometastases (greater than 0.2 mm and/or more than 200 cells, but none greater than 2.0 mm)." + }, + { + "input": "Concept: SF-36 v2.0 Standard - Question 11b (SF36 v2 0 Standard Questionnaire Question)", + "output": "SF36 v2 0 Standard Questionnaire Question described as the Short Form 36 Health Survey Standard, US Version 2.0 (SF36 v2.0 Standard) Question 11b." + }, + { + "input": "Concept: POR (Oxidoreductase)", + "output": "Enzyme described as NADPH-cytochrome P450 reductase (677 aa, ~77 kDa) is encoded by the human POR gene. This protein plays a role in electron transfer." + }, + { + "input": "Concept: interleukin-9 synthesis (organonitrogen compound biosynthetic process)", + "output": "Molecular Function described as the chemical reactions and pathways resulting in the formation of interleukin-9." + }, + { + "input": "Concept: Insemination Catheters (Intrauterine catheter)", + "output": "something described as intrauterine catheters designed for the injection of washed sperm and/or fluid containing embryos into the uterine cavity. These catheters consist of a thin (e.g., 5 Fr), flexible, or semirigid tube (typically 18 to 30 cm long) that fit the curvature of the uterus while minimizing trauma to the cervix, endometrium, and uterine walls. Some of these catheters come with marls to allow the physician to predetermine the depth of placement of the sperm. They are used in the treatment of infertility (e.g., male or cervical factor infertility)." + }, + { + "input": "Concept: Inner third of dentin (Dentin)", + "output": "something described as the area in dentin between the inner one third the distance to the pulp and the pulp." + }, + { + "input": "Concept: Grade 3 Disseminated Intravascular Coagulation, CTCAE (Disseminated Intravascular Coagulation, CTCAE)", + "output": "Disseminated Intravascular Coagulation, CTCAE described as laboratory findings and bleeding" + }, + { + "input": "Concept: Measurement Unit Description (Data Element)", + "output": "something described as an expression that conveys significant information about the type of measurement of observation." + }, + { + "input": "Concept: NPI1J06 (NPI Questionnaire Question)", + "output": "NPI Questionnaire Question described as neuropsychiatric Inventory - Does the patient fidget excessively, seem unable to sit still, or bounce his/her feet or tap his/her fingers a lot?" + }, + { + "input": "Concept: microtubule polymerization based movement (Cell Function)", + "output": "Cell Function described as the movement of a cellular component as a result of microtubule polymerization." + }, + { + "input": "Concept: Pituitary Gland Paraganglioma (Pituitary Neoplasms)", + "output": "Neoplastic Process described as an extremely rare paraganglioma arising from chief cells of the dispersed paraganglia of the sellar region." + }, + { + "input": "Concept: Global developmental delay, severe (Finding)", + "output": "something described as a severe delay in the achievement of motor or mental milestones in the domains of development of a child." + }, + { + "input": "Concept: 9,11,13-Octadecatrienoic acid, (9Z,11E,13Z)- (linolenic acid)", + "output": "something described as a polyunsaturated long-chain fatty acid with an 18-carbon backbone and exactly three double bonds, originating from the 5th, 7th and 9th positions from the methyl end, with these three bonds in the cis-, trans- and cis- configurations, respectively." + }, + { + "input": "Concept: reiki (Physical Comfort Promotion)", + "output": "something described as a biofield therapy that relies upon a belief in an invisible energy that may be transmitted from healer to patient through intention." + }, + { + "input": "Concept: delta-cuprenene synthase activity (carbon-oxygen lyase activity, acting on phosphates)", + "output": "Molecular Function described as catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> delta-cuprenene + diphosphoric acid." + }, + { + "input": "Concept: 2p25.1 (Chromosome band)", + "output": "something described as part of the chromosome bands present on the short (p) arm of chromosome 2." + }, + { + "input": "Concept: Mitral prolapse (Structural disorder of heart)", + "output": "Blood, Heart and Circulation described as one or both of the leaflets (cusps) of the mitral valve bulges back into the left atrium upon contraction of the left ventricle." + }, + { + "input": "Concept: Protein Info (UML Entity)", + "output": "UML Entity described as protein; provides access to the encoding gene via its GenBank Accession, the taxon in which this instance of the protein occurs, and references to homologous proteins in other species." + }, + { + "input": "Concept: CPNIGMAB (Laboratory Procedure)", + "output": "Laboratory Procedure described as the determination of the amount of Chlamydia pneumoniae IgM antibody present in a sample." + }, + { + "input": "Concept: Grade 3 Hypoglycemia, CTCAE (Hypoglycemia, CTCAE)", + "output": "Hypoglycemia, CTCAE described as <40-30 mg/dL; <2.2-1.7 mmol/L" + }, + { + "input": "Concept: LLFA (Forearm)", + "output": "HumanSubstanceAdministrationSite described as the distal half of the left upper limb between the elbow and the wrist." + }, + { + "input": "Concept: Laryngeal Premalignant Condition (Head and Neck Precancerous Condition)", + "output": "something described as a premalignant pathologic process that affects the epithelial cells of the laryngeal mucosa." + }, + { + "input": "Concept: Heterophile Antibody Measurement (Immunologic Tests)", + "output": "Agglutinin measurement described as the determination of the amount of heterophile antibodies present in a sample." + }, + { + "input": "Concept: tocotrienol-rich fraction (Dietary Supplements)", + "output": "something described as an orally available nutritional supplement containing high amounts of the vitamin E family member tocotrienol with antioxidant, hypolipidemic and potential immunomodulating and antiproliferative activity. Upon oral administration, tocotrienol-rich fraction (TRF) accumulates in tumor cells and induces cell cycle arrest, programmed cell death, and inhibits tumor cell proliferation. In addition, this agent suppresses 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase activity and inhibits angiogenesis. Rice bran oil, palm oil and annatto seed oil are common sources of TRF." + }, + { + "input": "Concept: eIF2 Regulation Pathway (Molecular Function)", + "output": "Regulatory Pathway described as protein phosphorylation plays an important role in the control of translation by eukaryotic initiation factor-2 (eIF-2). eIF-2 binds GTP and Met-tRNAi and transfers the Met-tRNA to the 40S subunit, to form the 43S preinitiation complex. Later in the cycle, prior to elongation, the bound GTP is hydrolyzed, releasing eIF-2-GDP. For eIF-2 to promote another round of initiation, GDP must be exchanged for GTP, a reaction catalyzed by eIF-2B. Kinases activated by viral infection (PKR), endoplasmic reticulum stress (PERK/PEK), amino acid deprivation (GCN2), and hemin deficiency (HRI) can phosphorylate the a subunit of eIF-2. This phosphorylation stabilizes the eIF-2-GDP-eIF-2B complex, inhibiting the turnover of eIF-2B. eIF-2B is also inhibited by GSK-3b phosphorylation. These events result in a shut-down of cellular protein synthesis and can lead to apoptosis." + }, + { + "input": "Concept: Fetal extension (Sign or Symptom)", + "output": "station of fetus described as a change in the position of the head of the fetus as it descends through the maternal pelvic cavity during labor and delivery." + }, + { + "input": "Concept: Corti Organ (Cochlear duct)", + "output": "Labyrinth described as the principal sensory structure of the auditory system, which is located on the basilar membrane in the cochlea." + }, + { + "input": "Concept: negative regulation of dauer entry (Organism Function)", + "output": "something described as any process that stops, prevents or reduces the frequency, rate or extent of dauer entry." + }, + { + "input": "Concept: Physiologic Measurement Software (Intellectual Product)", + "output": "Intellectual Product described as software designed to operate physiologic measuring instruments, control/monitor a limited number of their functions, and/or process data obtained while measuring. This software is intended to work only with one or a few models of physiologic measuring instruments, usually from the same manufacturer. The software may perform a variety of algorithms to facilitate the operation and analysis of the measurements. Physiologic measuring software is not usually available separate from the tester but may be updated (i.e., through the release of modified versions) during the life of the measuring instrument. Dedicated physiologic measuring software intended for a great variety of measurements (e.g., cardiac output, spirometry, blood pressure) is available." + }, + { + "input": "Concept: Increased bone density of end part of the innermost ring finger bone (Abnormality of the epiphysis of the proximal phalanx of the 4th finger)", + "output": "Ivory epiphyses of the proximal phalanges of the hand described as sclerosis of the epiphysis of the proximal phalanx of the ring finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." + }, + { + "input": "Concept: transmembrane transporter activity (transporter activity)", + "output": "transporter activity described as enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." + }, + { + "input": "Concept: Device for Dressing Usually Used (Clinical or Research Assessment Answer)", + "output": "something described as a response indicating that an individual usually uses an aid or device for dressing, such as a button hook or zipper pull." + }, + { + "input": "Concept: Jeavons syndrome (Epilepsy, Reflex)", + "output": "Disease or Syndrome described as jeavons syndrome is an idiopathic generalized form of reflex epilepsy characterized by childhood onset, unique seizure manifestations, striking light sensitivity, and possible occurrence of generalized tonic-clonic seizures. Onset occurs in childhood, with a peak at 6-8 years of age. Eyelid myoclonia is the principle clinical feature and may or may not be associated with brief (less than 6) absences. The etiology is unknown but Jeavons syndrome appears to be genetically determined." + }, + { + "input": "Concept: SAINT KITTS AND NEVIS (Geographic Area)", + "output": "Country described as an independent federation of the Leeward Islands in the West Indies, consisting of Saint Christopher, Nevis, and Sombrero. Its capital is Basseterre. It was discovered by Columbus in 1493, settled by the British in 1625, the first of the Leeward Islands to be colonized by them. It was held jointly by the French and English 1628-1713, but returned to Great Britain by the Treaty of Utrecht in 1713. It was held by the French 1782-83. Under the British for the next 200 years, it gained its independence in 1983." + }, + { + "input": "Concept: Thrombolysis in Myocardial Infarction Flow-3 (Thrombolysis in Myocardial Infarction Flow)", + "output": "Finding described as complete perfusion. Antegrade flow into the bed distal to the obstruction occurs as promptly as into the bed from the involved bed and is as rapid as clearance from an uninvolved bed in the same vessel or the opposite artery. (Chesebro JH, Knatterud GL, Roberts R, et al, Thrombolysis in Myocardial Infarction (TIMI) Trial, Phase I: a comparison between intravenous tissue plasminogen activator and intravenous streptokinase: Clinical findings through hospital discharge, Circulation 76, No. 1, 142-154, 1987)" + }, + { + "input": "Concept: C3DR (Gene or Genome)", + "output": "something described as human CR2 wild-type allele is located in the vicinity of 1q32 and is approximately 36 kb in length. This allele, which encodes complement receptor type 2 protein, is involved in the activation of both B-cells and complement-mediated immunity. Mutation of the gene is associated with systemic lupus erythematosus type 9." + }, + { + "input": "Concept: Peptide YY Measurement (Protein or Enzyme Type Measurement)", + "output": "something described as the determination of the amount of peptide YY present in a sample." + }, + { + "input": "Concept: cuticle pattern formation (regionalization)", + "output": "regionalization described as the regionalization process that gives rise to the patterns of cell differentiation in the cuticle." + }, + { + "input": "Concept: Long Course Chemoradiotherapy (Chemoradiotherapy)", + "output": "Chemoradiotherapy described as chemoradiotherapy generally consisting of 45 Gy given in 25 fractions over 5 weeks with concomitant chemotherapy as a radiosensitizer." + }, + { + "input": "Concept: SF36 v1.0 Standard - Question 3i (Intellectual Product)", + "output": "SF36 v1.0 Standard Questionnaire Question described as the Short Form 36 (SF-36) Health Survey Standard, US Version 1.0 (SF36 v1.0 Standard) Question 3i." + }, + { + "input": "Concept: irPD (Intellectual Product)", + "output": "Intellectual Product described as a minimum 20% increase and minimum 5 mm absolute increase in total measured tumor burden compared to nadir, or irPD for non-target or new non-measurable lesions. Confirmation of progression is recommended minimum 4 weeks after the first irPD assessment." + }, + { + "input": "Concept: ANTIBODY DEFICIENCY AND IMMUNE DYSREGULATION, PLCG2-ASSOCIATED (Disease or Syndrome)", + "output": "Familial cold urticaria described as a rare hereditary immune deficiency with skin involvement characterised by early-onset cold urticaria after generalised exposure to cold air or evaporative cooling and not after contact with cold objects. Additional immunologic abnormalities are often present - antibody deficiency, recurrent infections, autoimmune disease and symptomatic allergic disease. Caused by heterozygous deletion within the PLCG2 gene on chromosome 16q23." + }, + { + "input": "Concept: lupus erythematosus neonatal (Congenital connective tissue disorder)", + "output": "Newborn complications NEC described as a self-limited skin rash that appears in the neonatal period and usually resolves in four to six months after birth. It is caused by placental transfer of maternal autoantibodies, usually anti-Ro antibody. In a minority of cases, it is associated with congenital heart block, hepatitis, or thrombocytopenia. The mothers of the affected babies may be asymptomatic or suffer from systemic lupus erythematosus, Sjogren's syndrome, or rheumatoid arthritis." + }, + { + "input": "Concept: plastoglobule (cellular anatomical entity)", + "output": "cellular anatomical entity described as a lipoprotein particle present in chloroplasts. They are rich in non-polar lipids (triglycerides, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids." + }, + { + "input": "Concept: distal arthrogryposis-mental retardation-characteristic facies syndrome (Disease or Syndrome)", + "output": "something described as a potentially lethal syndrome of multiple congenital contractures, mental retardation, and facial anomalies." + }, + { + "input": "Concept: Nematospiroides dubius (Eukaryote)", + "output": "Heligmosomoides described as a species of intestinal nematode parasites which occur most commonly in mice. Infection is by ingesting larvae. This particular species is used extensively in immunological research." + }, + { + "input": "Concept: Energy Conservation (Health Care Activity)", + "output": "Energy Maintenance described as regulating energy use to treat or prevent fatigue and optimize function" + }, + { + "input": "Concept: Agoraphobia, NOS (Fear symptoms and phobic disorders)", + "output": "Mental or Behavioral Dysfunction described as obsessive, persistent, intense fear of open places." + }, + { + "input": "Concept: Fox Chase SCID Mouse (Mammal)", + "output": "Mammal described as discovered by Bosma (1980) at Fox Chase Cancer Center, the CB17 SCID mouse has an autosomal recessive mutation in the Prkdc gene which causes a severe combined immunodeficiency affecting B and T lymphocytes." + }, + { + "input": "Concept: BCR/ABL1 Fusion Protein with ABL1 NP 005148.2:p.Val299Leu (Fusion Proteins, bcr-abl)", + "output": "Fusion Proteins, bcr-abl described as a fusion protein encoded by the BCR/ABL1 fusion gene with ABL1 NM_005157.4:c.895G>C or c.895G>T mutation. This protein is comprised of the N-terminus of the breakpoint cluster region protein fused to almost the entire tyrosine-protein kinase ABL1 protein where the valine at position 299 of the ABL1 protein has been replaced by leucine." + }, + { + "input": "Concept: Global Alignment of Immunization safety Assessment in pregnancy Level 2 Placenta Previa (GAIA Antenatal Bleeding Level of Diagnostic Certainty)", + "output": "something described as level 2 Placenta Previa is defined by three criteria: first, painless vaginal bleeding during the second or third trimester; second, a high presenting part or abnormal fetal lie; third, pelvic exam with fullness palpable in the fornices (avoiding digital cervical exam) OR a speculum exam with placental tissue visible through an open cervical os." + }, + { + "input": "Concept: sphingomyelin carrier activity (sphingolipid transfer activity)", + "output": "sphingolipid transfer activity described as removes a sphingomyelin from the outer leaflet of a donor membrane, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to the outer leaflet of an acceptor membrane." + }, + { + "input": "Concept: complement component c1 (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as the first complement component to act in the activation of CLASSICAL COMPLEMENT PATHWAY. It is a calcium-dependent trimolecular complex made up of three subcomponents: COMPLEMENT C1Q; COMPLEMENT C1R; and COMPLEMENT C1S at 1:2:2 ratios. When the intact C1 binds to at least two antibodies (involving C1q), C1r and C1s are sequentially activated, leading to subsequent steps in the cascade of COMPLEMENT ACTIVATION." + }, + { + "input": "Concept: Premalignant State (Neoplasms)", + "output": "cancer-related problem/condition described as a pathological process with signs indicating it may become cancerous. Representative examples include leukoplakia, dysplastic nevus, actinic keratosis, xeroderma pigmentosum, and intraepithelial neoplasia. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C3341\" active clinical trials using this agent." + }, + { + "input": "Concept: regulation of positive chemotaxis to cAMP by DIF-1 (Cell Function)", + "output": "something described as any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-1. DIF-1 is a chlorinated alkylphenone." + }, + { + "input": "Concept: Ichthyosis, X-Linked (Steroid Sulfatase Deficiency Disease)", + "output": "Ectodermal Dysplasia described as the second most common form of ichthyosis. It is an X-linked inherited disorder with mild skin manifestations. The skin changes appear at birth and include keratinization and scaling." + }, + { + "input": "Concept: Chelating agent (Disposition)", + "output": "something described as a substance that forms a complex with metal ions or other substrates" + }, + { + "input": "Concept: Performed Procedure Step SOP Class UID (Identifier)", + "output": "Identifier described as the unique identifier for a performed procedure step class." + }, + { + "input": "Concept: cellular response to leukotriene B4 (cellular response to fatty acid)", + "output": "response to leukotriene B4 described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukotriene B4 stimulus." + }, + { + "input": "Concept: cyclotrons (SPECIFIC OCCUPATIONAL EQUIPMENT AND HAZARDS)", + "output": "Particle Accelerators described as equipment designed to accelerate particles (typically protons or deuterons) to high energies by combining a strong magnetic field and an oscillating electric field. The path formed is a spiral or a circle. The accelerated particles at the output may be used as a radiotherapy treatment beam on the patient, either directly or after passing a suitable target, but cyclotrons are used more frequently for in situ production of short-term positron-emitting radiopharmaceuticals (radionuclides) used in positron-emission tomography (PET) systems." + }, + { + "input": "Concept: GRF2 (Guanine Nucleotide Exchange Factors)", + "output": "something described as rap guanine nucleotide exchange factor 1 (1077 aa, ~121 kDa) is encoded by the human RAPGEF1 gene. This protein is involved in guanine nucleotide exchange activity." + }, + { + "input": "Concept: 11: 69922292-69960338 (Spatial Concept)", + "output": "Chromosome 11 Physical Location described as physical location of EMS1_Gene" + }, + { + "input": "Concept: It was easier than I expected (Clinical or Research Assessment Answer)", + "output": "Clinical or Research Assessment Answer described as a subjective response indicating that something was easier than expected." + }, + { + "input": "Concept: Dichotic Stimulation (Acoustic Stimulation)", + "output": "Acoustic Stimulation described as simultaneous presentation of different sounds to the two ears." + }, + { + "input": "Concept: CSS0311A (Intellectual Product)", + "output": "C-SSRS Baseline/Screening Version Phase 1 Study Version 1/14/09 Questionnaire Question described as columbia-Suicide Severity Rating Scale Baseline/Screening Version Phase 1 Study - What sort of reasons did you have for thinking about wanting to die or killing yourself? Was it to end the pain or stop the way you were feeling (in other words you couldn't go on living with this pain or how you were feeling) or was it to get attention, revenge or a reaction from others? Or both? (Lifetime)." + }, + { + "input": "Concept: Anterior semicircular canal (Body Space or Junction)", + "output": "Anterior semicircular duct described as one of the three semicircular canals found in the osseous labyrinth of the inner ear, which detects rotation of the head around a rostral-caudal (anterior-posterior) axis." + }, + { + "input": "Concept: Retinal vasc. occlusion (Disorders of choroid and retina)", + "output": "Disorders of choroid and retina described as an occlusion of the retinal vasculature." + }, + { + "input": "Concept: Vaginal Cancer cM0 TNM Finding v7 (Vaginal Cancer Clinical Distant Metastasis TNM Finding v7)", + "output": "Vaginal Cancer Clinical Distant Metastasis TNM Finding v7 described as vaginal cancer without evidence of distant metastasis." + }, + { + "input": "Concept: yttrium Y 90-labeled basiliximab (ANTINEOPLASTIC RADIOPHARMACEUTICALS)", + "output": "ANTINEOPLASTIC RADIOPHARMACEUTICALS described as a radioimmunoconjugate composed of basiliximab, a chimeric, mouse-human monoclonal antibody directed against the alpha subunit of interleukin-2 receptor (IL-2R alpha, CD25 or Tac antigen), and labeled with yttrium y 90, with potential antineoplastic activity. The basiliximab moiety of yttrium Y 90 basiliximab selectively binds to IL-2R alpha expressed on the surface of activated T-lymphocytes, thereby preventing IL-2 binding and blocking the IL-2-mediated activation of lymphocytes. The yttrium y 90 moiety selectively delivers a cytotoxic dose of beta radiation to lymphocytes that express the IL-2 receptor. This may prevent T cell-mediated activation of the immune system against a certain transplant and may prevent transplant rejection. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C99167\" active clinical trials using this agent." + }, + { + "input": "Concept: high-affinity basic amino acid transmembrane transporter activity (basic amino acid transmembrane transporter activity)", + "output": "basic amino acid transmembrane transporter activity described as enables the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." + }, + { + "input": "Concept: down-regulation of metalloendoproteinase activity involved in amyloid precursor protein catabolic process (negative regulation of amyloid precursor protein catabolic process)", + "output": "negative regulation of amyloid precursor protein catabolic process described as any process that stops, prevents or reduces the frequency, rate or extent of metalloendopeptidase activity involved in amyloid precursor protein catabolic process." + }, + { + "input": "Concept: INFECT ASTROVIRIDAE (RNA Virus Infections)", + "output": "RNA Virus Infections described as infections with ASTROVIRIDAE, causing gastroenteritis in human infants, calves, lambs, and piglets." + }, + { + "input": "Concept: DIP4 of the Foot (Body Part, Organ, or Organ Component)", + "output": "Body Part, Organ, or Organ Component described as a ginglymoid (hinge) synovial joint within the fourth digit of the foot articulating the middle and distal phalanges." + }, + { + "input": "Concept: fovea centralis retinae (Neuroanatomy)", + "output": "EYES AND EYE APPENDAGES described as area within the macula lutea where the retina thins out greatly because of the oblique shifting of all layers except the pigment epithelium layer; includes the sloping walls of the fovea (clivus) and contains a few rods in its periphery; in its center (foveola) are the cones most adapted to yield high visual acuity, each cone being connected to only one ganglion cell." + }, + { + "input": "Concept: HYDROPHOBIA (Phobic anxiety disorder)", + "output": "Phobic anxiety disorder described as acute VIRAL CNS INFECTION affecting mammals, including humans. It is caused by RABIES VIRUS and usually spread by contamination with virus-laden saliva of bites inflicted by rabid animals. Important animal vectors include the dog, cat, bat, fox, raccoon, skunk, and wolf." + }, + { + "input": "Concept: EXACT - Night Sleep Disturbed (EXACT Questionnaire Question)", + "output": "Intellectual Product described as exacerbations of Chronic Pulmonary Disease Tool Patient-Reported Outcome - Last night, was your sleep disturbed?" + }, + { + "input": "Concept: Intake of quick service food (Quantitative Concept)", + "output": "something described as intake of fast foods." + }, + { + "input": "Concept: Brodmann's area 15 (Body Location or Region)", + "output": "Body Location or Region described as a subdivision of the cerebral cortex of the guenon defined on the basis of cytoarchitecture. It is located in the part of the insula nearest the limen insula. The cortex is somewhat thinner with less cellular density than in other parts of the insula. The molecular layer of the cerebral cortex (I) is unusually wide; the external granular layer (II) and the external pyramidal layer (III) are less dense, and the internal granular layer (IV) is totally absent, so that the medium-sized pyramidal cells of layer III and the internal pyramidal layer (V) merge with a few isolated granular cells scattered at their boundary. The multiform layer (VI) divides into a more densely cellular outer sublayer (VIa) and a less dense inner sublayer (VIb). As in area 14 of Brodmann (guenon), the sublayer VIb merges with the adjacent claustrum. The cells in all of layer VI form tangential rows similar to the formation seen in area 10 of Brodmann (guenon) and area 11 of Brodmann (guenon) ( Brodmann-1905 ).\\r\\nArea 15 of Brodmann is topologically equivalent to the agranular insula of the macaque. It and area 16 of Brodmann (guenon) together are most nearly equivalent to the agranular insular area of later architectonic segmentations." + }, + { + "input": "Concept: gall bladder development (Organ or Tissue Function)", + "output": "something described as the progression of the gall bladder over time, from its initial formation to the mature structure. The gall bladder is a cavitated organ that stores bile." + }, + { + "input": "Concept: AGP7 (PRTN3 gene)", + "output": "Gene or Genome described as human PRTN3 wild-type allele is located in the vicinity of 19p13.3 and is approximately 7 kb in length. This allele, which encodes myeloblastin protein, plays a role in the induction of factor-independent growth of hematopoietic cells. Overexpression of the PRTN3 gene is associated with Wegener granulomatosis." + }, + { + "input": "Concept: boss receptor activity (transmembrane receptor protein tyrosine kinase activity)", + "output": "something described as combining with a protein bride of sevenless (boss) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." + }, + { + "input": "Concept: Provides foods of known protein content to meet the need of the individual in consistent amounts and/or consistent times. (Therapeutic or Preventive Procedure)", + "output": "something described as provides foods of known protein content to meet the need of the individual in consistent amounts and/or consistent times." + }, + { + "input": "Concept: G-protein activated inward rectifier potassium channel activity (Molecular Function)", + "output": "inward rectifier potassium channel activity described as enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force." + }, + { + "input": "Concept: alpha6-beta4 integrin-Fyn complex location (plasma membrane protein complex)", + "output": "something described as a protein complex that consists of an alpha6-beta4 integrin complex bound to the Src family tyrosine kinase Fyn." + }, + { + "input": "Concept: procaspase activating compound-1 VO-100 (Pharmacologic Substance)", + "output": "Organic Chemical described as an orally bioavailable procaspase activating compound-1 (PAC-1), with potential proapoptotic and antineoplastic activities. Upon administration, VO-100 binds to and forms a chelating complex with zinc (Zn) ions inside cells, which prevents the binding of Zn ions to procaspase-3 (PC3) and abrogates the Zn-mediated inhibition of PC3. This allows for the proteolytic autoactivation of PC3 into the active form caspase-3. This results in the selective caspase-3-mediated induction of apoptosis and cell death in cancer cells. In addition, VO-100 is able to cross the blood-brain-barrier (BBB). PC3, a Zn-inhibited proenzyme, is upregulated in a variety of cancer cell types, while its expression is minimal in normal healthy cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C120318\" active clinical trials using this agent." + }, + { + "input": "Concept: Experimental Organism Benign Mixed Mullerian Tumor (Experimental Organism Neoplasm)", + "output": "something described as a benign neoplasm of the female reproductive tract arising from pluripotent mesodermal cells of the Mullerian ducts." + }, + { + "input": "Concept: Infant Nutritional Physiology (Dietary Modification)", + "output": "Nutrition function described as nutritional studies with a focus on the specific nutritional needs of children under the age of 2." + }, + { + "input": "Concept: Transforming Growth Factor-Beta Family Gene (Growth Factor Gene)", + "output": "Gene or Genome described as expressed in a variety of tissues, Transforming Growth Factor-Beta Family Genes encode Transforming Growth Factor-Beta, an autocrine growth factor that can act synergistically with TGF-alpha in embryonic development, cellular differentiation, hormone secretion, and immune function. There are at least three forms of TGF-beta: TGF-beta 1, TGF-beta 2, and TGF-beta 1.2. The latter is a heterodimer of TGF-beta 1 and TGF-beta 2." + }, + { + "input": "Concept: Alanine, L-Isomer (alanine)", + "output": "Alpha amino acid described as a small non-essential amino acid in humans, Alanine is one of the most widely used for protein construction and is involved in the metabolism of tryptophan and vitamin pyridoxine. Alanine is an important source of energy for muscles and central nervous system, strengthens the immune system, helps in the metabolism of sugars and organic acids, and displays a cholesterol-reducing effect in animals." + }, + { + "input": "Concept: Sodium phenylbutyrate product (Sodium Compounds)", + "output": "Organic Chemical described as the sodium salt of phenylbutyrate, a derivative of the short-chain fatty acid butyrate, with potential antineoplastic activity. Phenylbutyrate reversibly inhibits class I and II histone deacetylases (HDACs), which may result in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1440\" active clinical trials using this agent." + }, + { + "input": "Concept: Non-Moribund Sacrifice (Sacrifice)", + "output": "Sacrifice described as an indication that a subject was euthanized due to factors not associated with the general health of the subject." + }, + { + "input": "Concept: Forceps Injury (Birth Injuries)", + "output": "Birth Injuries described as birth injury sustained during a forceps-assisted delivery." + }, + { + "input": "Concept: Unit per kilogram per hour (Unit of Dose Calculation)", + "output": "something described as an arbitrary unit of substance rate expressed in unit(s) per kilogram per period of time equal to sixty minutes." + }, + { + "input": "Concept: iNKT Cell (Natural Killer Cells)", + "output": "Cell described as a natural killer T-cell subtype bearing an invariant T-cell receptor. Invariant natural killer T-cells recognize a small variety of glycolipid antigens presented in the context of CD1d. These cells play a regulatory role during an immune response by producing cytokines." + }, + { + "input": "Concept: Southern Sami Language (Language)", + "output": "Sami Language described as a Uralic Sami language spoken mostly in Snasa, Royrvik, Roros, and Hattfjelldal in Norway." + }, + { + "input": "Concept: Major Salivary Gland Cancer Pathologic Primary Tumor TNM Finding v8 (Major Salivary Gland Cancer Pathologic TNM Finding v8)", + "output": "Major Salivary Gland Cancer Pathologic TNM Finding v8 described as a pathologic finding about one or more characteristics of major salivary gland cancer, following the rules of the TNM AJCC v8 classification system as they pertain to staging of the primary tumor." + }, + { + "input": "Concept: food technology (Food Industry)", + "output": "Food Industry described as the application of knowledge to the food industry." + }, + { + "input": "Concept: Stage IIIA Adenocarcinoma of the Lung (Neoplastic Process)", + "output": "Non-small cell lung cancer stage IIIA described as stage IIIA includes: (T1a, N2, M0); (T1b, N2, M0); (T2a, N2, M0); (T2b, N2, M0); (T3, N1, M0); (T3, N2, M0); (T4, N0, M0); (T4, N1, M0). T4: Lung cancer with a tumor of any size that invades any of the following: mediastinum, heart, great vessels, trachea, recurrent laryngeal nerve, esophagus, vertebral body, carina, and separate tumor nodule(s) in a different ipsilateral lobe. N1: Lung cancer with metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary lymph nodes, including involvement by direct extension. N2: Lung cancer with metastasis to ipsilateral mediastinal and/or subcarinal lymph nodes. M0: No distant metastasis." + }, + { + "input": "Concept: Perilipin 1 related familial partial lipodystrophy (Familial partial lipodystrophy)", + "output": "Insulin Resistance described as a rare genetic lipodystrophy with characteristics of loss of subcutaneous adipose tissue primarily affecting the lower limbs and gluteal region due to a defect in the PLIN1 gene. Associated features of insulin resistance, hepatic steatosis, dyslipidemia, hypertension, axillary acanthosis nigricans and muscular hypertrophy of the lower limbs are typical. Caused by heterozygous mutation in the PLIN1 gene on chromosome 15q26." + }, + { + "input": "Concept: cytoplasmic cyclin-dependent protein kinase holoenzyme complex location (cyclin-dependent protein kinase holoenzyme complex location)", + "output": "something described as cyclin-dependent protein kinase (CDK) complex found in the cytoplasm." + }, + { + "input": "Concept: GBC590 (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as a modified citrus pectin exhibiting antimetastatic activity. GBC-590 binds to and inhibits galectin-3 receptor, resulting in mitigation of the metastatic process." + }, + { + "input": "Concept: Soft Tissue Sarcoma of the Abdomen and Thoracic Visceral Organs pT1 TNM Finding v8 (Finding)", + "output": "something described as soft tissue sarcoma of the abdomen and thoracic visceral organs, organ confined." + }, + { + "input": "Concept: flavonol synthase activity (2-oxoglutarate-dependent dioxygenase activity)", + "output": "2-oxoglutarate-dependent dioxygenase activity described as catalysis of the reaction: a dihydroflavonol + 2-oxoglurate + O2 = a flavonol + succinate + CO2 + H2O." + }, + { + "input": "Concept: carcinoma of the glottis (Carcinoma of larynx)", + "output": "Carcinoma of larynx described as a carcinoma of the larynx that arises from the glottic area." + }, + { + "input": "Concept: Adrenal Cortical Carcinoma cM1 TNM Finding v8 (Adrenal Cortical Carcinoma Clinical Distant Metastasis TNM Finding v8)", + "output": "Finding described as distant metastasis." + }, + { + "input": "Concept: sodium/choline symporter activity (choline transmembrane transporter activity)", + "output": "choline transmembrane transporter activity described as enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in)." + }, + { + "input": "Concept: IDS-C - Pleasure or Enjoyment (IDS-C Clinical Classification Question)", + "output": "something described as inventory of Depressive Symptomatology - Clinician-Rated - Please circle one response to each item that best describes the patient for the last seven days: Pleasure/enjoyment (exclude sexual activities)." + }, + { + "input": "Concept: Curated (Molecular Biology Research Technique)", + "output": "Molecular Biology Research Technique described as the manual aggregation and curation of independently reported structural variants from several online resources. These often clinically important variants would not otherwise find their way into a public catalogue of important structural variation. Examples include variants sporadically reported in the scientific literature, or stored in clinically-oriented online resources (e.g., OMIM) or in locus-specific databases (LSDBs)." + }, + { + "input": "Concept: Hospital Legislation (Regulation or Law)", + "output": "Regulation or Law described as laws and regulations concerning hospitals, which are proposed for enactment or enacted by a legislative body." + }, + { + "input": "Concept: Bone, skeletal (Bony skeleton subdivision)", + "output": "Body organ structure described as hard form of connective tissue that constitutes the majority of the skeleton of most vertebrates; it consists of an organic component (the cells and matrix) and an inorganic, or mineral component; the matrix contains a framework of collagenous fibers and is impregnated with the mineral component, chiefly calcium phosphate and calcium carbonate, which imparts the quality of rigidity to bone." + }, + { + "input": "Concept: Multicystic Renal Dysplasias (Renal cyst)", + "output": "Kidney described as a congenital anomaly of the kidney and urinary tract in which one or both kidneys are large, distended by multiple cysts, and non-functional. Global prevalence is not known, but the unilateral form is the most frequent. The disorder frequently presents antenatally at routine ultrasound scan. Bilateral disease is considered a lethal entity and most pregnancies are terminated. The disorder results from disrupted nephrogenesis but the exact pathogenic mechanism is still unknown. Mutations in the HNF1B gene (17q12) are strongly associated with the development of this disease. Most cases are sporadic." + }, + { + "input": "Concept: Bachelor of Fine Arts (Bachelor's Degree)", + "output": "Degree/license/certificate described as a bachelor's degree in arts awarded to students seeking a professional education in the visual or performing arts." + }, + { + "input": "Concept: Testosterone Level Finding (Finding)", + "output": "Laboratory test finding described as a finding that indicates the amount of testosterone in a sample." + }, + { + "input": "Concept: lateral root formation (Organism Function)", + "output": "post-embryonic development described as the process that gives rise to a lateral root. This process pertains to the initial formation of a structure from unspecified parts. A lateral root primordium represents an organized group of cells derived from the root pericycle that will differentiate into a new root, as opposed to the initiation of the main root from the embryo proper." + }, + { + "input": "Concept: Childhood Bullying Recovery (Psychosocial Adaptation)", + "output": "something described as personal actions to promote psychological recovery from adverse effects of childhood bullying" + }, + { + "input": "Concept: Estimated intake of plant fibre in 24 hours (Quantitative Concept)", + "output": "something described as approximate amount of plant fiber intake from all sources including food, beverages, breastmilk/formula, supplements, and via enteral and parenteral routes." + }, + { + "input": "Concept: 3-(.alpha.-Acetonylbenzyl)-4-hydroxycoumarin (Vitamin K antagonists)", + "output": "Hazardous or Poisonous Substance described as synthetic coumarin anticoagulant." + }, + { + "input": "Concept: Oropharyngeal (p16-Negative) Cancer cN0 TNM Finding v8 (Finding)", + "output": "Finding described as oropharyngeal (p16-negative) cancer with no metastasis to regional lymph nodes." + }, + { + "input": "Concept: homicide (Behavior Disorders)", + "output": "Social Problems described as killing of one person by another." + }, + { + "input": "Concept: Diaphragm (Biomedical or Dental Material)", + "output": "Solid Dose Form described as a device usually dome-shaped, worn during copulation over the cervical mouth for prevention of conception or infection." + }, + { + "input": "Concept: Grade 3 Fetal Growth Retardation, CTCAE (Finding)", + "output": "something described as <5% percentile of weight for gestational age" + }, + { + "input": "Concept: Localized Gastroesophageal Junction Adenocarcinoma (Neoplastic Process)", + "output": "Adenocarcinoma of the gastroesophageal junction described as an adenocarcinoma that arises from the gastroesophageal junction and has not spread to other anatomic sites." + }, + { + "input": "Concept: LPI (Finding)", + "output": "something described as a finding referring to the presence of a cellular infiltrate that is composed of lymphocytes and plasma cells in a tissue sample." + }, + { + "input": "Concept: Nevus melanotic (Benign neoplasm of skin)", + "output": "Hamartoma described as a oval and round, colored (usually medium-to dark brown, reddish brown, or flesh colored) lesion. Typically, a melanocytic nevus is less than 6 mm in diameter, but may be much smaller or larger." + }, + { + "input": "Concept: Pathologic Stage IIA Gastroesophageal Junction Adenocarcinoma AJCC v8 (Pathologic Stage II Gastroesophageal Junction Adenocarcinoma AJCC v8)", + "output": "Neoplastic Process described as stage IIA includes: (T2, N0, M0, G3); (T2, N0, M0, GX). T2: Tumor invades the muscularis propria. N0: No regional lymph node metastasis. M0: No distant metastasis. GX: Grade cannot be assessed. G3: Poorly differentiated, undifferentiated." + }, + { + "input": "Concept: EXHALED BREATH CONDENSATE (Exhaled air)", + "output": "Exhaled air described as expired air that has been condensed." + }, + { + "input": "Concept: Embryonal Carcinomas (Neoplasms)", + "output": "Neoplasms described as a non-seminomatous malignant germ cell tumor characterized by the presence of large germ cells with abundant cytoplasm resembling epithelial cells, geographic necrosis, high mitotic activity, and pseudoglandular and pseudopapillary structures formation. It can arise from the testis, ovary, and extragonadal sites (central nervous system and mediastinum)." + }, + { + "input": "Concept: medial division of the periaqueductal gray (Body Part, Organ, or Organ Component)", + "output": "something described as a subdivision of the periaqueductal gray as segmented in the functionally defined motor periaqueductal gray. It is a narrow band of cells that surrounds the cerebral aqueduct throughout its course. It represents the medial most portion of each of the four longitudinal columns of the classical periaqueductal gray. Functionally the motor periaqueductal gray belongs to the behavior control column of the cerebrospinal trunk ( Swanson-2004 ). For other components of the motor periaqueductal gray click below: Models Where It Appears > Functional CNS Model - Rat." + }, + { + "input": "Concept: MAGE3 (Gene or Genome)", + "output": "Gene or Genome described as this gene may be involved in embryonal development. It may also play a role in carcinogenesis." + }, + { + "input": "Concept: Trapezoidcephaly-multiple synostosis (Disease or Syndrome)", + "output": "Disease or Syndrome described as antley-Bixler Syndrome phenotype with normal genitalia and normal steroidogenesis, and associated with autosomal dominant mutations in FGFR2, the gene for FIBROBLAST GROWTH FACTOR RECEPTOR 2." + }, + { + "input": "Concept: Over-ride (HL7 Vocabulary Version 2.5)", + "output": "HL7 Vocabulary Version 2.5 described as to take precedence over and countermand, thereby allowing an activity to continue despite a warning or error." + }, + { + "input": "Concept: glyceride metabolism (Molecular Function)", + "output": "something described as the chemical reactions and pathways involving acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." + }, + { + "input": "Concept: Nephrotic Syndrome with Lesion of Focal Glomerulosclerosis (Nephrotic Syndrome)", + "output": "Disease or Syndrome described as a renal functional disorder characterized by proteinuria, edema, hyperlipidemia and hypoalbuminemia. It results from damage to the renal vascular filtration apparatus. It is further characterized by scarring of some of the glomerular capillaries. Sequelae may include hypertension, atherosclerosis, infection, hypercoagulablity and renal failure." + }, + { + "input": "Concept: Joubert Syndrome Gene Mutation Reagents (IVD Panels, Human Genetics, Encephalopathy, Brain Malformation, Joubert Syndrome)", + "output": "IVD Panels, Human Genetics, Encephalopathy, Brain Malformation, Joubert Syndrome described as molecular assay reagents intended to identify mutations in genes associated with Joubert syndrome, a collection of brain malformations affecting the brainstem and the cerebellar vermis. Genetic variants at multiple loci have been associated with Joubert syndrome. These reagents are intended to detect mutations in multiple Joubert syndrome-associated loci simultaneously." + }, + { + "input": "Concept: Sugar acid (Carboxylic Acids)", + "output": "Hydroxy Acids described as MONOSACCHARIDES and other sugars that contain one or more carboxylic acid moieties." + }, + { + "input": "Concept: tandutinib (Protein-tyrosine kinase inhibitor)", + "output": "something described as a piperazinyl quinazoline receptor tyrosine kinase inhibitor with antineoplastic activity. Tandutinib inhibits the autophosphorylation of FLT3 (FMS-Like Tyrosine kinase-3), c-KIT and PDGF (platelet-derived growth factor) receptor tyrosine kinases, thereby inhibiting cellular proliferation and inducing apoptosis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C48404\" active clinical trials using this agent." + }, + { + "input": "Concept: Urethral Cancer Clinical TNM Finding v7 (Finding)", + "output": "Finding described as a clinical finding about one or more characteristics of urethral cancer, following the rules of the TNM AJCC v7 classification system." + }, + { + "input": "Concept: TSCC01-Wanting to Yell and Break Things (Intellectual Product)", + "output": "something described as trauma Symptom Checklist for Children (TSCC) Wanting to yell and break things." + }, + { + "input": "Concept: MGC3844 (PSMD11 gene)", + "output": "something described as human PSMD11 wild-type allele is located in the vicinity of 17q11.2 and is approximately 39 kb in length. This allele, which encodes 26S proteasome non-ATPase regulatory subunit 11 protein, is involved in proteasome assembly and activity." + }, + { + "input": "Concept: Northwest Axis (Electrocardiogram finding)", + "output": "Electrocardiogram finding described as an electrocardiographic finding of a frontal plane QRS axis from -90 to +180 degrees." + }, + { + "input": "Concept: longitudinal flagellum (Cell Component)", + "output": "something described as a motile cilium found in dinoflagellates. It trails the cell and acts as a steering rudder. It is often partially contained in a furrow called the sulcus, and emerges from a flagellar pore located in the sulcus." + }, + { + "input": "Concept: NCOHORT (Quantitative Concept)", + "output": "Numbers described as the number of groups or cohorts that are part of the study." + }, + { + "input": "Concept: cytoplasmic fibers of the nuclear pore complex location (Cell Component)", + "output": "Cell Component described as filamentous extensions on cytoplasmic face of the nuclear pore complex (NPC). In S. cerevisiae, Nup159p, Nup82p, and Nup42p contribute to the cytoplasmic filaments. In vertebrates, Nup358 is a major component." + }, + { + "input": "Concept: Type of Study Sponsor (Qualitative Concept)", + "output": "Qualitative Concept described as an attribute used to indicate whether the sponsor assumes an ultimate responsibility for the initiation, management and/or financing of a clinical study, or provides support for these activities." + }, + { + "input": "Concept: regulation of antigen processing and presentation of peptide antigen (regulation of antigen processing and presentation)", + "output": "Biologic Function described as any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen." + }, + { + "input": "Concept: Moghaniae / yi tiao gen (Oriental herbs and natural substances letter M)", + "output": "something described as yi tiao gen" + }, + { + "input": "Concept: Paracetamol + propoxyphene napsylate (propoxyphene napsylate)", + "output": "Organic Chemical described as a combination preparation of propoxyphene napsylate and acetaminophen, with analgesic and antipyretic activities. Propoxyphene napsylate is a mild narcotic analgesic that binds to mu-opioid receptors in the central nervous system (CNS), thereby mimicking the effect of endogenous opioids. Acetaminophen possesses analgesic and antipyretic effects by interfering with prostaglandin synthesis." + }, + { + "input": "Concept: discipline (Health Care Activity)", + "output": "Action described as activities designed to promote appropriate behavior, conduct, or action including time out, limits, and controls." + }, + { + "input": "Concept: Therapeutic iNKT Cells (Antineoplastic Immune Cell)", + "output": "Cell described as a preparation of cytotoxic T-lymphocytes (CTLs) that express natural killer (NK)-like features (nCTLs), with potential immunomodulating and antineoplastic activities. The nCTLs are derived from autologous lymphocytes that have been in vitro exposed to autologous alpha-type-1 polarized dendritic cells that are pulsed with specific autologous tumor-associated antigens (TAAs); the nCTLs are subsequently expanded in the presence of the cytokine human interleukin-2 (IL-2). The generated nCTLs are potent CTLs that produce high amounts of granzyme B and perforin, and interferon-gamma (IFNg) with high killer activity and tumor-homing potential. Upon infusion of the autologous nCTLs, these cells specifically recognize the TAAs on the tumor cells, then bind to and directly lyse tumor cells." + }, + { + "input": "Concept: NAD-Dependent Protein Deacetylase Sirtuin-7 (Amino Acid, Peptide, or Protein)", + "output": "something described as NAD-dependent protein deacetylase sirtuin-7 (400 aa, ~45 kDa) is encoded by the human SIRT7 gene. This protein plays a role in protein deacetylation." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, MYC (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)", + "output": "Medical Device described as molecular assay reagents intended to identify mutations in the v-myc myelocytomatosis viral oncogene homologue (MYC, also known as c-Myc) gene, located at chromosome 8q24, which encodes for a multifunctional, nuclear phosphoprotein that is involved in cell cycle progression, apoptosis, and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations at this locus have been identified in patients with hematopoietic tumors, leukemias, and lymphomas, including Burkitt's lymphoma." + }, + { + "input": "Concept: Partial duplication of the distal phalanx of the 3rd finger (Partial duplication of the distal phalanges of the hand)", + "output": "Duplication of the distal phalanx of the 3rd finger described as partial duplication of the distal phalanx of middle finger, seen on x-rays as a broad and/or bifid phalanx." + }, + { + "input": "Concept: How long did this last (Clinical or Research Assessment Question)", + "output": "Clinical or Research Assessment Question described as a question about how long not feeling like eating lasted." + }, + { + "input": "Concept: Ophthalmological Diagnostic Techniques (Diagnostic Procedure)", + "output": "something described as methods and procedures for the diagnosis of diseases of the eye or of vision disorders." + }, + { + "input": "Concept: Mental disorder NOS due to a general medical condition (Mental or Behavioral Dysfunction)", + "output": "something described as used for disorders characterized by the presence of mental symptoms judged to be the direct physiological consequence of a general medical condition. Use only for disorders described by this or more specific phraseology. This could include \"Catatonic Disorder due to a General Medical Condition,\" \"Dementia due to a General Medical Condition,\" etc. For a more specific disorder, also use a term for the symptom (e.g., CATATONIA, DEMENTIA). Compare COMORBIDITY." + }, + { + "input": "Concept: Assessment of diversional care need (Health Care Activity)", + "output": "Leisure needs assessment described as assessment to determine leisure or play needs. Supports the selection of appropriate leisure activity or play with the aim of stimulating a change in mental outlook from negative to positive. These activities are supported in order to encourage motivation to recover from illness. Diversional care can also be used as a means of supporting a patient to improve the use of motor skills." + }, + { + "input": "Concept: nicotine replacement therapies (Replacement therapy)", + "output": "Replacement therapy described as therapy to help control nicotine withdrawal symptoms during tobacco cessation" + }, + { + "input": "Concept: Decrease in monounsaturated fat content of the diet compared to the assessed baseline intake of monounsaturated fat for the individual. (Fat-Restricted Diet)", + "output": "Monounsaturated fat modified diet described as decrease in monounsaturated fat content of the diet compared to the assessed baseline intake of monounsaturated fat for the individual." + }, + { + "input": "Concept: Campylobacter coli (Campylobacter)", + "output": "something described as a species of gram-negative, rod-shaped bacteria isolated from the intestinal tract of swine, poultry, and man. It may be pathogenic." + }, + { + "input": "Concept: Callus formation (multicellular organismal process)", + "output": "Biologic Function described as the process by which a callus is formed at a wound site. A plant callus is a portion of plant tissue that consists of mass of undifferentiated plant cells. It consists primarily of parenchyma cells but possibly contains other cell types as the callus begins to differentiate." + }, + { + "input": "Concept: CD246 Gene Translocation Negative (ALK Gene Rearrangement Negative)", + "output": "something described as a genetic finding indicating that translocations involving the ALK gene have not been detected in a sample." + }, + { + "input": "Concept: cervix uterine (Region of uterine body)", + "output": "Body Part, Organ, or Organ Component described as neck portion of the uterus between the lower isthmus and the vagina forming the cervical canal." + }, + { + "input": "Concept: IPAQ Long Last 7 Days Self-Administered Format Version - Traveling Hours per Day (IPAQ Long Last 7 Days Self-Administered Format Version Questionnaire Question)", + "output": "something described as international Physical Activity Questionnaire (August 2002) Long Last 7 Days Self-Administered Format (IPAQ Long Last 7 Days Self-Administered Format Version) How much time did you usually spend on one of those days traveling in a train, bus, car, tram, or other kind of motor vehicle?: hours per day." + }, + { + "input": "Concept: PI01-Average Pain Intensity (Intellectual Product)", + "output": "PI Questionnaire Question described as pain Intensity - Average pain intensity for various time periods of evaluation." + }, + { + "input": "Concept: CRF Completion Guidelines (Intellectual Product)", + "output": "Guidelines described as assignment of variable names and attributes to the fields on the case report form (CRF) used in data management procedures." + }, + { + "input": "Concept: CONSTIPATION CHRONIC (gastrointestinal)", + "output": "Sign or Symptom described as constipation for longer than three months with fewer than 3 bowel movements per week, straining, lumpy or hard stools, and a sensation of anorectal obstruction or incomplete defecation." + }, + { + "input": "Concept: Motion Related Artifact (Finding)", + "output": "something described as an artifact resulting from movement of the object being imaged during the imaging sequence." + }, + { + "input": "Concept: NLRB1 (NAIP gene)", + "output": "NAIP gene described as human NAIP wild-type allele is located in the vicinity of 5q13.1 and is approximately 56 kb in length. This allele, which encodes baculoviral IAP repeat-containing protein 1, plays a role in p53-mediated apoptosis and growth suppression by apoptotic induction." + }, + { + "input": "Concept: Caecal inflammation (Abdominal Infection)", + "output": "Abdominal Infection described as inflammation of the cecum, usually accompanied by neutropenia." + }, + { + "input": "Concept: phenanthrene-9,10-epoxide hydrolase (9R,10R-forming) activity (phenanthrene-9,10-epoxide hydrolase activity)", + "output": "Molecular Function described as catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9R,10R-dihydrodiolphenanthrene." + }, + { + "input": "Concept: Record of Retained Body Fluids or Tissue Samples (Records)", + "output": "Records described as a document recording the location and identification of samples being held for possible future (re)testing. May include destruction records." + }, + { + "input": "Concept: Grade III Astrocytic Neoplasm of the Cerebral Hemisphere (Cerebral Astrocytoma)", + "output": "Anaplastic astrocytoma described as an anaplastic astrocytoma that arises from the cerebral hemispheres." + }, + { + "input": "Concept: Bacillus d (Bacterium)", + "output": "Bacterium described as a species of gram-positive, rod-shaped bacteria associated with DENTAL CARIES." + }, + { + "input": "Concept: Recurrent Ewing Sarcoma (Neoplastic Process)", + "output": "something described as ewing sarcoma which has recurred after treatment and/or remission. While initial complete responses are not uncommon, there is a fair chance of relapse as late as one to two decades after initial therapy." + }, + { + "input": "Concept: protein localization in nuclear envelope (protein localization to nucleus)", + "output": "something described as a process in which a protein is transported to, or maintained at, a location within a nuclear envelope." + }, + { + "input": "Concept: LIMS1 (Adaptor Signaling Protein Gene)", + "output": "Adaptor Signaling Protein Gene described as this gene is essential for cell shape, motility, and survival." + }, + { + "input": "Concept: RNA, Viral (Nucleocapsid)", + "output": "RNA described as ribonucleic acid that makes up the genetic material of viruses." + }, + { + "input": "Concept: TLPD (Short rib dysplasia)", + "output": "Autosomal dominant hereditary disorder described as a short-rib dysplasia with characteristics of thoracic dystrophy, laryngeal stenosis and a small pelvis. Less than 10 cases have been reported in the literature so far. Patients present with severe respiratory distress (requiring intubation) during the neonatal period. The rib shortening is less severe than in Jeune syndrome and the thorax is characteristically small, narrow and bell-shaped. The pelvis is reduced in all dimensions and the combination of the thorax anomalies and the small pelvis give the appearance of a protruding abdomen. Subglottic stenosis has also been described but it remains unclear whether this is a congenital anomaly or is secondary to long-term intubation. Transmission is autosomal dominant." + }, + { + "input": "Concept: fumiquinazoline F metabolic process (fumiquinazoline metabolic process)", + "output": "indole-containing compound metabolic process described as the chemical reactions and pathways involving fumiquinazoline F." + }, + { + "input": "Concept: PODCI Adolescent Parent-Reported Version - Button Buttons (PODCI Adolescent Parent-Reported Version Questionnaire Question)", + "output": "something described as pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported - During the last week, was it easy or hard for your child to: Button buttons?" + }, + { + "input": "Concept: Aryepiglottic fold (Structure of junctional region with oropharynx)", + "output": "hypopharynx described as a membranous fold extending between the arytenoid cartilage and the epiglottis." + }, + { + "input": "Concept: Cyclic(D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl-D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl) (Antibiotic)", + "output": "Antibiotic described as a cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and related to the enniatins. It is composed of 3 moles each of L-valine, D-alpha-hydroxyisovaleric acid, D-valine, and L-lactic acid linked alternately to form a 36-membered ring. (From Merck Index, 11th ed) Valinomycin is a potassium selective ionophore and is commonly used as a tool in biochemical studies." + }, + { + "input": "Concept: document (Intellectual Product)", + "output": "something described as an ordered presentation of XML elements, possibly including text and tabular analyses, description, and figures. Descriptors for HL7 documents include type, class, and element. NOTE: In HL7, a document can be either physical (referring to the paper) or logical (referring to the content) with the following characteristics: 1) Stewardship; 2) Potential for authentication; 3) Wholeness; 4) Human readability; 5) Persistence; 6) Global vs. local context." + }, + { + "input": "Concept: Paralemniscal Nucleus (Lateral lemniscus)", + "output": "Body Part, Organ, or Organ Component described as groups of cells located within or adjacent to the lateral lemniscus in the pontine tegmentum. In the human ( Carpenter-1983 ) and the macaque ( Amunts-2012 ) they include a dorsal nucleus of the lateral lemniscus and a ventral nucleus of the lateral lemniscus. Some authors identify also a frontal nucleus of the lateral lemniscus in the human; it is located more rostrally at the level of the red nucleus in the midbrain tegmentum ( Crosby-1962 ). \\r\\nIn the rat ( Swanson-2004 ) and the mouse ( Dong-2004 ) the structures include, between the dorsal and ventral nuclei, a narrow horizontal nucleus of the lateral lemniscus. Some authors subdivide the ventral nucleus of the rat ( Paxinos-2009b ) and the mouse ( Franklin-2008 ) into an intermediate nucleus of the lateral lemniscus and a ventral nucleus of the lateral lemniscus (Paxinos). Functionally the nuclei of the lateral lemniscus are part of the subcortical auditory system ( Swanson-2004 )." + }, + { + "input": "Concept: Data Entry Guideline (Intellectual Product)", + "output": "Intellectual Product described as documentation describing the proper entry of data from a paper case report form (CRF) to a database." + }, + { + "input": "Concept: cals (Thesaurus of Psychological Index Terms)", + "output": "Nutrition, Dietary Components described as role of caloric intake in cancer causation or prevention and in general health." + }, + { + "input": "Concept: home visit (Home care of patient)", + "output": "something described as visits to the patient's home by professional personnel for the purpose of diagnosis and/or treatment." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Immunoassay, Diabetes (IVD Test Reagent/Kits, Immunoassay)", + "output": "something described as immunoassay reagents intended to perform qualitative and/or quantitative analyses of a sample of body fluids (typically serum) to determine one or more of the group of hormones and other substances (e.g., C-peptide, glucogen) that modulate the regulation of glucose concentration in blood." + }, + { + "input": "Concept: Hooks, Surgical, Nasal, Polyp (Hooks, Surgical, Nasal)", + "output": "something described as nasal surgical hooks designed to temporarily secure nasal tissues by catching and/or pulling them during inspection of a nasal polyp with minimal trauma. These nasal surgical hooks typically consist of handheld manual stainless steel instruments with a shank shallow bent near the distal end (usually at angles from 135 to 180 degrees) and finished in a blunt or sharp tip; the hooks typically include a handle at the proximal end. Nasal polyp hooks usually draw the soft palate forward to allow inspection of the mass; they are provided with a proper smooth finish, durability and flexibility. Nasal polyp hooks are used during medical procedures (e.g., to examine the palate in search of evidence of polyps)." + }, + { + "input": "Concept: pyrimidine nucleotide-sugar transmembrane transporter activity (Molecular Function)", + "output": "something described as enables the transfer of a pyrimidine nucleotide-sugar from one side of a membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." + }, + { + "input": "Concept: Intermediate Blood Vessel Neoplasm (Blood Vessel Tumors)", + "output": "Blood Vessel Tumors described as a borderline blood vessel neoplasm that can be locally aggressive, and may metastasize on rare occasions." + }, + { + "input": "Concept: Ubiquitin B wt Allele (UBB gene)", + "output": "Gene or Genome described as human UBB wild-type allele is located within 17p12-p11.2 and is approximately 2 kb in length. This allele, which encodes ubiquitin protein, plays a role in protein turnover regulation. The allele is required for targeting proteins to the proteasome." + }, + { + "input": "Concept: Sternum Retractor Kits (Surgical Retractor Kits)", + "output": "something described as surgical retractor kits designed for use during procedures involving retraction of the sternum. These kits typically consist of a collection of devices, instruments, and supplies that are coupled together for temporary separation and retraction of sternum incision edges and, frequently, other anatomical parts (e.g., muscles), exposing and/or giving access to the thoracic organs without manual support once they are set (i.e., self-retained). The kits frequently include retractor frames, one or more sets of detachable (e.g., solid and toothed) blades, a ratchet mechanism, and fixation posts with nuts or screws. The kits may incorporate fiber optic systems to illuminate the surgical site. Sternum retractor kits provide hands-free assistance to the surgeon during open or minimally invasive procedures, especially those involving the heart and/or central vasculature." + }, + { + "input": "Concept: sputum cytology (Laboratory Procedure)", + "output": "Cytodiagnosis described as examination under a microscope of cells found in sputum (mucus and other matter brought up from the lungs by coughing). The test checks for abnormal cells, such as lung cancer cells." + }, + { + "input": "Concept: Skp1-protein-hydroxyproline N-acetylglucosaminyltransferase activity (catalytic activity, acting on a protein)", + "output": "catalytic activity, acting on a protein described as catalysis of the reaction: UDP-N-acetylglucosamine + Skp1-protein-hydroxyproline = UDP + Skp1-protein-O-(N-acetyl-D-glucosaminyl)hydroxyproline." + }, + { + "input": "Concept: tacrine HCl (Central Nervous System Agents)", + "output": "Product containing reversible anticholinesterase described as the hydrochloride salt form of tacrine, an aminoacridine derivative with cognitive stimulating property. Although the mechanism of action has not been fully elucidated, tacrine hydrochloride may bind reversibly to cholinesterase, acetylcholinesterase as well as butyrylcholinesterase, thereby decreasing the breakdown of acetylcholine, and prolonging synaptic actions as well as increased release of acetylcholine. In addition, this agent inhibits monoamine oxidase (MAO) and may inhibit the reuptake of catecholamines and serotonin. Finally, a novel mechanism of action studied in animal models suggests tacrine to attenuate the production of interleukin-1beta in the hippocampus and blood, thereby producing central and peripheral anti-inflammatory effects that may play a role in Alzheimer's disease." + }, + { + "input": "Concept: INFORMED CONSENT OBTAINED (Legal Issues)", + "output": "something described as an ongoing process that provides the subject with explanations that will help in making educated decisions about whether to begin or continue participating in a trial. informed consent is an ongoing, interactive process rather than a one-time information session. NOTE: Under 21 CFR 50.20, no informed consent form may include any \"language through which the subject or the representative is made to waive or appear to waive any of the subject's legal rights, or releases or appears to release the investigator, the sponsor, the institution, or its agents from liability for negligence.\" In some cases, when the prospective subject is unable to provide legal consent, permission to participate may be obtained from a legally-authorized representative. See also consent form." + }, + { + "input": "Concept: PedsQL Neuromuscular Module Version 3.0 Young Adult Report - Get Sick Easily (Intellectual Product)", + "output": "PedsQL Neuromuscular Module Version 3.0 Young Adult Report Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Version 3.0 Young Adult Report (PedsQL Neuromuscular Module Version 3.0 Young Adult Report) In the past one month, how much of a problem has this been for you: I get sick easily." + }, + { + "input": "Concept: Lung Cancer pT2a TNM Finding v7 (Finding)", + "output": "Lung Cancer pT2 TNM Finding v7 described as lung cancer with a tumor size more than 3 cm but 5 cm or less in greatest dimension." + }, + { + "input": "Concept: memory T cell activation (Cell Function)", + "output": "Cell Function described as the change in morphology and behavior of a memory T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." + }, + { + "input": "Concept: BRAF p.G466R (BRAF Protein Variant)", + "output": "Cell or Molecular Dysfunction described as a change in the amino acid residue at position 466 in the serine/threonine protein kinase B-raf protein where glycine has been replaced by arginine." + }, + { + "input": "Concept: C4HC3 Zinc Finger (Amino Acid Sequence)", + "output": "Metal Binding Site described as a C4HC3 zinc-finger-like motif, the PHD finger is found in nuclear proteins thought involved in chromatin-mediated transcriptional regulation. Single or multiple fingers are found. A specific function is not yet known, but it could be involved in protein-protein interactions important for assembly/activity of multi-component transcriptional regulatory complexes. In CBP it is an integral part of the acetyltransferase enzymatic core domain and contributes to CBP transcriptional activity. PHD fingers fold into an interleaved Zn-finger chelating two Zn ions in an atypical cross-braced conformation also shared by the FYVE and RING fingers; the zinc sites are located at opposite ends of a beta-sheet. Surrounding loops vary significantly in length and sequence between these three domains." + }, + { + "input": "Concept: PRKAR1A-RARA Fusion Protein (Amino Acid, Peptide, or Protein)", + "output": "something described as a fusion protein encoded by the PRKAR1A/RARA fusion gene. This protein is comprised of the N-terminal protein dimerization domain of the cAMP-dependent protein kinase type I-alpha regulatory subunit protein fused to the C-terminal DNA and ligand binding domains of the retinoic acid receptor alpha protein." + }, + { + "input": "Concept: urine cytology (Cytology procedure)", + "output": "Urinary tract histopathology procedures described as tests performed on cells in urine to detect disease." + }, + { + "input": "Concept: 2-(9-oxoacridin-10yl)acetic acid (Pharmaceutical Adjuvants)", + "output": "Biological Response Modifiers described as the sodium salt form of cridanimod, a small molecule that can increase progesterone receptor (PR) expression, with potential antineoplastic adjuvant activity. Upon intramuscular administration, cridanimod is able to induce the expression of PR in endometrial cancer. This could increase the sensitivity of endometrial cancer cells to progestin monotherapy. In combination with a progestin, cancer cells could be eradicated through increased PR-mediated signaling, leading to an inhibition of luteinizing hormone (LH) release from the pituitary gland, via a negative feedback mechanism, and, eventually, an inhibition of estrogen release from the ovaries. This leads to an inhibition of cellular growth in estrogen-dependent tumor cells. In addition, this agent is able to increase the production and release of interferon (IFN) alpha and beta. PR is often downregulated in endometrial cancer and makes it resistant to progestin-mediated hormone therapy." + }, + { + "input": "Concept: informed (Qualitative Concept)", + "output": "Qualitative Concept described as acquainted with knowledge of a subject." + }, + { + "input": "Concept: OBESE (Nutrition Disorders)", + "output": "Weight described as a condition marked by an abnormally high, unhealthy amount of body fat." + }, + { + "input": "Concept: methanol biosynthesis (primary alcohol biosynthetic process)", + "output": "primary alcohol biosynthetic process described as the chemical reactions and pathways resulting in the formation of methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent." + }, + { + "input": "Concept: ADL0118A (ADCS-ADL Questionnaire Question)", + "output": "something described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory - Was {S} left away from home, for 15 minutes or longer, during the day?" + }, + { + "input": "Concept: Mu Glutathione-S-Transferase (Laboratory Procedure)", + "output": "something described as a measurement of the mu form of glutathione S-transferase in a biological specimen." + }, + { + "input": "Concept: Allergy to dust mite protein (Infection by site)", + "output": "Communicable Diseases described as the disposition to develop an allergic reaction to a substance derived from dust mites e.g. Der p1, rather than the dust mite organism itself." + }, + { + "input": "Concept: MEXICO (North American country)", + "output": "North America described as a country in Central America, bordering the Caribbean Sea and the Gulf of Mexico, between Belize and the US and bordering the North Pacific Ocean, between Guatemala and the US." + }, + { + "input": "Concept: ommochrome breakdown (aromatic compound catabolic process)", + "output": "heterocycle catabolic process described as the chemical reactions and pathways resulting in the breakdown of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." + }, + { + "input": "Concept: Stage II Mycosis Fungoides and Sezary Syndrome AJCC v8 (Mycosis Fungoides and Sezary Syndrome by AJCC v8 Stage)", + "output": "Mycosis Fungoides and Sezary Syndrome by AJCC v8 Stage described as stage II includes: IIA (T1,2, N1,2, M0, B0,1); IIB (T3, N0-2, M0, B0,1). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. T2: Patches, papules, or plaques covering 10% or more of the skin surface. T3: One or more tumors (equal or greater than 1 cm in diameter). N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or National Cancer Institute (NCI) LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2." + }, + { + "input": "Concept: Systemic venous circulatory system (Body System)", + "output": "Systemic circulatory system described as subdivision of cardiovascular system which has as its parts the right side of heart, the superior vena cava and the inferior vena cava." + }, + { + "input": "Concept: Do Not Want to Download Apps to Personal Smartphone or Tablet for the Trial (Finding)", + "output": "Clinical or Research Assessment Answer described as a response indicating that an individual does not want to download apps to their personal smartphone or tablet for the trial." + }, + { + "input": "Concept: PODCI3-Happiness Scale (PODCI Adolescent Self-Reported Version Questionnaire Question)", + "output": "something described as pediatric Outcomes Data Collection Instrument, Adolescent Self-Reported Version (PODCI Adolescent Self-Reported Version) Happiness core scale." + }, + { + "input": "Concept: Product containing ethinylestradiol (Pharmacologic Substance)", + "output": "Contraceptives, Oral described as semisynthetic alkylated estradiol with a 17-alpha-ethinyl substitution; has high estrogenic potency when administered orally, and is often used as the estrogenic component in oral contraceptives." + }, + { + "input": "Concept: Ledderhose's Disease (inflammatory soft tissue disorders)", + "output": "Connective tissue disorder by body site described as a fibromatosis of the plantar fascia characterized by thickening of the fibrous bands on the plantar aponeurosis in the sole of the foot and toes." + }, + { + "input": "Concept: pericanalicular vesicle (Cytoplasmic Vesicles)", + "output": "Cytoplasmic Vesicles described as a membrane-bounded vesicle found near the apical, or pericanalicular, membrane of a hepatocyte; contains proteins involved in bile salt transport and other fluid and solute transport processes." + }, + { + "input": "Concept: Monotonic speech (Finding)", + "output": "something described as a speech pattern characterized by abnormally reduced or lacking variability of the pitch of the voice. []" + }, + { + "input": "Concept: Atezolizumab product (Immunologic Factor)", + "output": "Programmed cell death protein 1 inhibitor-containing product described as a humanized, Fc optimized, monoclonal antibody directed against the protein ligand PD-L1 (programmed cell death-1 ligand 1), with potential immune checkpoint inhibitory and antineoplastic activities. Atezolizumab binds to PD-L1, blocking its binding to and activation of its receptor programmed death 1 (PD-1) expressed on activated T-cells, which may enhance the T-cell-mediated immune response to neoplasms and reverse T-cell inactivation. In addition, by binding to PD-L1, atezolizumab also prevents binding of this ligand to B7.1 expressed on activated T cells, which further enhances the T-cell-mediated immune response. PD-L1 is overexpressed on many human cancer cell types and on various tumor-infiltrating immune cells. PD-L1 binding to PD-1 on T-cells suppresses the immune system and results in increased immune evasion. PD-1, a transmembrane protein, is a negative regulator of the immune system that limits the expansion and survival of CD8+ T cells. The Fc region of atezolizumab is modified in such a way that it does not induce either antibody-dependent cytotoxicity (ADCC) or complement-dependent cytotoxicity (CDC). Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C106250\" active clinical trials using this agent." + }, + { + "input": "Concept: Internet Website (Intellectual Product)", + "output": "something described as a collection of web pages and other files. A site can consist of a single web page, thousands of pages, or custom created pages that draw on a database associated with the site." + }, + { + "input": "Concept: Recurrent Laryngeal Nerve Palsy (Finding)", + "output": "something described as a disorder characterized by paralysis of the recurrent laryngeal nerve." + }, + { + "input": "Concept: response to actidione (response to ketone)", + "output": "response to fungicide described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloheximide stimulus. Cycloheximide (actidione) is an antibiotic produced by some Streptomyces species which interferes with protein synthesis in eukaryotes." + }, + { + "input": "Concept: Grade 3 Neonatal Sinus Bradycardia, Adverse Event (Finding)", + "output": "Neonatal Sinus Bradycardia, Adverse Event described as an adverse event in a newborn characterized by persistent sinus bradycardia; resulting in non-life threatening hemodynamic compromise; requiring major care changes (e.g. new medication or intervention)." + }, + { + "input": "Concept: Beta globulin (Proteins)", + "output": "Globulins described as a type of globulin in plasma that in electrically charged solutions exhibits colloidal mobility between that of the alpha and gamma globulins." + }, + { + "input": "Concept: BEBQ Retrospective Version - Baby Fed Slowly (BEBQ Retrospective Version Questionnaire Question)", + "output": "Intellectual Product described as baby Eating Behaviour Questionnaire Retrospective Version (BEBQ Retrospective Version) My baby fed slowly." + }, + { + "input": "Concept: FAC036-Bothered by Treatment Side Effect (NCCN-FACT FHNSI-22 Version 2 Questionnaire Question)", + "output": "Intellectual Product described as national Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Head & Neck Symptom Index-22 Version 2 - I am bothered by side effects of treatment." + }, + { + "input": "Concept: cellular response to sulfur starvation (Cell Function)", + "output": "cellular response to starvation described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfur." + }, + { + "input": "Concept: Cricothyroid muscle (Body Part, Organ, or Organ Component)", + "output": "Skeletal muscle structure of neck described as a muscle originating from the cricoid arch on the anterior surface in which the posterior section runs outward to the thyroid's inferior horn and the anterior section runs upward to the thyroid's ala. The cricothyroid muscle is innervated by the superior laryngeal nerve's external branch and acts to tense the vocal cords thus altering voice pitch." + }, + { + "input": "Concept: Corpus pancreatis (Region of pancreas)", + "output": "Subdivision of pancreas described as the part of the pancreas from the point where it crosses the portal vein to the point where it enters the lienorenal ligament." + }, + { + "input": "Concept: Recurrent Submandibular Gland Carcinoma (Carcinoma of submandibular gland)", + "output": "Neoplastic Process described as the reemergence of submandibular gland carcinoma after a period of remission." + }, + { + "input": "Concept: FSHB wt Allele (Gene or Genome)", + "output": "FSHB gene described as human FSHB wild-type allele is located in the vicinity of 11p13 and is approximately 4 kb in length. This allele, which encodes follitropin subunit beta protein, is involved in induction of sperm and egg production. Mutations in this gene are associated with follicle-stimulating hormone deficiency, isolated." + }, + { + "input": "Concept: DNA Binding Protein CTCF (Biologically Active Substance)", + "output": "Poly-ADP-Ribose Binding Proteins described as a repressor protein with poly(ADP)-ribose binding activity that binds CHROMATIN and DNA; its structure consisting of 11 CYS2-HIS2 ZINC FINGERS allows it to recognize many different DNA target sites. It functions as a repressor by binding to INSULATOR ELEMENTS and preventing interaction between promoters and nearby enhancers and silencers. It plays a critical role in EPIGENETIC PROCESSES, including GENOMIC IMPRINTING." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, PAH (Medical Device)", + "output": "something described as molecular assay reagents intended to identify mutations in the phenylalanine hydroxylase (PAH) gene, located at chromosome 12q22-q24.2, which encodes for the enzyme phenylalanine hydroxylase. The enzyme is responsible for the first step in processing phenylalanine, an amino acid obtained through the diet. Mutations at this locus have been identified in patients with phenylketonuria (PKU)." + }, + { + "input": "Concept: Plasmablastic Lymphoma of the Oral Cavity (Plasmablastic Lymphoma of Mucosa Site)", + "output": "something described as a plasmablastic lymphoma arising in the oral cavity, usually associated with HIV infection." + }, + { + "input": "Concept: T-cell ubiquitin ligand-2, human (Biologically Active Substance)", + "output": "Protein Tyrosine Phosphatase described as ubiquitin-associated and SH3 domain-containing protein B (649 aa, ~73 kDa) is encoded by the human UBASH3B gene. This protein plays a role in the dephosphorylation of tyrosine kinases." + }, + { + "input": "Concept: nucleotide-sulfate transmembrane transporter activity (Molecular Function)", + "output": "Molecular Function described as enables the transfer of nucleotide-sulfate from one side of a membrane to the other." + }, + { + "input": "Concept: Measurement of prostaglandin (Fatty acid measurement)", + "output": "Hormone measurement described as the determination of the amount of the total prostaglandin in a sample." + }, + { + "input": "Concept: ganglion formation (Organ or Tissue Function)", + "output": "Organ or Tissue Function described as the process that gives rise to ganglion. This process pertains to the initial formation of a structure from unspecified parts." + }, + { + "input": "Concept: Fatigue Rating Score 4 (Intellectual Product)", + "output": "something described as a subjective score of 4 on a fatigue scale that ranges from 0: No Fatigue to 10: Fatigue as bad as you can imagine." + }, + { + "input": "Concept: positive regulation of anaphase-promoting complex-dependent catabolic process (positive regulation of proteasomal ubiquitin-dependent protein catabolic process)", + "output": "positive regulation of proteasomal ubiquitin-dependent protein catabolic process described as any process that activates or increases the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process." + }, + { + "input": "Concept: h*mol/L/m2 (Measurement Unit Description)", + "output": "something described as hours times moles per liter, divided by meters squared." + }, + { + "input": "Concept: PGI Generic Modification Version (Intellectual Product)", + "output": "Intellectual Product described as patient Global Impression (PGI) generic modification for any disease/condition concept use case (Modified from Guy W: ECDEU Assessment Manual for Psychopharmacology. Rockville, MD: U.S. Department of Health, Education, and Welfare; 1976)." + }, + { + "input": "Concept: Coagulation Factor II (Vitamin K dependent procoagulant)", + "output": "Amino Acid, Peptide, or Protein described as a plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia." + }, + { + "input": "Concept: Oral fibrous bands (Finding)", + "output": "Finding described as fibrous band between the mucosal surfaces of the upper and lower alveolar ridges." + }, + { + "input": "Concept: Rhodosphaera capsulata (Bacterium)", + "output": "something described as spherical phototrophic bacteria found in mud and stagnant water exposed to light." + }, + { + "input": "Concept: Service Delivery Location Code (Code)", + "output": "something described as a coded value specifying the kind of service delivery location. EXAMPLE(S): incidental, dedicated, clinical, non-clinical OTHER NAME(S): NOTE(S): A service delivery location may be either an incidental service delivery location (a place at which services may be provided without prior designation or authorization) or a dedicated service delivery location (a place that is intended to house the provision of services). Dedicated service delivery locations can be further characterized as either clinical or non-clinical." + }, + { + "input": "Concept: aurachin C epoxide hydrolase/isomerase activity (ether hydrolase activity)", + "output": "Molecular Function described as catalysis of the reaction: aurachin C epoxide + H+ + NAD(P)H <=> aurachin B + H2O + NAD(P)." + }, + { + "input": "Concept: 20 Pack (Package Dosing Unit)", + "output": "Quantitative Concept described as a product containing twenty individual units." + }, + { + "input": "Concept: Colon Kaposis Sarcoma (Colorectal Kaposi Sarcoma)", + "output": "Colon Sarcoma described as a Kaposi sarcoma arising from the colon." + }, + { + "input": "Concept: Endoscopic Suturing Systems, Lower Esophageal Sphincter (Suture Units, Automated)", + "output": "something described as endoscopic automated suture units designed for mounting on an endoscope used to suture the tissues in the lower esophageal sphincter during endoluminal gastroplication procedures. The devices typically consist of a suture-delivery mechanism, frequently including a capsule chamber that contains needles, a suture-carrier accessory, and a handle to manipulate the equipment and control the suture delivery. The devices place the stitches and create pleats in the lower esophageal sphincter. Lower esophageal sphincter endoscopic suture units are mainly used to tighten the lower esophageal sphincter to reduce acid reflux for patients with gastroesophageal reflux disease." + }, + { + "input": "Concept: PODCI Adolescent Parent-Reported Version - Outdoor Limited by: Dislike (PODCI Adolescent Parent-Reported Version Questionnaire Question)", + "output": "Intellectual Product described as pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported - If you answered \"no\" to Question 36 above, was your child's activity limited by: Dislike of recreational outdoor activities?" + }, + { + "input": "Concept: Activating Transcription Factor 3 (Cyclic AMP-Responsive DNA-Binding Protein)", + "output": "something described as cyclic AMP-dependent transcription factor ATF-3 (181 aa, ~21 kDa) is encoded by the human ATF3 gene. This protein plays a role in both DNA binding and the repression of gene expression." + }, + { + "input": "Concept: CENP-E Inhibitor GSK-923295 (Antimitotic Agents)", + "output": "something described as a small-molecule inhibitor of the mitotic kinesin centromere-associated protein E (CENP-E), with potential antineoplastic activity. Upon administration, GSK-923295 binds to and inhibits CENP-E, thereby preventing cell division, inducing cell cycle arrest, and ultimately leading to an inhibition of cell proliferation. CENP-E, a kinetochore-associated mitotic kinesin, plays an essential role in chromosome movement during mitosis and regulates cell-cycle transition from metaphase to anaphase." + }, + { + "input": "Concept: cells parafollicular (Parenchyma of left lobe of thyroid gland)", + "output": "Parenchyma of right lobe of thyroid gland described as a neuroendocrine cell found in the thyroid gland interspersed among the follicular cells or in clusters between the follicles. It produces and secretes calcitonin in response to its calcium receptor." + }, + { + "input": "Concept: 19: 12653677-12647534 (Chromosome 19 Physical Location)", + "output": "something described as physical location of DHPS_Gene" + }, + { + "input": "Concept: Ribbon (Manufactured Object)", + "output": "Device Component or Accessory described as any device that consists of a long, narrow, flexible material." + }, + { + "input": "Concept: FAC062 (Clinical or Research Assessment Questionnaire)", + "output": "something described as a standardized 40-item self-report rating scale to measure quality of life in cancer patients receiving treatment with biologic response modifiers that is divided into six subscales: physical, social/family, emotional, and functional well-being, as well as two subscales related to physical and mental symptoms common to treatment with biologic response modifiers. Originally developed by Cella, et al. in 1997, it combines the Functional Assessment of Cancer Therapy - General (FACT-G), and two Biologic Response Modifier (BRM) subscales." + }, + { + "input": "Concept: Immunopotentiators (Pharmacologic Substance)", + "output": "Immunologic Factors described as a diversity of reagents employed for nonspecific active immunization; used to enhance the immune response; 4 major groups: bacterial products, synthetic molecules, cytokines, and hormones." + }, + { + "input": "Concept: aversion conditioning therapy (Conditioning)", + "output": "Conditioning described as conditioning paradigm in which aversive effects are paired with external stimuli resulting in an aversion to the stimuli. Also, the learned aversion itself." + }, + { + "input": "Concept: Neoplasm of Anterior Tongue (Tongue Neoplasms)", + "output": "Tongue Neoplasms described as a benign or malignant neoplasm that affects the anterior portion of the tongue." + }, + { + "input": "Concept: Increased sensitivity to ionising radiation (Finding)", + "output": "something described as an abnormally increased sensitivity to the effects of ionizing radiation." + }, + { + "input": "Concept: Large pelvis bone (Anatomical Abnormality)", + "output": "something described as the presence of an abnormally large pelvis." + }, + { + "input": "Concept: Periocular blast injury (Injury of eye region)", + "output": "something described as injury to any structure of the eyelids, eye and optic nerve, including penetrating injury, from exposure to a blast source." + }, + { + "input": "Concept: Marker of Preneoplastic Change (Finding)", + "output": "Disease Marker described as specific molecular molecules or signatures that indicate that a cell will become neoplastic at a future time." + }, + { + "input": "Concept: Extensively Drug-Resistant Mycobacterium tuberculosis (Bacterium)", + "output": "something described as a strain of Mycobacterium tuberculosis that is resistant to all of the following: isoniazid, rifampin, any of the fluoroquinolone antibiotics, and at least one of three injectable drugs (kanamycin, capreomycin, amikacin)." + }, + { + "input": "Concept: Development Planning (Intellectual Product)", + "output": "Planned described as an ordered program of clinical trials, each with specific objectives. [adapted from ICH E9, see ICH E8]. See also clinical development plan." + }, + { + "input": "Concept: KIAA0068 (Gene or Genome)", + "output": "Gene or Genome described as this gene plays a role in both translational repression and actin filament reorganization." + }, + { + "input": "Concept: Recurrent respiratory tract infections (Recurrent upper respiratory tract infection)", + "output": "something described as increased susceptibility to upper and lower respiratory tract infections, as manifested by recurrent episodes of upper and lower respiratory tract infections. []" + }, + { + "input": "Concept: Hemophagocytosis (Disease or Syndrome)", + "output": "Physical shape described as phagocytosis by macrophages of erythrocytes, leukocytes, platelets, and their precursors in bone marrow and other tissues." + }, + { + "input": "Concept: Size Reduction Particle Sizing (Laboratory Procedure)", + "output": "Particle Size described as reduction of particle size to a coarse or fine dry powder by applying mechanical force involving grinding, attrition, or impact, where screening may be integral to size reduction; usually performed to de-agglomerate purified powders without changing the crystal size." + }, + { + "input": "Concept: Odontohypophosphatasia (Hypophosphatasia)", + "output": "Autosomal recessive hereditary disorder described as tooth specific inherited disorder of mineral metabolism caused by gene mutation, encoding tissue non-specific alkaline phosphatase (TNAP)." + }, + { + "input": "Concept: IL2 Gene (Gene or Genome)", + "output": "something described as this gene is involved in growth and lymphokine regulation." + }, + { + "input": "Concept: activity electrical (Neurophysiology - biologic function)", + "output": "CEREBRAL FUNCTIONS AND DYSFUNCTIONS described as electrically measured responses or response patterns, usually of individual units (i.e., cells) or groups of cells, in any part of the nervous system. Includes neural or neuron impulses; neural depolarization or hyperpolarization; spike, resting, action, generator, graded, presynaptic, or postsynaptic potentials. Compare ELECTROPHYSIOLOGY." + }, + { + "input": "Concept: CCR4-NOT complex (protein-containing complex)", + "output": "Cell Component described as the Ccr4-Not complex is an eukaryotically conserved deadenylase that can initiate cytoplasmic mRNA decay, and reduce translation by releasing poly(A)-binding protein (Pab1/PABPC1). Ccr4-Not contains seven core subunits, including two poly(A)-specific exonucleases, Ccr4/CNOT6/CNOT6L and Caf1/Pop2/CNOT7/CNOT8." + }, + { + "input": "Concept: Tear duct (EYES AND EYE APPENDAGES)", + "output": "Body part described as organ with organ cavity which connects the vestibule of the conjunctival sac to the nasal cavity. Examples: There are only two lacrimal ducts, the right and the left lacrimal ducts." + }, + { + "input": "Concept: Global Alignment of Immunization safety Assessment in pregnancy Level 2b Small for Gestational Age (Intellectual Product)", + "output": "Intellectual Product described as GAIA Level 2b Small for Gestational Age is defined by three criteria: first, weight below the 10th percentile for gestational age; second, the newborn weighed within 24 hours on any scale with a less than or equal to 50 g resolution, calibrated and tared to zero; third, gestational age determined by uncertain LMP with second trimester ultrasound." + }, + { + "input": "Concept: macropexophagy (selective autophagy)", + "output": "something described as the selective autophagy process in which a peroxisome is degraded by macroautophagy." + }, + { + "input": "Concept: Phoca groenlandica (Mammal)", + "output": "Genus Phoca described as the best known species of earless seals, inhabiting the North Atlantic and Arctic Oceans. Harp seals get their name from a horse-shaped band of black fur on the back of the male adults. They were previously considered part of the genus Phoca." + }, + { + "input": "Concept: GHB Measurement (Laboratory Procedure)", + "output": "something described as the determination of the amount of gamma-hydroxybutyrate (GHB) present in a sample." + }, + { + "input": "Concept: MRD Persistence (Finding)", + "output": "Finding described as presence of residual disease based on pre-defined thresholds and quantifiable MRD positivity by laboratory techniques." + }, + { + "input": "Concept: mannitol:NAD+ 1-oxidoreductase activity (Molecular Function)", + "output": "oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor described as catalysis of the reaction: D-mannitol + NAD(+) = D-mannose + H(+) + NADH." + }, + { + "input": "Concept: Trans fat (Food)", + "output": "Dietary Fatty Acid described as a class of dietary fatty acids containing at least one double bond in the trans formation." + }, + { + "input": "Concept: Indirect Transmission (Pathologic Function)", + "output": "Contact Transmission described as the transmission of an infectious agent from a source to a host through an intermediary such as inanimate objects (vehicles) or living organisms (vectors)." + }, + { + "input": "Concept: acetyl-coenzyme A:acetyl alcohol acetyltransferase activity (transferase activity, transferring acyl groups other than amino-acyl groups)", + "output": "transferase activity, transferring acyl groups other than amino-acyl groups described as catalysis of the reaction: benzyl alcohol + acetyl-CoA = benzyl acetate + coenzyme A." + }, + { + "input": "Concept: Nociceptive Stimulus (Sensory Process)", + "output": "Molecular Function described as an impulse that gives rise to sensations of pain." + }, + { + "input": "Concept: D-amino-acid dehydrogenase complex location (Cell Component)", + "output": "Cell Component described as a protein complex that possesses D-amino-acid dehydrogenase activity." + }, + { + "input": "Concept: cis Golgi network (Golgi Apparatus)", + "output": "Cell Component described as a network of membrane components where vesicles from the endoplasmic reticulum fuse with the Golgi apparatus." + }, + { + "input": "Concept: Law, Natural (Idea or Concept)", + "output": "Idea or Concept described as rules of conduct derived from nature and considered to be binding upon human society in the absence of, or in addition to, institutional law." + }, + { + "input": "Concept: Total CL Pred Norm by BMI (Predicted Total Body Clearance Rate)", + "output": "Quantitative Concept described as the predicted total body clearance for intravascular administration divided by the body mass index." + }, + { + "input": "Concept: Testicular Cancer pM1 TNM Finding v7 (Testicular Cancer Pathologic Distant Metastasis TNM Finding v7)", + "output": "Finding described as testicular cancer with distant metastasis." + }, + { + "input": "Concept: ANAEROBIC COCCUS (Microorganism)", + "output": "Bacterium described as any spherical shaped bacteria that does not require oxygen to grow or respirate." + }, + { + "input": "Concept: Flow Microfluorometry (Blood Cell Count)", + "output": "Cytophotometry described as a method of measuring the number of cells in a sample, the percentage of live cells in a sample, and certain characteristics of cells, such as size, shape, and the presence of tumor markers on the cell surface. The cells are stained with a light-sensitive dye, placed in a fluid, and passed in a stream before a laser or other type of light. The measurements are based on how the light-sensitive dye reacts to the light." + }, + { + "input": "Concept: cyclohex-1-ene-1-carboxyl-CoA hydratase activity (Molecular Function)", + "output": "hydro-lyase activity described as catalysis of the reaction: cyclohex-1-ene-1-carboxyl-CoA + H2O = 2-hydroxycyclohexane-1-carboxyl-CoA." + }, + { + "input": "Concept: Se2+ (Dietary Selenium)", + "output": "Element, Ion, or Isotope described as selenium ion requiring two electrons to return to its elemental state." + }, + { + "input": "Concept: Segment Score 0 (Finding)", + "output": "Finding described as unprepared colon segment with mucosa not seen due to solid stool that cannot be cleared." + }, + { + "input": "Concept: Marfan syndrome (Family history)", + "output": "Family history of hereditary disease described as a genetic syndrome inherited as an autosomal dominant trait. It is caused by mutations in the FBN1 gene. It is characterized by tall stature, elongated extremities, mitral valve prolapse, aortic dilatation, aortic dissection, and subluxation of the lens. Diagnosis is made based on the 2010 Revised Ghent Nosology for Marfan syndrome" + }, + { + "input": "Concept: FZR1 gene (Genes, cdc)", + "output": "Genes, cdc described as this gene is involved in the regulation of protein ubiquitination and the cell cycle." + }, + { + "input": "Concept: Chemical Or Drug Affects Cell Type Or Tissue (Idea or Concept)", + "output": "Idea or Concept described as a role used to represent the intended target cells for a chemical or drug. This does not include unintended target cells or tissues that are associated with side effects or toxicity of the chemical or drug. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Anatomic Structure, System, or Substance', respectively." + }, + { + "input": "Concept: Acholeplasma Edward and Freundt 1970 (Acholeplasma)", + "output": "Mycoplasmatales described as a genus of gram-negative organisms including saprophytic and parasitic or pathogenic species." + }, + { + "input": "Concept: QEVAL (Professional or Occupational Group)", + "output": "Evaluator - personnel described as a person who determines the significance of a qualifier." + }, + { + "input": "Concept: cellular nickel ion homeostasis (nickel cation homeostasis)", + "output": "cellular transition metal ion homeostasis described as any process involved in the maintenance of an internal steady state of nickel ions at the level of a cell." + }, + { + "input": "Concept: AR II (Medical Device)", + "output": "Medical Device described as amplatz right II" + }, + { + "input": "Concept: Nurse usual existing home-visit 25 minutes (Health Care Activity)", + "output": "Existing client home-visit with nursing diagnosis described as assessing and/or managing an existing client using nursing diagnoses in a usual, 25-minute home-visit. Use this code to describe advanced nursing care without physician oversight. The client may or may not have a medical diagnosis." + }, + { + "input": "Concept: Phytolaccas (Plant)", + "output": "Plant described as a plant genus of the family PHYTOLACCACEAE, order Caryophyllales." + }, + { + "input": "Concept: PANSS117 (Intellectual Product)", + "output": "something described as positive and Negative Syndrome Scale - Guilt feelings." + }, + { + "input": "Concept: SYRINGE, RESTORATIVE AND IMPRESSION MATERIAL (Medical Device)", + "output": "Medical Device described as a dental hand instrument is a hand-held device intended to perform various tasks in general dentistry and oral surgery procedures. The device includes the operative burnisher, operative amalgam carrier, operative dental amalgam carver, surgical bone chisel, operative amalgam and foil condenser, endodontic curette, operative curette, periodontic curette, surgical curette, dental surgical elevator, operative dental excavator, operative explorer surgical bone file, operative margin finishing file, periodontic file, periodontic probe, surgical rongeur forceps, surgical tooth extractor forceps, surgical hemostat, periodontic hoe, operative matrix contouring instrument, operative cutting instrument, operative margin finishing periodontic knife, periodontic marker, operative pliers, endodontic root canal plugger, endodontic root canal preparer, surgical biopsy punch, endodontic pulp canal reamer, crown remover, periodontic scaler, collar and crown scissors, endodontic pulp canal filling material spreader, surgical osteotome chisel, endodontic broach, dental wax carver, endodontic pulp canal file, hand instrument for calculus removal, dental depth gauge instrument, plastic dental filling instrument, dental instrument handle, surgical tissue scissors, mouth mirror, orthodontic band driver, orthodontic band pusher, orthodontic band setter, orthodontic bracket aligner, orthodontic pliers, orthodontic ligature tucking instrument, forceps, for articulation paper, forceps for dental dressing, dental matrix band, matrix retainer, dental retractor, dental retractor accessories, periodontic or endodontic irrigating syringe, and restorative or impression material syringe." + }, + { + "input": "Concept: Endoplasmic Reticulum Interferon Stimulator (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as stimulator of interferon genes protein (379 aa, ~42 kDa) is encoded by the human STING1 gene. This protein plays a role in the modulation of both innate immune responses and signal transduction." + }, + { + "input": "Concept: Mechlorethamine HCl Gel (Nitrogen Mustard Antineoplastic Compounds)", + "output": "something described as a gel formulation composed of the hydrochloride salt form of mechlorethamine, which is a nitrogen mustard alkylating agent and an analog of sulfur mustard, with antineoplastic and immunosuppressive activities. Upon topical application, mechlorethamine is metabolized to an unstable, highly reactive ethyleniminium intermediate that binds to and alkylates DNA, with a high affinity to the N7 nitrogen of guanine residues. This results in DNA base pair mismatching, DNA interstrand crosslinking, the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C119736\" active clinical trials using this agent." + }, + { + "input": "Concept: PSDEPHD (Ethanol measurement)", + "output": "CNS Stimulant Drug Measurement described as the determination of the amount of pseudoephedrine present in a sample" + }, + { + "input": "Concept: Colchicine-Site Binding Agent ABT-751 (Organic Chemical)", + "output": "Pharmacologic Substance described as a substance that is being studied as a treatment for cancer. It belongs to the family of drugs called sulfonamides." + }, + { + "input": "Concept: Proto-Oncogene c-ErbB-1 M766 A767insASV (EGFR Protein Variant)", + "output": "Cell or Molecular Dysfunction described as an insertion of the amino acid sequence alanine-serine-valine between the methionine at position 766 and the alanine at position 767 of the epidermal growth factor receptor protein." + }, + { + "input": "Concept: Needles, Injection, Cystoscopic (Medical Device)", + "output": "Medical Device described as injection needles designed to penetrate into the urethra and/or the urinary bladder neck or wall during cystoscopic procedures. These devices typically consist of 23-gauge needles, 35 to 45 cm (14 to 18 inches) in length, with appropriate 7 to 8 mm tips to minimize cutting and/or lesion of adjacent tissues and nerves. Cystoscopic injection needles are frequently intended to administer filling materials such as collagen to treat stress urinary incontinence; they are also used to inject Teflon and/or other polymers in the treatment of vesicoureteral reflux." + }, + { + "input": "Concept: Study Site Temporarily Closed to Accrual and Intervention (Qualitative Concept)", + "output": "something described as trial is temporarily not accruing and patients are not receiving therapy/intervention." + }, + { + "input": "Concept: DRRI-2 - I: Had Family I Could Talk To (Intellectual Product)", + "output": "something described as deployment Risk & Resilience Inventory-2 - During deployment: I had family members or friends at home I could talk to when I had a problem." + }, + { + "input": "Concept: UDP-L-rhamnose synthase activity (transferase activity)", + "output": "something described as catalysis of the reaction: UDP-D-glucose + NADPH + H+ = UDP-L-rhamnose + NADP+ + H2O." + }, + { + "input": "Concept: AIDS-Related Non-Hodgkin's Lymphoma (Neoplastic Process)", + "output": "Lymphoma, AIDS-Related described as a non-Hodgkin lymphoma that develops in a patient with AIDS." + }, + { + "input": "Concept: Picrorhiza Royle ex Benth. (Plantaginaceae)", + "output": "Scrophulariaceae described as a plant genus of the family Plantaginaceae. Members contain scrosides (CINNAMATES) and phenylethanoid glycoside. P. kurrooa is the source of picroliv (a purified iridoid glycoside fraction from the roots having hepatoprotective, anti-inflammatory and antioxidant properties)." + }, + { + "input": "Concept: Readiness to Quit Smoking Score 9 (Finding)", + "output": "something described as a subjective score of 9 on a scale that ranges from 0: I am not ready to quit to 10: I am ready to quit now." + }, + { + "input": "Concept: Apoptosis Induction (regulation of apoptotic process)", + "output": "something described as any cellular process that increases the frequency, rate or extent of cell death by apoptosis." + }, + { + "input": "Concept: Neuropathy due to diabetes mellitus (Complications of Diabetes Mellitus)", + "output": "something described as peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy." + }, + { + "input": "Concept: height (systemic symptoms)", + "output": "Body measure procedure described as vertical measurement value." + }, + { + "input": "Concept: pore complex location (Other Anatomic Concept)", + "output": "Cell Component described as any small opening in a membrane that allows the passage of gases and/or liquids." + }, + { + "input": "Concept: DNA Nucleotidylexotransferase (Enzymes)", + "output": "nucleotidyltransferase described as a non-template-directed DNA polymerase normally found in vertebrate thymus and bone marrow. It catalyzes the elongation of oligo- or polydeoxynucleotide chains and is widely used as a tool in the differential diagnosis of acute leukemias in man. EC 2.7.7.31." + }, + { + "input": "Concept: Soft Tissue Sarcoma of the Head and Neck TNM Finding v8 (Soft Tissue Sarcoma TNM Finding v8)", + "output": "something described as a finding about one or more characteristics of soft tissue sarcoma of the head and neck, following the rules of the TNM AJCC v8 classification system. This classification system applies to soft tissue sarcomas of the head and neck except angiosarcoma, rhabdomyosarcoma of the embryonal and alveolar subtype, Kaposi sarcoma, and dermatofibrosarcoma protuberans, which do not share the same behavior and natural history. This is a new classification system that needs data collection before defining a stage grouping for head and neck sarcomas. Sarcomas of the orbit are staged according to the orbital sarcoma classification system." + }, + { + "input": "Concept: newton (Derived Unit of International System of Units)", + "output": "Derived Unit of International System of Units described as a unit of force which, when applied in a vacuum to a body having a mass of one kilogram, causes an acceleration of one meter per second squared. It is equal to 1E5 dynes." + }, + { + "input": "Concept: Class V Surface (Tooth Components)", + "output": "Tooth Components described as the gingival margins of the tooth surfaces." + }, + { + "input": "Concept: ltr W undef.Wstrn hrb&ntrl s (Plant)", + "output": "Plant described as any elsewhere undefined Western herb and natural substance, letter W, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com." + }, + { + "input": "Concept: response to IL-6 (Cell Function)", + "output": "response to cytokine described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." + }, + { + "input": "Concept: Communicable disease management (Public health service)", + "output": "Infectious disease prevention / control described as providing a community's members with education and/or information regarding communicable disease(s) to prevent and/or minimize their community's incidence and/or prevalence of a communicable disease(s)." + }, + { + "input": "Concept: Compounds, Anti-Bacterial (Medicinal product categorized by therapeutic role)", + "output": "Medicinal product categorized by therapeutic role described as a family of substances capable of destroying or inhibiting the growth of bacteria." + }, + { + "input": "Concept: Rollinia (Annoneae)", + "output": "Plant described as a plant genus of the family ANNONACEAE. Members contain aporphines, acetogenins and rollinone." + }, + { + "input": "Concept: Nucleus Parabrachialis Laterali (Body Part, Organ, or Organ Component)", + "output": "Body Part, Organ, or Organ Component described as one of three or four components (in different species) of the parabrachial nuclei of the pontine tegmentum. It is located adjacent to the lateral surface of the superior cerebellar peduncle of the pons. In the human it is subdivided into four parts: central, dorsal, external, and superior ( Paxinos-2012 ). In the macaque it has central, dorsal, external, and ventral parts ( Paxinos-2009a ). \\r\\nIn rodents it is more differentiated. In the rat seven parts are identified: central, dorsal, external, extreme, internal, superior, and ventral ( Swanson-2004 ); in the mouse it has five: central, dorsal, external, superior, and ventral ( Dong-2004 ). Some authors find an internal part in the mouse as well ( Franklin-2008 ). Functionally the nucleus belongs to the viscerosensory nuclei ( Swanson-2004 )." + }, + { + "input": "Concept: Endarterectomies (Arterial therapeutic procedures)", + "output": "Excision of artery described as surgical excision, performed under general anesthesia, of the atheromatous tunica intima of an artery. When reconstruction of an artery is performed as an endovascular procedure through a catheter, it is called ATHERECTOMY." + }, + { + "input": "Concept: Comedocarcinoma NOS (Carcinoma)", + "output": "Neoplasms, Ductal, Lobular, and Medullary described as a high grade carcinoma characterized by the presence of comedo-type tumor cell necrosis in which the necrotic areas are surrounded by a solid proliferation of malignant pleomorphic cells." + }, + { + "input": "Concept: beta-1,3 glucan synthesis (Molecular Function)", + "output": "Molecular Function described as the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds." + }, + { + "input": "Concept: maxT Test (Quantitative Concept)", + "output": "Quantitative Concept described as a statisical test to adjust the p-value for multiple comparisons." + }, + { + "input": "Concept: FIBRINOGEN DETERMINATION STANDARDS AND CONTROLS (Indicator, Reagent, or Diagnostic Aid)", + "output": "Indicator, Reagent, or Diagnostic Aid described as a fibrinogen determination system is a device that consists of the instruments, reagents, standards, and controls used to determine the fibrinogen levels in disseminated intravascular coagulation (nonlocalized clotting within the blood vessels) and primary fibrinolysis (the dissolution of fibrin in a blood clot)." + }, + { + "input": "Concept: Submucosal Route of Drug Administration (Drug Administration Routes)", + "output": "RouteBySite described as administration of a drug beneath the mucous membrane." + }, + { + "input": "Concept: APPARATUS, CAUTERY, RADIOFREQUENCY, AC-POWERED (Medical Device)", + "output": "something described as a radiofrequency electrosurgical cautery apparatus is an AC-powered or battery-powered device intended for use during ocular surgery to coagulate tissue or arrest bleeding by a high frequency electric current." + }, + { + "input": "Concept: oxoglutarate dehydrogenase complex location (transferase complex)", + "output": "transferase complex described as a complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)." + }, + { + "input": "Concept: DNA polymerase epsilon complex (DNA polymerase complex)", + "output": "Cell Component described as a heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair." + }, + { + "input": "Concept: floor plate morphogenesis (tissue morphogenesis)", + "output": "tissue morphogenesis described as the process in which the anatomical structure of the floor plate is generated and organized." + }, + { + "input": "Concept: Patient Alert (General Qualifier)", + "output": "General Qualifier described as patient alert." + }, + { + "input": "Concept: Ubiquitin carboxy-terminal esterase (Hydrolase)", + "output": "Enzyme described as a thioester hydrolase which acts on esters formed between thiols such as DITHIOTHREITOL or GLUTATHIONE and the C-terminal glycine residue of UBIQUITIN." + }, + { + "input": "Concept: brassinosteroid mediated signaling pathway (steroid hormone mediated signaling pathway)", + "output": "Molecular Function described as a series of molecular signals mediated by the detection of brassinosteroid." + }, + { + "input": "Concept: sbsqnt150mn inofc homeo ntak (Existing client in-office without ICD diagnosis)", + "output": "Existing client in-office without ICD diagnosis described as using homeopathic assessment methods in a comprehensive, prolonged, subsequent, 150-minute, in-office meeting to assess the health status of an existing homeopathy client to reevaluate and/or develop a homeopathic treatment plan." + }, + { + "input": "Concept: positive regulation of connective tissue growth factor biosynthesis (positive regulation of connective tissue growth factor production)", + "output": "Cell Function described as any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of connective tissue growth factor." + }, + { + "input": "Concept: PORPHYROMONAS (Anaerobic Gram-negative bacillus)", + "output": "something described as a genus of gram-negative, anaerobic, nonsporeforming, nonmotile rods or coccobacilli. Organisms in this genus had originally been classified as members of the BACTEROIDES genus but overwhelming biochemical and chemical findings indicated the need to separate them from other Bacteroides species, and hence, this new genus was created." + }, + { + "input": "Concept: Millettia Wight & Arn., 1834 (Plant)", + "output": "Millettieae described as a plant genus of the family FABACEAE. Members contain ISOFLAVONES, some of which show molluscicidal and schistosomicidal activity. Some species of Pongamia have been reclassified to this genus and some to DERRIS." + }, + { + "input": "Concept: Toothpaste, NOS (Dental Materials)", + "output": "Dental consumables described as semi-solid, usually multidose preparation consisting of a hydrophilic paste intended to be rubbed onto the teeth." + }, + { + "input": "Concept: CARDIAC STENT PLACEMENT (Therapeutic or Preventive Procedure)", + "output": "something described as a procedure performed during a percutaneous coronary intervention in which a device is deployed into the lumen of a coronary artery to expand and support the vessel wall such that the vessel remains patent and blood flow is uninhibited." + }, + { + "input": "Concept: GACI1 (Rare Non-Neoplastic Disorder)", + "output": "Rare Non-Neoplastic Disorder described as an autosomal recessive genetic disorder caused by mutations in the ENPP1 gene, encoding ectonucleotide pyrophosphatase/phosphodiesterase family member 1. The condition is characterized by calcification and narrowing of medium- and large-sized arteries, resulting in cardiovascular complications." + }, + { + "input": "Concept: RCCP1 (Papillary Renal Cell Carcinoma)", + "output": "something described as a papillary renal cell carcinoma characterized by the presence of papillae covered by small cells with scant amount of cytoplasm. The cells are arranged in a single layer on the basement membrane of the papillae." + }, + { + "input": "Concept: Grade 4 Fallopian Tube Anastomotic Leak, CTCAE (Finding)", + "output": "Fallopian Tube Anastomotic Leak, CTCAE described as life-threatening consequences; urgent operative intervention indicated" + }, + { + "input": "Concept: Renal hypoplasia/aplasia (Finding)", + "output": "Abnormal renal morphology described as absence or underdevelopment of the kidney." + }, + { + "input": "Concept: sylvestri, Pinus (Pinus )", + "output": "Oils, Volatile described as a plant species of the genus PINUS which is the source of pinosylvin. It is sometimes called Scotch pine or Scots pine, which is also a common name for other species of this genus." + }, + { + "input": "Concept: positive regulation of lipoprotein particle clearance (positive regulation of multicellular organismal process)", + "output": "regulation of lipoprotein particle clearance described as any process that increases the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." + }, + { + "input": "Concept: 14q23-q24.1 (Chromosome band)", + "output": "Cell Component described as a chromosome band present on 14q" + }, + { + "input": "Concept: 3' End Processing, RNA (Genetic Function)", + "output": "something described as the steps that generate the 3' ends of mature RNA molecules. For most mRNAs (RNA, MESSENGER), 3' end processing referred to as POLYADENYLATION includes the addition of POLY A." + }, + { + "input": "Concept: water-electrolyte imbalance (Metabolic Diseases)", + "output": "Metabolic Diseases described as disturbances in the body's WATER-ELECTROLYTE BALANCE." + }, + { + "input": "Concept: Swelling Keeps Me From Wearing What I Want to Wear (Clinical or Research Assessment Question)", + "output": "Clinical or Research Assessment Question described as a question about whether an individual's swelling keeps or kept them from wearing clothes or shoes they want or wanted to wear." + }, + { + "input": "Concept: LEGIONELLA PNEUMOPHILA SEROGROUP 4 (Legionella pneumophila)", + "output": "Legionella described as subgroup 4 of Legionella pneumophila, differentiated by its antigenicity." + }, + { + "input": "Concept: Neoplasm of Ear (Ear disorders NEC)", + "output": "Ear disorders NEC described as tumors or cancer of any part of the hearing and equilibrium system of the body (the EXTERNAL EAR, the MIDDLE EAR, and the INNER EAR)." + }, + { + "input": "Concept: Chives (Plant)", + "output": "Liliaceae described as a plant in the genus ALLIUM, similar to ONIONS." + }, + { + "input": "Concept: Direct site (Concept model object attribute)", + "output": "Concept model attribute described as this attribute represents the specific entity on which the observation is directly made, and is used when the observation is indirect, such as when a direct observation is not possible to be done on the entity in which the observable inheres." + }, + { + "input": "Concept: BIRABRESIB (Pharmacologic Substance)", + "output": "Organic Chemical described as a synthetic, small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins 2, 3 and 4 with potential antineoplastic activity. Upon administration, birabresib binds to the acetylated lysine recognition motifs on the bromodomain of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histone peptides. This disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes, including c-Myc-dependent target genes, may lead to an inhibition of tumor cell growth. Characterized by a tandem repeat of bromodomain at the N-terminus, the BET proteins BRD2, BRD3, BRD4 are transcriptional regulators that play an important role in cellular growth." + }, + { + "input": "Concept: Lymphocytes Atypical (Laboratory Procedure)", + "output": "Laboratory Procedure described as a measurement of the atypical lymphocytes in a biological specimen." + }, + { + "input": "Concept: Spring, Natural (Natural Phenomenon or Process)", + "output": "Groundwater described as water that emerges to the surface of the earth from underground." + }, + { + "input": "Concept: Grade 1 Prolapse of intestinal stoma (Finding)", + "output": "something described as asymptomatic; reducible" + }, + { + "input": "Concept: Recurrent Paget's Disease of the Breast (Recurrent Adenocarcinoma)", + "output": "Neoplastic Process described as the reemergence of Paget disease of the breast after a period of remission." + }, + { + "input": "Concept: HLA-6.0 (HLA-G gene)", + "output": "HLA-G gene described as human HLA-G wild-type allele is located in the vicinity 6p21.3 and is approximately 4 kb in length. This allele, which encodes HLA class I histocompatibility antigen, alpha chain G protein, plays a role in MHC class I-mediated immune responses." + }, + { + "input": "Concept: GTPase activating protein binding (Molecular Function)", + "output": "Protein Binding described as interacting selectively and non-covalently with a GTPase activating protein." + }, + { + "input": "Concept: High leucine levels in cerebrospinal fluid (Abnormal CSF leucine concentration)", + "output": "Finding described as abnormally increased levels of leucine in cerebrospinal fluid." + }, + { + "input": "Concept: Microbiology Susceptibility Link Identifier (Intellectual Product)", + "output": "Intellectual Product described as a sequence of characters used as a linkage between related microbiology susceptibility test identifier records." + }, + { + "input": "Concept: Sebaceous Breast Carcinoma (Sebaceous Adenocarcinoma)", + "output": "Sebaceous Adenocarcinoma described as a very rare breast adenocarcinoma with sebaceous differentiation." + }, + { + "input": "Concept: PQL1225 (PedsQL Neuromuscular Module Acute Version 3.0 Teen Report Questionnaire Question)", + "output": "PedsQL Neuromuscular Module Acute Version 3.0 Teen Report Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Acute Version 3.0 Teen Report (PedsQL Neuromuscular Module Acute Version 3.0 Teen Report) In the past 7 days, how much of a problem has this been for you: I do not have the equipment I need." + }, + { + "input": "Concept: autolysis (Biophysical Processes)", + "output": "something described as disintegration of cells by the action of their own autogenous enzymes or destruction of cells of the body by its own serum." + }, + { + "input": "Concept: Adrenal Cancer Clinical TNM Finding v7 (Adrenal Cancer TNM Finding v7)", + "output": "something described as a clinical finding about one or more characteristics of adrenal cancer, following the rules of the TNM AJCC v7 classification system. Clinical examination and radiographic imaging are required to assess the size of the primary tumor and the extent of disease, both local and distant. Biochemical studies should be performed to evaluate the functional status of the tumor." + }, + { + "input": "Concept: Security Group (Groups)", + "output": "Conceptual Entity described as a group created to indicate the access level of member individuals." + }, + { + "input": "Concept: Glutamate Carboxypeptidase II (Hydrolase)", + "output": "Carboxypeptidase described as a metallocarboxypeptidase that is predominantly expressed as a membrane-bound enzyme. It catalyzes the hydrolysis of an unsubstituted, C-terminal glutamyl residue, typically from PTEROYLPOLYGLUTAMIC ACIDS. It was formerly classified as EC 3.4.19.8." + }, + { + "input": "Concept: neuroligin 4 X-linked (Gene or Genome)", + "output": "something described as this gene may play a role in synapse development." + }, + { + "input": "Concept: Akoli (Luo language)", + "output": "Language described as a Southern Luo dialect spoken by the Acoli people in the districts of Gulu, Kitgum and Pader in northern Uganda. It is also spoken in southern Sudan in Magwi County of Eastern Equatoria state." + }, + { + "input": "Concept: Ocular Adnexal Lymphoma cM1b TNM Finding v7 (Ocular Adnexal Lymphoma Clinical Distant Metastasis TNM Finding v7)", + "output": "something described as lymphomatous involvement of the bone marrow." + }, + { + "input": "Concept: FACT-BR Questionnaire (Intellectual Product)", + "output": "something described as a 50-item instrument that assesses general physical, social, emotional and functional well-being, as well as brain tumor-specific concerns." + }, + { + "input": "Concept: Importance Score 0 (Importance Rating Likert Scale)", + "output": "Importance Rating Likert Scale described as a subjective score of 0 on a scale that ranges from 0: Not at all important to 4: Extremely important." + }, + { + "input": "Concept: early endosome to late endosome transport (Cell Function)", + "output": "something described as the directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." + }, + { + "input": "Concept: Multiple Membrane Spanning Receptor TRC8 Gene (RNF139 gene)", + "output": "RNF139 gene described as human RNF139 wild-type allele is located within 8q24 and is approximately 14 kb in length. This allele, which encodes RING finger protein 139, is involved in mediating ubiquitination. RNF139 gene dysfunction is associated with renal cell carcinoma." + }, + { + "input": "Concept: positive regulation of heart growth (Organism Function)", + "output": "regulation of heart growth described as any process that increases the rate or extent of heart growth. Heart growth is the increase in size or mass of the heart." + }, + { + "input": "Concept: Abnormality of zygomaticus major muscle (Abnormality of muscle of facial expression)", + "output": "Abnormality of muscle of facial expression described as an abnormality of a zygomaticus major muscle." + }, + { + "input": "Concept: HAQ-DI With VAS - Help From Another Person - Eating (Intellectual Product)", + "output": "something described as health Assessment Questionnaire Disability Index With Pain Visual Analog Scale - Usually need help from another person: Eating." + }, + { + "input": "Concept: Hypopharyngeal Cancer pN2a TNM Finding v7 (Hypopharyngeal Cancer pN2 TNM Finding v7)", + "output": "Hypopharyngeal Cancer Pathologic Regional Lymph Nodes TNM Finding v6 described as hypopharyngeal cancer with metastasis to a single ipsilateral lymph node, more than 3 cm, but not more than 6 cm in greatest dimension." + }, + { + "input": "Concept: SYP Staining Method (Laboratory Procedure)", + "output": "something described as this is an immunohistochemical technique utilizing antibody to synaptophysin, an integral membrane glycoprotein present in presynaptic vesicles in neurons. The antibody labels neuroendocrine cells and neurons of the brain, spinal cord and retina. Used to detect neuroendocrine neoplasms including neuroblastomas, ganglioneuroblastomas, ganglioneuromas, pheochromocytomas, chromaffin, and non-chromaffin paragangliomas." + }, + { + "input": "Concept: Forestry (Industry)", + "output": "something described as the science of developing, caring for, or cultivating forests." + }, + { + "input": "Concept: Lung Development (Histogenic Process)", + "output": "something described as for the lung, the act or process of natural progression in physical and physiological maturation from a previous, lower, or embryonic stage to a later, more complex, or adult stage." + }, + { + "input": "Concept: 5'-3' Exoribonuclease 1 (Ribonucleases)", + "output": "something described as 5'-3' exoribonuclease 1 (1706 aa, ~194 kDa) is encoded by the human XRN1 gene. This protein plays a role in ribonucleotide metabolism." + }, + { + "input": "Concept: DIP3 (Structure of distal interphalangeal joint)", + "output": "Structure of distal interphalangeal joint described as a ginglymoid (hinge) synovial joint within the third digit of the hand or foot connecting the middle and distal phalanges." + }, + { + "input": "Concept: Rituals (Behavior)", + "output": "Action described as an action or series of actions that is repeated, often in a religious or social setting. In medicine, it may describe a repeated action (such as hand washing) done to relieve feelings of fear, dread, and uneasiness in people who have an obsessive-compulsive disorder." + }, + { + "input": "Concept: Sequencing, Deep (Molecular Biology Research Technique)", + "output": "something described as techniques of nucleotide sequence analysis that increase the scale of operations enabling an increase in the depth of coverage (number of copies) to which each polynucleotide is sequenced." + }, + { + "input": "Concept: himalaya proselect, abana 60 (Clinical Drug)", + "output": "Nutraceuticals described as himalaya ProSelect(TM) Abana 60, 720 mg tablets. UPC Code 605069101011." + }, + { + "input": "Concept: vascular endothelial growth factor signalling pathway (Molecular Function)", + "output": "something described as a series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription." + }, + { + "input": "Concept: Decreased circulating heparan sulphate level (Abnormal circulating heparan sulfate level)", + "output": "Abnormal circulating heparan sulfate level described as an abnormal decrease in the concentration of heparan sulfate in the blood." + }, + { + "input": "Concept: Procedure Kit/Trays, Anesthesia, Spinal (Procedure Kit/Trays, Anesthesia)", + "output": "Medical Device described as prepackaged collections of the devices and supplies (either custom or standard) needed for providing local anesthesia into the subarachnoid space around the spinal cord. Items in these kits usually include an anesthetic administration syringe, a Luer tip with needle, a syringe with pre-attached needle, anesthetics (e.g., lidocaine), a povidone iodine packet, prep cups, swab sticks, gauze pads, towel(s), a fenestrated drape, a sharps stick pad, and adhesive bandages. The kits are frequently supplied in supporting trays (i.e., procedure trays) consisting of a flat-bottomed receptacle with a border around the periphery supporting all the instruments and supplies needed for the procedure; the trays are usually covered or wrapped. Spinal anesthesia kits and trays are usually intended for use in a nerve block limited to the regions below the lower abdomen during diagnostic and/or therapeutic procedures." + }, + { + "input": "Concept: Is modification of (Concept model object attribute)", + "output": "something described as this attribute indicates that the concept is a structural modification of another concept." + }, + { + "input": "Concept: Endoscopy Procedures on the Larynx (Laryngoscopy)", + "output": "Procedure categorized by device involved described as endoscopic examination of the larynx." + }, + { + "input": "Concept: Arthropod Borne Encephalitis (Arthropod-borne infectious disease)", + "output": "Arbovirus encephalitis described as infections of the brain caused by arthropod-borne viruses primarily from the families togaviridae, flaviviridae, bunyaviridae, reoviridae and rhabdoviridae; life cycles of these viruses are characterized by zoonoses, with birds and lower mammals serving as intermediate hosts; the virus is transmitted to humans by the bite of mosquitoes or ticks; clinical manifestations include fever, headache, alterations of mentation, focal neurologic deficits, and coma." + }, + { + "input": "Concept: Phylogenetic Analyse (Research Activity)", + "output": "Research Techniques described as phylogenetic analysis is the study of evolutionary relationships among the many different kinds of life on earth, both living (extant) and dead (extinct). It includes creating evolutionary trees using computer programs." + }, + { + "input": "Concept: MGMT Promoter Methylation Testing Was Performed (Finding)", + "output": "Finding described as an indication that MGMT promoter methylation analysis was performed during the study." + }, + { + "input": "Concept: Client satisfaction: safety (Finding)", + "output": "something described as extent of positive perception of procedures, information, and nursing care to prevent harm or injury" + }, + { + "input": "Concept: Eyelid Carcinoma TNM Finding v8 (Finding)", + "output": "Ophthalmic Sites Cancer TNM Finding v8 described as a finding about one or more characteristics of eyelid carcinoma, following the rules of the TNM AJCC v8 classification system. This classification system applies to all primary carcinomas of the eyelid, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), sebaceous carcinoma, and other rare carcinomas, such as all varieties of sweat gland carcinoma (e.g., eccrine carcinoma). It does not apply to carcinomas of the head and neck with direct extension to eyelid (are staged according to the cutaneous squamous cell carcinomas of the head and neck), Merkel cell carcinomas of the eyelid (are staged according to the classification for Merkel cell carcinomas), and melanomas of the eyelid (are staged according to the classification for melanomas of the skin)." + }, + { + "input": "Concept: Uterine Anastomotic Leak, CTCAE (Injury, Poisoning and Procedural Complications, CTCAE)", + "output": "Injury, Poisoning and Procedural Complications, CTCAE described as a finding of leakage due to breakdown of a uterine anastomosis (surgical connection of two separate anatomic structures)." + }, + { + "input": "Concept: Mast Cell Count (Laboratory Procedure)", + "output": "something described as a measurement of the mast cells in a biological specimen." + }, + { + "input": "Concept: E157E/Q (Finding)", + "output": "something described as HIV mutation in the integrase (IN) coding region" + }, + { + "input": "Concept: Relapsed Urinary Bladder Cancer (Malignant neoplasm of urinary bladder)", + "output": "Malignant neoplasm of bladder recurrent described as the reemergence of bladder carcinoma after a period of remission." + }, + { + "input": "Concept: deficiency; diet (Nutrition function)", + "output": "Malnutrition described as disorder of nutrition due to unbalanced or insufficient diet or to defective assimilation or utilization of nutrients." + }, + { + "input": "Concept: UHDRS 1999 Version - UDHR1-Examiner Believe Subject Confused (UHDRS 1999 Version Clinical Classification Question)", + "output": "Intellectual Product described as unified Huntington's Disease Rating Scale 1999 Version (UHDRS 1999 Version) Confusion is defined as intermittent or persistent disorganized thinking, perceptual disturbances or disorientation to time, place, or person. Does the examiner believe the subject is confused?" + }, + { + "input": "Concept: CSS0720A (C-SSRS Children's Baseline/Screening Questionnaire Question)", + "output": "something described as columbia-Suicide Severity Rating Scale Children's Baseline/Screening - Initial/first attempt date." + }, + { + "input": "Concept: DHEA mustard (Nitrogen Mustard Antineoplastic Compounds)", + "output": "Organic Chemical described as a steroidal alkylating agent with potential antineoplastic activity. Alkylating agents exert cytotoxic and, in some cases, chemotherapeutic effects by transferring alkyl groups to DNA, thereby damaging DNA and interfering with DNA replication and cell division. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2707\" active clinical trials using this agent." + }, + { + "input": "Concept: crohns's disease (Immune and associated conditions NEC)", + "output": "Gastrointestinal system described as a condition in which the gastrointestinal tract is inflamed over a long period of time. Regional enteritis usually affects the small intestine and colon. Symptoms include fever, diarrhea, stomach cramps, vomiting, and weight loss. Regional enteritis increases the risk of colorectal cancer and small intestine cancer. It is a type of inflammatory bowel disease (IBD)." + }, + { + "input": "Concept: ICE-V (Therapeutic or Preventive Procedure)", + "output": "Therapeutic or Preventive Procedure described as a chemotherapy regimen consisting of ifosfamide, carboplatin, etoposide, and vincristine that may be used in the treatment of small-cell lung cancer (SCLC)." + }, + { + "input": "Concept: physical properties (Physical Sciences)", + "output": "Property or Attribute described as a natural phenomenon involving the physics of matter and energy." + }, + { + "input": "Concept: Upper Gastrointestinal Tract (DIGESTIVE SYSTEM: GENERAL TERMS)", + "output": "DIGESTIVE SYSTEM: GENERAL TERMS described as esophagus, stomach, and duodenum" + }, + { + "input": "Concept: My pet has diarrhea (Intellectual Product)", + "output": "Clinical or Research Assessment Question described as a question about whether an individual's pet has diarrhea." + }, + { + "input": "Concept: School Maladjustment (Research or Clinical Assessment Tool)", + "output": "something described as a rating scale included in the Behavior Assessment System for Children, College Version that provides an indication of how the subject is responding to the academic demands of college." + }, + { + "input": "Concept: How Much Does Illness and/or Treatment Interfere with Community and Civic Involvement (Intellectual Product)", + "output": "Clinical or Research Assessment Question described as a question about how much an individual's illness and/or treatment interferes with their community and civic involvement." + }, + { + "input": "Concept: SULICRINAT (Organic Chemical)", + "output": "something described as an ethacrynic derivative with diuretic activity." + }, + { + "input": "Concept: Chronic pericementitis (Chronic Periodontitis)", + "output": "Disease or Syndrome described as chronic inflammation and loss of PERIODONTIUM that is associated with the amount of DENTAL PLAQUE or DENTAL CALCULUS present. Chronic periodontitis occurs mostly in adults and was called adult periodontitis, but this disease can appear in young people." + }, + { + "input": "Concept: D52 (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as tumor protein D52 (224 aa, ~24 kDa) is encoded by the human TPD52 gene. This protein is involved in morphogenesis." + }, + { + "input": "Concept: Calipers, Skinfold, Electronic (Personal care and protection device)", + "output": "something described as skinfold calipers designed to assess body fat in subcutaneous adipose tissue by measuring the skinfold thickness and processing the data electronically. Measurement of the thickness of folds of skin gathered at various areas of the body is displayed on the device. These instruments are typically electrically powered (usually with batteries), handheld, pistol-like metallic and/or rigid plastic calipers with curved working ends that apply even pressure to the skinfold. Electronic skinfold calipers help to perform fast and repetitive measurements on the posterior aspect of the upper arm, thighs, or back or over the lower ribs; the instruments typically show the results as percent body fat (e.g., using an standard algorithm such as the Jackson-Pollack formula) in a digital display." + }, + { + "input": "Concept: My voice problem upsets me (Clinical or Research Assessment Question)", + "output": "something described as a question about how frequently an individual's voice problem upsets them." + }, + { + "input": "Concept: Peripheral neuropathy, myopathy, hoarseness, deafness syndrome (Chronic disease of ear)", + "output": "Peripheral Nervous System Diseases described as a rare syndromic genetic deafness with characteristics of a combination of muscle weakness, chronic neuropathic and myopathic features, hoarseness and sensorineural hearing loss. A wide range of disease onset and severity has been reported even within the same family. There is evidence the disease is caused by heterozygous mutation in the MYH14 gene on chromosome 19q13." + }, + { + "input": "Concept: C-SSRS Already Enrolled Subjects - Describe Most Severe Ideation (C-SSRS Already Enrolled Subjects Questionnaire Question)", + "output": "something described as columbia-Suicide Severity Rating Scale Already Enrolled Subjects - Description of most severe ideation. (Prior to Study Entry)." + }, + { + "input": "Concept: Questioning (Thesaurus of Psychological Index Terms)", + "output": "Sexual Orientation described as used to describe an individual who is unsure of their sexual orientation." + }, + { + "input": "Concept: Grade 1 Vaginal stricture (Vaginal Stricture, CTCAE)", + "output": "something described as asymptomatic; mild vaginal shortening or narrowing" + }, + { + "input": "Concept: fenestrated-endothelial linked structure protein; PV-1 protein (Ligand Binding Protein Gene)", + "output": "Ligand Binding Protein Gene described as this gene may be involved in caveolae structure." + }, + { + "input": "Concept: Planned Criterion Group Option Relationship Comment (Intellectual Product)", + "output": "Published Comment described as additional description of the criterion group option relationship." + }, + { + "input": "Concept: rostral part of the lateral subnucleus (Body Part, Organ, or Organ Component)", + "output": "something described as one of four parts of the lateral subnucleus of the interpeduncular nucleus of the rat ( Swanson-2004 )." + }, + { + "input": "Concept: P1H12 protein, human (Cell Adhesion Molecules)", + "output": "something described as cell surface glycoprotein MUC18 (646 aa, ~72 kDa) is encoded by the human MCAM gene. This protein is involved in vascular endothelial cell adhesion." + }, + { + "input": "Concept: Anterior mediastinal lymph node (Structure of lymph node of thorax)", + "output": "Mediastinal lymph node group described as a lymph node located in the superior mediastinum that collects lymph from the thymus, the pericardium, and the right side of the heart." + }, + { + "input": "Concept: ascus lipid particle (Lipid droplet)", + "output": "Cell Component described as any particle of coalesced lipids in an ascus or ascospore. May include associated proteins." + }, + { + "input": "Concept: ERV (Retroviridae)", + "output": "something described as genetic elements propagated primarily through the germline, with a proviral structure, i.e. the chromosomally-integrated form of retroviruses and regulated by cellular processes. Could be involved in development and serve as progenitors to pathogenic retroviruses. Classified as ecotropic or xenotropic. Ecotropic viruses can be transmitted to cells of the same species and can produce malignancies. Xenotropic viruses cannot infect cells from their host species but are infectious in heterologous species. Cycles of transcription and reverse transcription make the elements mobile and mutagenic." + }, + { + "input": "Concept: SNX2112 (Organic Chemical)", + "output": "Organic Chemical described as a human heat-shock protein 90 (Hsp90) inhibitor, with potential antineoplastic activity. SNX-2112 selectively accumulates in tumors compared to normal tissues, and binds to the N-terminal adenosine triphosphate binding site of Hsp90, inhibiting its activity. This results in the proteasomal degradation of oncogenic client proteins, which prevents signaling through these client proteins, induces apoptosis and inhibits tumor cell proliferation. Hsp90 is a 90kDa molecular chaperone that plays a key role in the conformational maturation and stabilization of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation, proliferation, apoptosis, and survival; Hsp90 is overexpressed by certain types of tumor cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C91068\" active clinical trials using this agent." + }, + { + "input": "Concept: Chignon from vacuum extraction (chignon)", + "output": "Birth Complication described as a cone-shaped swelling on the head produced by applying suction during vacuum-assisted delivery. It is temporary and usually resolves without treatment." + }, + { + "input": "Concept: Cytidine Monophosphate N-Acetylneuraminic Acid (Cytidine Monophosphate)", + "output": "Cytidine Monophosphate described as a nucleoside monophosphate sugar which donates N-acetylneuraminic acid to the terminal sugar of a ganglioside or glycoprotein." + }, + { + "input": "Concept: When you talked on a phone, how hard was it to understand what the other person was saying (Clinical or Research Assessment Question)", + "output": "something described as a question about how hard it was for an individual to understand what the other person was saying while talking on a telephone." + }, + { + "input": "Concept: Gene Targeting (Molecular Genetic Technique)", + "output": "genetic manipulation described as the integration of exogenous DNA into the genome of an organism at sites where its expression can be suitably controlled. This integration occurs as a result of homologous recombination." + }, + { + "input": "Concept: GLO-GM2-LE-MUC1-sTN-TF-TN-KLH (Cancer Vaccines)", + "output": "something described as a heptavalent vaccine consisting of the tumor-associated carbohydrate antigens globohexaosylceramide (globo-H), GM2, Lewis-y, MUC1-32(aa), sTn(c), TF(c), and Tn(c) conjugated with keyhole limpet hemocyanin (KLH), an immunomodulator. This vaccine may induce the production of IgG and IgM antibodies and an antibody-dependent cell-mediated cytotoxicity (ADCC) against tumors expressing these antigens." + }, + { + "input": "Concept: Post-vaccination rotavirus infection (Disease or Syndrome)", + "output": "Infection following live vaccination described as infection with live attenuated rotavirus vaccine following vaccination." + }, + { + "input": "Concept: School Nursing (School Health Services)", + "output": "Specialties, Nursing described as nurses in this specialty are dedicated to promoting the health and well-being of children of all ages in an academic environment" + }, + { + "input": "Concept: Gastric fistula (Gastrointestinal and hepatobiliary procedural complications)", + "output": "Lesion of stomach described as an abnormal communication between the stomach and another organ or anatomic site." + }, + { + "input": "Concept: galacturonokinase activity (kinase activity)", + "output": "something described as catalysis of the reaction: alpha-D-galacturonate + ATP = 1-phospho-alpha-D-galacturonate + ADP + 2 H(+)." + }, + { + "input": "Concept: 6a-hydroxymaackiain-3-O-methyltransferase activity (methyltransferase activity)", + "output": "Molecular Function described as catalysis of the reaction: (+)-6a-hydroxymaackiain + S-adenosyl-L-methionine <=> H+ + (+)-pisatin + S-adenosyl-L-homocysteine." + }, + { + "input": "Concept: Cancer/Testis Antigen 91 Positive (Laboratory or Test Result)", + "output": "Positive Laboratory Test Result described as an indication that ROPN1 expression has been detected in a sample." + }, + { + "input": "Concept: READER, PRISM, OPHTHALMIC (Medical Device)", + "output": "Medical Device described as an ophthalmic prism reader is a device intended for use by a patient who is in a supine position to change the angle of print to aid reading." + }, + { + "input": "Concept: Concentrate for Solution for Injection/Infusion Dosage Form (Concentrated Solution Dosage Form)", + "output": "Biomedical or Dental Material described as sterile liquid preparation intended to be diluted in the specified liquid to obtain a solution for injection/infusion." + }, + { + "input": "Concept: Gel (Basic Dosage Form Category)", + "output": "Basic Dosage Form Category described as a type of semi-solid pharmaceutical dose form consisting of a colloidal dispersion of a liquid in a solid; lipophilic gels (oleogels) usually consist of liquid paraffin with polyethylene or fatty oils gelled with colloidal silica or aluminium or zinc soaps; hydrophilic gels (hydrogels) usually consists of water, glycerol or propylene glycol gelled with suitable gelling agents such as poloxamers, starch, cellulose derivatives, carbomers and magnesium-aluminium silicates." + }, + { + "input": "Concept: Sacral Torsion (Finding)", + "output": "Somatic dysfunction of sacral spine described as 1. A physiologic function occurring in the sacrum during ambulation and forward bending. 2. A sacral somatic dysfunction around an oblique axis in which a torque occurs between the sacrum and innominates. The L5 vertebra rotates in the opposite direction of the sacrum. 3. If the L5 does not rotate opposite to the sacrum, L5 is termed maladapted.4. Other terms for this maladaption include: rotations about an oblique axis, anterior or posterior sacrum and a torsion with a non-compensated L5 (Archaic use)." + }, + { + "input": "Concept: Red Star Thistles (Asteraceae)", + "output": "Asteraceae described as a plant genus of the family ASTERACEAE. Members contain 5-methyl-8-hydroxycoumarin. The common name of centaury is more often used for CENTAURIUM" + }, + { + "input": "Concept: positive regulation of eosinophil extravasation (Cell Function)", + "output": "positive regulation of cellular extravasation described as any process that activates or increases the frequency, rate or extent of eosinophil extravasation." + }, + { + "input": "Concept: Eosinophilia, NOS (Eosinophilia)", + "output": "Raised hematology finding described as disordered formation of eosinophils or an abnormal accumulation or deficiency of these cells." + }, + { + "input": "Concept: desmoid (Benign neoplasm of soft tissue)", + "output": "Neoplastic disease described as a childhood counterpart of abdominal or extra-abdominal desmoid tumors, characterized by firm subcutaneous nodules that grow rapidly in any part of the body but do not metastasize. The adult form of abdominal fibromatosis is FIBROMATOSIS, ABDOMINAL." + }, + { + "input": "Concept: SYSTEM, TEST, TUMOR MARKER, MONITORING, BLADDER (Medical Device)", + "output": "Medical Device described as a tumor-associated antigen immunological test system is a device that consists of reagents used to qualitatively or quantitatively measure, by immunochemical techniques, tumor-associated antigens in serum, plasma, urine, or other body fluids." + }, + { + "input": "Concept: Have Acid Indigestion or Heartburn (Intellectual Product)", + "output": "Intellectual Product described as a question about whether an individual has or had acid indigestion or heartburn." + }, + { + "input": "Concept: Auditory projection area structure (Sensorimotor Cortex)", + "output": "auditory nerve system described as area of the temporal lobe concerned with hearing." + }, + { + "input": "Concept: Rhabdomyocyte (Cells)", + "output": "Differentiated muscle cell described as large, multinucleate single cells, either cylindrical or prismatic in shape, that form the basic unit of SKELETAL MUSCLE. They consist of MYOFIBRILS enclosed within and attached to the SARCOLEMMA. They are derived from the fusion of skeletal myoblasts (MYOBLASTS, SKELETAL) into a syncytium, followed by differentiation." + }, + { + "input": "Concept: G PROTEIN-COUPLED RECEPTOR 101 (Gene or Genome)", + "output": "something described as this gene may play a role in receptor signaling." + }, + { + "input": "Concept: Perque(TM) Perkies Honey Malt each 270 tablets (Clinical Drug)", + "output": "Clinical Drug described as perque(TM) Perkies Honey Malt each 270 tablets. UPC Code 79176003080." + }, + { + "input": "Concept: ARCANOBACTERIUM HAEMOLYTICUM (Bacterium)", + "output": "Corynebacterium described as a species of facultatively anaerobic, Gram positive, rod shaped bacteria assigned to the phylum Actinobacteria. This bacteria is catalase negative, hemolytic on human blood agar plates and grows best in culture with added carbon dioxide and blood. A. haemolyticum is found on human skin and mucus membranes of the upper respiratory tract, and is associated with pharyngitis and skin and tissue infections." + }, + { + "input": "Concept: lateral parietal association cortex (Body Part, Organ, or Organ Component)", + "output": "Body Part, Organ, or Organ Component described as a cortical area on the dorsal surface of the cerebral cortex in the mouse ( Paxinos-2001 )." + }, + { + "input": "Concept: Infection, Actinobacillus (Actinobacillus Infections)", + "output": "Disease due to Gram-negative bacillus described as infections with bacteria of the genus ACTINOBACILLUS." + }, + { + "input": "Concept: Wnt-activated signaling pathway, planar cell polarity pathway involved in midbrain DA neurogenesis (Molecular Function)", + "output": "something described as any Wnt signaling pathway, planar cell polarity pathway that is involved in midbrain dopaminergic neuron differentiation." + }, + { + "input": "Concept: Osteochondritis (Osteochondritis)", + "output": "Osteochondritis described as inflammation of a bone and its overlaying CARTILAGE." + }, + { + "input": "Concept: Menopausal Symptoms Attenuation (Therapeutic or Preventive Procedure)", + "output": "something described as therapy to reduce the effects of menopausal symptoms. May also be necessary in order to counteract the effect of various chemotherapy treatments." + }, + { + "input": "Concept: Triticum, NOS (Triticinae)", + "output": "Plant described as a plant genus of the family POACEAE that is the source of EDIBLE GRAIN. A hybrid with rye (SECALE CEREALE) is called TRITICALE. The seed is ground into FLOUR and used to make BREAD, and is the source of WHEAT GERM AGGLUTININS." + }, + { + "input": "Concept: Gum Arabic Solution (Pharmacologic Substance)", + "output": "Protective Agents described as a solution containing the polymer gum acacia (gum Arabic), exuded from various Acacia trees, especially from Acacia senegal (Leguminosae), with potential protective and anti-mucositis activities. Upon administration of the gum Arabic solution in the oral cavity, the polymer forms a protective barrier over the oral mucosa, which may prevent inflammation of the mucosal membranes and may decrease chemotherapy- and/or radiation-induced oral mucositis." + }, + { + "input": "Concept: RELN wt Allele (Gene or Genome)", + "output": "Gene or Genome described as human RELN wild-type allele is located in the vicinity of 7q22 and is approximately 518 kb in length. This allele, which encodes reelin protein, plays a role in extracellular matrix proteolysis, signal transduction and neuronal development. Mutation of the gene is associated with lissencephaly type 2." + }, + { + "input": "Concept: Shoe Cover Removers, Automated (Manufactured Object)", + "output": "something described as devices designed for automated removal (i.e., doffing) of disposable shoe covers. These devices typically consist of a machine that automatically extracts (e.g., by suctioning) without manual touching the shoe covers; the device is attached to a container for temporary storage of the disposed covers. Shoe cover automated removers are used mainly in hospital or other health care facility areas (e.g., treatment, clean and operating rooms; clinical laboratories) where a high volume of covers should be quickly and easily removed. The removers are intended to take-off shoe covers for hygienic purposes and/or personal protection. They are usually available as stand-alone units or units to be placed attached to a wall." + }, + { + "input": "Concept: Maculae, Acoustic (Body Part, Organ, or Organ Component)", + "output": "Saccule and Utricle described as the sensory areas on the vertical wall of the saccule and in the floor of the utricle. The hair cells in the maculae are innervated by fibers of the VESTIBULAR NERVE." + }, + { + "input": "Concept: Boder syndrome (Multiple system malformation syndrome)", + "output": "Deglutition Disorders described as odontoma-dysphagia syndrome is a malformation syndrome, with characteristics of odontomas and severe dysphagia. Less than ten cases have been reported so far. Three of the reported patients manifested multiple odontomas. Occasionally, cardiac, renal and hepatic involvement has been described. In several cases, autosomal dominant inheritance has been suspected. Currently, there are no genes associated with this condition." + }, + { + "input": "Concept: unsaturated monocarboxylic acid metabolism (Molecular Function)", + "output": "Molecular Function described as the chemical reactions and pathways involving unsaturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and one or more unsaturated C-C bonds." + }, + { + "input": "Concept: squamous cell carcinoma of the lip and oral cavity, metastatic (stage IV lip and oral cavity cancer)", + "output": "Stage IV Lip and Oral Cavity Cancer AJCC v6 and v7 described as stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0);. IVB (Any T, N3, M0); (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a (lip): Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i.e., chin or nose. T4a (oral cavity): Tumor invades adjacent structures (e.g., through cortical bone, into deep [extrinsic] muscles of tongue, maxillary sinus, skin of face). T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N2a: Metastasis in a single ipsilateral lymph node more than 3 cm but not more than 6 cm in dimension. N2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension. N2c: Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M1: Distant metastasis." + }, + { + "input": "Concept: ER and/or PR Positive (Positive Laboratory Test Result)", + "output": "something described as a finding indicating that the neoplastic cells in a tissue sample test positive for estrogen and/or progesterone receptors." + }, + { + "input": "Concept: Mole per Liter (Potency Unit)", + "output": "Quantitative Concept described as a unit of concentration (molarity unit) equal to one mole of solute in one liter of solution." + }, + { + "input": "Concept: LEGIONELLA LONGBEACHAE (Legionella species)", + "output": "Legionella described as any bacterial organism that can be assigned to the species Legionella longbeachae." + }, + { + "input": "Concept: Tennis, squash, or racquetball (Clinical or Research Assessment Question)", + "output": "Clinical or Research Assessment Question described as a question about time spent playing tennis, squash or racquetball." + }, + { + "input": "Concept: wooly hair (Hair)", + "output": "Disorder of hair shaft described as the term woolly hair refers to an abnormal variant of hair that is fine, with tightly coiled curls, and often hypopigmented. Optical microscopy may reveal the presence of tight spirals and a clear diameter reduction as compared with normal hair. Electron microscopy may show flat, oval hair shafts with reduced transversal diameter." + }, + { + "input": "Concept: Anterior Gradient 2 Gene (Genes, Regulator)", + "output": "Gene or Genome described as this gene is involved in differentiation. It also plays a putative role in tumor metastasis." + }, + { + "input": "Concept: positive regulation of transcription elongation from RNA polymerase II promoter (regulation of transcription elongation from RNA polymerase II promoter)", + "output": "something described as any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." + }, + { + "input": "Concept: Thyroid dysfunction (Classification)", + "output": "something described as thyroid dysfunction can present as hypo- or hyperactive thyroidal function. Hypothyroidism is thyroid hormone deficiency. Primary hypothyroidism is due to thyroid disease; TSH is increased. Most common cause is autoimmune. Other common causes are post-therapeutic, occurring after radioactive iodine therapy, surgery, radiation, or lithium therapy. Secondary hypothyroidism occurs when hypothalamus produces insufficient TRH or pituitary produces insufficient TSH. Signs and symptoms of hypothyroidism include: cold intolerance, constipation, personality changes, dementia or frank psychosis, hoarse voice, facial puffiness, coarse hair and skin, fluid retention, decreased metabolism, paresthesias, decreased libido, menstrual irregularities, bradycardia, pericardial effusions. Hyperthyroidism is excessive production of iodinated thyroid hormones, T3 and T4. Graves' disease (toxic diffuse goiter) is most common cause and is characterized by hyperthyroidism, goiter, exophthalmos, pretibial myxedema. Inflammatory thyroid disease (thyroiditis) includes subacute granulomatous thyroiditis, Hashimoto's thyroiditis, and silent lymphocytic thyroiditis. Drug-induced hyperthyroidism can result from lithium or interferon-alpha. Signs and symptoms of hyperthyroidism include: hyperactivity, increased sweating, increased appetite, weight loss, insomnia, weakness, frequent bowel movements, hypomenorrhea, tremor; tachycardia, atrial fibrillation. Eye signs include stare and eyelid retraction. Infiltrative ophthalmopathy is specific to Graves' disease. Thyroid storm is life-threatening emergency; patients may present with fever, psychosis, coma, cardiovascular collapse." + }, + { + "input": "Concept: Onion (Liliaceae)", + "output": "Plant described as plant that provides onions." + }, + { + "input": "Concept: FAMS01-I Urinate More Frequently (FAMS Questionnaire Question)", + "output": "FAMS Questionnaire Question described as functional Assessment of Multiple Sclerosis (FAMS) Additional Concerns: I urinate more frequently than usual." + }, + { + "input": "Concept: Intrapartum Process (Period)", + "output": "Organism Function described as the process that occurs during labor and delivery." + }, + { + "input": "Concept: CD90 (Gene or Genome)", + "output": "THY1 gene described as human THY1 wild-type allele is located within 11q22.3-q23 and is approximately 6 kb in length. This allele, which encodes Thy-1 membrane glycoprotein, may play a role in the regulation of synaptogenesis." + }, + { + "input": "Concept: immunoglobulin superfamily, DCC subclass, member 2 (Gene or Genome)", + "output": "Membrane Protein Gene described as this gene plays a role in neural differentiation and cell cycle regulation." + }, + { + "input": "Concept: ACGC01-Clinical Impression of Change (Intellectual Product)", + "output": "something described as alzheimer's Disease Cooperative Study-Clinical Global Impression of Change (ADCS-CGIC) Clinical impression of change from baseline." + }, + { + "input": "Concept: IRF5:IRF5 complex (interferon regulatory factor complex)", + "output": "something described as an interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 5." + }, + { + "input": "Concept: Decreased circulating free T3 (Finding)", + "output": "Finding described as a reduced concentration of free 3,3',5-triiodo-L-thyronine in the blood circulation. []" + }, + { + "input": "Concept: Hyperextensibility of the knee (Abnormality of the knee)", + "output": "something described as the ability of the knee joint to extend beyond its normal range of motion (the lower leg is moved beyond a straight position with respect to the thigh)." + }, + { + "input": "Concept: High-performance Liquid Chromatography-UV (Laboratory Procedure)", + "output": "Laboratory Procedure described as an analytical technique where high performance liquid chromatography with an ultraviolet light detector is used to separate, identify, and quantify substances in a sample." + }, + { + "input": "Concept: Ossicular prosthesis, total (Ear, nose and throat device)", + "output": "something described as a total ossicular replacement prosthesis is a device intended to be implanted for the total functional reconstruction of the ossicular chain and facilitates the conduction of sound waves from the tympanic membrance to the inner ear. The device is made of materials such as polytetrafluoroethylene, polytetrafluoroethylene with vitreous carbon fibers composite, porous polyethylene, or from a combination of these materials." + }, + { + "input": "Concept: IDSR109 (IDS-SR Questionnaire Question)", + "output": "something described as inventory of Depressive Symptomatology - Self-Report - Please circle the one response to each item that best describes you for the past seven days: Mood in relation to the time of day." + }, + { + "input": "Concept: CDC7 Kinase Inhibitor NMS-1116354 (Serine/Threonine Kinase Inhibitor)", + "output": "Pharmacologic Substance described as an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. CDC7 kinase inhibitor NMS-1116354 binds to and inhibits the activity of CDC7, which may result in the inhibition of DNA replication and mitosis, the induction of tumor cell apoptosis, and the inhibition of tumor cell proliferation in CDC7-overexpressing tumor cells. The serine-threonine kinase CDC7 initiates DNA replication by phosphorylating MCM2 (minichromosome maintenance complex component 2) at Ser40 and Ser53." + }, + { + "input": "Concept: Recurrent Desmoid Tumor (Recurrent tumor)", + "output": "Fibromatosis, Aggressive described as desmoid-type fibromatosis that has recurred after a period of remission." + }, + { + "input": "Concept: skin pustule (Skin lesion)", + "output": "Integumentary System Signs and Symptoms described as a small circumscribed and elevated skin lesion filled with purulent material." + }, + { + "input": "Concept: Gestational Trophoblastic Tumor pT2 TNM Finding v7 (Finding)", + "output": "Finding described as gestational trophoblastic tumor extending to other genital structures (ovary, tube, vagina, broad ligaments) by metastasis or direct extension." + }, + { + "input": "Concept: sojae/dan dou chi (Plant)", + "output": "something described as dan dou chi" + }, + { + "input": "Concept: mitochondrial prohibitin complex location (inner mitochondrial membrane protein complex)", + "output": "Cell Component described as a complex composed of two proteins, prohibitin 1 and prohibitin 2 (PHB1/PHB-1 and PHB2/PHB-2) that is highly conserved amongst eukaryotes and associated with the inner mitochondrial membrane. The mitochondrial prohibitin complex is a macromolecular supercomplex composed of repeating heterodimeric subunits of PHB1 and PHB2. The mitochondrial prohibitin complex plays a role in a number of biological processes, including mitochondrial biogenesis and function, development, replicative senescence, and cell death." + }, + { + "input": "Concept: Advanced Round Cell Liposarcoma (Metastatic Round Cell Liposarcoma)", + "output": "something described as a round cell liposarcoma that has spread extensively to other anatomic sites or is no longer responding to treatment." + }, + { + "input": "Concept: Haemophilus parainfluenzae, Penicillinase Negative (Bacterium)", + "output": "something described as any bacterial organism that can be assigned to the species Haemophilus parainfluenzae and is penicillinase negative." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, GRHPR (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)", + "output": "Medical Device described as molecular assay reagents intended to identify mutations in the glyoxylate and hydroxypyruvate reductase (GRHPR) gene, located at chromosome 9p13.2, which encodes the protein glyoxylate reductase/hydroxypyruvate reductase. Genetic variants at this locus have been associated with primary hyperoxaluria type II." + }, + { + "input": "Concept: Powder and Solution for Suspension for Injection (Biomedical or Dental Material)", + "output": "Biomedical or Dental Material described as sterile powder (including freeze-dried powder) and sterile solution, both of which contain active substance(s), intended for the preparation of a suspension for injection by dispersing the powder in the solution." + }, + { + "input": "Concept: Urethral Cancer Clinical TNM Finding v7 (Urethral Cancer TNM Finding v7)", + "output": "Urethral Cancer TNM Finding v7 described as a clinical finding about one or more characteristics of urethral cancer, following the rules of the TNM AJCC v7 classification system." + }, + { + "input": "Concept: Progesterone-Binding Globulin (Proteins)", + "output": "Serum, Urine and Miscellaneous Proteins described as a glycoprotein migrating as alpha 1-globulin, molecular weight 70,000 to 120,000. The protein, which is present in increased amounts in the plasma during pregnancy, binds mainly progesterone, with other steroids including testosterone competing weakly." + }, + { + "input": "Concept: GPA-TriMAR-T-cells (Cell)", + "output": "therapeutic autologous lymphocytes described as a preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector encoding a tri-functional chimeric antigen receptor (TriCAR) comprised of an extracellular domain consisting of an antigen binding domain specific to glycoprotein 100 (gp100) peptides 209-217 complexed with human leucocyte antigen A2 (HLA-A2), interleukin 15 (IL-15) and programmed cell death 1 (PD1; PDCD1; CD279; programmed death-1), which are linked by a transmembrane domain to the intracellular signaling domains of 4-1BB (CD137) and the zeta chain of the TCR/CD3 complex (TCRzeta; CD247; CD3zeta), with potential antineoplastic activity. Upon administration, the autologous anti-gp100CAR-CD3zeta-4-1BB-IL-15-PD1-expressing tri-functional T-lymphocytes selectively bind to gp100 peptides presented by HLA-A2. Upon binding to the gp100-HLA complex, the T-cells release cytokines and induce selective toxicity in gp100-expressing tumor cells. IL-15 is a pro-survival cytokine that promotes T-cell persistence and potentiates the immune response against tumor cells. The PD1 moiety binds to programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274) on tumor cells, reversing T-cell inactivation caused by endogenous PD1/PD-L1 signaling and enhancing the cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response against PD-L1-expressing tumor cells." + }, + { + "input": "Concept: Visilizumab (Monoclonal Antibodies)", + "output": "Immunologic Factor described as a humanized, non-Fc receptor (FcR)-binding IgG2 monoclonal antibody (MoAb) directed against CD3 with potential immunosuppressive activity. Visilizumab binds to invariant CD3 epsilon, one of the non-covalently-associated subunits of T-cell receptors (TCRs) on activated T-cells. Upon binding to the TCR/CD3 complex, visilizumab induces apoptosis, which may result in the selective clonal deletion of activated pathogenic T-cells. This MoAb is engineered with a substitution at amino acid residues 234 and 237 (Val3Ala) within the IgG2 Fc arm, rendering it unable to bind to type II FcRs; accordingly, this agent is less likely to activate type II FcR-expressing resting T-cells." + }, + { + "input": "Concept: Escherichia coli, Extended-spectrum Beta-lactamases (Extended spectrum beta-lactamase-producing bacteria)", + "output": "something described as any bacterial organism that can be assigned to the species Escherichia coli and produces extended-spectrum beta-lactamases (ESBL)." + }, + { + "input": "Concept: Epipetrum Phil., 1864 (Plant)", + "output": "Dioscoreaceae described as a plant genus best known for edible underground tubers. Yam may also refer to a moist variety of sweet potato, IPOMOEA BATATAS." + }, + { + "input": "Concept: Cost Function (Qualitative Concept)", + "output": "algorithm described as a function or expression that is either maximized or minimized in order to obtain the optimal solution for a mathematical problem." + }, + { + "input": "Concept: antigen presentation, exogenous antigen (Cell Function)", + "output": "Cell Function described as the process in which an antigen-presenting cell expresses antigen (peptide or lipid) of exogenous origin on its cell surface in association with an MHC protein complex." + }, + { + "input": "Concept: TSCYC - Bad Dreams or Nightmares (TSCYC Questionnaire Question)", + "output": "Intellectual Product described as trauma Symptom Checklist for Young Children (TSCYC) Please indicate how often he or she has done, felt, or experienced each of the following things in the last month: Bad dreams or nightmares." + }, + { + "input": "Concept: Abnormality of skin physiology (Pathologic Function)", + "output": "Pathologic Function described as any abnormality of the physiological function of the skin." + }, + { + "input": "Concept: Macrophage Inflammatory Protein (Amino Acid, Peptide, or Protein)", + "output": "chemokine described as heparin-binding proteins which exhibit inflammatory and immunoregulatory activities; they are produced by a variety of cell types including neutrophils, fibroblasts, and epithelial cells; they most likely play a significant role in respiratory tract defenses." + }, + { + "input": "Concept: up-regulation of carboxyl protease activity involved in amyloid precursor protein degradation (positive regulation of aspartic-type peptidase activity)", + "output": "positive regulation of endopeptidase activity described as any process that activates or increases the frequency, rate or extent of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process." + }, + { + "input": "Concept: Test Result Report (Report)", + "output": "Report described as an account of the outcome of an analysis or test." + }, + { + "input": "Concept: Esophagus Squamous Cell Papilloma (Esophageal Neoplasms)", + "output": "Benign neoplasm of esophagus described as a rare neoplasm arising from the distal third of the esophagus. Morphologically, it is characterized by the presence of fibrovascular cores covered by mature stratified squamous epithelium. Progression to squamous cell carcinoma is extremely rare." + }, + { + "input": "Concept: Environmental Estrogen (Organic Chemical)", + "output": "estrogens described as environmental Estrogens are a variety of natural and synthetic substances that may mimic natural estrogen hormones." + }, + { + "input": "Concept: Allergic Alveolitides, Extrinsic (Allergic disorder of respiratory tract)", + "output": "Allergic conditions NEC described as conditions in which inhalation of organic dusts results in hypersensitivity reactions at the alveolar level, associated with the production of precipitins." + }, + { + "input": "Concept: Kadish Stage B Olfactory Neuroblastoma (Olfactory Neuroblastoma)", + "output": "something described as an olfactory neuroblastoma that involves the nasal cavity and paranasal sinuses." + }, + { + "input": "Concept: Distal Bile Duct Cancer Clinical TNM Finding v7 (Finding)", + "output": "Distal Bile Duct Cancer TNM Finding v7 described as a clinical finding about one or more characteristics of distal bile duct cancer, following the rules of the TNM AJCC v7 classification system. The clinical evaluation usually depends on the results of ultrasonography, contrast-enhanced multidetector computerized tomography (CT), or magnetic resonance cholangiopancreatography (MRCP), including arterial and portal venous phases, with thin sections whenever possible. Clinical staging may also be based on findings from surgical exploration when the main tumor mass is not resected." + }, + { + "input": "Concept: Undesired Sedation Score 2 (Intellectual Product)", + "output": "Undesired Sedation Scale described as a subjective score of 2 on a scale that ranges from 0: No undesired sedation at all to 10: undesired sedation as bad as it can be." + }, + { + "input": "Concept: Template-Activating Factor I (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as protein SET (290 aa, ~33 kDa) is encoded by the human SET gene. This protein is involved in the modulation of apoptosis, transcription, and nucleosome assembly." + }, + { + "input": "Concept: HADS0106 (Intellectual Product)", + "output": "HADS Questionnaire Question described as hospital Anxiety and Depression Scale (HADS) I feel cheerful." + }, + { + "input": "Concept: Organization Assigning a Unique Protocol Identifer (Organization)", + "output": "Organization described as the name of the organization who issued the extension or identifier." + }, + { + "input": "Concept: capgras' syndrome (Syndrome)", + "output": "Schizophrenia Spectrum and Other Psychotic Disorders described as a psychotic disorder characterized by the patient's belief that acquaintances or closely related persons have been replaced by doubles or imposters." + }, + { + "input": "Concept: Grade 3 Tracheal mucositis (Finding)", + "output": "Finding described as severe pain; hemorrhage or respiratory symptoms; limiting self care ADL" + }, + { + "input": "Concept: allantoin:proton symporter activity (amide transmembrane transporter activity)", + "output": "solute:proton symporter activity described as enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: allantoin(out) + H+(out) = allantoin(in) + H+(in) by secondary active transport." + }, + { + "input": "Concept: Protocol Review Chair (Chairperson)", + "output": "Study Personnel described as the presiding officer of a meeting, organization, or committee that is responsible for the analysis and evaluation of the detailed plan that sets forth the objectives, study design, and methodology for a clinical trial." + }, + { + "input": "Concept: sweet taste receptor activity (Molecular Function)", + "output": "gustatory receptor activity described as combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste." + }, + { + "input": "Concept: 3-alpha-Hydroxy-8-methyl-1-alpha-H,5-alpha-H-tropanium bromide mandelate (Carboxylic acid and carboxylic acid derivative)", + "output": "Anticholinergic Agents described as the methylbromide salt of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties. Homatropine methylbromide, a competitive inhibitor of acetylcholine at the muscarinic receptor, blocks parasympathetic nerve stimulation, thereby inhibiting pepsin and gastrin secretion. When administered in high doses, this drug produces inhibitory effects on acetylcholine activity, specifically on smooth muscle located in the gastrointestinal, biliary, and genitourinary tracts, resulting in an anti-spasmodic effect." + }, + { + "input": "Concept: min*mg/mL/m2 (Measurement Unit Description)", + "output": "Measurement Unit Description described as minutes times milligrams per milliliter (area under the curve), divided by meters squared (surface area)." + }, + { + "input": "Concept: Transplantation, Skin (Tissue Transplantation)", + "output": "Organ Transplantation described as the grafting of skin from one location to another in an attempt to replace a segment that is lost or damaged beyond repair." + }, + { + "input": "Concept: EFFRGOA (cardiac ultrasound)", + "output": "cardiac ultrasound described as a measurement of the effective regurgitant orifice area of the valve." + }, + { + "input": "Concept: Have Easy Access to the Medical Specialists I Need (Clinical or Research Assessment Question)", + "output": "Clinical or Research Assessment Question described as a question about whether an individual feels they have easy access to the medical specialists they need." + }, + { + "input": "Concept: Chemical Oxygen Demand Analysis (Laboratory Procedure)", + "output": "something described as testing for the amount of biodegradable and unbiodegradable organic material in a water sample by measuring the quantity of oxygen consumed via use of an oxidizing agent such as potassium dichromate. The COD test results correlate to the BOD results and can be acquired in a short enough time to be useful for wastewater management." + }, + { + "input": "Concept: FASCIOLOPSIS BUSKI (Fasciolopsis)", + "output": "Fasciolopsis described as a species of parasitic tremadoda flatworms in the family Fasciolidae. The life cycle of F. buski involes snails as the intermediate host and pigs and humans as the definitive host. It is the largest intestinal fluke of humans." + }, + { + "input": "Concept: Dermatofibrosarcomas (Soft Tissue Neoplasms)", + "output": "Fibrosarcoma described as a sarcoma of the deep layers of the skin. The tumors are locally aggressive tends to recur but rarely metastatic. It can be classified into variants depending on the cell type tumors are derived from or by its characteristics: Pigmented variant from MELANIN-containing DERMAL DENDRITIC CELLS; Myxoid variant, myxoid STROMAL CELLS; Giant cell variant characterized by GIANT CELLS in the tumors; and Fibrosarcomatous variant chracterized by tumor areas histologically indistinguishable from FIBROSARCOMA." + }, + { + "input": "Concept: inhibition of cysteine-type endopeptidase activity involved in apoptotic process (Molecular Function)", + "output": "inhibition of cysteine-type endopeptidase activity described as any process that prevents the activation of an inactive cysteine-type endopeptidase involved in an apoptotic process." + }, + { + "input": "Concept: PODCI1-Gym Limited by: Instructions (Intellectual Product)", + "output": "Intellectual Product described as pediatric Outcomes Data Collection Instrument, Pediatric Parent-Reported Version (PODCI Pediatric Parent-Reported Version) If you answered \"sometimes\" or \"never or rarely\" to Question 66 above, was your child's activity limited by: Doctor or parent instructions?" + }, + { + "input": "Concept: 5p15.33 (Chromosome band)", + "output": "Cell Component described as a chromosome band present on 5p" + }, + { + "input": "Concept: spindle pole body separation (Cell Function)", + "output": "something described as the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that is severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar spindle to assemble." + }, + { + "input": "Concept: hydroxyhyoscyamine dioxygenase activity (2-oxoglutarate-dependent dioxygenase activity)", + "output": "something described as catalysis of the reaction: (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O(2) = CO(2) + H(2)O + H(+) + scopolamine + succinate." + }, + { + "input": "Concept: Salivary Gland Sclerosing Polycystic Adenosis (Benign tumor of salivary gland)", + "output": "Neoplastic Process described as a rare, benign, well-circumscribed salivary gland neoplasm that predominantly affects females. It is characterized by the presence of microcysts, ducts, and acini in a sclerotic stroma. Focal lymphocytic infiltrates may also be present." + }, + { + "input": "Concept: hUCRP (ISG15 gene)", + "output": "ISG15 gene described as human ISG15 wild-type allele is located in the vicinity of 1p36.33 and is approximately 1 kb in length. This allele, which encodes ubiquitin-like protein ISG15, plays a role in type I interferon signaling." + }, + { + "input": "Concept: Group I (Intellectual Product)", + "output": "something described as localized disease, excised." + }, + { + "input": "Concept: Procedure Kit/Trays, Biopsy, Aspiration, Breast Duct Cell (Procedure Kit/Trays, Biopsy, Aspiration)", + "output": "Procedure Kit/Trays, Biopsy, Aspiration described as prepackaged collections of the devices and supplies (either custom or standard) needed for obtaining a sample of cells intended for biopsy from the breast milk ducts by suction through a fine needle. Items in these kits usually include an aspirator (e.g., a transparent port attached to a syringe) to identify the nipple ducts, very thin dilators to facilitate ductal cannulation, a blunt catheter to infuse and collect fluid to and from the breast ducts, and a vial to collect and transport the cells for cytological analysis in the laboratory (in a manner similar to the way a Pap smear is performed). The kits may be supplied in supporting trays (i.e., procedure trays) consisting of a flat-bottomed receptacle with a border around the periphery supporting all the instruments and supplies needed for the procedure; the trays are usually covered or wrapped. Breast ductal cell procedure kits and trays are intended for use in healthcare facilities (e.g., hospitals, doctors' offices) for obtaining and preparing breast ductal smears of women at high risk for developing breast cancer." + }, + { + "input": "Concept: HIVEP2-related intellectual disability (nervous system disorder)", + "output": "something described as a neurological disorder with characteristics of moderate to severe developmental delay and intellectual disability and mild dysmorphic features. Early symptoms include hypotonia, delayed development of motor skills, speech delay, hypertelorism, broad nasal bridge, and fingers with tapered ends. Other features include microcephaly, seizures, recurrent ear infections, strabismus, amblyopia and hyperopia. Behavioral problems such as hyperactivity, attention deficit disorder, aggression, anxiety and autism spectrum occur in some cases. Caused by mutations in the HIVEP2 gene leading to a shortage of functional HIVEP2 protein. Inherited in an autosomal dominant pattern however most cases of this condition result from de novo mutations in the gene." + }, + { + "input": "Concept: Enterococcus (ex Thiercelin and Jouhaud 1903) Schleifer and Kilpper-Balz 1984 (Streptococcus Lancefield group D)", + "output": "Bacteria described as any bacteria that is not assigned to the species level but can be assigned to the Enterococcus genus level." + }, + { + "input": "Concept: PICP (Protein or Enzyme Type Measurement)", + "output": "something described as the determination of the amount of procollagen type I carboxy terminal peptide present in a sample." + }, + { + "input": "Concept: Magnetis poli ambo (Pharmacologic Substance)", + "output": "something described as both poles of the magnet." + }, + { + "input": "Concept: X-linked Recessive (X-linked inheritance)", + "output": "Mode of inheritance described as a mode of inheritance that is observed for recessive traits related to a gene encoded on the X chromosome. In the context of medical genetics, X-linked recessive disorders manifest in males (who have one copy of the X chromosome and are thus hemizygotes), but generally not in female heterozygotes who have one mutant and one normal allele." + }, + { + "input": "Concept: DNA duplex unwinding involved in mitotic DNA replication (mitotic cell cycle process)", + "output": "something described as any DNA duplex unwinding involved in mitotic cell cycle DNA replication." + }, + { + "input": "Concept: ftrhrs care ntil 10pm narr r (Extended services with or without ICD diagnosis)", + "output": "Therapeutic or Preventive Procedure described as providing after-hours care to a client/patient until 10 p.m., narrative required." + }, + { + "input": "Concept: phantom (Equipment and Supplies)", + "output": "Imaging Device described as devices or objects in various imaging techniques used to visualize or enhance visualization by simulating conditions encountered in the procedure. Phantoms are used very often in procedures employing or measuring x-irradiation or radioactive material to evaluate performance. Phantoms often have properties similar to human tissue. Water demonstrates absorbing properties similar to normal tissue, hence water-filled phantoms are used to map radiation levels. Phantoms are used also as teaching aids to simulate real conditions with x-ray or ultrasonic machines." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Deletion, 5q (IVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Deletion)", + "output": "Medical Device described as molecular assay reagents intended for use in identifying deletions in the long arm of chromosome 5 (i.e., 5q). 5q deletions have been observed in patients with certain hematologic malignancies and may be associated with poor prognosis in certain hematologic malignancies, including acute myeloid leukemia." + }, + { + "input": "Concept: N-Myristoylation (Protein Acetylation)", + "output": "something described as n-Myristoylation is the covalent attachment of myristic acid, a saturated 14-carbon fatty acid inserted in the cytoplasmic leaflet of the lipid bilayer, by an amide linkage to the amino-terminal glycine residue of a protein in order to increase the hydrophobicity of some membrane proteins or to promote membrane localization of some cytoplasmic proteins." + }, + { + "input": "Concept: Duodenum/Ampulla/Jejunum/Ileum Neuroendocrine Tumor Pathologic Primary Tumor TNM Finding v7 (Finding)", + "output": "Gastrointestinal Neuroendocrine Tumor Pathologic TNM Finding v7 described as a pathologic finding about one or more characteristics of duodenum/ampulla/jejunum/ileum neuroendocrine tumor, following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor." + }, + { + "input": "Concept: PQL05-Legs Hurt (Intellectual Product)", + "output": "something described as pediatric Quality of Life Neuromuscular Module Version 3 Child - In the past one month, how much of a problem has this been for you: My legs hurt." + }, + { + "input": "Concept: (3beta,16beta,17alpha,18beta,20alpha)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic Acid Methyl Ester (Catecholamine-depleting Sympatholytics [EPC])", + "output": "Multidrug Resistance Modulator described as alkaloid isolated from the root of Rauwolfia species, used as an antihypertensive and sedative." + }, + { + "input": "Concept: Have Shiny Skin Scar (Clinical or Research Assessment Question)", + "output": "Clinical or Research Assessment Question described as a question about whether an individual has or had a shiny scar." + }, + { + "input": "Concept: FAC071-Able to Do My Usual Activities (Intellectual Product)", + "output": "FACIT-F Version 4 Questionnaire Question described as functional Assessment of Chronic Illness Therapy-Fatigue Version 4 (FACIT-F Version 4) Additional Concerns: I am able to do my usual activities." + }, + { + "input": "Concept: ethics committees (Professional Staff Committees)", + "output": "something described as committees established by professional societies, health facilities, or other institutions to consider decisions that have bioethical implications. The role of these committees may include consultation, education, mediation, and/or review of policies and practices. Committees that consider the ethical dimensions of patient care are ETHICS COMMITTEES, CLINICAL; committees established to protect the welfare of research subjects are ETHICS COMMITTEES, RESEARCH." + }, + { + "input": "Concept: myoblast fate commitment in head (Cell Function)", + "output": "Cell Function described as the process, taking place in the head, whereby the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." + }, + { + "input": "Concept: FAMS0103 (Intellectual Product)", + "output": "something described as functional Assessment of Multiple Sclerosis (FAMS) Mobility: I have trouble walking." + }, + { + "input": "Concept: Santali albi / tan xiang (Oriental herbs and natural substances letter S)", + "output": "Plant described as tan xiang" + }, + { + "input": "Concept: response to G1 cell size control checkpoint signaling (Cell Function)", + "output": "Cell Function described as a process that occurs in response to signals generated as a result of mitotic cell cycle G1/S transition size control checkpoint signaling." + }, + { + "input": "Concept: Western Ontario and McMaster Universities Osteoarthritis Index Version 3.1 Likert Scale Format Questionnaire (Intellectual Product)", + "output": "Clinical or Research Assessment Questionnaire described as a standardized rating scale developed by Nicholas Bellamy with the Western Ontario and McMaster Universities in 1982, which is used to assess pain, stiffness, and physical function in patients with hip and/or knee osteoarthritis. The questionnaire contains 24 items which are divided into 3 subscales: pain, stiffness and physical function. This version of the questionnaire uses the 5-point Likert scaling format." + }, + { + "input": "Concept: 1H-Imidazole-1-acetamide, N-(2-hydroxyethyl)-2-nitro- (Pharmacologic Substance)", + "output": "Organic Chemical described as a drug that increases the effectiveness of radiation therapy." + }, + { + "input": "Concept: Transient Receptor Potential Cation Channel Subfamily A Member 1 (Amino Acid, Peptide, or Protein)", + "output": "Ion Channel Protein described as transient receptor potential cation channel subfamily A member 1 (1119 aa, ~128 kDa) is encoded by the human TRPA1 gene. This protein plays a role in ion transport and the detection of pain." + }, + { + "input": "Concept: Glycohemoglobin (Protein measurement)", + "output": "Carbohydrate tolerance analyses described as a measurement of the glycosylated hemoglobin A1C in a biological specimen." + }, + { + "input": "Concept: stage III marginal zone lymphoma (B-cell lymphoma stage III)", + "output": "Marginal zone lymphomas NEC described as stage III: involvement of lymph node regions on both sides of the diaphragm (III) that may also be accompanied by localized involvement of an extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or both (IIIS+E). (PDQ) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C68682\" active clinical trials using this agent." + }, + { + "input": "Concept: Did Not Lift Something Weighing 10-20 Pounds (Intellectual Product)", + "output": "Clinical or Research Assessment Question described as a question about the reason why an individual did not lift something weighing 10-20 pounds." + }, + { + "input": "Concept: Supervisors of Installation, Maintenance, and Repair Workers (Professional or Occupational Group)", + "output": "something described as workers who directly supervise and coordinate the activities of mechanics, installers, and repairers." + }, + { + "input": "Concept: Stage IV Small Cell Lung Cancer (Stage IV Lung Cancer AJCC v7)", + "output": "something described as stage IV includes: (Any T, Any N, M1a); (Any T, Any N, M1b). M1a: Lung cancer with separate tumor nodule(s) in a contralateral lobe; tumor with pleural nodules or malignant pleural (or pericardial) effusion. M1b: Distant metastasis." + }, + { + "input": "Concept: Amphotericin B (Polyenes)", + "output": "antibiotics, intestinal described as a polyene antifungal antibiotic produced by Streptomyces nodosus, with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane, thereby causing depolarization of the membrane and altering cell membrane permeability. This leads to leakage of important intracellular components, cell rupture, and eventually cell death. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells." + }, + { + "input": "Concept: dibenzofuran metabolism (heterocycle metabolic process)", + "output": "Molecular Function described as the chemical reactions and pathways involving dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond. Dibenzofuran is a white crystalline solid created from the production of coal tar and used as an insecticide and an intermediate in the production of other chemicals." + }, + { + "input": "Concept: Frames (Support equipment)", + "output": "Medical Device described as an enclosing border." + }, + { + "input": "Concept: Polymorphic focal epileptiform discharges (EEG with focal epileptiform discharges)", + "output": "something described as focal epileptiform discharges of different shapes and frequencies." + }, + { + "input": "Concept: Grade 3 Enterocolitis Infectious, CTCAE (Enterocolitis Infectious, CTCAE)", + "output": "something described as IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated; profuse watery diarrhea with signs of hypovolemia; bloody diarrhea; fever; severe abdominal pain; hospitalization indicated" + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Epidemic Parotitis (Mumps), RNA (Medical Device)", + "output": "something described as molecular assay reagents intended to identify epidemic parotitis (mumps) virus, an RNA virus of the family Paramyxoviridae, by detecting the ribonucleic acid (RNA) of the target virus. This virus is the etiologic agent of epidemic parotitis (also known as mumps), an infection characterized by swelling of one or both parotid glands that may also affect the pancreas, cause inflammation of the testes (orchitis) and affect the ovaries." + }, + { + "input": "Concept: Limited in Doing Work or Daily Activities (Intellectual Product)", + "output": "something described as a question about whether an individual limits or was limited in performing work or daily activities." + }, + { + "input": "Concept: actin patch (Cell Component)", + "output": "endocytic patch described as an endocytic patch that consists of an actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae." + }, + { + "input": "Concept: Factor VIIa Activity Measurement (Blood coagulation tests)", + "output": "Laboratory Procedure described as the determination of the amount of the biological activity of factor VIIa in a sample." + }, + { + "input": "Concept: Study Protocol Version (Intellectual Product)", + "output": "Intellectual Product described as a plan at a particular point in time for a formal investigation to assess the utility, impact, pharmacological, physiological, and/or psychological effects of a particular treatment, procedure, drug, device, biologic, food product, cosmetic, care plan, or subject characteristic." + }, + { + "input": "Concept: PLW (Country)", + "output": "Country described as a country in the Pacific, comprising a group of islands in the North Pacific Ocean, southeast of the Philippines and northwest of Papua New Guinea." + }, + { + "input": "Concept: Muscarinic receptor antagonist-containing product (Cholinergic Antagonists)", + "output": "Substance categorized by disposition described as drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system." + }, + { + "input": "Concept: Barbadian race (Black Caribbean)", + "output": "Black Caribbean described as a person having origins in any of the original peoples of Barbados." + }, + { + "input": "Concept: Volatile Organic Compounds (Organic Chemicals)", + "output": "Organic Chemical described as organic compounds that have a relatively high VAPOR PRESSURE at room temperature." + }, + { + "input": "Concept: Severe Dysplasia of Uterine Cervix AJCC v7 (Cervical Cancer by AJCC v7 Stage)", + "output": "Neoplastic Process described as stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis. FIGO no longer includes stage 0." + }, + { + "input": "Concept: Astrocytoma of the Optic Nerve (Optic Nerve Glioma)", + "output": "Visual Pathway Astrocytoma described as an astrocytoma occurring in the optic nerve." + }, + { + "input": "Concept: Labiatae (Angiosperm)", + "output": "Plant described as a plant family of aromatic herbs and shrubs having flowers resembling the lips of a mouth and four-lobed ovaries yielding four one-seeded nutlets which includes the mints, thyme, sage, and rosemary." + }, + { + "input": "Concept: Old or Age Indeterminate Anterior Myocardial Infarction by ECG Finding (Finding)", + "output": "something described as an electrocardiographic finding of pathologic Q waves in leads V3 and V4, which is suggestive of myocardial infarction of the anterior wall of the left ventricle, without evidence of current or ongoing acute infarction." + }, + { + "input": "Concept: XPO1 wt Allele (XPO1 gene)", + "output": "Gene or Genome described as human XPO1 wild-type allele is located in the vicinity of 2p15 and is approximately 61 kb in length. This allele, which encodes exportin-1 protein, is involved in the modulation of nuclear transport." + }, + { + "input": "Concept: Neurotropic Tyrosine Kinase Receptor Type 2 Deficiency (Finding)", + "output": "Melanocortin Pathway Defect described as presumed loss-of-function mutation(s) in the NTKR2 gene, resulting in deficiency or dysfunction of the type 2 receptor for the enzyme neurotropic tyrosine kinase." + }, + { + "input": "Concept: Behavior, Choice (Decision Making)", + "output": "something described as act of making a selection among two or more alternatives, usually after a period of deliberation." + }, + { + "input": "Concept: HLA-DP0401/0402-restricted, MAGE-A3-reactive T cell receptor-transduced autologous T cells (therapeutic autologous lymphocytes)", + "output": "something described as human autologous T-lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the human leukocyte antigen (HLA)-DP0401/0402-restricted, melanoma antigen A3 (MAGE-A3), with potential antineoplastic activity. CD4-positive cells are isolated from a patient, transduced with an anti-MAGE-A3-DP0401/0402 restricted TCR, expanded ex vivo, and reintroduced into the HLA-DP0401/0402 positive patient. Then, the HLA-DP0401/0402-restricted, MAGE-A3-reactive TCR-transduced autologous T cells bind to tumor cells expressing the MAGE-A3 antigen, which may result in both an inhibition of growth and increased cell death for MAGE-A3-expressing cancer cells. The tumor-associated antigen MAGE-A3 is overexpressed by a variety of cancer cell types." + }, + { + "input": "Concept: response to host immune response (response to host defenses)", + "output": "something described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." + }, + { + "input": "Concept: epilepsy; cerebral (Neurologic)", + "output": "Brain and Nerves described as brain disorder characterized by recurring excessive neuronal discharge, exhibited by transient episodes of motor, sensory, or psychic dysfunction, with or without unconsciousness or convulsive movements." + }, + { + "input": "Concept: Neonatal alloimmune thrombocytopenia (Immune and associated conditions NEC)", + "output": "Haematological disorders congenital NEC described as low platelet count associated with maternal platelet-specific alloantibodies." + }, + { + "input": "Concept: Ovarian ablation (Therapeutic or Preventive Procedure)", + "output": "Genitourinary therapy described as surgery, radiation therapy, or a drug treatment to stop the functioning of the ovaries." + }, + { + "input": "Concept: RAD18 (Ubiquitin-Transferase Gene)", + "output": "DNA Repair Gene described as this gene plays a role in both protein ubiquitination and DNA repair." + }, + { + "input": "Concept: PDGF receptor binding (growth factor receptor binding)", + "output": "growth factor receptor binding described as interacting selectively and non-covalently with the platelet-derived growth factor receptor." + }, + { + "input": "Concept: Chamomile (Plant)", + "output": "Asteraceae described as common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia." + }, + { + "input": "Concept: Marketed as OTC Monograph Drug Product Manufactured Exclusively for Private Label Distributor (Structured Product Labeling Marketing Category)", + "output": "something described as a marketing category specifying that an OTC monograph drug product is manufactured and packaged exclusively for a Private Label Distributor, and not otherwise marketed by the drug product's manufacturer." + }, + { + "input": "Concept: CSF-Cerebrospnl fluid otorhoea (Ear discharge)", + "output": "Ear discharge described as discharge of cerebrospinal fluid through the ear structures." + }, + { + "input": "Concept: Fecal Immunochemical Test (Fecal occult blood test)", + "output": "Fecal occult blood test described as a fecal occult blood test that uses an immunological assay to detect hemoglobin in stool." + }, + { + "input": "Concept: sbsqnt 20min out-ofc Orntl (Therapeutic or Preventive Procedure)", + "output": "Therapeutic or Preventive Procedure described as using Oriental diagnostic methods in a usual, subsequent, 20-minute, in-office meeting to assess the health status of an existing Oriental medicine client to reevaluate and/or develop an Oriental medicine treatment plan. Use for client/patient assessment and/or history." + }, + { + "input": "Concept: Psychomotor degeneration (Central Nervous System)", + "output": "Mental deterioration described as loss of previously present mental and motor abilities." + }, + { + "input": "Concept: injury radiation osteoradionecrosis (Injury of musculoskeletal system)", + "output": "Musculoskeletal necrosis and vascular insufficiency described as necrosis of bone following exposure to a source of radiation." + }, + { + "input": "Concept: Wnt protein secretion (Protein Secretion)", + "output": "signal release described as the controlled release of a Wnt protein from a cell." + }, + { + "input": "Concept: negative regulation of PPAR signaling pathway (regulation of peroxisome proliferator activated receptor signaling pathway)", + "output": "Molecular Function described as any process that stops, prevents, or reduces the frequency, rate or extent of the peroxisome proliferator activated receptor signaling pathway." + }, + { + "input": "Concept: Vicriviroc (Anti-HIV Agents)", + "output": "something described as a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus. Vicriviroc is designed to bind to CCR5 and inhibit the entry of HIV into CD4 cells." + }, + { + "input": "Concept: negative regulation of mitochondrial protein synthesis (Genetic Function)", + "output": "Genetic Function described as any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA in a mitochondrion." + }, + { + "input": "Concept: Haematopoietic (Hemic and Immune Systems)", + "output": "Adult human body described as the bodily system of organs and tissues, primarily the bone marrow, spleen, tonsils, and lymph nodes, involved in the production of blood." + }, + { + "input": "Concept: Submission Unit Effective Date Range (Temporal Concept)", + "output": "Temporal Concept described as he date and time span for when the submission unit is active." + }, + { + "input": "Concept: Probabilty Sampling (Sampling - Surgical action)", + "output": "sample by method of selection described as a sample derived by selecting sampling units (e.g., individual patients) such that each unit has an independent and fixed (generally equal) chance of selection. Whether or not a given unit is selected is determined by chance, for example, by a table of randomly ordered numbers." + }, + { + "input": "Concept: IMETELSTAT (Pharmacologic Substance)", + "output": "Nucleic Acid, Nucleoside, or Nucleotide described as a synthetic lipid-conjugated, 13-mer oligonucleotide N3'-P5'-thio-phosphoramidate with potential antineoplastic activity. Complementary to the template region of telomerase (hTR) RNA, imetelstat acts as a competitive enzyme inhibitor that binds and blocks the active site of the enzyme (a telomerase template antagonist), a mechanism of action which differs from that for the antisense oligonucleotide-mediated inhibition of telomerase activity through telomerase mRNA binding. Inhibition of telomerase activity in tumor cells by imetelstat results in telomere shortening, which leads to cell cycle arrest or apoptosis." + }, + { + "input": "Concept: Malignant nipple neoplasm male (Neoplastic Process)", + "output": "Benign and malignant breast neoplasms described as a malignant neoplasm that affects the area of the nipple in males." + }, + { + "input": "Concept: Amlodipinum (Dihydropyridine derivative calcium channel blocker)", + "output": "Dihydropyridine derivative described as a drug used to treat high blood pressure and chest pain" + }, + { + "input": "Concept: High Intensity Light or Pulse Light Sterilization (Sterilization for infection control)", + "output": "something described as a sterilization process that uses intense and short duration pulses of wavelengths of light from the ultraviolet to the near infrared regions to kill microorganisms." + }, + { + "input": "Concept: Tandem Brachytherapy (Low dose rate brachytherapy)", + "output": "Therapeutic or Preventive Procedure described as an internal radiation treatment technique in which a small metal tube filled with a radioactive source is placed inside the uterus for the treatment of gynecological cancers." + }, + { + "input": "Concept: Curcumin/Green Tea Extract/Polygonum cuspidatum Extract/Soybean Extract Capsule (Pharmacologic Substance)", + "output": "Dietary Supplements described as an oral capsule containing curcumin, green tea extract, Polygonum cuspidatum extract, and soybean extract, with antioxidant and potential chemopreventive activities. The antioxidants in curcumin/green tea extract/Polygonum cuspidatum extract/soybean extract capsule bind to and neutralize free-radicals, which may prevent their genotoxic and carcinogenic effects." + }, + { + "input": "Concept: compliance lung (Pulmonary function tests)", + "output": "Thoracic compliance described as the capability of the LUNGS to distend under pressure as measured by pulmonary volume change per unit pressure change. While not a complete description of the pressure-volume properties of the lung, it is nevertheless useful in practice as a measure of the comparative stiffness of the lung." + }, + { + "input": "Concept: storage in vacuole (Cell Function)", + "output": "Cell Function described as the process of transporting a substance into, and confining within, a vacuole." + }, + { + "input": "Concept: MEDIASTINUM, ANTERIOR (Mediastinum)", + "output": "Structure of thorax, including mediastinum and diaphragm described as the area in the front part of the chest between the lungs." + }, + { + "input": "Concept: sycotic bacillus/organism th (Homeopathic remedies letter S)", + "output": "something described as sycotic bacillus, causes sycotic miasm, also expressed by ridged nails." + }, + { + "input": "Concept: PHQ03-Problems Made It Difficult to Work (PHQ Screener Version Questionnaire Question)", + "output": "PHQ Screener Version Questionnaire Question described as patient Health Questionnaire Screener Version (PHQ Screener Version) If you checked off any problems on this questionnaire, how difficult have these problems made it for you to do your work, take care of things at home, or get along with other people?" + }, + { + "input": "Concept: Superior Intercostal Vein (Veins)", + "output": "something described as either of two veins (left or right) that drain the second, third, and fourth intercostal spaces. The right superior intercostal vein drains into the right azygos vein while the left superior intercostal vein drains into the left innominate vein." + }, + { + "input": "Concept: Demeclociclina (D [Preparations])", + "output": "D [Preparations] described as a TETRACYCLINE analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time." + }, + { + "input": "Concept: pg/mL/m2 (Unit of concentration)", + "output": "Quantitative Concept described as a unit of concentration equal to picograms per milliliter, divided by meters squared." + }, + { + "input": "Concept: Pneumoparotid (Disease or Syndrome)", + "output": "something described as enlargement of the parotid gland due to air insufflation." + }, + { + "input": "Concept: Cervical Cancer pT0 TNM Finding v7 (Finding)", + "output": "something described as cervical cancer with no evidence of primary tumor." + }, + { + "input": "Concept: Accessory index finger phalanges (Anatomical Abnormality)", + "output": "Pseudoepiphyses of the phalanges of the hand described as a secondary ossification center in the second finger that is distinct from the normal epiphysis that does not contribute to the longitudinal growth of a tubular bone." + }, + { + "input": "Concept: Amoeba (Tubulina)", + "output": "Protozoa described as a genus of ameboid protozoa. Characteristics include a vesicular nucleus and the formation of several PSEUDOPODIA, one of which is dominant at a given time. Reproduction occurs asexually by binary fission." + }, + { + "input": "Concept: regulation of leaf formation (regulation of plant organ formation)", + "output": "regulation of plant organ formation described as any process that modulates the frequency, rate or extent of leaf formation." + }, + { + "input": "Concept: P2 Hydronephrosis (Hydronephrosis)", + "output": "Hydronephrosis described as postnatal Hydronephrosis with the following clinical findings: 1) APRPD is greater than or equal to 15 mm, 2) the calyces may be dilated centrally and peripherally, 3) or a dilated ureter is visible, 4) the parenchymal thickness and appearance is normal, and 5) the bladder is normal. Cases in which there is peripheral calyceal dilation but the APRPD is less than 15 mm are classified as UTD P2. (Adapted from: Hiep T. Nguyen, Carol B. Benson, Bryann Bromley, Jeffrey B. Campbell, Jeanne Chow, Beverly Coleman, Christopher Cooper, Jude Crino, Kassa Darge, C.D. Anthony Herndon, Anthony O. Odibo, Michael J.G. Somers, Deborah R. Stein; Multidisciplinary consensus on the classification of prenatal and postnatal urinary tract dilation (UTD classification system); Pediatric Urology; December 2014 Volume 10, Issue 6, Pages 982-998)" + }, + { + "input": "Concept: Childhood Optic Tract Astrocytoma (Visual Pathway Astrocytoma)", + "output": "Optic Nerve Glioma, Childhood described as an astrocytoma affecting the optic tract that occurs during childhood." + }, + { + "input": "Concept: Learning, Spatial (Academic Learning & Achievement)", + "output": "Academic Learning & Achievement described as a process through which individuals encode information about their environmental CUES to facilitate SPATIAL NAVIGATION." + }, + { + "input": "Concept: Congenital ectodermal defect (Dysplasia)", + "output": "Skin and subcutaneous malformations and anomalies NEC described as a group of inherited disorders characterized by malformations of the structures that derive from the ectoderm, such as hair, teeth, nails and sweat glands." + }, + { + "input": "Concept: Feel Exhausted Most of the Time (Intellectual Product)", + "output": "Clinical or Research Assessment Answer described as a response indicating that an individual feels or felt exhausted most of the time." + }, + { + "input": "Concept: Eubacterium lentum (Eggerthella)", + "output": "Eggerthella described as a species of aerobic, Gram positive, rod shaped bacterium in the phylum Actinobacteria. This species is non-fermenting, liquefies gelatin, reduces nitrate, does not hydrolyzes esculin or starch, nonhemolytic and catalase negative. E. lenta is a commensal organism of the gastrointestinal tract and is rarely associated with infections." + }, + { + "input": "Concept: systemic blood pressure (Blood Pressure)", + "output": "Arterial measure described as the blood pressure in the ARTERIES. It is commonly measured with a SPHYGMOMANOMETER on the upper arm which represents the arterial pressure in the BRACHIAL ARTERY." + }, + { + "input": "Concept: Carvedilol phosphate (Organic Chemical)", + "output": "something described as the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity. The S enantiomer of carvedilol nonselectively binds to and blocks beta-adrenergic receptors, thereby exerting negative inotropic and chronotropic effects, and leading to a reduction in cardiac output. In addition, both enantiomers of carvedilol bind to and block alpha 1-adrenergic receptors, thereby causing vasodilation and reducing peripheral vascular resistance." + }, + { + "input": "Concept: Constrictive Bronchiolitis (Disease or Syndrome)", + "output": "something described as a form that is characterized by partial or complete obstruction of bronchiolar lumens resulting from chronic bronchiolar inflammation, scarring, and smooth muscle hypertrophy." + }, + { + "input": "Concept: Verbal apraxia speech and language rehabilitation (Therapeutic or Preventive Procedure)", + "output": "something described as using speech and language rehabilitation therapy, including initiating, coordinating and/or sequencing muscle movement exercises, with a patient to improve his or her proper vocalization." + }, + { + "input": "Concept: CDISC Questionnaire SF36 v1.0 Acute Test Code Terminology (Intellectual Product)", + "output": "Unused Subset Concept described as test codes of questionnaire questions associated with the Short Form 36 Health Survey Acute, US Version 1.0 (SF36 v1.0 Acute) for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: Postmortem Chisels (Chisel, device)", + "output": "Medical Device described as chisels designed to cut and shape bone during procedures (e.g., autopsy, dissection) performed on the body following death (i.e., postmortem procedures). These chisels are typically a sturdy handheld, manual flat-blade instrument with a cutting edge that is beveled on one side at the distal end and an integral straight or, less frequently, cross handle. Postmortem chisels are used mainly during autopsy and cadaver dissection. Dedicated postmortem chisels are available to break and/or open cadaver skulls." + }, + { + "input": "Concept: inorganic magnesium compounds (Inorganic Chemical)", + "output": "something described as inorganic compounds that contain magnesium as an integral part of the molecule." + }, + { + "input": "Concept: SF-36 v2.0 Acute - Question 3i (SF36 v2 0 Acute Questionnaire Question)", + "output": "Intellectual Product described as the Short Form 36 Health Survey Acute, Version 2.0 (SF36 v2.0 Acute) Question 3i." + }, + { + "input": "Concept: Behavior, Paranoid (Individual Behavior)", + "output": "something described as behavior exhibited by individuals who are overly suspicious, but without the constellation of symptoms characteristic of paranoid personality disorder or paranoid type of schizophrenia." + }, + { + "input": "Concept: Atrial Tachycardia With AV Block by ECG Finding (Finding)", + "output": "Electrocardiogram finding described as an electrocardiographic finding of an atrial tachycardia which does not display 1:1 AV conduction." + }, + { + "input": "Concept: spore germination (Physiologic Function)", + "output": "Developmental process described as the physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth (e.g. emergence from a spore wall)." + }, + { + "input": "Concept: Moringa pterygosperma (Plant)", + "output": "Moringa described as a plant species of the family Moringaceae, order Capparales, subclass Dilleniidae. It is a source of niaziminin and hypotensive thiocarbamate glycosides." + }, + { + "input": "Concept: AIDS, Clinical Trials on Minorities (AIDS Clinical Trial)", + "output": "AIDS Clinical Trial described as AIDS clinical trials related to individuals of non-Caucasian descent." + }, + { + "input": "Concept: Semicircular canal, posterior (Bony labyrinth structure)", + "output": "Body Space or Junction described as the inferior portion of the semicircular canal found in the inner ear, which detects anterior and posterior rotation of the head." + }, + { + "input": "Concept: FAC017-I Am Sleeping Well (Intellectual Product)", + "output": "Intellectual Product described as functional Assessment of Cancer Therapy-Leukemia Version 4 (FACT-LEU Version 4) Functional Well-Being: I am sleeping well." + }, + { + "input": "Concept: non-sequence-specific DNA binding, bending (DNA binding, bending)", + "output": "DNA binding, bending described as the activity of binding selectively and non-covalently to DNA in a sequence-independent manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." + }, + { + "input": "Concept: Refractory cytopenia with multilineage dysplasia and ringed sideroblasts (Primary malignant neoplasm of bone marrow)", + "output": "Refractory cytopenia with multilineage dysplasia described as a myelodysplastic syndrome characterized by bi-cytopenia or pancytopenia, dysplastic changes in 10% or more of the cells in two or more of the myeloid cell lines, and 15% or more ring sideroblasts in the bone marrow." + }, + { + "input": "Concept: Marginal zone lymphoma stage II (Neoplastic Process)", + "output": "Neoplastic Process described as stage II: involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: the number of lymph node regions involved may be indicated by a subscript (e.g., II3). (PDQ) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C68679\" active clinical trials using this agent." + }, + { + "input": "Concept: downregulation of leucophore differentiation (negative regulation of pigment cell differentiation)", + "output": "regulation of leucophore differentiation described as any process that stops, prevents, or reduces the frequency, rate or extent of leucophore differentiation." + }, + { + "input": "Concept: chondroitins (Glycosaminoglycanoses marker)", + "output": "Glycosaminoglycanoses marker described as family of acetylgalactosamine mucopolysaccharides." + }, + { + "input": "Concept: Nuclear Reprogramming (Genetic Processes)", + "output": "Genetic Processes described as the process that reverts CELL NUCLEI of fully differentiated somatic cells to a pluripotent or totipotent state." + }, + { + "input": "Concept: Yersinia frederiksenii Ursing et al. 1981 (Bacterium)", + "output": "something described as any bacterial organism that can be assigned to the species Yersinia frederiksenii." + }, + { + "input": "Concept: Product containing strontium (Elements, Ions and Simple Compounds)", + "output": "Strontium and strontium compound described as element of the alkaline earth family of metals. It has the atomic symbol Sr, atomic number 38, and atomic weight 87.62." + }, + { + "input": "Concept: inflammatory soft tissue disorders serositis (Limb structure)", + "output": "Non-Neoplastic Soft Tissue Disorder described as inflammation in any serous cavity." + }, + { + "input": "Concept: FADY (Study Day)", + "output": "something described as the day of the week the findings about an event or intervention was collected." + }, + { + "input": "Concept: Stage IIA Small Cell Lung Carcinoma (Stage II Lung Small Cell Carcinoma AJCC v7)", + "output": "Stage II Lung Small Cell Carcinoma AJCC v7 described as stage IIA includes: (T2b, N0, M0); (T1a, N1, M0); (T1b, N1, M0); (T2a, N1, M0). T2b: Lung cancer with a tumor size more than 5 cm but 7 cm or less in greatest dimension. T1a: Lung cancer with a tumor size of 2 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus). The uncommon superficial tumor of any size with its invasive component limited to the bronchial wall, which may extend proximal to the main bronchus, is also classified as T1a. T1b: Lung cancer with a tumor size more than 2 cm but 3 cm or less in greatest dimension, surrounded by lung or visceral pleura and without bronchoscopic evidence of invasion more proximal than the lobar bronchus (i.e., not in the main bronchus). T2a: Lung cancer with a tumor size more than 3 cm but 5 cm or less in greatest dimension. N0: No regional lymph node metastasis. N1: Lung cancer with metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary lymph nodes, including involvement by direct extension. M0: No distant metastasis." + }, + { + "input": "Concept: Alendronate sodium - chemical (Diphosphonates)", + "output": "Organic Chemical described as the sodium salt of alendronate, a second generation bisphosphonate and synthetic analog of pyrophosphate with bone anti-resorption activity. Alendronate sodium binds to and inhibits the activity of geranyltranstransferase (farnesyl pyrophosphate synthetase), an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which is important in the process of osteoclast turnover. As a result, osteoclast activity is inhibited and bone resorption and turnover are reduced." + }, + { + "input": "Concept: Convolution (Shapes)", + "output": "something described as folded, curved and/or tortuous windings." + }, + { + "input": "Concept: GT-111 (Immunologic Factor)", + "output": "Immunologic Factor described as an adenovirus encoding an endothelial cell-specific, murine pre-proendothelin-1 (PPE-1) promoter and a Fas-based chimeric death receptor with potential anti-angiogenic activity. Endothelial cell-specific transcriptional control of the adenoviral vector is achieved by the use of a modified murine PPE-1 promoter that is specifically activated in PPE-1-expressing angiogenic endothelial cells residing in the tumor microvasculature. Subsequently, the Fas-c (Fas-chimeric) death receptor, containing Fas and tumor necrosis factor (TNF) receptor 1 (TNFR1) moieties, is expressed in angiogenic endothelial cells; endothelial cell-specific Fas-mediated apoptosis is initiated by the binding of TNF-alpha, abundant in the tumor microenvironment, to the TNFR1 moiety of the expressed Fas-c death receptor. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C71539\" active clinical trials using this agent." + }, + { + "input": "Concept: FREE RADICAL ASSAY, AMPHETAMINE (Indicator, Reagent, or Diagnostic Aid)", + "output": "something described as an amphetamine test system is a device intended to measure amphetamine, a central nervous system stimulating drug, in plasma and urine. Measurements obtained by this device are used in the diagnosis and treatment of amphetamine use or overdose and in monitoring levels of amphetamine to ensure appropriate therapy." + }, + { + "input": "Concept: formation of quadruple SL/U4/U5/U6 snRNP (Genetic Function)", + "output": "something described as formation of a quadruple snRNP complex composed of the spliced leader (SL) RNA along with the U4/U6-U5 tri-snRNP complex. Interactions that may facilitate this include a duplex between the SL and U6 RNAs and interactions between the U5 RNA and the exon sequence at the 5' splice site within the SL RNA." + }, + { + "input": "Concept: Barium sulfate [dup] (Inorganic Chemical)", + "output": "barium described as a compound used as an x-ray contrast medium that occurs in nature as the mineral barite. It is also used in various manufacturing applications and mixed into heavy concrete to serve as a radiation shield." + }, + { + "input": "Concept: NP 006209.2:p.His1047Gln (PIK3CA NP 006209.2:p.H1047X)", + "output": "Cell or Molecular Dysfunction described as a change in the amino acid residue at position 1047 in the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform protein where histidine has been replaced by glutamine." + }, + { + "input": "Concept: income maintenance (Financing, Organized)", + "output": "Financing, Organized described as insurance programs designed to compensate individuals based upon need due to unemployment, death of head of household, age, etc.; see narrower terms for disability or poverty based programs." + }, + { + "input": "Concept: Equal Education (Laws)", + "output": "Laws described as provision of comparable educational opportunities to all individuals irrespective of race, national origin, religion, sex, socioeconomic status, or ability." + }, + { + "input": "Concept: Psychological Conditioning (Conditioning and Stimulus Functions and Disorders)", + "output": "Conditioning and Stimulus Functions and Disorders described as simple form of learning involving the formation, strengthening, or weakening of an association between a stimulus and a response." + }, + { + "input": "Concept: Level 1 Morbidly Adherent Placentation (Intellectual Product)", + "output": "something described as level 1 Morbidly Adherent Placentation is defined by three criteria: first, evidence of placenta previa by either a second- or third-trimester ultrasound or an MRI; second, one of the following ultrasound features must be present: for Greyscale: a) Loss of the retroplacental sonolucent zone; OR b) Irregular retroplacental sonolucent zone; OR c) Thinning or disruption of the hyperechoic serosa-bladder interface; OR d) Presence of focal exophytic masses invading the urinary bladder; OR e) Abnormal placental lacunae; for Color Doppler: a) Diffuse or focal lacunar flow; OR b) Vascular lakes with turbulent flow (peak systolic velocity over 15 cm/s); OR c) Hypervascularity of serosa-bladder interface; OR d) Markedly dilated vessels over peripheral subplacental zone; for 3D Power Doppler: a) Numerous coherent vessels involving the entire uterine serosa-bladder junction (basal view); OR b) Hypervascularity (lateral view); OR c) Inseparable cotyledonal and intervillous circulations, chaotic branching, and detour vessels (lateral view); third, one of the following risk factors must be present: a) Prior cesarean delivery; OR b) Prior uterine surgery (including endometrial ablation); OR c) Cesarean scar pregnancy. Alternatively, Level 1 may be defined as morbidly adherent placentation found on histology in a hysterectomy or partial wedge resection specimen." + }, + { + "input": "Concept: anti-OX40 monoclonal antibody MOXR0916 (Immunologic Factor)", + "output": "Immunologic Factor described as an agonistic humanized monoclonal antibody against the receptor, OX40 (CD134), with potential immunostimulatory and antineoplastic activities. Upon intravenous administration, anti-OX40 monoclonal antibody MOXR0916 selectively binds to and activates OX40, by mimicking the action of endogenous OX40 ligand (OX40L). OX40 activation induces proliferation of effector T lymphocytes and inhibits the activity of regulatory T cells. In the presence of tumor-associated antigens (TAAs), this may promote an immune response against the TAA-expressing tumor cells. OX40, a cell surface glycoprotein and member of the tumor necrosis factor (TNF) receptor superfamily, is expressed on T lymphocytes and provides a co-stimulatory signal for the proliferation and survival of activated T cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C121376\" active clinical trials using this agent." + }, + { + "input": "Concept: xylitol oxidase activity (oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor)", + "output": "oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor described as catalysis of the reaction: xylitol + O2 = xylose + H2O2." + }, + { + "input": "Concept: Insertion (Introduction - action)", + "output": "Procedure categorized by device involved described as a surgical procedure that places something in the human body." + }, + { + "input": "Concept: spiritual well-being (Intellectual Product)", + "output": "something described as a question regarding the status of one's sense of meaning and purpose in life and ability to relate to their religious beliefs." + }, + { + "input": "Concept: ribonucleotide reductase (Iron-Sulfur Proteins)", + "output": "Protein or Riboprotein Complex described as interconverts ribonucleotides (RNA precursors) and deoxyribonucleotides (DNA precursors) rate limiting to DNA replication in rapidly dividing cells, and therefore a potential target of antineoplastic drugs." + }, + { + "input": "Concept: protein amino acid glycosylation in Golgi (Molecular Function)", + "output": "Molecular Function described as the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in any compartment of the Golgi apparatus." + }, + { + "input": "Concept: INTESTINAL VOLVULUS (gastrointestinal)", + "output": "Intestinal Volvulus described as twisting of a loop of bowel that results in intestinal obstruction." + }, + { + "input": "Concept: Grade 1 Blurred vision (Blurred Vision, CTCAE)", + "output": "Finding described as intervention not indicated" + }, + { + "input": "Concept: Storage Environment Temperature (Qualitative Concept)", + "output": "something described as storage requirements that are indicated for the device; environmental temperature range under which the device should be stored." + }, + { + "input": "Concept: Superfund Basic Research Program (Component of the National Institutes of Health)", + "output": "Health Care Related Organization described as a program of the National Institute of Environmental Health Sciences to create a network of university grants that are designed to seek solutions to the complex health and environmental issues associated with the nations hazardous waste sites." + }, + { + "input": "Concept: Surgical Procedures, Oral, Preprosthetic (Oral Surgical Procedures)", + "output": "Therapeutic or Preventive Procedure described as surgery necessary for a denture to rest on a firm base, free from marked osseous protuberances or undercuts, and devoid of interfering muscle attachments, excess mucoperiosteum, hyperplasias, and fibrous or papillary growths." + }, + { + "input": "Concept: human milk (Body Substance)", + "output": "Breast described as milk that is produced by HUMAN MAMMARY GLANDS." + }, + { + "input": "Concept: regulation of IP-10 production (regulation of chemokine production)", + "output": "regulation of chemokine production described as any process that modulates the frequency, rate, or extent of production of IP-10." + }, + { + "input": "Concept: Histone-Lysine N-Methyltransferase MLL/Gephyrin Fusion Protein (Fusion protein)", + "output": "something described as a fusion protein encoded by the MLL/GPHN fusion gene. This protein is comprised of the N-terminal half of the histone-lysine N-methyltransferase MLL protein, including the AT hook DNA binding domain and the DNA methyltransferase domain, fused with the C-terminus of the gephyrin protein including the presumed tubulin-binding site and a domain homologous to the E. coli molybdenum cofactor biosynthesis protein." + }, + { + "input": "Concept: Atherectomy Catheters (Angioplasty catheter)", + "output": "Medical Device described as angioplasty vascular catheters that permit the percutaneous transluminal removal of atherosclerotic plaque from the walls of arteries by mechanical means (e.g., cutting, drilling, pulverizing, shaving), resulting in a smooth vessel wall and little, if any, residual stenosis. Some of these catheters make possible the extraction of the atheromatous material from the arteries to the exterior." + }, + { + "input": "Concept: Extent of Problems Opening Mouth Wide (Clinical or Research Assessment Question)", + "output": "Clinical or Research Assessment Question described as a question about the extent to which an individual has or had problems opening their mouth wide." + }, + { + "input": "Concept: EMO1-Happiness Responded as Fear (Intellectual Product)", + "output": "Intellectual Product described as emotion Recognition Test (ERT) Number of happiness stimuli responded to as fear." + }, + { + "input": "Concept: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity (Molecular Function)", + "output": "transferase activity, transferring alkyl or aryl (other than methyl) groups described as catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate." + }, + { + "input": "Concept: Chronic diarrhoea with villous atrophy syndrome (Digestive system hereditary disorder)", + "output": "Disorder of mitochondrial respiratory chain complexes described as a rare genetic gastroenterological disease characterized by the early onset of chronic diarrhea, vomiting, anorexia, lactic acidosis, renal insufficiency and hepatic involvement (mild elevation of liver enzymes, steatosis, hepatomegaly). Partial villous atrophy (with eosinophilic infiltration) is observed on intestinal biopsy. Although diarrhea may resolve, the development of neurologic symptoms (cerebellar ataxia, sensorineural deafness, seizures), retinitis pigmentosa and muscle weakness may complicate disease course and lead to death. There have been no further descriptions in the literature since 1994." + }, + { + "input": "Concept: Non-Starch Polysaccharide (Organic Chemical)", + "output": "something described as the polymeric fraction of dietary fiber that includes all polysaccharides and excludes lignin and all starch. It is typically a mixture of cellulose, hemicellulose, pectins and gums (DRI)." + }, + { + "input": "Concept: Product.classCode (Intellectual Product)", + "output": "something described as a coded value specifying a group of products that are homogeneous or generally considered as substitutes for each other. The class is considered as narrow or broad depending on how substitutable the various products are." + }, + { + "input": "Concept: PODCI2-Gym Limited by: Dislike (Intellectual Product)", + "output": "Intellectual Product described as pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported - If you answered \"sometimes\" or \"never or rarely\" to Question 66 above, was your child's activity limited by: Dislike of gym/recess?" + }, + { + "input": "Concept: MIR432 Gene (MicroRNA Gene)", + "output": "MicroRNA Gene described as this gene is involved in the regulation of gene expression and plays a role in the development of epithelial ovarian carcinoma." + }, + { + "input": "Concept: phosphomethylpyrimidine kinase activity (kinase activity)", + "output": "phosphotransferase activity, phosphate group as acceptor described as catalysis of the reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine." + }, + { + "input": "Concept: EGSEQ (Intellectual Product)", + "output": "Intellectual Product described as an identifier that describes the relative position of electrocardiogram data within a series." + }, + { + "input": "Concept: supramolecular fiber organization (Cell Function)", + "output": "cellular component organization described as a process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure." + }, + { + "input": "Concept: 622 FAMILY CERATOPOGONIDAE - BITING MIDGES AND PUNKIES (Nematocera)", + "output": "Nematocera described as a family of biting midges, in the order DIPTERA. It includes the genus Culicoides which transmits filarial parasites pathogenic to man and other primates." + }, + { + "input": "Concept: Theraputic touch (Physical Comfort Promotion)", + "output": "Therapeutic or Preventive Procedure described as providing comfort and communication through purposeful tactile contact" + }, + { + "input": "Concept: boarding school (School)", + "output": "School described as elementary or secondary residential educational institutions for students enrolled in an instructional program. Primarily used for non-disordered populations." + }, + { + "input": "Concept: BCR101TN (CDISC Questionnaire Terminology)", + "output": "something described as borg CR10 scale test name." + }, + { + "input": "Concept: Sea Urchins (Sea urchin)", + "output": "Echinodermata described as somewhat flattened, globular echinoderms, having thin, brittle shells of calcareous plates. They are useful models for studying FERTILIZATION and EMBRYO DEVELOPMENT." + }, + { + "input": "Concept: TISSUE INHIBITOR 02 OF METALLOPROTEINASE (Tissue Inhibitor of Metalloproteinases)", + "output": "Tissue Inhibitor of Metalloproteinases described as a member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase A by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of TIMP-2 has been shown to inhibit invasive and metastatic activity of tumor cells and decrease tumor growth in vivo." + }, + { + "input": "Concept: Faulty Instrument or Use of Instrument Artifact (Finding)", + "output": "Finding described as an artifact resulting from the use of defective equipment or from improper use of equipment." + }, + { + "input": "Concept: supraglottic laryngectomy (Laryngectomy)", + "output": "something described as surgical removal of the portion of the larynx superior to the true vocal cords." + }, + { + "input": "Concept: MATRIX METALLOPROTEINASE 11 (Metallopeptidase Gene)", + "output": "Metallopeptidase Gene described as this gene plays a role in embryogenesis." + }, + { + "input": "Concept: Ribonucleoside, Cytosine (Nucleotides)", + "output": "Ribonucleosides described as a pyrimidine nucleoside comprised of a cytosine bound to ribose via a beta-N1-glycosidic bond. Cytidine is a precursor for uridine. Both cytidine and uridine are utilized in RNA synthesis." + }, + { + "input": "Concept: T Cell Immunoglobulin and Mucin Domain Containing Protein 1 (Membrane Glycoproteins)", + "output": "Amino Acid, Peptide, or Protein described as an Ig domain-containing membrane receptor for HEPATITIS A VIRUS; EBOLA VIRUS; MARBURG VIRUS; and DENGUE VIRUS. It may also function to modulate ASTHMA and HYPERSENSITIVITY." + }, + { + "input": "Concept: Hospital, General (Manufactured Object)", + "output": "Health Care Related Organization described as large hospitals with a resident medical staff which provides continuous care to maternity, surgical and medical patients." + }, + { + "input": "Concept: Extrahepatic Bile Duct Small Cell NEC (Carcinoma of extrahepatic bile duct)", + "output": "Extrahepatic Bile Duct Neuroendocrine Carcinoma described as an aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the extrahepatic bile ducts. It is characterized by the presence of malignant small cells." + }, + { + "input": "Concept: Diethylstilbestrol-containing product (Endocrine in tox)", + "output": "Contraceptive Agents, Female described as a synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen." + }, + { + "input": "Concept: postsynaptic actin cytoskeleton (Cell Component)", + "output": "postsynaptic cytoskeleton described as the actin cytoskeleton that is part of a postsynapse." + }, + { + "input": "Concept: Intraretinal exudate (Finding)", + "output": "Finding described as retinal exudate within the retinal tissue itself." + }, + { + "input": "Concept: Predatory aggression (Appetitive Behavior)", + "output": "MISCELLANEOUS BEHAVIOR STATES described as instinctual behavior pattern in which food is obtained by killing and consuming other animals." + }, + { + "input": "Concept: Stellate Cells, Pancreatic (Cells)", + "output": "Cells described as star-shaped, myofibroblast-like cells located in the periacinar, perivascular, and periductal regions of the EXOCRINE PANCREAS. They play a key role in the pathobiology of FIBROSIS; PANCREATITIS; and PANCREATIC CANCER." + }, + { + "input": "Concept: Blasts 20-30 Percent of Bone Marrow Nucleated Cells (Finding)", + "output": "something described as a semi-quantitative microscopic finding indicating that between 20 and 30 percent of the nucleated cells in a bone marrow sample are immature mononuclear cells." + }, + { + "input": "Concept: prolactin-releasing peptide receptor binding (Molecular Function)", + "output": "Molecular Function described as interacting selectively and non-covalently with a prolactin-releasing peptide receptor." + }, + { + "input": "Concept: borohydride (Chemical Viewed Structurally)", + "output": "something described as a class of inorganic or organic compounds that contain the borohydride (BH4-) anion." + }, + { + "input": "Concept: negative regulation of cap-independent translational initiation (negative regulation of cytoplasmic translational initiation)", + "output": "negative regulation of cytoplasmic translational initiation described as any process that stops, prevents or reduces the frequency, rate or extent of cap-independent translational initiation." + }, + { + "input": "Concept: CMENDAT (Temporal Concept)", + "output": "End date described as the stop date of the concomitant medication." + }, + { + "input": "Concept: material (Substance)", + "output": "Concept Attribute described as a physical substance or system. EXAMPLE(S): drugs such as aspirin devices such as pacemakers or freezers systems such as software programs biologics such as blood food products such as broccoli cosmetics such as lipstick containers such as a blister pack or a test tube OTHER NAME(S): NOTE(S): Materials may be naturally occurring or may be made by natural or engineered processes." + }, + { + "input": "Concept: I don't look like myself (Intellectual Product)", + "output": "Clinical or Research Assessment Question described as a question about whether an individual feels or felt like they don't look like themselves." + }, + { + "input": "Concept: MAXILLARY NEOPL (Neoplastic Process)", + "output": "Facial Neoplasms described as cancer or tumors of the MAXILLA or upper jaw." + }, + { + "input": "Concept: silicone (Organic silicon compound, NOS)", + "output": "Siloxanes described as a synthetic gel that is used as an outer coating on breast implants and as the inside filling of some implants." + }, + { + "input": "Concept: Judgement, NOS (Intellectual faculties)", + "output": "Intellectual faculties described as process of discovering or asserting an objective or intrinsic relation between two objects or concepts; a faculty or power that enables a person to make judgments; the process of bringing to light and asserting the implicit meaning of a concept; a critical evaluation of a person or situation." + }, + { + "input": "Concept: Cytomegalovirus Antigen Measurement (Microbiology procedure)", + "output": "Viral antigen assay described as the determination of the cytomegalovirus antigen present in a sample." + }, + { + "input": "Concept: heart innervation (Organ or Tissue Function)", + "output": "Autonomic nervous system described as nerve supply of the heart." + }, + { + "input": "Concept: Child-Pugh Clinical Classification (Research or Clinical Assessment Tool)", + "output": "Clinical Classification described as a standardized rating scale used to assess the severity of liver cirrhosis and determine the prognosis, the required strength of treatment, and the necessity of liver transplantation. This instrument uses the following clinical and lab criteria: encephalopathy grade, ascites, bilirubin, albumin, and prothrombin index." + }, + { + "input": "Concept: Increased bone density of end part of the long bone of hands (Ivory epiphyses)", + "output": "something described as sclerosis of the epiphyses of the metacarpals, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." + }, + { + "input": "Concept: H 2 Antigens (Histocompatibility Antigens Class II)", + "output": "Histocompatibility Antigens Class II described as the major group of transplantation antigens in the mouse." + }, + { + "input": "Concept: Glasgow coma score finding (Glasgow coma scale finding)", + "output": "Finding described as this is the original version, published in 1974. It has a maximum score of 14." + }, + { + "input": "Concept: Abiotrophia adiacens (Nutritionally variant streptococci)", + "output": "Bacterium described as any bacterial organism that can be assigned to the species Granulicatella adiacens." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, NF1 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation described as molecular assay reagents intended to identify mutations in the neurofibromin 1 (NF1) gene, located at chromosome 17q11.2, which encodes for the protein neurofibromin, produced in many cells, including nerve cells (oligodendrocytes and Schwann cells). Neurofibromin acts as a tumor suppressor protein. Mutations at this locus have identified in patients with neurofibromatosis 1 (von Recklinghausen's disease); it is also associated with related diseases including Watson syndrome." + }, + { + "input": "Concept: Oropharyngeal Cancer pNX TNM Finding (Finding)", + "output": "Oropharyngeal Cancer Pathologic Regional Lymph Nodes TNM Finding v6 described as oropharyngeal cancer in which the regional lymph nodes cannot be assessed." + }, + { + "input": "Concept: Frozen Sections (section sample)", + "output": "Tissue described as thinly cut sections of frozen tissue specimens prepared with a cryostat or freezing microtome." + }, + { + "input": "Concept: Pharmaceutical Dosage Form (Intellectual Product)", + "output": "Intellectual Product described as physical manifestation of a product that contains the active ingredient(s) and/or inactive ingredient(s) that are intended to be delivered to the patient. Note: 'Pharmaceutical dose form' and 'Dosage form' are synonyms. 'Pharmaceutical dose form' can refer to the administrable dose form or the manufactured dose form, depending on the product that it is describing." + }, + { + "input": "Concept: metallothioneins (Metalloproteins)", + "output": "Biologically Active Substance described as a family of cysteine-rich proteins that bind to and transport heavy metal ions." + }, + { + "input": "Concept: Dental retention pin (Implantable dental prosthesis, device)", + "output": "Dental Equipment and Supplies described as dental pins designed for insertion in the healthy dentine of a tooth to provide retention and/or stabilization (i.e., scaffolding) for dental restorations. These pins are typically small-diameter metal (e.g., stainless steel, titanium) cylinders, usually in a range of 1.0 to 3.2 mm (0.04 to 0.125 inch) that are inserted in a previously drilled hole in the tooth and fixed by either cement and/or threading or friction. A cylindrical hole with a beveled top is predrilled in the tooth to receive the threaded end of the pin; pins with a diameter larger than the accommodating hole may be fixed by friction alone. The upper part of the pin provides a surface for securely attaching the restoration (e.g., a reconstructed coronal portion) to the tooth. Larger devices intended for insertion into the root canal are called dental posts." + }, + { + "input": "Concept: ENTITY 5 (Geographic Area)", + "output": "something described as a geopolitical entity designated by the Geopolitical Entities, Names, anc Codes Standard (GENC)." + }, + { + "input": "Concept: MG1 Maraba/MAGE-A3 (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as a vaccine consisting of the attenuated, genetically-modified, oncolytic form of the Maraba virus, MG1, which has been engineered to express a gene encoding the cancer testis antigen melanoma antigen family A3 (MAGE-A3), with potential antineoplastic activity. Upon administration of genetically-modified MAGE-A3-expressing MG1 Maraba virus vaccine, the attenuated Maraba virus selectively and rapidly replicates in cancer cells; however, it is unable to replicate in normal, healthy cells. This induces a selective Maraba virus-mediated cytotoxicity in those cancer cells, and leads to cancer cell lysis. In addition, the expression of MAGE-A3 further stimulates the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing MAGE-A3. The tumor-associated antigen MAGE-A3 is overexpressed by a variety of cancer cell types. The attenuated virus is a double mutant strain with single amino acid substitutions occurring in both G protein (Q242R) and M protein (L123W)." + }, + { + "input": "Concept: AML02 (Intellectual Product)", + "output": "Intellectual Product described as the identifier AML02, assigned to a study in a clinical trial." + }, + { + "input": "Concept: SB (Intellectual Product)", + "output": "something described as a special purpose domain that associates the subject with the medical conclusions contained in the PB domain based on the observations reported in PF." + }, + { + "input": "Concept: Electronic Thermometers (Thermometer, device)", + "output": "Medical Device described as thermometers that include an electronic device and attached sensors that detect and transduce changes in temperature into variations of some electric characteristic (e.g., resistance, voltage). These variations of the electric characteristics are processed in electronic circuits and, in turn, displayed as temperature readings." + }, + { + "input": "Concept: DIF-1 3(5)-dechlorinase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the reaction: 1-[(3,5-dichloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one => 1-[(3-chloro-2,6-dihydroxy-4-methoxy)phenyl]hexan-1-one + Cl-." + }, + { + "input": "Concept: Selenomonas, NOS (Selenomonadaceae)", + "output": "Bacteroidaceae described as curved bacteria, usually crescent-shaped rods, with ends often tapered, occurring singly, in pairs, or short chains. They are non-encapsulated, non-sporing, motile, and ferment glucose. Selenomonas are found mainly in the human buccal cavity, the rumen of herbivores, and the cecum of pigs and several rodents." + }, + { + "input": "Concept: Nickel (dietary mineral)", + "output": "dietary mineral described as forms of the element nickel found in foods." + }, + { + "input": "Concept: Ineffective relationships (Role performance behavior)", + "output": "Role performance behavior described as a pattern of mutual partnership that is insufficient to provide for each other's needs." + }, + { + "input": "Concept: Chondrodysplasia Punctata (Stippled Epiphyses) Group (Osteochondrodysplasia with defects of growth of tubular bones and spine, unspecified)", + "output": "Chondrodysplasia Punctata described as a rare congenital developmental disorder characterized by the presence of stippled foci of calcification in the hyaline cartilage, joint contractions, mental retardation and ichthyosis." + }, + { + "input": "Concept: Disseminated lupus erythematosus (Systemic involvement of connective tissue, unspecified)", + "output": "Examiner's Diagnosis described as a chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes." + }, + { + "input": "Concept: 7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo(4,5-h)benzodiazepine (Central Nervous System Stimulants)", + "output": "Organic Chemical described as a substance that is being studied in the treatment of brain tumors and other brain disorders, such as epilepsy and Parkinson disease. It is a type of AMPA receptor antagonist." + }, + { + "input": "Concept: Left Ventricular Apical Inferior Segment (Body Part, Organ, or Organ Component)", + "output": "something described as the inferior portion of the apical division of the left ventricular myocardium as determined using the AHA 17-Segment Model (Cerqueira et al., 2002)." + }, + { + "input": "Concept: JCAR015 (Cell)", + "output": "Antineoplastic Immune Cell described as genetically modified CD3-positive-enriched autologous T-lymphocytes transduced with a replication incompetent gamma retroviral vector expressing a chimeric T-cell antigen receptor (CAR) consisting of an anti-CD19 single chain variable fragment (scFv), fused to the extracellular, transmembrane and intracellular signaling domains of the T-cell co-stimulatory receptor CD28 and the cytoplasmic signaling domain of the zeta chain of the TCR/CD3 complex (CD3-zeta) (CAR19-28z), with potential antineoplastic activities. Upon intravenous administration, vadacabtagene leraleucel,is directed to CD19-expressing tumor cells, and, upon binding to the T-cells, induce selective toxicity in CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. The CD28 co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19. The inclusion of the CD28 signaling domain may increase proliferation of T-cells and antitumor activity compared to the inclusion of the CD3-zeta chain alone." + }, + { + "input": "Concept: Loss of Immunohistochemical Expression of SDHB (SDHB Negative)", + "output": "SDHB Negative described as an immunohistochemical test result indicating the loss of expression of succinate dehydrogenase (SDH) B in the neoplastic cells of a tumor sample." + }, + { + "input": "Concept: PODCI3 (Intellectual Product)", + "output": "Clinical or Research Assessment Questionnaire described as a standardized 83-item self-report questionnaire, developed by the American Academy of Orthopaedic Surgeons and the Pediatric Orthopaedic Society of North America (POSNA) in 1998 to assess the overall health, pain, and ability to participate in normal daily activities in patients 11 to 18 years of age. The instrument includes five scales: upper extremity and physical function, transfer and mobility tasks, sports/physical functioning, pain/comfort, treatment expectations, happiness, and satisfaction with symptoms, as well as a Global Functioning scale that consists of the mean of the values for the first four scales." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, PYGM (Medical Device)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation described as molecular assay reagents intended to identify mutations in the muscle glycogen phosphorylase (PYGM) gene, located at chromosome 11q12-q13.2, which encodes for a protein that catalyzes the hydrolysis of intracellular glycogen. This genetic mutation has been identified in patients with hereditary glycogen storage disease type V (McArdle's disease)." + }, + { + "input": "Concept: Table, Partin (Quantitative Concept)", + "output": "something described as nomograms used for predicting the stages of PROSTATE CANCER. They are comprised of the serum PROSTATE-SPECIFIC ANTIGEN levels, the GLEASON SCORE, and the TNM STAGING category." + }, + { + "input": "Concept: Pipette Fillers, Safety (Medical Device)", + "output": "Pipette described as pipette fillers designed for safe use of pipettes when handling potentially hazardous liquids. These fillers consist of a rubber or plastic bulb with a small bulb derivation and several valves. The operation of the pipette includes squeezing the main bulb and the aspiration (A) valve simultaneously to produce a vacuum; squeezing the suction (S) valve until the liquid reaches the desired level; and squeezing the expel (E) valve allowing the liquid to flow out the pipette." + }, + { + "input": "Concept: Powder Funnels (Medical Device)", + "output": "something described as funnels used for quickly pouring powders between containers. Powder funnels can vary in size depending on use; they can be made of plastic, glass, or metal; and they have short and wide necks to facilitate funneling. Powder funnels are used in medical and/or chemical laboratories." + }, + { + "input": "Concept: homocysteine formation (Molecular Function)", + "output": "something described as the chemical reactions and pathways resulting in the formation of homocysteine, 2-amino-4-sulfanylbutanoic acid." + }, + { + "input": "Concept: O-glycan processing, core 2 (Molecular Function)", + "output": "something described as the stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 2 O-glycan structure, GlcNAc-beta-(1->6)[Gal-beta-(1->3)]-GalNAc." + }, + { + "input": "Concept: pyrimidine nucleoside breakdown (Molecular Function)", + "output": "Molecular Function described as the chemical reactions and pathways resulting in the breakdown of one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." + }, + { + "input": "Concept: Stanazolol Measurement (Laboratory Procedure)", + "output": "Laboratory Procedure described as the determination of the amount of stanazolol present in a sample." + }, + { + "input": "Concept: cell-cell junction assembly (Cell Function)", + "output": "Cell Function described as the aggregation, arrangement and bonding together of a set of components to form a junction between cells." + }, + { + "input": "Concept: Malignant Tumor of Endocrine Gland (Malignant neoplasms of thyroid and other endocrine glands)", + "output": "Endocrine System Diseases described as cancer that occurs in endocrine tissue, the tissue in the body that secretes hormones." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Hematology, Coagulation, Thrombosis Marker, Fibrinopeptide A (Medical Device)", + "output": "something described as hematology reagents intended to perform qualitative and/or quantitative analyses on a sample of body fluids (typically blood) to determine fibrinopeptide A, a product of the conversion of fibrinogen to fibrin monometer in the process of coagulation. Increased levels of fibrinopeptide A are used as markers of thrombosis; they provide specific data for early diagnosis and management of coagulation disorders." + }, + { + "input": "Concept: Vascular Near-Infrared Spectroscopy Laser Scanning Systems (Medical Device)", + "output": "Medical Device described as near-infrared spectroscopy (NIR spectroscopy) laser scanning systems designed to provide data and images showing the lipid composition of the inner layers of the vascular walls (i.e., intravascular). The light wavelength changes are detected and automatically analyzed to determine the absorption and changes in speed after the light passes across the tissue and is reflected back;, resulting in optical slice color images showing the chemical composition of the vascular wall tissue that can be viewed on a video display terminal. The system usually consists of a central computerized unit that includes the laser source, optical processors, analysis software, and a detachable intravascular dedicated fiberoptic catheter. Intravascular NIR spectroscopy systems are intended to assess the lipid content of artery (e.g., coronary) plaque to facilitate patient diagnosis and/or treatment." + }, + { + "input": "Concept: GH-secreting pituitary adenoma (Pituitary Neoplasms)", + "output": "Functioning pituitary neoplasm described as a pituitary tumor that secretes GROWTH HORMONE. In humans, excess HUMAN GROWTH HORMONE leads to ACROMEGALY." + }, + { + "input": "Concept: box C/D small nucleolar ribonucleoprotein complex assembly (Genetic Function)", + "output": "something described as the aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex." + }, + { + "input": "Concept: iota-carrageenase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the endohydrolysis of 1,4-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose-2-sulfate in iota-carrageenans." + }, + { + "input": "Concept: AUC %Back Extrapolation Obs (Area Under Curve)", + "output": "something described as applies only for intravascular bolus dosing. The area under the curve (AUC) from the first measured concentration value back extrapolated to the concentration value at time zero as a percentage of the area under the curve extrapolated to infinity using the observed value of the last non-zero concentration." + }, + { + "input": "Concept: response to glucitol (response to carbohydrate)", + "output": "something described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus." + }, + { + "input": "Concept: Particle Sizing, Other (Particle Size)", + "output": "Laboratory Procedure described as any other particle sizing operation not elsewhere described." + }, + { + "input": "Concept: Aranea scinencia / gray spider (Organic Chemical)", + "output": "something described as gray spider." + }, + { + "input": "Concept: down-regulation of excitatory synapse disassembly (regulation of excitatory synapse pruning)", + "output": "regulation of excitatory synapse pruning described as any process that stops, prevents or reduces the frequency, rate or extent of excitatory synapse pruning." + }, + { + "input": "Concept: Determinations, Endpoint (Biological Assay)", + "output": "something described as establishment of the level of a quantifiable effect indicative of a biologic process. The evaluation is frequently to detect the degree of toxic or therapeutic effect." + }, + { + "input": "Concept: Optical Fiber Device (Device Component or Accessory)", + "output": "Fiber Device described as a device made with thin glass fibers as a conduit for transmission of light." + }, + { + "input": "Concept: Pregnatrienes (Pregnanes)", + "output": "something described as pregnane derivatives containing three double bonds in the ring structures." + }, + { + "input": "Concept: International Unit/Gram (Quantitative Concept)", + "output": "Quantitative Concept described as a unit of measure of quantity of substance per unit mass, expressed in terms of the International Unit per grams." + }, + { + "input": "Concept: LIPRIN-BETA-1 (Gene or Genome)", + "output": "something described as this gene plays a role in protein-protein interactions and cell-matrix adhesion." + }, + { + "input": "Concept: small interfering RNA binding (Genetic Function)", + "output": "regulatory RNA binding described as interacting selectively and non-covalently with a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme." + }, + { + "input": "Concept: Levotetramisole (Drug allergens)", + "output": "Immunomodulators described as an anthelmintic drug. Co-administered with fluorouracil in the treatment of Dukes' stage C colon cancer, levamisole restores immune function through stimulating antibody formation, enhancing T-cell activity, and potentiating macrophage function." + }, + { + "input": "Concept: indole-3-acetyl-glycine synthetase activity (ligase activity, forming carbon-nitrogen bonds)", + "output": "Molecular Function described as catalysis of the reaction: indole-3-acetate + glycine + ATP(4-) <=> H+ + indole-3-acetyl-glycine + AMP(2-) + diphosphoric acid." + }, + { + "input": "Concept: AML Subject ID (Intellectual Product)", + "output": "Intellectual Product described as the subject identifier assigned by the acute myeloid leukemia project within the pediatric cancer data commons terminology." + }, + { + "input": "Concept: CMT4A (Charcot-Marie-Tooth disease type 4)", + "output": "something described as charcot-Marie-Tooth disease type 4A (CMT4A) is a severe, early-onset form of demyelinating Charcot-Marie-Tooth peripheral sensorimotor polyneuropathy with manifestation of severe motor retardation and progressive scoliosis. Considered the most frequent of all autosomal recessive forms of CMT. Onset usually occurs in infancy with distal muscle weakness and foot atrophy followed by proximal involvement and then distal weakness in the upper extremities and atrophy of the hands. Vocal cord paresis may also occur. CMT4A is caused by mutations in the GDAP1 gene (8q13.3), encoding a protein required for mitochondrial fission. Transmitted in an autosomal recessive manner." + }, + { + "input": "Concept: DNA-REAGENTS, NEISSERIA (Indicator, Reagent, or Diagnostic Aid)", + "output": "something described as neisseria spp. direct serological test reagents are devices that consist of antigens and antisera used in serological tests to identify Neisseria spp. from cultured isolates. Additionally, some of these reagents consist of Neisseria spp. antisera conjugated with a fluorescent dye (immunofluorescent reagents) which may be used to detect the presence of Neisseria spp. directly from clinical specimens. The identification aids in the diagnosis of disease caused by bacteria belonging to the genus Neisseria, such as epidemic cerebrospinal meningitis, meningococcal disease, and gonorrhea, and also provides epidemiological information on diseases caused by these microorganisms. The device does not include products for the detection of gonorrhea in humans by indirect methods, such as detection of antibodies or of oxidase produced by gonococcal organisms." + }, + { + "input": "Concept: Lipoprotein apolipoprotein, NOS (Apoproteins)", + "output": "Biologically Active Substance described as protein components of lipoproteins which remain after the lipids to which the proteins are bound have been removed; they play an important role in lipid transport and metabolism." + }, + { + "input": "Concept: Urachal remnant (Congenital Abnormality)", + "output": "something described as remaining collapsed and obliterated urachal tissue between the bladder dome and umbilicus." + }, + { + "input": "Concept: Upper abdomen (Anterior abdominal surface region)", + "output": "Body Location or Region described as the superior portion of the abdomen." + }, + { + "input": "Concept: NADPH dehydrogenase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor." + }, + { + "input": "Concept: I Can Call This Doctor if I Have Concern and am Not Sure I Need to See a Doctor (Clinical or Research Assessment Question)", + "output": "something described as a question about whether an individual can call a particular doctor if they have a concern and are not sure they need to see a doctor." + }, + { + "input": "Concept: COWS1-Resting Pulse Rate (COWS Questionnaire Question)", + "output": "COWS Questionnaire Question described as clinical Opiate Withdrawal Scale - Resting pulse rate." + }, + { + "input": "Concept: IVD Panels, Human Genetics, Rasopathies, Neurofibromatosis Syndrome, Mutation (IVD Panels, Human Genetics, Rasopathies, Neurofibromatosis Syndrome)", + "output": "Medical Device described as molecular assay reagents intended to identify mutations in genes associated with neurofibromatosis, a collection of genetic disorders characterized by the formation of tumors in the nervous system. Genetic variants at multiple loci have been associated with neurofibromatosis. These reagents are intended to detect mutations in multiple neurofibromatosis-associated loci simultaneously." + }, + { + "input": "Concept: Lower Lip (Lip structure)", + "output": "Body Part, Organ, or Organ Component described as the lip that covers the anterior portion of the mandible." + }, + { + "input": "Concept: IMP metabolism (purine ribonucleoside monophosphate metabolic process)", + "output": "Molecular Function described as the chemical reactions and pathways involving IMP, inosine monophosphate." + }, + { + "input": "Concept: BB 21217 (Cell)", + "output": "Cell described as a preparation of autologous memory T lymphocytes transduced, ex vivo, with a lentiviral vector expressing a chimeric antigen receptor (CAR) containing an anti-B-cell maturation antigen (BCMA) single chain variable fragment (scFv) fused to the signaling domain of 4-1BB (CD137) and a CD3-zeta T-cell activation domain, with potential immunostimulating and antineoplastic activities. Upon intravenous administration back into the patient, the autologous anti-BCMA-CAR-4-1BB-CD3zeta-expressing memory T lymphocytes bb21217 are directed to, and induce selective toxicity in, BCMA-expressing tumor cells. BCMA, a tumor specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and plays a key role in plasma survival. BCMA is overexpressed on malignant plasma cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C140310\" active clinical trials using this agent." + }, + { + "input": "Concept: Granulomatous lesion (Granulomatous and deep cutaneous inflammatory conditions)", + "output": "Lymphoproliferative Disorders described as a lesion characterized by the presence of epithelioid histiocytes and chronic inflammation." + }, + { + "input": "Concept: Hyperviscosity (Laboratory test result abnormal)", + "output": "Finding of substance level described as an increase in the viscosity of blood resulting from an increase in the proportion of cellular elements of the blood, a change in the mechanical properties of the cellular elements of the blood, and/or an alteration in plasma viscosity." + }, + { + "input": "Concept: IFNAR2.1 Subunit, Interferon alpha-beta Receptor (Amino Acid, Peptide, or Protein)", + "output": "something described as a shortened cytoplasmic domain variant of the IFNAR2 chain." + }, + { + "input": "Concept: SHC2 gene (Adaptor Signaling Protein Gene)", + "output": "something described as this gene is involved in signal transduction and protein binding." + }, + { + "input": "Concept: N4BP2 protein, human (Amino Acid, Peptide, or Protein)", + "output": "deoxyribonucleases described as NEDD4-binding protein 2 (1770 aa, ~199 kDa) is encoded by the human N4BP2 gene. This protein plays a role in DNA modification." + }, + { + "input": "Concept: 6-phosphoglucan, water dikinase activity (phosphotransferase activity, paired acceptors)", + "output": "phosphotransferase activity, paired acceptors described as catalysis of the reaction: n ATP + n H2O + a 6-phosphogluco-maltodextrin = n AMP + n hydrogenphosphate + a poly-6-phosphogluco-maltodextrin." + }, + { + "input": "Concept: Adverse Event Related to Commutability (Device Evaluation Conclusion)", + "output": "something described as the adverse event occurred because the material being used to calibrate or assess IVD performance did not have similar properties to those of human samples, leading to inappropriate bias and erroneous results. Examples of materials include: reference materials, calibrators, proficiency testing samples." + }, + { + "input": "Concept: FAMS0147 (Intellectual Product)", + "output": "FAMS Questionnaire Question described as functional Assessment of Multiple Sclerosis (FAMS) Additional Concerns: I feel close to my partner (or the person who is my main support)." + }, + { + "input": "Concept: Cultural Pluralism (Idea or Concept)", + "output": "something described as the presence of multiple value systems within or among societies." + }, + { + "input": "Concept: Subglottic Cancer pN1 TNM Finding (Finding)", + "output": "Finding described as subglottic cancer with metastasis to a single ipsilateral lymph node, 3 cm or less in greatest dimension." + }, + { + "input": "Concept: Epithelioid fibrous histiocytoma (Histiocytoma, Benign Fibrous)", + "output": "Histiocytoma, Benign Fibrous described as a morphologic variant of cutaneous fibrous histiocytoma characterized by the presence of epitheloid fibrohistiocytic cells." + }, + { + "input": "Concept: Skin autograft NOS (Skin graft material)", + "output": "Skin graft material described as an autograft is when the skin donor and the graft recipient are the same individual." + }, + { + "input": "Concept: 4-hydroxycatechol 1,2-dioxygenase activity (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)", + "output": "Molecular Function described as catalysis of the reaction: O2 + benzene-1,2,4-triol = maleylacetate." + }, + { + "input": "Concept: Beta-NGF Measurement (Protein or Enzyme Type Measurement)", + "output": "Laboratory Procedure described as the determination of the amount of nerve growth factor in a biological sample." + }, + { + "input": "Concept: Grade 1 Laryngeal stenosis (Finding)", + "output": "Laryngeal Stenosis, CTCAE described as asymptomatic; clinical or diagnostic observations only; intervention not indicated" + }, + { + "input": "Concept: protocatechuate catabolism (monocarboxylic acid catabolic process)", + "output": "something described as the chemical reactions and pathways resulting in the breakdown of 3,4-dihydroxybenzoate." + }, + { + "input": "Concept: Cytoskeletal Organization Process (Cell Function)", + "output": "Cell Function described as subcellular biological functions, activities, or processes that generate, maintain, or modify macromolecular cytoskeletal components." + }, + { + "input": "Concept: response to alcohol (response to organic substance)", + "output": "Cell Function described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus." + }, + { + "input": "Concept: Social Work (Occupation or Discipline)", + "output": "something described as the use of community resources, individual case work, or group work to promote the adaptive capacities of individuals in relation to their social and economic environments. It includes social service agencies." + }, + { + "input": "Concept: D-lactic acid dehydrogenase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the reaction: (R)-lactate + NAD(+) = H(+) + NADH + pyruvate." + }, + { + "input": "Concept: Effector Immune Cell (Immunologic cell)", + "output": "Leukocytes described as a cell that performs a specific function in response to a stimulus; usually used to describe cells in the immune system." + }, + { + "input": "Concept: Abnormality of the 4th long bone of hand (Anatomical Abnormality)", + "output": "Anatomical Abnormality described as any abnormality of the fourth metacarpal bone." + }, + { + "input": "Concept: Product containing temozolomide (Alkylating Agents)", + "output": "Other alkylating agents in ATC described as a drug that is used to treat certain types of brain tumors in adults and is being studied in the treatment of other types of cancer. It belongs to the family of drugs called alkylating agents." + }, + { + "input": "Concept: Biochemical Energetics (Biomedical Occupation or Discipline)", + "output": "Biomedical Occupation or Discipline described as the study of the energy changes involved in physical and chemical reaction, changes, and systems of living organisms." + }, + { + "input": "Concept: cargo loading into COPII-coated vesicle (Intracellular Transport)", + "output": "Intracellular Transport described as the formation of a macromolecular complex between the COPII coat proteins and proteins and/or lipoproteins that are going to be transported by the COPII vesicle to the Golgi." + }, + { + "input": "Concept: Grade 4 Disseminated Intravascular Coagulation, CTCAE (Disseminated Intravascular Coagulation, CTCAE)", + "output": "something described as life-threatening consequences; urgent intervention indicated" + }, + { + "input": "Concept: Casearia Jacq., 1760 (Samydeae)", + "output": "Plant described as a plant genus of the family SALICACEAE. Members contain casearins which are clerodane-type DITERPENES." + }, + { + "input": "Concept: Conditioning, Classical (Mental Process)", + "output": "something described as learning by associating a stimulus (the cause) with a particular outcome (the effect)." + }, + { + "input": "Concept: Scrotal Hemangioma (Benign neoplasm of scrotum)", + "output": "something described as a hemangioma arising from the skin of the scrotum." + }, + { + "input": "Concept: Biopsy, Liquid (Diagnostic Procedure)", + "output": "something described as obtaining material for pathological examination and analysis, from bodily fluids. Material retrieved includes CELL-FREE NUCLEIC ACIDS; CELL-DERIVED MICROPARTICLES; EXOSOMES; CIRCULATING NEOPLASM CELLS; and other circulating cells and CELLULAR STRUCTURES." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, APC (Medical Device)", + "output": "something described as molecular assay reagents intended to identify deletions or duplications of the adenomatous polyposis coli (APC) gene, located at chromosome 5q21-q22, which encodes the adenomatous polyposis coli protein. Genetic variants at this locus have been associated with familial adenomatous polyposis 1, hepatocellular carcinoma, hereditary desmoid disease, carcinoma of the colon, and neoplasm of the stomach." + }, + { + "input": "Concept: Calibration Date (Finding)", + "output": "something described as the date of the most recent calibration event for an instrument." + }, + { + "input": "Concept: Mallophaga (Eukaryote)", + "output": "Eukaryote described as a suborder of chewing lice, in the order PHTHIRAPTERA, that are ectoparasites of poultry and some mammals." + }, + { + "input": "Concept: Grade 2 Enterocolitis, CTCAE (Enterocolitis, CTCAE)", + "output": "Finding described as abdominal pain; mucus or blood in stool" + }, + { + "input": "Concept: placenta; previa (Physical Regulation Component)", + "output": "Congenital anomaly of genital system described as a condition in which the placenta is located over or near the internal os of the cervix, increasing the risk of haemorrhage." + }, + { + "input": "Concept: Wide fontanels (Size of fontanelle - finding)", + "output": "Abnormality of fontanelles described as in newborns, the two frontal bones, two parietal bones, and one occipital bone are joined by fibrous sutures, which form a small posterior fontanelle, and a larger, diamond-shaped anterior fontanelle. These regions allow for the skull to pass the birth canal and for later growth. The fontanelles gradually ossify, whereby the posterior fontanelle usually closes by eight weeks and the anterior fontanelle by the 9th to 16th month of age. Large fontanelles are diagnosed if the fontanelles are larger than age-dependent norms." + }, + { + "input": "Concept: Uterine Corpus Adenosarcoma pNX TNM Finding v8 (Finding)", + "output": "something described as uterine corpus adenosarcoma in which the regional lymph nodes cannot be assessed." + }, + { + "input": "Concept: 2-Acetamido-3-O-((((1S)-1-(((1R)-1-carbamoyl-3- carboxypropyl)carbamoyl)ethyl)carbamoyl)methyl)-2-deoxy-D- glucopyranose (ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS)", + "output": "something described as a synthetic muramyl dipeptide (MDP) H8analogue with potential immunostimulating and antineoplastic activity. As a derivative of the mycobacterial cell wall component MDP, almurtide activates both monocytes and macrophages. This results in the secretion of cytokines and induces the recruitment and activation of other immune cells, which may result in indirect tumoricidal or cytostatic effects. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C81667\" active clinical trials using this agent." + }, + { + "input": "Concept: CDISC SDTM Morphology Test Name Terminology (Intellectual Product)", + "output": "Unused Subset Concept described as terminology associated with the morphology test name codelist of the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: XmAb5574 (Antineoplastic Antibody)", + "output": "something described as an Fc engineered, humanized anti-CD19 monoclonal antibody directed against the B-cell-specific membrane protein CD19 with potential immunostimulating and antineoplastic activities. Anti-CD19 monoclonal antibody XmAb5574 targets and binds to CD19, thereby depleting and eliminating CD19-expressing B-cells. The modified Fc region of XmAb5574 increases binding affinity to Fc-gamma receptors of effector cells and thereby enhances antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cell-mediated phagocytosis (ADCP). CD19 is widely expressed during B-cell development, from pro-B-cell to early plasma cell stages." + }, + { + "input": "Concept: Refractory Anemia with Excess Blasts in Transformation (Refractory anemia, without ringed sideroblasts, without excess blasts)", + "output": "Hematopoietic and Lymphoid Neoplasm described as refractory anemia with excess blasts in transformation (RAEB-T) is characterised by dysplastic features of the myeloid and usually erythroid progenitor cells in the bone marrow and an increased number of myeloblasts in the peripheral blood. The peripheral blood blast count ranges from 20% to 30%. RAEB-T used to be a subcategory of myelodysplastic syndromes in the past. Recently, the term has been eliminated from the WHO based classification of myelodysplastic syndromes. The reason is that the percentage of peripheral blood blasts required for the diagnosis of acute myeloid leukemia has been reduced to 20%. The elimination of the RAEB-T term by the WHO experts has created confusion and ongoing arguments. Currently, according to WHO classification, the vast majority of RAEB-T cases are best classified as acute leukemias (acute leukemias with multilineage dysplasia following myelodysplastic syndrome). A minority of cases are part of RAEB-2." + }, + { + "input": "Concept: nucleoside transmembrane transporter activity, down a concentration gradient (nucleoside transmembrane transporter activity)", + "output": "nucleoside transmembrane transporter activity described as enables the transfer of a nucleoside, from one side of a membrane to the other, down the concentration gradient." + }, + { + "input": "Concept: Idiopathic thrombocytopenic purpura (Disorder of hematopoietic structure)", + "output": "Primary thrombocytopenia described as a condition in which platelets (blood cells that cause blood clots to form) are destroyed by the immune system. The low platelet count causes easy bruising and bleeding, which may be seen as purple areas in the skin, mucous membranes, and outer linings of organs." + }, + { + "input": "Concept: Rickettsia weigli (Bartonella species)", + "output": "something described as a species of Gram-negative, rod shaped bacteria assigned to the phylum Proteobacteria. This species is nonmotile, oxidase positive, indole and urease negative, and nonhemolytic. B. quintana causes trench fever." + }, + { + "input": "Concept: down regulation of intraciliary anterograde transport (negative regulation of intracellular protein transport)", + "output": "negative regulation of intracellular protein transport described as any process that stops, prevents or reduces the frequency, rate or extent of intraciliary anterograde transport." + }, + { + "input": "Concept: isocitrate dehydrogenase complex location (Cell Component)", + "output": "something described as complex that possesses isocitrate dehydrogenase (NAD+) activity." + }, + { + "input": "Concept: Lung Cancer pN1 TNM Finding v8 (Lung Cancer Pathologic Regional Lymph Nodes TNM Finding v8)", + "output": "something described as lung cancer with metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary nodes, including involvement by direct extension." + }, + { + "input": "Concept: cyclin B3-CDK2 complex location (Cell Component)", + "output": "Cell Component described as a protein complex consisting of cyclin B3 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." + }, + { + "input": "Concept: Web Service Definition Language (Intellectual Product)", + "output": "something described as an XML format for describing network services as a set of endpoints operating on messages containing either document-oriented or procedure-oriented information." + }, + { + "input": "Concept: FZD3 wt Allele (FZD3 gene)", + "output": "something described as human FZD3 wild-type allele is located within 8p21 and is approximately 70 kb in length. This allele, which encodes frizzled-3 protein, plays a role in signal transduction processes in the beta-catenin canonical signaling pathway." + }, + { + "input": "Concept: Restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature, e.g., light house work, office work (Finding)", + "output": "Finding described as based on an ECOG score of 1" + }, + { + "input": "Concept: Syringes, Plunger, Prefilled, Blood Volume Tracer, Luer Lock (Syringes, Plunger, Prefilled)", + "output": "Medical Device described as pre-filled, small (e.g., 1 mL), and calibrated syringes that end in a Luer lock tip and that are supplied filled with a saline solution containing a specific blood albumin tracer (e.g., iodine isotope 131, I131). These syringes are specially designed (sometimes with a stop cock instead of a plunger) to inject an accurate dose of several microcuries (typically 10 to 25) through an intravenous line; they are used for blood and blood component (e.g., red cells, plasma) volume measuring from blood samples taken after the tracer injection using a semi-automated or automated analyzer." + }, + { + "input": "Concept: rhombomere 4 development (rhombomere development)", + "output": "something described as the process whose specific outcome is the progression of rhombomere 4 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." + }, + { + "input": "Concept: Anthoceros (Plant)", + "output": "Plant described as a plant genus of the family Anthocerotaceae, order Anthocerotales, class Anthocerotopsida." + }, + { + "input": "Concept: Tissieria (Anaerobic non-sporing Gram-positive bacillus)", + "output": "Bifidobacterium described as a rod-shaped, gram-positive, non-acid-fast, non-spore-forming, non-motile bacterium that is a genus of the family Bifidobacteriaceae, order Bifidobacteriales, class ACTINOBACTERIA. It inhabits the intestines and feces of humans as well as the human vagina." + }, + { + "input": "Concept: Personnel (Persons)", + "output": "Workers described as a researcher in a study who oversees multiple aspects of the study, such as concept development, protocol writing, protocol submission for IRB approval, participant recruitment, informed consent, data collection, analysis, interpretation and presentation." + }, + { + "input": "Concept: GRAN EFFRV (Oral Granules)", + "output": "Granules dose form described as a granule composed of active and/or inert ingredient(s), and a mixture of acids and sodium bicarbonate, which release carbon dioxide when dissolved in water." + }, + { + "input": "Concept: striated muscle cell development (Cell Function)", + "output": "something described as the process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." + }, + { + "input": "Concept: ZNF793 wt Allele (Gene or Genome)", + "output": "ZNF793 gene described as human ZNF793 wild-type allele is located in the vicinity of 19q13.12 and is approximately 42 kb in length. This allele, which encodes zinc finger protein 793, may be involved in the regulation of transcription." + }, + { + "input": "Concept: alphaV-beta8 integrin-MMP14-TGFbeta-1 complex location (plasma membrane protein complex)", + "output": "Cell Component described as a protein complex that consists of an alphaV-beta8 integrin complex bound to matrix metalloproteinase 14 and transforming growth factor beta-1 (TGFbeta-1)." + }, + { + "input": "Concept: Stabilize Extremity Dislocation (Therapeutic or Preventive Procedure)", + "output": "Fracture Fixation described as immobilization of a dislocated extremity." + }, + { + "input": "Concept: Inosine dialdehyde (Purine antagonist)", + "output": "Organic Chemical described as a toxic purine analogue. Inosine dialdehyde inhibits ribonucleotide reductase, resulting in decreased synthesis of DNA, RNA, and proteins, and G2/M-phase cell cycle arrest. This agent also forms stable covalent crosslinks in proteins, thereby inhibiting the activity of enzymes involved in nucleic acid synthesis." + }, + { + "input": "Concept: CURETTE, SUCTION, ENDOMETRIAL (Medical Device)", + "output": "Medical Device described as an endometrial suction curette is a device used to remove material from the uterus and from the mucosal lining of the uterus by scraping and vacuum suction. This device is used to obtain tissue for biopsy or for menstrual extraction. This generic type of device may include catheters, syringes, and tissue filters or traps." + }, + { + "input": "Concept: Nutrigenomics (Biomedical Occupation or Discipline)", + "output": "Genomics described as the study of the relationship between NUTRITIONAL PHYSIOLOGY and genetic makeup. It includes the effect of different food components on GENE EXPRESSION and how variations in GENES effect responses to food components." + }, + { + "input": "Concept: trn (Cell Component)", + "output": "craniospinal nerves described as one of two nerves forming the vomeronasal-terminalis nerve complex from the lining of the nasal cavity to the brain. It is found in the rat ( Swanson-2004 ) and certain other animals ( Crosby-1962 ). Reports agree that the complex is demonstrable in the human fetus into the third trimester of gestation. They differ, however, as to whether it persists in the human beyond birth. Early authors said 'yes' ( Crosby-1962 ); later authors say 'no' ( Moran-1995 ). \\r\\nThe other component of the complex is the vomeronasal nerve. The two are located in close proximity throughout much of their course, but arise from different parts of the nasal epithelium and connect to somewhat different areas in the brain. They are distinct from the olfactory nerve, which is found in both rodents and primates." + }, + { + "input": "Concept: recesses of third ventricle (Body Space or Junction)", + "output": "something described as substructures of the third ventricle. They include the infundibular recess, the suprapineal recess, the pineal recess and the optic recess in primates ( Carpenter-1983 ) and the mammillary recess in rodents ( Paxinos-2001; Swanson-1998 )." + }, + { + "input": "Concept: Reporter Genes (Structural gene)", + "output": "Miscellaneous Molecular Biology Terms described as a gene which produces an easily assayed phenotype. Often used for expression studies of heterologous promoters." + }, + { + "input": "Concept: Gallbladder cancer (Neoplastic Process)", + "output": "Stage II Gallbladder Cancer AJCC v8 described as stage IIB includes: T2b, N0, M0. T2b: Tumor invading the perimuscular connective tissue on the hepatic side, with no extension into the liver. N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C134671\" active clinical trials using this agent." + }, + { + "input": "Concept: Stage I Thyroid Gland Papillary Cancer Under 55 Years (Stage I Thyroid Gland Papillary Carcinoma AJCC v8)", + "output": "Neoplastic Process described as stage I includes: Any T, Any N, M0. M0: No distant metastasis." + }, + { + "input": "Concept: xanthosine catabolism (purine ribonucleoside catabolic process)", + "output": "purine ribonucleoside catabolic process described as the chemical reactions and pathways resulting in the breakdown of xanthosine." + }, + { + "input": "Concept: WHODAS 2.0 12-item Version Interviewer-administered - Your Day-to-Day Work or School (Intellectual Product)", + "output": "something described as world Health Organization Disability Assessment Schedule 2.0 12-item Version Interviewer-administered (WHODAS 2.0 12-item Version Interviewer-administered) In the past 30 days, how much difficulty did you have in: Your day-to-day work/school?" + }, + { + "input": "Concept: Dextran, 2-(diethylamino)ethyl ether (Organic Chemical)", + "output": "Indicator, Reagent, or Diagnostic Aid described as used as a support for ion-exchange chromatography." + }, + { + "input": "Concept: phytol (Biologically Active Substance)", + "output": "Diterpenes described as a chemical substance that comes from plants and is used to make vitamins E and K. Phytol is also found in soaps, beauty care products, and household products." + }, + { + "input": "Concept: TSG101 (Biologically Active Substance)", + "output": "Regulatory Protein described as tumor susceptibility gene 101 protein (390 aa, ~44 kDa) is encoded by the human TSG101 gene. This protein is involved in both the binding and transport of ubiquitinated proteins." + }, + { + "input": "Concept: Tearing pain (Sign or Symptom)", + "output": "Pain described as an intense sensation of discomfort or distress that feels like being torn or ripped apart." + }, + { + "input": "Concept: Product containing edoxaban (Thiazoles)", + "output": "something described as an orally active inhibitor of coagulation factor Xa (activated factor X) with anticoagulant activity. Edoxaban is administered as edoxaban tosylate. This agent has an elimination half-life of 9-11 hours and undergoes renal excretion." + }, + { + "input": "Concept: down-regulation of striated muscle cell differentiation (Cell Function)", + "output": "something described as any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation." + }, + { + "input": "Concept: cellular response to UV light stimulus (response to UV)", + "output": "cellular response to light stimulus described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." + }, + { + "input": "Concept: Alprostadil product (alprostadil)", + "output": "Prostaglandins E described as a drug that is used to treat impotence (inability to have an erection) and is being studied in the treatment of sexual problems in men who have had surgery for prostate cancer. It is a type of vasodilator." + }, + { + "input": "Concept: Lateral division of spinal cord segment of corticospinal tract (Spinal cord, roots and ganglia structure)", + "output": "Spinal cord part described as an oval shaped area within the corticospinal tract that runs the entire length of the spinal cord just medial to the posterior spinocerebellar tract and contains motor nerve fibers originating from the opposite cerebral hemisphere." + }, + { + "input": "Concept: anaplastic childhood oligodendroglioma (Malignant Childhood Central Nervous System Neoplasm)", + "output": "something described as an anaplastic oligodendroglioma that occurs during childhood." + }, + { + "input": "Concept: negative regulation of brood size (regulation of brood size)", + "output": "regulation of brood size described as any process that decreases brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time." + }, + { + "input": "Concept: Leptomeninges, NOS (Meninges part)", + "output": "Region of leptomeningeal sac described as the two innermost layers of tissue that cover the brain and spinal cord, the arachnoid mater and the pia mater." + }, + { + "input": "Concept: neurobiology (biology)", + "output": "Neuroscience discipline described as biology of the nervous system. Used for the scientific discipline or the neurobiological processes themselves." + }, + { + "input": "Concept: Transcription Factor COE4 (Amino Acid, Peptide, or Protein)", + "output": "Biologically Active Substance described as transcription factor COE4 (602 aa, ~64 kDa) is encoded by the human EBF4 gene. This protein is involved in transcriptional regulation, B-cell maturation and neural development." + }, + { + "input": "Concept: NK Cell Lectin-Like Receptor Subfamily B (CD Antigens)", + "output": "something described as a subclass of NK cell lectin-like receptors that includes both inhibitory and stimulatory members." + }, + { + "input": "Concept: Upper respiratory tract structure (Respiratory system subdivision)", + "output": "Respiratory System described as subdivision of respiratory system which consists of the nose, nasopharynx, oropharynx and larynx" + }, + { + "input": "Concept: Thiamine phosphate (thiamine)", + "output": "something described as thiamine dihydrogen phosphate ester. The monophosphate ester of thiamine. Synonyms: monophosphothiamine; vitamin B1 monophosphate." + }, + { + "input": "Concept: Cocculine Extract (Pharmacologic Substance)", + "output": "something described as a homeopathic herbal formulation with potential anti-emetic activity. Cocculus/nux vomica/tabacum/petroleum extract contains equal homeopathic units of the following extracts: extract of Cocculus indicus (fish berry), the fruit of the southeast Asian/Indian climbing plant Anamirta cocculus; extract of the seeds of Strychnos nux vomica (poison nut), an evergreen tree native to southeast Asia; extract of Nicotiana tabacum (tobacco); and petroleum. Although the exact mechanism(s) of action for this formulation has yet to be fully elucidated, alkaloids in these plant extracts have been shown to relieve nausea, vomiting, and, in some cases, dizziness. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C66805\" active clinical trials using this agent." + }, + { + "input": "Concept: PHQ0302I (PHQ Screener Version Questionnaire Question)", + "output": "something described as patient Health Questionnaire Screener Version (PHQ Screener Version) Over the last 2 weeks, how often have you been bothered by thoughts that you would be better off dead or of hurting yourself in some way?" + }, + { + "input": "Concept: Small toe (Finding)", + "output": "Aplasia/Hypoplasia of toe described as significant reduction in both length and girth of the toe compared to the contralateral toe, or alternatively, compared to a typical toe size for an age-matched individual." + }, + { + "input": "Concept: Parasitism, NOS (General Body States, Conditions and Activities)", + "output": "something described as intimate relationship between organisms of two or more kinds, particularly one in which the symbiont benefits from the host. Includes parasitic behavior. Limited to animal populations." + }, + { + "input": "Concept: TPN (Nucleic Acid, Nucleoside, or Nucleotide)", + "output": "Purine Nucleotides described as nicotinamide Adenine Dinucleotide Phosphate, an oxidation-reduction coenzyme, found in eukaryotic cells and is involved in many enzymatic reactions." + }, + { + "input": "Concept: body frame size (Body measure procedure)", + "output": "something described as the categorization of a person's body frame into small, medium and large based on the measurement of wrist circumference or the breadth of the elbow." + }, + { + "input": "Concept: LOSATUXIZUMAB VEDOTIN (Amino Acid, Peptide, or Protein)", + "output": "Pharmacologic Substance described as an antibody-drug conjugate (ADC) composed of an immunoglobulin G1 (IgG1) monoclonal antibody directed against the epidermal growth factor receptor (EGFR), conjugated, via a protease-cleavable peptide linker, to monomethyl auristatin E (MMAE), an auristatin derivative and a potent microtubule inhibitor, with potential antineoplastic activity. Upon administration, the monoclonal antibody moiety of losatuxizumab vedotin selectively targets and binds to EGFR. Upon internalization and proteolytic cleavage, MMAE binds to tubulin and inhibits its polymerization, resulting in G2/M phase arrest and tumor cell apoptosis. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization." + }, + { + "input": "Concept: I Could Go to This Doctor for Care of Ongoing Problem (Intellectual Product)", + "output": "Clinical or Research Assessment Question described as a question about whether an individual could see a particular doctor for an ongoing problem." + }, + { + "input": "Concept: detection of injury (detection of external stimulus)", + "output": "Cell Function described as the series of events by which an injury stimulus is received and converted into a molecular signal." + }, + { + "input": "Concept: Galanin-3 Receptor (galanin receptor)", + "output": "galanin receptor described as a galanin receptor subtype with high affinity for GALANIN-LIKE PEPTIDE and low affinity for full length GALANIN and galanin peptide fragments." + }, + { + "input": "Concept: THROMBOPENIA (Platelet Count measurement)", + "output": "Purpura and other hemorrhagic conditions described as a reduction in the number of circulating thrombocytes." + }, + { + "input": "Concept: upstream transcription factor 1 (Transcription factor genes)", + "output": "something described as this gene plays a role in the transcriptional activation of genes involved in glucose and lipid homeostasis." + }, + { + "input": "Concept: Flutamidum (Anti-androgen hormone antagonists and related agents)", + "output": "Drug allergens described as an anticancer drug that is a type of antiandrogen." + }, + { + "input": "Concept: Hypertonic Stresses (Natural Phenomenon or Process)", + "output": "something described as a change in the osmotic pressure caused by an increase in the concentration of solution to which a cell is exposed." + }, + { + "input": "Concept: N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine (Antiparasitic Agents)", + "output": "Antimalarial [EPC] described as antiamebic and antimalarial; chloroquine phosphate is also listed by USP as a suppressant of lupus erythematosus." + }, + { + "input": "Concept: Impaired cytokine signaling (Finding)", + "output": "Abnormal cytokine signaling described as a defect or impairment in the series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. []" + }, + { + "input": "Concept: Image mode (Intellectual Product)", + "output": "something described as image mode refers to the type of image acquisition (modality). For example, most ultrasound systems use 2D, Color Flow, M Mode and Doppler modes." + }, + { + "input": "Concept: Psychological Generalization (Mental Process)", + "output": "something described as the process of formulating general concepts by abstracting common properties of instances; reasoning from detailed facts to general principles." + }, + { + "input": "Concept: regulation of TLR21 signaling pathway (regulation of toll-like receptor signaling pathway)", + "output": "Molecular Function described as any process that modulates the frequency, rate or extent of toll-like receptor 21 signaling pathway." + }, + { + "input": "Concept: naphthalene biosynthetic process (aromatic compound biosynthetic process)", + "output": "aromatic compound biosynthetic process described as the chemical reactions and pathways resulting in the formation of naphthalene." + }, + { + "input": "Concept: DHH protein, human (Signaling Protein)", + "output": "something described as desert hedgehog protein (396 aa, ~344 kDa) is encoded by the human DHH gene. This protein plays a role in the regulation of male gonadal morphogenesis." + }, + { + "input": "Concept: upregulation of DNA replication involved in S phase involved in mitotic cell cycle (positive regulation of mitotic cell cycle)", + "output": "Cell Function described as any process that activates or increases the frequency, rate or extent of mitotic cell cycle DNA replication." + }, + { + "input": "Concept: FLURAZEPAM (Benzodiazepine [EPC])", + "output": "Organic Chemical described as benzodiazepine derivative used mainly as a sedative and hypnotic in the treatment of insomnia." + }, + { + "input": "Concept: ilms (Body Part, Organ, or Organ Component)", + "output": "Body Part, Organ, or Organ Component described as one of three parts of the limiting sulcus in the human ( Ture-1999 ). Identified by dissection, it separates the insula from the superior temporal gyrus of the temporal lobe. The other parts are the superior limiting sulcus and the anterior limiting sulcus. In the macaque it is one of just two parts; the other is the superior limiting sulcus. The limiting sulcus is not present in rodents." + }, + { + "input": "Concept: Family Methanobacteriaceae (Bacteria)", + "output": "something described as a family of anaerobic, coccoid to rod-shaped METHANOBACTERIALES. Cell membranes are composed mainly of polyisoprenoid hydrocarbons ether-linked to glycerol. Its organisms are found in anaerobic habitats throughout nature." + }, + { + "input": "Concept: Left-Right Determination, Factor B Gene (LEFTY1 gene)", + "output": "LEFTY1 gene described as human LEFTY1 wild-type allele is located in the vicinity of 1q42.1 and is approximately 3 kb in length. This allele, which encodes left-right determination factor B protein, plays a role in left-right asymmetry determination of organ systems during development." + }, + { + "input": "Concept: Synapsins (Actin-Binding Protein)", + "output": "Phosphoproteins described as found in synaptic terminals and is associated with synaptic vesicles; when phosphorylated, it dissociates from the vesicle membrane, allowing the vesicle to fuse with plasma membrane so that neurotransmitter can be released." + }, + { + "input": "Concept: Stage II Ovarian Dysgerminoma AJCC v6 and v7 (Stage II Ovarian Germ Cell Tumor AJCC v6 and v7)", + "output": "Stage II Ovarian Germ Cell Tumor AJCC v6 and v7 described as stage II includes: T2, N0, M0. T2: Tumor involves one or both ovaries with pelvic extension and/or implants. N0: No regional lymph node metastasis. M0: No distant metastasis." + }, + { + "input": "Concept: Occult Carcinoma of Lung (Neoplastic Process)", + "output": "something described as a lung carcinoma detectable by sputum cytology or bronchial washings only. The primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed." + }, + { + "input": "Concept: VHR (Gene or Genome)", + "output": "Gene or Genome described as this gene plays a role in the inactivation of proteins involved in cellular differentiation and proliferation." + }, + { + "input": "Concept: low ldl (Cholesterol measurement test)", + "output": "Hypolipoproteinemias described as an decreased concentration of low-density lipoprotein cholesterol in the blood." + }, + { + "input": "Concept: Absorption, Vaginal (Organ or Tissue Function)", + "output": "something described as the uptake of substances from the VAGINA via the vaginal epithelium/mucosa." + }, + { + "input": "Concept: Sidebending (Clinical Drug)", + "output": "something described as movement in a coronal (frontal) plane about an anterior-posterior (x) axis." + }, + { + "input": "Concept: muscarine (Trimethyl Ammonium Compounds)", + "output": "FUNGAL POISONS AND PRODUCTS described as toxic cholinomimetic alkaloid occurring in Amanita muscaria and other mushrooms; causes profound parasympathetic activation that may end in convulsions and death; the specific antidote is atropine." + }, + { + "input": "Concept: CANAVAN-VAN BOGAERT-BERTRAND DISEASE (Lysosomal Storage Diseases)", + "output": "Disorder of amino acid and organic acid metabolism described as a disorder that belongs in the group of leukodystrophies. It is caused by mutations in the ASPA gene which is responsible for the production of the enzyme aspartoacylase. It is characterized by spongy degeneration of the white matter of the brain. Signs and symptoms appear in infancy and include mental retardation, loss of motor skills, abnormal muscle tone, feeding difficulties and a very large head." + }, + { + "input": "Concept: PAPS sulfatase activity (hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides)", + "output": "something described as catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + H2O = adenosine 3',5'-bisphosphate + sulfate." + }, + { + "input": "Concept: pyrimidine nucleotide transport (Cell Function)", + "output": "Cell Function described as the directed movement of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, into, out of or within a cell." + }, + { + "input": "Concept: GLUT4 (Gene or Genome)", + "output": "Gene or Genome described as this gene plays a role in glucose transport regulation." + }, + { + "input": "Concept: DEGARELIX (Hormone)", + "output": "Hormone Antagonists described as a long-acting, synthetic peptide with gonadotrophin-releasing hormone (GnRH) antagonistic properties. Degarelix targets and blocks GnRH receptors located on the surfaces of gonadotroph cells in the anterior pituitary, thereby reducing secretion of luteinizing hormone (LH) by pituitary gonadotroph cells and so decreasing testosterone production by interstitial (Leydig) cells in the testes." + }, + { + "input": "Concept: Sym-015 (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as a mixture of two humanized immunoglobulin G1 (IgG1) monoclonal antibodies, Hu9006 and Hu9338, which recognize non-overlapping epitopes in the extracellular domain of the human hepatocyte growth factor receptor (MET; HGFR; c-Met), with potential antineoplastic activity. Upon administration, anti-MET monoclonal antibody mixture Sym015 targets and binds to the extracellular domain of MET, thereby preventing the binding of its ligand, hepatocyte growth factor (HGF). This may prevent activation of the receptor and MET-mediated signal transduction pathways. This inhibits MET-dependent tumor cell proliferation. MET, a receptor tyrosine kinase, is overexpressed on the cell surfaces of various solid tumor cell types; it plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C127906\" active clinical trials using this agent." + }, + { + "input": "Concept: Appendiceal Carcinoma Pathologic Distant Metastasis TNM Finding v8 (Appendiceal Carcinoma Pathologic TNM Finding v8)", + "output": "Finding described as a pathologic finding about one or more characteristics of appendiceal carcinoma, following the rules of the TNM AJCC v8 classification system as they pertain to distant metastases." + }, + { + "input": "Concept: PLAT Gene (Peptidase Gene)", + "output": "Gene or Genome described as this gene is involved in blood coagulation, cell migration and tissue remodeling." + }, + { + "input": "Concept: social; deprivation (Social Processes)", + "output": "something described as limited access to society's resources due to poverty, neglect, social discrimination, or other disadvantage. For a lack of social contact use SOCIAL ISOLATION. Consider also CULTURAL DEPRIVATION." + }, + { + "input": "Concept: Interferon-Gamma-Inducible Protein 10 (Immunologic Factor)", + "output": "CXC Chemokines described as c-X-C motif chemokine 10 (98 aa, ~11 kDa) is encoded by the human CXCL10 gene. This protein is involved in chemotaxis of monocytes and T-lymphocytes." + }, + { + "input": "Concept: T=pseudo3 icosahedral viral capsid (Cell Component)", + "output": "something described as the protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with pseudo T=3 symmetry. The T=pseudo3 capsid is composed of 12 pentameric and 20 hexameric capsomeres." + }, + { + "input": "Concept: debio 0932 (HSP90 Inhibitor)", + "output": "Pharmacologic Substance described as an orally active and small molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor Debio 0932 specifically blocks Hsp90, thereby inhibiting its chaperone function and promoting the degradation of its client proteins, many of which are oncogenic signaling proteins involved in tumor cell proliferation and survival. This may lead to an inhibition of tumor cell proliferation. Hsp90, a chaperone protein upregulated in a variety of tumor cells, regulates the folding, stabilization and degradation of many oncogenic signaling proteins. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C92572\" active clinical trials using this agent." + }, + { + "input": "Concept: Oral drops, liquid (Biomedical or Dental Material)", + "output": "something described as liquid, usually multidose preparation consisting of a liquid active substance per se, intended for oral use. The preparation is administered in small volumes by means of a suitable measuring device such as a dropper, pipette or oral syringe capable of accurate dosing of the liquid. The measured dose may be diluted in water or another suitable liquid before swallowing." + }, + { + "input": "Concept: Abnormality of the intervertebral disk (Anatomical Abnormality)", + "output": "Anatomical Abnormality described as an abnormality of the intervertebral disk." + }, + { + "input": "Concept: Prenatal Programming (Physiologic Function)", + "output": "something described as permanent alteration of tissue structures and functions as a result of prenatal environment, either positive or negative." + }, + { + "input": "Concept: interleukin-15-mediated signalling pathway (Cell Function)", + "output": "Cell Function described as a series of molecular signals initiated by the binding of interleukin-15 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." + }, + { + "input": "Concept: Major Salivary Gland Carcinoma Clinical Regional Lymph Nodes TNM Finding v8 (Major Salivary Gland Cancer Clinical TNM Finding v8)", + "output": "Major Salivary Gland Cancer Clinical TNM Finding v8 described as a clinical finding about one or more characteristics of major salivary gland cancer, following the rules of the TNM AJCC v8 classification system as they pertain to staging of regional lymph nodes." + }, + { + "input": "Concept: Nursery schools (Manufactured Object)", + "output": "Manufactured Object described as schools for children usually under five years of age." + }, + { + "input": "Concept: Physiologic Monitor Modules, Electrocardiography (Physiologic Monitor Modules)", + "output": "Medical Device described as modules designed to be used as a component of a physiologic monitor, along with related devices, to acquire, measure, and process information for the purpose of continuously monitoring the electrical activity of the heart and the associated electrocardiogram (ECG). These modules contain electronic circuits or other technology designed to acquire and/or process the signal from one or more physiologic sensors (e.g., electrodes) and transmit it to the physiologic monitor, which contains the software designed to support the module's intended function(s). Electrocardiography modules must be inserted in a dedicated location (e.g., \"slot\") within a physiologic monitor (e.g., modular or modular/configured bedside or transport monitor) or related device (e.g., module rack) in order to support the desired function(s). Typical functions of an electrocardiography module, when used with a physiologic monitor, include continuous 3-, 5-, and/or 6-lead ECG monitoring; heart rate numeric and ECG waveform(s) display; arrhythmia detection; ST-segment analysis; and appropriate initiation of visual/audible alarms. Some modules provide additional functions, such as 12-lead ECG monitoring and diagnostic interpretation." + }, + { + "input": "Concept: slingshot protein phosphatase 2 (Protein Phosphatase Gene)", + "output": "something described as this gene plays a role in both actin filament dynamics and protein dephosphorylation." + }, + { + "input": "Concept: Oogenesis (Functions and Abnormal Functions Associated with the Reproductive State)", + "output": "Reproductive function described as the complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster." + }, + { + "input": "Concept: Charlie M syndrome (Orbital separation excessive)", + "output": "Disease or Syndrome described as a rare bone developmental disorder belonging to a group of oromandibular limb hypogenesis syndromes. The major anomalies occuring commonly in this group are hypoplasia of the mandible, syndactyly and ectrodactyly, small mouth, cleft palate, hypodontia and facial paralysis. Patients with Charlie M syndrome also present with hypertelorism, absent or conically crowned incisors and variable degrees of hypodactyly of the hands and feet. There have been no further descriptions in the literature since 1976." + }, + { + "input": "Concept: Tea Dosage Form Category (Basic Dosage Form Category)", + "output": "something described as a type of solid pharmaceutical dose form consisting of one or more herbal drugs intended for preparation of a solution by decoction or maceration, or a lyophilised preparation of such a solution." + }, + { + "input": "Concept: sulfur oxygenase reductase activity (oxidoreductase activity)", + "output": "oxidoreductase activity described as catalysis of the reaction: 5 sulfur + oxygen + 4 H2O = sulfite + thiosulfate + 2 hydrogen sulfide + 9 H+." + }, + { + "input": "Concept: Allopathic & Osteopathic Physicians; Pathology, Forensic Pathology (Professional or Occupational Group)", + "output": "something described as a forensic pathologist is expert in investigating and evaluating cases of sudden, unexpected, suspicious and violent death as well as other specific classes of death defined by law. The forensic pathologist serves the public as coroner or medical examiner, or by performing medicolegal autopsies for such officials." + }, + { + "input": "Concept: positive regulation of acrosome reaction (Cell Function)", + "output": "positive regulation of fertilization described as any process that activates or increases the frequency, rate or extent of the acrosome reaction." + }, + { + "input": "Concept: Device Subject Relationships Supplemental Qualifiers Dataset (Supplemental Qualifiers Tabulation Dataset)", + "output": "Intellectual Product described as a dataset containing supplemental information, specifically non-standard variables, to parent records in the device subject relationships domain." + }, + { + "input": "Concept: New Tumor Confirmed (Conceptual Entity)", + "output": "Conceptual Entity described as the verification/confirmation by other methods or modalities that a tumor, which has not been previously seen or characterized, is present in the subject." + }, + { + "input": "Concept: quinazolines (Drug allergen by structure)", + "output": "Drug allergen by structure described as two ring heterocyclic compound." + }, + { + "input": "Concept: atrioventricular bundle (Heart part)", + "output": "Structure of atrioventricular node described as small band of specialized CARDIAC MUSCLE fibers that originates in the ATRIOVENTRICULAR NODE and extends into the membranous part of the interventricular septum. The bundle of His, consisting of the left and the right bundle branches, conducts the electrical impulses to the HEART VENTRICLES in generation of MYOCARDIAL CONTRACTION." + }, + { + "input": "Concept: French-American-British Classification (Intellectual Product)", + "output": "something described as a classification system for acute myeloid leukemias, acute lymphoblastic leukemias, and myelodysplastic syndromes. It is based on the morphologic and cytochemical evaluation of bone marrow and peripheral blood smears." + }, + { + "input": "Concept: Aquaporin 6 (Amino Acid, Peptide, or Protein)", + "output": "something described as aquaporin 6 is an aquaglyceroporin that is found primarily in KIDNEY COLLECTING DUCTS. AQP6 protein functions as an anion-selective channel." + }, + { + "input": "Concept: QIDS-SR - Decreased Weight (QIDS-SR Questionnaire Question)", + "output": "Intellectual Product described as quick Inventory of Depressive Symptomatology Self-Report Version (QIDS-SR) Please circle the one response to each item that best describes you for the past seven days: within the last two weeks: Decreased weight." + }, + { + "input": "Concept: Alprazolam-containing product (Anti-Anxiety Agents)", + "output": "Benzodiazepine [EPC] described as a drug used to treat anxiety disorders and panic attacks" + }, + { + "input": "Concept: Heat, NOS (Energy, Physics)", + "output": "Temperature extreme described as the form of energy and the sensation of an increase in temperature. Its interest in medicine is largely with reference to its physiological effects, its therapeutic use, and its use in procedures in physics and physical chemistry." + }, + { + "input": "Concept: Insulin Receptor Substrate 2 (Adaptor Proteins, Signal Transducing)", + "output": "something described as insulin receptor substrate 2 (1338 aa, ~137 kDa) is encoded by the human IRS2 gene. This protein is involved in insulin-dependent signal transduction." + }, + { + "input": "Concept: Colon or Rectum Neuroendocrine Tumor pT3 TNM Finding v7 (Finding)", + "output": "Finding described as colon or rectum neuroendocrine tumor invading through the muscularis propria into the subserosa, or into non-peritonealized pericolic or perirectal tissues." + }, + { + "input": "Concept: 4-Quinazolinamine, N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]- (Antineoplastic Enzyme Inhibitor)", + "output": "Antineoplastic Enzyme Inhibitor described as a substance being studied in the treatment of some types of cancer. AZD0530 blocks enzymes needed for cancer growth. It is a type of tyrosine kinase inhibitor." + }, + { + "input": "Concept: Grade 1 Neonatal Administration Site Complication, Adverse Event (Neonatal Administration Site Complication, AE)", + "output": "Finding described as an administration site complication adverse event in a newborn characterized by painless edema." + }, + { + "input": "Concept: JAK-Binding Protein (Amino Acid, Peptide, or Protein)", + "output": "something described as suppressor of cytokine signaling 1 (211 aa, ~24 kDa) is encoded by the human SOCS1 gene. This protein is involved in the modulation of cytokine signaling." + }, + { + "input": "Concept: Bexarotene (Organic Chemical)", + "output": "benzoic acid described as a synthetic retinoic acid agent with potential antineoplastic, chemopreventive, teratogenic and embryotoxic properties. Bexarotene selectively binds to and activates retinoid X receptors (RXRs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, apoptosis of some cancer cell types, and tumor regression. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1635\" active clinical trials using this agent." + }, + { + "input": "Concept: regulation of L-proline oxidase activity (Molecular Function)", + "output": "something described as any process that modulates the frequency, rate or extent of pyrroline-5-carboxylate reductase activity." + }, + { + "input": "Concept: skin testing (immunology studies)", + "output": "Immunology procedure described as a test for an immune response to a compound by placing it on or under the skin." + }, + { + "input": "Concept: Supraglottic Cancer Pathologic TNM Finding v7 (Finding)", + "output": "Finding described as a pathologic finding about one or more characteristics of supraglottic cancer, following the rules of the TNM AJCC v7 classification system. The pathologic staging requires the use of all information obtained in clinical staging and in histologic study of the surgically resected specimens." + }, + { + "input": "Concept: Self-Management: Acute Illness (Health management)", + "output": "Finding described as personal actions to manage a reversible illness, its treatment, and to prevent complications" + }, + { + "input": "Concept: HYPOTHALAMUS (Limbic System)", + "output": "something described as a small region of the brain composed of multiple nuclei and located underneath the thalamus." + }, + { + "input": "Concept: IBA (Malayo-Polynesian language)", + "output": "something described as an Austronesian language spoken by the Iban people of the Malaysian state of Sarawak, the Indonesian province of West Kalimantan, and in Brunei." + }, + { + "input": "Concept: Delayed CNS myelination (Anatomical Abnormality)", + "output": "Anatomical Abnormality described as delayed myelination in the central nervous system." + }, + { + "input": "Concept: Phytomenadione (Vitamin measurement)", + "output": "Vitamin measurement described as the determination of the amount of the Vitamin K1 in a sample." + }, + { + "input": "Concept: System, Multi Institutional (Organization and Administration)", + "output": "Organization and Administration described as institutional systems consisting of more than one health facility which have cooperative administrative arrangements through merger, affiliation, shared services, or other collective ventures." + }, + { + "input": "Concept: Pleural Malignant Mesothelioma cM1 TNM Finding v8 (Pleural Malignant Mesothelioma Clinical Distant Metastasis TNM Finding v8)", + "output": "something described as pleural malignant mesothelioma with distant metastasis." + }, + { + "input": "Concept: Respirable Crystalline Silica (Hazardous or Poisonous Substance)", + "output": "silicon dioxide described as a widespread, naturally occurring, crystalline metal oxide that consists of different forms including quartz, cristobalite, tridymite, tripoli, ganister, chert and novaculite. Respirable crystalline silica is found in industry in metal and nonmetal mining and milling operations as well as in foundries, ceramic industries and at construction sites. Inhalation exposure to respirable crystalline silica causes chronic silicosis, emphysema, lymph node fibrosis and is associated with an increased risk of developing lung cancer." + }, + { + "input": "Concept: BPI1TC (CDISC Questionnaire Terminology)", + "output": "something described as test codes of questionnaire questions associated with the brief pain inventory (BPI) for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: VISITDY (Temporal Concept)", + "output": "something described as the day of the week of a visit." + }, + { + "input": "Concept: pancreas development (Organogenesis)", + "output": "Organogenesis described as the process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes." + }, + { + "input": "Concept: regulation of inner ear receptor cell differentiation (regulation of mechanoreceptor differentiation)", + "output": "regulation of mechanoreceptor differentiation described as any process that modulates the frequency, rate or extent of inner ear receptor cell differentiation." + }, + { + "input": "Concept: deoxyribonucleic acid repair (DNA metabolic process)", + "output": "nucleic acid metabolism described as reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions; the major repair mechanisms are excision repair, photoreactivation repair, and post-replication repair." + }, + { + "input": "Concept: seizure disorder status epilepticus (Korean Standard Classification of Disease Version 5)", + "output": "Central Nervous System described as a prolonged seizure, or two or more discrete seizures without complete recovery of consciousness between seizures." + }, + { + "input": "Concept: spleen disorder (Non-Immunologic Hematopoietic Diseases and Syndromes)", + "output": "Blood and lymphatic system disorders described as condition in which there is a deviation from or interruption of the normal structure or function of the spleen." + }, + { + "input": "Concept: MIR377 Gene (Gene or Genome)", + "output": "Gene or Genome described as this gene is involved in the regulation of gene expression and plays a role in the development of epithelial ovarian carcinoma and diabetic nephropathy." + }, + { + "input": "Concept: Tsunami (Disasters)", + "output": "Natural Phenomenon or Process described as series of ocean waves produced by geologic events or underwater LANDSLIDES. These waves can travel at speeds averaging 450 (and up to 600) miles per hour in the open ocean." + }, + { + "input": "Concept: Specify Other BRAF Codon 600 Mutation (Intellectual Product)", + "output": "Intellectual Product described as a request to enter the specific mutation involving BRAF codon 600 that was identified in the study but is not present in the form." + }, + { + "input": "Concept: CRQ02-Energy (CRQ-SAS Follow-Up Administration Version Questionnaire Question)", + "output": "something described as chronic Respiratory Questionnaire Self-Administered Standardized Format Follow-Up Administration Version Questionnaire (CRQ-SAS Follow-Up Administration Version) How much energy have you had in the last 2 weeks?" + }, + { + "input": "Concept: Stippling of the epiphyses of the 3rd finger (Epiphyseal stippling of finger phalanges)", + "output": "Anatomical Abnormality described as the presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the 3rd finger." + }, + { + "input": "Concept: GTF3C2 (Biologically Active Substance)", + "output": "Amino Acid, Peptide, or Protein described as general transcription factor 3C polypeptide 2 (911 aa, ~101 kDa) is encoded by the human GTF3C2 gene. This protein plays a role in the mediation of RNA polymerase III-mediated transcription." + }, + { + "input": "Concept: Childhood Follicular Lymphoma (Neoplastic Process)", + "output": "Lymphoma, Follicular described as a nodal follicular lymphoma with favorable prognosis. It lacks BCL-2 rearrangement and 14;18 translocation. Nearly all cases are localized. It is usually seen in the pediatric population but similar lymphomas may occur in adults." + }, + { + "input": "Concept: pT1b Cancer of the Uterus TNM Finding v6 (Finding)", + "output": "Uterine Corpus Cancer Pathologic Primary Tumor TNM Finding v6 described as uterine corpus cancer with tumor invasion of less than one-half of the myometrium." + }, + { + "input": "Concept: glutamate dehydrogenase [NAD(P)+] activity (oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor)", + "output": "oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor described as catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+." + }, + { + "input": "Concept: Yersinia enterocolitica biogroup 3B (Yersinia )", + "output": "Bacterium described as any bacterial organism that can be assigned to the species Yersinia bercovieri." + }, + { + "input": "Concept: undifferentiated carcinoma of larynx (Neoplastic Process)", + "output": "Undifferentiated carcinoma described as an undifferentiated carcinoma that arises from the larynx. This category includes lymphoepithelial carcinoma and giant cell carcinoma." + }, + { + "input": "Concept: Optical Imaging (Diagnostic Imaging)", + "output": "something described as the use of light interaction (scattering, absorption, and fluorescence) with biological tissue to obtain morphologically based information. It includes measuring inherent tissue optical properties such as scattering, absorption, and autofluorescence; or optical properties of exogenous targeted fluorescent molecular probes such as those used in optical MOLECULAR IMAGING, or nontargeted optical CONTRAST AGENTS." + }, + { + "input": "Concept: FOXP4 Gene (Gene or Genome)", + "output": "something described as this gene plays a role in the tissue-specific repression of gene transcription." + }, + { + "input": "Concept: up-regulation of oxidized nicotinamide adenine dinucleotide metabolic process (regulation of NAD metabolic process)", + "output": "something described as any process that activates or increases the frequency, rate or extent of NAD metabolic process." + }, + { + "input": "Concept: Bcl-2 Homologous Antagonist/Killer (Proto-Oncogene Proteins c-bcl-2)", + "output": "Proto-Oncogene Proteins c-bcl-2 described as bcl-2 homologous antagonist/killer (211 aa, ~23 kDa) is encoded by the human BAK1 gene. This protein is involved in both protein-protein interactions and apoptosis." + }, + { + "input": "Concept: Focal facial dermal dysplasia type I (Autosomal dominant hereditary disorder)", + "output": "Autosomal dominant hereditary disorder described as focal facial dermal dysplasia type I (FFDD1), also known as Brauer syndrome, is a focal facial dysplasia with characteristics of congenital bitemporal cutis aplasia. The bitemporal rarely unilateral hypoplastic scar-like lesions in FFDD, resembling forceps marks, are usually the only manifestations of FFDD1. Most patients usually have normal intelligence. Transmitted in an autosomal dominant manner with full penetrance." + }, + { + "input": "Concept: NITRITE (Laboratory Procedure)", + "output": "something described as a measurement of the nitrite in a biological specimen." + }, + { + "input": "Concept: Extrarenal Rhabdoid Tumor (Neoplastic Process)", + "output": "Neoplastic Process described as a rhabdoid tumor which arises in the soft tissues. It occurs in infants and children and may be associated with loss of chromosome 22. It is characterized by the presence of cells with a large eccentric nucleus, prominent nucleolus, and abundant cytoplasm." + }, + { + "input": "Concept: Bandages, Retention, Elastic (Bandages, Retention)", + "output": "Medical Device described as bandages designed with elastic properties. These bandages are usually made of mechanically crimped cotton and include some elastomer; they usually readily conform to body contour. The bandages usually extend in multiple directions (two-way stretch), imparting elasticity but little compression capability to the bandage. Elastic retention bandages may be covered with an adherent substance, and they are intended to retain dressings or other small devices (e.g., splints, intravenous catheters) in an appropriate position. They are not intended to support or compress a body part." + }, + { + "input": "Concept: cellular response to cholinergic differentiation factor (cellular response to cytokine stimulus)", + "output": "Cell Function described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus." + }, + { + "input": "Concept: fracture of wrist (Wrist Injuries)", + "output": "Fracture of distal end of radius and ulna described as a traumatic break in one of the small bones in the wrist." + }, + { + "input": "Concept: Delayed exfoliation of primary teeth (Abnormality of primary teeth)", + "output": "Oral lesion described as persistence of the primary teeth beyond the age by which they normally are shed and replaced by the permanent teeth." + }, + { + "input": "Concept: 8q24.12 (Cell Component)", + "output": "Chromosome band described as a chromosome band present on 8q" + }, + { + "input": "Concept: 6A3-5 (Transcription Regulation Gene)", + "output": "something described as this gene plays a role in both chromatin remodeling and transcriptional regulation." + }, + { + "input": "Concept: Corpus unguis (Region of nail)", + "output": "Nail plate described as part of the horny plate, which is attached to the nail bed, and is the intervening portion between the cuticle and the free edge of the nail." + }, + { + "input": "Concept: ADL01-Clear Dishes Usual Performance (Intellectual Product)", + "output": "Intellectual Product described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory - If yes, which best describes how he/she usually performed." + }, + { + "input": "Concept: CDISC-CLINDE (Intellectual Product)", + "output": "Clinical Data Interchange Standards Consortium Terminology described as the terminology relevant to the CDISC Clinical Data Element Glossary." + }, + { + "input": "Concept: ailanthi/bai chun pi (Oriental herbs and natural substances letter A)", + "output": "Oriental herbs and natural substances letter A described as bai chun pi" + }, + { + "input": "Concept: Spiny Anteaters (FAMILIES TACHYGLOSSIDAE AND ORNITHORHYNCHIDAE)", + "output": "Families tachyglossidae AND/OR ornithorhynchidae described as an oviparous burrowing mammal of the order Monotremata native to Australia, Tasmania, and New Guinea. It has hair mingled with spines on the upper part of the body and is adapted for feeding on ants." + }, + { + "input": "Concept: Dissatisfied With Some Things About the Medical Care I Receive (Intellectual Product)", + "output": "Clinical or Research Assessment Question described as a question about whether an individual is dissatisfied with some things about the medical care they receive." + }, + { + "input": "Concept: FATACFRS (Laboratory Procedure)", + "output": "Laboratory Procedure described as a measurement of the saturated non-esterified fatty acids in a biological specimen." + }, + { + "input": "Concept: Software, Device Testing (Computer software)", + "output": "Computer software described as software designed to operate device testers, control/monitor a limited number of the tester functions, and/or process data obtained while testing. This software may be intended to work with one or a few models of device testers, usually from the same manufacturer. The software may perform a variety of algorithms to facilitate the operation and analysis of the measurements performed while assessing the device parameters, and/or while processing and or receiving information from hospital information systems. Device testing software is not usually available separate from the tester but may be updated (i.e., through the release of modified versions) during the life of the tester; the software is mainly used in biomedical engineering departments located in healthcare facilities. Dedicated device testing software is available for a great variety of functions and/or devices, including electrical safety, cardiac pacemakers, infusion pumps, and ventilators." + }, + { + "input": "Concept: Grade 3 Neonatal Respiratory Distress Syndrome (Neonatal Respiratory Distress Syndrome, Adverse Event)", + "output": "Finding described as an adverse event in a newborn characterized by clinical evidence of increased respiratory distress with relevant deterioration in gas exchange (increase in partial pressure of carbon dioxide (pCO2) or decrease in oxygenation); requiring major care change (e.g. starting invasive support)." + }, + { + "input": "Concept: Identified Genomic Data and Samples (Genomic Data and Sample Coding Category)", + "output": "Genomic Data and Sample Coding Category described as identified data and samples are labelled with personal identifiers such as name or identification numbers (e.g., social security or national insurance number). As the samples and associated data are directly traceable back to the subject, it is possible to undertake actions such as sample withdrawal or the return of individual results. The use of identified data and samples allows for clinical monitoring, subject follow-up and the addition of new data. Identified data and samples coding offers privacy protection similar to general healthcare confidentiality in everyday medical practice. Identified data and sample coding are generally not considered appropriate for purposes of clinical trials in drug development." + }, + { + "input": "Concept: antigen receptor-mediated signaling pathway (immune response-activating cell surface receptor signaling pathway)", + "output": "immune response-activating cell surface receptor signaling pathway described as a series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell." + }, + { + "input": "Concept: Increased biotinidase level (Finding)", + "output": "something described as an increase in biotinidase level, an enzyme that releases biotin from biocytin, the product of biotin-dependent carboxylases degradation." + }, + { + "input": "Concept: ERBB1 c.2239 2247del9 (EGFR Exon 19 Deletion Mutation)", + "output": "Cell or Molecular Dysfunction described as a deletion of nine nucleotides from the coding sequence of the EGFR gene from position 2239 through 2247." + }, + { + "input": "Concept: blood vessel endothelial cell delamination (delamination process)", + "output": "something described as the process of negative regulation of cell adhesion that results in blood vessel endothelial cells splitting off from an existing endothelial sheet." + }, + { + "input": "Concept: Clonal (Qualitative Concept)", + "output": "something described as related by descent from a single progenitor cell." + }, + { + "input": "Concept: Ossification anomaly with psychomotor developmental delay syndrome (Dysplasia with defective mineralization)", + "output": "Congenital anomaly of thorax described as this syndrome has characteristics of hypomineralization of the cranial bones, thoracic dystrophy, hypotonia and abnormal and slender long bones due to an alteration in remodelling during ossification. It has been described in two brothers and was present at birth. The surviving boy displayed progressive osteopenia, slow healing of the periostal anomalies, hepatic angiomas, a thoracic deformity, delayed tooth eruption, progressive microcephaly with dilation of the cerebral ventricles and mental and motor delay." + }, + { + "input": "Concept: Ant pituitary hyperfunction (Hypothalamus and pituitary gland disorders)", + "output": "Pituitary Diseases described as diminution or cessatin of anterior pituitary function; leads to a variety of hormone deficiencies." + }, + { + "input": "Concept: Myocardium of muscular part of interventricular septum (Body Location or Region)", + "output": "Body Location or Region described as myocardium of region of heart which is continuous with the myocardium of right and left ventricles." + }, + { + "input": "Concept: recreations (Leisure)", + "output": "Leisure Activities described as any activity that is intended for refreshment or diversion." + }, + { + "input": "Concept: Pyruvate Dehydrogenase Complex Deficiency Disease (Disorder of pyruvate metabolism and mitochondrial respiratory chain)", + "output": "Inborn Errors of Metabolism described as an inherited metabolic disorder caused by deficient enzyme activity in the PYRUVATE DEHYDROGENASE COMPLEX, resulting in deficiency of acetyl CoA and reduced synthesis of acetylcholine. Two clinical forms are recognized: neonatal and juvenile. The neonatal form is a relatively common cause of lactic acidosis in the first weeks of life and may also feature an erythematous rash. The juvenile form presents with lactic acidosis, alopecia, intermittent ATAXIA; SEIZURES; and an erythematous rash. (From J Inherit Metab Dis 1996;19(4):452-62) Autosomal recessive and X-linked forms are caused by mutations in the genes for the three different enzyme components of this multisubunit pyruvate dehydrogenase complex. One of the mutations at Xp22.2-p22.1 in the gene for the E1 alpha component of the complex leads to LEIGH DISEASE." + }, + { + "input": "Concept: Perinatal-Stress Induced Hyperinsulinism (Disorder of endocrine pancreas)", + "output": "something described as transient hyperinsulinism that occurs in response to neonatal stress, resulting in prolonged neonatal hypoglycemia, which is distinct from transitional hypoglycemia of typical infants." + }, + { + "input": "Concept: Diaphragma Sellae (Supratentorial brain part)", + "output": "Supratentorial brain part described as a fold of dura mater covering the sella turcica, which forms the roof over the pituitary fossa. It has a small opening in its center, through which the pituitary stalk passes." + }, + { + "input": "Concept: Processor (Organization)", + "output": "Manufacturer Name described as a person, enterprise, or entity that prepares products for marketing or distribution." + }, + { + "input": "Concept: Cisplatin/Fluorouracil/Gemcitabine Regimen (Regimen Used to Treat Pancreatic Carcinoma)", + "output": "something described as a chemotherapy regimen consisting of gemcitabine, 5-fluorouracil and cisplatin that can be used in the treatment of hepatobiliary and pancreatic cancers." + }, + { + "input": "Concept: MGC16733 (Gene or Genome)", + "output": "something described as this gene is involved in the transcription of small nuclear RNAs." + }, + { + "input": "Concept: cilium basal body of left caudal flagellum (Cell Component)", + "output": "something described as any ciliary basal body that is part of a left caudal flagellum found in Giardia species (trophozoite stage)." + }, + { + "input": "Concept: Congenital Amegakaryocytosis (Amegakaryocytosis)", + "output": "Amegakaryocytosis described as a rare disorder of infancy characterized by a marked reduction in, or a complete absence of, megakaryocytes, and thrombocytopenia." + }, + { + "input": "Concept: 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, ethyl ester (Histamine H1 Antagonists)", + "output": "something described as a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness." + }, + { + "input": "Concept: IVD Panels, Human Genetics, Neurodegenerative Disorder, Dementia, Frontotemporal (IVD Panels, Human Genetics, Neurodegenerative Disorder, Dementia)", + "output": "Medical Device described as molecular assay reagents intended to identify gene variants associated with frontotemporal dementias, a collection of neurodegenerative disorders characterized by atrophy of the frontal and temporal brain lobes. Genetic variants at multiple loci have been associated with frontotemporal dementias. These reagents are intended to detect various types of genetic changes (e.g., deletions, duplications, insertions, single nucleotide polymorphisms) in multiple frontotemporal dementia-associated loci simultaneously." + }, + { + "input": "Concept: Very Tired (Finding)", + "output": "something described as a response indicating that an individual is or was very tired." + }, + { + "input": "Concept: Temozolodida (Organic Chemical)", + "output": "Triazenes described as dacarbazine derivative; alkylating antineoplastic agent." + }, + { + "input": "Concept: DCLK1 Gene (Gene or Genome)", + "output": "Serine/Threonine Protein Kinase Gene described as this gene is involved in microtubule polymerization, retrograde transport and neuronal development and migration." + }, + { + "input": "Concept: BRCA1 Gene (Homologous Recombination Repair Gene)", + "output": "Gene Mutation described as this gene plays a role in cell cycle control, regulation of transcription and the maintenance of genomic stability. It is also involved in the inhibition of mammary cell growth." + }, + { + "input": "Concept: Suspending Excipient (Biomedical or Dental Material)", + "output": "Pharmaceutical Excipient described as therapeutically inactive ingredient of pharmaceutical dosage form used to prevent aggregation of the active drug in liquid form, allowing uniform concentrations to be maintained for accurate dosing." + }, + { + "input": "Concept: SCLERODERMA (Skin, Human)", + "output": "SKIN, NAILS, HAIR described as pathologic thickening or hardening of skin" + }, + { + "input": "Concept: Cirrhosis of the Liver Secondary to Hepatitis B (Disease or Syndrome)", + "output": "something described as cirrhosis of the liver that develops as a sequelae of a hepatitis b infection." + }, + { + "input": "Concept: PedsQL Neuromuscular Module Acute Version 3.0 Child Report - Hands Are Weak (Intellectual Product)", + "output": "something described as pediatric Quality of Life Neuromuscular Module Acute Version 3.0 Child Report (PedsQL Neuromuscular Module Acute Version 3.0 Child Report) In the past 7 days, how much of a problem has this been for you: My hands are weak." + }, + { + "input": "Concept: phosphatidylcholine:cardiolipin linoleoyltransferase (Molecular Function)", + "output": "Molecular Function described as catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group from phosphatidylcholine to an oxygen atom on a cardiolipin molecule." + }, + { + "input": "Concept: Stage IVB Appendix Cancer (Neoplastic Process)", + "output": "Neoplastic Process described as stage IVB includes: (Any T, N0, M1a, G2, G3); (Any T, N1, M1a, Any G); (Any T, N2, M1a, Any G). N0: No regional lymph node metastasis. N1: Metastasis in 1-3 regional lymph nodes. N2: Metastasis in four or more regional lymph nodes. M1a: Intraperitoneal metastasis beyond the right lower quadrant, including pseudomyxoma peritonei. G2: Moderately differentiated tumor. G3: Poorly differentiated tumor." + }, + { + "input": "Concept: Action, Capillary (Surface Properties)", + "output": "something described as a phenomenon in which the surface of a liquid where it contacts a solid is elevated or depressed, because of the relative attraction of the molecules of the liquid for each other and for those of the solid." + }, + { + "input": "Concept: Grade 1 Hypocalcemia, CTCAE (Hypocalcemia, CTCAE)", + "output": "Hypocalcemia, CTCAE described as corrected serum calcium of T (Cell or Molecular Dysfunction)", + "output": "something described as a nucleotide substitution at position 2374 of the coding sequence of the EGFR gene where cytosine has been mutated to thymine." + }, + { + "input": "Concept: Partial Receptor Agonist (Agonist)", + "output": "Agonist described as a class of substances that binds to and activates a receptor with less efficacy, and produces submaximal receptor activation relative to a full agonist." + }, + { + "input": "Concept: Family iridaceae (Angiosperm)", + "output": "Phylogenetic group 15 described as a plant family of the Asparagales order. Comprised of perennial herbs with BULBS, corms, or RHIZOMES and grass-like leaves with bisexual flowers that have 2 whorls of petaloid tepals which are usually showy." + }, + { + "input": "Concept: scheies syndrome (Lysosomal Storage Diseases)", + "output": "Mucopolysaccharidosis I described as an autosomal recessive disorder representing the milder form of mucopolysaccharidosis type I. It is characterized by deficiency of the enzyme alpha-L-iduronidase. Signs and symptoms include broad mouth with full lips, cloudy cornea which may lead to blindness, stiff joints, and hirsutism." + }, + { + "input": "Concept: Fusion Toxin (Toxin)", + "output": "something described as a receptor-targeted complex comprised of a truncated toxin fused to a hormone, growth factor, or immunologic agent (i.e. antibody) that binds to the tumor cell allowing the toxin to kill the cell following internalization." + }, + { + "input": "Concept: PAROXYSMAL AV BLOCK (Conduction disorder of the heart)", + "output": "Conduction disorder of the heart described as an electrocardiographic finding of the sudden onset of transient AV block, which is often associated with preexisting conduction disorders." + }, + { + "input": "Concept: multicarotenoid supplement MCS-8 (Dietary Supplements)", + "output": "Dietary Supplements described as a supplement containing multiple, as of yet undisclosed, carotenoids, with potential chemopreventive activity. Upon oral administration of the multicarotenoid supplement MCS-8, the carotenoids may be able to exert their chemopreventive activity through multiple mechanisms of action." + }, + { + "input": "Concept: Teething ring, fluid-filled (General hospital device)", + "output": "General hospital device described as a teething ring is a divice intended for use by infants for medical purposes to soothe gums during the teething process." + }, + { + "input": "Concept: SGS - Short gut syndrome (Gastrointestinal and hepatobiliary procedural complications)", + "output": "gastrointestinal described as a malabsorption syndrome resulting from extensive operative resection of the SMALL INTESTINE, the absorptive region of the GASTROINTESTINAL TRACT." + }, + { + "input": "Concept: Otorhinolaryngologic Surgical Procedures (Operative Surgical Procedures)", + "output": "Therapeutic or Preventive Procedure described as surgery performed on the ear and its parts, the nose and nasal cavity, or the throat, including surgery of the adenoids, tonsils, pharynx, and trachea." + }, + { + "input": "Concept: Major Salivary Gland Cancer Pathologic TNM Finding v7 (Finding)", + "output": "Major Salivary Gland Cancer TNM Finding v7 described as a pathologic finding about one or more characteristics of major salivary gland cancer, following the rules of the TNM AJCC v7 classification system." + }, + { + "input": "Concept: Leu-9 Positive Neoplastic Cells Present (Finding)", + "output": "Finding described as an indication that expression of CD7 has been detected in a sample of neoplastic cells." + }, + { + "input": "Concept: 1,3-Dimethyl-6-(3-Ethylureido)-Uridine (Nucleic Acid, Nucleoside, or Nucleotide)", + "output": "Nucleic Acid, Nucleoside, or Nucleotide described as a ureido-derivative of pyrimidine developed to induce leukemic cell differentiation. This agent has been shown to induce erythroleukemia cell differentiation." + }, + { + "input": "Concept: Refractory Aggressive NK-Cell Leukemia (Refractory Lymphoproliferative Disorder)", + "output": "Aggressive natural killer-cell leukemia described as aggressive NK-cell leukemia that is resistant to treatment." + }, + { + "input": "Concept: down regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport (Molecular Function)", + "output": "something described as any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." + }, + { + "input": "Concept: Specimen Retention Indicator (Indicator)", + "output": "Indicator described as an indication as to whether the biological specimen is retained for a period of time." + }, + { + "input": "Concept: Millimole per Second (Unit of Dose Calculation)", + "output": "something described as a unit of substance flow rate equal to one millimole per second." + }, + { + "input": "Concept: Erysipelothrix rhusiopathiae Ag (Erysipelothrix rhusiopathiae)", + "output": "Immunologic Factor described as erysipelothrix rhusiopathiae serological reagents are devices that consist of antigens and antisera used in serological tests to identify Erysipelothrix rhusiopathiae from cultured isolates derived from clinical specimens. The identification aids in the diagnosis of disease caused by this bacterium belonging to the genus Erysipelothrix. This organism is responsible for a variety of inflammations of the skin following skin abrasions from contact with fish, shellfish, or poultry." + }, + { + "input": "Concept: Childhood Choroid Plexus Carcinoma (Childhood Choroid Plexus Neoplasm)", + "output": "Choroid Plexus Carcinoma described as a choroid plexus carcinoma that occurs during childhood." + }, + { + "input": "Concept: 1-alkylglycerophosphocholine O-acyltransferase activity (O-acyltransferase activity)", + "output": "Molecular Function described as catalysis of the reaction: 1-alkyl-sn-glycero-3-phosphocholine + acyl-CoA = 1-alkyl-2-acyl-sn-glycero-3-phosphocholine + CoA." + }, + { + "input": "Concept: erythronate-4-phosphate dehydrogenase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the reaction: 4-phospho-D-erythronate + NAD(+) = (R)-3-hydroxy-2-oxo-4-phosphonooxybutanoate + H(+) + NADH." + }, + { + "input": "Concept: N-terminal protein myristoylation (N-terminal protein lipidation)", + "output": "N-terminal protein lipidation described as the covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein." + }, + { + "input": "Concept: Abnormal urine protein level (Finding)", + "output": "Finding described as any deviation of the concentration of one or more proteins in the urine. []" + }, + { + "input": "Concept: Dysfunctional Labor Level of Diagnostic Certainty (Intellectual Product)", + "output": "GAIA Obstetric Case Definitions described as a classification of maternal and fetal outcomes relating to dysfunctional labor, developed by the Global Alignment of Immunization safety Assessment in pregnancy, based on the extent to which the diagnosis has been confirmed." + }, + { + "input": "Concept: Plexus uretericus (Autonomic nervous system)", + "output": "Body Part, Organ, or Organ Component described as an autonomic plexus that is derived from the celiac plexus, more specifically renal and hypogastric plexi, that accompanies the ureteric artery to the ureter." + }, + { + "input": "Concept: Cytomegalovirus IE-1-specific Cytotoxic T Lymphocytes (Biologically Active Substance)", + "output": "Pharmacologic Substance described as cytotoxic T-lymphocytes (CTLs), specifically reactive to the cytomegalovirus (CMV) immediate early-1 (IE-1) protein, with immunomodulating activity. Adoptive immunotherapy with cytomegalovirus IE-1-specific cytotoxic T lymphocytes may help reconstitute CD8+ cytomegalovirus-specific CTL responses in CMV-infected immunocompromised hosts. IE-1 is one of the first CMV antigens expressed by CMV-infected cells, predominantly inducing a CD8+ CTL response." + }, + { + "input": "Concept: C16orf77 (Interleukin Gene)", + "output": "something described as this gene plays a role in receptor binding and cytokine-dependent signaling." + }, + { + "input": "Concept: Dental impression materials (Biomedical or Dental Material)", + "output": "Dental Materials described as substances used to create an impression, or negative reproduction, of the teeth and dental arches; these materials include dental plasters and cements, metallic oxide pastes, silicone base materials, or elastomeric materials." + }, + { + "input": "Concept: SUMMER (Seasons)", + "output": "Seasons described as the season between the summer solstice and the autumnal equinox." + }, + { + "input": "Concept: gibberellin transmembrane transporter activity (carboxylic acid transmembrane transporter activity)", + "output": "carboxylic acid transmembrane transporter activity described as enables the transfer of gibberellin from one side of a membrane to the other." + }, + { + "input": "Concept: N-terminal peptidyl-isoleucine methylation (peptidyl-isoleucine modification)", + "output": "Molecular Function described as the methylation of the N-terminal isoleucine of proteins to form the derivative N-methyl-L-isoleucine." + }, + { + "input": "Concept: NETHERLANDS (Western Europe)", + "output": "Affiliate Realms described as a country in Western Europe, bordering the North Sea, between Belgium and Germany." + }, + { + "input": "Concept: Nuclear Receptor Co-Repressors (Biologically Active Substance)", + "output": "Amino Acid, Peptide, or Protein described as co-repressor proteins that bind to inactive NUCLEAR RECEPTORS and mediate GENE SILENCING." + }, + { + "input": "Concept: cellularization cleavage furrow (Cell Component)", + "output": "something described as a plasma membrane invagination at the site of separation of a multi-nucleate cell or syncytium into individual cells." + }, + { + "input": "Concept: Sulcus sinus transversi (Anatomical line)", + "output": "Skull groove described as skull groove, each instance of which is a wide groove that passes horizontally, laterally, and anteriorly from some internal occipital protuberance to some parietal bone, where it becomes continuous with the sulcus of some sigmoid sinus; it lodges some transverse sinus." + }, + { + "input": "Concept: Prior Evaluation: Diagnosis (ACC-AHA Measure)", + "output": "ACC-AHA Measure described as diagnosis given based on the previous evaluation of the chief complaint." + }, + { + "input": "Concept: corticotropin hormone secreting cell differentiation (Cell Function)", + "output": "Cell Differentiation process described as the process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a corticotropic hormone secreting cell. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin." + }, + { + "input": "Concept: aggregation during fruiting body development (cellular response to starvation)", + "output": "cellular response to starvation described as the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug." + }, + { + "input": "Concept: N26-(Hexadecanoyl-gamma-glutamyle)-(34-arginine)glucagon-like-peptide-1-(7-37)-peptide (Glucagon-like peptide-1 (GLP-1) analogues)", + "output": "Hormone described as a long-acting, fatty acylated glucagon-like peptide-1 (GLP-1) analog administered subcutaneously, with antihyperglycemic activity. Liraglutide's prolonged action and half-life of 11-15 hours are attributed to the attachment of the fatty acid palmitic acid to GLP-1 that reversibly binds to albumin. Albumin binding protects liraglutide from immediate degradation and elimination and causes GLP-1 to be released from abumin in a slow and consistent manner. This agent may cause thyroid C-cell tumors and increases the risk of acute pancreatitis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C82239\" active clinical trials using this agent." + }, + { + "input": "Concept: FIGO Stage IC3 (FIGO Stage IC)", + "output": "FIGO Stage IC described as a FIGO stage term that applies to ovarian cancer, fallopian tube cancer, and primary peritoneal cancer. It refers to cancer with malignant cells in the ascites or peritoneal washings." + }, + { + "input": "Concept: macular (Spatial Concept)", + "output": "something described as an opaque spot on the cornea" + }, + { + "input": "Concept: rockerbottom foot (Congenital valgus deformity of foot)", + "output": "Congenital Abnormality described as the presence of both a prominent heel and a convex contour of the sole." + }, + { + "input": "Concept: Neural Pathway (Nervous system structure)", + "output": "something described as the route in which a nerve impulse travels through a series of linked axons to connect different regions within the central nervous system or to convey information from the peripheral nervous system to the brain." + }, + { + "input": "Concept: Grade 2 Colonic perforation (Colonic Perforation, CTCAE 5)", + "output": "Finding described as invasive intervention not indicated" + }, + { + "input": "Concept: Undertaking a single task (CHAPTER 2 GENERAL TASKS AND DEMANDS)", + "output": "CHAPTER 2 GENERAL TASKS AND DEMANDS described as carrying out simple or complex and coordinated actions related to the mental and physical components of a single task, such as initiating a task, organizing time, space and materials for a task, pacing task performance, and carrying out, completing, and sustaining a task." + }, + { + "input": "Concept: Locally Advanced Alveolar Soft Part Sarcoma (Locally Advanced Soft Tissue Sarcoma)", + "output": "something described as alveolar soft part sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes." + }, + { + "input": "Concept: somatic afferent nerve (Body Part, Organ, or Organ Component)", + "output": "something described as pertaining to those nerve fibers which conduct impulses to the central nervous system from cutaneous endings for pain, temperature, and touch (exteroceptive) and from muscles, tendons, and joints (proprioceptive)." + }, + { + "input": "Concept: Dihydrolipoamide: NAD+ oxidoreductase (Enzyme)", + "output": "Flavoproteins described as a flavoprotein containing oxidoreductase that catalyzes the reduction of lipoamide by NADH to yield dihydrolipoamide and NAD+. The enzyme is a component of several MULTIENZYME COMPLEXES." + }, + { + "input": "Concept: Interviewing (Activity)", + "output": "Data Collection described as works about conversations with an individual or individuals held in order to obtain information about their background and other personal biographical data, their attitudes and opinions, etc. It includes works about school admission or job interviews." + }, + { + "input": "Concept: Advanced Trauma Life Support Care (Emergency medical service)", + "output": "Health Care Activity described as the initial life support care of the severely injured patient." + }, + { + "input": "Concept: Powder and Solvent for Nebulizer Solution Dosage Form (Biomedical or Dental Material)", + "output": "Combined Dosage Form described as powder (including freeze-dried powder) and solvent intended for the preparation of a nebuliser solution by dissolving the powder in the solvent." + }, + { + "input": "Concept: adenine import across plasma membrane (Cell Function)", + "output": "import across plasma membrane described as the directed movement of adenine from outside of a cell, across the plasma membrane and into the cytosol." + }, + { + "input": "Concept: Neonatal Resuscitation (Resuscitation procedure)", + "output": "Therapeutic or Preventive Procedure described as measures applied for the restoration of life to a newborn." + }, + { + "input": "Concept: Encephalopathy NOS (Other conditions of brain)", + "output": "Other conditions of brain described as diffuse disease of the brain that alters function and/or structure of the brain and is characterized by an altered mental state." + }, + { + "input": "Concept: negative regulation of cellulosome assembly (negative regulation of organelle assembly)", + "output": "regulation of cellulosome assembly described as any process that stops, prevents or reduces the frequency, rate or extent of cellulosome assembly." + }, + { + "input": "Concept: Wall of biventricular part of heart (Region of wall of heart)", + "output": "Body Location or Region described as wall of heart which has as its parts the walls of the right and left ventricles that surrounds its cavities and is attached to the fibrous rings of heart." + }, + { + "input": "Concept: Osteoconduction (Organ or Tissue Function)", + "output": "Organ or Tissue Function described as a physiological phenomenon of BONE TRANSPLANTATION, whereby the new graft matrix configures a scaffold on which cells in the recipient form new bone." + }, + { + "input": "Concept: Person Race Code (Race Code)", + "output": "Race Code described as a coded value specifying a self-declared racial origination, independent of ethnic origination. EXAMPLE(S): For the National Cancer Institute (NCI), this code is based on Office of Management & Budget (OMB) approved categories." + }, + { + "input": "Concept: Cytochrome P450 Family 1 (Amino Acid, Peptide, or Protein)", + "output": "something described as a cytochrome P450 enzyme family whose members function primarily in the metabolism of XENOBIOTICS, including drugs and POLYCYCLIC AROMATIC HYDROCARBONS." + }, + { + "input": "Concept: regulation of establishment of protein localization to telomere (Physiologic Function)", + "output": "regulation of establishment of protein localization to chromosome described as any process that modulates the frequency, rate or extent of the directed movement of a protein to a specific location in the telomeric region of a chromosome." + }, + { + "input": "Concept: Deliverable Volume/Fill Volume (Functional Concept)", + "output": "Functional Concept described as tests designed to provide assurance that the liquids will, when transferred from the original container, deliver the volume of dosage form that is declared on the label of the article." + }, + { + "input": "Concept: regulation of t-circle formation (regulation of telomere maintenance)", + "output": "Genetic Function described as any process that modulates the frequency, rate or extent of t-circle formation." + }, + { + "input": "Concept: Participant Exposed to Secondhand Smoke (Finding)", + "output": "something described as the individual was exposed to secondhand smoke." + }, + { + "input": "Concept: DECAPITATION (Site specific injuries NEC)", + "output": "Injury or Poisoning described as a method of euthanasia whereby a subject's head is removed from the body." + }, + { + "input": "Concept: positive regulation of removal of superoxide radicals (positive regulation of cellular response to oxidative stress)", + "output": "positive regulation of reactive oxygen species metabolic process described as any process that activates or increases the frequency, rate or extent of removal of superoxide radicals." + }, + { + "input": "Concept: negative regulation of mammary gland development in males by androgen receptor signaling pathway (Molecular Function)", + "output": "something described as any process that decreases the rate or extent of mammary gland development in the male by an androgen binding to its receptor, causing a change in state or activity of a cell." + }, + { + "input": "Concept: TUBE, DOUBLE LUMEN FOR INTESTINAL DECOMPRESSION AND/OR INTUBATION (Medical Device)", + "output": "Medical Device described as a gastrointestinal tube and accessories is a device that consists of flexible or semi-rigid tubing used for instilling fluids into, withdrawing fluids from, splinting, or suppressing bleeding of the alimentary tract. This device may incorporate an integral inflatable balloon for retention or hemostasis. This generic type of device includes the hemostatic bag, irrigation and aspiration catheter (gastric, colonic, etc.), rectal catheter, sterile infant gavage set, gastrointestinal string and tubes to locate internal bleeding, double lumen tube for intestinal decompression or intubation, feeding tube, gastroenterostomy tube, Levine tube, nasogastric tube, single lumen tube with mercury weight balloon for intestinal intubation or decompression, and gastro-urological irrigation tray (for gastrological use)." + }, + { + "input": "Concept: Perioperative positioning injury (Traumatic injury)", + "output": "Traumatic injury described as damages from operative process positioning" + }, + { + "input": "Concept: DNA-directed RNA polymerase II, core complex assembly (cellular protein-containing complex assembly)", + "output": "something described as the aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase II core complex." + }, + { + "input": "Concept: maintenance of floral meristem identity (maintenance of meristem identity)", + "output": "Physiologic Function described as the process in which an organism retains a population of floral meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." + }, + { + "input": "Concept: CARDIOVASCULAR (Anatomy Qualifier)", + "output": "something described as pertaining to the heart or blood vessels." + }, + { + "input": "Concept: Medical Record, Problem-Oriented (Assessment scales Pa-Ra)", + "output": "Assessment scales Pa-Ra described as a system of record keeping in which a list of the patient's problems is made and all history, physical findings, laboratory data, etc. pertinent to each problem are placed under that heading." + }, + { + "input": "Concept: Anterior Pituitary Gland Neoplasm (Pituitary Neoplasms)", + "output": "Central Nervous System Neoplasms, Primary described as a neoplasm arising from the anterior lobe of the pituitary gland. The vast majority are adenomas." + }, + { + "input": "Concept: Orofaciodigital syndrome type 13 (Disease or Syndrome)", + "output": "Orofaciodigital Syndromes described as a rare subtype of orofaciodigital syndrome, with sporadic occurrence and characteristics of cardiac (mitral and tricuspid valve dysplasia) and neuropsychiatric manifestations (epilepsy, depression), in addition to oral, facial and digital malformations (lingual hamartomas, cleft lip, and brachydactyly, clinodactyly, syndactyly of hands and feet). Leukoaraiosis on brain MRI examination is also associated." + }, + { + "input": "Concept: Factor VIII Deficiency (Hemorrhagic Disorders)", + "output": "Coagulation Protein Disorders described as the classic hemophilia resulting from a deficiency of factor VIII. It is an inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhage." + }, + { + "input": "Concept: Effervescent Powder and Powder for Oral Suspension (Biomedical or Dental Material)", + "output": "something described as effervescent powder and powder intended for the preparation of an oral suspension by dispersing the effervescent powder and the powder in the specified liquid. Comment: Active ingredient(s) may be found in both the effervescent powder and the powder, or in only one of the components." + }, + { + "input": "Concept: PolyI:PolyC with Poly-L-Lysine Stabilizer (Immunologic Adjuvants)", + "output": "Nucleic Acid, Nucleoside, or Nucleotide described as a synthetic complex of carboxymethylcellulose, polyinosinic-polycytidylic acid, and poly-L-lysine double-stranded RNA. Poly ICLC may stimulate the release of cytotoxic cytokines and, by inducing interferon-gamma production, may increase the tumoricidal activities of various immunohematopoietic cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1198\" active clinical trials using this agent." + }, + { + "input": "Concept: Nasal Cavity and Ethmoid Sinus Cancer Clinical Distant Metastasis TNM Finding v7 (Nasal Cavity and Ethmoid Sinus Cancer Clinical TNM Finding v7)", + "output": "Nasal Cavity and Ethmoid Sinus Cancer Clinical TNM Finding v7 described as a clinical finding about one or more characteristics of nasal cavity and ethmoid sinus cancer, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases." + }, + { + "input": "Concept: Blood Cell Washer Sets (Medical Device)", + "output": "Medical Device described as combinations of preassembled devices designed for use in blood cell washers. These sets typically include plastic tubing, filters (e.g., clot, debris), connectors, and bags (e.g., red blood cell, waste); some sets also include a disposable bowl for the processing solution (e.g., saline). Dedicated disposable blood cell washer sets are available as a disposable component of cell washers for use by blood banks and transfusion centers to improve the safety of blood transfusions; others sets are intended for autotransfusion units used during surgery and/or for treatment of trauma." + }, + { + "input": "Concept: Immunogenicity, Vaccine (Biologic Function)", + "output": "something described as the capacity of VACCINES to stimulate the ADAPTIVE IMMUNE RESPONSE to produce antibodies and antigen-specific T-CELL responses." + }, + { + "input": "Concept: Disposable Equipment (Equipment and Supplies)", + "output": "something described as apparatus, devices, or supplies intended for one-time or temporary use." + }, + { + "input": "Concept: B-Cell CLL-Lymphoma 2 Gene Rearrangement (Gene Rearrangement Abnormality)", + "output": "something described as a molecular abnormality indicating rearrangement of the BCL2 gene." + }, + { + "input": "Concept: Total Dietary Lipid (Bioactive Food Component)", + "output": "Food described as a class of food constituents, also known as fats and oils, that serve as a source of energy and essential fatty acids in animals. The major components of lipids are fatty acids, triglycerides, phospholipids, glycolipids, sphingolipids, steroids (cholesterol), and lipoproteins." + }, + { + "input": "Concept: ATYPICAL (General Qualifier)", + "output": "something described as varying from the norm; not conformable to the type." + }, + { + "input": "Concept: Hip Retractor Kits (Surgical Retractor Kits, Joint)", + "output": "something described as joint tissue surgery retractor kits designed for use during procedures involving the hip. The retractor kits permit the separation of tissues (e.g., periosteal) in the hip joint, exposing and providing access to other tissues, bones, or structures of the joint. These kits typically consist of a collection of several instruments (e.g., a hip elevator) including retractors (e.g., straight, curved, narrow) of different sizes; each one is appropriate for retraction of one of the anatomic and associated structures of the hip joint when used together or independently. Hip joint retractor kits provide assistance to the surgeon during orthopedic procedures, including minimally invasive hip surgery." + }, + { + "input": "Concept: WEST NILE VIRUS (Flavivirus)", + "output": "Virus described as transmitted by Culex spp mosquitos; agent of emerging disease in North America." + }, + { + "input": "Concept: UPDRS - Symptomatic Orthostasis: Pulse, Standing (Intellectual Product)", + "output": "something described as unified Parkinson's Disease Rating Scale - Pulse: Standing." + }, + { + "input": "Concept: Hypoacusis unilateral (hearing impairment)", + "output": "Unilateral clinical finding described as a unilateral absence of sensory perception of sound." + }, + { + "input": "Concept: Microbiology, Water (Ecology)", + "output": "Ecology described as the presence of bacteria, viruses, and fungi in water. This term is not restricted to pathogenic organisms." + }, + { + "input": "Concept: Past Seven Days Bruise Easily (Intellectual Product)", + "output": "something described as a question about whether an individual bruised easily over the last seven days." + }, + { + "input": "Concept: 1: 189509828-189513060 (Chromosome 1 Physical Location)", + "output": "Chromosome 1 Physical Location described as physical location of RGS2_Gene" + }, + { + "input": "Concept: Cell physiology (Physiological Phenomena)", + "output": "Portuguese translation of the Medical Subject Headings described as cellular processes, properties, and characteristics." + }, + { + "input": "Concept: High risk (Adjectival modifier)", + "output": "Adjectival modifier described as high risk of sudden death due to cardiovascular events based on Duke Treadmill Score <10" + }, + { + "input": "Concept: fibrinogen complex location (protein-containing complex)", + "output": "protein-containing complex described as a highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds." + }, + { + "input": "Concept: Structures, Cell Nucleus (Cell Component)", + "output": "Organelle part described as structures that are part of or contained in the CELL NUCLEUS." + }, + { + "input": "Concept: mammary gland fat development (Adipogenesis)", + "output": "something described as the progression of the mammary gland fat over time, from its formation to the mature structure. The mammary fat is an adipose structure in the gland that is invaded by the mammary ducts." + }, + { + "input": "Concept: dextrin alpha-glucosidase activity (alpha-glucosidase activity)", + "output": "Molecular Function described as catalysis of the reaction: dextrin + H2O = alpha-D-glucose." + }, + { + "input": "Concept: Male Prepuce (penis)", + "output": "Skin of penis described as a fold of skin covering the tip of the penis." + }, + { + "input": "Concept: SDTM-CVLVRSEV (Unused Subset Concept)", + "output": "something described as terminology associated with the cardiac valvular regurgitation severity codelist of the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: XRN2 wt Allele (Gene or Genome)", + "output": "Gene or Genome described as human XRN2 wild-type allele is located within 20p11.2-p11.1 and is approximately 87 kb in length. This allele, which encodes 5'-3' exoribonuclease 2 protein, plays a role in both the modulation RNA metabolism and stabilization of mRNA." + }, + { + "input": "Concept: CERULOPLASMIN, FITC, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)", + "output": "something described as a ceruloplasmin immunological test system is a device that consists of the reagents used to measure by immunochemical techniques the ceruloplasmin (copper-transporting serum protein) in serum, other body fluids, or tissues. Measurements of ceruloplasmin aid in the diagnosis of copper metabolism disorders." + }, + { + "input": "Concept: mexicanas, Leishmania leishmania (Eukaryote)", + "output": "Eukaryote described as a species of parasitic trypanosomatid protozoa in the family Trypanosomatidae. L. mexicana is endemic in South and Central America and causes the mildest form of leishmaniasis." + }, + { + "input": "Concept: Contracture of the proximal interphalangeal joint of the 3rd toe (Flexion contracture of 3rd toe)", + "output": "Anatomical Abnormality described as the proximal interphalangeal joint of the 3rd toe cannot be straightened actively or passively." + }, + { + "input": "Concept: polyA stuttering (Polyadenylation)", + "output": "Molecular Function described as polyadenylation of viral mRNA through a polymerase stuttering mechanism. The stop signal present at the end of each gene comprises a stretch of uridine on which the viral polymerase acquires a stuttering behavior: after each adenine inserted, the polymerase moves back one nucleotide along with the mRNA. It resumes transcription adding a new adenine, then again moves back, thereby producing a polyA tail." + }, + { + "input": "Concept: beta-ureidopropionase activity (Molecular Function)", + "output": "something described as catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3." + }, + { + "input": "Concept: Analyzers, Physiologic, Neuromuscular Function, Functional Age (Medical Device)", + "output": "something described as neuromuscular function physiologic analyzers designed to evaluate several biological measures (i.e., biomarkers) that assess biological states that are essential for activities of daily living, thus characterizing the functional age of a person. The analyzers evaluate both neurologic (e.g., memory, reaction times) and physical conditions (e.g., hearing, vision, tactile, lung functions) and compare the results with standard values from healthy people adjusted for sex and age to show the biomarkers' decline in a given person. The set of biomarkers (typically about 12) chosen is related to those conditions that are involved in mental and physical activities that better characterize normal day-to-day living. These analyzers typically consist of a set of measuring instruments and transducers (e.g., headphones, lenses, vibrometers, spirometers) and a panel with push buttons to evaluate the physiologic parameters and reaction times. The analyzer also includes a computer with appropriate software to calculate and provide the results including a value of the functional age for comparison with the chronological age. Functional-age physiologic analyzers are used to assess the status of a person, facilitating the development of programs for lifestyle, diet, exercise, and/or other therapeutic (e.g., use of assistive devices) actions needed to improve daily living of aging people." + }, + { + "input": "Concept: oripavine 6-O-demethylase activity (2-oxoglutarate-dependent dioxygenase activity)", + "output": "2-oxoglutarate-dependent dioxygenase activity described as catalysis of the reaction: oripavine + 2-oxoglutarate + O2 <=> morphinone + formaldehyde + succinate + carbon dioxide." + }, + { + "input": "Concept: Swelling behind knee (Baker's cyst) present (Finding)", + "output": "Finding described as baker's cyst: Popliteal cysts resulting from a synovial effusion of the knee. A communication exists between the knee joint and the semimembranosus-gastrocnemial bursa beneath the medial head of the gastrocnemius muscle. These cysts may rupture and result in pain, swelling and erythema of the calf (pseudothrombophlebitis)." + }, + { + "input": "Concept: Recurrent Burkitt Leukemia (Recurrent Lymphoproliferative Disorder)", + "output": "Recurrent Acute Leukemia described as the reemergence of Burkitt leukemia after a period of remission." + }, + { + "input": "Concept: indiana (Region of United States of America)", + "output": "Geographic Area described as state bounded on the north by Lake Michigan and Michigan, on the east by Ohio, on the south by Kentucky, and on the west by Illinois." + }, + { + "input": "Concept: negative regulation of adult somatic muscle development (regulation of adult somatic muscle development)", + "output": "regulation of adult somatic muscle development described as any process that decreases the rate, frequency or extent of adult somatic muscle development." + }, + { + "input": "Concept: measuring (General Qualifier)", + "output": "Beginning described as having been determined by measurement." + }, + { + "input": "Concept: Calcified ovarian cyst (Ovarian Cysts)", + "output": "something described as a cyst of the ovary that exhibits deposition of calcium salts." + }, + { + "input": "Concept: MX (Geographic Area)", + "output": "North America described as a country in NORTH AMERICA, bordering the Caribbean Sea and the Gulf of Mexico, between BELIZE and the UNITED STATES, and bordering the North Pacific Ocean, between Guatemala and the UNITED STATES." + }, + { + "input": "Concept: Social interaction alteration (Negative Diagnosis And Outcome)", + "output": "Social interaction finding described as inadequate quantity or quality of personal relations" + }, + { + "input": "Concept: NCCN-FACT-FPSI 17 Version 2 - I Have Bone Pain (NCCN-FACT-FPSI 17 Version 2 Questionnaire Question)", + "output": "Intellectual Product described as national Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Prostate Symptom Index 17 Version 2 - I have bone pain." + }, + { + "input": "Concept: Not Known if NRAS Mutation Analysis Was Performed (Finding)", + "output": "Not Known if Mutation Analysis Was Performed described as an indication that it is not known whether NRAS rearrangement analysis was performed during the study." + }, + { + "input": "Concept: Elevated circulating catecholamine level (Finding)", + "output": "Finding described as an abnormal increase in catecholamine concentration in the blood." + }, + { + "input": "Concept: 5q31-q32 (Chromosome band)", + "output": "Chromosome band described as a chromosome band present on 5q" + }, + { + "input": "Concept: Maxillary Sinus Cancer Clinical TNM Finding v7 (Finding)", + "output": "Maxillary Sinus Cancer TNM Finding v7 described as a clinical finding about one or more characteristics of maxillary sinus cancer, following the rules of the TNM AJCC v7 classification system. The assessment is based on inspection and palpation, including examination of the orbits, nasal and oral cavities, and nasopharynx, and neurologic examination of the cranial nerves. Nasal endoscopy with rigid or fiberoptic flexible instruments is recommended. Radiologic assessment with magnetic resonance imaging (MRI) or computed tomography (CT) is mandatory for accurate pretreatment staging of malignant tumors of the sinuses." + }, + { + "input": "Concept: Paced Ventricular Single Beat QRS Duration (Quantitative Concept)", + "output": "Quantitative Concept described as an electrocardiographic interval measured from the onset of the paced QRS complex to the offset of the QRS complex of a single beat utilizing one or more leads." + }, + { + "input": "Concept: Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis Syndrome (Chronic disease of immune structure)", + "output": "Lymphatic system disorders NEC described as an autoinflammatory syndrome of childhood which often resolves in adolescence, and is characterized by periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis. The fever cycle generally occurs every three to five weeks, and during the interim periods the child appears healthy; diagnosis is exclusionary." + }, + { + "input": "Concept: Vulvar Paget's Disease (Carcinoma in situ of female genital organ)", + "output": "Vulval neoplasms malignant described as an uncommon intraepithelial malignant neoplasm of eccrine or apocrine origin, arising from the vulva. It usually affects post-menopausal women. In approximately 10-20% of the cases there is an associated anorectal, or urothelial carcinoma or a skin appendage adenocarcinoma identified. It presents as a red, eczematous lesion. Microscopically, it is characterized by the presence of the typical Paget cells which are large, round cells with abundant cytoplasm and prominent nuclei. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C4027\" active clinical trials using this agent." + }, + { + "input": "Concept: oxazole or thiazole formation (oxazole or thiazole metabolic process)", + "output": "Molecular Function described as the chemical reactions and pathways resulting in the formation of oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position." + }, + { + "input": "Concept: Disorder caused by exposure to radiation (Disease or Syndrome)", + "output": "GENERAL CONVENIENCE DISEASE TERMS described as a non-neoplastic or neoplastic disorder which results from exposure to radiation. Examples of non-neoplastic disorders include dermatitis, enteritis, stomatitis, pneumonitis, and cerebritis. Examples of neoplastic disorders include myelodysplastic syndromes, leukemias, and sarcomas." + }, + { + "input": "Concept: Stage II Colon Cancer AJCC v7 (Neoplastic Process)", + "output": "Colon Cancer by AJCC v7 Stage described as stage II includes: IIA (T3, N0, M0); IIB (T4a, N0, M0); IIC (T4b, N0, M0). T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor penetrates to the surface of the visceral peritoneum. T4b: Tumor directly invades or is adherent to other organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis." + }, + { + "input": "Concept: citrate test (Chemical procedure)", + "output": "SPECIFIC SUBSTANCE CHEMISTRY TESTS described as the determination of the amount of citrate present in a sample." + }, + { + "input": "Concept: Lymph gland, NOS (Procedures on Blood and Blood-forming Organs)", + "output": "Lymphatic System described as they are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system." + }, + { + "input": "Concept: endoplasmic reticulum tubular network organisation (Cell Function)", + "output": "something described as a process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network. The ER tubular network is the ER part that that has membranes with high curvature in cross-section." + }, + { + "input": "Concept: Anson Unit (Quantitative Concept)", + "output": "something described as a unit of enzyme concentration which is defined as the amount of enzyme that can digest urea-denatured hemoglobin at the same initial rate as one milliequivalent of tyrosine at standard conditions." + }, + { + "input": "Concept: presynaptic terminal (Cell Component)", + "output": "cellular anatomical entity described as the part of a synapse that is part of the presynaptic cell." + }, + { + "input": "Concept: 14,39-Dioxabicyclo(33.3.1)nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid, 33-((3-amino-3,6-dideoxy-beta-D-mannopyranosyl)oxy)-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-, (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)- (Macrolides)", + "output": "something described as a drug used in the treatment of infections caused by fungi. It is a type of antifungal." + }, + { + "input": "Concept: AVL01-List A Recall 5 Word 2 (Intellectual Product)", + "output": "something described as auditory Verbal Learning Test Version A - List A, Recall 5, Word 2." + }, + { + "input": "Concept: Anti-HGF Monoclonal Antibody TAK-701 (Monoclonal Antibodies)", + "output": "Antineoplastic Antibody described as a humanized monoclonal antibody directed against human hepatocyte growth factor (HGF) with potential antineoplastic activity. Anti-HGF monoclonal antibody TAK-701 binds to the soluble ligand HGF, preventing HGF binding to and activation of the HGF receptor c-Met and so the activation of the c-Met signaling pathway; this may result in the induction of cell death in c-Met-expressing tumor cells. c-Met, a receptor tyrosine kinase overexpressed or mutated in a variety of tumor cell types, plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C81939\" active clinical trials using this agent." + }, + { + "input": "Concept: IGFALS Measurement (Laboratory Procedure)", + "output": "something described as a measurement of the acid labile subunit in a biological specimen." + }, + { + "input": "Concept: MGC104659 (Gene or Genome)", + "output": "something described as human MXD1 wild-type allele is located within 2p13-p12 and is approximately 28 kb in length. This allele, which encodes MAD protein, plays a role in transcriptional repression." + }, + { + "input": "Concept: Undefined flower essence narrative required (Flower Essences)", + "output": "Flower Essences described as any elsewhere undefined flower essence, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com." + }, + { + "input": "Concept: Benign concentric annular macular dystrophy (Disease or Syndrome)", + "output": "something described as a progressive autosomal dominant macular dystrophy with characteristics of parafoveal hypopigmentation followed by a retinitis pigmentosa-like phenotype (nyctalopia and peripheral vision loss) with a bull's eye configuration." + }, + { + "input": "Concept: FAC018-I Am Satisfied With My Sex Life (Intellectual Product)", + "output": "something described as functional Assessment of Cancer Therapy-Lymphoma Version 4 - Social/Family Well-Being: I am satisfied with my sex life." + }, + { + "input": "Concept: Agreement Rating Score 6 (Finding)", + "output": "something described as a subjective score of 6 on a scale that ranges from 1: Strongly Disagree to 6: Strongly Agree." + }, + { + "input": "Concept: STREPTOCOCCUS URINALIS (Bacterium)", + "output": "Streptococcus described as any bacterial organism that can be assigned to the species Streptococcus urinalis." + }, + { + "input": "Concept: Ureteropelvic junction obstruction NOS (Urinary Bladder)", + "output": "Ureteric neuromuscular incoordination described as complete or partial blockage of the ureter at the point where it enters the kidney." + }, + { + "input": "Concept: Site of Fetal Membrane Rupture (Finding)", + "output": "Placental finding described as the space that occupies the distance between the shortest free edge of the fetal membranes and the disc edge." + }, + { + "input": "Concept: Serenoa (Arecaceae)", + "output": "Arecaceae described as a plant genus in the family ARECACEAE, order Arecales, subclass Arecidae. The fruit or the extract (Permixon) is used for PROSTATIC HYPERPLASIA." + }, + { + "input": "Concept: GMSS0108 (Intellectual Product)", + "output": "GMSS Version Type 1 Diabetes Questionnaire Question described as the Glucose Monitoring System Satisfaction Survey Version: Type 1 Diabetes - My current monitor: Helps me feel less restricted by diabetes." + }, + { + "input": "Concept: Prostate Specific G Protein-Coupled Receptor (Amino Acid, Peptide, or Protein)", + "output": "something described as olfactory receptor 51E2 (320 aa, ~35 kDa) is encoded by the human OR51E2 gene. This protein may play a role in binding odorant molecules." + }, + { + "input": "Concept: Schedule (Intellectual Product)", + "output": "Document type described as in a clinical setting, the step-by-step plan for how patients are to be treated; for example, the drug or type of radiation therapy that is to be given, the method by which it is to be given, the amount of time between courses, and the total length of treatment." + }, + { + "input": "Concept: dense core granule docking (Cell Function)", + "output": "something described as the initial attachment of a dense core granule membrane to the plasma membrane." + }, + { + "input": "Concept: Symptom aggravating factors (Finding)", + "output": "Symptom aggravating factors described as an aggravating factor is defined as an external factor that leads to a sign or symptom that is already present getting worse or becoming more severe. []" + }, + { + "input": "Concept: Breast Cancers, Inflammatory (Invasive carcinoma of breast)", + "output": "Mammary Neoplasms described as a type of breast cancer in which the breast looks red and swollen and feels warm. The skin of the breast may also show the pitted appearance called peau d'orange (like the skin of an orange). The redness and warmth occur because the cancer cells block the lymph vessels in the skin." + }, + { + "input": "Concept: 3-Keto-Erythromycins (Macrolides)", + "output": "Organic Chemical described as compounds based on ERYTHROMYCIN with the 3-cladinose replaced by a ketone. They bind the 23S part of 70S bacterial RIBOSOMES." + }, + { + "input": "Concept: day*mg/mL/(mg/g) (Quantitative Concept)", + "output": "Quantitative Concept described as days times milligrams per milliliter (area under the curve), divided by milligrams per gram (dose normalized by body weight)." + }, + { + "input": "Concept: Arizona (Southwestern United States)", + "output": "Southwestern United States described as state of the UNITED STATES OF AMERICA bounded on the east by New Mexico, on the north by Utah, on the west by Nevada and California, and on the south by Mexico." + }, + { + "input": "Concept: high-density lipoprotein particle binding (Molecular Function)", + "output": "something described as interacting selectively and non-covalently with high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE." + }, + { + "input": "Concept: Percentile (property) (Property)", + "output": "Statistical Technique described as any of the 99 numbered points that divide an ordered set of scores into 100 parts each of which contains one-hundredth of the total." + }, + { + "input": "Concept: exogenous drug catabolism (Molecular Function)", + "output": "Molecular Function described as the chemical reactions and pathways resulting in the breakdown of a drug that has originated externally to the cell or organism." + }, + { + "input": "Concept: Image Digitization Systems, Microscopy, Confocal Scanning Laser (Image Digitization Systems, Microscopy)", + "output": "something described as systems designed to process, display, and store images taken by a confocal scanning laser microscope. These systems typically consist of a laser light source, an image display, and a computerized processor that controls the light source, the image processing, and the display monitor. The system is usually attached to a confocal laser optical microscope that may be used externally (i.e., on the skin) or in endoscopic procedures, either as an integral component of an endoscope or operating through the working channel of a video endoscope. Endoscopic confocal scanning laser microscopy image systems are used mainly to observe the structure of both normal and living cancer cells and may assist in in-vivo histologic diagnosis (e.g., of the gastrointestinal tract) without the need for biopsy." + }, + { + "input": "Concept: Collagen type XIII (Amino Acid, Peptide, or Protein)", + "output": "something described as a non-fibrillar collagen found as a ubiquitously expressed membrane- associated protein. Type XIII collagen contains both collagenous and non-collagenous domains along with a transmembrane domain within its N-terminal region." + }, + { + "input": "Concept: taxes (distribution of wealth and income control)", + "output": "distribution of wealth and income control described as governmental levies on property, inheritance, gifts, etc." + }, + { + "input": "Concept: parents (Nuclear Family)", + "output": "Ancestor described as maternal and/or Paternal; should only be used if the specific result cannot be reported." + }, + { + "input": "Concept: h.mol/l/(kg/m2) (Quantitative Concept)", + "output": "Quantitative Concept described as hours times moles per liter (area under the curve), divided by kilograms per meter squared (body mass index)." + }, + { + "input": "Concept: EPDS (Intellectual Product)", + "output": "Assessment scales Di-Ga described as a standardized 10-item self-report scale that was developed by Cox et al 1987 to assist health professionals in identifying possible symptoms of depression in the postnatal period. The instrument utilizes a 4-point symptom rating scale to allow women to grade their experiences over the past seven days." + }, + { + "input": "Concept: KAT2B (Gene or Genome)", + "output": "something described as this gene is involved in histone and nucleosome remodeling and transcriptional regulation." + }, + { + "input": "Concept: protein localization to cytoplasmic microtubule (protein localization to microtubule)", + "output": "protein localization to microtubule described as a process in which a protein is transported to, or maintained in, a location within a cytoplasmic microtubule." + }, + { + "input": "Concept: Incyclinide (Matrix Metalloproteinase Inhibitors)", + "output": "something described as a chemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2454\" active clinical trials using this agent." + }, + { + "input": "Concept: Family cichlidae - cichlid (Fish)", + "output": "Fishes described as common name for perch-like fish of the family Cichlidae, belonging to the suborder Labroidei, order PERCIFORMES." + }, + { + "input": "Concept: Oculotrichodysplasia (Hereditary disorder of the integument)", + "output": "Digestive system hereditary disorder described as this disease has characteristics of retinitis pigmentosa, trichodysplasia, dental anomalies, and onychodysplasia. It has been described in two siblings (brother and sister) born to first cousin parents. Transmission appears to be autosomal recessive." + }, + { + "input": "Concept: Appendix: Excision (Procedures on Appendix)", + "output": "Abdominal Surgical Procedure described as surgical removal of the vermiform appendix." + }, + { + "input": "Concept: huBC1-huIL12 fusion protein AS1409 (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as an immunoconjugate consisting of the anti-tumor cytokine interleukin-12 (IL-12) fused to the tumor-targeting antibody BC1 with potential immunostimulatory and antineoplastic activities. The antibody moiety of huBC1-huIL12 fusion protein AS1409 binds to the human fibronectin splice variant ED-B, delivering IL-12 directly to the tumor vasculature; tumor vasculature-targeted IL-12 initiates localized immune cascade responses and exhibits cytotoxic and anti-angiogenic activity while minimizing the systemic side effects of IL-12. The human fibronectin splice variant ED-B is over-expressed in the extracellular matrix and blood vessels of tumor tissues." + }, + { + "input": "Concept: A. temporalis anterior (Structure of temporal branch of middle cerebral artery)", + "output": "Structure of middle cerebral artery described as a branch of the middle cerebral artery that supplies blood to the anterior part of the temporal lobe." + }, + { + "input": "Concept: 6-[(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]- 3-Pyridinecarboxylic Acid, Ethyl Ester (Pharmacologic Substance)", + "output": "Retinoid [EPC] described as a synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29487\" active clinical trials using this agent." + }, + { + "input": "Concept: maxilla; hyperplasia (Anomaly of jaw size)", + "output": "Major anomaly of jaw size described as abnormally increased dimension of the maxilla, especially relative to the mandible, resulting in a malocclusion or malalignment between the upper and lower teeth or in anterior positioning of the nasal base, increased convexity of the face, increased nasolabial angle, or increased width (transverse dimension of the maxilla. []" + }, + { + "input": "Concept: cryptogenic (General adjectival modifier)", + "output": "Functional Concept described as describes a disease of unknown cause." + }, + { + "input": "Concept: Tissue Plasminogen Activator Antigen (Laboratory Procedure)", + "output": "Laboratory Procedure described as the determination of the amount of tissue plasminogen activator antigen present in a sample." + }, + { + "input": "Concept: heart size (Heart)", + "output": "something described as physical dimensions of the heart, including the shape." + }, + { + "input": "Concept: Cornification, function (Apoptosis)", + "output": "Cell Function described as a type of programmed cell death that occurs in the epidermis, morphologically and biochemically distinct from apoptosis. It leads to the formation of corneocytes, i.e. dead keratinocytes containing an amalgam of specific proteins (e.g., keratin, loricrin, SPR and involucrin) and lipids (e.g., fatty acids and ceramides), which are necessary for the function of the cornified skin layer (mechanical resistance, elasticity, water repellence and structural stability)." + }, + { + "input": "Concept: MAPKAPK2 wt Allele (MAPKAPK2 gene)", + "output": "MAPKAPK2 gene described as human MAPKAPK2 wild-type allele is located in the vicinity of 1q32 and is approximately 49 kb in length. This allele, which encodes MAP kinase-activated protein kinase 2 protein, plays a role in MAPK-dependent signaling." + }, + { + "input": "Concept: DIGITOXIN CONTROL SERUM, RIA (Indicator, Reagent, or Diagnostic Aid)", + "output": "Indicator, Reagent, or Diagnostic Aid described as a clinical toxicology control material is a device intended to provide an estimation of the precision of a device test system and to detect and monitor systematic deviations from accuracy resulting from reagent or instrument defects. This generic type of device includes various single, and multi-analyte control materials." + }, + { + "input": "Concept: ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor (Molecular Function)", + "output": "something described as catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + glutaredoxin disulfide + H2O -> ribonucleoside diphosphate + glutaredoxin." + }, + { + "input": "Concept: Leukemia, T-Cell Large Granular Lymphocytic (Mature T-Cell and NK-Cell Neoplasm)", + "output": "Mature (peripheral) T-cell neoplasm described as a T-cell peripheral neoplasm characterized by a persistent (>6 months) increase in the number of peripheral blood large granular lymphocytes, without a clearly identified cause." + }, + { + "input": "Concept: Apocynum androsaemifolium / milk weed / western wall (Plant)", + "output": "Western herbs and natural substances letter A described as milk weed, Western wall." + }, + { + "input": "Concept: integral to muscle cell projection membrane (Cell Component)", + "output": "integral component of plasma membrane described as the component of the muscle cell projection membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." + }, + { + "input": "Concept: synaptic vesicle budding from pre-synaptic membrane (Cell Function)", + "output": "synaptic vesicle budding described as evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle." + }, + { + "input": "Concept: Pitch Discrimination (Mental Process)", + "output": "Pitch Perception described as the ability to differentiate sound frequency or pitch." + }, + { + "input": "Concept: regulation of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity (regulation of phosphatase activity)", + "output": "regulation of phosphatase activity described as any process that modulates the frequency, rate or extent of phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity." + }, + { + "input": "Concept: negative regulation of IL-15 production (Organism Function)", + "output": "negative regulation of cytokine production described as any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-15 production." + }, + { + "input": "Concept: Open biopsy of kidney (Nephrectomy)", + "output": "Open incision or drainage of kidney or renal pelvis described as removal of tissue from the kidney, for microscopic examination, performed during an open surgical procedure." + }, + { + "input": "Concept: PODCI Adolescent Parent-Reported Version - Competitive Sports Limited by: Season (Intellectual Product)", + "output": "PODCI Adolescent Parent-Reported Version Questionnaire Question described as pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported Version (PODCI Adolescent Parent-Reported Version) If you answered \"no\" to Question 52 above, was your child's activity limited by: Activity not in season?" + }, + { + "input": "Concept: ADL03-Talk About TV Content Within a Day (Intellectual Product)", + "output": "Intellectual Product described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, MCI Version - Did {S} talk about the content of a program within a day (24 hours) after watching it?" + }, + { + "input": "Concept: family natural planning (Therapeutic or Preventive Procedure)", + "output": "Contraception care described as a class of natural contraceptive methods in which SEXUAL ABSTINENCE is practiced a few days before and after the estimated day of ovulation, during the fertile phase. Methods for determining the fertile period or OVULATION DETECTION are based on various physiological indicators, such as circulating hormones, changes in cervical mucus (CERVIX MUCUS), and the basal body temperature." + }, + { + "input": "Concept: BAG, DRAINAGE, WITH ADHESIVE, OSTOMY (Medical Device)", + "output": "something described as an ostomy pouch and accessories is a device that consists of a bag that is attached to the patient's skin by an adhesive material and that is intended for use as a receptacle for collection of fecal material or urine following an ileostomy, colostomy, or ureterostomy (a surgically created opening of the small intestine, large intestine, or the ureter on the surface of the body). This generic type of device and its accessories includes the ostomy pouch, ostomy adhesive, the disposable colostomy appliance, ostomy collector, colostomy pouch, urinary ileostomy bag, urine collecting ureterostomy bag, ostomy drainage bag with adhesive, stomal bag, ostomy protector, and the ostomy size selector, but excludes ostomy pouches which incorporate arsenic-containing compounds." + }, + { + "input": "Concept: Occasional Macrophages Present (Finding)", + "output": "Chronic Inflammatory Infiltrate described as a morphologic finding indicating the presence of occasional macrophages in a tissue sample." + }, + { + "input": "Concept: RNA transport from cytoplasm to nucleus (Nuclear Import)", + "output": "RNA Transport described as the import of RNA from the cytoplasm to the nucleus." + }, + { + "input": "Concept: Exemestane-Lapatinib-Trastuzumab (Therapeutic or Preventive Procedure)", + "output": "Therapeutic or Preventive Procedure described as a chemotherapy regimen consisting of exemestane, lapatinib, and trastuzumab that may be used in the treatment of premenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2 (HER2; HER-2; ERBB2)-positive recurrent or metastatic breast cancer." + }, + { + "input": "Concept: obatoclax (Organic Chemical)", + "output": "Pharmacologic Substance described as a substance being studied in the treatment of several types of cancer. Obatoclax blocks the actions of certain proteins that cells need to live and it may kill cancer cells. It is a type of apoptosis inducer, a BCL2 protein antagonist, and a BH3 mimetic." + }, + { + "input": "Concept: CNC (SLC8A1 gene)", + "output": "something described as human SLC8A1 wild-type allele is located in the vicinity of 2p22.1 and is approximately 514 kb in length. This allele, which encodes sodium/calcium exchanger 1 protein, plays a role in calcium ion transport." + }, + { + "input": "Concept: C-SSRS Baseline/Screening Version - Non-Specific Active Suicidal Thoughts (C-SSRS Baseline/Screening Version Questionnaire Question)", + "output": "something described as columbia-Suicidality Severity Rating Scale Baseline/Screening Version (C-SSRS Baseline/Screening Version) Have you actually had any thoughts of killing yourself? (Past X Months)." + }, + { + "input": "Concept: Staphylococcal Enterotoxin C (Enterotoxins)", + "output": "Immunologic Factor described as the biotoxin Staphylococcal enterotoxin C." + }, + { + "input": "Concept: SAMHD1 Deoxynucleoside Triphosphate Triphosphohydrolase (Acid Anhydride Hydrolases)", + "output": "Ribonucleases described as SAM domain and HD domain-containing protein 1 (626 aa, ~72 kDa) is encoded by the human SAMHD1 gene. This protein is involved in the regulation of the viral defense response." + }, + { + "input": "Concept: germ-line sex determination (Sex determination)", + "output": "Organ or Tissue Function described as the determination of sex and sexual phenotype in an organism's germ line." + }, + { + "input": "Concept: She Chinese (Population Group)", + "output": "something described as a Chinese person from the She ethnic group." + }, + { + "input": "Concept: Abnormal posterior circulating artery morphology (Anatomical Abnormality)", + "output": "Anatomical Abnormality described as any structural anomaly of the posterior circulating artery (PCOM). []" + }, + { + "input": "Concept: Dorsalis, Nucleus Raphe (Nucleus of midbrain tegmentum)", + "output": "something described as the dorsal region of the raphe nucleus which is a source of the SEROTONERGIC NEURONS innervating the TELENCEPHALON; DIENCEPHALON; MESENCEPHALON; and RHOMBENCEPHALON." + }, + { + "input": "Concept: Screwdriver-shaped incisors (Anatomical Abnormality)", + "output": "something described as an abnormality of morphology of the incisor tooth in which the tooth is shaped like a screwdriver blade, i.e., having a rhomboid shape." + }, + { + "input": "Concept: Recurrent Malignant Female Reproductive System Neoplasm (Neoplastic Process)", + "output": "something described as the reemergence of a malignant female reproductive system neoplasm after a period of remission." + }, + { + "input": "Concept: Matched Non-Related Donor (Population Group)", + "output": "something described as a donor who is not related to the transplant recipient, but who is a human leukocyte antigen (HLA) tissue type match." + }, + { + "input": "Concept: SYSTEM, HEMODIALYSIS, ACCESS RECIRCULATION MONITORING (Medical Device)", + "output": "Medical Device described as a hemodialysis system and accessories is a device that is used as an artificial kidney system for the treatment of patients with renal failure or toxemic conditions and that consists of an extracorporeal blood system, a conventional dialyzer, a dialysate delivery system, and accessories. Blood from a patient flows through the tubing of the extracorporeal blood system and accessories to the blood compartment of the dialyzer, then returns through further tubing of the extracorporeal blood system to the patient. The dialyzer has two compartments that are separated by a semipermeable membrane. While the blood is in the blood compartment, undesirable substances in the blood pass through the semipermeable membrane into the dialysate in the dialysate compartment. The dialysate delivery system controls and monitors the dialysate circulating through the dialysate compartment of the dialyzer. (1) The extracorporeal blood system and accessories consists of tubing, pumps, pressure monitors, air foam or bubble detectors, and alarms to keep blood moving safely from the blood access device and accessories for hemodialysis (Sec. 876.5540) to the blood compartment of the dialyzer and back to the patient. (2) The conventional dialyzer allows a transfer of water and solutes between the blood and the dialysate through the semipermeable membrane. The semipermeable membrane of the conventional dialyzer has a sufficiently low permeability to water that an ultrafiltration controller is not required to prevent excessive loss of water from the patient's blood. This conventional dialyzer does not include hemodialyzers with the disposable inserts (Kiil type) (Sec. 876.5830) or dialyzers of high permeability (Sec. 876.5860). (3) The dialysate delivery system consists of mechanisms that monitor and control the temperature, conductivity, flow rate, and pressure of the dialysate and circulates dialysate through the dialysate compartment of the dialyzer. The dialysate delivery system includes the dialysate concentrate for hemodialysis (liquid or powder) and alarms to indicate abnormal dialysate conditions. This dialysate delivery system does not include the sorbent regenerated dialysate delivery system for hemodialysis (Sec. 876.5600), the dialysate delivery system of the peritoneal dialysis system and accessories (Sec. 876.5630), or the controlled dialysate delivery system of the high permeability hemodialysis system (Sec. 876.5860). (4) Remote accessories to the hemodialysis system include the unpowered dialysis chair without a scale, the powered dialysis chair without a scale, the dialyzer holder set, dialysis tie gun and ties, and hemodialysis start/stop tray." + }, + { + "input": "Concept: Virility (Social Behavior)", + "output": "Sex Behavior described as male-associated sex-specific social roles and behaviors unrelated to biologic function." + }, + { + "input": "Concept: Mixed Germ Cell Tumor of the Central Nervous System (Primary malignant neoplasm of central nervous system)", + "output": "Malignant Mixed Tumor described as a malignant germ cell tumor of the central nervous system characterized by the presence of at least two types of germ cell neoplasia." + }, + { + "input": "Concept: Osteopathic manipulation, NOS (Osteopathic procedures)", + "output": "Practice specialties described as the therapeutic application of manually guided forces by an osteopathic physician (U.S. usage) to improve physiologic function and/or support homeostasis that has been altered by somatic dysfunction." + }, + { + "input": "Concept: Reduced Glutathione-L-Cysteine-Anthocyanins Gel (Antioxidants)", + "output": "Pharmacologic Substance described as a gel formulation containing reduced glutathione, L-cysteine, and anthocyanins with potential antioxifdant, immunostimulating, and chemoprotective activities. Reduced glutathione is the primary cellular antioxidant and plays important roles in the antioxidation of reactive oxygen species and free radicals and, as a thiol-containing co-enzyme, in the detoxification of xenobiotic compounds. In addition, glutathione affects DNA synthesis and repair and exerts immunostimulating activity by increasing the production of interleukin-2 (IL-2), promoting antigen presentation, and stimulating T-suppressor/cytotoxic (CD8 cells) cells. The flavonoid anthocyanins, derived from various blue and purple flowering plants, are potent scavengers of reactive oxygen species. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61323\" active clinical trials using this agent." + }, + { + "input": "Concept: Grade 3 Sinus Disorder, CTCAE (Sinus Disorder, CTCAE)", + "output": "Finding described as stenosis with significant nasal obstruction; limiting self care ADL" + }, + { + "input": "Concept: Fibrous Cavernitides (Penile Diseases)", + "output": "Superficial fibromatosis described as a condition characterized by hardening of the PENIS due to the formation of fibrous plaques on the dorsolateral aspect of the PENIS, usually involving the membrane (tunica albuginea) surrounding the erectile tissue (corpus cavernosum penis). This may eventually cause a painful deformity of the shaft or constriction of the urethra, or both." + }, + { + "input": "Concept: 6-Deoxygalactose (Organic Chemical)", + "output": "Monosaccharides described as methylpentose structurally derived from galactose; the L isomer occurs naturally in various oligosaccharides and polysaccharides and fucosides and in the carbohydrate portion of some mucopolysaccharides and glycoproteins, including the A, B, and O blood group antigens." + }, + { + "input": "Concept: Siloxanes (Polymers)", + "output": "Polymers described as silicon polymers that contain alternate silicon and oxygen atoms in linear or cyclic molecular structures." + }, + { + "input": "Concept: Hyperglycemic-glycogenolytic factor product (Allergen class)", + "output": "Antidiabetics described as pancreatic hormone secreted by the alpha cells of the pancreatic islets; a 29-amino acid straight chain polypeptide that plays an important role in regulation of blood glucose concentration, ketone metabolism, and several other biochemical and physiological processes." + }, + { + "input": "Concept: eidetic imagery (Mental Process)", + "output": "Mental Process described as a visual image which is recalled in accurate detail. It is a sort of projection of an image on a mental screen." + }, + { + "input": "Concept: UDP-N-acetylglucosamine:serine-protein N-acetylglucosamine-1-phosphotransferase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the transfer of N-acetylglucosamine-1-phosphate to a serine residue in a protein." + }, + { + "input": "Concept: CDISC ADAS-Cog - Word Recall: Word 2 (Intellectual Product)", + "output": "ADAS-Cog CDISC Version Questionnaire Question described as alzheimer's Disease Assessment Scale-Cognitive CDISC Version (ADAS-Cog CDISC Version) Word recall task word 2 for trial 1, 2, 3." + }, + { + "input": "Concept: rifamycin (Nitrogen and nitrogen compound)", + "output": "antibiotics, intestinal described as a natural antibiotic produced by Streptomyces mediterranei, Rifamycin (Ansamycin Family) is a commonly used antimycobacterial drug that inhibits prokaryotic DNA-dependent RNA synthesis and protein synthesis; it blocks RNA-polymerase transcription initiation. Rifamycin has an activity spectrum against Gram-positive and Gram-negative bacteria, but is mainly used against Mycobacterium sp. (especially M. tuberculosis) in association with other agents to overcome resistance." + }, + { + "input": "Concept: oligosaccharide-diphosphodolichol phosphodolichohydrolase activity (pyrophosphatase activity)", + "output": "something described as catalysis of the reaction: H2O + oligosaccharide-diphosphodolichol = dolichol-phosphate + oligosaccharide phosphate." + }, + { + "input": "Concept: Refsum-Thiebaut disease (Hereditary degenerative disease of central nervous system)", + "output": "Disorder of skin AND/OR subcutaneous tissue of head described as autosomal recessive disorder of lipid metabolism in which deficiency of phytanic acid alpha-hydroxylase results in accumulation of phytanic acid; manifested chiefly by chronic polyneuritis, retinitis pigmentosa, cerebellar ataxia and elevation of protein in cerebrospinal fluid." + }, + { + "input": "Concept: MNSI1-Left Foot Other Abnormal Specify (Intellectual Product)", + "output": "something described as michigan Neuropathy Screening Instrument (MNSI) Physical assessment; appearance of left foot - other, specify." + }, + { + "input": "Concept: regulation of CCL6 secretion (regulation of chemokine secretion)", + "output": "regulation of chemokine secretion described as any process that modulates the rate, frequency or extent of the regulated release of chemokine (C-C motif) ligand 6 (CCL6) from a cell." + }, + { + "input": "Concept: cobalt-precorrin 7 C15-methyltransferase activity (Molecular Function)", + "output": "methyltransferase activity described as catalysis of the reaction: cobalt-precorrin 7 + S-adenosyl-L-methionine = cobalt-precorrin 8 + S-adenosyl-L-homocysteine + CO2." + }, + { + "input": "Concept: BEGUEZ CESAR DISEASE (Hereditary disorder of immune system)", + "output": "albinism with hematologic abnormalities described as form of phagocyte bactericidal dysfunction characterized by unusual oculocutaneous albinism, high incidence of lymphoreticular neoplasms, and recurrent pyogenic infections; in many cell types, abnormal lysosomes are present leading to defective pigment distribution and abnormal neutrophil functions; transmitted by autosomal recessive inheritance and a similar disorder occurs in the beige mouse, the Aleutian mink, and albino Hereford cattle." + }, + { + "input": "Concept: Antigen-specific T cell proliferation defect (Finding)", + "output": "Impaired antigen-specific response described as impaired proliferation and expansion of a T cell population following activation by an antigenic stimulus. []" + }, + { + "input": "Concept: Injury, Trochlear Nerve (Fourth cranial nerve finding)", + "output": "Sensory organ injury described as traumatic injuries to the TROCHLEAR NERVE." + }, + { + "input": "Concept: larval foraging behaviour (larval behavior)", + "output": "Individual Behavior described as the movement of a larva through a feeding substrate whilst feeding on food." + }, + { + "input": "Concept: IDS-SR - Interest in Sex (Intellectual Product)", + "output": "IDS-SR Questionnaire Question described as inventory of Depressive Symptomatology - Self-Report - Please circle the one response to each item that best describes you for the past seven days: Interest in sex." + }, + { + "input": "Concept: Juvenile Spondyloarthritis (Disease or Syndrome)", + "output": "Spondylarthropathies described as onset of spondyloarthritis before 18 years of age, and less commonly associated with axial disease. Encompasses the juvenile idiopathic arthritis categories of enthesitis-related arthritis and psoriatic arthritis, and includes many cases of undifferentiated arthritis." + }, + { + "input": "Concept: Estradiol Congener (Gonadal Steroid Hormones)", + "output": "Gonadal Steroid Hormones described as steroidal compounds related to ESTRADIOL, the major mammalian female sex hormone. Estradiol congeners include important estradiol precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with estrogenic activities." + }, + { + "input": "Concept: ng*h/mL/mg/kg (Measurement Unit Description)", + "output": "something described as hours times nanograms per milliliter per milligram per kilogram." + }, + { + "input": "Concept: Set (Response Parameters)", + "output": "something described as cognitive state of concentration or behavioral readiness to respond. Also, deliberate or inadvertent style or tendency to respond to test items in characteristic ways (e.g., with socially desirable answers) that detract from the validity of the obtained measures." + }, + { + "input": "Concept: UREASE (Protein or Enzyme Type Measurement)", + "output": "something described as the determination of the urease present in a sample." + }, + { + "input": "Concept: upregulation of glycine secretion, neurotransmission (positive regulation of neurotransmitter secretion)", + "output": "Cell Function described as any process that activates or increases the frequency, rate or extent of glycine secretion, neurotransmission." + }, + { + "input": "Concept: RECEPT BETA THYROID HORMONE (Thyroid Hormone Receptor)", + "output": "Receptor described as thyroid hormone receptor beta (461 aa, ~53 kDa) is encoded by the human THRB gene. This protein plays a role in transcriptional regulation." + }, + { + "input": "Concept: WDR5 (Gene or Genome)", + "output": "Transcription Regulation Gene described as this gene plays a role in the regulation of histone modification." + }, + { + "input": "Concept: JAK2 Activating Gene Mutation (JAK2 Gene Mutation)", + "output": "Cell or Molecular Dysfunction described as a change in the nucleotide sequence of the JAK2 gene that that results in constitutive activation of both tyrosine-protein kinase JAK2 and its downstream signaling pathways." + }, + { + "input": "Concept: GINGIVAL CANCER, CARCINOMA (Oral Cavity Carcinoma)", + "output": "Oral Cavity Carcinoma described as a carcinoma of the oral cavity that arises from the upper or lower gingiva." + }, + { + "input": "Concept: Ventriculomegaly (Disorders of cerebrospinal fluid and intracranial pressure)", + "output": "Brain Diseases described as abnormal enlargement of the cerebral ventricles." + }, + { + "input": "Concept: Ocular Adnexal Lymphoma cM1b TNM Finding v8 (Ocular Adnexal Lymphoma Clinical Distant Metastasis TNM Finding v8)", + "output": "Finding described as ocular adnexal lymphoma with lymphomatous involvement of the bone marrow." + }, + { + "input": "Concept: Transient Receptor Potential Cation Channel Subfamily V Member 6 (Amino Acid, Peptide, or Protein)", + "output": "something described as a protein found in cell membranes that moves calcium into cells. Levels of transient receptor potential cation channel, subfamily V, member 6 are lower than normal in patients who don't have enough vitamin D. High levels of the protein may be found in breast cancer tissue. It is a type of calcium channel protein." + }, + { + "input": "Concept: Procedure Kit/Trays, Biopsy, Soft Tissue (Medical Device)", + "output": "Procedure Kit/Trays, Biopsy described as prepackaged collections of the devices and supplies (either custom or standard) needed for performing a soft tissue biopsy procedure. Items in these kits usually include Luer lock syringes, needles, anesthetics, scalpel, specimen tubes with caps, microscope slides, and a ruler; kits may also include gauze pads, towels, a fenestrated drape, and adhesive bandages. The kits are frequently supplied in supporting trays (i.e., procedure trays) consisting of a flat-bottomed receptacle with a border around the periphery supporting all the instruments and supplies needed for the procedure; the trays are usually covered or wrapped. Soft tissue biopsy procedure kits and trays are intended for use during the removal of a small sample of soft tissue (e.g., skin, fat, muscle, tendon) for microscopic (in-vitro) laboratory examination." + }, + { + "input": "Concept: Graft versus Host Disease Lung Symptom Score (Intellectual Product)", + "output": "Intellectual Product described as a score for graft versus host disease based on the severity of lung symptoms." + }, + { + "input": "Concept: parkin (Gene or Genome)", + "output": "Gene Mutation described as this gene may play a role in the mediation of proteasomal targeting." + }, + { + "input": "Concept: regulation of hair follicle development (regulation of hair cycle)", + "output": "Biologic Function described as any process that modulates the frequency, rate or extent of hair follicle development." + }, + { + "input": "Concept: CDC73 Met1Val (CDC73 Protein Variant)", + "output": "Cell or Molecular Dysfunction described as a change in the amino acid residue at position 1 in the parafibromin protein where methionine has been replaced by valine." + }, + { + "input": "Concept: Organic and Synthetic Chemistry Shared Resource (Clinical or Research Facility)", + "output": "Clinical or Research Facility described as organic and Synthetic Chemistry Shared Resource provides researchers in Cancer Center with custom synthesis of chemicals pertaining to cancer biology in terms of causation, prevention, and intervention, that are not commercially available or are prohibitively expensive, and expertise in biocatalysis, organometallics, chiral synthesis, biotransformations, enzyme inhibitors. Resource also provides consultations regarding problems in chemical synthesis and modification, assistance in the spectroscopic characterization of unknown compounds, access to combinatorial synthesis, and support in drug development efforts." + }, + { + "input": "Concept: Myb complex (Cell Component)", + "output": "something described as a multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression." + }, + { + "input": "Concept: USTILAGO CYNODONTIS (Fungus)", + "output": "something described as a species of smut fungi in the phylum Basidiomycota. This species causes smut in various grasses." + }, + { + "input": "Concept: Mycosis Fungoides and S\u00e9zary Syndrome N0 TNM Finding v7 (Finding)", + "output": "Mycosis Fungoides and Sezary Syndrome Lymph Nodes TNM Finding v7 described as no clinically abnormal peripheral lymph nodes; biopsy not required. Note: for node, abnormal peripheral lymph node(s) indicates any palpable peripheral node that on physical examination is firm, irregular, clustered, fixed or 1.5 cm or larger in diameter. Node groups examined on physical examination include cervical, supraclavicular, epitrochlear, axillary, and inguinal. Central nodes, which are not generally amenable to pathologic assessment, are not currently considered in the nodal classification unless used to establish N3 histopathology." + }, + { + "input": "Concept: mucic acid metabolic process (Molecular Function)", + "output": "something described as the chemical reactions and pathways involving galactarate, an anion of galactaric acid, the meso-aldaric acid derived from both D- and L-galactose." + }, + { + "input": "Concept: Hilar Cholangiocarcinoma TNM Finding v8 (Hepatobiliary System Cancer TNM Finding v8)", + "output": "something described as a finding about one or more characteristics of perihilar bile duct cancer, following the rules of the TNM AJCC v8 classification system. This staging system applies to perihilar cholangiocarcinomas. Well-differentiated neuroendocrine tumors and sarcomas are not staged using this staging system." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Serology, Bacteria, Salmonella Species (IVD Test Reagent/Kits, Serology, Bacteria)", + "output": "IVD Test Reagent/Kits, Serology, Bacteria described as serology reagents intended to detect antibody titers or antigens of species of Salmonella, a genus of motile bacteria with peritrichous flagella of the family Enterobacteriaceae. Salmonella bacteria that are pathologic to humans include S. typhi, the cause of typhoid fever, and S. choleraesuis, an etiologic agent of paratyphoid, gastroenteritis, and septicemia." + }, + { + "input": "Concept: Mind/body Exercise (Therapeutic or Preventive Procedure)", + "output": "CAM Exercise Therapy described as a form of exercise that combines body movement with mental focus and controlled breathing to improve strength, balance, flexibility, and overall health. Examples of mind/body exercises are yoga, tai chi, and qigong." + }, + { + "input": "Concept: direct antiglobulin test (Laboratory Procedure)", + "output": "Blood bank procedure described as a measurement of the antibody or complement-coated erythrocytes in a blood specimen in vivo." + }, + { + "input": "Concept: Laryngostroboscopes (Device associated with amplifiers)", + "output": "Ear, nose and throat device described as a laryngostroboscope is a device that is intended to allow observation of glottic action during phonation. The device operates by focusing a stroboscopic light through a lens for direct or mirror reflected viewing of glottic action. The light and microphone that amplifies acoustic signals from the glottic area may or may not contact the patient." + }, + { + "input": "Concept: IDS-SR - Constipation or Diarrhea (IDS-SR Questionnaire Question)", + "output": "something described as inventory of Depressive Symptomatology - Self-Report - Please circle the one response to each item that best describes you for the past seven days: Constipation/diarrhea." + }, + { + "input": "Concept: IVD Panels, Human Genetics, Metal Accumulation, Copper/Iron, Mutation (IVD Panels, Human Genetics, Metabolic Disorder, Metal Accumulation)", + "output": "IVD Panels, Human Genetics, Metabolic Disorder, Metal Accumulation described as molecular assay reagents intended to identify mutations in genes associated with errors in either copper or iron metabolism that lead to accumulation of these metals in tissues. Genetic variants at multiple loci have been associated with copper/iron accumulation. These reagents are intended to detect mutations in multiple copper/iron accumulation-associated loci simultaneously." + }, + { + "input": "Concept: breast tumor (Mammary Neoplasms)", + "output": "Physical & Psychosomatic Disorders described as new abnormal mammary tissue that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease." + }, + { + "input": "Concept: Ligament of left vena cava (Transformed vein)", + "output": "Body Part, Organ, or Organ Component described as transformed vein, each instance of which is a remnant of some embryonic left superior vena cava or duct of Cuvier, extending from some left superior intercostal vein to the oblique vein of some left atrium; it is enclosed by the fold of some left superior vena cava." + }, + { + "input": "Concept: Hereditary nonspherocytic haemolytic anaemia (Anemia due to enzyme deficiency)", + "output": "Anemia, Hemolytic described as group of congenital hemolytic anemias in which there is no abnormal hemoglobin or spherocytosis and in which there is a defect of glycolysis in the erythrocyte; in some cases, pyruvate kinase deficiency has been demonstrated; in other cases, glucose-6-phosphate dehydrogenase deficiency has been demonstrated." + }, + { + "input": "Concept: Mild immune presence (Immune Presence)", + "output": "Finding described as approximately 10-20 percent of the tissue surface area is occupied by immune cell infiltration." + }, + { + "input": "Concept: SGRQ0142 (St George's Respiratory Questionnaire Past 3 Months Version Questionnaire Question)", + "output": "St George's Respiratory Questionnaire Past 3 Months Version Questionnaire Question described as st. George's Respiratory Questionnaire Past 3 Months Version (SGRQ Past 3 Months Version) These are questions about how your activities might be affected by your respiratory problems: If I hurry or walk fast, I have to stop or slow down." + }, + { + "input": "Concept: Clinical Laboratory Automation Systems (Medical Device)", + "output": "Automation Systems described as automation systems used in clinical laboratories to prepare, analyze, and evaluate samples. These systems typically consist of several modules for specimen handling and processing that work as a network connected by a transportation system and under software control; they can perform tasks in sequence with minimal operator intervention. The systems usually include modules for sample preparation (preanalytic modules), analysis of samples (e.g., hematology, clinical chemistry, immunoassay), and recompilation and evaluation of results (postanalytic modules). Each module typically includes several units (e.g., decappers, sorters, centrifuges, analyzers, refrigerators) that may be either standard clinical laboratory equipment or, more frequently, specially designed units for the automation system. Laboratory automation systems are intended to improve the safety and/or efficiency of laboratory procedures; they are frequently configured according to particular laboratory requirements. Most of these systems can interact with laboratory and/or hospital information systems." + }, + { + "input": "Concept: immunoglobulin injections (Response to immunization AND/OR skin test)", + "output": "Administration of blood product described as the conference of active humoral immunity from one individual to another via the transfer of formed antibodies." + }, + { + "input": "Concept: Disorder, Child Mental (Pervasive developmental disorders NEC)", + "output": "Developmental disorders cognitive described as conditions characterized by impaired central nervous system function occurring in childhood." + }, + { + "input": "Concept: FAC061-I Am Able to Concentrate (Intellectual Product)", + "output": "Intellectual Product described as functional Assessment of Cancer Therapy-Bone Marrow Transplant Version 4 (FACT-BMT Version 4) I am able to concentrate." + }, + { + "input": "Concept: L-\u03b1-pyrrolidinecarboxylic acid (Aromatic Amino Acids)", + "output": "Aromatic Amino Acids described as a non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons." + }, + { + "input": "Concept: positive regulation of chondrocyte cell proliferation (Stimulation of Cell Proliferation)", + "output": "Stimulation of Cell Proliferation described as any process that increases the frequency, rate or extent of the multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage." + }, + { + "input": "Concept: Mesangial Cells, Renal (Kidney Glomerulus)", + "output": "Entire cell described as smooth muscle-like cells adhering to the wall of the small blood vessels of the KIDNEY at the glomerulus and along the vascular pole of the glomerulus in the JUXTAGLOMERULAR APPARATUS. They are myofibroblasts with contractile and phagocytic properties. These cells and their MESANGIAL EXTRACELLULAR MATRIX constitute the GLOMERULAR MESANGIUM." + }, + { + "input": "Concept: HAMD1-Suicide (Intellectual Product)", + "output": "HAMD-17 Questionnaire Question described as hamilton Depression Rating Scale 17 Item - Suicide." + }, + { + "input": "Concept: Virus Infection, SFTS (Phleboviral infections)", + "output": "Bunyaviridae Infections described as severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging infectious disease." + }, + { + "input": "Concept: regulation of cytoplasmic mRNA processing body assembly (regulation of organelle assembly)", + "output": "something described as any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." + }, + { + "input": "Concept: cellular response to mannitol stimulus (cellular response to carbohydrate stimulus)", + "output": "cellular response to carbohydrate stimulus described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannitol stimulus." + }, + { + "input": "Concept: Fallot's type pulmonary atresia (Tetralogy of Fallot)", + "output": "Congenital Abnormality described as an extreme form of tetralogy of Fallot characterized by absence of flow from the right ventricle to the pulmonary arteries." + }, + { + "input": "Concept: sensory system (Body System)", + "output": "body system or organ described as one of three basic components of the cerebrospinal trunk of the central nervous system segmented on the basis of embryogenesis, connectivity and function ( Swanson-2004 ).The other components are the behavioral state system and the subcortical motor system. \\r\\nThe subcortical sensory systems include the set of structures of the cerebrospinal trunk that are primarily involved in processing inputs from the external environment and from internal organs ( Swanson-2003 ). Specifically they include structures of the subcortical visual system, the somatosensory system, the subcortical auditory system, the gustatory system, the viscerosensory system, the humerosensory system and related nuclei of the thalamus." + }, + { + "input": "Concept: Safety Syringe Caps (Device Labeled for Single Use)", + "output": "Syringes described as devices designed to cover syringe tips in order to prevent syringe content leakage and maintain sterility until the syringe is used. They are typically constructed of plastic or polypropylene and may come in multiple colors for color coding medications. These caps may be designed to fit a specific type of syringe tip (e.g., luer slip, luer lock)." + }, + { + "input": "Concept: STRUCTURALLY DIVERSE SUBSTANCE (Substance)", + "output": "something described as a type of polydisperse substance isolated from a single source that is a complex mixture which cannot be described as a limited set of single substance." + }, + { + "input": "Concept: activation of emodin anabolism (positive regulation of cellular biosynthetic process)", + "output": "Molecular Function described as any process that activates or increases the frequency, rate or extent of emodin biosynthetic process." + }, + { + "input": "Concept: Syringes, Plunger, Luer Slip, Eccentric Tip (Syringes, Plunger, Luer Slip)", + "output": "Syringes, Plunger, Luer Slip described as plunger syringes designed with a nonconcentric (i.e., eccentric) Luer-slip male tapering fitting (tip). These syringes provide a connection with other medical devices, typically a needle, that is almost flush with the side of the barrel." + }, + { + "input": "Concept: Number of Cusps (Number of occurrences)", + "output": "Number of occurrences described as a quantitative determination of the number of cusps composing a given cardiac valve." + }, + { + "input": "Concept: TOMUZOTUXIMAB (Immunologic Factor)", + "output": "Immunologic Factor described as a glycoengineered second-generation antibody of cetuximab with potential antineoplastic activities. Upon intravenous administration, tomuzotuximab selectively binds to the extracellular domain of the epidermal growth factor receptor (EGFR), thereby preventing the activation and subsequent dimerization of the receptor. This may prevent EGFR-mediated signaling and inhibit EGFR-dependent tumor cell proliferation. Further, tomuzotuximab has a fully human glycosylation pattern and is glyco-optimized at its Fc domain to promote antibody-dependent cell-mediated cytotoxicity (ADCC). EGFR, a member of the epidermal growth factor family of extracellular protein ligands, may be overexpressed on the cell surfaces of certain tumor types." + }, + { + "input": "Concept: Sarcomas, Langerhans Cell (Sarcoma - category)", + "output": "Primary malignant neoplasm described as rare malignant neoplasm of dendritic LANGERHANS CELLS exhibiting atypical cytology, frequent mitoses, and aggressive clinical behavior. They can be distinguished from other histiocytic and dendritic proliferations by immunohistochemical and ultrastructure studies. Cytologically benign proliferations of Langerhans cells are called LANGERHANS CELL HISTIOCYTOSIS." + }, + { + "input": "Concept: eosinophil degranulation (leukocyte degranulation)", + "output": "something described as the regulated exocytosis of secretory granules containing preformed mediators such as major basic protein, eosinophil peroxidase, and eosinophil cationic protein by an eosinophil." + }, + { + "input": "Concept: Distress About Illness or Treatment to Those Close to You (Findings-Based Question)", + "output": "Intellectual Product described as a question about whether an individual feels those close to them are distressed by their disease or treatment." + }, + { + "input": "Concept: Rickettsia da Rocha-Lima 1916 (Order Rickettsiales)", + "output": "Rickettsieae described as in the Rickettsiaceae family, a genus of gram negative, aerobic, rod shaped bacteria often surrounded by a protein microcapsular layer and slime layer; the natural cycle of its organisms generally involves a vertebrate and an invertebrate host; species of the genus are the etiological agents of human diseases, such as typhus." + }, + { + "input": "Concept: Testis Secretory Sperm-Binding Protein Li 223n (Biologically Active Substance)", + "output": "Biologically Active Substance described as testis-specific H1 histone (255 aa, ~28 kDa) is encoded by the human H1-7 gene. This protein is involved in the histone-protamine transition of sperm chromatin." + }, + { + "input": "Concept: Readiness for enhanced resilience (Finding)", + "output": "Finding described as a pattern of ability to recover from perceived adverse or changing situations, through a dynamic process of adaptation, which can be strengthened." + }, + { + "input": "Concept: Postive urine pot test (Urine xenobiotic)", + "output": "Finding described as detection of delta-9-tetrahydrocannabinol (THC) or other cannabinoid metabolites in urine. []" + }, + { + "input": "Concept: Reference Period (Period)", + "output": "something described as a time frame that is of value for its relationship to a notable event." + }, + { + "input": "Concept: Myeloablative Cytoreduction (Therapeutic or Preventive Procedure)", + "output": "something described as a conditioning regimen with high doses of chemotherapy or radiation to eliminate host hematopoietic stem cells prior to restitution via transplantation." + }, + { + "input": "Concept: Intraluminal Route of Drug Administration (RouteBySite)", + "output": "Functional Concept described as a route that begins within the channel of a tubular structure or tubular organ." + }, + { + "input": "Concept: MDA-N (NCI-60 Cell Line)", + "output": "Experimental Model of Disease described as a melanoma cell line derived from the MDA-MB-435 cell line." + }, + { + "input": "Concept: Clinical Trial Candidate (Candidate)", + "output": "Candidate described as a patient who meets the eligibility criteria for participation in a clinical trial." + }, + { + "input": "Concept: down regulation of mismatch repair (Genetic Function)", + "output": "negative regulation of DNA repair described as any process that stops, prevents, or reduces the frequency, rate or extent of mismatch repair." + }, + { + "input": "Concept: lysine 2,3-aminomutase activity (intramolecular transferase activity, transferring amino groups)", + "output": "Molecular Function described as catalysis of the reaction: L-lysine = (3S)-3,6-diaminohexanoate." + }, + { + "input": "Concept: Platinum-Sensitive Fallopian Tube Cancer (Fallopian Tube Carcinoma)", + "output": "Fallopian Tube Carcinoma described as fallopian tube carcinoma that has a documented response to platinum-based chemotherapy." + }, + { + "input": "Concept: Folate Carrier, Reduced (Folic Acid Transporters)", + "output": "something described as a ubiquitously expressed folic acid transporter that functions via an antiporter mechanism which is coupled to the transport of organic phosphates." + }, + { + "input": "Concept: oriconazole (Azole Antifungal [EPC])", + "output": "Piperazines described as a synthetic triazole agent with antimycotic properties. Formulated for both topical and systemic use, itraconazole preferentially inhibits fugal cytochrome P450 enzymes, resulting in a decrease in fungal ergosterol synthesis. Because of its low toxicity profile, this agent can be used for long-term maintenance treatment of chronic fungal infections. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1138\" active clinical trials using this agent." + }, + { + "input": "Concept: Cervical (Spatial Concept)", + "output": "something described as applies to an abnormality that is situated in the neck. []" + }, + { + "input": "Concept: Clathrin Coated Vesicles (Coated vesicle)", + "output": "Coated vesicle described as a vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." + }, + { + "input": "Concept: 4'-Deoxy-20',20'-difluoro-C'-norvincaleukoblastine (Organic Chemical)", + "output": "Pharmacologic Substance described as a bi-fluorinated derivative of the semi-synthetic vinca alkaloid vinorelbine with antitubulin, antineoplastic, and antiangiogenic activities. Vinflunine inhibits tubulin assembly without any stablization of assembled microtubules at concentrations comparable to those of other vinca alkaloids such as vincristine, vinblastine and vinorelbine; this effect on microtubule dynamics results in cell cycle arrest in mitosis and apoptosis. Compared to other vinca alkaloids, this agent binds weakly to the vinca-binding site, indicating that vinflunine may exhibit reduced neurotoxicity. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61564\" active clinical trials using this agent." + }, + { + "input": "Concept: Cachexia (Sign or Symptom)", + "output": "Emaciation described as general ill health, malnutrition, and weight loss, usually associated with chronic disease." + }, + { + "input": "Concept: Difluconazole (F [Preparations])", + "output": "Antibiotics, Antifungal described as alpha-(2,4-difluorophenyl)-alpha- (1,2,4-triazol-1-ylmethyl)-1,2, 4- triazole-1-ethanol; an antifungal with potential efficacy for patients unable to take amphotericin B or who are immunologically compromised, as in AIDS." + }, + { + "input": "Concept: Tubulina (Eukaryote)", + "output": "Order Amoebida described as a suborder of ameboid protozoa characterized by a branched or unbranched cylindrical body and the absence of bidirectional cytoplasmic flow. Nuclear division is mesomitotic." + }, + { + "input": "Concept: regulation of B-1 B lymphocyte differentiation (regulation of B cell differentiation)", + "output": "Cell Function described as any process that modulates the frequency, rate, or extent of B-1 B cell differentiation. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." + }, + { + "input": "Concept: Denturists (Healthcare Assistants)", + "output": "Dental Technicians described as a dental technician who provides dentures for patients without supervision of a dentist. Their duties include taking impressions and bite registrations for preparing and repairing dentures and fitting dentures." + }, + { + "input": "Concept: Fraternity Membership (Daily or Recreational Activity)", + "output": "Student Characteristics & Academic Environment described as belonging to a club traditionally restricted to males. Used also for fraternity organizations." + }, + { + "input": "Concept: Personality Tests (Measurement)", + "output": "Nonprojective Personality Measures described as standardized objective tests designed to facilitate the evaluation of personality." + }, + { + "input": "Concept: HAMD406 (HAM-D6 Clinician Version Clinical Classification Question)", + "output": "HAM-D6 Clinician Version Clinical Classification Question described as the Hamilton Depression Rating Scale 6 - Clinician Version - Tiredness and pains." + }, + { + "input": "Concept: MMS1-Fold in Half (MMSE Functional Test Question)", + "output": "something described as mini-Mental State Examination (MMSE) Fold it in half." + }, + { + "input": "Concept: Postnatal Stage (Maternal Life Stage)", + "output": "something described as the stage in the life of a mother after she has given birth." + }, + { + "input": "Concept: ALK Tyrosine Kinase Receptor Phe1245Leu (Cell or Molecular Dysfunction)", + "output": "something described as a change in the amino acid residue at position 1245 in the ALK tyrosine kinase receptor protein where phenylalanine has been replaced by leucine." + }, + { + "input": "Concept: Musculoskeletal Development (Organogenesis)", + "output": "Musculoskeletal Physiological Phenomena described as the morphologic and physiological changes of the MUSCLES, bones (BONE AND BONES), and CARTILAGE of the body, i.e., MUSCULOSKELETAL SYSTEM, during the prenatal and postnatal stages of development." + }, + { + "input": "Concept: Trichostrongylus orientalis (Trichostrongylus)", + "output": "Eukaryote described as a species of parasitic roundworms in the family Trichostrongylidae that is most prevalent in Asian countries." + }, + { + "input": "Concept: positive regulation of phospholipid translocation (positive regulation of phospholipid transport)", + "output": "positive regulation of phospholipid transport described as any process that increases the frequency, rate or extent of the translocation, or flipping, of phospholipid molecules from one monolayer of a membrane bilayer to the opposite monolayer." + }, + { + "input": "Concept: Non-Commercial Sources (Classification)", + "output": "Business Rules described as a category used for classifying sources of research reagents obtained through academic institutions." + }, + { + "input": "Concept: with staging (Health Care)", + "output": "Health Care described as the process of defining at what point in the natural history of a malignant disease a patient is when a diagnosis is made." + }, + { + "input": "Concept: brace (Stabilizing appliance)", + "output": "Medical Device described as orthopedic appliances used to support, align, or hold parts of the body in correct position." + }, + { + "input": "Concept: FORMULATIONS, BALANCED SALT SOLUTIONS (Indicator, Reagent, or Diagnostic Aid)", + "output": "Indicator, Reagent, or Diagnostic Aid described as a balanced salt solution or formulation is a defined mixture of salts and glucose in a simple medium. This device is included as a necessary component of most cell culture systems. This media component controls for pH, osmotic pressure, energy source, and inorganic ions." + }, + { + "input": "Concept: Fistula between oral cavity and cutaneous surface of face (Oral Fistula)", + "output": "something described as an abnormal communication between the skin and the oral cavity." + }, + { + "input": "Concept: Labor Risk (Perinatal risk)", + "output": "something described as increased chance of harm during the period supporting the bringing forth of an offspring / child" + }, + { + "input": "Concept: Sarcolacticum acidum (Homeopathic remedies letter S)", + "output": "Homeopathic remedies letter S described as sarcolactic acid." + }, + { + "input": "Concept: repressor ecdysone receptor complex (Cell Component)", + "output": "something described as a protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) plus an associated corepressor such as SMRTER, which represses transcription of target genes." + }, + { + "input": "Concept: Oligochaeta (Eukaryote)", + "output": "Annelida described as a class of annelid worms with few setae per segment. It includes the earthworms such as Lumbricus and Eisenia." + }, + { + "input": "Concept: Anastomosing vein of Labbe (Structure of cerebral vein)", + "output": "Veins described as superficial cerebral vein, each instance of which interconnects some middle cerebral vein and some superior sagittal sinus." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Home Assay, Whole Blood, Sampling (Medical Device)", + "output": "something described as reagents available as home test kits that permit the rapid collection of sample (i.e., specimen) of whole blood. These kits usually include the necessary devices and materials to obtain a whole blood sample (e.g., lancets, blood collection cards, alcohol towelettes, gauze pads, bandage); the kit usually includes a unique personal identification code and booklets with sampling instructions and information appropriate to the intended test to be performed. Whole blood sampling kits for home use permit patients to collect specimens in the privacy of their home; the samples are intended for anonymous analysis in a qualified laboratory for primary detection of microorganisms (e.g., HIV, hepatitis C virus), which are not considered possible or convenient for home assessment." + }, + { + "input": "Concept: S6PHS (Protein or Enzyme Type Measurement)", + "output": "Protein or Enzyme Type Measurement described as the determination of the amount of phosphorylated S6 protein of the 40S ribosomal subunit present in a sample." + }, + { + "input": "Concept: Zygomycosis, unspecified (Disease or Syndrome)", + "output": "Disease or Syndrome described as any infection due to a fungus of the Zygomycota phylum. The disease typically involves the rhino-facial-cranial area, lungs, gastrointestinal tract, skin, or less commonly other organ systems. The infecting fungi have a predilection for invading vessels of the arterial system, causing embolization and subsequent necrosis of surrounding tissue." + }, + { + "input": "Concept: Fadrozole (Imidazoles)", + "output": "something described as a selective aromatase inhibitor effective in the treatment of estrogen-dependent disease including breast cancer." + }, + { + "input": "Concept: Soft Tissue Sarcoma pT0 TNM Finding v7 (Finding)", + "output": "something described as soft tissue sarcoma with no evidence of primary tumor." + }, + { + "input": "Concept: ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase activity (phosphatidylinositol kinase activity)", + "output": "phosphatidylinositol kinase activity described as catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+)." + }, + { + "input": "Concept: CPS01-PT, INR (Child-Pugh Clinical Classification Question)", + "output": "Intellectual Product described as child-Pugh Classification - Prothrombin time, international normalized ratio (INR)." + }, + { + "input": "Concept: Left kidney (Kidney)", + "output": "Urinary system described as a bean-shaped retroperitoneal organ situated below the diaphragm and posterior to the spleen." + }, + { + "input": "Concept: Hepatic Flavin-Containing Monooxygenase-3 (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as dimethylaniline monooxygenase [N-oxide-forming] 3 (532 aa, ~60 kDa) is encoded by the human FMO3 gene. This protein is involved in the oxygenation primary aliphatic alkylamines and both secondary and tertiary amines" + }, + { + "input": "Concept: negative regulation of histone H3-K4 acetylation (Molecular Function)", + "output": "negative regulation of histone acetylation described as any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K4 acetylation." + }, + { + "input": "Concept: Antifungal product (Drugs and Biologicals)", + "output": "USP Medicare Model Guidelines described as a drug that kills fungus" + }, + { + "input": "Concept: In-111-Bevacizumab (Pharmacologic Substance)", + "output": "Radioimmunoconjugates described as a radioimmunoconjugate comprised of the recombinant humanized monoclonal antibody bevacizumab conjugated with the gamma-emitting radioisotope indium In 111. Indium I 111 bevacizumab binds to vascular endothelial growth factor (VEGF), allowing the detection of VEGF distribution using gamma scintigraphy." + }, + { + "input": "Concept: I have had a change in the way food tastes (Intellectual Product)", + "output": "Intellectual Product described as a question about whether an individual notices or noticed a change in the way food tastes." + }, + { + "input": "Concept: Assay, Enzyme-Linked Immunosorbent (Laboratory Procedure)", + "output": "Immunoassay method described as immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase; while either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye; many variations of the method have been developed." + }, + { + "input": "Concept: Breakthrough Pains (Pain)", + "output": "Pain described as many people with chronic cancer-related pain experience intermittent flares of pain that can occur even though a person is taking analgesic medications on a fixed schedule for pain control. These severe flares of pain are called breakthrough pain because the pain \"breaks through\" the regular pain medication." + }, + { + "input": "Concept: DefinedNotification.messageTitle (Message Title)", + "output": "Message Title described as the subject of the notification." + }, + { + "input": "Concept: Grade 2 Hyperthyroidism (Hyperthyroidism, CTCAE)", + "output": "Finding described as symptomatic; thyroid suppression therapy indicated; limiting instrumental ADL" + }, + { + "input": "Concept: Gastro-enteritis virus of swine (Genus: Coronavirus)", + "output": "something described as a species of CORONAVIRUS causing a fatal disease to pigs under 3 weeks old." + }, + { + "input": "Concept: CDRS103 (CDRS-R Clinical Classification Question)", + "output": "something described as children's Depression Rating Scale, Revised - Social withdrawal." + }, + { + "input": "Concept: positive regulation of interleukin-9 biosynthesis (positive regulation of cytokine biosynthetic process)", + "output": "regulation of interleukin-9 biosynthetic process described as any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-9." + }, + { + "input": "Concept: 11-cis-retinal binding (retinal binding)", + "output": "Molecular Function described as interacting selectively and non-covalently with 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A." + }, + { + "input": "Concept: Mutation of the Nucleophosmin Gene (Cell or Molecular Dysfunction)", + "output": "something described as mutation of the nucleophosmin gene. It is seen in acute myeloid leukemias usually associated with a normal karyotype." + }, + { + "input": "Concept: type 4 melanocortin receptor binding (Molecular Function)", + "output": "melanocortin receptor binding described as interacting selectively and non-covalently with a type 4 melanocortin receptor." + }, + { + "input": "Concept: Radiation-Related Leukemia (Radiation injury)", + "output": "Radiation injury described as leukemia that is caused by radiation." + }, + { + "input": "Concept: Myocardium of inflow part of right atrium (Wall proper of inflow part of right atrium)", + "output": "Wall proper of inflow part of right atrium described as myocardium of region of atrium which is continuous with the tunica media of superior and inferior vena cavae." + }, + { + "input": "Concept: Radiologist, NOS (Medical Occupation)", + "output": "Professional or Occupational Group described as a physician who specializes in the diagnostic and/or therapeutic uses of radiation." + }, + { + "input": "Concept: GUIDE, SURGICAL, INSTRUMENT (Device Labeled for Single Use)", + "output": "something described as a manual surgical instrument for general use is a nonpowered, hand-held, or hand-manipulated device, either reusable or disposable, intended to be used in various general surgical procedures. The device includes the applicator, clip applier, biopsy brush, manual dermabrasion brush, scrub brush, cannula, ligature carrier, chisel, clamp, contractor, curette, cutter, dissector, elevator, skin graft expander, file, forceps, gouge, instrument guide, needle guide, hammer, hemostat, amputation hook, ligature passing and knot-tying instrument, knife, blood lancet, mallet, disposable or reusable aspiration and injection needle, disposable or reusable suturing needle, osteotome, pliers, rasp, retainer, retractor, saw, scalpel blade, scalpel handle, one-piece scalpel, snare, spatula, stapler, disposable or reusable stripper, stylet, suturing apparatus for the stomach and intestine, measuring tape, and calipers. A surgical instrument that has specialized uses in a specific medical specialty is classified in separate regulations in Parts 868 through 892." + }, + { + "input": "Concept: c.460G>A (Finding)", + "output": "Finding described as TPMT *3B allele" + }, + { + "input": "Concept: Neisseria weichselbaumii (Neisseriaceae)", + "output": "Neisseria species described as gram-negative, aerobic bacteria; a commensal and pathogen only of humans, and can be carried asymptomatically in the nasopharynx; when found in cerebrospinal fluid it is the causative agent of cerebrospinal meningitis; also found in venereal discharges and blood; there are at least 13 serogroups based on antigenic differences in the capsular polysaccharides; the ones causing most meningitis infections being A, B, C, Y, and W-135; each serogroup can be further classifed by serotype, serosubtype, and immunotype." + }, + { + "input": "Concept: Beta Streptococcus Group F (Streptococcus)", + "output": "something described as a non-taxonomic grouping of beta-hemolytic species within the Streptococcus genus that are assigned to the F group." + }, + { + "input": "Concept: immune response in Peyer's patch (immune response in gut-associated lymphoid tissue)", + "output": "Organ or Tissue Function described as immune response taking place in the Peyer's patch, nodular lymphoid structures on the serosal surface of the small intestine." + }, + { + "input": "Concept: synaptic vesicle processing via endosome (endosomal transport)", + "output": "endosomal transport described as the process in which synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles." + }, + { + "input": "Concept: arteriograms (Medical Image)", + "output": "something described as an x-ray of arteries. The person receives an injection of a dye that outlines the vessels on the x-ray." + }, + { + "input": "Concept: Amsler chart (Charts)", + "output": "Charts described as an Amsler grid is a device that is a series of charts with grids of different sizes that are held at 30 centimeters distance from the patient and intended to rapidly detect central and paracentral irregularities in the visual field." + }, + { + "input": "Concept: WHODAS 2.0 36-item Version Self-administered - Getting Out of Your Home (WHODAS 2.0 36-item Version Self-administered Questionnaire Question)", + "output": "Intellectual Product described as world Health Organization Disability Assessment Schedule 2.0 - 36-Item Self - In the past 30 days, how much difficulty did you have in: Getting out of your home?" + }, + { + "input": "Concept: juvenile animal (immature animal)", + "output": "something described as animal between infancy and adulthood." + }, + { + "input": "Concept: RNA polymerase II C-terminal domain binding (Molecular Function)", + "output": "something described as interacting selectively and non-covalently with the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. The CTD is comprised of repeats of a heptapeptide with the consensus sequence YSPTSPS. The number of repeats varies with the species and a minimum number of repeats is required for RNAP II function." + }, + { + "input": "Concept: IPAQ Short Last 7 Days Self-administered Format Version - Time Sitting Don't Know/Not Sure (IPAQ Short Last 7 Days Self-administered Format Version Questionnaire Question)", + "output": "Intellectual Product described as international Physical Activity Questionnaire (August 2002) - Short Last 7 Days Self-Administered Format - During the last 7 days, how much time did you spend sitting on a weekday?: Don't know/Not sure." + }, + { + "input": "Concept: HEPA Filters (environmental control measures)", + "output": "Medical Device described as particulate air filters designed to remove very fine particulate from the air, typically 99.97% of particles larger than 0.3 micron. These filters usually consist of pleats of filter medium separated by rigid sheets of corrugated paper or aluminum foil; most high efficiency particulate air (HEPA) filters direct the flow of air in a uniform parallel pattern (laminar flow). HEPA filters are used to obtain very low particulate environments in places such as clean rooms, patient isolation chambers, and laminar air hoods; they are also used in high efficiency air cleaners. High-efficiency particulate air filters can remove most aerosolized biological agents and radioactive particles." + }, + { + "input": "Concept: L-Tyrosine, 3-hydroxy-alpha-methyl- (Antihypertensive Agents)", + "output": "Nitrogen and nitrogen compound described as a phenylalanine derivative and an aromatic amino acid decarboxylase inhibitor with antihypertensive activity. Methyldopa is a prodrug and is metabolized in the central nervous system. The antihypertensive action of methyldopa seems to be attributable to its conversion into alpha-methylnorepinephrine, which is a potent alpha-2 adrenergic agonist that binds to and stimulates potent central inhibitory alpha-2 adrenergic receptors. This results in a decrease in sympathetic outflow and decreased blood pressure." + }, + { + "input": "Concept: protein-containing complex remodeling (protein-containing complex subunit organization)", + "output": "Cell Function described as the acquisition, loss, or modification of macromolecules within a complex, resulting in the alteration of an existing complex." + }, + { + "input": "Concept: positive regulation of macrophage tolerance induction (regulation of macrophage tolerance induction)", + "output": "positive regulation of tolerance induction described as any process that increases the frequency, rate, or extent of B cell tolerance induction." + }, + { + "input": "Concept: 2-methylserine hydroxymethyltransferase activity (hydroxymethyl-, formyl- and related transferase activity)", + "output": "something described as catalysis of the reaction: 5,10-methylenetetrahydrofolate + D-alanine + H(2)O = (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine." + }, + { + "input": "Concept: CSB (Language)", + "output": "something described as a West Slavic language belonging to the Lechitic subgroup that is native to Poland." + }, + { + "input": "Concept: Pyrocatechols (Phenols)", + "output": "Organic Chemical described as a group of 1,2-benzenediols that contain the general formula R-C6H5O2." + }, + { + "input": "Concept: GALC (Gene or Genome)", + "output": "Hydrolase Gene described as this gene plays a role in hydrolysis of galactose ester bonds." + }, + { + "input": "Concept: FACT-BR Questionnaire (Clinical or Research Assessment Questionnaire)", + "output": "Clinical or Research Assessment Questionnaire described as a 50-item instrument that assesses general physical, social, emotional and functional well-being, as well as brain tumor-specific concerns." + }, + { + "input": "Concept: stage 0is bladder cancer (Stage 0 Bladder Carcinoma)", + "output": "Stage 0 Bladder Carcinoma described as stage 0is includes: Tis, N0, M0. Tis: Urothelial carcinoma in situ: \"flat tumor\". N0: No regional lymph node metastasis. M0: No distant metastasis." + }, + { + "input": "Concept: Spiritual nurse discharge facility assistance each 15 minutes (Health Care Activity)", + "output": "something described as assisting in processing the discharge of a patient from a facility consistent with his or her religious beliefs. Service is billed in 15-minute increments." + }, + { + "input": "Concept: Aletris farinosa / star grass / true unicorn grass (Western herbs and natural substances letter A)", + "output": "something described as star grass, true unicorn grass." + }, + { + "input": "Concept: DRRI-2 - I: Could Count on Family Advice (Intellectual Product)", + "output": "something described as deployment Risk and Resilience Inventory-2 (DRRI-2) During deployment: I could count on my family members or friends at home for good advice." + }, + { + "input": "Concept: DRRI1-B: Played Important Role in Family (Intellectual Product)", + "output": "something described as deployment Risk and Resilience Inventory-2 (DRRI-2) During childhood: I played an important role in my family." + }, + { + "input": "Concept: regulation of hormone metabolism (regulation of metabolism)", + "output": "something described as any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone." + }, + { + "input": "Concept: recess of the inferior colliculus (Body Part, Organ, or Organ Component)", + "output": "Body Part, Organ, or Organ Component described as the dorsal extension of the fourth ventricle that separates the cerebellum from the tectum of the midbrain in the mouse ( Paxinos-2001 )." + }, + { + "input": "Concept: Leporine ATG/Prednisone/Tacrolimus Regimen (Therapeutic or Preventive Procedure)", + "output": "Regimen Used to Treat Myelodysplastic Syndromes described as a regimen consisting of rabbit anti-thymocyte globulin, prednisone and tacrolimus that can be used in the treatment of myelodysplastic syndrome (MDS) and the prevention and treatment of graft rejection." + }, + { + "input": "Concept: Stage IVA Mycosis Fungoides and S\u00e9zary Syndrome (Neoplastic Process)", + "output": "something described as stage IVA includes: IVA1 (T1-4, N0-2, M0, B2); IVA2 (T1-4, N3, M0, B0-2). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. May further stratify into T1a (patch only) vs. T1b (plaque +/- patch). T2: Patches, papules, or plaques covering 10% or more of the skin surface. May further stratify into T2a (patch only) vs. T2b (plaque +/- patch). T3: One or more tumors (equal or greater than 1 cm diameter). T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. N3: Clinically abnormal peripheral lymph nodes; histopathology Dutch grades 3-4 or NCI LN4; clone positive or negative. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary) cells but does not meet the criteria of B2. B2: High blood tumor burden: 1000/microL Sezary cells or more with positive clone. (AJCC 7th ed.) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C88161\" active clinical trials using this agent." + }, + { + "input": "Concept: Film Dosing Unit (Quantitative Concept)", + "output": "Quantitative Concept described as a unit of presentation used to represent the quantity of product that is found in a single discrete entity where the pharmaceutical dose form is a type of film. Comment: For example, to describe the strength of an orodispersible film: \"contains 4 mg per film\"." + }, + { + "input": "Concept: subconjunctival haemorrhage (General visual observation)", + "output": "Hemorrhage described as blood between the conjunctiva and sclera." + }, + { + "input": "Concept: Radiology, Soft Tissue (Radiology Specialty)", + "output": "something described as a specialty concerned with the use of x-ray and other forms of radiant energy in the diagnosis and treatment of disease of soft tissue." + }, + { + "input": "Concept: Endoscopic Telescopes (Medical Device)", + "output": "something described as the viewing component (i.e., telescope, also known as scope) of an endoscope or laparoscope designed to permit the observation of internal tissues and/or organs of the human body otherwise inaccessible through natural canals, body cavities, or surgical orifices. These devices may consist of a hollow metal or plastic tube fitted with a lens system (frequently rodlike, closely spaced lenses) that permits viewing in a fixed, predetermined direction; typically a video camera attached to or replacing the eyepiece allows observation through a fiberoptic bundle on a video monitor. Other endoscopes and laparoscopes use a chip (charge-coupled device [CCD]) at the distal tip of the telescope to transmit the image through wires to the video processor without the use of additional lenses. Endoscopic telescopes may be specialized for the area in which they are operated (e.g., urinary or gastrointestinal tract endoscopes, arthroscopes, laparoscopes) and/or the procedure to be performed." + }, + { + "input": "Concept: Procedure Kit/Trays, Sitz Bath (Medical Device)", + "output": "Medical Device described as prepackaged collections of the necessary devices and supplies (either custom or standard) used to administer a limited bath by immersing the hips and buttocks of a patient in water or a water solution (i.e., Sitz baths). Items in these kits usually include a basin; an irrigation set with a bag, tubes, and usually a clamp; and towels. Some kits include additional equipment (e.g., a spray wand) and/or products (e.g., salts, herbs) to be mixed with the water. The basin usually is of an appropriate size and shape and is made of materials that permit its use on a standard toilet. These kits may be supplied in supporting trays (i.e., procedure trays) consisting of a flat-bottomed receptacle with a border around the periphery supporting all the instruments and supplies needed for the procedure; the trays are usually covered or wrapped. Sitz bath procedure kits and trays are used for hygiene and for external hydrotherapy to alleviate pain and/or discomfort caused by hemorrhoids, uterine cramps, labor, and/or conditions involving the pelvis, abdominal, and perineal areas. Reusable Sitz bath kits (typically including rigid plastic basins) and disposable kits (with inflatable plastic basins) are available; dedicated custom-made kits with specific characteristics may be also available." + }, + { + "input": "Concept: intestines mucosa (Organ component of intestine)", + "output": "Organ component of intestine described as innermost membrane of the four coats of the intestinal wall." + }, + { + "input": "Concept: hydrogen-sulfide acetyltransferase activity (S-acetyltransferase activity)", + "output": "S-acetyltransferase activity described as catalysis of the reaction: acetyl-CoA + S(2-) = CoA + thioacetate." + }, + { + "input": "Concept: negative regulation of 3-hydroxy-1,3,5(10)-estratrien-17-one secretion (Cell Function)", + "output": "negative regulation of lipid transport described as any process that stops, prevents or reduces the frequency, rate or extent of estrone secretion." + }, + { + "input": "Concept: COCCYX FRACTURE (Spinal Fractures)", + "output": "Fracture described as a traumatic break in the coccyx bone." + }, + { + "input": "Concept: Staphylococcus xylosus (Staphylococcus, coagulase negative)", + "output": "Genus staphylococcus described as a species of facultatively anaerobic, Gram positive, cocci shaped bacteria in the phylum Firmicutes. This species is positive for catalase and urease, and negative for coagulase and oxidase. It can ferment xylose, trehalose, arabinose, mannose, fructose, lactose, sucrose, turanose, and mannitol, but not maltose, turanose, cellobiose, or xylitol. S. xylosus is commensal on the skin of humans and animals, is used in the production of cheese and sausage and is a rare opportunistic pathogen in humans that can cause dermititis, urinary tract infections and bacteremia." + }, + { + "input": "Concept: Activating Transcription Factor 1 wt Allele (Gene or Genome)", + "output": "Gene or Genome described as human ATF1 wild-type allele is located in the vicinity of 12q13 and is approximately 57 kb in length. This allele, which encodes cyclic AMP-dependent transcription factor ATF-1 protein, plays a role in transcriptional regulation. Two translocations of this gene are associated with angiomatoid fibrous histiocytoma and clear cell sarcoma. Translocation t(12;16)(q13;p11.2) with the FUS gene and t(12;22)(q13;q12) with the EWSR1 gene are expressed as fusion proteins." + }, + { + "input": "Concept: Pituitary-Adrenal Function Tests (Laboratory Procedure)", + "output": "endocrine diagnosis described as tests that evaluate the adrenal glands controlled by pituitary hormones." + }, + { + "input": "Concept: aldaric acid metabolism (Molecular Function)", + "output": "Carbohydrate Metabolism described as the chemical reactions and pathways involving aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group." + }, + { + "input": "Concept: Hounsfield Unit (Quantitative Concept)", + "output": "Quantitative Concept described as term given to the dimensions of the quantifier of x-ray attenuation, CT number." + }, + { + "input": "Concept: Expectation Maximization Algorithm (Intellectual Product)", + "output": "Intellectual Product described as algorithm used in statistics for finding maximum likelihood estimates of parameters in probabilistic models, where the model depends on unobserved latent (inferred) variables." + }, + { + "input": "Concept: AG-1517 (Tyrphostin Compound)", + "output": "something described as a quinazoline derivative that selectively inhibits EGFR kinase activity and suppresses the growth of psoriatic keratinocytes." + }, + { + "input": "Concept: Hairy/Enhancer-of-Split Related With YRPW Motif Protein 1-Nuclear Receptor Coactivator 2 Fusion Protein (Biologically Active Substance)", + "output": "Amino Acid, Peptide, or Protein described as a fusion protein that is encoded by the HEY1/NCOA2 fusion gene. This protein contains the N-terminal basic helix-loop-helix domain of hairy/enhancer-of-split related with YRPW motif protein 1 fused to the C-terminal region of the nuclear receptor coactivator 2 protein, which includes its CREB binding and histone acetyl transferase domains." + }, + { + "input": "Concept: protein deglutamylation (peptidyl-glutamic acid modification)", + "output": "something described as the removal of a glutamate residue from a protein. Glutamate residues in proteins can be gene-encoded, or added as side chains during the protein modification process of polyglutamylation." + }, + { + "input": "Concept: Fibroblast Growth Factor Receptor 2 Isoform IIIb Positive (Positive Laboratory Test Result)", + "output": "Positive Laboratory Test Result described as an indication that FGFR2IIIb expression has been detected in a sample." + }, + { + "input": "Concept: Society, American Cancer (Professional Society)", + "output": "Professional Organization or Group described as a nationwide, community-based voluntary health organization, the largest private source of cancer research funds in the U.S. Headquartered in Atlanta, Georgia, the ACS has state divisions and more than 3,400 local offices. ACS provides information on cancer incidence, mortality, causes, manifestations, treatment, and prevention, as well as on cancer research and clinical trials, and promotes beneficial policies, laws, and regulations for patients and families affected by cancer." + }, + { + "input": "Concept: Vascular Patency (Organ or Tissue Function)", + "output": "something described as the degree to which BLOOD VESSELS are not blocked or obstructed." + }, + { + "input": "Concept: FIFTH CRANIAL NERVE DIS (Facial Neuralgia)", + "output": "something described as diseases of the trigeminal nerve or its nuclei, which are located in the pons and medulla. The nerve is composed of three divisions: ophthalmic, maxillary, and mandibular, which provide sensory innervation to structures of the face, sinuses, and portions of the cranial vault. The mandibular nerve also innervates muscles of mastication. Clinical features include loss of facial and intra-oral sensation and weakness of jaw closure. Common conditions affecting the nerve include brain stem ischemia, INFRATENTORIAL NEOPLASMS, and TRIGEMINAL NEURALGIA." + }, + { + "input": "Concept: RSSS01-Hugs You (Intellectual Product)", + "output": "something described as RAND Social Support Survey Instrument - How often is each of the following kinds of support available to you if you need it: Someone who hugs you." + }, + { + "input": "Concept: GUIDE, SURGICAL, INSTRUMENT (Medical Device)", + "output": "Device Component or Accessory described as devices designed to position and facilitate the operation of moving (i.e., guide) components of equipment and as guides during the performance of manual or endoscopic procedures improving their accuracy. These guides typically consist of a mechanical device that may be attached to instruments (e.g., drills, saws, snares) to facilitate the use of detachable components (i.e., drill bits, saw blades, snare wires) or to function as independent guides intended to lead small devices (e.g., needles) during manual (e.g., suturing) and endoscopic procedures." + }, + { + "input": "Concept: Transcription Factor TBP (Amino Acid, Peptide, or Protein)", + "output": "Biologically Active Substance described as TATA-box-binding protein (339 aa, ~38 kDa) is encoded by the human TBP gene. This protein is involved in both DNA binding and gene transcription initiation." + }, + { + "input": "Concept: BCR/ABL1 Fusion Protein with ABL1 NP 005148.2:p.L384M (Amino Acid, Peptide, or Protein)", + "output": "something described as a fusion protein encoded by the BCR/ABL1 fusion gene with ABL1 NM_005157.4:c.1150C>A mutation. This protein is comprised of the N-terminus of the breakpoint cluster region protein fused to almost the entire tyrosine-protein kinase ABL1 protein where the leucine at position 384 of the ABL1 protein has been replaced by methionine." + }, + { + "input": "Concept: RADIO-LABELED IRON METHOD, IRON (Medical Device)", + "output": "Medical Device described as an iron (non-heme) test system is a device intended to measure iron (non-heme) in serum and plasma. Iron (non-heme) measurements are used in the diagnosis and treatment of diseases such as iron deficiency anemia, hemochromatosis (a disease associated with widespread deposit in the tissues of two iron-containing pigments, hemosiderin and hemofuscin, and characterized by pigmentation of the skin), and chronic renal disease." + }, + { + "input": "Concept: NPI1-Other Signs of Depression (NPI Questionnaire Question)", + "output": "NPI Questionnaire Question described as neuropsychiatric Inventory (NPI) Does the patient show any other signs of depression or sadness?" + }, + { + "input": "Concept: Stage II Renal Pelvis and Ureter Cancer (Renal Pelvis and Ureter Cancer by AJCC v7 Stage)", + "output": "something described as stage II includes: T2, N0, M0. T2: Tumor invades the muscularis. N0: No regional lymph node metastasis. M0: No distant metastasis." + }, + { + "input": "Concept: Unspecified otosclerosis, unspecified ear (Korean Standard Classification of Disease Version 5)", + "output": "Diseases of the ear and mastoid process described as pathological condition of the bony labyrinth of the ear, in which there is formation of spongy bone; may cause bony ankylosis of the stapes, resulting in conductive hearing loss; cochlear otosclerosis may also develop, resulting in sensorineural hearing loss." + }, + { + "input": "Concept: Apophysis, Bony (Bone Tissue)", + "output": "Skeletal bone described as regular connective tissue, which consists of osteocytes and related cells, the intercellular matrix of which is ossified. Examples: woven bone, lamellar bone." + }, + { + "input": "Concept: pNGVL4a-CRT/E7(detox) DNA vaccine (Pharmacologic Substance)", + "output": "something described as a cancer vaccine consisting of the DNA plasmid pNGVL4a-A encoding calreticulin (CRT) linked to a detox form of human papillomavirus (HPV) type 16 E7 antigen, with potential immunomodulating and antineoplastic activities. Upon administration, this vaccine may generate a potent cytotoxic T-lymphocyte (CTL) response against E7-expressing tumor cells, resulting in tumor cell death. For E7(detox), the amino acids in E7 at positions 24 (cysteine to glycine) and 26 (glutamic acid to glycine) were substituted. CRT, a 46 kDa protein located in the lumen of the cell's endoplasmic reticulum (ER), may potentiate MHC class I presentation of HPV-16 E7 to E7-specific CD8-positive T cells. In addition, pNGVL4a-A contains two short immunostimulatory DNA sequences (ISS) in the noncoding region, which may elicit the production of IFN- and IL-12 in transfected keratinocytes and dermal antigen presenting cells (APCs), resulting in a potent T helper cell type 1 response." + }, + { + "input": "Concept: frozen joints (Other specific joint derangements)", + "output": "Limitation of joint mobility described as a reduction of joint mobility resulting from changes involving the articular surfaces. []" + }, + { + "input": "Concept: Monoclonal Antibody 3-275 (Immunologic Factor)", + "output": "Immunologic Factor described as a recombinant monoclonal antibody directed against the lymphocyte receptor CD2 with potential use in cancer immunotherapy. Activation of the CD2 molecule, one of several lymphocyte receptors, rapidly initiates signaling events regulating integrin-mediated cell adhesion." + }, + { + "input": "Concept: GP200-MR6 (Immunoprotein Gene)", + "output": "Receptor Gene described as this gene is involved in antigen capture." + }, + { + "input": "Concept: embolism; paradoxical (Thromboembolism)", + "output": "something described as blockage of an artery due to passage of a clot (THROMBUS) from a systemic vein to a systemic artery without its passing through the lung which acts as a filter to remove blood clots from entering the arterial circulation. Paradoxical embolism occurs when there is a defect that allows a clot to cross directly from the right to the left side of the heart as in the cases of ATRIAL SEPTAL DEFECTS or open FORAMEN OVALE. Once in the arterial circulation, a clot can travel to the brain, block an artery, and cause a STROKE." + }, + { + "input": "Concept: Thermal Loss Shields (Reusable Devices)", + "output": "Medical Device described as shields used for thermal protection against the loss of heat by the patient's body." + }, + { + "input": "Concept: ceramide catabolism (ceramide metabolic process)", + "output": "Molecular Function described as the chemical reactions and pathways resulting in the breakdown of ceramides, any N-acetylated sphingoid." + }, + { + "input": "Concept: International Troy Ounce (Quantitative Concept)", + "output": "something described as the non-SI unit of mass equal to 31.103 grams, 20 pennyweight, or 480 grains, or 0.083 pound." + }, + { + "input": "Concept: ABH Blood Groups (Classification)", + "output": "Blood Group described as the major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane." + }, + { + "input": "Concept: Refractory Female Reproductive System Carcinoma (Neoplastic Process)", + "output": "Refractory Malignant Female Reproductive System Neoplasm described as female reproductive system carcinoma that is resistant to treatment." + }, + { + "input": "Concept: Intercellular Adhesion Molecule 3 (Laboratory Procedure)", + "output": "Laboratory Procedure described as the determination of the amount of intercellular adhesion molecule 3 present in a sample." + }, + { + "input": "Concept: area FCBm of Bonin (Body Location or Region)", + "output": "something described as an area of cerebral cortex defined on the basis of cytoarchitecture in the macaque. The area labeled FCBm was described together with area FC of Bonin and area FCop of Bonin as \\\"a zone which surrounds the frontal lobe... anterior to the agranular cortex... which contains but a feeble granular layer.\\\" Because of \\\"the tendency for cells of iiic to become prominent,\\\" the authors regarded it as homologous to area FCBm of the human as defined by Economo ( Bonin-1947 )." + }, + { + "input": "Concept: Interleukin-15 (Interleukins)", + "output": "Lymphokines described as cytokine that stimulates the proliferation of T lymphocytes and shares biological activities with interleukin 2; it also can induce B lymphocyte proliferation and differentiation." + }, + { + "input": "Concept: diets (Nutrition function)", + "output": "Nutrition function described as food and drink regularly consumed or prescribed for a special reason. Used for human or animal populations." + }, + { + "input": "Concept: Phosphotungstic Acid (Tungsten Compounds)", + "output": "Phosphoric Acids described as tungsten hydroxide oxide phosphate. A white or slightly yellowish-green, slightly efflorescent crystal or crystalline powder. It is used as a reagent for alkaloids and many other nitrogen bases, for phenols, albumin, peptone, amino acids, uric acid, urea, blood, and carbohydrates." + }, + { + "input": "Concept: Ethane, 1,1'-oxybis(2,2,2-trifluoro)- (Stimulant)", + "output": "Organic Chemical described as a convulsant primarily used in experimental animals. It was formerly used to induce convulsions as a alternative to electroshock therapy." + }, + { + "input": "Concept: Increased projection of lower jaw (Mandibular displacement)", + "output": "Congenital Abnormality described as abnormal prominence of the chin related to increased length of the mandible." + }, + { + "input": "Concept: FACT-HEP Version 4 - Losing Hope Against Illness (FACT-HEP Version 4 Questionnaire Question)", + "output": "Intellectual Product described as functional Assessment of Cancer Therapy-Hepatobiliary Version 4 (FACT-HEP Version 4) Emotional Well-Being: I am losing hope in the fight against my illness." + }, + { + "input": "Concept: ATP-dependent oligogalacturonide transmembrane transporter activity (Molecular Function)", + "output": "ATPase-coupled oligosaccharide transmembrane transporter activity described as enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligogalacturonide(out) = ADP + phosphate + oligogalacturonide(in)." + }, + { + "input": "Concept: Night (Finding)", + "output": "something described as the chief complaint is noted to primarily occur between sunset and sunrise." + }, + { + "input": "Concept: Lymph Node Tissue (Tissue)", + "output": "Tissue described as tissue composed of specialized cells that are organized as a definite organ, situated along the course of lymphatic vessels, and consisting of an outer cortical and an inner medullary part. The lymph nodes are the main source of lymphocytes of the peripheral blood and serve as a defense mechanism by removing noxious agents, such as bacteria and toxins, and probably play a role in antibody production." + }, + { + "input": "Concept: creatinine homeostasis (Organ or Tissue Function)", + "output": "chemical homeostasis described as any biological process involved in the maintenance of an internal steady state of creatinine." + }, + { + "input": "Concept: 2-fluoro-alpha-methyl[1,1'-biphenyl]-4-acetic Acid (Propionic acid derivative anti-inflammatory agent)", + "output": "flurbiprofen described as a derivative of propionic acid, and a phenylalkanoic acid derivative of non-steroidal antiinflammatory drugs (NSAIDs) with analgesic, antiinflammatory and antipyretic effects. Flurbiprofen non-selectively binds to and inhibits cyclooxygenase (COX). This results in a reduction of arachidonic acid conversion into prostaglandins that are involved in the regulation of pain, inflammation and fever. This NSAID also inhibits carbonic anhydrase, thereby reducing the production of hydrogen and bicarbonate ions. Upon ocular administration, flurbiprofen may reduce bicarbonate ion concentrations leading to a decrease in the production of aqueous humor, thereby lowering intraocular pressure. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C508\" active clinical trials using this agent." + }, + { + "input": "Concept: periodontitis chronic generalized slight (Generalized chronic periodontitis)", + "output": "something described as chronic separation of the periodontal tissue from the root by 1-2 millimetres of clinical attachment loss in greater than 30% of sites as measured from the cementoenamel junction to the base of the probable pocket (gingival sulcus)." + }, + { + "input": "Concept: Complete duplication of the proximal phalanx of the second toe (Anatomical Abnormality)", + "output": "Duplication of the proximal phalanx of the 2nd toe described as complete duplication of proximal phalanx of second toe." + }, + { + "input": "Concept: Weight Unit (Unit by Category)", + "output": "Unit by Category described as an indication of the type of unit of measure being used to express a weight." + }, + { + "input": "Concept: Paced Tapping (Functional assessment)", + "output": "Functional assessment described as a cognitive test that is used to assess sensorimotor synchronization and timing of movement, where a subject produces a series of finger taps, at first in time with an external pacing stimulus and then continuing after the stimulus has ended." + }, + { + "input": "Concept: translation elongation factor activity (Genetic Function)", + "output": "Genetic Function described as functions in chain elongation during polypeptide synthesis at the ribosome." + }, + { + "input": "Concept: receptor tyrosine kinase (Protein Tyrosine Kinase)", + "output": "Protein Tyrosine Kinase described as a class of membrane receptors that contain protein tyrosine kinase activity. This enzymatic activity is integral to the function of the receptor as a signal transducer; the phosphorylation event alters the functional activity of its protein substrate." + }, + { + "input": "Concept: Recorders, Graphic, Physiologic (Medical Device)", + "output": "Physiologic monitoring recorder described as graphic recorders including sensors and amplifiers for measuring and recording two or more vital signs simultaneously (e.g., electrocardiogram and blood pressure). These recorders are commonly used in patients to assess their physical conditions." + }, + { + "input": "Concept: STREPTOCOCCUS VESTIBULARIS (Streptococcus salivarius group)", + "output": "Bacterium described as any bacterial organism that can be assigned to the species Streptococcus vestibularis." + }, + { + "input": "Concept: regulation of central tolerance induction (Biologic Function)", + "output": "Biologic Function described as any process that modulates the frequency, rate, or extent of central tolerance induction." + }, + { + "input": "Concept: ECOG Performance Status not Evaluated, not Provided or Available (CPTAC Questions)", + "output": "something described as the ECOG performance status was not evaluated or available." + }, + { + "input": "Concept: EEG with frontal focal spikes (Finding)", + "output": "EEG with focal spikes described as EEG with focal sharp transient waves of a duration less than 80 msec in the frontal region." + }, + { + "input": "Concept: mngie (Mitochondrial Encephalomyopathies)", + "output": "Chronic metabolic disorder described as syndrome with the association of gastrointestinal dysmotility, peripheral neuropathy, chronic progressive external ophthalmoplegia and leukoencephalopathy. The symptoms are progressive and the clinical picture is dominated by severe gastrointestinal disorders due to abnormal bowel motility. Morphological studies of the muscles reveal the presence of a low proportion of muscle fibres with mitochondrial proliferation (ragged-red fibres) or cytochrome c oxidase deficiency. Inherited in an autosomal recessive manner and is caused by mutations in the TYMP gene (22q13.32-qter)." + }, + { + "input": "Concept: ANTISERA, NEUTRALIZATION, COXSACKIEVIRUS A 1-24, B 1-6 (Indicator, Reagent, or Diagnostic Aid)", + "output": "Indicator, Reagent, or Diagnostic Aid described as coxsackievirus serological reagents are devices that consist of antigens and antisera used in serological tests to identify antibodies to coxsackievirus in serum. Additionally, some of these reagents consist of coxsackievirus antisera conjugated with a fluorescent dye that are used to identify coxsackievirus from clinical specimens or from tissue culture isolates derived from clinical specimens. The identification aids in the diagnosis of coxsackievirus infections and provides epidemiological information on diseases caused by these viruses. Coxsackieviruses produce a variety of infections, including common colds, meningitis (inflammation of brain and spinal cord membranes), herpangina (brief fever accompanied by ulcerated lesions of the throat), and myopericarditis (inflammation of heart tissue)." + }, + { + "input": "Concept: lacis cell proliferation (Cell Function)", + "output": "cell proliferation involved in kidney development described as the multiplication or reproduction of extraglomerular glomerular mesangium cells by cell division, resulting in the expansion of their population. Extraglomerular mesangial cells (also known as lacis cells, Goormaghtigh cells) are light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa." + }, + { + "input": "Concept: Starlings (Bird)", + "output": "Order Passeriformes described as the family Sturnidae, in the order PASSERIFORMES. The starling family also includes mynahs and oxpeckers." + }, + { + "input": "Concept: ADT01-Failed to Do as Expected (Intellectual Product)", + "output": "something described as alcohol Use Disorder Identification Test Self-Report Version (AUDIT) How often during the last year have you failed to do what was normally expected of you because of drinking?" + }, + { + "input": "Concept: Agar Dilution Method (Dilution technique)", + "output": "something described as a method to determine microbial susceptibility to antibiotics in which test bacteria is inoculated onto agar plates with serial dilutions of know quantities of antibiotics. The minimum inhibitory concentration of antibiotic is assessed." + }, + { + "input": "Concept: Expanded DRS-PI Caregiver Version - Make Sounds Not Understandable (Intellectual Product)", + "output": "something described as expanded Disability Rating Scale - Postacute Interview Caregiver Version (Expanded DRS-PI Caregiver Version) Does [name] only moan, groan or make other sounds that are not understandable?" + }, + { + "input": "Concept: IL 5 Receptors (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as cell surface receptors that are specific for INTERLEUKIN-5. They are heterodimeric proteins consisting of the INTERLEUKIN-5 RECEPTOR ALPHA SUBUNIT and the CYTOKINE RECEPTOR COMMON BETA SUBUNIT. Signaling from interleukin-5 receptors can occur through interaction of their cytoplasmic domains with SYNTENINS." + }, + { + "input": "Concept: Thickened elastic fibres in the dermis (Finding)", + "output": "Abnormal cutaneous elastic fiber morphology described as an increase of the diameter of elastic fibers in the dermis. []" + }, + { + "input": "Concept: Glasgow Coma Scale NINDS Version Clinical Classification Test Name (CDISC Clinical Classification Terminology)", + "output": "Intellectual Product described as test names of clinical classification questions associated with the Glasgow Coma Scale-NINDS Version (GCS NINDS Version) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: Truncal vagotomy (Transection of vagus)", + "output": "Division described as bilateral dissection of the abdominal branches of the vagus nerve. It is used frequently in the surgical management of duodenal and gastric ulcers, as well as in physiologic studies of gastrointestinal secretion and motility." + }, + { + "input": "Concept: ScheduledActivity (Activity)", + "output": "something described as an activity that is anticipated to occur at some time in the future and has been assigned a time or date when that activity is to be performed. EXAMPLE(S): An X-Ray scheduled for February 15 is in state \"Scheduled.\" If John is unable to have the X-Ray on that date, the X-Ray would either be rescheduled (remain in \"Scheduled\" state, but \"date\" attribute would change) or moved to state \"Canceled.\" OTHER NAME(S): NOTE(S):" + }, + { + "input": "Concept: Swati (Language)", + "output": "something described as a Niger-Congo Bantu language spoken by the Swazi people in Swaziland and South Africa." + }, + { + "input": "Concept: down-regulation of axial mesodermal cell fate specification (regulation of axial mesodermal cell fate specification)", + "output": "something described as any process that stops, prevents, or reduces the frequency, rate or extent of axial mesoderm cell fate specification." + }, + { + "input": "Concept: M Phase-Promoting Factor (Enzyme)", + "output": "Amino Acid, Peptide, or Protein described as protein kinase that drives both the mitotic and meiotic cycles in all eukaryotic organisms. In meiosis it induces immature oocytes to undergo meiotic maturation. In mitosis it has a role in the G2/M phase transition. Once activated by CYCLINS; MPF directly phosphorylates some of the proteins involved in nuclear envelope breakdown, chromosome condensation, spindle assembly, and the degradation of cyclins. The catalytic subunit of MPF is PROTEIN P34CDC2." + }, + { + "input": "Concept: Tandutinib (Antineoplastic Enzyme Inhibitor)", + "output": "Organic Chemical described as a piperazinyl quinazoline receptor tyrosine kinase inhibitor with antineoplastic activity. Tandutinib inhibits the autophosphorylation of FLT3 (FMS-Like Tyrosine kinase-3), c-KIT and PDGF (platelet-derived growth factor) receptor tyrosine kinases, thereby inhibiting cellular proliferation and inducing apoptosis." + }, + { + "input": "Concept: Adjunct Agent (Chemical Viewed Functionally)", + "output": "Chemical Viewed Functionally described as in cancer therapy, a drug or substance used in addition to the primary therapy." + }, + { + "input": "Concept: Sutures, Natural, Absorbable (Medical Device)", + "output": "Medical Device described as an absorbable surgical gut suture, both plain and chromic, is an absorbable, sterile, flexible thread prepared from either the serosal connective tissue layer of beef (bovine) or the submucosal fibrous tissue of sheep (ovine) intestine, and is intended for use in soft tissue approximation." + }, + { + "input": "Concept: Hanseniaspora valbyensis Klocker, 1912 (Fungus)", + "output": "Hanseniaspora described as any fungal organism that can be assigned to the species Hanseniaspora valbyensis." + }, + { + "input": "Concept: potassium ion uniporter activity (potassium ion transmembrane transporter activity)", + "output": "membrane potential driven uniporter activity described as catalysis of the active transport of a potassium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." + }, + { + "input": "Concept: Levocardia, NOS (Levocardia)", + "output": "Congenital heart disease described as congenital abnormalities in which the HEART is in the normal position (levocardia) in the left side of the chest but some or all of the THORAX or ABDOMEN viscera are transposed laterally (SITUS INVERSUS). It is also known as situs inversus with levocardia, or isolated levocardia. This condition is often associated with severe heart defects and splenic abnormalities such as asplenia or polysplenia." + }, + { + "input": "Concept: Esophageal Mucosa-Associated Lymphoid Tissue Lymphoma (Esophageal Non-Hodgkin Lymphoma)", + "output": "Neoplastic Process described as an extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue that arises from the esophagus with the bulk of the mass located in the esophagus." + }, + { + "input": "Concept: stage IIIA distal bile duct cancer (Stage III Distal Bile Duct Cancer AJCC v8)", + "output": "Stage III Distal Bile Duct Cancer AJCC v8 described as stage IIIA includes: (T1, N2, M0); (T2, N2, M0); (T3, N2, M0). T1: Tumor invading the bile duct wall with a depth less than 5 mm. T2: Tumor invading the bile duct wall with a depth of 5-12 mm. T3: Tumor invading the bile duct wall with a depth greater than 12 mm. N2: Metastasis in four or more regional lymph nodes. M0: No distant metastasis." + }, + { + "input": "Concept: Microbial EC50 Fold Change from Reference (Finding)", + "output": "something described as a fold change based on the concentration of a specific drug expected to produce 50 percent inhibition of the population growth or replication of a microbial organism. It is a ratio calculated by the EC50 Subject Result divided by the EC50 Reference Control Result." + }, + { + "input": "Concept: PODCI2-Use Assistive Devices for Sitting (PODCI Adolescent Parent-Reported Version Questionnaire Question)", + "output": "something described as pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported Version (PODCI Adolescent Parent-Reported Version) How often does your child use assistive devices (such as braces, crutches, or wheelchair) for sitting and standing?" + }, + { + "input": "Concept: vindoline synthesis (tertiary alcohol biosynthetic process)", + "output": "something described as the chemical reactions and pathways resulting in the formation of vindoline." + }, + { + "input": "Concept: Fibroblast Growth Factor Family Alteration Positive (Laboratory or Test Result)", + "output": "Positive Laboratory Test Result described as indicates that mutation, overexpression or rearrangement of an FGF family member has been detected in a sample." + }, + { + "input": "Concept: Radiotherapy Systems, Linear Accelerator, Intraoperative, Mobile (Radiotherapy Systems, Linear Accelerator)", + "output": "Radiotherapy Systems, Linear Accelerator described as radiotherapy systems designed to administer ionizing radiation during a surgical procedure by means of electron beams of varying energies and/or high-energy photons using a mobile linear accelerator (linac) as a generator. These systems include a dedicated lightweight mobile linear accelerator that is mounted on a motorized gantry attached to a stand mounted on the transportation unit. The system can be transported from one to another conventional unshielded or reduce-shielding operating rooms; to prevent radiation exposure in adjacent rooms the systems may limit the beam energy to values limited to 10-12 mega-electron-volt, making they only able for targets to a few centimeter depth. Mobile intraoperative linear accelerators main components are similar to standard linear accelerators (i.e., a modulator, an electron gun, a radio-frequency power source, and an accelerator guide); the electron beam is further collimated to the desired size by on of a set of applicators (e.g., diameters from 3 to 10 cm) inserted into the patient. Some systems include adjustable gantries that can tilt and move in the horizontal plane. Mobile intraoperative radiotherapy systems are intended to provide a high dose of radiation in a single procedure with high target accuracy and low risk of damage to the adjacent tissues." + }, + { + "input": "Concept: Magnifying spectacles (Eyeglasses)", + "output": "Spectacle lens described as magnifying spectacles are devices that consist of spectacle frames with convex lenses intended to be worn by a patient who has impaired vision to enlarge images." + }, + { + "input": "Concept: Stage IV Lip and Oral Cavity Squamous Cell Carcinoma AJCC v7 (Lip and Oral Cavity Squamous Cell Carcinoma)", + "output": "Neoplastic Process described as stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0);. IVB (Any T, N3, M0); (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a (lip): Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i.e., chin or nose. T4a (oral cavity): Tumor invades adjacent structures (e.g., through cortical bone, into deep [extrinsic] muscles of tongue, maxillary sinus, skin of face). T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N2a: Metastasis in a single ipsilateral lymph node more than 3 cm but not more than 6 cm in dimension. N2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension. N2c: Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M1: Distant metastasis." + }, + { + "input": "Concept: NPI1I (NPI Questionnaire Question)", + "output": "something described as neuropsychiatric Inventory - Does the patient get irritated and easily disturbed? Are his/her moods very changeable? Is he/she abnormally impatient? We do not mean frustration over memory loss or inability to perform usual tasks; we are interested to know if the patient has abnormal irritability, impatience, or rapid emotional changes different from his/her usual self." + }, + { + "input": "Concept: Hepatitis, Animal (Disease or Syndrome)", + "output": "Animal Diseases described as INFLAMMATION of the LIVER in non-human animals." + }, + { + "input": "Concept: Prostate Cancer Pathway (Cancer Pathway)", + "output": "Cancer Pathway described as the identification of key molecular alterations in prostate-cancer cells implicates carcinogen defenses (GSTP1), growth-factor-signaling pathways (NKX3.1, PTEN, and p27), and androgens (AR) as critical determinants of the phenotype of prostate-cancer cells. Glutathione S-transferases (GSTP1) are detoxifying enzymes that catalyze conjunction of glutathione with harmful, electrophilic molecules, thereby protecting cells from carcinogenic factors. Cells of prostatic intraepithelial neoplasia, devoid of GSTP1, undergo genomic damage mediated by such carcinogens. NKX3.1, PTEN, and p27 regulate the growth and survival of prostate cells in the normal prostate. Inadequate levels of PTEN and NKX3.1 lead to a reduction in p27 levels and to increased proliferation and decreased apoptosis. After therapeutic reduction in the levels of testosterone and dihydrotestosterone, the emergence of androgen-independent prostate cancer has been associated with mutations in the androgen receptor (AR) that permit receptor activation by other ligands, increased expression of androgen receptors accompanying AR amplification, and ligand-independent androgen-receptor activation." + }, + { + "input": "Concept: Liposomal Acid Lipase Deficiency, Wolman Type (Disorder of lipid storage and metabolism)", + "output": "Inborn Errors of Metabolism described as a very rare, autosomal recessive inherited lysosomal storage disease caused by mutations in the LIPA gene. Signs and symptoms appear in infancy and include developmental delay, vomiting, abdominal distention, hepatosplenomegaly, jaundice, anemia, steatorrhea, and calcification of the adrenal glands." + }, + { + "input": "Concept: Bone Trabeculae (Tissue)", + "output": "Bone Tissue, Human described as anastomosing, needle-like bony structures which create a meshwork of spaces filled with bone marrow." + }, + { + "input": "Concept: E-45 DERMATOPHYTOSES (Skin and subcutaneous tissue fungal infections)", + "output": "Tinea described as fungal infection of the skin." + }, + { + "input": "Concept: Comprehensive Eye Disorder Gene Panel Reagents (IVD Panels, Human Genetics, Eye Disorder)", + "output": "IVD Panels, Human Genetics, Eye Disorder described as molecular assay reagents intended to identify gene variants in the majority of genes known to be associated with eye disorders, a collection of conditions affecting ocular structure and/or function. Genetic variants at multiple loci have been associated with eye disorders. These reagents are intended to detect various types of genetic changes (e.g., deletions, duplications, insertions, single nucleotide polymorphisms) in the majority of eye disorder-associated loci simultaneously." + }, + { + "input": "Concept: 23S rRNA (guanine(2445)-N(2))-methyltransferase activity (rRNA (guanine-N2-)-methyltransferase activity)", + "output": "rRNA (guanine-N2-)-methyltransferase activity described as catalysis of the reaction: S-adenosyl-L-methionine + guanosine(2445) in 23S rRNA = N(2)-methylguanosine(2445) in 23S rRNA + S-adenosyl-L-homocysteine." + }, + { + "input": "Concept: Retinal structure (Visual pathway structure)", + "output": "something described as the ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent." + }, + { + "input": "Concept: Prostate Cancer Pathologic Regional Lymph Nodes TNM Finding v6 (Finding)", + "output": "Prostate Cancer Pathologic TNM Finding v6 described as a pathologic finding about one or more characteristics of prostate cancer, following the rules of the TNM AJCC v6 classification system as they pertain to staging of regional lymph nodes. TNM pathologic regional lymph nodes findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery." + }, + { + "input": "Concept: QS-FPSR TESTCD (CDISC Questionnaire Terminology)", + "output": "CDISC Questionnaire Terminology described as faces Pain Scale - Revised test code." + }, + { + "input": "Concept: B-lymphocyte proliferation (lymphocyte proliferation)", + "output": "lymphocyte proliferation described as the expansion of a B cell population by cell division. Follows B cell activation." + }, + { + "input": "Concept: Pathologic Ab-Ig Protein (Immunologic Factor)", + "output": "something described as pathologic Ab-Ig Proteins are immunoglobulin-related (IgA, IgD, IgE, IgG, IgM antibody) glycoproteins characteristically found in patients with multiple myeloma, infectious diseases, rheumatoid arthritis and other connective tissue diseases, or systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease." + }, + { + "input": "Concept: CC-WHO Clinical Staging of HIV/AIDS for Adults and Adolescents TEST (CDISC Clinical Classification Terminology)", + "output": "CDISC Clinical Classification Terminology described as test names of clinical classification questions associated with the World Health Organization Clinical Staging of HIV/AIDS for Adults and Adolescents (WHO Clinical Staging of HIV/AIDS for Adults and Adolescents) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: rhamnose-binding lectin family protein binding (Molecular Function)", + "output": "Protein Binding described as interacting selectively and non-covalently with any member of the rhamnose-binding lectin (RBL) family, a family of animal lectins that show specific binding activities to L-rhamnose or D-galactose." + }, + { + "input": "Concept: MOAB Hu3S193 (Immunologic Factor)", + "output": "Monoclonal Antibodies described as a humanized monoclonal antibody directed against the Lewis Y antigen, a tumor-associated epithelial antigen, with potential antineoplastic activity. Following binding, monoclonal antibody Hu3S193 triggers an antibody-dependent cell-mediated cytotoxicity in cells expressing Lewis Y antigen." + }, + { + "input": "Concept: Tyrosine-Protein Kinase Met Ser1236Arg (Cell or Molecular Dysfunction)", + "output": "Cell or Molecular Dysfunction described as a change in the amino acid residue at position 1236 in the hepatocyte growth factor receptor protein where serine has been replaced by arginine." + }, + { + "input": "Concept: Protocol Approval Date (Approval Date)", + "output": "something described as the date on which a version of the protocol was finalized or approved by the sponsor." + }, + { + "input": "Concept: alpha-actinin binding (Molecular Function)", + "output": "actinin binding described as interacting selectively and non-covalently with alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats." + }, + { + "input": "Concept: Chinese Crested dog breed (Mammal)", + "output": "Toy Breed described as a sweet and slender dog with spotted pink skin. There are two distinct varieties: one is hairless except for its feet, head, and tail, and is called the Hairless. The other is called the Powder Puff and has a long coat. Coats may be numerous colors, and can be solid, mixed, or spotted all over. The average height is 12 inches and weight is not over 10 pounds." + }, + { + "input": "Concept: Cedecea neteri (Bacterium)", + "output": "Cedecea described as a species of facultatively anaerobic, Gram-negative, bacilli assigned to the phylum Proteobacteria. This species is motile, non-spore forming, catalase positive, oxidase negative, lipase positive, indole negative, ornithine decarboxylase negative, ferments sucrose reduces nitrate, does not produce hydrogen sulfide, and hydrolyzes esculin. C. neteri is especially pathogenic to immunocompromised patients, causing super infections and bacteremia." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Serology, Virus, Measles, IgM Antibody (Medical Device)", + "output": "IVD Test Reagent/Kits, Serology, Virus, Measles described as serology reagents intended to detect immunoglobulin M (IgM) antibodies to measles virus, a single-stranded RNA enveloped virus of the genus Paramyxovirus, family Paramyxoviridae. This virus is the etiologic agent of measles, an acute, usually benign infection characterized by coryza, cervical lymphoid hyperplasia, conjunctivitis, harassing cough, malaise, fever, and, finally, skin eruption (rash)." + }, + { + "input": "Concept: WD5-Walking a Long Distance (WHODAS 2.0 36-item Version Interviewer-administered Questionnaire Question)", + "output": "something described as world Health Organization Disability Assessment Schedule 2.0 36-item Version Interviewer-administered (WHODAS 2.0 36-item Version Interviewer-administered) In the past 30 days, how much difficulty did you have in: Walking a long distance such as a kilometre [or equivalent]?" + }, + { + "input": "Concept: Producer (Population Group)", + "output": "something described as a person or group that creates or manufactures something." + }, + { + "input": "Concept: Abdomen (Chest Pain)", + "output": "Finding described as the location of the radiating chest pain is in the abdomen." + }, + { + "input": "Concept: regulation of myeloid cell differentiation (regulation of hemopoiesis)", + "output": "regulation of cell differentiation described as any process that modulates the frequency, rate or extent of myeloid cell differentiation." + }, + { + "input": "Concept: Focal aware orofacial automatism seizure (Focal aware automatism seizure)", + "output": "Focal orofacial automatism seizure described as a type of focal automatism seizure characterized by orofacial automatisms at onset and during which awareness is fully retained throughout." + }, + { + "input": "Concept: 13-lipoxin reductase activity (Molecular Function)", + "output": "Molecular Function described as definition: Catalysis of the reaction: 15-oxolipoxin A4 + NAD(P)H + H+ = 13,14-dihydro-15-oxolipoxin A4 + NAD(P)+." + }, + { + "input": "Concept: Mature Lymphocyte (Lymphocyte)", + "output": "something described as a white blood cell that matures in the primary lymphoid organs and then circulates through the lymph system to the secondary lymphoid tissues where it interacts with antigens. A mature lymphocyte varies in size from 7 to 15 micrometer in diameter and is round or ovoid, but may be notched or slightly indented. The chromatin is generally diffusely dense and nucleoli are not usually visible." + }, + { + "input": "Concept: Mixed tumor, malignant (Neoplasms, Complex and Mixed)", + "output": "Complex mixed AND/OR stromal neoplasm described as a malignant neoplasm composed of epithelial and/or myoepithelial cells and a mesenchymal component. A general term for which the transformed cell types have not been specified." + }, + { + "input": "Concept: BOD1L1 (DNA repair protein)", + "output": "something described as biorientation of chromosomes in cell division protein 1-like 1 (3051 aa, ~330 kDa) is encoded by the human BOD1L1 gene. This protein plays a role in promoting the repair of damaged replication forks." + }, + { + "input": "Concept: 2D mode ultrasound (Ultrasound - action)", + "output": "Ultrasound - action described as 2D, B-mode, B-scan image type" + }, + { + "input": "Concept: Genes (genetics and heredity)", + "output": "GENES: GENERAL TERMS described as a functional unit of heredity which occupies a specific position on a particular chromosome and serves as the template for a product that contributes to a phenotype or a biological function." + }, + { + "input": "Concept: Infection, Intra-Abdominal (Infection by site)", + "output": "Abdominal and gastrointestinal infections described as infection in the abdominal cavity resulting from injury, acute intestinal inflammation (e.g., acute appendicitis), intestinal perforation, or complication of abdominal surgery." + }, + { + "input": "Concept: upregulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway (positive regulation of intracellular protein transport)", + "output": "something described as any process that activates or increases the frequency, rate or extent of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway." + }, + { + "input": "Concept: Autosomal recessive cerebellar ataxia, epilepsy, intellectual disability syndrome due to TUD deficiency (Intellectual Disability)", + "output": "Ataxias, Hereditary described as a rare hereditary ataxia characterised by early onset symptomatic generalised epilepsy, progressive cerebellar ataxia resulting in significant difficulties to walk or wheelchair dependency, and intellectual disability. There is evidence the disease is caused by homozygous mutation in the TDP2 gene on chromosome 6p22." + }, + { + "input": "Concept: PROGRAMS REGIONAL MED (Governmental or Regulatory Activity)", + "output": "Governmental or Regulatory Activity described as coordination of activities and programs among health care institutions within defined geographic areas for the purpose of improving delivery and quality of medical care to the patients. These programs are mandated under U.S. Public Law 89-239." + }, + { + "input": "Concept: Nauru language (Austronesian Language)", + "output": "Austronesian Language described as an Austronesian language spoken in the country of Nauru." + }, + { + "input": "Concept: TSCYC1-Saying He or She Wanted to Die (Intellectual Product)", + "output": "something described as trauma Symptom Checklist for Young Children (TSCYC) Please indicate how often the child has done, felt, or experienced each of the following things in the last month: Saying he or she wanted to die or be killed." + }, + { + "input": "Concept: Aviation (Occupation or Discipline)", + "output": "Occupation or Discipline described as design, development, manufacture, and operation of heavier-than-air AIRCRAFT." + }, + { + "input": "Concept: bladder carcinoma gall (Malignant Neoplasms)", + "output": "Carcinoma described as cancer that forms in tissues of the gallbladder. The gallbladder is a pear-shaped organ below the liver that collects and stores bile (a fluid made by the liver to digest fat). Gallbladder cancer begins in the innermost layer of tissue and spreads through the outer layers as it grows." + }, + { + "input": "Concept: placenta percreta (Placenta Accreta)", + "output": "Pathologic Function described as histologically-confirmed deep attachment of the placenta into the myometrium and serosa. It may further extend into an adjacent organ such as the bladder." + }, + { + "input": "Concept: DNA polymerase III, DnaX subcomplex location (Cell Component)", + "output": "something described as a heptamer that includes the tau and gamma products of the dnaX gene and the chi/psi subcomplex. Confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands." + }, + { + "input": "Concept: Prostate Cancer Outcomes Study (Patient Oriented Research)", + "output": "Patient Oriented Research described as a study initiated in 1994 by researchers at the National Cancer Institute (NCI) to look at the impact that treatments for primary prostate cancer have on the quality of life of patients. PCOS is the first systematic evaluation of health-related quality-of-life issues for prostate cancer patients conducted on a multiregional scale." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Immunoassay, Rapid Test, Cardiac Marker, Troponin I (IVD Test Reagent/Kits, Immunoassay, Rapid Test, Cardiac Marker)", + "output": "Medical Device described as immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (usually whole blood) in a short period of time, typically several minutes, to determine the circulating inhibiting subunit of cardiac troponin (cTnI). The level of liberated troponin I is used as a highly specific marker of ischemic heart injuries (e.g., as the result of myocardial infarction)." + }, + { + "input": "Concept: IPA0324A (Intellectual Product)", + "output": "Intellectual Product described as international Physical Activity Questionnaire (August 2002) Long Last 7 Days Self-Administered Format (IPAQ Long Last 7 Days Self-Administered Format Version) During the last 7 days, on how many days did you do moderate physical activities like bicycling at a regular pace, swimming at a regular pace, and doubles tennis in your leisure time?: days per week." + }, + { + "input": "Concept: Lyophilisate and Solvent for Oculonasal Suspension Dosage Form (Biomedical or Dental Material)", + "output": "Biomedical or Dental Material described as lyophilisate (freeze-dried powder) and solvent intended for the preparation of an oculonasal suspension, for veterinary use, by dispersing the lyophilisate in the solvent." + }, + { + "input": "Concept: Tunica media of vessel (Vascular Smooth Muscle Tissue)", + "output": "General anatomical term described as the middle layer of an artery" + }, + { + "input": "Concept: penetrance (Phenotype)", + "output": "Phenotype described as a characteristic of a genotype; it refers to the likelihood that a clinical condition will occur when a particular genotype is present." + }, + { + "input": "Concept: Hypopharyngeal Cancer Pathologic Regional Lymph Nodes TNM Finding v7 (Hypopharyngeal Cancer Pathologic TNM Finding v7)", + "output": "Hypopharyngeal Cancer Pathologic TNM Finding v7 described as a pathologic finding about one or more characteristics of hypopharyngeal cancer, following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes. Metastases at level VII are considered regional lymph node metastases." + }, + { + "input": "Concept: INTRAOP PERIOD (Operative Surgical Procedures)", + "output": "Operative Surgical Procedures described as the period during a surgical operation." + }, + { + "input": "Concept: HAI Pump (Infusion Pumps, Implantable)", + "output": "Medical Device described as a pump designed to adminster chemotherapy directly to the liver via the hepatic artery." + }, + { + "input": "Concept: Corynebacterium renale type II (Bacterium)", + "output": "Bacterium described as a species of aerobic or facultatively anaerobic, Gram-positive, coryneform, pleomorphic bacilli assigned to the phylum Actinobacteria. This species is nonmotile, non-spore forming, catalase and urease positive, oxidase and indole negative, reduces nitrate and nitrite, hydrolyzes hippurate and starch, but not gelatin or casein, and does not produce hydrogen sulfide. C. pilosum causes urinary tract infection and pyelonephritis." + }, + { + "input": "Concept: Stage III Retroperitoneal Sarcoma AJCC v8 (Retroperitoneal Sarcoma by AJCC v8 Stage)", + "output": "Retroperitoneal Sarcoma by AJCC v8 Stage described as stage III includes: IIIA: (T2, N0, M0, G2, G3); IIIB: (T3, T4, N0, M0, G2, G3); (Any T, N1, M0, Any G). T2: Tumor measuring more than 5 cm and less than or equal to 10 cm in greatest dimension. T3: Tumor measuring more than 10 cm and less than or equal to 15 cm in greatest dimension. T4: Tumor measuring more than 15 cm in greatest dimension. N0: No regional lymph node metastasis or unknown lymph node status. N1: Regional lymph node metastasis. M0: No distant metastasis. G2: Total differentiation, mitotic count and necrosis score of 4 or 5. G3: Total differentiation, mitotic count and necrosis score of 6, 7, or 8." + }, + { + "input": "Concept: Iobenguane I 131 (Radioisotopes)", + "output": "Radioisotopes described as an I 131 radioiodinated synthetic analogue of the neurotransmitter norepinephrine. Iobenguane localizes to adrenergic tissue and, in radioiodinated forms, may be used to image or eradicate tumor cells that take up and metabolize norepinephrine." + }, + { + "input": "Concept: Paced Tapping - Reciprocal Interval Self Trial (Intellectual Product)", + "output": "something described as paced Tapping - The reciprocal of the standard deviation of the intertap intervals within the self-paced tapping phase of Trial n." + }, + { + "input": "Concept: Ileal Neuroendocrine Tumor (Small Intestinal Neuroendocrine Tumor)", + "output": "Neoplastic Process described as a well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the ileum." + }, + { + "input": "Concept: EPIC214 (Intellectual Product)", + "output": "EPIC-CP Questionnaire Question described as expanded Prostate Cancer Index Composite for Clinical Practice (EPIC-CP) Sexual symptom score." + }, + { + "input": "Concept: Level 3 Non-reassuring Fetal Status (GAIA Non-Reassuring Fetal Status Level of Diagnostic Certainty)", + "output": "GAIA Non-Reassuring Fetal Status Level of Diagnostic Certainty described as level 3 Non-reassuring Fetal Status is defined by the presence of the following criteria: A fetal heart pattern that is detected via intermittent auscultation, and that is suggestive of fetal hypoxia, including the following requirements that must be met: a) Baseline fetal heart rate less than 110 bpm or greater than 160 bpm; b) Presence of repetitive or prolonged (greater than 3 minutes) decelerations; c) More than five contractions in a ten minute period." + }, + { + "input": "Concept: icosanoid metabolism (Molecular Function)", + "output": "fatty acid derivative metabolic process described as the chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids." + }, + { + "input": "Concept: DMPC (Drug vehicle)", + "output": "Pharmacologic Substance described as a synthetic phospholipid used in liposomes and lipid bilayers for the study of biological membranes." + }, + { + "input": "Concept: inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity (inositol tetrakisphosphate phosphatase activity)", + "output": "inositol tetrakisphosphate phosphatase activity described as catalysis of the reaction: inositol-1,3,4,6-tetrakisphosphate + H2O = inositol-1,3,4-trisphosphate + phosphate." + }, + { + "input": "Concept: Melanoma of the Uvea (Neoplastic Process)", + "output": "Eye Neoplasms described as a rare cancer of melanocytes (cells that produce the pigment melanin) found in the eye." + }, + { + "input": "Concept: Emergency contraceptive drugs (HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE)", + "output": "something described as high doses of contraceptive substances that can be taken before, the morning after, or up to five days after the unprotected vaginal intercourse." + }, + { + "input": "Concept: Distribution, Animal (Social Behavior)", + "output": "something described as a process by which animals in various forms and stages of development are physically distributed through time and space." + }, + { + "input": "Concept: Sequence Read Coverage (Quantitative Concept)", + "output": "Quantitative Concept described as the number of times a particular locus (site, nucleotide, amplicon, region) was sequenced." + }, + { + "input": "Concept: Third ventricle structure (Entire ventricle of brain)", + "output": "Space of ventricular system of brain described as a centrally placed component of the ventricular system of the brain located in the diencephalon. Cerebrospinal fluid from the lateral ventricles flows into the third ventricle via the foramina of Monroe and exits the third ventricle via the aqueduct of Sylvius. The thalamus and hypothalamus border the lateral walls of the third ventricle." + }, + { + "input": "Concept: RNA elongation from Pol II promoter (Genetic Function)", + "output": "Genetic Function described as the extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." + }, + { + "input": "Concept: CREB3L2-PPARgamma Fusion Gene (Gene or Genome)", + "output": "Gene or Genome described as a fusion gene that results from a chromosomal translocation t(3;7)(p25;q34) which fuses exon 1 and 2 of the CREB3L2 gene with exons 1-6 of the PPARG gene. This rearrangement is associated with thyroid follicular carcinoma." + }, + { + "input": "Concept: PG-S1 (Biologically Active Substance)", + "output": "Extracellular Matrix Proteins described as biglycan (368 aa, ~42 kDa) is encoded by the human BGN gene. This protein plays a role in connective tissue structure." + }, + { + "input": "Concept: malonic semialdehyde dehydrogenase activity (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)", + "output": "Molecular Function described as catalysis of the reaction: 3-oxopropanoate + NAD(P)+ + H2O = malonate + NAD(P)H + H+." + }, + { + "input": "Concept: Adult human body (Anatomic structures)", + "output": "Anatomic structures described as anatomical structure, which is the aggregate manifestation of an individual member of the species Homo sapiens; it is completely surrounded by skin. Examples: There is only one human body." + }, + { + "input": "Concept: Substance Use Subcategory (Subcategory)", + "output": "Subcategory described as classification of substance use data." + }, + { + "input": "Concept: Hypocystinemia (Abnormal circulating cysteine concentration)", + "output": "Finding described as a decreased amount of cystine in the blood." + }, + { + "input": "Concept: Tuberculinum, nosode of tuberculosis (Organic Chemical)", + "output": "Pharmacologic Substance described as nosode of tuberculosis." + }, + { + "input": "Concept: positive regulation of expression of histone-encoding gene (Genetic Function)", + "output": "regulation of histone gene expression described as any process that increases the frequency, rate or extent of expression of a histone-encoding gene. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein." + }, + { + "input": "Concept: atlantoaxial instability (Disease or Syndrome)", + "output": "Finding of cervical spine described as abnormally increased movement at the junction between the first cervical (atlas) and the second cervical (axis) vertebrae as a result of either a bony or ligamentous anomaly." + }, + { + "input": "Concept: beta-arrestin 1 (Amino Acid, Peptide, or Protein)", + "output": "Biologically Active Substance described as a beta-arrestin that functions in the down-regulation of signaling by G-PROTEIN-COUPLED RECEPTORS. It is also a major regulator of INSULIN signaling via the ERK 1-2 PATHWAY, and many other signaling processes, especially in NEURONS and LEUKOCYTES." + }, + { + "input": "Concept: Probes, Electrothermal Cautery, Covered (Medical Device)", + "output": "something described as electrothermal cautery probes in which the heating component (e.g., a high-resistance wire) is encased in a probe cover. They do not deliver electrical current to tissue. The cover is usually made of a nonstick material to facilitate its manipulation and prevent it from pulling away coagulated tissue when retracted. Covered electrocautery probes are used mainly for coagulation and/or control of bleeding during minor surgical procedures." + }, + { + "input": "Concept: Bowel Control Scale Questionnaire Test Name (Intellectual Product)", + "output": "something described as bowel Control Scale test name." + }, + { + "input": "Concept: Mental retardation, X-linked, with dystonic movements, ataxia, and seizures (Disease or Syndrome)", + "output": "Genetic Diseases, X-Linked described as mental retardation syndrome with episodic dystonic spasms of the hands and dysarthria." + }, + { + "input": "Concept: Sarcoma of the Meninges (Meningeal Neoplasms)", + "output": "Meningeal Neoplasms described as a rare sarcoma arising from the meninges." + }, + { + "input": "Concept: geldanamycin,17-demethoxy-17-[[2-(dimethylamino)ethyl]amino]-,monohydrochloride (Geldanamycin Analogue)", + "output": "Organic Chemical described as the hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction." + }, + { + "input": "Concept: Esmolol product (Adrenergic beta-1 Receptor Antagonists)", + "output": "Adrenergic beta-1 Receptor Antagonists described as the hydrochloride salt form of esmolol, a short, rapid-acting, selective beta-adrenergic receptor blocker, devoid of intrinsic sympathomimetic activity, and with anti-arrhythmic, antihypertensive and potential analgesic activities. Upon intravenous administration, esmolol binds to and blocks the beta-1 receptor in the myocardium thereby preventing the action of epinephrine and norepinephrine. This leads to a reduction in the force and rate of cardiac contractions and thereby preventing tachycardia, arrythmias and/or hypertension. At higher doses, esmolol also blocks beta-2 receptors located in bronchial and vascular smooth muscle, thereby leading to smooth muscle relaxation. In addition, esmolol exerts a peripheral analgesic effect and intraoperative use of this agent may decrease the amount of opioid administration postoperatively. As the ester moiety in esmolol is rapidly hydrolyzed byplasma esterases, this agent has a very short half-life. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C72617\" active clinical trials using this agent." + }, + { + "input": "Concept: 67 kDa Laminin Receptor (Amino Acid, Peptide, or Protein)", + "output": "something described as 67 kDa laminin receptor is a homodimer of 40S ribosomal protein SA. This cell surface receptor binds laminin and may interact with major prion protein." + }, + { + "input": "Concept: System Of Record Name (Name)", + "output": "something described as a non-unique textual identifier for the system that assigned the identifier." + }, + { + "input": "Concept: Lap (Laparoscopy)", + "output": "Laparoscopy described as examination of abdominal interior with a laparoscope." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, ARSA (Medical Device)", + "output": "Medical Device described as molecular assay reagents intended to identify mutations in the arylsulfatase A (ARSA) gene, located at chromosome 22q13.33, which encodes for the enzyme lysosomal arylsulfatase A that hydrolyzes ester bonds in cerebroside sulfates. Mutations at this locus have been identified in patients with metachromatic leukodystrophy (MLD) and multiple sulfatase deficiency (MSD)." + }, + { + "input": "Concept: Self-Management: Anticoagulation Therapy (Health management)", + "output": "Health management described as personal actions to manage therapy to maintain blood clotting time within a prescribed range and prevent complications" + }, + { + "input": "Concept: A-Inhibin Subunit (Amino Acid, Peptide, or Protein)", + "output": "something described as inhibin alpha chain (366 aa, ~40 kDa) is encoded by the human INHA gene. This protein is involved in the negative regulation of the secretion of follitropin by the pituitary gland." + }, + { + "input": "Concept: Gamma-tocopherol (Vitamin)", + "output": "tocopherol described as the orally bioavailable gamma form of the naturally-occurring fat-soluble vitamin E, found in certain nuts and seeds, with potential antioxidant activity. Although the exact mechanism of action of this tocopherol has yet to be fully identified, gamma-tocopherol appears to have the ability to scavenge free radicals, thereby protecting against oxidative damage. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C68317\" active clinical trials using this agent." + }, + { + "input": "Concept: Timopentina (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as a synthetic pentapeptide which is the active site of the naturally occurring hormone thymopoietin with immunomodulating properties. Thymopentin enhances the production of thymic T cells and may help restore immunocompetence in immunosuppressed subjects. This agent also augments the effects of ionizing radiation by arresting cancer cells in the G2/M phase of the cell cycle. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1294\" active clinical trials using this agent." + }, + { + "input": "Concept: TROPONT (Protein measurement)", + "output": "Chemical procedure described as the determination of the amount of troponin T present in a blood sample." + }, + { + "input": "Concept: Labetalolum (Adrenergic alpha-Antagonists)", + "output": "something described as a third generation selective alpha-1-adrenergic antagonist and non-selective beta-adrenergic antagonist with vasodilatory and antihypertensive properties. Labetalol competitively binds to alpha-1-adrenergic receptors in vascular smooth muscle, thereby inhibiting the adrenergic stimulation of endothelial cell function and vasoconstriction in peripheral blood vessels. This agent also binds to beta-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in adrenergic stimulation. The result is a decrease in resting and exercise heart rates, cardiac output, and in both systolic and diastolic blood pressure, thereby resulting in vasodilation, and negative chronotropic and inotropic cardiac effects." + }, + { + "input": "Concept: alpha-2,8-sialosylhydrolase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids." + }, + { + "input": "Concept: Limiter Device (Manufactured Object)", + "output": "Manufactured Object described as an electronic device designed to prevent the amplitude of a wave from exceeding a set limit." + }, + { + "input": "Concept: Regimen Has Accepted Use For Disease (NCI Thesaurus Role)", + "output": "Conceptual Entity described as a role used to link established therapeutic regimens to their corresponding cancers or other diseases. Only established regimens published in NCI's Physician Data Query (PDQ), National Comprehensive Cancer Network (NCCN) Guidelines (http://www.nccn.org), or a limited number of other authoritative sources such as the Physician's Cancer Chemotherapy Manual are included. The domain and range for this role are 'Chemotherapy Regimen or Agent Combination' and 'Disease, Disorder or Finding', respectively." + }, + { + "input": "Concept: alkalinity (compounds by chemical function)", + "output": "Inorganic Chemicals described as in chemistry, a substance that can accept hydrogen ions in water and can neutralize an acid. Bases feel soapy or slippery on the skin and they can turn certain dyes blue. An example of a base is sodium hydroxide. Basicity is measured on a scale called the pH scale. On this scale, a pH value of 7 is neutral, and a pH value of more than 7 to 14 shows increasing basicity." + }, + { + "input": "Concept: CT scanogram of spine (Diagnostic Procedure)", + "output": "Diagnostic Procedure described as a radiographic technique used for showing true dimensions by moving a narrow orthogonal beam of x-rays along the length of the structure being measured." + }, + { + "input": "Concept: Frequency of Constipation (Clinical or Research Assessment Question)", + "output": "Clinical or Research Assessment Question described as a question about how often an individual has or had constipation." + }, + { + "input": "Concept: Grade 2 Esophageal ulcer (Esophageal Ulcer, CTCAE 5)", + "output": "Finding described as symptomatic; altered GI function; limiting instrumental ADL" + }, + { + "input": "Concept: mesonephric mesenchyme development (kidney mesenchyme development)", + "output": "kidney mesenchyme development described as the biological process whose specific outcome is the progression of a mesonephric mesenchyme from an initial condition to its mature state. This process begins with the formation of mesonephric mesenchyme and ends with the mature structure. Mesonephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the mesonephros." + }, + { + "input": "Concept: gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase activity (Molecular Function)", + "output": "something described as catalysis of the reaction: 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate." + }, + { + "input": "Concept: Appendiceal Carcinoma by AJCC v7 Stage (Carcinoma of the Appendix)", + "output": "Neoplastic Process described as a term that refers to the staging of appendiceal carcinoma according to the American Joint Committee on Cancer, 7th edition. Carcinoid tumors are staged separately." + }, + { + "input": "Concept: Hydrobromic acid (Acids, Noncarboxylic)", + "output": "generic drug products begining with the letter H described as hydrobromic acid (HBr). A solution of hydrogen bromide gas in water." + }, + { + "input": "Concept: GG-NER (Genetic Function)", + "output": "something described as the nucleotide-excision repair process in which DNA lesions are removed from nontranscribed strands and from transcriptionally silent regions over the entire genome." + }, + { + "input": "Concept: Abnormal brain choline/creatine ratio by MRS (Anatomical Abnormality)", + "output": "something described as a deviation from normal in the ratio of choline to creatine in the brain identified by magnetic resonance spectroscopy (MRS)." + }, + { + "input": "Concept: CSS05-Most Severe Idea, Frequency-Since (C-SSRS Already Enrolled Subjects Questionnaire Question)", + "output": "something described as columbia-Suicide Severity Rating Scale Already Enrolled Subjects - How many times have you had these thoughts? (Since Study Start)." + }, + { + "input": "Concept: PROPICILLIN (penicillins)", + "output": "Antibiotic described as a semisynthetic, acid stable, penicillin with antibacterial activity. Propicillin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis." + }, + { + "input": "Concept: Leukemias, Chronic B-Cell (cellular diagnosis, chronic lymphocytic leukemia)", + "output": "Neoplastic Process described as a chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease." + }, + { + "input": "Concept: downregulation of cardioblast differentiation (Cell Function)", + "output": "negative regulation of stem cell differentiation described as any process that stops, prevents, or reduces the frequency, rate or extent of cardioblast differentiation, the process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." + }, + { + "input": "Concept: Whipple's Disease (Infection caused by Tropheryma)", + "output": "disorder of jejunum and ileum described as an infection that is caused by the Gram-positive bacterium Tropheryma whipplei, which primarily affects the small intestine resulting in malabsorption." + }, + { + "input": "Concept: Cyclohexylamines (Cyclohexanes)", + "output": "Amines described as a family of alicyclic hydrocarbons containing an amine group with the general formula R-C6H10NH2." + }, + { + "input": "Concept: JAK 2 Protein Tyrosine Kinase (Proto-Oncogene Proteins)", + "output": "Proto-Oncogene Proteins described as a Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS." + }, + { + "input": "Concept: WD7D1 6 (WHODAS 2.0 36-item Version Self-administered Questionnaire Question)", + "output": "WHODAS 2.0 36-item Version Self-administered Questionnaire Question described as world Health Organization Disability Assessment Schedule 2.0 36-item Version Self-administered (WHODAS 2.0 36-item Version Self-administered) In the past 30 days, how much difficulty did you have in: Starting and maintaining a conversation?" + }, + { + "input": "Concept: JPS No. 3 node (Structure of left gastric lymph node)", + "output": "something described as left gastric lymph node located along the cardiac half of the lesser curvature of stomach in the lesser omentum." + }, + { + "input": "Concept: Grade 3 Neoplasms benign, malignant and unspecified (incl cysts and polyps) - Other, specify (Finding)", + "output": "Neoplasms Benign, Malignant and Unspecified (Incl Cysts and Polyps), CTCAE described as severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL" + }, + { + "input": "Concept: Mouse gp100 DNA Plasmid Vaccine (Immunologic Factor)", + "output": "something described as a vaccine consisting of a plasmid DNA encoding the murine melanoma-associated antigen gp100. Upon administration, expressed gp100 antigen may stimulate a cytotoxic T cell HLA-A2.1-restricted immune response against tumor cells that express the gp100 antigen, resulting in tumor cell lysis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C48410\" active clinical trials using this agent." + }, + { + "input": "Concept: Hip Surgery Distractors (Distractors, Surgical)", + "output": "Distractors, Surgical described as surgical distractors designed to apply traction force to a lower limb (leg) allowing access to the hip joint space. The distractor applies traction, allowing the surgeon to adjust the angle of abduction/adduction of the upper femur head in the pelvis acetabulum. These distractors typically consist of an adjustable mechanism that may include clamps, screws, levers, and a strap and/or other accessory attached to the leg; the mechanism is attached at the other end to the operating table (e.g., on a side rail) or other type of support. The mechanism is usually adjustable to different sizes of patients' legs. Hip distractors are intended for use during hip joint surgical procedures, such as arthroscopic surgery." + }, + { + "input": "Concept: Grade 2 Pancreatic Duct Stenosis, CTCAE (Pancreatic Duct Stenosis, CTCAE)", + "output": "Finding described as symptomatic; altered GI function" + }, + { + "input": "Concept: Procedure Kit/Trays, Catheterization, Intravenous, Central Vein (Medical Device)", + "output": "something described as prepackaged collections of the devices and supplies (either custom or standard) needed for the insertion of a catheter whose tip will reach the central venous system. The catheters are usually inserted into a large vein in the neck (internal or external jugular vein), chest (subclavian vein), or groin (femoral vein). Items in these kits may include gauge needles, sterile gloves, appropriate intravenous (IV) catheters, alcohol swabs, gauze pads, IV bags with solution, and tubing. The kits are frequently supplied in supporting trays (i.e., procedure trays) consisting of a flat-bottomed receptacle with a border around the periphery supporting all the instruments and supplies needed for the procedure; the trays are usually covered or wrapped. Central intravenous catheterization procedure kits and trays are intended for use during a variety of procedures, including the administration of fluids (e.g., medication, parenteral feeding), to perform central venous pressure measurements, and/or for other blood tests. They are used in hospitals (e.g., intensive and emergency care) and other healthcare facilities." + }, + { + "input": "Concept: Capsulotomies, Posterior (Surgical ocular refractive procedure)", + "output": "Surgical ocular refractive procedure described as procedures performed to remove CAPSULE OPACIFICATION that develops on the POSTERIOR CAPSULE OF THE LENS following removal of a primary CATARACT." + }, + { + "input": "Concept: Not Known if EGFR Mutation Analysis Was Performed (Finding)", + "output": "Finding described as an indication that it is not known whether EGFR mutation analysis was performed during the study." + }, + { + "input": "Concept: OC (Body Part, Organ, or Organ Component)", + "output": "something described as a subdivision of the occipital lobe of the macaque defined on the basis of cytoarchitecture. Identified with primary visual cortex, it \\\"stretches widely over the lateral aspect of the occipital lobe almost to the lunate sulcus of the macaque anteriorly and to the inferior occipital sulcus ventrally. \\\"On the medial surface it rapidly narrows as it passes forward and sinks into the depths of the calcarine sulcus. It is the \\\"most pronounced\\\" granulous cortex and relatively thin ( Bonin-1947 )." + }, + { + "input": "Concept: 3: 185762289-185782898 (Chromosome 3 Physical Location)", + "output": "something described as physical location of EPHB3_Gene" + }, + { + "input": "Concept: Ocimum sanctum L. (Ocimum)", + "output": "Ocimum described as a plant species of the genus OCIMUM, family LAMIACEAE that has been used in TRADITIONAL MEDICINE." + }, + { + "input": "Concept: Diversity, Antibody (Immunogenetics)", + "output": "Immune status described as the phenomenon of immense variability characteristic of ANTIBODIES. It enables the IMMUNE SYSTEM to react specifically against the essentially unlimited kinds of ANTIGENS it encounters. Antibody diversity is accounted for by three main theories: (1) the Germ Line Theory, which holds that each antibody-producing cell has genes coding for all possible antibody specificities, but expresses only the one stimulated by antigen; (2) the Somatic Mutation Theory, which holds that antibody-producing cells contain only a few genes, which produce antibody diversity by mutation; and (3) the Gene Rearrangement Theory, which holds that antibody diversity is generated by the rearrangement of IMMUNOGLOBULIN VARIABLE REGION gene segments during the differentiation of the ANTIBODY-PRODUCING CELLS." + }, + { + "input": "Concept: control of cell cycle progression (Mitotic Cell Cycle)", + "output": "something described as any process that modulates the rate or extent of progression through the cell cycle." + }, + { + "input": "Concept: Absent/small gallbladder (Finding)", + "output": "Abnormal gallbladder morphology described as absence or underdevelopment of the gallbladder." + }, + { + "input": "Concept: Sensitizations, Central (Chronic pain)", + "output": "Nervous System Physiological Phenomena described as intense stimulation or persistent injury can cause plasticity of the central nociceptive circuits, synaptic plasticity and increased neuronal responsiveness in central pain pathways after painful insults is known as central sensitisation." + }, + { + "input": "Concept: MICRO RNA 125B2 (Gene or Genome)", + "output": "Gene or Genome described as this gene is involved in the regulation of gene expression and plays a role in the development of hepatocellular carcinoma." + }, + { + "input": "Concept: Congenital disease of brain (Congenital neurological disorder)", + "output": "something described as pathologic condition existing at, and usually before, birth affecting the brain, which is composed of the intracranial components of the central nervous system." + }, + { + "input": "Concept: Woody tongue (Disease or Syndrome)", + "output": "Elevation of tongue described as woody tongue includes the involvement of the sublingual space causing elevation, posterior enlargement and protrusion of the tongue." + }, + { + "input": "Concept: 21: 38878739-38675671 (Spatial Concept)", + "output": "something described as physical location of ERG_Gene" + }, + { + "input": "Concept: Recurrent deep organ abscess formation (Severe infection)", + "output": "something described as repeated episodes of the formation of abscesses in organs. An abscess is a circumscribed area of pus or necrotic debris in the parenchyma or an organ. []" + }, + { + "input": "Concept: No (Finding)", + "output": "Finding described as an indication that the patient does not consume caffeine on a regular basis." + }, + { + "input": "Concept: Structure of precuneus (Parietal gyrus structure)", + "output": "Region of parietal cortex described as the posteromedial region of the parietal lobe bounded by the marginal branch of the cingulate sulcus anteriorly, by the medial portion of the parieto-occipital fissure posteriorly and by the subparietal sulcus inferiorly." + }, + { + "input": "Concept: Social security services (Social security services, systems and policies)", + "output": "Social security services, systems and policies described as services and programmes aimed at providing income support to people who, because of age, poverty, unemployment, health condition or disability, require public assistance that is funded either by general tax revenues or contributory schemes, such as services for determining eligibility, delivering or distributing assistance payments for the following types of programmes: social assistance programmes (e.g. non-contributory welfare, poverty or other needs-based compensation), social insurance programmes (e.g. contributory accident or unemployment insurance), and disability and related pension schemes (e.g. income replacement), including those who provide these services." + }, + { + "input": "Concept: TF (Body Part, Organ, or Organ Component)", + "output": "something described as an area on the ventral surface of the temporal lobe in the macaque that is defined on the basis of cytoarchitecture. It is located largely in the fusiform gyrus. Compared to area TE of Bonin the cortex is thinner, especially the internal pyramidal layer (V) and multiform layer (VI), and \\\"there is clearly visible... the characteristic which Economo gives for this region in man: 'the substratum Vb directly below has large cells... less densely arranged... so that Vb appears distinctly lighter... than the above stratum... Sometimes the cells in the upper layer Va are also less compactly arranged and this part of the stratum is then paler, which makes V show with a darker intermediate band between its upper and lower lighter rows'\\\" ( Bonin-1947 )." + }, + { + "input": "Concept: anxiety; episodic paroxysmal (Mental or Behavioral Dysfunction)", + "output": "something described as recurrent attacks of severe anxiety, whose occurence is not restricted to any particular situation or set of circumstances and is therefore unpredictable. []" + }, + { + "input": "Concept: phospholipase B activity (Molecular Function)", + "output": "carboxylic ester hydrolase activity described as catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate." + }, + { + "input": "Concept: HAQ-DI With VAS - Help From Another Person - Walking (Intellectual Product)", + "output": "Intellectual Product described as health Assessment Questionnaire Disability Index With Pain Visual Analog Scale (HAQ-DI With VAS) Categories usually need help from another person - Walking." + }, + { + "input": "Concept: MGC129761 (ABCA2 gene)", + "output": "Gene or Genome described as human ABCA2 wild-type allele is located in the vicinity of 9q34 and is approximately 22 kb in length. This allele, which encodes ATP-binding cassette sub-family A member 2 protein, may play a role in the mediation of cholesterol transport, and neural development." + }, + { + "input": "Concept: Squamous Carcinoma of the Rectum (Colorectal Squamous Cell Carcinoma)", + "output": "Carcinoma described as a rare epithelial tumour of the rectum, arising from squamous cells in the rectal epithelium, without the presence of squamous-lined fistulous tracts in the rectum or a proximal extension of squamous cell carcinoma of anal or gynaecological origin. The reported symptoms are often nonspecific, such as anorexia, weight loss, lower abdominal pain, rectal bleeding and changes of bowel habits." + }, + { + "input": "Concept: Decreased fumarate hydratase activity (Finding)", + "output": "something described as an abnormality of Krebs cycle metabolism that is characterized by a decreased rate of fumarate hydratase activity." + }, + { + "input": "Concept: sterol deacetylation (steroid deacetylation)", + "output": "steroid deacetylation described as the removal of an acetyl group from a sterol molecule. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." + }, + { + "input": "Concept: plasma membrane fusion (Membrane Fusion)", + "output": "Cell Function described as the joining of the lipid bilayer membrane that surround a cell with that of another cell, producing a single cell." + }, + { + "input": "Concept: Ambulation assistance (rnax ambulation actions)", + "output": "Therapeutic or Preventive Procedure described as actions performed to promote walking" + }, + { + "input": "Concept: Generalised gingivitis (Disease or Syndrome)", + "output": "Gingivitis described as gingivitis involving the entire mouth or more than 30 percent of the surfaces." + }, + { + "input": "Concept: LIP FISSURE (Disease or Syndrome)", + "output": "Lip Diseases described as a severe crack in a lip. A lip fissure may be painful, may bleed and often is a recurring manifestation. []" + }, + { + "input": "Concept: Injection of sclerosing agent (Therapeutic procedure)", + "output": "Sclerotherapy described as treatment of varicose veins, hemorrhoids, gastric and esophageal varices, and peptic ulcer hemorrhage by injection or infusion of chemical agents which cause localized thrombosis and eventual fibrosis and obliteration of the vessels." + }, + { + "input": "Concept: down-regulation of 17-methylnonadec-1-ene formation (negative regulation of 17-methylnonadec-1-ene metabolic process)", + "output": "Molecular Function described as any process that stops, prevents or reduces the frequency, rate or extent of 17-methylnonadec-1-ene biosynthetic process." + }, + { + "input": "Concept: Epithelium Part (Tissue Part)", + "output": "something described as any component of the avascular cellular layers that cover body surfaces and cavities and may form glands." + }, + { + "input": "Concept: OPHN1 Gene (Gene or Genome)", + "output": "Gene or Genome described as this gene plays a role in the mediation of GTP hydrolysis of Rho subfamily members." + }, + { + "input": "Concept: Sitalidone (Organic Chemical)", + "output": "Organic Chemical described as a benzenesulfonamide-based agent with salidiuretic and antihypertensive effects." + }, + { + "input": "Concept: right heart (Systemic venous system)", + "output": "Cardiac chamber structure described as region of heart which has as its parts the right atrium and right ventricle." + }, + { + "input": "Concept: Paclitaxel/Gemcitabine (Regimen Used to Treat Breast Carcinoma)", + "output": "Therapeutic or Preventive Procedure described as a chemotherapy regimen consisting of paclitaxel and gemcitabine used as a treatment for recurrent and metastatic breast cancer." + }, + { + "input": "Concept: Absent cremasteric reflex (Abnormal superficial reflex)", + "output": "Abnormal superficial reflex described as lack of response to scratching of the skin of the medial thigh, which in males normally elicits a brisk, short elevation of the ipsilateral testis, a phenomenon that is referred to as the cremaster reflex." + }, + { + "input": "Concept: university hospital (Manufactured Object)", + "output": "Health Care Related Organization described as hospitals maintained by a university for the teaching of medical students, postgraduate training programs, and clinical research." + }, + { + "input": "Concept: meso-tartrate dehydrogenase activity (oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)", + "output": "something described as catalysis of the reaction: (2R,3S)-tartrate + NAD(+) = dihydroxyfumarate + H(+) + NADH." + }, + { + "input": "Concept: Linolenic Acids (Fatty Acids, Essential)", + "output": "something described as eighteen-carbon essential fatty acids that contain three double bonds." + }, + { + "input": "Concept: 2-methylbut-2-enoyl-CoA(4-) metabolic process (fatty-acyl-CoA metabolic process)", + "output": "fatty-acyl-CoA metabolic process described as the chemical reactions and pathways involving 2-methylbut-2-enoyl-CoA(4-)." + }, + { + "input": "Concept: Substantia innominata (Limbic System)", + "output": "Limbic System described as tissue in the BASAL FOREBRAIN inferior to the anterior perforated substance, and anterior to the GLOBUS PALLIDUS and ansa lenticularis. It contains the BASAL NUCLEUS OF MEYNERT." + }, + { + "input": "Concept: UDP-N-acetylmuramyl-tripeptide synthetase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the reaction: meso-2,6-diaminopimelate + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Immunoassay, Rapid Test, Drug-of-Abuse, Opiate, Morphine (IVD Test Reagent/Kits, Immunoassay, Rapid Test, Drug-of-Abuse, Opiate)", + "output": "IVD Test Reagent/Kits, Immunoassay, Rapid Test, Drug-of-Abuse, Opiate described as immunoassay reagents intended to perform qualitative analyses on a body fluid sample (typically urine) to determine morphine levels in the sample within a short period of time, typically several minutes." + }, + { + "input": "Concept: Efalizumab-containing product (Selective immunosuppressants)", + "output": "Immunosuppressive Agents described as a monoclonal antibody used to treat psoriasis (a chronic skin disease). It is also being studied in the treatment of graft-versus-host disease (GVHD) of the skin after a donor stem cell transplant. Efalizumab binds to a molecule called LFA-1, and blocks the action of T cells (a type of white blood cell). It is a type of immunosuppressant." + }, + { + "input": "Concept: COPANLISIB HYDROCHLORIDE (Quinazolines)", + "output": "Phosphatidylinositide 3-Kinase Inhibitor described as the dihydrochloride salt form of copanlisib, a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Copanlisib hydrochloride inhibits the activation of the PI3K signaling pathway, which may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C138994\" active clinical trials using this agent." + }, + { + "input": "Concept: RNA VIGS (Genetic Function)", + "output": "something described as gene silencing induced by RNA viruses leading to a sequence-specific degradation of target mRNAs or post-transcriptional gene silencing." + }, + { + "input": "Concept: health family (Health Status)", + "output": "Finding described as overall health and social competence of a family" + }, + { + "input": "Concept: Date of visit (Finding)", + "output": "something described as the date on which a visit occurred." + }, + { + "input": "Concept: Vein of Galen Malformations (Congenital anomaly of central nervous system)", + "output": "Disorder of body cavity described as congenital arteriovenous malformation involving the VEIN OF GALEN, a large deep vein at the base of the brain. The rush of arterial blood directly into the vein of Galen, without passing through the CAPILLARIES, can overwhelm the heart and lead to CONGESTIVE HEART FAILURE." + }, + { + "input": "Concept: D-alpha-hydroxynitrile lyase activity (Molecular Function)", + "output": "something described as catalysis of the reaction: mandelonitrile = cyanide + benzaldehyde." + }, + { + "input": "Concept: Left ventricular hypertrophy (Disease or Syndrome)", + "output": "Myocardial disorders NEC described as enlargement or overgrowth of the myocardium of the left ventricle, due to chronic pressure overload." + }, + { + "input": "Concept: ATM Inhibitor M 3541 (Pharmacologic Substance)", + "output": "Serine/Threonine Kinase Inhibitor described as an orally bioavailable inhibitor of ataxia telangiectasia mutated kinase (ATM), with potential chemo-/radio-sensitizing and antineoplastic activities. Upon oral administration, M 3541 targets and binds to ATM, thereby inhibiting the kinase activity of ATM and ATM-mediated signaling. This prevents DNA damage checkpoint activation, disrupts DNA damage repair, induces tumor cell apoptosis, and leads to cell death of ATM-overexpressing tumor cells. In addition, M 3541 sensitizes tumor cells to chemo- and radiotherapy. ATM, a serine/threonine protein kinase, is upregulated in a variety of cancer cell types; it is activated in response to DNA damage and plays a key role in DNA-strand repair. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C138076\" active clinical trials using this agent." + }, + { + "input": "Concept: Refractory PVRL DLBCL (Refractory Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System)", + "output": "Primary Vitreoretinal Diffuse Large B-Cell Lymphoma described as primary vitreoretinal diffuse large B-cell lymphoma that does not respond to treatment." + }, + { + "input": "Concept: PDQUALIF - Social Life Not Affected (Intellectual Product)", + "output": "PDQUALIF Questionnaire Question described as parkinson's Disease Quality of Life Scale (PDQUALIF) My Parkinson's symptoms have not affected my social life." + }, + { + "input": "Concept: Alveolobasilar line (Fiat anatomical line of head)", + "output": "Body Location or Region described as fiat anatomical line of head, each instance of which is a line from some basion to some upper alveolar limit." + }, + { + "input": "Concept: modulation of programmed cell death in other organism (regulation of programmed cell death)", + "output": "modulation of process of other organism described as a process in which an organism modulates the frequency, rate or extent of programmed cell death in a second organism." + }, + { + "input": "Concept: gastric cancer, recurrent (Stomach Carcinoma)", + "output": "Stomach Carcinoma described as the reemergence of gastric carcinoma after a period of remission." + }, + { + "input": "Concept: Skeletal muscles, NOS (Skeletal muscle and/or tendon structure)", + "output": "Structure of striated muscle described as voluntary, striated muscle tissue predominantly associated with the skeleton." + }, + { + "input": "Concept: Have Trouble Controlling Urine (Intellectual Product)", + "output": "Clinical or Research Assessment Question described as a question about whether an individual has or had trouble controlling their urine." + }, + { + "input": "Concept: CDISC ADAS-Cog - Word Recognition Trial 1 Summary Score (Intellectual Product)", + "output": "Intellectual Product described as alzheimer's Disease Assessment Scale-Cognitive CDISC Version - Sub-score for word recognition trial 1." + }, + { + "input": "Concept: Perinephric (Body part)", + "output": "Peri-location described as surrounding the kidney in whole or in part." + }, + { + "input": "Concept: SULFOLOBUS VIRUS 001 (Fusellovirus)", + "output": "something described as species in the genus Fusellovirus." + }, + { + "input": "Concept: Test tube rack (biomedical tube device)", + "output": "biomedical tube device described as racks designed for holding test tubes during the performance of a laboratory procedure. These racks typically consist of a metal, wooden, and/or plastic framework with holes across it to slide the test tubes and hold them in place. Racks used for culture procedures are usually intended to hold the test tubes in a nearly horizontal position in order to maximize the surface of the culture medium inside the tubes. Test tube racks are mainly used in clinical laboratories (e.g., to perform cultures), surgery centers, and research laboratories." + }, + { + "input": "Concept: Hyperflexion injury (Injury or Poisoning)", + "output": "Injury or Poisoning described as injury to a joint due to flexion of a joint beyond its normal range of movement." + }, + { + "input": "Concept: K(VCA)Alpha (Amino Acid, Peptide, or Protein)", + "output": "Ion Channel Protein described as calcium-activated potassium channel subunit alpha-1 (1236 aa, ~138 kDa) is encoded by the human KCNMA1 gene. This protein plays a role in calcium-dependent potassium transport." + }, + { + "input": "Concept: hyperviscosity (Raised hematology finding)", + "output": "something described as an increase in the viscosity of blood resulting from an increase in the proportion of cellular elements of the blood, a change in the mechanical properties of the cellular elements of the blood, and/or an alteration in plasma viscosity." + }, + { + "input": "Concept: CD45 antigen, human (Amino Acid, Peptide, or Protein)", + "output": "PTPRC Gene Product described as receptor-type tyrosine-protein phosphatase C (1304 aa, ~147 kDa) is encoded by the human PTPRC gene. This protein plays a role in protein dephosphorylation." + }, + { + "input": "Concept: NHL, stage II adult (Adult Non-Hodgkin's Lymphoma Stage)", + "output": "something described as stage II is divided into stages II and IIE. In stage II, cancer is found in two or more lymph node groups, and both are either above or below the diaphragm (the thin muscle below the lungs that helps breathing and separates the chest from the abdomen). In stage IIE, cancer is found in one or more lymph node groups either above or below the diaphragm and outside the lymph nodes in an organ or area on the same side of the diaphragm as the lymph nodes with cancer." + }, + { + "input": "Concept: Grade 3 Enterocolitis (Finding)", + "output": "something described as severe or persistent abdominal pain; fever; ileus; peritoneal signs" + }, + { + "input": "Concept: Gabapentin-containing product (Other antiepileptics in ATC)", + "output": "Amines described as cyclohexananeacetic acid originally used as an anticonvulsant, found to have diverse CNS depressant actions." + }, + { + "input": "Concept: Defect, Congenital Heart (Congenital Abnormality)", + "output": "Congenital anomaly of cardiovascular system described as imperfections or malformations of the heart, existing at birth" + }, + { + "input": "Concept: Emergency Medical Dispatch (Emergency medical service)", + "output": "Emergency medical service described as the mobilization of EMERGENCY CARE to the locations and people that need them." + }, + { + "input": "Concept: serotonin secretion by mast cell (Intracellular Transport)", + "output": "exocytic process described as the regulated release of serotonin by a mast cell or group of mast cells." + }, + { + "input": "Concept: Building and Grounds Clearing and Maintenance (Occupation or Discipline)", + "output": "something described as a class of professional or vocational positions of employment that involve building and grounds clearing or maintenance." + }, + { + "input": "Concept: Lipoma of Tonsil (Neoplastic Process)", + "output": "Lipoma described as a benign adipose tissue neoplasm of the tonsils." + }, + { + "input": "Concept: Chicken Monocytic Leukemia (Chicken Neoplasm)", + "output": "Neoplastic Process described as monocytic leukemia that occurs in a chicken." + }, + { + "input": "Concept: PGP gene (Phosphatase Family Gene)", + "output": "Gene or Genome described as this gene may be involved in regulating oxygen transport." + }, + { + "input": "Concept: Oral route (Digestive tract route)", + "output": "something described as taking a medicinal product by means of swallowing." + }, + { + "input": "Concept: FC, RHODAMINE, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)", + "output": "something described as an immunoglobulin G (Fc fragment specific) immunological test system is a device that consists of the reagents used to measure by immunochemical techniques the Fc (carbohydrate containing) fragment of immunoglobulin G (resulting from breakdown of immunoglobulin G antibodies) in urine, serum, and other body fluids. Measurement of immunoglobulin G Fc fragments aids in the diagnosis of plasma cell antibody-forming abnormalities, e.g., gamma heavy chain disease." + }, + { + "input": "Concept: Patient Simulation (Educational Activity)", + "output": "Educational process of instructing described as the use of persons coached to feign symptoms or conditions of real diseases in a life-like manner in order to teach or evaluate medical personnel." + }, + { + "input": "Concept: Clumping of elastic fibers in the dermis (Finding)", + "output": "something described as formation of clumps or aggregates that make up small protuberances from elastic fibers within the dermis (especially the reticular dermis)." + }, + { + "input": "Concept: How much DIFFICULTY do you currently have reading and following complex instructions (Clinical or Research Assessment Question)", + "output": "Intellectual Product described as a question about how much difficulty an individual currently has reading and following complex instructions." + }, + { + "input": "Concept: Muscle hypertrophy (Organ or Tissue Function)", + "output": "striated muscle hypertrophy described as the enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." + }, + { + "input": "Concept: Circulatory shock (Pathologic Processes)", + "output": "Cardiovascular Diseases described as a profound hemodynamic and metabolic disturbance characterized by the failure of the circulatory system to maintain adequate perfusion of vital organs; causes inadequate delivery of nutrients and insufficient removal of cellular waste products to and from the tissues." + }, + { + "input": "Concept: HK binding (kininogen binding)", + "output": "Molecular Function described as interacting selectively and non-covalently with a kininogen of high molecular mass." + }, + { + "input": "Concept: BEBQ Retrospective Version - Got Full Before Taking All Milk (Intellectual Product)", + "output": "BEBQ Retrospective Version Questionnaire Question described as baby Eating Behaviour Questionnaire - Retrospective - My baby got full before taking all the milk I think he/she should have." + }, + { + "input": "Concept: Geneticists (Professional or Occupational Group)", + "output": "something described as a scientist who studies or works in genetics." + }, + { + "input": "Concept: Have you, during the past week, been bothered by tension (Intellectual Product)", + "output": "something described as a question about whether an individual is or was bothered by tension." + }, + { + "input": "Concept: Lissauer's tract (Fasciculus of spinal cord)", + "output": "White matter of medulla oblongata described as fasciculus of spinal cord, each instance of which is a group of nerve fibers in the lateral funiculus of some spinal cord immediately external to the posterior horn, composed in part of primary pain and temperature fibers which enter some spinal cord, travel the distance of a few segments in the dorsolateral tract, and then synapse in the posterior horn." + }, + { + "input": "Concept: MDS-UPDRS - Postural Tremor of Left Hand (MDS-UPDRS Questionnaire Question)", + "output": "something described as the Movement Disorder Society version of the Unified Parkinson's Disease Rating Scale - Postural Tremor of the Left Hand." + }, + { + "input": "Concept: production of siRNA involved in chromatin silencing by small RNA (Genetic Function)", + "output": "Genetic Function described as cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of chromatin silencing by small RNA." + }, + { + "input": "Concept: Explosive Agents (Chemical Viewed Functionally)", + "output": "Specialty Uses of Chemicals described as substances that are energetically unstable and can produce a sudden expansion of the material, called an explosion, which is accompanied by heat, pressure and noise. Other things which have been described as explosive that are not included here are explosive action of laser heating, human performance, sudden epidemiological outbreaks, or fast cell growth." + }, + { + "input": "Concept: Grade 4 Ileal obstruction (Finding)", + "output": "Finding described as life-threatening consequences; urgent operative intervention indicated" + }, + { + "input": "Concept: Navy Bean Powder (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as the powder form of the cooked navy bean with potential antioxidant and chemopreventive activities. Navy beans are rich in fiber, minerals, vitamins, and phytochemicals such as flavonoids and phytosterols. They appear to prevent carcinogenesis by inducing tumor cell apoptosis. Intake of navy bean powder may have a beneficial effect on intestinal microflora. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C111687\" active clinical trials using this agent." + }, + { + "input": "Concept: Buffalo rat (Rattus norvegicus)", + "output": "Mammal described as derived from Buffalo stock of H. Morris to the NIH in 1950 and disseminated from Charles River since 1998, the Buffalo is a white albino rat, genotype c. The incidence of spontaneous tumor formation includes anterior pituitary and adrenal cortex in upwards of 30% of aged rats. The Buffalo rat is used most commonly in oncology and carcinogenesis research. Low incidence of dental caries. Spontaneous tumors of anterior pituitary 30%, and of adrenal cortex 25% in older animals. Survival 58% at 2 years of age with thyroid carcinoma in 25% (Lindsey et al 1968). Low incidence of renal neoplasms (Snell 1967). High incidence of tumors of the anterior pituitary, adrenal medulla and adrenal cortex in animals over 18 months old (Snell1965)." + }, + { + "input": "Concept: downregulation of acrosome reaction (Cell Function)", + "output": "negative regulation of fertilization described as any process that stops, prevents or reduces the frequency, rate or extent of acrosome reaction." + }, + { + "input": "Concept: PSA Level Between Zero and Two (PSA Level Finding)", + "output": "something described as a blood concentration of prostate specific antigen between 0 ng/mL and 2 ng/mL." + }, + { + "input": "Concept: ACANTRBC (Blood Cell Count Ratio Measurement)", + "output": "something described as a relative measurement (ratio or percentage) of acanthocytes to all erythrocytes in a biological specimen." + }, + { + "input": "Concept: Assess bereavement support (Procedure with a procedure focus)", + "output": "something described as assessing a patient's family and/or friends need for bereavement support after the patient's death." + }, + { + "input": "Concept: purine nucleoside monophosphate catabolic process (Molecular Function)", + "output": "Molecular Function described as the chemical reactions and pathways resulting in the breakdown of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." + }, + { + "input": "Concept: innate vocalization behavior (Individual Behavior)", + "output": "Individual Behavior described as a vocalisation behavior that is innate, i.e. that does not need to be learned in order to occur." + }, + { + "input": "Concept: Cochlear structure (Cochlear structure)", + "output": "Membranous labyrinth structure described as subdivision of bony labyrinth, each instance of which is a spiral structure of of some bony labyrinth, the cavity of which contains the organ of Corti." + }, + { + "input": "Concept: Rete Testis (Seminiferous tubule structure)", + "output": "something described as a network of tubules that convey sperm from the seminiferous tubules within the testicles to the efferent ducts." + }, + { + "input": "Concept: Sclerosis of the middle phalanx of the 3rd toe (Anatomical Abnormality)", + "output": "something described as an elevation in bone density in the middle phalanx of the third toe. Sclerosis is normally detected on a radiograph as an area of increased opacity." + }, + { + "input": "Concept: I feel that my physician has provided me choices and options (Clinical or Research Assessment Question)", + "output": "Clinical or Research Assessment Question described as a question about whether an individual feels that their physician has provided choices and options." + }, + { + "input": "Concept: Trans fat modified diet (Fat modified diet)", + "output": "something described as increase or decrease in trans fat content of the diet." + }, + { + "input": "Concept: DISTAL COMMON BILE DUCT (Anatomical Structure)", + "output": "Common bile duct structure described as the section of the tube-like structure carrying bile that is closest to the intestine and furthest from the hepatic and cystic ducts." + }, + { + "input": "Concept: ent-cassadiene C11alpha-hydroxylase activity (Molecular Function)", + "output": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen described as catalysis of the reaction: ent-cassa-12,15-diene + O2 + NADPH + H+ = ent-11beta-hydroxycassa-12,15-diene + NADP+ + H2O." + }, + { + "input": "Concept: Sanicula L., 1753 (Plant)", + "output": "Saniculeae described as a plant genus of the family Apiaceae. Commonly called snakeroot but that name is used for many other plants such as ASARUM; ARISTOLOCHIA; and Polygala." + }, + { + "input": "Concept: status migrainosus (Disorder of soft tissue of body cavity)", + "output": "Cerebrovascular and spinal vascular disorders NEC described as an episode of migraine that persists for more than 72 hours." + }, + { + "input": "Concept: Indirect (General Qualifier)", + "output": "Relationships described as not as a direct effect or consequence; having intervening factors or persons or influences." + }, + { + "input": "Concept: INFANT PREMATURE DIS (Disease or Syndrome)", + "output": "something described as diseases that occur in PREMATURE INFANTS." + }, + { + "input": "Concept: Tables, Imaging, Radiographic (Tables, Imaging)", + "output": "Medical Device described as a radiologic table is a device intended for medical purposes to support a patient during radiologic procedures. The table may be fixed or tilting and may be electrically powered." + }, + { + "input": "Concept: Use Before Visit (Finding)", + "output": "Finding described as an indication that an individual used something prior to their baseline visit." + }, + { + "input": "Concept: deficiency vitamin k (Blood Coagulation Disorders)", + "output": "Vitamin related disorders described as deficiency of vitamin K. It may lead to bleeding, manifested with ecchymoses, petechiae, and hematomas. In infants it may cause hemorrhagic disease of newborn with intracranial and retroperitoneal bleeding." + }, + { + "input": "Concept: septum secundum development (atrial septum development)", + "output": "Organ or Tissue Function described as the progression of the septum secundum over time, from its initial formation to the mature structure." + }, + { + "input": "Concept: CURETTE, SURGICAL, GENERAL USE (Medical Device)", + "output": "Medical Device described as a manual surgical instrument for general use is a nonpowered, hand-held, or hand-manipulated device, either reusable or disposable, intended to be used in various general surgical procedures. The device includes the applicator, clip applier, biopsy brush, manual dermabrasion brush, scrub brush, cannula, ligature carrier, chisel, clamp, contractor, curette, cutter, dissector, elevator, skin graft expander, file, forceps, gouge, instrument guide, needle guide, hammer, hemostat, amputation hook, ligature passing and knot-tying instrument, knife, blood lancet, mallet, disposable or reusable aspiration and injection needle, disposable or reusable suturing needle, osteotome, pliers, rasp, retainer, retractor, saw, scalpel blade, scalpel handle, one-piece scalpel, snare, spatula, stapler, disposable or reusable stripper, stylet, suturing apparatus for the stomach and intestine, measuring tape, and calipers. A surgical instrument that has specialized uses in a specific medical specialty is classified in separate regulations in Parts 868 through 892." + }, + { + "input": "Concept: elongin complex location (transcription elongation factor complex)", + "output": "transcription elongation factor complex described as a transcription elongation factor complex that suppresses RNA polymerase II pausing, and may act by promoting proper alignment of the 3'-end of nascent transcripts with the polymerase catalytic site. Consists of a transcriptionally active Elongin A subunit (about 100 kDa) and two smaller Elongin B (about 18 kDa) and Elongin C (about 15 kDa) subunits." + }, + { + "input": "Concept: Lid2 complex (protein-containing complex)", + "output": "Cell Component described as a protein complex that is thought to be involved in regulation of chromatin remodeling. In Schizosaccharomyces the complex contains Lid1p, Ash2p, Ecm5p, Snt2p, and Sdc1p." + }, + { + "input": "Concept: Flytraps (Plant)", + "output": "Plant described as a genus of carnivorous plants." + }, + { + "input": "Concept: EPIC104D (EPIC-26 Questionnaire Question)", + "output": "EPIC-26 Questionnaire Question described as the Expanded Prostate Cancer Index Composite Short Form (EPIC-26) How big a problem, if any, has each of the following been for you during the last 4 weeks? Weak urine stream or incomplete emptying." + }, + { + "input": "Concept: occlusion by organism of vascular system in other organism involved in symbiotic interaction (Biologic Function)", + "output": "modification of structure of other organism involved in symbiotic interaction described as the process in which an organism reduces the flow of fluid within its second organism's vascular system, the vessels and tissue that carry or circulate fluids, such as blood, lymph or sap, through the body of an animal or plant, where the two organisms are in a symbiotic interaction." + }, + { + "input": "Concept: MGA, TYPE II (Syndrome)", + "output": "Congenital Heart Defects described as rare congenital X-linked disorder of lipid metabolism. Barth syndrome is transmitted in an X-linked recessive pattern. The syndrome is characterized by muscular weakness, growth retardation, DILATED CARDIOMYOPATHY, variable NEUTROPENIA, 3-methylglutaconic aciduria (type II) and decreases in mitochondrial CARDIOLIPIN level. Other biochemical and morphological mitochondrial abnormalities also exist." + }, + { + "input": "Concept: Grade 2 Pulmonary Valve Disease, CTCAE (Pulmonary Valve Disease, CTCAE)", + "output": "Pulmonary Valve Disease, CTCAE described as asymptomatic; moderate regurgitation or stenosis by imaging" + }, + { + "input": "Concept: phosphatidylcholine desaturase activity (Molecular Function)", + "output": "oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor described as catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + NAD(+) = 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + H(+) + NADH." + }, + { + "input": "Concept: Previous and Current Therapy (Therapeutic or Preventive Procedure)", + "output": "something described as the name of any therapy that was previously and/or is currently being administered." + }, + { + "input": "Concept: growth retardation-ocular abnormalities-microcephaly-brachydactyly-oligophrenia (GOMBO) syndrome (Disease or Syndrome)", + "output": "something described as a syndrome of severe microcephaly, microphthalmia, prominent nose, mandibular overgrowth, dental anomalies, brachydactyly with clinodactyly V, delayed growth and puberty, abnormal dermatoglyphics, premature aging of the skin, and severe mental retardation. There are indications in later findings that Myhre and GOMBO syndromes are the same entity" + }, + { + "input": "Concept: Cyst, Tarlov (Nerve root and plexus disorders)", + "output": "Peripheral nerve finding described as a cerebrospinal fluid-filled nerve root cyst most often localized in the sacral spine." + }, + { + "input": "Concept: recurrent childhood anaplastic oligoastrocytoma (Recurrent Childhood Central Nervous System Neoplasm)", + "output": "Childhood Anaplastic Oligoastrocytoma described as the reemergence of anaplastic oligoastrocytoma in childhood after a period of remission." + }, + { + "input": "Concept: PHQ Screener Version - Anxiety Attack Choking (Intellectual Product)", + "output": "Intellectual Product described as patient Health Questionnaire Screener Version - Think about your last bad anxiety attack. Did you feel as if you were choking?" + }, + { + "input": "Concept: Phototherapy unit (Medical Device)", + "output": "Electromechanical Devices described as equipment designed to irradiate patients with light to produce beneficial bioeffects (i.e., phototherapy). These devices are intended to apply electromagnetic radiation of all or some part of the spectrum covering the near infrared (from 700 to 1,400 nm), visible (from 380 to 780 nm), and/or ultraviolet (typically from 170 to 400 nm) spectrum. Most of this equipment is specialized for some particular application, such as treatment of hyperbilirubinemia (jaundice) in newborns, warming newborns and physiotherapy using infrared lights, and dermal treatments (e.g., psoriasis) using ultraviolet light." + }, + { + "input": "Concept: PedsQL Neuromuscular Module Version 3.0 Parent Report for Teen - Hard to Use Hands (Intellectual Product)", + "output": "something described as pediatric Quality of Life Neuromuscular Module Version 3 Teen Parent Report - In the past one month, how much of a problem has this been for your teen: It is hard for my child to use his or her hands." + }, + { + "input": "Concept: Obstruction of duodenum (Other diseases of stomach and duodenum)", + "output": "Duodenal Diseases described as hindrance of the passage of luminal contents in the DUODENUM. Duodenal obstruction can be partial or complete, and caused by intrinsic or extrinsic factors. Simple obstruction is associated with diminished or stopped flow of luminal contents. Strangulating obstruction is associated with impaired blood flow to the duodenum in addition to obstructed flow of luminal contents." + }, + { + "input": "Concept: Immunogenicity Specimen Assessments Original Result (Finding)", + "output": "something described as the outcome of the immunogenicity specimen assessment as originally received or collected." + }, + { + "input": "Concept: collagen type i (Proteins)", + "output": "Collagen fiber of periodontium described as a heterotrimeric fibrillar protein complex comprised of two collagen alpha-1(I) chains and one collagen alpha-2(I) chains. Type I collagen is the most abundant fibrillar collagen in humans and is present in scar tissue, tendons, ligaments, bone, dermis, dentin, and organ capsules." + }, + { + "input": "Concept: Loss of Function Mutation (Genetic Function)", + "output": "something described as a mutation that causes a decrease in or elimination of a gene product's activity." + }, + { + "input": "Concept: Sertoli cell development (Cell Function)", + "output": "epithelial cell development described as the process whose specific outcome is the progression of a Sertoli cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a Sertoli cell fate." + }, + { + "input": "Concept: Fasting (Diet)", + "output": "Intake Regulation, Food described as abstaining from FOOD." + }, + { + "input": "Concept: down regulation of coenzyme F420-dependent nitroimidazole breakdown (negative regulation of nitrogen compound metabolic process)", + "output": "Molecular Function described as any process that stops, prevents or reduces the frequency, rate or extent of coenzyme F420-dependent bicyclic nitroimidazole catabolic process." + }, + { + "input": "Concept: Rectal Route of Drug Administration (Administration, Mucosal)", + "output": "route of administration by method or body site described as an intracolonic route that begins in the rectum." + }, + { + "input": "Concept: Chest Pain - Cardiac (Cardiac Disorders, CTCAE)", + "output": "Finding described as a disorder characterized by substernal discomfort due to insufficient myocardial oxygenation e.g., angina pectoris." + }, + { + "input": "Concept: URINE (Urinary tract fluid)", + "output": "something described as excretion in liquid state processed by the kidney." + }, + { + "input": "Concept: Falx (Body Part, Organ, or Organ Component)", + "output": "Brain part described as a double-fold of dura mater that lies within the medial longitudinal fissure, and which separates the two cerebral hemispheres. It is attached rostrally to the crista galli and caudally to the surface of the tentorium cerebelli." + }, + { + "input": "Concept: Protoplasms (Brush cell)", + "output": "Pancreatic ductal cell described as the organized colloidal complex of organic and inorganic substances (as proteins and water) that constitutes the living nucleus, cytoplasm, plastids, and mitochondria of the cell. It is composed mainly of nucleic acids, proteins, lipids, carbohydrates, and inorganic salts." + }, + { + "input": "Concept: Triangular epiphysis of the distal phalanx of the 2nd finger (Triangular epiphyses of the distal phalanges of the hand)", + "output": "something described as a triangular appearance of the epiphysis of the distal phalanx of the 2nd finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat." + }, + { + "input": "Concept: 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (Pharmacologic Substance)", + "output": "Porphyrin and porphyrin derivative described as a synthetic light-activated chlorin with photodynamic activity. Upon systemic administration, temoporfin distributes throughout the body and is taken up by tumor cells. Upon stimulation of temoporfin by non-thermal laser light (at 652 nm), and in the presence of oxygen, this agent produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to tumor cells. This may kill tumor cells and may reduce the tumor size. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1669\" active clinical trials using this agent." + }, + { + "input": "Concept: pyrogallol 1,2-dioxygenase activity (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)", + "output": "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen described as catalysis of the reaction: O(2) + pyrogallol = (Z)-5-oxohex-2-enedioate + 2 H(+)." + }, + { + "input": "Concept: Frankincense (Boswellia)", + "output": "Boswellia described as a tree that belongs to the incense tree family. The tree's amber-colored resin is used in incense. The resin has anti-inflammatory effects and has been used to treat arthritis, asthma, and ulcerative colitis. It is also being studied in the treatment of brain tumors." + }, + { + "input": "Concept: C-SSRS Screening - Description of Aborted Suicide Attempt (Intellectual Product)", + "output": "C-SSRS Screening Questionnaire Question described as columbia-Suicidality Severity Rating Scale Screening (C-SSRS Screening) Description of aborted attempt." + }, + { + "input": "Concept: Abnormal fucosylation of O-linked protein glycosylation (Abnormal protein O-linked glycosylation)", + "output": "Finding described as an anomaly of the addition of fucose sugar units to O-linked glycans." + }, + { + "input": "Concept: DRRI-2 - L: Losing My Civilian Job (DRRI-2 Questionnaire Question)", + "output": "DRRI-2 Questionnaire Question described as deployment Risk & Resilience Inventory-2 - During deployment, I was concerned about: losing my civilian job because of the deployment." + }, + { + "input": "Concept: P10s-PADRE Vaccine (Cancer Vaccines)", + "output": "Amino Acid, Peptide, or Protein described as a peptide-based vaccine containing a carbohydrate mimetic peptide (CMP) P10s fused to the pan HLA DR-binding epitope (PADRE) peptide, with immunomoadjuvant activity and potential antineoplastic activity. Upon injection of the mimotope-P10s-PADRE peptide vaccine, the P10s peptide, which mimics gangliosides and other tumor-associated carbohydrate antigens (TACA), both stimulates a cytotoxic T-lymphocyte (CTL) response towards cells expressing TACAs and induces the production of antibodies that are reactive with a broad set of TACAs. Additionally, the anti-TACA antibodies may interfere with cellular pathways involved in tumor cell survival and may induce antibody-dependent cellular cytotoxicity (ADCC) toward cells expressing TACAs. PADRE is a helper T-cell epitope that is able to increase the magnitude and duration of the CTL response. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C123381\" active clinical trials using this agent." + }, + { + "input": "Concept: C-SSRS Lifetime/Recent Version - Reasons for Most Severe Ideation (Intellectual Product)", + "output": "something described as columbia-Suicide Severity Rating Scale Lifetime/Recent Version - What sort of reasons did you have for thinking about wanting to die or killing yourself? Was it to end the pain or stop the way you were feeling (in other words you couldn't go on living with this pain or how you were feeling) or was it to get attention, revenge or a reaction from others? Or both? (Past 1 Month)." + }, + { + "input": "Concept: Analyzers, Laboratory, Immunoassay, Photometric (Analyzers, Laboratory, Immunoassay)", + "output": "something described as immunoassay analyzers that use a dedication filter photometer or spectrophotometer as a detection system. These analyzers usually include an autosampler, a reagent dispenser, a washer, a filter photometer or spectrophotometer as a detector, and, typically, computerized data processing devices. Photometric immunoassay analyzers can be used to monitor immunoassays that produce compounds that absorb monochromatic light." + }, + { + "input": "Concept: CTPIND (Indicator)", + "output": "something described as an indication as to whether there is a prolapsed cardiac valve chordae tendineae." + }, + { + "input": "Concept: Confidence Score 5 (Intellectual Product)", + "output": "Intellectual Product described as a subjective score of 5 on a confidence scale that ranges from 1: Not at all confident to 7: Extremely confident." + }, + { + "input": "Concept: Stratum medullare profundum colliculi superioris (Corpora quadrigemina, superior colliculus)", + "output": "something described as the deepest layer of the seven-layered superior colliculus in primates and rodents. Identified by internal structure, it is located between the deep gray layer of the superior colliculus and the periaqueductal gray ( Carpenter-1983 ). Functionally it is one of four middle and deep layers that constitute the motor superior colliculus in the subcortical motor system ( Swanson-2004 ).\\r\\n" + }, + { + "input": "Concept: SRB8/9/10/11 complex (nuclear cyclin-dependent protein kinase holoenzyme complex location)", + "output": "nuclear cyclin-dependent protein kinase holoenzyme complex location described as cyclin-dependent kinase complex which reversibly associates with the Mediator complex. In Saccharomyces cerevisiae it consists of SSN2, SSN3, SSN8 and SRB8." + }, + { + "input": "Concept: Neuronophagia (Cell or Molecular Dysfunction)", + "output": "Nervous system disorders NEC described as the phagocytic destruction of nerve cells." + }, + { + "input": "Concept: Esophagus and Esophagogastric Junction Cancer pT3 TNM Finding v8 (Esophagus and Esophagogastric Junction Cancer Pathologic Primary Tumor TNM Finding v8)", + "output": "Finding described as esophagus and esophagogastric junction cancer with tumor invading adventitia." + }, + { + "input": "Concept: Wound opened up (Pathologic Function)", + "output": "Spatial Displacement described as separation of the layers of a surgical wound; it may be partial and superficial only, or complete with disruption of all layers." + }, + { + "input": "Concept: N2 Sleep/Total Sleep Time (Polysomnography)", + "output": "Laboratory Procedure described as the determination of the ratio of N2 sleep time compared to total sleep time. The measurement may be expressed as a ratio or percentage." + }, + { + "input": "Concept: Verbal Meaning (Qualitative Concept)", + "output": "Qualitative Concept described as connotative or denotative meaning associated with any verbally informative unit (e.g., morpheme, word, sentence, or phrase)." + }, + { + "input": "Concept: Homozygotes (GENE-RELATED PHENOMENA)", + "output": "Genetic finding described as an individual or cell characterized by having identical alleles at one or more loci in homologous chromosome segments." + }, + { + "input": "Concept: anti-CD38 monoclonal antibody MOR03087 (Anti-CD38 Monoclonal Antibody)", + "output": "Pharmacologic Substance described as a fully human monoclonal antibody directed against the cell surface glycoprotein CD-38 with potential antineoplastic activity. Anti-CD38 monoclonal antibody MOR03087 specifically binds to CD38 on CD38-positive tumor cells. This may trigger antitumoral antibody-dependent cellular cytotoxicity (ADCC) and may eventually lead to cell lysis in CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies, and its expression has been correlated with poor prognosis." + }, + { + "input": "Concept: C-SSRS Children's Since Last Visit - Self-injurious Behavior, Intent Unknown (Intellectual Product)", + "output": "something described as columbia-Suicidality Severity Rating Scale Children's Since Last Visit (C-SSRS Children's Since Last Visit) Has subject engaged in self-injurious behavior, intent unknown?" + }, + { + "input": "Concept: Terminal Nucleotidyltransferase 4B (Amino Acid, Peptide, or Protein)", + "output": "Enzyme described as terminal nucleotidyltransferase 4B (572 aa, ~63 kDa) is encoded by the human TENT4B gene. This protein is involved in mRNA quality control processes." + }, + { + "input": "Concept: pyrenes (Hazardous or Poisonous Substance)", + "output": "Organic Chemical described as polycyclic hydrocarbon, C16H10." + }, + { + "input": "Concept: ukat/10^12{RBC} (Unit of Catalytic Activity)", + "output": "something described as unit of catalytic activity concentration defined as activity equal to one millionth of katal per 10^12 erythrocytes." + }, + { + "input": "Concept: Easily fatigued (MUSCLE SOFT, TISSUE)", + "output": "MUSCLE SOFT, TISSUE described as a question about whether an individual is or was easily fatigued." + }, + { + "input": "Concept: superficial soft tissue fibrosis (Fibrosis)", + "output": "Disease or Syndrome described as fibrotic degeneration of the superficial soft tissues." + }, + { + "input": "Concept: Pincer Biopsy Guns (Medical Device)", + "output": "Medical Device described as single-use end-cut biopsy guns designed for the automatic extraction of core tissue samples (typically in the form of a cylinder) from an anatomic structure of the body. End-cut disposable biopsy guns typically consist of a single-use, spring-loaded mechanism that advances the inner disposable biopsy needles, which work like a pair of pincers, cutting off the sample and retracting it in the cannula without suction. Biopsy guns are used mainly to obtain samples of soft tissue from internal organs, including the kidneys, prostate, pancreas, and liver and the breast. The procedures are frequently performed under image guidance (e.g., radiographic, ultrasonic, magnetic resonance)." + }, + { + "input": "Concept: metanephric smooth muscle tissue development (Organ or Tissue Function)", + "output": "Organ or Tissue Function described as the process whose specific outcome is the progression of smooth muscle in the metanephros over time, from its formation to the mature structure." + }, + { + "input": "Concept: madurella (Sordariales incertae sedis)", + "output": "Sordariales described as a mitosporic fungal genus that causes MYCETOMA in humans. Madurella grisea and M. mycetomatis are the etiological agents." + }, + { + "input": "Concept: SPINAL CORD, SACRAL (Sacral spinal cord structure)", + "output": "Body Part, Organ, or Organ Component described as the segment of the spinal cord between the lumbar spinal cord and the caudal spinal cord." + }, + { + "input": "Concept: boss receptor activity (Molecular Function)", + "output": "something described as combining with a protein bride of sevenless (boss) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." + }, + { + "input": "Concept: POST CORE TECHNIC (Therapeutic or Preventive Procedure)", + "output": "Crowns described as use of a metal casting, usually with a post in the pulp or root canal, designed to support and retain an artificial crown." + }, + { + "input": "Concept: {Package} (Potency Unit)", + "output": "Quantitative Concept described as a dosing measurement based on the package unit." + }, + { + "input": "Concept: Decreased serum factor b (Finding)", + "output": "Complement Deficiencies described as a reduced level of the complement component factor B in circulation." + }, + { + "input": "Concept: Sulfatide, NOS (Simple organic compound)", + "output": "Cerebrosides described as GLYCOSPHINGOLIPIDS with a sulfate group esterified to one of the sugar groups." + }, + { + "input": "Concept: torsin family 1 member A (Gene or Genome)", + "output": "Gene or Genome described as this gene plays a role in post-translational processing of proteins." + }, + { + "input": "Concept: PLEXD1 (Gene or Genome)", + "output": "PLXND1 gene described as human PLXND1 wild-type allele is located in the vicinity of 3q22.1 and is approximately 52 kb in length. This allele, which encodes plexin-D1 protein, plays a role in semaphorin-mediated signaling." + }, + { + "input": "Concept: Power Lung Device (Medical Devices)", + "output": "Medical Devices described as a handheld breathing device that is used to strengthen the respiratory muscles through resistance training." + }, + { + "input": "Concept: DNA Index (Intellectual Product)", + "output": "Intellectual Product described as the ratio of the DNA content or chromosome number in a tumor sample compared to that in a normal sample." + }, + { + "input": "Concept: Comprehensive prolonged existing in-office 90 minutes (Existing client in-office with ICD diagnosis)", + "output": "something described as evaluating and managing an existing client in a comprehensive, prolonged, 90-minute, in-office meeting. This code may be used by providers of services who are able to diagnose." + }, + { + "input": "Concept: cystadenoma with proliferating activity, ovarian mucinous (cellular diagnosis, borderline ovarian surface epithelial-stromal tumor)", + "output": "something described as a low grade mucinous epithelial neoplasm arising from the ovary. It is characterized by an atypical proliferation of mucinous-type epithelial cells without evidence of stromal invasion. The mucinous epithelial cells may be of intestinal or endocervical type. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C40036\" active clinical trials using this agent." + }, + { + "input": "Concept: Erythrocyte sedimentation rate (& level) (Single-Result Physical Property Test)", + "output": "Measurement described as a quantitative measurement of the distance that red blood cells settle in one hour in a sample of unclotted blood. Used in the evaluation of systemic inflammation." + }, + { + "input": "Concept: Procedures and Techniques Utilization (Statistics as Topic)", + "output": "something described as extent of use of procedures or techniques. It includes overuse and underuse." + }, + { + "input": "Concept: DPTIGGAB (Immunologic Tests)", + "output": "something described as the determination of the amount of the Diphtheria IgG antibodies in a sample." + }, + { + "input": "Concept: induction of host immune response by virus (Cell Function)", + "output": "induction by symbiont of host defense response described as the induction by a virus of an immune response in the host organism." + }, + { + "input": "Concept: Dysuria, CTCAE (Renal and Urinary Disorders, CTCAE)", + "output": "something described as a disorder characterized by painful urination." + }, + { + "input": "Concept: Methyl-5-Aminolevulinate Hydrochloride Cream (Clinical Drug)", + "output": "Clinical Drug described as a topical cream formulation containing the hydrochloride salt of methyl-5-aminolevulinate, a lipophilic methyl ester of 5-aminolevulinic acid, with photosensitizer prodrug activity. Upon topical administration, methyl-5-aminolevulinate in the cream is selectively absorbed by tumor cells where it is converted to the photosensitizer protoporphyrin IX (PpIX). Upon photoirradiation, PpIX is activated and transfers energy to oxygen, generating singlet oxygen and superoxide and hydroxyl radicals, which may result in free-radical-mediated DNA damage and cell death. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2647\" active clinical trials using this agent." + }, + { + "input": "Concept: CSK wt Allele (Gene or Genome)", + "output": "CSK gene described as human CSK wild-type allele is located within 15q23-q25 and is approximately 21 kb in length. This allele, which encodes tyrosine-protein kinase CSK protein, plays a role in signal transduction and intercellular signaling." + }, + { + "input": "Concept: Grade 2 Aortic Valve Disease, CTCAE (Finding)", + "output": "Finding described as asymptomatic; moderate regurgitation or stenosis by imaging" + }, + { + "input": "Concept: ADL02-Talk About TV Content Within a Day (Intellectual Product)", + "output": "Intellectual Product described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, Severe Dementia (ADCS-ADL Severe Dementia) If yes, did subject talk about the content of a program within a day (24 hours) after watching it?" + }, + { + "input": "Concept: Medullary Thyroid Carcinoma cN1a TNM Finding v8 (Medullary Thyroid Carcinoma cN1 TNM Finding v8)", + "output": "something described as metastasis to level VI or VII (pretracheal, paratracheal, or prelaryngeal/Delphian, or upper mediastinal) lymph nodes. This can be unilateral or bilateral disease." + }, + { + "input": "Concept: olfactory nerve maturation (Organ or Tissue Function)", + "output": "cranial nerve maturation described as a developmental process, independent of morphogenetic (shape) change, that is required for the olfactory nerve to attain its fully functional state. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." + }, + { + "input": "Concept: ATP-dependent 3' to 5' DNA/RNA helicase activity (Genetic Function)", + "output": "something described as catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex in the direction 3' to 5'." + }, + { + "input": "Concept: down-regulation of DNA unwinding (regulation of DNA duplex unwinding)", + "output": "negative regulation of chromosome organization described as any process that stops, prevents or reduces the frequency, rate or extent of DNA duplex unwinding." + }, + { + "input": "Concept: Superficial fibromatosis (Fibromatosis)", + "output": "something described as a poorly circumscribed, intermediate fibrocytic neoplasm arising from the superficial soft tissues. It is characterized by the presence of spindle-shaped fibroblasts, and an infiltrative growth pattern." + }, + { + "input": "Concept: TUNICA VAGINALIS (Male Reproductive System Part)", + "output": "Organ component of testis described as serous membrane that covers the testicles." + }, + { + "input": "Concept: Cyclophosphamide/Mechlorethamine/Prednisone/Procarbazine/Vincristine (Therapeutic or Preventive Procedure)", + "output": "Therapeutic or Preventive Procedure described as a chemotherapy combination consisting of cyclophosphamide, mechlorethamine, prednisone, procarbazine, and vincristine." + }, + { + "input": "Concept: Safe Wandering (Finding)", + "output": "Safety described as safe, socially acceptable moving about without apparent purpose in an individual with cognitive impairment" + }, + { + "input": "Concept: Biemond syndrome 1 (Disease or Syndrome)", + "output": "Disease or Syndrome described as cerebellar ataxia, nystagmus, and shortening of the metacarpal and metatarsal bones with mental deficiency and strabismus. Only a few cases have been reported." + }, + { + "input": "Concept: Extra-embryonic celom (Extra-embryonic structure)", + "output": "Extra-embryonic structure described as a large, fluid filled cavity surrounding the amnion and umbilical vesicle, which is first seen in the extraembryonic mesoderm during the second week of gestation, and which quickly expands to form the chorionic cavity." + }, + { + "input": "Concept: FAMILY MYCOPLASMATACEAE (Bacteria, Anaerobic)", + "output": "something described as a taxonomic family of parasitic and pathogenic bacterium, which require sterols to grow, in the phylum Tenericutes that includes the genera Mycoplasma and Ureaplasma." + }, + { + "input": "Concept: Structural Biologist (Research Personnel)", + "output": "Research Personnel described as a science professional who pursues structural analysis of living material at every level of organization by all methods." + }, + { + "input": "Concept: Mediastinal Infection, CTCAE (Infections and Infestations, CTCAE)", + "output": "Finding described as a disorder characterized by an infectious process involving the mediastinum." + }, + { + "input": "Concept: Outer ear abnormality (Ear structure)", + "output": "Abnormality of the outer ear described as a malformation of the auricle of the ear." + }, + { + "input": "Concept: MI, ACUTE (Diagnosis/Diseases Component)", + "output": "Acute heart disease described as necrosis of the myocardium, as a result of interruption of the blood supply to the area. It is characterized by a severe and rapid onset of symptoms that may include chest pain, often radiating to the left arm and left side of the neck, dyspnea, sweating, and palpitations." + }, + { + "input": "Concept: Tuberculosis, Ocular (Eye Infections, Bacterial)", + "output": "Infection due to mycobacterium tuberculosis hominis described as tuberculous infection of the eye, primarily the iris, ciliary body, and choroid." + }, + { + "input": "Concept: Unresectable Fibrosarcoma (Fibrosarcoma)", + "output": "Fibrosarcoma described as a fibrosarcoma that is not amenable to surgical resection." + }, + { + "input": "Concept: Tumor Protein D52-Like 1wt Allele (Gene or Genome)", + "output": "TPD52L1 gene described as human TPD52L1 wild-type allele is located within 6q22-q23 and is approximately 111 kb in length. This allele, which encodes tumor protein D53, may play a role in the regulation of calcium signaling, cellular proliferation and apoptosis." + }, + { + "input": "Concept: adipolysis (organic substance catabolic process)", + "output": "Lysis described as the chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." + }, + { + "input": "Concept: vitamin A import (drug transmembrane transport)", + "output": "vitamin A transport described as the directed movement of vitamin A into a cell or organelle. Vitamin A is any of several retinoid derivatives of beta-carotene, primarily retinol, retinal, or retinoic acid." + }, + { + "input": "Concept: Borrelia burdorferi (Borrelia)", + "output": "Borrelia burgdorferi Group described as a species of bacteria within the phylum Spirochaetes that is the causative agent of Lyme disease." + }, + { + "input": "Concept: MAGEB2 Gene (Gene or Genome)", + "output": "Gene or Genome described as this gene is involved in protein ubiquitination." + }, + { + "input": "Concept: biotin:CoA ligase (Molecular Function)", + "output": "acid-thiol ligase activity described as catalysis of the reaction: ATP + biotin + CoA = AMP + diphosphate + biotinyl-CoA." + }, + { + "input": "Concept: Infection due to Bacteroides (Necrobacillosis)", + "output": "Disease or Syndrome described as infections with bacteria of the genus BACTEROIDES." + }, + { + "input": "Concept: depth (Calculus analysis)", + "output": "Spatial Concept described as extending relatively far inward." + }, + { + "input": "Concept: health care personnel performance (Job Performance)", + "output": "something described as assessment of the functioning of health care employee in relation to work." + }, + { + "input": "Concept: FAC04203 (NCCN-FACT FKSI-19 Version 2 Questionnaire Question)", + "output": "NCCN-FACT FKSI-19 Version 2 Questionnaire Question described as national Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Kidney Symptom Index-19 Version 2 (NCCN-FACT FKSI-19 Version 2) I am losing weight." + }, + { + "input": "Concept: Freezers, Food, Chest (Freezers, Food)", + "output": "something described as food storage freezers with a low height, top-opening (chest) configuration, designed to store food at temperatures typically from 0 to -20 degrees Celsius (32 to -4 degrees Fahrenheit). These freezers are usually made with a corrosion-resistant interior, minimizing the risk of adulteration, contamination, and/or corrosion of contents; they usually include no internal shelving or simple shelving. Chest food storage freezers usually include temperature sensors and controls for dependable long-term storage; they may also include automatic defrost capability. A wide variety of chest freezers with different capacities and shelf configurations are available." + }, + { + "input": "Concept: Autologous CD8+ PBL Sensitized To Drosophila Cell-Presented Melanoma Peptides (Antineoplastic Immune Cell)", + "output": "Cell described as a preparation of autologous CD8+ (cytotoxic) human peripheral blood lymphocytes (PBLs) sensitized to Drosophila cell-presented melanoma peptides, with potential immunostimulating and antineoplastic activities. Autologous CD8+ T-lymphocytes, isolated from a melanoma patient, are exposed in vitro to melanoma peptide-pulsed HLA-A2-expressing Drosophila cells, expanded, and reintroduced into the patient; these tumor-reactive T-cells may stimulate a host immune response against tumor cells expressing the melanoma antigens, resulting in tumor cell lysis. Drosophila cells, which do not express any native MHC molecules, have been shown to potently stimulate tumor-reactivity in vitro from human peripheral blood lymphocytes (PBL) when stably transfected with human MHC molecules and appropriate adhesion and costimulatory molecules." + }, + { + "input": "Concept: SOWS Short (Clinical or Research Assessment Questionnaire)", + "output": "something described as short Opiate Withdrawal Scale (SOWS SHORT) (Gossop, M. The development of a short opiate withdrawal scale. Addictive Behaviors 1990; 15:487-490)." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Trinucleotide Repeats, CAG, PPP2R2B Gene (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Trinucleotide Repeats, CAG)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Trinucleotide Repeats, CAG described as molecular assay reagents intended to identify CAG repeats in the protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform (PPP2R2B) gene, located at chromosome 5q31-q33. Normal alleles have from 7 to 28 CAG trinucleotide repeats.A variation from the expected number of normal CAG trinucleotide repeat copies may produce altered DNA and improper gene functioning, resulting in full mutation. Alleles with from 66 to 78 CAG trinucleotide repeats have been associated with spinocerebellar ataxia type 12 (SCA12)." + }, + { + "input": "Concept: DRRI1-L: Damaging Career Because Deploy (DRRI-2 Questionnaire Question)", + "output": "something described as deployment Risk & Resilience Inventory-2 - During deployment, I was concerned about: damaging my career because of the deployment." + }, + { + "input": "Concept: disease susceptibility (Disorder Characteristics)", + "output": "Study of epidemiology described as a constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases." + }, + { + "input": "Concept: Tobramycin-containing product (Drug allergens)", + "output": "Other aminoglycosides in ATC described as an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species." + }, + { + "input": "Concept: autoradiography (Cytological Techniques)", + "output": "Radiographic imaging procedure described as making a radiograph of an object or tissue by recording the radiation emitted by radioactive material within the object on a photographic plate." + }, + { + "input": "Concept: Tumor Necrosis Factor Ligand Superfamily Member 3 (Receptor)", + "output": "Receptor described as a membrane-bound tumor necrosis family member found primarily on LYMPHOCYTES. It can form a heterotrimer (LYMPHOTOXIN ALPHA1, BETA2 HETEROTRIMER) with the soluble ligand LYMPHOTOXIN-ALPHA and anchor it to the cell surface. The membrane-bound complex is specific for the LYMPHOTOXIN BETA receptor." + }, + { + "input": "Concept: negative regulation of leukocyte migration (Cell Function)", + "output": "negative regulation of cell migration described as any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration." + }, + { + "input": "Concept: Genus Renibacterium (Non-Sporing Gram Positive Rods)", + "output": "Gram-Positive Rods described as a genus of high GC-content, Gram-positive ACTINOBACTERIA in the family MICROCOCCACEAE. The type species of this genus, Renibacterium salmoninarum, is known to cause bacterial kidney disease in SALMONIDS." + }, + { + "input": "Concept: MHRA (Professional Organization or Group)", + "output": "Professional Organization or Group described as the UK government agency responsible for ensuring that medicines and medical devices work, and are acceptably safe." + }, + { + "input": "Concept: L-histidine transmembrane transporter activity (cation transmembrane transporter activity)", + "output": "azole transmembrane transporter activity described as enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid." + }, + { + "input": "Concept: fibroblast proliferation (Cell Function)", + "output": "something described as the multiplication or reproduction of fibroblast cells, resulting in the expansion of the fibroblast population." + }, + { + "input": "Concept: FGF401 inhibitor FGF401 (Organic Chemical)", + "output": "Pharmacologic Substance described as an inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, FGF401 binds to and inhibits the activity of FGFR4, which leads to an inhibition of tumor cell proliferation in FGFR4-overexpressing cells. FGFR4 is a receptor tyrosine kinase upregulated in certain tumor cells and involved in tumor cell proliferation, differentiation, angiogenesis, and survival." + }, + { + "input": "Concept: Brittle diabetes mellitus (Evaluation finding)", + "output": "Disorder of endocrine pancreas described as diabetes mellitus in which there are frequent, clinically significant fluctuations in blood glucose levels both above and below levels expected to be achieved by available therapies." + }, + { + "input": "Concept: Ligamentum collaterale tibiale (Structure of ligament of knee joint)", + "output": "Collateral ligament of knee joint described as the ligament that travels from the medial epicondyle of the FEMUR to the medial margin and medial surface of the TIBIA. The medial meniscus is attached to its deep surface." + }, + { + "input": "Concept: SF-36 v2.0 Acute - Question 9e (SF36 v2 0 Acute Questionnaire Question)", + "output": "SF36 v2 0 Acute Questionnaire Question described as the Short Form 36 Health Survey Acute, Version 2.0 (SF36 v2.0 Acute) Question 9e." + }, + { + "input": "Concept: nrse new hmvst 20min (New client home-visit with nursing diagnosis)", + "output": "New client home-visit with nursing diagnosis described as assessing and/or managing a new client using nursing diagnoses in a usual, 20-minute home-visit. Use this code to describe advanced nursing care without physician oversight. The client may or may not have a medical diagnosis." + }, + { + "input": "Concept: regulation of somatostatin secretion (Cell Function)", + "output": "regulation of peptide hormone secretion described as any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas." + }, + { + "input": "Concept: methane biosynthesis from acetate (methanogenesis)", + "output": "methanogenesis described as the formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other components, including acetate." + }, + { + "input": "Concept: HAM-D6 Self-Report Version - Psychomotor Retardation (HAM-D6 Self-Report Version Questionnaire Question)", + "output": "something described as hamilton Depression Rating Scale 6 Self-Report Version (HAM-D6 Self-Report Version) (4)=Psychomotor retardation, general per clinician version: How you have been feeling over the past three days, including today." + }, + { + "input": "Concept: Ventricular pre-excitation with arrhythmia, NOS (Atrioventricular conduction pattern - finding)", + "output": "Cardiac disorders congenital NEC described as a disorder of the cardiac conduction system of the heart characterized by ventricular preexcitation due to the presence of an abnormal accessory atrioventricular electrical conduction pathway." + }, + { + "input": "Concept: absorption nutrient (Nutrition function)", + "output": "Digestive functions described as functions of passing food and drink nutrients into the blood stream from along the intestines." + }, + { + "input": "Concept: Spine complaint (Sign or Symptom)", + "output": "Nature of Complaint described as spine complaint. Complaint is in the axial skeleton." + }, + { + "input": "Concept: Other Sales and Related Workers (Miscellaneous Occupation)", + "output": "something described as sales and related workers not specifically identified elsewhere." + }, + { + "input": "Concept: MDR3 Positive (Positive Laboratory Test Result)", + "output": "something described as an indication that ABCB4 expression has been detected in a sample." + }, + { + "input": "Concept: Quotient (Quantitative Concept)", + "output": "Quantitative Concept described as a quantity obtained by division." + }, + { + "input": "Concept: Recurrent Metastatic Squamous Cell Carcinoma in the Neck with Occult Primary (Squamous Cell Carcinoma Metastatic in the Neck with Occult Primary)", + "output": "Squamous Cell Carcinoma Metastatic in the Neck with Occult Primary described as the reemergence of metastatic squamous cell carcinoma of unknown primary in the neck region after a period of remission." + }, + { + "input": "Concept: Iliac bone (Body Part, Organ, or Organ Component)", + "output": "Entire bony pelvis described as the broad, dorsal, upper, and widest of the three principal bones composing either half of the pelvis." + }, + { + "input": "Concept: Ethanesulfonic acid, compd. with 3-chloro-4-[4-[2-chloro-4-(4,6-diamino-2,2-dimethyl-1,3, 5-triazin-1(2H)-yl)phenyl]butyl]benzenesulfonyl fluoride (1:1) (Pharmacologic Substance)", + "output": "Folic Acid Antagonists described as a synthetic dihydrotriazine derivative with antineoplastic properties. As an antifolate agent related to methotrexate (MTX), triazinate inhibits the enzyme dihydrofolate reductase (DHFR), resulting in decreased tetrahydrofolate production and interference with thymidylate synthesis. Unlike MTX, this agent is not converted to polyglutamate forms. Triazinate also inhibits the transport of folates and may be selectively toxic to MTX-resistant tumor cells." + }, + { + "input": "Concept: (mL/d)/(ug/kg) (Unit of Dose Calculation)", + "output": "something described as a unit of concentration equal to liter per day divided by milligram per kilogram." + }, + { + "input": "Concept: AML99 (Study Identifier)", + "output": "something described as the identifier AML99, assigned to a study in a clinical trial." + }, + { + "input": "Concept: Fungal Vaccines (Pharmacologic Substance)", + "output": "something described as suspensions of attenuated or killed fungi administered for the prevention or treatment of infectious fungal disease." + }, + { + "input": "Concept: GALL STONE (Disease digestive system other)", + "output": "HEPATIC: OBSTRUCTIVE described as the presence of calculi in the gallbladder." + }, + { + "input": "Concept: Locally Advanced Bladder Urothelial Carcinoma (Locally Advanced Bladder Carcinoma)", + "output": "Metastatic Bladder Urothelial Carcinoma described as a bladder urothelial carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes." + }, + { + "input": "Concept: GASTRIC CURVATURE LYMPH NODE (Lymph Node by Anatomic Site)", + "output": "Lymph Node by Anatomic Site described as lymph node(s) located between the two layers of the greater omentum, either superiorly along the cardiac half of the lesser curvature of the stomach or inferiorly along the pyloric half of the greater curvature of the stomach." + }, + { + "input": "Concept: microradiography (Radiographic imaging procedure)", + "output": "Diagnostic Procedure described as process by which a radiograph of a small or very thin object is produced on photographic film under conditions permitting subsequent microscopic examination or high resolution enlargement of the radiograph." + }, + { + "input": "Concept: PIK3CA c.1625A>T (Cell or Molecular Dysfunction)", + "output": "something described as a nucleotide substitution at position 1625 of the coding sequence of the PIK3CA gene where adenine has been mutated to thymine." + }, + { + "input": "Concept: Prostheses, Ankle, Semi-Constrained, Cemented, Metal/Polymer (Medical Device)", + "output": "Medical Device described as an ankle joint metal/polymer semi-constrained cemented prosthesis is a device intended to be implanted to replace an ankle joint. The device limits translation and rotation in one or more planes via the geometry of its articulating surfaces and has no linkage across-the-joint. This generic type of device includes prostheses that have a talar resurfacing component made of alloys, such as cobalt-chromium-molybdenum, and a tibial resurfacing component made of ultra-high molecular weight polyethylene and is limited to those prostheses intended for use with bone cement (Sec. 888.3027)." + }, + { + "input": "Concept: Hepatitis (Disease or Syndrome)", + "output": "Abnormal liver morphology described as INFLAMMATION of the LIVER." + }, + { + "input": "Concept: FAC016-I Have Pain (Intellectual Product)", + "output": "something described as functional Assessment of Cancer Therapy-Lung Version 4 (FACT-L Version 4) Physical Well-Being: I have pain." + }, + { + "input": "Concept: falciparums, Plasmodium (Family Plasmodiidae)", + "output": "Blood sporozoan described as a species of protozoa that is the causal agent of falciparum malaria (MALARIA, FALCIPARUM). It is most prevalent in the tropics and subtropics." + }, + { + "input": "Concept: SAME-SEX SEXUAL CONTACT (Individual Behavior)", + "output": "something described as sexual contact with someone of the same sex." + }, + { + "input": "Concept: posterior transverse temporal area 42 (Brodmann area)", + "output": "Body Location or Region described as a subdivision of the cytoarchitecturally defined temporal region of cerebral cortex. It is located in the bank of the lateral fissure on the dorsal surface of the temporal lobe. Cytoarchitecturally it is bounded medially by the area 41 of Brodmann (human) and laterally by the area 22 of Brodmann (human) ( Brodmann-1909 )." + }, + { + "input": "Concept: Sutures, Synthetic, Nonabsorbable, Nylon, Multifilament (Medical Device)", + "output": "something described as synthetic sutures consisting of multifilament nylon fibers made from nonabsorbable (i.e., nonbiodegradable) aliphatic polymers. These sutures are typically available in sterile braided coated thread sections (e.g., 18, 30 in [45, 76 cm] long) attached to a single-use needle as an integral device; they are frequently colored for easy identification during surgery. Nylon sutures keep their tensile strength for very long periods of time; nylon is not absorbed, but hydrolysis may result in gradual loss of tensile strength over time. Nylon nonabsorbable synthetic braided sutures are characterized by their excellent handling properties; their intended use includes suturing internal organs and tissues." + }, + { + "input": "Concept: Congenital primary megaureter (Congenital dilatation of ureter)", + "output": "Idiopathic dilation of ureter described as an idiopathic condition in which the bladder and bladder outlet are normal but the ureter is dilated to some extent. It may be obstructed, refluxing or unobstructed and not refluxing. Prevalence is unknown, but is the second most common cause of neonatal hydronephrosis. About half of cases are asymptomatic and are discovered on routine antenatal ultrasound. The cause is unknown but it may be due to high fetal urine outflow, changes in the ureter pre and postnatal or transient anatomical obstructions that improve with postnatal development, such as ureteral folds. Not known to be hereditary, but families with more than one affected member have been described." + }, + { + "input": "Concept: Grade 1 Neonatal Sinus Tachycardia, Adverse Event (Neonatal Sinus Tachycardia, Adverse Event)", + "output": "Finding described as brief, self-limiting, episodes of tachycardia; no care changes." + }, + { + "input": "Concept: Focal aware sensory seizure with cephalic sensation (Focal sensory seizure with cephalic sensation)", + "output": "something described as a seizure characterized by a sensation in the head such as light-headedness or headache." + }, + { + "input": "Concept: Micrococcus (Bacterium)", + "output": "Micrococcaceae described as genus of gram positive, spherical bacteria found in soils and fresh water, and frequently on the skin of man and other animals." + }, + { + "input": "Concept: Stage III Testicular Cancer AJCC v7 (Neoplastic Process)", + "output": "Testicular Cancer by AJCC v6 and v7 Stage described as stage III is divided into stage IIIA, stage IIIB, and stage IIIC, and is determined after a radical inguinal orchiectomy (surgery to remove the testicle) is done. In stage IIIA, cancer is anywhere within the testicle, spermatic cord, or scrotum; may have spread to one or more lymph nodes in the abdomen; and has spread to distant lymph nodes or to the lungs; tumor marker levels may range from normal to slightly above normal. In stage IIIB, cancer is anywhere within the testicle, spermatic cord, or scrotum; and may have spread to one or more lymph nodes in the abdomen, to distant lymph nodes or to the lungs; the level of one or more tumor markers is moderately above normal. In stage IIIC, cancer is anywhere within the testicle, spermatic cord, or scrotum; and may have spread to one or more lymph nodes in the abdomen, to distant lymph nodes, or to the lungs; the level of one or more tumor markers is high; OR, cancer is anywhere within the testicle, spermatic cord, or scrotum; and may have spread to one or more lymph nodes in the abdomen; and has not spread to distant lymph nodes or the lung but has spread to other parts of the body; tumor marker levels may range from normal to high." + }, + { + "input": "Concept: interstitial cell of Cajal differentiation (neuroepithelial cell differentiation)", + "output": "intestinal epithelial cell differentiation described as the process in which a relatively unspecialized cell acquires specialized features of an interstitial cell of Cajal. An interstitial cell of Cajal is an intestinal neuroepithelial cell that serves as a pacemaker to trigger gut contraction." + }, + { + "input": "Concept: PKR2 (PRKAR2A gene)", + "output": "something described as human PRKAR2A wild-type allele is located within 3p21.3-p21.2 and is approximately 103 kb in length. This allele, which encodes cAMP-dependent protein kinase type II-alpha regulatory subunit protein, plays a role in the modulation of cyclic AMP-dependent signaling." + }, + { + "input": "Concept: FAC023-I Have Nausea (Intellectual Product)", + "output": "FACT-P Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Prostate Version 4 - Physical Well-Being: I have nausea." + }, + { + "input": "Concept: Somewhat Bothered (Finding)", + "output": "Finding described as a subject score of 2 on a symptoms extent scale that ranges from 0: Not at All to 4: Very Bothered." + }, + { + "input": "Concept: Secondary Language Spoken (Property or Attribute)", + "output": "Property or Attribute described as additional language(s) that is spoken by the subject but not considered the primary language." + }, + { + "input": "Concept: transitional one stage B-lymphocyte differentiation (Cell Function)", + "output": "something described as the process in which immature B cells from the bone marrow acquire the specialized features of T1 stage B cells in the spleen. T1 stage B cells do not express either CD23 or CD21." + }, + { + "input": "Concept: Mammary Gland, Animal (Body Part, Organ, or Organ Component)", + "output": "Exocrine Glands described as MAMMARY GLANDS in the non-human MAMMALS." + }, + { + "input": "Concept: Intrahepatic Cholangiocarcinoma by AJCC v8 Stage (Neoplastic Process)", + "output": "Neoplastic Process described as a term that refers to the staging of intrahepatic cholangiocarcinoma according to the American Joint Committee on Cancer, 8th edition." + }, + { + "input": "Concept: Smoke paper (Solid Dose Form)", + "output": "Solid Dose Form described as a pharmaceutical dosage form in paper; when lit, it delivers medicated smoke." + }, + { + "input": "Concept: plasma membrane proton-transporting ATP synthase complex (plasma membrane protein complex)", + "output": "Cell Component described as a proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient." + }, + { + "input": "Concept: VISMODEGIB (Substance with smoothened receptor antagonist mechanism of action)", + "output": "V [Preparations] described as a substance being studied in the treatment of cancer. It blocks a type of protein involved in tissue growth and repair and may block the growth of cancer cells. It is a type of Hedgehog signaling pathway antagonist." + }, + { + "input": "Concept: OLIG 2 Protein (Amino Acid, Peptide, or Protein)", + "output": "Basic Helix-Loop-Helix Transcription Factors described as a basic helix-loop-helix transcription factor that is required for differentiation of OLIGODENDROCYTES and motor neurons in the spinal cord, and development of somatic motor neurons in the hindbrain." + }, + { + "input": "Concept: tapetum formation (developmental process involved in reproduction)", + "output": "Physiologic Function described as the process that gives rise to the anther wall tapetum. This process pertains to the initial formation of a structure from unspecified parts. The anther wall tapetum is a layer of cells that provides a source of nutrition for the pollen grains as they mature." + }, + { + "input": "Concept: Otolaryngic Allergy - Physicians (Professional or Occupational Group)", + "output": "Professional or Occupational Group described as an otolaryngologist who specializes in the diagnosis and treatment of otolaryngic allergies and other allergic diseases." + }, + { + "input": "Concept: exodeoxyribonuclease III activity (Genetic Function)", + "output": "something described as catalysis of the degradation of double-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides." + }, + { + "input": "Concept: Iterative Reconstruction (Radionuclide Imaging)", + "output": "something described as a method of reconstruction used in PET and SPECT that repeats a series of calculation steps with image data such that there is an improvement in the image quality in each repetition. It is an alternative approach to filtered backprojection." + }, + { + "input": "Concept: regulation of vesicle-mediated transport involved in floral organ abscission by small GTPase mediated signal transduction (small GTPase mediated signal transduction)", + "output": "Molecular Function described as any series of molecular signals in which a small monomeric GTPase relays one or more of the signals that modulates the rate or extent of floral organ abscission." + }, + { + "input": "Concept: ADL0120 (ADCS-ADL Questionnaire Question)", + "output": "something described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory - In the past 4 weeks, did {S} read a magazine, newspaper or book for more than 5 minutes at a time?" + }, + { + "input": "Concept: Full (General Qualifier)", + "output": "General Qualifier described as containing as much or as many as is possible or normal." + }, + { + "input": "Concept: Device Exposure (Domain)", + "output": "something described as a subject domain utilized for the submission of information encompassing and representing data, vocabulary or records related to device exposure." + }, + { + "input": "Concept: reaper hid grim domain binding (Protein Binding)", + "output": "Protein Binding described as interacting selectively and non-covalently with an RHG (reaper/hid/grimm) domain/motif (AKA iap binding motif)." + }, + { + "input": "Concept: NCI Initial Review Group (Component of the Division of Extramural Activities)", + "output": "Component of the Division of Extramural Activities described as an Initial Review Group reviews grant and cooperative agreement applications for centers, research projects, and research training activities in the areas of cancer cause, diagnosis, treatment, and prevention; and contract proposals relating to all facets of cancer." + }, + { + "input": "Concept: integral component of postsynaptic specialization membrane of symmetric synapse (intrinsic component of postsynaptic specialization membrane of symmetric synapse)", + "output": "Cell Component described as the component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." + }, + { + "input": "Concept: Inspection of palm crease (Intellectual Product)", + "output": "Intellectual Product described as when examining the infant's palm for abnormalities, the examiner may note a single transverse palmar crease, which is found in 5% of newborns and is frequently inherited as a familial trait. However, single palmar creases can be associated with Down's syndrome and other genetic disorders, or with fetal alcohol syndrome." + }, + { + "input": "Concept: Shroud kit (Medical Device)", + "output": "something described as prepackaged collections of the devices and supplies (either custom or standard) needed for providing physical care of the body of a deceased person (i.e., cadaver). Items in these kits usually include cadaver bags, identification labels (e.g., toe tags or ankle bands), chin straps/ties, absorbent pads, and string or other appropriate materials (e.g., for securing the cadaver's limbs). These kits may be supplied in supporting trays (i.e., procedure trays) consisting of a flat-bottomed receptacle with a border around the periphery supporting all the instruments and supplies needed for the procedure. Postmortem care procedure kits and trays are intended for use in preparing cadavers for transfer to the morgue/mortuary." + }, + { + "input": "Concept: Refrigeration System Equipment (Electromechanical Devices)", + "output": "something described as combinations of devices (units), ancillary devices, and accessories designed to provide low temperatures above the freezing point of water (i.e., 0 degrees Celsius [32 degrees Fahrenheit]), typically from 2 to 10 degrees Celsius (35 to 50 degrees Fahrenheit), to a walk-in enclosure (i.e., a chamber) especially designed for this purpose or conditioned from an existing healthcare facility room. This equipment typically consists of compressors, fans, evaporators, ducted-air distribution systems, thermometers, temperature controls, and warming systems to balance the temperature; it may also include a recording temperature chart and alarms for dependable long-term storage. The characteristics of the equipment depend on the size, location, and intended use of the chamber (e.g., food storage, laboratory, morgue)." + }, + { + "input": "Concept: Body of the Spermatozoon (Male Reproductive System Part)", + "output": "Cell Component described as a part of a sperm cell, also known as the middle piece, between the head and the tail consisting of the neck and connection piece. This area contains a large number of mitochondria that produce energy to power the tail." + }, + { + "input": "Concept: Food, Drugs, and Medical Devices Regulatory Document (Intellectual Product)", + "output": "Document type described as a regulatory document encompassed by or derived from the CFR Title 21." + }, + { + "input": "Concept: positive regulation of histone H3-K9 methylation (positive regulation of histone methylation)", + "output": "something described as any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3." + }, + { + "input": "Concept: Prosthetic Valve Dysfunction (Cardiovascular finding)", + "output": "Finding described as malfunction of a surgically-placed cardiac valve related to the valve itself or the area around the valve." + }, + { + "input": "Concept: Enflurane-containing product (Halogenated hydrocarbons, general anesthetics)", + "output": "General anesthetic drugs described as an extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate." + }, + { + "input": "Concept: BACS - Number of Tokens Correctly Placed (Intellectual Product)", + "output": "Intellectual Product described as brief Assessment of Cognition in Schizophrenia Questionnaire - Token Motor Task-Number of tokens correctly placed." + }, + { + "input": "Concept: Between no restrictions and recreational restrictions only (Clinical or Research Assessment Answer)", + "output": "Clinical or Research Assessment Answer described as a response indicating that a person's functional extremity restrictions are at an intermediate level between no restrictions and recreational restrictions only." + }, + { + "input": "Concept: Manduca Hubner, 1807 (Lepidoptera)", + "output": "Eukaryote described as large grey moth; larval form of this genus is known to do considerable damage to the commercially important plants they feed on." + }, + { + "input": "Concept: Removal of embolus, NOS (Cardiovascular Surgical Procedures)", + "output": "something described as surgical removal of an obstructing clot or foreign material which has been transported from a distant vessel by the bloodstream. Removal of a clot at its original site is called THROMBECTOMY." + }, + { + "input": "Concept: HIV1MONA (Human immunodeficiency virus test)", + "output": "something described as the determination of the amount of HIV-1 group M and O nucleic acid present in a sample." + }, + { + "input": "Concept: copper chelate transmembrane transporter activity (Molecular Function)", + "output": "copper ion transmembrane transporter activity described as enables the transfer of a copper chelate from one side of a membrane to the other. A copper chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions." + }, + { + "input": "Concept: Dendritic (neuron component)", + "output": "Nerve Tissue described as one of the threadlike extensions of the cytoplasm of a neuron, which typically branch into tree-like processes; in unipolar and bipolar neurons, there is a single dendrite, which proximally resembles an axon but branches distally; in multipolar neurons there are many short, branching dendrites; dendrites compose most of the receptive surface of a neuron; called also dendron, neurodendrite, and neurodendron." + }, + { + "input": "Concept: selenite reductase activity (Molecular Function)", + "output": "oxidoreductase activity, acting on NAD(P)H described as catalysis of the reaction: SeO3(2-) + 3NADPH + 5H+ = H2Se + 3NADP+ + 3H2O." + }, + { + "input": "Concept: AVL01038 (ADNI-AVLT Questionnaire Question)", + "output": "Intellectual Product described as alzheimer's Disease Neuroimaging Initiative Auditory Verbal Learning Test Version A (ADNI-AVLT Version A) List A, Recall 3, Word 4." + }, + { + "input": "Concept: propionyl-CoA carboxylase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA." + }, + { + "input": "Concept: practice guidelines (Guidelines)", + "output": "Intellectual Product described as works about directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery." + }, + { + "input": "Concept: Alfentanilo (Opioid Receptor Agonist)", + "output": "Organic Chemical described as a synthetic short-acting opioid with analgesic and local anesthesia enhancing activity. Alfentanil primarily binds to mu-opioid receptor, a G-protein-coupled receptor, thereby mimicking the actions of morphine, the prototypical mu receptor agonist. This agent induces anti-nociception responses mediated through inhibiting the release of various neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline; in addition, the release of vasopressin, somatostatin, insulin and glucagon are also inhibited." + }, + { + "input": "Concept: NP2 (Pharmacologic Substance)", + "output": "Gene Transfer or Gene Delivery Agent described as a replication-defective (ICP4-deleted) herpes simplex virus type 1 (HSV-1) viral vector expressing the human preproenkephalin A (PPE) gene with potential antinociceptive activity. Upon intradermal administration, PPE-expressing replication-defective HSV-1 vector NP2 is transported by retrograde axonal transport to the dorsal root ganglion (DRG) and becomes dormant. In the DRG, the vector transduces sensory neurons with high efficiency, delivering the engineered PPE gene; transduced neurons then express the protein proenkephalin A, the precursor for Met- and Leu-enkephalin. After proteolytic cleavage from proenkephalin A in the DRG neuronal cytosol, transgene-mediated Met- and Leu-enkephalin bind to mu and gamma- opioid receptors, which may result in the inhibition of nociceptive neurotransmission. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C79845\" active clinical trials using this agent." + }, + { + "input": "Concept: Bat Skin Tumor (Experimental Organism Neoplasm by Organism)", + "output": "Experimental Organism Neoplasm by Organism described as a skin tumor that occurs in a bat." + }, + { + "input": "Concept: CHD (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as choline dehydrogenase, mitochondrial (594 aa, ~65 kDa) is encoded by the human CHDH gene. This protein is involved in the conversion of choline to betaine." + }, + { + "input": "Concept: Limit (Numerical value)", + "output": "something described as a value approached but never reached." + }, + { + "input": "Concept: PQL1310 (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Teen Questionnaire Question)", + "output": "Intellectual Product described as pediatric Quality of Life Neuromuscular Module Acute Version 3.0 Parent Report for Teen (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Teen) In the past 7 days, how much of a problem has this been for your teen: It is hard for my child to gain or lose weight when he or she wants to." + }, + { + "input": "Concept: Pseudotuberculoses, Pasteurella (Disease or Syndrome)", + "output": "Disease or Syndrome described as infections with bacteria of the species YERSINIA PSEUDOTUBERCULOSIS." + }, + { + "input": "Concept: hyaluronidase / rituximab (Pharmacologic Substance)", + "output": "Antineoplastic Antibody described as a combination preparation of rituximab, a genetically engineered chimeric murine/human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against the CD20 antigen, and the recombinant form of the human enzyme hyaluronidase, with antineoplastic activity. Upon subcutaneous administration of rituximab and hyaluronidase human, the hyaluronidase reversibly depolymerizes the polysaccharide hyaluronan in the subcutaneous tissue. This increases the permeability of the subcutaneous tissue and enhances the absorption of rituximab into the systemic circulation. In turn, rituximab targets and binds to CD20 expressed on tumor cells, and induces tumor cell lysis primarily through the induction of complement dependent cytotoxicity (CDC) and antibody-dependent cell mediated cytotoxicity (ADCC). When administered subcutaneously, hyaluronidase, an endoglycosidase, increases the dispersion and absorption of co-administered drugs. CD20 is expressed on the surface of pre-B and mature B-lymphocytes, and is overexpressed in a variety of B-cell malignancies." + }, + { + "input": "Concept: Eye and Vision Services Providers; Optometrist (Medical Occupation)", + "output": "Optometrist AND/OR optician described as a physician with a Doctor of Optometry degree (or analogous) who specializes in the diagnosis and treatment of eye disorders." + }, + { + "input": "Concept: Apgar score, NOS (Adaptive behavior: newborn)", + "output": "Fetal sign described as a method, developed by Dr. Virginia Apgar, to evaluate a newborn's adjustment to extrauterine life. Five items - heart rate, respiratory effort, muscle tone, reflex irritability, and color - are evaluated 60 seconds after birth and again five minutes later on a scale from 0-2, 0 being the lowest, 2 being normal. The five numbers are added for the Apgar score. A score of 0-3 represents severe distress, 4-7 indicates moderate distress, and a score of 7-10 predicts an absence of difficulty in adjusting to extrauterine life." + }, + { + "input": "Concept: Have Eye Pain in Wind (Clinical or Research Assessment Question)", + "output": "Clinical or Research Assessment Question described as a question about whether an individual's eyes hurt because of the wind." + }, + { + "input": "Concept: colicin transmembrane transporter activity (bacteriocin transmembrane transporter activity)", + "output": "something described as enables the transfer of a colicin from one side of a membrane to the other. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1." + }, + { + "input": "Concept: indium (111In) capromab pendetide (Indium Radioisotopes)", + "output": "Radioconjugate described as a radioimmunoconjugate consisting of the murine IgG1 kappa monoclonal antibody capromab (7E11-C5.3), conjugated to the linker-chelator glycyl-tyrosyl-(N,-diethylenetriaminepentaacetic acid)-lysine hydrochloride (GYK-DTPA-HCl) and labeled with radioisotope indium In 111, with ligand-binding and gamma-emitting activities. Upon intravenous administration, indium In 111-capromab pendetide binds to a cytoplasmic epitope of human prostate specific membrane antigen (PSMA) expressed on prostate tumor cell surfaces via its capromab moiety and, upon internalization, allows radioimmunolocalization with gamma scintigraphy. PSMA is a cell surface glycoprotein abundantly expressed by prostate epithelium and is typically overexpressed by prostate cancer cells." + }, + { + "input": "Concept: Disintegrant (Pharmaceutical Excipient)", + "output": "Pharmaceutical Excipient described as disintegrant excipient is a therapeutically inactive ingredient of a solid pharmaceutical dosage form that helps the form to dissolve within the gastrointestinal tract to ensure full release of the pharmaceutically active material. Disintegration rate of the tablet may be the rate limiting step for the absorption of the drug. Currently, disintegrants have been developed to the point that disintegration is not usually the rate limiting step. The US Pharmacopeia sets a time limit for disintegration. Microcrystalline cellulose and starch are examples of disintegrants." + }, + { + "input": "Concept: macromolecule transmembrane transporter activity (Molecular Function)", + "output": "transmembrane transporter activity described as enables the transfer of a macromolecule from one side of a membrane to the other." + }, + { + "input": "Concept: undef.Wstrn hrb&ntrl subst l (Classification)", + "output": "Western herbs and natural substances letter F described as any elsewhere undefined Western herb and natural substance, letter F, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com." + }, + { + "input": "Concept: Dietary Silicon (dietary mineral)", + "output": "dietary mineral described as forms of the element silicon found in foods." + }, + { + "input": "Concept: regulation of cardiac myofibril development (regulation of actomyosin structure organization)", + "output": "regulation of organelle assembly described as any process that modulates the frequency, rate or extent of cardiac myofibril assembly." + }, + { + "input": "Concept: Sporadic (Genetic Inheritance)", + "output": "Mode of inheritance described as cases of the disease in question occur without a previous family history, i.e., as isolated cases without being transmitted from a parent and without other siblings being affected." + }, + { + "input": "Concept: SLIT-ROBO Rho GTPase activating protein 3 (Signaling Pathway Gene)", + "output": "Gene or Genome described as this gene plays a role in GTPase-mediated signaling." + }, + { + "input": "Concept: 7: 26993083-26983451 (Chromosome 7 Physical Location)", + "output": "Spatial Concept described as physical location of HOXA10_Gene" + }, + { + "input": "Concept: ERBB2 signaling pathway (Signal Transduction Pathways)", + "output": "ERBB Family Signaling Pathway described as her2 or ERBB2 belongs to a class of proteins having high homology with epidermal growth factor receptor (EGFR or ERBB1). It encodes a protein with a molecular weight of 185 KDa. Unlike other members of the EGFR family, no ligand for Her2 has been found and it usually associates with members of ERBB1 family to form functional heterodimers. It has been shown that it can form dimers with ERBB (EGFR), ERBB3 and ERBB4 as well as gp130 subunits of IL-6 receptor. In at least some cell types, the association between gp130 and HRBB2 is essential for HRBB2-ERBB3 phosphorylation and subsequent MAP kinase signaling. Although ERBB1 can form homodimers, the signaling for ERBB1 is usually transient and the receptor undergoes internalization after ligand binding and activation. EGFR-HER2 complex increases the signaling capacity of EGFR by increasing the ligand affinity as well as the recycling of the heterodimer. Of all the ERBB heterodimers, ERBB2-ERBB3 heterodimers perhaps elicit the strongest signal. Removing ERBB3 from the cell has a drastic effect on ERBB2 mediated signaling and downstream effectors. The clinical importance of HER2 cannot be overstated. In addition, monoclonal antibody (Herceptin) against this receptor has been shown to be an effective treatment of breast cancer patients who have a high level of HER2 over expression." + }, + { + "input": "Concept: up regulation of protein targeting to vacuolar membrane (positive regulation of vacuolar transport)", + "output": "positive regulation of protein targeting to membrane described as any process that activates or increases the frequency, rate or extent of protein targeting to vacuolar membrane." + }, + { + "input": "Concept: Myeloid Proliferation Index (Blood Cell Count Ratio Measurement)", + "output": "Laboratory Procedure described as a relative measurement (ratio) of the sum of myeloid proliferative phase cells (pool) to the sum of myeloid maturation phase cells (pool) in a biological specimen." + }, + { + "input": "Concept: Food and Water Consumption End Day (Observation End Day)", + "output": "something described as the final day of the food and water consumption assessment." + }, + { + "input": "Concept: E2F-4 Transcription Factor (E2F transcription factors)", + "output": "Amino Acid, Peptide, or Protein described as an E2F transcription factor that represses GENETIC TRANSCRIPTION required for CELL CYCLE entry and DNA synthesis. E2F4 recruits chromatin remodeling factors indirectly to target gene PROMOTER REGIONS through RETINOBLASTOMA LIKE PROTEIN P130 and RETINOBLASTOMA LIKE PROTEIN P107." + }, + { + "input": "Concept: Stage IIIA Small Intestinal Adenocarcinoma AJCC v8 (Neoplastic Process)", + "output": "Neoplastic Process described as stage IIIA includes: Any T, N1, M0. N1: Metastasis in one or two regional lymph nodes. M0: No distant metastasis. (AJCC 8th ed.) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C133900\" active clinical trials using this agent." + }, + { + "input": "Concept: Clear cell meningioma (Neoplasm, uncertain whether benign or malignant)", + "output": "something described as a WHO grade II morphologic variant of meningioma characterized by the presence of clear glycogen-rich polygonal cells." + }, + { + "input": "Concept: American Indians, Central (Canadian and Latin American Indian race)", + "output": "something described as the native people of Central America." + }, + { + "input": "Concept: Aorta.abdominal (Body Part, Organ, or Organ Component)", + "output": "Structure of artery of abdomen proper described as the lower part of the aorta in the abdomen prior to its bifurcation to the iliac arteries, whose pulse can be palpated at the level of the umbilicus." + }, + { + "input": "Concept: N-Acetylglucosaminyl-N-acetyhnuramyl-L-Ala-isoGlu-L-Ala-glycerol Dipalmitate (Chemo Immunostimulant Adjuvant)", + "output": "something described as a lipophilic disaccharide tripeptide derivative of muramyl dipeptide (MDP) with immunomodulatory activity. Disaccharide tripeptide glycerol dipalmitoyl (DTP-GDP)stimulates macrophage activity and increases serum levels of tumor necrosis factor alpha (TNF alpha), neopterin, interleukin (IL)-1 alpha, IL-1 beta, IL-6, IL-8, and IL-12, which may activate host immune system antitumor functions. DTP-GDP may be packaged in liposomes for improved delivery. The immunomodulatory effects of this agent may be superior to those of MDP. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1575\" active clinical trials using this agent." + }, + { + "input": "Concept: Barrier Device (Device Component or Accessory)", + "output": "something described as something that blocks, prevents, separates, or limits." + }, + { + "input": "Concept: Erythrocyte sedimentation rate (ESR) abnormal (erythrocyte sedimentation rate result)", + "output": "Abnormality of metabolism/homeostasis described as a deviation from normal range of the erythrocyte sedimentation rate (ESR), a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. An elevation may indicate inflammation or may be caused by any condition that elevates fibrinogen. A decreased ESR may be seen in polycythemia or in certain blood diseases in which red blood cells have an irregular or smaller shape that causes slower settling." + }, + { + "input": "Concept: Connective Tissue of Villus (Other Embryologic Structure)", + "output": "Embryonic Structure described as a type of fibrous tissue that provides cohesion and support to the intra-villus structures, and constitutes the bulk of the villus." + }, + { + "input": "Concept: macromolecule biosynthesis (Molecular Function)", + "output": "macromolecule metabolic process described as the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." + }, + { + "input": "Concept: How Motivated to Exercise (Clinical or Research Assessment Question)", + "output": "Intellectual Product described as a question about an individual's motivation level for exercise." + }, + { + "input": "Concept: Left Main Coronary Artery Stenosis (Disease or Syndrome)", + "output": "something described as percent luminal narrowing of the left main coronary artery, at the point of maximal stenosis of the left main coronary artery." + }, + { + "input": "Concept: Process, Physical (Physical Sciences)", + "output": "Natural Phenomenon or Process described as a natural phenomenon involving the physics of matter and energy." + }, + { + "input": "Concept: Does your health now limit you in doing vigorous activities, such as running, lifting heavy objects, participating in strenuous sports (Intellectual Product)", + "output": "Intellectual Product described as a question about whether an individual's current health limits them in doing vigorous activities." + }, + { + "input": "Concept: Nucleotide Biochemistry (Occupation or Discipline)", + "output": "Biochemistry described as the branch of biochemistry that is specifically concerned with the structure, synthesis, maintenance and biological pathways that involve nucleotides." + }, + { + "input": "Concept: opsin binding (Molecular Function)", + "output": "something described as interacting selectively and non-covalently with an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception." + }, + { + "input": "Concept: FCAS (Chronic disease of immune function)", + "output": "Cryopyrin-Associated Periodic Syndromes described as an autoinflammatory disease caused by mutations in the NLRP3 gene which encodes cryopyrin. It is characterized by short episodes of fever, rash, and arthralgia after exposure to cold or rapid decrease in temperature." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Clinical Chemistry, Nitrogen Metabolite, Blood Urea Nitrogen (IVD Test Reagent/Kits, Clinical Chemistry, Nitrogen Metabolite)", + "output": "something described as clinical chemistry reagents intended to perform qualitative and/or quantitative chemical analysis of body fluids (typically blood or serum) to determine the level of urea in blood, usually referred to as blood urea nitrogen (BUN). An increase in BUN is referred as azotemia, typically caused by renal failure." + }, + { + "input": "Concept: Infections, Torovirus (Coronaviridae Infections)", + "output": "Disease or Syndrome described as infections with viruses of the genus TOROVIRUS, family CORONAVIRIDAE." + }, + { + "input": "Concept: TMJ ajstmnt ea.ajstmnt (Nonspinal adjustments)", + "output": "something described as applying force by hand to a client's osseous and/or adjacent soft tissue structures of the temporomandibular joint to restore his or her normal anatomical and/or physiological structure and/or function. Service is billed per adjustment." + }, + { + "input": "Concept: Sunitinib Regimen (Regimen Used to Treat Malignant Soft Tissue Neoplasm)", + "output": "Regimen Used to Treat Bone Cancer described as a chemotherapy regimen consisting of sunitinib that may be used in the treatment of soft tissue sarcomas (including alveolar soft part sarcomas); follicular, medullary, papillary, Hurthle cell thyroid carcinomas; thymic carcinomas and thymomas; gastrointestinal stromal tumors (GISTs); kidney and bone cancers; solitary fibrous tumor/hemangiopericytoma; and pancreatic neuroendocrine tumors (NETs)." + }, + { + "input": "Concept: glycuronidase activity (Molecular Function)", + "output": "hydrolase activity, hydrolyzing O-glycosyl compounds described as catalysis of the hydrolysis of glucuronosides, yielding free glucuronic acid." + }, + { + "input": "Concept: up regulation of skeletal muscle acetylcholine-gated channel clustering (positive regulation of receptor clustering)", + "output": "positive regulation of receptor clustering described as any process that activates or increases the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering." + }, + { + "input": "Concept: Modular Medical Facilities, Stationary, Single Photon Emission Tomography (Medical Device)", + "output": "Medical Device described as stationary modular medical facilities that are typically divided into a single photon emission computed tomography (SPEC) scanning area and a control room, including the operator console, and could also include an auxiliary equipment (e.g., electric generator, air conditioning) room. These facilities consist of a gamma (scintillation) camera used as a detector, a patient table, and a computer subsystem, including dedicated software, display monitors, and a data-storage unit." + }, + { + "input": "Concept: regulation of transcription open complex formation at RNA polymerase II promoter (regulation of transcription initiation from RNA polymerase II promoter)", + "output": "regulation of transcription initiation from RNA polymerase II promoter described as any process that modulates the rate, frequency or extent of a process involved the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." + }, + { + "input": "Concept: MAJOR PATHOLOGIC RESPONSE (Disease Response)", + "output": "something described as a major decrease in signs of cancer, supported by pathological examination and based on pre-defined thresholds." + }, + { + "input": "Concept: substance K receptor activity (tachykinin receptor activity)", + "output": "Molecular Function described as combining with substance K, the peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met, to initiate a change in cell activity." + }, + { + "input": "Concept: release of sequestered calcium ion into postsynaptic cytosol (Cell Function)", + "output": "something described as the process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the postsynaptic cytosol." + }, + { + "input": "Concept: nuclear polyadenylation-dependent tRNA catabolic process (Genetic Function)", + "output": "nuclear polyadenylation-dependent ncRNA catabolic process described as the chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of an aberrant or incorrectly modified transfer RNA (tRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target tRNA." + }, + { + "input": "Concept: StudyObjective (objective)", + "output": "something described as a goal that the study is aiming to achieve in terms of a scientific question to be answered by the analysis of data collected during the study. EXAMPLE(S): To extend the life of study participants by at least 3 years. To determine efficacy of Drug X dose 1, dose 2, and dose 3 as measured by the percentage of subjects experiencing headache relief. To compare overall survival in subjects with [type of cancer] who have received [prior treatment] and who are randomized to treatment with either Combination A+B or single-agent B. To select a Drug X dose for further evaluation based on comparison of the short-term antiviral activity, safety, and tolerability of different oral doses of Drug X in combination with Drug Y in HIV-1 infected therapy-naive subjects. To compare the proportion of subjects developing a rash in subjects administered dermatological precautions (DP) versus subjects administered usual care precautions (UC) during 12 weeks of treatment of Drug X in [disease description] subjects. To obtain exploratory descriptive information on the relationship of tobacco use, alcohol use and dietary patterns on toxicity and outcomes in males and females. OTHER NAME(S): NOTE(S): StudyProtocolVersion.purposeStatement, StudyProtocolVersion.primaryPurposeTypeCode and StudyObjective may sound similar in meaning but are distinct concepts in BRIDG. StudyProtocolVersion.purposeStatement, which is an broad explanation of why a study is being conducted (e.g. determine efficacy of a drug or procedure), differs from StudyProtocolVersion.primaryPurposeTypeCode which is a classification of the purpose or intent of the study (e.g. Prevention, Treatment, Quality of Life), and that differs from StudyObjective, which describes in a specific and measurable way what the study hopes to accomplish (e.g. extend life of subjects at least 3 years, reduce frequency of symptoms)." + }, + { + "input": "Concept: Matricaria recutita topical infusion (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as a gel-based formulation containing an extract of the herb Matricaria chamomilla (M. recutita or German chamomile), which is native to eastern and southern Europe, belongs to the Asteraceae family and is high in flavonoids, with potential anti-inflammatory, skin protective, moisturizing, anti-bacterial, anti-oxidant and calming activities. M. recutita extract contains flavonoids, including apigenin, luteolin and quercetin, as well as coumarins, herniarin, umbelliferone, anthemic acid, anthemidine, tannin and matricarin. Upon topical application of the Matricaria recutita infusion, the active ingredients in the chamomile may exert anti-inflammatory, calming and anti-oxidant effects on the skin and may protect the skin against radiotherapy-induced dermatitis." + }, + { + "input": "Concept: Shortening of all metacarpals (Short metacarpal)", + "output": "Anatomical Abnormality described as abnormal reduction in length of all metacarpal bones." + }, + { + "input": "Concept: Leminorella richardii (Bacterium)", + "output": "Bacterium described as any bacterial organism that can be assigned to the species Leminorella richardii." + }, + { + "input": "Concept: archaeal proton-transporting A-type ATPase complex (proton-transporting two-sector ATPase complex)", + "output": "Cell Component described as a large proton-transporting two-sector ATPase protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane and is found in Archaea." + }, + { + "input": "Concept: aluminum transport (Cell Function)", + "output": "metal ion transport described as the directed movement of aluminum (Al) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." + }, + { + "input": "Concept: histone H2B conserved C-terminal lysine ubiquitination (Molecular Function)", + "output": "Molecular Function described as a histone ubiquitination process in which a ubiquitin monomer is added to a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, or K120 in mammals." + }, + { + "input": "Concept: Pathways (Miscellaneous Molecular Biology Terms)", + "output": "something described as a set or series of interactions, often forming a network, which biologists have found useful to group together for organizational, historic, biophysical, or other reasons." + }, + { + "input": "Concept: Whole Body Emergency Immobilizers, Infant (Medical Device)", + "output": "something described as whole-body emergency immobilizers designed for maximum restriction of movement and/or immobilization of an infant's entire body. These immobilizers usually consist of rigid structures (typically a backboard) with a size appropriate for use in infants that permit the rigid attachment of the child's entire body. The board is frequently made of light metallic or hard plastic radiolucent materials. Infant whole body immobilizers are mainly used after traumatic injuries in emergency situations, allowing easy transportation and/or diagnosis. Dedicated infant immobilizers mainly intended for circumcision procedures are also available." + }, + { + "input": "Concept: Cutaneous Melanoma pT2 TNM Finding (Finding)", + "output": "something described as cutaneous melanoma 1.01 to 2 mm in thickness, with or without ulceration." + }, + { + "input": "Concept: LAMP, INFRARED, PHYSICAL MEDICINE (Medical Device)", + "output": "Medical Device described as an infrared lamp is a device intended for medical purposes that emits energy at infrared frequencies (approximately 700 nanometers to 50,000 nanometers) to provide topical heating." + }, + { + "input": "Concept: Transverse - anatomical location (Dental)", + "output": "Planar anatomical coordinate described as a cross-sectional view of the brain commonly presented in illustrations of its internal structure. Roughly speaking, the term refers to a horizontal plane that extends from the front to the back of the brain. For a more precise definition of its use in BrainInfo see \\\" plane of section \\\". For a comprehensive review and discussion of uses of this and related terms by different authors, see ( Anthoney-1994 )." + }, + { + "input": "Concept: Refractory Soft Tissue Sarcoma, Excluding Rhabdomyosarcoma (Neoplastic Process)", + "output": "Soft Tissue Sarcoma, Excluding Rhabdomyosarcoma described as a finding indicating the presence of a sarcoma arising from the soft tissue, other than rhabdomyosarcoma, that is resistant to treatment." + }, + { + "input": "Concept: Measurements, Bone Age (Diagnostic Procedure)", + "output": "Diagnostic Procedure described as a measure of the developmental stage of bone tissue." + }, + { + "input": "Concept: Erythrophagocytic Lymphohistiocytoses, Familial (Disease or Syndrome)", + "output": "Haematological disorders congenital NEC described as rare form of hemophagocytic lymphohistiocytosis with multiorgan involvement seen in infants and young children" + }, + { + "input": "Concept: acetate salt (Organic Chemical)", + "output": "A [Preparations] described as salt or ester form of acetic acid. Acetate is the most common building block for biosynthesis, such as fatty acids." + }, + { + "input": "Concept: Non-classic CLAH (Disease or Syndrome)", + "output": "Familial glucocorticoid deficiency described as a variant of familial glucocorticoid deficiency caused by a defect in the steroidogenic acute regulatory protein; it may mimic lipoid congenital adrenal hyperplasia." + }, + { + "input": "Concept: seclidemstat (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as an orally available, reversible, noncompetitive inhibitor of lysine-specific demethylase 1 (LSD1, or KDM1A), with potential antineoplastic activity. Upon oral administration, seclidemstat reversibly inhibits LSD1, a demethylase that suppresses the expression of target genes by converting the di- and mono-methylated forms of lysine at position 4 of histone 3 (H3K4) to mono- and unmethylated H3K4, respectively. LSD1 inhibition enhances H3K4 methylation and increases the expression of tumor suppressor genes. This may lead to an inhibition of cell growth in LSD1-overexpressing tumor cells. In addition, LSD1 demethylates mono- or di-methylated H3K9 which increases gene expression of tumor promoting genes; inhibition of LSD1 promotes H3K9 methylation and decreases transcription of these genes." + }, + { + "input": "Concept: regulation of penile erection (regulation of multi-organism process)", + "output": "regulation of reproductive process described as any process that modulates the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." + }, + { + "input": "Concept: Cancer Models Database (Databases)", + "output": "something described as the cancer Models Database (caMOD) allows researchers to retrieve and submit animal models of cancer. caMOD currently supports the Mouse Models of Human Cancer Consortium (MMHCC)." + }, + { + "input": "Concept: Chloroplasts (Experimental Organism Anatomical Concept)", + "output": "Cell Component described as photosynthetic organelle containing chlorophyll, the photosynthetic pigment, in cells of leaves and young stems of higher plants. Lens-shaped and rather variable in size but approximately 5 m long. Surrounded by a double membrane and contains circular DNA (though not enough to code for all proteins in the chloroplast). Like the mitochondrion, it is semi-autonomous. It resembles a cyanobacterium from which, on the endosymbiont hypothesis, it might be derived. Chlorophyll is associated with the membrane of vesicles (thylakoids) that are stacked to form grana." + }, + { + "input": "Concept: None (Finding)", + "output": "Clinical or Research Assessment Answer described as a response indicating that a person requires no physical support." + }, + { + "input": "Concept: Defined (Document type)", + "output": "ObservationQualityMeasureAttribute described as a concise explanation of the meaning of a word or phrase or symbol." + }, + { + "input": "Concept: Chlorambucil Regimen (Therapeutic or Preventive Procedure)", + "output": "Regimen Used to Treat Chronic Lymphocytic Leukemia described as a chemotherapy regimen consisting of chlorambucil that may be used in the treatment of chronic lymphocytic leukemia (CLL), small lymphocytic leukemia (SLL),and follicular lymphoma (grade 1-2)." + }, + { + "input": "Concept: Stage IIA2 (Stage IIA Cervix)", + "output": "something described as a stage term that applies to cervical cancer and indicates that the tumor invades beyond the uterus but not to the pelvic wall or to the lower third of vagina. There is no parametrial invasion. The lesion is clinically visible and measures more than 4.0 cm in greatest dimension." + }, + { + "input": "Concept: IDH1R132H-specific Peptide Vaccine (Amino Acid, Peptide, or Protein)", + "output": "something described as a peptide vaccine consisting of a 20-mer peptide derived from isocitrate dehydrogenase type 1 (IDH1) containing the point mutation R132H (IDH1R132H), with potential antineoplastic activity. Upon subcutaneous vaccination with the IDH1R132H mutation-targeting IDH1 peptide vaccine, the vaccine stimulates the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells that express the IDH1R132H protein. R132H is a point mutation, which contains an amino acid substitution where arginine is replaced by histidine at position 132 of IDH1, and is highly expressed in gliomas as well as other tumor types; this mutation is associated with increased production of the oncometabolite R-2-hydroxyglutarate (2HG)." + }, + { + "input": "Concept: Ampule - unit of product usage (Quantitative Concept)", + "output": "Potency Unit described as a dosing unit equal to the amount of active ingredient(s) contained in an ampule." + }, + { + "input": "Concept: TSTSFRPT (Laboratory Procedure)", + "output": "something described as a relative measurement (ratio or percentage) of free testosterone to total proteins in a biological specimen." + }, + { + "input": "Concept: Platelet Aggregation Test (Hematologic Tests)", + "output": "Assay described as the determination of the amount of the association of platelets to one another via adhesion molecules in a biological sample." + }, + { + "input": "Concept: Left Brain (Body Part, Organ, or Organ Component)", + "output": "Neuroanatomy described as used only when the left hemisphere of the brain is the focus of the document." + }, + { + "input": "Concept: Prostheses, Toe, Constrained, Polymer (Medical Device)", + "output": "Medical Device described as a toe joint polymer constrained prosthesis is a device made of silicone elastomer or polyester reinforced silicone elastomer intended to be implanted to replace the first metatarsophalangeal (big toe) joint. This generic type of device consists of a single flexible across-the-joint component that prevents dislocation in more than one anatomic plane." + }, + { + "input": "Concept: G0 G1 Switch Regulatory Protein 24 (Biologically Active Substance)", + "output": "TRANSCRIPTION FACTOR described as a ZINC FINGER MOTIF containing transcription factor that was originally identified as one of the IMMEDIATE-EARLY PROTEINS. It shuttles between the CYTOPLASM and the CELL NUCLEUS and is involved in destabilization of mRNAs for TUMOR NECROSIS FACTOR-ALPHA." + }, + { + "input": "Concept: Fifth finger distal phalanx clinodactyly (Abnormality of the distal phalanx of the 5th finger)", + "output": "Clinodactyly of the 5th finger described as bending or curvature of the distal phalanx of little finger in the radial direction (i.e., towards the 4th finger)." + }, + { + "input": "Concept: Vesicles, Transport (Membranous cytoplasmic organelle)", + "output": "Cell Component described as vesicles that are involved in shuttling cargo from the interior of the cell to the cell surface, from the cell surface to the interior, across the cell or around the cell to various locations." + }, + { + "input": "Concept: DPDTAVG (Finding)", + "output": "Myocardial Contractility Measurement described as the average rate of pressure change over time within the left ventricle (systole)." + }, + { + "input": "Concept: Type II Secretory Phospholipase A2 Measurement (Laboratory Procedure)", + "output": "something described as the determination of the type II secretory phospholipase A2 present in a sample." + }, + { + "input": "Concept: Absent isohemagglutinin level (Finding)", + "output": "Finding described as absent or undetectable level of isohemagglutinin. An isohemagglutinin refers to the naturally occurring antibodies in the ABO blood group system (i.e., anti-A in a group B person, anti-B in a group A person, and anti-A, anti-B, and anti-A,B in a group O person)." + }, + { + "input": "Concept: regulation of thyroid-stimulating hormone secretion (regulation of peptide hormone secretion)", + "output": "Cell Function described as any process that modulates the frequency, rate or extent of thyroid-stimulating hormone secretion." + }, + { + "input": "Concept: Ingestion dermatitis:food (Chemical-induced dermatological disorder)", + "output": "Ingestion dermatitis described as dermatitis caused by an allergic reaction to ingested food." + }, + { + "input": "Concept: Calcification Indicator (Indicator)", + "output": "Indicator described as an indication as to whether calcification is present." + }, + { + "input": "Concept: ocular flutter (Head finding)", + "output": "Eye described as ocular flutter is an abnormal eye movement consisting of repetitive, irregular, involuntary bursts of horizontal saccades without an intersaccadic interval. It is generally superimposed on normal oculomotor behaviour and its occurrence may be favoured by various events, such as blinks, the triggering of normal saccades or optokinetic stimulation." + }, + { + "input": "Concept: Bevacizumab-Cisplatin-Pemetrexed (Therapeutic or Preventive Procedure)", + "output": "Regimen Used to Treat Non-Small Cell Lung Carcinoma described as a chemoimmunotherapy regimen consisting of bevacizumab, cisplatin and pemetrexed that is used for the treatment of non-small cell lung cancer (NSCLC)." + }, + { + "input": "Concept: Grade 4 Hypoxia (Hypoxia, CTCAE)", + "output": "something described as life-threatening airway compromise; urgent intervention indicated" + }, + { + "input": "Concept: Intracellular Transport (Biological Transport)", + "output": "Biological Transport described as any subcellular or molecular event, process, or condition involved in translocation of a biological macromolecule from one site or compartment to another, entirely within a cell." + }, + { + "input": "Concept: Over the past seven days what was the severity of your decreased appetite at its worst (Findings-Based Question)", + "output": "Intellectual Product described as a question about an individual's observation of the worst severity they have experienced related to decreased appetite over the past seven days." + }, + { + "input": "Concept: Multiple Osteochondromas (Cartilaginous exostosis)", + "output": "Osseous AND/OR chondromatous neoplasm described as a condition marked by the presence of multiple osteochondromas." + }, + { + "input": "Concept: ethanolamine biosynthetic process (Molecular Function)", + "output": "primary amino compound biosynthetic process described as the chemical reactions and pathways resulting in the formation of ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine)." + }, + { + "input": "Concept: Primary Endpoint (End Point)", + "output": "Indicator, Reagent, or Diagnostic Aid described as the main result that is measured at the end of a study to see if a given treatment worked (e.g., the number of deaths or the difference in survival between the treatment group and the control group). What the primary endpoint will be is decided before the study begins." + }, + { + "input": "Concept: NBPhox (PHOX2B gene)", + "output": "something described as human PHOX2B wild-type allele is located in the vicinity of 4p12 and is approximately 5 kb in length. This allele, which encodes paired mesoderm homeobox protein 2B, is involved in the modulation of gene expression. Mutation of the gene is associated with both congenital central hypoventilation syndrome and susceptibility to neuroblastoma type 2." + }, + { + "input": "Concept: Resectoscope (Endoscopes)", + "output": "Medical Device described as an endoscope and accessories is a device used to provide access, illumination, and allow observation or manipulation of body cavities, hollow organs, and canals. The device consists of various rigid or flexible instruments that are inserted into body spaces and may include an optical system for conveying an image to the user's eye and their accessories may assist in gaining access or increase the versatility and augment the capabilities of the devices. Examples of devices that are within this generic type of device include cleaning accessories for endoscopes, photographic accessories for endoscopes, nonpowered anoscopes, binolcular attachments for endoscopes, pocket battery boxes, flexible or rigid choledochoscopes, colonoscopes, diagnostic cystoscopes, cystourethroscopes, enteroscopes, esophagogastroduodenoscopes, rigid esophagoscopes, fiberoptic illuminators for endoscopes, incandescent endoscope lamps, biliary pancreatoscopes, proctoscopes, resectoscopes, nephroscopes, sigmoidoscopes, ureteroscopes, urethroscopes, endomagnetic retrievers, cytology brushes for endoscopes, and lubricating jelly for transurethral surgical instruments. This section does not apply to endoscopes that have specialized uses in other medical specialty areas and that are covered by classification regulations in other parts of the device classification regulations." + }, + { + "input": "Concept: Mendelian susceptibility to mycobacterial disease due to complete ISG15 (interferon stimulated gene 15) deficiency (Disease or Syndrome)", + "output": "Immunodeficiency associated with chromosomal abnormality described as a genetic variant of mendelian susceptibility to mycobacterial diseases characterised by Bacille Calmette-Guerin (BCG) infections. The prevalence is unknown. Caused by mutations in the ISG15 gene (1p36.33), which encodes an IFN-alpha/beta inducible, ubiquitin-like intracellular protein. These mutations impair ISG15 secretion by leucocytes, a molecule which plays an essential role as an IFN-gamma-inducing secreted molecule needed for optimal antimycobacterial immunity. Inherited in an autosomal recessive manner." + }, + { + "input": "Concept: Partial absence of finger (Abnormal finger phalanx morphology)", + "output": "Finding described as the absence of a phalangeal segment of a finger." + }, + { + "input": "Concept: MIR15A Pre-miRNA (pre-miRNA)", + "output": "Nucleic Acid, Nucleoside, or Nucleotide described as MIR15A pre-miRNA is an oligoribonucleotide that is encoded by the human MIR15A gene and is involved in the regulation of gene expression." + }, + { + "input": "Concept: myosin head/neck binding (myosin heavy chain binding)", + "output": "myosin heavy chain binding described as interacting selectively and non-covalently with the head/neck region of a myosin heavy chain." + }, + { + "input": "Concept: Penile Cancer pT4 TNM Finding v8 (Finding)", + "output": "Finding described as penile cancer with tumor invading into adjacent structures (i.e., scrotum, prostate, pubic bone)." + }, + { + "input": "Concept: bevacizumab-IRDye 800CW (Immunologic Factor)", + "output": "Organic Chemical described as an immunoconjugate and a fluorescent tracer consisting of the recombinant humanized anti-vascular endothelial growth factor (VEGF) monoclonal antibody bevacizumab conjugated to the N-hydroxysuccinamide (NHS) ester form of the near-infrared (NIR) fluorescent dye IRDye 800CW, that may be used for VEGF-specific tumor imaging. Upon administration, the bevacizumab moiety of bevacizumab-IRDye 800CW binds to VEGF and the fluorescent signal can be visualized using NIR fluorescence imaging (700-1,000 nm). Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C101261\" active clinical trials using this agent." + }, + { + "input": "Concept: oxaloacetate metabolic process (dicarboxylic acid metabolic process)", + "output": "something described as the chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle." + }, + { + "input": "Concept: MALTOSE (Sugars/Sugar metabolism)", + "output": "Sugars/Sugar metabolism described as a dextrodisaccharide from malt and starch. It is used as a sweetening agent and fermentable intermediate in brewing." + }, + { + "input": "Concept: monoterpene biosynthetic process (monoterpene metabolic process)", + "output": "monoterpene metabolic process described as the chemical reactions and pathways resulting in the formation of monoterpenes, terpenes with a C10 structure." + }, + { + "input": "Concept: Genus Cronobacter (Enterobacteriaceae)", + "output": "Enterobacteriaceae described as a genus of facultatively anaerobic, Gram negative, rod shaped bacterium in the phylum Proteobacteria and the family Enterobacteriaceae." + }, + { + "input": "Concept: DP1 (Gene or Genome)", + "output": "something described as human TFDP1 wild-type allele is located in the vicinity of 13q34 and is approximately 56 kb in length. This allele, which encodes transcription factor Dp-1 protein, is involved in the regulation of apoptosis, gene transcription, and cell cycle progression." + }, + { + "input": "Concept: isovaleryl-CoA(4-) formation (isovaleryl-CoA(4-) metabolic process)", + "output": "Molecular Function described as the chemical reactions and pathways resulting in the formation of isovaleryl-CoA(4-)." + }, + { + "input": "Concept: DDB1- and Cul4-associated factor 1, human (Amino Acid, Peptide, or Protein)", + "output": "Ubiquitination Regulation Protein described as DDB1- and CUL4-associated factor 1 (1507 aa, ~169 kDa) is encoded by the human DCAF1 gene. This protein plays a role in both serine/threonine-protein kinase activity and E3 ubiquitin-protein ligase complex substrate recognition." + }, + { + "input": "Concept: MIRN29B2 (Gene or Genome)", + "output": "MicroRNA Gene described as this gene is involved in the regulation of gene expression. and plays a role in the development of carcinoma of the lung, cholangiocarcinoma, chronic lymphocytic leukemia, acute myeloid leukemia, rhabdomyosarcoma, Alzheimer's disease and Type II diabetes." + }, + { + "input": "Concept: cardiocyte development (Cell Function)", + "output": "something described as the process whose specific outcome is the progression of a cardiac cell over time, from its formation to the mature state. A cardiac cell is a cell that will form part of the cardiac organ of an individual." + }, + { + "input": "Concept: Inhalation Spacers (Medical Device)", + "output": "something described as devices intended to be used with nebulizers or metered-dose inhalers (MDIs) for the purpose of minimizing the delivery of large aerosolized particles, thereby increasing the percentage of inhaled medication that reaches the lower airways. Inhalation spacers typically consist of a tube-shaped reservoir that connects to the outlet of the nebulizer/MDI at its distal end and to the patient's mouth at the proximal end. Some inhalation spacers, termed valved holding chambers, incorporate a one-way valve that aids in regulating inspiratory flow and prevents patients from exhaling into the device." + }, + { + "input": "Concept: anlotinib hydrochloride (Antineoplastic Enzyme Inhibitor)", + "output": "Angiogenesis Inhibitors described as the hydrochloride salt form of anlotinib, a receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic and anti-angiogenic activities. Upon administration, anlotininib targets multiple RTKs, including vascular endothelial growth factor receptor type 2 (VEGFR2) and type 3 (VEGFR3). This agent may both inhibit angiogenesis and halt tumor cell growth. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C106428\" active clinical trials using this agent." + }, + { + "input": "Concept: X-linked intellectual disability and hypotonia with facial dysmorphism and aggressive behaviour syndrome (Disorder of skeletal muscle)", + "output": "Mental Retardation described as this syndrome is characterised by severe intellectual deficit, hypotonia, mild facial dysmorphism and aggressive behaviour. It has been described in 10 male members spanning four generations of one family. The facial dysmorphism includes a high forehead, prominent ears, and a small pointed chin. Height and head circumference are reduced. This disorder is transmitted as an X-linked recessive trait and the causative gene maps to Xp22." + }, + { + "input": "Concept: Diffuse telangiectases (Finding)", + "output": "something described as telangiectases (small dilated blood vessels) with a diffuse localization." + }, + { + "input": "Concept: E3-Binding Protein (Structural protein)", + "output": "Structural protein described as pyruvate dehydrogenase protein X component, mitochondrial (501 aa, ~54 kDa) is encoded by the human PDHX gene. This protein plays a role in anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complex." + }, + { + "input": "Concept: Concanavalin A (Amino Acid, Peptide, or Protein)", + "output": "something described as mannose/glucose binding lectin isolated from the jack bean (Canavalia ensiformis); potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures." + }, + { + "input": "Concept: Sarcomatosis of Meninges (Meningioma)", + "output": "something described as a rare condition characterized by diffuse spread of sarcoma cells throughout the meninges. The neoplastic cells are derived from meningeal connective tissue. Clinically, this disorder may present as a fulminant pachymeningitis and/or encephalitis." + }, + { + "input": "Concept: Borrelia burdorferi (Borrelia species)", + "output": "Borrelia burgdorferi Group described as any bacterial organism that can be assigned to the species Borrelia burgdorferi." + }, + { + "input": "Concept: noncontiguous lymphoma (Finding)", + "output": "Finding described as a term that usually refers to the clinical course of lymphomas and indicates that the cancerous lymph nodes are not next to each other, but are on the same side of the diaphragm." + }, + { + "input": "Concept: Sutures, Natural, Absorbable (Medical Device)", + "output": "Medical Device described as an absorbable surgical gut suture, both plain and chromic, is an absorbable, sterile, flexible thread prepared from either the serosal connective tissue layer of beef (bovine) or the submucosal fibrous tissue of sheep (ovine) intestine, and is intended for use in soft tissue approximation." + }, + { + "input": "Concept: bilirubin elevated (Metabolic finding)", + "output": "Thermoregulation status: newborn described as excessive concentrations of bilirubin in the blood, which may lead to jaundice." + }, + { + "input": "Concept: Visual Signal Transduction Pathway (Signal Transduction Pathways)", + "output": "Cell Function described as the signal transduction cascade responsible for sensing light in vertebrates is one of the best studied signal transduction processes, and is initiated by rhodopsin in rod cells, a member of the G-protein coupled receptor gene family. Rhodopsin remains the only GPCR whose structure has been resolved at high resolution. Rhodopsin in the discs of rod cells contains a bound 11-cis retinal chromophore, a small molecule derived from Vitamin A that acts as the light sensitive portion of the receptor molecule, absorbing light to initiate the signal transduction cascade. When light strikes 11-cis retinal and is absorbed, it isomerizes to all-trans retinal, changing the shape of the molecule and the receptor it is bound to. This change in rhodopsin's shape alters its interaction with transducin, the member of the G-protein gene family that is specific in its role in visual signal transduction. Activation of transducin causes its alpha subunit to dissociate from the trimer and exchange bound GDP for GTP, activating in turn a membrane-bound cyclic-GMP specific phosphodiesterase that hydrolyzes cGMP. In the resting rod cell, high levels of cGMP associate with a cyclic-GMP gated sodium channel in the plasma membrane, keeping the channels open and the membrane of the resting rod cells depolarized. This is distinct from synaptic generation of action potentials, in which stimulation induces opening of sodium channels and depolarization. When cGMP gated channels in rod cells open, both sodium and calcium ions enter the cell, hyperpolarizing the membrane and initiating the electrochemical impulse responsible for conveying the signal from the sensory neuron to the CNS. The rod cell in the resting state releases high levels of the inhibitory neurotransmitter glutamate, while the release of glutamate is repressed by the hyperpolarization in the presence of light to trigger a downstream action potential by ganglion cells that convey signals to the brain. The calcium which enters the cell also activates GCAP, which activates guanylate cyclase (GC-1 and GC-2) to rapidly produce more cGMP, ending the hyperpolarization and returning the cell to its resting depolarized state. A protein called recoverin helps mediate the inactivation of the signal transduction cascade, returning rhodopsin to its preactivated state, along with the rhodopsin kinase Grk1. Phosphorylation of rhodopsin by Grkl causes arrestin to bind, helping to terminate the receptor activation signal. Dissociation and reassociation of retinal, dephosphorylation of rhodopsin, and release of arrestin all return rhodopsin to its ready state, prepared once again to respond to light." + }, + { + "input": "Concept: positive regulation of proline metabolic process (positive regulation of cellular amino acid metabolic process)", + "output": "something described as any process that activates or increases the frequency, rate or extent of proline metabolic process." + }, + { + "input": "Concept: syndrome, Piriformis (Syndrome)", + "output": "disorders of peripheral nerve, neuromuscular junction and muscle described as a chronic PELVIC PAIN characterized by pain deep in the buttock that may radiate to posterior aspects of the leg. It is caused by the piriformis muscle compressing or irritating the SCIATIC NERVE due to trauma, hypertrophy, inflammation or anatomic variations." + }, + { + "input": "Concept: Swimmers' itch (Site-specific disorder of skin)", + "output": "Site-specific disorder of skin described as an unusual presentation of schistosomiasis characterized by a pruritic papular rash in the perigenital or periumbilical area due to an allergic reaction to schistosoma eggs deposited in the skin." + }, + { + "input": "Concept: intramuscular (Intra-location)", + "output": "Spatial Concept described as within or into muscle." + }, + { + "input": "Concept: RADIOIMMUNOASSAY, DIGOXIN (125-I), RABBIT ANTIBODY, SOLID PHASE SEP. (Indicator, Reagent, or Diagnostic Aid)", + "output": "Indicator, Reagent, or Diagnostic Aid described as a digoxin test system is a device intended to measure digoxin, a cardiovascular drug, in serum and plasma. Measurements obtained by this device are used in the diagnosis and treatment of digoxin overdose and in monitoring levels of digoxin to ensure appropriate therapy." + }, + { + "input": "Concept: ERT - Total Negative Stimuli Completed (ERT Functional Test Question)", + "output": "Intellectual Product described as emotion Recognition - Total number of negative emotion stimuli (face images) actually completed in the task." + }, + { + "input": "Concept: sulphate assimilation via adenylyl sulphate reduction (sulfate assimilation)", + "output": "Molecular Function described as the pathway by which inorganic sulfate is activated, reduced and incorporated into sulfated compounds, where the activated sulfate, adenylyl-sulfate, is reduced to sulfite by the activity of adenylyl-sulfate reductase." + }, + { + "input": "Concept: APUD Cells (Anatomical set)", + "output": "Endocrine Cells described as an endocrine cell that has the capabilities of amine precursor uptake and decarboxylation, and low molecular weight polypeptide hormone secretion." + }, + { + "input": "Concept: Malonates (Organic Chemical)", + "output": "Organic Chemical described as derivatives of malonic acid (the structural formula CH2(COOH)2), including its salts and esters." + }, + { + "input": "Concept: palmitoleoyltransferase activity (transferase activity, transferring acyl groups other than amino-acyl groups)", + "output": "something described as catalysis of the transfer of a palmitoleyl group, a 16-carbon monounsaturated fatty acid (C16:1), to an acceptor molecule." + }, + { + "input": "Concept: NIAID (United States National Institutes of Health)", + "output": "United States National Institutes of Health described as component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports basic and applied research to better understand, treat, and ultimately prevent infectious, immunologic, and allergic diseases. It was established in 1948." + }, + { + "input": "Concept: Reconstruction of Raw Data Type (Imaging Technology)", + "output": "Imaging Technology described as the type of mathematical process used to produce the displayed image from the raw k-space data obtained from the receiver circuitry." + }, + { + "input": "Concept: rRNA primary transcript binding (Genetic Function)", + "output": "something described as interacting selectively and non-covalently with an unprocessed ribosomal RNA transcript." + }, + { + "input": "Concept: protein localisation involved in acrosome reaction (Reproductive process)", + "output": "Cell Function described as the actin-based process in which a protein is transported to, or maintained in, a specific location in the sperm as part of the acrosome reaction." + }, + { + "input": "Concept: PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Teen - Hands Are Weak (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Teen Questionnaire Question)", + "output": "Intellectual Product described as pediatric Quality of Life Neuromuscular Module Acute Version 3 Teen Parent Report - In the past 7 days, how much of a problem has this been for your teen: My child's hands are weak." + }, + { + "input": "Concept: 4,5-Diaminopyridine (OTHER NERVOUS SYSTEM DRUGS in ATC)", + "output": "neurological agents described as an organic compound derived from pyridine with potassium channel inhibition activity. Amifampridine inhibits potassium channel efflux, increasing the duration of the action potential, which results in an increase in the duration of calcium channel opening and enhanced acetylcholine (ACh) release. Increased ACh availability at the motor end plate allows muscles to contract. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C82687\" active clinical trials using this agent." + }, + { + "input": "Concept: Distance Perception (Mental Process)", + "output": "Space Perception described as the act of knowing or the recognition of a distance by recollective thought, or by means of a sensory process which is under the influence of a set of prior experiences." + }, + { + "input": "Concept: Paclitaxel Injectable Emulsion (paclitaxel)", + "output": "something described as a cremophor-free, P-glycoprotein-inhibiting, vitamin E-based emulsion particle formulation of paclitaxel with antineoplastic activity. Paclitaxel binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. This agent also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein B-cell Leukemia 2 (Bcl-2). The vitamin-E based emulsion allows bolus infusion without steroid premedication and may diminish hypersensitivity reactions. The tumor tissue may be passively targeted due to preferential deposition of emulsion particles while an emulsion formulation component inhibits the P-glycoprotein drug efflux pump." + }, + { + "input": "Concept: BELOTECAN HYDROCHLORIDE (Pharmacologic Substance)", + "output": "something described as the hydrochloride salt of the semi-synthetic camptothecin analogue belotecan with potential antitumor activity. Belotecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. Topoisomerase I is an enzyme that mediates reversible single-strand breaks in DNA during DNA replication." + }, + { + "input": "Concept: Thermotoga maritima (Thermotoga)", + "output": "Thermotoga described as a rod-shaped bacterium surrounded by a sheath-like structure which protrudes balloon-like beyond the ends of the cell. It is thermophilic, with growth occurring at temperatures as high as 90 degrees C. It is isolated from geothermally heated marine sediments or hot springs." + }, + { + "input": "Concept: Echocardiography, Doppler Pulsed (Diagnostic Procedure)", + "output": "Ultrasonography, Doppler, Pulsed described as echocardiography applying the Doppler effect, with velocity detection combined with range discrimination. Short bursts of ultrasound are transmitted at regular intervals and the echoes are demodulated as they return." + }, + { + "input": "Concept: Osteocyte (SKELETAL SYSTEM: GENERAL TERMS)", + "output": "Osteoblasts described as mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi." + }, + { + "input": "Concept: Birt Hogg Dube Syndrome (Hereditary disorder of the integument)", + "output": "Autosomal dominant hereditary disorder described as autosomal dominant neoplastic syndrome characterised by genodermatosis, lung cysts, spontaneous and recurrent PNEUMOTHORAX; and RENAL CANCER. It is associated with mutations in the folliculin protein gene (FLCN protein)." + }, + { + "input": "Concept: TAMPON (Biomedical or Dental Material)", + "output": "something described as a solid single-dose form consisting of a suitable material intended for insertion into a body cavity for a limited time prior to removal." + }, + { + "input": "Concept: RESTRAINT, WHEELCHAIR, NON-PROTECTIVE (Medical Device)", + "output": "Medical Device described as a wheelchair accessory is a device intended for medical purposes that is sold separately from a wheelchair and is intended to meet the specific needs of a patient who uses a wheelchair. Examples of wheelchair accessories are the following: armboard, lapboard, pusher cuff, crutch and cane holder, restraint, overhead suspension sling, head and trunk support, and blanket and leg rest strap." + }, + { + "input": "Concept: Lymphocyte Function (Lymphocyte Cell Biology)", + "output": "Lymphocyte Cell Biology described as cell biology studies concerned with understanding the functioning of lymphocytes." + }, + { + "input": "Concept: succinate-citramalate CoA-transferase activity (CoA-transferase activity)", + "output": "something described as catalysis of the reaction: S-citramalate + succinyl-CoA = citramalyl-CoA + succinate." + }, + { + "input": "Concept: Type 3 Voltage Gated Sodium Channel (Biologically Active Substance)", + "output": "something described as a voltage-gated sodium channel subtype found in neuronal tissue that mediates the sodium ion PERMEABILITY of excitable membranes." + }, + { + "input": "Concept: CCR5 chemokine receptor binding (CCR chemokine receptor binding)", + "output": "Molecular Function described as interacting selectively and non-covalently with a CCR5 chemokine receptor." + }, + { + "input": "Concept: synaptobrevin 2-SNAP-25-syntaxin-4 complex (Cell Component)", + "output": "SNARE complex described as a SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 4 (or orthologs thereof)." + }, + { + "input": "Concept: Grade 3 Syncope, CTCAE (Finding)", + "output": "Syncope, CTCAE 5.0 described as fainting; orthostatic collapse" + }, + { + "input": "Concept: Darlingtonia californica / California pitcher plant (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as california pitcher plant." + }, + { + "input": "Concept: Iridocapsular-fixation intraocular lens (Medical Device)", + "output": "something described as intraocular lenses, typically made of plastic, intended to be implanted and fixed to both the iris and to the posterior capsule of the eye, typically with a totally encircling loop. These lenses are implanted to replace the natural human lens following cataract removal." + }, + { + "input": "Concept: oxalyl coenzyme A decarboxylase activity (carboxy-lyase activity)", + "output": "carboxy-lyase activity described as catalysis of the reaction: H(+) + oxalyl-CoA = CO(2) + formyl-CoA." + }, + { + "input": "Concept: Agriculture, Organic (Occupational Activity)", + "output": "Occupational Activity described as systems of agriculture which adhere to nationally regulated standards that restrict the use of pesticides, non-organic fertilizers, genetic engineering, growth hormones, irradiation, antibiotics, and non-organic ANIMAL FEED." + }, + { + "input": "Concept: PedsQL Neuromuscular Module Acute Version 3.0 Parent of Toddler - Hands Are Weak (Intellectual Product)", + "output": "PedsQL Neuromuscular Module Acute Version 3.0 Parent of Toddler Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Acute Version 3.0 Parent of Toddler (PedsQL Neuromuscular Module Acute Version 3.0 Parent of Toddler) In the past 7 days, how much of a problem has this been for your child: My child's hands are weak." + }, + { + "input": "Concept: Fifth-Line Therapy (Line of Therapy)", + "output": "Line of Therapy described as treatment that is given when the first four treatments don't work, or stop working." + }, + { + "input": "Concept: Compounds, Allyl (Alkenes)", + "output": "Organic Chemical described as substance that consists of two or more chemical elements in union and containing the univalent organic group, -CH2 or allyl." + }, + { + "input": "Concept: Liver Fluke-Related Cholangiocarcinoma (Neoplastic Process)", + "output": "Cholangiocarcinoma described as a cholangiocarcinoma that has developed following infection with Opisthorchis viverrini." + }, + { + "input": "Concept: myeloid; sarcoma (Disorder of hematopoietic morphology)", + "output": "Leukemia, Myelocytic, Acute described as a malignant neoplasm composed of myeloblasts or immature myeloid cells. It occurs in extramedullary sites or the bone." + }, + { + "input": "Concept: 8p inverted duplication deletion syndrome (Disease or Syndrome)", + "output": "Anomaly of chromosome pair 8 described as a rare chromosomal anomaly with clinical manifestations of mild to severe intellectual deficit, severe developmental delay, hypotonia with tendency to develop progressive hypertonia over time, minor facial anomalies and agenesis of the corpus callosum. Thirty to fifty percent of individuals have autism. An inverted duplication with a terminal deletion of the short arm of chromosome 8 mostly occurs as either an inverted duplication from centromere to D8S552 with a pter deletion from D8S349 or as an inverted duplication from 8p11.2 or 8p21 to D8S552, with a telomeric deletion from D8349. The input of the 8p deletion to the clinical picture appears less significant than the 8p inversion duplication rearrangement. To date, all invdupdel(8p) have occurred de novo." + }, + { + "input": "Concept: organellar voltage gated chloride channel activity (voltage-gated chloride channel activity)", + "output": "voltage-gated chloride channel activity described as enables the transmembrane transfer of a chloride ion by a voltage-gated channel. The membrane is an organellar membrane." + }, + { + "input": "Concept: Stage I Ampulla of Vater Carcinoma AJCC v8 (Ampulla of Vater Cancer by AJCC v8 Stage)", + "output": "something described as stage I includes: IA: (T1a, N0, M0); IB: (T1b, N0, M0); (T2, N0, M0). T1a: Tumor limited to ampulla of Vater or sphincter of Oddi. T1b: Tumor invading beyond the sphincter of Oddi (perisphincteric invasion) and/or into the duodenal submucosa. T2: Tumor invading into the muscularis propria of the duodenum. N0: No regional lymph node metastasis. M0: No distant metastasis." + }, + { + "input": "Concept: Shipping fever (Other zoonotic bacterial diseases)", + "output": "Gram-Negative Bacterial Infections described as infections with bacteria of the genus PASTEURELLA." + }, + { + "input": "Concept: CRTAM Gene (Immunoprotein Gene)", + "output": "something described as this gene is involved in immune function." + }, + { + "input": "Concept: monoclonal antibody BC8, indium In 111 (Immunologic Factor)", + "output": "something described as a radioimmunoconjugate containing the murine IgG1 anti-CD45 monoclonal antibody (MoAb) BC8 labeled with the gamma-emitting isotope indium 111 (In 111), with potential radioimaging application. Upon administration, indium In 111 anti-CD45 monoclonal antibody BC8 binds to CD45 antigen, a receptor protein tyrosine phosphatase expressed on the surface of most of the normal and malignant hematopoietic cells. After binding and internalization by CD45-expressing tumor cells, radioactive In 111 allows for the detection of BC8 distribution and tumor localization using gamma scintigraphy." + }, + { + "input": "Concept: Polarity (chemical reactivity)", + "output": "Quantitative Concept described as the positive or negative direction of an electrical, acoustical, or magnetic force." + }, + { + "input": "Concept: Meropenem anhydrous (Monobactams)", + "output": "M [Preparations] described as the anhydrous form of meropenem, a broad-spectrum carbapenem with antibacterial properties, synthetic Meropenem inhibits cell wall synthesis in gram-positive and gram-negative bacteria. It penetrates cell walls and binds to penicillin-binding protein targets. Meropenem acts against aerobes and anaerobes including Klebsiella, E. coli, Enterococcus, Clostridium sp.." + }, + { + "input": "Concept: Capillary Action (Natural Phenomenon or Process)", + "output": "something described as a phenomenon in which the surface of a liquid where it contacts a solid is elevated or depressed, because of the relative attraction of the molecules of the liquid for each other and for those of the solid." + }, + { + "input": "Concept: BAALC, MEKK1 and KLF4 binding (Genes, Regulator)", + "output": "Gene or Genome described as this gene may be involved in neural and hematopoietic cell functions." + }, + { + "input": "Concept: EUTHYSCOPE, AC-POWERED (Medical Device)", + "output": "something described as a euthyscope is a device that is a modified battery-powered ophthalmoscope (a perforated mirror device used to inspect the interior of the eye) that projects a bright light encompassing an arc of about thirty degrees on the fundus of the eye. The center of the light bundle is blocked by a black disk covering the fovea (the central depression of the macular retinae where only cones are present and blood vessels are lacking). The device is intended for use in the treatment of amblyopia (dimness of vision without apparent disease of the eye)." + }, + { + "input": "Concept: Logical Observation Identifiers Names and Codes (Information Resources)", + "output": "Intellectual Product described as published by The Regenstrief Institute, the Logical Observation Identifiers Names and Codes covers clinical and clinical laboratory terminology." + }, + { + "input": "Concept: multi-peptide therapeutic vaccine 001 (Immunologic Factor)", + "output": "Pharmacologic Substance described as a synthetic peptide-based, personalized cancer vaccine consisting of multiple patient-specific tumor peptides, which are immunogenic and unique to the patient's tumor, combined with the immunostimulant polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose (poly-ICLC), with potential immunomodulating and antineoplastic activities. Upon vaccination with the personalized genomic vaccine 001 (PGV001), the peptides stimulate the host immune system to mount a specific and potent cytotoxic T-lymphocyte (CTL) response against tumor cells expressing the neoantigens, which results in tumor cell lysis. The adjuvant Poly-ICLC is added to boost the immune response to the peptides and together will expand immune cells to target cancer. The adjuvant poly-ICLC is a ligand for toll-like receptor-3 (TLR3) and induces the release of cytokines which may help to boost the immune response against the selected neoantigens. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C136466\" active clinical trials using this agent." + }, + { + "input": "Concept: proline racemase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the reaction: L-proline = D-proline." + }, + { + "input": "Concept: 12p11.1 (Cell Component)", + "output": "Chromosome band described as a chromosome band present on 12p" + }, + { + "input": "Concept: vibrational conductance of sound to the inner ear (Biologic Function)", + "output": "multicellular organismal process described as the transmission of vibrations via ossicles to the inner ear." + }, + { + "input": "Concept: anti-ErbB3/anti-IGF-1R bispecific monoclonal antibody MM-141 (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as a bispecific monoclonal antibody directed against the human epidermal growth factor receptor ErbB3 (Her3) and the human insulin-like growth factor-1 receptor (IGF-1R), with potential antineoplastic activity. The anti-IGF-1R targeting arm of anti-IGF-1R/anti-ErbB3 bispecific monoclonal antibody MM-141 binds to IGF-1R on tumor cells thereby preventing the binding of the natural ligands IGF-1, 2 and heregulin (HRG) to IGF-1R; the anti-ErbB3 therapeutic arm prevents the binding of neuregulin (NRG) to ErbB3. This prevents the activation of the PI3K/AKT signal transduction pathway and may result in both the induction of apoptosis and a decrease in cellular proliferation in IGF-1R and ErbB3-overexpressing tumor cells. IGF-1R, a receptor tyrosine kinase of the insulin receptor superfamily, and ErB3, a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, are frequently overexpressed in solid tumors. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C103863\" active clinical trials using this agent." + }, + { + "input": "Concept: Traditional Chinese Medicine Hou Gu Mi Xi (Traditional Chinese Medicine Formulation)", + "output": "Pharmacologic Substance described as an orally bioavailable dietary supplement and a formulation derived from the traditional Chinese medicine (TCM) Shen Ling Bai Zhu San, that can potentially be used to ameliorate spleen deficiency and improve symptoms of digestive disorders. Shen Ling Bai Zhu San is composed of ginseng, tuckahoe, atractylodes, baked licorice, coixenolide, Chinese yam, lotus seed, shrinkage fructus amomi, platycodon grandiflorum, white hyacinth bean, and dried orange peel. In Hou Gu Mi Xi, atractylodes and platycodon grandiflorum are removed from Shen Ling Bai Zhu San and perilla leaf is added. Upon oral administration, Hou Gu Mi Xi replenishes qi, and may improve spleen qi deficiency, gastrointestinal (GI) symptoms and GI function." + }, + { + "input": "Concept: principal sensory nucleus of trigeminal nerve development (Organ or Tissue Function)", + "output": "Organ or Tissue Function described as the process whose specific outcome is the progression of the pontine nucleus over time, from its formation to the mature structure." + }, + { + "input": "Concept: kidney anterior/posterior pattern formation (pattern specification involved in kidney development)", + "output": "anterior/posterior pattern specification described as the developmental process that results in the creation of defined areas or spaces within the kidney along the anterior/posterior axis to which cells respond and eventually are instructed to differentiate." + }, + { + "input": "Concept: simian virus (virus characteristic)", + "output": "something described as viruses that have been recovered from monkeys; they belong to many different groups, including adenoviruses, enteroviruses, herpesviruses, and reoviruses; see RTs for specific organisms." + }, + { + "input": "Concept: therapy, photodynamic (Clinical actions P - S)", + "output": "Physical therapy described as therapy using oral or topical photosensitizing agents with subsequent exposure to light." + }, + { + "input": "Concept: Echinocandin B, 1-((4R,5R)-4,5-dihydroxy-N2-(4-(octyloxy)benzoyl)-L-ornithine)- (Antifungal Agents)", + "output": "Pharmacologic Substance described as a narrow-spectrum cyclic lipopeptide derivative of echinocandin B derived from Aspergillus with fungicidal activity." + }, + { + "input": "Concept: Conceptual Imagery (Mental Process)", + "output": "Mental Process described as mental representation of concepts or conceptual relationships." + }, + { + "input": "Concept: nucleotide-excision repair, preincision complex (protein-DNA complex)", + "output": "Cell Component described as a multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage." + }, + { + "input": "Concept: DROPERIDOL (Anti-Anxiety Agents)", + "output": "Anti-Anxiety Agents described as a drug used to prevent nausea and vomiting in patients who receive anesthesia before surgery. It is also used to treat anxiety. Droperidol is a type of antiemetic, adjunct anesthesia, and antipsychotic." + }, + { + "input": "Concept: Acanthocheilonema, NOS (Filarioidea)", + "output": "Filarioidea described as a filarial nematode parasite of mammalian blood with the vector being a tick or small fly." + }, + { + "input": "Concept: Ulcer;duodenal (Ulceration of intestine)", + "output": "Diagnosis/Diseases Component described as an erosion of the mucous membrane in a portion of the duodenum." + }, + { + "input": "Concept: Region of wall of middle ear (Organ region cluster)", + "output": "something described as organ region cluster, each instance of which is a part of wall of some middle ear that is demarcated by either bona fide or fiat boundaries." + }, + { + "input": "Concept: Distal Bile Duct Cancer cM1 TNM Finding v7 (Finding)", + "output": "Distal Bile Duct Cancer Clinical Distant Metastasis TNM Finding v7 described as distal bile duct cancer with distant metastasis." + }, + { + "input": "Concept: nuclear polyadenylation-dependent CUT catabolic process (Genetic Function)", + "output": "Genetic Function described as the chemical reactions and pathways occurring in the nucleus and resulting in the breakdown of a cryptic unstable transcript (CUT), initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target CUT." + }, + { + "input": "Concept: Human Skin (Skin part)", + "output": "soft tissue described as tissue composed of three layers, epidermis, dermis and subcutis which protect underlying muscles and organs." + }, + { + "input": "Concept: Small miniature endplate potentials (Finding)", + "output": "Peripheral Nervous System described as an abnormal reduction in the amplitude of the miniature endplate potentials, i.e. the postsynaptic response to transmitter released from an individual vesicle at the neuromuscular junction." + }, + { + "input": "Concept: Interval (Temporal Concept)", + "output": "Temporal Concept described as the period of time or the distance separating two instances, events, or occurrences." + }, + { + "input": "Concept: Abdominal (Spatial Concept)", + "output": "Anatomy Qualifier described as having to do with the abdomen, which is the part of the body between the chest and the hips that contains the pancreas, stomach, intestines, liver, gallbladder, and other organs." + }, + { + "input": "Concept: singing (Individual Behavior)", + "output": "Individual Behavior described as use ANIMAL VOCALIZATIONS for singing in animal populations." + }, + { + "input": "Concept: PROSTHESIS, PENILE (Implants)", + "output": "Clinical appliance described as prostheses designed for implantation in the penis to provide penile tumescence and permit sexual contact. These prostheses may consist of inflatable tubes that are implanted in the penis and a liquid (e.g., saline with or without radiographic opacifiers) with appropriate abdominal implantable hydraulic components (e.g., conducts, pumps, reservoirs) to provide rigidity by applying pressure to the liquid or rigid or semirigid plastic bars that are implanted in the penis. Penile prostheses are intended for patients who suffer from erectile dysfunction." + }, + { + "input": "Concept: Increased plasma drug concentration (Abnormal drug response)", + "output": "something described as high plasma concentration of a drug as compared to previously measured thresholds given the expected concentration for the applied dosage regime." + }, + { + "input": "Concept: Pladienolide Derivative E7107 (Pharmacologic Substance)", + "output": "Organic Chemical described as a synthetic urethane derivative of pladienolide D with potential antineoplastic activity. Pladienolide derivative E7107 is generated from the 12-membered macrolide pladienolide D, one of several macrolides derived from the bacterium Streptomyces platensis Mer-11107. This agent appears to bind to the 130-kDa subunit 3 (spliceosome-associated protein 130; SAP130) of the splicing factor 3b (SF3b), resulting in inhibition of pre-messenger RNA splicing and the arrest of cell-cycle progression. The splicing factor SF3b is a multiprotein complex integral to the accurate excision of introns from pre-messenger RNA; the subunit SAP130 associates with U2 snRNP and is recruited to prespliceosomal complexes. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C69005\" active clinical trials using this agent." + }, + { + "input": "Concept: Exercisers, Muscle Strength, Lever/Pulley-Cable, Lower Limb, Leg Extension (Exercisers, Muscle Strength, Lever/Pulley-Cable, Lower Limb)", + "output": "something described as muscle strength exercisers designed to provide resistance to muscular contraction when the legs are extended against the resistance using a mechanism based on a system of pulleys and cables or levers. These exercisers usually consist of a stand-alone machine with weights stacked on top of each other or a hydraulic mechanism, a system to transmit the force (i.e., to convey the resistance), and lever bars or cables on which the user exerts force to counteract the exerciser resistance. Typically, users lift a padded lever bar with their ankles to extend the knees; less frequently, using the legs, the users pull the cables to extend their knees. Leg extension exercisers are intended to improve the strength of quadriceps muscles, increase muscle size, enhance muscle endurance and power, and improve bone density." + }, + { + "input": "Concept: dermatillomania (Obsessive-compulsive disorders and symptoms)", + "output": "Self-Injurious Behavior described as repetitive and compulsive picking of skin which results in tissue damage." + }, + { + "input": "Concept: cpng skls devment asistnce g (Therapeutic or Preventive Procedure)", + "output": "mental health counseling described as using group counseling techniques to assist clients in a group setting in developing their coping skills. Service is billed in 60-minute increments per client." + }, + { + "input": "Concept: Mixed Antigen IgE AB RAST Score (Immunoglobulin E measurement)", + "output": "Immunoglobulin E measurement described as a classification of the amount of mixed antigen IgE antibody, using the RAST (radioallergosorbent test) scoring system, in a biological specimen." + }, + { + "input": "Concept: Spontaneous Preterm Birth (Finding)", + "output": "Premature Birth described as preterm birth from 20 weeks to 36 weeks, 6 days of gestation associated with one of the following: classic preterm labor or preterm premature rupture of membranes." + }, + { + "input": "Concept: Recurrent Angioimmunoblastic T-Cell Lymphoma (Recurrent Mature T- Cell and NK-Cell Non-Hodgkin Lymphoma)", + "output": "Angioimmunoblastic Lymphadenopathy described as the reemergence of angioimmunoblastic T-cell lymphoma after a period of remission" + }, + { + "input": "Concept: VLA-2 complex (integrin complex)", + "output": "Cell Component described as an integrin complex that comprises one alpha2 subunit and one beta1 subunit." + }, + { + "input": "Concept: Fetal Female Sex Ratio (Quantitative Concept)", + "output": "something described as a measurement (expressed as a fraction or percent) of the number of live female fetuses to the total number of live male and female fetuses." + }, + { + "input": "Concept: positive regulation of phagosome maturation (regulation of phagosome maturation)", + "output": "positive regulation of organelle organization described as any process that activates or increases the frequency, rate or extent of phagosome maturation." + }, + { + "input": "Concept: stage IIIC ovarian epithelial cancer (Ovarian cancer stage III)", + "output": "Neoplastic Process described as ovarian cancer with macroscopic, extrapelvic, peritoneal metastasis greater than 2 cm +/- positive retroperitoneal lymph nodes. Includes extension to capsule of liver/spleen." + }, + { + "input": "Concept: Lateral Filing Cabinets (Cabinets, Filing)", + "output": "something described as filing cabinets designed to store files and/or file folders upright and perpendicular to the front of the cabinet (i.e., lateral filing). These cabinets typically consist of a metallic or wooden stand-alone structure, including one or more drawers that can accommodate letter-, A4-, and/or legal-size documents; they may include side-to-side rails to hang file folders. Lateral filing cabinets frequently include locking systems and/or mechanisms that allow only one drawer to open at a time to avoid tipping; they are available in many different configurations and sizes." + }, + { + "input": "Concept: PODCI1-Open a Jar Been Opened Before (PODCI Pediatric Parent-Reported Version Questionnaire Question)", + "output": "something described as pediatric Outcomes Data Collection Instrument, Pediatric Parent-Reported Version (PODCI Pediatric Parent-Reported Version) During the last week, was it easy or hard for your child to: Open a jar that has been opened before?" + }, + { + "input": "Concept: PROT-SPURPRS (CDISC Protocol Terminology)", + "output": "something described as terminology associated with the study purpose response codelist of the Clinical Data Interchange Standards Consortium (CDISC) protocol entities." + }, + { + "input": "Concept: Colposcope (Obstetrical/gynecological device)", + "output": "Obstetrical/gynecological device described as a lighted magnifying instrument used to examine the vagina and cervix." + }, + { + "input": "Concept: MUSCULOSKELETAL SYSTEM (Finding)", + "output": "something described as symptoms, physical examination results, and/or laboratory test results related to the musculoskeletal system, also including connective and soft tissue." + }, + { + "input": "Concept: Stools, Adjustable, Anesthesiology (Anesthesia and respiratory device)", + "output": "Anesthesia and respiratory device described as an anesthesia stool is a device intended for use as a stool for the anesthesiologist in the operating room." + }, + { + "input": "Concept: Tumor Promotion (Neoplastic Cell Transformation)", + "output": "something described as a process in which existing tumors are stimulated to grow. Tumor promoters are not able to cause tumors to form." + }, + { + "input": "Concept: S100-A7 Protein Measurement (Protein or Enzyme Type Measurement)", + "output": "Laboratory Procedure described as the determination of the amount of S100 calcium binding protein A7 protein present in a sample." + }, + { + "input": "Concept: signal transduction involved in DNA damage checkpoint (Cell Function)", + "output": "something described as a signal transduction process that contributes to a DNA damage checkpoint." + }, + { + "input": "Concept: Lobectomy, Anterior Temporal (Operative Surgical Procedures)", + "output": "Neurosurgical Procedures described as a neurosurgical procedure that removes the anterior TEMPORAL LOBE including the medial temporal structures of CEREBRAL CORTEX; AMYGDALA; HIPPOCAMPUS; and the adjacent PARAHIPPOCAMPAL GYRUS. This procedure is generally used for the treatment of intractable temporal epilepsy (EPILEPSY, TEMPORAL LOBE)." + }, + { + "input": "Concept: WHOLE EXOME SEQUENCING (Whole Genome Sequencing)", + "output": "Large-Scale Sequencing described as techniques to determine the complete complement of sequences of all EXONS of an organism or individual." + }, + { + "input": "Concept: Grade 1 Retinoic Acid Syndrome, CTCAE (Finding)", + "output": "Retinoic Acid Syndrome, CTCAE described as fluid retention; <3 kg of weight gain; intervention with fluid restriction and/or diuretics indicated" + }, + { + "input": "Concept: upregulation of aortic smooth muscle cell differentiation (positive regulation of vascular smooth muscle cell differentiation)", + "output": "regulation of aortic smooth muscle cell differentiation described as any process that activates or increases the frequency, rate or extent of aortic smooth muscle cell differentiation." + }, + { + "input": "Concept: Non-Sporting Breed (Dog Breed)", + "output": "something described as an exceptionally diverse group of dogs with varying sizes, coats, personalities that come from a wide variety of backgrounds. Generally they make good watchdogs and housedogs." + }, + { + "input": "Concept: Oromucosal ointment (Oromucosal Dosage Form)", + "output": "Oromucosal Dosage Form described as semi-solid multidose preparation consisting of an ointment intended for oromucosal use. It is applied to the oral cavity or onto a specific part of the oral cavity, to obtain a local effect" + }, + { + "input": "Concept: CT scan abdomen with contrast (Diagnostic radiography with contrast media)", + "output": "CT of abdomen described as computed tomography of the abdomen with the use of a contrast agent to enhance the image." + }, + { + "input": "Concept: EOR01-Difficulty Concentrating on Things (EORTC QLQ-C30 Version 3 Questionnaire Question)", + "output": "something described as european Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire - Core 30 Version 3.0 (EORTC QLQ-C30 Version 3) During the past week: Have you had difficulty in concentrating on things, like reading a newspaper or watching television?" + }, + { + "input": "Concept: Colorectal Cancer pN2a TNM Finding v7 (Finding)", + "output": "something described as colorectal cancer with metastasis in 4-6 regional lymph nodes." + }, + { + "input": "Concept: Autologous EBV-CTL CD19CAR zeta (Chimeric Antigen Receptor T-cells)", + "output": "therapeutic autologous lymphocytes described as autologous Epstein-Barr virus (EBV)-specific cytotoxic T-lymphocytes (CTL) that have been genetically modified to express a T-cell chimeric antigen receptor (CAR) targeting the CD19 antigen, with potential immunotherapeutic activity. The CAR consists of a single chain Fv of anti-CD19 IgG1 coupled with an intracellular signaling region of the zeta-chain of the TCR/CD3 complex (CD3 zeta). Autologous EBV-CTL CD19CAR zeta directs the T-lymphocytes to CD19-expressing tumor cells, stimulating a selective toxicity to tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C78824\" active clinical trials using this agent." + }, + { + "input": "Concept: Stage IV Ovarian Germ Cell Tumor AJCC v7 (Malignant Ovarian Germ Cell Neoplasm)", + "output": "Neoplastic Process described as cancer is found in one or both ovaries and has metastasized (spread) beyond the abdomen to other parts of the body. Cancer that has spread to tissues in the liver is considered stage IV disease." + }, + { + "input": "Concept: T-Cell Prolymphocytic Leukemia, Small Cell Variant (T-Cell Prolymphocytic Leukemia)", + "output": "Neoplastic Process described as a T-cell prolymphocytic leukemia characterized by the presence of small neoplastic prolymphocytes often with invisible nucleolus by light microscopy." + }, + { + "input": "Concept: Grade 5 Infantile Apnea, AE (Finding)", + "output": "Finding described as death." + }, + { + "input": "Concept: Central Midwest States (Geographic Area)", + "output": "something described as the area in the United States comprised of the following states: Illinois, Missouri, Kansas and Nebraska." + }, + { + "input": "Concept: CYCLACILLIN (Aminopenicillin)", + "output": "Antibiotic described as a cyclohexylamido analog of PENICILLANIC ACID." + }, + { + "input": "Concept: AVL01114 (ADNI-AVLT Questionnaire Question)", + "output": "Intellectual Product described as alzheimer's Disease Neuroimaging Initiative Auditory Verbal Learning Test Version A (ADNI-AVLT Version A) List B, Word 12." + }, + { + "input": "Concept: Periostitis, NOS (Bone disorders NEC)", + "output": "Bone Diseases, Infectious described as inflammation of the periosteum. The condition is generally chronic, and is marked by tenderness and swelling of the bone and an aching pain. Acute periostitis is due to infection, is characterized by diffuse suppuration, severe pain, and constitutional symptoms, and usually results in necrosis." + }, + { + "input": "Concept: dorsal vertebra (Structure of musculoskeletal system of thoracic spine)", + "output": "Bone structure of spine described as a group of twelve VERTEBRAE connected to the ribs that support the upper trunk region." + }, + { + "input": "Concept: Diaphanographies (Miscellaneous diagnostic tests)", + "output": "Imaging Techniques described as examination of a body part by transillumination." + }, + { + "input": "Concept: Childhood Clear Cell Sarcoma of Soft Tissue (Childhood Soft Tissue Sarcoma)", + "output": "Neoplastic Process described as a clear cell sarcoma of soft tissue occurring in children." + }, + { + "input": "Concept: tyrosine kinase inhibitor (Pharmacologic Substance)", + "output": "Epidermal growth factor receptor inhibitor described as any substance that inhibits tyrosine kinase, an enzyme involved in the transduction and processing of many extracellular and intracellular signals including cell proliferation. Inhibition of tyrosine kinase may result in inhibition of cell growth and cell proliferation." + }, + { + "input": "Concept: Enterochromaffin cell (Cell)", + "output": "Endo-epithelial cell described as endocrine cell of the gut" + }, + { + "input": "Concept: PQL1520 (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Child Questionnaire Question)", + "output": "PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Child Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Acute Version 3.0 Parent Report for Child (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Child) In the past 7 days, how much of a problem has this been for your child: It is hard for my child to explain his or her illness to other people." + }, + { + "input": "Concept: RASVAC-C (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as a synthetic vaccine used for cancer immunotherapy also known as Ras(cis 12)-Vaccinia Vaccine, RASVAC-C is based on a mutant peptide epitope of the Ras oncoprotein at codon 12 that induces recognition and induction of tumor-specific, cell-mediated immune responses. Ras is an intracellular GTP-binding protein involved in signal transduction and regulation of proliferation and differentiation." + }, + { + "input": "Concept: Transferring oneself while sitting (Physiologic Function)", + "output": "something described as moving from a sitting position on one seat to another seat on the same or a different level, such as moving from a chair to a bed." + }, + { + "input": "Concept: modulation of host small GTPase mediated signal transduction by symbiont (modulation by symbiont of host signal transduction pathway)", + "output": "something described as any process in which a symbiont organism modulates the frequency, rate or extent of small GTPase mediated signal transduction in its host organism." + }, + { + "input": "Concept: Spectrin (Biologically Active Substance)", + "output": "Cytoskeletal Proteins described as a high molecular weight (220-250 kDa) water-soluble protein which can be extracted from erythrocyte ghosts in low ionic strength buffers. The protein contains no lipids or carbohydrates, is the predominant species of peripheral erythrocyte membrane proteins, and exists as a fibrous coating on the inner, cytoplasmic surface of the membrane." + }, + { + "input": "Concept: Childhood-onset autosomal recessive myopathy with external ophthalmoplegia (Chronic progressive external ophthalmoplegia)", + "output": "Chronic nervous system disorder described as a rare genetic non-dystrophic myopathy disease with characteristics of childhood-onset severe external ophthalmoplegia, typically without ptosis, associated with mild, very slowly progressive muscular weakness and atrophy, involving the facial, neck flexor and limb muscles. Muscle biopsy shows type 1 fiber uniformity, absent or abnormally small type 2A fibers, increased variability of fiber size, internalized nuclei and/or fatty infiltration." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Serology, Calibration, Virus (Medical Device)", + "output": "IVD Test Reagent/Kits, Serology, Calibration described as reagents consisting of substances intended to establish points of reference (i.e., calibrate). They are used in serologic tests performed for the determination of antigens and/or antibodies that cause infectious diseases in human specimens due to a pathogenic virus." + }, + { + "input": "Concept: Appendiceal Cancer TNM Finding v7 (Finding)", + "output": "something described as a finding about one or more characteristics of appendiceal cancer, following the rules of the TNM AJCC v7 classification system. Carcinomas and carcinoid tumors of the appendix are included, but are separately categorized." + }, + { + "input": "Concept: atrial septal defect (Congenital Abnormality)", + "output": "Abnormality of atrial septum described as developmental abnormalities in any portion of the ATRIAL SEPTUM resulting in abnormal communications between the two upper chambers of the heart. Classification of atrial septal defects is based on location of the communication and types of incomplete fusion of atrial septa with the ENDOCARDIAL CUSHIONS in the fetal heart. They include ostium primum, ostium secundum, sinus venosus, and coronary sinus defects." + }, + { + "input": "Concept: UIG (Turkic language)", + "output": "something described as a Turkic language spoken primarily by the Uyghur people in the Xinjiang Uyghur Autonomous Region of Western China." + }, + { + "input": "Concept: cavity chest (Anterior thoracic region)", + "output": "Structure of thorax, including mediastinum and diaphragm described as the region of the thorax that includes the PLEURAL CAVITY and MEDIASTINUM." + }, + { + "input": "Concept: Incomplete ossification of palatine bone (Congenital anomaly of palatine bone)", + "output": "Defect of skull ossification described as failure to complete ossification (maturation and calcification) of the palatine bone." + }, + { + "input": "Concept: Compliance with Diet (Health Care Activity)", + "output": "Health Care Activity described as actions performed to encourage adherence to diet/food intake" + }, + { + "input": "Concept: Thyro-hyoid Membrane (Body Part, Organ, or Organ Component)", + "output": "Structure of ligament of neck described as a broad, fibro-elastic membrane extending from the upper border of the thyroid cartilage to the greater cornu and posterior border of the hyoid bone." + }, + { + "input": "Concept: mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis (Organism Function)", + "output": "mesenchymal stem cell maintenance involved in nephron morphogenesis described as the process in which an organism retains a population of mesenchymal stem cells that contributes to the shaping of a nephron in the metanephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells." + }, + { + "input": "Concept: Global Alignment of Immunization safety Assessment in pregnancy Level 1 Intrapartum Stillbirth (Intellectual Product)", + "output": "something described as level 1 Intrapartum Stillbirth is defined by four criteria: first, delivery of an infant with no of signs of life at birth, including the following: no spontaneous movements, no umbilical cord pulse, no heartbeat, no respirations, and an Apgar score of 0 at both 1 and 5 minutes. Determination of the absence of signs of life is made by physical examination after delivery, with or without electronic monitoring of heart rate, respiratory rate, and pulse oximetry; second, evidence of a live fetus prior to the onset of labor (confirmed by documentation of fetal movement and of fetal heart tones by ultrasound prior to onset of labor). NOTE: In the absence of evidence of a live fetus prior to the onset of labor, the fetal death should be reported as a stillbirth or an antepartum stillbirth; third, attended delivery followed by post-delivery physical examination by an obstetrician, a neonatologist, a paediatrician, a maternal-fetal medicine specialist, or a pathologist that is consistent with intrapartum death. In a setting where access to a specialist is not feasible, diagnosis by a health care provider trained or experienced to make the diagnosis is acceptable (e.g. general practice physician, mid-wife, or other qualified trained practitioner); fourth, gestational age within the pre-defined range for selected stillbirth definition as assessed by maternal and/or fetal-neonatal parameters (level 1 in GA assessment algorithm)." + }, + { + "input": "Concept: Metastatic Salivary Gland Carcinoma (Head and neck cancer metastatic)", + "output": "Neoplastic Process described as a salivary gland carcinoma that has metastasized to another anatomic site." + }, + { + "input": "Concept: EMO1-Happiness Responded as Fear (ERT Functional Test Question)", + "output": "ERT Functional Test Question described as emotion Recognition Test (ERT) Number of happiness stimuli responded to as fear." + }, + { + "input": "Concept: Dextranase (Hydrolase)", + "output": "something described as enzyme that hydrolyzes DEXTRAN to OLIGOSACCHARIDES." + }, + { + "input": "Concept: failure ejaculation (Genital Diseases, Male)", + "output": "reproductive system disorder described as inability to ejaculate." + }, + { + "input": "Concept: yCi (Unit of radioactivity)", + "output": "Unit of radioactivity described as a unit of radioactivity defined as 3.7E-14 atomic disintegrations or other nuclear transformations per second or one septillionth of curie (10E-24 curie)." + }, + { + "input": "Concept: Performed Clinical Interpretation Abnormal Indicator (Abnormal Indicator)", + "output": "Abnormal Indicator described as specifies whether an interpreted event is abnormal. EXAMPLE(S): OTHER NAME(S): NOTE(S): Derived from PerformedClinicalInterpretation.value(ANY=>CD).code WHERE PerformedObservationResult.typeCode = \"assess abnormality\"." + }, + { + "input": "Concept: PtdIns(3,5)P2 binding (Molecular Function)", + "output": "Molecular Function described as interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions." + }, + { + "input": "Concept: Anti-Delta-Like 4 Monoclonal Antibody REGN421 (Pharmacologic Substance)", + "output": "Immunologic Factor described as a human monoclonal antibody directed against Delta-like ligand-4 (DLL4) with potential antineoplastic activity. Anti-DLL4 monoclonal antibody REGN421 specifically binds to human DLL4, preventing its binding to Notch receptors and inhibiting Notch signaling, which may result in defective tumor vascularization and, so, the inhibition of tumor cell growth. DLL4 is the only Notch ligand selectively expressed on endothelial cells; DLL4/Notch signaling is required for the development of functional tumor blood vessels. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C82367\" active clinical trials using this agent." + }, + { + "input": "Concept: Classes, Childbirth (Health Care Activity)", + "output": "Health Care Activity described as preparing parents-to-be for CHILDBIRTH." + }, + { + "input": "Concept: Spine Cancer pTX TNM Finding v8 (Spine Cancer Pathologic Primary Tumor TNM Finding v8)", + "output": "something described as spine cancer in which the primary tumor cannot be assessed." + }, + { + "input": "Concept: cAMP-dependent protein kinase, type 2alpha-regulatory subunit, human (Enzyme)", + "output": "Regulatory Protein described as cAMP-dependent protein kinase type II-alpha regulatory subunit (404 aa, ~46 kDa) is encoded by the human PRKAR2A gene. This protein is involved in the positive regulation of cyclic AMP-dependent signaling." + }, + { + "input": "Concept: Colorectal Cancer cM0 TNM Finding v7 (Finding)", + "output": "something described as colorectal cancer without evidence of distant metastasis." + }, + { + "input": "Concept: UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase activity (catalytic activity, acting on a glycoprotein)", + "output": "something described as catalysis of the reaction: N-acetyl-D-galactosalaminyl-R + UDP-N-acetyl-D-glucosamine = N-acetyl-beta-D-glucosaminyl-1,3-N-acetyl-D-galactosaminyl-R + UDP." + }, + { + "input": "Concept: cholecystokinin (Peptides)", + "output": "Gastrointestinal Hormones described as hormone secreted by upper intestinal mucosa on contact with gastric contents, cholecystokini; stimulates contraction of the gallbladder. Also, a neurotransmitter." + }, + { + "input": "Concept: Temporoparietal aphasia (Mental or Behavioral Dysfunction)", + "output": "something described as impairment in the comprehension of speech and meaning of words, both spoken and written, and of the meanings conveyed by their grammatical relationships in sentences. It is caused by lesions that primarily affect Wernicke's area, which lies in the posterior perisylvian region of the temporal lobe of the dominant hemisphere." + }, + { + "input": "Concept: IFNW1 wt Allele (IFNW1 gene)", + "output": "something described as human IFNW1 wild-type allele is located in the vicinity of 9p22 and is approximately 2 kb in length. This allele, which encodes interferon omega-1 protein, plays a role in intracellular signal transduction pathway progression in response to viral invasion." + }, + { + "input": "Concept: DNA Sequencing Systems (Medical Device)", + "output": "Nucleic Acid Processors described as nucleic acid processors designed for the automated determination of the precise sequence of the base pairs (i.e., adenine, thymine, cytosine, and guanine for DNA) in a sample of nucleic acid. These devices typically process samples of DNA molecules (labeled with multiple fluorescent dyes) that are loaded onto a gel. Usually, the samples are separated by size using capillary electrophoresis; samples are illuminated and detected using a scanning laser beam, and the results are processed using computer analysis. Electrophoretic separation can be displayed in real time; the sequence of nucleotides for the whole sample (e.g., read lengths as long as several hundred base pairs) is printed after computerized ordering." + }, + { + "input": "Concept: Eccrine mixed tumour (Primary malignant neoplasm of sweat gland)", + "output": "Benign skin tumor with eccrine differentiation described as a rare, benign, slow-growing and painless neoplasm of sweat glands. It usually arises in the head and neck. It is characterized by the presence of a mesenchymal chondroid stroma, fibrosis, and epithelial structures." + }, + { + "input": "Concept: WRIGHT-GIEMSA STAIN (Routine Histology Staining Method)", + "output": "Routine Histology Staining Method described as geimsa is a polychromatic stain that permits the differentiation of cells present in hematopoietic tissues and for the demonstration of certain microorganisms. It is used for the detection of helicobacter pylori. The H. pylori and nuclei stain dark blue and cytoplasm stain pink with this stain (From BioGenex)." + }, + { + "input": "Concept: Immortalized (Molecular Genetic Technique)", + "output": "something described as laboratory methods used to generate cells that are able to reproduce indefinitely." + }, + { + "input": "Concept: AdverseEvent.expectedIndicator (Qualitative Concept)", + "output": "something described as specifies whether the specificity (nature), frequency, or severity of an adverse event is consistent with the applicable study documentation (e.g., investigator's brochure, protocol document, or consent document) or product labeling (package insert)." + }, + { + "input": "Concept: Non-Clinical Pairing Trial Phase (Temporal Concept)", + "output": "Temporal Concept described as the period of time in a non-clinical study from the start of cohabitation until evidence of mating is observed and/or the subjects are separated." + }, + { + "input": "Concept: Bactrocera (Dacini)", + "output": "Eukaryote described as genus in the family TEPHRITIDAE that includes the Queensland fruit fly Bactrocera tyroni." + }, + { + "input": "Concept: syndrome; dyspraxia (Developmental Coordination Disorder)", + "output": "Neurobehavioral Manifestations described as a defect in the understanding of complex motor commands and in the execution of certain learned movements, i.e., deficits in the cognitive components of learned movements." + }, + { + "input": "Concept: Newborn drug withdrawal syndr. (Disease or Syndrome)", + "output": "something described as a constellation of neurobehavioral features observed in a neonate following antenatal exposure to drugs including opioids, benzodiazepines, and selective serotonin reuptake inhibitors." + }, + { + "input": "Concept: Pressure, Maximum Expiratory (Diagnostic Procedure)", + "output": "something described as the maximum amount of pressure applied to the lungs during expiration." + }, + { + "input": "Concept: Phenytoin product (Sodium channel blocker-containing product)", + "output": "phenytoin described as a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux from neurons located in the motor cortex reducing post-tetanic potentiation at synapses. The reduction of potentiation prevents cortical seizure foci spreading to adjacent areas, stabilizing the threshold against hyperexcitability. In addition, this agent appears to reduce sensitivity of muscle spindles to stretch causing muscle relaxation." + }, + { + "input": "Concept: acids nucleic (Organic Chemicals)", + "output": "Biologically Active Substance described as naturally occurring or synthetic polynucleotides; DNA or RNA." + }, + { + "input": "Concept: Progenitor B-Cells (Cell)", + "output": "something described as cells from the stage of B LYMPHOCYTE development where B-CELL GENE REARRANGEMENT begins. The pro-B cell stage is followed by the pre-B cell stage." + }, + { + "input": "Concept: up-regulation of orcinol biosynthetic process (regulation of orcinol biosynthetic process)", + "output": "Molecular Function described as any process that activates or increases the frequency, rate or extent of orcinol biosynthetic process." + }, + { + "input": "Concept: LGALS3 (Binding Proteins)", + "output": "something described as a multifunctional galactin initially discovered as a macrophage antigen that binds to IMMUNOGLOBULIN E, and as 29-35-kDa lectin that binds LAMININ. It is involved in a variety of biological events including interactions with galactose-containing glycoconjugates, cell proliferation, CELL DIFFERENTIATION, and APOPTOSIS." + }, + { + "input": "Concept: age-dependent response to ROI (age-dependent response to oxidative stress)", + "output": "age-dependent response to oxidative stress described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." + }, + { + "input": "Concept: SAK, Mouse, Homolog of Gene (PLK4 gene)", + "output": "something described as human PLK4 wild-type allele is located in the vicinity of 4q28 and is approximately 18 kb in length. This allele, which encodes serine/threonine-protein kinase PLK4 protein, is involved in centriole duplication." + }, + { + "input": "Concept: metanephric long descending thin limb development (metanephric nephron epithelium development)", + "output": "long descending thin limb development described as the process whose specific outcome is the progression of the metanephric long descending thin limb over time, from its formation to the mature structure. The metanephric long descending thin limb is the descending thin limb of a long nephron in the metanephros that has a squamous epithelial morphology. The long descending limb starts in the inner stripe of the outer medulla and extends into the inner medulla." + }, + { + "input": "Concept: Reviewable Unit Type Code (Type Code)", + "output": "Type Code described as a coded value specifying the kind of reviewable unit. EXAMPLE(S): toxicology, safety, manufacturing, administrative" + }, + { + "input": "Concept: Servers, Computer Network (Computer equipment)", + "output": "Radiographic unit described as a computer that controls a central repository of data, files, and/ or applications that can be accessed and/or manipulated in some manner by client computers. NOTE: A file server hosts files for use by client machines. A web server supports browser-based use of central applications." + }, + { + "input": "Concept: Colorectal Cancer Gene Methylation Panel Reagents (Medical Device)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Epigenetic Modification, DNA Methylation, Panel described as molecular assay reagents intended for use in detecting DNA methylation at multiple genetic loci (i.e., genes) which has a methylation status (e.g., hypomethylation, hypermethylation) associated with colorectal cancer. Assessment of the methylation status of certain genes may be used as an aid in detecting the presence of colorectal cancer or in assessing the aggressiveness of colorectal cancer." + }, + { + "input": "Concept: gastrulation with mouth forming first (Gastrulation)", + "output": "something described as a gastrulation process in which the initial invagination becomes the mouth and the anus forms second." + }, + { + "input": "Concept: Non-Neoplastic Hematologic and Lymphocytic Disorder (Hematological Disease)", + "output": "Disease or Syndrome described as a disorder that arises from the bone marrow or lymphoid system and is characterized by the absence of a clonal cellular component. It rarely progresses to a malignant neoplasm." + }, + { + "input": "Concept: Follicles (Hair Part)", + "output": "Subdivision of epidermis described as a shaft or opening on the surface of the skin through which hair grows." + }, + { + "input": "Concept: AONC (Biomedical Occupation or Discipline)", + "output": "Advanced Practice Nurse described as a registered nurse who has worked at least 12 months out of the last 3 years as an oncology nurse. The nurse must also have worked at least 1,000 hours out of the last 2-1/2 years in the field of oncology." + }, + { + "input": "Concept: ob/ob (Mice, Inbred Strains)", + "output": "Mice, Inbred Strains described as the obese mutant mouse was derived from a spontaneous mutation in a V/Le progenitor mouse at the Jackson Laboratory in 1949." + }, + { + "input": "Concept: Crypts of Lieberkuhn (Simple tubular gland)", + "output": "Intestinal Mucosa described as denotes the pits or crypts, but not the glands that lie beneath them" + }, + { + "input": "Concept: Ultrasound-Guided Transbronchial Needle Aspiration (Therapeutic or Preventive Procedure)", + "output": "something described as the use of ultrasound imaging to guide needle aspiration through the bronchial wall." + }, + { + "input": "Concept: IOP increased (Asymmetry of intraocular pressure)", + "output": "Ophthalmic function diagnostic procedures described as intraocular pressure that is 2 standard deviations above the population mean. []" + }, + { + "input": "Concept: TRIM Family (Biologically Active Substance)", + "output": "Biologically Active Substance described as genes belonging to this family are implicated in several inherited human diseases (Familial Mediterranean Fever, X-linked Opitz/GBBB syndrome, and Mulibrey nanism) and in tumorigenesis. The TRIM proteins have a strong self-association ability that is mediated by their coiled-coil region. This property results in the formation of large protein complexes that identify diverse discrete sub-cellular structures. The formation of these cellular compartments is strictly dependent on the integrity of the Tripartite Motif. The TRIM proteins might play a role in cell sub-compartmentalization." + }, + { + "input": "Concept: Woringer-Kolopp Disease (mycosis fungoides of skin)", + "output": "something described as a distinct variant of mycosis fungoides characterized by the presence of localized patches or plaques with an intraepidermal proliferation of neoplastic cells." + }, + { + "input": "Concept: LMB-9 immunotoxin (Pharmacologic Substance)", + "output": "Immunologic Factor described as a recombinant disulfide stabilized anti-Lewis Y IgG immunotoxin containing a 38 KD toxic element derived from the Pseudomonas aeruginosa exotoxin A and a monoclonal antibody fragment, designed to target adenocarcinomas expressing Lewis Y. LMB-9 immunotoxin attaches to tumor cells, facilitating he entry of the exotoxin. The exotoxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2472\" active clinical trials using this agent." + }, + { + "input": "Concept: Ovarian ablation (Procedure on ovary)", + "output": "Therapeutic or Preventive Procedure described as surgery, radiation therapy, or a drug treatment to stop the functioning of the ovaries." + }, + { + "input": "Concept: positive regulation of mitochondrion organisation (regulation of mitochondrion organization)", + "output": "Cell Function described as any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." + }, + { + "input": "Concept: APCH106B (Intellectual Product)", + "output": "something described as acute Physiology and Chronic Health Evaluation II - Serum HCO3 (venous mMol/L) (Not preferred, use if no ABGs)." + }, + { + "input": "Concept: Secretin porcine (gastric juice inhibitor)", + "output": "Hormone described as a peptide hormone of about 27 amino acids from the duodenal mucosa that activates pancreatic secretion and lowers the blood sugar level." + }, + { + "input": "Concept: BAY 1143269 (Serine/Threonine Kinase Inhibitor)", + "output": "Organic Chemical described as an orally bioavailable inhibitor of mitogen-activated protein kinase interacting serine/threonine-protein kinase 1 (MKNK1), with potential antineoplastic activity. Upon oral administration, MKNK1 inhibitor BAY 1143269 binds to MKNK1, thereby preventing its activation and the downstream MKNK1-mediated phosphorylation and activation of eukaryotic translation initiation factor 4E (eIF4E). As eIF4E enhances the synthesis of oncogenic proteins, preventing eIF4E activity inhibits the synthesis of tumor angiogenic factors and leads to both the inhibition of cellular proliferation and apoptosis in susceptible tumor cells. eIF4E, overexpressed in a variety of cancer cells, plays a key role in tumor cell proliferation and survival." + }, + { + "input": "Concept: Estimation (Thesaurus of Psychological Index Terms)", + "output": "Mental Process described as subjective judgment or inference about the character, quality, or nature of a person, process, or thing which may or may not involve the inspection or availability of data or pertinent information." + }, + { + "input": "Concept: Poorly ossified cervical vertebrae (Poorly ossified vertebrae)", + "output": "Poorly ossified vertebrae described as decreased ossification of the cervical vertebral bodies, i.e., of the Cervical vertebrae set." + }, + { + "input": "Concept: R360115 (RAND-36 Questionnaire Question)", + "output": "something described as RAND 36-Item Health Survey 1.0 (RAND-36) During the past 4 weeks, have you had any of the following problems with your work or other regular daily activities as a result of your physical health: Were limited in the kind of work or other activities." + }, + { + "input": "Concept: Transcription factor HMX3, human (Transcription Regulatory Protein)", + "output": "Amino Acid, Peptide, or Protein described as proline-, glutamic acid- and leucine-rich protein 1 (1130 aa, ~120 kDa) is encoded by the human PELP1 gene. This protein is involved in steroid receptor-dependent transcription." + }, + { + "input": "Concept: Rosa x centifolia (Oils, Volatile)", + "output": "Oils, Volatile described as moroccan rose." + }, + { + "input": "Concept: Immunoenzyme Procedure (Immunologic Tests)", + "output": "something described as an immunological procedure involving the usage of enzyme-antibody or enzyme-antigen conjugates, antienzyme antibodies, or enzyme-antienzyme complexes." + }, + { + "input": "Concept: FAC01603 (Intellectual Product)", + "output": "FACT-L Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Lung Version 4 (FACT-L Version 4) Physical Well-Being: Because of my physical condition, I have trouble meeting the needs of my family." + }, + { + "input": "Concept: SERPINA9 (Proteinase Inhibitor Gene)", + "output": "Proteinase Inhibitor Gene described as this gene is involved in trypsin activity regulation." + }, + { + "input": "Concept: Primary unilateral adrenal hyperplasia (Disease or Syndrome)", + "output": "Adrenal hyperplasia described as a surgically correctable form of primary hyperaldosteronism characterised by renin suppression, unilateral aldosterone hypersecretion, and moderate to severe hypertension secondary to hyperplasia of the adrenal gland. May be associated with hypokalaemia, which, when present, may be symptomatic with muscular weakness, cramps, paresthesia or palpitations with or without atrial fibrillation.The aetiology is not known. Unilateral adrenalectomy abolishes aldosterone hypersecretion and hypokalaemia in most patients." + }, + { + "input": "Concept: therapist attitudes (Counselor Characteristics)", + "output": "Counselor Characteristics described as attitudes of, not toward, therapists." + }, + { + "input": "Concept: Blindness, Pure Word (Dyslexia, Acquired)", + "output": "Mental or Behavioral Dysfunction described as loss of the power to comprehend written materials despite preservation of the ability to write (i.e., alexia without agraphia). This condition is generally attributed to lesions that \"disconnect\" the visual cortex of the non-dominant hemisphere from language centers in the dominant hemisphere. This may occur when a dominant visual cortex injury is combined with underlying white matter lesions that involve crossing fibers from the occipital lobe of the opposite hemisphere." + }, + { + "input": "Concept: Electrical Dermatomes (Dermatome device)", + "output": "Medical Device described as dermatomes designed to harvest large, uniform-thickness skin grafts using electric power. These dermatomes are typically handheld instruments that include an electric powered rapidly oscillating cutting blade that is manually advanced over the skin. Several dedicated electric dermatomes using this operating principle are available (e.g., Castroviejo, Reese, Padgett-Hood, Brown, Davol-Simon, Zimmer). Electric dermatomes are mainly used to obtain skin grafts from donor sites, but are sometimes used in other procedures (e.g., to remove tattoos)." + }, + { + "input": "Concept: ATP sulfurylase activity (sulfate adenylyltransferase activity)", + "output": "sulfate adenylyltransferase activity described as catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate." + }, + { + "input": "Concept: Renal medullary pyramid hypoplasia (Congenital Abnormality)", + "output": "something described as undergrowth of the pyramid of the adult kidney, cone-shaped structures with a broad base adjacent to the renal cortex and the narrow apex that is termed papilla." + }, + { + "input": "Concept: Between brain (Brain part)", + "output": "Cerebrum described as the paired caudal parts of the PROSENCEPHALON from which the THALAMUS; HYPOTHALAMUS; EPITHALAMUS; and SUBTHALAMUS are derived." + }, + { + "input": "Concept: FDATCHSP (Intellectual Product)", + "output": "Intellectual Product described as the name and version of the FDA technical specification that is being used in the study submission." + }, + { + "input": "Concept: type I DNA topoisomerase activity (DNA topoisomerase activity)", + "output": "DNA topoisomerase activity described as catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." + }, + { + "input": "Concept: Multiple Myeloma-Light Chain Only (Finding)", + "output": "something described as only the light chain (kappa or lambda) of the immunoglobulin is defective." + }, + { + "input": "Concept: Investigator Role in Study (Research Personnel)", + "output": "Classification described as the characteristic that defines the responsibility of the investigator on a particular study." + }, + { + "input": "Concept: Tumor Suppressing Subtransferable Candidate 4 (TSSC4 gene)", + "output": "Gene or Genome described as human TSSC4 wild-type allele is located in the vicinity of 11p15.5 and is approximately 3 kb in length. This allele, which encodes protein TSSC4, is putatively involved in the inhibition of cell growth. The TSSC4 gene is located in a chromosomal region that is important with respect to tumor suppression. Alterations in this region are associated with many types of cancer such as breast, lung and ovarian cancers." + }, + { + "input": "Concept: down-regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway (negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)", + "output": "something described as any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway." + }, + { + "input": "Concept: Pharyngitis - acute (Korean Standard Classification of Disease Version 5)", + "output": "Acute upper respiratory infection described as an acute and painful inflammatory process that affects the pharynx. It is usually caused by viruses and less often bacteria. Signs and symptoms include discomfort on swallowing, low-grade fever, headache, and earache." + }, + { + "input": "Concept: multiradiene synthase activity (Molecular Function)", + "output": "carbon-oxygen lyase activity, acting on phosphates described as catalysis of the reaction: 5alpha,9alpha,10beta-labda-8(20),13-dien-15-yl diphosphate <=> miltiradiene + diphosphoric acid." + }, + { + "input": "Concept: ipecac alkaloid catabolism (heterocycle catabolic process)", + "output": "something described as the chemical reactions and pathways resulting in the breakdown of isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin." + }, + { + "input": "Concept: Respiratory System, Trachea, Bronchus (Trachea)", + "output": "Other Anatomic Concept described as trachea -The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi. Bronchi-The larger air passages of the lungs arising from the terminal bifurcation of the trachea." + }, + { + "input": "Concept: monobactams (beta-Lactams)", + "output": "Antibiotics described as a compound with a four member amide ring (beta-lactam), where one member is the amide nitrogen and another is the carbonyl carbon, with bactericidal activity. Beta-lactam antibiotics act by disrupting the synthesis of the peptidoglycan layer of the bacterial cell wall." + }, + { + "input": "Concept: anus cancer, recurrent (Neoplastic Process)", + "output": "Malignant neoplasm of anal canal described as the reemergence of anal carcinoma after a period of remission." + }, + { + "input": "Concept: Bacterial oesophagitis (Disease or Syndrome)", + "output": "Disease or Syndrome described as an acute bacterial infection that affects the esophagus. Symptoms include severe pain on swallowing and retrosternal pain. Endoscopic examination reveals esophageal mucosal ulcerations and pseudomembranous formations." + }, + { + "input": "Concept: Increased length of shinbone (Anatomical Abnormality)", + "output": "something described as an abnormal increase in the length of the tibia." + }, + { + "input": "Concept: PQL17-Take Long Time to Eat (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Young Child Questionnaire Question)", + "output": "something described as pediatric Quality of Life Neuromuscular Module Acute Version 3.0 Parent Report for Young Child (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Young Child) In the past 7 days, how much of a problem has this been for your child: My child takes a long time to eat." + }, + { + "input": "Concept: Tricuspid valve (Entire heart valve)", + "output": "Body Part, Organ, or Organ Component described as a cardiac valve located between the right atrium and ventricle." + }, + { + "input": "Concept: OBNMFBT (Qualitative Concept)", + "output": "Qualitative Concept described as a description of the type of non-medical foreign body that is found in a subject." + }, + { + "input": "Concept: CASP9 Gene Product (Amino Acid, Peptide, or Protein)", + "output": "caspase described as a protein encoded by the CASP9 gene." + }, + { + "input": "Concept: cystitis; cystica (Mass of urinary bladder)", + "output": "Disease or Syndrome described as a reactive inflammatory disorder affecting the bladder. It is characterized by the development of small cysts in the bladder wall. The cysts are lined by urothelial cells." + }, + { + "input": "Concept: nickel incorporation into nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide (Molecular Function)", + "output": "peptidyl-cysteine modification described as the incorporation of nickel into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase." + }, + { + "input": "Concept: Malformations of Cerebral Cortex Development (Rare Non-Neoplastic Disorder)", + "output": "Central Nervous System described as abnormalities in the development of the CEREBRAL CORTEX. These include malformations arising from abnormal neuronal and glial CELL PROLIFERATION or APOPTOSIS (Group I); abnormal neuronal migration (Group II); and abnormal establishment of cortical organization (Group III). Many INBORN METABOLIC BRAIN DISORDERS affecting CNS formation are often associated with cortical malformations. They are common causes of EPILEPSY and developmental delay." + }, + { + "input": "Concept: TIMG0101 (TIMI Thrombus Grade Clinical Classification Question)", + "output": "Intellectual Product described as coronary Thrombus TIMI Grade (TIMI Thrombus Grade) A grade corresponding to thrombus development as defined in the grading system by the Thrombolysis in the Myocardial Infarction Group." + }, + { + "input": "Concept: Rhythm, Beta (Brain Waves)", + "output": "Organ or Tissue Function described as brain waves with frequency between 15-30 Hz seen on EEG during wakefulness and mental activity." + }, + { + "input": "Concept: Methiocarb (Pesticides)", + "output": "Pesticides described as the carbamate agent methiocarb." + }, + { + "input": "Concept: SURGICAL INSTRUMENTS, G-U, MANUAL (Medical Device)", + "output": "something described as a manual gastroenterology-urology surgical instrument and accessories is a device designed to be used for gastroenterological and urological surgical procedures. The device may be nonpowered, hand-held, or hand-manipulated. Manual gastroenterology-urology surgical instruments include the biopsy forceps cover, biopsy tray without biopsy instruments, line clamp, nonpowered rectal probe, nonelectrical clamp, colostomy spur-crushers, locking device for intestinal clamp, needle holder, gastro-urology hook, gastro-urology probe and director, nonself-retaining retractor, laparotomy rings, nonelectrical snare, rectal specula, bladder neck spreader, self-retaining retractor, and scoop." + }, + { + "input": "Concept: Ulvas (Ulvaceae)", + "output": "Ulvaceae described as a genus of GREEN ALGAE in the family Ulvaceae. Commonly know as sea lettuces, they grow attached to rocks and KELP in marine and estuarine waters." + }, + { + "input": "Concept: protein-membrane targeting (establishment of protein localization to membrane)", + "output": "Molecular Function described as the process of directing proteins towards a membrane, usually using signals contained within the protein." + }, + { + "input": "Concept: Associations and organizational systems (Associations and organizational services, systems and policies)", + "output": "Associations and organizational services, systems and policies described as administrative control and monitoring mechanisms that govern the relationships and activities of people coming together with common noncommercial interests and the establishment and conduct of associations and organizations such as mutual aid organizations, recreational and leisure organizations, cultural and religious associations and not-for-profit organizations." + }, + { + "input": "Concept: Mylohyoid muscle (Body Part, Organ, or Organ Component)", + "output": "Body Part, Organ, or Organ Component described as one of the suprahyoid muscles located superior to the anterior belly of the digastric muscle that has its origin on the mandible, its insertion on the hyoid bone, and functions to elevate the hyoid, the tongue, and the floor of the mouth." + }, + { + "input": "Concept: affirmative action (racial or ethnic related social reform)", + "output": "Laws described as programs or policies designed to actively recruit females and minority group members for employment or higher education, in an effort to correct underrepresentative distributions of these groups relative to the general population." + }, + { + "input": "Concept: infant formulas (GENERAL NUTRIENTS)", + "output": "Dietary Supplements described as a nutritional substitute for breast milk, usually with a foundation of cow or soy milk." + }, + { + "input": "Concept: Brain-Derived Neurotrophic Factor (Laboratory Procedure)", + "output": "Protein or Enzyme Type Measurement described as a measurement of the brain-derived neurotrophic factor in a biological specimen." + }, + { + "input": "Concept: Vismodegib product (Benzamide structure-containing product)", + "output": "Organic Chemical described as a substance being studied in the treatment of cancer. It blocks a type of protein involved in tissue growth and repair and may block the growth of cancer cells. It is a type of Hedgehog signaling pathway antagonist." + }, + { + "input": "Concept: (ml/min)/(mg/m2/d) (Quantitative Concept)", + "output": "Quantitative Concept described as milliliters per minute (flow rate), divided by milligrams per meter squared per day (daily dose normalized by surface area)." + }, + { + "input": "Concept: diphosphotransferase activity (transferase activity, transferring phosphorus-containing groups)", + "output": "something described as catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor)." + }, + { + "input": "Concept: cellular response to vitamin K3 (cellular response to drug)", + "output": "something described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position." + }, + { + "input": "Concept: Orthoses, Upper Limb, Total, Support (Medical Device)", + "output": "Medical Device described as total upper-limb orthoses designed to provide support and some degree of movement restriction to an upper limb. These orthoses consist of a variety of devices that assist the support and positioning of the upper limb, and may be worn by the person and/or attached to furniture, a structure, or wheelchair. Total upper-limb support orthoses are frequently used to assist the limb by positioning it in an appropriate position; dedicated upper-limb supports (e.g., slings, humeral cuffs, lapboards) are available." + }, + { + "input": "Concept: EGFR Inhibitor AZD3759 (Pharmacologic Substance)", + "output": "Organic Chemical described as an orally available inhibitor of the epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, AZD3759 binds to and inhibits the activity of EGFR as well as certain mutant forms of EGFR. This prevents EGFR-mediated signaling, and may lead to both induction of cell death and inhibition of tumor growth in EGFR-overexpressing cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization." + }, + { + "input": "Concept: naltrexone MB (Narcotic Antagonists)", + "output": "something described as the bromide salt form of methylnaltrexone, a methyl derivative of noroxymorphone with selective, peripherally-acting mu-opioid receptor antagonistic activity. Methylnaltrexone displaces opioids from peripheral opioid receptors in the gastrointestinal tract, the bladder, and the skin, thereby reversing the opioid-related peripheral side-effects, such as constipation, urinary retention, and pruritis, respectively. Unlike naltrexone and due to the presence of a positively charged nitrogen atom in methylnaltrexone, this agent does not cross the blood-brain barrier and does not affect the centrally-mediated analgesic effect of opioids. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C80569\" active clinical trials using this agent." + }, + { + "input": "Concept: berzosertib (ATR Inhibitor)", + "output": "Antineoplastic Enzyme Inhibitor described as an inhibitor of ataxia telangiectasia and rad3-related (ATR) kinase, a DNA damage response kinase, with potential antineoplastic activity. Upon administration, berzosertib selectively binds to and inhibits ATR kinase activity and prevents ATR-mediated signaling in the ATR-checkpoint kinase 1 (Chk1) signaling pathway. This prevents DNA damage checkpoint activation, disrupts DNA damage repair, and induces tumor cell apoptosis. ATR, a serine/threonine protein kinase upregulated in a variety of cancer cell types, plays a key role in DNA repair, cell cycle progression, and survival; it is activated by DNA damage caused during DNA replication-associated stress." + }, + { + "input": "Concept: Wayfinding Hospital Information Systems (Hospital Information Systems)", + "output": "something described as data management information systems designed to record, process, and display comprehensive information related to the hospital directory (e.g., doctors' suites) and also to provide directions, telephone connections, and assistance finding services. Directory and wayfinding hospital information system hardware usually includes touchscreens, high-definition displays, one or more workstations and/or information kiosks, acrylic (i.e., Plexiglas) backers, printed maps and guides. The systems also include firmware and/or software. Directory/wayfinding information systems may be operated as stand-alone systems or can be assembled in an integrated hospital-wide information system network; the systems may also provide an Internet connection. Some systems are capable of providing information in several languages." + }, + { + "input": "Concept: EIF2C4 (AGO4 gene)", + "output": "something described as human AGO4 wild-type allele is located is located in the vicinity of 1p34.3 and is approximately 50 kb in length. This allele, which encodes protein argonaute-4, is involved in RNA recognition and metabolism." + }, + { + "input": "Concept: intracellular canaliculus (Membranous cytoplasmic organelle)", + "output": "Subcellular structure described as an apical plasma membrane part that forms a narrow enfolded luminal membrane channel, lined with numerous microvilli, that appears to extend into the cytoplasm of the cell. A specialized network of intracellular canaliculi is a characteristic feature of parietal cells of the gastric mucosa in vertebrates." + }, + { + "input": "Concept: Patient Table Relationship (Orientation)", + "output": "Orientation described as the orientation of a patient in relation to the head of the table." + }, + { + "input": "Concept: BRAF c.1397G>C (BRAF gene mutation)", + "output": "something described as a nucleotide substitution at position 1397 of the coding sequence of the BRAF gene where guanine has been mutated to cytosine." + }, + { + "input": "Concept: LOCATOR, INTRACORPOREAL DEVICE, ULTRASONIC (Medical Device)", + "output": "Medical Device described as an obstetric-gynecologic ultrasonic imager is a device designed to transmit and receive ultrasonic energy into and from a female patient by pulsed echoscopy. This device is used to provide a visual representation of some physiological or artificial structure, or of a fetus, for diagnostic purposes during a limited period of time. This generic type of device may include the following: signal analysis and display equipment, electronic interfaces for other equipment, patient and equipment supports, coupling gel, and component parts. This generic type of device does not include devices used to monitor the changes in some physiological condition over long periods of time." + }, + { + "input": "Concept: ADL0208 (ADCS-ADL Severe Dementia Questionnaire Question)", + "output": "Intellectual Product described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, Severe Dementia Version - In the past 4 weeks, did {S} watch television?" + }, + { + "input": "Concept: Adenosine Diphosphate Glucose (Adenosine Diphosphate Sugars)", + "output": "Nucleic Acid, Nucleoside, or Nucleotide described as serves as the glycosyl donor for formation of bacterial glycogen, amylose in green algae, and amylopectin in higher plants." + }, + { + "input": "Concept: Oxytremorine (Pharmacologic Substance)", + "output": "Pyrrolidinones described as a non-hydrolyzed muscarinic agonist used as a research tool." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, COL1A1 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)", + "output": "Medical Device described as molecular assay reagents intended to identify mutations in the collagen, type I, alpha 1 (COL1A1) gene, located at chromosome 17q21.3-q22.1, which provides instructions to make type I collagen, pro-alpha 1 (I) chain. Mutations at this locus have been identified in patients with diseases that include osteogenesis imperfecta (types I to IV) and Ehlers-Danos syndrome." + }, + { + "input": "Concept: Pars orbitalis (Body Part, Organ, or Organ Component)", + "output": "Frontal operculum described as one of three parts of the inferior frontal gyrus that overlie the insula and form the lower boundary of the gyrus with the lateral fissure. Its boundary with the insula is the superior limiting sulcus ( Ture-1999 ). Defined by dissection, it is the most rostral of the three. The others are the triangular part of the inferior frontal gyrus and the opercular part of the inferior frontal gyrus. A component of the frontal operculum in the human ( Carpenter-1983 ), it is not present in macaques or rodents." + }, + { + "input": "Concept: C165936 (Laboratory Procedure)", + "output": "Laboratory Procedure described as a classification of the amount of Glycine max antigen IgE antibody present in a sample using the radioallergosorbent test (RAST) scoring system." + }, + { + "input": "Concept: C-SSRS Children's Baseline/Screening - Active Suicidal Ideation with Any Methods (Not Plan) without Intent to Act (C-SSRS Children's Baseline/Screening Questionnaire Question)", + "output": "Intellectual Product described as columbia-Suicidality Severity Rating Scale Children's Baseline/Screening (C-SSRS Children's Baseline/Screening) Have you thought about how you would do that or how you would make yourself not alive anymore (kill yourself)? What did you think about? (Lifetime)." + }, + { + "input": "Concept: MSCV (MGMTP140K) Retroviral Vector-Transduced CD34+ Autologous PBSC (Pharmacologic Substance)", + "output": "therapeutic autologous lymphocytes described as CD34+ peripheral blood stem cells (PBSC) isolated from patient with hematopoietic cell tumor, and transfected with murine stem cell virus retroviral vector encoding a mutant version of the human DNA repair protein O6-alkylguanine-DNA methyltransferase (MGMT). This mutant MGMT protein, MGMTP140K, is resistant to the O6-benzylguanine (BG), an inhibitor of the wild type MGMT. Introduction of these transfected autologous PBSCs back to the patient, may stimulate the expression of the O6 BG resistant mutant MGMT protein, which when used in combination with O6-alkylating drugs could protect the hematopoietic system against the hematopoietic toxicity of chemotherapeutic agents." + }, + { + "input": "Concept: 2'-C-methylcytidine 3'-O-L-valinyl ester (pyrimidine analog)", + "output": "something described as the 3-O-valine ester prodrug of the nucleoside analog 2'-C-methylcytidine with anti-hepatitis C virus (HCV) activity. Upon administration, valopicitabine is converted into 2'-C-methylcytidine; upon phosphorylation into its 5-triphosphate form, this metabolite inhibits viral RNA chain elongation and viral RNA-dependent RNA polymerase activity. This blocks viral production of HCV RNA and thus viral replication." + }, + { + "input": "Concept: FLJ22057 (ZNRF3 gene)", + "output": "ZNRF3 gene described as human ZNRF3 wild-type allele is located in the vicinity of 22q12.1 and is approximately 174 kb in length. This allele, which encodes E3 ubiquitin-protein ligase ZNRF3 protein, plays a role in the both Wnt pathway modulation and protein modification." + }, + { + "input": "Concept: Multiple Abnormalities (Intellectual Product)", + "output": "Intellectual Product described as the presence of more than one anomaly." + }, + { + "input": "Concept: SF-36 v1.0 Acute - Question 9c (Intellectual Product)", + "output": "SF36 v1 0 Acute Questionnaire Question described as the Short Form 36 Health Survey Acute, Version 1.0 (SF36 v1.0 Acute) Question 9c." + }, + { + "input": "Concept: Birch Pollen IgG AB RAST Score (Laboratory Procedure)", + "output": "something described as a classification of the amount of Betula pollen IgG antibody, using the RAST (radioallergosorbent test) scoring system, in a biological specimen." + }, + { + "input": "Concept: glial cell activation (Cell Function)", + "output": "cell activation described as a change in morphology and behavior of a glial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." + }, + { + "input": "Concept: Synovial capsule of joint (Synovial sac)", + "output": "Body Part, Organ, or Organ Component described as synovial sac, the synovial membrane of which together with articular cartilage encloses a synovial cavity" + }, + { + "input": "Concept: porous cell septum (Cell Component)", + "output": "something described as a septum or cross wall which does not entirely span the space between two portions of cell wall and may contain a specialized central pore structure. A porous septum allows the movement of organelles and/or cytoplasm between compartments." + }, + { + "input": "Concept: acyl-CoA:sphingosine N-acyltransferase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine." + }, + { + "input": "Concept: MPAI115 (MPAI-4 Questionnaire Question)", + "output": "MPAI-4 Questionnaire Question described as mayo-Portland Adaptability Inventory-4 - Verbal or physical expressions of anger." + }, + { + "input": "Concept: Celecoxib product (C [Preparations])", + "output": "Chemical categorised functionally described as a nonsteroidal anti-inflammatory drug (NSAID) with a diaryl-substituted pyrazole structure. Celecoxib selectively inhibits cyclo-oxygenase-2 activity (COX-2); COX-2 inhibition may result in apoptosis and a reduction in tumor angiogenesis and metastasis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1728\" active clinical trials using this agent." + }, + { + "input": "Concept: CD2LY (Laboratory Procedure)", + "output": "Laboratory Procedure described as the determination of the ratio of CD2 expressing cells compared with the total number of lymphocytes in a sample. The measurement may be expressed as a ratio or percentage." + }, + { + "input": "Concept: Nongranulomatous uveitis (Disease or Syndrome)", + "output": "something described as a form of uveitis that is not associated with the formation of granulomas." + }, + { + "input": "Concept: Tourniquets, Pneumatic, Automated (Tourniquets, Pneumatic)", + "output": "something described as pneumatic tourniquets designed to circumferentially constrict/compress circumferentially an extremity for a limited period of time by applying a precise amount of pressure using an automated gas-inflated cuff. The pressure is applied upon the limb surface and underlying tissues using the cuff; pressure is then transferred to the blood vessels causing a temporary occlusion. The pressure should be at least equal or higher than the minimum required to occlude the blood flow (i.e., limb occlusion pressure or [LOP]). These tourniquets typically include an inflatable cuff and a compressed gas source. Automated tourniquets include a control unit that supplies the compressed gas from a gas cartridge, central supply system, a small gas container (e.g., a cylinder), or from an integral electric pump. Automated tourniquets also include controls, regulators, monitors for the applied pressure, and alarms for abnormal conditions; computerized automated tourniquets can perform self-calibration checks and display elapsed inflation time. Automated pneumatic tourniquets are used mainly during surgical procedures on the extremities enabling surgeons to perform delicate procedures in bloodless operative fields." + }, + { + "input": "Concept: Evaluates correct processes have been performed for specimen handling and disposition (Health Care Activity)", + "output": "Health Care Activity described as verifies specimen-handling process was followed to ensure correct collection, identification, labeling, storage preservation, and transportation per facility policy." + }, + { + "input": "Concept: Autosomal recessive cerebral atrophy (Cerebral atrophy)", + "output": "something described as a rare genetic neurodegenerative disorder with characteristics of ventriculomegaly and progressive symmetrical atrophy of the cerebral cortex grey and white matter (sparing the midbrain, brainstem, cerebellum and infratentorial segments). The disease manifests in early infancy with acquired microcephaly, irritability, regression of developmental milestones, feeding difficulties, akathisia, exaggerated startle response, spasticity (fisted hands, stiff arms, leg scissoring), abnormal muscle tone with hypotonic trunk and hypertonic extremities, visual impairment and seizures." + }, + { + "input": "Concept: prefrontal cortex (Body Part, Organ, or Organ Component)", + "output": "frontal lobe described as was used by Brodmann for the frontal lobe excluding its cytoarchitecturally defined precentral region. On the medial surface of the hemisphere its boundary with the cingulate region is an arc formed by the cingulate sulcus above and by the superior rostral sulcus below. It includes the area 8 of Brodmann (human), the area 9 of Brodmann (human), the area 10 of Brodmann (human), the area 11 of Brodmann (human), the area 44 of Brodmann, the area 45 of Brodmann (human), the area 47 of Brodmann (human) and the area 46 of Brodmann (human). Most authors now consider Brodmann's frontal region to be an approximate equivalent to the combination of the lateral prefrontal cortex and the lateral part of the orbitomedial prefrontal cortex ( Brodmann-1909, Anthoney-1994 )." + }, + { + "input": "Concept: L-arabinose 1-dehydrogenase (NADP+) activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)", + "output": "Molecular Function described as catalysis of the reaction: L-arabinose + NADP+ = L-arabinono-1,4-lactone + NADPH + H+." + }, + { + "input": "Concept: saccharate biosynthesis (glucarate biosynthetic process)", + "output": "something described as the chemical reactions and pathways resulting in the formation of D-glucarate, the D-enantiomer of glucarate." + }, + { + "input": "Concept: Bone structure of spine (Body Part, Organ, or Organ Component)", + "output": "Bone Tissue described as one of the bones that make up the vertebral column." + }, + { + "input": "Concept: trachea morphogenesis (animal organ morphogenesis)", + "output": "animal organ morphogenesis described as the process in which a trachea is generated and organized. The trachea is the portion of the airway that attaches to the bronchi as it branches." + }, + { + "input": "Concept: CD332 Antigen V679F (FGFR2 Protein Variant)", + "output": "FGFR2 Protein Variant described as a change in the amino acid residue at position 679 in the fibroblast growth factor receptor 2 protein where valine has been replaced by phenylalanine." + }, + { + "input": "Concept: Catheters, Spinal, Intervertebral Disc, Radiofrequency Ablation (Spinal catheter)", + "output": "Spinal catheter described as spinal catheters designed for introduction into an intervertebral disk to perform ablation by delivering radiofrequency (RF) current through the tissues. These catheters include a needle electrode at the distal tip to deliver the RF current to a neutral electrode located externally on the patient's skin (i.e., monopolar systems). The catheter is usually introduced through a hollow needle previously inserted percutaneously in the disc and is then maneuvered around the outer edge of the central nucleus of the disc. Power is supplied to the catheter from an RF generator that includes connectors and/or adapters specially designed for use with the catheter. RF ablation intervertebral disc catheters are used in outpatient procedures to treat chronic, long-term discogenic pain." + }, + { + "input": "Concept: cusp (TEETH, GUMS AND SUPPORTING STRUCTURES: GENERAL TERMS)", + "output": "TEETH, GUMS AND SUPPORTING STRUCTURES: GENERAL TERMS described as a raised area of the biting surface of a tooth." + }, + { + "input": "Concept: LCIS, NOS (Breast and nipple neoplasms malignant)", + "output": "Mammary Neoplasms described as a non-invasive adenocarcinoma characterized by a proliferation of monomorphic cells completely filling the lumina. The overall lobular architecture is preserved. It is frequently multifocal (90% in some series) and bilateral. It seldom becomes invasive; however there is an increased risk of infiltrating ductal adenocarcinoma. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C4018\" active clinical trials using this agent." + }, + { + "input": "Concept: Delphinium nuttallianum, Flower essence (Flower Essences)", + "output": "Pharmacologic Substance described as larkspur." + }, + { + "input": "Concept: Ratio of pulmonic valve acceleration time to ejection time (Clinical Attribute)", + "output": "Pulmonary valve feature described as ratio of Pulmonic Valve Acceleration Time to Pulmonic Valve Ejection Time" + }, + { + "input": "Concept: Mould Element (Depsipeptide Antineoplastic Antibiotic)", + "output": "something described as a cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and related to the enniatins. It is composed of 3 moles each of L-valine, D-alpha-hydroxyisovaleric acid, D-valine, and L-lactic acid linked alternately to form a 36-membered ring. (From Merck Index, 11th ed) Valinomycin is a potassium selective ionophore and is commonly used as a tool in biochemical studies." + }, + { + "input": "Concept: Chemoinformatics (Intellectual Product)", + "output": "Informatics described as the use of computational and data retrieval techniques in understanding problems of chemistry. Cheminformatics strategies are useful in high throughput drug discovery." + }, + { + "input": "Concept: QS-SGRQ Past 4 Weeks Version TEST (CDISC Questionnaire Terminology)", + "output": "CDISC Questionnaire Terminology described as test names of questionnaire questions associated with the St. George's Respiratory Questionnaire Past 4 Weeks Version (SGRQ Past 4 Weeks Version) for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: Hepatosplenomegaly (Abnormal liver morphology)", + "output": "Hepatobiliary Disorder described as an abnormal enlargement of both the liver and spleen." + }, + { + "input": "Concept: Elected (Action)", + "output": "Activity described as select from a group." + }, + { + "input": "Concept: protein tyrosine phosphatase receptor type S (Gene or Genome)", + "output": "Receptor-Type Protein Tyrosine Phosphatase Gene described as this gene is involved in protein dephosphorylation." + }, + { + "input": "Concept: Peak expiratory flow rate increased (Respiratory System Finding)", + "output": "Measurement finding above reference range described as an increase of the greatest rate of flow that can be achieved during forced expiration beginning with the lungs fully inflated." + }, + { + "input": "Concept: Abnormal metabolism (Abnormality of metabolism/homeostasis)", + "output": "something described as an abnormality in the function of the chemical reactions related to processes including conversion of food to enter, synthesis of proteins, lipids, nucleic acids, and carbohydrates, or the elimination of waste products. []" + }, + { + "input": "Concept: BRAF Class 3 Gene Mutation (Cell or Molecular Dysfunction)", + "output": "Cell or Molecular Dysfunction described as a change in the nucleotide sequence of the BRAF gene that inhibits expression or results in the translation of either low-activity or inactive forms of the serine/threonine-protein kinase B-raf protein." + }, + { + "input": "Concept: Stage IIIB Prostate Cancer AJCC v8 (Stage III Prostate Cancer AJCC v8)", + "output": "Stage III Prostate Carcinoma described as stage IIIB includes: T3-4, N0, M0, PSA: Any, Grade Group 1-4; T3: Prostate cancer with extraprostatic tumor that is not fixed or does not invade adjacent structures. T4: Prostate cancer in which the tumor is fixed or invades adjacent structures other than seminal vesicles such as external sphincter, rectum, bladder, levator muscles, and/or pelvic wall. N0: Prostate cancer with no positive regional nodes. M0: Prostate cancer without evidence of distant metastasis. Grade Group 1: Gleason Score 6 or less, Gleason Pattern 3 or less+3. Grade Group 2: Gleason Score 7, Gleason Pattern 3+4. Grade Group 3: Gleason Score 7, Gleason Pattern 4+3. Grade Group 4: Gleason Score 8, Gleason Pattern 4+4." + }, + { + "input": "Concept: Duplication of the middle bone of the little toe (Abnormality of the middle phalanx of the 5th toe)", + "output": "Abnormality of the middle phalanx of the 5th toe described as partial or complete duplication of the middle phalanx of the 5th toe." + }, + { + "input": "Concept: Villous degeneration (gastrointestinal)", + "output": "something described as the enteric villi are atrophic or absent." + }, + { + "input": "Concept: spleen; agenesis (Congenital anomaly of spleen)", + "output": "Congenital anomaly of spleen described as absence (aplasia) of the spleen." + }, + { + "input": "Concept: U4/U6 snRNP location (spliceosomal snRNP complex)", + "output": "Cell Component described as a ribonucleoprotein complex that contains base-paired U4 and U6 small nuclear RNAs." + }, + { + "input": "Concept: Lactobacillus product (Product containing microbial agent)", + "output": "Anaerobic non-sporing Gram-positive bacillus described as any bacteria that is not assigned to the species level but can be assigned to the Lactobacillus genus level." + }, + { + "input": "Concept: interleukin-35 production (Organism Function)", + "output": "something described as the appearance of interleukin-35 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." + }, + { + "input": "Concept: icosanoid transport (carboxylic acid transport)", + "output": "Cell Function described as the directed movement of icosanoids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Icosanoids are unsaturated C20 fatty acids and skeletally related compounds." + }, + { + "input": "Concept: Anti-EGFR Monoclonal Antibody GT-MAB 5.2-GEX (Antineoplastic Antibody)", + "output": "Anti-EGFR Monoclonal Antibody described as a glycoengineered form of a human monoclonal antibody directed against the epidermal growth factor receptor (EGFR) with potential antineoplastic activity. Anti-EGFR monoclonal antibody GT-MAB 5.2-GEX specifically binds to the extracellular domain of EGFR, thereby potentially inducing an antibody-dependent cell-mediated cytotoxicity (ADCC) against EGFR-expressing tumor cells, eventually leading to tumor cell apoptosis and an inhibition of tumor cell growth. EGFR, a member of the epidermal growth factor family of extracellular protein ligands, is overexpressed on the cell surfaces of various solid tumors. This antibody has a specific glycosylation profile that may enhance its ADCC response against EGFR-expressing tumor cells." + }, + { + "input": "Concept: immune tolerance/unresponsiveness (Disease or Syndrome)", + "output": "Immune status described as failure to respond to contact with antigen; may be specific for a given antigen (tolerance) or generalized to many antigens, as in immunodeficiency states." + }, + { + "input": "Concept: PCLP-1 (Gene or Genome)", + "output": "PODXL gene described as human PODXL wild-type allele is located within 7q32-q33 and is approximately 58 kb in length. This allele, which encodes podocalyxin protein, is involved in both cell-cell adhesion and cell migration. Aberrant expression of the gene in tumors is associated with a poor prognosis." + }, + { + "input": "Concept: mental retardation-congenital contractures-low fingertip arches syndrome (Disease or Syndrome)", + "output": "something described as mental retardation syndrome with microcephaly, facial abnormalities, exotropia, hypogonadism, joint hypermobility, rockerbottom feet, fingertip arches, and other defects." + }, + { + "input": "Concept: Human adenovirus 40/41 DNA (Laboratory Procedure)", + "output": "Laboratory Procedure described as a measurement of the Human adenovirus type 40 and/or Human adenovirus type 41 DNA in a biological specimen." + }, + { + "input": "Concept: Appendix Neuroendocrine Tumor cM1 TNM Finding v8 (Appendix Neuroendocrine Tumor Clinical Distant Metastasis TNM Finding v8)", + "output": "something described as appendix neuroendocrine tumor with distant metastasis." + }, + { + "input": "Concept: Multiple Transversion Mutations (Cell or Molecular Dysfunction)", + "output": "Cell or Molecular Dysfunction described as multiple point mutations in a DNA sequence from eukaryotic or prokaryotic organisms in which each mutation occurs by substitution of a purine base for a pyrimidine base or vice versa. These abnormalities can be either heritable or occur somatically." + }, + { + "input": "Concept: FAC04102 (Intellectual Product)", + "output": "something described as functional Assessment of Cancer Therapy-Kidney Symptom Index-Disease-Related Symptoms Version 4 (FKSI-DRS Version 4) I have pain." + }, + { + "input": "Concept: Stage IV Squamous Cell Carcinoma of the Lung (Neoplastic Process)", + "output": "Neoplastic Process described as stage IV includes: (Any T, Any N, M1a); (Any T, Any N, M1b). M1a: Lung cancer with separate tumor nodule(s) in a contralateral lobe; tumor with pleural nodules or malignant pleural (or pericardial) effusion. M1b: Distant metastasis." + }, + { + "input": "Concept: Skin Response Reference Identifier (Reference ID)", + "output": "something described as a character or string used to name, or characterize a Skin Response reference." + }, + { + "input": "Concept: regulation of sporulation resulting in formation of a cellular spore (Cell Function)", + "output": "regulation of sporulation described as any process that modulates the frequency, rate or extent of spore formation." + }, + { + "input": "Concept: SURG DIAG TECHNICS (Diagnostic Procedure)", + "output": "general diagnostic method described as methods and procedures for the diagnosis of disease or dysfunction by examination of the pathological site or operative field during surgical intervention." + }, + { + "input": "Concept: EXACT1 (Clinical or Research Assessment Questionnaire)", + "output": "Intellectual Product described as a standardized rating scale developed by Nancy Leidy and Lindsey Murray under the EXACT-PRO Initiative in 2013, which is used to make symptomatic assessment of chronic obstructive pulmonary disease (COPD) exacerbations. The questionnaire contains 14 items and evaluate the frequency, severity, and duration of COPD exacerbations." + }, + { + "input": "Concept: Education, Continuing (Curricula)", + "output": "Educational Activity described as formal or informal courses, educational programs or services, usually at the postsecondary level, designed to advance or update adult learning for personal, academic, or occupational and professional purposes." + }, + { + "input": "Concept: mitochondrial magnesium ion transmembrane transport (magnesium ion transmembrane transport)", + "output": "magnesium ion transmembrane transport described as the process in which a magnesium ion (Mg2+) is transported across a mitochondrial membrane, into or out of the mitochondrion." + }, + { + "input": "Concept: Unbalanced atrioventricular canal defect (Heart)", + "output": "something described as anatomic features of unbalanced atrioventricular septal defect (AVSD) include varying amounts of ventricular hypoplasia, as well as malalignment of the atrioventricular junction. In complete AVSD, the common AV valve can be situated either equally over the right and left ventricles (balanced) or unequally over the ventricles (unbalanced)." + }, + { + "input": "Concept: Systolic click (Finding)", + "output": "Finding described as an auscultated finding describing a sharp, high-frequency sound heard during auscultation of the thorax caused by valvular prolapse or stenosis." + }, + { + "input": "Concept: Space of second intercostal compartment (Body Space or Junction)", + "output": "Body Space or Junction described as intercostal compartment space between secondt and third ribs." + }, + { + "input": "Concept: Complement, C2a (Complement 2)", + "output": "Amino Acid, Peptide, or Protein described as the COOH-terminal fragment of COMPLEMENT 2, released by the action of activated COMPLEMENT C1S. It is a SERINE PROTEASE. C2a combines with COMPLEMENT C4B to form C4b2a (CLASSICAL PATHWAY C3 CONVERTASE) and subsequent C4b2a3b (CLASSICAL PATHWAY C5 CONVERTASE)." + }, + { + "input": "Concept: Were you satisfied with the medical care you received (Clinical or Research Assessment Question)", + "output": "Intellectual Product described as a question about whether an individual is or was satisfied with the medical care they received." + }, + { + "input": "Concept: Grade III Lymphomatoid Granulomatosis (Adult Diffuse Large B-Cell Lymphoma)", + "output": "Aggressive Adult Non-Hodgkin Lymphoma described as grade III lymphomatoid granulomatosis that occurs in adulthood." + }, + { + "input": "Concept: PQL18-Hard for Family to Plan Activities (Intellectual Product)", + "output": "PedsQL Neuromuscular Module Acute Version 3.0 Parent of Toddler Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Acute Version 3 Toddler Parent Report - In the past 7 days, how much of a problem has this been for your child: It is hard for our family to plan activities like vacations." + }, + { + "input": "Concept: negative regulation of SREBP-mediated signaling pathway in response to increased oxygen levels (Molecular Function)", + "output": "something described as any process that stops, prevents or reduces the frequency, rate or extent of the SREBP signaling pathway in response to an increase in oxygen levels." + }, + { + "input": "Concept: Unable to Wash or Dress (Intellectual Product)", + "output": "Intellectual Product described as a response indicating that an individual is unable to wash or dress their self." + }, + { + "input": "Concept: Brunemycin (Antibiotic)", + "output": "something described as an aminoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces flocculus. Streptonigrin complexes with DNA and topoisomerase II, resulting in DNA cleavage and inhibition of DNA replication and RNA synthesis. This agent also acts as a reverse transcriptase inhibitor and causes free radical-mediated cellular damage. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C844\" active clinical trials using this agent." + }, + { + "input": "Concept: ENDOCRINE SYSTEM (Clinical history and observation findings)", + "output": "Finding by Site or System described as normal or abnormal clinical findings related to the collection of tissues capable of secreting hormones." + }, + { + "input": "Concept: hereditary spherocytosis (Disease or Syndrome)", + "output": "Spherocytosis described as a group of familial congenital hemolytic anemias characterized by numerous abnormally shaped erythrocytes which are generally spheroidal. The erythrocytes have increased osmotic fragility and are abnormally permeable to sodium ions." + }, + { + "input": "Concept: Dibenzofurans (Heterocyclic Compounds, 3-Ring)", + "output": "Organic Chemical described as compounds that include the structure of dibenzofuran." + }, + { + "input": "Concept: Interpersonal Influence (Social Behavior)", + "output": "Social Behavior described as effect one individual has on another with or without apparent intention or direct exercise of command." + }, + { + "input": "Concept: Folate In Dietary Folate Equivalents (folate)", + "output": "folate described as total folate activity which adjusts for the lower bioavailability of folate in food compared to folic acid using an accepted conversion formula." + }, + { + "input": "Concept: Focal pancreatic islet hyperplasia (Islets of Langerhans hyperplasia)", + "output": "something described as hyperplasia of the islets of Langerhans that affects only certain regions of the pancreas and not others. []" + }, + { + "input": "Concept: undef.Orntl therp narr req'd (Therapeutic or Preventive Procedure)", + "output": "Oriental therapies described as any elsewhere undefined Oriental therapy, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com." + }, + { + "input": "Concept: Cerebrovascular (Qualitative Concept)", + "output": "Anatomy Qualifier described as relating to the brain and the blood vessels that supply it." + }, + { + "input": "Concept: Velocity Encoding Minimum Value (Qualitative Concept)", + "output": "Numerical value described as the minimum velocity encoded by the phase encoding gradient." + }, + { + "input": "Concept: Chain Initiation, Peptide, Translational (Genetic Function)", + "output": "Protein Biosynthesis described as a process of GENETIC TRANSLATION whereby the formation of a peptide chain is started. It includes assembly of the RIBOSOME components, the MESSENGER RNA coding for the polypeptide to be made, INITIATOR TRNA, and PEPTIDE INITIATION FACTORS; and placement of the first amino acid in the peptide chain. The details and components of this process are unique for prokaryotic protein biosynthesis and eukaryotic protein biosynthesis." + }, + { + "input": "Concept: Autobiographical Memory (Mental Process)", + "output": "memory by content described as type of declarative memory, consisting of personal memory in contrast to general knowledge." + }, + { + "input": "Concept: establishment of protein localisation to peroxisome (protein localization to peroxisome)", + "output": "establishment of protein localization to organelle described as the directed movement of a protein to a specific location in a peroxisome." + }, + { + "input": "Concept: Wisteria (Wisterieae)", + "output": "Fabaceae described as a plant genus of the family FABACEAE. Members contain wistarin, wisteria lectin and wistariasaponin." + }, + { + "input": "Concept: oxidoreductase activity, acting on haem group of donors, oxygen as acceptor (Molecular Function)", + "output": "something described as catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces oxygen." + }, + { + "input": "Concept: lymphocyte antigen 94 (mouse) homolog (Receptor Gene)", + "output": "Gene or Genome described as this gene is involved in the activation of natural killer cell-mediated cytotoxicity." + }, + { + "input": "Concept: Pituitary Adenomas (Benign adenomatous neoplasm - category)", + "output": "ENDOCRINE FEATURES described as a benign epithelial tumor derived from intrinsic cells of the adenohypophysis." + }, + { + "input": "Concept: Other Life, Physical, and Social Science Workers (Professional or Occupational Group)", + "output": "something described as life, physical, and social science workers not specifically identified elsewhere." + }, + { + "input": "Concept: Grade 2 Chills, CTCAE (Chills, CTCAE)", + "output": "Chills, CTCAE described as moderate tremor of the entire body; narcotics indicated" + }, + { + "input": "Concept: Eucommia ulmoides Oliv., 1890 (Eucommia)", + "output": "something described as a species of the family EUCOMMIACEAE." + }, + { + "input": "Concept: bile duct; adenoma, extrahepatic (Bile duct adenoma)", + "output": "Bile duct adenoma described as an adenoma that arises from the extrahepatic bile ducts. It is classified as papillary, tubular, or tubulopapillary." + }, + { + "input": "Concept: B-Cell Maturation Protein (Tumor Necrosis Factor Receptor)", + "output": "Amino Acid, Peptide, or Protein described as tumor necrosis factor receptor superfamily member 17 (184 aa, ~20 kDa) is encoded by the human TNFRSF17 gene. This protein is involved in both ligand binding and cytokine signaling." + }, + { + "input": "Concept: Gonococcal conjunctivitis (Neonatal infectious disorder)", + "output": "Neonatal infectious disorder described as inflammation of the conjunctiva in a newborn due to Neisseria gonorrhoeae which was acquired during labor and delivery." + }, + { + "input": "Concept: Zona glomerulosa of suprarenal gland (Region of adrenal cortex)", + "output": "Adrenal Cortex described as the narrow subcapsular outer zone of the adrenal cortex. This zone produces a series of enzymes that convert PREGNENOLONE to ALDOSTERONE. The final steps involve three successive oxidations by CYTOCHROME P-450 CYP11B2." + }, + { + "input": "Concept: positive regulation of response to signal involved in DNA integrity checkpoint (regulation of response to DNA integrity checkpoint signaling)", + "output": "regulation of response to DNA integrity checkpoint signaling described as any process that activates or increases the frequency, rate or extent of response to DNA integrity checkpoint signaling." + }, + { + "input": "Concept: Grade 4 Duodenal obstruction (Finding)", + "output": "Finding described as life-threatening consequences; urgent operative intervention indicated" + }, + { + "input": "Concept: HECT domain binding (Molecular Function)", + "output": "something described as interacting selectively and non-covalently with a HECT, 'Homologous to the E6-AP Carboxy-Terminus', domain of a protein." + }, + { + "input": "Concept: Natural Fiber Dressings, Non-Impregnated (Medical Device)", + "output": "something described as plain (nonimpregnated) dressings made of materials derived from natural fibers. These dressings are usually nonadhesive, made of one or more fibers, including cotton and alginate. Natural fiber dressings are intended to absorb wound exudates and maintain a moist environment; they are used mainly in wound management." + }, + { + "input": "Concept: 4H-1-Benzopyran-8-carboxylic acid, 3-methyl-4-oxo-2-phenyl-, 2-(1-piperidinyl)ethyl ester (Genitourinary smooth muscle relaxant)", + "output": "Allergen class described as a drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist." + }, + { + "input": "Concept: HISTONE GENE CLUSTER 3, H2B HISTONE FAMILY, MEMBER B (Gene or Genome)", + "output": "something described as this gene plays a role in organization of chromatin-containing structures." + }, + { + "input": "Concept: Reaction (Beginning)", + "output": "Property or Attribute described as a response generated by a stimulus." + }, + { + "input": "Concept: Running or Jogging 3 Miles in 30 Minutes or Less (Intellectual Product)", + "output": "something described as a question about an individual's ability to run or jog 3 miles in 30 minutes or less." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, TSC2 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation described as molecular assay reagents intended to identify mutations in the tuberous sclerosis 1 (TSC1) gene, located at chromosome 9q34, which is implicated as a tumor suppressor. This inherited genetic mutation has been identified in patients with tuberous sclerosis type 1; it is also associated with focal cortical dysplasia of Taylor balloon cell subtype (epilepsy-associated) and lymphangiomyomatosis in females." + }, + { + "input": "Concept: Recorders, Ocular Pressure (Recorders, Physiologic)", + "output": "Recorders, Physiologic described as a tonometer and accessories is a manual device intended to measure intraocular pressure by applying a known force on the globe of the eye and measuring the amount of indentation produced (Schiotz type) or to measure intraocular tension by applanation (applying a small flat disk to the cornea). Accessories for the device may include a tonometer calibrator or a tonograph recording system. The device is intended for use in the diagnosis of glaucoma." + }, + { + "input": "Concept: regulation of deoxyribonucleic acid duplicase activity (regulation of DNA-dependent DNA replication)", + "output": "regulation of transferase activity described as any process that modulates the frequency, rate or extent of DNA-directed DNA polymerase activity." + }, + { + "input": "Concept: SYSTEM/DEVICE, PHARMACY COMPOUNDING (Medical Device)", + "output": "Medical Device described as an intravascular administration set is a device used to administer fluids from a container to a patient's vascular system through a needle or catheter inserted into a vein. The device may include the needle or catheter, tubing, a flow regulator, a drip chamber, an infusion line filter, an I.V. set stopcock, fluid delivery tubing, connectors between parts of the set, a side tube with a cap to serve as an injection site, and a hollow spike to penetrate and connect the tubing to an I.V. bag or other infusion fluid container." + }, + { + "input": "Concept: FASCITIS (Musculoskeletal and connective tissue infections and inflammations NEC)", + "output": "Abnormality of the fascia described as inflammation of the fascia." + }, + { + "input": "Concept: Membranous choanal atresia (Pathologic Function)", + "output": "Pathologic Function described as absence of the normal opening of the choana (the posterior nasal aperture) as a result of an obstructing choanal membrane that may be thin and strandlike or thick and pluglike." + }, + { + "input": "Concept: Tobacco Cessation Counseling (Counseling)", + "output": "Smoking cessation assistance described as a process by which a health professional provides education, recommendations, or interventions to help clients stop using tobacco products." + }, + { + "input": "Concept: orbital prefrontal cortex (Body Part, Organ, or Organ Component)", + "output": "prefrontal cortex described as a segmentation of the orbital gyri on the basis of multiple stains for internal structure. One of two subdivisions of the orbitomedial prefrontal cortex, it is composed of six areas. In the human they are: area 10, area 11, area 47/12, area 13, area 14, and the agranular orbitofrontal cortex ( Ongur-2003 ). In the macaque they are the same, except that area 47/12 is named area 12 (macaque) ( Carmichael-1994 ). The other division of the orbitomedial prefrontal cortex is the medial prefrontal cortex of Ongur.\\r\\nIn both the human and the macaque the orbital prefrontal cortex is largely granular cortex, which has no equivalent in the rat. Only the most caudal strip of the orbital prefrontal cortex is agranular. The equivalent of that narrow area may be found in the orbital areas (rodent) and the agranular insular cortex of the rodent ( Preuss-1995; Wallis-2012 )." + }, + { + "input": "Concept: RNA-Binding Protein EWS/Transcription Factor Sp3 Fusion Protein (Fusion protein)", + "output": "Fusion protein described as a fusion protein encoded by the EWSR1/SP3 fusion gene. This protein is comprised of the transactivation domain of the RNA-binding protein EWS fused to a C2H2 zinc finger DNA binding domain of the transcription factor Sp3 protein." + }, + { + "input": "Concept: Melanoma of the Skin pM1a TNM Finding v8 (Cutaneous Melanoma pM1 TNM Finding v8)", + "output": "Finding described as cutaneous melanoma with distant metastasis to skin, soft tissue including muscle, and/or nonregional lymph node. LDH level not recorded or unspecified." + }, + { + "input": "Concept: Advanced Bladder Carcinoma (Advanced Genitourinary System Carcinoma)", + "output": "Advanced Genitourinary System Carcinoma described as a bladder carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment." + }, + { + "input": "Concept: Infections, Cross (Communicable Diseases)", + "output": "something described as any infection which a patient contracts in a health-care institution." + }, + { + "input": "Concept: Methylenedioxymethamphetamine Measurement (Amphetamine Drug Class Measurement)", + "output": "something described as the determination of the amount of 3,4-methylenedioxymethamphetamine (MDMA) present in a sample." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, EGR2 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)", + "output": "something described as molecular assay reagents intended to identify deletions or duplications of the early growth response 2 (EGR2) gene, located at chromosome 10q21.1, which encodes the protein E3 SUMO-protein ligase EGR2. Genetic variants at this locus have been associated with Charcot-Marie-Tooth disease, congenital hypomyelinating neuropathy, and Dejerine-Sottas disease." + }, + { + "input": "Concept: D-glutamyl transpeptidase activity (Molecular Function)", + "output": "aminoacyltransferase activity described as catalysis of the reaction: L(or D)-glutamine + D-glutamyl-peptide = NH3 + 5-glutamyl-D-glutamyl-peptide." + }, + { + "input": "Concept: quality of chest pain (ACC-AHA Measure)", + "output": "ACC-AHA Measure described as the characteristics of chest pain as described by the patient." + }, + { + "input": "Concept: basses (Fishes)", + "output": "Fish described as common name for FISHES belonging to the order Perciformes and occurring in three different families." + }, + { + "input": "Concept: (2R,3R,3aS,7R,8aS,9S,10aR,11S,12R,13aR,13bS,15S,18S,21S,24S,26R,28R,29aS)-2- [(2S)-3-amino-2-hydroxypropyl]-3-methoxy-26-methyl-20,27-dimethylidenehexacosahydro- 11,15:18,21:24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo[3,2- i]furo[2',3':5,6]pyrano[4,3-b][1,4]dioxacyclopentacosin-5(4H)-one methanesulfonate (Vinca-Domain Binding Agent)", + "output": "Ketones described as an analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity. Eribulin binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially, tumor regression." + }, + { + "input": "Concept: Charcot-Marie-Tooth disease Type 4B2 (Charcot-Marie-Tooth disease type 4)", + "output": "Disease or Syndrome described as charcot-Marie-Tooth disease, type 4B2 (CMT4B2) is a severe early-onset demyelinating CMT peripheral sensorimotor polyneuropathy. Clinically and pathologically very similar to Charcot-Marie-Tooth type 4B1 with childhood-onset of muscle weakness, sensory loss, reduced nerve conduction velocities, characteristic myelin outfoldings and a severe disease course. However, in addition to the severe neuropathy, patients from some CMT4B2 families also develop early-onset glaucoma. Caused by mutations in the MTMR13/SBF2 gene encoding a protein involved in polyphosphoinositide signaling. Transmitted in an autosomal recessive manner." + }, + { + "input": "Concept: Sympathomimetic agent, NOS (Respiratory sympathomimetic agent)", + "output": "Autonomic Agents described as drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters." + }, + { + "input": "Concept: Leptothrix buccalis (Bacterium)", + "output": "something described as a species of Gram-negative, anaerobic bacillus in the phylum Fusobacteria." + }, + { + "input": "Concept: cardiovascular pharmacology (Pharmacology)", + "output": "Pharmacology described as cardiovascular Pharmacology; the study of the effects of drugs upon the heart or circulatory system" + }, + { + "input": "Concept: Muscle (Body tissue)", + "output": "Body tissue described as tissue, which consists of muscle cells surrounded by sheets of collagen. Examples: cardiac muscle, skeletal muscle, smooth muscle." + }, + { + "input": "Concept: ENCEPHALOCRANIOCUTANEOUS LIPOMATOSIS (Congenital diffuse lipomatosis)", + "output": "Benign neoplasm of skin described as a rare neoplastic syndrome characterized by the presence of unilateral lipomas of the cranium, face and neck, and ipsilateral cerebral malformations." + }, + { + "input": "Concept: HIV-2 Seroreactivity Measurement (Seroreactivity)", + "output": "something described as the determination of the HIV-2 seroreactivity present in a sample." + }, + { + "input": "Concept: Explosion (Finding)", + "output": "Finding described as problem with the device associated with the violent bursting due to the sudden expansion of air, gas or fluid." + }, + { + "input": "Concept: MicroRNA 368 Gene (MIR376C gene)", + "output": "Gene or Genome described as human MIR376C wild-type allele is located in the vicinity of 14q32.31 and is approximately 86 bases in length. This allele, which encodes MIR376C pre-miRNA, plays a role in either transcriptional or translational regulation of target sequences." + }, + { + "input": "Concept: Lilianae (Plant)", + "output": "Plant described as a superorder of flowering plants (Angiosperms) which includes monocotyledonous plants." + }, + { + "input": "Concept: mmr vaccine (Vaccines)", + "output": "Vaccines, Combined described as a trivalent vaccine containing live attenuated viruses that can cause measles, mumps and rubella. It is an injection administered subcutaneously in two separate doses. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C96403\" active clinical trials using this agent." + }, + { + "input": "Concept: Cinchona officinalis homeopathic preparation (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as peruvian bark." + }, + { + "input": "Concept: Phellinus (Fungus)", + "output": "Basidiomycota described as a genus of fungi in the family Hymenochaetaceae, class Hymenochaetales and phylum BASIDIOMYCOTA. Phellinus fungi are basidiomycetes which form large shelf-shaped mushrooms. Phellinus linteus (now Tropicoporus linteus) is a medicinal mushroom which produces compounds such as hispidin, a phenolic compound with antioxidant properties." + }, + { + "input": "Concept: PHYSIOLOGICAL DOMAIN (Omaha System)", + "output": "Omaha System described as functions and processes that maintain life." + }, + { + "input": "Concept: Musculoskeletal chest pain due to rib injury (Sign or Symptom)", + "output": "Musculoskeletal chest pain described as a condition in which there is musculoskeletal chest pain secondary to trauma to one or more ribs." + }, + { + "input": "Concept: acetaldehyde formation (Molecular Function)", + "output": "aldehyde biosynthetic process described as the chemical reactions and pathways resulting in the formation of acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol." + }, + { + "input": "Concept: Link (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as brand of magnesium carbonate and aluminum hydroxide" + }, + { + "input": "Concept: 11: 118471387-118469797 (Spatial Concept)", + "output": "Chromosome 11 Physical Location described as physical location of H2AX_Gene" + }, + { + "input": "Concept: exit from nematode dormancy (exit from diapause)", + "output": "something described as exit from the facultative diapause of the dauer (enduring) larval stage of nematode development." + }, + { + "input": "Concept: rectosigmoid resection (Therapeutic or Preventive Procedure)", + "output": "RECTUM AND ANUS: EXCISIONS described as surgical removal part or all of the sigmoid colon, and part or all of the rectum." + }, + { + "input": "Concept: FACILITY CONTACT BACKUP (Human)", + "output": "Human described as the secondary contact person at a facility." + }, + { + "input": "Concept: Bone structure of lower limb (Bone of limb)", + "output": "Structure of appendicular skeleton described as the bones of the upper and lower LEG. They include the PELVIC BONES." + }, + { + "input": "Concept: cell-cell signaling involved in kidney development (Cell Function)", + "output": "something described as any process that mediates the transfer of information from one cell to another and contributes to the progression of the kidney over time, from its formation to the mature organ." + }, + { + "input": "Concept: 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine (Diaminopyrimidines, antimalarials)", + "output": "Antimalarials described as one of the FOLIC ACID ANTAGONISTS that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis." + }, + { + "input": "Concept: Rabbit Neoplasm (Neoplastic Process)", + "output": "Neoplastic Process described as a neoplasm occurring in a rabbit." + }, + { + "input": "Concept: Nephelometers (Electromechanical Devices)", + "output": "Photometers, Filter described as filter photometers that use a light source that directs the light through a suspension (e.g., containing cells) to a photodetector positioned at an angle from the incident beam to detect only scattered light. Nephelometers can detect particles (e.g., bacteria) in suspension at much lower concentration than is possible using turbidimeters." + }, + { + "input": "Concept: pyrene dioxygenase activity (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)", + "output": "something described as catalysis of the reaction: pyrene + 2 H+ + 2 e- + O2 = cis-4,5-dihydroxy-4,5-dihydropyrene." + }, + { + "input": "Concept: Phosphoprotein 32-Related Protein 2 (Tumor-Related Protein)", + "output": "Biologically Active Substance described as acidic leucine-rich nuclear phosphoprotein 32 family member D (131 aa, ~15 kDa) is encoded by the human ANP32D gene. This protein is involved in tumorigenesis." + }, + { + "input": "Concept: Gingival margin (Bona fide anatomical line)", + "output": "Head and Neck Part described as the crest of the gingiva surrounding a tooth." + }, + { + "input": "Concept: regulation of glycolysis through fructose-6-phosphate (Cell Function)", + "output": "something described as any process that modulates the frequency, rate or extent of glycolytic process through fructose-6-phosphate." + }, + { + "input": "Concept: MSH2/MSH3 complex (Cell Component)", + "output": "something described as a heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3." + }, + { + "input": "Concept: downregulation of metabolic process (regulation of metabolism)", + "output": "negative regulation of biological process described as any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." + }, + { + "input": "Concept: Mind-Body Relation (Mind-Body Therapies)", + "output": "Mental Processes described as the relation between the mind and the body in a religious, social, spiritual, behavioral, and metaphysical context. This concept is significant in the field of alternative medicine. It differs from the relationship between physiologic processes and behavior where the emphasis is on the body's physiology ( = PSYCHOPHYSIOLOGY)." + }, + { + "input": "Concept: bloated feeling (Sensations associated with the digestive system)", + "output": "Sensations associated with the digestive system described as sensation of distension of the stomach or abdomen." + }, + { + "input": "Concept: laminin complex (Cell Component)", + "output": "something described as a large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes." + }, + { + "input": "Concept: Golden Hamster (OTHER DOMESTIC ANIMAL SPECIES)", + "output": "OTHER DOMESTIC ANIMAL SPECIES described as all Syrian hamsters in captivity are derived from a mother and eight pups that were captured in the wild in Aleppo, Syria by Dr. Israel Aharoni in 1930. Syrian Hamsters exhibit multiple coat colors, gold being the most common, and have a life span of about two to three years. Syrian hamsters are extremely territorial and are prone to attacking other hamsters so cannot be housed together under most circumstances. Females come into estrus every four days and embryo gestation is 16-18 days long. Syrian hamsters may exhibit diarrhea, neoplasms, amyloidosis, polycystic disease, and pregnancy-associated toxemia." + }, + { + "input": "Concept: Small epiphyses (Limb structure)", + "output": "Limb structure described as reduction in the size or volume of epiphyses." + }, + { + "input": "Concept: cuticle chitin metabolic process (chitin metabolic process)", + "output": "something described as the chemical reactions and pathways involving cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles." + }, + { + "input": "Concept: downregulation of protein localisation to nucleus (negative regulation of cellular protein localization)", + "output": "regulation of protein localization to nucleus described as any process that stops, prevents or reduces the frequency, rate or extent of protein localization to nucleus." + }, + { + "input": "Concept: Tuberculosis, Avian (Non-human disorder)", + "output": "Mycobacterium Infections, Nontuberculous described as a variety of TUBERCULOSIS affecting various birds, including chickens and ducks. It is caused by MYCOBACTERIUM AVIUM and characterized by tubercles consisting principally of epithelioid cells." + }, + { + "input": "Concept: Models, Computer (Computing Methodologies)", + "output": "Mathematical Model described as the use of computers to perform structural, mathematical or molecular modeling or to simulate real life activities." + }, + { + "input": "Concept: Near Infrared Fluorescence Imaging Probe (Indicator, Reagent, or Diagnostic Aid)", + "output": "Medicinal product acting as imaging agent described as for non-invasive detection, Protease-Activated Near-Infrared Fluorescent Probes are used for in vivo Imaging of tumors in Mice." + }, + { + "input": "Concept: Carcinogenesis, Inhibition (Cancer Prevention)", + "output": "Cancer Prevention described as suppression or prevention of the carcinogenic process/development of cancer." + }, + { + "input": "Concept: Proximal Bile Duct (Anatomy Qualifier)", + "output": "Anatomy Qualifier described as these include the bile ducts which are located at the hilum of the liver as well as the segment where the left and right hepatic ducts join just outside the liver to form the common bile duct." + }, + { + "input": "Concept: INTERLEUKIN 17F (Interleukin Gene)", + "output": "Gene or Genome described as this gene plays a role in the negative regulation of angiogenesis and the stimulation of the production of other cytokines." + }, + { + "input": "Concept: Abnormality of hepatobiliary system physiology (Abnormality of digestive system physiology)", + "output": "something described as a functional anomaly of the hepatobiliary system []" + }, + { + "input": "Concept: 6-(4-Hydroxyphenylazo)uracil (Nucleic Acid, Nucleoside, or Nucleotide)", + "output": "something described as inhibitor of DNA replication in gram-positive bacteria." + }, + { + "input": "Concept: Middle Temporal Gyrus (Temporal lobe gyrus)", + "output": "Gyrus of brain described as a gyrus or ridge on the outer surface of the temporal lobe between the superior and middle temporal sulci." + }, + { + "input": "Concept: Methemoglobin concentration increased above normal (Abnormal hemoglobin finding)", + "output": "Non-Neoplastic Hematologic and Lymphocytic Disorder described as a condition in which a higher-than-normal amount of methemoglobin is found in the blood. Methemoglobin is a form of hemoglobin that cannot carry oxygen. In methemoglobinemia, tissues cannot get enough oxygen. Symptoms may include headache, dizziness, fatigue, shortness of breath, nausea, vomiting, rapid heartbeat, loss of muscle coordination, and blue-colored skin. Methemoglobinemia can be caused by injury or being exposed to certain drugs, chemicals, or foods. It can also be an inherited condition." + }, + { + "input": "Concept: Principal body part subdivision (Body Location or Region)", + "output": "Body part described as anatomical structure, which is a subdivision of a body part; it may exclude bones; is demarcated from other subdivisions of the same body part by anatomical surfaces or lines or topographical references; together with other contiguous body part subdivisions, it constitutes a body part. Examples: thorax, perineum, back of neck, forearm, hand, phalanx, nose, auricle of ear, scrotum." + }, + { + "input": "Concept: Cylindrical Refraction Error (Diagnostic Procedure)", + "output": "something described as a measurement of the extent of defect in vision caused by a mismatch of optical power between the cylindrical and horizontal meridians, resulting in sub-optimal reflection of light onto the retina." + }, + { + "input": "Concept: urinal (Reusable Devices)", + "output": "Medical Device described as devices consisting of containers or fixtures that are designed to collect and that may hold urine. Urinals intended for use in healthcare are typically handheld portable containers with appropriate openings for direct urination. These urinals are made of plastic (for single patient use) or made of glass or metal (reusable); the shape may be conformed for use by people of any sex (i.e., unisex) or for use only by males or females. Some urinals include attached lids and/or other devices to prevent spills. Portable urinals are used mainly by bedridden patients and people with disabilities or incontinence. Other urinals intended for use in bathrooms may resemble small toilets to be used while sitting on them or, more frequently, fixtures attached to the walls for urination while standing (mainly intended for male users). Some wall-installed urinals may be used by several people simultaneously." + }, + { + "input": "Concept: kanamycin anabolism (aminoglycoside antibiotic biosynthetic process)", + "output": "kanamycin metabolic process described as the chemical reactions and pathways resulting in the formation of kanamycin." + }, + { + "input": "Concept: Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma (Intestinal T-Cell Lymphoma)", + "output": "Mature (peripheral) T-cell neoplasm described as a mature T-cell and NK-cell non-Hodgkin lymphoma of intraepithelial T-lymphocytes. It usually arises from the small intestine. A minority of cases arise from the large intestine or the stomach. It is characterized by the presence of a monomorphic cellular infiltrate of small to medium-sized T-lymphocytes that are cytotoxic and express CD56. It is not associated with celiac disease." + }, + { + "input": "Concept: Ulnar arterial branch (Arteries)", + "output": "Artery of upper extremity described as any artery arising from the ulnar artery." + }, + { + "input": "Concept: ALTID (Intellectual Product)", + "output": "Identifier described as a backup sequence of characters used to identify a study." + }, + { + "input": "Concept: Caries into Dentin (Dental caries)", + "output": "something described as tooth decay that extends through the enamel into the dentin layer." + }, + { + "input": "Concept: ERYTHEMA INDURATUM (INFLAMMATORY DISEASES OF THE SUBCUTANEOUS FAT AND NONINFECTIOUS GRANULOMAS)", + "output": "Mucous membrane erythema described as a type of panniculitis characterized histologically by the presence of granulomas, vasculitis, and necrosis. It is traditionally considered to be the tuberculous counterpart of nodular vasculitis, but is now known to occur without tuberculous precedent. It is seen most commonly in adolescent and menopausal women, is initiated or exacerbated by cold weather, and typically presents as one or more recurrent erythrocyanotic nodules or plaques on the calves. The nodules may progress to form indurations, ulcerations, and scars." + }, + { + "input": "Concept: repeatQuantity (Quantity)", + "output": "Quantity described as the number of times something occurs." + }, + { + "input": "Concept: Gumweed (Asteraceae)", + "output": "North American clade described as a plant genus of the family ASTERACEAE. Members contain triterpenoid sapogenins." + }, + { + "input": "Concept: Grade 1 Dry Eye, CTCAE (Dry Eye, CTCAE)", + "output": "Finding described as asymptomatic; clinical or diagnostic observations only; symptoms relieved by lubricants" + }, + { + "input": "Concept: Iodinated Contrast Agent (Contrast Media)", + "output": "Contrast Media described as a contrast agent containing an iodine-based dye used in many diagnostic imaging examinations, including computed tomography, angiography, and myelography. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28500\" active clinical trials using this agent." + }, + { + "input": "Concept: Residual Tumor Stage R0 (Intellectual Product)", + "output": "Residual tumor stage finding described as complete resection, margins histologically negative, no residual tumor left after resection" + }, + { + "input": "Concept: kg*sec/mL (Measurement Unit Description)", + "output": "Quantitative Concept described as seconds times kilograms per milliliter." + }, + { + "input": "Concept: Visceral Pleura (Pleural part)", + "output": "Body Part, Organ, or Organ Component described as visceral serous membrane which is continuous with the parietal pleura and is attached to the parenchyma of lobe of lung." + }, + { + "input": "Concept: Scavenger, Free Radical (Chemical Viewed Functionally)", + "output": "something described as class of compounds which oxidize, reduce, combine with, or catalyze reactions of radicals; used to probe chemical reaction mechanisms, to verify free radical effects on biological systems, and experimentally as chemopreventives for free radical toxicity in vivo." + }, + { + "input": "Concept: Household ventilator (Ventilator - respiratory equipment)", + "output": "Ventilator - respiratory equipment described as ventilators designed to provide support to patients who do not require complex critical care ventilators. Most devices use positive pressure to deliver gas to the lungs at normal breathing rates and tidal volumes through an endotracheal tube, a tracheostomy cannula, or a mask, typically when ventilation is needed only at night. These ventilators include a control system and alarms; some ventilators also include oxygen accumulators and heating and humidifying capabilities. Portable/home care ventilators may use several methods of cycling (e.g., volume, time) and several ventilation modes, including control, assist/control, and synchronized intermittent mandatory ventilation (SIMV) modes. Power is typically supplied from a power line or from an internal or external battery (e.g., a car battery). These ventilators are small, lightweight, and easy to operate, should resist tipping over, and be easily mounted in different orientations; ventilator alarms should allow quick assessment and correction of the alarm condition. Portable/home care ventilators are used for long-term ventilatory support in extended care facilities and in the home; they may also be used in emergency care." + }, + { + "input": "Concept: mitochondrial protein processing (Post-Translational Protein Processing)", + "output": "cellular protein metabolic process described as the peptide cleavage of mitochondrial proteins, including cleavage contributing to their import." + }, + { + "input": "Concept: Rats, Inbred CDF (Common Rattus Norvegicus Strains)", + "output": "something described as an inbred strain of rat that is used for general BIOMEDICAL RESEARCH purposes." + }, + { + "input": "Concept: DARPP (dopamine)", + "output": "dopamine described as dopamine and cyclic AMP regulated phosphoproteins." + }, + { + "input": "Concept: Entire trochanteric section of femur (Bone structure of proximal femur)", + "output": "Structure of trochanteric section of femur described as the bony region in the proximal portion of the femur between the greater, lesser and sub- (also called the third) trochanters." + }, + { + "input": "Concept: Optic neuritis, NOS (Disease or Syndrome)", + "output": "Increased inflammatory response described as inflammation of the second cranial nerve or optic nerve; commonly associated conditions include autoimmune disorders such as multiple sclerosis, infections, and granulomatous diseases." + }, + { + "input": "Concept: Sarcoma of the Orbit pT1 TNM Finding v7 (Sarcoma of the Orbit Pathologic Primary Tumor TNM Finding v7)", + "output": "Sarcoma of the Orbit Pathologic Primary Tumor TNM Finding v7 described as sarcoma of the orbit with tumor measuring 15 mm or less in greatest dimension." + }, + { + "input": "Concept: COMPONENTS, EXERCISE (Medical Device)", + "output": "something described as an exercise component is a device that is used in conjunction with other forms of exercise and that is intended for medical purposes, such as to redevelope muscles or restore motion to joints or for use as an adjunct treatment for obesity. Examples include weights, dumbbells, straps, and adaptive hand mitts." + }, + { + "input": "Concept: Inositol Hexakisphosphate Kinase 1 wt Allele (IP6K1 gene)", + "output": "Gene or Genome described as human IP6K1 wild-type allele is located in the vicinity of 3p21.31 and is approximately 62 kb in length. This allele, which encodes inositol hexakisphosphate kinase 1 protein, plays a role in inositol phosphate metabolism." + }, + { + "input": "Concept: RNA binding motif protein 15 (Gene or Genome)", + "output": "Gene or Genome described as this gene plays a role in RNA binding." + }, + { + "input": "Concept: Grade 4 Esophageal necrosis (Finding)", + "output": "Finding described as life-threatening consequences; urgent operative intervention indicated" + }, + { + "input": "Concept: Satellite DNAs (Nucleic Acid, Nucleoside, or Nucleotide)", + "output": "Biologically Active Substance described as highly repetitive DNA sequences found in HETEROCHROMATIN, mainly near centromeres. They are composed of simple sequences (very short) (see MINISATELLITE REPEATS) repeated in tandem many times to form large blocks of sequence. Additionally, following the accumulation of mutations, these blocks of repeats have been repeated in tandem themselves. The degree of repetition is on the order of 1000 to 10 million at each locus. Loci are few, usually one or two per chromosome. They were called satellites since in density gradients, they often sediment as distinct, satellite bands separate from the bulk of genomic DNA owing to a distinct BASE COMPOSITION." + }, + { + "input": "Concept: Tubes, Tracheal, One-Lung Ventilation, Double Lumen, Video (Tubes, Tracheal, One-Lung Ventilation, Double Lumen)", + "output": "something described as one-lung ventilation tracheal tubes designed as a double-lumen tube with a video camera attached at the distal tip to facilitate visualization during the procedures. These tubes consist of a disposable plastic (e.g., PVC) sterilized double-lumen tube that includes a video system (i.e., camera, light source, and fiberoptic cable), a cuff, and an integral flushing system to clean the camera lenses. The tracheal tube also permits passing a catheter to block the airway at the selected bronchial site. Double-lumen video tracheal tubes are intended for continuous visualization of the vocal cords, trachea, and carina while performing the procedures; they permit the observation of the procedures on external monitors (including handheld devices) linked to an external unit that is connected with cables to the proximal end of the tubes. The tubes are used mainly for intubation, during thoracic surgery requiring lung isolation, and/or for other intensive care procedures reducing the need of bronchoscopes to perform the procedures." + }, + { + "input": "Concept: Organizations (Professional Organization or Group)", + "output": "social group and organization described as organizational unit like a laboratory, institute or consortium." + }, + { + "input": "Concept: Location transfer assessment (Common nursing interventions)", + "output": "something described as assessing a patient's need to be transferred from one location to another." + }, + { + "input": "Concept: SLAC complex (Cell Component)", + "output": "protein-containing complex described as a protein complex that regulates Arp2/3 complex-mediated actin nucleation." + }, + { + "input": "Concept: Estimated intake of pantothenic acid in 24 hours (Quantitative Concept)", + "output": "Pantothenic acid intake described as the approximate intake in one day of pantothenic acid." + }, + { + "input": "Concept: ESTABLISHMENT ACTIVITY (FDA Quality Metrics Terminology)", + "output": "FDA Quality Metrics Terminology described as terminology used in the framework of identifying types of establishment activities." + }, + { + "input": "Concept: Decreased proportion of naive thymus-derived, alpha-beta T cells (Abnormal proportion of naive T cells)", + "output": "Finding described as an abnormally decreased proportion of naive T cells relative to the total number of T cells." + }, + { + "input": "Concept: Ethosuximid (Succinimides)", + "output": "Pharmacologic Substance described as a succinimide with anticonvulsant activity. The exact mechanism of action is not entirely understood, but most likely ethosuximide exerts its effects by partial antagonism of T-type calcium channels of the thalamic neurons. This leads to a decrease in burst firing of thalamocortical neurons, which stabilizes the nerve activity in the brain and prevents seizures. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47523\" active clinical trials using this agent." + }, + { + "input": "Concept: PANSS1-Passive/Apathetic Social Withdraw (Intellectual Product)", + "output": "PANSS Clinical Classification Question described as positive and Negative Syndrome Scale (PANSS) Temperature - Passive or apathetic social withdrawal." + }, + { + "input": "Concept: Huang Lian preparation (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as a Chinese herb that has been used as a treatment for a variety of medical problems. It is being studied as an anticancer drug." + }, + { + "input": "Concept: Stage III (Ann Arbor lymphoma staging system)", + "output": "Intellectual Product described as a clinical stage that refers to lymphoma involving node regions on both sides of the diaphragm, or an extralymphatic organ or site plus nodes on both sides of the diaphragm (IIIe), or lymph nodes on both sides of the diaphragm plus spleen (IIIs)." + }, + { + "input": "Concept: METHOXAMINE (Phenethylamines)", + "output": "Adrenergic alpha-Agonists described as an alpha-1 adrenergic agonist that causes prolonged peripheral VASOCONSTRICTION." + }, + { + "input": "Concept: Suicidal Risk Monitoring (Risk Based Monitoring)", + "output": "Risk Based Monitoring described as a systematic approach to identify and assess the risks of participant suicidal ideation and/or suicide." + }, + { + "input": "Concept: oogenesis, establishment and maintenance of oocyte localization (localization of cell)", + "output": "localization of cell described as directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." + }, + { + "input": "Concept: KRAS c.35 36delGTinsAG (KRAS Exon 2 Mutation)", + "output": "Cell or Molecular Dysfunction described as a complex substitution where the nucleotide sequence at positions 35 through 36 of the coding sequence of the KRAS gene has changed from guanine-thymine to adenine-guanine." + }, + { + "input": "Concept: Agents, Radiation Sensitizing (Physiological Effects of Drugs)", + "output": "Antineoplastic Agents described as drugs used to potentiate the effectiveness of radiation therapy in destroying unwanted cells." + }, + { + "input": "Concept: RMNTLP (Protein or Enzyme Type Measurement)", + "output": "Protein or Enzyme Type Measurement described as a measurement of the remnant lipoproteins in a biological specimen." + }, + { + "input": "Concept: Predominantly Diffuse Follicular Lymphoma with 1p36 Deletion (Lymphoma, Follicular)", + "output": "Neoplastic Process described as a predominantly diffuse, low-grade follicular lymphoma. It often presents as a large localized inguinal mass, lacks BCL2 rearrangement, and is associated with 1p36 deletion." + }, + { + "input": "Concept: CDISC Clinical Classification AVPU Test Name Terminology (CDISC Clinical Classification Terminology)", + "output": "something described as alert Verbal Painful Unresponsive Scale test name." + }, + { + "input": "Concept: PerformedImagingStudy.imagingAccessionIdentifier (Intellectual Product)", + "output": "something described as an order filler system-generated identifier for the order for the imaging study. EXAMPLE(S): OTHER NAME(S): NOTE(S):" + }, + { + "input": "Concept: VZOW (Quantitative Concept)", + "output": "Observed Volume of Distribution described as the volume of distribution associated with the terminal slope following intravascular administration, calculated using the observed value of the last non-zero concentration, divided by the weight." + }, + { + "input": "Concept: Lugano Stage (Disease Stage Qualifier)", + "output": "Classification described as an adult non-Hodgkin lymphoma and adult and childhood Hodgkin lymphoma stage defined according to the Lugano classification criteria." + }, + { + "input": "Concept: CDISC ADAS-Cog - Ideational Praxis: Insert (ADAS-Cog CDISC Version Questionnaire Question)", + "output": "Intellectual Product described as alzheimer's Disease Assessment Scale-Cognitive CDISC Version - Ideational praxis task for put the paper in the envelop." + }, + { + "input": "Concept: Animal.speciesCode (Intellectual Product)", + "output": "Species Code described as a coded value specifying one of the basic units of biological classification and taxonomic rank that specifies a group of organisms that share similar characteristics and can interbreed with one another to produce fertile offspring." + }, + { + "input": "Concept: Interventional Study Protocol Version Control Type Code (Intellectual Product)", + "output": "something described as a coded value specifying the kind of comparison or comparator against which the study treatment is evaluated. EXAMPLE(S): placebo, active, historical, uncontrolled, dose comparison OTHER NAME(S): NOTE(S):" + }, + { + "input": "Concept: Juvenile literature (Intellectual Product)", + "output": "Popular Work described as works produced for children through age 15 or through the ninth grade." + }, + { + "input": "Concept: negative regulation of triacylglycerol catabolic process (regulation of triglyceride catabolic process)", + "output": "regulation of triglyceride catabolic process described as any process that decreases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride." + }, + { + "input": "Concept: Spindle- and Kinetochore-Associated Protein 2 (Cell Cycle Proteins)", + "output": "Cell Cycle Proteins described as spindle and kinetochore-associated protein 2 (121 aa, ~14 kDa) is encoded by the human SKA2 gene. This protein plays a role in both chromosome segregation and microtubule binding." + }, + { + "input": "Concept: Thrombectomy Embolectomy Catheters (Medical Device)", + "output": "Vascular Catheters described as an embolectomy catheter is a balloon-tipped catheter that is used to remove thromboemboli, i.e., blood clots which have migrated in blood vessels from one site in the vascular tree to another." + }, + { + "input": "Concept: Urethral Cancer TNM Finding v8 (Urinary Tract Cancer TNM Finding v8)", + "output": "something described as a finding about one or more characteristics of urethral cancer, following the rules of the TNM AJCC v8 classification system. This classification system applies to urothelial (transitional cell), squamous, and glandular carcinomas of the urethra and to urothelial (transitional cell) carcinomas of the prostate and prostatic urethra. It does not apply to squamous cell carcinomas of the penile foreskin (are staged according to the classification for penis), primary urothelial carcinomas of the bladder with transmural involvement of the prostate (are staged according to the classification for urinary bladder), prostatic adenocarcinomas (are staged according to the classification for prostate), mucosal melanomas of the urethra (no AJCC staging system), lymphomas (are staged according to the classification for Hodgkin and non-Hodgkin lymphoma), and sarcomas (are staged according to the classification for soft tissue sarcoma of the abdomen and thoracic visceral organs)." + }, + { + "input": "Concept: histone-serine kinase activity (histone kinase activity)", + "output": "histone kinase activity described as catalysis of the transfer of a phosphate group to a serine residue of a histone. Histones are any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes." + }, + { + "input": "Concept: monoblastic leukemia, adult acute (Adult Acute Monoblastic and Monocytic Leukemia)", + "output": "Acute monoblastic leukemia described as an acute monoblastic leukemia occurring in adults." + }, + { + "input": "Concept: Bulbus (Auditory pathway structure)", + "output": "Brain part described as organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures. Examples: There is only one medulla oblongata." + }, + { + "input": "Concept: PDE2A wt Allele (PDE2A gene)", + "output": "Gene or Genome described as human PDE2A wild-type allele is located in the vicinity of 11q13.4 and is approximately 98 kb in length. This allele, which encodes cGMP-dependent 3',5'-cyclic phosphodiesterase protein, plays a role in the metabolism of both cyclic AMP and cyclic GMP." + }, + { + "input": "Concept: CDISC Questionnaire SGRQ-C Test Name Terminology (Intellectual Product)", + "output": "CDISC Questionnaire Terminology described as test names of questionnaire questions associated with the St.George's Respiratory Questionnaire for COPD Patients (SGRQ-C) for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: Dye-dilution cardiac output unit (Cardiac output unit)", + "output": "Cardiovascular equipment described as cardiac output units that measures the blood flow from the heart using the indicator dilution technique in which a dye is injected upstream of the heart by a balloon-tipped (flow directed) catheter and monitored on the downstream side. These devices consist of a dye-dilution catheter used to inject a bolus of dye (e.g., lidocaine); a densitometer to determine the dye concentration, typically from a sample in a peripheral artery; and an electronic unit to process and display the results." + }, + { + "input": "Concept: Otic Solution Dosage Form (Otic dosage form)", + "output": "Solution Dosage Form described as a solution intended for administration either on the outer ear or into the auditory canal." + }, + { + "input": "Concept: Enlarged lateral fissure (Dilated ventricles)", + "output": "Dilated ventricles described as an increase in size of the subarachnoid space associated with the lateral cerebral sulcus (Sylvian fissure)." + }, + { + "input": "Concept: Proportion of energy requirement from protein and protein derivatives in 24 hours (Quantitative Concept)", + "output": "Quantitative Concept described as the portion of total estimated energy need in one day to be derived from protein." + }, + { + "input": "Concept: 3-methylglutaconic aciduria type VII (Autosomal recessive hereditary disorder)", + "output": "something described as a rare disorder with characteristics of neurological problems and neutropenia. Onset of symptoms is in early childhood and severity varies widely among affected individuals. In the most severely affected individuals, features are apparent in infancy and sometimes at birth. Associated with congenital cataracts or cataracts in infancy. The disease is caused by mutations in the CLPB gene which is likely to reduce or eliminate the amount of functional CLPB protein. The severity of the disease may be related to the amount of functional protein that remains. Inherited in an autosomal recessive pattern." + }, + { + "input": "Concept: substantia nigra, compact part (Brain part)", + "output": "Body Part, Organ, or Organ Component described as a part of the substantia nigra. The pars compacta nerve cells contain melanin and are involved in motor control." + }, + { + "input": "Concept: Renal vascular disorder (Renal vascular disorders NEC)", + "output": "Kidney Diseases described as a kidney disorder that results from the damage of the renal arteries or veins. It may lead to renal dysfunction and/or hypertension." + }, + { + "input": "Concept: Bone of Face (Maxillofacial bone structure)", + "output": "Bones of cranium and face described as bones that constitute the facial part of the skull, including the hyoid, palatine, zygomatic, mandible, and maxilla; may also include lacrimal and nasal bones, inferior nasal concha and vomer." + }, + { + "input": "Concept: positive regulation of histone H2B conserved C-terminal lysine ubiquitination (Genetic Function)", + "output": "positive regulation of histone H2B ubiquitination described as any process that activates or increases the frequency, rate or extent of histone H2B conserved C-terminal lysine ubiquitination." + }, + { + "input": "Concept: Stickler Syndrome Gene Panel Reagents (Medical Device)", + "output": "Medical Device described as molecular assay reagents intended to identify genetic variants associated with Stickler syndrome, a multisystem disorder that causes vision, hearing, and joint problems and is characterized by distinctive facial appearance related to abnormal development of bones in the middle of the face. Genetic variants at multiple loci have been associated with Stickler syndrome. These reagents are intended to detect various types of genetic changes (e.g., deletions, duplications, insertions, single nucleotide polymorphisms) in multiple Stickler syndrome-associated loci simultaneously." + }, + { + "input": "Concept: Clamps, Dental, Rubber Dam (Dental equipment and devices)", + "output": "Clamp described as a rubber dam and accessories is a device composed of a thin sheet of latex with a hole in the center intended to isolate a tooth from fluids in the mouth duing dental procedures, such as filling a cavity preparation. The device is stretched around a tooth by inserting the tooth through the hole in the center. The device includes the rubber dam, rubber dam clamp, rubber dam frame, and forceps for a rubber dam clamp." + }, + { + "input": "Concept: Muscle eye brain disease with bilateral multicystic leukodystrophy (Hereditary degenerative disease of central nervous system)", + "output": "Eye Abnormalities described as a rare genetic congenital muscular alpha-dystroglycanopathy with brain and eye anomalies. The disorder has characteristics of a severe muscle-eye-brain disease-like phenotype associated with intellectual disability, muscular dystrophy, macrocephaly and extended bilateral multicystic white matter disease. There is evidence the disease is caused by homozygous mutation in the DAG1 gene on chromosome 3p21." + }, + { + "input": "Concept: GluT 1 Glutamate Transporter (Biologically Active Substance)", + "output": "Biologically Active Substance described as excitatory amino acid transporter 2 (574 aa, ~62 kDa) is encoded by the human SLC1A2 gene. This protein plays a role in the mediation of amino acid transport and the attenuation of synaptic signaling." + }, + { + "input": "Concept: Schizophyllums (Basidiomycota)", + "output": "Basidiomycota described as any fungal organism that is not assigned to the species level but can be assigned to the Schizophyllum genus level." + }, + { + "input": "Concept: Hydrogenations (Biochemical Processes)", + "output": "Organic Chemistry Phenomena described as the addition of two hydrogen atoms to another molecular entity through the reaction of molecular hydrogen (H2) with that entity." + }, + { + "input": "Concept: EOR02-Have You Felt Nauseated (Intellectual Product)", + "output": "Intellectual Product described as european Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire - Palliative Care Version 1.0 (EORTC QLQ-C15-PAL Version 1) During the past week: Have you felt nauseated?" + }, + { + "input": "Concept: SEC (Amino Acid, Peptide, or Protein)", + "output": "something described as the biotoxin Staphylococcal enterotoxin C." + }, + { + "input": "Concept: Anti-Idiotype Specified Monoclonal Antibody (Anti-Idiotype Vaccine)", + "output": "something described as a synthetic antibody produced by a genetically homogenous population of hybrid cells (hybridoma) against determinant idiotypes (Id) which usually mimic human epitopes. Anti-Id vaccines may be effective in the treatment of B-cell lymphomas, resulting in tumor regression. Anti-idiotype vaccine therapy is less likely to induce autoimmunity if the target antigen is not normally expressed on normal tissues. Monoclonal antibodies have become powerful tools for tumor targeting, recognizing different protein markers on certain cancer cells and may be used alone or as delivery agents for drugs, toxins or radioactive material targeted to tumors." + }, + { + "input": "Concept: HMG Protein (Biologically Active Substance)", + "output": "Amino Acid, Peptide, or Protein described as the High Mobility Group (HMG) proteins were originally isolated from mammalian cells, named according to their electrophoretic mobility in polyacrylamide gels, and were arbitrarily classed as a specific type of non-histone proteins based on the observation that they are ubiquitous to mammalian cells, that they share certain physical properties, and that they are associated with isolated chromatin. Those mammalian proteins considered to be Canonical HMG proteins are now subdivided into 3 superfamilies: the HMGB (formerly HMG-1/-2) family, the HMGN (formerly HMG-14/-17) family, and the HMGA (formerly HMG-I/Y/C) family. Each HMG family has a characteristic functional sequence motif." + }, + { + "input": "Concept: Small end part of pinkie finger bone (Anatomical Abnormality)", + "output": "Abnormality of the epiphyses of the 5th finger described as abnormally small size of the epiphyses of the 5th finger with respect to age-dependent norms." + }, + { + "input": "Concept: PedsQL Neuromuscular Module Acute Version 3.0 Young Child Report - Get Hurt Accidentally (Intellectual Product)", + "output": "Intellectual Product described as pediatric Quality of Life Neuromuscular Module Acute Version 3 Young Child - Think about how you have been doing for the past 7 days. Please listen carefully to each sentence and tell me how much of a problem this is for you: I get hurt accidentally." + }, + { + "input": "Concept: Oxidation-Reduction (Molecular Function)", + "output": "chemical reaction described as chemical reaction in which electrons are transferred from one reactant to another." + }, + { + "input": "Concept: DNA integrity checkpoint (Cell Cycle Checkpoints)", + "output": "Cell Cycle Checkpoints described as a cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes." + }, + { + "input": "Concept: negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation (negative regulation of multicellular organismal process)", + "output": "negative regulation of fibroblast growth factor receptor signaling pathway described as any process that stops, prevents or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation." + }, + { + "input": "Concept: Crystals (Crystal Growth Measurement)", + "output": "Laboratory Procedure described as a statement that indicates crystals were looked for in a biological specimen." + }, + { + "input": "Concept: Have Nausea Continually (Intellectual Product)", + "output": "something described as a response indicating that an individual has or had nausea continually." + }, + { + "input": "Concept: negative regulation of N6-dimethylallyladenine:acceptor oxidoreductase activity (negative regulation of oxidoreductase activity)", + "output": "something described as any process that stops, prevents or reduces the frequency, rate or extent of cytokinin dehydrogenase activity." + }, + { + "input": "Concept: erythrosine (Food Coloring Agents)", + "output": "E [Preparations] described as a tetraiodofluorescein used as a red coloring in some foods (cherries, fish), as a disclosure of DENTAL PLAQUE, and as a stain of some cell types. It has structural similarity to THYROXINE." + }, + { + "input": "Concept: MACULOPAPULAR RASH (Rashes, eruptions and exanthems NEC)", + "output": "Erythema described as a skin rash that is characterized by diffuse cutaneous erythema with areas of skin elevation. It may evolve to vesicles or papules as part of a more severe clinical entity. Different degrees of angioedema with involvement of subcutaneous tissue may also appear." + }, + { + "input": "Concept: regulation of metanephric glomerulus development (Organ or Tissue Function)", + "output": "regulation of glomerulus development described as any process that modulates the rate, frequency or extent of metanephric glomerulus development, the progression of the metanephric glomerulus over time from its initial formation until its mature state. The metanephric glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney, or metanephros." + }, + { + "input": "Concept: Double-Walled Nanotube (Nanotubes, Carbon)", + "output": "something described as a carbon nanotube comprised of two layers of graphitic carbon." + }, + { + "input": "Concept: 3+ PVR Staining (Laboratory or Test Result)", + "output": "Poliovirus Receptor Staining Finding described as a finding of 3+ staining for poliovirus receptor in a sample." + }, + { + "input": "Concept: cellular response to strigolactone (response to strigolactone)", + "output": "cellular response to lipid described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a strigolactone stimulus." + }, + { + "input": "Concept: NPI1L10 (NPI Questionnaire Question)", + "output": "NPI Questionnaire Question described as neuropsychiatric Inventory (NPI) Severity of the changes in eating habits or appetite." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, PXMP3 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)", + "output": "something described as molecular assay reagents intended to identify mutations in the peroxisomal membrane protein 3, 35kDa (PXMP3) gene, located at chromosome 8q21.1, which encodes for a protein required for peroxisome biogenesis. The protein is thought to be involved in peroxisomal matrix protein import. This genetic mutation has been identified in patients with Zellweger syndrome spectrum, including three well-differentiated forms: Zellweger syndrome (ZS), neonatal adrenoleukodystrophy (NALD), and infantile Refsum's disease (IRD)." + }, + { + "input": "Concept: Mouse CGAP (Cancer Genome Anatomy Project)", + "output": "Research Activity described as similar to the human CGAP. The overall goals of the m-CGAP are: a comparative assessment of mouse cancer stages with those of cognate human cancers, both to validate the mouse models and to promote crossfeeding in the identification of genes that characterize those cancers; the discovery of new genes and gene pathways involved in the stages of carcinogenesis." + }, + { + "input": "Concept: Posterior Myocardial Infarction by ECG Finding (Electrocardiogram: myocardial infarction)", + "output": "something described as an electrocardiographic finding in leads V1 or V2 of an initial R wave duration greater than or equal to 40 ms, R wave greater than S wave, and upright T wave, which is suggestive of myocardial infarction of the posterior wall of the left ventricle. Evidence of inferior or lateral myocardial infarction is usually also present." + }, + { + "input": "Concept: Throat (Body Part, Organ, or Organ Component)", + "output": "Head and Neck Part described as the narrow passage from the mouth to the cavity at the back of the mouth." + }, + { + "input": "Concept: Class II Genes (Gene or Genome)", + "output": "Gene or Genome described as genetic loci in the vertebrate major histocompatibility complex that encode polymorphic products which control the immune response to specific antigens. The genes are found in the HLA-D region in humans and include H-2M, I-A, and I-E loci in mice." + }, + { + "input": "Concept: Findings About Events or Interventions Baseline Flag (Baseline Flag)", + "output": "Functional Concept described as an indication or description that a finding about an event or intervention is a baseline value." + }, + { + "input": "Concept: Mechanical Hand Prostheses (Medical Device)", + "output": "Medical Device described as an external limb prosthetic component is a device intended for medical purposes that, when put together with other appropriate components, constitutes a total prosthesis. Examples of external limb prosthetic components include the following: Ankle, foot, hip, knee, and socket components; mechanical or powered hand, hook, wrist unit, elbow joint, and shoulder joint components; and cable and prosthesis suction valves." + }, + { + "input": "Concept: Chromatin Structure (Cell Component)", + "output": "something described as the more readily stainable portion of the cell nucleus, forming a network of nuclear fibrils within the achromatin of a cell. It is a deoxyribonucleic acid attached to a protein (primarily histone) structure base and is the carrier of genes in inheritance. It occurs in two states, euchromatin and heterochromatin, with different staining properties, and during cell division, it coils and folds to form the chromosomes." + }, + { + "input": "Concept: positive regulation of inner ear receptor cell differentiation (positive regulation of mechanoreceptor differentiation)", + "output": "regulation of inner ear receptor cell differentiation described as any process that activates or increases the frequency, rate or extent of inner ear receptor cell differentiation." + }, + { + "input": "Concept: ACROKERATOSIS VERRUCIFORMIS (Congenital anomaly of integument)", + "output": "Autosomal dominant hereditary disorder described as a rare genetic skin keratinization disorder with an autosomal dominant mode of inheritance. It is characterized by numerous flesh-colored warty papules on the back of the hands, medial aspect of the feet, knees, and elbows." + }, + { + "input": "Concept: Has Free Acid Or Base Form (NCI Thesaurus Association)", + "output": "Idea or Concept described as used to associate the salt form of a drug with its free acid or free base." + }, + { + "input": "Concept: Occlusion Crossing Vascular Catheters (Vascular Catheters)", + "output": "Vascular Catheters described as vascular catheters designed for use in crossing through chronic total occlusions (CTO) in the vasculature (usually the arteries) using high-frequency mechanical vibrations. These devices consist of a catheter with appropriate dimensions (i.e., diameter and length) according to the artery and/or location of the occlusion. They typically include a core wire that transmits the mechanical vibrations to the tip of the catheter and irrigation capabilities. The catheters are components of vascular occlusion crossing systems that also include a high frequency generator, transducers, and irrigation injectors. Occlusion crossing vascular catheters are mainly intended to facilitate guidewire passage across the CTO, permitting subsequent angioplasty procedures and/or stent placement. Dedicated catheters are available according to the vessel where they are used such as the coronary and peripheral arteries." + }, + { + "input": "Concept: Myofilamentum tenue (Sarcomeres)", + "output": "Cell Component described as filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils." + }, + { + "input": "Concept: 8-oxo-GDP phosphatase activity (Molecular Function)", + "output": "nucleoside-diphosphatase activity described as catalysis of the reaction 8-oxo-GDP + H2O = 8-oxo-GMP + phosphate." + }, + { + "input": "Concept: Ventricular Wall of the Heart (Tissue)", + "output": "something described as the tissue layers that form the cardiac ventricle. They include the endocardium, myocardium and pericardium." + }, + { + "input": "Concept: MNSI1-Left Foot Deformities (Intellectual Product)", + "output": "MNSI Questionnaire Question described as michigan Neuropathy Screening Instrument - Physical Assessment: Appearance of left foot - deformities." + }, + { + "input": "Concept: 5,7 Dihydroxytryptamine (Dihydroxytryptamines)", + "output": "Dihydroxytryptamines described as tryptamine substituted with two hydroxyl groups in positions 5 and 7. It is a neurotoxic serotonin analog that destroys serotonergic neurons preferentially and is used in neuropharmacology as a tool." + }, + { + "input": "Concept: cellular response to sucrose stimulus (cellular response to disaccharide stimulus)", + "output": "Cell Function described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." + }, + { + "input": "Concept: Chromosome Aberrations (Mutation)", + "output": "Pathologic Processes described as an irregularity in the number or structure of chromosomes, usually in the form of a gain (duplication), loss (deletion), exchange (translocation), or alteration in sequence (inversion) of genetic material." + }, + { + "input": "Concept: response to trichodermin (response to ether)", + "output": "response to ether described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichodermin stimulus." + }, + { + "input": "Concept: magnetic black (Ferrous Compounds)", + "output": "Pharmacologic Substance described as iron (II,III) oxide (Fe3O4). It is a black ore of IRON that forms opaque crystals and exerts strong magnetism." + }, + { + "input": "Concept: Elevated plasma cell count (Abnormal plasma cell count)", + "output": "something described as an abnormally high number of plasma cells in the blood circulation. Plasma cells are the the effector cells dedicated to the production of a high amount of antibodies. []" + }, + { + "input": "Concept: menstruation; infrequent (Absent, scanty and rare menstruation)", + "output": "Absent, scanty and rare menstruation described as infrequent menstrual periods." + }, + { + "input": "Concept: Facial Recognition, Automated (Biometric Identification)", + "output": "something described as electronic identification of a human based on attributes of the face." + }, + { + "input": "Concept: SMARCE1 Gene (SWI/SNF-Related Gene)", + "output": "SWI/SNF-Related Gene described as this gene is involved in chromatin remodeling and regulation of transcription." + }, + { + "input": "Concept: MELOGLIPTIN (Dipeptidyl Peptidase-4 Inhibitor)", + "output": "something described as a potent, selective and orally bioavailable, cyanopyrrolidine-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity." + }, + { + "input": "Concept: Dihydro-Orotate Amidohydrolase (Hydrolase)", + "output": "Hydrolase described as an enzyme that, in the course of pyrimidine biosynthesis, catalyzes ring closure by removal of water from N-carbamoylaspartate to yield dihydro-orotic acid. EC 3.5.2.3." + }, + { + "input": "Concept: Glomerular Filtration Rate from Creatinine Adjusted for BSA (Laboratory Procedure)", + "output": "something described as an estimation of the glomerular filtration rate adjusted for body surface area based on creatinine." + }, + { + "input": "Concept: Stepper Motor (Device Motor)", + "output": "Device Motor described as a motor designed to rotate in fixed increments." + }, + { + "input": "Concept: Dickkopf WNT Signaling Path Inhibitor 1 Measurement (Protein or Enzyme Type Measurement)", + "output": "something described as the determination of the amount of dickkopf WNT signaling pathway inhibitor 1 present in a sample." + }, + { + "input": "Concept: Epstein-Barr Nuclear Antigen 1 IgG Ab Measurement (Immunologic Tests)", + "output": "something described as the determination of the amount of the Epstein-Barr nuclear antigen 1 IgG antibody present in a sample." + }, + { + "input": "Concept: distal (type I) renal tubular acidosis (Disease or Syndrome)", + "output": "Kidney described as failure of the renal tubules of the kidney to excrete urine of sufficient acidity, resulting in metabolic acidosis." + }, + { + "input": "Concept: BSC-1 Cell Growth Inhibitor (Amino Acid, Peptide, or Protein)", + "output": "Transforming Growth Factor beta described as transforming growth factor beta-2 (414 aa, ~48 kDa) is encoded by the human TGFB2 gene. This protein plays a role in cell proliferation, cell death and a large number of signal transduction pathways." + }, + { + "input": "Concept: negative regulation of mesonephric glomerulus development (Biologic Function)", + "output": "Biologic Function described as any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric glomerulus development." + }, + { + "input": "Concept: synaptobrevin 2-SNAP-25-syntaxin-4 complex (Cell Component)", + "output": "SNARE complex described as a SNARE complex that contains synaptobrevin 2 (VAMP2), SNAP-25, and syntaxin 4 (or orthologs thereof)." + }, + { + "input": "Concept: Electrovalent Bonding (Natural Phenomenon or Process)", + "output": "chemical bond described as formation of a chemical bond following a transfer of electrons between two ions with opposite charges." + }, + { + "input": "Concept: Tuberculin purified protein derivative-containing product (ALLERGENIC EXTRACTS AND DIAGNOSTIC ANTIGENS)", + "output": "Indicator, Reagent, or Diagnostic Aid described as an extract derived from the supernatant of a culture of Mycobacterium tuberculosis grown under standardized conditions that is used in the tuberculin skin test." + }, + { + "input": "Concept: Extra-Embryonic Membrane (Extra-embryonic structure)", + "output": "Uterine membrane structure described as the membranes which surround the embryo but are not involved in formation of the embryo itself" + }, + { + "input": "Concept: Vanilla planifolia Andrews (Oils, Volatile)", + "output": "Oils, Volatile described as vanilla." + }, + { + "input": "Concept: psychomotor behavior (Individual Behavior)", + "output": "Individual Behavior described as the specific behavior of an organism that combines cognitive functions and physical movement. For example, driving a car, throwing a ball, or playing a musical instrument." + }, + { + "input": "Concept: Mitsuokella multiacidus (Mitsuokella)", + "output": "Bacterium described as any bacterial organism that can be assigned to the species Mitsuokella multacida." + }, + { + "input": "Concept: ACROCEPHALOPOLYSYNDACTYLY TYPE II (Congenital malformation syndrome)", + "output": "Polyglandular dysfunction AND/OR related disorders described as a subtype of a family of genetic disorders known as acrocephalopolysyndactyly (ACPS) disorders. It is a very rare disease; approximately 40 cases have been described in the literature. It is determined by acrocephaly, peculiar facies, brachydactyly and syndactyly in the hands, and preaxial polydactyly and syndactyly of the toes. Marked intrafamilial variability is possible. Inherited as an autosomal recessive trait." + }, + { + "input": "Concept: Triangular end part of the outermost bone of pinky finger (Anatomical Abnormality)", + "output": "Triangular epiphyses of the distal phalanges of the hand described as a triangular appearance of the epiphysis of the distal phalanx of the little finger of the hand. This epiphysis is located at the proximal end of the phalanx and is normally nearly flat." + }, + { + "input": "Concept: Body Weight Loss Less Than 10 Pounds (Intellectual Product)", + "output": "something described as a subjective response indicating that an individual has lost less than 10 pounds." + }, + { + "input": "Concept: Prevention, Early Detection of Premalignant Lesions (Early Diagnosis)", + "output": "Early Diagnosis described as a procedure that includes screening, diet and behavioral adjustments to prevent and/or detect the transformation of normal cells into cancerous lesions." + }, + { + "input": "Concept: Hyperinsulinism due to UCP2 (uncoupling protein 2) deficiency (Hereditary disorder of endocrine system)", + "output": "Digestive system hereditary disorder described as a form of diazoxide-sensitive diffuse hyperinsulinism characterised by hypoglycaemic episodes from the neonatal period, a good clinical response to diazoxide and a probable transient nature of the disease with spontaneous resolution." + }, + { + "input": "Concept: Manipulative procedure (Physiotherapy manipulation)", + "output": "Therapeutic or Preventive Procedure described as skilled dextrous action of the hands directly applied to a body part." + }, + { + "input": "Concept: Detailed new 45 minutes in-office midwifery intake (Health Care Activity)", + "output": "something described as using midwifery assessment methods in a detailed, 45-minute, in-office meeting to assess the health status of a new midwifery client to develop a midwifery treatment plan." + }, + { + "input": "Concept: Tongs, Skull (Instrument - device)", + "output": "ORTHOPEDIC DEVICES AND HARDWARE described as skull tongs for traction is an instrument used to immobilize a patient with a cervical spine injury (e.g., fracture or dislocation). The device is caliper shaped with tips that penetrate the skin. It is anchored to the skull and has a heavy weight attached to it that maintains, by traction, the patient's position." + }, + { + "input": "Concept: Sacral shear (Somatic dysfunction of sacral spine)", + "output": "something described as a complex translational motion of the sacrum in its relationship to the innominates." + }, + { + "input": "Concept: Beds, Mechanical, Birthing (Medical Device)", + "output": "something described as mechanical beds designed to permit women to assume more natural delivery positions and minimize the associated discomfort and risks during birthing. These beds typically have three sections: backrest, seat, and foot. The backrest angle, foot height, and bed height are adjustable, and the foot section can be removed to permit access to the mother's perineal area. Mechanical birthing beds lessen the lapse of time associated with transfers between beds, stretchers, and labor/delivery tables, often allowing the mother to remain in the same bed throughout labor and delivery." + }, + { + "input": "Concept: lamellipodium membrane (Cell Surface Extensions)", + "output": "something described as the portion of the plasma membrane surrounding a lamellipodium." + }, + { + "input": "Concept: Female Reproductive System Cancer TNM Finding v8 (Cancer TNM Finding by Site)", + "output": "something described as a finding about one or more characteristics of female reproductive system cancer, following the rules of the TNM AJCC v8 classification system. The TNM categories have been defined to correspond to the FIGO stages. Some amendments have been made in collaboration with FIGO, and the classifications now published have the approval of FIGO, AJCC, and all other national TNM committees of the Union for International Cancer Control (UICC)." + }, + { + "input": "Concept: Resolution of Pathologic Process (Disease Progression)", + "output": "Disease Progression described as return to the normal structure and/or function, e.g. the subsidence of a pathologic process, as the subsidence of an inflammatory lesion or new growth." + }, + { + "input": "Concept: Structure of costal margin of rib cage (Body Part, Organ, or Organ Component)", + "output": "Body Part, Organ, or Organ Component described as an arch formed by the medial margin of the cartilage of false ribs and one true rib (seventh rib to the tenth rib)." + }, + { + "input": "Concept: HUVEC Cells (Cell)", + "output": "Endothelial Cells described as endothelial cells that line venous vessels of the UMBILICAL CORD." + }, + { + "input": "Concept: Focal Facial Dermal Dysplasia, Type II (Focal facial dermal dysplasia)", + "output": "Hereditary disorder of the integument described as focal facial dermal dysplasia type II (FFDD2) is a focal facial dermal dysplasia with characteristics of congenital bitemporal scar-like depressions with additional facial dysmorphic features. Cardiac and genital or urinary abnormalities have been rarely noted. Developmental delay, severe intellectual disability, behavioral problems, and learning difficulties may be observed. Transmitted in an autosomal dominant manner with variable expressivity and incomplete penetrance." + }, + { + "input": "Concept: FLJ14303 (Antigen Gene)", + "output": "Gene or Genome described as this gene is involved in both cellular adhesion and the maintenance of mucosal surfaces." + }, + { + "input": "Concept: nonvisual photosensitivity (Physiologic Function)", + "output": "Photobiology described as abnormal responses to sunlight or artificial light due to extreme reactivity of light-absorbing molecules in tissues, especially skin." + }, + { + "input": "Concept: linoleate 8R-lipoxygenase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the reaction: O(2) + linoleate = (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate." + }, + { + "input": "Concept: 11p15.1-p14 (Cell Component)", + "output": "something described as a chromosome band present on 11p" + }, + { + "input": "Concept: regulation of cell adhesion molecule production (regulation of cellular process)", + "output": "Cell Function described as any process that modulates the rate, frequency or extent of cell adhesion molecule production. Cell adhesion molecule production is the appearance of a cell adhesion molecule as a result of its biosynthesis or a decrease in its catabolism." + }, + { + "input": "Concept: PCL-5 - Strong Negative Feelings (PCL-5 Questionnaire Question)", + "output": "Intellectual Product described as the PTSD Checklist for DSM-5 (PCL-5) In the past month, how much were you bothered by: Having strong negative feelings such as fear, horror, anger, guilt, or shame?" + }, + { + "input": "Concept: VULVAR PRURITUS (vulvar itching or burning)", + "output": "Noninflammatory disorder of the female genital organs described as itching of the vulva." + }, + { + "input": "Concept: Dehydrogenases, Acyl-CoA (Oxidoreductases Acting on CH-CH Group Donors)", + "output": "Amino Acid, Peptide, or Protein described as enzymes that catalyze the first step in the beta-oxidation of FATTY ACIDS." + }, + { + "input": "Concept: Methylenetetrahydrofolate dehydrogenase (Enzymes)", + "output": "Enzyme described as an NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher eukaryotes a trifunctional enzyme exists with additional METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE and FORMATE-TETRAHYDROFOLATE LIGASE activity. The enzyme plays an important role in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of HOMOCYSTEINE to METHIONINE via METHIONINE SYNTHETASE." + }, + { + "input": "Concept: Deficiency, Hexosaminidase Activator (Disease or Syndrome)", + "output": "Gangliosidoses, GM2 described as an autosomal recessive lysosomal storage disease caused by mutation(s) in the GM2A gene, encoding ganglioside GM2 activator. It is characterized by GM2-ganglioside accumulation in tissues resulting in hypotonia, cherry-red macular spots, and neurocognitive dysfunction." + }, + { + "input": "Concept: Family history of (contextual qualifier) (Finding with explicit context)", + "output": "Family history observations described as a record of a patient's background regarding health and disease events of blood relatives. A patient's family medical history may be important in diagnosing existing conditions." + }, + { + "input": "Concept: Mycobacterium rubropertinctum (Actinomyces)", + "output": "Bacterium described as any bacterial organism that can be assigned to the species Gordonia rubripertincta." + }, + { + "input": "Concept: histone H3 ubiquitylation (Molecular Function)", + "output": "histone ubiquitination described as the modification of histone H3 by the addition of one or more ubiquitin groups." + }, + { + "input": "Concept: benzo(j)fluoranthene (Organic Chemical)", + "output": "Hazardous or Poisonous Substance described as a yellowish, aromatic hydrocarbon consisting of five fused rings and formed by the incomplete combustion of organic matter. Benzo(j)fluoranthene is primarily found in certain foods, cigarette smoke, gasoline exhaust, coal tar, coal smoke, oil heat emissions, crude oils and used motor oils. This substance is used only for research purposes. Benzo(j)fluoranthene is reasonably anticipated to be a human carcinogen." + }, + { + "input": "Concept: Esterase, alpha-Naphthyl Acetate (Reagents)", + "output": "Esterases described as a selective cytochemical monocyte marker." + }, + { + "input": "Concept: Central cerebral sulcus (Brain part)", + "output": "Set of subarachnoid sulci described as the double-S-shaped fold or fissure on the lateral surface of each hemisphere of the cerebral cortex. The central sulcus separates the primary somatosensory cortex from the primary motor cortex and the frontal lobe from the parietal lobe." + }, + { + "input": "Concept: craves salt (Sign or Symptom)", + "output": "gastrointestinal described as an excessive desire to eat salt (sodium chloride) or salty foods. []" + }, + { + "input": "Concept: Atypical Vulvar Nevus (Neoplastic Process)", + "output": "something described as a small, well circumscribed melanocytic neoplasm that arises from the vulva and affects women in their reproductive years. It is characterized by the presence of junctional nests of melanocytes. Some of the superficial melanocytes show atypia. During pregnancy the atypical melanocytic changes may appear more prominent. This neoplasm is not associated with the presence of dysplastic nevi in other anatomic areas." + }, + { + "input": "Concept: aliphatic (S)-hydroxynitrile lyase activity (Molecular Function)", + "output": "aldehyde-lyase activity described as catalysis of the reaction: an aliphatic (S)-hydroxynitrile = an aliphatic aldehyde or ketone + cyanide." + }, + { + "input": "Concept: FAC05007 (NCCN-FACT FOSI-18 Version 2 Questionnaire Question)", + "output": "something described as national Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Ovarian Symptom Index-18 Version 2 (NCCN-FACT FOSI-18 Version 2) I have swelling in my stomach area." + }, + { + "input": "Concept: Abdomen abnormality (Anatomical Abnormality)", + "output": "Anatomical Abnormality described as a structural abnormality of the abdomen ('belly'), that is, the part of the body between the pelvis and the thorax." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, PEO (Indicator, Reagent, or Diagnostic Aid)", + "output": "something described as molecular assay reagents intended to identify mutations in the chromosome 10 open reading frame C10orf2 (formerly PEO, PEO1, PEOA3) gene, located at chromosome 10q23.3-q24.3, which encodes for a mitochondrial protein that colocalizes with mtDNA in mitochondrial nucleoids and is thought to be necessary for lifetime maintenance of mtDNA integrity. Mutations at this locus have been identified in patients with progressive external ophthalmoplegia (paralysis of the eye muscles)." + }, + { + "input": "Concept: interferon regulatory factor 3 complex (interferon regulatory factor complex)", + "output": "Cell Component described as an interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 3." + }, + { + "input": "Concept: Growth Hormone Secretagogue (peptide hormone)", + "output": "Amino Acid, Peptide, or Protein described as appetite-regulating hormone (117 aa, ~13 kDa) is encoded by the human GHRL gene. This protein is involved in satiety, thirst and anxiety and regulating growth hormone release." + }, + { + "input": "Concept: BDKRB1 (Laboratory Procedure)", + "output": "Laboratory Procedure described as a measurement of the bradykinin receptor B1 in a biological specimen." + }, + { + "input": "Concept: Open-ended (Format)", + "output": "something described as a response format that allows a respondent to answer using their own knowledge and/or feelings, without specified response categories." + }, + { + "input": "Concept: invagination involved in gastrulation with mouth forming second (Organ or Tissue Function)", + "output": "Organ or Tissue Function described as the infolding of the epithelial sheet into the embryo involved in deuterostomic gastrulation." + }, + { + "input": "Concept: Phase I/II trial (Clinical Study by Phase)", + "output": "something described as a clinical research protocol designed to study the safety, dosage levels and response to new treatment. Phase I/II trials combine a Phase I and a Phase II trial of the same treatment into a single protocol." + }, + { + "input": "Concept: METHYL VIOLET 2B (malachite green)", + "output": "Indicator, Reagent, or Diagnostic Aid described as dye and chemical solution stains for medical purposes are mixtures of synthetic or natural dyes or nondye chemicals in solutions used in staining cells and tissues for diagnostic histopathology, cytopathology, or hematology." + }, + { + "input": "Concept: Gallbladder Cancer Clinical Distant Metastasis TNM Finding v7 (Finding)", + "output": "Gallbladder Cancer Clinical TNM Finding v7 described as a clinical finding about one or more characteristics of gallbladder cancer, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases." + }, + { + "input": "Concept: response to hepatocyte growth factor stimulus (response to growth factor)", + "output": "Cell Function described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus." + }, + { + "input": "Concept: (2e)-N-(4-(3-Chloro-4-Fluoroanilino)-7-(((3s)-Oxolan-3-yl)Oxy)Quinoxazolin-6-yl)-4-(Dimethylamino)But-2-Enamide (Chemical categorised functionally)", + "output": "Organic Chemical described as a quinazoline and butenamide derivative that acts as a tyrosine kinase inhibitor of epidermal growth factor receptors (ERBB RECEPTORS) and is used in the treatment of metastatic NON-SMALL CELL LUNG CANCER." + }, + { + "input": "Concept: interleukin-16 binding (Molecular Function)", + "output": "something described as interacting selectively and non-covalently with interleukin-16." + }, + { + "input": "Concept: clostridium welchii (Bacterium)", + "output": "Clostridium species g-p described as the most common etiologic agent of GAS GANGRENE. It is differentiable into several distinct types based on the distribution of twelve different toxins." + }, + { + "input": "Concept: barytosis (POISON SPECIFIC TERMS)", + "output": "Pneumoconiosis described as a rare type of pneumoconiosis caused by long standing exposure to barium dust. It is characterized by the formation of fine dense lesions in the lung parenchyma. The lesions do not affect the lung function and disappear without treatment after the exposure to barium dust stops." + }, + { + "input": "Concept: Penile Cancer pT1b TNM Finding v8 (Penile Cancer pT1 TNM Finding v8)", + "output": "something described as penile cancer with tumor exhibiting lymphovascular invasion and/or perineural invasion or is high grade (i.e., grade 3 or sarcomatoid)." + }, + { + "input": "Concept: CDISC Clinical Classification IDS-C Test Code Terminology (Intellectual Product)", + "output": "CDISC Clinical Classification Terminology described as inventory of Depressive Symptomatology Clinician-Rated Version test code." + }, + { + "input": "Concept: Tubing, Synthetic Polymer, Tygon (Tubing, Synthetic Polymer)", + "output": "something described as synthetic polymer tubing made of a clear polyvinyl plastic substance modified with plasticizers for flexibility (Tygon). Tygon tubing is typically a small- or medium-diameter, flexible hollow cylinder designed for the transfer of fluids, either liquids or gases. Tygon tubing is usually available in standardized lengths and in a variety of diameters and wall thicknesses (i.e., gauges) that permit the use of segments of different sizes appropriate for a given application in the healthcare facility (e.g., clinical laboratory), especially when high resistance to chemicals is needed." + }, + { + "input": "Concept: Tinzaparin (Low Molecular Weight Heparin [EPC])", + "output": "Organic Chemical described as a low-molecular-weight heparin with anticoagulant properties that is used in the prevention and treatment of VENOUS THROMBOEMBOLISM, and to prevent clotting during EXTRACORPOREAL CIRCULATION." + }, + { + "input": "Concept: Benign tumour of axilla (CLINICAL CLASSIFICATION OF NEOPLASMS OF THE MUSCULOSKELETAL SYSTEM AND SOFT TISSUES)", + "output": "Benign neoplasm of thorax described as a non-metastasizing neoplasm that arises from the structures of the axilla." + }, + { + "input": "Concept: Fluid consistency type (General food and drink types)", + "output": "something described as fluids of specific viscosity for therapeutic purposes related to dysphagia (Source: Academy of Nutrition and Dietetics Nutrition Informatics Committee 2013)." + }, + { + "input": "Concept: Laboratory Certification Document (Document type)", + "output": "something described as documentation of recognition and approval by an authorized accrediting body applying known acceptable standards, that the laboratory is competent to perform required test(s), and support reliability of results." + }, + { + "input": "Concept: Arm.targetAccrualNumberRange (Target Accrual Number Range)", + "output": "Quantitative Concept described as a range of integers specifying the minimum and maximum number of subjects to be accrued for the arm." + }, + { + "input": "Concept: light-activated voltage-gated calcium channel activity (Molecular Function)", + "output": "something described as enables the transmembrane transfer of a calcium ion by a voltage-gated channel that is activated in response to light. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Mycobacterium tuberculosis, DNA, Antimicrobial-Resistant (IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Mycobacterium tuberculosis, DNA)", + "output": "Medical Device described as molecular assay reagents intended to identify Mycobacterium tuberculosis strains that have developed a highly antimicrobial resistance (e.g., to rifampin, a semisynthetic antibiotic derivative of rifamycin), by detecting specific genetic information of the deoxyribonucleic acid (DNA) of the particular strain of the target bacteria. These bacteria are the etiologic agent of antimicrobial-resistant human tuberculosis." + }, + { + "input": "Concept: FIGO Stage I Fallopian Tube Carcinoma (Fallopian Tube Cancer by AJCC v7 Stage)", + "output": "Fallopian Tube Cancer by AJCC v7 Stage described as stage I includes: (T1, N0, M0); IA (T1a, N0, M0); IB (T1b, N0, M0); IC (T1c, N0, M0). T1: Tumor limited to the fallopian tube(s). T1a: Tumor limited to one tube, without penetrating the serosal surface; no ascites. T1b: Tumor limited to both tubes, without penetrating the serosal surface; no ascites. T1c: Tumor limited to one or both tubes with extension onto or through the tubal serosa, or with malignant cells in ascites or peritoneal washings. N0: No regional lymph node metastasis. M0: No distant metastasis." + }, + { + "input": "Concept: CSS0612 (C-SSRS Children's Baseline Questionnaire Question)", + "output": "C-SSRS Children's Baseline Questionnaire Question described as columbia-Suicide Severity Rating Scale Children's Baseline - Has there been a time when you started to do something to make yourself not alive anymore (end your life or kill yourself) but someone or something stopped you before you actually did anything? What did you do?" + }, + { + "input": "Concept: Amyloid P (Laboratory Procedure)", + "output": "something described as the determination of the amount of amyloid P present in a sample." + }, + { + "input": "Concept: LYS-CYS-ASN-THR-ALA-THR-CYS-ALA-THR-GLN-ARG-LEU-ALA-ASN-PHE-LEU-VAL-HIS-SER-SER-ASN-ASN-PHE-GLY-PRO-ILE-LEU-PRO-PRO-THR-ASN-VAL-GLY-SER-ASN-THR-TYR-NH2 (Other blood glucose lowering drugs, excl. insulins in ATC)", + "output": "something described as a peptide analogue of human amylin with 3 proline substitutions at positions 25, 28 and 29, with antihyperglycemic activity. By mimicking amylin, pramlintide slows gastric emptying, inhibits digestive secretions (gastric acid, pancreatic enzymes, and bile), reduces glucagon secretion, and increases satiety; all of these actions are mediated mostly by glucose-sensitive areas in the brain stem. The overall result is a decrease in blood glucose levels. The use of pramlintide may cause an increased risk of insulin-induced hypoglycemia." + }, + { + "input": "Concept: malonyl-CoA metabolism (acyl-CoA metabolic process)", + "output": "Molecular Function described as the chemical reactions and pathways involving malonyl-CoA, the S-malonyl derivative of coenzyme A." + }, + { + "input": "Concept: Luffa operculata / ball luffa (Homeopathic remedies letter L)", + "output": "something described as ball luffa." + }, + { + "input": "Concept: DEVICE, SKIN POTENTIAL MEASUREMENT (Medical Device)", + "output": "Medical Device described as a skin potential measurement device is a general diagnostic device used to measure skin voltage by means of surface skin electrodes." + }, + { + "input": "Concept: IGG (FD FRAGMENT SPECIFIC), ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)", + "output": "Indicator, Reagent, or Diagnostic Aid described as an immunoglobulin G (Fd fragment specific) immunological test system is a device that consists of the reagents used to measure by immunochemical techniques the amino terminal (antigen-binding) end (Fd fragment) of the heavy chain (a subunit) of the immunoglobulin antibody molecule in serum. Measurement of immunoglobulin G Fd fragments aids in the diagnosis of plasma antibody-forming cell abnormalities." + }, + { + "input": "Concept: EDN2 wt Allele (EDN2 gene)", + "output": "EDN2 gene described as human EDN2 wild-type allele is located in the vicinity of 1p34 and is approximately 6 kb in length. This allele, which encodes endothelin-1 protein, plays a role in the mediation of smooth muscle cell contraction." + }, + { + "input": "Concept: core 1 beta3-Gal-T (Glycosyltransferase Gene)", + "output": "Glycosyltransferase Gene described as this gene is involved in generation of the common core 1 O-glycan structure." + }, + { + "input": "Concept: Microsurgery Vascular Clips (Medical Device)", + "output": "something described as vascular surgical clips designed for the atraumatic compression of veins or arteries during microsurgical procedures, usually to cause total or partial temporary occlusion. These clips are typically small cross-action snap-on instruments. Microsurgical vascular clips are typically used in vascular procedures such as testicular implantation; they are also used in the restoration of the vas deferens after vasectomy (i.e., vasovasostomy)." + }, + { + "input": "Concept: 2-dehydro-3-deoxy-D-gluconic acid catabolic process (aldonic acid catabolic process)", + "output": "aldonic acid catabolic process described as the chemical reactions and pathways resulting in the breakdown of 2-dehydro-3-deoxy-D-gluconic acid." + }, + { + "input": "Concept: yg (Quantitative Concept)", + "output": "something described as the metric unit of mass equal to one a septillionth of a gram (10E-24 gram)." + }, + { + "input": "Concept: Small epiphyses of the thumb (Small epiphyses of the phalanges of the hand)", + "output": "Small epiphyses of the phalanges of the hand described as abnormally small size of one or more of the epiphyses of the thumb with respect to age-dependent norms." + }, + { + "input": "Concept: FAC06215 (FACT-BRM Version 4 Questionnaire Question)", + "output": "FACT-BRM Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Biologic Response Modifiers Version 4 - Emotional Well-Being: I feel sad." + }, + { + "input": "Concept: MERCURY (Transition Elements)", + "output": "Metals, Heavy described as a silver-white, poisonous metal that is a liquid at ordinary temperatures. It is commonly used in thermometers and amalgams, and has been used as an ingredient in some homeopathic medicines and in very small amounts as a preservative in viral vaccines." + }, + { + "input": "Concept: ANTIGEN, CF (INCLUDING CF CONTROL), EPSTEIN-BARR VIRUS (Immunologic Factor)", + "output": "something described as epstein-Barr virus serological reagents are devices that consist of antigens and antisera used in serological tests to identify antibodies to Epstein-Barr virus in serum. The identification aids in the diagnosis of Epstein-Barr virus infections and provides epidemiological information on diseases caused by these viruses. Epstein-Barr viruses are thought to cause infectious mononucleosis and have been associated with Burkitt's lymphoma (a tumor of the jaw in African children and young adults) and postnasal carcinoma (cancer)." + }, + { + "input": "Concept: 5-(3-dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,d)cycloheptene (Organic Chemical)", + "output": "Organic Chemicals described as tricyclic antidepressant with anticholinergic and sedative properties; it appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters; it also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines." + }, + { + "input": "Concept: LIGHT (Temporal Concept)", + "output": "Personal Attribute described as the amount of ambient light/darkness to which a subject is exposed in a period of time." + }, + { + "input": "Concept: Tribulus Adams & Adams, 1853 (Plant)", + "output": "Muricidae described as a plant genus of the family ZYGOPHYLLACEAE. Members contain steroidal saponins. Ingestion by grazing animals causes PHOTOSENSITIVITY DISORDERS called geeldikkop (yellow thick head) in South Africa." + }, + { + "input": "Concept: area 34 of Brodmann (Brodmann area)", + "output": "something described as a subdivision of the cytoarchitecturally defined hippocampal region of the human cerebral cortex. It is located in the entorhinal area on the medial aspect of the temporal lobe. It and the area 28 of Brodmann (guenon) together constitute approximately the entorhinal area ( Brodmann-1909 )." + }, + { + "input": "Concept: atorvastatin (A [Preparations])", + "output": "Dyslipidemics, HMG CoA Reductase Inhibitors described as the calcium salt of atorvastatin, a synthetic lipid-lowering agent. Atorvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent increases the number of LDL receptors on hepatic cell surfaces, enhancing the uptake and catabolism of LDL and reducing LDL production and the number of LDL particles, and lowers plasma cholesterol and lipoprotein levels. Like other statins, atorvastatin may also display direct antineoplastic activity, possibly by inhibiting farnesylation and geranylgeranylation of proteins such as small GTP-binding proteins, which may result in the arrest of cells in the G1 phase of the cell cycle. This agent may also sensitize tumor cells to cyctostatic drugs, possibly through the mTOR-dependent inhibition of Akt phosphorylation. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28837\" active clinical trials using this agent." + }, + { + "input": "Concept: graylag goose (Bird)", + "output": "Geese described as greylag goose species." + }, + { + "input": "Concept: KTN1 wt Allele (KTN1 gene)", + "output": "Gene or Genome described as human KTN1 wild-type allele is located in the vicinity of 14q22.1 and is approximately 104 kb in length. This allele, which encodes kinectin protein, is involved in the regulation of kinesin-dependent transport." + }, + { + "input": "Concept: CSS04-Suicidal Behavior-P Y (Intellectual Product)", + "output": "something described as columbia-Suicidality Severity Rating Scale Baseline/Screening Version (C-SSRS Baseline/Screening Version) Suicidal behavior was present during the assessment period? (Past X Years)." + }, + { + "input": "Concept: Every day smoker (Current Smoker)", + "output": "Tobacco smoking consumption - finding described as indicates a person who has smoked at least 100 cigarettes in his or her lifetime and who currently smokes every day." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, DCX (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)", + "output": "something described as molecular assay reagents intended to identify mutations in the doublecortin (DCX) gene, located at chromosome Xq22.3-q23, which encodes the neuronal migration protein doublecortin. Genetic variants at this locus have been associated with lissencephaly." + }, + { + "input": "Concept: Unresectable Small Intestinal Cancer (Small intestine carcinoma)", + "output": "Unresectable Digestive System Carcinoma described as carcinoma of the small intestine not amendable to resection." + }, + { + "input": "Concept: Tetrasomy, short arm of chromosome 9 (Partial tetrasomy 9 syndrome)", + "output": "Partial tetrasomy 9 syndrome described as partial tetrasomy involving the short arm of chromosome 9 with psychomotor retardation and variable multiple craniofacial, skeletal, cardiovascular, and urogenital abnormalities." + }, + { + "input": "Concept: infantile; pyloric obstruction (Congenital constriction of pylorus)", + "output": "Gastrointestinal obstruction described as narrowing of the pyloric channel, the opening from the stomach to the duodenum, caused by enlargement and thickening of the circular muscular layer surrounding this opening." + }, + { + "input": "Concept: Northern Mariana Islands (Country)", + "output": "Micronesia described as a country in the Pacific, comprising islands in the North Pacific Ocean, about three-quarters of the way from Hawaii to the Philippines, north of Guam." + }, + { + "input": "Concept: Discus intercalatus (Cell Component)", + "output": "something described as a complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells." + }, + { + "input": "Concept: Segmenta lumbalia (Spinal Cord)", + "output": "something described as the parts of the spinal cord that give rise to nerves entering and leaving the spinal canal at the levels of the lumbar vertebrae. These segments have massive anterior gray column and posterior gray column and are nearly circular in horizontal sections ( Carpenter-1983 ). Defined by dissection, they are found in all vertebrates ( Swanson-2015 )." + }, + { + "input": "Concept: Electrocardiography Cardiac Transcutaneous Electrodes (Medical Device)", + "output": "Medical Device described as electrocardiography (ECG) electrodes designed to transmit the electrical signals associated with the cardiac activity from skin contact (e.g., thoracic skin) to an electrocardiograph or cardiac monitor; the electrodes are usually applied externally to the chest wall. These electrodes are metal devices usually attached to a tape, foam, or cloth substrate; they are available in a variety of configurations and they are typically applied with a conductive wet gel to provide instant electrical contact. Reusable as well as disposable transcutaneous electrocardiography electrodes are available; they are frequently supplied in a set of twelve electrodes. Transcutaneous electrocardiography cardiac electrodes are mainly intended to obtain a graphic of the bioelectrical signals from the heart (i.e., an electrocardiogram); they are used in diagnostic, therapeutic, and surgical procedures." + }, + { + "input": "Concept: Esophageal Verrucous Cancer (Neoplastic Process)", + "output": "Neoplastic Process described as a rare variant of esophageal squamous cell carcinoma. It is an exophytic, cauliflower-like or papillary mass that can arise in any part of the esophagus. This variant of squamous cell carcinoma grows slowly and invades locally, with a very low metastasizing potential." + }, + { + "input": "Concept: Diffuse cerebral and cerebellar atrophy, intractable seizures, progressive microcephaly syndrome (Cerebral atrophy)", + "output": "Multiple system malformation syndrome described as a rare genetic central nervous system malformation syndrome with characteristics of congenital progressive microcephaly, neonatal to infancy-onset of severe intractable seizures and diffuse cerebral cortex and cerebellar vermis atrophy with mild cerebellar hemisphere atrophy associated with profound global developmental delay. Hypotonia or hypertonia with brisk reflexes, variable dysmorphic facial features, ophthalmological signs (cortical visual impairment, nystagmus, eye deviation) and episodes of sudden extreme agitation caused by severe illness may also be associated. Caused by compound heterozygous mutation in the QARS gene on chromosome 3p21." + }, + { + "input": "Concept: alpha-actinin-1, human (Biologically Active Substance)", + "output": "Biologically Active Substance described as alpha-actinin-1 (892 aa, ~103 kDa) is encoded by the human ACTN1 gene. This protein plays a role in F-actin crosslinking." + }, + { + "input": "Concept: MOS (Intellectual Product)", + "output": "something described as a survey of multiple dimensions of support, representing the physical functioning scale." + }, + { + "input": "Concept: Cholinergic Differentiation Factor (cytokine)", + "output": "Amino Acid, Peptide, or Protein described as affects many systems, including hematopoietic, embryonic, bone, hepatic, neuronal, and fat tissues." + }, + { + "input": "Concept: Crabs, Blue (Callinectes)", + "output": "Eukaryote described as species in the genus Callinectes, family Portunidae, order DECAPODA, found in the Chesapeake Bay." + }, + { + "input": "Concept: THORACOPLASTY (Chest wall procedure)", + "output": "Chest wall and mediastinal therapeutic procedures described as surgical removal of a rib to gain access during surgery or to collapse the chest wall and a diseased lung." + }, + { + "input": "Concept: Trial Summary Domain (Domain)", + "output": "Domain described as a trial design domain that contains one record for each trial summary characteristic. This domain is not subject oriented." + }, + { + "input": "Concept: immunohemolytic anemia (Autoimmune Diseases)", + "output": "Autoimmune hemolytic anemia described as acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS." + }, + { + "input": "Concept: mitomycin-c (Antibiotics, Antineoplastic)", + "output": "Antineoplastic Agents described as antineoplastic antibiotic produced by Streptomyces caespitosus that acts as an alkylating agent causing cross-linking of DNA and inhibition of DNA synthesis." + }, + { + "input": "Concept: regulation of cellular response to stress (Cell Function)", + "output": "regulation of cellular process described as any process that modulates the frequency, rate or extent of a cellular response to stress. Cellular response to stress is a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." + }, + { + "input": "Concept: Tumor of Lung (Respiratory Tract Neoplasms)", + "output": "something described as a benign or malignant, primary or metastatic neoplasm involving the lungs. Representative examples of benign neoplasms include adenoma, papilloma, chondroma, and endobronchial lipoma. Representative examples of malignant neoplasms include carcinoma, carcinoid tumor, sarcoma, and lymphoma." + }, + { + "input": "Concept: carvedilol phosphate extended-release capsule (Adrenergic Antagonists)", + "output": "Clinical Drug described as an extended-release capsule formulation containing the phosphate salt of carvedilol, a nonselective beta-adrenergic blocking agent with alpha 1-adrenergic blocking activity. Carvedilol is a racemic mixture; the S(-) enantiomer non-selectively binds to and blocks beta-adrenergic receptors, exerting negative inotropic and chronotropic effects, leading to a reduction in cardiac output. Both R(+) and S(-) enantiomers bind to and block alpha 1-adrenergic receptors with equal potency, causing vasodilation and a reduction in peripheral vascular resistance. This agent has no intrinsic sympathomimetic activity." + }, + { + "input": "Concept: Antimicrobial - Induced Nephropathy (Drug-induced Nephropathy)", + "output": "Drug-induced Nephropathy described as kidney damage resulting from exposure to antimicrobials." + }, + { + "input": "Concept: Eye Neoplasm (NCI CTEP Simplified Disease Classification Terminology)", + "output": "Intellectual Product described as eye Neoplasm is an NCI Cancer Therapeutic Evaluation Program (CTEP) Simplified Disease Classification (SDC) category used to organize cancer-related disease coding that harmonizes with and supports reporting based on the global standard Medical Dictionary for Drug Regulatory Reporting (MedDRA) terminology." + }, + { + "input": "Concept: NPI1-Delusions FxS Score (NPI Questionnaire Question)", + "output": "something described as neuropsychiatric Inventory (NPI) Delusions: (frequency score x severity score)." + }, + { + "input": "Concept: HOSP MATERIALS MANAGEMENT (Health Care Activity)", + "output": "Hospital Administration described as the management of all procurement, distribution, and storage of equipment and supplies, as well as logistics management including laundry, processing of reusables, etc." + }, + { + "input": "Concept: CLOSTRIDIUM COCLEATUM (Bacterium)", + "output": "Clostridium species a-f described as any bacterial organism that can be assigned to the species Clostridium cocleatum." + }, + { + "input": "Concept: eltrombopag olamine (Amino Acid, Peptide, or Protein)", + "output": "Agent Affecting Blood or Body Fluid described as the orally active ethanolamine salt of eltrombopag, a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. Eltrombopag binds to and stimulates the transmembrane domain of the platelet thrombopoietin receptor (TPO-R or CD110), a member of the hematopoietin receptor superfamily. Activation of TPO-R leads to the proliferation and differentiation of cells in the megakaryocytic lineage and an increase in platelet production." + }, + { + "input": "Concept: Visual Prompts will not Clear (Medical Device Operates Differently Than Expected)", + "output": "Finding described as problem with visual messages which continue to be displayed on/by the device after the appropriate action has been taken." + }, + { + "input": "Concept: Sporotrichum schenkii (Sporothrix)", + "output": "Mitosporic Fungi described as a species of thermally dimorphic fungi in the phylum Ascomycota. In the environment S. schenckii is found growing as filamentous hyphae; in host tissue it is found as a yeast. This species is the causative agent of sporotrichosis." + }, + { + "input": "Concept: Fourth Ventricle and Brain Stem Ependymal Tumor (Neoplastic Process)", + "output": "Ventricular and Brain Stem Ependymal Tumor described as an ependymal tumor affecting the fourth ventricle and the brain stem." + }, + { + "input": "Concept: LDH1LDH (Protein or Enzyme Type Measurement)", + "output": "something described as the determination of the ratio of LDH isoenzyme 1 compared to total LDH present in a sample. The measurement may be expressed as a ratio or percentage." + }, + { + "input": "Concept: Parasternal short axis view at the mitral valve level (Parasternal short axis view)", + "output": "something described as imaging plane with the transducer at the left sternal border oriented along the short axis of the left ventricle, which includes the left ventricle at the level of the mitral valve leaflets, ventricular septum, and right ventricle. This plane is inferior to the aortic valve at the base of the heart." + }, + { + "input": "Concept: Protuberant (Abdomen distended)", + "output": "something described as an indication that there is unusual or prominent convexity of the abdomen on visual inspection." + }, + { + "input": "Concept: autologous iC9-CAR19 T cells (Cell)", + "output": "Antineoplastic Immune Cell described as a preparation of autologous T-lymphocytes that are transduced with a retroviral vector encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19 and the inducible suicide gene human caspase 9 (iCASP9 or iC9), that is linked to a drug binding domain, with potential immunomodulating and antineoplastic activities. The iCASP9 construct consists of the entire coding sequence for the human FK506-drug binding protein (FKBP12) with an F36V mutation (FKBP12-F36V) that is linked to the gene encoding iC9, which is a modified form of the CASP9 gene where the sequences encoding the endogenous caspase activation and recruitment domains have been deleted. Upon intravenous administration, autologous iCASP9-CD19-expressing T-lymphocytes (iC9-CAR19 T-cells) target and bind to CD19-expressing tumor cells, thereby selectively lysing these tumor cells. If the administered T-cells cause unacceptable side effects, the chemical homodimerizer AP1903, which binds to the FKBP12-F36V drug-binding domain, can be administered; this induces caspase 9 expression, and results in apoptosis of the administered iC9-CAR19 T-cells. The CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies." + }, + { + "input": "Concept: Mild Hypothermia, Induced (Therapeutic or Preventive Procedure)", + "output": "something described as body temperature of a patient is induced to 91-95 degree F or 33-35 C." + }, + { + "input": "Concept: Product containing Denileukin Diftitox (Recombinant interleukin 2 moiety)", + "output": "Recombinant interleukin 2 moiety described as a cytotoxic recombinant protein consisting of interleukin-2 (IL-2) protein sequences fused to diphtheria toxin. The IL-2 protein sequence moiety of denileukin difitox directs the cytocidal action of diphtheria toxin to cells that express IL-2 receptors. After the toxin moiety is internalized into target IL-2 receptor-expressing cells, its catalytic domain catalyzes the transfer of the ADP-ribose moiety of NAD to a posttranslationally modified histidine residue of elongation factor 2 (EF-2), called diphthamine. This covalent modification inactivates EF-2 and disrupts polypeptide chain elongation, resulting in cell death. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1476\" active clinical trials using this agent." + }, + { + "input": "Concept: SAK, MOUSE, HOMOLOG OF (Gene or Genome)", + "output": "Serine/Threonine Protein Kinase Gene described as this gene plays a role in the formation of centrioles or basal bodies." + }, + { + "input": "Concept: Archaeal DNA (Nucleic Acid, Nucleoside, or Nucleotide)", + "output": "Nucleic Acid, Nucleoside, or Nucleotide described as deoxyribonucleic acid that makes up the genetic material of archaea." + }, + { + "input": "Concept: positive regulation of cholesterol esterification (Molecular Function)", + "output": "positive regulation of cellular metabolic process described as any process that increases the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle." + }, + { + "input": "Concept: Workstations, Pharmacy, Medication Dispensing (Medical Device)", + "output": "something described as pharmacy workstations designed to obtain and process data related to prescription verification, tracking, management and/or manual dispensing of medications. These workstations typically consist of a computerized unit including a display, data input devices (e.g., keyboards, touchscreens), and barcode scanners and labelers; the workstation usually includes dedicated software that permits communication with clinical pharmacy data management systems. Medication dispensing workstations are intended to manage, check and verify the status of the complete dispensing process in real time; when placed at the point of dispensing the workstation facilitates proper identification and tracking of both patients and medications." + }, + { + "input": "Concept: Central Tano Language (Language)", + "output": "something described as languages of the Niger-Congo family spoken in Ghana and Ivory Coast by the Akan people." + }, + { + "input": "Concept: Catharsis (Emotional Adjustment)", + "output": "Mental Process described as process of reliving painful experiences and feelings, and the associated emotional responses." + }, + { + "input": "Concept: Streptococcus sanguinis (Streptococcus)", + "output": "something described as gram positive organism found in dental plaque, in blood, on heart valves in subacute endocarditis, and infrequently in saliva and throat specimens;. L-forms are associated with recurrent aphthous stomatitis." + }, + { + "input": "Concept: p53/MDM2 Interaction Inhibitor (Organic Chemical)", + "output": "Pharmacologic Substance described as any agent that binds to mouse double minute 2 (human double minute 2 homolog; MDM2; HDM2) and prevents the interaction with the tumor suppressor protein p53, with potential antineoplastic activity." + }, + { + "input": "Concept: Stage 0 Intrahepatic Bile Duct Carcinoma AJCC v8 (Neoplastic Process)", + "output": "Intrahepatic Bile Duct Cancer by AJCC v8 Stage described as stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ (intraductal tumor). N0: No regional lymph node metastasis. M0: No distant metastasis." + }, + { + "input": "Concept: Ultrasonics (Sound - physical agent)", + "output": "Physical Phenomenon or Property described as high frequency sound, generally with a frequency greater than 20,000 Hz." + }, + { + "input": "Concept: Rivermead Post-Concussion Symptoms Questionnaire (Clinical or Research Assessment Questionnaire)", + "output": "something described as a standardized rating scale originally developed by King et al in 1995, which is used to measure the severity of symptoms following a mild or moderate traumatic brain injury (TBI). The questionnaire requires a subject to rate the severity of 16 different cognitive, somatic, and emotional symptoms after a TBI on a scale of 0 to 4: not experienced at all (0), no more of a problem (1), a mild problem (2), a moderate problem (3), or a severe problem (4)." + }, + { + "input": "Concept: Platelet-Activating Factor Acetylhydrolase 1b, Catalytic Subunit 2 (30kDa) wt Allele (Gene or Genome)", + "output": "Gene or Genome described as human PAFAH1B2 wild-type allele is located in the vicinity of 11q23 and is approximately 33 kb in length. This allele, which encodes platelet-activating factor acetylhydrolase IB subunit beta protein, plays a role in the metabolism of platelet-activating factor." + }, + { + "input": "Concept: negative regulation by blue light of anion channel activity (Physiologic Function)", + "output": "negative regulation of anion channel activity described as any process in which blue light stops, prevents, or reduces the frequency, rate, or extent of the anion channel activity." + }, + { + "input": "Concept: Reverse Triiodothyronine Measurement (Laboratory Procedure)", + "output": "something described as a measurement of the reverse triiodothyronine in a biological specimen." + }, + { + "input": "Concept: Stage I Grade I Follicular Small Cleaved Cell Lymphoma (Stage I Indolent Adult Non-Hodgkin Lymphoma)", + "output": "Neoplastic Process described as ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE)." + }, + { + "input": "Concept: Wet Cough (cough quality)", + "output": "Coughing described as a cough accompanied by expectorated secretions." + }, + { + "input": "Concept: H-lignin biosynthetic process (lignin biosynthetic process)", + "output": "p-hydroxyphenyl lignin metabolic process described as the chemical reactions and pathways resulting in the formation of p-hydroxyphenyl lignin." + }, + { + "input": "Concept: deubiquitination (Post-Translational Protein Processing)", + "output": "Molecular Function described as the removal of one or more ubiquitin groups from a protein." + }, + { + "input": "Concept: upregulation of protein localisation to nucleolus (positive regulation of protein localization to nucleus)", + "output": "Cell Function described as any process that activates or increases the frequency, rate or extent of protein localization to nucleolus." + }, + { + "input": "Concept: Syncope, CTCAE 5 (Finding)", + "output": "Nervous System Disorders, CTCAE described as a disorder characterized by spontaneous loss of consciousness caused by insufficient blood supply to the brain." + }, + { + "input": "Concept: Protein-Tyrosine Kinases, src (Protein Tyrosine Kinase)", + "output": "Amino Acid, Peptide, or Protein described as a PROTEIN-TYROSINE KINASE family that was originally identified by homology to the Rous sarcoma virus ONCOGENE PROTEIN PP60(V-SRC). They interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways. Oncogenic forms of src-family kinases can occur through altered regulation or expression of the endogenous protein and by virally encoded src (v-src) genes." + }, + { + "input": "Concept: NPI1A03 (NPI Questionnaire Question)", + "output": "NPI Questionnaire Question described as neuropsychiatric Inventory - Does the patient believe that his/her spouse is having an affair?" + }, + { + "input": "Concept: Sample Sizes (Epidemiologic Research Design)", + "output": "Statistical Sample Parameters described as a subset of a larger population, selected for investigation to draw conclusions or make estimates about the larger population." + }, + { + "input": "Concept: protein-containing complex assembly involved in synapse maturation (Cell Function)", + "output": "something described as the aggregation, arrangement and bonding together of a set of components to form a protein complex that contributes to synapse maturation." + }, + { + "input": "Concept: TAK-788 (Antineoplastic Enzyme Inhibitor)", + "output": "Organic Chemical described as an orally available inhibitor of specific mutant forms of both human epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2; ERBB2), with potential antineoplastic activity. Upon oral administration, EGFR/HER2 inhibitor TAK-788 specifically and irreversibly binds to and inhibits certain mutant forms of EGFR and HER2. This prevents EGFR- and HER2-mediated signaling and leads to cell death in EGFR mutant- and HER2 mutant-expressing tumor cells. EGFR and HER2, receptor tyrosine kinases mutated in many tumor cell types, play key roles in tumor cell proliferation and tumor vascularization." + }, + { + "input": "Concept: GAIA Level 3 Low Birth Weight (GAIA Low Birth Weight Level of Diagnostic Certainty)", + "output": "GAIA Low Birth Weight Level of Diagnostic Certainty described as level 3 Low Birth Weight is defined by three criteria: first, a newborn infant must be weighed within the first 48 hours of life; second, weight is measured using a dial/ spring/ color-coded scale; third, weight is assessed as less than 2500 grams." + }, + { + "input": "Concept: ventral tegmental gray (Tissue)", + "output": "something described as a composite structure of the midbrain tegmentum that includes the ventral tegmental area, the interpeduncular nucleus and the peripeduncular nucleus ( Crosby-1962 )." + }, + { + "input": "Concept: Attometer (Quantitative Concept)", + "output": "something described as a metric unit of length equal to one quintillionth of a meter (10E-18 meter)." + }, + { + "input": "Concept: Social Cohesion (Social Behavior)", + "output": "something described as mutual bonds formed among the members of a group as a consequence of their combined efforts toward a common goal or purpose." + }, + { + "input": "Concept: TSI (Penutian language)", + "output": "something described as a dialect of the Tsimshian language spoken in northwestern British Columbia and southeastern Alaska." + }, + { + "input": "Concept: Oral-facial-digital syndrome Gabrielli type (Congenital hearing disorder)", + "output": "Intellectual Disability described as an extremely rare, sporadic form of Orofaciodigital syndrome with only a few reported cases and characteristics of facial (blepharophimosis, bulbous nasal tip, broad nasal bridge, downslanting palpebral fissures and low set ears) and skeletal (post-axial polydactyly and fusion of vertebrae) malformations along with severe intellectual disability, deafness and congenital heart defects." + }, + { + "input": "Concept: hRev (Nuclear Receptor Gene)", + "output": "something described as this gene plays a role in both transcriptional regulation and circadian rhythms." + }, + { + "input": "Concept: bromodomain and extra-terminal protein inhibitor RO6870810 (BET Inhibitor)", + "output": "Organic Chemical described as a small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins with potential antineoplastic activity. Upon administration, the BET inhibitor RO6870810 binds to the acetylated lysine recognition motifs found in the bromodomain of BET proteins, which prevents the interaction between BET proteins and acetylated histones. This interaction disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of tumor cell growth. Characterized by a tandem repeat of bromodomains at the N-terminus, BET proteins, comprised of BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that play an important role during cellular development and growth." + }, + { + "input": "Concept: Interferon Regulatory Factor 9 (TRANSCRIPTION FACTOR)", + "output": "Biologically Active Substance described as interferon regulatory factor 9 (393 aa, ~44 kDa) is encoded by the human IRF9 gene. This protein plays a role in activating transcription via type I interferon signaling." + }, + { + "input": "Concept: nucleobase transmembrane transporter activity (transmembrane transporter activity)", + "output": "Molecular Function described as enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other." + }, + { + "input": "Concept: Sake - alcoholic beverage (Alcoholic Beverages)", + "output": "something described as a Japanese alcoholic beverage made from fermented rice; usually served hot." + }, + { + "input": "Concept: Component of Study Protocol (Intellectual Product)", + "output": "something described as a component of a plan on which a study is based." + }, + { + "input": "Concept: Snares, Ear (Medical Device)", + "output": "something described as an ear, nose, and throat manual surgical instrument is one of a variety of devices intended for use in surgical procedures to examine or treat the bronchus, esophagus, trachea, larynx, pharynx, nasal and paranasal sinus, or ear. This generic type of device includes the esophageal dilator; tracheal bistour (a long, narrow surgical knife); tracheal dilator; tracheal hook; laryngeal injection set; laryngeal knife; laryngeal saw; laryngeal trocar; laryngectomy tube; adenoid curette; adenotome; metal tongue depressor; mouth gag; oral screw; salpingeal curette; tonsillectome; tonsil guillotine; tonsil screw; tonsil snare; tonsil suction tub; tonsil suturing hook; antom reforator; ethmoid curette; frontal sinus-rasp; nasal curette; nasal rasp; nasal rongeur; nasal saw; nasal scissors; nasal snare; sinus irrigator; sinus trephine; ear curette; ear excavator; ear rasp; ear scissor, ear snare; ear spoon; ear suction tub; malleous ripper; mastoid gauge; microsurgical ear chisel; myringotomy tube inserter; ossici holding clamp; sacculotomy tack inserter; vein press; wire ear loop; microrule; mirror; mobilizer; ear, nose, and throat punch; ear, nose and throat knife; and ear, nose, and throat trocar." + }, + { + "input": "Concept: Grade 2 Arachnoiditis (Arachnoiditis, CTCAE)", + "output": "Finding described as moderate symptoms; limiting instrumental ADL" + }, + { + "input": "Concept: Temporomandibul joint crepitus (Joint crepitus)", + "output": "something described as noises from the temporomandibular joint during mandibular movement (e.g., chewing). Temporomandibular joint crepitus is often described as a clicking, popping, grating sound." + }, + { + "input": "Concept: COMPRESSION (Natural Phenomenon or Process)", + "output": "Action described as a pressing or squeezing together. In medicine, it can describe a structure, such as a tumor, that presses on another part of the body, such as a nerve. It can also describe the flattening of soft tissue, such as the breast, that occurs during a mammogram (x-ray of the breast)." + }, + { + "input": "Concept: Physalis (Physaleae)", + "output": "Physaleae described as a plant genus of the family SOLANACEAE. Members contain physalin and withangulatin." + }, + { + "input": "Concept: Grade 5 Infantile Vomiting, Adverse Event (Infantile Vomiting, Adverse Event)", + "output": "Finding described as death." + }, + { + "input": "Concept: QD (Frequencies)", + "output": "Intervals of days described as occurring or done each day." + }, + { + "input": "Concept: treacher collin syndrome (Disorder of head)", + "output": "Congenital anomaly of head described as a congenital disorder of craniofacial development with characteristics of bilateral symmetrical oto-mandibular dysplasia without abnormalities of the extremities, and associated with several head and neck defects. The syndrome is caused by mutations in the TCOF1 gene (5q32) encoding the nucleolar phosphoprotein Treacle or in the POLR1C (6p21.1) or POLR1D (13q12.2) genes, coding for RNA polymerase I and III subunits. Transmission is autosomal dominant with 90% penetrance and variable expressivity, even among affected patients within the same family. Mutations in POLR1C gene are inherited in autosomal recessive manner." + }, + { + "input": "Concept: Pachygyria with 5-10 mm cortical thickness (Pachygyria)", + "output": "Congenital Abnormality described as pachygyria with a mildly thickend cerebral cortex measuring 5-10 mm. Note that cortical thickness cannot be measured reliably on scans done between 3 and 24 months of age." + }, + { + "input": "Concept: pregnane X receptor, human (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as nuclear receptor subfamily 1 group I member 2 (434 aa, ~50 kDa) is encoded by the human NR1I2 gene. This protein is involved in the metabolism of xenobiotics and steroids." + }, + { + "input": "Concept: Axillary Dissection (Lymph node excision)", + "output": "Therapeutic or Preventive Procedure described as surgical removal of the lymph nodes located in the cavity beneath the junction of the arm and the thorax, or axilla (armpit). This procedure is commonly performed as a component of cancer staging." + }, + { + "input": "Concept: Rheumatism (Disease or Syndrome)", + "output": "Connective Tissue Diseases described as inflammatory and degenerative diseases of connective tissue structures, such as arthritis." + }, + { + "input": "Concept: FAC015-I Feel Nervous (Intellectual Product)", + "output": "FACT-HEP Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Hepatobiliary Version 4 - Emotional Well-Being: I feel nervous." + }, + { + "input": "Concept: CARD8 Gene (Gene or Genome)", + "output": "Apoptosis Regulation Gene described as this gene is involved in the regulation of apoptosis." + }, + { + "input": "Concept: CCA-adding enzyme activity (Genetic Function)", + "output": "Genetic Function described as post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3' end of the tRNA, yielding a diphosphate with each nucleotide addition." + }, + { + "input": "Concept: Losoxantrone HCl (Nucleic Acid, Nucleoside, or Nucleotide)", + "output": "Pharmacologic Substance described as the hydrochloride salt form of losoxantrone, an anthrapyrazole-based antineoplastic antibiotic. Losoxantrone intercalates into DNA, induces single- and double-stranded DNA breaks and inhibits topoisomerase II, thereby inhibiting DNA replication and repair as well as RNA and protein synthesis. Losoxantrone is less cardiotoxic than doxorubicin." + }, + { + "input": "Concept: Bed nuclei of the stria terminalis posterior division principal nucleus (Body Part, Organ, or Organ Component)", + "output": "something described as a component of the nuclei of stria terminalis defined on the basis of topology, connectivity and multiple stains in the rat. It is one of seven components of the posterior nuclei of stria terminalis in the Functional CNS Model - Rat ( Swanson-2004 )." + }, + { + "input": "Concept: RPTESTCD (Intellectual Product)", + "output": "Intellectual Product described as terminology associated with the reproductive system findings test code codelist of the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: Nerve Growth Factor 1 (neurotrophic factor)", + "output": "Amino Acid, Peptide, or Protein described as a protein made by the body that causes certain nerve cells to grow and helps keep them alive." + }, + { + "input": "Concept: HYOU1 gene (Gene or Genome)", + "output": "Gene or Genome described as this gene plays in the regulation of cellular response to ischemic stress conditions." + }, + { + "input": "Concept: CYP2C9*18 (CYP2C9 gene)", + "output": "CYP2C9 gene described as human CYP2C9*18 allele is located within 10q24 and is approximately 33 kb in length. This allele, a variant form of the CYP2C9 wild-type allele, encodes cytochrome P450 2C9*18 protein. The CYP2C9*18 allele exhibits a clinically-relevant SNP (c.1190A>C) in exon 8 that results in a D397A coding change. This alteration in protein sequence decreases the in vivo enzymatic activity of the cytochrome P450 2C9*18 protein." + }, + { + "input": "Concept: Supraauricular sinus (Congenital Abnormality)", + "output": "Ear structure described as benign congenital lesion of the supraauricular soft tissue consisting of a blind-ending narrow tube or pit." + }, + { + "input": "Concept: Retire (Activity)", + "output": "Action described as to cease active participation in; remove from active use." + }, + { + "input": "Concept: TSLOC (Geographic Area)", + "output": "Geographic Area described as the geographic location in which a test is managed." + }, + { + "input": "Concept: Corpus mamillare (Hypothalamic structure)", + "output": "Gray matter of hypothalamus described as a small, paired, spherical protuberance lying between the cerebral peduncles on the posterior portion of the hypothalamus, which functionally belongs to the medial limbic circuit." + }, + { + "input": "Concept: Tables, Instrument (Table - furniture)", + "output": "Medical Device described as tables including an appropriate (e.g., stainless steel) top surface with no crevices, screws, or rivets. Most tables include telescoping pedestals for height adjustment and swivel caster bases. These tables are designed for keeping and handling sterile instruments and to facilitate their cleaning and decontamination. Some instrument tables are designed specifically for use in magnetic resonance imaging [MRI] environments, i.e., MRI-compatible Mayo stands, and are made from nonmagnetic materials so that they can be safely used in an MRI suite." + }, + { + "input": "Concept: Saridegib (Substance with smoothened receptor antagonist mechanism of action)", + "output": "something described as an orally bioavailable, cyclopamine-derived inhibitor of the Hedgehog (Hh) pathway with potential antineoplastic activity. Specifically, patidegib binds to and inhibits the cell membrane-spanning G-protein coupled receptor SMO, which may result in the suppression of Hh pathway signaling and a decrease in tumor cell proliferation and survival. SMO is activated upon binding of Hh ligand to the cell surface receptor Patched (PTCH); inappropriate activation of Hh signaling and uncontrolled cellular proliferation may be associated with SMO mutations. The Hh signaling pathway plays an important role in proliferation of neuronal precursor cells in the developing cerebellum and other tissues." + }, + { + "input": "Concept: 2,6-beta-fructan 6-levanbiohydrolase activity (Molecular Function)", + "output": "hydrolase activity, hydrolyzing O-glycosyl compounds described as catalysis of the hydrolysis of (2->6)-beta-D-fructofuranan, to remove successive disaccharide residues as levanbiose, i.e. 6-(beta-D-fructofuranosyl)-D-fructose, from the end of the chain." + }, + { + "input": "Concept: regulation of mononuclear cell migration (Cell Function)", + "output": "regulation of leukocyte migration described as any process that modulates the rate, frequency or extent of mononuclear cell migration. Mononuclear cell migration is the movement of a mononuclear cell within or between different tissues and organs of the body." + }, + { + "input": "Concept: Coccidioides immitis (Coccidioides sp.)", + "output": "Fungus described as a species of pathogenic fungus in the family Onygenaceae that is one of the causative agents of coccidioidomycosis. It is found in the soil in southwestern United States and northern Mexico." + }, + { + "input": "Concept: 5q35 (Cell Component)", + "output": "Chromosome band described as a chromosome band present on 5q" + }, + { + "input": "Concept: Streaming Video as Topic (Intellectual Product)", + "output": "something described as content sent in compressed form over the INTERNET and displayed by the viewer in real time." + }, + { + "input": "Concept: Duodenal Infection (Finding)", + "output": "something described as a disorder characterized by an infectious process involving the duodenum." + }, + { + "input": "Concept: Tumor Proportion Score (Finding)", + "output": "Cell Count described as the percentage of viable tumor cells with partial or complete cell membrane staining." + }, + { + "input": "Concept: DUSP3 (Enzyme)", + "output": "Enzyme described as dual specificity protein phosphatase 3 (185 aa, ~20 kDa) is encoded by the human DUSP3 gene. This protein plays a role in protein dephosphorylation." + }, + { + "input": "Concept: Ninth-Nerve Palsy, Traumatic (Cranial Nerve Injuries)", + "output": "Cranial Nerve Injuries described as traumatic injuries to the GLOSSOPHARYNGEAL NERVE." + }, + { + "input": "Concept: SSU rRNA binding (Genetic Function)", + "output": "something described as interacting selectively and non-covalently with the small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA." + }, + { + "input": "Concept: PODCI Adolescent Parent-Reported Version - Gym Limited by: Health (Intellectual Product)", + "output": "Intellectual Product described as pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported - If you answered \"sometimes\" or \"never or rarely\" to Question 66 above, was your child's activity limited by: General health?" + }, + { + "input": "Concept: Skin malformation (Congenital Systemic Disorder)", + "output": "Non-Neoplastic Skin Disorder described as structural abnormalities of the skin that exist at, and usually before, birth regardless of their causation." + }, + { + "input": "Concept: area 32 of Brodmann (Body Location or Region)", + "output": "something described as an earlier designation of area 25 of Brodmann (guenon) ( Garey-1999 )." + }, + { + "input": "Concept: StudyProtocolVersion.studySubjectTypeCode (Study Subject Type Code)", + "output": "Study Subject Type Code described as a coded value specifying the target entity of the study of investigation." + }, + { + "input": "Concept: down-regulation of calcium-independent cell-cell adhesion (Cell Function)", + "output": "something described as any process that stops, prevents, or reduces the frequency, rate or extent of calcium-independent cell-cell adhesion." + }, + { + "input": "Concept: Melanoma of the Skin pM1b(1) TNM Finding v8 (Cutaneous Melanoma pM1b TNM Finding v8)", + "output": "something described as cutaneous melanoma with distant metastasis to lung with or without M1a sites of disease. LDH level elevated." + }, + { + "input": "Concept: CPS01 (Research or Clinical Assessment Tool)", + "output": "something described as a standardized rating scale used to assess the severity of liver cirrhosis and determine the prognosis, the required strength of treatment, and the necessity of liver transplantation. This instrument uses the following clinical and lab criteria: encephalopathy grade, ascites, bilirubin, albumin, and prothrombin index." + }, + { + "input": "Concept: ETOPOSIDE TONIRIBATE (Pharmacologic Substance)", + "output": "Epipodophyllotoxin described as a prodrug of etoposide, a semisynthetic derivative of podophyllotoxin extracted from the mandrake root Podophyllum peltatum, with potential antineoplastic activity. Upon intravenous administration of etoposide toniribate, etoposide is released after enzymatic cleavage of CAP7.1 by specific carboxylesterases (CE) 1 and 2, which are upregulated in certain tumor cell types. Etoposide acts primarily in the G2 and S phases of the cell cycle. This drug binds to and inhibits topoisomerase II, an enzyme elevated in tumor cells. This results in the accumulation of double-strand DNA breaks, the inhibition of DNA replication and transcription and the induction of apoptotic cell death. The tumor-specific activation of etoposide increases its efficacy while lowering its systemic toxicity." + }, + { + "input": "Concept: Aggregation, Cell (cellular process)", + "output": "Cell Function described as the clustering together and adhesion of initially separate cells to form an aggregate. Examples include the clustering of unicellular organisms or blood cells in suspension and the condensation of mesenchymal cells during cartilage formation." + }, + { + "input": "Concept: Pentanes (Organic Chemical)", + "output": "Organic Chemical described as five-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives." + }, + { + "input": "Concept: placenta twin (Congenital malformation of genital organs)", + "output": "Placental abnormalities described as a variant placenta in which the chorionic tissue is partitioned into two distinct discs, without consistent relationship to umbilical cord insertion." + }, + { + "input": "Concept: N5-methyltetrahydromethanopterin--coenzyme M methyltransferase activity (S-methyltransferase activity)", + "output": "something described as catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme M = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M. 2-(methylthio)ethanesulfonate is also known as methyl-CoM." + }, + { + "input": "Concept: T-Lymphocyte Count (Lymphocyte Count measurement)", + "output": "White blood cell analyses described as a measurement of the total thymocyte-derived lymphocytes in a biological specimen." + }, + { + "input": "Concept: Support Belts, Abdominal (Materials and/or supplies)", + "output": "Body support device described as binders designed to encircle the abdomen to provide support to the abdominal walls and keep the abdomen in the appropriate position. These devices are usually made of wide flexible pieces of elastic fabric with hook-and-loop closures (e.g., Velcro) or metal fasteners with small teeth that grab onto and secure the elastic fabric for adjustment of the size of the binders; the binders are available in several sizes. Abdominal binders are used to support and compress the abdominal muscles and other abdominal structures for rehabilitation after childbirth or abdominal surgery (e.g., liposuction); the binders may be also used by women after labor to support the relaxed abdominal walls. They may also provide relief from pain and strain." + }, + { + "input": "Concept: poly(ADP-ribose) polymerase 1 (Gene or Genome)", + "output": "Gene or Genome described as this gene is involved in cellular repair and apoptosis." + }, + { + "input": "Concept: Ophthalmotropometers (Ophthalmic device)", + "output": "Medical Device described as ophthalmic instruments designed to measure the amount of misalignment of the eyes (strabismus). Automated instruments use light sources, light sensors, and data analyzers to produce images and measure the light reflection from the corneas, as well as the pupils of both eyes; manual instruments typically consist of an illuminated screen that presents light stimuli, the examinee wears special eyeglasses (so the green light stimuli is perceived as red light) and points a handheld laser flashlight at the screen. The examiner performs the assessment by comparing the actual location of the green light and the perceived location of red light by the patient. Ophthalmotropometers are used to detect and assess the magnitude of strabismus." + }, + { + "input": "Concept: activin binding protein (Binding Proteins)", + "output": "Regulatory Protein described as follistatin (344 aa, ~38 kDa) is encoded by the human FST gene. This protein is involved in inhibiting both activin-mediated cell growth and follicle-stimulating hormone release." + }, + { + "input": "Concept: WD7-Staying by Yourself for a Few Days (Intellectual Product)", + "output": "something described as world Health Organization Disability Assessment Schedule 2.0 36-item Version Self-administered (WHODAS 2.0 36-item Version Self-administered) In the past 30 days, how much difficulty did you have in: Staying by yourself for a few days?" + }, + { + "input": "Concept: Epidemiology Nursing (Biomedical Occupation or Discipline)", + "output": "something described as the application of nursing principles to the study of the patterns of disease or other events across populations." + }, + { + "input": "Concept: S-succinyltransferase activity (Molecular Function)", + "output": "something described as catalysis of the transfer of a succinyl group to a sulfur atom on the acceptor molecule." + }, + { + "input": "Concept: Exclude Food and Water Consumption Data From Statistics Indicator (Exclude from Statistics Indicator)", + "output": "something described as specifies whether the food and water consumption result values should be excluded from the statistical analysis." + }, + { + "input": "Concept: Planned Criterion Group Composition Relationship (Qualitative Concept)", + "output": "Qualitative Concept described as a relationship between a planned criterion group and a planned activity, planned observation result or other planned criterion group that is a component, i.e. a relationship between a logical set of parenthesis and one of the items inside the parentheses. EXAMPLE(S): A battery of tests may be composed of multiple routine labs that are always ordered together as a group. A glucose tolerance test which is comprised of administering glucose and taking multiple timed blood samples which are then tested for glucose. NOTE(S): This class helps represent an AND relationship between siblings in the same criterion group." + }, + { + "input": "Concept: succinyl semialdehyde dehydrogenase activity (Molecular Function)", + "output": "something described as catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+." + }, + { + "input": "Concept: benzylpenicillin acylase activity (Molecular Function)", + "output": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides described as catalysis of the reaction: penicillin + H2O = a carboxylate + 6-aminopenicillanate." + }, + { + "input": "Concept: 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatases Isoform 3 Inhibitor ACT-PFK-158 (Enzyme Inhibitor Drugs)", + "output": "Enzyme Inhibitor Drugs described as an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFK-2/FBPase) isoform 3 (PFKFB3) and derivative of 3-(3-pyridinyl)-1-[4-pyridinyl]-2-propen-1-one (3PO), with potential antineoplastic activity. Upon administration, PFKFB3 inhibitor PFK-158 binds to and inhibits the activity of PFKFB3, which leads to the inhibition of both the glycolytic pathway in and glucose uptake by cancer cells. This prevents the production of macromolecules and energy that causes the enhanced cellular proliferation in cancer cells as compared to that of normal, healthy cells. Depriving cancer cells of nutrients and energy leads to the inhibition of cancer cell growth. PFKFB3, an enzyme that catalyzes the conversion of fructose-6-phosphate to fructose-2,6-bisphosphate, is highly expressed and active in human cancer cells; it plays a key role in increasing both glycolytic flux in and proliferation of cancer cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C113787\" active clinical trials using this agent." + }, + { + "input": "Concept: Accessory nostril (Congenital anomaly of upper respiratory system)", + "output": "Disorder of nasal cavity described as the presence of more than two nostrils." + }, + { + "input": "Concept: Can you talk about sexuality with your partner or the person who is closest to you (Intellectual Product)", + "output": "Clinical or Research Assessment Question described as a question about whether an individual can talk about sexuality with their partner or the person who is closest to them." + }, + { + "input": "Concept: Spinal Dysraphisms (Bone Diseases, Developmental)", + "output": "Vertebral column described as a family of defects in the closure of the spinal column. May be covered with skin (spina bifida occulta) or not covered with skin (spinabifida aperta); may involve protrusion of spinal cord and/or meninges. (Makris S, Solomon HM, Clark R, Shiota K, Barbellion S, Buschmann J, Ema M, Fujiwara M, Grote K, Hazelden KP, Hew KW, Horimoto M, Ooshima Y, Parkinson M, Wise LD. Terminology of developmental abnormalities in common laboratory mammals (Version 2). Part B. Birth Defects Res B Dev Reprod Toxicol. 2009 Aug;86(4):227-327.)" + }, + { + "input": "Concept: Numerosity Perception (Perception)", + "output": "Mental Process described as perception of quantities in stimulus sets in visual, auditory, or other perceptual modes." + }, + { + "input": "Concept: epidermodysplasia verruciformis (Skin Diseases, Viral)", + "output": "Hereditary disorder of the integument described as an autosomal recessive trait with impaired cell-mediated immunity. About 15 human papillomaviruses are implicated in associated infection, four of which lead to skin neoplasms. The disease begins in childhood with red papules and later spreads over the body as gray or yellow scales." + }, + { + "input": "Concept: alv (Body Location or Region)", + "output": "Midline anatomical point of skull described as midline anatomical point of skull where a line drawn through the most posterior points of alveolar ridges crosses the midline." + }, + { + "input": "Concept: sensory neuropathy (Peripheral Nervous System)", + "output": "Sensory neuropathy described as peripheral neuropathy affecting the sensory nerves." + }, + { + "input": "Concept: avapritinib (Enzyme Inhibitors)", + "output": "Protein-tyrosine kinase inhibitor described as an orally bioavailable inhibitor of specific mutated forms of platelet-derived growth factor receptor alpha (PDGFR alpha; PDGFRa) and mast/stem cell factor receptor c-Kit (SCFR), with potential antineoplastic activity. Upon oral administration, avapritinib specifically binds to and inhibits specific mutant forms of PDGFRa and c-Kit, including the PDGFRa D842V mutant and various KIT exon 17 mutants. This results in the inhibition of PDGFRa- and c-Kit-mediated signal transduction pathways and the inhibition of proliferation in tumor cells that express these PDGFRa and c-Kit mutants. PDGFRa and c-Kit, protein tyrosine kinases and tumor-associated antigens (TAAs), are mutated in various tumor cell types; they play key roles in the regulation of cellular proliferation." + }, + { + "input": "Concept: Electronic Format (Manufactured form)", + "output": "Manufactured form described as a questionnaire or measure that is administered on an electronic device, such as a computer, tablet, or smartphone." + }, + { + "input": "Concept: red mangrove family (Angiosperm)", + "output": "Plant described as a plant family of the order Rhizophorales, subclass Rosidae, class Magnoliopsida, that includes mangrove trees." + }, + { + "input": "Concept: Sanfilippo syndrome (Disease or Syndrome)", + "output": "Disease or Syndrome described as mucopolysaccharidosis characterized by heparin sulfate in the urine, progressive mental retardation, mild dwarfism, and other skeletal disorders." + }, + { + "input": "Concept: Approved for Non-Human Use Product (Status)", + "output": "Qualitative Concept described as a product has been approved for use in non-humans." + }, + { + "input": "Concept: MLL/MLLT3 Fusion Protein Expression (Cell or Molecular Dysfunction)", + "output": "something described as expression of a fusion protein that results from a t(9;11)(p22;q23) translocation, which involves the human genes KMT2A and MLLT3 and is associated with many leukemias." + }, + { + "input": "Concept: UDP-Gal:BetaGlcNAc Beta 1,4- Galactosyltransferase, Polypeptide 1 wt Allele (Gene or Genome)", + "output": "something described as human B4GALT1 wild-type allele is located in the vicinity of 9p13 and is approximately 63 kb in length. This allele, which encodes beta-1,4-galactosyltransferase 1 protein, is involved in lactose synthesis. Mutation of the gene is associated with congenital disorder of glycosylation type 2D." + }, + { + "input": "Concept: Deoxyribonucleic Acid Sequencing (Laboratory Procedure)", + "output": "something described as the determination of the sequence of purines and pyrimidines in deoxyribonucleic acid (DNA)." + }, + { + "input": "Concept: Treatment Resistant Disorders (Disorder Characteristics)", + "output": "Disorder Characteristics described as used for any disorder that is resistant to any type of psychological or medical treatment." + }, + { + "input": "Concept: Clinical Trial Site Training Material (Intellectual Product)", + "output": "something described as a collection of materials used to train sites, including but not limited to electronic data capture (EDC) training." + }, + { + "input": "Concept: ANTIGEN, AGGLUTINATING, ECHINOCOCCUS SPP. (Indicator, Reagent, or Diagnostic Aid)", + "output": "Indicator, Reagent, or Diagnostic Aid described as echinococcus spp. serological reagents are devices that consist of Echinococcus spp. antigens and antisera used in serological tests to identify antibodies to Echinococcus spp. in serum. The identification aids in the diagnosis of echinococcosis, caused by parasitic tapeworms belonging to the genus Echinococcus and provides epidemiological information on this disease. Echinococcosis is characterized by the development of cysts in the liver, lung, kidneys, and other organs formed by the larva of the infecting organisms." + }, + { + "input": "Concept: High Grade Fallopian Tube Serous Adenocarcinoma (Fallopian Tube Serous Adenocarcinoma)", + "output": "something described as a rapidly growing serous adenocarcinoma that arises from the fallopian tube. It is characterized by the presence of high grade cytologic features and frequent mitotic figures." + }, + { + "input": "Concept: S-adenosyl-L-methionine:precorrin-4 C11 methyltransferase activity (Molecular Function)", + "output": "something described as catalysis of the reaction: S-adenosyl-L-methionine + precorrin-4 = S-adenosyl-L-homocysteine + precorrin 5." + }, + { + "input": "Concept: Pesticide product (Agrochemical biocide)", + "output": "Substance categorized functionally described as chemicals used to destroy pests of any sort. The concept includes fungicides (FUNGICIDES, INDUSTRIAL); INSECTICIDES; RODENTICIDES; etc." + }, + { + "input": "Concept: Outlier (Quantitative Concept)", + "output": "Quantitative Concept described as values outside of an expected range." + }, + { + "input": "Concept: cdc Proteins (Proteins)", + "output": "Regulatory Protein described as proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS." + }, + { + "input": "Concept: Ureter Urothelial Papilloma (Bladder papilloma)", + "output": "Bladder papilloma described as a benign epithelial neoplasm that produces visible warty projections from the epithelial surface of the ureter." + }, + { + "input": "Concept: breast duct endoscopy (Diagnostic Procedure)", + "output": "something described as a method used to examine the lining of the breast ducts to look for abnormal tissue. A very thin, flexible, lighted tube attached to a camera is inserted through the nipple, and threaded into the breast ducts deep in the breast. Tissue and fluid samples may be removed during the procedure." + }, + { + "input": "Concept: proton-dependent oligopeptide secondary active transmembrane transporter activity (secondary active oligopeptide transmembrane transporter activity)", + "output": "secondary active oligopeptide transmembrane transporter activity described as enables the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement." + }, + { + "input": "Concept: Bartonellaceae (Bacterium)", + "output": "Alphaproteobacteria described as a taxonomic family of pathogenic bacterium in the phylum Proteobacteria that includes the genus Bartonella." + }, + { + "input": "Concept: idarubicin HCl (idarubicin)", + "output": "I [Preparations] described as the hydrochloride salt of the anthracycline antineoplastic antibiotic idarubicin. Idarubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. Due to its high lipophilicity, idarubicin penetrates cell membranes more efficiently than other anthracycline antibiotic compounds" + }, + { + "input": "Concept: XECD (Chandler syndrome)", + "output": "Congenital Disorders described as a rare subtype of posterior corneal dystrophy with characteristics of congenital ground glass corneal clouding or a diffuse corneal haze, and blurred vision in male patients. Prevalence of this rare corneal dystrophy is unknown. Males are affected more severely than females. The condition is progressive in males and non-progressive in females. Has been mapped to the long arm of the X-chromosome (Xq25) but the causative gene has not been identified. Transmission is X-linked recessive." + }, + { + "input": "Concept: ANTISERA, NEUTRALIZATION, ADENOVIRUS 1-33 (Immunologic Factor)", + "output": "Indicator, Reagent, or Diagnostic Aid described as adenovirus serological reagents are devices that consist of antigens and antisera used in serological tests to identify antibodies to adenovirus in serum. Additionally, some of these reagents consist of adenovirus antisera conjugated with a fluorescent dye and are used to identify adenoviruses directly from clinical specimens. The identification aids in the diagnosis of disease caused by adenoviruses and provides epidemiological information on these diseases. Adenovirus infections may cause pharyngitis (inflammation of the throat), acute respiratory diseases, and certain external diseases of the eye (e.g., conjunctivitis)." + }, + { + "input": "Concept: Lipoma of Epicardium (Cardiac Lipoma)", + "output": "Benign neoplasm of epicardium described as a rare benign adipose tissue neoplasm of the epicardium of the heart." + }, + { + "input": "Concept: FAC061-Trouble Meeting Needs of Family (FACT-BMT Version 4 Questionnaire Question)", + "output": "FACT-BMT Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Bone Marrow Transplant Version 4 - Because of my physical condition, I have trouble meeting the needs of my family." + }, + { + "input": "Concept: contractile actin filament bundle assembly (Cell Function)", + "output": "actin filament bundle assembly described as assembly of actin filament bundles in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle." + }, + { + "input": "Concept: University of Pittsburgh Cancer Institute (NCI-Designated Comprehensive Cancer Center)", + "output": "something described as the mission of the University of Pittsburgh Cancer Institute is to decrease the mortality and morbidity from cancer across the nation, and especially in western Pennsylvania, through integrated programs in basic, clinical, translational, and population and cancer control research. The Institute maintains a comprehensive approach to understanding and defeating cancer. It was named an NCI-designated comprehensive cancer center in 1989." + }, + { + "input": "Concept: Spatial Regressions (Quantitative Concept)", + "output": "Spatial Analysis described as methods used to take into account and incorporate spatial autocorrelation and regional variation into regression analysis models of data that has spatial dependency, and also to provide information on the spatial relationships among the variables." + }, + { + "input": "Concept: medical fee (Fees and Charges)", + "output": "Medical Economics described as amounts charged to the patient as payer for medical services." + }, + { + "input": "Concept: Rexed's lamina VIII (gray spinal laminae)", + "output": "Body Part, Organ, or Organ Component described as a subdivision of the spinal central gray defined on the basis of cytoarchitecture. Located in the anterior gray column of the spinal cord, it varies in size. In the cervical enlargement and lumbar enlargement it occupies only the medial part of the column; at other levels it extends across the entire width of the column. It is bounded by lamina VII posterolaterally, and slender columns of lamina IX are embedded in it ( Carpenter-1983 )." + }, + { + "input": "Concept: INTERFERON REGULATORY FACTOR 6 (TRANSCRIPTION FACTOR)", + "output": "Transcription factor genes described as interferon regulatory factor 6 (467 aa, ~53 kDa) is encoded by the human IRF6 gene. This protein plays a role in the regulation of transcription." + }, + { + "input": "Concept: mRNA transport (Cell Function)", + "output": "something described as the directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." + }, + { + "input": "Concept: PURIFIER, AIR, ULTRAVIOLET, MEDICAL (Medical Device)", + "output": "something described as a medical ultraviolet air purifier is a device intended for medical purposes that is used to destroy bacteria in the air by exposure to ultraviolet radiation." + }, + { + "input": "Concept: Ingested (Physiological action)", + "output": "Mechanism described as taking food or nutrients into the body" + }, + { + "input": "Concept: CRANIAL NERVE II OPTIC NEURITIS (Optic Neuropathy)", + "output": "Inflammatory disease of the central nervous system described as inflammation of the second cranial nerve or optic nerve; commonly associated conditions include autoimmune disorders such as multiple sclerosis, infections, and granulomatous diseases." + }, + { + "input": "Concept: AIP5 (ubiquitin-protein ligase)", + "output": "Amino Acid, Peptide, or Protein described as NEDD4-like E3 ubiquitin-protein ligase WWP1 (922 aa, ~105 kDa) is encoded by the human WWP1 gene. This protein plays a role in the mediation of protein ubiquitination." + }, + { + "input": "Concept: Deubiquitinating Enzymes (Amino Acid, Peptide, or Protein)", + "output": "Enzymes described as enzymes that remove UBIQUITIN from a protein substrate, including POLYUBIQUITIN, or from other molecules." + }, + { + "input": "Concept: Upper vermilion midline (Fiat anatomical line of head)", + "output": "Fiat anatomical line of head described as fiat anatomical line of head bounded by labiale superius and stomion." + }, + { + "input": "Concept: Neuronal Transmission (multicellular organismal signaling)", + "output": "something described as any process in which a presynaptic cell transfers a signal to a postsynaptic cell, by either release of a neurotransmitter or by passage of an electrical current via specialized channels. This process is essential to all neuronal functions." + }, + { + "input": "Concept: himalaya proselect koflet ea (Clinical Drug)", + "output": "something described as himalaya ProSelect(TM) Koflet 24 lozenges. UPC Code 605069121590." + }, + { + "input": "Concept: neurobiochemistry (Biomedical Occupation or Discipline)", + "output": "Biochemistry described as chemical makeup and metabolism of nervous tissue. Used for the scientific discipline or the neurochemical processes themselves." + }, + { + "input": "Concept: NORSE - new-onset refractory status epilepticus (Status Epilepticus)", + "output": "Acute nervous system disorder described as an acute encephalopathy with inflammation-mediated status epilepticus characterized by an acute refractory status epilepticus, typically of the tonic-clonic type, following prodromal symptoms of confusion, fever, fatigue, headache, symptoms of gastrointestinal or upper respiratory tract infection, behavioral changes or hallucinations. Brain MRI abnormalities and abnormal findings in cerebrospinal fluid, including pleocytosis and/or elevated protein levels, are frequently found during acute episode. Treatment-resistant epilepsy, cognitive and psychiatric impairments are usual consequences." + }, + { + "input": "Concept: Activated PTT/Standard PTT (Blood coagulation tests)", + "output": "Chemical procedure described as a relative measurement (ratio or percentage) of the subject's partial thromboplastin time to a standard or control partial thromboplastin time." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Microbiology, Control, Blood Culture Media (IVD Test Reagent/Kits, Microbiology, Control)", + "output": "Medical Device described as reagents consisting of substances of known concentrations that are assayed by the usual clinical laboratory methods and that resemble the unknown specimen; they are used for quality control of a liquid medium capable of supporting the growth of microorganisms, particularly bacteria that may be present in the circulating blood; these controls may be specific either for manual or automated tests." + }, + { + "input": "Concept: SRT (Research or Clinical Assessment Tool)", + "output": "Research or Clinical Assessment Tool described as an 18-item imitation task that assesses a speaker's ability to repeat nonwords. This nonword repetition task was designed specifically for speakers whose incomplete inventories invalidate use of conventional nonword repetition tasks and/or who have speech production patterns that are difficult to transcribe and score." + }, + { + "input": "Concept: negative regulation of calcium ion transmembrane transporter activity (negative regulation of calcium ion transmembrane transport)", + "output": "regulation of calcium ion transmembrane transporter activity described as any process that stops, prevents or reduces the frequency, rate or extent of calcium ion transmembrane transporter activity." + }, + { + "input": "Concept: Q-LES-Q - Felt Satisfied With Your Life (Q-LES-Q Questionnaire Question)", + "output": "Q-LES-Q Questionnaire Question described as quality Of Life Enjoyment And Satisfaction Questionnaire (Q-LES-Q) During the past week how much of the time have you: felt satisfied with your life?" + }, + { + "input": "Concept: Hyperthyroids (Thyroid hyperfunction disorders)", + "output": "Non-Neoplastic Endocrine Disorder described as an abnormality of thyroid physiology characterized by excessive secretion of the thyroid hormones thyroxine (i.e., T4) and/or 3,3',5-triiodo-L-thyronine zwitterion (i.e., triiodothyronine or T3)." + }, + { + "input": "Concept: Simian Acquired Immuno Deficiency Syndrome (Lentivirus Infections)", + "output": "Retroviridae Infections described as acquired defect of cellular immunity that occurs naturally in macaques infected with SRV serotypes, experimentally in monkeys inoculated with SRV or Mason-Pfizer monkey virus; (MPMV), or in monkeys infected with SIV." + }, + { + "input": "Concept: Odontoblast (General ecto-epithelial cell)", + "output": "General ecto-epithelial cell described as the mesenchymal cells which line the DENTAL PULP CAVITY and produce DENTIN. They have a columnar morphology in the coronal pulp but are cuboidal in the root pulp, or when adjacent to tertiary dentin." + }, + { + "input": "Concept: APEX (Intellectual Product)", + "output": "something described as the exposure domain for those persons associated with the study itself, a particular study subject, or a device used in the study." + }, + { + "input": "Concept: osteoblast proliferation (cell population proliferation)", + "output": "cell population proliferation described as the multiplication or reproduction of osteoblasts, resulting in the expansion of an osteoblast cell population. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." + }, + { + "input": "Concept: SMBTST (Intellectual Product)", + "output": "something described as terminology associated with the SEND microbiology test name codelist of the Clinical Data Interchange Standards Consortium (CDISC) Standard for the Exchange of Non-clinical Data (SEND)." + }, + { + "input": "Concept: catecholamine binding (organic cyclic compound binding)", + "output": "organic cyclic compound binding described as interacting selectively and non-covalently with catecholamine." + }, + { + "input": "Concept: Autologous OC-L Vaccine (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as an autologous cancer vaccine composed of oxidized ovarian tumor cell lysate, with potential immunostimulatory and antineoplastic activities. Upon administration, the autologous oxidized ovarian tumor cell lysate vaccine exposes the immune system to an undefined amount of tumor-associated antigens (TAAs), which may result in the induction of both anti-tumor cytotoxic T-lymphocytes (CTLs) and antibody-dependent responses against TAA-expressing cells, leading to tumor cell lysis. Compared to non-oxidized tumor cell lysate vaccines, oxidized tumor cell lysate vaccines induce necrotic cell death, increase the immunogenicity of the TAAs and may enhance the anti-tumor immune response. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C122402\" active clinical trials using this agent." + }, + { + "input": "Concept: Hematopoietic and Lymphoid System Disorder (MeSH Spanish)", + "output": "Japanese translation of the Medical Subject Headings described as any deviation from the normal structure or function of the blood or lymphatic system that is manifested by a characteristic set of symptoms and signs." + }, + { + "input": "Concept: Weakness of orbicularis oculi muscles (Finding)", + "output": "something described as reduced strength of the orbicularis oculi, the circumorbital muscle in the face that closes the eyelid." + }, + { + "input": "Concept: DILATOR, VESSEL (Medical Device)", + "output": "Medical Device described as a blood access device and accessories is a device intended to provide access to a patient's blood for hemodialysis or other chronic uses. When used in hemodialysis, it is part of an artificial kidney system for the treatment of patients with renal failure or toxemic conditions and provides access to a patient's blood for hemodialysis. The device includes implanted blood access devices, nonimplanted blood access devices, and accessories for both the implanted and nonimplanted blood access devices. (1) The implanted blood access device consists of various flexible or rigid tubes, which are surgically implanted in appropriate blood vessels, may come through the skin, and are intended to remain in the body for 30 days or more. This generic type of device includes various shunts and connectors specifically designed to provide access to blood, such as the arteriovenous (A - V) shunt cannula and vessel tip. (2) The nonimplanted blood access device consists of various flexible or rigid tubes, such as catheters, cannulae or hollow needles, which are inserted into appropriate blood vessels or a vascular graft prosthesis (Secs. 870.3450 and 870.3460), and are intended to remain in the body for less than 30 days. This generic type of device includes fistula needles, the single needle dialysis set (coaxial flow needle), and the single needle dialysis set (alternating flow needle). (3) Accessories common to either type include the shunt adaptor, cannula clamp, shunt connector, shunt stabilizer, vessel dilator, disconnect forceps, shunt guard, crimp plier, tube plier, crimp ring, joint ring, fistula adaptor, and declotting tray (including contents)." + }, + { + "input": "Concept: Cutaneous Squamous Cell Carcinoma of the Head and Neck pN3b TNM Finding v8 (Finding)", + "output": "Cutaneous Squamous Cell Carcinoma of the Head and Neck pN3 TNM Finding v8 described as cutaneous squamous cell carcinoma of the head and neck with metastasis in a single ipsilateral lymph node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral, or bilateral lymph nodes, any with ENE(+)." + }, + { + "input": "Concept: Vaccines, Diphtheria-Tetanus-acellular Pertussis (Pharmacologic Substance)", + "output": "Vaccines, Combined described as combined vaccines consisting of DIPHTHERIA TOXOID; TETANUS TOXOID; and an acellular form of PERTUSSIS VACCINE. At least five different purified antigens of B. pertussis have been used in various combinations in these vaccines." + }, + { + "input": "Concept: CTP Synthetase Inhibitors (Enzyme Inhibitor Drugs)", + "output": "Enzyme Inhibitor Drugs described as any substance that inhibits cytidine triphosphate synthetase, an enzyme that catalyses the rate-limiting step in the synthesis of CTP. Inhibition of cytidine triphosphate synthetase interferes with DNA, RNA, and CTP biosynthesis and can cause cell cycle arrest." + }, + { + "input": "Concept: glutaminase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)", + "output": "something described as catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3." + }, + { + "input": "Concept: Icosahedral Cytoplasmic Deoxyriboviruses (DNA Viruses)", + "output": "DNA Viruses described as a family of large icosahedral DNA viruses infecting insects and poikilothermic vertebrates. Genera include IRIDOVIRUS; RANAVIRUS; Chloriridovirus; Megalocytivirus; and Lymphocystivirus." + }, + { + "input": "Concept: ginseng compound (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as a compound containing the traditional Chinese medicine (TCM) ginseng, a herb belonging to the Araliaceae family, with potential antioxidant, chemopreventive, anti-inflammatory and antineoplastic activities. Upon administration of the ginseng compound, the active ingredients, mainly ginsenosides, inhibit various signal transduction pathways that play key roles in carcinogenesis and inflammation. This leads to the induction of apoptosis in and inhibits proliferation of tumor cells. In addition, ginsenosides enhance the activity of various antioxidant enzymes, induce nitric oxide (NO) formation, inhibit the formation of reactive oxygen species (ROS) and protect against free radical-induced DNA damage. Ginseng also modulates various components of the immune system, including the activation of dendritic cells (DCs)." + }, + { + "input": "Concept: Coagulation Analyzers, Manual (Medical Device)", + "output": "something described as laboratory blood coagulation analyzers that require the manual addition of reagents and specimens, processing smaller batches of specimens than automated analyzers. Most analyzers require previous centrifugation of the sample to obtain plasma samples. Semiautomated blood coagulation analyzers include an incubation container (e.g., test tube), timing devices, a clot formation detector (e.g., using photometric, electrical impedance, or mechanical impedance), and usually, some computerized capabilities for sample handling and data management. These analyzers are used in laboratories with medium or light workloads where specimens are usually tested individually, although some semiautomated analyzers can process several samples simultaneously." + }, + { + "input": "Concept: CDC Enteric Group 46 (Moellerella)", + "output": "Moellerella described as a species of facultatively anaerobic, Gram negative, rod shaped bacterium in the phylum Proteobacteria. This species is nonmotile, indole negative, resistant to colistin, lactose positive and produces acid from D-glucose, lactose and raffinose. M. wisconsensis is found in water and may be associated with diarrheal symptoms in humans." + }, + { + "input": "Concept: FAC02332 (Intellectual Product)", + "output": "FACT-P Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Prostate Version 4 (FACT-P Version 4) Additional Concerns: My pain keeps me from doing things I want to do." + }, + { + "input": "Concept: Tibialis (Body Part, Organ, or Organ Component)", + "output": "Body Part, Organ, or Organ Component described as referencing either the anterior tibialis muscle or the posterior tibialis muscle, which are muscles of the lower leg." + }, + { + "input": "Concept: interleukin-6 receptor binding (growth factor receptor binding)", + "output": "something described as interacting selectively and non-covalently with the interleukin-6 receptor." + }, + { + "input": "Concept: Postcataract Aphakias (Acquired Abnormality)", + "output": "Acquired Abnormality described as absence of the crystalline lens resulting from cataract extraction." + }, + { + "input": "Concept: Self-Management: Chronic Disease (Health management)", + "output": "Finding described as personal actions to manage a chronic disease, its treatment, and to prevent disease progression and complications" + }, + { + "input": "Concept: Partial duplication of outermost little finger bone (Anatomical Abnormality)", + "output": "something described as partial duplication of the distal phalanx of little finger, seen on x-rays as a broad and/or bifid phalanx." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, CLCNKB (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication described as molecular assay reagents intended to identify deletions or duplications of the chloride voltage-gated channel Kb (CLCNKB) gene, located at chromosome 1p36, which encodes the protein chloride channel protein ClC-Kb. Genetic variants at this locus have been associated with Bartter syndrome." + }, + { + "input": "Concept: Intrahepatic Bile Duct Cancer pTis TNM Finding v7 (Intrahepatic Bile Duct Cancer Pathologic Primary Tumor TNM Finding v7)", + "output": "Finding described as intrahepatic bile duct cancer with a finding of carcinoma in situ (intraductal tumor)." + }, + { + "input": "Concept: mannosyl-oligosaccharide mannosidase activity (alpha-mannosidase activity)", + "output": "alpha-mannosidase activity described as catalysis of the hydrolysis of the terminal alpha-D-mannose residues in oligo-mannose oligosaccharides." + }, + { + "input": "Concept: Urrets Zavalia syndrome (Congenital anomaly of orbit)", + "output": "something described as syndromic orbital border hypoplasia is a rare disorder observed in two families to date with characteristics of agenesis of the orbital margin, varying defects of the lacrimal passages, hypoplasia of the palpebral skin and tarsal plates and atresia of the nasolacrimal duct." + }, + { + "input": "Concept: Infiltrating Mixed Breast Carcinoma (Neoplastic Process)", + "output": "something described as an invasive breast carcinoma characterized by the presence of more than one malignant epithelial histologic pattern." + }, + { + "input": "Concept: L-xylitol breakdown (pentitol catabolic process)", + "output": "L-xylitol metabolic process described as the chemical reactions and pathways resulting in the breakdown of L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group." + }, + { + "input": "Concept: Brains, Hind (Brain part)", + "output": "Brain Stem described as part of the brain developed from the posterior of the three primary brain vesicles of the embryonic neural tube; it comprises the metencephalon (cerebellum and pons) and myelencephalon (medulla oblongata)." + }, + { + "input": "Concept: mitochondrial NAD transmembrane transport (Cell Function)", + "output": "something described as the process in which NAD is transported across a mitochondrial membrane, into or out of the mitochondrion." + }, + { + "input": "Concept: Reduced carnitine O-palmitoyltransferase level (Finding)", + "output": "Finding described as reduced carnitine O-palmitoyltransferase level, leading to a reduced activity of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine." + }, + { + "input": "Concept: ELISA self designed, base 11 (Allergy testing)", + "output": "something described as analyzing a client/patient's blood, hair, urine and/or other sample to assess his or her allergic response(s) to 11 or more unspecified antigens using the base test of an ELISA/ACT(R) Screening Self-Designed Block. Service is billed per base test." + }, + { + "input": "Concept: response to laminar fluid shear stress (response to fluid shear stress)", + "output": "something described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers. As an example, laminar shear stress can be seen where blood flows against the luminal side of blood vessel walls." + }, + { + "input": "Concept: TFG/NOR1 Fusion Gene (Signaling Pathway Gene)", + "output": "Signaling Pathway Gene described as this gene is involved in signaling." + }, + { + "input": "Concept: Thyroid hormone receptor site (Proto-Oncogene Proteins)", + "output": "Proto-Oncogene Proteins described as specific high affinity binding proteins for THYROID HORMONES in target cells. They are usually found in the nucleus and regulate DNA transcription. These receptors are activated by hormones that leads to transcription, cell differentiation, and growth suppression. Thyroid hormone receptors are encoded by two genes (GENES, ERBA): erbA-alpha and erbA-beta for alpha and beta thyroid hormone receptors, respectively." + }, + { + "input": "Concept: Glucagon-Like Peptide-1, Inactive Form (Laboratory Procedure)", + "output": "Protein or Enzyme Type Measurement described as a measurement of the inactive form of glucagon-like peptide-1 in a biological specimen." + }, + { + "input": "Concept: QCT (Diagnostic Procedure)", + "output": "Diagnostic Procedure described as a type of computed tomography in which a calibration standard correlates radiodensity values to quantitative tissue density values." + }, + { + "input": "Concept: 3-26-27 MYOCARDITIDES (Inflammation of specific body systems)", + "output": "Structural disorder of heart described as inflammation of the heart muscle" + }, + { + "input": "Concept: downregulation of membrane potential (regulation of membrane potential)", + "output": "something described as any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." + }, + { + "input": "Concept: {Kit} (Unit dose)", + "output": "Potency Unit described as a dosing measurement based on the kit unit." + }, + { + "input": "Concept: deciliter (Quantitative Concept)", + "output": "Quantitative Concept described as the unit of volume equal to one tenth of a liter. Accepted for use with the SI." + }, + { + "input": "Concept: transitive RNAi (Genetic Function)", + "output": "RNA Interference described as an RNA interference where the silencing signal spreads along the target mRNA in a 5' or 3' direction, outside of the initial target sequence." + }, + { + "input": "Concept: Transcription Factor, SOX8 (TRANSCRIPTION FACTOR)", + "output": "something described as transcription factor SOX-8 (446 aa, ~47 kDa) is encoded by the human SOX8 gene. This protein is involved in the activation of transcription." + }, + { + "input": "Concept: anti-gout agents colchicinum (Allergen class)", + "output": "something described as a drug used to treat gout (inflamed joints caused by a buildup of uric acid). It comes from the crocus plant Colchicum autumnale. Colchicine blocks cell division and the movement of certain immune cells to areas that are inflamed. It is a type of alkaloid and a type of mitotic inhibitor." + }, + { + "input": "Concept: Visual Analog Scale (Intellectual Product)", + "output": "Intellectual Product described as a questionnaire, rating and scale (QRS) data type using a visual analog scale (VAS) 50 mm scale." + }, + { + "input": "Concept: aml (Lamina of cerebral hemisphere)", + "output": "something described as a thin white layer that subdivides the medial segment of the globus pallidus into the inner portion of the medial globus pallidus and the outer portion of the medial globus pallidus ( Carpenter-1983 )." + }, + { + "input": "Concept: Genetic selection (Genetic Processes)", + "output": "Genetic finding described as differential and non-random reproduction of different genotypes, operating to alter the gene frequencies within a population." + }, + { + "input": "Concept: Physical Therapy Techniques (Rehabilitation therapy)", + "output": "Therapeutic or Preventive Procedure described as therapeutic modalities frequently used in PHYSICAL THERAPY SPECIALTY by PHYSICAL THERAPISTS or physiotherapists to promote, maintain, or restore the physical and physiological well-being of an individual." + }, + { + "input": "Concept: Cysts, CNS (Space-occupying lesion of nervous system)", + "output": "mass lesion of central nervous system described as a congenital or acquired cyst that is present in the central nervous system." + }, + { + "input": "Concept: Insufficient biological width (Alveolar ridge abnormality)", + "output": "Disease or Syndrome described as insufficient distance between the peri-implant mucosa margin and the bone crest." + }, + { + "input": "Concept: Combined Automated/Manual External Defibrillators (Defibrillators, External)", + "output": "something described as external defibrillators that combine in one unit the capabilities of automated and manual defibrillators. Automated mode operation of these defibrillators only requires the user to apply the electrodes to the patient's thorax and follow the voice prompts and/or on-screen messages. Then the defibrillators analyze the ECG rhythm to determine if a defibrillation shock is needed; if it is, the defibrillator warns the operator and automatically charges and discharges. When operated in manual mode the defibrillators require the operator to observe the ECG waveform, confirm ventricular fibrillation, and perform the necessary operations to apply the selected level of stored energy through the paddles to the thorax of the patient; the device may also provide cardioversion in manual mode. Combined automated/manual defibrillators usually include an electrocardiographic monitor as an integral part. The devices are typically battery-operated and easy to operate to facilitate the use in automated mode by people with very little training in the field, during transportation, and in emergency situations." + }, + { + "input": "Concept: Intellectual Property Rights (Document type)", + "output": "something described as the legal permission to use the work of an individual's original creation, such as trademarks, copyrights, patents, proprietary technologies and images." + }, + { + "input": "Concept: Manual Count (Research Techniques)", + "output": "Measurement described as a technique to determine the number of entities, which is performed by visual inspection." + }, + { + "input": "Concept: min.umol/L/(mg/g/d) (Quantitative Concept)", + "output": "Measurement Unit Description described as minutes times micromoles per liter (area under the curve), divided by milligrams per gram per day (daily dose normalized by body weight)." + }, + { + "input": "Concept: tartronate semialdehyde reductase (NADPH) activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)", + "output": "something described as catalysis of the reaction: (R)-glycerate + NADP+ = 2-hydroxy-3-oxopropanoate + NADPH + H+." + }, + { + "input": "Concept: mature teratoma (Neoplastic Process)", + "output": "something described as a type of benign (not cancer) germ cell tumor (type of tumor that begins in the cells that give rise to sperm or eggs) that often contains several different types of tissue such as hair, muscle, and bone." + }, + { + "input": "Concept: MU (Arbitrary Unit of Substance Content)", + "output": "Unit of Measure described as a quantity equivalent to the one thousandth unit (10E-3 unit)." + }, + { + "input": "Concept: Radiating pain in a dermatome (Sign or Symptom)", + "output": "Pain Perception described as unpleasant sensation indicating potential or actual damage to some body structure located in areas of skin served by the same nerve root." + }, + { + "input": "Concept: TNF-related apoptosis-inducing ligand (Biologically Active Substance)", + "output": "Biologically Active Substance described as tumor necrosis factor ligand superfamily member 10 (281 aa, ~33 kDa) is encoded by the human TNFSF10 gene. This protein plays a role in the induction of apoptosis." + }, + { + "input": "Concept: Malformation of facial skeleton (Anatomical Abnormality)", + "output": "Abnormal skull morphology described as an abnormality of one or more of the set of bones that make up the facial skeleton." + }, + { + "input": "Concept: intermediate filament polymerization or depolymerization (protein-containing complex subunit organization)", + "output": "Cell Function described as assembly or disassembly of intermediate filaments by the addition or removal of component parts from a filament." + }, + { + "input": "Concept: Gastric Neuroendocrine Tumor pT3 TNM Finding v7 (Finding)", + "output": "Gastric Neuroendocrine Tumor Pathologic Primary Tumor TNM Finding v7 described as gastric neuroendocrine tumor penetrating subserosa." + }, + { + "input": "Concept: MISMATCH REPAIR GENE PMSL1 (DNA Repair Gene)", + "output": "Gene or Genome described as this gene is involved in mismatch repair and mutations in the gene result in hereditary non-polyposis colon cancer 3." + }, + { + "input": "Concept: BEAT GBR 1342 (Bispecific Monoclonal Antibodies)", + "output": "Amino Acid, Peptide, or Protein described as a humanized, bispecific monoclonal antibody (BsAb) against human CD3, a T-cell surface antigen, and the human cell surface glycoprotein CD38, a tumor-associated antigen (TAA), with potential antineoplastic activity. Upon administration, anti-CD38/anti-CD3 bispecific monoclonal antibody GBR 1342 binds to both CD3 on T cells and CD38 expressed on certain tumor cells. This results in the cross-linking of T cells and tumor cells, and induces a potent cytotoxic T-lymphocyte (CTL) response against CD38-expressing tumor cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies; its expression has been correlated with poor prognosis. GBR 1342 uses the proprietary bispecific engagement by antibodies based on the T-cell receptor (BEAT) platform." + }, + { + "input": "Concept: esophago (Anatomy Qualifier)", + "output": "something described as relating to esophagus" + }, + { + "input": "Concept: Proprioceptive hallucination (Finding)", + "output": "Finding described as perception of the orientation of the body in space, manifesting as a sensation of floating, flying, in the absence of a corresponding stimulus." + }, + { + "input": "Concept: Administration of drug or medicament via intravenous route (Administration of treatment via specific route)", + "output": "Introduction of therapeutic substance into vein described as preparing and giving medications via the intravenous route" + }, + { + "input": "Concept: Thyroid Cancer pNX TNM Finding (Thyroid Cancer Pathologic Regional Lymph Nodes TNM Finding v7)", + "output": "Thyroid Cancer Pathologic Regional Lymph Nodes TNM Finding v7 described as thyroid cancer in which regional lymph nodes cannot be assessed." + }, + { + "input": "Concept: RP2 wt Allele (Gene or Genome)", + "output": "RP2 gene described as human RP2 wild-type allele is located within Xp11.4-Xp11.21 and is approximately 45 kb in length. This allele, which encodes protein XRP2, plays a role in photoreceptor development. Mutations in this gene are associated with X-linked mental retardation with retinitis pigmentosa." + }, + { + "input": "Concept: measurement in general (Data Collection Methods)", + "output": "Techniques described as general heading term covering detection and quantification of phenomena, for terms not treed elsewhere under TECHNOLOGY/TECHNIQUE." + }, + { + "input": "Concept: Normal (Physical Exam Result)", + "output": "Physical Exam Result described as a clinical finding in which there are no abnormal findings on visual inspection of the abdomen." + }, + { + "input": "Concept: Intradural Extramedullary Tumor of Spinal Canal (Neoplastic Process)", + "output": "Intraspinal Neoplasm described as a neoplasm that occurs within the spinal canal in the space between the spinal cord and the dura mater. Representative examples include meningioma, neurofibroma, and sarcoma. Signs and symptoms include local and radicular pain, weakness and spinal cord compression." + }, + { + "input": "Concept: Rectal mucositis (Finding)", + "output": "something described as a disorder characterized by ulceration or inflammation of the mucous membrane of the rectum." + }, + { + "input": "Concept: Mid zone of circumflex branch of left coronary artery (Body Location or Region)", + "output": "something described as zone of circumflex branch of left coronary artery which supplies the mid inferior and inferolateral zones of myocardium of left ventricle." + }, + { + "input": "Concept: European Directorate for the Quality of Medicines and HealthCare Administration Device (Intellectual Product)", + "output": "something described as terminology subset about devices that are used to administer a pharmaceutical product." + }, + { + "input": "Concept: Emulsion for injection/infusion (Biomedical or Dental Material)", + "output": "Drug emulsion described as liquid sterile single-dose or multidose preparation consisting of an emulsion intended for administration by injection or infusion. Comment: The preparation is usually diluted before administration by infusion." + }, + { + "input": "Concept: TFG/ALK Fusion Gene (Fusion Gene)", + "output": "Gene or Genome described as a fusion gene that results from a chromosomal translocation t(2;3)(p23;q21) which fuses a portion of the 5' part of the TFG gene to the last 10 exons of the ALK gene. This rearrangement is associated with anaplastic large cell lymphoma." + }, + { + "input": "Concept: Polymerase, Taq (Enzyme)", + "output": "DNA-Directed DNA Polymerase described as a heat stable DNA-directed DNA polymerase. The enzyme is widely utilized in laboratory polymerase chain reaction applications." + }, + { + "input": "Concept: CBG - Corticosteroid binding globulin (Biologically Active Substance)", + "output": "Alpha-Globulins described as a serpin family member that binds to and transports GLUCOCORTICOIDS in the BLOOD." + }, + { + "input": "Concept: hemi-methylated DNA-binding (double-stranded DNA binding)", + "output": "something described as interacting selectively and non-covalently with double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks." + }, + { + "input": "Concept: 171 SALMONELLA (Bacterium)", + "output": "something described as a genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that utilizes citrate as a sole carbon source. It is pathogenic for humans, causing enteric fevers, gastroenteritis, and bacteremia. Food poisoning is the most common clinical manifestation. Organisms within this genus are separated on the basis of antigenic characteristics, sugar fermentation patterns, and bacteriophage susceptibility." + }, + { + "input": "Concept: Pathological process (Biological Processes)", + "output": "something described as a biologic function or a process having an abnormal or deleterious effect at the subcellular, cellular, multicellular, or organismal level." + }, + { + "input": "Concept: At high risk for Ebola haemorrhagic fever (Finding)", + "output": "At risk of infection described as someone who has been determined to be at high risk for developing EVD. This may include criteria such as CDC: 1) Percutaneous or mucous membrane exposure to blood or body fluids of an EVD patient; 2) Direct skin contact with, or exposure to blood or body fluids of, an EVD patient without appropriate personal protective equipment (PPE); 3) Processing blood or body fluids of a person with Ebola while the person was symptomatic without appropriate PPE or standard biosafety precautions; 4) Direct contact with a dead body without appropriate PPE in a country where an EVD outbreak is occurring; 5) Having lived in the immediate household and provided direct care to a person with Ebola while the person was symptomatic." + }, + { + "input": "Concept: multiple myelomatosis (stage, plasma cell neoplasm)", + "output": "Plasma Cell Neoplasm described as a bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia." + }, + { + "input": "Concept: Human egg (Germ Cells)", + "output": "Embryonic Structures described as a mature haploid female germ cell extruded from the OVARY at OVULATION." + }, + { + "input": "Concept: NPI1-Delusions Frequency (Intellectual Product)", + "output": "NPI Questionnaire Question described as neuropsychiatric Inventory - Frequency of the delusions." + }, + { + "input": "Concept: zeta Globin (Amino Acid, Peptide, or Protein)", + "output": "Biologically Active Substance described as a member of the alpha-globin family. In humans, zeta-globin is encoded in the alpha-globin gene cluster located on CHROMOSOME 16. Two zeta-globin chains combine with two EPSILON GLOBIN chains to form the embryonic HEMOGLOBIN Gower 1." + }, + { + "input": "Concept: positive regulation of dipeptide transmembrane transport (positive regulation of dipeptide transport)", + "output": "positive regulation of dipeptide transport described as any process that activates or increases the frequency, rate or extent of dipeptide transmembrane transport." + }, + { + "input": "Concept: bel (Quantitative Concept)", + "output": "Unit of Sound Intensity described as a logarithmic ratio unit (base-10 logarithms) used to express relative magnitude of a physical quantity (usually power or intensity) in comparison with a specified or implied reference level. Particularly, Bel is used as a unit of relative sound intensity. In the latter context it is equal to ten decibels or to approximately 1.151293 nepers." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Immunoassay, Therapeutic Drug, Cardiovascular, Nadolol (IVD Test Reagent/Kits, Immunoassay, Therapeutic Drug, Cardiovascular)", + "output": "IVD Test Reagent/Kits, Immunoassay, Therapeutic Drug, Cardiovascular described as immunoassay reagents intended to perform quantitative analyses on a body fluid sample (e.g., serum, plasma) to measure levels of nadolol (a non-selective beta-adrenergic antagonist used in cardiovascular disease to treat arrhythmias, angina pectoris, and hypertension, as well as migraine disorders and tremors) in the sample. Nadolol levels are seldom used in therapeutic drug monitoring as there is no close correlation between drug levels found in the blood and drug effects. These reagents are more typically used in the diagnosis of drug overdoses or drug-related toxicity." + }, + { + "input": "Concept: Drugs, Antiplatelet (Medicinal product categorized by therapeutic role)", + "output": "Hematologic Agents described as an agent that inhibits platelet aggregation and reduces coagulation in the circulatory system." + }, + { + "input": "Concept: High serine levels in cerebrospinal fluid (Abnormal CSF serine concentration)", + "output": "Abnormal CSF serine concentration described as abnormally increased levels of serine in cerebrospinal fluid." + }, + { + "input": "Concept: Interleukin 3 Precursor (Interleukins)", + "output": "Interleukins described as interleukin-3 (152 aa, ~17 kDa) is encoded by the human IL3 gene. This protein plays a role in neurotrophic activity and the proliferation of several types of hematopoietic lineage cells." + }, + { + "input": "Concept: iron import into cell by endocytosis (Cell Function)", + "output": "something described as uptake of iron into a cell via binding to an extracellular receptor, which is internalized by endocytosis." + }, + { + "input": "Concept: positive regulation of dauer larval development (positive regulation of nematode larval development)", + "output": "something described as any process that increases the rate, frequency, or extent of dauer larval development, the process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding." + }, + { + "input": "Concept: Nonspecific abnormal EMG (Abnormal muscle physiology)", + "output": "Abnormal finding on evaluation procedure described as abnormal results of investigations using electromyography (EMG)." + }, + { + "input": "Concept: L-tyrosine permease activity (aromatic amino acid transmembrane transporter activity)", + "output": "aromatic amino acid transmembrane transporter activity described as enables the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid." + }, + { + "input": "Concept: downregulation of ATP-dependent RNA helicase activity (Molecular Function)", + "output": "regulation of RNA helicase activity described as any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent RNA helicase activity." + }, + { + "input": "Concept: Pancreatic nerve plexus (Body Part, Organ, or Organ Component)", + "output": "Body Part, Organ, or Organ Component described as an autonomic plexus that is a subdivision of the celiac plexus and accompanies the pancreatic arteries" + }, + { + "input": "Concept: Smoothened Antagonist LDE225 Topical (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as a topical formulation of the small-molecule Smoothened (Smo) antagonist LDE225 with potential antineoplastic activity. Upon topical application, smoothened antagonist LDE225 selectively binds to the Hedgehog (Hh)-ligand cell surface receptor Smo, which may result in the suppression of the Hh signaling pathway and, so, the inhibition of tumor cells in which this pathway is abnormally activated. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair. Inappropriate activation of Hh pathway signaling and uncontrolled cellular proliferation, as is observed in a variety of cancers, may be associated with mutations in the Hh-ligand cell surface receptor Smo." + }, + { + "input": "Concept: Structure of piriform recess (Surface of anatomical cluster)", + "output": "something described as a pear-shaped fossa in the wall of the laryngeal pharynx lateral to the arytenoid cartilage and medial to the lamina of the thyroid cartilage." + }, + { + "input": "Concept: Hydrencephalus (Abnormality of the cerebral ventricles)", + "output": "Hydrocephalus described as an abnormal accumulation of cerebrospinal fluid within the ventricles of the brain." + }, + { + "input": "Concept: Adult Classic Hodgkin Lymphoma (Adult Hodgkin Lymphoma)", + "output": "Classical Hodgkin's Lymphoma described as classic Hodgkin lymphoma that occurs in adults." + }, + { + "input": "Concept: ReferenceResult.referenceTypeCode (Intellectual Product)", + "output": "something described as a coded value specifying the kind of reference, i.e. how it is to be used or what its purpose is. EXAMPLE(S): normal range limit of quantitation clinical concern range data checking range alert range OTHER NAME(S): NOTE(S):" + }, + { + "input": "Concept: RAND-36 - Time Physical Health or Emotional Problems Interfere With Social Activities (RAND-36 Questionnaire Question)", + "output": "Intellectual Product described as RAND 36-Item Health Survey 1.0 (RAND-36) During the past 4 weeks, how much of the time has your physical health or emotional problems interfered with your social activities?" + }, + { + "input": "Concept: GAP (Gene or Genome)", + "output": "something described as human RASA1 wild-type allele is located in the vicinity of 5q13.3 and is approximately 124 kb in length. This allele, which encodes Ras GTPase-activating protein 1, plays a role in the regulation of guanidine triphosphate hydrolysis. Mutation of the gene is associated with capillary malformation-arteriovenous malformation, Parkes Weber syndrome and basal cell carcinomas." + }, + { + "input": "Concept: Lymphangioma, no ICD-O subtype (Lymphatic Diseases)", + "output": "Benign neoplasm of lymph vessels described as a benign tumor resulting from a congenital malformation of the lymphatic system. Lymphangioendothelioma is a type of lymphangioma in which endothelial cells are the dominant component." + }, + { + "input": "Concept: Hovawart (Mammal)", + "output": "Working Breed described as a large, heavy-boned and kind, even-tempered dog with a very good nose. This breed excels at tracking, guarding, and companionship. The coat is long and black and blond with gold markings. The average height range is 23-28 inches and the average weight range is 65-90 pounds." + }, + { + "input": "Concept: Sagittal craniostenosis with congenital heart disease, mental deficiency and mandibular ankylosis (Hereditary Connective Tissue Disorder)", + "output": "Congenital anomaly of bone and joint described as multiple cardiocranial defects, including craniosynostosis, cardiovascular malformations, mandibular ankylosis, and other dysmorphic features occurring in various associations." + }, + { + "input": "Concept: Calcified Medical Device Material (Material Degradation)", + "output": "Material Degradation described as problem associated with buildup of calcium salts on a device." + }, + { + "input": "Concept: alcohol induced psychosis (Organic brain syndrome)", + "output": "something described as acute and chronic mental disorders characterized by gross impairment in reality perception due to alcoholism; evidenced by delusions, hallucinations, markedly incoherent speech or disorganized and agitated behavior; includes alcohol withdrawal seizures and delirium, alcohol amnestic disorder and alcoholic neuropathies." + }, + { + "input": "Concept: Agree slightly (Finding)", + "output": "something described as a response indicating that an individual is in slight agreement with something." + }, + { + "input": "Concept: spinal nucleus of the trigeminal, oral part, caudal dorsomedial part (Body Part, Organ, or Organ Component)", + "output": "Body Part, Organ, or Organ Component described as one of five subdivisions of the oral part of the spinal trigeminal nucleus in the rat ( Swanson-2004 )." + }, + { + "input": "Concept: Product containing ustekinumab (Monoclonal Antibodies)", + "output": "Monoclonal Antibodies described as an orally available, human, IgG1kappa, monoclonal antibody directed against the p40 protein subunit of both interleukin-12 (IL-12) and IL-23, with immunomodulating activity. Upon administration, ustekinumab binds to the p40 subunit of IL-12 and IL-23, blocking the binding of IL-12 and IL-23 to their interleukin receptors. This inhibits IL-12- and IL-23-mediated signaling and inhibits differentiation of CD4-positive T cells into Th1 and Th17 cells. This prevents Th1- and Th17-mediated responses and cytokine production. This may prevent graft versus host disease (GVHD). IL-12 and IL-23, cytokines that play a key role in the regulation of the immune system, are upregulated in immune-mediated inflammatory disorders. Both Th1 and Th17 cells play a crucial role in GVHD." + }, + { + "input": "Concept: Clonazepam-containing product (Anti-Anxiety Agents)", + "output": "Anti-Anxiety Agents described as 5-(o-chlorophenyl)-1,3-dihydro -7-nitro-2H-1,4-benzodiazepin-2-one; anticonvulsant used against epileptic seizures and tardive dyskinesia." + }, + { + "input": "Concept: Shotgun Sequence Assembly (DNA analysis)", + "output": "something described as the assembly of a complete stretch of DNA sequence from a set of sub-sequences whose order in the longer stretch is unknown. Requires the use of computerized sequence analyses to determine the correct order of fragments in order to assemble to entire stretch of DNA sequence." + }, + { + "input": "Concept: Schizophrenia and Disorders with Psychotic Features (Mental disorders)", + "output": "Mental or Behavioral Dysfunction described as marked disorders of thought (delusions, hallucinations, or other thought disorder accompanied by disordered affect or behavior), and deterioration from a previous level of functioning. Individuals have one o more of the following symptoms: delusions, hallucinations, and disorganized speech." + }, + { + "input": "Concept: LZM-009 (Anti-PD1 Monoclonal Antibody)", + "output": "Amino Acid, Peptide, or Protein described as a recombinant, humanized monoclonal antibody directed against the negative immunoregulatory human cell surface receptor, programmed cell death 1 (PD-1), with potential immune checkpoint inhibitory and antineoplastic activities. Upon intravenous administration, LZM009 binds to PD-1 and inhibits the binding of PD-1 to the PD-1 ligands, programmed cell death-1 ligand 1 (PD-L1) and PD-1 ligand 2 (PD-L2). This prevents the activation of PD-1 and its downstream signaling pathways, leading to the activation of both T cells and T-cell-mediated immune responses against tumor cells. PD-1 is a transmembrane protein in the immunoglobulin (Ig) superfamily expressed on activated T cells that negatively regulates T-cell activation and effector function when activated by its ligands. PD-1 plays an important role in tumor evasion from host immunity." + }, + { + "input": "Concept: Breast Carcinoma cN3 TNM Finding v8 (Finding)", + "output": "Finding described as breast cancer with metastases in ipsilateral infraclavicular (level III axillary) lymph node(s) with or without level I, II axillary lymph node involvement; or in ipsilateral internal mammary lymph node(s) with level I, II axillary lymph node metastases; or metastases in ipsilateral supraclavicular lymph node(s) with or without axillary or internal mammary lymph node involvement." + }, + { + "input": "Concept: ferric triacetylfusarinine C import into cell (siderophore-dependent iron import into cell)", + "output": "nitrogen compound transport described as the directed movement of ferric triacetylfusarinine C into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." + }, + { + "input": "Concept: IMN 1207 (Amino Acid, Peptide, or Protein)", + "output": "Anticachexia Agent described as a biologically active, cysteine-rich, undenatured, bovine whey-based protein isolate with potential anti-cachexia and glutathione-enhancing properties. Upon administration of cysteine-rich whey protein isolate, cystine and glutamylcystine are taken up by cells and release free cysteine. The available cysteine allows cells to synthesize glutathione (GSH), a tripeptide made from amino acids glycine, glutamate and cysteine, thereby maintaining and increasing intracellular GSH concentrations. GSH plays a major role as an antioxidant, thereby protecting cells from oxidative damage due to harmful substances such as free radicals and reactive oxygen compounds. As IMN 1207 is rich in protein, this agent may prevent weight loss and increase body weight and strength." + }, + { + "input": "Concept: Hypertension Severity (Symptom Status)", + "output": "something described as severity of signs and symptoms of chronic elevated blood pressure" + }, + { + "input": "Concept: negative regulation of protein K48-linked ubiquitination (Molecular Function)", + "output": "regulation of protein K48-linked ubiquitination described as any process that stops, prevents or reduces the frequency, rate or extent of K48-linked ubiquitination, a protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 48 of the ubiquitin monomers, is added to a protein. K48-linked ubiquitination targets the substrate protein for degradation." + }, + { + "input": "Concept: Marfan Syndrome Gene Deletion/Duplication Panel Reagents (Medical Device)", + "output": "Medical Device described as molecular assay reagents intended to identify deletions or duplications of genes associated with Marfan syndrome, a connective tissue disorder characterized by cardiovascular, eye, and skeletal abnormalities. Genetic variants at multiple loci have been associated Marfan syndrome. These reagents are intended to detect deletions and duplications in multiple Marfan syndrome-associated loci simultaneously." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Ehrlichia Species (Medical Device)", + "output": "something described as molecular assay reagents intended to identify species of Ehrlichia, a genus of bacteria of the family Rickettsiaceae, by detecting specific nucleic-acid information of the target bacteria. Some species of these bacteria are etiologic agents of monocytic ehrlichiosis in humans (i.e., they attack monocytes, a type of white blood cell)." + }, + { + "input": "Concept: Rescue Medications (Auxiliary Medicinal Product)", + "output": "something described as medicinal products identified in the protocol as those that may be administered to subjects when the efficacy of the Investigational Medicinal Product is not satisfactory, the effect of the IMP is too great and is likely to cause a hazard to the patient, or to manage an emergency situation. (EU-CTR Recommendations from the expert group on clinical trials for the implementation of Regulation (EU) No 536/2014' dd 28 June 2017)" + }, + { + "input": "Concept: Radiofrequency Therapy Systems, Hyperthermia, Superficial (Medical Device)", + "output": "Radiofrequency Therapy Systems, Hyperthermia described as hyperthermia radio-frequency (RF) therapy systems designed for localized heating of malignant tumors up to a few (e.g., three) centimeters deep. These systems consist of an RF generator (frequencies from 10 to 30 MHz are typical) connected either to two electrode plates (capacitive coupled systems) or to a coil (inductive coupled systems)." + }, + { + "input": "Concept: guanidine (Guanidines)", + "output": "Guanidine and guanidine derivative described as a strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC." + }, + { + "input": "Concept: aminoacetone:oxygen oxidoreductase(deaminating) activity (Molecular Function)", + "output": "something described as catalysis of the reaction: aminoacetone + H2O + O2 = methylglyoxal + NH3 + hydrogen peroxide + H+." + }, + { + "input": "Concept: diaminohydroxyphosphoribosylaminopyrimidine deaminase activity (deaminase activity)", + "output": "Molecular Function described as catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(2)O + H(+) = 5-amino-6-(5-phosphoribosylamino)uracil + NH(4)(+)." + }, + { + "input": "Concept: PAX3/FOXO1 Fusion Protein (Fusion protein)", + "output": "Fusion protein described as a fusion protein (836 aa, ~92 kDa) encoded by the PAX3/FOXO1 fusion gene. This protein is comprised of the N-terminal DNA binding domain of paired box protein Pax-3 and the C-terminal transactivation domain of forkhead box protein O1." + }, + { + "input": "Concept: Thoracic paravertebral ganglion (Structure of half of thorax lateral to midsagittal plane)", + "output": "Structure of thoracic portion of sympathetic nervous system described as any of the 11 or 12 pairs of paravertebral ganglia in the thoracic portion of the sympathetic trunk that house the nerve cell bodies for postganglionic sympathetic nerve fibers." + }, + { + "input": "Concept: MP0250 (Antineoplastic Protein Inhibitor)", + "output": "Antineoplastic Protein Inhibitor described as a designed ankyrin repeat proteins (DARPin)-based agent targeting vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), with potential antiangiogenic and antineoplastic activities. Compared to antibodies, DARPins are small in size, have favorable pharmacokinetics and allow for both high affinity binding and efficacy. Upon administration, the VEGF/HGF-targeting DARPin MP0250 binds to and inhibits both HGF and VEGF. This prevents HGF- and VEGF-mediated signaling, and inhibits the growth of HGF/VEGF-overexpressing tumor cells. This agent also prevents osteolysis, due to the inhibitory effect on HGF signaling. HGF and VEGF are overexpressed in a variety of cancer cell types and are associated with increased cell proliferation, migration and adhesion. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C117236\" active clinical trials using this agent." + }, + { + "input": "Concept: Benign Congenital Muscular Dystrophy (Myopathy)", + "output": "Hereditary progressive muscular dystrophy described as a benign autosomal dominant form of slowly progressive muscular dystrophy. To date, fewer than 100 cases have been reported in the literature, thus illustrating its rarity. The clinical features do not differ markedly from those of other mild forms of progressive muscular dystrophy with the exception of finger contractures that are sometimes suggestive of the diagnosis. Creatine kinase levels and histological findings are not conclusive. Mutations in one of the three subunits of collagen VI are responsible for the disease. Molecular studies are however hampered by the size and expression pattern of the genes. Treatment remains purely supportive." + }, + { + "input": "Concept: RETELLIPTINE (Topoisomerase II Inhibitors)", + "output": "Pharmacologic Substance described as an ellipticine derivative and topoisomerase II inhibitor with antineoplastic activity. Retelliptine intercalates with DNA and inhibits topoisomerase II during DNA replication. In addition, this agent appears to induce cell cycle arrest at G2/M phase and apoptosis mediated through the Fas/Fas ligand death receptor and the mitochondrial pathway." + }, + { + "input": "Concept: regulation of poly(A)-specific ribonuclease activity (Genetic Function)", + "output": "Genetic Function described as any process that modulates the rate, frequency or extent of the catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." + }, + { + "input": "Concept: Chronic decreased circulating IgD (Decreased circulating IgD)", + "output": "Decreased circulating IgD described as a lasting reduction beneath the normal level of total immunoglobulin D (IgD) in the blood. []" + }, + { + "input": "Concept: CHD1 (Gene or Genome)", + "output": "Helicase Gene described as this gene is involved in the modification of chromatin structure." + }, + { + "input": "Concept: Stage IS Testicular Cancer AJCC v7 (Stage I Testicular Cancer AJCC v6 and v7)", + "output": "Neoplastic Process described as stage IS includes: Any pT/TX, N0, M0, S1-3. pTX: Primary tumor cannot be assessed. N0: No regional lymph node metastasis. M0: No distant metastasis. S1: LDH less than 1.5 x N (N indicates the upper limit of normal for the LDH assay) and hCG less than 5,000 and AFP less than 1,000. S2: LDH 1.5-10 x N or hCG 5,000-50,000 or AFP 1,000-10,000. S3: LDH more than 10 x N or hCG more than 50,000 or AFP more than 10,000." + }, + { + "input": "Concept: Interferon-Induced, Hepatitis C-Associated Microtubular Aggregate Protein, 44kD Gene (IFI44 gene)", + "output": "something described as human IFI44 wild-type allele is located in the vicinity of 1p31.1 and is approximately 14 kb in length. This allele, which encodes interferon-induced protein 44, may be involved in interferon-mediated viral responses." + }, + { + "input": "Concept: fractalkine receptor binding (chemokine receptor binding)", + "output": "chemokine receptor binding described as interacting selectively and non-covalently with a CX3C chemokine receptor." + }, + { + "input": "Concept: 6: 151653623-151770023 (Spatial Concept)", + "output": "Chromosome 6 Physical Location described as physical location of AKAP12_Gene" + }, + { + "input": "Concept: area 12r of Carmichael (Body Location or Region)", + "output": "something described as a portion of the orbital gyri that is defined on the basis of internal structure in the macaque. It is one of four components of area 12 (macaque) in the orbitomedial prefrontal cortex. The other components are area 12m (macaque), area 12o (macaque), and area 12l (macaque) ( Carmichael-1994 ). Some authors divide area 12 (macaque) into only two parts, an orbital part and a lateral part ( Paxinos-2009a ).\\r\\nIts human equivalent is area 47/12r ( Ongur-2003 ). As granular prefrontal cortex, it has no equivalent in the rat ( Wallis-2012 )." + }, + { + "input": "Concept: MMS101E (MMSE Functional Test Question)", + "output": "MMSE Functional Test Question described as mini-Mental State Examination - What is the date?" + }, + { + "input": "Concept: WHYTE SYNDROME (Spondyloepimetaphyseal disorder)", + "output": "something described as a rare primary bone dysplasia disorder with characteristics of congenital hypotrichosis associated with rhizomelic short stature (more pronounced in upper limbs than lower limbs), limited hip abduction and mild genu varum. Flared and irregular metaphyses, delayed and irregular epiphyseal ossification and pear-shaped vertebral bodies are characteristic radiologic findings." + }, + { + "input": "Concept: jarring (Devices)", + "output": "Healthcare facility device and adaptation described as container, without a pronounced neck, with a wide opening at the top and a more-or-less flat bottom. It is suited for semi-solid and solid pharmaceutical forms (including those that are stored/supplied in a liquid medium, such as living tissue equivalents). It can be reclosed." + }, + { + "input": "Concept: kidney; atrophy (Renal structural abnormalities and trauma)", + "output": "Disease or Syndrome described as atrophy of the kidney." + }, + { + "input": "Concept: Vena iliolumbalis (Structure of tributary of common iliac vein)", + "output": "something described as a blood vessel running parallel to the iliolumbar artery connected to the deep circumflex iliac and lumbar veins that drains into the internal iliac vein." + }, + { + "input": "Concept: Chonemorpha G.Don, 1837 (Plant)", + "output": "Chonemorphinae described as a plant genus of the family APOCYNACEAE. It contains chonemorphine, a steroidal alkaloid." + }, + { + "input": "Concept: BBS Gene Mutation Panel Reagents (Medical Device)", + "output": "Medical Device described as molecular assay reagents intended to identify mutations in genes associated with Bardet-Biedl syndrome, a multisystem disorder characterized by vision loss, obesity, and additional signs and symptoms affecting other parts of the body. Genetic variants at multiple loci have been associated with Bardet-Biedl syndrome. These reagents are intended to detect mutations in multiple Bardet-Biedl syndrome-associated loci simultaneously." + }, + { + "input": "Concept: LA Grade D (Intellectual Product)", + "output": "Intellectual Product described as mucosal breaks which involve at least 75% of the esophageal circumference." + }, + { + "input": "Concept: Risk for venous thromboembolism (Physical injury)", + "output": "something described as susceptible to the development of a blood clot in a deep vein, commonly in the thigh, calf or upper extremity, which can break off and lodge in another vessel, which may compromise health." + }, + { + "input": "Concept: PerformedClinicalInterpretation (Research Activity)", + "output": "Performed Clinical Study Activity described as an assessment which involves determining the meaning of one or more other observation results. EXAMPLE(S): The results of a white blood cell count may be interpreted as constituting a grade 2 toxicity. OTHER NAME(S): NOTE(S):" + }, + { + "input": "Concept: CDISC Questionnaire EORTC QLQ-C30 Version 3 Test Code Terminology (Intellectual Product)", + "output": "CDISC Questionnaire Terminology described as test codes of questionnaire questions associated with the European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire - Core 30 Version 3.0 (EORTC QLQ-C30 Version 3) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: distal hereditary motor neuropathy type 7 (Autosomal dominant hereditary disorder)", + "output": "Chronic disease of respiratory system described as a rare slowly progressive genetic peripheral neuropathy with characteristics of distal atrophy and weakness affecting the upper limbs (with a predilection for the thenar eminence) and subsequently the lower limbs, associated with unilateral or bilateral vocal cord paresis leading to hoarse voice, breathing difficulties and facial weakness." + }, + { + "input": "Concept: FAC018-I Have Trouble Sleeping at Night (FACT-LYM Version 4 Questionnaire Question)", + "output": "Intellectual Product described as functional Assessment of Cancer Therapy-Lymphoma Version 4 - Additional Concerns: I have trouble sleeping at night." + }, + { + "input": "Concept: Manual Pheresis (Apheresis)", + "output": "Therapeutic or Preventive Procedure described as procedures such as plasmapheresis, plateletpheresis, and leukapheresis, in which unneeded portions of the whole blood are returned to the donor." + }, + { + "input": "Concept: Bronchoscopic Aspirating Tubes (Medical Device)", + "output": "Medical Device described as a bronchoscope (flexible or rigid) and accessories is a tubular endoscopic device with any of a group of accessory devices which attach to the bronchoscope and is intended to examine or treat the larynx and tracheobronchial tree. It is typically used with a fiberoptic light source and carrier to provide illumination. The device is made of materials such as stainless steel or flexible plastic. This generic type of device includes the rigid ventilating bronchoscope, rigid nonventilating bronchoscope, nonrigid bronchoscope, laryngeal-bronchial telescope, flexible foreign body claw, bronchoscope tubing, flexible biopsy forceps, rigid biopsy curette, flexible biopsy brush, rigid biopsy forceps, flexible biopsy curette, and rigid bronchoscope aspirating tube, but excludes the fiberoptic light source and carrier." + }, + { + "input": "Concept: Unknown If Ever Smoked (Finding)", + "output": "History of tobacco use described as indicates that a person's smoking status is unknown." + }, + { + "input": "Concept: Sociobiology (biology)", + "output": "Occupation or Discipline described as a branch of biology that attempts to explain animal behavior and social structures in terms of evolutionary advantage or strategy. It uses techniques from ethology, evolution and population genetics." + }, + { + "input": "Concept: Himalaya ProSelect(TM) Mentat JR 120 (Clinical Drug)", + "output": "Clinical Drug described as himalaya ProSelect(TM) Mentat JR 120, 490 mg tablets. UPC Code 605069106214." + }, + { + "input": "Concept: cellular response to mineralocorticoid stimulus (Cell Function)", + "output": "response to mineralocorticoid described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance." + }, + { + "input": "Concept: telomerase RNA localization to Cajal body (RNA localization to Cajal body)", + "output": "something described as a process in which telomerase RNA (TERC) is transported to, or maintained in, a Cajal body." + }, + { + "input": "Concept: Stents, Tracheal, Metallic, Self-Expanding (Stents, Tracheal, Metallic)", + "output": "Medical Device described as metallic tracheal stents that expand by themselves after deployment, applying a constant radial pressure to the tracheal walls. These devices consist either of compressed metallic stents that open by themselves as soon as they are released or of shape-memory stents manufactured from an alloy combining nickel and titanium (i.e., nitinol) that expands in response to body temperature. Some stents include radiopaque markers for accurate stent positioning. Self-expandable tracheal stents are typically deployed under local anesthetics using flexible bronchoscopes; they are mostly used to treat stenosis caused by injuries, benign diseases, or malignant tumors" + }, + { + "input": "Concept: DNA Synthesis Induction (DNA Replication)", + "output": "DNA Replication described as DNA Synthesis Induction consists of the initiation of activities involved in the polymeric linkage of deoxyribose moieties (with adenine, guanine, cytosine, or thymine side chains) by phosphate groups attached to their 5-prime and 3-prime sugar hydroxyls." + }, + { + "input": "Concept: Mouthpiece (Medical Device)", + "output": "something described as aid used for the administration or inhalation of a medicinal product by mouth." + }, + { + "input": "Concept: PRESS, VEIN (Medical Device)", + "output": "Medical Device described as an ear, nose, and throat manual surgical instrument is one of a variety of devices intended for use in surgical procedures to examine or treat the bronchus, esophagus, trachea, larynx, pharynx, nasal and paranasal sinus, or ear. This generic type of device includes the esophageal dilator; tracheal bistour (a long, narrow surgical knife); tracheal dilator; tracheal hook; laryngeal injection set; laryngeal knife; laryngeal saw; laryngeal trocar; laryngectomy tube; adenoid curette; adenotome; metal tongue depressor; mouth gag; oral screw; salpingeal curette; tonsillectome; tonsil guillotine; tonsil screw; tonsil snare; tonsil suction tub; tonsil suturing hook; antom reforator; ethmoid curette; frontal sinus-rasp; nasal curette; nasal rasp; nasal rongeur; nasal saw; nasal scissors; nasal snare; sinus irrigator; sinus trephine; ear curette; ear excavator; ear rasp; ear scissor, ear snare; ear spoon; ear suction tub; malleous ripper; mastoid gauge; microsurgical ear chisel; myringotomy tube inserter; ossici holding clamp; sacculotomy tack inserter; vein press; wire ear loop; microrule; mirror; mobilizer; ear, nose, and throat punch; ear, nose and throat knife; and ear, nose, and throat trocar." + }, + { + "input": "Concept: Stage IIIA Lung Adenosquamous Carcinoma AJCC v7 (Neoplastic Process)", + "output": "Neoplastic Process described as stage IIIA includes: (T1a, N2, M0); (T1b, N2, M0); (T2a, N2, M0); (T2b, N2, M0); (T3, N1, M0); (T3, N2, M0); (T4, N0, M0); (T4, N1, M0). T4: Lung cancer with a tumor of any size that invades any of the following: mediastinum, heart, great vessels, trachea, recurrent laryngeal nerve, esophagus, vertebral body, carina, and separate tumor nodule(s) in a different ipsilateral lobe. N1: Lung cancer with metastasis in ipsilateral peribronchial and/or ipsilateral hilar lymph nodes and intrapulmonary lymph nodes, including involvement by direct extension. N2: Lung cancer with metastasis to ipsilateral mediastinal and/or subcarinal lymph nodes. M0: No distant metastasis." + }, + { + "input": "Concept: interleukin 21 (Interleukin Gene)", + "output": "something described as this gene plays a role in both cytokine signaling and immune responses." + }, + { + "input": "Concept: liver cell differentiation (epithelial cell differentiation)", + "output": "Cell Function described as the process in which a relatively unspecialized cell acquires the specialized features of a hepatocyte. A hepatocyte is specialized epithelial cell that is organized into interconnected plates called lobules, and is the main structural component of the liver." + }, + { + "input": "Concept: Polyanhydroglucuronic Acid (Dietary Fiber)", + "output": "Cellulose and cellulose derivative described as a polysaccharide with glucose units linked as in CELLOBIOSE. It is the chief constituent of plant fibers, cotton being the purest natural form of the substance. As a raw material, it forms the basis for many derivatives used in chromatography, ion exchange materials, explosives manufacturing, and pharmaceutical preparations." + }, + { + "input": "Concept: upregulation of two-component signal transduction (Molecular Function)", + "output": "regulation of phosphorelay signal transduction system described as any process that activates or increases the frequency, rate or extent of signal transduction via a phosphorelay signal transduction system." + }, + { + "input": "Concept: Esophagus and Esophagogastric Junction Cancer (Squamous Cell Carcinoma and Adenocarcinoma) pN2 TNM Finding v8 (Finding)", + "output": "something described as esophagus and esophagogastric junction cancer with metastasis in three to six regional lymph nodes." + }, + { + "input": "Concept: Cardiomyopathy (Family history of cardiac disorder)", + "output": "Family history of cardiac disorder described as a history of a first-degree relative that was diagnosed with cardiomyopathy." + }, + { + "input": "Concept: Hyperplasia (Disease)", + "output": "Trophic disorders described as an increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells." + }, + { + "input": "Concept: VERTICILLIUM (Form family Moniliaceae)", + "output": "something described as a mitosporic fungal genus commonly isolated from soil. Some species are the cause of wilt diseases in many different plants." + }, + { + "input": "Concept: Bothered by Fever (Intellectual Product)", + "output": "Findings-Based Question described as a question about whether an individual is or was bothered by fevers." + }, + { + "input": "Concept: Specimen Collection Protocol (Process Protocol)", + "output": "Process Protocol described as the rule which guides how a specimen collection should be performed." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Serology, Bacteria, Legionella Species, IgG Antibody (IVD Test Reagent/Kits, Serology, Bacteria, Legionella Species, Antibody)", + "output": "IVD Test Reagent/Kits, Serology, Bacteria, Legionella Species, Antibody described as serology reagents intended to detect immunoglobulin G (IgG) antibodies to species of Legionella bacteria. These bacteria cause a pneumonia-like disease in humans (legionellosis)." + }, + { + "input": "Concept: Opiate Measurement (Opioid screening)", + "output": "something described as a measurement of any opiate class drug present in a biological specimen." + }, + { + "input": "Concept: LSD-1 Inhibitor IMG-7289 (Pharmacologic Substance)", + "output": "something described as an orally available, irreversible inhibitor of lysine-specific demethylase 1 (LSD1), with potential antineoplastic activity. Upon administration, IMG-7289 binds to and inhibits LSD1, a demethylase that suppresses the expression of target genes by converting the di- and mono-methylated forms of lysine at position 4 of histone H3 (H3K4) to mono- and unmethylated H3K4. LSD1 inhibition enhances H3K4 methylation and increases the expression of tumor suppressor genes. In addition, LSD1 demethylates mono- or di-methylated H3K9 which increases gene expression of tumor promoting genes; thus, inhibition of LSD1 also promotes H3K9 methylation and decreases transcription of these genes. Altogether, this may lead to an inhibition of cell growth in LSD1-overexpressing tumor cells. LSD1, an enzyme belonging to the flavin adenine dinucleotide (FAD)-dependent amine oxidase family is overexpressed in certain tumor cells and plays a key role in the regulation of gene expression, tumor cell growth and survival." + }, + { + "input": "Concept: amino levulinic acid (Amino Acids)", + "output": "Amino Acid, Peptide, or Protein described as a compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS." + }, + { + "input": "Concept: prostanoid formation (unsaturated fatty acid biosynthetic process)", + "output": "something described as the chemical reactions and pathways resulting in the formation of prostanoids, any compound based on or derived from the prostanoate structure." + }, + { + "input": "Concept: raffinose (R [Preparations])", + "output": "Trisaccharides described as a trisaccharide occurring in Australian manna (from Eucalyptus spp, Myrtaceae) and in cottonseed meal." + }, + { + "input": "Concept: Self-directed care behavior (Health behavior outcomes)", + "output": "Health behavior outcomes described as care recipient actions taken to direct others who assist with or perform physical tasks and personal health care" + }, + { + "input": "Concept: Public economic entitlements (Economic self-sufficiency)", + "output": "Activity described as having command over public economic resources, in order to ensure economic security for present and future needs." + }, + { + "input": "Concept: molecular orbital (quantum chemistry)", + "output": "something described as quantum mechanical paradigm for viewing electronic structure of molecules and their component atoms based on the overall molecular arrangement of nuclei." + }, + { + "input": "Concept: CDRS-R - Sleep Disturbance Comment (Intellectual Product)", + "output": "Intellectual Product described as children's Depression Rating Scale, Revised - Sleep disturbance comment." + }, + { + "input": "Concept: intralobar fissures (Body Space or Junction)", + "output": "Body Space or Junction described as sulci in the cerebral cortex that are located entirely within lobes ( Crosby-1962 )." + }, + { + "input": "Concept: Oxygen Monitors, Transcutaneous (Medical Device)", + "output": "something described as bedside monitors designed to continuously measure the partial pressure of carbon dioxide (tcpCO2), oxygen (tcpO2), or both at the skin surface. These monitors may use either two separate sensors or one combined tcPO2/tcPCO2 sensor that consist of a modified pH electrode, a single O2 cathode and heated reference electrode, a membrane, and an electrolyte enclosed in a shielded container; some monitors include a third sensor to measure the pH in the blood. Monitoring tcPO2 and tcPCO2 is useful to avoid hyperoxemia and hypoxemia, to assess surgical patients, and for continuous evaluation of the respiratory and metabolic status of patients." + }, + { + "input": "Concept: Anti-Neutrophil Cytoplasmic Antibody Measurement (Immunologic Tests)", + "output": "Immunologic Tests described as the determination of the anti-neutrophil cytoplasmic antibody present in a sample." + }, + { + "input": "Concept: prunus spinosa/blk thorn (Homeopathic remedies letter P)", + "output": "Homeopathic remedies letter P described as black thorn." + }, + { + "input": "Concept: aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) (Oxidoreductase Gene)", + "output": "Oxidoreductase Gene described as this gene is involved in the metabolism of aldehydes and ketones." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, CHM (Medical Device)", + "output": "something described as molecular assay reagents intended to identify mutations in the choroideremia (CHM) gene, located at chromosome Xq21.2, which encodes for the Rab escort protein-1 (REP1) that is involved in membrane trafficking. Mutations at this locus have been identified in most patients with choroideremia (X-linked blindness) and other hereditary eye diseases." + }, + { + "input": "Concept: Dung (Body Excretions)", + "output": "Gastrointestinal Fluid or Secretion described as the material discharged from the bowel during defecation. It consists of undigested food, intestinal mucus, epithelial cells, and bacteria." + }, + { + "input": "Concept: up regulation of smooth muscle hypertrophy (positive regulation of muscle adaptation)", + "output": "regulation of smooth muscle hypertrophy described as any process that activates or increases the frequency, rate or extent of smooth muscle hypertrophy." + }, + { + "input": "Concept: Structure of amnion (PLACENTA AND MEMBRANES)", + "output": "Embryonic Structures described as extraembryonic membrane which contains the embryo and amniotic fluid." + }, + { + "input": "Concept: Monoclonal Antibody hB72.3 (Immunologic Factor)", + "output": "something described as a humanized monoclonal antibody directed against tumor-associated glycoprotein 72 (TAG72). TAG72 is expressed in gastric, breast, pancreatic, colorectal, and ovarian carcinomas." + }, + { + "input": "Concept: Intracranial Leptomeningeal Lesion (Lesion)", + "output": "Finding described as a non-neoplastic or neoplastic pathologic process affecting the leptomeninges of the brain." + }, + { + "input": "Concept: negative regulation of GTP cyclohydrolase I activity (regulation of GTP cyclohydrolase I activity)", + "output": "Molecular Function described as any process that stops or reduces the activity of the enzyme GTP cyclohydrolase I." + }, + { + "input": "Concept: up regulation of protein kinase D signal transduction (Molecular Function)", + "output": "something described as any process that activates or increases the frequency, rate or extent of protein kinase D signaling." + }, + { + "input": "Concept: mRNA cap binding complex binding (Molecular Function)", + "output": "Molecular Function described as interacting selectively and non-covalently with a mRNA cap binding complex." + }, + { + "input": "Concept: pantetheine kinase (Molecular Function)", + "output": "Molecular Function described as catalysis of the reaction: ATP + pantetheine = ADP + pantetheine 4'-phosphate." + }, + { + "input": "Concept: B-Lymphocyte Antigen CD19, human (Adaptor Proteins, Signal Transducing)", + "output": "something described as b-lymphocyte antigen CD19 (556 aa, ~61 kDa) is encoded by the human CD19 gene. This protein is involved in enhancing B-cell receptor-dependent signaling." + }, + { + "input": "Concept: regulation of smooth muscle contraction involved in micturition (Organ or Tissue Function)", + "output": "Organ or Tissue Function described as any process that modulates the frequency, rate or extent of smooth muscle contraction involved in micturition." + }, + { + "input": "Concept: Calcium Phospholipid Dependent Protein Kinase (Protein or Riboprotein Complex)", + "output": "something described as nonEC." + }, + { + "input": "Concept: cell surface adhesin-mediated gliding motility (cell gliding)", + "output": "something described as cell gliding that results from the actions of cell surface adhesin proteins that are propelled by membrane motor proteins." + }, + { + "input": "Concept: Abnormality of the mitral valve (Anatomical Abnormality)", + "output": "Anatomical Abnormality described as any structural anomaly of the mitral valve." + }, + { + "input": "Concept: Celiac Disease Gene Mutation Panel Detection Reagents (Medical Device)", + "output": "something described as molecular assay reagents intended to identify mutations in genes associated with celiac disease, an autoimmune disorder in which the ingestion of gluten leads to damage to the small intestine. Genetic variants at multiple loci have been associated with various forms of celiac disease. These reagents are intended to detect mutations in multiple celiac disease-associated loci simultaneously." + }, + { + "input": "Concept: Free from injury related to perioperative positioning (Finding)", + "output": "Finding described as the patient is free from objective (e.g., reddened skin, bruising) and subjective (e.g., pain, discomfort) indicators of injury due to a misalignment of the patients body where there has been pressure, friction, shearing, and a decrease in circulation that causes nerve or tissue damage." + }, + { + "input": "Concept: FIGO Stage IA1 (Intellectual Product)", + "output": "something described as a FIGO stage term that applies to gynecologic cancers. For cervical cancer, it refers to invasive cancer that is diagnosed microscopically only. The stromal invasion has a maximum depth of 3.00 mm and a horizontal spread of 7.00 mm or less; there is no FIGO stage IA1 for endometrial cancer." + }, + { + "input": "Concept: occlusion by symbiont of host xylem (occlusion by symbiont of host vascular system)", + "output": "occlusion by symbiont of host vascular system described as the process in which an organism reduces the flow of fluid within the host xylem, the tissue in plants that carries water and nutrients up from the roots to the shoot and leaves. The host is defined as the larger of the organisms involved in a symbiotic interaction." + }, + { + "input": "Concept: 5-Pyrimidinecarboxamide, 2-Amino-N-(2,3-dihydro-7-methoxy-8-(3-(4-morpholinyl)propoxy)imidazo(1,2-C)quinazolin-5-yl)-, Hydrochloride (Organic Chemical)", + "output": "something described as the dihydrochloride salt form of copanlisib, a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Copanlisib hydrochloride inhibits the activation of the PI3K signaling pathway, which may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C138994\" active clinical trials using this agent." + }, + { + "input": "Concept: Patches (SolidDrugForm)", + "output": "Solid Dose Form described as a drug delivery system that often contains an adhesive backing that is usually applied to an external site on the body. Its ingredients either passively diffuse from, or are actively transported from, some portion of the patch. Depending upon the patch, the ingredients are either delivered to the outer surface of the body or into the body. A patch is sometimes synonymous with the terms Extended Release Film and System." + }, + { + "input": "Concept: Robot-assisted Salvage Pelvic Mass Resection (Salvage Surgery)", + "output": "Therapeutic or Preventive Procedure described as a surgical technique that uses a specially designed robotic system to aid removal of a pelvic mass after failure of initial surgery or other treatment modalities." + }, + { + "input": "Concept: cell chemotaxis to vascular endothelial growth factor (Cell Function)", + "output": "Cell Function described as the directed movement of a motile cell in response to the presence of vascular endothelial growth factor (VEGF)." + }, + { + "input": "Concept: Status, Nutrition (Impaired mobility: physiological status)", + "output": "Nutrition Phenomena described as the state of the body as influenced by the diet and the ability of the diet to maintain an overall healthy condition." + }, + { + "input": "Concept: 1/mL (Unit of Number Concentration)", + "output": "something described as a unit of measurement equal to 10 to the third power of entities per unit of volume equal to one liter." + }, + { + "input": "Concept: Congenital, familial and genetic disorders (Classification)", + "output": "Classification described as this SMQ is a sub-search of SMQ Pregnancy and neonatal topics. For detailed description, please refer to the one in SMQ Pregnancy and neonatal topics." + }, + { + "input": "Concept: Visual agnosia (Specific cognitive ability disturbances)", + "output": "Psychophysical visual disturbance described as an inability to recognize or interpret objects by sight." + }, + { + "input": "Concept: Ovarian Endometrioid Tumor (Endometrioid tumor)", + "output": "Neoplastic Process described as a benign, borderline, or malignant epithelial tumor of the ovary characterized by the presence of glands and/or cysts lined by neoplastic cells that resemble endometrial cells." + }, + { + "input": "Concept: Structured Product Labeling Licensing Terminology (Intellectual Product)", + "output": "something described as terminology used to indicate the authorization of a business to perform specific duties or functions." + }, + { + "input": "Concept: Analyzers, Physiologic, Cardiovascular Function, Central Blood Pressure (Analyzers, Physiologic, Cardiovascular Function)", + "output": "Analyzers, Physiologic, Cardiovascular Function described as physiologic analyzers designed for non-invasive assessment of the main characteristics of the cardiovascular function and the blood central circulatory system based on the variations of the blood pressure waveform. These analyzers usually consist of a computerized unit that includes as components a calibrated tonometer to measure the blood pressure and an electrocardiograph, both with appropriate probes and leads, and also dedicated software. The equipment usually measure the blood pressure on an artery (e.g., radial), the pulse wave velocity between two arteries, and electrocardiography parameters such as heart rate. The analyzer asses some of the main parameters that determine the heart and vasculature status, such as ejection index and aortic blood pressure; the pressure on other arteries such as the brain and kidney may be also assessed. Conditions such as the cardiac function status, heart rate variability, and vascular elasticity (i.e., artery stiffness) are also assessed helping in the evaluation of risks for cardiac diseases and the evaluation of drug effects." + }, + { + "input": "Concept: Thymic Tumor cM1 TNM Finding v8 (Finding)", + "output": "something described as thymic tumor with pleural, pericardial, or distant metastasis." + }, + { + "input": "Concept: Product containing silodosin (Pharmacologic Substance)", + "output": "Organic Chemical described as an orally available, alpha-1 adrenoreceptor (alpha-1a) selective antagonist that can be used to relieve symptoms of benign prostate hyperplasia (BPH). Upon administration, silodosin selectively binds alpha-1a receptors located in the human prostate and bladder with high affinity and blocks signaling pathways mediated by alpha-1a. Blockade of these receptors causes smooth muscle relaxation, lowers intraurethral pressure, and results in improved urine flow and a reduction in the symptoms of BPH, such as difficulty with urinating, painful urination, urinary frequency and incomplete bladder emptying. In addition, silodosin may be used to improve lower urinary tract symptoms, which can occur after receiving radiation therapy for prostate cancer." + }, + { + "input": "Concept: PDGFA wt Allele (Gene or Genome)", + "output": "Gene or Genome described as human PDGFA wild-type allele is located within 7p22 and is approximately 22 kb in length. This allele, which encodes platelet-derived growth factor subunit A protein, plays a role in mitogenesis for mesenchymal cells." + }, + { + "input": "Concept: PlannedRepeatActivityUntilRule.cessationPauseQuantityRange (Quantitative Concept)", + "output": "Quantitative Concept described as a quantity of time falling within minimum and maximum bounds that specifies the elapsed time after the observed result occurs and before the cessation of repeating the activity. EXAMPLE(S): Stop 20 days after the observed event occurs. OTHER NAME(S): NOTE(S):" + }, + { + "input": "Concept: RAND-36 - Feel Worn Out (Intellectual Product)", + "output": "RAND-36 Questionnaire Question described as RAND 36-Item Health Survey 1.0 - How much of the time during the past 4 weeks: Did you feel worn out?" + }, + { + "input": "Concept: Aftereffect (Pathologic Function)", + "output": "Pathologic Function described as any symptom or condition which is a result of a medical intervention but arises months or years after it." + }, + { + "input": "Concept: hCG 1778014 (PXN gene)", + "output": "PXN gene described as human PXN wild-type allele is located in the vicinity of 12q24.31 and is approximately 55 kb in length. This allele, which encodes paxillin protein, is involved in focal adhesions, cytoskeletal structure and integrin-mediated signaling." + }, + { + "input": "Concept: Dental Materials, Cavity Varnish (Dental Materials)", + "output": "something described as cavity lining dental solutions designed for use as a very thin protective coating over the surfaces of a dental cavity before placement of restorative materials. These dental materials consist of clear solutions of a resinous material or natural gum in a suitable organic solvent (e.g., ether or chloroform), that quickly evaporate and leave the resin as a very thin film over the preparation. Cavity varnish is not intended for use with composite resins since the varnish retards their set and interferes with their bonding. They are used in dentists' offices during operative dental procedures primarily to seal the dentinal tubules and to help prevent seepage of fluids, microorganisms, and/or debris between a restoration and the cavity walls (i.e., microleakage)." + }, + { + "input": "Concept: Mitochondrial Matrix Protein P1 (Amino Acid, Peptide, or Protein)", + "output": "something described as 60 kDa heat shock protein, mitochondrial (573 aa, ~61 kDa) is encoded by the human HSPD1 gene. This protein plays a role in mitochondrial protein folding." + }, + { + "input": "Concept: Duck hepatitis B virus DHBV (Hepadnaviridae)", + "output": "Virus described as a DNA virus that closely resembles human hepatitis B virus. It has been recovered from naturally infected ducks." + }, + { + "input": "Concept: FGF20 (Fibroblast Growth Factor Gene Family)", + "output": "something described as this gene plays a role in development, cell growth, morphogenesis and tissue repair." + }, + { + "input": "Concept: intracellular iron ion storage (Cell Function)", + "output": "sequestering of iron ion described as the process of binding or confining iron ions in an intracellular area such that they are separated from other components of a biological system." + }, + { + "input": "Concept: BiologicEntity (Organism)", + "output": "Entity described as any individual living (or previously living) being. EXAMPLE(S): animal, human being OTHER NAME(S): organism NOTE(S):" + }, + { + "input": "Concept: Vanishing Twin Syndrome (Unspecified Abortion)", + "output": "Stillbirth and foetal death described as a multiple pregnancy that over time is spontaneously reduced by one or more embryos which are then resorbed." + }, + { + "input": "Concept: Simpson Dysmorphia Syndrome (Genetic Diseases, X-Linked)", + "output": "Genetic Diseases, X-Linked described as an encephalo-tropho-schisis syndrome with pre- or postnatal overgrowth, coarse (\"bulldog-like\") facies with protruding jaw and tongue, occasional mental retardation, and congenital abnormalities of the extremities and other parts with variable expression." + }, + { + "input": "Concept: response to salt (response to chemical)", + "output": "Cell Function described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus." + }, + { + "input": "Concept: CDRS111A (CDRS-R Clinical Classification Question)", + "output": "CDRS-R Clinical Classification Question described as children's Depression Rating Scale, Revised (CDRS-R) Depressed feelings comment." + }, + { + "input": "Concept: dressing surgical (Device Labeled for Single Use)", + "output": "Device Labeled for Single Use described as dresses designed to be worn by medical personnel. Scrub dresses are made of reusable woven materials (e.g., polyester, cotton, a combination of both). They have minimal places for dirt to adhere to and are easy to launder. Scrub dresses are usually stain resistant; they sometimes have pockets, belts, ties, and side vents. Some healthcare facilities require the use of uniform scrub dresses." + }, + { + "input": "Concept: Product containing sulfur hexafluoride (Sulfur Compounds)", + "output": "Contrast Media described as a contrast agent composed of an inorganic fluorinated inert gas comprised of six fluoride atoms bound to one sulfur atom, with potential diagnostic activity upon imaging. Upon inhalation of sulfur hexafluoride (SF6), the gas is distributed throughout the lungs. Upon subsequent ultrasound imaging, the lung vasculature can be imaged and pulmonary perfusion can be assessed. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C84187\" active clinical trials using this agent." + }, + { + "input": "Concept: Adenocarcinoma and Small Cell Carcinoma of the Lung (combined small cell carcinoma of lung)", + "output": "combined small cell carcinoma of lung described as a lung carcinoma characterized by a combination of small cell carcinoma and adenocarcinoma." + }, + { + "input": "Concept: Tape Recording Data Processors (Manufactured Object)", + "output": "something described as data processors designed to acquire and process digital data obtained from signals (e.g., electrocardiographic, electroencephalographic) previously recorded on tape. Data is transferred from the recorder (usually an ambulatory recorder) to the processor (also known as a scanner) for quantification, processing, display, and storage using dedicated software; the processor may also generate reports. Tape recording processors are used to analyze taped continuous and event data; they are intended mainly for the detection of temporary abnormalities and to check the progress of therapy over a relatively long period of time (e.g., 48 or 72 hours). Tape recording processors dedicated for electrocardiographic or electroencephalographic tapes are also available." + }, + { + "input": "Concept: BIOEQUIVALENT ALLERGY UNITS (Allergy Unit)", + "output": "something described as a unit used for standardization of an allergenic product based on evaluation of product potency against reference standard in combined in vivo (skin test) and in vitro (IgE-based ELISA) testing." + }, + { + "input": "Concept: DRRI-2 - L: Care Child/Dependents Receiving (DRRI-2 Questionnaire Question)", + "output": "something described as deployment Risk & Resilience Inventory-2 - During deployment, I was concerned about: the care that my child(ren) or other dependents were receiving." + }, + { + "input": "Concept: Long-Chain Acyl CoA (Coenzymes)", + "output": "high energy compound described as s-Acyl coenzyme A. Fatty acid coenzyme A derivatives that are involved in the biosynthesis and oxidation of fatty acids as well as in ceramide formation." + }, + { + "input": "Concept: Fetal Chorionic Vasculitis (Disease or Syndrome)", + "output": "something described as a neutrophilic infiltrate arising from fetal vessels in the chorionic plate and oriented towards the amniotic cavity." + }, + { + "input": "Concept: campestanol hydroxylase activity (Molecular Function)", + "output": "something described as catalysis of the reaction: H+ + campestanol + O2 + NADPH <=> 6-deoxycathasterone + H2O + NADP." + }, + { + "input": "Concept: thoracic pain (Pain and discomfort NEC)", + "output": "Pain and discomfort NEC described as sensation of unpleasant feeling indicating potential or actual damage to some body structure felt in the chest." + }, + { + "input": "Concept: Food Does Not Taste Good (Intellectual Product)", + "output": "something described as a question about whether food does not taste very good to an individual." + }, + { + "input": "Concept: Undifferentiated Carcinoma of the Prostate (Neoplastic Process)", + "output": "something described as an invasive prostate carcinoma characterized by the presence of undifferentiated malignant cells." + }, + { + "input": "Concept: MDM4 (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as protein Mdm4 (490 aa, ~55 kDa) is encoded by the human MDM4 gene. This protein plays a role in the mediation of cell cycle arrest." + }, + { + "input": "Concept: Congenital septal defects (Congenital anomaly of trunk)", + "output": "Heart described as a congenital disorder characterized by the presence of an abnormal communication between the atria or the ventricles of the heart due to defects in the cardiac septum." + }, + { + "input": "Concept: assembly of starch utilization system complex (protein-containing complex assembly)", + "output": "protein-containing complex assembly described as the aggregation, arrangement and bonding together of the starch utilization system complex, a complex of cell envelope-associated proteins that degrades glycan." + }, + { + "input": "Concept: GUSTOMETER, STERILE (Electromechanical Devices)", + "output": "something described as a gustometer is a battery-powered device that consists of two electrodes that are intended to be placed on both sides of the tongue at different taste centers and that provides a galvanic stimulus resulting in taste sensation. It is used for assessing the sense of taste." + }, + { + "input": "Concept: Nasal catheter (Ear, nose and throat catheter)", + "output": "Device associated with nasal catheters described as catheters designed to be introduced into the nostrils that are long enough to keep the distal tip inside the nasal cavities, including the nasal sinuses. These devices are typically a soft plastic or rubber tube that may include a balloon attached to its distal tip. Dedicated nasal catheters are available to control nose bleeding, to supply oxygen, and to dilate the nasal sinus passages (usually introduced through nasal endoscopes)." + }, + { + "input": "Concept: beta3-adrenergic receptor activity (beta adrenoceptor activity)", + "output": "Molecular Function described as combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors." + }, + { + "input": "Concept: glutamine metabolism (glutamine family amino acid metabolic process)", + "output": "Molecular Function described as the chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." + }, + { + "input": "Concept: SOR (Molecular Function)", + "output": "oxidoreductase activity described as catalysis of the reaction: 4 sulfur + 4 H2O + O2 = 2 hydrogen sulfide + 2 bisulfite + 2 H+." + }, + { + "input": "Concept: Aneurysm Bifurcation Intracranial Stents (Stents, Vascular, Intracranial Artery)", + "output": "Medical Device described as vascular stents designed for deployment into the intracranial arteries at or near a vessel bifurcation to provide a bypass across the neck of a wide-neck aneurysm, allowing the aneurysm to be filled with coils or other appropriate particles. Clots formed around the implanted coils are intended to provide aneurysm sealing. Intracranial aneurysm bifurcation stents are usually flexible nitinol self-expanding stents with a hybrid cell structure that allows the pass of the coils into the aneurysm; they are used when open intracranial surgery is not possible or desirable." + }, + { + "input": "Concept: Rash Acneiform, CTCAE (Finding)", + "output": "Finding described as a disorder characterized by an eruption of papules and pustules, typically appearing in face, scalp, upper chest and back." + }, + { + "input": "Concept: medically uninsured (Persons)", + "output": "something described as individuals or groups with no or inadequate health insurance coverage. Those falling into this category usually comprise three primary groups: the medically indigent (MEDICAL INDIGENCY); those whose clinical condition makes them medically uninsurable; and the working uninsured." + }, + { + "input": "Concept: Hounsfield unit (Quantitative Concept)", + "output": "Numeric Value described as term given to the dimensions of the quantifier of x-ray attenuation, CT number." + }, + { + "input": "Concept: WD7-Walking a Long Distance (Intellectual Product)", + "output": "Intellectual Product described as world Health Organization Disability Assessment Schedule 2.0 - 36-Item Self - In the past 30 days, how much difficulty did you have in: Walking a long distance such as a kilometre [or equivalent]?" + }, + { + "input": "Concept: Yarrowias (Fungus)", + "output": "Dipodascaceae described as a genus of ascomycetous yeast in the family Dipodascaceae, order SACCHAROMYCETALES." + }, + { + "input": "Concept: Peritoneal sac structure (Serous sac)", + "output": "Body Part, Organ, or Organ Component described as serous sac, which has as parts the peritoneum and the peritoneal cavity. Examples: There is only one peritoneal sac." + }, + { + "input": "Concept: Allopathic & Osteopathic Physicians; Pathology, Immunopathology (Physicians; Physician/Osteopath)", + "output": "Physicians; Physician/Osteopath described as a pathologist who specializes in the diagnosis of immunologic diseases." + }, + { + "input": "Concept: FAC03903 (FKSI-15 Questionnaire Question)", + "output": "something described as functional Assessment of Cancer Therapy-Kidney Symptom Index-15 - I have pain." + }, + { + "input": "Concept: Absent/small spleen (Abnormal spleen morphology)", + "output": "something described as absence or underdevelopment of the spleen." + }, + { + "input": "Concept: Tyrosine Kinase 2 Gene Mutation (Gene Mutant)", + "output": "Gene Mutant described as a change in the nucleotide sequence of the TYK2 gene." + }, + { + "input": "Concept: BIOL TRANSPORT (General Metabolic Functions and Activities)", + "output": "General Metabolic Functions and Activities described as the directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter, pore or motor protein." + }, + { + "input": "Concept: Carboplatin-Paclitaxel-Etoposide (Therapeutic or Preventive Procedure)", + "output": "Therapeutic or Preventive Procedure described as a regimen consisting of carboplatin, paclitaxel and etoposide used for the treatment of extensive-stage small cell lung cancer." + }, + { + "input": "Concept: Prostaglandin PGE>3< (Prostaglandins E)", + "output": "lipids and lipoproteins described as an eicosanoid that is generated by the action of cyclooxygenases on the omega-3 fatty acid eicosapentaenoic acid (EPA). Prostaglandin E3 regulates ocular pressure, exerts anti-inflammatory activities and may inhibit tumor cell proliferation. Prostaglandin E3 may be used as a biomarker for EPA to evaluate the association between EPA and its antineoplastic activity." + }, + { + "input": "Concept: INDIA INK STAIN (Special Histology Staining Method)", + "output": "Laboratory Procedure described as a microscopy staining method that utilizes India Ink, a water soluble carbon-based black ink, to determine the presence of microorganisms that are surrounded by a gelatinous capsule. This is a negative staining method in which background is stained in black and the microbes and microscopic structures of interest remain white." + }, + { + "input": "Concept: adenosine 5'-monophosphoramidase activity (Molecular Function)", + "output": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides described as catalysis of the reaction: adenosine 5'-monophosphoramidate = AMP + NH2. Other substrates include AMP-morpholidate, AMP-N-alanine methyl ester and AMP-alpha-acetyl lysine methyl ester." + }, + { + "input": "Concept: positive regulation of phialide development (regulation of phialide development)", + "output": "positive regulation of conidiophore development described as any process that activates or increases the frequency, rate or extent of phialide development, a process that leads to the formation of phialides. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip." + }, + { + "input": "Concept: Mesenchyme (Embryonic Structure)", + "output": "something described as mesodermal tissue or tissue with mesodermal origin." + }, + { + "input": "Concept: OTU deubiquitinase w/ linear linkage specificity related autoinflam syndrome (Inflammatory disorder of immune system)", + "output": "Autosomal recessive hereditary disorder described as disease with characteristics of abnormal inflammation throughout the body. The uncontrolled inflammation can damage body tissue and organs, including the gastrointestinal system, joints and skin. Onset is usually within the first few weeks of life with recurring episodes of fever, diarrhoea, painful, swollen joints and skin rash. Lipodystrophy is present in some individuals. Caused by mutation in the OTULIN gene, the protein produced from this gene helps control inflammation. Inherited in an autosomal recessive pattern." + }, + { + "input": "Concept: Oral Gum Dosage Form (Biomedical or Dental Material)", + "output": "something described as solid single-dose preparation with a gum-like consistency, intended to be sucked or chewed before being swallowed. Medicated chewing gum is excluded." + }, + { + "input": "Concept: hypothalamic pituitary axis (Organ or Tissue Function)", + "output": "something described as neuroendocrine system of neurons, fiber tracts, endocrine tissue, and blood vessels which produces and releases pituitary hormones into the systemic circulation." + }, + { + "input": "Concept: FAC08428 (Intellectual Product)", + "output": "Intellectual Product described as functional Assessment of Chronic Illness Therapy-Dyspnea 10 Item Short Form - Part II Functional Limitation. Considering your shortness of breath over the past 7 days, rate the amount of difficulty you had when doing the following activities: Lifting something weighing 10-20 lbs (about 4.5-9kg, like a large bag of groceries)." + }, + { + "input": "Concept: Cicuta maculata (Cicuta)", + "output": "Plant described as cicuta maculata is toxic. Its foliage contains a complex unsaturated alcohol that causes convulsions." + }, + { + "input": "Concept: Airway clearance impairment (Nursing Assessment Entity)", + "output": "Nursing Assessment Entity described as inability to clear secretions or obstructions from the respiratory tract to maintain a clear airway." + }, + { + "input": "Concept: POLYMER, ENT SYNTHETIC-POLYAMIDE (Biomedical or Dental Material)", + "output": "Biomedical or Dental Material described as ear, nose, and throat synthetic polymer material is a device material that is intended to be implanted for use as a space-occupying substance in the reconstructive surgery of the head and neck. The device is used, for example, in augmentation rhinoplasty and in tissue defect closures in the esophagus. The device is shaped and formed by the suregon to conform to the patient's needs. This generic type of device is made of material such as polyamide mesh or foil and porous polyethylene." + }, + { + "input": "Concept: Aplasia of the retina (Finding)", + "output": "something described as a developmental defect characterized by absence of the retina." + }, + { + "input": "Concept: StudyConduct (Research Activity)", + "output": "performance - action described as an ongoing and/or past performance of a formal investigation as specified in a study protocol. EXAMPLE(S): OTHER NAME(S): NOTE(S): The term \"protocol\" is somewhat overloaded and must be qualified to provide semantic context. Therefore the term \"study protocol\" was chosen to disambiguate it from other protocols. The notion of a study protocol includes (but is not limited to) the design, statistical considerations, activities to test a particular hypothesis or answer a particular question that is the basis of the study, characteristics, specifications, objective(s), background, pre-study/study/post-study portions of the plan (including the design, methodology, statistical considerations, organization). The study may be of any type that involves subjects, including prevention, therapeutic, interventional or observational. Subjects involved in the study protocol may be biological entities (human, animal, specimen, tissue, organ, etc.) or products. The study protocol is related to other supporting documents, including (but not limited to) informed consent documents, case report forms (CRFs), regulatory and approval documentation, correlative studies, etc. (via the inherited association to DocumentVersionRelationship). The complete notion of the study protocol is represented in BRIDG by the classes StudyProtocol, StudyProtocolVersion, StudyProtocolDocument, StudyProtocolDocumentVersion, StudyConduct and all their associations. - The StudyProtocol class represents the content of the study protocol which includes characteristics and plan of the study which can be distilled into or abstracted from a version of the study protocol document and can exist even before the information is put into document form. - The StudyProtocolVersion class represents the details of the study protocol that may change over time. - The StudyProtocolDocument class represents the document form of the study protocol and is a grouping of the various study protocol document versions. - The StudyProtocolDocumentVersion class represents the document form of the study protocol version and is the details of the study protocol document that may change over time. - The StudyConduct class represents the execution of a study based on a study protocol definition which includes the scheduled and performed activities that are subject-specific as well as study-level and site-level activities." + }, + { + "input": "Concept: Have you had skin problems on or in the area of your affected breast (Intellectual Product)", + "output": "Clinical or Research Assessment Question described as a question about whether an individual has or had skin problems on or in the area of their affected breast." + }, + { + "input": "Concept: ED2-Know When to Use Toilet (Intellectual Product)", + "output": "Intellectual Product described as expanded Disability Rating Scale - Postacute Interview Survivor Version - Do you know when to use the toilet or to conduct bowel and bladder management?" + }, + { + "input": "Concept: familial Waldenstr\u00f6m macroglobulinemia (Waldenstrom Macroglobulinemia)", + "output": "Hereditary Malignant Neoplasm described as waldenstrom macroglobulinemia in a patient who has at least one first degree relative with either Waldenstrom macroglobulinemia or another B-cell lymphoproliferative disorder." + }, + { + "input": "Concept: Wechsler Preschool and Primary Scale of Intelligence (Intelligence Scale)", + "output": "something described as an intelligence test published by Harcourt Assessment and designed for children ages 2 years 6 months to 7 years 3 months. It provides subtest and composite scores that represent intellectual functioning in verbal and performance cognitive domains, and provides a composite score that represents a child's general intellectual ability." + }, + { + "input": "Concept: GRB10 gene (Adaptor Signaling Protein Gene)", + "output": "Gene or Genome described as this gene is involved in signal transduction. It plays a role in the regulation of both apoptosis and cell proliferation." + }, + { + "input": "Concept: Stage I Colon Neuroendocrine Tumor AJCC v8 (Stage I Colorectal Neuroendocrine Tumor AJCC v8)", + "output": "something described as stage I includes: T1, N0, M0. T1: Tumor invading the lamina propria or submucosa and measuring 2 cm or less. N0: No regional lymph node metastasis. M0: No distant metastasis." + }, + { + "input": "Concept: Tumor Necrosis Factor Receptor Superfamily Member 1B Measurement (Protein or Enzyme Type Measurement)", + "output": "Protein or Enzyme Type Measurement described as the determination of the amount of tumor necrosis factor receptor superfamily member 1B present in a sample." + }, + { + "input": "Concept: FXR and LXR Regulation of Cholesterol Metabolism (Metabolic Pathway)", + "output": "Molecular Function described as cholesterol is essential for life but a key in the development of heart disease. Cholesterol homeostasis is achieved through regulation of cholesterol uptake, cholesterol biosynthesis, cholesterol conversion to bile acids and excretion of bile acids. Inhibition of cholesterol biosynthesis up regulates LDLR expression and is the mechanism of action of many drugs used to lower plasma LDL to reduce coronary heart disease. Many aspects of cholesterol homeostasis are regulated by the nuclear receptors FXR and LXR, both nuclear receptor transcription factors that form heterodimers with the retinoic acid RXR receptors and that are activated by cholesterol metabolites. One of the primary tissues in cholesterol metabolism is the liver, a key site of cholesterol biosynthesis and where cholesterol low-density lipoprotein (LDL) is taken up from the plasma by the LDL-receptor. When cholesterol accumulates in liver cells, some of the cholesterol is oxidized to create oxysterols. Oxysterols activate LXR through LXR/RXR heterodimers to activate genes such as the CYP7A1 enzyme that catalyzes the rate-limiting step in bile acid biosynthesis and a major route for the elimination of cholesterol. Animals lacking the CYP7A1 enzyme accumulate cholesterol in the liver. In the intestine LXR activates the ABC-1 gene, a transporter that actively transports cholesterol out of cells to clear it from the body. Activation of ABC-1 expression by LXR in macrophages in atherosclerotic plaques appears to be another mechanism by which LXR plays a role in heart disease. The FXR receptor is activated by bile acids. In the liver, activation of FXR-RXR heterodimers by bile acids results in the feedback inhibition of CYP7A expression and reduced biosynthesis of bile acids. In the intestine, FXR activates expression of I-BABP, a protein that increases the transport of bile acids back to the liver from the intestine, reducing their excretion. Drugs targeting the FXR and LXR receptors could play an important role in modulating cholesterol homeostasis and heart disease in the future." + }, + { + "input": "Concept: OLFACTORY BULB (Segment of neural tree organ)", + "output": "Olfactory Pathways described as refers, in the human and macaque, to a small oval white structure located in the cleft between the ventral surface of the frontal lobe and the floor of the cranial cavity ( Carpenter-1983 ). In the rat and mouse it is a much larger structure in comparison to rest of the brain; there it occupies almost a quarter of the length of the cranial cavity ( Swanson-2004 ). Though classically considered a separate structure from the cerebral cortex in primates ( Nomina-1983 ), it is classified on the basis of internal structure as a component of paleocortex in all species ( Stephan-1975 ). In all species it is connected rostrally with the olfactory nerve. Caudally in primates it connects with the olfactory peduncle; in rodents it connects through the olfactory tract directly to the olfactory tubercle and olfactory areas (rodent) of the cerebral cortex ( Swanson-2004 ). It is a layered structure that contains cell bodies of the second neurons in the olfactory system. It is a key structure in the system that mediates the sense of smell." + }, + { + "input": "Concept: F 1 ATPase (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as the catalytic sector of proton-translocating ATPase complexes. It contains five subunits named alpha, beta, gamma, delta and eta." + }, + { + "input": "Concept: Chemotherapy management (rnrx medication)", + "output": "Health Care Activity described as managing, monitoring and/or caring for a patient while he or she is undergoing chemotherapy." + }, + { + "input": "Concept: Intraosseous Benign Notochordal Cell Tumor (Benign bone neoplasm)", + "output": "Notochordal Tumor described as an intraosseous benign tumor of notochord origin that arises in the bones of the base of the skull, vertebral bodies, sacrum or coccyx. It contains vacuolated tumor cells without atypia, but lacks myxoid matrix, necrosis, and lobular architecture, which are features that characterize its malignant counterpart, chordoma. Most lesions are incidental findings." + }, + { + "input": "Concept: DNA-directed RNA polymerase activity involved in transcription from RNA polymerase II promoter (DNA-directed RNA polymerase activity)", + "output": "DNA-directed RNA polymerase activity described as catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." + }, + { + "input": "Concept: SMARCB Positive (Positive Laboratory Test Result)", + "output": "something described as an indication that expression of SMARCB1 has been detected in a sample." + }, + { + "input": "Concept: Infertility Risk (Finding)", + "output": "Finding described as decreased chance of conception to develop an offspring/child" + }, + { + "input": "Concept: Minute Times Mole Per Liter Per Gram (Measurement Unit Description)", + "output": "Quantitative Concept described as minutes times moles per liter (area under the curve), divided by grams (weight)." + }, + { + "input": "Concept: Sea-Food (Food)", + "output": "Prepared fish described as marine fish and shellfish used as food or suitable for food. (Webster, 3d ed) SHELLFISH and FISH PRODUCTS are more specific types of SEAFOOD." + }, + { + "input": "Concept: Oropharyngeal Cancer pT4a TNM Finding v6 (Finding)", + "output": "something described as oropharyngeal cancer with tumor invading the larynx, deep/extrinsic muscle of tongue, medial pterygoid muscles, hard palate, or mandible." + }, + { + "input": "Concept: MAPK/ERK Kinase Inhibitor (Protein Kinase Inhibitors)", + "output": "Pharmacologic Substance described as any substance that inhibits mitogen-activated protein kinase kinase (MEK), an enzyme that catalyzes the addition of a phosphate group to a mitogen-activated protein kinase. Inhibition of mitogen-activated protein kinase kinase results in the inhibition of cell proliferation." + }, + { + "input": "Concept: netilmicin sulfate (N [Preparations])", + "output": "netilmicin described as the sulfate salt form of netilimicin, a semisynthetic, water soluble aminoglycoside antibiotic. Netilmicin is derived from sisomicin, a naturally occurring aminoglycoside antibiotic produced by the fermentation of Micromonospora inyoensis. Netilmicin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, netilmicin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death." + }, + { + "input": "Concept: Complement C4a measurement (C4 complement assay)", + "output": "LABORATORY IMMUNOLOGIC PROCEDURES described as the determination of the amount of complement C4a present in a sample." + }, + { + "input": "Concept: 52B-52D CLASS SPOROZOEA - SUBCLASS PIROPLASMIA (Sporozoea)", + "output": "Sporozoea described as a subclass of heteroxenous parasitic protozoa usually transmitted by ticks. Its organisms are rod-shaped or amoeboid with conoid, oocysts, spores, and pseudocysts absent. Locomotion is by body flexion, gliding, or, in sexual stages, by large axopodium-like organelles." + }, + { + "input": "Concept: Division (Population Group)", + "output": "something described as an administrative unit within a government, academic organization or business." + }, + { + "input": "Concept: HAMA105 (Intellectual Product)", + "output": "something described as hamilton Anxiety Rating Scale - Intellectual: difficulty in concentration, poor memory." + }, + { + "input": "Concept: Stripping, NOS (Excision)", + "output": "Excision described as a removal done by peeling, often using a stripper" + }, + { + "input": "Concept: Cancer Pain Group (Clinical Attribute)", + "output": "something described as group I: Patients with acute cancer-related pain - associated with diagnosis and/or therapy. Group II: Patients with chronic cancer-related pain - associated with cancer progression and/or therapy. Group III: Patients with preexisting chronic pain and cancer pain. Group IV: Patients with a history of drug addiction and cancer-related pain. This includes those currently using, in treatment, and former users. Group V: Dying patients with cancer-related pain." + }, + { + "input": "Concept: counseling (Coping Component)", + "output": "Counseling described as the process by which a professional counselor helps a person cope with mental or emotional distress, and understand and solve personal problems." + }, + { + "input": "Concept: TRIBOA-glucoside methyltransferase activity (Molecular Function)", + "output": "something described as catalysis of the reaction: TRIBOA-beta-D-glucoside + S-adenosyl-L-methionine <=> (2R)-DIMBOA glucoside + S-adenosyl-L-homocysteine + H+." + }, + { + "input": "Concept: ED104 2 (Expanded DRS-PI Caregiver Version Questionnaire Question)", + "output": "Intellectual Product described as expanded Disability Rating Scale - Postacute Interview Caregiver Version (Expanded DRS-PI Caregiver Version) Does [name] understand what eating or feeding utensils or equipment are for and how they should be used?" + }, + { + "input": "Concept: papillary serous carcinoma (Papillary Serous Cystadenocarcinoma)", + "output": "Extraovarian primary peritoneal carcinoma described as a malignant cystic serous epithelial neoplasm characterized by the presence of malignant glandular epithelial cells forming papillary structures. Stromal invasion is present." + }, + { + "input": "Concept: Orange Sticks (Device Labeled for Single Use)", + "output": "Device Labeled for Single Use described as wooden sticks intended for medical and/or cosmetic uses. These devices are thin, flat sticks made of fine-grain wood (originally orange wood), providing a smooth finish and good tensile strength. Orange sticks may be used to apply ointments on the skin, for manicuring fingernails, or to depress the tongue during oral examination; they are also used in some biting tests that help determine proper mandible function (e.g., to assess possible mandible fracture)." + }, + { + "input": "Concept: Supplementation (Nutritional Intervention)", + "output": "Nutritional Support described as adding nutrients to the diet." + }, + { + "input": "Concept: SEND-ACPARMCD (Intellectual Product)", + "output": "CDISC SEND Terminology described as terminology related to the parameter codes of the challenge agent characteristics within a study." + }, + { + "input": "Concept: Grade 4 Upper Respiratory Infection, CTCAE (Finding)", + "output": "something described as life-threatening consequences; urgent intervention indicated" + }, + { + "input": "Concept: Protein Syld709613 (Signaling Protein)", + "output": "Signaling Protein described as protein NDRG2 (371 aa, ~41 kDa) is encoded by the human NDRG2 gene. This protein is involved in both dendritic cell differentiation and Wnt signaling." + }, + { + "input": "Concept: 4: 111191654-111291023 (Spatial Concept)", + "output": "something described as physical location of EGF_Gene" + }, + { + "input": "Concept: Short tubular bones of the hand (Short long bone)", + "output": "Short long bone described as decreased length of the tubular bones of the hand, that is, the phalanges and metacarpals." + }, + { + "input": "Concept: Adenovirus Vaccines (Immunologic Factor)", + "output": "something described as vaccines used to prevent infection by any virus from the family ADENOVIRIDAE." + }, + { + "input": "Concept: Finding relating to behavior (Psychological finding)", + "output": "Clinical history and observation findings described as the actions or reactions of an object or organism, usually in relation to the environment or surrounding world of stimuli." + }, + { + "input": "Concept: protons (Elements)", + "output": "Element or Ion described as a small, positively charged particle of matter found in the atoms of all elements. Streams of protons generated by special equipment can be used for radiation treatment." + }, + { + "input": "Concept: Mid-diastolic Murmur (Finding)", + "output": "Finding described as a heart murmur that occurs during the middle portion of the ventricular filling phase." + }, + { + "input": "Concept: SST receptor signaling pathway (GPCR Signaling Pathway)", + "output": "Molecular Function described as the series of molecular signals generated as a consequence of a somatostatin receptor (SSTR) binding to one of its physiological ligands and transmitting the signal to a heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription." + }, + { + "input": "Concept: WD1-How Many Days Reduce Activities (WHODAS 2.0 12-item Version Interviewer-administered Questionnaire Question)", + "output": "Intellectual Product described as world Health Organization Disability Assessment Schedule 2.0 12-item Version Interviewer-administered (WHODAS 2.0 12-item Version Interviewer-administered) In the past 30 days, not counting the days that you were totally unable, for how many days did you cut back or reduce your usual activities or work because of any health condition?" + }, + { + "input": "Concept: NAIP Protein (Apoptosis Regulatory Proteins)", + "output": "Amino Acid, Peptide, or Protein described as baculoviral IAP repeat-containing protein 1 (1403 aa, ~160 kDa) is encoded by the human NAIP gene. This protein is involved in the modulation of both apoptosis and neuronal development." + }, + { + "input": "Concept: Exercisers, Muscle Strength, Pneumatic, Trunk (Manufactured Object)", + "output": "Manufactured Object described as muscle strength exercisers designed to provide resistance to muscular contraction in the trunk using a pneumatic mechanism. These exercisers usually consist of a stand-alone machine with a pneumatic mechanism, a system to transmit the force (i.e., to convey the resistance), and lever bars on which the user exerts force to counteract the exerciser resistance. Pneumatic trunk muscle strength exercisers can be used to exercise the trunk (e.g., hip rotation, low back, abdominal crunch) muscles." + }, + { + "input": "Concept: Low-speed floor centrifuge, nonrefrigerated (Centrifuges, Floor, Low-Speed)", + "output": "Centrifuges, Floor, Low-Speed described as low-speed (typically up to 10,000 rpm) free-standing centrifuges designed to work at ambient temperature. These centrifuges are typically large stationary structures and consist of an electric motor, a shaft, a tachometer, and speed and time controls; they also include a rotor on which one of several interchangeable heads is mounted. Nonrefrigerated low-speed floor centrifuges are intended mainly for a variety of non-temperature-sensitive procedures such as centrifugation of body fluids, reagents, and/or mixtures of both in preparation for analysis using other equipment." + }, + { + "input": "Concept: TSCYC - Trouble Remember Upsetting Thing (TSCYC Questionnaire Question)", + "output": "something described as trauma Symptom Checklist for Young Children - Please indicate how often he or she has done, felt, or experienced each of the following things in the last month: Having trouble remembering an upsetting thing that happened in the past." + }, + { + "input": "Concept: PGP9.5 (UCHL1 gene)", + "output": "UCHL1 gene described as human UCHL1 wild-type allele is located in the vicinity of 4p13 and is approximately 12 kb in length. This allele, which encodes ubiquitin carboxyl-terminal hydrolase isozyme L1 protein, is involved in the deubiquitination of proteins. Mutation of the gene is associated with Parkinson disease type 5." + }, + { + "input": "Concept: Ascococcus mesenteroides (Leuconostoc)", + "output": "Bacterium described as any bacterial organism that can be assigned to the species Leuconostoc mesenteroides." + }, + { + "input": "Concept: 1-O-galloyl-beta-D-glucose:1-O-galloyl-beta-D-glucose O-galloyltransferase activity (Molecular Function)", + "output": "transferase activity, transferring acyl groups other than amino-acyl groups described as catalysis of the reaction: 2 1-O-galloyl-beta-D-glucose = 1,6-bis-O-galloyl-beta-D-glucose + D-glucose." + }, + { + "input": "Concept: Penis Circumcision Clamps (Medical Device)", + "output": "Clamps, Surgical, Penis described as an obstetric-gynecologic specialized manual instrument is one of a group of devices used during obstetric-gynecologic procedures to perform manipulative diagnostic and surgical functions (e.g., dilating, grasping, measuring, and scraping), where structural integrity is the chief criterion of device performance. This type of device consists of the following: (1) An amniotome is an instrument used to rupture the fetal membranes. (2) A circumcision clamp is an instrument used to compress the foreskin of the penis during circumcision of a male infant. (3) An umbilical clamp is an instrument used to compress the umbilical cord. (4) A uterine curette is an instrument used to scrape and remove material from the uterus. (5) A fixed-size cervical dilator is any of a series of bougies of various sizes used to dilate the cervical os by stretching the cervix. (6) A uterine elevator is an instrument inserted into the uterus used to lift and manipulate the uterus. (7) A gynecological surgical forceps is an instrument with two blades and handles used to pull, grasp, or compress during gynecological examination. (8) A cervical cone knife is a cutting instrument used to excise and remove tissue from the cervix. (9) A gynecological cerclage needle is a looplike instrument used to suture the cervix. (10) A hook-type contraceptive intrauterine device (IUD) remover is an instrument used to remove an IUD from the uterus. (11) A gynecological fibroid screw is an instrument used to hold onto a fibroid. (12) A uterine sound is an instrument used to determine the depth of the uterus by inserting it into the uterine cavity. (13) A cytological cervical spatula is a blunt instrument used to scrape and remove cytological material from the surface of the cervix or vagina. (14) A gynecological biopsy forceps is an instrument with two blades and handles used for gynecological biopsy procedures. (15) A uterine tenaculum is a hooklike instrument used to seize and hold the cervix or fundus. (16) An internal pelvimeter is an instrument used within the vagina to measure the diameter and capacity of the pelvis. (17) A nonmetal vaginal speculum is a nonmetal instrument used to expose the interior of the vagina. (18) A fiberoptic nonmetal vaginal speculum is a nonmetal instrument, with fiberoptic light, used to expose and illuminate the interior of the vagina." + }, + { + "input": "Concept: HAQ-DI With VAS - Aids or Devices - Used For Dressing (HAQ-DI Questionnaire Question)", + "output": "HAQ-DI Questionnaire Question described as health Assessment Questionnaire Disability Index With Pain Visual Analog Scale (HAQ-DI With VAS) AIDS or DEVICES that you usually use for any of these activities - Devices used for dressing (button hook, zipper pull, long-handled shoe horn, etc.)." + }, + { + "input": "Concept: Adhesion Performance Study (Research Activity)", + "output": "Clinical Trial Type described as a type of study designed to evaluate the strength of the bond between an adhesive and the application surface." + }, + { + "input": "Concept: RNA processing (Metabolism)", + "output": "Biochemical Processes described as any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." + }, + { + "input": "Concept: Structure of auditory vesicle (Embryonic Structure)", + "output": "Embryonic Structures described as a simple epithelial sac-like structure formed by the deepening and closure of the otic pit during early embryonic development, which will eventually form the membranous labyrinth of the inner ear." + }, + { + "input": "Concept: DARBEPOETIN ALFA,RECOMBINANT (OTHER ANTIANEMIC PREPARATIONS in ATC)", + "output": "Blood Products and Modifiers, Other described as a recombinant analog of the endogenous cytokine erythropoietin, an erythropoiesis-stimulating protein. Due to the addition of two carbohydrate chains, darbepoetin alfa exhibits a three-fold greater half-life than does erythropoietin. Similar to erythropoietin, darbopoietin alfa binds to and activates epoetin receptors, thereby inducing the differentiation and maturation of erythrocyte progenitors, stimulating endothelial cell proliferation, and stimulating B-cell proliferation and immunoglobulin production. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1878\" active clinical trials using this agent." + }, + { + "input": "Concept: LY3164530 (Antineoplastic Antibody)", + "output": "Amino Acid, Peptide, or Protein described as a monoclonal antibody (MoAb) against human epidermal growth factor receptor (EGFR) and human hepatocyte growth factor receptor (HGFR or c-Met), with potential antineoplastic activity. Upon administration, anti-Met/EGFR MoAb LY3164530 targets and prevents the activation of EGFR and c-Met. This leads to a downstream inhibition of EGFR/c-Met-mediated signal transduction pathways, and prevents cellular proliferation in tumor cells overexpressing EGFR and c-Met. EGFR, a member of the epidermal growth factor family of extracellular protein ligands, may be overexpressed on the cell surface of various solid tumor cell types. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis." + }, + { + "input": "Concept: Hexobendine (Organic Chemical)", + "output": "Other vasodilators used in cardiac diseases in ATC described as a potent vasoactive agent that dilates cerebral and coronary arteries, but slightly constricts femoral arteries, without any effects on heart rate, blood pressure or cardiac output." + }, + { + "input": "Concept: fluid (Substance)", + "output": "Substance described as a continuous amorphous substance that tends to flow and to conform to the outline of its container (i.e., a liquid or a gas). Also used as an adjective to describe something with properties like that of a fluid." + }, + { + "input": "Concept: VLP (Drug Delivery Systems)", + "output": "something described as non-infectious particle(s) derived from viral structural proteins. These particles are used as vaccines to stimulate a host immune response against the virus that the particles were derived from." + }, + { + "input": "Concept: integrin, beta 5 (Gene or Genome)", + "output": "Gene or Genome described as this gene is involved in cell communication and signal transduction." + }, + { + "input": "Concept: 3-chlorobenzoate-3,4-oxygenase activity (Molecular Function)", + "output": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor described as catalysis of the reaction: 3-chlorobenzoate + O2 + a reduced electron acceptor <=> 3-chlorobenzoate-cis-3,4-diol + an oxidized electron acceptor." + }, + { + "input": "Concept: eosinophilic; pneumonia (Hypersensitivity)", + "output": "Disease or Syndrome described as an inflammatory lung disorder characterized by an increased number of eosinophils in the lungs. The majority of cases are idiopathic, without identifiable cause. In a minority of cases, medications, fungal infections, and environmental triggers have been implicated. It manifests as acute or chronic. Acute eosinophilic pneumonia is a severe and rapidly progressing pneumonia that may lead to respiratory failure requiring mechanical ventilation. Chronic eosinophilic pneumonia follows a slower course and manifests as fever, dyspnea, cough, and weight loss." + }, + { + "input": "Concept: Grade 4 Neck Edema, CTCAE (Neck Edema, CTCAE)", + "output": "something described as vascular or respiratory impairment requiring urgent intervention" + }, + { + "input": "Concept: Dasyproctidae (Rodent)", + "output": "Mammal described as a family of Central and South American plant-eating rodents comprising the agoutis (Dasyprocta) and acouchis (Myoprocta). They look similar to guinea pigs (CAVIA) but are larger and have longer legs. Their fur is reddish or dark brown." + }, + { + "input": "Concept: Regulatory Protein E2, Human Papillomavirus Type 18 (Biologically Active Substance)", + "output": "Papillomavirus Protein E2 described as regulatory protein E2 (365 aa, ~42 kDa) is encoded by the human papillomavirus type 18 E2 gene. This protein plays a role in both transcription and replication of viral genes." + }, + { + "input": "Concept: yellow nails (Color of nail)", + "output": "Nail plate described as yellowish discoloration of the nails." + }, + { + "input": "Concept: IVD Panels, Human Genetics, Metabolic Disorder, Porphyria, Comprehensive, Mutation (Medical Device)", + "output": "Medical Device described as molecular assay reagents intended to identify mutations in the majority of genes known to be associated with porphyria, a collection of genetic diseases caused by deficiencies in heme production. Genetic variants at multiple loci have been associated with porphyria. These reagents are intended to detect mutations in multiple porphyria-associated loci simultaneously." + }, + { + "input": "Concept: Licensing Factor Gene (Gene or Genome)", + "output": "something described as licensing Factor Genes encode Licensing Factors that are required, after a prior round of mitosis, in G(1) for DNA replication licensing, are removed after passage through S-phase, and are central to ensuring that replication occurs once per cell cycle." + }, + { + "input": "Concept: A Little Energy (Clinical or Research Assessment Answer)", + "output": "Finding described as a response indicating that an individual has or had a little energy." + }, + { + "input": "Concept: Radiotherapy Systems, Linear Accelerator, Intraoperative (Medical Device)", + "output": "something described as adiotherapy systems designed to administer ionizing radiation during a surgical procedure by means of electron beams of varying energies and/or high-energy photons using a linear accelerator (linac) as a generator. These systems typically include a dedicated stationary linear accelerator, limiting its use to only one shielded operating room. The intraoperative linear accelerator main components are similar to standard linear accelerators (i.e., a modulator, an electron gun, a radio-frequency power source, and an accelerator guide); the electron beam is further collimated to the desired size by applicators inserted into the patient. Intraoperative radiotherapy systems are intended to provide a high dose of radiation in a single procedure with high target accuracy and low risk of damage to the adjacent tissues." + }, + { + "input": "Concept: Cationic Lipopeptides (Amino Acid, Peptide, or Protein)", + "output": "something described as lipopeptides with an cationic peptide scaffold." + }, + { + "input": "Concept: 11: 27699851-27633020 (Chromosome 11 Physical Location)", + "output": "Chromosome 11 Physical Location described as physical location of BDNF_Gene" + }, + { + "input": "Concept: Undefined water modality narrative required (Hydrotherapy)", + "output": "Hydrotherapy described as any elsewhere undefined water modality, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com." + }, + { + "input": "Concept: Monoclonal Antibody BMS-986218 (Immunologic Factor)", + "output": "Pharmacologic Substance described as a Fc-modified monoclonal antibody directed against the human T-cell receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-CTLA4 monoclonal antibody BMS-986218 targets and binds to CTLA4 expressed on T-cells and inhibits the CTLA4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA4, an inhibitory receptor and member of the immunoglobulin superfamily, plays a key role in the downregulation of the immune system. Removal of the fucose sugar units from the antibody's Fc region, enhances its activity and decreases the toxicity of BMS-986218." + }, + { + "input": "Concept: unc-119 lipid binding chaperone (Trafficking Protein Gene)", + "output": "Trafficking Protein Gene described as this gene plays a role in protein trafficking." + }, + { + "input": "Concept: cyclophosphamide/doxorubicin/prednisone/vincristine (Therapeutic or Preventive Procedure)", + "output": "Therapeutic or Preventive Procedure described as a chemotherapy regimen consisting of cyclophosphamide, hydroxydaunorubicin hydrochloride (doxorubicin hydrochloride), vincristine and prednisone used to treat both indolent and aggressive forms of non-Hodgkin lymphoma." + }, + { + "input": "Concept: ABCG2 gene (Translocase Gene)", + "output": "Translocase Gene described as this gene plays a role in xenobiotic transport and multi-drug resistance." + }, + { + "input": "Concept: Pseudocyst (Cyst)", + "output": "Acquired Abnormality described as a cyst-like structure that lacks an epithelial lining." + }, + { + "input": "Concept: FIBROBLAST GROWTH FACTOR A 003 (Biologically Active Substance)", + "output": "Fibroblast Growth Factor described as a fibroblast growth factor that is expressed primarily during development." + }, + { + "input": "Concept: Dideoxynucleotides (Nucleotides)", + "output": "something described as the phosphate esters of DIDEOXYNUCLEOSIDES." + }, + { + "input": "Concept: Phenomenon, Pharmacotoxicologic (Biologic Function)", + "output": "Biologic Function described as synthesis, metabolism, and poisoning associated with drugs, pharmaceuticals, and other active molecules. Toxicological phenomena also include the adverse effects of physical phenomena such as RADIATION and NOISE." + }, + { + "input": "Concept: AVL01098 (ADNI-AVLT Questionnaire Question)", + "output": "Intellectual Product described as alzheimer's Disease Neuroimaging Initiative Auditory Verbal Learning Test Version A (ADNI-AVLT Version A) List A, Recall 6 (after B Recall), Word 13." + }, + { + "input": "Concept: Embryo Development, Preimplantation (Physiologic Function)", + "output": "something described as the cellular development between the time of mammalian gamete FERTILIZATION and EMBRYO IMPLANTATION. This represents the development in the FALLOPIAN TUBES." + }, + { + "input": "Concept: RNA PROC POST (Biochemical Phenomena)", + "output": "Gene Expression Regulation described as any alterations made to primary RNA transcripts before leaving the nucleus as mature mRNA; e.g., removing of introns, splicing of exons, addition of cap or a poly-A tail." + }, + { + "input": "Concept: EGARMN (ECG Measurement)", + "output": "Quantitative Concept described as an electrocardiographic measurement of the average rate of atrial depolarizations (P waves) recorded during an interval of time, usually expressed in beats per minute." + }, + { + "input": "Concept: hGHr (Hormonal Agents, Stimulant/Replacement/ Modifying)", + "output": "Hormone described as mammalian-cell derived recombinant human growth hormone." + }, + { + "input": "Concept: Genus Muntiacus (Mammal)", + "output": "Mammal described as a genus, Muntiacus, of the deer family (Cervidae) comprising six species living in China, Tibet, Nepal, India, the Malay Peninsula, and neighboring island countries. They are usually found in forests and areas of dense vegetation, usually not far from water. They emit a deep barklike sound which gives them the name \"barking deer.\" If they sense a predator they will \"bark\" for an hour or more. They are hunted for their meat and skins; they thrive in captivity and are found in many zoos. The Indian muntjac is believed to have the lowest chromosome number in mammals and cell lines derived from them figure widely in chromosome and DNA studies." + }, + { + "input": "Concept: Complementation Test, Genetic (Laboratory Procedure)", + "output": "Laboratory Procedure described as a test used to determine whether or not complementation (compensation in the form of dominance) will occur in a cell with a given mutant phenotype when another mutant genome, encoding the same mutant phenotype, is introduced into that cell." + }, + { + "input": "Concept: Recurrent Testicular Cancer (Testicular and epididymal neoplasms)", + "output": "Testicular and epididymal neoplasms described as malignant testicular germ cell tumor reemerging after a period of remission." + }, + { + "input": "Concept: nuclear receptor activity (Molecular Function)", + "output": "Molecular Function described as combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." + }, + { + "input": "Concept: endoribonuclease complex location (endonuclease complex)", + "output": "Cell Component described as a protein complex which is capable of endoribonuclease activity." + }, + { + "input": "Concept: Order Spirurida (Eukaryote)", + "output": "something described as an order of nematodes of the subclass SECERNENTEA. Characteristics include ventral or caudoventral papillae and an esophagus divided into anterior muscular and posterior glandular parts." + }, + { + "input": "Concept: Follow-Up Outcome Expectations Questionnaire (Intellectual Product)", + "output": "Intellectual Product described as a set of questions and responses designed to evaluate an individual's self-reported expectations with the outcome of treatment." + }, + { + "input": "Concept: Blood Vessel Density (Histopathology)", + "output": "Diagnostic Procedure described as an evaluation of the blood vessel density in a biological specimen." + }, + { + "input": "Concept: Units, Erythroid Burst-Forming (Stem cells)", + "output": "Cell described as a unit of viable cell concentration defined as the minimum number of hematopoietic stem cells able to produce a detectable colony of erythroid burst forming cells." + }, + { + "input": "Concept: Messages, Text (Intellectual Product)", + "output": "Message described as a short electronic communication, usually sent and received by a mobile phone." + }, + { + "input": "Concept: 10m (area 10 of Carmichael)", + "output": "Body Part, Organ, or Organ Component described as a part of the superior frontal gyrus at the frontal pole that is defined on the basis of internal structure in the macaque. It is one of two components of area 10 (macaque) in the orbitomedial prefrontal cortex. The other component is area 10o (macaque) ( Carmichael-1994 ). Identifying features of area 10m are fiber plexi in the molecular layer of the cerebral cortex (I), the external pyramidal layer (III), the internal pyramidal layer (V) and the multiform layer (VI) that stain moderately for acetylcholinesterase and a second band of neuropil deep in the multiform layer (VI) that stains for chondroitin sulfate proteoglycan (8b3 antibody). Other features that distinguish it from some adjacent areas are radial striations revealed by Nissl stain in the external pyramidal layer (III) and the internal pyramidal layer (V) ( Carmichael-1994 ).\\r\\nIt is the topological equivalent of area 10m and area 10r in the human ( Ongur-2003 ). As granular prefrontal cortex, it has no equivalent in the rat ( Wallis-2012 )." + }, + { + "input": "Concept: NCoA 1 Protein (Biologically Active Substance)", + "output": "Amino Acid, Peptide, or Protein described as a nuclear receptor coactivator with specificity for ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and THYROID HORMONE RECEPTORS. It contains a HISTONE ACETYLTRANSFRASE activity that may play a role in the transcriptional activation of CHROMATIN regions." + }, + { + "input": "Concept: Scalene Muscle (Skeletal muscle structure of neck)", + "output": "Rotator of cervical intervertebral joint described as any one of three pairs of vertebral muscles (anterior, middle, and posterior scalenes), which attach to the transverse process of the five lower cervical vertebrae and the first two ribs, and which function to elevate the ribs during breathing and to laterally flex the neck." + }, + { + "input": "Concept: Ribosomal Protein S3 Gene (DNA Repair Gene)", + "output": "DNA Repair Gene described as this gene plays a role in DNA repair and positive regulation of apoptosis." + }, + { + "input": "Concept: Organ part (Body organ structure)", + "output": "Body Regions described as anatomical structure, which consists of one or more types of tissues, spatially related to one another in patterns determined by coordinated gene expression; together with other contiguous organ parts, it constitutes an organ. Examples:endothelium, osteon, cortical bone, neck of femur, bronchopulmonary segment, left lobe of liver, anterior interventricular branch of leftcoronary artery, right atrium, mitral valve." + }, + { + "input": "Concept: lysine 2,3-aminomutase activity (Molecular Function)", + "output": "intramolecular transferase activity, transferring amino groups described as catalysis of the reaction: L-lysine = (3S)-3,6-diaminohexanoate." + }, + { + "input": "Concept: Medication Dispenser (Person Role Title)", + "output": "Person Role Title described as healthcare providers who dispense or administer the drug, settings in which the drug is dispensed or administered, or authorized representatives of the setting in which the drug is dispensed or administered. This encompasses a wide range of settings, including outpatient pharmacies, chain pharmacies, independent pharmacies, mail-order pharmacies, clinics, infusion centers, hospitals, health systems, and closed health systems." + }, + { + "input": "Concept: Antileukemic Agent (Agent)", + "output": "Pharmacologic Substance described as substance that inhibits the development of or prevents leukemia." + }, + { + "input": "Concept: Dipyridamine (Platelet Aggregation Inhibitors)", + "output": "Pharmacologic Substance described as platelet inhibitor and coronary vasodilator used to prevent thromboembolism associated with mechanical heart valves, as prophylactic adjunct in the prevention of myocardial reinfarction, and as a diagnostic aid adjunct in myocardial perfusion imaging; administered orally and intravenously." + }, + { + "input": "Concept: GCA codon-amino acid adaptor activity (Genetic Function)", + "output": "Genetic Function described as a triplet codon-amino acid adaptor activity that recognizes a GCA codon." + }, + { + "input": "Concept: Brevibacteriaceae Breed 1953 (Approved Lists 1980) emend. Zhi et al. 2009 (Bacterium)", + "output": "something described as a taxonomic family of Gram positive bacterium in the phylum Actinobacteria that includes the genus Brevibacterium." + }, + { + "input": "Concept: Phenomena, Biomechanical (Biophysics)", + "output": "something described as the properties, processes, and behavior of biological systems under the action of mechanical forces." + }, + { + "input": "Concept: cavity (Anatomic Structure, System, or Substance)", + "output": "Trunk structure described as a natural hollow or sinus within the body." + }, + { + "input": "Concept: Biological Clearance Rate (Pharmaceutical Product Characteristics)", + "output": "something described as the rate at which an exogenous substance is removed or cleared from the whole or part of the body." + }, + { + "input": "Concept: CDISC Functional Test MMSE Test Code Terminology (CDISC Functional Test Terminology)", + "output": "Intellectual Product described as mini-Mental State Examination test code." + }, + { + "input": "Concept: copper ion export from vacuole (Cell Function)", + "output": "copper ion export described as the directed movement of copper ions out of the vacuole across the vacuolar membrane." + }, + { + "input": "Concept: Portion of tissue fluid proper (Interstitial Fluid)", + "output": "something described as tissue fluid of tissues other than connective tissue." + }, + { + "input": "Concept: Abnormality of toe proximal phalanx (Anatomical Abnormality)", + "output": "something described as a morphological anomaly of one or more proximal phalanges of one or more toes." + }, + { + "input": "Concept: High-dose Methylprednisolone/Obinutuzumab Regimen (Regimen Used to Treat Chronic Lymphocytic Leukemia)", + "output": "something described as a regimen consisting of high-dose methylprednisolone and obinutuzumab that can be used for the treatment of chronic lymphocytic leukemia (CLL)." + }, + { + "input": "Concept: receptor localization to non-motile cilium (protein localization to non-motile cilium)", + "output": "something described as a process in which a receptor is transported to, or maintained in, a location within a non-motile cilium." + }, + { + "input": "Concept: Penile Squamous Cell Carcinoma pN0 TNM Finding v8 (Penile Cancer Pathologic Regional Lymph Nodes TNM Finding v8)", + "output": "Finding described as penile cancer with no lymph node metastasis." + }, + { + "input": "Concept: 5-hydroxytryptamine receptor 2C (Gene or Genome)", + "output": "G Protein-Coupled Receptor Genes described as this gene is involved in neurotransmitter-dependent G protein-coupled receptor signaling." + }, + { + "input": "Concept: Wuhan Seafood Market Pneumonia Virus (Betacoronavirus)", + "output": "Betacoronavirus described as a positive-sense single-stranded RNA virus in the genus Betacoronavirus. It is the causative agent of the 2019-2020 severe acute respiratory syndrome outbreak." + }, + { + "input": "Concept: Apoptosis Promoter Gene (Gene or Genome)", + "output": "Gene or Genome described as apoptosis Promoter Genes encode Apoptosis Promoter proteins, which promote the initiation, progress, or rate of apoptosis." + }, + { + "input": "Concept: regulation of cell division (Cell Function)", + "output": "Cell Function described as any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells." + }, + { + "input": "Concept: negative regulation of pancreatic B cell development (negative regulation of epithelial cell differentiation)", + "output": "negative regulation of epithelial cell differentiation described as any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development." + }, + { + "input": "Concept: Urethral Cancer Clinical TNM Finding v7 (Urethral Cancer TNM Finding v7)", + "output": "Finding described as a clinical finding about one or more characteristics of urethral cancer, following the rules of the TNM AJCC v7 classification system." + }, + { + "input": "Concept: Abnormality of the bronchi (Anatomical Abnormality)", + "output": "something described as any anomaly of the morphology of the bronchi. []" + }, + { + "input": "Concept: aicardi's syndrome (Atrophy of corpus callosum)", + "output": "Rare Non-Neoplastic Disorder described as a rare genetic disorder characterized by partial or complete absence of the CORPUS CALLOSUM, resulting in infantile spasms, MENTAL RETARDATION, and lesions of the RETINA or OPTIC NERVE." + }, + { + "input": "Concept: collagen type XI location (Cell Component)", + "output": "Cell Component described as a collagen heterotrimer containing type XI alpha chains in alpha1(XI)alpha2(XI)alpha3(XI) trimers; type XI collagen triple helices associate to form fibrils." + }, + { + "input": "Concept: Cell Invasion (Pathologic Function)", + "output": "Pathologic Function described as the movement of one cell type into an area normally occupied by a different cell type." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, TCF4 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication described as molecular assay reagents intended to identify deletions or duplications of the T-box 5 (TBX5) gene, located at chromosome 12q24.21, which encodes the protein T-box transcription factor TBX5. Genetic variants at this locus have been associated with Holt-Oram syndrome." + }, + { + "input": "Concept: Subgingival (Gingival route)", + "output": "Gingival route described as a gingival route that begins beneath the free margin of the gingivae." + }, + { + "input": "Concept: Respiratory Bronchiole (Bronchiolar part of bronchial tree)", + "output": "Body Part, Organ, or Organ Component described as the narrowest airway of the bronchial tree, which is formed by the division of terminal bronchioles, and which contains alveoli along its wall for gas exchange." + }, + { + "input": "Concept: cytolytic granule lumen (cytoplasmic vesicle lumen)", + "output": "Cell Component described as any cytoplasmic membrane-bounded vesicle lumen that is part of a cytolytic granule." + }, + { + "input": "Concept: MMS103C (Intellectual Product)", + "output": "Intellectual Product described as mini-Mental State Examination - Now repeat those words back to me: Word 3." + }, + { + "input": "Concept: Rickettsia rickettsii (Wolbach 1919) Brumpt 1922 (Rickettsia)", + "output": "R [Preparations] described as a species of aerobic, Gram negative, rod and cocci shaped bacteria assigned to the phylum Proteobacteria. This species is obligately intracellular, motile and transmitted to humans by tick hosts, Dermacentor variabilis and Dermacentor andersoni. R. rickettsii is a pathogen that causes Rocky Mountain spotted fever." + }, + { + "input": "Concept: Hemizygotes (Genotype types)", + "output": "GENE-RELATED PHENOMENA described as an individual having only one allele at a given locus because of the loss of the other allele through a mutation (e.g., CHROMOSOME DELETION)." + }, + { + "input": "Concept: Spontaneous Perforation (Acquired Abnormality)", + "output": "Pathological Conditions, Anatomical described as a pathological hole in an organ, blood vessel or other soft part of the body, occurring in the absence of external force." + }, + { + "input": "Concept: Low-Density Lipoprotein Receptor Related Protein 1B (receptor)", + "output": "Amino Acid, Peptide, or Protein described as low-density lipoprotein receptor-related protein 1B (4599 aa, ~515 kDa) is encoded by the human LRP1B gene. This protein plays a role in the metabolism of low density lipoproteins." + }, + { + "input": "Concept: FANCF Gene Mutation (Fanconi Anemia Complementation Group Gene Mutation)", + "output": "Cell or Molecular Dysfunction described as a change in the nucleotide sequence of the FANCF gene." + }, + { + "input": "Concept: Intravesical Cacillus Calmette-Guerin Therapy Failure (Clinical course)", + "output": "Clinical course described as failure to achieve a disease-free state following BCG treatment." + }, + { + "input": "Concept: Ceftibuten Dihydrate (C [Preparations])", + "output": "something described as the dihydrate form of ceftibuten, a semisynthetic, beta-lactamase-stable, third-generation cephalosporin with antibacterial activity. Ceftibuten binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis." + }, + { + "input": "Concept: Subgen:Primate immunodef virus (Subfamily lentivirinae)", + "output": "Subfamily lentivirinae described as a subgenus of LENTIVIRUS comprising viruses that produce immunodeficiencies in primates, including humans." + }, + { + "input": "Concept: Equipment, Personal Protective (Manufactured Object)", + "output": "Manufactured Object described as specialized clothing or equipment worn for protection against health hazards. Personal Protective Equipment may include MASKS; RESPIRATORY PROTECTIVE DEVICES; HEAD PROTECTIVE DEVICES; EYE PROTECTIVE DEVICES; EAR PROTECTIVE DEVICES; PROTECTIVE CLOTHING; and protective footwear." + }, + { + "input": "Concept: Bisbenzyls (Stilbenes)", + "output": "Benzyl Compounds described as compounds that include 1,2-diphenylethane in their structure." + }, + { + "input": "Concept: Walk on Level Surface (Clinical or Research Assessment Question)", + "output": "something described as a question about an individual's ability to walk on a level surface." + }, + { + "input": "Concept: pronase oral solution (Pharmacologic Substance)", + "output": "something described as an oral solution containing a mixture of proteinases, which are produced by Streptomyces griseus, with mucolytic activity and potential diagnostic applications. Upon oral administration, pronase is able to cleave peptide chains of polypeptides into individual amino acids, thereby dissolving mucus. The removal of mucus may improve the visibility of parts of the digestive tract, such as the esophagus and the stomach, during endoscopy. Pre-treatment with pronase before endoscopic examination may help in the detection of certain cancers, such as esophageal and gastric cancer. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C114290\" active clinical trials using this agent." + }, + { + "input": "Concept: Stage IIIC Uterine Corpus Adenosarcoma (Neoplastic Process)", + "output": "something described as stage IIIC includes: T1-3, N1, M0. T1: Uterine corpus adenosarcoma with tumor limited to the uterus. T2: Uterine corpus adenosarcoma with tumor extending beyond the uterus, within the pelvis. T3: Uterine corpus adenosarcoma with tumor infiltrating abdominal tissues. N1: Regional lymph node metastasis. M0: No distant metastasis." + }, + { + "input": "Concept: Products and technology of rural land development (Manufactured Object)", + "output": "something described as products and technology in rural land areas, as they affect an individual's outdoor environment through the implementation of rural land use policies, design, planning and development of space, such as farm lands, pathways and signposting." + }, + { + "input": "Concept: positive regulation of spore-bearing organ development (positive regulation of reproductive process)", + "output": "positive regulation of reproductive process described as any process that activates, maintains or increases the frequency, rate or extent of spore-bearing organ development, a process in which hyphae grow into special aggregates called fruiting bodies that produce new spores." + }, + { + "input": "Concept: 1,1',1\"-phosphinothioylidynetrisaziridine (Organothiophosphorus Compounds)", + "output": "Pharmacologic Substance described as an anticancer drug that belongs to the family of drugs called alkylating agents." + }, + { + "input": "Concept: Nutrition Disorders (Nutrition Disorders)", + "output": "something described as any condition related to a disturbance between proper intake and utilization of nourishment." + }, + { + "input": "Concept: Vena suprarenalis (adrenalis) dextra (Body Part, Organ, or Organ Component)", + "output": "Vena cava structure described as suprarenal vein, each instance of which is a tributary of some inferior vena cava that drains some right suprarenal gland." + }, + { + "input": "Concept: Maintaining vehicles (Daily or Recreational Activity)", + "output": "Daily or Recreational Activity described as repairing and taking care of motorized and non-motorized vehicles for personal use, including bicycles, carts, automobiles and boats." + }, + { + "input": "Concept: Oral Hairy Leukoplakia (White lesion of the oral mucosa)", + "output": "Leukoplakia, Oral described as a corrugated white lesion of the oral mucosa that usually occurs on the lateral or ventral surfaces of the tongue and may have a shaggy or frayed appearance. []" + }, + { + "input": "Concept: Salivary Gland Myoepithelial Tumor (Salivary Gland Neoplasms)", + "output": "Myoepithelioma described as a benign or malignant tumor that arises from the salivary glands. It is characterized by the presence of neoplastic cells with myoepithelial differentiation. This category includes benign myoepithelioma and myoepithelial carcinoma." + }, + { + "input": "Concept: PROTHROMBIN, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)", + "output": "Indicator, Reagent, or Diagnostic Aid described as a prothrombin immunological test system is a device that consists of the reagents used to measure by immunochemical techniques the prothrombin (clotting factor II) in serum. Measurements of the amount of antigenically competent (ability to react with protein antibodies) prothrombin aid in the diagnosis of blood-clotting disorders." + }, + { + "input": "Concept: octopamine secretion (Cell Function)", + "output": "neurotransmitter transport described as the controlled release of octopamine by a cell." + }, + { + "input": "Concept: INPROQUONE (Organic Chemical)", + "output": "Organic Chemical described as a benzoquinone-based antineoplastic agent. Inproquone was never marketed." + }, + { + "input": "Concept: Abnormal presence of protein (Abnormal biochemistry finding)", + "output": "General health described as detection of protein in a location it should not normally be present" + }, + { + "input": "Concept: Basic Behavioral and Social Science Research (Behavioral Research)", + "output": "Behavioral Research described as basic social sciences and behavioral research designed to strengthen the understanding of (a) the determinants and processes that influence HIV-related risk behaviors and (b) the consequences of HIV disease." + }, + { + "input": "Concept: Ecchymoses (skin color and pigmentation)", + "output": "Hemorrhage described as a purpuric lesion that is larger than 1 cm in diameter. []" + }, + { + "input": "Concept: CSS08-Frequency, Write Response (C-SSRS Children's Since Last Visit Questionnaire Question)", + "output": "something described as columbia-Suicidality Severity Rating Scale Children's Since Last Visit (C-SSRS Children's Since Last Visit) Frequency, write response." + }, + { + "input": "Concept: delta-type opioid receptor binding (Molecular Function)", + "output": "something described as interacting selectively and non-covalently with a delta-type opioid receptor." + }, + { + "input": "Concept: Fracture of thigh, NOS (Musculoskeletal)", + "output": "Injury of hip and thigh described as a break or crush injury of the thigh bone (femur). []" + }, + { + "input": "Concept: Mucopolysaccharidosis Is (Connective Tissue Diseases)", + "output": "Enzyme Deficiency described as autosomal recessive systemic lysosomal storage disease caused by a deficiency of alpha-L-iduronidase and characterized by progressive physical deterioration with urinary excretion of dermatan sulfate and heparan sulfate; there are three recognized phenotypes representing a spectrum of clinical severity from severe to mild: Hurler's syndrome, Hurler-Scheie syndrome and Scheie's syndrome (formerly mucopolysaccharidosis V); symptoms may include dwarfism, hepatosplenomegaly, gargoyle-like facies, corneal clouding, cardiac complications, and noisy breathing." + }, + { + "input": "Concept: Gingival pocket (Mass of oral cavity)", + "output": "Gingivitis described as an abnormal deepening of a gingival sulcus not associated with destruction of the supporting periodontal tissue." + }, + { + "input": "Concept: Colonic varices (Disease or Syndrome)", + "output": "Abnormal large intestine morphology described as the presence of varices (enlarged and convoluted blood vessels) in the colon." + }, + { + "input": "Concept: Interrupted inferior vena cava with azygous continuation (Abnormal inferior vena cava morphology)", + "output": "Abnormal inferior vena cava morphology described as interrupted inferior vena cava with azygous continuation is the result of connection failure between the right subcardinal vein and the right vitelline vein. Consequently, venous blood from the caudal part of the body reaches the heart via the azygous vein and superior vena cava." + }, + { + "input": "Concept: Prostaglandin D2 Synthase, Brain Gene (Gene or Genome)", + "output": "Gene or Genome described as human PTGDS wild-type allele is located in the vicinity of 9q34.3 and is approximately 7 kb in length. This allele, which encodes prostaglandin-H2 D-isomerase protein, plays a role in prostaglandin metabolism." + }, + { + "input": "Concept: Grade 3 Serum Sickness, CTCAE (Serum Sickness, CTCAE 3.0)", + "output": "Finding described as severe arthralgia or arthritis; extensive rash; steroids or IV fluids indicated" + }, + { + "input": "Concept: lymphoblastic; lymphoma (High grade T-cell lymphoma)", + "output": "Lymphoma, Diffuse described as a lymphoma composed of immature small to medium-sized precursor lymphoid cells (lymphoblasts). It includes the B- and T-cell lymphoblastic lymphoma." + }, + { + "input": "Concept: Chronic lactic acidosis (METABOLIC FEATURES)", + "output": "Finding described as a chronic form of lactic acidemia." + }, + { + "input": "Concept: Blood Pheresis Sets, Open (Medical Device)", + "output": "Blood Pheresis Sets described as blood pheresis sets in which the components can be attached in-situ, allowing flexibility in the connection and use of intravenous and anticoagulant solutions. These sets typically include tubing, needles, and collection bags. Open blood pheresis sets are simpler and allow more flexibility than closed sets, but the pheresis products can be stored only for several hours. They are used in apheresis units." + }, + { + "input": "Concept: hypovitaminosis (Vitamin Deficiency)", + "output": "Other nutritional deficiency described as condition due to a deficiency of one or more essential vitamins." + }, + { + "input": "Concept: Poly[ADP-Ribose] Synthase 1 (Enzyme)", + "output": "Enzyme described as an enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell actions, UV light, some anticancer drugs, and radiation used to treat cancer. Inhibitors of PARP-1 are being studied in the treatment of cancer." + }, + { + "input": "Concept: acro osteolysis (Bone Diseases, Developmental)", + "output": "something described as a condition with congenital and acquired forms causing recurrent ulcers in the fingers and toes. The congenital form exhibits autosomal dominant inheritance; the acquired form is found in workers who handle VINYL CHLORIDE. When acro-osteolysis is accompanied by generalized OSTEOPOROSIS and skull deformations, it is called HAJDU-CHENEY SYNDROME." + }, + { + "input": "Concept: body posture (Spatial and relational concepts)", + "output": "Movement described as see:http://www.nlm.nih.gov/mesh/MBrowser.html" + }, + { + "input": "Concept: Implants, Single-Tooth (Implantable dental prosthesis, device)", + "output": "Medical Device described as devices, usually alloplastic, surgically inserted into or onto the jawbone, which support a single prosthetic tooth and serve either as abutments or as cosmetic replacements for missing teeth." + }, + { + "input": "Concept: TAA (Antigens)", + "output": "Cancer-related substance, NOS described as 1. antigens that may be frequently associated with tumors or may be specifically found on tumor cells of the same origin (tumor specific); 2. tumor antigens may also be associated with replication and transformation by certain DNA tumor viruses, including adenoviruses and papovaviruses. Neoantigens. Any immunologically detectable marker whose presence or amount indicates the presence of a tumor." + }, + { + "input": "Concept: Cohort Dose (Quantitative Concept)", + "output": "Quantitative Concept described as the dose of medication administered to a particular cohort." + }, + { + "input": "Concept: Arterial Thrombosis Related to Vascular Access Complication (Pathologic Function)", + "output": "Pathologic Function described as the formation of a thrombus in the artery as a direct result of an activity associated with vascular access." + }, + { + "input": "Concept: Indolent Non-Contiguous Stage II Adult Non-Hodgkin's Lymphoma (Ann Arbor Stage II Non-Contiguous Adult Non-Hodgkin Lymphoma)", + "output": "something described as stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C8478\" active clinical trials using this agent." + }, + { + "input": "Concept: VAV3 wt Allele (VAV3 gene)", + "output": "VAV3 gene described as human VAV3 wild type allele is located in the vicinity of 1p13.3 and is approximately 394 kb in length. This allele, which encodes guanine nucleotide exchange factor VAV3 protein, plays a role in the mediation of actin remodeling." + }, + { + "input": "Concept: negative regulation of cardiac muscle cell proliferation (Cell Function)", + "output": "negative regulation of cardiac muscle tissue growth described as any process that stops, prevents, or reduces the frequency, rate or extent of cardiac muscle cell proliferation." + }, + { + "input": "Concept: nature versus nurture (Thesaurus of Psychological Index Terms)", + "output": "Thesaurus of Psychological Index Terms described as debatable issue concerning the controversial role of genetics or heredity versus environment or experience in normal or abnormal developmental processes." + }, + { + "input": "Concept: Grade 5 Neonatal Fever, AE (Finding)", + "output": "something described as a febrile adverse event in a newborn which results in death." + }, + { + "input": "Concept: stage III hypopharynx cancer (Stage III Pharynx Carcinoma)", + "output": "Hypopharyngeal cancer stage NOS described as stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor more than 4 cm in greatest dimension or with fixation of hemilarynx. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis." + }, + { + "input": "Concept: Acne (Acneiform Eruptions)", + "output": "something described as a disorder of the skin in which oil glands and hair glands become inflamed." + }, + { + "input": "Concept: Mimulus guttatus / figwort (Flower Essences)", + "output": "Pharmacologic Substance described as figwort." + }, + { + "input": "Concept: Immunoglobulin Heavy Constant Gamma 4 (Laboratory Procedure)", + "output": "Laboratory Procedure described as a measurement of the immunoglobulin heavy constant gamma 4 in a biological specimen." + }, + { + "input": "Concept: Ferrous sulfate-containing product (iron)", + "output": "F [Preparations] described as a form of the mineral iron that is used to treat anemia caused by low amounts of iron in the blood. Anemia is a condition in which the number of red blood cells is below normal. Ferrous sulfate is a type of hematinic and a type of dietary supplement." + }, + { + "input": "Concept: therapeutic liver cancer peptide vaccine IMA970A (Pharmacologic Substance)", + "output": "Amino Acid, Peptide, or Protein described as an off-the-shelf hepatocellular cancer (HCC) multi-peptide-based therapeutic vaccine composed of sixteen peptides derived from tumor-associated antigens (TAAs) expressed by hepatic tumor cells, of which seven are restricted to human leukocyte antigen (HLA)-A2 (HLA-A*02), five to HLA-A*24 and four to HLA class II, with potential immunomodulating and antineoplastic activities. Upon intradermal administration of the therapeutic liver cancer peptide vaccine IMA970A, the liver-specific peptides in the vaccine activate the immune system to exert both CD4+ T-helper and CD8+ cytotoxic T-lymphocyte (CTL)-mediated immune responses against liver cancer cells." + }, + { + "input": "Concept: How Useful Numerical Information (Intellectual Product)", + "output": "Findings-Based Question described as a question about how useful an individual finds or found numerical information." + }, + { + "input": "Concept: Stage IVC Thyroid Gland Medullary Cancer (Neoplastic Process)", + "output": "something described as stage IVC includes: Any T, Any N, M1. M1: Distant metastasis." + }, + { + "input": "Concept: CDP synthesis (pyrimidine ribonucleotide biosynthetic process)", + "output": "CDP metabolic process described as the chemical reactions and pathways resulting in the formation of CDP, cytidine (5'-)diphosphate." + }, + { + "input": "Concept: Regulator of G-Protein Signalling 5 wt Allele (Gene or Genome)", + "output": "something described as human RGS5 wild-type allele is located in the vicinity of 1q23.1 and is approximately 75 kb in length. This allele, which encodes regulator of G-protein signaling 5 protein, is involved in the modulation of heterotrimeric G-protein-mediated signal transduction. Aberrant expression may play a role in tumor angiogenesis." + }, + { + "input": "Concept: hospital accreditation (Governmental or Regulatory Activity)", + "output": "Governmental or Regulatory Activity described as recognition of a hospital as maintaining standards set by a government agency." + }, + { + "input": "Concept: Conspicuously happy disposition (Finding)", + "output": "something described as an unusually happy aspect over time which can also may be observed during inappropriate situations that should be causing for example distress, fear or anger." + }, + { + "input": "Concept: Tumors, Placental-Site Trophoblastic (Neoplastic Process)", + "output": "Deciduoma described as a rare gestational trophoblastic tumor characterized by the presence of a diffuse cellular infiltrate composed of intermediate trophoblasts and cytotrophoblasts and by the absense of a significant population of syncytiotrophoblasts." + }, + { + "input": "Concept: TARGET OF METHYLATION-INDUCED SILENCING 1 (Gene or Genome)", + "output": "Apoptosis Promoter Gene described as this gene plays a role in the regulation of apoptosis." + }, + { + "input": "Concept: Prostate Tissue Pathology Slide Computer-Aided Detection Systems (Medical Device)", + "output": "Medical Device described as computer-aided detection systems that analyze digital information (typically digital images) from prostate tissue histologic slides to detect abnormalities. They may either digitize the original information or use information provided by digital systems. These systems typically consist of a digitizer or a means to import digital information, a computer capable of using appropriate algorithms, and a display and/or printer to show the detected abnormalities in prostate tissue. Some systems may include capabilities of archiving and/or communication of view and annotated digital images of pathology scanned slides. Prostate tissue computer-aided detection systems are used for prostate cancer screening and in combination with molecular markers and clinical patient data to aid in the prediction of prostate cancer recurrence." + }, + { + "input": "Concept: brand names (Product name type messages)", + "output": "Intellectual Product described as proprietary Name" + }, + { + "input": "Concept: regulation of physiological defense response to insect (regulation of defense response)", + "output": "regulation of defense response described as any process that modulates the frequency, rate or extent of defense response to insect." + }, + { + "input": "Concept: out ruling (Frequency)", + "output": "Frequency described as present in 0% of the cases. []" + }, + { + "input": "Concept: chronic lung disease of babies (Disease or Syndrome)", + "output": "Disease or Syndrome described as chronic lung disease requiring treatment with oxygen for at least 28 days and with a spectrum of severity from mild to severe, that predominantly affects premature infants. While the radiologic pattern is typical in the closer to term patient, the pattern in the small preterm infant is very non-discrete and variable." + }, + { + "input": "Concept: Abnormally low T cell receptor excision circle level (Abnormal T cell count)", + "output": "Abnormal T cell count described as reduced level of T cell receptor excision circle (TRECs) as measured by the TREC assay. Late in maturation, 70% of thymocytes that will ultimately express alpha/beta-T cell receptors form a circular DNA TREC from the excised TCRdelta gene that lies within the TCRalpha genetic locus. The circles are stable but do not increase following cell division and, therefore, become diluted as T cells proliferate. A quantitative polymerase chain reaction (PCR) reaction across the joint of the circular DNA provides the TREC copy number, a marker of newly-formed, antigenically-nave thymic emigrant T cells." + }, + { + "input": "Concept: Neurotoxicology (Organism Function)", + "output": "something described as science concerned with the detection, chemical composition, and biological action of toxic substances or poisons in the nervous system and the treatment and prevention of toxic manifestations in the nervous system; for intended, desired effects of drugs or agents see NEUROPHARMACOLOGY." + }, + { + "input": "Concept: L/day/umol (Quantitative Concept)", + "output": "something described as liters per micromole per day." + }, + { + "input": "Concept: regulation of erythrocyte differentiation (Cell Function)", + "output": "Cell Function described as any process that modulates the frequency, rate or extent of erythrocyte differentiation." + }, + { + "input": "Concept: Countershock, Electric (Electric Stimulation Therapy)", + "output": "Cardiac therapeutic procedures described as an electrical current applied to the HEART to terminate a CARDIAC ARRHYTHMIA." + }, + { + "input": "Concept: signal transduction pathway (Biochemical Pathway)", + "output": "something described as describes a group of molecules in a cell that work together to control one or more cell functions, such as cell division or cell death. After the first molecule in a pathway receives a signal, it activates another molecule. This process is repeated until the last molecule is activated and the cell function involved is carried out. Abnormal activation of signaling pathways can lead to cancer, and drugs are being developed to block these pathways. This may help block cancer cell growth and kill cancer cells." + }, + { + "input": "Concept: Loss of Chromosome 10p (Cell or Molecular Dysfunction)", + "output": "Cell or Molecular Dysfunction described as a cytogenetic abnormality that refers to the loss of all or part of the short arm of chromosome 10 (10p)." + }, + { + "input": "Concept: PAIRING (Nonclinical Trial Phase)", + "output": "Nonclinical Trial Phase described as the period of time in a non-clinical study from the start of cohabitation until evidence of mating is observed and/or the subjects are separated." + }, + { + "input": "Concept: Allergic Angina Syndrome (Ischaemic coronary artery disorders)", + "output": "Ischaemic coronary artery disorders described as a disorder of cardiac function secondary to hypersensitivity reactions. It is characterized by coexistence of acute coronary syndromes and cardiac MAST CELL and PLATELET ACTIVATION. It may be induced by exposure to drugs (e.g., antibiotics, anesthetics, contrast media), food, and environmental triggers (e.g., insect bites and stings, poison ivy)." + }, + { + "input": "Concept: ATR-16 SYNDROME (Intellectual Disability)", + "output": "Mental Retardation described as a variant of the alpha-thalassemia/mental retardation syndrome (ATR) due to deletion of a segment of the short arm of chromosome 16. A form in which there is no deletion is termed \"alpha-thalassemia/mental retardation syndrome, nondeletion type\" (q.v.). The phenotype is variable and consists of mental retardation in association with different combinations of oro-facial, genital, and other abnormalities." + }, + { + "input": "Concept: Resectable Oropharyngeal Squamous Cell Carcinoma (Neoplastic Process)", + "output": "Neoplastic Process described as oropharyngeal squamous cell carcinoma that is amenable to surgical resection." + }, + { + "input": "Concept: Proteins, Antifreeze (Biologically Active Substance)", + "output": "Biologically Active Substance described as proteins that bind to ice and modify the growth of ice crystals. They perform a cryoprotective role in a variety of organisms." + }, + { + "input": "Concept: Information Dissemination (Social Behavior)", + "output": "something described as for information to be useful, not only does it need to be made available at the right time to those who need it such as policy makers, program planners, and health professionals, and patients but it has to be in the right form. Information Dissemination includes both research into means of information distribution and the actual distribution of information." + }, + { + "input": "Concept: hypnotism (Alternative Therapies)", + "output": "Disturbance of consciousness described as a state of increased receptivity to suggestion and direction, initially induced by the influence of another person." + }, + { + "input": "Concept: GEMELLA MORBILLORUM (Streptococcus)", + "output": "something described as any bacterial organism that can be assigned to the species Gemella morbillorum." + }, + { + "input": "Concept: gibberellin biosynthetic process (gibberellin metabolic process)", + "output": "carboxylic acid biosynthetic process described as the chemical reactions and pathways resulting in the formation of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators." + }, + { + "input": "Concept: Metabolic Brain Syndrome, Acquired (Disease or Syndrome)", + "output": "something described as brain dysfunction or damage caused by acquired (i.e., non-inborn) metabolic disorders. Associated conditions include ENDOCRINE DISEASES; WATER-ELECTROLYTE IMBALANCE; KIDNEY DISEASES; LIVER DISEASES; anoxia (HYPOXIA, BRAIN); nutritional disorders (see NUTRITIONAL AND METABOLIC DISEASES); an encephalopathy associated with HEMODIALYSIS; and other disorders." + }, + { + "input": "Concept: Cilium, NOS (membrane prolongation)", + "output": "Cellular Structures described as an organelle that protrudes outward from the cell body. It consists of a specialized arrangement of 9 doublet microtubules in a ring with or without a core of 2 microtubules and is enclosed in a plasma membrane coat. Motile cilia contain the motor protein dynein." + }, + { + "input": "Concept: Postorgasmic illness syndrome (Male coital disorder)", + "output": "Male coital disorder described as a rare urogenital disease characterised by the appearance of flu-like symptoms (fever, extreme fatigue, myalgia, itchy burning eyes, nasal congestion/rhinorrhoea), as well as mood changes, irritability and concentration, memory and attention difficulties, within a few minutes to a few hours after ejaculation. Symptoms disappear spontaneously 3-7 days after onset." + }, + { + "input": "Concept: Low risk (Quantitative Concept)", + "output": "Quantitative Concept described as the potential future harm that may arise from some present action or attribute or condition is small." + }, + { + "input": "Concept: One cane or crutch used most of the time (Intellectual Product)", + "output": "Clinical or Research Assessment Answer described as a response indicating that a person requires use of one cane or crutch most of the time." + }, + { + "input": "Concept: Mild nonproliferative retinopathy (Visually threatening diabetic retinopathy)", + "output": "Disease or Syndrome described as microaneurysms only" + }, + { + "input": "Concept: Fatigue Interferes with General Activity (Intellectual Product)", + "output": "Findings-Based Question described as a question about how an individual's fatigue interfered or interferes with their general activity." + }, + { + "input": "Concept: FAC036-Can Swallow Naturally and Easily (NCCN-FACT FHNSI-22 Version 2 Questionnaire Question)", + "output": "something described as national Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Head & Neck Symptom Index-22 Version 2 - I can swallow naturally and easily." + }, + { + "input": "Concept: ASK (non-infectious skin disorders)", + "output": "Keratosis described as a hyperkeratotic skin lesion that occurs in patients who have been exposed to arsenic." + }, + { + "input": "Concept: TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY, MEMBER 18 (tumor necrosis factor family gene)", + "output": "tumor necrosis factor family gene described as this gene plays a role in the modulation of T-cell activation and proliferation." + }, + { + "input": "Concept: CONFORMAL RADIOTHER (Therapeutic or Preventive Procedure)", + "output": "cancer treatment described as a therapy using IONIZING RADIATION where there is improved dose homogeneity within the tumor and reduced dosage to uninvolved structures. The precise shaping of dose distribution is achieved via the use of computer-controlled multileaf collimators." + }, + { + "input": "Concept: Autosomal recessive spastic paraplegia type 25 (Complicated hereditary spastic paraplegia)", + "output": "Autosomal recessive hereditary disorder described as a rare complex type of hereditary spastic paraplegia with characteristics of adult-onset spastic paraplegia associated with spinal pain that radiates to the upper or lower limbs and is related to disk herniation (with minor spondylosis), as well as mild sensorimotor neuropathy. The phenotype has been mapped to a locus on chromosome 6q23-q24.1." + }, + { + "input": "Concept: Grade 1 Intraoperative endocrine injury (Intraoperative Endocrine Injury, CTCAE)", + "output": "Intraoperative Endocrine Injury, CTCAE described as primary repair of injured organ/structure indicated" + }, + { + "input": "Concept: genetically-modified MAGE-A3-expressing MG1 Maraba virus vaccine (Cancer Vaccines)", + "output": "something described as a vaccine consisting of the attenuated, genetically-modified, oncolytic form of the Maraba virus, MG1, which has been engineered to express a gene encoding the cancer testis antigen melanoma antigen family A3 (MAGE-A3), with potential antineoplastic activity. Upon administration of genetically-modified MAGE-A3-expressing MG1 Maraba virus vaccine, the attenuated Maraba virus selectively and rapidly replicates in cancer cells; however, it is unable to replicate in normal, healthy cells. This induces a selective Maraba virus-mediated cytotoxicity in those cancer cells, and leads to cancer cell lysis. In addition, the expression of MAGE-A3 further stimulates the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing MAGE-A3. The tumor-associated antigen MAGE-A3 is overexpressed by a variety of cancer cell types. The attenuated virus is a double mutant strain with single amino acid substitutions occurring in both G protein (Q242R) and M protein (L123W). Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C118973\" active clinical trials using this agent." + }, + { + "input": "Concept: Cytochrome P450, Subfamily VIIA (Cholesterol 7 Alpha-Monooxygenase), Polypeptide 1 (Cytochrome P450)", + "output": "something described as cholesterol 7-alpha-monooxygenase (504 aa, ~58 kDa) is encoded by the human CYP7A1 gene. This protein plays a role in both cholesterol catabolism and bile acid biosynthesis." + }, + { + "input": "Concept: sucrose-UDP glucosyltransferase activity (Molecular Function)", + "output": "something described as catalysis of the reaction: UDP-glucose + D-fructose = UDP + sucrose." + }, + { + "input": "Concept: Healthy Subject Indicator (Indicator)", + "output": "Qualitative Concept described as indicate if persons who have not had the condition(s) being studied or otherwise related conditions or symptoms, as specified in the eligibility requirements, may participate in the study." + }, + { + "input": "Concept: gamma-Atrial Natriuretic Peptide (Biologically Active Substance)", + "output": "Biologically Active Substance described as the 126-amino acid C-terminal fragment of the ANP precursor, an approximately 150-amino acid polypeptide in a number of species. It is formed by the removal of the N-terminal signal sequence ANP (1-24). This prohormone contains various active ANF sequences." + }, + { + "input": "Concept: Product containing sulfuric acid (Strong acid)", + "output": "Corrosive mineral acid described as a strong acid that, when concentrated is extremely corrosive to the skin and mucous membranes. It is used in making fertilizers, dyes, electroplating, and industrial explosives." + }, + { + "input": "Concept: PQL1516 (Intellectual Product)", + "output": "PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Child Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Acute Version 3 Child Parent Report - In the past 7 days, how much of a problem has this been for your child: It is hard for my child to turn him or herself during the night." + }, + { + "input": "Concept: mucuna pruriens/dolichos pru (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as cowhage." + }, + { + "input": "Concept: Platelet glycoprotein GPIIb-IIIa complex (Receptors, Cytoadhesin)", + "output": "Platelet Membrane Glycoproteins described as integrin alpha-IIb/beta3 is a protein complex comprised of a heterodimer of integrin alpha 2b and integrin beta 3. This complex is involved in cell adhesion and blood clot formation." + }, + { + "input": "Concept: Dialister micraerophilus (Dialister)", + "output": "Dialister described as a species of Gram-negative, non-motile, non-sporulating, rod-shaped bacteria in the family Veillonellaceae. D. micraerophilus is generally anaerobic but will also grow under microaerophilic conditions. It can be differentiated from other Dialister species by phenylalanine arylamidase activity and tyrosine arylamidase activity." + }, + { + "input": "Concept: Ampulla of Vater Undifferentiated Carcinoma with Osteoclast-Like Giant Cells (Ampulla of Vater Undifferentiated Carcinoma)", + "output": "Ampulla of Vater Undifferentiated Carcinoma described as a rare variant of undifferentiated carcinoma that arises from the ampulla of Vater. It is characterized by the presence of non-neoplastic, histiocytic, osteoclast-like multinucleated giant cells." + }, + { + "input": "Concept: Gowns, Patient, Disposable (Gowns, Patient)", + "output": "Gowns, Patient described as disposable patient gowns are designed to be worn once and then discarded. These gowns are worn instead of clothing by patients in doctors' offices, hospitals, and other healthcare facilities. Disposable patient gowns are usually loose-fitting, light-weight, short-sleeved, thigh-length garments made of non-woven materials such as paper and plastics. They are intended to facilite easy access to the patients during examinations and medical procedures. These gowns are available in various sizes for men, women, and children. Most gowns have tie closures in either the front or back. Disposable patient gowns are available in many different styles and lengths, depending on their intended use; disposable patient gowns specifically designed for radiographic, mammographic, and gynecological procedures are also available." + }, + { + "input": "Concept: 3-Oxa-9-azoniatricyclo(3.3.1.02,4)nonane, 9-butyl-7-(3-hydroxy-1-oxo-2-phenylpropoxy)-9-methyl-, bromide, (7(S)-(1alpha,2beta,4beta,5alpha,7beta))- (scopolamine)", + "output": "something described as antimuscarinic quaternary ammonium derivative of scopolamine used to treat cramps in gastrointestinal, urinary, uterine, and biliary tracts, and to facilitate radiologic visualization of the gastrointestinal tract." + }, + { + "input": "Concept: Leukonychia totalis (Finding)", + "output": "Dystrophia unguium described as a rare nail anomaly disorder characterised by complete white discolouration of the nails. Patients typically present white, chalky nails as an isolated finding, although other cutaneous or systemic manifestations could also be present. There is evidence the disease can be caused by homozygous or heterozygous mutation in the PLCD1 gene on chromosome 3p22-p21.3." + }, + { + "input": "Concept: MCF7 (Cell Line, Tumor)", + "output": "Cell Line, Tumor described as an adenocarcinoma cell line established in 1970 from the pleural effusion of a 69 year old Caucasian female patient with breast carcinoma." + }, + { + "input": "Concept: Structure of splenic artery (Vascular structure of spleen)", + "output": "something described as an artery arising from the celiac trunk with four main branches that supply the spleen, stomach and pancreas." + }, + { + "input": "Concept: Unresectable Craniopharyngioma (Neoplastic Process)", + "output": "Craniopharyngioma described as a craniopharyngioma that is not amenable to surgical resection." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, RRM2B (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)", + "output": "something described as molecular assay reagents intended to identify deletions or duplications of the ribonucleotide reductase regulatory TP53 inducible subunit M2B (RRM2B) gene, located at chromosome 8q22.3, which encodes the protein ribonucleoside-diphosphate reductase subunit M2 B. Genetic variants at this locus have been associated with progressive external ophthalmoplegia with mitochondrial DNA deletions and mitochondrial DNA depletion syndrome." + }, + { + "input": "Concept: CONNECTOR, CATHETER (Medical Device)", + "output": "something described as an introduction/drainage catheter is a device that is a flexible single or multilumen tube intended to be used to introduce nondrug fluids into body cavities other than blood vessels, drain fluids from body cavities, or evaluate certain physiologic conditions. Examples include irrigation and drainage catheters, pediatric catheters, peritoneal catheters (including dialysis), and other general surgical catheters. An introduction/drainage catheter accessory is intended to aid in the manipulation of or insertion of the device into the body. Examples of accessories include adaptors, connectors, and catheter needles." + }, + { + "input": "Concept: TH (Body Part, Organ, or Organ Component)", + "output": "Body Part, Organ, or Organ Component described as an area on the ventral surface of the temporal lobe of the macaque that is defined on the basis of cytoarchitecture. It is very similar to area TF of Boning-1947 differing only in that its internal pyramidal layer (V) is more dense. The authors regarded it as homologous to the human area TH of Economo-1929 ( Bonin-1947 )." + }, + { + "input": "Concept: Outer Mitochondrial Membrane (Mitochondrial Membranes)", + "output": "organelle outer membrane described as the outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." + }, + { + "input": "Concept: Helical Interpolation Artifact (CT Image Artifact)", + "output": "Finding described as a shape distortion in the z-axis resulting from the weighting function used in the helical interpolation algorithm." + }, + { + "input": "Concept: Tatton Brown Rahman overgrowth syndrome (Intellectual Disability)", + "output": "Multiple malformation syndrome with facial defects as major feature described as a disease associated with faster than normal growth before and after birth, intellectual disability, characteristic facial features including round face, thick horizontal eyebrows, narrowed palpebral fissures. Macrocephaly may also be present along with features of autism spectrum disorder. Other associated signs include kyphoscoliosis, heart defects, pes planus, hypotonia, hypermobile joints depression, anxiety, obsessive-compulsive disorder. Caused by mutation in the DNMT3A gene, which provides instructions for making the enzyme DNA methyltransferase 3 alpha. This condition is inherited in an autosomal dominant pattern, however some cases result from new mutations in the gene and occur in people with no history of the disorder in their family." + }, + { + "input": "Concept: Calcium-Activated Protease (Peptide Hydrolases)", + "output": "caspase described as an intracellular, non-lysosomal enzyme." + }, + { + "input": "Concept: Docetaxel-Gemcitabine Regimen (Therapeutic or Preventive Procedure)", + "output": "something described as a regimen consisting of docetaxel and gemcitabine used to treat advanced-stage non-small cell lung cancer." + }, + { + "input": "Concept: L-ascorbic acid (vitamin C products, plain)", + "output": "Water-soluble vitamin-containing product described as a six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant." + }, + { + "input": "Concept: FLJ21935 (EPS8L2 gene)", + "output": "EPS8L2 gene described as human EPS8L2 wild-type allele is located in the vicinity of 11p15.5 and is approximately 22 kb in length. This allele, which encodes epidermal growth factor receptor kinase substrate 8-like protein 2, plays a role in signal transduction related to actin remodeling." + }, + { + "input": "Concept: subclasses (Classification)", + "output": "Class described as a taxonomic subdivisions more specific than class but more general than order." + }, + { + "input": "Concept: Pro-Caspase-3 (Amino Acid, Peptide, or Protein)", + "output": "something described as caspase-3 (277 aa, ~31 kDa) is encoded by the human CASP3 gene. This protein is involved in the mediation of proteolysis and the activation of apoptosis." + }, + { + "input": "Concept: Pleural (Respiratory site descriptor)", + "output": "something described as of or pertaining to the pleura." + }, + { + "input": "Concept: FAACT (Clinical or Research Assessment Questionnaire)", + "output": "Intellectual Product described as a questionnaire used to assess general aspects of quality of life related to anorexia and cachexia." + }, + { + "input": "Concept: UDP glucose-DNA beta-glucosyltransferase activity (Genetic Function)", + "output": "catalytic activity, acting on DNA described as catalysis of the transfer of a beta-D-glucosyl residue from UDP-glucose to a hydroxymethylcytosine residue in DNA." + }, + { + "input": "Concept: DYSTONIA 16 (Autosomal recessive hereditary disorder)", + "output": "Disease or Syndrome described as an extremely rare autosomal recessive dystonia-parkinsonism condition caused by mutation(s) in the PRKRA gene encoding interferon-inducible double-stranded RNA-dependent protein kinase activator A." + }, + { + "input": "Concept: Quillaja Saponin (Saponins)", + "output": "something described as natural detergents made up of a heterogeneous mixture of molecules having a triterpenoid core structure. They vary in aglycone (sapogenin) and sugar moieties, including glucose." + }, + { + "input": "Concept: bis(molybdopterin guanine dinucleotide)molybdenum metabolism (Nucleotide Metabolism)", + "output": "Nucleotide Metabolism described as the chemical reactions and pathways involving bis(molybdopterin guanine dinucleotide)molybdenum." + }, + { + "input": "Concept: downregulation of protein AMPylation (negative regulation of protein modification process)", + "output": "Molecular Function described as any process that stops, prevents or reduces the frequency, rate or extent of protein adenylylation." + }, + { + "input": "Concept: Low Absorption Retic/Reticulocytes (Laboratory Procedure)", + "output": "something described as the determination of the ratio of low absorption reticulocytes compared to total reticulocytes present in a sample. The measurement may be expressed as a ratio or percentage." + }, + { + "input": "Concept: RecQ Protein-Like 3 Protein Variant (Gene Product Sequence Variation)", + "output": "Cell or Molecular Dysfunction described as a variation in the amino acid sequence for Bloom syndrome protein." + }, + { + "input": "Concept: Miyagawanella ornithosis virus (Chlamydia)", + "output": "Chlamydophila described as bacteria in the genus of Chlamydophila infecting primarily birds; contains eight known serovars, some of which infect more than one type of host, including humans." + }, + { + "input": "Concept: LEC-5 Standard Version - Sexual Assault: Witnessed (LEC-5 Standard Version Questionnaire Question)", + "output": "something described as life Events Checklist for DSM-5, Standard Version - Sexual assault (rape, attempted rape, made to perform any type of sexual act through force or threat of harm): Witnessed it." + }, + { + "input": "Concept: Butane-1,4-Diamine (Cadaverine)", + "output": "BILIRUBIN COMPOUNDS AND BILE ACIDS described as a four carbon diamine produced during tissue decomposition by the decarboxylation of amino acids. Polyamines, including putrescine, may act as growth factors that promote cell division; however, putrescine is toxic at high doses." + }, + { + "input": "Concept: Low-Fat Diets (Fat diet)", + "output": "diet macronutrient percentages or amounts described as a diet that contains limited amounts of fat with less than 30% of calories from all fats and less than 10% from saturated fat. Such a diet is used in control of HYPERLIPIDEMIAS." + }, + { + "input": "Concept: RAD51C gene (FA Complementation Group Gene)", + "output": "RAD51 Family Gene described as this gene plays a role in DNA repair and meiotic recombination." + }, + { + "input": "Concept: Proteus inconstans, subgroup B (Providencia)", + "output": "Providencia described as a species of aerobic, Gram negative, rod shaped bacteria in the phylum Proteobacteria. This species is motile, produces acid from galactose, adonitol, inositol, and trehalose. P. stuartii is an opportunistic pathogen found in multiple animal reservoirs, soil, water, and sewage that can cause catheterization related urinary tract infections or diarrhea." + }, + { + "input": "Concept: 6-hydroxyhexanoate dehydrogenase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the reaction: 6-hydroxyhexanoate + NAD(+) = 6-oxohexanoate + H(+) + NADH." + }, + { + "input": "Concept: GLOBB1BP (Laboratory Procedure)", + "output": "something described as the determination of the ratio of beta-1 globulin compared to beta protein present in a sample. The measurement may be expressed as a ratio or percentage." + }, + { + "input": "Concept: positive regulation of corticosterone secretion (positive regulation of glucocorticoid secretion)", + "output": "something described as any process that activates or increases the frequency, rate or extent of corticosterone secretion." + }, + { + "input": "Concept: Locally Advanced Malignant Peripheral Nerve Sheath Tumor (Neoplastic Process)", + "output": "something described as a malignant peripheral nerve sheath tumor that has spread from its original site of growth to nearby tissues or lymph nodes." + }, + { + "input": "Concept: BPI1-Meds not Prescribed Taken for Pain (BPI Questionnaire Question)", + "output": "BPI Questionnaire Question described as brief Pain Inventory - Medications not prescribed by my doctor that I take for pain are." + }, + { + "input": "Concept: TUCOTUZUMAB CELMOLEUKIN (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as a recombinant fusion protein comprised of a human monoclonal antibody directed against the epithelial cell adhesion molecule (EpCAM or KS) linked to an active interleukin-2 (IL2) molecule with potential antineoplastic activity. The humanized monoclonal antibody moiety of tucotuzumab celmoleukin recognizes and binds to EpCAM, a cell surface epithelial protein that is expressed on a wide variety of cancer cells, thereby concentrating IL2 in EpCAM-expressing tumor tissue. Subsequently, the localized IL2 moiety of this fusion protein may stimulate a cytotoxic T-cell antitumor immune response. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2630\" active clinical trials using this agent." + }, + { + "input": "Concept: Methacin (Quaternary Ammonium Compounds)", + "output": "Anticholinergic Agents described as a quaternary ammonium anticholinergic agent with peripheral side effects similar to those of ATROPINE. It is used as an adjunct in the treatment of gastric and duodenal ulcer, and to relieve visceral spasms. The drug has also been used in the form of eye drops for mydriatic effect." + }, + { + "input": "Concept: Structure of pelvic viscus (Structure of viscus)", + "output": "Entire viscus described as viscus in the pelvis (contained in the pelvic cavity). Examples: uterus, bladder, ovary" + }, + { + "input": "Concept: Abnormality of the duodenum (Anatomical Abnormality)", + "output": "Abnormality of the small intestine described as an abnormality of the duodenum, i.e., the first section of the small intestine." + }, + { + "input": "Concept: Nervous System Findings Test Name (CDISC SDTM Terminology)", + "output": "something described as terminology relevant to the test names that describe nervous system physiology findings." + }, + { + "input": "Concept: response to organic nitrogen (response to organic substance)", + "output": "Cell Function described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond." + }, + { + "input": "Concept: Iwo Jiman race (Population Group)", + "output": "Asians described as a person having origins in any of the original peoples of Iwo Jima." + }, + { + "input": "Concept: MF - Mycosis fungoides (Lymphoma)", + "output": "Other malignant neoplasms of lymphoid and histiocytic tissue described as a chronic, malignant T-cell lymphoma of the skin. In the late stages, the LYMPH NODES and viscera are affected." + }, + { + "input": "Concept: Abnormality of the ductus choledochus (Anatomical Abnormality)", + "output": "something described as an abnormality of the Common bile duct, a tube-like anatomic structure in the human gastrointestinal tract, formed by the union of the Common hepatic duct and the Cystic duct from the gall bladder." + }, + { + "input": "Concept: Doze Off or Fall Asleep (Intellectual Product)", + "output": "Intellectual Product described as a question about an individuals likelihood to doze or fall asleep." + }, + { + "input": "Concept: Linear Regression (Intellectual Product)", + "output": "Body Surface Area Formula described as the formula to calculate body surface area as described by John D. Current. It is mathematically defined as: BSA (m^2) = 1321 + 0.3433 x Weight" + }, + { + "input": "Concept: Ventral Prostate Gland (Body Part, Organ, or Organ Component)", + "output": "something described as a lobe of the prostate gland located on the ventral aspect of the proximal urethra." + }, + { + "input": "Concept: Ball (Manufactured Object)", + "output": "Device Component or Accessory described as any device that is spherical in shape." + }, + { + "input": "Concept: Cryptogenic (Pathologic Processes)", + "output": "General Qualifier described as describes a disease of unknown cause." + }, + { + "input": "Concept: Appendage Carcinoma, Skin (Carcinoma, Skin Appendage)", + "output": "Neoplastic Process described as a carcinoma arising from the sebaceous glands, sweat glands, or the hair follicles. Representative examples include sebaceous carcinoma, apocrine carcinoma, eccrine carcinoma, and pilomatrical carcinoma." + }, + { + "input": "Concept: BONE, FEMUR (Regional site descriptor)", + "output": "Bone structure of pelvic region and/or thigh described as long bone, each instance of which articulates with some hip bone, patella and tibia." + }, + { + "input": "Concept: Scandentia (Eutheria)", + "output": "Mammals described as mammalian order containing the one family of tree shrews; this family, Tupaiidae, in some classification systems is included under O Insectivora or O Primates." + }, + { + "input": "Concept: Polyalthias (Annonaceae)", + "output": "Annonaceae described as a plant genus of the family ANNONACEAE. Members contain 8-oxopolyalthiaine." + }, + { + "input": "Concept: term (Linguistic Form)", + "output": "something described as a word or expression used for some particular thing." + }, + { + "input": "Concept: Donor breastmilk intake (Nutrient Intake)", + "output": "Quantitative Concept described as intake of human milk expressed from a woman's breast to feed an infant that is not the donor's infant." + }, + { + "input": "Concept: BCD-135 (Anti-PD-L1 Monoclonal Antibody)", + "output": "Antineoplastic Antibody described as a monoclonal antibody directed against the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-PD-L1 monoclonal antibody BCD-135 specifically targets and binds to PD-L1, blocking its binding to and activation of its receptor programmed death 1 (PD-1). This reverses T-cell inactivation caused by PD-1/PD-L1 signaling and enhances the cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response against PD-L1-expressing tumor cells. PD-L1 is overexpressed by many human cancer cell types. PD-L1 binding to PD-1 on T-cells suppresses the immune system and results in immune evasion. PD-1, a transmembrane protein belonging to the immunoglobulin superfamily expressed on activated T-cells, is a negative regulator of the immune system that limits the expansion and survival of CD8-positive T-cells." + }, + { + "input": "Concept: Surgery specialty (Medical Specialities)", + "output": "Specialty Type described as the branch of medical science that treats disease or injury by operative procedures." + }, + { + "input": "Concept: Were you short of breath when you rested (Clinical or Research Assessment Question)", + "output": "Clinical or Research Assessment Question described as a question about whether an individual is or was short of breath when they rested." + }, + { + "input": "Concept: AST raised (Liver Function Tests)", + "output": "Elevated hepatic transaminase described as an abnormally high concentration in the circulation of aspartate aminotransferase (AST). []" + }, + { + "input": "Concept: Abnormality of the glenoid fossa (Abnormality of the shoulder)", + "output": "Anatomical Abnormality described as an anomaly of the glenoid fossa, also known as the glenoid cavity, which is the articular surface of the scapula that articulates with the head of the humerus." + }, + { + "input": "Concept: Vein of thorax (Veins)", + "output": "Body Part, Organ, or Organ Component described as either of two veins including the internal and lateral thoracic veins that drain the breasts and chest wall." + }, + { + "input": "Concept: Neutraceutical (Food)", + "output": "something described as a food or dietary supplement that is believed to provide health benefits." + }, + { + "input": "Concept: Deleterious LFS2 Gene Mutation (Checkpoint kinase 2 gene mutation)", + "output": "Cell or Molecular Dysfunction described as a change in the nucleotide sequence of the CHEK2 gene that is associated with increased risk of disease." + }, + { + "input": "Concept: Multinodular and Vacuolated Pattern (Morphologic Architectural Pattern)", + "output": "something described as an architectural pattern characterized by the presence of neoplastic cells forming multiple nodules with prominent vacuolation." + }, + { + "input": "Concept: Haemosiderosis NOS (Nutritional and Metabolic Diseases)", + "output": "Disease or Syndrome described as conditions in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the reticuloendothelial system, without demonstrable tissue damage." + }, + { + "input": "Concept: PQL1014 (Intellectual Product)", + "output": "Intellectual Product described as pediatric Quality of Life Neuromuscular Module Acute Version 3.0 Young Adult Report (PedsQL Neuromuscular Module Acute Version 3.0 Young Adult Report) In the past 7 days, how much of a problem has this been for you: I get hurt accidentally." + }, + { + "input": "Concept: Glucose Clearance Measurement (Laboratory Procedure)", + "output": "Chemical procedure described as a measurement of the glucose clearance in a sample." + }, + { + "input": "Concept: cysteine (sulfite) lyase activity (carbon-sulfur lyase activity)", + "output": "carbon-sulfur lyase activity described as catalysis of the reaction: L-cysteine + sulfite = L-cysteate + sulfide." + }, + { + "input": "Concept: Susceptible (Laboratory or Test Result)", + "output": "something described as a microbial susceptibility test result in which the growth of microorganisms is inhibited by the usually achievable concentrations of antimicrobial agent when the recommended dosage is used for the site of infection." + }, + { + "input": "Concept: Acropectorovertebral Dysplasia, F-Form (Hereditary Connective Tissue Disorder)", + "output": "Finding of vertebra described as a skeletal dysplasia with characteristics of fusion of the carpal and tarsal bones and complex anomalies of the fingers and toes. It has been described in less than 30 patients from three unrelated families. Other manifestations include prominence of the sternum with variable pectus excavatum, lumbosacral spina bifida occulta, minor craniofacial anomalies and mild intellectual deficit. This syndrome is transmitted as an autosomal dominant trait with full penetrance. The causative gene has been mapped to chromosome region 2q36." + }, + { + "input": "Concept: cell adhesion involved in retrograde extension (Cell Adhesion)", + "output": "Cell Function described as the attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension." + }, + { + "input": "Concept: Piritrexim Isethionate (Dihydrofolate Reductase Inhibitors)", + "output": "something described as the isethionate salt of piritrexim, a synthetic antifolate agent with antiparasitic, antipsoriatic and antitumor properties. Piritrexim inhibits the enzyme dihydrofolate reductase enzyme, thereby disrupting folate metabolism and DNA synthesis and cell division." + }, + { + "input": "Concept: protein localization in septin ring (protein localization to cytoskeleton)", + "output": "protein localization to cell cortex described as a process in which a protein is transported to, or maintained in, a location within a septin ring." + }, + { + "input": "Concept: NCCN-FACT FOSI-18 Version 2 - Bothered by Treatment Side Effect (Intellectual Product)", + "output": "Intellectual Product described as national Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Ovarian Symptom Index-18 Version 2 - I am bothered by side effects of treatment." + }, + { + "input": "Concept: Diastasis, Symphysis Pubis (Osteoarthrosis and allied disorders)", + "output": "Arthropathy of pelvis described as separation of the PUBIC SYMPHYSIS. It is an uncommon complication of CHILDBIRTH causing postpartum PAIN, but it can also arise from other causes." + }, + { + "input": "Concept: CSS0309A (Intellectual Product)", + "output": "Intellectual Product described as columbia-Suicidality Severity Rating Scale Baseline/Screening Version Phase 1 Study 1/14/09 (C-SSRS Baseline/Screening Version Phase 1 Study 1/14/09) Could/can you stop thinking about killing yourself or wanting to die if you want to? (Lifetime)." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Infection, Parasite, Babesia Species, DNA (Medical Device)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Infection, Parasite, Babesia Species described as molecular assay reagents intended to identify species of Babesia, a genus of hematozoan protozoa, by detecting genetic information of the deoxyribonucleic acid (DNA) of the target parasite. Some species of these parasites may cause babesiosis (piroplasmosis), a disease characterized by malaria-like fever, chills, sweats, and myalgia. The parasite is typically transmitted to humans by rodent ticks." + }, + { + "input": "Concept: FLJ20073 (Gene or Genome)", + "output": "something described as human SAMD9 wild-type allele is located in the vicinity of 7q21.2 and is approximately 19 kb in length. This allele, which encodes sterile alpha motif domain-containing protein 9, may be involved in extra-osseous calcification, inflammatory responses and endosomal vesicle fusion. Mutation of the gene is associated with normophosphatemic familial tumoral calcinosis and MIRAGE syndrome." + }, + { + "input": "Concept: exerting (Function)", + "output": "Function described as physical or mental energy; hard work." + }, + { + "input": "Concept: Synovitis, NOS (Disorder of skeletal system)", + "output": "Arthritis described as inflammation of a synovial membrane." + }, + { + "input": "Concept: Biebrich scarlet (Indicator, Reagent, or Diagnostic Aid)", + "output": "something described as dye and chemical solution stains for medical purposes are mixtures of synthetic or natural dyes or nondye chemicals in solutions used in staining cells and tissues for diagnostic histopathology, cytopathology, or hematology." + }, + { + "input": "Concept: Gene Product Variant Of Gene Product (Conceptual Entity)", + "output": "Conceptual Entity described as a role used to indicate that a gene product sequence variation is related to a wild-type gene product. The domain and range for this role are 'Gene Product Sequence Variation' and 'Gene Product', respectively." + }, + { + "input": "Concept: morphogenesis of an epithelium (Organ or Tissue Function)", + "output": "tissue morphogenesis described as the process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." + }, + { + "input": "Concept: Grade 2 Agitation (Agitation, CTCAE 3.0)", + "output": "something described as moderate mood alteration" + }, + { + "input": "Concept: ADGRL3 gene (Gene or Genome)", + "output": "something described as this gene plays a role in cell-cell adhesion, G protein-coupled receptor signaling and neuronal migration." + }, + { + "input": "Concept: vertebral injury (Wounds and Injuries)", + "output": "Injury of trunk described as damage inflicted on the vertebral column as the direct or indirect result of an external force, with or without disruption of structural continuity." + }, + { + "input": "Concept: Fracture of Spine Related to Birth (Finding)", + "output": "Finding described as a broken vertebra sustained during the birthing process." + }, + { + "input": "Concept: Post-Radiotherapy Breast Angiosarcoma (Angiosarcoma of the breast)", + "output": "Angiosarcoma of the breast described as a malignant vascular neoplasm arising from the skin of the breast secondary to radiation treatment for breast cancer." + }, + { + "input": "Concept: Stage IVB Prostate Carcinoma AJCC v8 (Stage IV Prostate Cancer AJCC v8)", + "output": "Stage IV Prostate Cancer AJCC v8 described as stage IVB includes: Any T, N0, M1, PSA: Any, Grade Group: Any. N0: Prostate cancer with no positive regional nodes. M1: Prostate cancer with distant metastasis." + }, + { + "input": "Concept: CD16/IL15/CD33 trispecific killer cell engager (ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS)", + "output": "Pharmacologic Substance described as a trispecific killer engager (TriKE) molecule containing an anti-cluster of differentiation 16 (CD16; FcgammaRIII) single-chain variable fragment (scFv) to engage natural killer (NK) cells, an anti-CD33 scFv to engage myeloid cells and a human modified interleukin-15 (IL-15) linker, that links the two scFv, with potential immunomodulating and antineoplastic activities against CD33-expressing tumor cells. Upon administration of the CD16/IL15/CD33 TriKE, the simultaneous binding to CD16 on NK cells and CD33 on tumor cells will induce NK cell cytotoxicity specifically against CD33-expressing tumor cells. The cytokine IL-15 linker promotes NK cell proliferation, activity, survival and expansion. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and is overexpressed on myeloid leukemia cells." + }, + { + "input": "Concept: regulation of tRNA methylation (Genetic Function)", + "output": "something described as any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tRNA methylation." + }, + { + "input": "Concept: Global Alignment of Immunization safety Assessment in pregnancy Dysfunctional Labor Level of Diagnostic Certainty Terminology (Intellectual Product)", + "output": "GAIA Terminology described as a subset of terminology related to dysfunctional labor, developed by the Global Alignment of Immunization safety Assessment in pregnancy consortium to aid in monitoring and improving fetal and maternal outcomes." + }, + { + "input": "Concept: Role of Mitochondria in Apoptotic Signaling (Signal Transduction Pathways)", + "output": "Apoptosis Regulation Pathway described as mitochondria participate in apoptotic signaling pathways through the release of mitochondrial proteins into the cytoplasm. Cytochrome c, a key protein in electron transport, is released from mitochondria in response to apoptotic signals, and activates Apaf-1, a protease released from mitochondria. Activated Apaf-1 activates caspase-9 and the rest of the caspase pathway. Smac/DIABLO is released from mitochondria and inhibits IAP proteins that normally interact with caspase-9 to inhibit apoptosis. Apoptosis regulation by Bcl-2 family proteins occurs as family members form complexes that enter the mitochondrial membrane, regulating the release of cytochrome c and other proteins. TNF family receptors that cause apoptosis directly activate the caspase cascade, but can also activate Bid, a Bcl-2 family member, which activates mitochondria-mediated apoptosis. Bax, another Bcl-2 family member, is activated by this pathway to localize to the mitochondrial membrane and increase its permeability, releasing cytochrome c and other mitochondrial proteins. Bcl-2 and Bcl-xL prevent pore formation, blocking apoptosis. AIF (apoptosis inducing factor) is another mitochondrial factor that is released into the cytoplasm to induce apoptosis. AIF-induced apoptosis is important during development but is not caspase dependent." + }, + { + "input": "Concept: CLIP, REMOVABLE (Medical Device)", + "output": "Medical Device described as a removable skin clip is a clip-like device intended to connect skin tissues temporarily to aid healing. It is not absorbable." + }, + { + "input": "Concept: olfactory neuroblastoma of nasal cavity (Malignant neoplasm of nasal cavity)", + "output": "Olfactory Neuroblastoma described as an olfactory neuroblastoma arising in the nasal cavity." + }, + { + "input": "Concept: incomplete (Extensiveness)", + "output": "Extensiveness described as being or representing an incomplete extent of a single entity." + }, + { + "input": "Concept: POLYP ADENOMATOUS MULTIPLE (Benign Neoplasm)", + "output": "Benign adenomatous neoplasm - category described as a condition in which multiple adenomas develop in the gastrointestinal tract." + }, + { + "input": "Concept: atresia; urinary tract (Abnormality of the urinary system)", + "output": "something described as congenital absence of the normal opening of a structure of the urinary tract." + }, + { + "input": "Concept: ATP:protamine O-phosphotransferase (Amino Acid, Peptide, or Protein)", + "output": "Enzyme described as an aspect of protein kinase (EC 2.7.1.37) in which serine residues in protamines and histones are phosphorylated in the presence of ATP." + }, + { + "input": "Concept: Unexpected difficult airway (Anesthetic finding)", + "output": "something described as the clinical situation in which a conventionally trained anesthesiologist experiences difficulty with mask ventilation, difficulty with tracheal intubation or both." + }, + { + "input": "Concept: PARTNER-DDS - Not Working Well Together (PARTNER-DDS Questionnaire Question)", + "output": "something described as diabetes Distress Scale for Partners of Adults with Type 1 Diabetes - During the past month, I have been: Concerned that my partner and I are not working well together when it comes to diabetes." + }, + { + "input": "Concept: CDRS1-Hypoactivity (CDRS-R Clinical Classification Question)", + "output": "something described as children's Depression Rating Scale, Revised - Hypoactivity." + }, + { + "input": "Concept: V3 Loop of HIV-1 (Protein Structure)", + "output": "something described as third hypervariable region (V3) of the gp120 HIV envelope protein." + }, + { + "input": "Concept: Malignant tumors (Classification)", + "output": "Classification described as malignancies (SMQ) includes terms for: all types of malignant or unspecified tumors; malignancy related conditions; malignancy related therapeutic and diagnostic procedures; and tumour markers. [Note: Premalignant disorders are in a separate SMQ]. There are ten sub-SMQs which can be used separately or in combination. Malignancies (SMQ) is subdivided into four sub-SMQs: Malignant or unspecified tumours (SMQ); Malignancy related conditions (SMQ); Malignancy related therapeutic and diagnostic procedures (SMQ); and Tumour markers (SMQ). Malignant or unspecified tumours (SMQ) contains all MedDRA terms for malignant or unspecified tumors, which is further subdivided into two separate sub-SMQs: Malignant tumours (SMQ); and Tumours of unspecified malignancy (SMQ). Malignant tumours (SMQ) is subordinated by Haematological malignant tumours (SMQ); and Non-haematological malignant tumours (SMQ). Tumours of unspecified malignancy (SMQ) is subordinated by Haematological tumours of unspecified malignancy (SMQ); and Non-haematological tumours of unspecified malignancy (SMQ)." + }, + { + "input": "Concept: In the past 30 days, have you been trying to quit (or trying to stay off) smoking cigarettes (Clinical or Research Assessment Question)", + "output": "Clinical or Research Assessment Question described as a question about whether an individual has tried or has been trying to quit or stay off smoking cigarettes." + }, + { + "input": "Concept: modulation by symbiont of host cAMP-mediated signal transduction (Organism Function)", + "output": "Organism Function described as any process in which the symbiont modulates the frequency, rate or extent of cAMP-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." + }, + { + "input": "Concept: What was the severity of your acne or pimples on the face or chest at its worst (Clinical or Research Assessment Question)", + "output": "something described as a question about an individual's observation of the worst severity they have experienced related to acne or pimples on the face or chest over the past seven days." + }, + { + "input": "Concept: siRNA-expressing SV40 vector (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as a simian virus 40 (SV40)-based shuttle vector, encoding small interfering RNA (siRNA), with potential antineoplastic activity. The expression of siRNA in target tumor cells transfected with an siRNA-expressing SV40 vector may result in siRNA-mediated silencing of target oncogenes and, so, the inhibition of tumor cell growth and the induction of tumor cell death. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C62536\" active clinical trials using this agent." + }, + { + "input": "Concept: Biosynthesis of Glycine and Serine (Amino Acid Metabolism Pathway)", + "output": "Amino Acid Metabolism Pathway described as intermediates in energy production pathways such as glycolysis and the Kreb's cycle are commonly the starting point for the biosynthesis of amino acids. The glycolytic intermediate 3-phosphoglycerate is the starting point for the biosynthesis of serine and glycine. First, 3-phosphoglycerate is oxidized and then transaminated to produce 3-phosphoserine. Phosphoserine hydrolase hydrolyzes the phosphate in 3-phosphoserine to produce serine. The side chain carbon of serine is removed to create glycine, which has only hydrogen as its side chain. The removal of the serine side chain is accomplished by transferring the carbon to tetrahydrofolate, a carrier of one-carbon groups. Genetic deficiency of the first enzyme in the pathway, 3-phosphoglycerate dehydrogenase, leads to impaired myelination of neurons and impaired development of the central nervous system." + }, + { + "input": "Concept: maturation sexual (Organism Function)", + "output": "something described as achievement of full sexual capacity in animals and in humans." + }, + { + "input": "Concept: activation of KMN complex assembly involved in chromosome segregation (regulation of NMS complex assembly)", + "output": "something described as any process that activates or increases the frequency, rate or extent of NMS complex assembly. The NMS complex is involved in chromosome segregation." + }, + { + "input": "Concept: Fatty Acid 22:1 n-9 (Erucic Acids)", + "output": "Erucic Acids described as a monounsaturated very long-chain fatty acid with a 22-carbon backbone and a single double bond originating from the 9th position from the methyl end." + }, + { + "input": "Concept: iodine I 131 MOAB 3F8 (Pharmacologic Substance)", + "output": "Immunologic Factor described as a radioimmunoconjugate consisting of 3F8, a murine anti-GD2 ganglioside monoclonal antibody labeled with iodine 131 (I-131), with radioimaging and radioimmunotherapeutic properties. Using monoclonal antibody 3F8 as a carrier for I-131 results in the targeted imaging and/or destruction of cells expressing GD2. GD2 is a ganglioside which is overexpressed in malignant melanoma, neuroblastoma, and small cell carcinoma of the lung. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2431\" active clinical trials using this agent." + }, + { + "input": "Concept: efferent cochlear group (Body Part, Organ, or Organ Component)", + "output": "something described as a group of cells defined on the basis of function as belonging to the somatic motoneuron pools of the subcortical motor system of the cerebrospinal trunk ( Swanson-2004 )." + }, + { + "input": "Concept: CTCAE Grade 1 Myositis (Myositis, CTCAE 5.0)", + "output": "something described as mild pain" + }, + { + "input": "Concept: papillomata (Papillary Epithelial Neoplasm)", + "output": "Neonatal and infancy disorder described as a benign epithelial neoplasm that projects above the surrounding epithelial surface and consists of villous or arborescent outgrowths of fibrovascular stroma." + }, + { + "input": "Concept: Ferredoxin-Nitrite Reductase (Oxidoreductase)", + "output": "Amino Acid, Peptide, or Protein described as an IRON-containing protein that uses siroheme and 4Fe-4S iron-sulfur centers as prosthetic groups. It catalyzes the six-electron oxidation of AMMONIA to nitrite." + }, + { + "input": "Concept: Z (Spatial Concept)", + "output": "Dimensions described as the magnitude of something in a third direction, generally representing depth." + }, + { + "input": "Concept: cyclic-GMP-AMP synthase activity (nucleotidyltransferase activity)", + "output": "something described as catalysis of the reaction: ATP + GTP = 2 diphosphate + cyclic GMP-AMP." + }, + { + "input": "Concept: cerebral; cysticercosis (Cysticercosis)", + "output": "Infectious disease of brain described as infection of the brain, spinal cord, or perimeningeal structures with the larval forms of the genus TAENIA (primarily T. solium in humans). Lesions formed by the organism are referred to as cysticerci. The infection may be subacute or chronic, and the severity of symptoms depends on the severity of the host immune response and the location and number of lesions. SEIZURES represent the most common clinical manifestation although focal neurologic deficits may occur." + }, + { + "input": "Concept: How Difficult to Lift Items over 10 Pounds with Affected Arm (Clinical or Research Assessment Question)", + "output": "Clinical or Research Assessment Question described as a question about how difficult it is for an individual to lift items over 10 pounds with their affected arm." + }, + { + "input": "Concept: allogeneic adult mesenchymal stem cells (Non-Tumor Cell Derivative Vaccine)", + "output": "Cell described as human mesenchymal stem cells (MSCs) harvested from bone marrow of healthy adult donors and expanded ex vivo, with potential immunosuppressive activity. Remestemcel-L cells are hypo-immunogenic due to lack of major histocompatibility II (MHC II) molecule expression, eliciting little, if any, host immune response upon intravenous infusion. Infusion of allogeneic MSCs may result in: a) increased production of anti-inflammatory cytokines, such as interleukin-10, prostaglandin E, and hepatocyte growth factor; b) decreased mononuclear phagocyte expression of indoleamine 2,3,-dioxygenase, which catabolizes L-tryptophan into its pro-inflammatory metabolites; and c) modulated dendritic cell (DC)maturation and disrupted activities of natural killer (NK) cells and CD8+ and CD4+ T cells. In addition, pluripotent MSCs, upon administration, may be recruited to damaged tissue sites, differentiating along specific lineages when stimulated. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C67082\" active clinical trials using this agent." + }, + { + "input": "Concept: reovirus (Virus)", + "output": "Spinareovirinae described as genus of the family reoviridae infecting vertebrates only; transmission is horizontal and infected species include humans, birds, cattle, monkeys, sheep, swine, baboons, and bats." + }, + { + "input": "Concept: Assay of serum albumin (Measurement of level of substance in blood)", + "output": "Serum Chemistry Measurement described as a quantitative measurement of the amount of albumin present in a sample of serum." + }, + { + "input": "Concept: Pharmacy Distribution Center (Manufactured Object)", + "output": "something described as a place where drugs are received from manufacturer and stored for future shipment to other sites." + }, + { + "input": "Concept: Protein Lin-28 Homolog B (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as protein lin-28 homolog B (250 aa, ~27 kDa) is encoded by the human LIN28B gene. This protein plays a role in the degradation of pre-miRNA." + }, + { + "input": "Concept: National Cancer Advisory Board (Health Care Related Organization)", + "output": "NCI Advisory Board or Group described as advise the Secretary, Department of Health and Human Services and the Director, NCI, with respect to the activities of the Institute including reviewing and recommending for support grants and cooperative agreements, following technical and scientific peer review." + }, + { + "input": "Concept: Main portal venous trunk (Portal vein structure)", + "output": "something described as trunk of portal vein that connects the portal vein proper to the hepatic portal vein. Examples: There is only one main portal venous trunk." + }, + { + "input": "Concept: Syndecan Binding Proteins (Adaptor Proteins, Signal Transducing)", + "output": "Biologically Active Substance described as intracellular signaling adaptor proteins that play a role in the coupling of SYNDECANS to CYTOSKELETAL PROTEINS." + }, + { + "input": "Concept: StudyReference.publicationIdentifier (Publication Identifier)", + "output": "Publication Identifier described as a unique symbol that establishes identity of a publication related to the study protocol background. EXAMPLE(S): 10987815 is the unique PubMed Identifier (PMID) for the citation in MEDLINE." + }, + { + "input": "Concept: CD14 gene (Gene or Genome)", + "output": "Cell Adhesion Molecule Gene described as this gene plays a role in apoptosis and in ligand-binding interactions." + }, + { + "input": "Concept: ADITOPRIM (Dihydrofolate Reductase Inhibitors)", + "output": "Dihydrofolate Reductase Inhibitors described as a long-acting, selective, reversible inhibitor of dihydrofolate reductase with application as a broad-spectrum antibacterial agent in animals." + }, + { + "input": "Concept: HDL clearance (Cell Function)", + "output": "Cell Function described as the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." + }, + { + "input": "Concept: Theileria parva (Theiler, 1904) Bettencourt, Franca & Borges, 1907 (Eukaryote)", + "output": "Theileria sp. described as a protozoan parasite that is the etiologic agent of East Coast fever (THEILERIASIS). Transmission is by ticks of the Physicephalus and Hyalomma genera." + }, + { + "input": "Concept: Indigenous medicine (Anthropological Culture)", + "output": "Therapeutic procedure described as traditional medicine is the sum total of the knowledge, skill, and practices based on the theories, beliefs, and experiences indigenous to different cultures, whether explicable or not, used in the maintenance of health as well as in the prevention, diagnosis, improvement or treatment of physical and mental illness." + }, + { + "input": "Concept: Acquiring single words or meaningful symbols (Acquiring language)", + "output": "something described as learning words or meaningful symbols, such as graphic or manual signs or symbols." + }, + { + "input": "Concept: negative regulation of mesenchymal cell proliferation involved in ureter development (negative regulation of multicellular organismal process)", + "output": "regulation of mesenchymal cell proliferation involved in ureter development described as any process that decreases the frequency, rate or extent of mesenchymal cell proliferation that contributes to the progression of the ureter gland over time. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." + }, + { + "input": "Concept: CEA peptide-1 (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as a nine amino acid peptide fragment of carcinoembryonic antigen (CEA), a protein that is overexpressed in several cancer cell types, including gastrointestinal, breast, and non-small cell lung. Autologous vaccination with activated autologous dendritic cells (DC) or peripheral blood mononuclear cells (PBMC) which have been exposed to CEA peptide 1 in vitro may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells expressing CEA, thereby inhibiting tumor growth." + }, + { + "input": "Concept: Type II Secretion System (Transport Pathway)", + "output": "Transport Pathway described as gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway." + }, + { + "input": "Concept: Popliteal Angle Measurement (Research or Clinical Assessment Tool)", + "output": "Diagnostic Procedure described as a test of neuromuscular maturity, which measures leg extensibility and resistance to extensor stretching, used during the clinical assessment of gestational age and muscle tone during the first five days of life." + }, + { + "input": "Concept: ISSPID (Sponsor ID)", + "output": "something described as one or more sponsor defined characters used to identify, name, or characterize the immunogenicity specimen assessment." + }, + { + "input": "Concept: hydroxyindoleacetate (indoleacetate)", + "output": "Biologically Active Substance described as hydroxy substituted acetic acid derivatives of the heterocyclic compound indole; 5-hydroxyindoleacetic acid is a metabolite of the neurotransmitter serotonin, and secreted in large amounts by patients with carcinoid tumors." + }, + { + "input": "Concept: zymogen binding (enzyme binding)", + "output": "enzyme binding described as interacting selectively and non-covalently with a zymogen, an enzymatically inactive precursor of an enzyme that is often convertible to an active enzyme by proteolysis." + }, + { + "input": "Concept: EEG frontal sharp waves (EEG with focal sharp waves)", + "output": "something described as EEG with sharp waves in the frontal region, i.e., sharp transient waves of a duration between 80 and 200 msec." + }, + { + "input": "Concept: Poly ADP Ribose (Polyribonucleotides)", + "output": "Nucleic Acid, Nucleoside, or Nucleotide described as a polynucleotide formed from the ADP-RIBOSE moiety of nicotinamide-adenine dinucleotide (NAD) by POLY(ADP-RIBOSE) POLYMERASES." + }, + { + "input": "Concept: C-SSRS Children's Baseline - Description of Actual Suicide Attempt (Intellectual Product)", + "output": "C-SSRS Children's Baseline Questionnaire Question described as columbia-Suicidality Severity Rating Scale Children's Baseline (C-SSRS Children's Baseline) Description of actual attempt." + }, + { + "input": "Concept: Active chronic hepatitis (Liver damage)", + "output": "Hepatitis, Chronic described as an aggressive form of chronic hepatitis involving extensive liver damage and cell injury beyond the portal tract." + }, + { + "input": "Concept: ranking (Unapproved attribute)", + "output": "hierarchical relationship and related descriptors described as a relative status as compared to others within a group." + }, + { + "input": "Concept: PMX2B Gene Mutation (Cell or Molecular Dysfunction)", + "output": "Gene Mutant described as a change in the nucleotide sequence of the PHOX2B gene." + }, + { + "input": "Concept: HSP90 antagonist CNF2024 (HSP90 Inhibitor)", + "output": "HSP90 Inhibitor described as an orally active, purine-scaffold, small-molecule inhibitor of heat shock protein 90 (HSP90) with potential antineoplastic activity. HSP90 inhibitor CNF2024 specifically blocks active HSP90, inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival; this may result in the inhibition of cellular proliferation in susceptible tumor cell populations. HSP90, a chaperone protein upregulated in a variety of tumor cell types, regulates the folding and degradation of many oncogenic signaling proteins. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C62517\" active clinical trials using this agent." + }, + { + "input": "Concept: hypersensitivity reactions (Allergic Reaction)", + "output": "something described as known to have allergic reactions to particular substance" + }, + { + "input": "Concept: Anti-LAMP1 ADC SAR428926 (Monoclonal Antibodies)", + "output": "Antineoplastic Antibody-Drug Conjugate described as an antibody-drug conjugate (ADC) consisting of a monoclonal antibody against lysosome-associated membrane protein 1 (LAMP1) conjugated, via the disulfide-containing cleavable linker N-succinimidyl-4-(2-pyridyldithio)butyrate (SPDB), to the cytotoxic maytansinoid DM4, with potential antineoplastic activity. Upon administration of anti-LAMP1 ADC SAR428926, the anti-LAMP1 monoclonal antibody moiety targets and binds to the cell surface antigen LAMP1. After antibody-antigen interaction and internalization, the SPDB linker is selectively cleaved by proteases in the cytosol and the DM4 moiety is released. DM4 binds to tubulin and disrupts microtubule assembly/disassembly dynamics, thereby inhibiting both cell division and cell growth of LAMP1-expressing tumor cells. LAMP1, overexpressed on a variety of cancer cells, plays a key role in cell-cell adhesion and migration. The SPDB linker is resistant to cleavage in the bloodstream, which may increase stability and reduce toxicity." + }, + { + "input": "Concept: sociologist (Social scientist)", + "output": "Professional or Occupational Group described as individual trained in the science dealing with social relations and phenomena." + }, + { + "input": "Concept: Kali muriaticum / potasssium chloride (Homeopathic remedies letter K)", + "output": "Homeopathic remedies letter K described as chloride of potassium." + }, + { + "input": "Concept: S. pneumonia Sero 33F IgG AB (Streptococcus pneumoniae IgG Antibody Measurement)", + "output": "Laboratory Procedure described as the determination of the amount of Streptococcus pneumoniae serotype 33F IgG antibody present in a sample." + }, + { + "input": "Concept: CYHGBC (Laboratory Procedure)", + "output": "Hematologic Tests described as a measurement of hemoglobin C crystals in a biological specimen." + }, + { + "input": "Concept: Frequency (All)", + "output": "something described as class to represent frequency of phenotypic abnormalities within a patient cohort. []" + }, + { + "input": "Concept: Cardiac Output Units, Direct Fick (Cardiac output unit)", + "output": "something described as cardiac output units that measure blood volume and flow rate from the heart based on the Fick's law of diffusion. The direct Fick method is based on an assumed value of body oxygen consumption rather than a real measurement of its value. Fick measurement of cardiac output processes the measurements of oxygen consumption, venous blood oxygen, and arterial blood oxygen; a computer unit (or a standard computer) using an algorithm calculates the approximate value of cardiac output as the quotient of total body oxygen consumption divided by the difference in oxygen content of arterial blood and mixed venous blood. This technique is currently used infrequently to measure cardiac output." + }, + { + "input": "Concept: positive regulation of vascular wound healing (Organism Function)", + "output": "Positive Regulation of Angiogenesis described as any process that increases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature." + }, + { + "input": "Concept: PAR 01 RECEPTOR (Thrombin Receptor)", + "output": "Thrombin Receptor described as a thrombin receptor subtype that couples to HETEROTRIMERIC GTP-BINDING PROTEINS resulting in the activation of a variety of signaling mechanisms including decreased intracellular CYCLIC AMP, increased TYPE C PHOSPHOLIPASES and increased PHOSPHOLIPASE A2." + }, + { + "input": "Concept: CEFETAMET PIVOXIL HYDROCHLORIDE (Antibiotic)", + "output": "something described as the hydrochloride salt form of cefetamet pivoxil, a pivalate ester prodrug form of a cefetamet. After oral administration of cefetamet pivoxil hydrochloride, the ester bond is cleaved, releasing active cefetamet." + }, + { + "input": "Concept: preclinical study (Research Activity)", + "output": "Research Activity described as research using animals to find out if a drug, procedure, or treatment is likely to be useful. Preclinical studies take place before any testing in humans is done." + }, + { + "input": "Concept: SOLUTE CARRIER FAMILY 5 (IODIDE TRANSPORTER), MEMBER 8 (Gene or Genome)", + "output": "Transport Protein Gene described as this gene is involved in the transport of sodium cations, chloride anions, iodide and monocarboxylates." + }, + { + "input": "Concept: rndx rape trauma syndrome (Nursing Assessment Entity)", + "output": "Post-trauma response described as sustained maladaptive response to a forced, violent, sexual penetration against the victim's will and consent." + }, + { + "input": "Concept: 11q12 (Chromosome band)", + "output": "something described as a chromosome band present on 11q" + }, + { + "input": "Concept: DAT (Date in time)", + "output": "Temporal Concept described as the date that the test was performed." + }, + { + "input": "Concept: RADIOIMMUNOASSAY, TRICYCLIC ANTIDEPRESSANT DRUGS (Medical Device)", + "output": "Medical Device described as a tricyclic antidepressant drugs test system is a device intended to measure any of the tricyclic antidepressant drugs in serum. The tricyclic antidepressant drugs include imipramine, desipramine, amitriptyline, nortriptyline, protriptyline, and doxepin. Measurements obtained by this device are used in the diagnosis and treatment of chronic depression to ensure appropriate therapy." + }, + { + "input": "Concept: Acanthameba palestinensis (Acanthamoeba)", + "output": "something described as any amoebic organism that can be assigned to the species Acanthamoeba palestinensis." + }, + { + "input": "Concept: Grade 2 Infections and Infestations - Other, Specify, CTCAE (Infections and Infestations - Other, Specify, CTCAE)", + "output": "Finding described as moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL" + }, + { + "input": "Concept: Learning Environment (Academic Learning & Achievement)", + "output": "Academic Learning & Achievement described as used for any environment where learning can occur. Not limited to educational settings." + }, + { + "input": "Concept: Dermcidins (Antibiotic)", + "output": "something described as 47-amino acid peptides secreted by ECCRINE GLANDS and having a role in innate cutaneous defense, being antimicrobial to some pathogenic BACTERIA. They are overexpressed by some primary BREAST CANCER cells. They are derived from 110 residue PROTEIN PRECURSORS." + }, + { + "input": "Concept: oligodendrocyte cell development (Cell Function)", + "output": "something described as the process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system." + }, + { + "input": "Concept: Time to Platelet Recovery (Temporal Concept)", + "output": "Temporal Concept described as the duration of time it takes for an individual who has had chemotherapy-induced low platelets to achieve an acceptable number of platelets in the blood." + }, + { + "input": "Concept: 2',3'-dideoxycytidine (Pharmacologic Substance)", + "output": "Immunomodulators described as a synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zalcitabine preferentially inhibits the gamma form of DNA polymerase present in tumor cell mitochondria, resulting in the inhibition of tumor cell mitochondrial DNA replication and tumor cell death. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C430\" active clinical trials using this agent." + }, + { + "input": "Concept: {Ejaculate U} (Miscellaneous Unit)", + "output": "Quantitative Concept described as a unit of volume equal to the amount of seminal fluid produced by a single ejaculation event." + }, + { + "input": "Concept: Ganitumab (Immunologic Factor)", + "output": "Immunologic Factor described as a recombinant, fully human monoclonal antibody directed against the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Ganitumab binds to membrane-bound IGF-1R, preventing binding of the ligand IGF-1 and the subsequent triggering of the PI3K/Akt signaling pathway; inhibition of this survival signaling pathway may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-1R is a tyrosine kinase and a member of the insulin receptor family. IGF-1R activation stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis; IGF-1R signaling has been highly implicated in tumorigenesis and metastasis." + }, + { + "input": "Concept: Electrospray Ionization (Research Techniques)", + "output": "Laboratory Procedure described as a procedure used in mass spectrometry analysis. Means of delivering nonvolatile analytes into the gas phase for mass analysis. Best used on molecules which are charged in solution or readily accept a charge. Particularly well suited to the analysis of biomolecules. Can be used to probe tertiary structure and non-covalent interactions" + }, + { + "input": "Concept: Brooke Modified Medical Research Council Manual Muscle Test Score, Flexion (Finding)", + "output": "Score described as the numerical value that represents the result of a clinical assessment of muscle strength and function during flexion that is based on the Brooke Modified Medical Research Council Manual Muscle Test. (Brooke MH, Griggs RC, Mendell JR, Fenichel GM, et al. Clinical trial in Duchenne dystrophy. I. The design of the protocol. Muscle Nerve. 1981 May-Jun;4(3):186-97. doi:10.1002/mus.880040304)." + }, + { + "input": "Concept: DASATINIB (Enzyme Inhibitors)", + "output": "growth-signaling inhibitors described as an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C38713\" active clinical trials using this agent." + }, + { + "input": "Concept: Clathrin Heavy Chain 1/ALK Tyrosine Kinase Receptor Fusion Protein (Fusion protein)", + "output": "something described as a fusion protein that is encoded by the CLTC/ALK fusion gene. This protein contains most of the clathrin heavy chain 1 protein including the trimerization domain and the cytoplasmic domain of the ALK tyrosine kinase receptor protein." + }, + { + "input": "Concept: Right lung field/right chest (Finding)", + "output": "something described as heart sounds are auscultated on the precordial location corresponding the pleural apices, middle and lower or base, posteriorly, laterally and anteriorly of the right lung." + }, + { + "input": "Concept: Congenital pseudoarthrosis of limb (Limb Deformities, Congenital)", + "output": "Limb Deformities, Congenital described as a rare genetic non-syndromic limb malformation with characteristics of delayed union or non-union of a long bone, resulting in formation of a false joint, with abnormal mobility and angulation at the pseudoarthrosis site, which manifests with progressive anterolateral forearm or leg bowing, limb shortening, and non-healing fractures. Typical histopathological findings include fibromatosis-like proliferation in the soft tissues with cystic or dysplastic lesions. Neurofibromatosis and osteofibrous dysplasia are frequently associated." + }, + { + "input": "Concept: IPAQ Long Last 7 Days Self-Administered Format Version - Days Walk Place to Place (IPAQ Long Last 7 Days Self-Administered Format Version Questionnaire Question)", + "output": "IPAQ Long Last 7 Days Self-Administered Format Version Questionnaire Question described as international Physical Activity Questionnaire (October 2002) - Long Last 7 Days Self-Administered Format - During the last 7 days, on how many days did you walk for at least 10 minutes at a time to go from place to place?: days per week." + }, + { + "input": "Concept: When I do have pain, it is mildly distressing (Intellectual Product)", + "output": "something described as a response indicating that when an individual has or had pain, was mildly distressing." + }, + { + "input": "Concept: Testing (Evaluation procedure)", + "output": "Measurement described as a procedure for critical evaluation." + }, + { + "input": "Concept: keratin 10, human (Amino Acid, Peptide, or Protein)", + "output": "something described as keratin, type I cytoskeletal 10 (584 aa, ~59 kDa) is encoded by the human KRT10 gene. This protein plays a role in the structure of intermediate filaments." + }, + { + "input": "Concept: Heart Bypasses, Left (Extracorporeal Circulation)", + "output": "Therapeutic or Preventive Procedure described as diversion of the flow of blood from the pulmonary veins directly to the aorta, avoiding the left atrium and the left ventricle (Dorland, 27th ed). This is a temporary procedure usually performed to assist other surgical procedures." + }, + { + "input": "Concept: Hydrogen Carbonates (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as inorganic salts that contain the -HCO3 radical. They are an important factor in determining the pH of the blood and the concentration of bicarbonate ions is regulated by the kidney. Levels in the blood are an index of the alkali reserve or buffering capacity." + }, + { + "input": "Concept: Nutrition, Food Additives (Nutrition, Dietary Components)", + "output": "Nutrition, Dietary Components described as role of food additives in cancer causation or prevention and in general health." + }, + { + "input": "Concept: Was Another CD Antigen Tested (Intellectual Product)", + "output": "Was Additional Testing Performed described as a question asking if testing for a CD antigen that is no present on the form was performed during the study." + }, + { + "input": "Concept: interleukin-35 secretion (Cell Function)", + "output": "cytokine secretion described as the regulated release of interleukin-35 from a cell." + }, + { + "input": "Concept: Dioxygenases (Oxidoreductase)", + "output": "Oxygenases described as non-heme iron-containing enzymes that incorporate two atoms of OXYGEN into the substrate. They are important in biosynthesis of FLAVONOIDS; GIBBERELLINS; and HYOSCYAMINE; and for degradation of AROMATIC HYDROCARBONS." + }, + { + "input": "Concept: Prx activity (antioxidant activity)", + "output": "something described as catalysis of the reaction: 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH." + }, + { + "input": "Concept: LUNG BLEBS (Lung)", + "output": "Disease or Syndrome described as pulmonary bullae are rounded focal regions of emphysema with a thin wall which measure more than 1 cm in diameter. They are often subpleural in location and are typically larger in the apices. In some cases, bullae can be very large and result in compression of adjacent lung tissue. A giant bulla is arbitrarily defined as one that occupies at least one third of the volume of a hemithorax. When large, bullae can simulate pneumothorax. The most common cause is paraseptal emphysema but bullae may also be seen in association with centrilobular emphysema." + }, + { + "input": "Concept: Tropisetron product (Azoles)", + "output": "T [Preparations] described as an indole derivative and 5-HT3 RECEPTOR antagonist that is used for the prevention of nausea and vomiting." + }, + { + "input": "Concept: Clock Homolog (histone acetyltransferase)", + "output": "histone acetyltransferase described as circadian locomoter output cycles protein kaput (846 aa, ~95 kDa) is encoded by the human CLOCK gene. This protein plays a role in the modulation of histone acetylation that regulates both gene expression and circadian rhythms." + }, + { + "input": "Concept: Sexually Transmitted Chlamydial Disease (Disease or Syndrome)", + "output": "Chlamydia Infections described as a chlamydial infection that was sexually transmitted." + }, + { + "input": "Concept: Homoharringtonine (Differentiation Inducer)", + "output": "Pharmacologic Substance described as semisynthetic derivative of harringtonine that acts as a protein synthesis inhibitor and induces APOPTOSIS in tumor cells. It is used in the treatment of MYELOID LEUKEMIA, CHRONIC." + }, + { + "input": "Concept: hydrocarbon (Organic Chemical)", + "output": "Hydrocarbons described as a substance made of only hydrogen and carbon. Examples of hydrocarbons are coal, petroleum, natural gas and tar. They are used as energy sources. Being exposed to hydrocarbons may increase the risk of certain types of cancer." + }, + { + "input": "Concept: INTRACRANIAL NEOPLASM, MEDULLOBLASTOMA (Neuroendocrine Tumors)", + "output": "Neuroectodermal Tumor, Primitive described as a rapidly progressive cancer of the brain that originates in the cerebellum." + }, + { + "input": "Concept: alkane catabolic process (Cell Function)", + "output": "cellular alkane metabolic process described as the chemical reactions and pathways resulting in the breakdown of an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2." + }, + { + "input": "Concept: UVA - Ultraviolet A radiation (Natural Phenomenon or Process)", + "output": "something described as invisible rays that are part of the energy that comes from the sun. Ultraviolet A radiation also comes from sun lamps and tanning beds. Ultraviolet A radiation may cause premature aging of the skin and skin cancer. It may also cause problems with the eyes and the immune system. Skin specialists recommend that people use sunscreens that protect the skin from ultraviolet radiation. In medicine, ultraviolet A radiation also comes from special lamps or a laser and is used to treat certain skin conditions such as psoriasis, vitiligo, and skin tumors of cutaneous T-cell lymphoma." + }, + { + "input": "Concept: ALCOHOL EFFECT (Clinical Trial Type)", + "output": "Clinical Trial Type described as a type of study designed to evaluate the effects of alcohol on drug safety and efficacy." + }, + { + "input": "Concept: GPI-anchor transamidase complex (catalytic complex location)", + "output": "Cell Component described as an enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxy-terminus of a precursor protein to a GPI-anchor." + }, + { + "input": "Concept: hsa-mir-520c (MicroRNA Gene)", + "output": "something described as this gene is involved in the regulation of gene expression and plays a role in the development of carcinoma of the breast." + }, + { + "input": "Concept: PODCI2-His/Her Body (Intellectual Product)", + "output": "something described as pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported - During the last week, how happy has your child been with: His/her body?" + }, + { + "input": "Concept: Congenital iodine deficiency hypothyroidism (Multiple malformation syndrome due to non-infectious environmental agents)", + "output": "Congenital anomaly of the thyroid gland described as thyroid hormone deficiency present at birth and caused by iodine deficiency." + }, + { + "input": "Concept: Generalized arteriosclerosis (Arteriosclerosis)", + "output": "Arteriosclerosis described as arteriosclerosis that is not localized." + }, + { + "input": "Concept: Software.licenseEffectiveDateRange (License Effective Date Range)", + "output": "License Effective Date Range described as the date and time span for when the license for this software is active. EXAMPLE(S): OTHER NAME(S): NOTE(S):" + }, + { + "input": "Concept: IVD Test Reagent/Kits, Immunoassay, Therapeutic Drug, Anticonvulsant, Phenytoin, Free (IVD Test Reagent/Kits, Immunoassay, Therapeutic Drug, Anticonvulsant, Phenytoin)", + "output": "IVD Test Reagent/Kits, Immunoassay, Therapeutic Drug, Anticonvulsant, Phenytoin described as immunoassay reagents intended to perform quantitative analyses of a sample of human serum or plasma to measure levels of free phenytoin (the bioactive component of phenytoin in blood) present in the sample. Reagents for measuring levels of free phenytoin are used to monitor the drug levels in patients undergoing treatment, either to determine the adequacy of drug treatment or to diagnose a drug overdose or drug-related toxicity." + }, + { + "input": "Concept: Shedding, Bacterial (Physiological Processes)", + "output": "Physiological Phenomena described as the expelling of bacteria from the body. Important routes include the respiratory tract, genital tract, and intestinal tract." + }, + { + "input": "Concept: Laser Device (Device Component or Accessory)", + "output": "Medical Device described as a device designed to emit a monochromatic beam of coherent light." + }, + { + "input": "Concept: AQ20 - Chest Trouble Make You Go Home Sooner Than Others (AQ20 Questionnaire Question)", + "output": "something described as airway Questionnaire 20 - Does your chest trouble make you go home sooner than others after a night out?" + }, + { + "input": "Concept: modulation by symbiont of host NF-kappaB-mediated signal transduction pathway (Molecular Function)", + "output": "Molecular Function described as any process in which an organism modulates the frequency, rate or extent of host NF-kappaB-mediated signal transduction pathways during the host defense response. The host is defined as the larger of the organisms involved in a symbiotic interaction." + }, + { + "input": "Concept: painful; menstruation (Disease or Syndrome)", + "output": "Finding of menstrual bleeding described as painful menstruation." + }, + { + "input": "Concept: Glycine N-Methyltransferase Deficiency (Hypermethioninemia)", + "output": "Congenital Disorders described as a rare genetic inborn error of metabolism characterised by a relatively benign clinical phenotype, with only mild to moderate hepatomegaly reported, in addition to laboratory studies revealing permanent, greatly increased hypermethioninaemia, mild to moderate elevation of aminotransferases and highly elevated plasma S-adenosyl-methionine with normal S-adenosylhomocysteine and total homocysteine. The disease is caused by homozygous or compound heterozygous mutation in the GNMT gene on chromosome 6p21." + }, + { + "input": "Concept: Proto-Oncogene c-Maf (Basic-Leucine Zipper Transcription Factors)", + "output": "Basic-Leucine Zipper Transcription Factors described as maf transcription factors are a family of basic-leucine zipper transcription factors that are closely related to V-MAF ONCOGENE PROTEIN. The C-MAF PROTO-ONCOGENE PROTEIN was the first mammalian Maf transcription factor identified, and now the family is known to include a variety of other Maf proteins such as MAFB TRANSCRIPTION FACTOR; MAFF TRANSCRIPTION FACTOR; MAFG TRANSCRIPTION FACTOR; and MAFK TRANSCRIPTION FACTOR." + }, + { + "input": "Concept: Strophanthins (Cardiac Glycosides)", + "output": "Organic Chemical described as a number of different cardioactive glycosides obtained from Strophanthus species. OUABAIN is from S. gratus and CYMARINE from S. kombe. They are used like the digitalis glycosides." + }, + { + "input": "Concept: MNSI119 (MNSI Questionnaire Question)", + "output": "Intellectual Product described as michigan Neuropathy Screening Instrument (MNSI) Physical assessment; appearance of right foot - dry skin, callus." + }, + { + "input": "Concept: Vaginas (Female internal genitalia structure)", + "output": "Female Reproductive System described as the female genital canal, extending from the uterus to the vulva." + }, + { + "input": "Concept: marfanoid habitus-mental retardation syndrome (Disease or Syndrome)", + "output": "Disease or Syndrome described as a syndrome marked by marfanoid habitus (tall stature with long and slim limbs, little subcutaneous fat, arachnodactyly, joint hyperextensibility, narrow face, small chin, large testes, and hypotonia) associated with psychomotor retardation." + }, + { + "input": "Concept: Ensituximab (Amino Acid, Peptide, or Protein)", + "output": "Monoclonal Antibodies described as a chimeric monoclonal antibody against human colorectal and pancreatic carcinoma-associated antigens (CPAAs) with potential immunomodulating and anti-tumor activities. Ensituximab binds to CPAAs, which may activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response and an antibody-dependent cellular cytotoxicity (ADCC) response against CPAA-expressing tumor cells. CPAAs, cell surface proteins, are upregulated on colon and pancreatic tumor cells. Ensituximab contains the variable region of the heavy and light chain of murine NPC-1 and linked in-frame to constant regions of a human IgG1 isotype. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C90532\" active clinical trials using this agent." + }, + { + "input": "Concept: disease (or disorder); respiratory tract, due to cotton dust (Endotoxicosis)", + "output": "Pneumoconiosis described as a condition of BRONCHOCONSTRICTION resulting from hypersensitive reaction to inhaled dust during the initial processing of cotton, flax, or hemp in the textile industry. Symptoms include wheezing and tightness in the chest." + }, + { + "input": "Concept: (R)-2-hydroxyglutarate dehydrogenase activity (oxidoreductase activity, acting on CH-OH group of donors)", + "output": "Molecular Function described as catalysis of the reaction: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor." + }, + { + "input": "Concept: Mouse Colon Adenocarcinoma (Adenocarcinoma of the Mouse Intestinal Tract)", + "output": "Neoplastic Process described as an adenocarcinoma arising from the colon of a mouse. It can be used as a mouse model of the human disease." + }, + { + "input": "Concept: Initial Teaching Alphabet (Teaching & Teaching Methods)", + "output": "Teaching & Teaching Methods described as a system developed in England in 1959 that uses a phoneme-grapheme correspondence to stress consistency between symbol and sound for beginning reading instruction." + }, + { + "input": "Concept: Mefanamic acid (Organic Chemical)", + "output": "something described as a non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase." + }, + { + "input": "Concept: STAT6B (STAT6 gene)", + "output": "STAT6 gene described as human STAT6 wild-type allele is located in the vicinity of 12q13 and is approximately 16 kb in length. This allele, which encodes signal transducer and activator of transcription 6 protein, plays a role in apoptosis regulation, T helper cell differentiation, immunoglobulin class determination and the cellular response to interleukin-4." + }, + { + "input": "Concept: surgically induced abortion therapeutic (Elective abortion)", + "output": "Obstetrics excision described as delivery by means of therapeutic termination of pregnancy. Therapeutic abortion may be done to end a pregnancy if the mother's life is in danger or if the baby has abnormalities involving the major organ systems and is not expected to survive after birth or by choice." + }, + { + "input": "Concept: Malagasy (Asians)", + "output": "Asians described as a person having origins in any of the original peoples of Madagascar." + }, + { + "input": "Concept: Cortisol, Free Excretion Rate (Laboratory Procedure)", + "output": "something described as the determination of the amount of free cortisol being excreted in a biological specimen over a defined period of time." + }, + { + "input": "Concept: hysterosalpingograms (Diagnostic Procedure)", + "output": "hysterosalpingogram described as radiography of the uterus and fallopian tubes after the injection of a contrast medium." + }, + { + "input": "Concept: BHR-200 (Therapeutic Estradiol)", + "output": "Therapeutic Estradiol described as a proprietary, transdermal, hydroalcoholic gel formulation containing 17beta-estradiol, with potential antineoplastic activity. Upon topical administration, 17beta-estradiol exerts its antineoplastic effect(s) through as of yet not fully elucidated mechanism(s) of action(s). This formulation may induce feedback inhibition via the hypothalamic-pituitary-gonadal axis feedback loop, block the secretion of luteinizing hormone (LH) and prevent the release of testosterone from Leydig cells in the testes, thus suppressing testosterone secretion. In addition, 17beta-estradiol inhibits enzymes involved in steroidogenesis, thereby further inhibiting androgen production. Since testosterone is required to sustain prostate growth, reducing testosterone levels may inhibit hormone-dependent prostate cancer cell proliferation. In addition, 17beta-estradiol prevents bone loss, and suppresses andropause symptoms, such as hot flashes, which appear during androgen-deprivation therapy (ADT) where the standard of care is the use of gonadotrophin releasing hormone (GnRH) analogs. Compared to oral estrogens, the topical gel formulation lowers the risk of cardiovascular side effects." + }, + { + "input": "Concept: 1,4-Butanediamine, N-(3-aminopropyl)- (Simple organic compound)", + "output": "Amine and amine derivative described as a polyamine formed from putrescine. It is found in almost all tissues in association with nucleic acids. It is found as a cation at all pH values, and is thought to help stabilize some membranes and nucleic acid structures. It is a precursor of spermine." + }, + { + "input": "Concept: Non-hollow viscus (Viscera)", + "output": "Body Part, Organ, or Organ Component described as viscus, some organ parts of which constitute lobes, segments, lobules, acini, or cortex and medulla. Examples: thymus, pancreas, kidney, ovary." + }, + { + "input": "Concept: CSS10-Number of Aborted Attempts-P3M (C-SSRS Pediatric Cognitively Impaired Lifetime Recent Questionnaire Question)", + "output": "Intellectual Product described as columbia-Suicide Severity Rating Scale Pediatric/Cognitively Impaired Lifetime/Recent - Total number of aborted or self-interrupted attempts. (Past 3 Months)." + }, + { + "input": "Concept: juvenile idiopathic arthritis, oligoarticular (Juvenile arthritis)", + "output": "Juvenile arthritis described as a category of juvenile idiopathic arthritis defined by the presence of arthritis affecting between one and four separate joints during the first six months of disease." + }, + { + "input": "Concept: ANTIGEN, B. PERTUSSIS (Indicator, Reagent, or Diagnostic Aid)", + "output": "something described as bordetella spp. serological reagents are devices that consist of antigens and antisera, including antisera conjugated with a fluorescent dye, used in serological tests to identify Bordetella spp. from cultured isolates or directly from clinical specimens. The identification aids in the diagnosis of diseases caused by bacteria belonging to the genus Bordetella and provides epidemiological information on these diseases. Bordetella spp. cause whooping cough (Bordetella pertussis) and other similiarly contagious and acute respiratory infections characterized by pneumonitis (inflammation of the lungs)." + }, + { + "input": "Concept: U1 snRNA 3' end processing (snRNA 3'-end processing)", + "output": "Genetic Function described as any process involved in forming the mature 3' end of a U1 snRNA molecule." + }, + { + "input": "Concept: NONSUSCEPTIBLE (ObservationInterpretationSusceptibility)", + "output": "ObservationInterpretationSusceptibility described as a microbial susceptibility test result in which the growth of microorganisms is not inhibited by the usually achievable concentrations of antimicrobial agent when the recommended dosage is used for the site of infection. This category may be applied to new antimicrobial agents for which no resistant microorganisms have been encountered at the time the initial interpretive criteria are determined. Microorganisms that test with an MIC above or a zone measurement below the susceptible interpretive criteria may be designated as nonsusceptible. A designation of nonsusceptible does not necessarily mean that a resistance mechanism(s) exists in the microorganism." + }, + { + "input": "Concept: GASTRIC BYPASS (Bypass graft)", + "output": "something described as surgical procedure in which the STOMACH is transected high on the body. The resulting small proximal gastric pouch is joined to any parts of the SMALL INTESTINE by an end-to-side SURGICAL ANASTOMOSIS, depending on the amounts of intestinal surface being bypasses. This procedure is used frequently in the treatment of MORBID OBESITY by limiting the size of functional STOMACH, food intake, and food absorption." + }, + { + "input": "Concept: Retinoblastoma cNX TNM Finding v7 (Finding)", + "output": "Finding described as retinoblastoma in which the regional lymph nodes cannot be assessed." + }, + { + "input": "Concept: DESLORELIN ACETATE (Pharmacologic Substance)", + "output": "Luteinizing Hormone-releasing Hormone Agonist described as a synthetic nonapeptide analogue of the natural gonadotrophin releasing hormone (GnRH) with potential antineoplastic activity. Deslorelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Continuous, prolonged administration of goserelin in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C82600\" active clinical trials using this agent." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, F13B (Medical Device)", + "output": "something described as molecular assay reagents intended to identify mutations in the coagulation factor XIII B chain (F13B) gene, located at chromosome 1q31-q32.1, which encodes the protein coagulation factor XIII B chain. Genetic variants at this locus have been associated with factor XIII B subunit deficiency." + }, + { + "input": "Concept: Aspirator/Irrigators, Surgical (Aspirator/Irrigators)", + "output": "Aspirator/Irrigators described as aspirators/irrigators designed for automated or semiautomated irrigation, washing, and evacuation of debris from the surgical site. These devices typically consist of an electromechanical main unit that usually includes a pump for irrigation/infusion of liquids (e.g., saline), an extractor (frequently using vacuum), and controls for the rate of irrigation/infusion and withdrawal of the liquid; surgical aspiration/irrigation units are usually coupled to handpieces that may include the irrigation/suction controls. A set of dedicated detachable tips and other accessories for particular surgical applications are also available. Surgical lavage units are intended for use in surgical rooms and in doctors' offices during minor surgical procedures. Dedicated surgical irrigators/aspirators intended for endoscopic and laparoscopic procedures are also available." + }, + { + "input": "Concept: Brugada Syndrome Pattern by ECG Finding (Finding)", + "output": "something described as an electrocardiographic finding of complete or incomplete right bundle branch block accompanied by ST elevation in leads V1-V3. This may be noted at rest or can be provoked by medication challenge." + }, + { + "input": "Concept: Striae skin (Atrophic)", + "output": "Lack of skin elasticity described as linear dermal scars accompanied by epidermal atrophy that affects skin that is subjected to continuous stretching. They usually do not cause any significant medical problems, only cosmetic problems." + }, + { + "input": "Concept: Emergency Medicine Administration Procedure Kit/Trays (Medical Device)", + "output": "something described as prepackaged collections of the devices and supplies (i.e., either custom or standard kits) needed for initial emergency medicine administration. Items in these kits usually include syringes and antiseptic bandages, gauze, and swabs; they may also include vials with basic emergency drugs such as amyl nitrite, ammonia, atropine, epinephrine, aminophylline, aspirin, glucose, and antihistamines. The kits are frequently supplied in supporting trays (i.e., procedure trays) consisting of a flat-bottomed receptacle with a border around the periphery supporting all the instruments and supplies needed for the procedure; the trays are usually covered or wrapped. Medicine administration emergency procedure kits and trays are intended for use in the quick and effective treatment of common patient emergencies including those related to angina, asthma, diabetes, allergic reactions, fainting, and heart attacks. They are used in the field, at home, in emergency rooms, and in other areas of healthcare facilities." + }, + { + "input": "Concept: Posterior Tibial Artery Branch (Structure of posterior tibial artery)", + "output": "something described as any artery arising from the posterior tibial artery." + }, + { + "input": "Concept: microRNA 214 (MicroRNA Gene)", + "output": "MicroRNA Gene described as this gene is involved in the regulation of gene expression and plays a role in the development of ovarian carcinoma." + }, + { + "input": "Concept: PATHRESP (Disease Response)", + "output": "something described as an evaluation of the pathologic response of the disease to the therapy." + }, + { + "input": "Concept: Neurologist 1 (Professional or Occupational Group)", + "output": "something described as a neurologist performing the assessment that is given the designation of one." + }, + { + "input": "Concept: Abnormal morphology of the cerebellar cortex (Abnormality of the cerebellum)", + "output": "Anatomical Abnormality described as any structural anomaly of the cortex of the cerebellum. []" + }, + { + "input": "Concept: male germ-line sex determination (primary sex determination, germ-line)", + "output": "Organ or Tissue Function described as the determination of sex and sexual phenotype in a male organism's germ line." + }, + { + "input": "Concept: Difficult none of the time (Clinical or Research Assessment Answer)", + "output": "Finding described as a response indicating that something is or was difficult none of the time." + }, + { + "input": "Concept: Swim Gently (Intellectual Product)", + "output": "Intellectual Product described as a question about whether an individual did any gentle swimming." + }, + { + "input": "Concept: Calcification Indicator (Indicator)", + "output": "something described as an indication as to whether calcification is present." + }, + { + "input": "Concept: Cefiximum (C [Preparations])", + "output": "something described as a broad-spectrum, third-generation cephalosporin antibiotic derived semisynthetically from the marine fungus Cephalosporium acremonium with antibacterial activity. As does penicillin, the beta-lactam antibiotic cefixime inhibits bacterial cell wall synthesis by disrupting peptidoglycan synthesis, resulting in a reduction in bacterial cell wall stability and bacterial cell lysis. Stable in the presence of a variety of beta-lactamases, this agent is more active against gram-negative bacteria and less active against gram-positive bacteria compared to second-generation cephalosporins." + }, + { + "input": "Concept: Anatomical compartment (Anatomical space structure)", + "output": "something described as anatomical space, which is surrounded by subdivisions of two or more organs, it contains two or more organs or organ subdivisions that are members of two or more organ subclasses. Examples: mediastinum, anterior compartment of forearm, palm of hand(compartment), intercostal space, vertebral canal" + }, + { + "input": "Concept: Transplacental (Functional Concept)", + "output": "RouteBySite described as in utero exposure of an embryo/foetus to a medicinal product administered to the pregnant mother. Comment: This term is not intended to describe an authorised route of administration for use in marketing authorisations, and does not cover intentional administration of a medicinal product to an embryo/foetus. It is intended for use in adverse event reporting for pharmacovigilance purposes." + }, + { + "input": "Concept: monodemethylisoproturon dimethylaminedehydrogenase activity (oxidoreductase activity, acting on the CH-NH group of donors)", + "output": "something described as catalysis of the reaction: monodemethylisoproturon + H2O = didemethylisoproturon + formaldehyde + 2 H+ + 2 e-." + }, + { + "input": "Concept: TEEN PREGN (Pregnancy)", + "output": "Finding of pattern of pregnancy described as a pregnancy in an adolescent between the ages of thirteen and nineteen." + }, + { + "input": "Concept: Corynebacterium pilosum Yanagawa and Honda 1978 (Corynebacterium)", + "output": "something described as a species of aerobic or facultatively anaerobic, Gram-positive, coryneform, pleomorphic bacilli assigned to the phylum Actinobacteria. This species is nonmotile, non-spore forming, catalase and urease positive, oxidase and indole negative, reduces nitrate and nitrite, hydrolyzes hippurate and starch, but not gelatin or casein, and does not produce hydrogen sulfide. C. pilosum causes urinary tract infection and pyelonephritis." + }, + { + "input": "Concept: Mycobacterium chelonae subsp. abscessus (Rapid growing mycobacteria)", + "output": "Rapid growing mycobacteria described as any bacterial organism that can be assigned to the species Mycobacterium abscessus." + }, + { + "input": "Concept: P621 (Transcription Regulatory Protein)", + "output": "Transcription Regulatory Protein described as activating transcription factor 7-interacting protein 1 (1270 aa, ~136 kDa) is encoded by the human ATF7IP gene. This protein is involved in both transcriptional regulation and histone methylation." + }, + { + "input": "Concept: fos Proto-Oncogene Proteins (Biologically Active Substance)", + "output": "Basic-Leucine Zipper Transcription Factors described as cellular DNA-binding proteins encoded by the c-fos genes (GENES, FOS). They are involved in growth-related transcriptional control. c-fos combines with c-jun (PROTO-ONCOGENE PROTEINS C-JUN) to form a c-fos/c-jun heterodimer (TRANSCRIPTION FACTOR AP-1) that binds to the TRE (TPA-responsive element) in promoters of certain genes." + }, + { + "input": "Concept: neoplasm vulva (Female reproductive neoplasms unspecified malignancy)", + "output": "Mass of female genital structure described as a benign or malignant neoplasm that affects the vulva. Representative examples include Bartholin gland adenoma, vulvar nodular hidradenoma, vulvar carcinoma, and vulvar melanoma." + }, + { + "input": "Concept: microtubule anchoring at centrosome (microtubule anchoring at microtubule organizing center)", + "output": "Cell Function described as any process in which a microtubule is maintained in a specific location in a cell by attachment to a centrosome." + }, + { + "input": "Concept: 3' Amino 3' deoxy N,N dimethyladenosine (Deoxyadenosines)", + "output": "Deoxyadenosines described as PUROMYCIN derivative that lacks the methoxyphenylalanyl group on the amine of the sugar ring. It is an antibiotic with antineoplastic properties and can cause nephrosis." + }, + { + "input": "Concept: Testicular Non-Seminomatous Germ Cell Tumor (Nongerminomatous Germ Cell Tumor)", + "output": "Nongerminomatous Germ Cell Tumor described as a testicular germ cell tumor characterized by the absence of a seminomatous component. It includes embryonal carcinoma, yolk sac tumor, choriocarcinoma, teratoma, and mixed forms." + }, + { + "input": "Concept: Lozenge Dosage Form Category (Basic Dosage Form Category)", + "output": "Basic Dosage Form Category described as a type of solid pharmaceutical dose form consisting of a hard mass formed by moulding or compression, intended to dissolve or disintegrate slowly in the oral cavity when sucked." + }, + { + "input": "Concept: Radius Gauges, Contact Lens (Ophthalmological Equipment and Supplies)", + "output": "something described as devices used to measure the radius or curvature of hard contact lenses." + }, + { + "input": "Concept: ioxaglic acid (Triiodobenzoic Acids)", + "output": "Indicator, Reagent, or Diagnostic Aid described as a low-osmolar, ionic contrast medium used in various radiographic procedures." + }, + { + "input": "Concept: familial spastic paraplegia autosomal recessive type 44 (Complicated hereditary spastic paraplegia)", + "output": "Spastic paraplegia type 5A, recessive described as a very rare, complex form of hereditary spastic paraplegia characterized by a late-onset, slowly progressive spastic paraplegia associated with mild ataxia and dysarthria, upper extremity involvement (i.e. loss of finger dexterity, dysmetria), and mild cognitive impairment, without the presence of nystagmus. A hypomyelinating leukodystrophy and thin corpus callosum is observed in all cases and psychomotor development is normal or near normal. Caused by mutations in the GJC2 gene (1q41-q42) encoding the gap junction gamma-2 protein." + }, + { + "input": "Concept: Birth Intervals (Temporal Concept)", + "output": "something described as the lengths of intervals between births to women in the population." + }, + { + "input": "Concept: Heat Stress Response (Physiologic Function)", + "output": "Homeostasis described as a constellation of responses that occur when an organism is exposed to excessive heat and other environmental stresses. Responses include synthesis of some proteins, repression of other proteins, and expression of new proteins." + }, + { + "input": "Concept: Infections, Puerperal (Female reproductive tract infections)", + "output": "Puerperal Disorders described as an infection occurring in PUERPERIUM, the period of 6-8 weeks after giving birth." + }, + { + "input": "Concept: 3,5-dichlorophenylcarboximide hydrolase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides)", + "output": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides described as catalysis of the reaction: 3,5-dichlorophenylcarboximide + OH- = (3,5-dichlorophenylurea)acetate." + }, + { + "input": "Concept: negative regulation of protein degradation (Cell Function)", + "output": "negative regulation of protein metabolic process described as any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." + }, + { + "input": "Concept: Tumour of pharynx (Head and Neck Neoplasms)", + "output": "neoplasm of pharynx location described as a benign or malignant neoplasm that affects the nasopharynx, oropharynx, or hypopharynx." + }, + { + "input": "Concept: MAPKK2 Gene Rearrangement (Gene Rearrangement Abnormality)", + "output": "something described as a molecular abnormality indicating rearrangement of the MAP2K2 gene." + }, + { + "input": "Concept: Recurrent Non-Muscle Invasive Bladder Urothelial Carcinoma with a Prior History of Low or Intermediate Risk Non-Muscle Invasive Bladder Urothelial Carcinoma (Neoplastic Process)", + "output": "Urinary system finding described as a finding indicating the reemergence of non-muscle invasive bladder urothelial carcinoma after a period of remission, in patients with a prior history of low or intermediate risk non-muscle invasive bladder urothelial carcinoma." + }, + { + "input": "Concept: CSS06TN (Intellectual Product)", + "output": "CDISC Questionnaire Terminology described as test names of questionnaire questions associated with the Columbia-Suicide Severity Rating Scale Children's Baseline (C-SSRS Children's Baseline) for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: Other Pacific Islander (Population Group)", + "output": "something described as a person having origins in the original peoples of the Pacific Islands, but not Guam, Hawaii, the Mariana Islands or Samoa." + }, + { + "input": "Concept: OSMLTY (Laboratory Procedure)", + "output": "Optical density measurement described as the determination of the osmoles of solute per kilogram of solvent present in a sample." + }, + { + "input": "Concept: Nitella C.Agardh, 1824 (Characeae)", + "output": "something described as a genus of green plants in the family CHARACEAE, phylum STREPTOPHYTA. They are found in shallow to deep waters of soft water or acid lakes and bogs." + }, + { + "input": "Concept: Grade 4 Typhlitis (Finding)", + "output": "Finding described as life-threatening consequences; urgent operative intervention indicated" + }, + { + "input": "Concept: Golgi cis cisterna (Golgi cisternae)", + "output": "something described as the Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER." + }, + { + "input": "Concept: Papillary, Follicular, Hurthle Cell, Poorly Differentiated, and Anaplastic Thyroid Carcinoma pT2 TNM Finding v8 (Finding)", + "output": "something described as tumor measuring more than 2 cm but 4 cm or less in greatest dimension limited to the thyroid." + }, + { + "input": "Concept: Bachelor of Science in Nursing (Degree/license/certificate)", + "output": "Intellectual Product described as a four year academic degree in the science and principles of nursing, granted by a tertiary education university or similarly accredited school." + }, + { + "input": "Concept: Indian Mulberry (M [Preparations])", + "output": "Organic Chemical described as a shrub or small tree in the family Rubiaceae. Morinda citrifolia is native to Southeast Asia but has been extensively spread by man throughout India and into the Pacific islands as far as the French Polynesian Islands. It grows in shady forests as well as on open rocky or sandy shores. It is tolerant of saline soils, drought conditions, and secondary soils. It therefore found in a wide variety of habitats: volcanic terrains, lava-strewn coasts, and clearings or limestone outcrops. It can grow up to 9 m tall, and has large, simple, dark green, shiny and deeply veined leaves. The plant flowers and fruits all year round. The flowers are small and white. The fruit is a multiple fruit that has a pungent odor when ripening, and is hence also known as cheese fruit or even vomit fruit. It is oval and reaches 4-7 cm in size." + }, + { + "input": "Concept: Pili torti with developmental delay and neurological abnormality syndrome (Multiple system malformation syndrome)", + "output": "Disease or Syndrome described as this syndrome has characteristics of growth and developmental delay, mild to moderate neurologic abnormalities, and pili torti. It has been described in a brother and his sister born to consanguineous Puerto Rican parents." + }, + { + "input": "Concept: Guttate parapsoriasis (Rare Non-Neoplastic Disorder)", + "output": "Rare Non-Neoplastic Disorder described as a subgroup of PARAPSORIASIS itself divided into acute and chronic forms. The acute form is characterized by the abrupt onset of a generalized, reddish-brown, maculopapular eruption. Lesions may be vesicular, hemorrhagic, crusted, or necrotic. Histologically the disease is characterized by epidermal necrolysis. The chronic form shows milder skin changes with necrosis." + }, + { + "input": "Concept: Pancreatic Macrocystic Serous Cystadenoma (Cystadenoma of pancreas)", + "output": "Pancreatic Serous Adenoma described as a benign, non-metastasizing epithelial neoplasm arising from the exocrine pancreas. It is characterized by the presence of a few large cysts and is composed of glycogen-rich epithelial cells which produce a watery fluid." + }, + { + "input": "Concept: PQL0518 (Intellectual Product)", + "output": "Intellectual Product described as pediatric Quality of Life Neuromuscular Module Version 3 Child - In the past one month, how much of a problem has this been for you: It is hard for me to tell the doctors and nurses how I feel." + }, + { + "input": "Concept: up-regulation of coated pit assembly (positive regulation of cellular component biogenesis)", + "output": "regulation of clathrin-coated pit assembly described as any process that activates or increases the frequency, rate or extent of clathrin-coated pit assembly." + }, + { + "input": "Concept: newspaper article (Newspapers)", + "output": "Publication Formats described as work consisting of a news item appearing in a general-interest newspaper or other general news periodical, containing information of current and timely interest in the field of medicine or science. This publication type should not be confused with NEWS Publication Type, reserved for news reports published in various medical or other scientific journals, such as \"Nature\"." + }, + { + "input": "Concept: Human Complement for Hamster Temperature-Sensitive Mutant ts11 Gene (Gene or Genome)", + "output": "ASNS gene described as human ASNS wild-type allele is located in the vicinity of 7q21.3 and is approximately 20 kb in length. This allele, which encodes asparagine synthetase [glutamine-hydrolyzing] protein, plays a role in amino acid conversion. A fusion involving this gene and the KMT2E gene may be associated with early T-cell precursor acute lymphoblastic leukemia (ETP-ALL)." + }, + { + "input": "Concept: Eicosanoic acid (Saturated fat)", + "output": "Fatty Acids described as saturated fatty acid with 20 carbons." + }, + { + "input": "Concept: Anterior Kidneys (Pronephric structure)", + "output": "something described as a primitive form of vertebrate kidney that is found in adults of some primitive FISHES and in the embryos of more advanced fishes. In some species of fishes it contains phagocytic cells and is also a major site of HEMATOPOIESIS, analogous to the mammalian BONE MARROW." + }, + { + "input": "Concept: Shiga-Toxigenic Escherichia coli (Escherichia coli)", + "output": "something described as strains of ESCHERICHIA COLI with the ability to produce at least one or more of at least two antigenically distinct, usually bacteriophage-mediated cytotoxins: SHIGA TOXIN 1 and SHIGA TOXIN 2. These bacteria can cause severe disease in humans including bloody DIARRHEA and HEMOLYTIC UREMIC SYNDROME." + }, + { + "input": "Concept: FKH1 Fusion Positive (Laboratory or Test Result)", + "output": "Rearrangement Detected described as an indication that expression of a fusion containing sequences from FOXO1 has been detected in a sample." + }, + { + "input": "Concept: acetyl-l-carnitine (Dietary Supplements)", + "output": "something described as a form of the natural substance carnitine that is being studied as a way to prevent tissue damage caused by chemotherapy. Carnitine is made in muscle and liver tissue and is found in certain foods, such as meat, poultry, fish, and some dairy products. It is used by many cells in the body to make energy from fat." + }, + { + "input": "Concept: X-linked intellectual disability Stocco Dos Santos type (Disease or Syndrome)", + "output": "Intellectual Disability described as this syndrome is characterized by severe intellectual deficit with hyperactivity, language delay, congenital hip luxation, short stature, kyphosis and recurrent respiratory infections. Aggressive behavior and frequent epileptic seizures may also be present. The syndrome has been described in four boys from the same family. Transmission is X-linked and is caused by mutations in the KIAA1202 gene, localized to the Xp11.2 region." + }, + { + "input": "Concept: FAC00612 (FACT-BL Version 4 Questionnaire Question)", + "output": "something described as functional Assessment of Cancer Therapy-Bladder Version 4 - Social/Family Well-Being: I am satisfied with family communication about my illness." + }, + { + "input": "Concept: mbIL21-expanded haploidentical NK cells (Cell)", + "output": "Cell described as a preparation of human cytokine interleukin-21 (IL-21) primed, tumor-activated allogeneic human leukocyte antigen (HLA) haploidentical natural killer (NK) cells, with potential cytolytic and immunoregulatory activities. Allogeneic leukemia cells are genetically modified to express membrane-bound interleukin-21 (mbIL-21) on their cell surfaces. When human peripheral blood mononuclear cells (PBMCs) from an HLA-haploidentical donor are subsequently exposed to these cells, the donor PBMC differentiate into mature, highly cytotoxic NK cells, which are subsequently expanded in ex vivo culture. Upon infusion of the mbIL-21-expanded haploidentical NK cells, the NK cells target, lyse and destroy tumor cells. mbIL-21 promotes sustained ex vivo proliferation of human NK cells and enhances its cytotoxic activity." + }, + { + "input": "Concept: hypospadias; perineal (Congenital Abnormality)", + "output": "Congenital Abnormality described as hypospadias with location of the urethral meatus in the perineal region." + }, + { + "input": "Concept: Postdoctoral Individual National Research Service Award (Governmental or Regulatory Activity)", + "output": "Governmental or Regulatory Activity described as to provide support to promising Fellowship Applicants with the potential to become productive, independent investigators in scientific health-related research fields relevant to the missions of participating NIH Institutes and Centers." + }, + { + "input": "Concept: benzo(a)pyrene 9,10-dioxygenase activity (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)", + "output": "Molecular Function described as catalysis of the reaction: benzo(a)pyrene + O2 = benzo(a)pyrene-cis-9,10-dihydrodiol." + }, + { + "input": "Concept: Brucea javanica / ya dan zi (Plant)", + "output": "Plant described as ya dan zi" + }, + { + "input": "Concept: Have you experienced firmness / tightness (Intellectual Product)", + "output": "Findings-Based Question described as a question about whether an individual has or had firmness or tightness." + }, + { + "input": "Concept: FAC01811 (FACT-LYM Version 4 Questionnaire Question)", + "output": "something described as functional Assessment of Cancer Therapy-Lymphoma Version 4 (FACT-LYM Version 4) Social/Family Well-Being: My family has accepted my illness." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Immunoassay, Endocrine Hormone, Serotonin (Medical Device)", + "output": "something described as immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (typically serum) to determine serotonin, a hormone that is a derivative of the amino acid tryptophan; it is transported in the blood by the platelets. Serotonin (5-hydroxytryptamine [5-HT]) is a neuron transmitter within the brain, with a marked influence on sleep, pain perception, social behavior, and depression. Low levels of serotonin are associated with some depressed patients (i.e., serotonin-deficient patients). High-pressure liquid chromatography assays are most widely used for determination of serotonin." + }, + { + "input": "Concept: bed nuclei stria terminalis, anterior division, rhomboid nucleus (anterior nuclei of stria terminalis)", + "output": "Body Part, Organ, or Organ Component described as a component of the nuclei of stria terminalis defined on the basis of topology, connectivity and multiple stains in the rat. It is one of nine components of the anterior nuclei of stria terminalis in the Functional CNS Model - Rat ( Swanson-2004 )." + }, + { + "input": "Concept: Global Alignment of Immunization safety Assessment in pregnancy Preterm Birth Level of Diagnostic Certainty (GAIA Neonatal Case Definitions)", + "output": "Intellectual Product described as a classification of maternal and fetal outcomes relating to preterm birth, developed by the Global Alignment of Immunization safety Assessment in pregnancy, based on the extent to which the diagnosis has been confirmed." + }, + { + "input": "Concept: Stage II Diffuse Mixed Cell Lymphoma (Adult Diffuse Mixed Cell Lymphoma)", + "output": "something described as stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C8121\" active clinical trials using this agent." + }, + { + "input": "Concept: chemotherapeutics growth-signaling inhibitors dacomitinib (Protein-tyrosine kinase inhibitor)", + "output": "Molecular Target Inhibitors described as an orally bioavailable, highly selective, second-generation small-molecule inhibitor of the pan-epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR-expressing tumor cells. EGFRs play major roles in tumor cell proliferation and tumor vascularization, and are often overexpressed or mutated in various tumor cell types. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C53398\" active clinical trials using this agent." + }, + { + "input": "Concept: hla dr (HLA-D Antigens)", + "output": "Histocompatibility Antigens Class II described as encoded by multiple HLA-DRA and HLA-DRB genes in a complex variable 5 cM region of MHC between HLA-B and -D, HLA-DR Antigens are Class II histocompatibility transmembrane glycoprotein heterodimers of alpha (heavy, 35-kD) and beta (light, 27-kD) chains. Located predominantly on B cells and macrophages, HLA-DR antigens function in antigen presentation to regulatory T cells in the immune response and in self/nonself discrimination. Invariant alpha and polymorphic beta chains have glycosylated N-termini, hydrophobic membrane regions, and hydrophilic C-termini. The heterodimer consists of 4 extracellular domains; invariant alpha-1, polymorphic N-terminal beta-1, and conserved Ig-like alpha-2 and beta-2. Alpha-1 and alpha-2 contain disulfide loops. Beta-1 contains 2 small variable regions. Alpha sequences have relatively simple structure; beta chains carry the major polymorphic determinants." + }, + { + "input": "Concept: Exposure as Collected Start Date and Time of Treatment (Temporal Concept)", + "output": "something described as the date and time of the beginning of exposure collection period." + }, + { + "input": "Concept: Disposable Food Trays (General hospital device)", + "output": "Food Trays described as trays designed for single use to hold, separate, carry or serve food. These trays are used once and then discarded; they can be made of plastic, paper, foam or cardboard. Disposable food trays can come in varied shapes and sizes to serve different needs. They may be divided into several sections and may have built-in handles. Food trays are mainly used in healthcare facilities by inpatients, visitors and staff; they are also used for in-home care." + }, + { + "input": "Concept: cytidylyltransferase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the transfer of a cytidylyl group to an acceptor." + }, + { + "input": "Concept: necrosis of soft tissue of head (Pathologic Function)", + "output": "Head and Neck Necrotic Lesion described as a necrotic process affecting the soft tissues of the head." + }, + { + "input": "Concept: Diploic space of bone of cranial vault (Tissue space)", + "output": "Body Space or Junction described as tissue space in trabecular bone of cranial bone and which contains bone marrow." + }, + { + "input": "Concept: Groundhog (Rodent)", + "output": "Rodent described as a burrowing rodent of the family Sciuridae, belonging to the group of large ground squirrels known as marmots. The woodchuck model of viral-induced hepatocellular carcinoma (HCC) provides an animal model that resembles the complex human liver environment of HCC in the context of chronic hepatitis B viral infection." + }, + { + "input": "Concept: BURKHOLD (Laboratory Procedure)", + "output": "something described as a measurement of the organisms that are not assigned to the species level but are assigned to the Burkholderia genus level in a biological specimen." + }, + { + "input": "Concept: Translations (Publications)", + "output": "Action described as the act or process of rendering from one language into another." + }, + { + "input": "Concept: maekmoondong-tang (Organic Chemical)", + "output": "Antitussive Agents described as a traditional East Asian herbal medicine composed of six herbs, including Ophiopogonis tuber, Pinelliae tuber, Glycyrrhizae radix, Zizyphi fructus, Ginseng radix, and Oryzae semen, with potential anti-tussive activity. Maekmoondong-tang is traditionally prescribed for respiratory symptoms to direct the qi downwards and compensate for lung-yin deficiency or dry lung by tonifying yin and moistening the lung. Although the exact mechanisms through which Maekmoondong-tang exerts its effects have yet to be fully elucidated, this agent may, upon administration, improve the severity of chronic cough, reduce airway hyper-responsiveness possibly by reducing the cough reflex and bronchodilation, and airway inflammation possibly through anti-inflammatory and immunomodulatory effects." + }, + { + "input": "Concept: Amputations, Traumatic (Non-site specific injuries NEC)", + "output": "something described as loss of a limb or other bodily appendage by accidental injury." + }, + { + "input": "Concept: Testicular microlithiasis (Male internal genital organ)", + "output": "Calculus finding described as the deposition of calcium phosphate microliths within the seminiferous tubules." + }, + { + "input": "Concept: positive regulation of translation initiation in response to endoplasmic reticulum stress (positive regulation of translational initiation in response to stress)", + "output": "regulation of translation initiation in response to endoplasmic reticulum stress described as any process that activates, or increases the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress." + }, + { + "input": "Concept: BEPHENIUM CPDS (Organic Chemical)", + "output": "something described as analogs or derivatives of bephenium (N,N-dimethyl-N-(2-phenoxyethyl)benzenemethanaminium)." + }, + { + "input": "Concept: Cenani syndactylism (Multiple malformation syndrome with limb defect as major feature)", + "output": "something described as a congenital malformation syndrome that associates a complex syndactyly of the hands with malformations of the forearm bones and similar manifestations in the lower limbs. Fewer than 30 cases have been described, the majority of cases occurred in related families. The syndrome affects both the upper and lower limbs but, in general, the latter are less severely affected. Associated malformations (renal hypoplasia and vertebral and hemi-vertebral anomalies) have occasionally been reported. Mild facial dysmorphism has been described in isolated cases. The disease is transmitted as an autosomal recessive trait. Homozygous or compound heterozygous mutations of the LRP4 gene (11p12-p11.2) have been identified." + }, + { + "input": "Concept: protein maturation by protein folding (protein folding)", + "output": "Molecular Function described as the process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that results in the attainment of the full functional capacity of a protein." + }, + { + "input": "Concept: Hepatopancreas (Body Part, Organ, or Organ Component)", + "output": "something described as a primitive form of digestive gland found in marine ARTHROPODS, that contains cells similar to those found in the mammalian liver (HEPATOCYTES), and the PANCREAS." + }, + { + "input": "Concept: Golgi transport complex binding (protein-containing complex binding)", + "output": "something described as interacting selectively and non-covalently with the Golgi transport complex, a multisubunit tethering complex of the CATCHR family." + }, + { + "input": "Concept: TSF (Pharmacologic Substance)", + "output": "something described as any recombinant analog of endogenous interleukin-2 (IL-2), a cytokine involved in intercellular communication related to cell differentiation, proliferation, inflammation, hematopoiesis, neuronal functions, and release of hormones. IL-2 binds to and activates specific receptors, triggering expression of specific genes, and may induce T cell-mediated tumor regression in some tumor types." + }, + { + "input": "Concept: 5 Hydroxytryptamine Plasma Membrane Transport Protein (Symporters)", + "output": "Plasma Membrane Neurotransmitter Transport Proteins described as responsible for accumulation of serotonin in peripheral blood cells, placenta, and lungs." + }, + { + "input": "Concept: Gallbladder MANEC (Gallbladder Carcinoma)", + "output": "Neoplastic Process described as a carcinoma that arises from the gallbladder and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component. At least 30 percent of either component should be present for the diagnosis to be made." + }, + { + "input": "Concept: Conversion of Alanine, Glycine, Serine, Cysteine, Tryptophan, and Threonine into Pyruvate (Functional Concept)", + "output": "Amino Acid Metabolism Pathway described as amino acids in the diet have one of two fates - either they are incorporated into proteins or they are broken down for energy and metabolic intermediates. They are not stored and the body also does not excrete them intact. The metabolic pathways that lead to degradation of amino acids funnel their carbon chains into metabolic intermediates that generate energy, and their amino groups into the urea cycle to be excreted. The amino acids alanine, glycine, serine, cysteine, tryptophan and threonine all have a common endpoint, the metabolic intermediate pyruvate. Threonine is converted to glycine through the removal of an acetaldehyde group, and glycine is then converted to serine, then pyruvate. More than one path can remove the sulfur and nitrogen groups of serine to create pyruvate. Part of tryptophan is found in alanine, which is converted directly to pyruvate through transamination. The removal of amino nitrogens commonly occurs through transamination, transferring the nitrogen to alpha-ketobutyrate to create glutamate. All of these amino acids are termed glucogenic since the pyruvate resulting from their metabolism can enter gluconeogenesis to create glucose. Pyruvate can also be converted by pyruvate dehydrogenase into acetyl-CoA, which can enter into the Kreb's cycle to generate ATP, be converted to ketone bodies, or be directed into fatty acid biosynthesis. The importance of amino acid degradation is demonstrated by a genetic defect in serine hydroxymethyl transferase. In individuals with this condition, glycine accumulates to toxic levels in the body due to a lack of other mechanisms of metabolism." + }, + { + "input": "Concept: luteolin biosynthetic process (Molecular Function)", + "output": "Molecular Function described as the chemical reactions and pathways resulting in the formation of luteolin, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one." + }, + { + "input": "Concept: Film, Xray (Medical Device)", + "output": "Diagnostic imaging equipment described as radiographic film is a device that consists of a thin sheet of radiotransparent material coated on one or both sides with a photographic emulsion intended to record images during diagnostic radiologic procedures." + }, + { + "input": "Concept: Nasopharyngeal Cancer pTis TNM Finding v7 (Finding)", + "output": "Finding described as nasopharyngeal cancer with a finding of carcinoma in situ." + }, + { + "input": "Concept: NCI CTEP SDC CNS-excluded Nervous System Neoplasm, Miscellaneous Sub-Category Terminology (NCI CTEP SDC CNS-excluded Nervous System Neoplasm and Disorder Category Terminology)", + "output": "something described as CNS-excluded Nervous System Neoplasm, Miscellaneous is an NCI Cancer Therapeutic Evaluation Program (CTEP) Simplified Disease Classification (SDC) category used to organize cancer-related disease coding that harmonizes with and supports reporting based on the global standard Medical Dictionary for Drug Regulatory Reporting (MedDRA) terminology." + }, + { + "input": "Concept: autologous P-BCMA-101 CAR-T cells (Antineoplastic Immune Cell)", + "output": "Chimeric Antigen Receptor T-cells described as a preparation consisting of autologous T-cells that are enriched to be primarily stem memory T-cells (Tscm) and are transfected by electroporation with a proprietary transposon-based DNA plasmid vector (PiggyBac) containing an undisclosed selection gene and encoding both an unidentified human-derived safety switch and a chimeric antigen receptor (CAR) based on a proprietary non-immunoglobulin scaffold molecule Centyrin (CARTyrin), which specifically recognizes human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-BCMA-CAR-expressing Tscm P-BCMA-101 specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. Use of CARTyrin may elicit less immunotoxicity than agents based on antibody-derived single chain variable fragments (scFv), and this agent may exhibit increased persistence and decreased exhaustion for the administered T-cells. If significant side effects occur, the safety switch mechanism can induce the rapid attenuation or elimination of P-BCMA-101. BCMA, a tumor-specific antigen and a member of the tumor necrosis factor receptor superfamily (TNFRSF) that binds to both a proliferation-inducing ligand (APRIL; TNFSF13) and B-cell activating factor (BAFF; TNFSF13B), plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and is overexpressed on malignant plasma cells." + }, + { + "input": "Concept: Sensory Function: Tactile (Esthesia)", + "output": "Esthesia described as ability to correctly sense stimulation of the skin" + }, + { + "input": "Concept: Unsaturated fat (Fat and oil)", + "output": "Fat and oil described as fats containing one or more double bonds, as from oleic acid, an unsaturated fatty acid." + }, + { + "input": "Concept: Tubularization of Bowman capsule (Anatomical Abnormality)", + "output": "Abnormal morphology of Bowman capsule described as the presence of cuboidal to columnar epithelium (height greater than width) lining the Bowman capsule, in an absence of adjacent segmental sclerosis, crescents, or collapsing variant of focal segmental glomerulosclerosis; scored as present or absent in at least one glomerulus." + }, + { + "input": "Concept: Grade 3 Persistent Pulmonary Hypertension of the Newborn (Persistent Pulmonary Hypertension of the Newborn, Adverse Event)", + "output": "Finding described as increased estimated RV-pressures; with severe clinical symptoms; oxygenation index >25; major care changes required (e.g. iNO)." + }, + { + "input": "Concept: Ovarian Cancer and Primary Peritoneal Carcinoma pT0 TNM Finding v7 (Finding)", + "output": "something described as ovarian cancer or primary peritoneal carcinoma with no evidence of primary tumor." + }, + { + "input": "Concept: lamellipodium assembly involved in mesendodermal cell migration (Cell Function)", + "output": "something described as formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self-propelled movement of a mesendodermal cell." + }, + { + "input": "Concept: FGF19 (Laboratory Procedure)", + "output": "something described as a measurement of the fibroblast growth factor 19 in a biological specimen." + }, + { + "input": "Concept: Right thoracic duct (Structure of right subclavian vein)", + "output": "something described as a lymphatic vessel that drains lymph from the right side of the head and neck, the right arm, and the right thoracic cavity." + }, + { + "input": "Concept: Approved Drug Product Manufactured Under Contract (Classification)", + "output": "Classification described as a marketing category specifying that an approved drug product is manufactured by a contract manufacturer and not marketed by the contract manufacturer." + }, + { + "input": "Concept: PEBP2aA (Gene or Genome)", + "output": "something described as human RUNX2 wild-type allele is located in the vicinity of 6p21 and is approximately 223 kb in length. This allele, which encodes runt-related transcription factor 2 protein, is involved in osteoblastic differentiation, skeletal morphogenesis and hematopoietic stem cell differentiation. Mutation of the gene is associated with cleidocranial dysplasia." + }, + { + "input": "Concept: regulation of xyloglucan metabolic process (regulation of cellular carbohydrate metabolic process)", + "output": "regulation of cellular carbohydrate metabolic process described as any process that modulates the frequency, rate or extent of xyloglucan metabolic process." + }, + { + "input": "Concept: Polymorphic Form Determination (quality assurance)", + "output": "Research Activity described as tests to determine the crystalline form of a particular solid material." + }, + { + "input": "Concept: PROPIKACIN (Organic Chemical)", + "output": "Organic Chemical described as an aminoglycoside antibiotic related to kanamycin B." + }, + { + "input": "Concept: TORCH Syndrome (Syndrome)", + "output": "Congenital neonatal infections described as an infection caused by bacteria, viruses or parasites transmitted directly from the mother to an embryo, fetus or neonate during pregnancy or childbirth. Clinical manifestations may include intrauterine growth restriction; a petechial rash, jaundice, hepatosplenomegaly; chorioretinitis, intracranial calcification and other abnormalities of the brain; and congenital heart defects." + }, + { + "input": "Concept: virotherapy (Biological Response Modifier Therapy)", + "output": "something described as treatment using an oncolytic virus (a virus that infects and breaks down cancer cells but not normal cells). Oncolytic virus therapy may make it easier to kill tumor cells with chemotherapy and radiation therapy. It is a type of targeted therapy." + }, + { + "input": "Concept: CHIVC1-CDC HIV Infection Category (CDC Classification System for HIV-Infected Adults and Adolescents Clinical Classification Question)", + "output": "something described as CDC Classification System for HIV-Infected Adults and Adolescents - CDC HIV infection category." + }, + { + "input": "Concept: Sponsor Study Reference Identifier (Intellectual Product)", + "output": "something described as the reference identifier that is assigned by the sponsor and by which the study is known to the sponsor." + }, + { + "input": "Concept: follicular lymphoma variant translocation 1 (Oxidoreductase Gene)", + "output": "Oxidoreductase Gene described as this gene plays a role in glycosphingolipid metabolism." + }, + { + "input": "Concept: amnio infusion (Obstetrics injection)", + "output": "something described as infusing a sterile solution into a client/patient's uterus during her labor to relieve umbilical cord compression and/or dilute meconium-stained fluid. Service is billed per procedure." + }, + { + "input": "Concept: Genito-urinary Cancer (Malignant Neoplasms)", + "output": "Neoplastic Process described as a primary or metastatic malignant neoplasm that affects the genitourinary system." + }, + { + "input": "Concept: integral component of phagophore assembly site membrane (Cell Component)", + "output": "integral to membrane described as the component of the phagophore assembly site membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." + }, + { + "input": "Concept: S. pneumonia Sero 23F IgG AB (Laboratory Procedure)", + "output": "Laboratory Procedure described as a measurement of the Streptococcus pneumoniae serotype 23F IgG antibody in a biological specimen." + }, + { + "input": "Concept: Moraxella atlantae (Bacterium)", + "output": "Bacterium described as any bacterial organism that can be assigned to the species Moraxella atlantae." + }, + { + "input": "Concept: Performed Study Subject Milestone (Performed Clinical Study Activity)", + "output": "Performed Clinical Study Activity described as the completed activity which marks a common administrative landmark for a study subject in the course of a study. EXAMPLE(S): obtain informed consent, verify eligibility criteria, enroll, registration to a study, randomize, assignment to a treatment arm, start of on-study period, complete study visits, end of on-study period, exit trial, break treatment blind, protocol violation, premature withdrawal." + }, + { + "input": "Concept: CSS0207 (C-SSRS Since Last Visit Questionnaire Question)", + "output": "Intellectual Product described as columbia-Suicide Severity Rating Scale Since Last Visit - How many times have you had these thoughts?" + }, + { + "input": "Concept: SPF (Radiometry)", + "output": "Spectrum Analysis described as a measure of relative protection provided by SUNSCREENING AGENTS against burns due to ultraviolet (UV) radiation from a light source." + }, + { + "input": "Concept: PSS-14 Questionnaire (Symptom Specific Assessment Tool)", + "output": "Symptom Specific Assessment Tool described as a 14 item self-report questionnaire that utilizes a 5-point Likert Scale rating system to assess an individual's perception of the stressfulness of life situations in the past month." + }, + { + "input": "Concept: Kalaallits (Population Group)", + "output": "Population Group described as an Inuit ethnic group geographically-associated with GREENLAND; (KALAALLIT NUNAAT)." + }, + { + "input": "Concept: H4 Protein (Biologically Active Substance)", + "output": "something described as coiled-coil domain-containing protein 6 (474 aa, ~53 kDa) is encoded by the human CCDC6 gene. This protein may be involved in tumor suppression." + }, + { + "input": "Concept: Thyroid Cancer Clinical TNM Finding v7 (Thyroid Cancer TNM Finding v7)", + "output": "Thyroid Cancer TNM Finding v7 described as a clinical finding about one or more characteristics of thyroid cancer, following the rules of the TNM AJCC v7 classification system. The assessment of a thyroid tumor depends on inspection and palpation of the thyroid gland and regional lymph nodes. Indirect laryngoscopy to evaluate vocal cord motion is essential. A variety of imaging procedures can provide additional useful information. These include radioisotope thyroid scans, ultrasonography, computed tomography scans (CT), magnetic resonance imaging (MRI) scans, and PET scans. The diagnosis of thyroid cancer must be confirmed by needle biopsy or open biopsy of the tumor." + }, + { + "input": "Concept: posterior parietal association areas (Body Location or Region)", + "output": "something described as the region between the visual cortex (rodent) and somatosensory areas; it receives inputs from the lateral posterior nucleus and may correspond to the posterior parietal association areas in primates and other mammals ( Swanson-2004 )." + }, + { + "input": "Concept: Grade 4 Vaccination complication (Finding)", + "output": "Finding described as life-threatening consequences; urgent intervention indicated" + }, + { + "input": "Concept: Office of Cancer Survivorship (Health Care Related Organization)", + "output": "Health Care Related Organization described as the Office of Cancer Survivorship was established in 1996 to provide support and a focus for research and other activities dealing with cancer survivors. OCS workshops were held in 1996 and 1997 to define priorities for research, which included the prevalence of physical effects from cancer treatment, the prevalence of second cancers in survivors, quality of life, and quality and cost of follow-up care for survivors." + }, + { + "input": "Concept: DRD2 wt Allele (Gene or Genome)", + "output": "DRD2 gene described as human DRD2 wild-type allele is located within 11q23 and is approximately 66 kb in length. This allele, which encodes D(2) dopamine receptor protein, plays a role in the inhibition of adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia and allelic variant mutants are associated with schizophrenia." + }, + { + "input": "Concept: HYDROXYPROLINEMIA (Disorder of proline AND/OR hydroxyproline metabolism)", + "output": "something described as an increased concentration of hydroxyproline in the blood." + }, + { + "input": "Concept: anatomic (Beginning)", + "output": "Anatomy Qualifier described as having to do with anatomy (the study of the structure of a plant or animal)." + }, + { + "input": "Concept: crowd (Spatial Behavior)", + "output": "Thesaurus of Psychological Index Terms described as an excessive number of individuals, human or animal, in relation to available space." + }, + { + "input": "Concept: dysmetabolic syndrome X (Endocrine system)", + "output": "cancer-related problem/condition described as a multifaceted syndrome characterized by clustering of insulin resistance and hyperinsulinemia, associated with dyslipidemia, essential hypertension, abdominal obesity, glucose intolerance or noninsulin dependent diabetes mellitus, and an increased risk of cardiovascular events." + }, + { + "input": "Concept: pteropterin (Folic Acid Antagonists)", + "output": "Folic Acid Antagonists described as a crystalline conjugate of folic acid, having general properties of a polypeptide. Pteropterin differs from folic acid in that it consists of three molecules of glutamic acid instead of one. Pteropterin can potentially be used as an antimetabolite in the treatment of cancer." + }, + { + "input": "Concept: Site of Fetal Membrane Rupture (Placental finding)", + "output": "something described as the distance between the shortest free edge of the fetal membranes and the disc edge." + }, + { + "input": "Concept: cilastatin (Medicinal product categorized by structure)", + "output": "Organic sulfide compound described as a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4." + }, + { + "input": "Concept: Cognitive discrimination (Thesaurus of Psychological Index Terms)", + "output": "Concept Formation described as differential response to different stimuli." + }, + { + "input": "Concept: Thoracic hypertrichosis (Hypertrichosis)", + "output": "Hypertrichosis described as excessive, increased hair growth located in the thoracic region." + }, + { + "input": "Concept: Anti-CD20 Monoclonal Antibody TL011 (Immunologic Factor)", + "output": "Anti-CD20 Monoclonal Antibody described as a monoclonal antibody directed against human CD20 with potential antineoplastic activity. Anti-CD20 monoclonal antibody TL011 specifically binds to the B cell-specific cell surface antigen CD20 antigen (MS4A1; membrane-spanning 4-domains, subfamily A, member 1), thereby potentially triggering an immune response against CD20-positive B cells, leading to B cell apoptosis. CD20 is a non-glycosylated cell surface phosphoprotein that is exclusively expressed on B cells during most stages of B cell development and is often overexpressed in B-cell malignancies. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C94206\" active clinical trials using this agent." + }, + { + "input": "Concept: bA449O16.3 (Gene or Genome)", + "output": "Gene or Genome described as human ASAH2B wild-type allele is located in the vicinity of 10q11.23 and is approximately 77 kb in length. This allele, which encodes putative inactive neutral ceramidase B protein, may be involved in ceramide metabolism." + }, + { + "input": "Concept: NPI1-Burden to Family (Intellectual Product)", + "output": "NPI Questionnaire Question described as neuropsychiatric Inventory - Does the patient say he/she is a burden to the family or that the family would be better off without him/her?" + }, + { + "input": "Concept: chlorobenzene metabolism (Molecular Function)", + "output": "something described as the chemical reactions and pathways involving chlorobenzene, a derivative of benzene with a chlorine atoms attached to the ring. It is a colorless liquid that is manufactured for use as a solvent. It quickly evaporates in the air and is degraded by hydroxyl radicals that are produced photochemically. The gas acts as a source of ClOx, which helps in the breakdown of stratospheric ozone." + }, + { + "input": "Concept: Cinarizina (antinauseants)", + "output": "Histamine H1 Antagonists described as a piperazine derivative having histamine H1-receptor and calcium-channel blocking activity with vasodilating and antiemetic properties but it induces PARKINSONIAN DISORDERS." + }, + { + "input": "Concept: absence; liver (Congenital Abnormality)", + "output": "something described as absence of the liver owing to a failure of the liver to develop." + }, + { + "input": "Concept: Sumetizide (Pharmacologic Substance)", + "output": "Thiazide Diuretics described as a sulfonamide derivative belonging to the class of the thiazide diuretics with anti-hypertensive activity. Sumetizide was never marketed." + }, + { + "input": "Concept: Monoclonal Mouse Anti-Human Melanosome, Clone HMB-45-Positive Cells Present (PMEL Positive)", + "output": "Laboratory or Test Result described as an immunohistochemical finding that the monoclonal antibody HMB-45 binds to a the cells in a biosample." + }, + { + "input": "Concept: Hyperlipoproteinaemia (Disorder of lipoprotein AND/OR lipid metabolism)", + "output": "Abnormality of lipoprotein cholesterol concentration described as metabolic disease characterized by excess plasma lipoproteins, due to a disorder of lipoprotein metabolism; may be acquired or familial." + }, + { + "input": "Concept: axonal peripheral neuropathy (Peripheral Nervous System Diseases)", + "output": "something described as an abnormality characterized by disruption of the normal functioning of peripheral axons." + }, + { + "input": "Concept: SEND Microscopic Findings Test Code (CDISC SEND Terminology)", + "output": "Intellectual Product described as the terminology that includes concepts relevant to the Clinical Data Interchange Standards Consortium (CDISC) Standard for the Exchange of Non-clinical Data (SEND) microscopic findings test short names." + }, + { + "input": "Concept: Areca / bing lang / da fu pi (Plant)", + "output": "Plant described as bing lang, da fu pi" + }, + { + "input": "Concept: Transition Point (Functional Concept)", + "output": "something described as the point at which something changes from one form to another." + }, + { + "input": "Concept: CAncer Rehabilitation Evaluation System for Research (Clinical or Research Assessment Questionnaire)", + "output": "Clinical or Research Assessment Questionnaire described as a self-reported, clinically relevant instrument designed to assess the rehabilitation needs and daily problems of patients with cancer." + }, + { + "input": "Concept: ATP-dependent organic acid transmembrane transporter activity (Molecular Function)", + "output": "organic acid transmembrane transporter activity described as enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + organic acid(out/in) = ADP + phosphate + organic acid(in/out)." + }, + { + "input": "Concept: Catheters, Vascular, Angioplasty, Atherectomy, Extirpative (Catheters, Vascular, Angioplasty, Atherectomy)", + "output": "something described as atherectomy angioplasty catheters that cut or shave atheroma and directly remove the excised material from the vessel using a collection chamber or suction port. These catheters typically consist either of a semiflexible catheter which includes a cup-shaped cutter that slices atheroma at the center of a nonflexible housing, and an opposing dilated balloon that forces the plaque through a window into the metal housing during each cut (directional atherectomy); or of a semiflexible, torque-controlled, hollow catheter that includes an introducer sheath over a central guide wire for proper alignment with the atherosclerotic lesion, a rotating cone-shaped cutter in a housing unit to shave the plaque, and a collecting vacuum bottle situated at the proximal end of the catheter (transluminal extraction catheters). Extirpative atherectomy catheters are mostly used for treating short, discrete, eccentrically placed atheroma, including calcific eccentric stenoses not normally amenable to balloon dilatation." + }, + { + "input": "Concept: FOXP4 gene (Transcription factor genes)", + "output": "Transcription factor genes described as this gene plays a role in the tissue-specific repression of gene transcription." + }, + { + "input": "Concept: 3'-phosphoadenylyl-sulfate:cortisol 21-sulfotransferase activity (sulfotransferase activity)", + "output": "sulfotransferase activity described as catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + cortisol = adenosine 3',5'-diphosphate + cortisol 21-sulfate + H(+)." + }, + { + "input": "Concept: Specify BRAF Exons Assessed (Intellectual Product)", + "output": "Intellectual Product described as a request to enter the BRAF exons assessed for mutations in this section of the form." + }, + { + "input": "Concept: Left testicular vein (Structure of left spermatic cord)", + "output": "Structure of testicular vein described as testicular vein, each instance of which is a tributary of some left renal vein that drains some left pampiniform plexus." + }, + { + "input": "Concept: Periodontitides (Inflammatory disorder of jaw region)", + "output": "something described as a disease that attacks the gum and bone around the teeth" + }, + { + "input": "Concept: Anti-CD20/CD3 Monoclonal Antibody REGN1979 (Antineoplastic Antibody)", + "output": "Amino Acid, Peptide, or Protein described as a bispecific, human monoclonal antibody with potential antineoplastic activity. Anti-CD20/CD3 monoclonal antibody REGN1979 contains two antigen-recognition sites: one for human CD3, a T cell surface antigen, and one for human CD20, a tumor-associated antigen that is exclusively expressed on B-cells during most stages of B-cell development and is often overexpressed in B-cell malignancies. Upon administration, REGN1979 binds to both T-cells and CD20-expressing tumor B-cells, which cross-links the T-cells to tumor cells, and may result in a potent cytotoxic T-lymphocyte (CTL) response against CD20-expressing tumor B-cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C119615\" active clinical trials using this agent." + }, + { + "input": "Concept: Archamoebae (Evosea)", + "output": "Evosea described as a group (some say infraphylum) of AMOEBOZOA that lack mitochondria." + }, + { + "input": "Concept: Ivory epiphysis of the terminal phalanx of the little finger (Ivory epiphyses of the distal phalanges of the hand)", + "output": "Ivory epiphyses of the 5th finger described as sclerosis of the epiphysis of the distal phalanx of the little finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays." + }, + { + "input": "Concept: Feeding Methods (Therapeutic procedure)", + "output": "Methods described as the technique for delivery of enteral nutrition." + }, + { + "input": "Concept: Resedaceae Martinov, 1820 (Rosanae)", + "output": "Plant described as a plant family of the order Capparales, subclass Dilleniidae, class Magnoliopsida. It is a small family of herbs and shrubs. Some produce GLUCOSINOLATES." + }, + { + "input": "Concept: negative regulation of type B pancreatic cell apoptotic process (negative regulation of epithelial cell apoptotic process)", + "output": "Cell Function described as any process that stops, prevents or reduces the frequency, rate or extent of type B pancreatic cell apoptotic process." + }, + { + "input": "Concept: epithelial cell migration involved in distal tubule morphogenesis (epithelial cell migration involved in nephron tubule morphogenesis)", + "output": "Cell Function described as the orderly movement of epithelial cells within a renal tubule that contributes to distal tubule morphogenesis." + }, + { + "input": "Concept: Surgical Anastomosis (Therapeutic or Preventive Procedure)", + "output": "Surgical Procedure by Type described as a natural or surgically-induced connection between tubular structures in the body." + }, + { + "input": "Concept: nitrilotriacetate monooxygenase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)", + "output": "Molecular Function described as catalysis of the reaction: nitrilotriacetate + O2 + FMNH2 = ammoniodiacetate + 2-oxo monocarboxylic acid anion + H2O + FMN." + }, + { + "input": "Concept: L-serine synthesis (serine family amino acid biosynthetic process)", + "output": "serine family amino acid biosynthetic process described as the chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." + }, + { + "input": "Concept: ovary right (Right side of trunk)", + "output": "Right uterine adnexa described as the ovary that is located in the right side of the pelvis." + }, + { + "input": "Concept: Product Expiration Date (Temporal Concept)", + "output": "Pharmaceutical Product Characteristics described as as part of the CGMP regulations, the FDA requires that drug products bear an expiration date determined by appropriate stability testing (21 CFR 211.137 and 211.166), after which the product may not meet the appropriate regulatory agencies requirements.. The FDA defines an expiration date as \"the date placed on the container/labels of a drug product designating the time during which a batch of the product is expected to remain within the approved shelf life specifications if stored under defined conditions, and after which it may not be used.\" Expiration dates are generally limited to no more than 3 years after production, but longer stability periods are allowed for some very stable materials." + }, + { + "input": "Concept: MIR382 Pre-miRNA (Nucleic Acid, Nucleoside, or Nucleotide)", + "output": "something described as MIR382 pre-microRNA (76 bases) is encoded by the human MIR382 gene. This oligoribonucleotide plays a role in the regulation of transcription." + }, + { + "input": "Concept: Retinoblastoma pT0 TNM Finding v8 (Finding)", + "output": "Finding described as no evidence of intraocular tumor." + }, + { + "input": "Concept: Breath stacking (Respiration Alteration)", + "output": "Finding described as condition where there are a greater number of inhalations relative to the number of exhalations." + }, + { + "input": "Concept: Fibroadenoma of Anogenital Mammary-Like Glands (Benign Reproductive System Neoplasm)", + "output": "Neoplasms, Fibroepithelial described as a benign epithelial-stromal neoplasm that arises from the perineum and resembles the breast fibroadenoma." + }, + { + "input": "Concept: bp monitors (Patient Monitoring)", + "output": "Self-Management: Dysrhythmia described as managing and/or monitoring a patient's blood pressure." + }, + { + "input": "Concept: type 2A serotonin receptor binding (G protein-coupled serotonin receptor binding)", + "output": "something described as interacting selectively and non-covalently with a type 2A serotonin receptor." + }, + { + "input": "Concept: Somewhat Difficult (Clinical or Research Assessment Answer)", + "output": "Clinical or Research Assessment Answer described as a subjective response indicating that an individual finds something to be somewhat difficult." + }, + { + "input": "Concept: vaginal tablets (Vaginal Dosage Form)", + "output": "Vaginal Dosage Form described as solid single-dose preparation consisting of a tablet, usually uncoated or film-coated, intended for administration to the vagina to obtain a local effect. Vaginal tablets are usually of larger size and a different shape from tablets intended for oral administration." + }, + { + "input": "Concept: Expanded Disability Rating Scale - Postacute Interview Survivor Version Questionnaire Test Code (CDISC Questionnaire Terminology)", + "output": "something described as test codes of questionnaire questions associated with the Expanded Disability Rating Scale - Postacute Interview Survivor Version (Expanded DRS-PI Survivor Version) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: Adult chronic idiopathic neutropenia (Acquired neutropenia)", + "output": "something described as a rare acquired immunodeficiency disease with characteristics of adult-onset absolute neutrophil counts less than 1.5 x 10^9/L on at least 3 occasions in a 3 month period that cannot be attributable to drugs or a specific genetic, infectious, inflammatory, autoimmune or malignant cause. Recurrent apthous stomatitis and a history of mild bacterial infections are typically associated. A benign outcome with a low rate of severe infections and no secondary malignancies is observed." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, GABRG2 (Medical Device)", + "output": "something described as molecular assay reagents intended to identify mutations in the gamma-aminobutyric acid type A receptor gamma2 subunit (GABRG2) gene, located at chromosome 5q34, which encodes the gamma-2 subunit of the gamma-aminobutyric acid receptor. Genetic variants at this locus have been associated with familial febrile seizures and childhood absence epilepsy." + }, + { + "input": "Concept: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity (Molecular Function)", + "output": "something described as catalysis of the reaction: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 = 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon." + }, + { + "input": "Concept: Pulsed Doppler Coronary Artery Catheters (Medical Device)", + "output": "Medical Device described as ultrasound vascular catheters designed to determine blood-flow velocity by measuring the ultrasound frequency shift between the transmitted and reflected signals (i.e., Doppler principle). These catheters typically consist of a 3 to 8 Fr tube with a ceramic crystal that is capable of transmitting and receiving ultrasound signals (20 MHz frequency is typical) and is attached at or near the distal tip. Two wires attached to the crystal are connected at the proximal end to a Doppler blood flowmeter. These catheters usually include an infusion lumen and/or an additional lumen for a guide wire. Doppler ultrasound catheters are used mainly to measure coronary hemodynamics (e.g., blood mean and peak velocity) during coronary catheterization." + }, + { + "input": "Concept: CRE (Response Elements)", + "output": "Gene or Genome described as a promoter sequence which interacts with CRE binding proteins to modulate gene expression in response to the level of cAMP in the cell." + }, + { + "input": "Concept: Mesothorium (Radioisotopes)", + "output": "something described as there are two mesothoriums produced in thorium decay. Mesothorium I is an isotope of radium; mesothorium II is an isotope of actinium." + }, + { + "input": "Concept: Amputation through metatarsal bones (Metatarsectomy)", + "output": "Metatarsectomy described as a surgical procedure in which all or part of the distal foot is removed distal to the tarsometatarsal joint(s)." + }, + { + "input": "Concept: Pregnancy;twins (Finding)", + "output": "MATERNAL AND FETAL CONDITIONS AFFECTING LABOR AND DELIVERY described as the condition of carrying TWINS simultaneously." + }, + { + "input": "Concept: countTypeDetailCode (Intellectual Product)", + "output": "something described as a coded value specifying a further description of the type of item being counted." + }, + { + "input": "Concept: SFOP-HM91 Regimen (Therapeutic or Preventive Procedure)", + "output": "something described as a regimen administered in four phases that is used for the treatment of disseminated, childhood, anaplastic large cell lymphoma (ALCL). The treatment plan consists of the following 4 phases: COP (cyclophosphamide, vincristine, and prednisone); COPADM (cyclophosphamide, vincristine, prednisone, doxorubicin and methotrexate); VEBBP (vinblastine, etoposide, bleomycin, prednisone); and Sequence 1 (vincristine, methotrexate, cyclophosphamide and doxorubicin)." + }, + { + "input": "Concept: cyst; bone, aneurysmal (Bone disorders NEC)", + "output": "something described as a locally aggressive and destructive benign cystic lesion of the bone. It is characterized by the formation of multiloculated hemorrhagic cystic spaces which are separated by fibrous septa. It can arise from any bone, but usually affects the metaphysis of long bones. It manifests with pain and swelling and may recur following curettage." + }, + { + "input": "Concept: formyl-methanofuran dehydrogenase (molybdenum enzyme) complex location (protein-containing complex)", + "output": "protein-containing complex described as a protein complex consisting of three polypeptides which also contains molybdenum, a molybdopterin guanine dinucleotide and iron-sulfur clusters. This protein complex catalyzes the reversible conversion of CO2 and methanofuran to formylmethanofuran during methanogenesis." + }, + { + "input": "Concept: Abnormal HDL3c concentration (Abnormal HDL subfraction concentration)", + "output": "Finding described as any deviation from the normal concentration of the HDL3c subfraction in the blood circulation. An HDL3c particle is defined as an HDL particle with a size of 7.20-7.79 nm." + }, + { + "input": "Concept: During the evening (Temporal periods of day)", + "output": "Night time described as the time period between late afternoon and bedtime." + }, + { + "input": "Concept: Institutional Review Board Independent Ethics Committee Approved Subject Diary (Document type)", + "output": "something described as an instrument approved by the Institutional Review Board (IRB)/Independent Ethics Committee (IEC) that is used to record subject data away from a clinical trial site." + }, + { + "input": "Concept: Adverse Event MedDRA Preferred Term Code (MedDRA Preferred Term Code)", + "output": "something described as a coded value specifying the preferred term for the adverse event from the Medical Dictionary for Regulatory Activities (MedDRA)." + }, + { + "input": "Concept: Vastus lateralis (Body part)", + "output": "something described as the largest muscle in the quadriceps femoris that is responsible for extending and stabilizing the knee." + }, + { + "input": "Concept: MPRAGE (Diagnostic Procedure)", + "output": "something described as a magnetic resonance imaging modality that offers rapid imaging time, easy reconstruction of any plane, and three-dimensional surface contour rendering with cut away postprocessing. Especially useful for imaging brain, MP-RAGE captures high tissue contrast and provides high spatial resolution with whole brain coverage in a short scan time." + }, + { + "input": "Concept: Polyketide (Pharmacologic Substance)", + "output": "Macrocyclic Compounds described as natural compounds containing alternating carbonyl and methylene groups (beta-polyketones), bioenergenetically derived from repeated condensation of acetyl coenzyme A via malonyl coenzyme A, in a process similar to fatty acid synthesis." + }, + { + "input": "Concept: SPRAY, METERED (Biomedical or Dental Material)", + "output": "something described as a non-pressurized dosage form consisting of valves which allow the dispensing of a specified quantity of spray upon each activation." + }, + { + "input": "Concept: Readiness for enhanced breastfeeding (Ingestion)", + "output": "something described as a pattern of feeding milk from the breasts to an infant or child, which may be strengthened." + }, + { + "input": "Concept: helminth genetics (Science of genetics)", + "output": "something described as heredity, especially the mechanisms of hereditary transmission and the variation of inherited characteristics among helminths; the genetic constitution of helminths, including the parasitic nematodes, platyhelminthes and acanthacephalides; also including the non-parasitic, free-living nematodes (C elegans), annelids (earthworms) and planarians." + }, + { + "input": "Concept: Grade 5 Death Related to Adverse Event (Finding)", + "output": "Adverse Event by CTCAE v3 Severity Grade described as the termination of life as a result of an adverse event." + }, + { + "input": "Concept: DonorRegistry.identifier (Intellectual Product)", + "output": "something described as a unique symbol that establishes identity of the donor registry. EXAMPLE(S): patient number 7 on a study OTHER NAME(S): NOTE(S):" + }, + { + "input": "Concept: Have you had pain or a burning feeling when urinating (Intellectual Product)", + "output": "something described as a question about the extent to which an individual has or had pain or a burning feeling when urinating." + }, + { + "input": "Concept: Biliary Liver Cirrhosis (Abnormal biliary tract morphology)", + "output": "Cirrhosis secondary to cholestasis described as progressive destruction of the small-to-medium bile ducts of the intrahepatic biliary tree, which leads to progressive cholestasis and often end-stage liver disease." + }, + { + "input": "Concept: BERGER DIS (Autoimmune Diseases)", + "output": "Kidney Diseases described as a chronic autoimmune glomerulonephritis characterized by the deposition of immunoglobulin A in the mesangium of the glomeruli. It is manifested with hematuria and mild proteinuria." + }, + { + "input": "Concept: Mouth Adenoid Cystic Carcinoma (Oral Cavity Carcinoma)", + "output": "cellular diagnosis, lip and oral cavity cancer described as an adenoid cystic carcinoma arising from the minor salivary glands in the oral cavity." + }, + { + "input": "Concept: Refractory Alveolar Rhabdomyosarcoma (Refractory Rhabdomyosarcoma)", + "output": "Alveolar rhabdomyosarcoma described as alveolar rhabdomyosarcoma that does not respond to treatment." + }, + { + "input": "Concept: GST Class-Alpha Member 1 (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as glutathione S-transferase A1 (222 aa, ~26 kDa) is encoded by the human GSTA1 gene. This protein is involved in glutathione metabolism." + }, + { + "input": "Concept: bmgntx ea.15min (Therapeutic or Preventive Procedure)", + "output": "something described as manipulating the magnetic field(s) of a client's body part, region or full body for therapeutic effect(s) (for example, to relieve pain). Service is billed in 15-minute increments." + }, + { + "input": "Concept: Restless Legs (Sensory abnormalities NEC)", + "output": "Sleep disturbances described as uncomfortable or painful sensation associated with an irresistible urge to move the limbs, usually triggered by relaxation or lying down." + }, + { + "input": "Concept: EXCISION REPAIR, COMPLEMENTING DEFECTIVE, IN CHINESE HAMSTER, 5 (Gene or Genome)", + "output": "DNA Repair Gene described as this gene plays a role in the nucleotide base excision repair of UV-induced DNA damage and mutations of the gene cause Cockayne syndrome." + }, + { + "input": "Concept: EXOI (Gene or Genome)", + "output": "EXO1 gene described as human EXO1 wild-type allele is located within 1q42-q43 and is approximately 42 kb in length. This allele, which encodes exonuclease 1 protein, plays a role in mismatch repair and recombination." + }, + { + "input": "Concept: honey drug (Pharmacologic Substance)", + "output": "Homeopathic remedies letter M described as honey." + }, + { + "input": "Concept: B0 ENDOCRINE SYSTEM: GENERAL TERMS (Anatomy)", + "output": "Croatian translation of the Medical Subject Headings described as collective designation for those tissues capable of secreting hormones." + }, + { + "input": "Concept: Other hered. haem. anaemias (Hemolytic disorder)", + "output": "Disease or Syndrome described as a congenital hemolytic anemia caused by defects of the erythrocyte membrane, enzyme deficiencies, or hemoglobinopathies." + }, + { + "input": "Concept: Procedure Kit/Trays, Blood Transfusion, Exchange (Medical Device)", + "output": "Medical Device described as prepackaged collections of the devices and supplies (i.e., either custom or standard kits) needed for repetitive removal of blood and replacement with transfused blood from a donor until most part of the patient's blood has been exchanged (i.e., exchange or exsanguination transfusion). Items in these kits usually include a stopcock extension tube, catheters (e.g., umbilical), syringes, and needles. The kits are frequently supplied in supporting trays (i.e., procedure trays) consisting of a flat-bottomed receptacle with a border around the periphery supporting all the instruments and supplies needed for the procedure; the trays are usually covered or wrapped. Exchange transfusion procedure kits and trays are mainly intended for counteracting the effects of serious jaundice (i.e., icterus) and/or other diseases in newborns; they are also used for other blood diseases such as sickle cell anemia. They are used in newborn, emergency, and intensive care areas in hospitals and other healthcare facilities." + }, + { + "input": "Concept: Left-sided (Spatial Concept)", + "output": "Spatial Concept described as being located on the left side of the body." + }, + { + "input": "Concept: fructose binding (monosaccharide binding)", + "output": "Molecular Function described as interacting selectively and non-covalently with the D- or L-enantiomer of fructose, the ketohexose arabino-hex-2-ulose." + }, + { + "input": "Concept: 3-Pyridylcarboxylic acid (Nicotinic Acid [EPC])", + "output": "Vitamin described as a water-soluble vitamin belonging to the vitamin B family, which occurs in many animal and plant tissues, with antihyperlipidemic activity. Niacin is converted to its active form niacinamide, which is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and its phosphate form, NADP. These coenzymes play an important role in tissue respiration and in glycogen, lipid, amino acid, protein, and purine metabolism. Although the exact mechanism of action by which niacin lowers cholesterol is not fully understood, it may act by inhibiting the synthesis of very low density lipoproteins (VLDL), inhibiting the release of free fatty acids from adipose tissue, increasing lipoprotein lipase activity, and reducing the hepatic synthesis of VLDL-C and LDL-C. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C689\" active clinical trials using this agent." + }, + { + "input": "Concept: CDISC Functional Test TMT Test Code Terminology (Intellectual Product)", + "output": "Intellectual Product described as trail Making Test test code." + }, + { + "input": "Concept: Health Facilities, Proprietary (Manufactured Object)", + "output": "something described as health care institutions operated by private groups or corporations for a profit." + }, + { + "input": "Concept: Ethenyl oxyethene (Ethers)", + "output": "General anesthetic drugs described as 1,1'oxybisethene; divinyl ether; C4H6O." + }, + { + "input": "Concept: downregulation of store-operated calcium channel activity (negative regulation of calcium ion transmembrane transporter activity)", + "output": "negative regulation of calcium ion transmembrane transporter activity described as any process that stops, prevents or reduces the frequency, rate or extent of store-operated calcium channel activity." + }, + { + "input": "Concept: Moraxella osloensis Bovre and Henriksen 1967 (Moraxella )", + "output": "Moraxella described as any bacterial organism that can be assigned to the species Moraxella osloensis." + }, + { + "input": "Concept: Radiologist 2 (radiologist)", + "output": "radiologist described as a radiologist performing the assessment that is given the designation of two." + }, + { + "input": "Concept: hapten (GENERAL ANTIGENS AND ANTIGENIC PHENOMENA)", + "output": "Epitopes described as small antigenic determinants capable of eliciting an immune response only when coupled to a carrier. Haptens bind to antibodies but by themselves cannot elicit an antibody response." + }, + { + "input": "Concept: HAQ02-Bend Down Pick Up Clothing - Floor (HAQ-DI Without VAS Questionnaire Question)", + "output": "something described as health Assessment Questionnaire Disability Index Without Pain Visual Analog Scale - Reach: Are you able to bend down to pick up clothing from the floor?" + }, + { + "input": "Concept: Tachycardia, SA Nodal Reentrant (Disease or Syndrome)", + "output": "Disease or Syndrome described as abnormally rapid heartbeats caused by reentry circuit in or around the SINOATRIAL NODE. It is characterized by sudden onset and offset episodes of tachycardia with a HEART RATE of 100-150 beats per minute. The P wave is identical to the sinus P wave but with a longer PR interval." + }, + { + "input": "Concept: C-SSRS Children's Baseline/Screening - First Suicide Attempt Actual Lethality/Medical Damage (Intellectual Product)", + "output": "something described as columbia-Suicidality Severity Rating Scale Children's Baseline/Screening (C-SSRS Children's Baseline/Screening) Initial/first attempt actual lethality/medical damage." + }, + { + "input": "Concept: Type IIb Sodium-Phosphate Symporter Proteins (Amino Acid, Peptide, or Protein)", + "output": "Biologically Active Substance described as a sodium-dependent phosphate transporter present primarily at apical sites of EPITHELIAL CELLS in the SMALL INTESTINE." + }, + { + "input": "Concept: nasopharyngeal carcinoma (Primary malignant neoplasm of nasopharynx)", + "output": "Primary malignant neoplasm of head described as cancer that forms in tissues of the nasopharynx (upper part of the throat behind the nose). Most nasopharyngeal cancers are squamous cell carcinomas (cancer that begins in flat cells lining the nasopharynx)." + }, + { + "input": "Concept: Prominent metopic suture (Abnormality of the metopic suture)", + "output": "Skull described as vertical bony ridge positioned in the midline of the forehead." + }, + { + "input": "Concept: Index Date (Date in time)", + "output": "Temporal Concept described as a date used as a reference point for ensuing events, often a diagnosis date, or a first visit date, or the date a patient enrolled in a study." + }, + { + "input": "Concept: Ocular Adnexal Lymphoma pM1a TNM Finding v7 (Finding)", + "output": "something described as noncontiguous involvement of tissues or organs external to the ocular adnexa (e.g., parotid gland, submandibular gland, lung, liver, spleen, kidney, breast, etc.)." + }, + { + "input": "Concept: sodium-dependent organic anion transport (organic anion transport)", + "output": "organic anion transport described as the directed, sodium-dependent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." + }, + { + "input": "Concept: Immune Costimulatory Protein B7 H4 (B7 Antigens)", + "output": "something described as a B7 antigen subtype that inhibits the costimulation of T-cell activation, proliferation, cytokine production and development of cytotoxicity. The over expression of this protein in a variety of tumor cell types suggests its role in TUMOR IMMUNE EVASION." + }, + { + "input": "Concept: subtraction hybridization (Molecular Biology Research Technique)", + "output": "something described as effectively subtracts the expressed mRNA complement from some baseline state or tissue from the expressed mRNA of the state or tissue of interest, leaving the fraction of mRNA which is uniquely expressed." + }, + { + "input": "Concept: Chemotherapeutic Hyperthermic Perfusion (Chemotherapeutic Perfusion)", + "output": "something described as a procedure in which a warmed solution containing anticancer drugs is used to bathe, or is passed through the blood vessels of, the tissue or organ containing the tumor." + }, + { + "input": "Concept: type III intermediate filament (Intermediate Filaments)", + "output": "Cell Component described as a type of intermediate filament that can form either homodimeric or heterodimeric complexes." + }, + { + "input": "Concept: lignoceroyl-CoA synthase activity (fatty acid ligase activity)", + "output": "Molecular Function described as catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22." + }, + { + "input": "Concept: posterior compartment specification (compartment pattern specification)", + "output": "something described as the process involved in the specification of cell identity in the posterior compartments of the segmented embryo." + }, + { + "input": "Concept: Signet Ring Cell Adenocarcinoma of Stomach (Gastric Poorly Cohesive Carcinoma)", + "output": "Gastric Poorly Cohesive Carcinoma described as a poorly cohesive gastric adenocarcinoma characterized by malignant cells containing intracytoplasmic mucin." + }, + { + "input": "Concept: INFECT TREPONEMAL (Disease or Syndrome)", + "output": "something described as infections with bacteria of the genus TREPONEMA." + }, + { + "input": "Concept: Corneal touch/IOL (General visual observation)", + "output": "Anatomical Abnormality described as complications of intraocular lens surgery; usually refers to intraocular lens contact with cornea, can be intermittent or chronic." + }, + { + "input": "Concept: Amplified musculoskeletal pain syndrome (Sensory abnormalities NEC)", + "output": "Syndrome described as a condition in which the nerves register normal stimuli (e.g., stimuli not causing tissue injury) as pain, resulting in feelings of intense pain with even minor sensory input." + }, + { + "input": "Concept: 1.3 (Study Data Tabulation Model Version)", + "output": "Intellectual Product described as the 1.3 version of the CDISC Study Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: BEBQ Retrospective Version - Baby Got Full Up Easily (Intellectual Product)", + "output": "Intellectual Product described as baby Eating Behaviour Questionnaire Retrospective Version (BEBQ Retrospective Version) My baby got full up easily." + }, + { + "input": "Concept: Intellectual disability, myopathy, short stature, endocrine defect syndrome (Autosomal recessive hereditary disorder)", + "output": "Disease or Syndrome described as a rare congenital myopathy syndrome characterised by nonprogressive myopathy (manifesting with mild facial and generalised weakness, bilateral ptosis, and severe lumbar lordosis), severe intellectual disability, short stature, and sexual infantilism (due to hypogonadotropic hypogonadism). The presence of a small pituitary fossa was also noted. There have been no further descriptions in the literature since 1985." + }, + { + "input": "Concept: Anniversary Events (Event Experiences)", + "output": "Event Experiences described as annual occurrence of a specific date that marks a notable event or experience. Includes aspects of both positive or negative reactions to the event or experience." + }, + { + "input": "Concept: central venous access catheter (Vascular infusion/aspiration catheter)", + "output": "something described as infusion catheters that are inserted and advanced to locate the distal tip in a central vein, typically the superior or inferior vena cava. These catheters may be inserted directly into a central vein, using surgical procedures, or percutaneously through the peripheral vasculature. Central venous infusion catheters are used when central venous pressure measurements are required, when larger volumes of solution must be rapidly administered, or to ensure rapid dilution and dispersion when high-viscosity fluids (e.g., packed cells), hyperosmolar fluids (e.g., hyperalimentation solutions), or certain drugs that are damaging to blood vessels (e.g., cytotoxins, highly acidic or alkaline drugs) must be infused." + }, + { + "input": "Concept: African Continental Ancestry Group (Population Group)", + "output": "Population Group described as individuals whose ancestral origins are in the continent of Africa." + }, + { + "input": "Concept: Nystagmus NOS (Sensory Function: Proprioception)", + "output": "Eye Movements described as rhythmic, involuntary oscillations of one or both eyes related to abnormality in fixation, conjugate gaze, or vestibular mechanisms." + }, + { + "input": "Concept: 10^6 Viral Particles (Quantitative Concept)", + "output": "something described as a unit for virus amount measurement that represents a number of viral particles (live and dead combined) expressed in millions." + }, + { + "input": "Concept: histone H3-T11 phosphorylation (histone-threonine phosphorylation)", + "output": "something described as the modification of histone H3 by the addition of an phosphate group to a threonine residue at position 11 of the histone." + }, + { + "input": "Concept: Familial essential thrombocythaemia (Hereditary Diseases)", + "output": "Hereditary Diseases described as a familial form of essential thrombocythemia, a myeloproliferative disorder characterized by a sustained elevation of platelet number with a tendency for thrombosis and hemorrhage. Patients commonly manifest microcirculatory disturbances or vaso-motor events. The disease is less frequently associated with an increased risk of hemorrhage, mild splenomegaly, and progression towards myelofibrosis with myeloid metaplasia or transformation to leukemia. The genetic cause of the inherited predisposition is not known. Transmission appears to be autosomal dominant with incomplete penetrance." + }, + { + "input": "Concept: BBC2 (BAD gene)", + "output": "Gene or Genome described as human BAD wild-type allele is located in the vicinity of 11q12.3 and is less than 1 kb in length. This allele, which encodes Bcl2-antagonist of cell death protein, is involved in the positive regulation of apoptosis." + }, + { + "input": "Concept: CRQ-SAS First Administration Version - Felt Discouraged or Down (Intellectual Product)", + "output": "something described as chronic Respiratory Questionnaire Self-Administered Standardized Format First Administration Version Questionnaire (CRQ-SAS First Administration Version) In general, how often during the last 2 weeks have you felt discouraged or down in the dumps?" + }, + { + "input": "Concept: 2 clinical phase trials (Clinical Study by Phase)", + "output": "something described as in Phase II clinical trials, the study drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety." + }, + { + "input": "Concept: olfactogenital dysplasia (Olfactory Nerve Disorder)", + "output": "MULTISYSTEM DISORDER described as anosmia due to failure of the olfactory lobes to develop, with secondary hypogonadism due to gonadotropic hormone deficiency." + }, + { + "input": "Concept: Cant of occlusal plane down on right due to dental asymmetry (Finding)", + "output": "Dental occlusion finding described as a measure of the slope of the occlusal plane on the right to the Frankfort horizontal in degrees, related to tooth eruption." + }, + { + "input": "Concept: web browser (Intellectual Product)", + "output": "Computer software described as a computer program that interprets HTML and other Internet languages and protocols and displays web pages on a computer monitor." + }, + { + "input": "Concept: GAST-17 (Pharmacologic Substance)", + "output": "something described as a C-terminal amidated synthetic gastrin analog with a single amino acid change at position 15, where leucine replaces methionine, with potential hypoglycemic and immunomodulatory activities. Following pancreatic islet cell transplantation, subcutaneous administration of [Leu15] Gastrin-17 (GAST-17) may induce pancreatic beta cell regeneration and expansion and enhance the insulin secretory capacity of islet cell grafts. Additionally, GAST-17 may reduce inflammation within the islet cell environment, which could potentially improve islet graft survival and function. Gastrin, a gastrointestinal peptide, may induce beta cell neogenesis via induction of the duodenal and pancreatic homeobox transcription factor, PDX-1. Gastrin may also promote beta cell proliferation and neogenesis indirectly through increasing the production of clustrin, a beta cell expansion factor." + }, + { + "input": "Concept: CDISC SDTM Discharge Disposition Terminology (Intellectual Product)", + "output": "something described as the destination or circumstance at the time of discharge." + }, + { + "input": "Concept: Increased circulating procalcitonin level (Abnormal calcium-phosphate regulating hormone level)", + "output": "Finding described as an elevated concentration of procalcitonin in the blood circulation." + }, + { + "input": "Concept: p450 2d6 (Amino Acid, Peptide, or Protein)", + "output": "Cytochrome P450 described as a cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population." + }, + { + "input": "Concept: C-SSRS Since Last Visit - Description of Suicidal Ideation-No Intent (Intellectual Product)", + "output": "C-SSRS Since Last Visit Questionnaire Question described as columbia-Suicide Severity Rating Scale Since Last Visit - Description of active suicidal ideation with any methods (not plan) without intent to act." + }, + { + "input": "Concept: /nL (Quantitative Concept)", + "output": "Unit of Number Concentration described as a derived unit expressed as a number or quantity of objects in billions per unit of volume equal to one liter, or the equivalent in milliliters or microliters." + }, + { + "input": "Concept: sarcomeric muscle contraction (Muscle Contraction)", + "output": "Organ or Tissue Function described as a process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope." + }, + { + "input": "Concept: KATP-Associated Hyperinsulinism (Disorder of endocrine pancreas)", + "output": "Disorder of endocrine pancreas described as hyperinsulinism caused by non-functional beta-cell ATP-sensitive potassium channels due to inactivating mutation(s) in either the ABCC8 or KCNJ11 gene." + }, + { + "input": "Concept: spermatoproteasome complex (Cell Component)", + "output": "something described as a proteasome specifically found in mammalian testis. Contains the proteasome activator PA200 in the regulatory particle, and beta1i, beta2i, beta5i and/or alpha4s in the core (20S) subunit. Beta1i, beta2i and beta5i are inducible catalytic subunits, closely related to beta1, beta2 and beta5. Alpha4s is a sperm-specific 20S subunit, but unlike other alternative 20S subunits alpha4s lies in the outer alpha-ring and lacks catalytic activity." + }, + { + "input": "Concept: Electrocardiogram U wave present (EKG wave, interval AND/OR segment)", + "output": "something described as an electrocardiographic finding of a small hump following the T wave occurring during the final phase of Purkinje repolarization." + }, + { + "input": "Concept: Judgement, Clinical (Mental Process)", + "output": "Mental Process described as process by which clinicians collect signs and process information to understand the patient's medical situation or problem, and then plan and implement appropriate medical interventions." + }, + { + "input": "Concept: Bottle (Potency Unit)", + "output": "Unit dose described as a dosing unit equal to the amount of active ingredient(s) contained in a bottle." + }, + { + "input": "Concept: Fasting pattern in one calendar month, reported (Temporal Concept)", + "output": "something described as the timing within one calendar month when the client does not take in or infuse nutrients (e.g., every Sabbath)." + }, + { + "input": "Concept: Infection, Gnathostoma (Disease or Syndrome)", + "output": "Disease or Syndrome described as an infection that is caused by nematodes of the genus Gnathostoma, which is commonly found in Southeast Asia, and which is transmitted via the consumption of contaminated raw/undercooked birds, eels, fish, frogs, or reptiles. The pattern of symptoms is species-dependent, and extraintestinal manifestations are due to larval migration (e.g., pulmonary infiltrates, eosinophilic meningitis, or painful, pruritic subcutaneous swellings, and peripheral blood eosinophilia)." + }, + { + "input": "Concept: Cavity of tunica vaginalis (Body Space or Junction)", + "output": "Structure of cavity of serous sac described as cavity of serous sac surrounded by the tunica vaginalis." + }, + { + "input": "Concept: AVL01105 (Intellectual Product)", + "output": "ADNI-AVLT Questionnaire Question described as alzheimer's Disease Neuroimaging Initiative Auditory Verbal Learning Test Version A (ADNI-AVLT Version A) List B, Word 3." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Clinical Chemistry, Protein, Albumin, Microalbuminaria (IVD Test Reagent/Kits, Clinical Chemistry, Protein, Albumin)", + "output": "IVD Test Reagent/Kits, Clinical Chemistry, Protein, Albumin described as clinical chemistry reagents intended to perform semiquantitative chemical analysis of body fluids (typically urine) to determine albumin levels greater than normal, but less that the levels than can be detected in routine screening tests. Urinary albumin excretion is a marker of microvascular disease, and it precedes and is highly predictive of diabetic nephropathy and end-stage renal disease." + }, + { + "input": "Concept: deficiency; thiamine (Other nutritional deficiency)", + "output": "Water soluble vitamin deficiencies described as nutritional condition produced by a deficiency of thiamine in the diet, characterized by anorexia, irritability, and weight loss; later, patients experience weakness, peripheral neuropathy, headache, and tachycardia; in addition to being caused by a poor diet, thiamine deficiency in the United States most commonly occurs as a result of alcoholism, since ethanol interferes with thiamine absorption." + }, + { + "input": "Concept: Skin pit (Anatomical Abnormality)", + "output": "Anatomical Abnormality described as a small, skin-lined tract that leads from the surface to deep within the tissues. []" + }, + { + "input": "Concept: Grade 1 Erectile Dysfunction, CTCAE (Erectile Dysfunction, CTCAE)", + "output": "Finding described as decrease in erectile function (frequency or rigidity of erections) but intervention not indicated" + }, + { + "input": "Concept: neem tree (Plant)", + "output": "Meliaceae described as a plant genus of the family MELIACEAE. Members contain azadirachtin A (a limonoid commonly referred to as azadirachtin) and other TRITERPENES. They have been used in PESTICIDES. The old name of Melia azadirachta is very similar to a related plant, MELIA AZEDARACH." + }, + { + "input": "Concept: cellular response to wartmannin (cellular response to organic cyclic compound)", + "output": "Cell Function described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a wortmannin stimulus." + }, + { + "input": "Concept: effluvium; telogen (Hair and hair follicle diseases)", + "output": "something described as a type of hair loss characterized by an abnormal increase in dormant, telogen stage hair follicles. []" + }, + { + "input": "Concept: Century History, 15th (Temporal Concept)", + "output": "Temporal Concept described as time period from 1401 through 1500 of the common era." + }, + { + "input": "Concept: Performed Observation Focal Duration (Temporal Concept)", + "output": "Temporal Concept described as the quantity of time in which the observation result is held to be true. EXAMPLE(S): 2 months is the focalDuration for a question such as \"Have you smoked in the last 2 months?\". NOTE(S): The focalDuration can be derived using the focalDateRange." + }, + { + "input": "Concept: 9p13-p12 (Cell Component)", + "output": "Cell Component described as a chromosome band present on 9p" + }, + { + "input": "Concept: Cytoplasmic Granules (Cytoplasmic Vesicles)", + "output": "something described as insoluble nonmembranous particles found in cytoplasm." + }, + { + "input": "Concept: polycythemia vera (Myeloproliferative disease)", + "output": "Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes described as a chronic myeloproliferative neoplasm characterized by an increased red blood cell production. The bone marrow is hypercellular due to a panmyelotic proliferation typically characterized by pleomorphic megakaryocytes. The major symptoms are related to hypertension, splenomegaly or to episodes of thrombosis and/or hemorrhage." + }, + { + "input": "Concept: stage IIIC colon cancer (Stage III Colon Cancer AJCC v8)", + "output": "Stage III Colon Cancer described as stage IIIC includes: (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0). T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor invades through the visceral peritoneum (including gross perforation of the bowel through tumor and continuous invasion of tumor through areas of inflammation to the surface of the visceral peritoneum). T4b: Tumor directly invades or adheres to adjacent organs or structures. N1: One to three regional lymph nodes are positive (tumor in lymph nodes measuring 0.2 mm or more), or any number of tumor deposits are present and all identifiable lymph nodes are negative. N2: Four or more regional lymph nodes are positive. N2a: Four to six regional lymph nodes are positive. N2b: Seven or more regional lymph nodes are positive. M0: No distant metastasis." + }, + { + "input": "Concept: SERV HEALTH (Health Care Activity)", + "output": "Therapeutic procedure described as services and programmes at a local, community, regional, state or national level, aimed at delivering interventions to individuals for their physical, psychological and social well-being, such as health promotion and disease prevention services, primary care services, acute care, rehabilitation and long-term care services; services that are publicly or privately funded, delivered on a short-term, long-term, periodic or one-time basis, in a variety of service settings such as community, home-based, school and work settings, general hospitals, speciality hospitals, clinics, and residential and non-residential care facilities, including those who provide these services." + }, + { + "input": "Concept: PODCI Adolescent Parent-Reported Version (Clinical or Research Assessment Questionnaire)", + "output": "Clinical or Research Assessment Questionnaire described as pediatric Outcomes Data Collection Instrument (PODCI), Adolescent Parent-Reported (Daltroy LH, Liang MH, Fossel AH, Goldberg MJ, and The Outcomes Instrument Development Work Group. The POSNA Pediatric Musculoskeletal Functional Health Questionnaire:report on reliability, validity, and sensitivity to change. J Pediatr Orthop 1998; 18: 561-71)." + }, + { + "input": "Concept: bathed (Action)", + "output": "something described as the immersion or washing of the body or any of its parts in water or other medium for cleansing or medical treatment. It includes bathing for personal hygiene as well as for medical purposes with the addition of therapeutic agents, such as alkalines, antiseptics, oil, etc." + }, + { + "input": "Concept: BoNT/B2 (Pharmacologic Substance)", + "output": "Amino Acid, Peptide, or Protein described as the biotoxin botulinum neurotoxin B2." + }, + { + "input": "Concept: Arcus of cornea (Corneal Opacity)", + "output": "Corneal Diseases described as a hazy, grayish-white ring about 2 mm in width located close to but separated from the limbus (the corneoscleral junction). Corneal arcus generally occurs bilaterally, and is related to lipid deposition in the cornea. Corneal arcus can occur in elderly persons as a part of the aging process but may be associated with hypercholesterolemia in people under the age of 50 years." + }, + { + "input": "Concept: Poisoning by (Poisoning and toxicity)", + "output": "injuries or accidents described as condition or physical state produced by the ingestion, injection or inhalation of, or exposure to a deleterious agent." + }, + { + "input": "Concept: Replication Protein A 32 kDa Subunit (DNA-Binding Proteins)", + "output": "DNA-Binding Proteins described as CST complex subunit STN1 (368 aa, ~42 kDa) is encoded by the human STN1 gene. This protein is involved in DNA binding, telomere homeostasis and DNA replication." + }, + { + "input": "Concept: Chronic course - prolonged duration (Temporal pattern)", + "output": "Temporal Concept described as a disease or condition that persists or progresses over a long period of time." + }, + { + "input": "Concept: redxn labr pn ice msg ea.20m (Therapeutic or Preventive Procedure)", + "output": "something described as applying ice and/or acupressure to a client/patient's meridian points to reduce her labor pain. Service is billed in 20-minute increments." + }, + { + "input": "Concept: DCEP Plus Velcade (Regimen Used to Treat Plasma Cell Myeloma)", + "output": "something described as a chemotherapy regimen consisting of bortezomib, dexamethasone, cyclophosphamide, etoposide, and cisplatin that can be used in the treatment of plasma cell (multiple) myeloma." + }, + { + "input": "Concept: Flesh of muscle (Organ component)", + "output": "something described as organ component which has as its parts the entirety of muscle fasciculi." + }, + { + "input": "Concept: crisnatol mesylate (Pharmacologic Substance)", + "output": "something described as an anticancer drug that interferes with the DNA in cancer cells." + }, + { + "input": "Concept: regulation of receptor-mediated endocytosis involved in cholesterol transport (regulation of intracellular cholesterol transport)", + "output": "something described as any process that modulates the frequency, rate or extent of receptor-mediated endocytosis involved in cholesterol transport." + }, + { + "input": "Concept: Placental enlargement (Finding)", + "output": "Abnormal placental size described as increased size of the placenta." + }, + { + "input": "Concept: Equipoise, Therapeutic (Research Activity)", + "output": "something described as expectation of real uncertainty on the part of the investigator regarding the comparative therapeutic merits of each arm in a trial." + }, + { + "input": "Concept: Selig-Benacerraf-Greene syndrome (Renal dysplasia)", + "output": "something described as characterised by bilateral renal agenesis or dysplasia, megacystis secondary to urethral obstruction and sirenomelia. The disorder is lethal." + }, + { + "input": "Concept: MDS-UPDRS - Pronanation-Supination Movement of Right Hand (MDS-UPDRS Questionnaire Question)", + "output": "Intellectual Product described as the Movement Disorder Society version of the Unified Parkinson's Disease Rating Scale - Pronation-Supination Movements of Right Hand." + }, + { + "input": "Concept: T Wave Duration, Aggregate (Quantitative Concept)", + "output": "Quantitative Concept described as an aggregate T wave duration value based on the measurement of T wave duration intervals from multiple beats within a single ECG. The method of aggregation, which can vary, is typically a measure of central tendency such as the mean." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Immunoassay, Protein, Alpha-1-Microglobulin (IVD Test Reagent/Kits, Immunoassay, Protein)", + "output": "IVD Test Reagent/Kits, Immunoassay, Protein described as immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., plasma, serum, urine, amniotic fluid) to determine the protein alpha-1-microglobulin (A1MG), a low-molecular-weight protein. Increased ratios of alpha-1-microglobulin/creatinine in urine are associated with kidney tubule and/or glomerular damage, especially in children. High levels of placental A1MG in the serum of pregnant woman may be considered an indicator of intrauterine diseases (e.g., intrauterine hypoxia)." + }, + { + "input": "Concept: Double outlet right ventricle with non-committed ventricular septal defect and pulmonary stenosis (Congenital Abnormality)", + "output": "Double Outlet Right Ventricle described as a double outlet right ventricle with a non-committed ventricular septal defect (VSD), which is a VSD that is anatomically related to, or close to, neither great vessel, being separated from both by considerable muscle, and also has a pulmonary stenosis; abnormal narrowing or constriction of the pulmonary artery, in the main pulmonary artery and/or in the left or right pulmonary artery branches." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Infection, Fungi/Yeast, Coccidioides immitis (IVD Test Reagent/Kits, Molecular Assay, Infection, Fungi/Yeast)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Infection, Fungi/Yeast described as molecular assay reagents intended to identify Coccidioides immitis, a species of imperfect fungi of the family Moniliaceae, by detecting specific nucleic-acid information (e.g., DNA, RNA) of the target microorganism. These fungi may cause coccidiomycosis, a mycotic infection of the respiratory tract characterized by allergic manifestations; it may progress to a virulent, severe, chronic granulomatous disease involving tissue, viscera, and the central nervous system in immunocompromised patients." + }, + { + "input": "Concept: Computer-Aided Design/Manufacturing Systems, Orthopedic, Foot Orthosis/Prosthesis (Manufactured Object)", + "output": "Computer-Aided Design/Manufacturing Systems, Orthopedic described as systems designed for manufacturing and/or repair of foot orthopedic orthoses and prostheses using computer-assisted design and manufacturing (CAD/CAM) techniques. These systems typically consist of a scanning unit that combines light sources and a video camera for in-vivo scanning of the foot, a workstation with appropriate software to process the data from the digital topographical image taken by the scanner and provide output for a computerized manufacturing unit (e.g. milling/drilling or additive manufacturing machine), and an automated computer milling/drilling machine that manufacture the orthosis and/or prosthesis. Some systems may also take digitized data from mechanical contact mapping units (e.g., foot plantar shape and/or pressure digitizer). CAD/CAM foot orthopedic systems are intended for automated manufacturing of orthoses and prostheses from ceramic, composite plastics, and/or metal blocks. All units of the systems may be located in orthopedic offices or the manufacturing unit may be located in a separate orthopedic laboratory." + }, + { + "input": "Concept: Device-device incompatibility (Device incompatibility issues)", + "output": "Phenomenon or Process described as problem associated with the incompatibility of two or more devices while being operated in the same use environment thereby leading to a dysfunction of more than one device." + }, + { + "input": "Concept: MIR29B1 Pre-miRNA (Nucleic Acid, Nucleoside, or Nucleotide)", + "output": "Nucleic Acid, Nucleoside, or Nucleotide described as MIR29B1 pre-miRNA is an oligonucleotide that is encoded by the human MIR29B1 gene and has a role in the regulation of gene expression." + }, + { + "input": "Concept: Synovial tendon sheath of extensor digitorum and extensor indicis (Wrist)", + "output": "Wrist described as synovial tendon sheath of hand, each instance of which surrounds the tendon of some extensor digitorum and extensor indicis muscles, passing into some hand on the posterior side of some wrist." + }, + { + "input": "Concept: Grade 4 Skin Ulceration, CTCAE (Finding)", + "output": "Skin Ulceration, CTCAE described as any size ulcer with extensive destruction, tissue necrosis, or damage to muscle, bone, or supporting structures with or without full thickness skin loss" + }, + { + "input": "Concept: T cell activation involved in immune response (T-Cell Activation)", + "output": "lymphocyte activation involved in immune response described as the change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." + }, + { + "input": "Concept: Miescher syndrome 2 (DISEASES OF THE ENDOCRINE PANCREAS INCLUDING DIABETES)", + "output": "ENDOCRINE FEATURES described as congenital disorders, usually autosomal recessive, characterized by severe generalized lack of ADIPOSE TISSUE, extreme INSULIN RESISTANCE, and HYPERTRIGLYCERIDEMIA." + }, + { + "input": "Concept: Neonatal rickets (Neonatal metabolic disorder)", + "output": "Rickets described as a condition characterized by decreased mineral content of the bone of a fetus or infant due to inadequate availability of calcium and/or phosphorus. Associated risk factors include the degree of prematurity, low birth weight, medication exposures, immobilization, and nutrient insufficiency. Metabolic bone disease of prematurity is characterized by hypophosphatemia, hyperphosphatasia, and secondary hyperparathyroidism, and may include rachitic bony changes and fractures. Inadequate bone mineralization may contribute to bronchopulmonary dysplasia and poor growth." + }, + { + "input": "Concept: Hypersomnia, CTCAE (Nervous System Disorders, CTCAE)", + "output": "Nervous System Disorders, CTCAE described as a disorder characterized by characterized by excessive sleepiness during the daytime." + }, + { + "input": "Concept: Osteolytic defects of the proximal phalanges of the toes (Osteolytic defects of the phalanges of the toes)", + "output": "Osteolytic defects of the phalanges of the toes described as dissolution or degeneration of bone tissue of the proximal toe phalanx." + }, + { + "input": "Concept: anti-GPC3 monoclonal antibody GC33 (Immunologic Factor)", + "output": "something described as a humanized monoclonal antibody directed against the cell surface oncofetal protein glypican-3 (GPC3) with potential antineoplastic activity. Anti-GPC3 monoclonal antibody GC33 binds to GPC3 and triggers a host immune response against GPC3-expressing tumor cells, which may result in tumor cell death. GPC3, a heparin sulfate proteoglycan, is frequently upregulated in hepatocellular carcinoma and mesoderm-derived organs such as the liver, lungs, and kidney. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C80043\" active clinical trials using this agent." + }, + { + "input": "Concept: Basal Plate (Embryonic Structure)", + "output": "Embryonic Structure described as an embryologic structure that develops as a result of the proliferation of ectodermal cells in the mantle layer of the portion the neural tube that is developing into the spinal cord. Each of the basal plates is a relatively large anterior thickening of the mantle layer of neural tube that becomes an anterior gray column of the spinal cord ( Carpenter-1983 )." + }, + { + "input": "Concept: DRRI-2 - A: Unwanted Sex Activity Adulthood (DRRI-2 Questionnaire Question)", + "output": "something described as deployment Risk and Resilience Inventory-2 (DRRI-2) Before deployment: I experienced unwanted sexual activity as a result of force, threat of harm, or manipulation during adulthood (age 18 or later)." + }, + { + "input": "Concept: closures suture (Introduction procedure)", + "output": "Introduction procedure described as approximating edges of a wound using sterile suture material and a needle" + }, + { + "input": "Concept: Grade 2 Wound Complication, CTCAE (Wound Complication, CTCAE)", + "output": "Finding described as bedside local care indicated" + }, + { + "input": "Concept: Monocyte Chemotactic Protein 3 (Monocyte Chemoattractant Proteins)", + "output": "something described as a monocyte chemoattractant protein that has activity towards a broad variety of immune cell types. Chemokine CCL7 has specificity for CCR1 RECEPTORS; CCR2 RECEPTORS; and CCR5 RECEPTORS." + }, + { + "input": "Concept: KIAA1549/BRAF Fusion Gene (Genes, Regulator)", + "output": "Gene or Genome described as a fusion gene that results from a tandem duplication of approximately 2 Mb at 7q34 which fuses exon 15 or 16 of the KIAA1549 gene to exon 9 or 11 of the BRAF gene. This fusion is associated with pilocytic astrocytoma." + }, + { + "input": "Concept: GATA1 wt Allele (GATA1 gene)", + "output": "GATA1 gene described as human GATA1 wild-type allele is located in the vicinity of Xp11.23 and is approximately 8 kb in length. This allele, which encodes erythroid transcription factor protein, is involved in the regulation of both transcription by RNA polymerase II and erythroid development." + }, + { + "input": "Concept: Abnormality of corneal stroma (Anatomical Abnormality)", + "output": "Abnormal cornea morphology described as an abnormality of the stroma of cornea, also known as the substantia propria of cornea." + }, + { + "input": "Concept: Metavir Fibrosis Score (Disease Grade Qualifier)", + "output": "Disease Grade Qualifier described as a scoring system for liver fibrosis developed by Bedossa and Poynard (Bedossa P, Poynard T. An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. Hepatology. 1996 Aug; 24(2):289-93.), based on a 5 category scale." + }, + { + "input": "Concept: Recorders, Physiologic, Physical Activity/Sleep/Awake (Medical Device)", + "output": "Medical Device described as electronic storage data recorders designed to measure and record physical activity (i.e., body movements) and physiologic parameters. These recorders are usually devices intended to be worn by the user. They include sensors to measure physiologic parameters (e.g., skin temperature, pulse rate) as well as external acceleration sensors that are typically attached to a patient's wrist or to the ankle to measure user's movement (i.e., activity). Physical activity/physiologic recorders also include electronic circuits that can process the data using dedicated software, and an electronic memory to store the information. The stored information is intended for later computer analysis; some recorders allow the programming of the sample period (e.g., time on, time off, number of recording days). These devices are used to assess the physical status of users in daily life activities, frequently during rehabilitation." + }, + { + "input": "Concept: response to interleukin-6 (response to cytokine)", + "output": "response to cytokine described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus." + }, + { + "input": "Concept: up-regulation of G1 to G0 transition (Cell Function)", + "output": "regulation of G1 to G0 transition described as any process that activates or increases the frequency, rate or extent of G1 to G0 transition." + }, + { + "input": "Concept: Tacks, Sacculotomy (Medical Device)", + "output": "something described as a sacculotomy tack (Cody tack) is a device that consists of a pointed stainless steel tack intended to be implanted to relieve the symptoms of vertigo. The device repetitively ruptures the utricular membrane as the membrane expands under increased endolymphatic pressure." + }, + { + "input": "Concept: sedge family (Magnoliopsida)", + "output": "Plant described as the sedge plant family of the order Cyperales, subclass Commelinidae, class Liliopsida" + }, + { + "input": "Concept: uterine wall breakdown (Organ or Tissue Function)", + "output": "Organ or Tissue Function described as the sloughing of the endometrium and blood vessels during menstruation that results from a drop in progesterone levels." + }, + { + "input": "Concept: TAFII80 (Transcription Factors, General)", + "output": "something described as transcription initiation factor TFIID subunit 6 (677 aa, ~72 kDa) is encoded by the human TAF6 gene. This protein is involved in the regulation of transcription by RNA polymerase II." + }, + { + "input": "Concept: Software, Luminometer, Adenosine Triphosphate Organic Contamination (Computer software)", + "output": "Computer software described as luminometer software designed to process data obtained while measuring adenosine triphosphate (ATP) to evaluate organic contamination using a standard computer. This software is intended to evaluate the results of measurements performed with the luminometer; they work only with one or a few models of ATP luminometers, usually from the same manufacturer. The software may perform a variety of algorithms to provide customized reports, differentiate re-testing data, and provide data archive capabilities that enable analysis of historical records; the software may also establish limits for pass/fail interpretation. ATP organic contamination software is usually not available separate from the luminometer but may be updated (i.e., through the release of modified versions) during the life of the equipment." + }, + { + "input": "Concept: ODI01-Lifting (ODI v2.1a Questionnaire Question)", + "output": "something described as the Oswestry Disability Index Version 2.1a - Section 3 - Lifting." + }, + { + "input": "Concept: Filgrastim-containing product (Recombinant human granulocyte colony stimulating factor)", + "output": "Pharmacologic Substance described as a recombinant, non-glycosylated cytokine which is chemically identical to or similar to the endogenous cytokine human granulocyte colony-stimulating factor (G-CSF) isoform B, with immunomodulating activity. Filgrastim binds to and activates G-CSF receptors with the same biological activity and stability as the endogenous cytokine, thereby controlling the production, differentiation, and function of neutrophilic granulocyte progenitors. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1474\" active clinical trials using this agent." + }, + { + "input": "Concept: FIBRINOGEN AND SPLIT PRODUCTS, RHODAMINE, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)", + "output": "Indicator, Reagent, or Diagnostic Aid described as a fibrinogen determination system is a device that consists of the instruments, reagents, standards, and controls used to determine the fibrinogen levels in disseminated intravascular coagulation (nonlocalized clotting within the blood vessels) and primary fibrinolysis (the dissolution of fibrin in a blood clot)." + }, + { + "input": "Concept: Basal Cell Carcinoma of the Prostate (Neoplastic Process)", + "output": "Basal cell carcinoma described as an invasive prostate carcinoma composed of prostatic basal cells." + }, + { + "input": "Concept: I have no saliva (Intellectual Product)", + "output": "something described as a response indicating that an individual has no saliva." + }, + { + "input": "Concept: Grade I (Finding)", + "output": "Finding described as a heart sound that is very soft or intermittently heard." + }, + { + "input": "Concept: solubility (Physical Phenomenon or Property)", + "output": "solution described as quality or fact of being soluble; susceptibility of being dissolved." + }, + { + "input": "Concept: Galvanic skin response, function (Response process)", + "output": "something described as a change in electrical resistance of the skin, occurring in emotion and in certain other conditions." + }, + { + "input": "Concept: HIP PROSTHESIS (Prosthesis)", + "output": "Lower limb joint prosthesis described as replacement for a hip joint." + }, + { + "input": "Concept: IVD Panels, Human Genetics, Metabolic Disorder, Peroxisomal Disorder, Zellweger Spectrum, Comprehensive, Mutation (IVD Panels, Human Genetics, Metabolic Disorder, Peroxisomal Disorder, Zellweger Spectrum)", + "output": "Medical Device described as molecular assay reagents intended to identify mutations in the majority of genes known to be associated with Zellweger spectrum, a collection of peroxisomal disorders (including infantile Refsum disease, neonatal adrenoleukodystrophy, and Zellweger syndrome) that effect many parts of the body. Genetic variants at multiple loci have been associated with Zellweger spectrum. These reagents are intended to detect mutations in the majority of Zellweger spectrum-associated loci simultaneously." + }, + { + "input": "Concept: CYP2C8*3 Allele (CYP2C8 gene)", + "output": "something described as human CYP2C8*3 allele is located in the vicinity of 10q23.33 and is approximately 33 kb in length. This allele, a variant form of the CYP2C8 wild-type allele, encodes cytochrome P450 2C8*3 protein. The CYP2C8*3 allele exhibits clinically-relevant SNPs (c.416G>A, c.1196A>G) in exons 3 and 8 that result in coding changes (R139K, K399R). These alterations in protein sequence severely decrease the enzymatic activity of the cytochrome P450 2C8*3 protein." + }, + { + "input": "Concept: Endocannabinoids (Organic Chemical)", + "output": "Organic Chemical described as endogenous compounds that bind to cannabinoid receptors, frequently neuroactive; chemically different from the plant derived cannabinoids." + }, + { + "input": "Concept: taxadiene 5a-hydroxylase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)", + "output": "Molecular Function described as catalysis of the reaction: AH(2) + O(2) + taxa-4,11-diene = A + H(2)O + taxa-4(20),11-dien-5alpha-ol." + }, + { + "input": "Concept: Retinoblastoma cM1b TNM Finding v7 (Retinoblastoma cM1 TNM Finding v7)", + "output": "something described as multiple lesions to sites other than CNS." + }, + { + "input": "Concept: Pausinystalia Pierre ex Beille, 1906 (Naucleeae)", + "output": "something described as a plant genus of the family RUBIACEAE. Members produce YOHIMBINE." + }, + { + "input": "Concept: Autologous Anti-BCMA-CAR-expressing CD8+ and CD4+ T-lymphocytes (Chimeric Antigen Receptor T-cells)", + "output": "Antineoplastic Immune Cell described as a preparation of ex vivo expanded autologous CD8+ and CD4+ T cells that have been genetically modified to express a chimeric antigen receptor (CAR) specific for human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-BCMA-CAR-expressing CD4+/CD8+ T lymphocytes FCARH143 specifically recognize and induce selective toxicity in BCMA-expressing tumor cells. BCMA, a tumor specific antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell activating factor (BAFF), is a member of the tumor necrosis factor (TNF) receptor superfamily (TNFRSF) and plays a key role in plasma cell survival. BCMA is found on the surfaces of plasma cells and overexpressed on malignant plasma cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C142807\" active clinical trials using this agent." + }, + { + "input": "Concept: Adverse Event Grade Code (Intellectual Product)", + "output": "Intellectual Product described as a coded value specifying the level of injury suffered by the subject for whom the event is reported." + }, + { + "input": "Concept: income maintenance (Financing, Organized)", + "output": "Idea or Concept described as insurance programs designed to compensate individuals based upon need due to unemployment, death of head of household, age, etc.; see narrower terms for disability or poverty based programs." + }, + { + "input": "Concept: Occlusive Dressing Technique (Techniques)", + "output": "Topical Route of Drug Administration described as administration by the topical route which is then covered by a dressing which occludes the area." + }, + { + "input": "Concept: Total Number of Prostate Tissue Cores (Finding)", + "output": "something described as an indication of the total number of prostate core specimens collected during a biopsy procedure." + }, + { + "input": "Concept: Abnormal Cardiac Study (Test Result)", + "output": "Test Result described as a history of having had an abnormal cardiac study." + }, + { + "input": "Concept: temozolomide (T [Preparations])", + "output": "Alkylating Drug [EPC] described as dacarbazine derivative; alkylating antineoplastic agent." + }, + { + "input": "Concept: Pharmaceutical Society (Societies)", + "output": "Professional Society described as societies whose membership is limited to pharmacists." + }, + { + "input": "Concept: Gas Output Problem (Finding)", + "output": "something described as problem associated with gas output." + }, + { + "input": "Concept: PHQ Screener Version - Anxiety Attack Tingling or Numbness (PHQ Screener Version Questionnaire Question)", + "output": "Intellectual Product described as patient Health Questionnaire Screener Version (PHQ Screener Version) Think about your last bad anxiety attack. Did you have tingling or numbness in parts of your body?" + }, + { + "input": "Concept: FATHER (Parental state)", + "output": "Family Group described as male parents, human or animal." + }, + { + "input": "Concept: Grade 2 Phlebitis, CTCAE (Phlebitis, CTCAE)", + "output": "something described as present" + }, + { + "input": "Concept: kringle domain binding (Molecular Function)", + "output": "protein domain specific binding described as interacting selectively and non-covalently with a kringle domain. Kringle domains are protein domains that fold into large loops stabilized by 3 disulfide linkages, and are important in protein-protein interactions with blood coagulation factors." + }, + { + "input": "Concept: 5-ht3 receptor antagonist (Organic Chemical)", + "output": "Pharmacologic Substance described as a type of drug used to treat certain types of irritable bowel syndrome and relieve nausea and vomiting. It is a type of antiemetic." + }, + { + "input": "Concept: NP 000537.3:p.R337H (TP53 Protein Variant)", + "output": "something described as a change in the amino acid residue at position 337 in the cellular tumor antigen p53 protein where arginine has been replaced by histidine." + }, + { + "input": "Concept: Posterior Urethral Valves Type 1 (Disease or Syndrome)", + "output": "something described as a posterior urethral valve extending from the vera montanum towards the distal meatus." + }, + { + "input": "Concept: cellular birth scar (Cell Component)", + "output": "something described as crater-like ring of chitinous scar tissue located on the surface of the daughter cell, in budding fungi, at the site of separation from the mother cell. It is formed after the newly emerged daughter cell separates, thereby marking the site of cytokinesis and septation." + }, + { + "input": "Concept: C-SSRS Already Enrolled Subjects - Number of Interrupted Suicide Attempts (Intellectual Product)", + "output": "Intellectual Product described as columbia-Suicide Severity Rating Scale Already Enrolled Subjects - Total number of interrupted attempts. (Prior to Study Entry)." + }, + { + "input": "Concept: 11-deoxycorticosterone aldose-ketose-isomerase activity (Molecular Function)", + "output": "intramolecular oxidoreductase activity, interconverting aldoses and ketoses described as catalysis of the reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al." + }, + { + "input": "Concept: yttrium Y 90 DOTA-biotin (Pharmacologic Substance)", + "output": "Radioconjugate described as a radioconjugate of biotin and yttrium Y 90 (Y-90) linked through the bifunctional macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) with radioimmunotherapy property. Biotin is a water-soluble B-complex vitamin, present in minute amounts in every living cell, while its level in cancerous tissue is higher than that of normal tissue. Y 90-DOTA-Biotin could be used in 3-step pre-targeting radioimmunotherapy that employs a tumor targeting antibody conjugated with streptavidin, the natural ligand of biotin." + }, + { + "input": "Concept: CAMPYLOBACTER SPP. (Medical Device)", + "output": "Medical Device described as campylobacter fetus serological reagents are devices that consist of antisera conjugated with a fluorescent dye used to identify Campylobacter fetus from clinical specimens or cultured isolates derived from clinical specimens. The identification aids in the diagnosis of diseases caused by this bacterium and provides epidemiological information on these diseases. Campylobacter fetus is a frequent cause of abortion in sheep and cattle and is sometimes responsible for endocarditis (inflammation of certain membranes of the heart) and enteritis (inflammation of the intestines) in humans." + }, + { + "input": "Concept: CSF2 gene (Colony-Stimulating Factor Gene)", + "output": "Gene or Genome described as this gene plays a role in the regulation of hematopoietic cellular processes." + }, + { + "input": "Concept: Abnormal immunoglobulin concentration (Immunology)", + "output": "Finding described as an abnormal deviation from normal levels of immunoglobulins in blood." + }, + { + "input": "Concept: congenital disorder eye (Eye)", + "output": "Vision Disorders described as a disorder of the eye that is present at birth. Representative examples include congenital cataract, congenital glaucoma, and astigmatism." + }, + { + "input": "Concept: iron-sulfur-molybdenum cofactor degradation (Molecular Function)", + "output": "cofactor catabolic process described as the chemical reactions and pathways resulting in the breakdown of iron-sulfur-molybdenum cofactor." + }, + { + "input": "Concept: mitotic anaphase A (Mitotic Anaphase)", + "output": "Mitotic Anaphase described as the cell cycle phase during which the kinetochore microtubules shorten as chromosomes move toward the spindle poles as part of mitosis." + }, + { + "input": "Concept: Audiovisual Materials (Manufactured Object)", + "output": "Manufactured Object described as materials using sight or sound to present information." + }, + { + "input": "Concept: Betalain (Piperidines)", + "output": "tyrosine described as compounds derived from TYROSINE via betalamic acid, including BETAXANTHINS and BETACYANINS. They are found in the Caryophyllales order of PLANTS and some BASIDIOMYCETES." + }, + { + "input": "Concept: Concentrate for Cutaneous Spray, Emulsion Dosage Form (Biomedical or Dental Material)", + "output": "Biomedical or Dental Material described as liquid preparation intended to be diluted in the specified liquid to obtain a cutaneous spray emulsion." + }, + { + "input": "Concept: Catheters, Intra-Arterial (catheter device)", + "output": "Vascular Catheters described as a hollow tube that is inserted into an artery." + }, + { + "input": "Concept: Product containing hydroxycarbamide (generic drug products begining with the letter H)", + "output": "Substance with ribonucleoside-diphosphate reductase inhibitor mechanism of action described as an anticancer drug that belongs to the family of drugs called antimetabolites." + }, + { + "input": "Concept: 9 Aminoacridine (Pharmacologic Substance)", + "output": "something described as highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with DNA; it is also used as an intracellular pH indicator." + }, + { + "input": "Concept: EDEMA GENERALIZED (MUSCLE SOFT, TISSUE)", + "output": "MUSCLE SOFT, TISSUE described as an extreme form of generalized edema with widespread and massive edema due to effusion of fluid into the extracellular space." + }, + { + "input": "Concept: 5q13.1 (Cell Component)", + "output": "something described as a chromosome band present on 5q" + }, + { + "input": "Concept: inositol phosphate phosphatase activity (phosphoric monoester hydrolase activity)", + "output": "Molecular Function described as catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate." + }, + { + "input": "Concept: Chart, Flow (Intellectual Product)", + "output": "Intellectual Product described as a diagram that shows the order of steps in a complex process." + }, + { + "input": "Concept: Body Box (Diagnostic Techniques, Cardiovascular)", + "output": "Pulmonary function tests described as recording of change in the size of a part as modified by the circulation in it." + }, + { + "input": "Concept: canonical holin activity (Molecular Function)", + "output": "Molecular Function described as a compound function consisting of the regulated formation of a pore via oligomerisation of an existing pool of subunits in the plasma membrane. The resulting channel activity directly allows release of a fully-folded phage-encoded endolysin (murein-degradase) from the cell." + }, + { + "input": "Concept: Prostata (Exocrine Glands)", + "output": "Specific site descriptor described as a gland in the male reproductive system. The prostate surrounds the part of the urethra (the tube that empties the bladder) just below the bladder, and produces a fluid that forms part of the semen." + }, + { + "input": "Concept: UPD2305A (MDS-UPDRS Questionnaire Question)", + "output": "MDS-UPDRS Questionnaire Question described as the Movement Disorder Society version of the Unified Parkinson's Disease Rating Scale - Right Hand Movements." + }, + { + "input": "Concept: tryptase (Protein Family)", + "output": "Serine Endopeptidases described as a family of neutral serine proteases with TRYPSIN-like activity. Tryptases are primarily found in the SECRETORY GRANULES of MAST CELLS and are released during mast cell degranulation." + }, + { + "input": "Concept: Manic Psychosis (Mental or Behavioral Dysfunction)", + "output": "Psychotic Disorders described as the manifestation of psychotic symptoms, such as hallucinations or delusions, in the presence of mania." + }, + { + "input": "Concept: Intrahepatic Bile Duct Cancer pT2b TNM Finding v7 (Finding)", + "output": "Intrahepatic Bile Duct Cancer pT2 TNM Finding v7 described as intrahepatic bile duct cancer with multiple tumors, with or without vascular invasion." + }, + { + "input": "Concept: IDS-C - Appetite (IDS-C Clinical Classification Question)", + "output": "something described as inventory of Depressive Symptomatology - Clinician-Rated - Please circle one response to each item that best describes the patient for the last seven days: Appetite (increased)." + }, + { + "input": "Concept: Stage IVA Adenoid Cystic Carcinoma of Oral Cavity (Adenoid cystic carcinoma of the oral cavity stage IV)", + "output": "Neoplastic Process described as stage IVA includes: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0). T4a: Oral cavity cancer with moderately advanced local disease. Tumor invades adjacent structures only (e.g., through cortical bone [mandible or maxilla] into deep [extrinsic] muscle of tongue [genioglossus, hyoglossus, palatoglossus, and styloglossus], maxillary sinus, skin of face). T1: Tumor 2 cm or less in greatest dimension. T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension. T3: Tumor more than 4 cm in greatest dimension. N0: No regional lymph node metastasis. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis." + }, + { + "input": "Concept: Combined (General Qualifier)", + "output": "General adjectival modifier described as made or joined or united into one or involving the joint activity of two or more." + }, + { + "input": "Concept: Urethral Stick Dosage Form (Urethral Dosage Form)", + "output": "Drug stick described as solid sterile single-dose preparation, usually rod-shaped and of a size adapted to the dimensions of the urethra, intended for insertion into the urethra. They may be prepared by compression or moulding." + }, + { + "input": "Concept: History, Modern 1601 (historical period)", + "output": "History described as the period of history from 1601 of the common era to the present." + }, + { + "input": "Concept: CDISC SEND Food and Water Consumption Test Name Terminology (Intellectual Product)", + "output": "CDISC SEND Terminology described as the terminology that includes concepts relevant to the Clinical Data Interchange Standards Consortium (CDISC) Standard for the Exchange of Non-clinical Data (SEND) food and water consumption test names." + }, + { + "input": "Concept: mouth; dry (Functions and Abnormal Functions of the Salivary Glands)", + "output": "Oropharyngeal disorders described as dryness of the mouth due to salivary gland secretion dysfunction." + }, + { + "input": "Concept: delta1-pyrroline-2-carboxylate reductase activity (Molecular Function)", + "output": "oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor described as catalysis of the reaction: L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+." + }, + { + "input": "Concept: SF36 v1.0 Standard - Question 9g (SF36 v1.0 Standard Questionnaire Question)", + "output": "SF36 v1.0 Standard Questionnaire Question described as the Short Form 36 (SF-36) Health Survey Standard, US Version 1.0 (SF36 v1.0 Standard) Question 9g." + }, + { + "input": "Concept: FAC00826 (FACT-C Version 4 Questionnaire Question)", + "output": "FACT-C Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Colorectal Version 4 (FACT-C Version 4) Functional Well-Being: I am enjoying the things I usually do for fun." + }, + { + "input": "Concept: requiredResponse (Idea or Concept)", + "output": "Idea or Concept described as the necessary reply to a question." + }, + { + "input": "Concept: ceramide transport (Cell Function)", + "output": "amide transport described as the directed movement of ceramides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid." + }, + { + "input": "Concept: injury to limb (Injury or Poisoning)", + "output": "Traumatic injury described as damage inflicted on any limb as the direct or indirect result of an external force, with or without disruption of structural continuity." + }, + { + "input": "Concept: Recurrent Oligodendroglioma (recurrent childhood astrocytoma or other tumor of glial origin)", + "output": "something described as the reemergence of oligodendroglioma in childhood after a period of remission." + }, + { + "input": "Concept: Isomerism, Right Atrial (Heart)", + "output": "Heart described as right atrial isomerism is characterized by bilateral triangular, morphologically right atrial, appendages, both joining the atrial chamber along a broad front with internal terminal crest." + }, + { + "input": "Concept: Scale (LOINC Axis)", + "output": "Conceptual Entity described as the metrological type (formal measurement type) of an observation. For example, some measurements are quantitative (the values for the measurement can be represented as solutions to an algebraic equation), ordinal (the values for the measurement can be placed in rank order), nominal (the values of the observation represent the names of the things that were seen), or narrative (the values of the observation are represented by free text expressions)." + }, + { + "input": "Concept: ICPCG (Health Care Related Organization)", + "output": "something described as international consortium of over 25 groups and multiple investigators pursuing collaborative research on the epidemiology of prostate cancer. The consortium was first promoted and supported by the NCI's Epidemiology and Genetics Program in 1995. Investigators are funded primarily by the NCI for their individual research projects (RO1s) while the National Institute for Human Genome Research contributes an intramural component. Current research focuses primarily on the discovery and characterization of prostate cancer susceptibility genes. Collaborations are established through communications and agreements with the participating groups." + }, + { + "input": "Concept: BACILLUS LICHENIFORMIS (Bacillus subtilis group)", + "output": "Bacillus subtilis group described as any bacterial organism that can be assigned to the species Bacillus licheniformis." + }, + { + "input": "Concept: Splicer (Manufactured Object)", + "output": "Manufactured Object described as a device designed to join pieces of a material into a continuous length." + }, + { + "input": "Concept: MUC1 Peptide-Poly-ICLC Vaccine (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as a vaccine preparation containing mucus 1 (MUC1) peptide and the adjuvant poly-ICLC with potential immunostimulatory and antineoplastic activities. Upon administration, MUC1 peptide-poly-ICLC adjuvant vaccine may induce the host immune system to mount a cytotoxic T cell response against MUC1-expressing tumor cells. MUC1, a tumor associated antigen normally present on the lining of the human colon, may be overexpressed and/or mutated in a variety of cancer cell types. The adjuvant poly-ICLC, a ligand for toll-like receptor-3, induces the release of cytokines which may help boost the immune response against MUC1. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C82417\" active clinical trials using this agent." + }, + { + "input": "Concept: Hypothalamic Hamartoblastoma, Hypopituitarism, Imperforate Anus, and Postaxial Polydactyly (Multiple congenital anomalies)", + "output": "something described as a pleiotropic disorder of human development that comprises hypothalamic HAMARTOMA; central and postaxial POLYDACTYLY; bifid EPIGLOTTIS; ANAL ATRESIA; and renal and other abnormalities. This disorder is associated with FRAMESHIFT MUTATIONS in the GLI3 gene which encodes the GLI3 protein, a KRUPPEL-LIKE TRANSCRIPTION FACTORS family member." + }, + { + "input": "Concept: HLA-B Gene Product (Histocompatibility Antigens Class I)", + "output": "something described as a protein encoded by the HLA-B gene." + }, + { + "input": "Concept: Recurrent Lip and Oral Cavity Carcinoma (Lip and Oral Cavity Carcinoma)", + "output": "Oral neoplasm malignant recurrent described as the reemergence of lip and/or oral cavity cancer after a period of remission. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C8037\" active clinical trials using this agent." + }, + { + "input": "Concept: Non-Malignant Neoplasm (Neoplasm by Special Category)", + "output": "Neoplasm by Special Category described as a category that includes benign neoplasms and neoplasms with uncertain malignant potential. The latter are characterized by clinicopathological features that are not benign, including some degree of mild or mild/moderate atypia/dysplasia, but lack overt malignant morphologic characteristics and there is no evidence of metastasis at the time of diagnosis." + }, + { + "input": "Concept: Pediculosis and other lice (Diseases Caused by Protozoa, Helminths and Other Parasites)", + "output": "Skin and subcutaneous arthropod and parasitic infestations described as a contagious infestation of parasitic insects found on the head (Pediculus humanus capitis), body (Pediculus humanus corporis), or pubic area (Pthirus pubis) that typically cause itching and rash." + }, + { + "input": "Concept: fibroma (Benign fibromatous neoplasm - category)", + "output": "Fibromatous neoplasm described as benign tumor of fibrous or fully developed connective tissue." + }, + { + "input": "Concept: Beds, Hydraulic, Radiography/Fluoroscopy (Medical Device)", + "output": "Medical Device described as hydraulic beds designed to permit radiographic and/or fluoroscopic procedures on a patient. These beds typically include radiolucent mattresses and supporting surfaces, raising and lowering mechanisms that do not intervene in the path between the radiation source and image intensifiers, and dimensions and clearances that facilitate placement of the x-ray tube head under the bed. Radiography/fluoroscopy hydraulic beds are mainly used for bedside procedures using mobile radiographic or fluoroscopic units." + }, + { + "input": "Concept: Absent/small ovary (Abnormal ovarian morphology)", + "output": "Finding described as aplasia or developmental hypoplasia of the ovary." + }, + { + "input": "Concept: Cand.cell-mediated mune rspn (General laboratory tests)", + "output": "General laboratory tests described as analyzing a client/patient's specimen sample to assess his or her cell-mediated immune response to candida albicans. Service is billed per test." + }, + { + "input": "Concept: KANAMYCIN A (Antibiotic)", + "output": "Organic Chemical described as the major component of the kanamycin complex, an aminoglycoside antibiotic isolated from Streptomyces kanamyceticus, with antibacterial activity." + }, + { + "input": "Concept: BIH - Benign intracranial hypertension (ENCEPHALOPATHY AND MISCELLANEOUS CNS DISORDERS)", + "output": "Disorder of soft tissue of body cavity described as an idiopathic disorder characterized by chronic increase in the intracranial pressure. It occurs predominantly in obese females of childbearing age. It is associated with papilledema." + }, + { + "input": "Concept: BCL2-adenovirus E1B 19kD-interacting protein 3, human (Amino Acid, Peptide, or Protein)", + "output": "Biologically Active Substance described as BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (194 aa, ~22 kDa) is encoded by the human BNIP3 gene. This protein plays a role in the promotion of both apoptosis and autophagy." + }, + { + "input": "Concept: High-performance Liquid Chromatography-Fluorescence (Laboratory Procedure)", + "output": "something described as an analytical technique where high performance liquid chromatography with a fluorescence detector is used to separate, identify, and quantify substances in a sample." + }, + { + "input": "Concept: creatine transmembrane transporter activity (cofactor transmembrane transporter activity)", + "output": "Molecular Function described as enables the transfer of creatine from one side of a membrane to the other. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." + }, + { + "input": "Concept: Isolation Gowns (Medical Device)", + "output": "Medical Device described as gowns designed to protect the wearer against physical contamination from patients with infectious diseases. These gowns are usually ankle-length and have long sleeves with elastic cuffs, full front and back coverage, and tie at the neck and waist. Isolation gowns are intended to fully cover the external clothing of the wearer (e.g., healthcare providers, healthcare facilities staff, and visitors). They are typically made of light-weight, fluid-resistant and breathable materials. Disposable non-woven (e.g., polypropylene) and reusable woven (e.g., polyester, cotton) isolation gowns are available." + }, + { + "input": "Concept: Congenital Cystic Adenomatoid Malformation, Type II (Congenital Abnormality)", + "output": "something described as this type is microcystic, characterized by multiple cysts of 0.5 to 2.5 cm." + }, + { + "input": "Concept: Medullary Thyroid Carcinoma Pathologic Regional Lymph Nodes TNM Finding v8 (Finding)", + "output": "something described as a pathologic finding about one or more characteristics of medullary thyroid carcinoma, following the rules of the TNM AJCC v8 classification system as they pertain to staging of regional lymph nodes." + }, + { + "input": "Concept: malignant neoplasm of the bone (Bones, Joints and Muscles)", + "output": "CLINICAL CLASSIFICATION OF NEOPLASMS OF THE MUSCULOSKELETAL SYSTEM AND SOFT TISSUES described as a primary or metastatic malignant neoplasm affecting the bone or articular cartilage." + }, + { + "input": "Concept: Evaluation of Patient's Distress (Psychological assessment)", + "output": "Psychological assessment described as the act of determining, usually through interviews and observation, the status of an individual's distress." + }, + { + "input": "Concept: occupational health services (Community Health Services)", + "output": "something described as health services for employees, usually provided by the employer at the place of work." + }, + { + "input": "Concept: ScheduledActivity.dateRange (Temporal Concept)", + "output": "something described as the date and time span specifying when the activity is scheduled to begin and end." + }, + { + "input": "Concept: Supraventricular Tachyarrhythmia ECG Assessment (Diagnostic Procedure)", + "output": "Diagnostic Procedure described as an electrocardiographic assessment of the abnormally fast cardiac rhythms originating above the ventricles." + }, + { + "input": "Concept: Abnormality of the globe (Abnormality of the eye)", + "output": "something described as a structural anomaly of the globe of the eye, or bulbus oculi." + }, + { + "input": "Concept: negative regulation of receptor-mediated endocytosis (Cell Function)", + "output": "regulation of receptor-mediated endocytosis described as any process that stops, prevents, or reduces the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport." + }, + { + "input": "Concept: polyacrylamide hydrogels (Biomaterials)", + "output": "something described as a transparent, biocompatible, non-resorbable, homogenous hydrogel containing 97.5% apyrogenic water and 2.5% of the cross-linked, synthetic polyacrylamide. Upon injection into the urethral submucosal tissue, the polyacrylamide hydrogel serves as a bulk forming agent and may possibly increase the strength of the urethral sphincter and thereby prevent or decrease stress-induced urinary incontinence." + }, + { + "input": "Concept: CT27 (Gene or Genome)", + "output": "CTCFL gene described as human CTCFL wild-type allele is located in the vicinity of 20q13.31 and is approximately 30 kb in length. This allele, which encodes transcriptional repressor CTCFL protein, is involved in both gene regulation and X-chromosome inactivation." + }, + { + "input": "Concept: tRNA (cytosine) methyltransferase activity (Genetic Function)", + "output": "tRNA methyltransferase activity described as catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine." + }, + { + "input": "Concept: Premedication (Pharmacotherapy)", + "output": "Therapeutic or Preventive Procedure described as preliminary administration of a drug preceding a diagnostic, therapeutic, or surgical procedure. The commonest types of premedication are antibiotics (ANTIBIOTIC PROPHYLAXIS) and anti-anxiety agents. It does not include PREANESTHETIC MEDICATION." + }, + { + "input": "Concept: Unmarried Mother (Mother)", + "output": "Mother described as consider also ADOLESCENT MOTHERS." + }, + { + "input": "Concept: STIFF SKIN SYNDROME (Rare Non-Neoplastic Disorder)", + "output": "Fibrosis of the skin described as a rare, autosomal dominant inherited syndrome caused by mutations in the FBN1 gene. It is characterized by hard and thickened skin, usually over the entire body, and limited joint motility." + }, + { + "input": "Concept: CRIDANIMOD (Organic Chemical)", + "output": "Organic Chemical described as a small molecule that can increase progesterone receptor (PR) expression, with potential antineoplastic adjuvant activity. Upon intramuscular administration, cridanimod is able to induce the expression of PR in endometrial cancer. This could increase the sensitivity of endometrial cancer cells to progestin monotherapy. In combination with a progestin, cancer cells could be eradicated through increased PR-mediated signaling, leading to an inhibition of luteinizing hormone (LH) release from the pituitary gland, via a negative feedback mechanism, and, eventually, an inhibition of estrogen release from the ovaries. This leads to an inhibition of cellular growth in estrogen-dependent tumor cells. In addition, this agent is able to increase the production and release of interferon (IFN) alpha and beta. PR is often downregulated in endometrial cancer and makes it resistant to progestin-mediated hormone therapy." + }, + { + "input": "Concept: Sarcoma of the Orbit cM0 TNM Finding v7 (Sarcoma of the Orbit Clinical Distant Metastasis TNM Finding v7)", + "output": "Finding described as sarcoma of the orbit without evidence of distant metastasis." + }, + { + "input": "Concept: PanIN/L-1A (Finding)", + "output": "Lesion described as a pancreatic lesion microscopically resembling pancreatic intraepithelial neoplasia-1A, however the neoplastic nature of the pathologic process has not been unambiguously established." + }, + { + "input": "Concept: Loss of Chromosome 10 (Chromosomal Loss)", + "output": "Chromosomal Loss described as a cytogenic abnormality that refers to loss of all or part of chromosome 10." + }, + { + "input": "Concept: Porcelain nails (Finding)", + "output": "Leukonychia described as a rare nail anomaly disorder characterized by complete white discoloration of the nails. Patients typically present white, chalky nails as an isolated finding, although other cutaneous or systemic manifestations could also be present. There is evidence the disease can be caused by homozygous or heterozygous mutation in the PLCD1 gene on chromosome 3p22-p21.3." + }, + { + "input": "Concept: Phosphate, Dihydroxyacetone (Organic Chemical)", + "output": "Biologically Active Substance described as an important intermediate in lipid biosynthesis and in glycolysis." + }, + { + "input": "Concept: Maxillary Sinus Cancer pT3 TNM Finding (Maxillary Sinus Cancer Pathologic Primary Tumor TNM Finding v7)", + "output": "Maxillary Sinus Cancer Pathologic Primary Tumor TNM Finding v7 described as maxillary sinus cancer with tumor invading any of the following: bone of the posterior wall of maxillary sinus, subcutaneous tissues, floor or medial wall of orbit, pterygoid fossa, or ethmoid sinuses." + }, + { + "input": "Concept: Degeneration, Striatonigral (cerebellar, brainstem and cranial nerve disorders)", + "output": "Degenerative Diseases, Central Nervous System described as a progressive neurodegenerative disorder caused by a disruption in the connection between the striatum and the substantia nigra. It is a type of multiple system atrophy (MSA). Signs and symptoms include rigidity, instability, impaired speech, and slow movements." + }, + { + "input": "Concept: PARRY ROMBERY DIS (Syndrome)", + "output": "something described as a rare disorder of unknown etiology, which is characterized by slowly progressive, unilateral facial atrophy of the skin, soft tissue, muscles, and underlying bony structures. Neurological, ocular, and oral symptoms are also often seen, including migraines, trigeminal neuralgia, enophthalmos, and dental and gingival abnormalities." + }, + { + "input": "Concept: Gallium Ga 68-NOTA-AE105 (Organic Chemical)", + "output": "Organic Chemical described as a radiotracer composed of AE105, an urokinase-type plasminogen activator receptor (uPAR) peptide antagonist, conjugated with the bifunctional, macrocyclic chelating agent 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA) and labeled with the radionuclide gallium Ga 68, with potential imaging activity using positron emission tomography (PET). Upon administration, the AE105 moiety of gallium Ga 68-NOTA-AE105 targets and binds, with high affinity, to uPAR expressed on tumor cells. Upon PET imaging, uPAR-expressing tumor cells can be visualized and the degree of tumor aggressiveness can be assessed. uPAR expression is correlated with increased tumor invasiveness and aggressiveness, as well as a poor prognosis." + }, + { + "input": "Concept: Signal Loss (Device Evaluation Result)", + "output": "Finding described as problems due to the loss or weakening of an electrical signal or signals." + }, + { + "input": "Concept: hypersensitivity reaction (Adverse effects, not elsewhere classified)", + "output": "Immunologic hypersensitivity described as hypersensitivity; a local or general reaction of an organism following contact with a specific allergen to which it has been previously exposed and to which it has become sensitized." + }, + { + "input": "Concept: plasma cell tumor (Neoplastic Process)", + "output": "Immunoproliferative neoplasm described as a clonal proliferation of immunoglobulin-secreting plasma cells. This category includes plasma cell myeloma, plasma cell leukemia, plasmacytoma, monoclonal immunoglobulin deposition disease, and monoclonal gammopathy of undetermined significance." + }, + { + "input": "Concept: prephenate dehydrogenase activity (oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)", + "output": "oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor described as catalysis of the reaction: NAD(+) + prephenate = (4-hydroxyphenyl)pyruvate + CO(2) + NADH." + }, + { + "input": "Concept: SSL2-core TFIIH complex portion of holo TFIIH complex (transcription factor TFIIH core complex)", + "output": "something described as the core TFIIH complex when it is part of the general transcription factor TFIIH." + }, + { + "input": "Concept: SPINNER, SLIDE, AUTOMATED (Medical Device)", + "output": "Medical Device described as an automated slide spinner is a device that prepares automatically a blood film on a microscope slide using a small amount of peripheral blood (blood circulating in one of the body's extremities, such as the arm)." + }, + { + "input": "Concept: Antigens, Blood Group (Hematology analyte)", + "output": "something described as sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties." + }, + { + "input": "Concept: Retreatment of Progressive Local Disease with Brachytherapy (Brachytherapy)", + "output": "Brachytherapy described as brachytherapy given as retreatment of locally progressive cancer." + }, + { + "input": "Concept: COXEN Score 28 (COXEN Sensitivity Scale)", + "output": "something described as a score of 28 on the COXEN Sensitivity Scale." + }, + { + "input": "Concept: regulation of tubulin deacetylation (regulation of protein deacetylation)", + "output": "something described as any process that modulates the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid." + }, + { + "input": "Concept: DART (Toxicology)", + "output": "Biomedical Occupation or Discipline described as the branch of toxicology that deals with adverse effects of chemical, physical or biological agents on reproduction and development." + }, + { + "input": "Concept: Interstitial edema (Blood, Heart and Circulation)", + "output": "Engorgement, Congestion and Extravasation described as swelling from excessive accumulation of serous fluid in tissue." + }, + { + "input": "Concept: VZOS (Quantitative Concept)", + "output": "Observed Volume of Distribution described as the volume of distribution associated with the terminal slope following intravascular administration, calculated using the observed value of the last non-zero concentration, divided by the surface area." + }, + { + "input": "Concept: Spinal Accessory Nerves (Neural tree organ)", + "output": "Peripheral Nervous System described as neural tree organ, each instance of which supplies some sternocleidomastoid and trapezius muscles." + }, + { + "input": "Concept: Caput of sperm (Cell Component)", + "output": "Cell Component described as the part of the late spermatid or spermatozoon that contains the nucleus and acrosome." + }, + { + "input": "Concept: MSQL1-Have Had Trouble With Your Memory (Intellectual Product)", + "output": "something described as multiple Sclerosis Quality of Life-54 Instrument - How much of the time during the past 4 weeks: Have you had trouble with your memory?" + }, + { + "input": "Concept: B2AR (ADRB2 gene)", + "output": "Gene or Genome described as human ADRB2 wild-type allele is located within 5q31-q32 and is approximately 2 kb in length. This allele, which encodes beta-2 adrenergic receptor protein, plays a role in the regulation of both calcium channel complex regulation and adenylyl cyclase activity. A variety of polymorphic forms of the gene are associated with nocturnal asthma, obesity and type 2 diabetes. These variants are frequently generated by point mutations and downregulation of the gene." + }, + { + "input": "Concept: Animal Culling (Animal Husbandry)", + "output": "Veterinary physicians procedure AND/OR service described as selection and removal of individuals from a population or group. Culling is a common strategy with livestock and wildlife, used to control and eradicate diseases or pests, control population size, select for desired genetic characteristics, and maximize economic profit." + }, + { + "input": "Concept: Regurgitating (Vomiting)", + "output": "something described as functions of moving food or liquid in the reverse direction to ingestion, from stomach to oesophagus to mouth without expelling it." + }, + { + "input": "Concept: 33* (Body Location or Region)", + "output": "something described as the part of area 33 located between area 24 and the corpus callosum in the anterior cingulate cortex of the human ( Vogt-2012 ) and of the rat ( Vogt-2013 ). It has no equivalent in the macaque ( Vogt-1987 ) or the mouse ( Vogt-2013 ). In NeuroNames it is designated 33* to avoid confusion with the superstructure area 33, which has other parts besides 33*." + }, + { + "input": "Concept: Bacteroides faecis (Bacteroides)", + "output": "Bacteroides described as a species of anaerobic, gram-negative, rod shaped bacteria assigned to the phylum Bacteroidetes. This species is non-motile, spore forming, oxidase, urease and catalase negative, indole positive and hydrolyzes esculin. B. faecis was originally isolated from human feces." + }, + { + "input": "Concept: Scissors, Surgical, Bronchus, Endoscopic (Surgical Scissors)", + "output": "something described as surgical scissors designed to cut tissue in the bronchi through the working channel of a bronchoscope These scissors are typically handheld, manual instruments with two metallic (e.g., stainless steel), very thin blades with sharp tips and a long flexible shank; usually, a movable blade slides toward a stationary blade (i.e., shearing action). The blades are attached through the shank to handles at the proximal end conformed as rings to facilitate holding and operating with the fingers. Bronchoscopic scissors are used to cut and excise tissue from the bronchi, typically to widen the lumen or to excise small tumors." + }, + { + "input": "Concept: FACIT-F Version 4 - Worry My Condition Will Get Worse (FACIT-F Version 4 Questionnaire Question)", + "output": "something described as functional Assessment of Chronic Illness Therapy-Fatigue Version 4 - Emotional Well-Being: I worry that my condition will get worse." + }, + { + "input": "Concept: 3,5-xylenol methylhydroxylase activity (Molecular Function)", + "output": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen described as catalysis of the reaction: 3-hydroxytoluene + NADH + O2 = NAD+ + OH- + 3-hydroxybenzyl alcohol." + }, + { + "input": "Concept: Ontario (Province)", + "output": "Region of Canada described as a province of Canada lying between the provinces of Manitoba and Quebec. Its capital is Toronto. It takes its name from Lake Ontario which is said to represent the Iroquois oniatariio, beautiful lake." + }, + { + "input": "Concept: anti-CD22 CAR-expressing T lymphocytes (Antineoplastic Immune Cell)", + "output": "Chimeric Antigen Receptor T-cells described as a preparation of human T lymphocytes transduced with a recombinant viral vector encoding a chimeric T-cell receptor (chimeric antigen receptor or CAR) consisting of one or more binding domains targeting the tumor-associated antigen (TAA) CD22 and fused to one or more co-stimulatory, TCR-signaling domains, with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CD22 CAR-expressing T lymphocytes, express anti-CD22-CAR on their cell surfaces and bind to the CD22 antigen on tumor cell surfaces. Subsequently, CD22-expressing B cells are lysed. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed on malignant B cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C128556\" active clinical trials using this agent." + }, + { + "input": "Concept: Threonine modified diet (Modified amino acid diet)", + "output": "something described as increase or decrease in threonine content of the diet." + }, + { + "input": "Concept: Porphyromonas Shah and Collins 1988 emend. Willems and Collins 1995 (Bacteroidaceae)", + "output": "Anaerobic Gram-negative bacillus described as a genus of gram-negative, anaerobic, nonsporeforming, nonmotile rods or coccobacilli. Organisms in this genus had originally been classified as members of the BACTEROIDES genus but overwhelming biochemical and chemical findings indicated the need to separate them from other Bacteroides species, and hence, this new genus was created." + }, + { + "input": "Concept: specification of decreased petal number (specification of petal number)", + "output": "Biologic Function described as any process that reduces the number of petals produced in a developing flower." + }, + { + "input": "Concept: post-synaptic specialization organization (Cell Function)", + "output": "Cell Function described as a process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic specialization, a structure that lies adjacent to the cytoplasmic face of the postsynaptic membrane." + }, + { + "input": "Concept: Oxygen Analyzer (Medical Device)", + "output": "something described as a device designed to measure the concentration of oxygen in a gas mixture." + }, + { + "input": "Concept: CSS0907 (Intellectual Product)", + "output": "C-SSRS Screening Questionnaire Question described as columbia-Suicidality Severity Rating Scale Screening (C-SSRS Screening) How many times have you had these thoughts?" + }, + { + "input": "Concept: Left basal segmental artery (Left lower lobar artery)", + "output": "Basal segmental artery described as basal segmental artery, each instance of which supplies the basal segments of the lower lobe of some left lung." + }, + { + "input": "Concept: Magnetometer Device (Manufactured Object)", + "output": "Measuring Instruments, Magnetic described as a device designed to measure the strength of a magnetic field." + }, + { + "input": "Concept: Reimbursement Data Management Systems (Medical Device)", + "output": "something described as information systems designed to record, process, and display data related to the rules and terminology of patient treatment episode codes (i.e., coding) and the appropriate reimbursement calculations. These systems consist of hardware, including computerized workstations and peripheral devices such as high-capacity storage devices and printers, and software packages specifically intended for coding and filing reimbursement claims according to guidelines, rules, and standards. Coding/reimbursement data management information systems streamline and improve the accuracy of coding, claims, and billing (i.e., reimbursement). These information systems may function as stand-alone systems or may be integrated in a hospitalwide data management information system network." + }, + { + "input": "Concept: Inadequate boron intake (Finding)", + "output": "something described as lower intake of boron compared to established reference standards or recommendations based on physiological needs (Source: International Dietetics and Nutrition Terminology (IDNT) Reference Manual, edition 4; ISBN #978-0-88091-467-3)" + }, + { + "input": "Concept: Liver/Gallbladder (Tissue specimen)", + "output": "something described as a specimen that contains the liver and gallbladder." + }, + { + "input": "Concept: Allergy Syringes (Medical Device)", + "output": "Medical Device described as plunger syringes designed for subcutaneous injection of precise low-volume doses (typically 0.25 to 2 mL) of tuberculin and/or sensitivity (allergy) tests; they may also be used for other subcutaneous injections (e.g., rubella vaccine). These syringes typically have a small-diameter, low-volume cylinder, usually 1 mL in size, that is accurately calibrated in fractions of milliliter or cubic centimeter using permanent lines on its barrel. Tuberculin/allergy syringes usually are available with short-length, very-small-gauge needles (25 to 28 gauge is typical) attached or fixed to their tip that may be either centered or eccentric with the syringe barrel." + }, + { + "input": "Concept: IL-23 complex (protein-containing complex)", + "output": "protein-containing complex described as a protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space." + }, + { + "input": "Concept: Heterochromatin protein 1 homolog gamma (Amino Acid, Peptide, or Protein)", + "output": "Transcription Regulatory Protein described as chromobox protein homolog 3 (183 aa, ~21 kDa) is encoded by the human CBX3 gene. This soluble, nuclear protein plays a role in epigenetic repression of chromatin and association of heterochromatin with the inner nuclear membrane." + }, + { + "input": "Concept: ALDOSTERONISM, PRIMARY (Conn Syndrome)", + "output": "Endocrine Syndrome described as an endocrine disorder characterized by excessive production of aldosterone by the adrenal glands. Causes include adrenal gland adenoma and adrenal gland hyperplasia. The overproduction of aldosterone results in sodium and water retention and hypokalemia. Patients present with high blood pressure, muscle weakness, and headache." + }, + { + "input": "Concept: CHMTIDCD (Code)", + "output": "Intellectual Product described as the unique identifier code assigned by the manufacturer or distributor to a specific quantity of chemical challenge agent. This may include batch number, lot number, batch/lot number, etc." + }, + { + "input": "Concept: 2,4-dichlorobenzoate metabolism (Molecular Function)", + "output": "monocarboxylic acid metabolic process described as the chemical reactions and pathways involving 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs)." + }, + { + "input": "Concept: IMPORTIN BETA-1 (Gene or Genome)", + "output": "something described as this gene is involved in nuclear import." + }, + { + "input": "Concept: Childhood Ovarian Mixed Germ Cell Tumor (Neoplastic Process)", + "output": "Childhood Mixed Germ Cell Tumor described as a mixed germ cell tumor that arises from the ovary and occurs in children." + }, + { + "input": "Concept: host organism (cellular anatomical entity)", + "output": "Other Organism Groupings described as any organism in which another organism, especially a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection." + }, + { + "input": "Concept: PODCI Pediatric Parent-Reported Version - Write With a Pencil (Intellectual Product)", + "output": "something described as pediatric Outcomes Data Collection Instrument, Pediatric Parent-Reported - During the last week, was it easy or hard for your child to: Write with a pencil?" + }, + { + "input": "Concept: Sezary's Disease (Neoplastic Process)", + "output": "Lymphoma described as a form of cutaneous T-cell lymphoma manifested by generalized exfoliative ERYTHRODERMA; PRURITUS; peripheral lymphadenopathy, and abnormal hyperchromatic mononuclear (cerebriform) cells in the skin, LYMPH NODES, and peripheral blood (Sezary cells)." + }, + { + "input": "Concept: BRCAPRO (Mathematical Model)", + "output": "something described as a computer program that uses statistics to predict whether a person has an inherited mutation (change) in the BRCA1 and BRCA2 genes. People who have certain mutations in these genes have a higher than normal risk of breast, ovarian, prostate, and other types of cancer. The program is based on personal and family medical histories of breast and ovarian cancer." + }, + { + "input": "Concept: Games, Video (Play and Playthings)", + "output": "Manufactured Object described as a form of interactive entertainment in which the player controls electronically generated images that appear on a video display screen. This includes video games played in the home on special machines or home computers, and those played in arcades." + }, + { + "input": "Concept: cellular response to amphetamine (Cell Function)", + "output": "cellular response to drug described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine." + }, + { + "input": "Concept: Follistatin-Like Protein 3 (Amino Acid, Peptide, or Protein)", + "output": "something described as a secreted glycoprotein of approximately 28 kD, encoded by the FLRG or FSTL3 gene." + }, + { + "input": "Concept: stigmasterol UDP-glucosyltransferase activity (Molecular Function)", + "output": "sterol glucosyltransferase activity described as catalysis of the reaction: UDP-glucose + stigmasterol = UDP + O-glucosyl-stigmasterol." + }, + { + "input": "Concept: Structure of tentorium cerebelli (Brain part)", + "output": "Meninges, Dural Sinuses and Epidural Spaces described as a laminar extension of the dura mater that lies between, and separates, the cerebrum and the cerebellum." + }, + { + "input": "Concept: Blepharoclonus (Disease or Syndrome)", + "output": "Seizures and seizure disorders NEC described as marked, involuntary jerking of the eyelids. []" + }, + { + "input": "Concept: DRRI-2 - A: Injured by Person - Adulthood (DRRI-2 Questionnaire Question)", + "output": "something described as deployment Risk and Resilience Inventory-2 (DRRI-2) Before deployment: I was seriously physically injured by another person (for example, hit or beaten up) during adulthood (age 18 or later)." + }, + { + "input": "Concept: administrativeGenderCode (Intellectual Product)", + "output": "something described as a coded value specifying the physical or societal properties by which male is distinguished from female." + }, + { + "input": "Concept: Truncus arteriosus of fetus (Primitive heart tube structure)", + "output": "Embryonic Structures described as the arterial trunk arising from the fetal heart. During development, it divides into AORTA and the PULMONARY ARTERY." + }, + { + "input": "Concept: Cip1-Interacting Zinc Finger Protein (Cell Cycle Proteins)", + "output": "Amino Acid, Peptide, or Protein described as cip1-interacting zinc finger protein (898 aa, ~100 kDa) is encoded by the human CIZ1 gene. This protein plays a role in the modulation of both cyclin-dependent kinase inhibitor 1 protein localization and DNA replication." + }, + { + "input": "Concept: Vulvar Alveolar Rhabdomyosarcoma (Neoplastic Process)", + "output": "Alveolar rhabdomyosarcoma described as an extremely rare malignant mesenchymal neoplasm of the vulva exhibiting skeletal muscle differentiation with an alveolar pattern." + }, + { + "input": "Concept: REGENERATIONS (Organ or Tissue Function)", + "output": "anatomical structure development described as the physiological renewal, repair, or replacement of tissue." + }, + { + "input": "Concept: Enzyme Unit (Quantitative Concept)", + "output": "Unit of Catalytic Activity described as a unit of catalytic activity measurement defined as the quantity of a particular enzyme that catalyzes the transformation of one micromole of the substrate per minute under standard conditions for specified assay system." + }, + { + "input": "Concept: CARDIOMEGALY, IDIOPATHIC (Disease or Syndrome)", + "output": "Cardiomyopathies described as a disease of the heart muscle or myocardium proper whose cause is unknown." + }, + { + "input": "Concept: SU014813 (Pharmacologic Substance)", + "output": "something described as an orally-active, tyrosine kinase receptor inhibitor with potential antitumor activity. SU014813 binds to and inhibits the phosphorylation of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor (PDGFR) alpha and beta, c-Kit and Fms-related tyrosine kinase 3 (Flt-3). This leads to an inhibition of cellular proliferation and angiogenesis and an induction of apoptosis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61507\" active clinical trials using this agent." + }, + { + "input": "Concept: Toxicology Screening Urine Analyzers (Analyzers, Laboratory, Urine, Semiautomated)", + "output": "Medical Device described as semiautomated laboratory analyzers designed to perform rapid qualitative immunology (e.g., using immunochromatography) tests to determine the presence of certain analytes that are considered drugs of abuse (e.g., barbiturates, amphetamines, oxycodone, propoxyphene) when the concentrations are above a pre-determined cutoff value in a urine sample. These analyzers may consist of a combination of a cassette with several wells for the urine samples and a filter photometer reader (i.e., a colorimeter); other technologies involving enzyme immunoassays and spectrophotometers may also be used. Typically the urine samples are placed in the cassette wells where the reagents are present, resulting in colors the intensity of which depends on the presence and concentration of each drug. The reader scans the cassette, processes the information using dedicated software, and displays and/or prints the results as positive or negative for each of the substances in a few minutes. Toxicology screening urine analyzers provide only preliminary results that should be confirmed using more specific analytical tests (e.g., high-performance liquid chromatography); they are not intended for use as point-of-care analyzers." + }, + { + "input": "Concept: 2,4,4-trimethylpentanoate-CoA ligase activity (acid-thiol ligase activity)", + "output": "something described as catalysis of the reaction: 2,4,4-trimethylpentanoate + CoASH = 2,4,4-trimethylpentanoyl-CoA + OH-." + }, + { + "input": "Concept: Node, Hensen's (Embryonic Structure)", + "output": "Embryonic Structure described as the knot at the tip of the PRIMITIVE STREAK." + }, + { + "input": "Concept: Receptors, Vascular Endothelial Growth Factor (Amino Acid, Peptide, or Protein)", + "output": "Growth Factor Receptors described as a family of closely related RECEPTOR PROTEIN-TYROSINE KINASES that bind vascular endothelial growth factors. They share a cluster of seven extracellular IG-LIKE DOMAINS which are important for ligand binding. They are highly expressed in vascular endothelial cells and are critical for the physiological and pathological growth, development and maintenance of blood and lymphatic vessels." + }, + { + "input": "Concept: Service, Diagnostic (Preventive Health Services)", + "output": "something described as organized services for the purpose of providing diagnosis to promote and maintain health." + }, + { + "input": "Concept: SOCCD (Intellectual Product)", + "output": "something described as a coded value specifying the primary system organ class from the Medical Dictionary for Regulatory Activities (MedDRA)." + }, + { + "input": "Concept: Caregiver emotional health status (Caregiver health status)", + "output": "Emotional state characteristics described as emotional well-being of a family care provider while caring for a family member" + }, + { + "input": "Concept: FAC050-I Am Able to Enjoy Life (NCCN-FACT FOSI-18 Version 2 Questionnaire Question)", + "output": "NCCN-FACT FOSI-18 Version 2 Questionnaire Question described as national Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Ovarian Symptom Index-18 Version 2 (NCCN-FACT FOSI-18 Version 2) I am able to enjoy life." + }, + { + "input": "Concept: positive regulation of SECIS binding (positive regulation of mRNA binding)", + "output": "Molecular Function described as any process that activates or increases the frequency, rate or extent of selenocysteine insertion sequence binding." + }, + { + "input": "Concept: Every 9 hours (Schedule Frequency)", + "output": "something described as every nine hours." + }, + { + "input": "Concept: Preference, Food (preference)", + "output": "something described as the selection of one food over another." + }, + { + "input": "Concept: Prostate Acinar Adenocarcinoma, Pseudohyperplastic Variant (Prostate Acinar Adenocarcinoma)", + "output": "Neoplastic Process described as a variant of acinar prostate adenocarcinoma characterized by the presence of neoplastic large glands that resemble the benign, non-neoplastic prostate glands." + }, + { + "input": "Concept: FANA (Laboratory Findings: Serology)", + "output": "Laboratory: serology described as FANA (Fluorescent Antinuclear Antibody): a test in which standard nuclei are washed with patient serum and then stained with fluorescent labeled antihuman globulin. The pattern of staining may suggest different connective tissue diseases, e.g., 1) diffuse pattern, found in many diseases; 2) rim pattern, more suggestive of SLE; 3) speckled pattern, suggestive of MCTD, SLE and others; 4) nucleolar pattern, suggestive of PSS." + }, + { + "input": "Concept: protein-phosphoribosyl dephospho-coenzyme A linkage via O-(phosphoribosyl dephospho-coenzyme A)-L-serine (protein-phosphoribosyl dephospho-coenzyme A linkage)", + "output": "protein-phosphoribosyl dephospho-coenzyme A linkage described as the formation of a protein-phosphoribosyl dephospho-coenzyme A linkage via O-(phosphoribosyl dephospho-coenzyme A)-L-serine." + }, + { + "input": "Concept: SCTESTCD (CDISC SDTM Terminology)", + "output": "CDISC SDTM Terminology described as terminology codelist used for Subject Characteristic Codes within the Clinical Data Interchange Standards Consortium Study Data Tabulation Model." + }, + { + "input": "Concept: malignant ameloblastoma (Malignant Neoplasms)", + "output": "Metastatic Neoplasm described as a rare, well differentiated, cytologically benign ameloblastoma which paradoxically metastasizes." + }, + { + "input": "Concept: modification by virus of host transcription (Cell Function)", + "output": "something described as any process in which a virus modulates the frequency, rate or extent of its host's transcription." + }, + { + "input": "Concept: Asparagus officinalis, homeopathic preparation (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as garden asparagus." + }, + { + "input": "Concept: Electronic Nicotine Product Device (Manufactured Object)", + "output": "Personal Vaporizer described as a battery-powered electronic device designed to atomize a nicotine-containing liquid solution for inhalation." + }, + { + "input": "Concept: acute lymphocytic leukemia, adult untreated (stage, adult acute lymphoblastic leukemia)", + "output": "something described as a finding of acute lymphoblastic leukemia in adulthood that has not been treated." + }, + { + "input": "Concept: pN0(mol+) Carcinoma of the Breast v6 (Finding)", + "output": "Finding described as breast cancer with positive molecular findings by RT-PCR, but without histological or immunohistochemical evidence of regional lymph node involvement." + }, + { + "input": "Concept: macula (Body Part, Organ, or Organ Component)", + "output": "something described as an area of densely packed modified epithelial cells lining the wall of the distal convoluted tubule of the kidney that is adjacent to the afferent arteriole just before it enters the glomerulus and is in direct apposition to the juxtaglomerular cells." + }, + { + "input": "Concept: Tables, X-Ray (Tables, Imaging)", + "output": "Tables, Imaging described as a radiologic table is a device intended for medical purposes to support a patient during radiologic procedures. The table may be fixed or tilting and may be electrically powered." + }, + { + "input": "Concept: detection of electrical stimulus (detection of abiotic stimulus)", + "output": "detection of abiotic stimulus described as the series of events by which an electrical stimulus is received and converted into a molecular signal." + }, + { + "input": "Concept: Stage II Appendiceal Carcinoma AJCC v8 (Neoplastic Process)", + "output": "Neoplastic Process described as stage II includes: IIA: T3, N0, M0; IIB: T4a, N0, M0; IIC: T4b, N0, M0. T3: Tumor invades through the muscularis propria into the subserosa or the mesoappendix. T4a: Tumor invades through the visceral peritoneum, including the acellular mucin or mucinous epithelium involving the serosa of the appendix or serosa of the mesoappendix. T4b: Tumor directly invades or adheres to adjacent organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis." + }, + { + "input": "Concept: split hand-cleft lip/palate and ectodermal (SCE) dysplasia (Multiple malformation syndrome with facial-limb defects as major feature)", + "output": "Ectodermal dysplasia with hair-tooth-nail-sweating defect described as ectrodactyly of the hands and feet (lobster claw anomaly), nasolacrimal duct obstruction, cleft lip and palate, and urogenital abnormalities are the cardinal features. Mental retardation, conductive hearing loss, and abnormalities of the ears and face are occasionally associated. The phenotype overlaps in parts that of the ectrodactyly-mandibulo-facial dysostosis syndrome." + }, + { + "input": "Concept: Analyzers, Point-of-Care (Analyzer, device)", + "output": "something described as analyzers designed to be used at the point of patient care, wherever medical care is needed. Most of these analyzers are used in places where a quick result is needed and where it is possible to perform the assay soon after the sample is obtained, using samples taken directly from the patient, such as whole blood or urine, usually without any manipulation (e.g., centrifugation) before the introduction of the sample in to the analyzer. Some of these analyzers incorporate computerized data management capabilities for storage and retrieval of test results and may also incorporate software programs (e.g., to calculate anticoagulant dosages). These analyzers are handheld portable or mobile devices and do not require permanent dedicated space. Point-of-care analyzers may be operated by healthcare providers (e.g., nurses) or patients with a minimum of, or without, any previous training. Typical places for point-of-care analyzer use are intensive care units, emergency departments, operating rooms, or at the bedside. Some point-of- care analyzers can also be used at home." + }, + { + "input": "Concept: BEBQ0205 (BEBQ Retrospective Version Questionnaire Question)", + "output": "Intellectual Product described as baby Eating Behaviour Questionnaire - Retrospective - My baby finished feeding quickly." + }, + { + "input": "Concept: Methionine (Amino acids measurement)", + "output": "SPECIFIC SUBSTANCE CHEMISTRY TESTS described as a measurement of the methionine in a biological specimen." + }, + { + "input": "Concept: Analyzers, Laboratory, Milk (Analyzers, Laboratory)", + "output": "something described as laboratory analyzers that provide a quantitative measurement of various components of milk. These analyzers can measure nutrients such as fat, protein and total carbohydrate content as well as provide calculations of the total solids and energy content contained in the milk. Milk analyzers commonly use mid-infrared transmission spectroscopy as the analysis method." + }, + { + "input": "Concept: LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN, DENDRITIC CELL-SPECIFIC (Gene or Genome)", + "output": "Gene or Genome described as this gene is involved in antigen processing and immune responses." + }, + { + "input": "Concept: SCF-Dia2/Pof3 ubiquitin ligase complex location (SCF ubiquitin ligase complex)", + "output": "something described as an SCF ubiquitin ligase complex in which the F-box protein is Dia2 in S. cerevisiae (Pof3 in S. pombe)." + }, + { + "input": "Concept: POLY A BINDING PROTEIN I (Amino Acid, Peptide, or Protein)", + "output": "something described as a poly(A) binding protein that has a variety of functions such as mRNA stabilization and protection of RNA from nuclease activity. Although poly(A) binding protein I is considered a major cytoplasmic RNA-binding protein it is also found in the CELL NUCLEUS and may be involved in transport of mRNP particles." + }, + { + "input": "Concept: ENDOCRINE DIAG TECHNICS (Diagnosis)", + "output": "something described as methods and procedures for the diagnosis of diseases or dysfunction of the endocrine glands or demonstration of their physiological processes." + }, + { + "input": "Concept: Unit of Weight (Quantitative Concept)", + "output": "Quantitative Concept described as an indication of the type of unit of measure being used to express a weight." + }, + { + "input": "Concept: malignant neoplasm of upper third of esophagus (Neoplasm of upper third of esophagus)", + "output": "Malignant Neoplasms described as a primary or metastatic malignant neoplasm involving the upper third segment of the esophagus." + }, + { + "input": "Concept: positive regulation by symbiont of host adenylate cyclase-mediated signal transduction (modulation by symbiont of host adenylate cyclase-mediated signal transduction)", + "output": "modulation by symbiont of host adenylate cyclase-mediated signal transduction described as any process in which an organism activates, maintains or increases the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." + }, + { + "input": "Concept: up-regulation of protein localization to nucleus (regulation of protein localization to nucleus)", + "output": "positive regulation of cellular protein localization described as any process that activates or increases the frequency, rate or extent of protein localization to nucleus." + }, + { + "input": "Concept: Streptococcus enterococcus group (BACTERIA AND RICKETTSIAE)", + "output": "Catalase-negative Gram-positive coccus described as a genus of Gram-positive, facultative anaerobic, lactic acid bacteria in the phylum Firmicutes." + }, + { + "input": "Concept: Iodine I 123 Anti-CEA Recombinant Diabody T84.66 (Amino Acid, Peptide, or Protein)", + "output": "Radioimmunoconjugates described as a radioimmunoconjugate comprised of a recombinant scFv dimer diabody of a monoclonal antibody against human carcinoembryonic antigen (CEA) labeled with iodine I 123 (I-123) with potential radioimmunolocalization applications. The antibody moiety of iodine I 123 anti-CEA recombinant diabody T84.66 binds to cells expressing CEA, selectively delivering I-123 upon cellular internalization and allowing the scintigraphic imaging of CEA-expressing tumor cells. CEA, a tumor associated antigen, is overexpressed in many cancer types, including gastrointestinal, breast, non-small cell lung, and thyroid cancers. Compared to whole monoclonal antibodies, diabody fragments offer the advantages of rapid tumor targeting, rapid blood clearance, more uniform tumor distribution, and a lower potential for eliciting an immune response." + }, + { + "input": "Concept: Detailed (Conceptual Entity)", + "output": "Qualitative Concept described as particulars considered individually and in relation to a whole." + }, + { + "input": "Concept: larynx; fissure, congenital (Laryngeal and tracheal disorders congenital)", + "output": "Larynx described as a rare congenital abnormality in the laryngo-tracheal wall. It results from the incomplete development of the tracheoesophageal septum. Signs and symptoms include coughing, cyanosis, repeated pulmonary infections, and failure to gain weight." + }, + { + "input": "Concept: Sch-900776 (Pharmacologic Substance)", + "output": "Chk1 Inhibitor described as an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. Chk1 inhibitor MK-8776 specifically binds to and inhibits Chk1, which may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases to undergo DNA repair prior to entry into mitosis; tumor cells may thus be sensitized to the DNA-damaging effects of ionizing radiation and alkylating chemotherapeutic agents. Chk1 is an ATP-dependent serine-threonine kinase that in response to DNA damage phosphorylates cdc25 phosphatases, resulting in inhibitory tyrosine phosphorylation of CDK-cyclin complexes and cell cycle arrest." + }, + { + "input": "Concept: FACT-B Version 4 - I Get Support From My Friends (FACT-B Version 4 Questionnaire Question)", + "output": "FACT-B Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Breast Version 4 (FACT-B Version 4) Social/Family Well-Being: I get support from my friends." + }, + { + "input": "Concept: Retroperitoneal hemorrhage (Peritoneal and retroperitoneal haemorrhages)", + "output": "Pathologic Function described as bleeding originating in the retroperitoneal area." + }, + { + "input": "Concept: TSPY-Like Protein 2 (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as testis-specific Y-encoded-like protein 2 (693 aa, ~79 kDa) is encoded by the human TSPYL2 gene. This protein is involved in the assembly of nucleosomes." + }, + { + "input": "Concept: acute; pain (Acute onset pain)", + "output": "Pain, not elsewhere classified described as intensely discomforting, distressful, or agonizing sensation associated with trauma or disease, with well-defined location, character, and timing." + }, + { + "input": "Concept: Anomaly (Finding)", + "output": "Other Finding described as a marked deviation from the normal morphology of a tissue or organ frequently related to congenital defects or disorders. An anomaly may or may not be perceived as a problem condition and may not affect the health status or/and the survival of the animal or species." + }, + { + "input": "Concept: MVA brachyury-TRICOM (rV-Tricom)", + "output": "Immunologic Factor described as a cancer vaccine composed of a replication-deficient, attenuated derivative of the vaccinia virus strain Ankara expressing both a CD8+ T-cell epitope from the brachyury protein and a triad of T-cell co-stimulatory molecules (MVA Brachyury-TRICOM), with potential immunomodulating and antineoplastic activities. Upon subcutaneous administration of the brachyury-expressing modified vaccinia Ankara (MVA)-TRICOM vaccine, the expressed brachyury protein induces specific CD8+ and CD4+ T-cell responses against brachyury-expressing tumor cells. This causes both tumor cell lysis and a decrease in the growth of brachyury-expressing tumor cells. Brachyury, a member of the T-box family of transcription factors that is overexpressed in numerous cancer cell types, is correlated with increased epithelial-mesenchymal transition (EMT), cancer resistance and cancer progression. TRICOM, a triad of three human T-cell co-stimulatory molecules, B7.1, ICAM-1 and LFA-3, enhances antigen-specific T-cell activation." + }, + { + "input": "Concept: Cortex intermedius (Region of cerebral cortex)", + "output": "something described as a cytoarchitecturally defined subdivision of the cerebral cortex that is transitional between neocortex and allocortex ( Mesulam-1984 ). In the terminology of ( Stephan-1975 ) it is a composite of proisocortex, which is a subdivision of neocortex, and periallocortex. See also: paralimbic regions." + }, + { + "input": "Concept: Unilateral Neglect Management (Therapeutic or Preventive Procedure)", + "output": "Procedure with a clinical finding focus described as protecting and safely reintegrating the affected part of the body while helping the patient adapt to disturbed perceptual abilities" + }, + { + "input": "Concept: stachydrine degradation (alpha-amino acid catabolic process)", + "output": "stachydrine metabolic process described as the chemical reactions and pathways resulting in the breakdown of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline." + }, + { + "input": "Concept: microtubule cytoskeleton-dependent nuclear positioning (Cell Function)", + "output": "organelle transport along microtubule described as the directed movement of the nucleus along microtubules within the cell, mediated by motor proteins." + }, + { + "input": "Concept: uV (Unit of electrical potential difference)", + "output": "Unit of electrical potential difference described as a unit of an electric potential and electromotive force equal to one millionth of a volt." + }, + { + "input": "Concept: Associations and organizational services (Associations and organizational services, systems and policies)", + "output": "Occupational Activity described as services and programmes provided by people who have joined together in the pursuit of common, noncommercial interests with people who have the same interests, where the provision of such services may be tied to membership, such as associations and organizations providing recreation and leisure, sporting, cultural, religious and mutual aid services." + }, + { + "input": "Concept: Chest exclusion X-ray (Plain film of body region)", + "output": "Diagnostic radiologic examination described as x ray visualization of the chest and organs of the thoracic cavity; not restricted to visualization of the lungs." + }, + { + "input": "Concept: Meal Data Sponsor-Defined Identifier (Intellectual Product)", + "output": "something described as one or more sponsor defined characters used to identify, name, or characterize the meal data." + }, + { + "input": "Concept: Cervical Verrucous Carcinoma (Verrucous carcinoma)", + "output": "Cervical Squamous Cell Carcinoma described as a highly differentiated variant of cervical squamous cell carcinoma characterized by the presence of a warty surface and stromal invasion with pushing borders. The malignant cells have abundant cytoplasm and minimal nuclear atypia. Koilocytosis is not present." + }, + { + "input": "Concept: Methyl Green Pyronine Staining Method (ObservationMethod - CodeSystem)", + "output": "something described as a histological procedure, which is used for localization of RNA and DNA. Methyl green is a cation, which binds rather specifically to DNA and thus serves as a convenient means of staining nuclei in both fixed material and living cells. Pyronin, a red dye, is fairly specific for RNA with some binding to protein." + }, + { + "input": "Concept: B-Cell CLL/Lymphoma 7A wt Allele (Gene or Genome)", + "output": "Gene or Genome described as human BCL7A wild-type allele is located in the vicinity of 12q24.13 and is approximately 40 kb in length. This allele encodes B-cell CLL/lymphoma 7 family member A protein. Expression of the allele is altered in non-Hodgkin lymphoma patients by a three-way translocation t(8;14;12)(q24.1;q32.3;q24.1) with the MYC gene and the immunoglobulin H locus." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Retrovirus, Human T-Cell Lymphotropic Virus-II, DNA (Medical Device)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Retrovirus, Human T-Cell Lymphotropic Virus-II described as molecular assay reagents intended to identify human T-cell lymphotropic virus, also called human T-cell leukemia/lymphoma virus type II (HTLV-II), by detecting the deoxyribonucleic acid (DNA) of the target viruses. HTLV-II retrovirus is a tumor-producing RNA virus of the subfamily Oncovirinae; it may cause chronic infection, T-cell leukemia, and tropical paraparesis." + }, + { + "input": "Concept: diakinesis (Cell Function)", + "output": "meiosis I cell cycle phase described as the cell cycle phase which follows diplotene during prophase I of meiosis, the separation of homologous chromosomes is complete and crossing over has occurred." + }, + { + "input": "Concept: Health Disparity Research (Health Services Research)", + "output": "Health Services Research described as a multi-disciplinary field of study devoted to gaining greater scientific knowledge about the influence of health determinants, and translating this knowledge into interventions to reduce or eliminate adverse health differences." + }, + { + "input": "Concept: headache disorders (Pain finding at anatomical site)", + "output": "Disease or Syndrome described as various conditions with the symptom of HEADACHE. Headache disorders are classified into major groups, such as PRIMARY HEADACHE DISORDERS (based on characteristics of their headache symptoms) and SECONDARY HEADACHE DISORDERS (based on their etiologies)." + }, + { + "input": "Concept: CMC2 (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as COX assembly mitochondrial protein 2 homolog (79 aa, ~9 kDa) is encoded by the human CMC2 gene. This protein may be involved in localization and assembly of complex IV of the mitochondrial electron transport chain." + }, + { + "input": "Concept: Bleomycin/Dacarbazine/Doxorubicin/Lomustine (Therapeutic or Preventive Procedure)", + "output": "Therapeutic or Preventive Procedure described as a chemotherapy regimen consisting of bleomycin, dacarbazine, doxorubicin and lomustine." + }, + { + "input": "Concept: DefinedProcedure.targetAnatomicSiteLateralityCode (Target Anatomic Site Laterality Code)", + "output": "Target Anatomic Site Laterality Code described as a coded value specifying the side of the body (or a paired organ) that is a target site for a procedure. EXAMPLE(S): bilateral, left, right OTHER NAME(S): NOTE(S): This attribute was deprecated in BRIDG 3.1 but undeprecated in 4.0 since source use cases for separate laterality include SDTM and CTOM. This change ensures that users of the BRIDG model are not bound to a particular kind of vocabulary, such as pre- or post-coordinated vocabularies. Collapsing laterality into the target site code is an implementation option." + }, + { + "input": "Concept: Signal-Transducing Adaptor Protein 1 (Amino Acid, Peptide, or Protein)", + "output": "Biologically Active Substance described as signal-transducing adaptor protein 1 (295 aa, ~34 kDa) is encoded by the human STAP1 gene. This protein is involved in promoting the activity of tyrosine-protein kinase Tec." + }, + { + "input": "Concept: RADIOIMMUNOASSAY, THEOPHYLLINE (Medical Device)", + "output": "Medical Device described as a theophylline test system is a device intended to measure theophylline (a drug used for stimulation of the muscles in the cardiovascular, respiratory, and central nervous systems) in serum and plasma. Measurements obtained by this device are used in the diagnosis and treatment of theophylline overdose or in monitoring levels of theophylline to ensure appropriate therapy." + }, + { + "input": "Concept: Structure of inferior sagittal sinus (Unpaired dural venous sinus)", + "output": "Cranial Sinuses described as unpaired dural sinus, each instance of which is located in the inferior concave border of some falx cerebri; together with the great cerebral vein, forms some straight sinus." + }, + { + "input": "Concept: oncolytic adenovirus ICOVIR5-infected autologous mesenchymal stem cells (Antineoplastic Immune Cell)", + "output": "Cell described as bone marrow-derived autologous mesenchymal stem cells (MSCs) infected with the oncolytic, replication-competent adenovirus ICOVIR5, with potential antineoplastic activity. Upon infusion of the oncolytic adenovirus ICOVIR5-infected autologous MSCs, these cells target the adenovirus to tumors. The oncolytic virus then selectively transfects and replicates in the tumor cells causing a direct cytotoxic effect and lysis of the tumor cells. In addition, the viral infection may stimulate an immune response against the virally-infected tumor cells. This may lead to an inhibition of cancer cell proliferation. ICOVIR-5, a virus derived from wild-type human adenovirus serotype 5 (Had5), has been modified to selectively replicate in tumor cells that have a deregulated retinoblastoma/E2F pathway." + }, + { + "input": "Concept: PRTN3AB (Laboratory Procedure)", + "output": "Measurement of granulocyte antibody described as a measurement of the proteinase 3 antibody in a biological specimen." + }, + { + "input": "Concept: hypoalphalipoproteinemia (LABORATORY ABNORMALITIES)", + "output": "Rare Non-Neoplastic Disorder described as a metabolic disorder characterized by deficiency of high density (alpha) lipoprotein in the blood." + }, + { + "input": "Concept: ACOA (Professional Society)", + "output": "something described as a non-profit association for cancer care administrators in the US. The College focuses on providing educational, funding, peer resources/networking support and opportunity for oncology administrators and managers in all types of healthcare institutions. Publishes Journal of Oncology Management." + }, + { + "input": "Concept: hypertension; newborn (Neonatal cardiovascular disorder)", + "output": "cardiovascular conditions after birth described as abnormally high blood pressure in a newborn child." + }, + { + "input": "Concept: phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase (Molecular Function)", + "output": "something described as catalysis of the reaction: 5-phosphonato-alpha-D-ribose cyclic-1,2-phosphate + H2O <=> D-ribofuranose 2,5-bisphosphate + H+." + }, + { + "input": "Concept: CURVETTE, THERMOSTATED (Medical Device)", + "output": "something described as general purpose laboratory equipment labeled or promoted for a specific medical use is a device that is intended to prepare or examine specimens from the human body and that is labeled or promoted for a specific medical use." + }, + { + "input": "Concept: Submission.receiptDate (Temporal Concept)", + "output": "Receipt Date described as the date (and time) on which the first submission unit is received by the regulatory authority." + }, + { + "input": "Concept: mossy fiber (Cell Component)", + "output": "Cerebellar cortex structure described as nerve fibers branching profusely around cells of the internal layer of the cerebellar cortex." + }, + { + "input": "Concept: VALVE, SWITCHING (Medical Device)", + "output": "something described as a switching valve (ploss) is a three-way valve located between a stethoscope placed over the heart, a blood pressure cuff, and an earpiece. The valve allows the user to eliminate one sound channel and listen only to a patient's heart or korotkoff (blood pressure) sounds through the other channel." + }, + { + "input": "Concept: purine ribonucleoside bisphosphate metabolic process (Genetic Function)", + "output": "Genetic Function described as the chemical reactions and pathways involving a purine ribonucleoside bisphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with one phosphate group attached to each of two different hydroxyl groups on the sugar." + }, + { + "input": "Concept: Acrobrachycephaly (Brachycephaly)", + "output": "Congenital anomaly of bone and joint described as an abnormally high skull with shortness of anterior-posterior dimension. A type of craniosynostosis in which there is premature closure of the coronal suture resulting in an abnormally short anteroposterior diameter of the cranium." + }, + { + "input": "Concept: Clinical Trial Notification to Investigators of Safety Information Document (Intellectual Product)", + "output": "Intellectual Product described as records that describe the notification to investigators of all findings related to the safety of a clinical trial. This may contain important information on serious adverse events and/or safety concerns that could adversely affect the safety of subjects, impact the conduct of the trial, or alter the approval/favorable opinion of the institutional review board (IRB)/independent ethics committee (IEC) to continue the trial." + }, + { + "input": "Concept: CANDF6 (Gene or Genome)", + "output": "something described as human IL17F wild-type allele is located in the vicinity of 6p12 and is approximately 8 kb in length. This allele, which encodes interleukin-17F protein, is involved in cytokine production, cartilage turnover and the regulation of angiogenesis. Mutation of the gene is associated with familial Candidiasis type 6." + }, + { + "input": "Concept: riboflavin reductase (NADH) activity (oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor)", + "output": "oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor described as catalysis of the reaction: reduced riboflavin + NAD+ = riboflavin + NADH + 2 H+." + }, + { + "input": "Concept: Hyperactive tongue (Motor function of tongue - finding)", + "output": "Motor function of tongue - finding described as position and activity of the tongue that can effect the stability and retention of a mandibular complete denture." + }, + { + "input": "Concept: EIM (diagnostic procedure)", + "output": "something described as a non-invasive method of applying and measuring high-frequency, low-intensity electrical currents on the skin over localized muscle or muscle group of interest." + }, + { + "input": "Concept: Reduced ossification of palatine bone (Abnormality of the palatine bone)", + "output": "Defect of skull ossification described as failure to complete ossification (maturation and calcification) of the palatine bone." + }, + { + "input": "Concept: Pharmacokinetic Concentration Date Time (Collection Date Time)", + "output": "Temporal Concept described as the date and time of the pharmacokinetic concentration data." + }, + { + "input": "Concept: Cynodon Rich., 1805 (Eleusininae)", + "output": "Poaceae described as a plant genus of the family POACEAE that is considered a lawn grass by some and a weed by others. It contains allergen Cyn d 7." + }, + { + "input": "Concept: Health and Quality of Life Rating Score 5 (EORTC QLQ-C30 Health and Quality of Life Rating Scale)", + "output": "EORTC QLQ-C30 Health and Quality of Life Rating Scale described as a subjective score of 5 on a scale that ranges from 1: Very Poor to 7: Excellent." + }, + { + "input": "Concept: Hymenolepis nana (Eukaryote)", + "output": "Rodentolepis described as a species of tapeworm in the family Hymenolepididae. The lifecycle of H. nana involves insects as the intermediate host and rodents or humans as the definitive host. Eggs may also be transferred directly from person to person." + }, + { + "input": "Concept: Increased isoleucine diet (Isoleucine modified diet)", + "output": "something described as increase in isoleucine content of the diet compared to the assessed baseline intake of isoleucine for the individual." + }, + { + "input": "Concept: LIM domain kinase 2 (Gene or Genome)", + "output": "something described as this gene is involved in serine/threonine phosphorylation of protein substrates." + }, + { + "input": "Concept: Riluzole (Anticonvulsants)", + "output": "Benzothiazole [EPC] described as a benzothiazole derivative with neuroprotective and potential anti-depressant and anxiolytic activities. While the mechanism of action of riluzole is unknown, its pharmacological activities in motor neurons include the following, some of which may be related to its effect: 1) an inhibitory effect on glutamate release, 2) inactivation of voltage-dependent sodium channels, and 3) interference with intracellular events that follow transmitter binding at excitatory amino acid receptors.In animal models, this agent has been shown to exhibit myorelaxant and sedative activities, apparently due to the blockade of glutamatergic neurotransmission. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47704\" active clinical trials using this agent." + }, + { + "input": "Concept: Aetiology (Disorder Characteristics)", + "output": "Property of Relationship described as the judgment of relatedness between an adverse event and an activity or observation result. EXAMPLE(S): The observation result of \"diabetes\" is assessed to have caused the AE. The activity of administering a concomitant medication is assessed to have caused the AE. The activity of administering the study drug is assessed to have caused the AE." + }, + { + "input": "Concept: Greatest Percentage of Core Involvement by Cancer in Any Core (Finding)", + "output": "Other Finding described as an indication of the percentage of cancerous cells present in the tissue core with the greatest amount of tumor involvement." + }, + { + "input": "Concept: Powder and solvent for epilesional solution (Combined Dosage Form)", + "output": "Combined Dosage Form described as sterile powder and sterile solvent intended for the preparation of an epilesional solution by dissolving the powder in the solvent." + }, + { + "input": "Concept: syndrome; alcohol, fetal (POISON SPECIFIC TERMS)", + "output": "Fetal or neonatal effect of maternal use of alcohol described as a condition occurring in FETUS or NEWBORN due to in utero ETHANOL exposure when mother consumed alcohol during pregnancy. It is characterized by a cluster of irreversible BIRTH DEFECTS including abnormalities in physical, mental, and behavior development (such as FETAL GROWTH RETARDATION; MENTAL RETARDATION; ATTENTION DEFICIT AND DISRUPTIVE BEHAVIOR DISORDERS) with varied degree of severity in an individual." + }, + { + "input": "Concept: trisomy 10 (Anomaly of chromosome pair 10)", + "output": "Anomaly of chromosome pair 10 described as a chromosomal abnormality consisting of the presence of a third copy of chromosome 10 in somatic cells." + }, + { + "input": "Concept: Drug, Cardiotonic (Protective Agents)", + "output": "Agent Affecting Cardiovascular System described as any agent having a favorable effect on the function of the heart." + }, + { + "input": "Concept: interleukin-18 receptor (Interleukin Receptor)", + "output": "Amino Acid, Peptide, or Protein described as cell surface receptors for INTERLEUKIN-18 found on a variety of cell types including MACROPHAGES; NEUTROPHILS; NK CELLS; ENDOTHELIAL CELLS; and SMOOTH MUSCLE CELLS. They are formed as a heterodimer of alpha and beta subunits." + }, + { + "input": "Concept: Erythrocyte inclusion bodies (Abnormality of red blood cells)", + "output": "Abnormality of red blood cells described as nuclear or cytoplasmic aggregates of substances in red blood cells. []" + }, + { + "input": "Concept: AVL01-List A 30 Min Delay Recall Word 5 (Intellectual Product)", + "output": "ADNI-AVLT Questionnaire Question described as auditory Verbal Learning Test Version A - List A, 30 Minute Delay Recall, Word 5." + }, + { + "input": "Concept: Transgenics (Animals, Laboratory)", + "output": "Animals, Laboratory described as experimental organism whose genome has been altered by the transfer of a gene or genes from another species or breed." + }, + { + "input": "Concept: V1B vasopressin receptor binding (Molecular Function)", + "output": "Vasopressin Receptor Binding described as interacting selectively and non-covalently with a V1B vasopressin receptor." + }, + { + "input": "Concept: allergic bites insect reaction (Pathologic Function)", + "output": "Pathologic Function described as hypersensitivity in form of an adverse immune reaction against insect bites. []" + }, + { + "input": "Concept: Radiation Oncology Treatment (Interventional procedure)", + "output": "Radiotherapies site unspecified described as treatment of a disease by means of exposure of the target or the whole body to radiation." + }, + { + "input": "Concept: LYMPHOMA IMMUNOBLASTIC LARGE (Diffuse Large B-Cell Lymphoma)", + "output": "Unspecified and Diffuse Lymphomas described as a malignant neoplasm composed of immunoblasts (large B cells)." + }, + { + "input": "Concept: carbon-oxygen lyase activity (Molecular Function)", + "output": "something described as catalysis of the breakage of a carbon-oxygen bond." + }, + { + "input": "Concept: 065 VETERINARIANS (Health Professional)", + "output": "Animal health occupation described as a doctor of veterinary medicine, trained and authorized to practice veterinarian medicine and surgery." + }, + { + "input": "Concept: Number of Premature Births (Finding)", + "output": "Finding described as a measurement of the total number of birth events at which the gestational age of the neonate is less than 37 weeks and 0 days." + }, + { + "input": "Concept: Hemimandibulectomies (hemi-resection)", + "output": "Excision of bone from facial bones described as surgery to removeone half of the mandible." + }, + { + "input": "Concept: compression (Procedures relating to splintage and immobilization)", + "output": "Procedures relating to splintage and immobilization described as the use of compression dressings or garments to prevent or treat any of various conditions." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Serology, Parasite, Babesia Species, Antibody (IVD Test Reagent/Kits, Serology, Parasite)", + "output": "something described as serology reagents used to detect antibodies to species of Babesia, a hematozoan protozoon. Several species of these parasites may cause babesiosis (piroplasmosis), a disease characterized by malaria-like fever, chills, sweats, and myalgia." + }, + { + "input": "Concept: Thiazolidinedione Antidiabetic Agent (Pharmacologic Substance)", + "output": "Antidiabetics described as any antidiabetic agent with the glitazone (thiazolidinedione) base structure with antihyperglycemic activity. Glitazone antidiabetic agents selectively bind to and stimulate the nuclear receptor peroxisome proliferator-activated receptor (PPAR) gamma. This results in the selective transcription of a number of insulin-sensitive genes involved in glucose metabolism. This eventually enhances insulin sensitivity, reduces insulin resistance and decreases hepatic gluconeogenesis. PPARs function as transcription factors that regulate expressions of genes involved in cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), as well as tumorigenesis; PPARgamma is expressed at high levels in adipose tissue." + }, + { + "input": "Concept: alpha-beta T-cell lineage commitment (Cell Function)", + "output": "T cell lineage commitment described as the process in which a pro-T cell becomes committed to becoming an alpha-beta T cell." + }, + { + "input": "Concept: TAP2 binding (Molecular Function)", + "output": "something described as interacting selectively and non-covalently with the TAP2 subunit of TAP (transporter associated with antigen processing) protein." + }, + { + "input": "Concept: Regimen Used to Treat Malignant Reproductive Endocrine Neoplasm (Chemo/immuno/hormone Therapy Regimen)", + "output": "Therapeutic or Preventive Procedure described as any regimen that can be used to treat malignant reproductive endocrine neoplasm." + }, + { + "input": "Concept: Bothered by Tension (Intellectual Product)", + "output": "Clinical or Research Assessment Question described as a question about whether an individual is or was bothered by tension." + }, + { + "input": "Concept: carbon C 11 PBR-28 (Organic Chemical)", + "output": "Radioconjugate described as a radioconjugate composed of a ligand for the 18 kDa translocator protein (TSPO) conjugated to the radioisotope carbon C 11, that can be used as a diagnostic imaging agent to detect TSPO-expressing cells using positron emission tomography (PET). Upon administration of carbon C 11 PBR-28, the PBR-28 moiety targets and binds to TSPO-expressing cells. Upon PET, carbon C 11 can be detected and TSPO-expressing cells can be visualized. This can facilitate detection of inflammatory sites and cancer cells. TSPO, also called the peripheral benzodiazepine receptor (PBR), is found on the outer mitochondrial membrane and is overexpressed on a variety of cancer cells and during inflammation." + }, + { + "input": "Concept: MSK (Qualitative Concept)", + "output": "Missing Value Reason described as information exists but is not provided due to security or privacy concerns." + }, + { + "input": "Concept: Retinopathy, Pericentral Pigmentary, Autosomal Recessive (Disease or Syndrome)", + "output": "Disease or Syndrome described as a subtype of retinitis pigmentosa in which, instead of the pathology starting in the mid-periphery like typical retinitis pigmentosa, the disease starts in the near periphery closer to the vascular arcades and tends to spare the far periphery." + }, + { + "input": "Concept: Adducted thumbs and arthrogryposis syndrome Christian type (Amyoplasia congenita disruptive sequence)", + "output": "Disease or Syndrome described as a type of arthrogryposis with characteristics of congenital cleft palate, microcephaly, craniostenosis and arthrogryposis. Additional features include facial dysmorphism. Velopharyngeal insufficiency with difficulties in swallowing, increased secretion of the nose and throat, prominent occiput, generalized muscular hypotonia with mild cyanosis and no spontaneous movements, seizures, torticollis, areflexia, intellectual disability, hypertrichosis of the lower extremities, and scleredema are also observed. The disease often leads to early death. Transmission is autosomal recessive. No new cases have been described since 1983." + }, + { + "input": "Concept: Preconception (Pregnancy Status)", + "output": "Clinical Attribute described as the time period prior to conception." + }, + { + "input": "Concept: BODE01-Body-mass Index (BODE Index Clinical Classification Question)", + "output": "something described as the Body-Mass Index, Airflow Obstruction, Dyspnea, and Exercise Capacity Index (BODE Index) Body-mass index." + }, + { + "input": "Concept: Laryngeal Cancer Clinical TNM Finding v8 (Laryngeal Cancer TNM Finding v8)", + "output": "Finding described as a clinical finding about one or more characteristics of laryngeal cancer, following the rules of the TNM AJCC v8 classification system." + }, + { + "input": "Concept: cellular response to aldehyde (Cell Function)", + "output": "response to organic substance described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldehyde stimulus." + }, + { + "input": "Concept: BATABULIN SODIUM (Pharmacologic Substance)", + "output": "Colchicine-Site Binding Agent described as the sodium salt form of batabulin, a synthetic pentafluorophenylsulfonamide with potential antineoplastic activity. Batabulin covalently binds to and selectively modifies the beta 1, beta 2, beta 3, and beta 4 isotypes of beta tubulin at a conserved cysteine residue, resulting in disruption of microtubule polymerization, collapse of the cytoskeleton, an increase in chromosomal ploidy, cell cycle arrest, and tumor cell apoptosis." + }, + { + "input": "Concept: Engaged in boxing (Contact sport)", + "output": "Sports described as a two-person sport in which the fists are skillfully used to attack and defend." + }, + { + "input": "Concept: bHLHe35 (Biologically Active Substance)", + "output": "something described as transcription factor EB (476 aa, ~53 kDa) is encoded by the human TFEB gene. This protein plays a role in transcriptional regulation." + }, + { + "input": "Concept: Muscle of Riolan (Superficial Abdominal Muscle)", + "output": "Skeletal muscle structure of inguinal region described as a thin skeletal muscle enveloping the testis and the spermatic cord, which originates from the internal oblique and inguinal ligament, inserts into the cremasteric fascia and pubic tubercle, and functions to raise and lower the testes." + }, + { + "input": "Concept: regulation of plasmatocyte differentiation (Cell Function)", + "output": "something described as any process that modulates the frequency, rate or extent of plasmatocyte differentiation." + }, + { + "input": "Concept: ambazone (Antineoplastic Agents)", + "output": "Antiseptic throat preparations described as an antiseptic agent with potential antibacterial and antileukemic activity. Although the exact mechanism of action remains to be fully elucidated, ambazone appears to interfere with the membrane-bound nucleotide system by increasing the intracellular concentration of cAMP in leukemia cells and macrophages, which potentially contributes to this agent's antineoplastic activity. Furthermore, this agent's affinity for various cellular targets, i.e. membranes, nucleic acids and proteins, may contribute to the overall antibacterial effect." + }, + { + "input": "Concept: Mucosal Vascular Addressin Cell Adhesion Molecule 1 wt Allele (Gene or Genome)", + "output": "something described as human MADCAM1 wild-type allele is located in the vicinity of 19p13.3 and is approximately 16 kb in length. This allele, which encodes mucosal addressin cell adhesion molecule 1 protein, is involved in lymphocyte trafficking." + }, + { + "input": "Concept: Peptide Bond Constituents (Chemical Viewed Structurally)", + "output": "something described as the amine group and carboxyl group found in adjacent amino acids that form a peptide bond." + }, + { + "input": "Concept: Todaro tendon (Right atrial structure)", + "output": "Tendon structure described as tenson, each instance of which is a subendocardial collagen bundle in the wall of some right atrium, extending from some central fibrous body across some torus aorticus toward the medial extremity of the valve of some inferior vena cava." + }, + { + "input": "Concept: CT of chest without contrast (CT without contrast)", + "output": "something described as computed tomography of the chest without the use of a contrast agent." + }, + { + "input": "Concept: upregulation of nitric-oxide synthase activity (positive regulation of monooxygenase activity)", + "output": "something described as any process that activates or increases the activity of the enzyme nitric-oxide synthase." + }, + { + "input": "Concept: ribonucleic transcriptase activity (Molecular Function)", + "output": "something described as catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 3'-end." + }, + { + "input": "Concept: Distractors, Surgical, Shoulder (Distractors, Surgical)", + "output": "Distractors, Surgical described as surgical distractors designed to apply traction force to the arm allowing access to the shoulder joint space. The distractors allow the surgeon to adjust the angle of abduction and the forward flexion angle. These distractors typically consist of an adjustable force mechanism that may include clamps, screws, levers, and a strap attached to the arm; the mechanism may be attached to the operating table (e.g., on a side rail) or other type of support. Shoulder distractors are intended for use during shoulder (and/or elbow) surgical procedures, such as arthroscopic surgery." + }, + { + "input": "Concept: glutamine binding (amino acid binding)", + "output": "cation binding described as interacting selectively and non-covalently with glutamine, 2,5-diamino-5-oxopentanoic acid." + }, + { + "input": "Concept: Mantle Field (Body Location or Region)", + "output": "Radiation Field described as the area of the neck, chest, and lymph nodes in the armpit that are exposed to radiation." + }, + { + "input": "Concept: MAXIMUM (Quantitative Concept)", + "output": "Quantitative Concept described as a data derivation technique used to calculate a subject's maximum value over a defined set of records." + }, + { + "input": "Concept: Calprotectin Measurement (Laboratory Procedure)", + "output": "Laboratory Procedure described as the determination of the amount of calprotectin present in a sample." + }, + { + "input": "Concept: neoplasm with perivascular epithelioid cell differentiation (Neoplastic Process)", + "output": "Soft Tissue Tumor of Uncertain Differentiation described as a soft tissue mesenchymal tumor with perivascular epithelioid cell differentiation. Representative examples include angiomyolipoma, clear cell-sugar-tumor of the lung, and lymphangioleiomyomatosis." + }, + { + "input": "Concept: Pathology, Speech-Language (Allied Health Occupations)", + "output": "Allied Health Occupations described as the study of speech or language disorders and their diagnosis and correction." + }, + { + "input": "Concept: HCS (Gene or Genome)", + "output": "something described as human CYCS wild-type allele is located in the vicinity of 7p15.3 and is approximately 7 kb in length. This allele, which encodes cytochrome c protein, plays a role in the mitochondrial electron transport chain. Mutation of the gene is associated with thrombocytopenia 4." + }, + { + "input": "Concept: Gastric Cancer pTX TNM Finding (Gastric Cancer Pathologic Primary Tumor TNM Finding v7)", + "output": "Gastric Cancer Pathologic Primary Tumor TNM Finding v7 described as gastric cancer in which the primary tumor cannot be assessed." + }, + { + "input": "Concept: Unknown History of Alcohol Use (Finding)", + "output": "Finding described as an indication that it is unknown whether the patient has a history of alcohol use." + }, + { + "input": "Concept: preprophase band assembly (cell cycle process)", + "output": "cellular component assembly described as the aggregation, arrangement and bonding together of a set of components to form the preprophase band, a dense band of microtubules that marks the position in the cell where cytokinesis will occur in cells that perform cytokinesis by cell plate formation." + }, + { + "input": "Concept: Intact Fibroblast Growth Factor 23 Measurement (Protein or Enzyme Type Measurement)", + "output": "Protein or Enzyme Type Measurement described as a measurement of the intact fibroblast growth factor 23 in a biological specimen." + }, + { + "input": "Concept: Pharmacokinetics (Pharmacological and Toxicological Phenomena)", + "output": "something described as dynamic and kinetic mechanisms of exogenous chemical DRUG LIBERATION; ABSORPTION; BIOLOGICAL TRANSPORT; TISSUE DISTRIBUTION; BIOTRANSFORMATION; elimination; and DRUG TOXICITY as a function of dosage, and rate of METABOLISM. LADMER, ADME and ADMET are abbreviations for liberation, absorption, distribution, metabolism, elimination, and toxicology." + }, + { + "input": "Concept: Mitosis Inhibitor T 1101 Tosylate (Antimitotic Agents)", + "output": "Pharmacologic Substance described as the tosylate salt form of T-1101, an inhibitor of mitosis, with potential antineoplastic activity. Upon oral administration, T-1101 inhibits mitosis, through an as of yet not elucidated mechanism of action, which leads to decreased tumor cell proliferation." + }, + { + "input": "Concept: Opossums (Subfamily Didelphinae)", + "output": "Subfamily Didelphinae described as a genus of large OPOSSUMS in the family Didelphidae, found in the Americas. The species Didelphis virginiana is prominent in North America." + }, + { + "input": "Concept: deviationCategoryCode (Intellectual Product)", + "output": "Intellectual Product described as a coded value specifying a classification of a deviation." + }, + { + "input": "Concept: FACT-An (Clinical or Research Assessment Questionnaire)", + "output": "Intellectual Product described as a subscale complement to the FACT-G developed specifically for evaluating the quality of life of cancer patients with anemia and fatigue." + }, + { + "input": "Concept: Grade 4 Burn, CTCAE (Burn, CTCAE)", + "output": "Burn, CTCAE described as life-threatening consequences" + }, + { + "input": "Concept: HCV Genotype Finding (Laboratory test finding)", + "output": "something described as the determination of the genotype of hepatitis c virus in a blood sample." + }, + { + "input": "Concept: Intercostal space (Sign or Symptom)", + "output": "Chest Pain described as the location of the chest pain is in the area defined by a superior rib margin and an inferior rib margin." + }, + { + "input": "Concept: MENINGOENCEPHALITIS (Non-Neoplastic Central Nervous System Disorder)", + "output": "Central Nervous System Viral Diseases described as inflammation of the meninges and brain, generally secondary to an infectious cause. Pathogens may be bacterial, viral, fungal, or protozoan." + }, + { + "input": "Concept: obstruction; gastric outlet (Stomach Diseases)", + "output": "Disease or Syndrome described as the hindering of output from the STOMACH into the SMALL INTESTINE. This obstruction may be of mechanical or functional origin such as EDEMA from PEPTIC ULCER; NEOPLASMS; FOREIGN BODIES; or AGING." + }, + { + "input": "Concept: epicardium-derived cardiac endothelial cell differentiation (Cell Function)", + "output": "cardiac endothelial cell differentiation described as the process in which an epicardial cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." + }, + { + "input": "Concept: Chlorthiazide (Diuretics)", + "output": "Organic Chemical described as a thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE." + }, + { + "input": "Concept: West virginia (US State)", + "output": "Appalachian Region described as a state in the mid-atlantic United States. Its capital is Charleston." + }, + { + "input": "Concept: Complete duplication of the outermost bone of the ring finger (Complete duplication of the phalanges of the 4th finger)", + "output": "Anatomical Abnormality described as complete duplication of the distal phalanx of ring finger." + }, + { + "input": "Concept: Macrophages, Peritoneal (macrophage)", + "output": "macrophage described as a differentiated macrophage that resides in the serosal peritoneal membrane and plays an important role in the defense against peritoneal cavity infections." + }, + { + "input": "Concept: Wall of synovial tendon sheath of ring finger (Wall of synovial tendon sheath of finger)", + "output": "something described as wall of synovial tendon sheath of ring finger" + }, + { + "input": "Concept: CFHL1 (Gene or Genome)", + "output": "Complement Component Gene described as this gene plays a role in complement regulation." + }, + { + "input": "Concept: Ion, NOS (General chemical forms)", + "output": "Chemicals described as an atom or group of atoms that have a positive or negative electric charge due to a gain (negative charge) or loss (positive charge) of one or more electrons. Atoms with a positive charge are known as CATIONS; those with a negative charge are ANIONS." + }, + { + "input": "Concept: RADIOLOGICAL/NUCLEAR (Challenge Agent)", + "output": "Challenge Agent described as a challenge agent that emits ionizing radiation." + }, + { + "input": "Concept: Minor finding (Intellectual Product)", + "output": "something described as in clinical parlance, findings are occasionally interpreted as being distinctive or minor, reflecting a subjective clinical impression of the importance of a feature for the differential diagnosis. A minor finding is taken to be one that is unlikely to help distinguish the correct diagnosis from other candidates in the differential. []" + }, + { + "input": "Concept: Fulvestrant Regimen (Therapeutic or Preventive Procedure)", + "output": "something described as a hormone therapy regimen consisting of fulvestrant that may be used in the treatment of advanced breast cancer." + }, + { + "input": "Concept: Nucleus Interpeduncularis (raphe nuclei)", + "output": "Body Part, Organ, or Organ Component described as a group of cells located at the midline of the ventral midbrain tegmentum ( Carpenter-1983 ). More homogeneous in the primate than in the rodent, it is variably subdivided by different authors in the different species. In the human it is divided into four subnuclei: rostral subnucleus of the interpeduncular nucleus, apical subnucleus of the interpeduncular nucleus, dorsal part of the lateral subnucleus of the interpeduncular nucleus, and caudal subnucleus of the interpeduncular nucleus ( Paxinos-2012 ), The macaque has three subnuclei: rostral and caudal subnuclei as in the human and a lateral subnucleus of the interpeduncular nucleus ( Paxinos-2009a ). \\r\\nIn the rat ( Swanson-2004; Paxinos-2009b ) and the mouse ( Franklin-2008 ) all authors identify five subnuclei: rostral subnucleus of the interpeduncular nucleus, apical subnucleus of the interpeduncular nucleus, lateral subnucleus of the interpeduncular nucleus, dorsal part of the lateral subnucleus of the interpeduncular nucleus, and intermediate subnucleus of the interpeduncular nucleus; they differ with regard to the presence or absence of three other subnuclei. Functionally the interpeduncular nucleus belongs to the behavioral state system ( Swanson-2004 )." + }, + { + "input": "Concept: FIP-1 (RRAGA gene)", + "output": "Gene or Genome described as human RRAGA wild-type allele is located in the vicinity of 9p22.1 and is approximately 2 kb in length. This allele, which encodes Ras-related GTP-binding protein A, may be involved in the progression of tumor necrosis factor-alpha signaling." + }, + { + "input": "Concept: colony-form units/milliliter (Unit of Arbitrary Substance Concentration)", + "output": "Unit of microbial assay described as a unit of measurement of viable bacterial organisms in a unit volume of substance of interest defined as the number of colony forming units in one milliliter of substance." + }, + { + "input": "Concept: hemophilia disorder (Coagulation factor deficiency syndrome)", + "output": "something described as a rare, hereditary blood disorder marked by a tendency toward excessive bleeding" + }, + { + "input": "Concept: IVD Test Reagent/Kits, Immunocytochemistry/Immunohistochemistry, Tumor Marker, ER (IVD Test Reagent/Kits, Immunocytochemistry/Immunohistochemistry, Tumor Marker)", + "output": "Medical Device described as immunocytochemistry reagents intended to perform qualitative and/or quantitative analyses on tissue preparations to determine a cellular regulatory protein that binds estrogenic hormones (i.e., cytoplasmic estrogen receptors). These receptors are especially found in estrogen-sensitive tissues (e.g., breast and uterus tissues). The assays are performed in surgically removed samples. Determination of the level of estrogen receptors is used as a marker of the response to endocrine therapy in diseases such as breast carcinoma." + }, + { + "input": "Concept: RFTDTC (Date/Time)", + "output": "Date/Time described as the date and time of a specific reference point." + }, + { + "input": "Concept: Abnormal platelet phosphatidylserine exposure (Finding)", + "output": "something described as an abnormality of phosphatidylserine (PS) on activated platelets. PS is normally located on the cytoplasmic face of the resting platelet membrane but appears on the plasma-oriented surface of discrete membrane vesicles that derive from activated platelets. Thrombin, the central molecule of coagulation, is produced from prothrombin by a complex (prothrombinase) between factor Xa and its protein cofactor (factor V(a)) that forms on platelet-derived membranes. This complex enhances the rate of activation of prothrombin to thrombin by roughly 150,000 fold relative to factor X(a) in solution. The negatively charged surface of PS-containing platelet-derived membranes is at least partly responsible for this rate enhancement." + }, + { + "input": "Concept: Dental Implant Loading, Immediate (Therapeutic or Preventive Procedure)", + "output": "something described as endosseous dental implantation where implants are fitted with an abutment or where an implant with a transmucosal coronal portion is used immediately (within 1 week) after the initial extraction. Conventionally, the implantation is performed in two stages with more than two months in between the stages." + }, + { + "input": "Concept: RAND-36 - Felt Nothing Could Cheer You Up (Intellectual Product)", + "output": "something described as RAND 36-Item Health Survey 1.0 (RAND-36) How much of the time during the past 4 weeks: Have you felt so down in the dumps that nothing could cheer you up?" + }, + { + "input": "Concept: Congenital meningocele (Central nervous system disorders congenital NEC)", + "output": "Congenital connective tissue disorder described as a congenital abnormality in which the meninges protrude through a defect in the spinal column or the cranium." + }, + { + "input": "Concept: Oximeters, Intravascular (Oxygen analyzer, device)", + "output": "Oxygen analyzer, device described as oximeters that measure the mixed venous blood-oxygen saturation (SvO2) using a catheter that includes optical fibers. These oximeters include LED light sources, which generate light of different wavelengths and are transmitted through a fiberoptic channel to the tip of the catheter, where they are absorbed, refracted, and reflected by the red blood cells. The blood reflectance changes, which depend on hemoglobin forms, are processed and displayed as SvO2 values. These oximeters are used in diagnostic cardiac catheterization, cardiac surgery, and sometimes to evaluate SvO2 in newborns through an umbilical artery. Some instruments may be coupled with dedicated pulmonary arterial catheters to perform the continuous display of both SvO2) and hemodynamic measurements." + }, + { + "input": "Concept: N-Terminal Acetyltransferase B (Enzyme)", + "output": "Enzyme described as an N-terminal acetyltransferase subtype that consists of the Naa20p catalytic subunit and the Naa25p auxiliary subunit. The structure of this enzyme is conserved between YEASTS and HUMAN. It has specificity for the N-terminal METHIONINE of peptides where the next amino acid in the chain is either ASPARTATE; GLUTAMATE; ASPARAGINE; or GLUTAMINE." + }, + { + "input": "Concept: Renal Pelvis and Ureter Cancer by AJCC v7 Stage (Renal Pelvis and Ureter Urothelial Carcinoma)", + "output": "something described as a term that refers to the staging of renal pelvis and ureter cancer according to the American Joint Committee on Cancer, 7th edition." + }, + { + "input": "Concept: carbohydrate utilization (Cell Function)", + "output": "Biological Processes described as a series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbohydrate sources,usually glucose, and then activates genes to scavenge the last traces of the primary carbohydrate source and to transport and metabolize alternate carbohydrate sources. The utilization process begins when the cell or organism detects carbohydrate levels, includes the activation of genes whose products detect, transport or metabolize carbohydrates, and ends when the carbohydrate is incorporated into the cell or organism's metabolism." + }, + { + "input": "Concept: down-regulation of immunoglobulin mediated immune response (Organism Function)", + "output": "Organism Function described as any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response." + }, + { + "input": "Concept: 3alpha-hydroxy-ent-sandaracopimardiene 7-beta-monooxygenase activity (Molecular Function)", + "output": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen described as catalysis of the reaction: ent-sandaracopimaradien-3-beta-ol + NADPH + H+ + O2 <=> oryzalexin D + NADP + H2O." + }, + { + "input": "Concept: regulation of interleukin-27 production (Organism Function)", + "output": "Organism Function described as any process that modulates the frequency, rate, or extent of interleukin-27 production." + }, + { + "input": "Concept: PEXASTIMOGENE DEVACIREPVEC (Pharmacologic Substance)", + "output": "Gene Therapy Agent described as a thymidine kinase-deleted vaccinia virus expressing human GM-CSF (hGM-CSF) with oncolytic activity. Upon intratumoral or intravenous administration, pexastimogene-devacirepvec may selectively infect and lyse tumor cells. While vaccinia displays a natural tumor cell tropism, deletion of the thymidine kinase gene increases the tumor selectivity of vaccinia by limiting viral replication to transformed cells. hGM-CSF expression by this agent may help recruit antigen processing cells (APCs), such as denritic cells and macrophages, to virally infected tumor cells, initiating a systemic antitumoral immune response. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C71533\" active clinical trials using this agent." + }, + { + "input": "Concept: Hageman factor activation (Molecular Function)", + "output": "something described as any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade." + }, + { + "input": "Concept: Performed Study Subject Milestone Registration Date (Study Registration Date)", + "output": "something described as the date (and time) the subject has been registered to the study assuming they have finished screening and have been found eligible. NOTE(S): Derived from PerformedActivity.PerformedAdministrativeActivity. PerformedStudySubjectMilestone.actualDateRange WHERE PerformedActivity DefinedActivity.nameCode = \"register subject\"." + }, + { + "input": "Concept: congenital blood protein disorder (congenital blood disorder)", + "output": "congenital blood disorder described as blood protein disorders that exist at, and usually before, birth regardless of their causation; blood proteins include but not limited to serum albumin, blood coagulation factors and plasma proteins." + }, + { + "input": "Concept: Membranous Insertion (Umbilical cord complication during labor and delivery)", + "output": "Anomaly of placenta described as insertion of the umbilical cord into the chorio-amniotic membranes of the placenta." + }, + { + "input": "Concept: corneal grafting (Surgical ocular refractive procedure)", + "output": "Ophthalmologic Surgical Procedures described as plastic surgery of the cornea; partial or total replacement of the cornea." + }, + { + "input": "Concept: dialysis catheter; embolism (Pathologic Function)", + "output": "Embolism described as an obstruction of a vessel caused by a detached fragment of an indwelling dialysis catheter." + }, + { + "input": "Concept: left eye (HumanSubstanceAdministrationSite)", + "output": "Orbital region described as the eye positioned in the left orbit, Oculus Sinister." + }, + { + "input": "Concept: OPTI-Surg Pre-Surgical Frailty Assessment with Resource Recommendations (Intellectual Product)", + "output": "Intellectual Product described as a set of pre-surgical questionnaires, including a frailty assessment, designed to provide resource-customized recommendations to address identified vulnerabilities in individual patients." + }, + { + "input": "Concept: Extremophiles (Organism Forms)", + "output": "Organism described as organisms specifically adapted to live in EXTREME ENVIRONMENTS." + }, + { + "input": "Concept: CD10 (Cell Count)", + "output": "something described as a measurement of the CD10 expressing cells per unit in a biological specimen." + }, + { + "input": "Concept: In Situ Hybridization Shared Resource (Clinical or Research Facility)", + "output": "something described as the In Situ Hybridization Shared Resource provides Cancer Center investigators with histological review and interpretation of immunohistochemical and in situ hybridization studies of human and experimental animal solid tumor specimens." + }, + { + "input": "Concept: Assessment of Fetal Heart Condition (Fetal Examination)", + "output": "something described as the monitoring of the fetal heart to determine the cardiac status and health of the fetus during pregnancy and labor." + }, + { + "input": "Concept: Protein Carbonylations (Post-Translational Protein Processing)", + "output": "Post-Translational Protein Processing described as the appearance of carbonyl groups (such as aldehyde or ketone groups) in PROTEINS as the result of several oxidative modification reactions. It is a standard marker for OXIDATIVE STRESS. Carbonylated proteins tend to be more hydrophobic and resistant to proteolysis." + }, + { + "input": "Concept: AGRICULTURAL WORKER DIS (Occupational Diseases)", + "output": "something described as diseases in persons engaged in cultivating and tilling soil, growing plants, harvesting crops, raising livestock, or otherwise engaged in husbandry and farming. The diseases are not restricted to farmers in the sense of those who perform conventional farm chores: the heading applies also to those engaged in the individual activities named above, as in those only gathering harvest or in those only dusting crops." + }, + { + "input": "Concept: MYCEPIDX (Laboratory Procedure)", + "output": "something described as a relative measurement (ratio) of the sum of myeloid proliferative phase cells (pool) to the sum of myeloid maturation phase cells (pool) in a biological specimen." + }, + { + "input": "Concept: ALLIED HEALTH OCCUP (Biomedical Occupation or Discipline)", + "output": "Biomedical Occupation or Discipline described as occupations of medical personnel who are not physicians, and are qualified by special training and, frequently, by licensure to work in supporting roles in the health care field. These occupations include, but are not limited to, medical technology, physical therapy, physician assistant, etc." + }, + { + "input": "Concept: Clinical Trial Indemnity Document (Intellectual Product)", + "output": "something described as records certifying legal protection in the event of any unforeseen adverse circumstance arising during the course of a clinical trial." + }, + { + "input": "Concept: MIRN30C1 (Gene or Genome)", + "output": "something described as human MIR30C1 wild-type allele is located in the vicinity of 1p34.2 and is approximately 89 bases in length. This allele, which encodes MIR30C1 pre-miRNA, plays a role in the modulation of gene expression." + }, + { + "input": "Concept: Gel (Basic Dosage Form Category)", + "output": "something described as a type of semi-solid pharmaceutical dose form consisting of a colloidal dispersion of a liquid in a solid; lipophilic gels (oleogels) usually consist of liquid paraffin with polyethylene or fatty oils gelled with colloidal silica or aluminium or zinc soaps; hydrophilic gels (hydrogels) usually consists of water, glycerol or propylene glycol gelled with suitable gelling agents such as poloxamers, starch, cellulose derivatives, carbomers and magnesium-aluminium silicates." + }, + { + "input": "Concept: Vascular closure device (Device Labeled for Single Use)", + "output": "Surgical Fixation Devices described as products used to seal the openings in BLOOD VESSELS from incisions or punctures made during ENDOVASCULAR PROCEDURES." + }, + { + "input": "Concept: 1p/19q Deletion Analysis Testing Method (Intellectual Product)", + "output": "Specify Molecular Abnormality Analysis Method described as a request to enter the specific molecular analysis method used to determine the 1q/19q deletion status." + }, + { + "input": "Concept: zetta (Metric Prefix)", + "output": "something described as a prefix indicating a quantity of one sextillion, 10E21." + }, + { + "input": "Concept: 1-hydroxy-2-naphthoate dioxygenase activity (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)", + "output": "Molecular Function described as catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 = (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate." + }, + { + "input": "Concept: SGPL1 (Lyase Gene)", + "output": "Gene or Genome described as this gene plays a role in the metabolism of phosphorylated sphingoid bases." + }, + { + "input": "Concept: GRAN F/SUS (Biomedical or Dental Material)", + "output": "Biomedical or Dental Material described as a small medicinal particle or grain made available in its more stable dry form, to be reconstituted with solvent just before dispensing to form a suspension; the granules are so prepared to contain not only the medicinal agent, but the colorants, flavorants, and any other desired pharmaceutic ingredient." + }, + { + "input": "Concept: PUQUITINIB MESYLATE (Organic Chemical)", + "output": "something described as the mesylate salt of puquitinib, an orally available selective inhibitor of the delta form of phosphatidylinositol 3-kinase (PI3-kinase subunit delta; PI3K-delta; PI3Kdelta), with potential antineoplastic activity. Upon oral administration, puquitinib selectively binds to the ATP-binding pocket of PI3K-delta and prevents the activation of the PI3K/AKT signaling pathway. This decreases proliferation of and induces cell death in PI3K-delta over-expressing tumor cells. PI3K-delta also plays a key role in the B-cell receptor (BCR) signaling pathway and the proliferation of certain hematologic cancer cells. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells, thereby minimizing serious side effects." + }, + { + "input": "Concept: Electrolyte Replacement Agent (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as any agent or mixture of agents that are used to replenish electrolytes in body fluids, such as sodium, potassium, calcium, magnesium, phosphorus, chloride and bicarbonate." + }, + { + "input": "Concept: SPCA2 (Gene or Genome)", + "output": "ATP2C2 gene described as human ATP2C2 wild-type allele is located in the vicinity of 16q24.1 and is approximately 96 kb in length. This allele, which encodes calcium-transporting ATPase type 2C member 2 protein, is involved in the modulation of both ATP hydrolysis and calcium transport. Genetic polymorphism may be associated with breast cancer." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Immunohematology, Control, Coombs Cell (Medical Device)", + "output": "IVD Test Reagent/Kits, Immunohematology, Control described as control reagents that consist of immunoglobuli-G-coated cells that are added after negative antiglobulin tests to provide verification that the antiglobulin reagent (i.e., antihuman globulin) was functional." + }, + { + "input": "Concept: CREAM (Biomedical or Dental Material)", + "output": "Cutaneous AND/OR transdermal dosage form described as a semisolid emulsion of either the oil-in-water or the water-in-oil type, ordinarily intended for topical use." + }, + { + "input": "Concept: Recombinant Interleukin-16 (Pharmacologic Substance)", + "output": "Pharmacologic Substance described as a recombinant chemokine of human lymphotactin which is produced by activated progenitor T cells and characterized by specific chemotactic activity for lymphocytes." + }, + { + "input": "Concept: PRESEQUENCE PROTEASE (Gene or Genome)", + "output": "something described as this gene is involved in mitochondrial peptide degradation." + }, + { + "input": "Concept: metanephric capsule formation (renal capsule formation)", + "output": "something described as the developmental process pertaining to the initial formation of a metanephric capsule from unspecified parts. The metanephric capsule is the tough fibrous layer surrounding the metanephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage." + }, + { + "input": "Concept: FAC01741 (Intellectual Product)", + "output": "FACT-LEU Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Leukemia Version 4 - Additional Concerns: I feel uncertain about my future health." + }, + { + "input": "Concept: FACIT-Dyspnea Scale 33 Item Bank Version - Limit: Carrying Less Than 5 Lbs (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)", + "output": "FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question described as functional Assessment of Chronic Illness Therapy-Dyspnea Scale 33 Item Bank (FACIT-Dyspnea Scale 33 Item Bank Version) Functional Limitation: Considering your shortness of breath over the past 7 days, rate the amount of difficulty you had when doing the following activities: Carrying something weighing less than 5 lbs (about 2 kg, like a houseplant) from one room to another." + }, + { + "input": "Concept: Nucleus corporis trapezoidei anterior (Structure of superior olivary nucleus)", + "output": "Trapezoid body nucleus described as a group of nerve cells in the pontine tegmentum ( Nomina-1983 )." + }, + { + "input": "Concept: Optoisolator (Device Component or Accessory)", + "output": "Device Component or Accessory described as an electronic device designed to convert an electrical signal to an optical one or an optical signal to an electrical one, especially as part of a system to optically link circuits that are electrically isolated." + }, + { + "input": "Concept: Order Clostridiales (Class Clostridia)", + "output": "Class Clostridia described as an order of anaerobic bacteria that are predominantly GRAM POSITIVE within the phylum Firmicutes. It includes the Clostridium and Eubacterium genera." + }, + { + "input": "Concept: 2q36 (Chromosome band)", + "output": "Chromosome band described as a chromosome band present on 2q" + }, + { + "input": "Concept: papillary serous adenocarcinoma (Micropapillary carcinoma)", + "output": "Micropapillary carcinoma described as an adenocarcinoma usually arising from the ovary. It is characterized by the presence of complex micropapillary structures covered by round and cuboidal cells with a high nuclear to cytoplasmic ratio." + }, + { + "input": "Concept: Clarity Measurement (Chemical procedure)", + "output": "something described as the determination of the transparency of a sample." + }, + { + "input": "Concept: Photon Radiation Detectors, Radiotherapy (Medical Device)", + "output": "Detectors described as photon radiation detectors designed for sensing the position of photon beams used in radiotherapy treatments. These detectors typically consist of a stand-alone or handheld instrument, controls, and a display that shows an image with the position of the photon radiation beam. Some detectors are based on a technology that includes a gaseous detector with metal converters and gas electron multipliers (GEMs); detectors based on amorphous silicon technology (i.e., electronic portal imaging devices/EPIDs) are also available. Radiotherapy photon radiation detectors are intended for use in complex radiotherapy treatments (e.g., cone beam computed tomography radiotherapy) to improve the positioning and accurate delivery of photon radiation; they may be also used in conventional x-ray treatments." + }, + { + "input": "Concept: CD183 ANTIGEN (Gene or Genome)", + "output": "something described as this gene plays a role in immune cell chemotaxis and trafficking." + }, + { + "input": "Concept: PANELS, TEST, SUSCEPTIBILITY, ANTIMICROBIAL (Medical Device)", + "output": "Medical Device described as an antimicrobial susceptibility test powder is a device that consists of an antimicrobial drug powder packaged in vials in specified amounts and intended for use in clinical laboratories for determining in vitro susceptibility of bacterial pathogens to these therapeutic agents. Test results are used to determine the antimicrobial agent of choice in the treatment of bacterial diseases." + }, + { + "input": "Concept: BARS (Gene or Genome)", + "output": "something described as this gene plays a role in the repression of both transcription and cell proliferation." + }, + { + "input": "Concept: Sperm neck anomaly (Anatomical Abnormality)", + "output": "Teratozoospermia described as a structural abnormality of the sperm neck." + }, + { + "input": "Concept: Orthography (Linguistics)", + "output": "something described as art and formal rules of writing and spelling according to accepted usage. Also used to refer to the representation of the sounds of a language by written symbols." + }, + { + "input": "Concept: Bronchomalacias (Degenerative disorder)", + "output": "Lesion of bronchus described as a congenital or acquired abnormality of the wall of the bronchi. In congenital cases, there is lack of rigidity in the cartilage of the bronchial wall. In acquired cases, the cartilage of the bronchial wall is degenerated, secondary to tracheostomy or presence of a breathing tube. Symptoms include noisy breathing and wheezing." + }, + { + "input": "Concept: Information Systems, Data Management, Case Management (Intellectual Product)", + "output": "Intellectual Product described as data management information systems designed to streamline work-flow, increase productivity, and improve patient throughput. These systems typically consist of a combination of hardware and software. The hardware typically includes dedicated network servers and computers; the software consists of a dedicated software package that is able to create, update, and review care plans, which improves the capture of clinical data and makes information much more accessible. Case management systems also assist in appropriate reporting of clinical/patient information; they may function as stand-alone systems or may be integrated in a hospital-wide data management information system network." + }, + { + "input": "Concept: DIFFICULTY WALKING (Gait abnormality)", + "output": "other orthopedic disorders described as limitation of independent movement within the environment on foot." + }, + { + "input": "Concept: X-linked diffuse leiomyomatosis with Alport syndrome (Neoplastic disease of uncertain behavior)", + "output": "Alport Syndrome, X-Linked described as the association of X-linked Alport syndrome with leiomyomatosis of the esophagus, tracheobronchial tree or female genitals has been reported in more than 30 families. The disease is due to a deletion involving the 5' terminal region of both COL4A5 and COL4A6 (as such, it forms a contiguous gene syndrome). Only the first two exons of COL4A6 are deleted but the extent of COL4A5 gene deletion is variable." + }, + { + "input": "Concept: DIABLO (Amino Acid, Peptide, or Protein)", + "output": "Apoptosis Regulatory Proteins described as diablo homolog, mitochondrial (239 aa, ~27 kDa) is encoded by the human DIABLO gene. This protein plays a role in the activation of caspase-dependent apoptosis." + }, + { + "input": "Concept: BACS104D (Intellectual Product)", + "output": "something described as brief Assessment of Cognition in Schizophrenia Questionnaire - Verbal Fluency-Total number of Verbal Fluency items." + }, + { + "input": "Concept: 3''-Tert-butyl-4'-(2-hydroxyethoxy)-4''-(pyrrolidin-1-yl)(1,1':3',1'')terphenyl-4-carboxylic Acid (Antiacne agent)", + "output": "Terphenyl Compounds described as a selective retinoic acid receptor gamma (RAR gamma) agonist that can be used in the treatment of acne vulgaris. Upon topical application, trifarotene selectively binds to the RAR gamma receptor, thereby altering the expression of certain genes that are involved in inflammation and cellular differentiation." + }, + { + "input": "Concept: Fluoroscopic Timers (Timer, device)", + "output": "Medical Device described as timers designed for automated measuring of the active duration of exposure to x-rays during a fluoroscopic diagnostic imaging procedure. These timers typically consist of an x-ray detector that is placed in the beam path while an exposure is made, an electronic time measuring instrument, and a display. Radiographic/fluoroscopic timers are usually dedicated instruments intended for use with a variety of radiographic and fluoroscopic units (e.g., half- and/or full-wave generator); timers that are hard-wired to the control unit of radiographic/fluoroscopic units are frequently an integral part of those units. Stand-alone radiographic/fluoroscopic timers are used mainly for inspection, calibration, and/or quality control of diagnostic x-ray generators and units; the timers are frequently an integral component of kilovolt meter instruments used for quality control." + }, + { + "input": "Concept: embryonic dorsal fin morphogenesis (Organism Function)", + "output": "dorsal fin morphogenesis described as the process, occurring in the embryo, by which the anatomical structures of the dorsal fin are generated and organized. A dorsal fin is an unpaired medial fin on the dorsal aspect of a fish that provides lateral stability while swimming. Generally fish have one or two dorsal fins." + }, + { + "input": "Concept: regulation of SMAD protein complex assembly (regulation of protein-containing complex assembly)", + "output": "something described as any process that modulates the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins." + }, + { + "input": "Concept: firesetting (Disruptive, Impulse Control, and Conduct Disorders)", + "output": "Obsessive compulsive behavior described as a disorder characterized by a fascination with fire and recurrent episodes of fire setting during which the individual experiences a rising subjective sense of tension before the fire setting and a sense of gratification or relief when setting the fire. There is no ulterior motive (such as monetary gain or the expression of political ideology) to the fire setting." + }, + { + "input": "Concept: Abnormal Pigmentation (Skin, Human)", + "output": "something described as an abnormality in the formation or distribution of pigment in the skin, hair or nails." + }, + { + "input": "Concept: abuse; inhalant (Psychoactive substance abuse)", + "output": "Antisocial Behavior & Behavior Disorders described as illicit use of chemicals and products whose vapors can be inhaled to produce a rapid mind-altering effect. Inhalants include aerosols, gases, and volatile solvents that are often inhaled repeatedly to achieve the short-lived intoxicating effect." + }, + { + "input": "Concept: Phenyloxirane (Organic Chemical)", + "output": "Epichlorohydrin described as a synthetic, colorless liquid that is very soluble in water. Styrene oxide is used as a chemical intermediate in the production of styrene glycol and its derivatives, cosmetics, surface coatings and other chemicals (agricultural and biological). It is also used as a reactive diluent for epoxy resins and in cross-linked polyesters and polyurethanes. Humans in the general population may be exposed to styrene oxide by contact with contaminated air or water. It is reasonably anticipated to be a human carcinogen." + }, + { + "input": "Concept: Nannizzia persicolor (Sabouraud) Stockdale (Class Ascomycetes)", + "output": "Arthroderma described as a species of dermatophyte fungi in the genus Arthroderma." + }, + { + "input": "Concept: cor triloculare biatriatum (Ventricular Septal Defects)", + "output": "Heart Ventricle described as an umbrella term used to describe several very different complex congenital heart defects that share the same problem: the heart has only one functional ventricle (anatomically right or left or indeterminate) supplying the systemic circulation. These defects include tricuspid atresia, hypoplastic left or right heart syndrome, double outlet right ventricle, double inlet left ventricle, and other forms of single ventricle defects." + }, + { + "input": "Concept: Grade 1 Bronchopulmonary hemorrhage (Bronchopulmonary Hemorrhage, CTCAE 5)", + "output": "Finding described as mild symptoms; intervention not indicated" + }, + { + "input": "Concept: Ovens, Laboratory, Forced-Air, Convection, Plasma Thawing (Forced-air laboratory oven)", + "output": "something described as forced-air convection laboratory ovens intended for thawing and/or warming frozen plasma and/or other related products (e.g., whole blood, erythrocytes, cryopreparations) in a dry environment. Typically heat is transferred from a heat plate by conduction and also by forced-air convection to the plasma bag. These devices usually consist of a tabletop unit that includes an enclosure where the plasma bags are inserted, electronic processing circuits, heating elements, a blower, temperature sensors and controls, and data output ports to keep record of the process. The ovens may also include some means to provide gentle agitation (e.g., rocking) to the bags during the thawing/warming process. Plasma thawing forced-air ovens are mainly used in laboratories, blood banks, and trauma centers to thaw and/or warm blood products close to body temperature (i.e., 37 degrees Celsius/98.5 degrees Fahrenheit) prior to transfusion." + }, + { + "input": "Concept: INR Increased, CTCAE (Finding)", + "output": "Finding described as a finding based on laboratory test results that indicate an increase in the ratio of the patient's prothrombin time to a control sample in the blood." + }, + { + "input": "Concept: light scan (Inspection)", + "output": "Procedure categorized by device involved described as passage of light through body tissues or cavities for examination of internal structures." + }, + { + "input": "Concept: serotonin binding (organic cyclic compound binding)", + "output": "amine binding described as interacting selectively and non-covalently with serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." + }, + { + "input": "Concept: down-regulation of cyclic nucleotide-activated ion channel activity (regulation of cyclic nucleotide-gated ion channel activity)", + "output": "something described as any process that stops, prevents or reduces the frequency, rate or extent of cyclic nucleotide-gated ion channel activity." + }, + { + "input": "Concept: nutritional supplement drink (Food)", + "output": "Dietary Supplements described as a nutritional drink that may help people who cannot get everything they need in their diet from foods and other drinks. It may be taken by mouth or given through a small tube inserted through the nose into the stomach or the small intestine. It may also be given through a small tube that is put into the stomach or intestinal tract through an opening made on the outside of the abdomen. Ensure is a type of dietary supplement." + }, + { + "input": "Concept: Pre-filled injector (Medical Device)", + "output": "something described as filled container, usually fitted with an injection needle, containing a sterile, single-dose parenteral preparation. This term is only to be used when a more-specific term such as 'Pre-filled syringe' or 'Pre-filled pen' is not appropriate. Comment: This term may be used to describe, for example, an item of packaging that is intended to be used by puncturing the skin and squeezing a small reservoir to administer its contents." + }, + { + "input": "Concept: CSS08-Interrupted Attempt, Describe (Intellectual Product)", + "output": "something described as columbia-Suicide Severity Rating Scale Children's Since Last Visit - Description of interrupted attempt." + }, + { + "input": "Concept: Toxicology Finding (Laboratory test finding)", + "output": "Finding described as the results of any analysis that determine the toxicity of a chemical compound." + }, + { + "input": "Concept: air filtration (air pollution control)", + "output": "Occupational Activity described as process of separating particulate matter from air, by passing the air through a medium that will not pass the particulates." + }, + { + "input": "Concept: pN1a Exocrine Pancreatic Carcinoma (Finding)", + "output": "something described as exocrine pancreatic cancer with metastasis to a single regional lymph node." + }, + { + "input": "Concept: Oxidoreductase (Substance categorized by disposition)", + "output": "something described as catalyses oxidation/reduction reactions." + }, + { + "input": "Concept: Transmucosal Route of Drug Administration (Drug Administration Routes)", + "output": "something described as administration across the mucosa." + }, + { + "input": "Concept: cerebellar fissures (Cerebellum)", + "output": "Fissure described as surface indentations of the cerebellum. They include the primary fissure of the cerebellum, which separates the anterior lobe of the cerebellum from the posterior lobe of the cerebellum; the posterior superior fissure, the horizontal fissure of the cerebellum and the prepyramidal fissure of the posterior lobe; and the posterolateral fissure, which separates the posterior lobe of the cerebellum from the flocculonodular lobe ( Carpenter-1983 )." + }, + { + "input": "Concept: gastric bubble (Medical Balloon Device)", + "output": "BAGS, BALLOONS AND BOTTLES described as an inflatable device implanted in the stomach as an adjunct to therapy of morbid obesity. Specific types include the silicone Garren-Edwards Gastric Bubble (GEGB), approved by the FDA in 1985, and the Ballobes Balloon." + }, + { + "input": "Concept: Growth Chart (Research or Clinical Assessment Tool)", + "output": "Intellectual Product described as graphic displays of height and weight showing development over time." + }, + { + "input": "Concept: limit setng asistnce (Common nursing interventions II)", + "output": "Psychosocial intervention strategy described as establishing the parameters of desirable and acceptable patient behavior" + }, + { + "input": "Concept: EPHA8 wt Allele (Gene or Genome)", + "output": "Gene or Genome described as human EPHA8 wild-type allele is located in the vicinity of 1p36.12 and is approximately 40 kb in length. This allele, which encodes ephrin type-A receptor 8 protein, plays a role in mediating developmental events such as short-range contact-mediated axonal guidance during nervous system development." + }, + { + "input": "Concept: trout/salmon (Fish)", + "output": "something described as various fish of the family Salmonidae." + }, + { + "input": "Concept: peptidyl-tyrosine dephosphorylation (Protein dephosphorylation)", + "output": "Protein dephosphorylation described as the removal of phosphoric residues from peptidyl-O-phospho-tyrosine to form peptidyl-tyrosine." + }, + { + "input": "Concept: SHOULDER DYSTOCIA UNSPECIFIED (Shoulder Dystocia)", + "output": "something described as shoulder dystocia occurs when the fetal anterior shoulder impacts against the maternal symphysis following delivery of the vertex." + }, + { + "input": "Concept: Delta12-linoleate epoxygenase activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the reaction: H+ + 1-palmitoyl-2-linoleoyl-phosphatidylcholine + NADPH + O2 <=> 1-palmitoyl-2-vernoloyl-phosphatidylcholine + NADP + H2O." + }, + { + "input": "Concept: Alpha-1-fetoprotein (Trisomy 21 risk)", + "output": "embryo/fetus protein described as the first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life." + }, + { + "input": "Concept: colposcope (Obstetrical/gynecological device)", + "output": "Microscopes described as instruments inserted into the vagina for examination of the tissues of the vagina and cervix by means of a magnifying lens." + }, + { + "input": "Concept: Skin Squamous Cell Carcinoma or Other Skin Carcinomas pNX TNM Finding v7 (Finding)", + "output": "Skin Squamous Cell Carcinoma or Other Skin Carcinomas Pathologic Regional Lymph Nodes TNM Finding v7 described as skin squamous cell carcinoma or other skin carcinomas in which regional lymph nodes cannot be assessed." + }, + { + "input": "Concept: Formocresols (formaldehyde)", + "output": "Cresols described as compounds consisting of formaldehyde, cresol, GLYCERIN, and water. They are used in the PULPOTOMY of PRIMARY TEETH and as ROOT CANAL IRRIGANTS." + }, + { + "input": "Concept: Naloxegol (N [Preparations])", + "output": "Opioid Antagonist [EPC] described as a pegylated form of naloxone, a peripherally-acting mu-opioid receptor antagonist, that can be used to reduce opioid-induced symptoms. Upon administration, naloxegol binds to and blocks mu-opioid receptors in the peripheral nervous system. This prevents peripheral opioid receptor activation and abrogates opioid-induced side effects, such as opioid-induced constipation (OIC). Pegylation of naloxone reduces permeability across the blood-brain barrier (BBB) and prevents this agent from interfering with the analgesic activity of opioid receptor agonists." + }, + { + "input": "Concept: Fitzpatrick Skin Type VI (Finding)", + "output": "something described as skin which is dark brown or black and it never burns when exposed to the sun." + }, + { + "input": "Concept: Proteolytic Enzyme (Substance categorized by disposition)", + "output": "Amino Acid, Peptide, or Protein described as enzymes produced and secreted by the pancreas which aid in the proteolysis of proteins in the digestive tract. Pancreatic proteolytic enzymes include trypsin, chymotrypsin and carboxypeptidase; these enzymes are secreted as zymogens, inactive precursors of the enzymes, and are activated in the lumen of the digestive canal. Another proteolytic enzyme, enteropeptidase, is associated with the brush border of enterocytes; this enzyme catalyses the conversion of trypsinogen into trypsin which, in turn, can activate a number of other pancreatic zymogens. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C38728\" active clinical trials using this agent." + }, + { + "input": "Concept: mitochondrial isopropylmalate transmembrane transport (Cell Function)", + "output": "Cell Function described as the process in which 2-isopropylmalate(2-) is transported across a mitochondrial membrane, into or out of the mitochondrion." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, CLN2 (Medical Device)", + "output": "something described as molecular assay reagents intended to identify mutations in the ceroid-lipofuscinosis, neuronal 2 (CLN2) gene, located at chromosome 11p15, which encodes for nonspecific lysosomal peptidase that generates tripeptides. Mutations at this locus have been identified in patients with infantile late-onset neuronal ceroid-lipofuscinoses (NCL) type 2." + }, + { + "input": "Concept: abnormal umbilical cord long (Finding of lesion)", + "output": "Deformity described as increased length of the umbilical cord." + }, + { + "input": "Concept: Lipoma of stomach (Benign neoplasm of stomach)", + "output": "Lipoma described as a rare benign adipose tissue neoplasm of the stomach. Clinical presentation includes obstruction and gastrointestinal bleeding. Gastric lipomas occur as solitary lesions most frequently in the antrum." + }, + { + "input": "Concept: mitotic sister chromatid cohesion at telomere (Mitotic Sister Chromatid Cohesion)", + "output": "Cell Function described as the cell cycle process in which telomeres of sister chromatids are joined during mitosis." + }, + { + "input": "Concept: protein-carbohydrate complex subunit organization (protein-containing complex subunit organization)", + "output": "Cell Function described as any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-carbohydrate complex." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Serology, Bacteria, Brucella abortus, Antibody (Medical Device)", + "output": "Medical Device described as serology reagents intended to detect antibodies to Brucella abortus, a coccobacillus bacterium. These bacteria are an etiologic agent of brucellosis, a disease characterized by intermittent (i.e., undulant) fever." + }, + { + "input": "Concept: CSPPT (Cardiovascular finding)", + "output": "something described as the time point during the cardiac cycle when the prolapse of one or more cardiac valve cusps occurs." + }, + { + "input": "Concept: SHPS-1 (Receptor Gene)", + "output": "something described as this gene is involved in cellular signal transduction and tyrosine kinase-coupled signaling processes." + }, + { + "input": "Concept: FMN catabolic process (FMN metabolic process)", + "output": "ribonucleotide catabolic process described as the chemical reactions and pathways resulting in the breakdown of FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." + }, + { + "input": "Concept: Increased carrying angle (Limb structure)", + "output": "Finding described as an abnormal increase in the carrying angle, which is the angle he long axis of the extended forearm as it lies lateral to the long axis of the arm." + }, + { + "input": "Concept: Uterine Corpus Leiomyosarcoma and Endometrial Stromal Sarcoma pM1 TNM Finding v8 (Uterine Corpus Leiomyosarcoma and Endometrial Stromal Sarcoma Pathologic Distant Metastasis TNM Finding v8)", + "output": "something described as uterine corpus leiomyosarcoma or endometrial stromal sarcoma with distant metastasis (excluding adnexa, pelvic, and abdominal tissues)." + }, + { + "input": "Concept: Periorbital dermoid cyst (Disease or Syndrome)", + "output": "something described as a cyst that is localized in the region of the orbit and exhibits an epithelial lining with a keratin-filled lumen. Hair follicles are one of the adnexal structures that are commonly found in walls of dermoid cysts. []" + }, + { + "input": "Concept: Inadequate boron intake (Finding)", + "output": "Finding described as lower intake of boron compared to established reference standards or recommendations based on physiological needs (Source: International Dietetics and Nutrition Terminology (IDNT) Reference Manual, edition 4; ISBN #978-0-88091-467-3)" + }, + { + "input": "Concept: ResourceProvider.identifier (Intellectual Product)", + "output": "Identifier described as a unique symbol that establishes identity of the resource provider." + }, + { + "input": "Concept: 2: 213228793-212072321 (Spatial Concept)", + "output": "Chromosome 2 Physical Location described as physical location of ERBB4_Gene" + }, + { + "input": "Concept: ED1R (Gene or Genome)", + "output": "something described as human EDAR wild-type allele is located in the vicinity of 2q13 and is approximately 95 kb in length. This allele, which encodes tumor necrosis factor receptor superfamily member EDAR protein, plays a role in the development of ectodermally derived tissues. Mutation of the gene is associated with hypohidrotic ectodermal dysplasia types 10A and 10B." + }, + { + "input": "Concept: Hypermethioninemia encephalopathy due to deficiency of adenosine kinase (Disease or Syndrome)", + "output": "Brain Diseases, Metabolic described as a rare inborn error of metabolism characterized by persistent hypermethioninemia with increased levels of S-adenosylmethionine and S-adenosylhomocysteine which manifests with encephalopathy, severe global developmental delay, mild to severe liver dysfunction, hypotonia and facial dysmorphism (most significant is frontal bossing, macrocephaly, hypertelorism and depressed nasal bridge). Epileptic seizures, hypoglycemia and/or cardiac defects (pulmonary stenosis, atrial and/or ventricular septal defect, coarctation of the aorta) may be associated. Clinical picture may range from neurological symptoms only to multi-organ involvement. There is evidence the disease is caused by homozygous mutation in the ADK gene on chromosome 10q22." + }, + { + "input": "Concept: sepal formation (floral organ formation)", + "output": "something described as the process that gives rise to the sepal. This process pertains to the initial formation of a structure from unspecified parts." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Immunoassay, Vitamin, B12 (Medical Device)", + "output": "IVD Test Reagent/Kits, Immunoassay, Vitamin described as immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., serum, urine) to determine vitamin B12, the generic descriptor of a group of biologically active substances known as cobalamins. Vitamin B12 is frequently identified with cobalamins that have similar biological activity as cyanocobalamin. Decreased levels of vitamin B12 are associated with pernicious anemia. Deficiency of vitamin B12 may cause neurologic disorders such as pain and loss of sensation of the limbs, weakness, paralysis, and even dementia that may occur without apparent hematologic changes." + }, + { + "input": "Concept: CHLOROPICRIN (Industrial Aid)", + "output": "Industrial Aid described as a synthetic C-nitro, one-carbon, and organochlorine compound that is a strong lachrymator. Chloropicrin has been used as a chemical warfare agent, fumigant, and pesticide. It is characterized as a slightly oily colorless to yellow liquid with a strong irritating odor, and exposure occurs by inhalation, ingestion, or contact." + }, + { + "input": "Concept: PUL02-Hand(s) to Mouth (Intellectual Product)", + "output": "something described as performance of the Upper Limb Module for DMD Version 2.0 - Hand(s) to mouth." + }, + { + "input": "Concept: epiphysterinum/epiphysterinu (Homeopathic remedies letter E)", + "output": "Pharmacologic Substance described as nosode of epiphysterinum." + }, + { + "input": "Concept: WAARDENBURG SYNDROME TYPE 1 (Disease or Syndrome)", + "output": "something described as a rare autosomal dominant syndrome caused by mutations in the PAX3 gene. It is characterized by hearing loss, dystopia canthorum (widely spaced inner corners of the eyes), and changes in the color of the skin, hair, and eyes." + }, + { + "input": "Concept: positive regulation of fibronectin-dependent thymocyte migration (positive regulation of thymocyte migration)", + "output": "positive regulation of thymocyte migration described as any process that activates or increases the frequency, rate or extent of fibronectin-dependent thymocyte migration." + }, + { + "input": "Concept: Flap Surgical Reconstruction (Therapeutic or Preventive Procedure)", + "output": "Therapeutic or Preventive Procedure described as the surgical transfer of tissue from one site to another while maintaining its own blood supply." + }, + { + "input": "Concept: histone-arginine kinase activity (histone kinase activity)", + "output": "arginine kinase activity described as catalysis of the reaction: histone L-arginine + ATP = histone N(omega)-phospho-L-arginine + ADP + 2 H(+)." + }, + { + "input": "Concept: Clean Rooms, Laminar Air Flow, Mobile (Laminar airflow unit)", + "output": "something described as laminar air flow clean rooms mounted on casters or other means for ease of movement. These clean rooms typically provide a very low particle content environment; class 100 or better (ISO 5 or less) are typical, which reduces airborne bacteria in the room environment. The laminar flow may be either vertical (e.g., from the ceiling down) or, less frequently, horizontal, distorted only by objects (e.g., surgical lamps) and staff in the flow pathway. Mobile laminar air flow clean rooms usually consist of a metallic or plastic structure typically including rigid plastic coverings, high-efficiency particulate (HEPA) filters, lighting fixtures, and/or working surfaces. Mobile clean rooms are used to provide a contamination-free environment in field applications (e.g., surgery) and/or for emergency situations in healthcare facilities." + }, + { + "input": "Concept: ng/ml/(ug/kg) (Quantitative Concept)", + "output": "Unit of concentration described as micrograms per milliliter (concentration), divided by milligrams per kilogram (dose normalized by body weight) or nanograms per milliliter (concentration), divided by micrograms per kilogram (dose normalized by body weight)." + }, + { + "input": "Concept: ATP-dependent 5' to 3' DNA/RNA helicase activity (Genetic Function)", + "output": "something described as catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of a DNA/RNA duplex in the direction 5' to 3'." + }, + { + "input": "Concept: cAMP-Dependent Protein Kinase Type I-Alpha Regulatory Subunit/Retinoic Acid Receptor Alpha Fusion Protein (Amino Acid, Peptide, or Protein)", + "output": "something described as a fusion protein encoded by the PRKAR1A/RARA fusion gene. This protein is comprised of the N-terminal protein dimerization domain of the cAMP-dependent protein kinase type I-alpha regulatory subunit protein fused to the C-terminal DNA and ligand binding domains of the retinoic acid receptor alpha protein." + }, + { + "input": "Concept: Stage IIIC Fallopian Tube Cancer (Stage III Fallopian Tube Cancer AJCC v7)", + "output": "something described as stage IIIC includes: (T3c, N0, M0); (Any T, N1, M0). T3c: Peritoneal metastasis outside the pelvis and more than 2 cm in diameter. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis." + }, + { + "input": "Concept: CSS09-Non-suicidal Self-injur Behav (Intellectual Product)", + "output": "Intellectual Product described as columbia-Suicide Severity Rating Scale Screening - Has subject engaged in non-suicidal self-injurious behavior?" + }, + { + "input": "Concept: Tape (Device Component or Accessory)", + "output": "something described as a long, thin, flat, flexible material often used for measuring, binding or fastening, or as a recording medium." + }, + { + "input": "Concept: Acute pancreatitis (Classification)", + "output": "Classification described as drug-induced pancreatitis is usually an acute condition. If clinically suspected, it should always be confirmed by biochemical investigations - Definition of acute pancreatitis: o An inflammatory disease of the pancreas characterized by upper abdominal pain and vomiting; in severe cases - abdominal guarding, rigidity, rebound tenderness and diminution or loss of bowel sounds o Almost always accompanied by increased pancreatic enzymes - amylase and lipase - in the blood and urine o Other signs/findings are icterus, increased alkaline phosphatase and/or bilirubin, ileus, ascites, hyperglycemia, hypocalcemia and leukocytosis o Cullen's sign is sometimes associated with severe necrotizing pancreatitis - Severe attacks may lead to shock with renal and pulmonary insufficiency, which may be fatal." + }, + { + "input": "Concept: Prototheca W.Krueger, 1894 (Chlorellaceae)", + "output": "Algae described as a genus of green algae in the family Chlorellaceae and phylum Chlorophyta." + }, + { + "input": "Concept: EPIC2-Quality of Your Erections (Intellectual Product)", + "output": "something described as expanded Prostate Cancer Index Composite for Clinical Practice (EPIC-CP) How would you describe the usual quality of your erections?" + }, + { + "input": "Concept: Hypercytokinemia (Other specified disorders involving the immune mechanism, not elsewhere classified in ICD10CM)", + "output": "Other specified disorders involving the immune mechanism, not elsewhere classified in ICD10CM described as a syndrome that occurs after therapeutic infusion of antibodies into the blood and is characterized by nausea, headache, tachycardia, hypotension, rash, and shortness of breath. It is caused by the release of cytokines from the cells that are targeted by the antibodies. Most patients experience a mild to moderate reaction; however, the reaction may be severe and life-threatening." + }, + { + "input": "Concept: Phacoemulsification Units (Medical Device)", + "output": "something described as a phacofragmentation system is an AC-powered device with a fragmenting needle intended for use in cataract surgery to disrupt a cataract with ultrasound and extract the cataract." + }, + { + "input": "Concept: Parabacteroides johnsonii Sakamoto et al. 2007 emend. Hahnke et al. 2016 (Bacterium)", + "output": "something described as any bacterial organism that can be assigned to the species Parabacteroides johnsonii." + }, + { + "input": "Concept: geranylgeranyl pyrophosphate synthase activity (Molecular Function)", + "output": "prenyltransferase activity described as catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate." + }, + { + "input": "Concept: broad-complex, tramtrack, and bric-a-brac domain binding (Molecular Function)", + "output": "something described as interacting selectively and non-covalently with a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors." + }, + { + "input": "Concept: FLJ31051 (Gene or Genome)", + "output": "Gene or Genome described as human IKBIP wild-type allele is located in the vicinity of 12q23.1 and is approximately 31 kb in length. This allele, which encodes inhibitor of nuclear factor kappa-B kinase-interacting protein, is involved in the promotion of apoptosis." + }, + { + "input": "Concept: up regulation of neurotransmitter secretion (regulation of neurotransmitter secretion)", + "output": "positive regulation of synaptic transmission described as any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter." + }, + { + "input": "Concept: GAPDH wt Allele (GAPDH gene)", + "output": "something described as human GAPDH wild-type allele is located in the vicinity of 12p13.31 and is approximately 4 kb in length. This allele, which encodes glyceraldehyde-3-phosphate dehydrogenase protein, plays a role in carbohydrate metabolism." + }, + { + "input": "Concept: CARD11 wt Allele (Gene or Genome)", + "output": "Gene or Genome described as human CARD11wild-type allele is located within 7p22 and is 138 kb in length. This allele, which encodes caspase recruitment domain-containing protein 11, plays a role in apoptosis regulation and signal transduction." + }, + { + "input": "Concept: OPB-31121 (Signal Transduction Inhibitor)", + "output": "Signal Transduction Inhibitor described as an orally bioavailable inhibitor of signal transducer and activator of transcription 3 (STAT3), with potential antineoplastic activity. OPB-31121 inhibits the phosphorylation of STAT3, which prevents binding of STAT3 to DNA sequences on a variety of STAT3-responsive promoters and may result in the inhibition of STAT3-mediated transcription and, potentially, the inhibition of tumor cell proliferation. STAT3 is constitutively activated in a variety of cancers, contributing to the loss of cell growth control and neoplastic transformation. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C90588\" active clinical trials using this agent." + }, + { + "input": "Concept: bowel habits (Digestion)", + "output": "rectal function described as the way the intestines work in terms of how often there are bowel movements, the ability to control when to have a bowel movement, and whether the stools are hard and dry as in constipation or watery as in diarrhea." + }, + { + "input": "Concept: UPD2302 (MDS-UPDRS Questionnaire Question)", + "output": "MDS-UPDRS Questionnaire Question described as the Movement Disorder Society version of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Facial expression." + }, + { + "input": "Concept: HEAG (Laboratory Procedure)", + "output": "something described as a measurement of the Hepatitis E virus antigen in a biological specimen." + }, + { + "input": "Concept: dynamin family protein polymerization involved in mitochondrial fission (dynamin family protein polymerization involved in membrane fission)", + "output": "Molecular Function described as the process of creating dynamin protein family polymers, compounds composed of a large number of dynamin family monomers around a lipid tube of a dividing mitochondrion. Dynamin polymers form around lipid tubes and contribute to membrane fission." + }, + { + "input": "Concept: ANTEROPOSTERIOR (Spatial Concept)", + "output": "Orientation described as directed from front to back." + }, + { + "input": "Concept: Duodenum and Ampulla of Vater Neuroendocrine Tumor pT2 TNM Finding v8 (Finding)", + "output": "Finding described as duodenum neuroendocrine tumor invading the muscularis propria or measuring more than 1 cm; Ampulla of Vater neuroendocrine tumor invading through the sphincter of Oddi into duodenal submucosa or muscularis propria, or measuring more than 1 cm." + }, + { + "input": "Concept: Quercetin 3-rutinoside (Flavonols)", + "output": "quercetin described as a flavonol glycoside found in many plants, including BUCKWHEAT; TOBACCO; FORSYTHIA; HYDRANGEA; VIOLA, etc. It has been used therapeutically to decrease capillary fragility." + }, + { + "input": "Concept: Vitreous floaters (General visual observation)", + "output": "Disorder of vitreous body described as deposits of various size, shape, consistency, refractive index, and motility within the eye's vitreous humour, which is normally transparent." + }, + { + "input": "Concept: VENOUS THROMBOEMBOLISM (Thromboembolism)", + "output": "Thromboembolism described as obstruction of a vein or VEINS (embolism) by a blood clot (THROMBUS) in the blood stream." + }, + { + "input": "Concept: FAMILY PSYCHODIDAE - MOTH FLIES AND PHLEBOTOMUS FLIES (Psychodoidea)", + "output": "Eukaryote described as small, hairy, moth-like flies which are of considerable public health importance as vectors of certain pathogenic organisms. Important disease-related genera are PHLEBOTOMUS, Lutzomyia, and Sergentomyia." + }, + { + "input": "Concept: Patient-Specific Modeling (Biological Models)", + "output": "Biological Models described as the development and application of computational models of human pathophysiology that are individualized to patient-specific data." + }, + { + "input": "Concept: Perfusion Magnetic Resonance Imaging (Magnetic Resonance Imaging)", + "output": "something described as a special type of magnetic resonance imaging (MRI) that uses an injected dye in order to see blood flow through tissues." + }, + { + "input": "Concept: Reductase, Glutathione (Enzymes)", + "output": "something described as catalyzes the oxidation of GLUTATHIONE to GLUTATHIONE DISULFIDE in the presence of NADP+. Deficiency in the enzyme is associated with HEMOLYTIC ANEMIA. Formerly listed as EC 1.6.4.2." + }, + { + "input": "Concept: FAC100-Limit: Putting on Socks (Intellectual Product)", + "output": "something described as functional Assessment of Chronic Illness Therapy-Dyspnea Scale 33 Item Bank - Functional Limitation: Considering your shortness of breath over the past 7 days, rate the amount of difficulty you had when doing the following activities: Putting on socks or stockings." + }, + { + "input": "Concept: Basophil Band Form Count (White Blood Cell Count procedure)", + "output": "something described as the determination of the number of band basophils in a sample." + }, + { + "input": "Concept: CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment (CD4-positive, alpha-beta T cell lineage commitment)", + "output": "something described as the process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell." + }, + { + "input": "Concept: peptidyl-S-carbamoyl-L-cysteine dehydration (protein dehydration)", + "output": "protein dehydration described as the dehydration of peptidyl-S-carbamoyl-L-cysteine to form peptidyl-S-cyano-L-cysteine." + }, + { + "input": "Concept: choroid uvea (Body Part, Organ, or Organ Component)", + "output": "Uvea described as thin, highly vascular membrane covering most of the posterior of the eye between the retina and sclera." + }, + { + "input": "Concept: galactose to glucose-1-phosphate metabolic process (Galactose Metabolism Pathway)", + "output": "Galactose Metabolism Pathway described as the chemical reactions and pathways in which galactose, the aldohexose galacto-hexose, is converted to glucose-1-phosphate." + }, + { + "input": "Concept: X-Ray Filter Material (Manufactured Object)", + "output": "something described as x-Ray absorbing material used in the filter." + }, + { + "input": "Concept: Reduced creatinine clearance (Finding)", + "output": "Kidney Function Tests described as an abnormal reduction in the volume of fluid filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time." + }, + { + "input": "Concept: Amaranth leaf product (Azo Dyes)", + "output": "Food Coloring Agents described as a sulfonic acid-based naphthylazo dye used as a coloring agent for foodstuffs and medicines and as a dye and chemical indicator. It was banned by the FDA in 1976 for use in foods, drugs, and cosmetics." + }, + { + "input": "Concept: Drug Stability Duration (Temporal Concept)", + "output": "Temporal Concept described as the period of time during which the drug is considered usable after it is activated (opened)." + }, + { + "input": "Concept: SUHW5 (POGZ gene)", + "output": "something described as human POGZ wild-type allele is located in the vicinity of 1q21.3 and is approximately 57 kb in length. This allele, which encodes pogo transposable element with ZNF domain protein, plays a role in the progression of mitosis." + }, + { + "input": "Concept: cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II) (Pharmacologic Substance)", + "output": "something described as a second-generation platinum compound with a broad spectrum of antineoplastic properties. Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue. This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These carboplatin-induced DNA and protein effects result in apoptosis and cell growth inhibition. This agent possesses tumoricidal activity similar to that of its parent compound, cisplatin, but is more stable and less toxic." + }, + { + "input": "Concept: Anaplastic Large Cell Lymphoma, Sarcomatoid Subtype (Neoplastic Process)", + "output": "Ki-1+ Anaplastic Large Cell Lymphoma described as a are variant of anaplastic large cell lymphoma. It is characterized by presence of large spindle shaped cells resembling a soft tissue sarcoma." + }, + { + "input": "Concept: GASTROINTESTINAL TRACT, UPPER (Subdivision of gastrointestinal system)", + "output": "Upper Gastrointestinal Tract described as esophagus, stomach, and duodenum" + }, + { + "input": "Concept: Nephelometric Immunoassay Analyzers (Medical Device)", + "output": "something described as immunoassay analyzers that use a dedicated nephelometer, which measures particulates suspended in liquid or gas, as detection system. These analyzers can be used to monitor immunoassays that produce antigen-antibody complexes (e.g., enzyme immunoassays) that are capable of scattering monochromatic light at a particular wavelength." + }, + { + "input": "Concept: NECL2 (Gene or Genome)", + "output": "something described as this gene plays a role in cell-cell adhesion." + }, + { + "input": "Concept: Low Absorption Reticulocytes (Reticulocyte count)", + "output": "something described as a measurement of the low absorption reticulocytes in a biological specimen." + }, + { + "input": "Concept: Histone Acetylation (histone modification)", + "output": "histone modification described as histone Acetylation involves covalent linkage of acetyl groups to highly basic histone proteins associated with DNA, particularly in active chromatin, and may be involved in regulation of gene expression." + }, + { + "input": "Concept: CIRS-G (Research or Clinical Assessment Tool)", + "output": "Research or Clinical Assessment Tool described as a clinical assessment tool designed to measure comorbidity in geriatric cancer patients. The tool grades comorbidity severity from 0-4 in 14 organ systems." + }, + { + "input": "Concept: Spigelian hernia with cryptorchidism syndrome (Multiple system malformation syndrome)", + "output": "Congenital malposition of testis described as a rare developmental defect during embryogenesis with characteristics of ventral, unilateral or bilateral protrusion of extraperitoneal fat, peritoneum and/or intra-abdominal organs through a defect in the spigelian fascia (spigelian hernia), associated with ipsilateral or bilateral undescended testis (usually found within or just beneath the hernial sac) in male neonates. The gubernaculum and/or inguinal canal may be absent." + }, + { + "input": "Concept: Cofactor Required for Sp1 Transcriptional Activation, Subunit 4, 100kDa Gene (Gene or Genome)", + "output": "MED24 gene described as human MED24 wild-type allele is located in the vicinity of 17q21.1 and is approximately 35 kb in length. This allele, which encodes mediator of RNA polymerase II transcription subunit 24 protein, may be involved in transcriptional initiation." + }, + { + "input": "Concept: Depth of respiration (Respiration)", + "output": "Respiration functions described as functions related to the volume of expansion of the lungs during breathing." + }, + { + "input": "Concept: rivoceranib (Organic Chemical)", + "output": "Pharmacologic Substance described as an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. Upon administration, rivoceranib selectively binds to and inhibits vascular endothelial growth factor receptor 2, which may inhibit VEGF-stimulated endothelial cell migration and proliferation and decrease tumor microvessel density. In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases." + }, + { + "input": "Concept: Subdivision of skeletal system (Musculoskeletal System)", + "output": "Musculoskeletal System described as organ system subdivision which has as its direct parts a combination of any of the following structures: skeleton, skeletal membrane organs, skeletal ligaments, bursae, skeletal cartilage organs and portions of synovial fluid." + }, + { + "input": "Concept: regulation of blood coagulation, common pathway (regulation of blood coagulation)", + "output": "Organism Function described as any process that modulates the frequency, rate or extent of blood coagulation, common pathway." + }, + { + "input": "Concept: TNRC6B (Biologically Active Substance)", + "output": "RNA-Binding Proteins described as trinucleotide repeat-containing gene 6B protein (1833 aa, ~194 kDa) is encoded by the human TNRC6B gene. This protein plays a role in RNA-mediated repression of translation." + }, + { + "input": "Concept: upregulation of root hair elongation (positive regulation of plant epidermal cell differentiation)", + "output": "positive regulation of developmental growth described as any process that activates or increases the frequency, rate or extent of root hair elongation." + }, + { + "input": "Concept: Simulators, Bone Sound Conduction, Mastoid (Simulators)", + "output": "something described as simulators designed to mimic the sound conduction characteristics of the human mastoid bone that are mainly intended to assess and calibrate bone-conducting hearing aids. These simulators usually consist of a tabletop electromechanical device that resembles a human head and a force transducer to evaluate the output level and frequency response of the device under assessment following a given standard (e.g., ANSI, IEC). The simulator is mounted on springs to provide isolation from the table. Mastoid simulators are also used to assess the characteristics of audiometer bone vibrators." + }, + { + "input": "Concept: PODCI175 (Intellectual Product)", + "output": "Intellectual Product described as pediatric Outcomes Data Collection Instrument, Pediatric Parent-Reported - How much pain has your child had during the last week?" + }, + { + "input": "Concept: integrin-targeted immunoconjugate IMGN388 (Antineoplastic Antibody)", + "output": "Antineoplastic Antibody-Drug Conjugate described as an immunoconjugate consisting of an anti-integrin monoclonal antibody covalently attached to the maytansinoid DM4, a derivative of the cytotoxic agent maytansine (DM1), with potential antineoplastic activity. Integrin-targeted immunoconjugate IMGN388 binds to tumor cell surface integrins; upon internalization, the DM4 moiety is released from the immunoconjugate, binding to tubulin and disrupting microtubule assembly/disassembly dynamics, which may result in inhibition of cell division and cell growth of integrin-expressing tumor cells. Integrins, a class of transmembrane cell surface receptors, link the extracellular matrix (ECM) to intracellular signaling pathways that control cell proliferation and differentiation." + }, + { + "input": "Concept: Pelvic lipomatosis (Neoplastic Process)", + "output": "Neoplastic Process described as a neoplastic process characterized by a diffuse poorly circumscribed overgrowth of adipose tissue in the pelvic region. Clinical presentation includes complaints of back and abdominal pain, urinary frequency, perineal pain and constipation. It predominately affects black males." + }, + { + "input": "Concept: 10*7/L (Unit of Number Concentration)", + "output": "Unit of Number Concentration described as a unit of measurement equal to 10 to the seventh power of the number of entities per unit of volume equal to one liter." + }, + { + "input": "Concept: TM (Domain)", + "output": "Intellectual Product described as a trial design domain that is used to describe disease milestones, which are observations or activities anticipated to occur in the course of the disease under study, and which trigger the collection of data." + }, + { + "input": "Concept: QIDSC106 (QIDS-C Clinical Classification Question)", + "output": "Intellectual Product described as quick Inventory of Depressive Symptomatology - Clinician-Rated - Please circle one response to each item that best describes the patient for the last seven days: Appetite (decreased)." + }, + { + "input": "Concept: pM1 Carcinoma of the Liver TNM Finding v6 (Finding)", + "output": "Finding described as liver cancer with distant metastasis." + }, + { + "input": "Concept: epithelioma (Neoplasms)", + "output": "Malignant epithelial neoplasm - category described as malignant new growth arising from epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases." + }, + { + "input": "Concept: area 9/46v (Body Location or Region)", + "output": "area 9/46 described as one of two components of area 9/46 in the dorsolateral prefrontal cortex of the human ( Petrides-2012 ) and the macaque ( Petrides-2009 ). Defined on the basis of multiple stains, it is the part of area 9/46 located venral to the middle frontal sulcus in the human and ventral to the principal sulcus in the macaque. The other component is area 9/46d. As granular prefrontal cortex, it has no equivalent in the rat ( Zilles-2012 )." + }, + { + "input": "Concept: extrinsic component of postsynaptic specialization membrane of symmetric synapse (extrinsic component of postsynaptic specialization membrane)", + "output": "extrinsic component of postsynaptic specialization membrane described as the component of the postsynaptic specialization membrane of a symmetric synapse consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." + }, + { + "input": "Concept: maintenance of pre-synaptic active zone structure (Cell Function)", + "output": "maintenance of synapse structure described as a process which maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and docking of vesicles and the release of neurotransmitters." + }, + { + "input": "Concept: NCCN-FACT FOSI-18 Version 2 - Content With Quality of My Life (NCCN-FACT FOSI-18 Version 2 Questionnaire Question)", + "output": "something described as national Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Ovarian Symptom Index-18 Version 2 - I am content with the quality of my life right now." + }, + { + "input": "Concept: In Hospital (Manufactured Object)", + "output": "Hospital environment described as institutions with an organized medical staff which provide medical care to patients." + }, + { + "input": "Concept: Global Alignment of Immunization safety Assessment in pregnancy Level 3a Assessment of Gestational Age (GAIA Gestational Age Levels of Diagnostic Certainty)", + "output": "GAIA Gestational Age Levels of Diagnostic Certainty described as level 3a Assessment of Gestational Age is defined by the presence at least one of the following criteria: a) Certain last menstrual period (LMP) date with third trimester scan (28 0/7 weeks or more); OR b) Certain LMP date with confirmatory second trimester fundal height (FH); OR c) Certain LMP date with birth weight; OR d) Uncertain LMP date with first trimester physical examination." + }, + { + "input": "Concept: IOTN - Index of orthodontic treatment need (Laboratory or Test Result)", + "output": "Orthodontic index described as a dental health survey developed to evaluate a patient's orthodontic treatment need and priority for orthodontic care. The index is based on an assessment of degree of MALOCCLUSION and the potential aesthetic and dental health benefit of the treatment under consideration." + }, + { + "input": "Concept: OR51E2 (G Protein-Coupled Receptor Genes)", + "output": "G Protein-Coupled Receptor Genes described as this gene may play a role in olfactory chemosensation." + }, + { + "input": "Concept: NP 005219.2:p.Leu747 Pro753del (Cell or Molecular Dysfunction)", + "output": "Cell or Molecular Dysfunction described as a deletion of seven amino acids from the epidermal growth factor receptor protein from the leucine at position 747 through the proline at position 753." + }, + { + "input": "Concept: Refractory Thyroid Gland Cancer (Refractory Malignant Thyroid Gland Neoplasm)", + "output": "Refractory Malignant Thyroid Gland Neoplasm described as thyroid gland carcinoma that does not respond to treatment." + }, + { + "input": "Concept: Abnormality of the peripheral nervous system (Finding)", + "output": "something described as any abnormality of the part of the nervous system that consists of the nerves and ganglia outside of the brain and spinal cord." + }, + { + "input": "Concept: Tumor Cell Vaccine plus BCG (Immunologic Factor)", + "output": "Immunologic Factor described as a mixture of allogeneic or autologous tumor cells and bacillus Calmette-Guerin (BCG) in a liquid vehicle with potential antineoplastic activity. Vaccination of the host with tumor cell vaccine plus BCG may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against similar host tumor cells, resulting in decreased tumor growth. The BCG component serves as an adjuvant, a nonspecific stimulator of the immune response." + }, + { + "input": "Concept: Fe (SPECIFIC SUBSTANCE CHEMISTRY TESTS)", + "output": "Heavy metals measurement described as a measurement of the iron in a biological specimen." + }, + { + "input": "Concept: Prodrug BTP 114 (Pharmacologic Substance)", + "output": "Platinum Antineoplastic Compound described as a proprietary, albumin-binding platinum (Pt)-based complex containing a prodrug form of the platinum compound cisplatin and a maleimide moiety, with an ability to strongly and selectively bind human serum albumin (HSA), and with potential antineoplastic activity. Upon intravenous administration, the maleimide group of BTP-114 rapidly conjugates with HSA in the bloodstream; this prolongs the blood circulation, enhances the half-life, and alters the biodistribution of BTP-114, as compared to cisplatin alone. Thus, BTP-114 demonstrates enhanced extravasation to the tumor, an increased accumulation in the tumor tissue and enhanced uptake by cancer cells. The prodrug form is reduced in the hypoxic tumor cell environment, which releases the highly cytotoxic active metabolite cisplatin. Once inside the tumor cell, cisplatin binds to nucleophilic groups, such as GC-rich sites, in DNA and induces intrastrand and interstrand DNA cross-links, resulting in apoptosis and cell growth inhibition. Compared to cisplatin alone, BTP-114 has improved selectivity towards tumor tissue, thereby enhancing efficacy while reducing systemic toxicities." + }, + { + "input": "Concept: Clorfenvinfos (Organophosphate insecticide)", + "output": "something described as an organophosphorus cholinesterase inhibitor that is used as an insecticide and an acaricide." + }, + { + "input": "Concept: negative regulation of protein-pyridoxal-5-phosphate linkage (Molecular Function)", + "output": "regulation of protein-pyridoxal-5-phosphate linkage described as any process that stops, prevents or reduces the frequency, rate or extent of protein-pyridoxal-5-phosphate linkage." + }, + { + "input": "Concept: respiratory chain complex II assembly (Molecular Function)", + "output": "Molecular Function described as the aggregation, arrangement and bonding together of a set of components to form respiratory chain complex II." + }, + { + "input": "Concept: KRT19 (KRT19 gene)", + "output": "something described as human KRT19 wild-type allele is located in the vicinity of 17q21.2 and is approximately 5 kb in length. This allele, which encodes keratin, type I cytoskeletal 19 protein, plays a role in muscle fiber organization." + }, + { + "input": "Concept: Chorioretinal lacunae (Eye)", + "output": "something described as punched out lesions in the pigmented layer of the retina." + }, + { + "input": "Concept: Stage IVB Fallopian Tube Cancer (Neoplastic Process)", + "output": "something described as stage IVB includes: Any T, Any N, M1b. M1b: Fallopian tube cancer with liver or splenic parenchymal metastases; metastases to extra-abdominal organs (including inguinal lymph nodes and lymph nodes outside the abdominal cavity); transmural involvement of intestine." + }, + { + "input": "Concept: Prostheses, Lower Limb, Total (External lower-limb prosthesis)", + "output": "Medical Device described as lower limb prostheses designed for partial functional (e.g., rotation, flexion) replacement of a completely missing limb (i.e., the femur and part of the pelvis removed above the hip articulation). These prostheses typically consist of external or partially implantable devices with socket, foot, ankle, knee, and tubular components resembling the leg and thigh; the hip, knee, and ankle components include mechanisms that can provide rotational and flexion movements and locking positions to the components distal to them. Total lower limb prostheses can be anchored directly to the socket lamination plate. They are available in a great variety of configurations and sizes and are used in patients who suffered amputations due to illness (e.g., cancer) or traumatic accidents or, less frequently, in patients who have congenital abnormalities." + }, + { + "input": "Concept: Spinal Cord Neuroblastoma (Neoplastic Process)", + "output": "Malignant neoplasm of spinal cord described as a neuroblastoma that affects the spinal cord." + }, + { + "input": "Concept: down-regulation of cell organization (Cell Function)", + "output": "something described as any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." + }, + { + "input": "Concept: Maximum Observed Excretion Rate (Excretion Rate)", + "output": "Excretion Rate described as the maximum observed excretion rate." + }, + { + "input": "Concept: Cardiac Boards (Support equipment)", + "output": "Medical Device described as a cardiopulmonary resuscitation board is a device consisting of a rigid board which is placed under a patient to act as a support during cardiopulmonary resuscitation." + }, + { + "input": "Concept: {BOX} (Potency Unit)", + "output": "Quantitative Concept described as a dosing unit equal to the amount of active ingredient(s) contained in a box." + }, + { + "input": "Concept: Propanalol (beta antiadrenergic agent)", + "output": "Cardiovascular Agents described as noncardioselective beta adrenergic antagonist; used in treatment or prevention of many disorders including acute myocardial infarction, arrhythmias, angina pectoris, hypertension, hyperthyroidism, migraine; pheochromocytoma, etc." + }, + { + "input": "Concept: CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity (CDP-alcohol phosphatidyltransferase activity)", + "output": "CDP-alcohol phosphatidyltransferase activity described as catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H(+)." + }, + { + "input": "Concept: Smokers, Tobacco (Population Group)", + "output": "something described as persons with a history or habit of SMOKING tobacco." + }, + { + "input": "Concept: DIMETILAN (Pesticides)", + "output": "Pesticides described as a synthetic pyrazole compound and carbamate acetylcholinesterase inhibitor that is used as a pesticide. It is characterized as a colorless or yellow to reddish-brown solid, and exposure occurs by inhalation, ingestion, or contact." + }, + { + "input": "Concept: Residue After Decontamination (Finding)", + "output": "Device Reprocessing Problem described as problem associated with the decontamination process not adequately removing unwanted visible soil, foreign material, or organism deposits." + }, + { + "input": "Concept: U7 snRNA binding (Genetic Function)", + "output": "snRNA binding described as interacting selectively and non-covalently with the U7 small nuclear RNA (U7 snRNA)." + }, + { + "input": "Concept: single-stranded RNA binding (Genetic Function)", + "output": "something described as interacting selectively and non-covalently with single-stranded RNA." + }, + { + "input": "Concept: inner ear receptor stereocilium organisation (neuron projection development)", + "output": "something described as a process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a stereocilium. A stereocilium is an actin-based protrusion from the apical surface of inner ear receptor cells." + }, + { + "input": "Concept: Pounds (Potency Unit)", + "output": "Non-SI unit of mass described as the traditional unit of mass. By international agreement, one avoirdupois pound is equal to exactly 0.453 592 37 kilogram, 16 ounces, or 1.215 28 troy pounds." + }, + { + "input": "Concept: Retrobulbar haematoma (Hemorrhage)", + "output": "Pathologic Function described as accumulation of blood posterior to the globe." + }, + { + "input": "Concept: Class 1b Uveal Melanoma (Neoplastic Process)", + "output": "Class 1 Uveal Melanoma described as uveal melanoma with intermediate metastatic risk as defined by gene expression profiling." + }, + { + "input": "Concept: Musculo-skeletal disorder NOS (German translation of the Medical Subject Headings)", + "output": "Czech translation of the Medical Subject Headings described as a non-neoplastic or neoplastic disorder that affects muscles and bones." + }, + { + "input": "Concept: Chondroma, NOS (Epithelioma)", + "output": "Neoplastic Process described as a benign well circumscribed neoplasm of hyaline cartilage arising from bone or soft tissue. It is characterized by the presence of chondrocytes." + }, + { + "input": "Concept: negative regulation of protein deubiquitination (Molecular Function)", + "output": "negative regulation of protein modification by small protein conjugation or removal described as any process that decreases the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin groups from a protein." + }, + { + "input": "Concept: Abnormality of the posterior pituitary (Anatomical Abnormality)", + "output": "Anatomical Abnormality described as an abnormality of the neurohypophysis, which is also known as the posterior lobe of the hypophysis." + }, + { + "input": "Concept: supragranular cortex (Body Part, Organ, or Organ Component)", + "output": "something described as a cytoarchitectural term denoting two layers of the cerebral cortex, the external granular layer (II) and the external pyramidal layer (III), which are superficial to the internal granular layer (IV) ( Carpenter-1983 )." + }, + { + "input": "Concept: Drug Agonism (Drug Interactions)", + "output": "something described as phenomena and pharmaceutics of compounds that selectively bind to a specific receptor and trigger a response. They mimic the action of endogenous biochemical molecules. Their effect can be countered by antagonists (DRUG ANTAGONISM)." + }, + { + "input": "Concept: Siewert Type I (Intellectual Product)", + "output": "something described as an adenocarcinoma of the lower esophagus with the center located 1 cm to 5 cm above the esophagogastric junction." + }, + { + "input": "Concept: PQL1420 (PedsQL Neuromuscular Module Acute Version 3.0 Child Report Questionnaire Question)", + "output": "something described as pediatric Quality of Life Neuromuscular Module Acute Version 3 Child - In the past 7 days, how much of a problem has this been for you: It is hard for me to explain my illness to other people." + }, + { + "input": "Concept: SIOP/COG/NWTSG Stage III (Intellectual Product)", + "output": "Intellectual Product described as residual Wilms' tumor confined to the abdomen; Lymph nodes in the renal hilum, the periaortic chains, or beyond are found to contain tumor; diffuse peritoneal contamination by the tumor; implants are found on the peritoneal surfaces; tumor extends beyond the surgical margins either microscopically or grossly; tumor is not completely resectable because of local infiltration into vital structures." + }, + { + "input": "Concept: Carboxypeptidase U (Metalloexopeptidases)", + "output": "Metalloexopeptidases described as a carboxypeptidase that removes C-terminal lysine or arginine from peptides and proteins. Carboxypeptidase B2 (CPB2) is released into the circulation as a proenzyme which is activated by the THROMBIN-THROMBOMODULIN complex. Activated CPB2 is involved in modulating a variety of processes by cleaving and inactivating various circulating proteins and peptides that are its substrates including FIBRIN; KININS; and ANAPHYLATOXINS." + }, + { + "input": "Concept: pomegranate-extract pill (Dietary Supplements)", + "output": "something described as a pill formulation of polyphenol extracts derived from the fruit of the deciduous shrub Punica granatum with antioxidant and potential chemopreventive activities. By binding and neutralizing free-radical compounds, the polyphenol extracts contained in pomegranate-extract pill may prevent their genotoxic and carcinogenic effects." + }, + { + "input": "Concept: Hyperphenylalaninemia, NOS (Disorder of phenylalanine metabolism)", + "output": "Abnormal circulating phenylalanine concentration described as any of several autosomal recessive defects in the hydroxylation of phenylalanine resulting in accumulation and excretion of dietary phenylalanine; most commonly the defect is in the enzyme phenylalanine 4-monooxygenase; the most severe manifestation of this is classic PHENYLKETONURIA, but two benign forms also occur; rarely the defect is one of tetrahydrobiopterin metabolism." + }, + { + "input": "Concept: Severity of Symptom Likert Scale (Intellectual Product)", + "output": "something described as a scale for the subjective scoring of symptoms that ranges from 0: Not Present to 10: As Bad as You Can Imagine." + }, + { + "input": "Concept: Serological (General Qualifier)", + "output": "something described as pertaining to the in vitro reactions and properties of immune sera, particularly, the concept refers to the use of such reactions to measure serum titers of antibody against infectious and non-infectious agents (serologic tests), to the clinical correlations of the antibody titer, and to the use of serologic reactions to detect antigens." + }, + { + "input": "Concept: small cell osteogenic sarcoma (Bone Sarcoma)", + "output": "Primary malignant neoplasm described as an osteosarcoma usually arising from the metaphysis of long bones. It is characterized by the presence of small cells and osteoid production. The prognosis is usually unfavorable." + }, + { + "input": "Concept: PCM1/JAK2 Fusion Protein (Amino Acid, Peptide, or Protein)", + "output": "Amino Acid, Peptide, or Protein described as a fusion protein that is encoded by the PCM1/JAK2 fusion gene. This protein contains the predicted coiled-coil domains and the ATP/GTP binding domain from pericentriolar material 1 protein and the entire tyrosine kinase domain of the tyrosine-protein kinase JAK2 protein." + }, + { + "input": "Concept: VIP Gene (Peptide Hormone Gene)", + "output": "Gene or Genome described as this gene is involved in neuroendocrine mediation and anti-inflammatory immune responses." + }, + { + "input": "Concept: Double-Walled Nanotube (Nanotubes, Carbon)", + "output": "Nanotubes, Carbon described as a carbon nanotube comprised of two layers of graphitic carbon." + }, + { + "input": "Concept: Abnormal;test result;urine (Urine screening abnormal)", + "output": "Urine screening abnormal described as a laboratory test result indicating a finding outside the parameters of normal urine measurements." + }, + { + "input": "Concept: Short fifth metacarpal insulin resistance syndrome (Multiple malformation syndrome with limb defect as major feature)", + "output": "Hereditary Connective Tissue Disorder described as this syndrome has characteristics of bilateral shortening of the fifth fingers and fifth metacarpals. It has been described in several members of one family. Some members of the family also had spherocytosis and insulin resistance. Transmission is autosomal dominant." + }, + { + "input": "Concept: NPI1B02 (Intellectual Product)", + "output": "something described as neuropsychiatric Inventory (NPI) Does the patient talk to people who are not there?" + }, + { + "input": "Concept: up regulation of chemotaxis to arachidonic acid (positive regulation of chemotaxis)", + "output": "regulation of chemotaxis to arachidonic acid described as any process that activates or increases the frequency, rate or extent of chemotaxis to arachidonic acid." + }, + { + "input": "Concept: Self-Conscious About the Way I Dress (Intellectual Product)", + "output": "something described as a question about whether an individual is or was self-concious about the way they dress." + }, + { + "input": "Concept: Nanodevice (Manufactured Object)", + "output": "Manufactured Object described as a functional macromolecule composed of nanoscale components." + }, + { + "input": "Concept: biuret (urea)", + "output": "urea described as used as feed supplement for sheep and cattle since it is a good non-protein nitrogen source. In strongly alkaline solution biuret gives a violet color with copper sulfate." + }, + { + "input": "Concept: Enzyme Replacement or Supplement Agent (Pharmacologic Substance)", + "output": "something described as synthetic enzyme or mixture of enzymes used to replace or supplement enzymes to treat enzyme deficiency or to promote healthy body functions." + }, + { + "input": "Concept: microtubule anchoring at SPB (cell cycle process)", + "output": "cell cycle process described as any process in which a microtubule is maintained in a specific location in a cell by attachment to a spindle pole body. Microtubules attach to spindle pole bodies at the minus end." + }, + { + "input": "Concept: Ca2+ phosphate urolithiasis (Urolithiasis)", + "output": "Disease or Syndrome described as urolithiasis in which the composition of the stones is predominantly calcium phosphate." + }, + { + "input": "Concept: OSTEOTOME, MANUAL (Device associated with osteotomes)", + "output": "Medical Device described as a manual surgical instrument for general use is a nonpowered, hand-held, or hand-manipulated device, either reusable or disposable, intended to be used in various general surgical procedures. The device includes the applicator, clip applier, biopsy brush, manual dermabrasion brush, scrub brush, cannula, ligature carrier, chisel, clamp, contractor, curette, cutter, dissector, elevator, skin graft expander, file, forceps, gouge, instrument guide, needle guide, hammer, hemostat, amputation hook, ligature passing and knot-tying instrument, knife, blood lancet, mallet, disposable or reusable aspiration and injection needle, disposable or reusable suturing needle, osteotome, pliers, rasp, retainer, retractor, saw, scalpel blade, scalpel handle, one-piece scalpel, snare, spatula, stapler, disposable or reusable stripper, stylet, suturing apparatus for the stomach and intestine, measuring tape, and calipers. A surgical instrument that has specialized uses in a specific medical specialty is classified in separate regulations in Parts 868 through 892." + }, + { + "input": "Concept: meningeal carcinomatosis (Non-infective meningitis)", + "output": "Malignant neoplasm of meninges described as a serious problem that may occur in cancer in which cancer cells spread from the original (primary) tumor to the meninges (thin layers of tissue that cover and protect the brain and spinal cord). It can happen in many types of cancer, but is the most common in melanoma, breast, lung, and gastrointestinal cancer. The cancer may cause the meninges to be inflamed." + }, + { + "input": "Concept: Abnormality of greater sciatic notch (Abnormality of pelvic girdle bone morphology)", + "output": "Anatomical Abnormality described as an abnormality of the sacrosciatic notch, i.e., the deep indentation in the posterior border of the hip bone at the point of union of the ilium and ischium." + }, + { + "input": "Concept: GAIA Level 2 Preeclampsia (GAIA Preeclampsia Level of Diagnostic Certainty)", + "output": "something described as GAIA Level 2 Preeclampsia is defined by three criteria: first, the gestational age of the pregnancy must be greater than or equal to 20 weeks; second, a diagnosis of new onset maternal hypertension (systolic blood pressure greater than or equal to 140mmHg and/or diastolic blood pressure greater than or equal to 90mmHg) that is sustained on two measurements for a minimum of one hour; third, a diagnosis of new onset proteinuria that is a level 2 diagnostic certainty (proteinuria diagnosed with greater than or equal to 1+ protein on urine dipstick)." + }, + { + "input": "Concept: Neuropsychiatric Inventory Questionnaire Test Name (Intellectual Product)", + "output": "something described as the Neuropsychiatric Inventory test name." + }, + { + "input": "Concept: OLF (Gene or Genome)", + "output": "Glycosyltransferase Gene described as this gene is involved in serine/threonine mannosylation." + }, + { + "input": "Concept: positive regulation of wound healing (positive regulation of response to wounding)", + "output": "positive regulation of response to wounding described as any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury." + }, + { + "input": "Concept: cortex motor (Precentral gyrus)", + "output": "Region of cerebral cortex described as area of the frontal lobe concerned with primary motor control; it lies anterior to the central sulcus." + }, + { + "input": "Concept: Nursing & Custodial Care Facilities; Intermediate Care Facility, Mentally Retarded (Place of Service Codes for Professional Claims)", + "output": "Manufactured Object described as (1) A public institution for care of the mentally retarded or people with related conditions. (2) An institution giving active treatment to mentally retarded or developmentally disabled persons or persons with related conditions. The primary purpose of the institution is to provide health or rehabilitative services to such individuals." + }, + { + "input": "Concept: H2BC20P wt Allele (H2BC20P Gene)", + "output": "Gene or Genome described as human H2BC20P wild-type allele is located in the vicinity of 1q21.2 and is approximately 6 kb in length. This allele, which encodes putative histone H2B type 2-C protein, may be involved in the structure of histone complexes." + }, + { + "input": "Concept: mismatch repair complex binding (Molecular Function)", + "output": "Molecular Function described as interacting selectively and non-covalently with a mismatch repair complex." + }, + { + "input": "Concept: FAM38B2 (Gene or Genome)", + "output": "PIEZO2 gene described as human PIEZO2 wild-type allele is located in the vicinity of 18p11.21 and is approximately 479 kb in length. This allele, which encodes piezo-type mechanosensitive ion channel component 2 protein, plays a role in the conduction of mechanical impulses." + }, + { + "input": "Concept: Circulation, Placental (Organ or Tissue Function)", + "output": "Blood Circulation described as the circulation of BLOOD, of both the mother and the FETUS, through the PLACENTA." + }, + { + "input": "Concept: WATER,DISTILLED (Pharmacologic Substance)", + "output": "Inorganic Chemical described as an ultra-pure form of water with potential antineoplastic activity. Derived by boiling impure water and condensing the resultant steam in a sterile container, distilled water has been shown to kill bladder cancer cells in vitro through osmotic lysis" + }, + { + "input": "Concept: Stage IIB Distal Bile Duct Cancer AJCC v7 (Distal Bile Duct Cancer by AJCC v7 Stage)", + "output": "Distal Bile Duct Cancer by AJCC v7 Stage described as stage IIB includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T1: Tumor confined to the bile duct histologically. T2: Tumor invades beyond the wall of the bile duct. T3: Tumor invades the gallbladder, pancreas, duodenum, or other adjacent organs without involvement of the celiac axis or the superior mesenteric artery. N1: Regional lymph node metastasis. M0: No distant metastasis." + }, + { + "input": "Concept: Bendamustina (Pharmacologic Substance)", + "output": "Nitrogen mustard analogues described as the active ingredient in a drug that is used to treat chronic lymphocytic leukemia (CLL), to treat slow-growing B-cell non-Hodgkin lymphoma (NHL) that has gotten worse within 6 months of treatment with other anticancer drugs, and is being studied in the treatment of other types of cancer. Bendamustine may damage the DNA in cancer cells and cause them to die. It is a type of alkylating agent and a type of antimetabolite." + }, + { + "input": "Concept: 2-deoxystreptamine synthesis (2-deoxystreptamine metabolic process)", + "output": "antibiotic biosynthetic process described as the chemical reactions and pathways resulting in the formation of 2-deoxystreptamine." + }, + { + "input": "Concept: Atypical Bovine spongiform encephalopathy (BSE) - H or L type (Disease or Syndrome)", + "output": "Disease or Syndrome described as h or L type BSE" + }, + { + "input": "Concept: Air Cleaners, Germicical, Ultraviolet Light (Medical Device)", + "output": "something described as germicidal air cleaners designed to kill most bacteria (e.g., Mycobacterium tuberculosis) and many virus types using ultraviolet (UV) radiation. These devices are typically enclosed metal (usually stainless steel) air cleaners with UV (radiation at 254 nm is typical) lamps, particulate filters, fans, and switches. UV germicidal air cleaners are intended for continuous use in healthcare facilities, including waiting rooms and doctors' offices, especially where ceiling height or other conditions do not allow the installation of UV lamps higher than 7 feet; the devices are less effective against fungus and bacteria spores." + }, + { + "input": "Concept: miRNA, Primary (Biologically Active Substance)", + "output": "RNA, Untranslated described as the RNA transcript of the miRNA genes prior to processing to pre-miRNA." + }, + { + "input": "Concept: (N,N-bis(2-chloroethyl))-2-aminoethyl-3-((acridin-9-yl)amino)propionate (Pharmacologic Substance)", + "output": "Organic Chemical described as a quinacrine mustard compound with potential antineoplastic activity. Amustaline binds to, intercalates and crosslinks DNA and RNA. This agent is mainly used for ex vivo purposes, specifically for the inactivation of pathogens such as viruses, protozoa and bacteria in red blood cells (RBCs)." + }, + { + "input": "Concept: Core Assembly (Virus Physiological Phenomena)", + "output": "something described as assembly of virus core." + }, + { + "input": "Concept: trans-synaptic signaling by neuropeptide (synaptic signaling via neuropeptide)", + "output": "synaptic signaling via neuropeptide described as cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft." + }, + { + "input": "Concept: negative regulation of maintenance of meiotic sister chromatid cohesion (Negative Regulation of Meiosis)", + "output": "regulation of maintenance of meiotic sister chromatid cohesion described as any process that decreases the extent to which the association between sister chromatids of a replicated chromosome is maintained during a meiotic cell cycle." + }, + { + "input": "Concept: Anatomical space structure (Anatomic structures)", + "output": "Body Space or Junction described as non-material physical anatomical entity of three dimensions, which is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more body substances or anatomical structures. Examples: celom, thoracic cavity, lesser sac of peritoneum, cavity of right atrium, lumen of aorta, mediastinum, anterior compartment of forearm, intervertebral foramen." + }, + { + "input": "Concept: unmarried (marital history)", + "output": "something described as the person is not presently married. The marital history is not known or stated" + }, + { + "input": "Concept: Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-alpha-D-galacto-octopyranoside (C [Preparations])", + "output": "Antibiotics, Aminoglycoside described as an antibacterial drug" + }, + { + "input": "Concept: up regulation of synaptic vesicle transport (positive regulation of transport)", + "output": "positive regulation of transport described as any process that activates or increases the frequency, rate or extent of synaptic vesicle transport." + }, + { + "input": "Concept: Kingdom Prokaryote (Organism)", + "output": "Other Organism Groupings described as organisms without a cell nucleus or any other membrane-bound organelles. Most prokaryotes are bacteria but the group includes both the Bacteria and the Archaea. Eukaryota, Bacteria, and Archaea are now considered the top nodes of a three-domain taxonomy system." + }, + { + "input": "Concept: Grade 4 Duodenal Hemorrhage, CTCAE (Duodenal Hemorrhage, CTCAE 5)", + "output": "Duodenal Hemorrhage, CTCAE 5 described as life-threatening consequences; urgent intervention indicated" + }, + { + "input": "Concept: Familial cutaneous malignant melanoma (Familial neoplastic disease)", + "output": "Familial neoplastic disease described as a rare inherited form of cutaneous melanoma with characteristics of development of histologically confirmed melanoma in two first degrees relatives or more relatives in an affected family. It is thought to account for about 10% of all cases of cutaneous melanoma. Tends to occur earlier than non-familial melanoma. The risk of familial melanoma is closely related to a wide range of genetic alterations in susceptibility genes but also appears to be influenced by phenotypic risk factors, such as pigmentation, freckling and sun reactions. Complex interactions between genetic and environmental factors are therefore thought to underlie the disease. The most common high-penetrance susceptibility gene implicated is CDKN2A, accounting for predisposition in approximately 20% of cases. In some affected families, susceptibility is consistent with autosomal dominant inheritance but in most cases, a polygenic mode of inheritance appears likely." + }, + { + "input": "Concept: Vaccinium myrtillus/Macleaya cordata/Echinacea angustifolia Extract Granules (Organic Chemical)", + "output": "Pharmacologic Substance described as a proprietary suspension formulation prepared from granules of standardized extracts from the fruits of Vaccinium myrtillus, the aerial parts of Macleaya cordata and the roots of Echinacea angustifolia, with potential anti-mucositis, anti-inflammatory, and analgesic activities. The main active ingredients of this formulation include anthocyanosides and procyanidins, benzophenanthridinic alkaloids, and alkylamides from V. myrtillus, M. cordata and E. angustifolia extracts, respectively. Upon administration in the mucosal cavity, the anthocyanosides scavenge free radicals, form a protective barrier on the mucosa, and protect the integrity of the capillary vessels; the benzophenanthridine alkaloids prevent the production of pro-inflammatory cytokines by inhibiting NF-kB and may halt the growth of microorganisms; the alkylamides inhibit cyclooxygenase and 5-lipoxygenase thereby blocking productions of prostaglandin and leukotriene. Furthermore, alkylamides modulate the expression of tumor necrosis factor alpha and other cytokines involved in inflammation processes through cannabinoid type 2 receptors and as cannabinomimetics they may also exert analgesic activity." + }, + { + "input": "Concept: (4S)-4-hydroxy-2-oxoglutarate aldolase activity (Molecular Function)", + "output": "oxo-acid-lyase activity described as catalysis of the reaction:(4S)-4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate." + }, + { + "input": "Concept: Panic attack (Abnormal fear/anxiety-related behavior)", + "output": "Panic described as an episode of intense fear accompanied by symptoms such as heart palpitations, sweating and chills or hot flushes, a sensation of dyspnea, chest pain, abdominal distress, depersonalization, fear of going crazy, and fear of dying." + }, + { + "input": "Concept: Left optic tract (Structure of left visual pathway)", + "output": "Structure of left visual pathway described as optic tract which is continuous with the optic chiasm and the left lateral geniculate nucleus." + }, + { + "input": "Concept: Distal spinal muscular atrophy type 3 (Disease or Syndrome)", + "output": "something described as a rare neuromuscular disease with characteristics of progressive muscular weakness and atrophy predominantly affecting distal parts of limbs, later involvement of proximal and trunk muscles with marked hyperlordosis and late diaphragmatic dysfunction." + }, + { + "input": "Concept: sbsqntxofc150min homeo ntak (Remote location existing client without ICD diagnosis)", + "output": "something described as using homeopathic assessment methods in a comprehensive, prolonged, subsequent, 150-minute, out-of-office meeting to assess the health status of an existing homeopathy client to reevaluate and/or develop a homeopathic treatment plan." + }, + { + "input": "Concept: Joining Region, Ig (Immunoglobulins)", + "output": "something described as the portion of the light and heavy chains of immunoglobulin molecules where the variable and constant regions meet." + }, + { + "input": "Concept: vitamin D2 (Calcidiol & Calciferol)", + "output": "Calcidiol & Calciferol described as vitamin D2, a fat-soluble vitamin important for many biochemical processes including the absorption and metabolism of calcium and phosphorus. In vivo, ergocalciferol is formed after sun (ultraviolet) irradiation of plant-derived ergosterol, another form of vitamin D. Ergocalciferol is the form of vitamin D usually found in vitamin supplements. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29029\" active clinical trials using this agent." + }, + { + "input": "Concept: Intravenous Ferric Hydroxide Saccharate (Clinical Drug)", + "output": "Clinical Drug described as a sterile aqueous complex of polynuclear iron (III)-hydroxide in sucrose for intravenous use. Following intravenous administration, iron sucrose is dissociated by the reticuloendothelial system into iron and sucrose; the sucrose component is eliminated mainly by urinary excretion. Iron sucrose can be administered with or without erythropoietin to raise hemoglobin levels and may be used in cases of oral iron therapy intolerance or ineffectiveness. Hypersensitivity reactions are less common with iron sucrose compared to other parenteral iron products, such as iron dextran." + }, + { + "input": "Concept: PlannedCriterionGroupCompositionRelationship.pauseQuantity (Temporal Concept)", + "output": "Temporal Concept described as a quantity of time that should elapse between when an activity is ready for execution and the actual beginning of the execution." + }, + { + "input": "Concept: Management, Data (health science research)", + "output": "Research Activity described as processes for data acquisition, validation, storage, protection, and processing." + }, + { + "input": "Concept: Pharmaceutical Quality/CMC Drug Substance Product Indicator Terminology (Intellectual Product)", + "output": "Intellectual Product described as a category of terminology used to qualify the information pertaining to drug substances product indicators in the framework of the Pharmaceutical Quality/Chemistry, Manufacturing and Controls documents." + }, + { + "input": "Concept: Fractionated Stereotactic Radiotherapy (Radiosurgery, Stereotactic)", + "output": "something described as stereotactic radiation therapy that uses multiple, smaller doses of radiation therapy spread over several treatment session." + }, + { + "input": "Concept: Report of Prior Investigations (Report)", + "output": "Intellectual Product described as a report of all prior clinical, animal, and laboratory testing of a medical device." + }, + { + "input": "Concept: Ifosfamide-Etoposide Rhabdomyosarcoma Regimen (Therapeutic or Preventive Procedure)", + "output": "Therapeutic or Preventive Procedure described as a chemotherapy regimen consisting of etoposide and ifosfamide that may be used in the treatment of rhabdomyosarcoma." + }, + { + "input": "Concept: Lung Cancer cM0 TNM Finding v7 (Finding)", + "output": "Finding described as lung cancer without evidence of distant metastasis." + }, + { + "input": "Concept: rndx post-trauma response (Coping Behavior)", + "output": "Negative Diagnosis And Outcome described as sustained maladaptive response to a traumatic, overwhelming event." + }, + { + "input": "Concept: Epiphyseal punctate calcifications (Abnormal epiphyseal ossification)", + "output": "Limb structure described as the presence of abnormal punctate (speckled, dot-like) calcifications in one or more epiphyses." + }, + { + "input": "Concept: 5 Ethyl 3 Methyl 5 Phenylhydantoin (Anticonvulsants)", + "output": "Pharmacologic Substance described as a heterocyclic organic compound with anticonvulsant property. Although the mechanism of action is not well established, mephenytoin potentially promotes sodium efflux from neurons in motor cortex, and stabilizes the threshold against hyperexcitability caused by excessive stimulation. Thus this agent reduces the membrane sodium gradient and prevents cortical seizure signal spreading. It may cause blood dyscrasias, therefore, this agent was only used after other less toxic anticonvulsants had failed." + }, + { + "input": "Concept: Grade 3 Neonatal Sinus Tachycardia, Adverse Event (Finding)", + "output": "something described as persistent tachycardia; resulting in non-life threatening hemodynamic compromise; requiring major care changes (e.g. new medication or intervention)." + }, + { + "input": "Concept: Free Kappa Light Chain Measurement (Laboratory Procedure)", + "output": "Immunologic Tests described as a measurement of the free kappa light chain in a biological specimen." + }, + { + "input": "Concept: Anogenital Distance Decreased (Disorder of female pelvic region and peritoneum)", + "output": "Abnormal Finding described as an indication that the anogenital distance is less than the norm." + }, + { + "input": "Concept: BMP5 wt Allele (Gene or Genome)", + "output": "Gene or Genome described as human BMP5 wild-type allele is located in the vicinity of 6p12.1 and is approximately 120 kb in length. This allele, which encodes bone morphogenetic protein 5, plays a role in serine/threonine kinase signal transduction and induces cartilage and bone formation." + }, + { + "input": "Concept: OROQEN (Ethnic group)", + "output": "something described as a Chinese person from the Oroqen ethnic group." + }, + { + "input": "Concept: Undefined physical performance test narrative required (Therapeutic or Preventive Procedure)", + "output": "something described as any elsewhere undefined physical performance test, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com." + }, + { + "input": "Concept: SBDS (Translation Process Protein)", + "output": "Translation Process Protein described as ribosome maturation protein SBDS (250 aa, ~29 kDa) is encoded by the human SBDS gene. This protein plays a role in ribosome assembly." + }, + { + "input": "Concept: 11p12 (Cell Component)", + "output": "Cell Component described as a chromosome band present on 11p" + }, + { + "input": "Concept: Single-Cell Analysis (Cytological Techniques)", + "output": "electrical measurement described as assaying the products of or monitoring various biochemical processes and reactions in an individual cell." + }, + { + "input": "Concept: NPB-No Palliative Benefit (Finding)", + "output": "something described as an indication that the treatment for a patient is not relieving symptoms or providing comfort." + }, + { + "input": "Concept: Structure of salpingopharyngeal fold (Body Location or Region)", + "output": "Anatomical feature described as subdivision of viscerocranial mucosa behind the opening of the pharyngotympanic tube. Examples: There are only two instances, right and left salpingopharyngeal folds." + }, + { + "input": "Concept: microRNA 370 (Gene or Genome)", + "output": "something described as this gene is involved in the regulation of gene expression and plays a potential tumor suppressor role in cholangiocarcinoma." + }, + { + "input": "Concept: C-SSRS Baseline/Screening Version - Actual Suicide Attempt (Intellectual Product)", + "output": "something described as columbia-Suicide Severity Rating Scale Baseline/Screening Version - Have you made a suicide attempt? Have you done anything to harm yourself? Have you done anything dangerous where you could have died? (Past _ Years)." + }, + { + "input": "Concept: Fetal position, function (Intrapartum fetal status)", + "output": "Fetal finding described as the position of the fetus in the uterus." + }, + { + "input": "Concept: Ferret brand of ferrous fumarate (Inorganic Chemical)", + "output": "Inorganic Chemical described as brand of ferrous fumarate" + }, + { + "input": "Concept: 9-83 DISSOCIATIVE DISORDERS (Hysteria)", + "output": "Dissociative, conversion and factitious disorders described as mental disorders characterized by disruptions and/or alterations in the normally integrated functions of consciousness, memory, or identity. Compare DISSOCIATION." + }, + { + "input": "Concept: Incision-induced Bleeding Method (Research Techniques)", + "output": "Laboratory Procedure described as any of multiple methods used to assess bleeding time, in which a controlled incision is made in the dermis and clotting time is measured." + }, + { + "input": "Concept: Membrane Antigen MN (Amino Acid, Peptide, or Protein)", + "output": "Lyase described as carbonic anhydrase 9 (459 aa, ~50 kDa) is encoded by the human CA9 gene. This protein is involved in intracellular pH balance and may be involved in cell proliferation and transformation." + }, + { + "input": "Concept: DPF2 wt Allele (DPF2 gene)", + "output": "DPF2 gene described as human DPF2 wild-type allele is located in the vicinity of 11q13.1 and is approximately 19 kb in length. This allele, which encodes zinc finger protein ubi-d4, is involved in histone binding and modification. Mutation of the gene is associated with Coffin-Siris syndrome 7." + }, + { + "input": "Concept: CLAMP, ELECTRICAL (Medical Device)", + "output": "Medical Device described as an endoscopic electrosurgical unit and accessories is a device used to perform electrosurgical procedures through an endoscope. This generic type of device includes the electrosurgical generator, patient plate, electric biopsy forceps, electrode, flexible snare, electrosurgical alarm system, electrosurgical power supply unit, electrical clamp, self-opening rigid snare, flexible suction coagulator electrode, patient return wristlet, contact jelly, adaptor to the cord for transurethral surgical instruments, the electric cord for transurethral surgical instruments, and the transurethral desiccator." + }, + { + "input": "Concept: Luteotropin (Gonad regulating hormone agent)", + "output": "Gonadotropins described as glycoprotein hormone secreted by the anterior pituitary; in mammals it stimulates the production of milk and assists in maintaining the corpus luteum." + }, + { + "input": "Concept: early viral transcription (Viral Transcription)", + "output": "Viral Transcription described as the first phase of viral transcription that occurs after entry of the virus into the host cell, but prior to viral genome replication. It involves the transcription of genes for non-structural proteins, and for lytic viruses, the early gene products are involved in establishing control over the host cell." + }, + { + "input": "Concept: eukaryotic translation initiation factor 3 complex location, eIF3e (Cell Component)", + "output": "eukaryotic translation initiation factor 3 complex location described as an eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3e." + }, + { + "input": "Concept: Yellow Rocket (Plant)", + "output": "Barbarea described as a common weed, conspicuous in fields due to its bright yellow spring flowers." + }, + { + "input": "Concept: Power of muscles of one limb (Muscle power functions)", + "output": "something described as functions related to the force generated by the contraction of the muscles and muscle groups of one arm or leg." + }, + { + "input": "Concept: Reduced brain lactate level by MRS (Abnormal brain lactate level by MRS)", + "output": "Finding described as a decrease in the level of lactate in the brain identified by magnetic resonance spectroscopy (MRS). []" + }, + { + "input": "Concept: Excision;skin (Integumentary system excision)", + "output": "Therapeutic or Preventive Procedure described as a surgical procedure used to remove moles, cysts, skin cancer, and other skin growths using local anesthesia. To treat skin cancer, the doctor uses a scalpel to remove the entire tumor and some of the healthy tissue around it." + }, + { + "input": "Concept: Sulci cerebri (Cerebrum)", + "output": "Brain part described as a header term that encompasses the various cerebral sulcus terms." + }, + { + "input": "Concept: Fructose-1,6-Bisphosphatase 1 wt Allele (Gene or Genome)", + "output": "something described as human FBP1 wild-type allele is located in the vicinity of 9q22.3 and is approximately 37 kb in length. This allele, which encodes fructose-1,6-bisphosphatase 1 protein, is involved in gluconeogenesis. Mutation of the gene is associated with fructose-1,6-bisphosphatase deficiency, which can cause life-threatening episodes of hypoglycemia and metabolic acidosis." + }, + { + "input": "Concept: QS-RAND-36 V1.0 TEST (Intellectual Product)", + "output": "CDISC Questionnaire Terminology described as test names of questionnaire questions associated with the RAND 36-Item Health Survey 1.0 for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM)." + }, + { + "input": "Concept: TSCYC108 (TSCYC Questionnaire Question)", + "output": "Intellectual Product described as trauma Symptom Checklist for Young Children (TSCYC) Please indicate how often he or she has done, felt, or experienced each of the following things in the last month: Not wanting to go somewhere that reminded him or her of a bad thing from the past." + }, + { + "input": "Concept: oncofetal antigen-immature laminin receptor protein-loaded autologous dendritic cell vaccine (Dendritic Cell Vaccine)", + "output": "Dendritic Cell Vaccine described as a cancer vaccine consisting of autologous, mature monocyte-derived dendritic cells (DCs) transfected with oncofetal antigen immature laminin receptor protein (OFA-iLRP) RNA, with potential antineoplastic activity. Upon administration, DCs in the OFA-iLRP RNA-transfected autologous dendritic cell vaccine express, process, and present OFA-iLRP to the host immune system, which may mount a potent cytotoxic T-cell (CTL) response against OFA-iLRP-expressing tumor cells. As a highly conserved protein, OFA-iLRP is preferentially expressed in fetal tissues and in many types of cancer, including hematopoietic malignancies, but is not detectable in normal differentiated adult cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C78830\" active clinical trials using this agent." + }, + { + "input": "Concept: foretinib (Antineoplastic Enzyme Inhibitor)", + "output": "Organic Chemical described as an orally bioavailable small molecule with potential antineoplastic activity. MET/VEGFR2 inhibitor GSK1363089 binds to and selectively inhibits hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of tumor angiogenesis, tumor cell proliferation and metastasis. The proto-oncogene c-MET has been found to be over-expressed in a variety of cancers. VEGFR2 is found on endothelial and hematopoietic cells and mediates the development of the vasculature and hematopoietic cells through VEGF signaling. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C80058\" active clinical trials using this agent." + }, + { + "input": "Concept: 1,2-dihydroxy-1,2,5,6,7,8-hexyhadronaphthalene dehydrogenase activity (oxidoreductase activity, acting on the CH-CH group of donors)", + "output": "something described as catalysis of the reaction: cis-1,2-dihydroxy-1,2,5,6,7,8-hexahydronaphthalene + NAD+ = 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene + NADH + H+." + }, + { + "input": "Concept: Absorbance Unit per Milliliter (Quantitative Concept)", + "output": "something described as a unit of optical density expressed as the absorbance of light transmitted through the medium on the logarithmic scale per unit of volume equal to one milliliter." + }, + { + "input": "Concept: Lateral-Occipital Sulcus (Sulcus of brain)", + "output": "something described as a horizontal groove on the lateral aspect of the occipital lobe of human cerebral cortex. It separates the middle occipital gyrus into superior and inferior parts. In some cases it intersects the lunate sulcus of the human caudally ( Duvernoy-1992 ). Some authors regard the lunate sulcus to be part of the the lateral occipital sulcus ( Van Essen Lab-2002 ).\\r\\nEquivalent structures are not found in the macaque or in the smooth cerebral cortex of the rat and mouse ( NeuroNames )." + }, + { + "input": "Concept: AMUSTALINE (Antineoplastic Agents, Alkylating)", + "output": "Organic Chemical described as a quinacrine mustard compound with potential antineoplastic activity. Amustaline binds to, intercalates and crosslinks DNA and RNA. This agent is mainly used for ex vivo purposes, specifically for the inactivation of pathogens such as viruses, protozoa and bacteria in red blood cells (RBCs)." + }, + { + "input": "Concept: down regulation of fibroblast chemotaxis (regulation of fibroblast chemotaxis)", + "output": "negative regulation of chemotaxis described as any process that stops, prevents or reduces the frequency, rate or extent of fibroblast chemotaxis." + }, + { + "input": "Concept: Recurrent Anterior Pituitary Gland Tumor (Anterior Pituitary Gland Neoplasm)", + "output": "Neoplastic Process described as the re-emergence of a pituitary gland neoplasm after a period of remission." + }, + { + "input": "Concept: taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating) activity (Molecular Function)", + "output": "Molecular Function described as catalysis of the reactions: taurochenodeoxycholate + NADPH + H+ + O2 = taurohyocholate + NADP+ + H2O, and lithocholate + NADPH + H+ + O2 = hyodeoxycholate + NADP+ + H2O." + }, + { + "input": "Concept: Traumatic Olfactory Neuropathies (Olfactory Nerve Disorder)", + "output": "Injury of internal organ described as traumatic injuries to the OLFACTORY NERVE. It may result in various olfactory dysfunction including a complete loss of smell." + }, + { + "input": "Concept: norepinephrine-mediated vasodilation (Organ or Tissue Function)", + "output": "something described as a vasodilation process resulting from secretion of norepinephrine into the bloodstream or released by nerve endings." + }, + { + "input": "Concept: all-trans retinal binding (retinal binding)", + "output": "Molecular Function described as interacting selectively and non-covalently with all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A." + }, + { + "input": "Concept: ANTIGEN, CF (INCLUDING CF CONTROL), HERPESVIRUS HOMINIS 1,2 (Indicator, Reagent, or Diagnostic Aid)", + "output": "Indicator, Reagent, or Diagnostic Aid described as herpes simplex virus serological reagents are devices that consist of antigens and antisera used in various serological tests to identify antibodies to herpes simplex virus in serum. Additionally, some of the reagents consist of herpes simplex virus antisera conjugated with a fluorescent dye (immunofluorescent reagents) used to identify herpes simplex virus directly from clinical specimens or tissue culture isolates derived from clinical specimens. The identification aids in the diagnosis of diseases caused by herpes simplex viruses and provides epidemiological information on these diseases. Herpes simplex viral infections range from common and mild lesions of the skin and mucous membranes to a severe form of encephalitis (inflammation of the brain). Neonatal herpes virus infections range from an mild infection to a severe generalized disease with a fatal outcome." + }, + { + "input": "Concept: Stage IVA Esophageal Squamous Cell Cancer (Pathologic Stage IV Esophageal Squamous Cell Carcinoma AJCC v8)", + "output": "Neoplastic Process described as stage IVA includes: (T4a, N2, M0, Any G, Tumor location: Any); (T4b, N0-2, M0, Any G, Tumor location: Any); (Any T, N3, M0, Any G, Tumor location: Any). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis." + }, + { + "input": "Concept: AUMCIFPW (Area Under First Moment Curve)", + "output": "Area Under First Moment Curve described as the area under the moment curve (AUMC) extrapolated to infinity, calculated using the predicted value of the last non-zero concentration, divided by the weight." + }, + { + "input": "Concept: Blepharoclonus (Myoclonus)", + "output": "Seizures and seizure disorders NEC described as marked, involuntary jerking of the eyelids. []" + }, + { + "input": "Concept: Gerontology (Medical Specialities)", + "output": "Medicine described as the branch of medicine concerned with the physiological and pathological aspects of the aged, including the clinical problems of senescence and senility." + }, + { + "input": "Concept: Geriatric Screening Tool (Intellectual Product)", + "output": "Intellectual Product described as a tool for the assessment of geriatric cancer patients. It combines 7 questions from the mini nutritional assessment (MNA) with one question regarding subject age. Items selected from MNA concern nutritional status, weight loss, body mass index, motor skills, psychological status, number of medications, and self-perception of health." + }, + { + "input": "Concept: Grade 3 Nephrotic Syndrome, CTCAE (Finding)", + "output": "Nephrotic Syndrome, CTCAE described as not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care ADL" + }, + { + "input": "Concept: Mild Dementia or Depression (Clinical or Research Assessment Answer)", + "output": "Clinical or Research Assessment Answer described as a response indicating than an individual has or had mild dementia or depression." + }, + { + "input": "Concept: Body Size (Body Weights and Measures)", + "output": "something described as the physical measurements of a body." + }, + { + "input": "Concept: Tumor Necrosis Factor Receptor Superfamily Member 27 (Amino Acid, Peptide, or Protein)", + "output": "Receptor described as tumor necrosis factor receptor superfamily member 27 (297 aa, ~33 kDa) is encoded by the human EDA2R gene. This protein plays a role in the development and maintenance of ectodermally derived tissues." + }, + { + "input": "Concept: Heavy metal screening (Screening procedure)", + "output": "Heavy metals measurement described as analyzing a client/patient's specimen sample to assess his or her levels of heavy metals, including antimony, arsenic, barium, beryllium, bismuth and/or mercury. Service is billed per test." + }, + { + "input": "Concept: phloem nitrate loading (phloem loading)", + "output": "nitrate transport described as the process of loading nitrate into the sieve tube or companion cell of the phloem for long distance transport from source to sink." + }, + { + "input": "Concept: Shaft of rib (bones of rib cage)", + "output": "Bone structure of rib described as the long, curved portion of the rib, which contains the intercostal vein, artery, and nerve in a groove found in the inferior margin." + }, + { + "input": "Concept: B-lymphocyte deletion (apoptotic process involved in development)", + "output": "something described as the apoptotic death of B cells which is part of B cell tolerance induction." + }, + { + "input": "Concept: MID-JUGULAR LYMPH NODE (Body Part, Organ, or Organ Component)", + "output": "Body Part, Organ, or Organ Component described as lymph nodes located around the middle third of the internal jugular vein, extending from the inferior border of the hyoid bone (above) to the inferior border of the cricoid cartilage (below). The anterior (medial) boundary is the lateral border of the sternohyoid muscle, and the posterior (lateral) boundary is the posterior border of the sternocleidomastoid muscle. These nodes are at greatest risk for harboring metastases from cancers arising from the oral cavity, nasopharynx, oropharynx, hypopharynx, and larynx." + }, + { + "input": "Concept: Lamivudine-containing product (Chemical categorised functionally)", + "output": "Reverse Transcriptase Inhibitors described as a drug used to treat infection caused by viruses." + }, + { + "input": "Concept: FAMS0140 (FAMS Questionnaire Question)", + "output": "something described as functional Assessment of Multiple Sclerosis (FAMS) Family/Social Well-Being: I get support from my friends." + }, + { + "input": "Concept: In-Bee-Hive (Functional Concept)", + "output": "Functional Concept described as administration of a veterinary medicinal product by placing it or sprinkling over a bee hive." + }, + { + "input": "Concept: Mathematical models (Model)", + "output": "Intellectual Product described as use of mathematical formulas or equations to analyze or systematize data for description in quantitative terms." + }, + { + "input": "Concept: Auditory Receptor Cell (Somatosensory Receptor)", + "output": "Sensory Receptor Cells described as receptor cell that is sensitive to mechanical stimulation such as touch, pressure, or tension." + }, + { + "input": "Concept: Medial longitudinal fasciculus of medulla (White matter of medulla oblongata)", + "output": "Medulla Oblongata described as the part of the medial longitudinal fasciculus in the medulla ( Martin-1997 )." + }, + { + "input": "Concept: M(6)A(1618) activity (Genetic Function)", + "output": "Genetic Function described as catalysis of the reaction: S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA." + }, + { + "input": "Concept: Afraid to be Far from a Toilet (Clinical or Research Assessment Question)", + "output": "Intellectual Product described as a question about whether an individual is or was afraid to be far from a toilet." + }, + { + "input": "Concept: Grade 2 Anal Fissure, CTCAE (Anal Fissure, CTCAE)", + "output": "Anal Fissure, CTCAE described as symptomatic" + }, + { + "input": "Concept: meningomyelocele (Spina Bifida Cystica)", + "output": "Central Nervous System described as congenital, or rarely acquired, herniation of meningeal and spinal cord tissue through a bony defect in the vertebral column. The majority of these defects occur in the lumbosacral region. Clinical features include PARAPLEGIA, loss of sensation in the lower body, and incontinence. This condition may be associated with the ARNOLD-CHIARI MALFORMATION and HYDROCEPHALUS." + }, + { + "input": "Concept: Flavivirus infection (Flavivirus Infections)", + "output": "Flaviviridae Infections described as infections with viruses of the genus FLAVIVIRUS, family FLAVIVIRIDAE." + }, + { + "input": "Concept: proteasomal ubiquitin-dependent protein catabolic process (ubiquitin-dependent protein catabolic process)", + "output": "something described as the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." + }, + { + "input": "Concept: DFSPs, Myxoid (Dermatofibrosarcoma)", + "output": "Dermatofibrosarcoma Protuberans described as a morphologic variant of dermatofibrosarcoma protuberans characterized by the presence of extensive myxoid stroma formation and a storiform growth pattern." + }, + { + "input": "Concept: PQL15-Hard to Go Places With Equipment (Intellectual Product)", + "output": "Intellectual Product described as pediatric Quality of Life Neuromuscular Module Acute Version 3.0 Parent Report for Child (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Child) In the past 7 days, how much of a problem has this been for your child: It is hard for my child to go places with his or her equipment." + }, + { + "input": "Concept: VTTARRY (Diagnostic Procedure)", + "output": "something described as an electrocardiographic assessment of the abnormally fast cardiac rhythms originating within the ventricles." + }, + { + "input": "Concept: Improvised Nuclear Device (Manufactured Object)", + "output": "Munition described as a crude nuclear device built from the components of a stolen weapon or from scratch using nuclear material (plutonium or highly enriched uranium)." + }, + { + "input": "Concept: Neuregulin 3 wt Allele (NRG3 gene)", + "output": "NRG3 gene described as human NRG3 wild-type allele is located within 10q22-q23 and is approximately 1,110 kb in length. This allele, which encodes pro-neuregulin-3, membrane-bound isoform protein, plays a role in growth and differentiation." + }, + { + "input": "Concept: Drum (Quantitative Concept)", + "output": "Potency Unit described as a dosing unit equal to the amount of active ingredient(s) contained in a drum." + }, + { + "input": "Concept: DENTURE ADHESIVE, KARAYA AND ETHYLENE-OXIDE HOMOPOLYMER (Medical Device)", + "output": "something described as ethylene oxide homopolymer and/or karaya denture adhesive is a device composed of ethylene oxide homopolymer and/or karaya intended to be applied to the base of a denture before the denture is inserted in a patient's mouth to improve denture retention and comfort." + }, + { + "input": "Concept: DGKA (Phosphotransferases)", + "output": "Amino Acid, Peptide, or Protein described as diacylglycerol kinase alpha (735 aa, ~83 kDa) is encoded by the human DGKA gene. This protein is involved in the negative regulation of second messenger signaling through lipid phosphorylation." + }, + { + "input": "Concept: crusting (Acquired Abnormality)", + "output": "effusion described as a covering or layer of solid matter formed by dried bodily exudate or secretion." + }, + { + "input": "Concept: ATPase WRNIP1 (Enzyme)", + "output": "Hydrolase described as ATPase WRNIP1 (665 aa, ~72 kDa) is encoded by the human WRNIP1 gene. This protein is involved in both ATP hydrolysis and DNA replication." + }, + { + "input": "Concept: BRUCELLA ABORTUS (Brucella species)", + "output": "Bacterium described as a species of aerobic, Gram-negative, coccobacilli shaped bacteria assigned to the phylum Proteobacteria. This species is nonmotile, non-spore forming, reduces nitrates, produces hydrogen sulfide, is positive for catalase, oxidase and urease, grows in basic fuchsin but not thionine, and is positive for Tiblisi and Weybridge phage lysis. B abortus is found in cattle where it causes abortions and causes brucellosis in humans." + }, + { + "input": "Concept: Defined Observation Result Derivation Expression (Intellectual Product)", + "output": "Intellectual Product described as a character string containing a formal language expression that specifies how the observation result's attributes are, should be, or have been derived from input parameters associated with activity." + }, + { + "input": "Concept: Arthropod-borne disease NOS (communicable disease by vector)", + "output": "Disease or Syndrome described as bacterial, viral, or parasitic diseases transmitted to humans and animals by infected arthropods, including ticks." + }, + { + "input": "Concept: Scanning Electron Microscopes (Medical Device)", + "output": "Medical Device described as electron microscopes designed to provide a topographical image of the surface of a specimen, useful for understanding its surface structure. Scanning electron microscopes (SEMs) consist of an electron gun and vacuum chamber, an electromagnetic imaging (lens) system, a scanning system, a specimen chamber, secondary and backscatter detectors, a viewing chamber and fluorescent screen, and photographic and vacuum systems. The imaging system provides an electron beam with a fine focal spot that is deflected horizontally and vertically (i.e., scanning system); the energy exchange between the electron beam and the sample yields electromagnetic radiation that is detected to produce an image. Before observation, tissue samples must be fixed (including cryofixation for some dedicated instruments), processed, embedded, sectioned, mounted on a support stub, and usually coated (e.g., using a sputter coater) with a thin film of a heavy metal (e.g., gold). The clinical use of SEMs has yielded information on hematologic disorders and biological surfaces, such as those of the small intestines and serous cavities." + }, + { + "input": "Concept: Systemic monochloroacetic acid poisoning (Poisoning due to chemical substance)", + "output": "something described as a rare life-threatening intoxication with monochloroacetic acid (mainly through the skin, but also by inhalation or ingestion). It is characterised by vomiting, diarrhoea and central nervous system excitability (disorientation, delirium, convulsions) as early signs of systemic poisoning, followed by central nervous system depression, coma and cerebral oedema. Additional signs include heart involvement (severe myocardial depression, shock, arrhythmias, nonspecific myocardial damage), severe metabolic acidosis, hypokalaemia and hypocalcaemia and progressive renal failure leading to anuria. Myoglobinaemia and leukocytosis may occur. Manifestations may be delayed for 1-4 hours." + }, + { + "input": "Concept: CT7/MAGE-A3/WT1 mRNA-Electroporated LCs (therapeutic autologous dendritic cells)", + "output": "therapeutic autologous dendritic cells described as an autologous tumor cell vaccine containing CD34+ hematopoietic progenitor cell (HPC)-derived Langerhans-type dendritic cells (LCs) electroporated with mRNA encoding the full-length cancer-testis antigens, CT7 and melanoma-associated antigen 3 (MAGE-A3), and the self-differentiation tumor antigen, Wilms tumor 1 (WT1) with potential immunomodulating and antineoplastic activity. The autologous CT7/MAGE-A3/WT1 mRNA-electroporated Langerhans-type dendritic cells are prepared by drawing a blood sample containing the CD34+ HPCs from a cancer patient. The CD34+ HPCs are treated with a combination of cytokines which specifically support LC development, and the LC population is enriched and expanded ex vivo. The cultured LCs are allowed to mature for one day and then electroporated separately with CT7, MAGE-A3 or WT1 mRNA before final maturation. Upon intradermal administration into the patient, the mature LCs may activate cell-mediated immunity and induce both cytotoxic CD8+ T cells and CD4+ helper T cells against cancer cells expressing CT7, MAGE-A3 and WT1 tumor antigens. This may result in the immune-mediated inhibition of tumor cell proliferation, leading to tumor cell death. CT7 and MAGE-A3 are tumor-specific proteins overexpressed in a number of cancers but not in healthy tissues other than testis and placenta. WT1 is a transcription factor important in development and cancer pathogenesis, which is overexpressed in a variety of cancers, including multiple myeloma, leukemia, ovarian cancer, malignant mesothelioma, neural tumors and renal carcinoma." + }, + { + "input": "Concept: glutamate signalling pathway (cell surface receptor signaling pathway)", + "output": "cell surface receptor signaling pathway described as a series of molecular signals initiated by the binding of glutamate to a glutamate receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." + }, + { + "input": "Concept: N-benzoyl-L-glutamate synthetase activity (ligase activity, forming carbon-nitrogen bonds)", + "output": "ligase activity, forming carbon-nitrogen bonds described as catalysis of the reaction: benzoate + L-glutamate + ATP <=> H+ + N-benzoyl-L-glutamate + AMP + diphosphoric acid." + }, + { + "input": "Concept: Dipping Route of Administration (Veterinary Route of Administration)", + "output": "Veterinary Route of Administration described as administration of a veterinary medicinal product by immersing the animal into a bath or plunge pool containing the medicinal product." + }, + { + "input": "Concept: Arteriole (Microcirculation)", + "output": "ARTERIES: TYPE AND STRUCTURE described as a small, terminal branch in the arterial system. Arterioles often connect to capillaries." + }, + { + "input": "Concept: CD45RA - Cluster of differentiation antigen 45 RA (Cluster of differentiation antigen 1-55)", + "output": "Immunologic Factor described as CD45RA is encoded by the human PTPRC gene. This protein plays a role in both lymphocyte function and protein dephosphorylation. It is an isoform of receptor-type tyrosine-protein phosphatase C that is missing the amino acids encoded by exons 5 and 6 of the PTPRC gene." + }, + { + "input": "Concept: BROWN-VIALETTO-VAN LAERE SYNDROME 1 (Disease or Syndrome)", + "output": "Syndrome described as an autosomal recessive neurologic condition caused by mutation(s) in the SLC52A3 gene, encoding solute carrier family 52, riboflavin transporter, member 3. It is characterized by sensorineural hearing loss and varying cranial nerve palsies, usually affecting the motor components of the seventh and ninth to twelfth cranial nerves. Spinal motor nerves are often affected. Mutations in SLC52A3 may result in Faxio-Lone disease, which is a similar condition, but sensorineural deafness is not present." + }, + { + "input": "Concept: Malignant haemangiopericytoma (Blood Vessel Tumors)", + "output": "Primary malignant neoplasm described as an uncommon malignant neoplasm arising from pericytes. Distinction between benign and malignant hemangiopericytoma may be difficult or even impossible on morphologic grounds alone." + }, + { + "input": "Concept: fascin 1 protein, human (Biologically Active Substance)", + "output": "Cytoskeletal Proteins described as fascin (493 aa, ~55 kDa) is encoded by the human FSCN1 gene. This protein is involved in the formation of actin filaments." + }, + { + "input": "Concept: zinc finger protein 42 (Gene or Genome)", + "output": "something described as this gene may be involved in transcriptional regulation." + }, + { + "input": "Concept: Phenolphthaleinum (Cathartics)", + "output": "Organic Chemical described as an organic compound used as a laboratory reagent and pH indicator. Phenolphthalein exerts laxative effects by stimulating the intestinal mucosa and constricting smooth muscles. However, phenolphthalein is no longer used as a laxative due to the suspected carcinogenicity of this compound." + }, + { + "input": "Concept: v-raf Murine Sarcoma Viral Oncogene Homolog B1 Gene (BRAF gene)", + "output": "BRAF gene described as human BRAF wild-type allele is located within 7q34 and is approximately 190 kb in length. This allele, which encodes B-Raf proto-oncogene serine/threonine-protein kinase protein, plays a role in the transduction of mitogenic signals from the cell membrane to the nucleus. A specific activating somatic mutation in the BRAF gene is associated with several types of cancer such as colorectal and thyroid carcinomas and malignant melanoma." + }, + { + "input": "Concept: IVD Test Reagent/Kits, Immunoassay, Thyroid Hormone, Binding Ratio (Medical Device)", + "output": "Medical Device described as immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (typically serum) to determine the unsaturated thyroid hormone (either triiodothyronine (T3) or thyroxin (T4)), binding capacity (i.e., the number of unoccupied thyroid hormone binding sites on serum proteins). Usually these values (i.e. the \"uptake\" results) are determined in relation to values in serum from patients with normal thyroid hormones (i.e., euthyroid patients). The determinations of the relative free fraction of T3 or T4 are known as the thyroid hormone binding ratio (THBR)." + }, + { + "input": "Concept: completionRequiredBeforeStartingIndicator (Indicator)", + "output": "Indicator described as specifies whether an event or activity must be completed prior to starting another activity." + }, + { + "input": "Concept: serpin peptidase inhibitor, clade F, member 2, human (Serine Proteinase Inhibitors)", + "output": "Biologically Active Substance described as alpha-2-antiplasmin (491 aa, ~55 kDa) is encoded by the human SERPINF2 gene. This protein plays a role in the regulation of plasmin-mediated processes during blood coagulation." + }, + { + "input": "Concept: mineralization of bone (Organ or Tissue Function)", + "output": "Organ or Tissue Function described as the deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue." + }, + { + "input": "Concept: positive regulation of toll-like receptor signalling pathway (Molecular Function)", + "output": "regulation of toll-like receptor signaling pathway described as any process that activates or increases the frequency, rate, or extent of toll-like receptor signaling pathway." + }, + { + "input": "Concept: Endothelium Derived Vasoconstrictor Factor Receptors (Peptide Receptor)", + "output": "Receptor described as cell surface proteins that bind ENDOTHELINS with high affinity and trigger intracellular changes which influence the behavior of cells." + }, + { + "input": "Concept: craniosynostosis-arthrogryposis-cleft palate syndrome (Disease or Syndrome)", + "output": "something described as a syndrome of craniosynostosis. microcephaly, arthrogryposis, and cleft palate and varied craniofacial, respiratory, neurological, and limb abnormalities." + }, + { + "input": "Concept: Orbital Sarcoma Pathologic TNM Finding v8 (Orbital Sarcoma TNM Finding v8)", + "output": "Orbital Sarcoma TNM Finding v8 described as a pathologic finding about one or more characteristics of orbital sarcoma, following the rules of the TNM AJCC v8 classification system." + }, + { + "input": "Concept: IPODATE (Drug allergens)", + "output": "I [Preparations] described as ionic monomeric contrast media. Usually the sodium or calcium salts are used for examination of the gall bladder and biliary tract." + }, + { + "input": "Concept: Monooxygenase (Enzyme)", + "output": "Enzyme described as widely distributed enzymes that carry out oxidation-reduction reactions in which one atom of the oxygen molecule is incorporated into the organic substrate; the other oxygen atom is reduced and combined with hydrogen ions to form water. They are also known as monooxygenases or hydroxylases. These reactions require two substrates as reductants for each of the two oxygen atoms. There are different classes of monooxygenases depending on the type of hydrogen-providing cosubstrate (COENZYMES) required in the mixed-function oxidation." + }, + { + "input": "Concept: activation of 17-methylnonadec-1-ene biosynthetic process (Molecular Function)", + "output": "positive regulation of cellular biosynthetic process described as any process that activates or increases the frequency, rate or extent of 17-methylnonadec-1-ene biosynthetic process." + }, + { + "input": "Concept: dihydroneopterin triphosphate pyrophosphohydrolase activity (pyrophosphatase activity)", + "output": "Molecular Function described as catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate." + }, + { + "input": "Concept: SIGAMP (Spatial Concept)", + "output": "something described as a measurement of the height of the signal such as a magnetic pulse." + }, + { + "input": "Concept: Inpatient hospital (Manufactured Object)", + "output": "something described as includes all inpatient stays, including: same-day hospital discharges, hospital transfers, and acute hospital care where the discharge is after the admission date." + }, + { + "input": "Concept: suppression by virus of host protein kinase activity (suppression by virus of host catalytic activity)", + "output": "suppression by virus of host catalytic activity described as any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protein kinase activity." + }, + { + "input": "Concept: monoubiquitinated protein deubiquitinylation (Deubiquitination)", + "output": "Molecular Function described as the removal of the ubiquitin group from a monoubiquitinated protein." + }, + { + "input": "Concept: negative regulation of tRNA metabolic process (regulation of tRNA metabolic process)", + "output": "negative regulation of RNA metabolic process described as any process that stops, prevents or reduces the frequency, rate or extent of tRNA metabolic process." + }, + { + "input": "Concept: Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (Parenchymal lung disorders NEC)", + "output": "Parenchymal lung disorders NEC described as a very rare condition characterized by generalized proliferation of pulmonary neuroendocrine cells. It manifests as progressive cough and dyspnea. It is considered a precursor for pulmonary carcinoid tumor." + }, + { + "input": "Concept: Granular Coarse Casts (Urine Sediment Analysis Measurement)", + "output": "something described as a measurement of the coarse granular casts present in a biological specimen." + }, + { + "input": "Concept: Potyviruses (Virus)", + "output": "Virus described as a large genus of plant viruses of the family POTYVIRIDAE which infect mainly plants of the Solanaceae. Transmission is primarily by aphids in a non-persistent manner. The type species is potato virus Y." + }, + { + "input": "Concept: asthenozoospermia (Male infertility)", + "output": "Male infertility described as a condition in which the percentage of motile sperm is abnormally low." + }, + { + "input": "Concept: Gallbladder Cancer by AJCC v7 Stage (Neoplastic Process)", + "output": "Gallbladder Carcinoma described as a term that refers to the staging of gallbladder cancer according to the American Joint Committee on Cancer, 7th edition." + }, + { + "input": "Concept: Sense Codons (Nucleotide Sequence)", + "output": "Nucleotide Sequence described as any of the codons of an organism's GENETIC CODE that specify an amino acid." + }, + { + "input": "Concept: Small Inducible Cytokine B6 (Immunologic Factor)", + "output": "CXC Chemokines described as a CXC chemokine that has stimulatory and chemotactic activities towards NEUTROPHILS. It has specificity for CXCR1 RECEPTORS and CXCR2 RECEPTORS." + }, + { + "input": "Concept: Involuntary movement functions, unspecified (Organism Function)", + "output": "Organism Function described as functions of unintentional, non- or semi-purposive involuntary contractions of a muscle or group of muscles." + }, + { + "input": "Concept: MAP Kinase Signaling System (Signal Transduction)", + "output": "Molecular Function described as an intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade." + }, + { + "input": "Concept: Lung Cancer pM1a TNM Finding v8 (Lung Cancer pM1 TNM Finding v8)", + "output": "Lung Cancer pM1 TNM Finding v8 described as lung cancer with separate tumor nodule(s) in a contralateral lobe; tumor with pleural or pericardial nodules or malignant pleural or pericardial effusion. Most pleural (pericardial) effusions with lung cancer are a result of the tumor. In a few patients, however, multiple microscopic examinations of pleural (pericardial) fluid are negative for tumor, and the fluid is nonbloody and not an exudate. If these elements and clinical judgment dictate that the effusion is not related to the tumor, the effusion should be excluded as a staging descriptor." + }, + { + "input": "Concept: Nursing documentation (Contacting nurse)", + "output": "nursing documentation & reports described as actions performed to document condition by nurse" + }, + { + "input": "Concept: phosphatidylserine synthetase activity (CDP-alcohol phosphatidyltransferase activity)", + "output": "Molecular Function described as catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine." + }, + { + "input": "Concept: SFMP204 (Intellectual Product)", + "output": "something described as short-Form McGill Pain Questionnaire-2 - Sharp pain." + }, + { + "input": "Concept: RALES (Respiratory auscultation finding)", + "output": "Fluid overload status described as abnormal breath sounds (crackles) heard on auscultation, indicating inflammation, fluid, or infection of the lung." + }, + { + "input": "Concept: APQS (Associated Persons Domain)", + "output": "Intellectual Product described as a domain utilized for the submission of questionnaires records related to persons associated with the study subject." + }, + { + "input": "Concept: C4 VERTEBRA (Bone structure of C1-C4)", + "output": "Bone structure of C1-C4 described as the fourth of the seven cervical vertebrae." + }, + { + "input": "Concept: activation of MAPK activity (positive regulation of MAP kinase activity)", + "output": "activation of protein kinase activity described as the initiation of the activity of the inactive enzyme MAP kinase (MAPK)." + }, + { + "input": "Concept: 5-chloro-2,4-dihydroxypyridine (Pyridine and pyridine derivative)", + "output": "Chemical categorised functionally described as a pyridine derivative with antitumor activity. Gimeracil enhances the antitumor activity of fluoropyrimidines by competitively and reversibly inhibiting the enzyme dihydropyrimidine dehydrogenase causing decreased degradation of the fluoropyrimidines. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2416\" active clinical trials using this agent." + }, + { + "input": "Concept: BHUTANESE (Population Group)", + "output": "Mongoloid population described as a person having origins in any of the original peoples of Bhutan." + }, + { + "input": "Concept: Scissors, Surgical, Dura Mater (Medical Device)", + "output": "Neurological device described as surgical scissors designed to cut the outermost of the three membranes (meninges) covering the brain and the spinal cord (i.e., the dura mater). These scissors are typically handheld, manual instruments with two metallic (e.g., stainless steel) angled or slightly curved blades with sharp or blunt (e.g., pointed) tips and very long shanks that slide past each other (i.e., shearing action). The blades are usually attached to handles with the proximal end conformed as a ring to facilitate holding and operating with the fingers; both parts are joined by a swivel pin in the center. Dura mater surgery scissors are used in neurosurgical procedures involving the brain and/or the spinal cord." + }, + { + "input": "Concept: Cardiac muscle tissue of interatrial septum (Cardiac muscle tissue of cardiac septum)", + "output": "Tissue described as cardiac muscle tissue which consists of the interatrial fasciculus and the fibrocollagenous sheath that separates the right from the left cardiac atrium." + } + ] +} \ No newline at end of file